id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-286243-ddpemgqt	Whitaker, Amy M.	APE1: A skilled nucleic acid surgeon	2018-11-30		.txt	text/plain	5842	274	41	One such factor is the multifunctional enzyme human apurinic/apyrimidinic endonuclease 1 (APE1), known best for its DNA backbone cleavage activity at AP sites during base excision repair (BER). Abbreviations: 1-nt, 1-nucleotide; 5OHU, 5-hydroxy-2′-deoxyuridine; 8-oxoG, 8-oxoGuanine; AP, apurinic/apyrimidinic; APE1, human apurinic/apyrimidinic endonuclease 1; APE2, apurinic/apyrimidinic endonuclease 2; BER, base excision repair; DHT, 5,6-dihydrothymidine; DHU, 5,6-dihydro-2′-deoxyuridine; dRP, deoxyribonucleotide-phosphate; IR, ionizing radiation; NIR, nucleotide incision repair; pBQ-C, benzetheno exocyclic adduct of cytosine; PG, phosphoglycolate; PNK, polynucleotide kinase; PUA, α,β-unsaturated aldehyde; ROS, reactive oxygen species; THF, tetrahydrofuran; Tdp1, tyrosyl-DNA phosphodiesterase 1; XRCC1, X-ray repair cross-complementing protein 1 ⁎ Corresponding author. The BER pathway requires the coordinated activity of at least five enzymes including: (1) a DNA glycosylase capable of excising the modified base; (2) an AP-endonuclease, such as APE1, to generate a nick at the lesion site; (3) DNA polymerase β, which performs both lyase and DNA synthesis activities to remove the 5′ dRP (deoxyribonucleotide-phosphate) and fill the resulting gap; and, finally (4) DNA ligase III and (5) XRCC1 (X-ray repair cross-complementing protein 1) scaffolding to seal the nick and complete the repair, (Fig. 1) .	./cache/cord-286243-ddpemgqt.txt	./txt/cord-286243-ddpemgqt.txt