id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279841-oq25o4qr	Ahlquist, Paul	Viral and host determinants of RNA virus vector replication and expression	2005-03-07		.txt	text/plain	2269	99	36	Further insights into RNA virus vector design and optimization are emerging from recent advances on the function of viral RNA replication factors, the nature of the viral RNA replication complex as a membrane-bounded compartment sequestering replication components from competing processes and host defenses, and identification of surprisingly diverse host genes contributing to many virus replication steps. An unusual feature of BMV for identifying and characterizing host functions in viral replication is that BMV directs RNA replication, gene expression and virion formation in the genetic model yeast, Saccharomyces cerevisiae [13] . In recent years, classical yeast genetics have been used to identify host genes that function in controlling BMV translation [14, 15] , selecting BMV RNAs as replication templates [16] , activating the viral RNA replication complex [17] , maintaining a lipid composition required for membrane-associated RNA replication [18, 19] , and other steps.	./cache/cord-279841-oq25o4qr.txt	./txt/cord-279841-oq25o4qr.txt