id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332006-if46jycd	Whitehead, Kathryn A.	Knocking down barriers: advances in siRNA delivery	2009		.txt	text/plain	6655	391	42	Three years later, Tuschl and co-workers published their celebrated proof-of-principle experiment demonstrating that synthetic small interfering RNA (siRNA) could achieve sequence-specific gene knockdown in a mammalian cell line 2 . Toxicity of certain cationic lipid particles has been reported both in vitro and in vivo [76] [77] [78] , and certain synthetic agents have been found to induce a gene signature of their own that might increase the off-target effects of siRNA 79, 80 . Tumour growth in a mouse model of metastatic Ewing's sarcoma was shown to be inhibited by the systemic delivery of nanoparticles formed by cyclodextrin, the targeting ligand transferrin, and siRNA specific for the EWS-FLI1 fusion gene commonly associated with the condition. Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity	./cache/cord-332006-if46jycd.txt	./txt/cord-332006-if46jycd.txt