id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267036-llngs3v5	Lai, Ming‐Chih	Functional interplay between viral and cellular SR proteins in control of post‐transcriptional gene regulation	2009-02-10		.txt	text/plain	4460	263	44	Numerous lines of evidence indicate that cellular SR proteins are important for regulation of viral RNA splicing and participate in other steps of post-transcriptional viral gene expression control. The E2 protein encoded by HPVs primarily regulates the transcription of early promoters by binding to a consensus element within the long control region of the viral genome, and also functions together with the E1 protein in viral DNA replication [16] . It has been shown that reduced activity of SR proteins resulting from viral infection can be recovered by overexpression of SR proteins or by their rephosphorylation in the host cells [74] , and that HIV expression can be greatly increased when SRp75 is phosphorylated by SRPK2 [69] . Cellular SR proteins and their cooperative or antagonistic factors may play a critical role in the life cycle control of viruses, which involves a series of alternative splicing events for expression of viral genome or proteins. HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splcing and virus production in macrophages	./cache/cord-267036-llngs3v5.txt	./txt/cord-267036-llngs3v5.txt