id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255795-su7f5ges	Yelin, Idan	Evaluation of COVID-19 RT-qPCR test in multi-sample pools	2020-03-27		.txt	text/plain	2262	113	55	Here, testing a pooling approach for the standard RT-qPCR test, we find that a single positive sample can be detected even in pools of up to 32 samples, with an estimated false negative rate of 10%. We hope that such implementation of a pool test for COVID-19 would allow expanding current screening capacities thereby enabling the expansion of detection in the community, as well as in close integral groups, such as hospital departments, army units, or factory shifts. Here, we test the ability of the standard RT-qPCR test for detecting a single positive sample within a pool of negative samples. Pooling clinical RNA samples, we tested previously confirmed positive samples alone and combined with an increasing number of previously confirmed negative samples and found that positive samples can still be well observed in pools of up to 32 samples, and possibly even 64 with additional PCR cycles. We found that a single clinical sample with SARS-CoV-2 RNA can be consistently detected in a pool of up to 32 samples.	./cache/cord-255795-su7f5ges.txt	./txt/cord-255795-su7f5ges.txt