id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-263468-996kl9jz	Cattaneo, Roberto	Biased hypermutation and other genetic changes in defective measles viruses in human brain infections	1988-10-21		.txt	text/plain	7642	306	50	Abstract We assessed the alterations of viral gene expression occurring during persistent infections by cloning full-length transcripts of measles virus (MV) genes from brain autopsies of two subacute sclerosing panencephalitis patients and one measles inclusion body encephalitis (MIBE) patient. One of these nucleotide substitutions and one deletion resulted in alteration of the reading frames of two fusion genes, as confirmed by in vitro translation of synthetic mRNAs. One cluster of mutations was exceptional; in the matrix gene of the MIBE case, 50% of the U residues were changed to C, which might result from a highly biased copying event exclusively affecting this gene. most likely based on one hand on the low fidelity of RNA To assess the variability in strains of lytic viruses, and replication (Domingo et al., 1978; for review see Steinto estimate the number of mutations introduced during hauer and Holland, 1987) and on the other hand on the persistence, we counted the differences of lytic and perlow selective pressure exerted on viral genomes in nonsistent viruses from a consensus as defined above.	./cache/cord-263468-996kl9jz.txt	./txt/cord-263468-996kl9jz.txt