id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276575-jfug80yu	Aigner, Achim	Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo	2007-04-25		.txt	text/plain	5251	325	47	From the mechanism, it becomes clear that small interfering RNAs (siRNAs) play a pivotal role in triggering RNAi. Thus, the efficient delivery of target gene-specific siRNAs is one major challenge in the establishment of therapeutic RNAi. Numerous studies, based on different modes of administration and various siRNA formulations and/or modifications, have already accumulated promising results. While the inhibition of the activity of (aberrant) gene products, e.g., through small molecule inhibitors or inhibitory antibodies is one major focus in therapy, much attention has now shifted to an earlier step, i.e., the initial knockdown of the specific gene of interest through RNAi. However, for the in vivo application of RNAi in mammals as a therapeutic approach for reversing a pathological condition as well as for the study of particular gene functions, sophisticated strategies for the induction of RNAi are needed. RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo	./cache/cord-276575-jfug80yu.txt	./txt/cord-276575-jfug80yu.txt