id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297579-ohpm5ys0	Netzler, Natalie E.	Norovirus antivirals: Where are we now?	2018-12-25		.txt	text/plain	6471	375	37	Despite the clinical significance of norovirus infection, antiviral studies have been hindered, because until recently, human norovirus could not be successfully propagated in cell culture. The cross-genotypic activity displayed by Nbs illustrates that these molecules have the potential to overcome the narrow antigenic spectrum typically displayed by conventional mAbs. However, despite these findings, mAb and Nb studies have been based mostly on VLP-binding and structural analysis of that binding (Table 1 ) and thus the effects of such compounds against norovirus in cell culture or in vivo need to be explored further before continued development toward clinical application. Most recently NTZ was shown to potently inhibit FCV replication in cell culture with an EC 50 of 0.6 µM, 189 and the GI norovirus replicon at a clinically relevant concentration (5 μg/mL), 190 which was later shown to result in a broad antiviral response. The viral polymerase inhibitor 2′-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model	./cache/cord-297579-ohpm5ys0.txt	./txt/cord-297579-ohpm5ys0.txt