id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328737-6mcefqn5	Lee, Eun Yeong	A novel nucleic acid amplification system based on nano-gap embedded active disk resonators	2020-05-26		.txt	text/plain	4147	181	45	We here describe for the first time a novel nucleic acid amplification system based on nano-gap active resonators that can be used for in various molecular diagnostic applications, which requires a label-free and real-time detection with rapidity and high sensitivity. First, SRSN active disk resonators were used as photoluminescence sensors for the PL peaks J o u r n a l P r e -p r o o f generated by the direct amplification of nucleic acids on the sensor surface in a label-free and real-time manner. These complexes bind to the target nucleic acids and enable the strand exchange which will begin the amplification process both on the surface of disk resonator (solid) and solution simultaneously ( Fig. 1-rectangle) , with the temperature maintained at isothermal conditions (38°C or 43°C for DNA or RNA, respectively). This photoluminescence sensor enables label-free and real-time amplification and direct detection of either bacterial DNA or viral RNA on the resonator surface.	./cache/cord-328737-6mcefqn5.txt	./txt/cord-328737-6mcefqn5.txt