id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319821-ij34t1ae	Bauer, Lisa	Direct-acting antivirals and host-targeting strategies to combat enterovirus infections	2017-04-12		.txt	text/plain	4041	235	40	Here, we will review recent efforts to develop direct-acting antivirals as well as host factor-targeting inhibitors to treat enterovirus infections (Table 1) . 2C ATPase and 3D pol may be more promising targets for direct-acting antiviral drugs as they can be inhibited by small molecules, and several inhibitors of these factors were found to have broad-range anti-enteroviral activity. Since targeted drug discovery depends heavily on basic knowledge of virus replication, fundamental research on the role of viral enzymes as well as essential host factors for enterovirus replication remains needed for the development of broad-range antiviral drugs against these important pathogens. FDA-aroved drug to target fungal infections, is identified as a broad-spectrum enterovirus inhibitor and shown to target the lipid shuttling activity of oxysterol-binding protein that is essential for viral replication organell formation and/or function	./cache/cord-319821-ij34t1ae.txt	./txt/cord-319821-ij34t1ae.txt