id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-278647-krh63hqp	Carter, Robert W	A new look at an old virus: patterns of mutation accumulation in the human H1N1 influenza virus since 1918	2012-10-12		.txt	text/plain	8413	425	52	At the time of its disappearance in 2009, the human H1N1 lineage had accumulated over 1400 point mutations (more than 10% of the genome), including approximately 330 non-synonymous changes (7.4% of all codons). This process may play a role in natural pandemic cessation and has apparently contributed to the exponential decline in mortality rates over time, as seen in all major human influenza strains. Given this large body of data, it becomes feasible to test the attenuation model using mutation accumulation rates, non-synonymous amino acid changes, changing dN/dS ratios, changing transition/transversions ratios, and changes in codon specificity over time. Using the amended 1918 Brevig Mission virus as a reference and including all human and porcine viruses in the database, we calculated SNPs, indels, transitions, transversions, non-synonymous amino acid changes, dN/dS ratios, predicted protein lengths (for all 11 proteins), the normalized codon scores (NCS) and relative synonymous codon usage (RSCU) [51] score for each predicted protein of each genome.	./cache/cord-278647-krh63hqp.txt	./txt/cord-278647-krh63hqp.txt