id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293355-0v71xwqy	Aguiar, Eric Roberto Guimarães Rocha	Virus‐derived small RNAs: molecular footprints of host–pathogen interactions	2016-05-12		.txt	text/plain	6830	446	50	Thus, the pattern of small RNAs generated in infected cells can be used as a molecular footprint to identify and characterize viruses independent on sequence homology searches against known references. Different RNAi mechanisms can generate vsRNAs during viral infection including the mammalian miRNA pathway, Drosophila small interfering RNA (siRNA) pathway, and mosquito piRNA pathway. 22, 23 In animals, there are at least three separate RNAi mechanisms that can generate vsRNAs during viral infection: the microRNA (miRNA), piwi-interacting RNA (piRNA), and small interfering RNA (siRNA) pathways ( Figure 1 ). Interestingly, EVEs seemed to favor the generation of small RNAs with molecular characteristics of piRNAs rather than siRNAs. Second, some viruses have developed viral suppressors of the siRNA pathway (VSRs) that can significantly affect the pattern of vsRNAs. VSRs allow for accumulation of viral RNA that can be degraded by other host mechanisms.	./cache/cord-293355-0v71xwqy.txt	./txt/cord-293355-0v71xwqy.txt