id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335040-1qa6pe4v	Rogstam, Annika	Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2	2020-10-06		.txt	text/plain	7408	385	59	The SARS-CoV-2 non-structural protein 10 (nsp10) displays high sequence similarity with its SARS homologue, which binds to and stimulates the 3′-to-5′ exoribonuclease and the 2′-O-methlytransferase activities of nsps 14 and 16, respectively. The crystal structure and solution behaviour of nsp10 will not only form the basis for understanding the role of SARS-CoV-2 nsp10 as a central player of the viral RNA capping apparatus, but will also serve as a basis for the development of inhibitors of nsp10, interfering with crucial functions of the replication–transcription complex and virus replication. observed SARS nsp10 in the same space group as reported here, I213, reporting a monomer in the asymmetric unit but a dimer in solution, as was determined by size exclusion Residues shaded in red are fully conserved, while residues with text in red indicate a change to a similar residue. We determined the crystal structure and behaviour in solution of SARS-CoV-2 nsp10 in its unbound form.	./cache/cord-335040-1qa6pe4v.txt	./txt/cord-335040-1qa6pe4v.txt