id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294764-v28wbrqp	Deval, Jerome	Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses	2017-04-15		.txt	text/plain	8316	433	46	The in vitro assays and in vivo animal models that have been developed to identify and characterize inhibitors of norovirus RdRp are also summarized, followed by an update on the current antiviral research targeting different regions of norovirus RdRp. In the future, structure-based drug design and rational optimization of known nucleoside and non-nucleoside inhibitors of norovirus RdRp may pave the way towards the next generation of direct-acting antivirals. Despite this limitation, the in vitro effect of small molecules on HuNoV replication has been studied using a stable human hepatoma cell line expressing the part of the Norwalk virus RNA genome encoding the non-structural proteins and carrying the neomycin resistance gene (Chang et al., 2006) . Finally, since norovirus RdRp shares functional and structural features with proteins from other RNA viruses such as HCV, it may be possible to identify nucleo(s/t)ide analogs, like 2CM-C, which inhibits a range of viral polymerases.	./cache/cord-294764-v28wbrqp.txt	./txt/cord-294764-v28wbrqp.txt