id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268763-s16n7f17	Williams, J. G.	Identification of Three Endotypes in Pediatric Acute Respiratory Distress Syndrome by Nasal Transcriptomic Profiling	2020-05-02		.txt	text/plain	4791	270	48	The sequences from these specimens was used for downstream analysis (Figure 1) Assessing Nasal Specimen Similarity 64 nasal brushing specimens from 15 PARDS and 10 control subjects collected on study days 1, 3, 7, and 14, were analyzed by DESeq2. In comparing Group A, B, and C subjects, only disease severity (PELOD2) was statistically significant (Supplemental Table 1 ), and for individual specimens, PARDS classification (None, Mild, Moderate, or Severe), and the presence of direct lung injury, a viral or combined viral/bacterial cause of ARDS were significantly different between groups A, B, and C (Supplemental Table 2 ). Interferon-γ and tumor necrosis factor-related signaling were notable in Group B ( in conjunction with our findings that the only clinical variables that differentiated specimens from groups B and C from A were severity of lung injury and a viral cause of ARDS, and that viruses were the most common trigger of ARDS in both groups B and C, these data demonstrate that nasal epithelial transcriptomics can identify three distinct endotypes in PARDS: Endotypes A, B, and C.	./cache/cord-268763-s16n7f17.txt	./txt/cord-268763-s16n7f17.txt