id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331066-ediowz4s	Chechetkin, Vladimir R.	Ribonucleocapsid assembly/packaging signals in the genomes of the coronaviruses SARS-CoV and SARS-CoV-2: detection, comparison and implications for therapeutic targeting	2020-09-09		.txt	text/plain	7040	416	57	Due to transitional symmetry of a helix, weakly specific cooperative interaction between ssRNA and nucleocapsid proteins leads to the natural selection of specific quasi-periodic assembly/packaging signals in the related genomic sequence. Therefore, the putative weakly specific assembly/packaging signals in the genomic RNA of coronaviruses should be coordinated with the parameters of the helical nucleocapsid (such as the helix pitch, inner and outer diameters) which are established by cryoelectron microscopy (cryo-EM) and other structural methods. In this article, we provide methods for the detection and comparative analysis of assembly/packaging signals in the genomic RNA of the coronaviruses SARS-CoV and SARS-CoV-2 and describe main results of our study. The abundance of quasi-periodic patterns in the genomic DNA/RNA sequences can be assessed by the spectral entropy (Balakirev et al., 2003 (Balakirev et al., , 2005 (Balakirev et al., , 2014 Chechetkin, 2011; Chechetkin & Lobzin, 1996; Chechetkin & Turygin, 1994) .	./cache/cord-331066-ediowz4s.txt	./txt/cord-331066-ediowz4s.txt