id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-271972-qhr6iir6	Gaglia, Marta Maria	Viruses and the cellular RNA decay machinery	2010-05-06		.txt	text/plain	6580	393	48	[10] [11] [12] [13] [14] While the role of the Lsm proteins in eukaryotes is closely linked to mRNA degradation, several viruses use this complex instead to facilitate viral replication and, surprisingly, to enhance viral RNA stability. 25 It is notable that the virus-associated roles of the Lsm complex in mRNA stabilization, enhanced translation, and replication are at odds with its established cellular function in activating mRNA decapping to facilitate message degradation. However, the zinc-finger antiviral protein (ZAP), an important mediator of cellular response to retroviruses, 39 alphaviruses, 40 and filoviruses, 41 has been shown to bind the hRrp46 component of the exosome and to recruit the complex to viral mRNAs to promote their degradation. Nonetheless, given the widespread roles for the exosome in RNA quality control and turnover, viruses presumably activate this complex at least indirectly when triggering turnover of cellular mRNAs. For example, infection by select herpes and coronaviruses results in a global destruction of host messages.	./cache/cord-271972-qhr6iir6.txt	./txt/cord-271972-qhr6iir6.txt