id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329107-43e2lkht	Pawlicka, Kamila	Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics	2020-03-24		.txt	text/plain	6690	377	44	Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a surveillance pathway used by cells to control the quality mRNAs and to fine-tune transcript abundance. Disturbance of this control mechanism caused by genetic mutations or dys-regulation of the NMD pathway can lead to pathologies, including neurological disorders, immune diseases and cancers. Nonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that recognizes and eliminates aberrant RNAs containing premature termination codons (PTC) or abnormally long 3 untranslated regions (UTRs). Nonsense-mediated mRNA decay is a critical RNA quality control and plays a vital role in the recognition of PTCs in transcripts, as well as in the regular homeostasis of the transcriptome. Understanding the mechanism of nonsense-mediated mRNA decay might lead to new ways to use surveillance in cancer therapy or other PTC-associated genetic diseases. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon Hypoxic Inhibition of Nonsense-Mediated RNA Decay Regulates Gene Expression and the Integrated Stress Response	./cache/cord-329107-43e2lkht.txt	./txt/cord-329107-43e2lkht.txt