id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268071-ow2aijmj	Pachetti, Maria	Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant	2020-04-22		.txt	text/plain	4449	236	53	Virus mutagenic capability depends upon several factors, including the fidelity of viral enzymes that replicate nucleic acids, as SARS-CoV-2 RNA dependent RNA polymerase (RdRp). Consequently, it is important to study and characterize SARS-CoV-2 RdRp mutation in order to assess possible drug-resistance viral phenotypes. Naturally occurring mutations in critical residues for drug efficacy can lead to drug resistance phenomena, with a significant loss in the binding affinity of these molecules to the RdRp. We focused our study on SARS-CoV-2 mutations in order to assess if new viral variants were spreading across the Countries. Among all mutation sites analyzed, RdRp mutant is particularly interesting given that the enzyme is directly involved in viral replication and its fidelity determines the mutagenic capabilities of SARS-CoV-2. In the present work we have compared the SARS-CoV-2 reference genome to those exported from the GISAID database with the aim of gaining important insights into virus mutations, their occurrence over time and within different geographic areas.	./cache/cord-268071-ow2aijmj.txt	./txt/cord-268071-ow2aijmj.txt