id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280616-9mwr6a4x	Yang, Ying	Small non-coding RNAs-based bone regulation and targeting therapeutic strategies	2017-11-15		.txt	text/plain	16961	828	36	reported a mechanosensitive miRNA, hsa-miR-103a-3p, that exhibited negative effects on Runx2 during cyclic mechanical stretch (CMS)induced osteoblastogenesis, leading to decreased bone formation both in vitro and in vivo (Zuo et al., 2015) . To understand whether other effective paracrine pathways exist in the interaction between the two cell types, Li and colleagues conducted miRNA-mediated osteoclast-directed osteoblastic bone formation in ovariectomized (OVX) mice, indicating that inhibition of osteoclast-derived exosomal mmu-miR-214-3p induced significantly suppressed osteoclastogenesis (Li et al., 2016b) . In addition, Krzeszinski and colleagues found that mmu-miR-34a-5p knockout and heterozygous mice exhibited elevated bone resorption and reduced bone mass by targeting transforming growth factor-b-induced factor 2 (Tgif2), indicating that miR-34a-5p was a critical osteoclast suppressor and a potential therapeutic strategy to combat osteoporosis, and could exert both anti-catabolic and anabolic effects compared to current drugs that are solely anticatabolic (Krzeszinski et al., 2014) .	./cache/cord-280616-9mwr6a4x.txt	./txt/cord-280616-9mwr6a4x.txt