id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331076-ak481qew	Eskier, Doğa	Mutations of SARS-CoV-2 nsp14 exhibit strong association with increased genome-wide mutation load	2020-10-12		.txt	text/plain	3858	192	52	In our previous study, we examined the top 10 most frequent mutations in the SARS-CoV-2 nsp12, and identified that four of them are associated with an increase in mutation density in two genes, the membrane glycoprotein (M) and the envelope glycoprotein (E) (the combination of which is hereafter referred to as MoE, as we previously described), which are under less selective pressure, and mutations in these genes are potential markers of reduced replication fidelity (Eskier et al., 2020a) . To identify the trends in SARS-CoV-2 mutation load over time, we calculated the average mutation density per day for all isolates for whole genome, S gene and MoE regions, capping outliers at the 95th and 5th percentile values to minimize the potential effects of sequencing errors (Fig. 1) . Three of the five most common nsp14 mutations, namely 18060C>T, 18736T>C and 18877C>T are associated with increases in both genome-wide mutational load, as well as MoE status, an alternative indicator of mutational rate and virus evolution.	./cache/cord-331076-ak481qew.txt	./txt/cord-331076-ak481qew.txt