id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350533-fp1ctpax	Tchesnokov, Egor P.	Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein	2020-06-04		.txt	text/plain	6033	346	50	Moreover, we identified 2'-deoxy-2'-amino-CTP as a novel inhibitor of CCHFV RdRp. We further show that CC.4 inhibits the CCHFV-associated DUB activity of the full-length L protein and the isolated DUB domain to a similar extent. Inhibition of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein ribavirin-TP or favipiravir-TP are also used as substrates opposite template C (Fig 3, middle) . Inhibition of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein CCHFV L full-length protein and the isolated OTU domain cleave ubiquitin-AMC in a time dependent manner with similar velocities illustrated by the slopes of the initial linear portion of product formation (Fig 8B) . The identification of small molecule compounds that inhibit viral RNA synthesis relies on the availability of recombinant L protein, which is a multifunctional protein with a high molecular weight of~450 kDa. Here we report the expression of full-length CCHFV L protein that possess active RdRp and DUB domains.	./cache/cord-350533-fp1ctpax.txt	./txt/cord-350533-fp1ctpax.txt