id sid tid token lemma pos cord-267475-6f4h3cck 1 1 key key JJ cord-267475-6f4h3cck 1 2 : : : cord-267475-6f4h3cck 1 3 cord-267475 cord-267475 NNP cord-267475-6f4h3cck 1 4 - - HYPH cord-267475-6f4h3cck 1 5 6f4h3cck 6f4h3cck NNP cord-267475-6f4h3cck 2 1 authors author NNS cord-267475-6f4h3cck 2 2 : : : cord-267475-6f4h3cck 2 3 Kozak Kozak NNP cord-267475-6f4h3cck 2 4 , , , cord-267475-6f4h3cck 2 5 Marilyn Marilyn NNP cord-267475-6f4h3cck 2 6 title title NN cord-267475-6f4h3cck 2 7 : : : cord-267475-6f4h3cck 2 8 Pushing push VBG cord-267475-6f4h3cck 2 9 the the DT cord-267475-6f4h3cck 2 10 limits limit NNS cord-267475-6f4h3cck 2 11 of of IN cord-267475-6f4h3cck 2 12 the the DT cord-267475-6f4h3cck 2 13 scanning scanning NN cord-267475-6f4h3cck 2 14 mechanism mechanism NN cord-267475-6f4h3cck 2 15 for for IN cord-267475-6f4h3cck 2 16 initiation initiation NN cord-267475-6f4h3cck 2 17 of of IN cord-267475-6f4h3cck 2 18 translation translation NN cord-267475-6f4h3cck 2 19 date date NN cord-267475-6f4h3cck 2 20 : : : cord-267475-6f4h3cck 2 21 2002 2002 CD cord-267475-6f4h3cck 2 22 - - SYM cord-267475-6f4h3cck 2 23 10 10 CD cord-267475-6f4h3cck 2 24 - - SYM cord-267475-6f4h3cck 2 25 16 16 CD cord-267475-6f4h3cck 2 26 journal journal NN cord-267475-6f4h3cck 2 27 : : : cord-267475-6f4h3cck 3 1 Gene gene NN cord-267475-6f4h3cck 3 2 DOI DOI NNP cord-267475-6f4h3cck 3 3 : : : cord-267475-6f4h3cck 3 4 10.1016 10.1016 CD cord-267475-6f4h3cck 3 5 / / SYM cord-267475-6f4h3cck 3 6 s0378 s0378 NN cord-267475-6f4h3cck 3 7 - - HYPH cord-267475-6f4h3cck 3 8 1119(02)01056 1119(02)01056 NNP cord-267475-6f4h3cck 3 9 - - SYM cord-267475-6f4h3cck 3 10 9 9 CD cord-267475-6f4h3cck 4 1 sha sha NNP cord-267475-6f4h3cck 4 2 : : : cord-267475-6f4h3cck 5 1 97c78798cc75c9da5716e5c6e7c61f8b703ccadf 97c78798cc75c9da5716e5c6e7c61f8b703ccadf CD cord-267475-6f4h3cck 5 2 doc_id doc_id CD cord-267475-6f4h3cck 6 1 : : : cord-267475-6f4h3cck 6 2 267475 267475 CD cord-267475-6f4h3cck 6 3 cord_uid cord_uid NNS cord-267475-6f4h3cck 6 4 : : : cord-267475-6f4h3cck 7 1 6f4h3cck 6f4h3cck CD cord-267475-6f4h3cck 7 2 Selection selection NN cord-267475-6f4h3cck 7 3 of of IN cord-267475-6f4h3cck 7 4 the the DT cord-267475-6f4h3cck 7 5 translational translational JJ cord-267475-6f4h3cck 7 6 initiation initiation NN cord-267475-6f4h3cck 7 7 site site NN cord-267475-6f4h3cck 7 8 in in IN cord-267475-6f4h3cck 7 9 most most JJS cord-267475-6f4h3cck 7 10 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 7 11 mRNAs mRNAs NNPS cord-267475-6f4h3cck 7 12 appears appear VBZ cord-267475-6f4h3cck 7 13 to to TO cord-267475-6f4h3cck 7 14 occur occur VB cord-267475-6f4h3cck 7 15 via via IN cord-267475-6f4h3cck 7 16 a a DT cord-267475-6f4h3cck 7 17 scanning scanning NN cord-267475-6f4h3cck 7 18 mechanism mechanism NN cord-267475-6f4h3cck 7 19 which which WDT cord-267475-6f4h3cck 7 20 predicts predict VBZ cord-267475-6f4h3cck 7 21 that that IN cord-267475-6f4h3cck 7 22 proximity proximity NN cord-267475-6f4h3cck 7 23 to to IN cord-267475-6f4h3cck 7 24 the the DT cord-267475-6f4h3cck 7 25 5′ 5′ CD cord-267475-6f4h3cck 7 26 end end NN cord-267475-6f4h3cck 7 27 plays play VBZ cord-267475-6f4h3cck 7 28 a a DT cord-267475-6f4h3cck 7 29 dominant dominant JJ cord-267475-6f4h3cck 7 30 role role NN cord-267475-6f4h3cck 7 31 in in IN cord-267475-6f4h3cck 7 32 identifying identify VBG cord-267475-6f4h3cck 7 33 the the DT cord-267475-6f4h3cck 7 34 start start NN cord-267475-6f4h3cck 7 35 codon codon NN cord-267475-6f4h3cck 7 36 . . . cord-267475-6f4h3cck 8 1 This this DT cord-267475-6f4h3cck 8 2 ‘ ' `` cord-267475-6f4h3cck 8 3 position position NN cord-267475-6f4h3cck 8 4 effect effect NN cord-267475-6f4h3cck 8 5 ’ ' '' cord-267475-6f4h3cck 8 6 is be VBZ cord-267475-6f4h3cck 8 7 seen see VBN cord-267475-6f4h3cck 8 8 in in IN cord-267475-6f4h3cck 8 9 cases case NNS cord-267475-6f4h3cck 8 10 where where WRB cord-267475-6f4h3cck 8 11 a a DT cord-267475-6f4h3cck 8 12 mutation mutation NN cord-267475-6f4h3cck 8 13 creates create VBZ cord-267475-6f4h3cck 8 14 an an DT cord-267475-6f4h3cck 8 15 AUG AUG NNP cord-267475-6f4h3cck 8 16 codon codon NN cord-267475-6f4h3cck 8 17 upstream upstream RB cord-267475-6f4h3cck 8 18 from from IN cord-267475-6f4h3cck 8 19 the the DT cord-267475-6f4h3cck 8 20 normal normal JJ cord-267475-6f4h3cck 8 21 start start NN cord-267475-6f4h3cck 8 22 site site NN cord-267475-6f4h3cck 8 23 and and CC cord-267475-6f4h3cck 8 24 translation translation NN cord-267475-6f4h3cck 8 25 shifts shift NNS cord-267475-6f4h3cck 8 26 to to IN cord-267475-6f4h3cck 8 27 the the DT cord-267475-6f4h3cck 8 28 upstream upstream JJ cord-267475-6f4h3cck 8 29 site site NN cord-267475-6f4h3cck 8 30 . . . cord-267475-6f4h3cck 9 1 The the DT cord-267475-6f4h3cck 9 2 position position NN cord-267475-6f4h3cck 9 3 effect effect NN cord-267475-6f4h3cck 9 4 is be VBZ cord-267475-6f4h3cck 9 5 evident evident JJ cord-267475-6f4h3cck 9 6 also also RB cord-267475-6f4h3cck 9 7 in in IN cord-267475-6f4h3cck 9 8 cases case NNS cord-267475-6f4h3cck 9 9 where where WRB cord-267475-6f4h3cck 9 10 a a DT cord-267475-6f4h3cck 9 11 silent silent JJ cord-267475-6f4h3cck 9 12 internal internal JJ cord-267475-6f4h3cck 9 13 AUG AUG NNP cord-267475-6f4h3cck 9 14 codon codon NN cord-267475-6f4h3cck 9 15 is be VBZ cord-267475-6f4h3cck 9 16 activated activate VBN cord-267475-6f4h3cck 9 17 upon upon IN cord-267475-6f4h3cck 9 18 being be VBG cord-267475-6f4h3cck 9 19 relocated relocate VBN cord-267475-6f4h3cck 9 20 closer close RBR cord-267475-6f4h3cck 9 21 to to IN cord-267475-6f4h3cck 9 22 the the DT cord-267475-6f4h3cck 9 23 5′ 5′ CD cord-267475-6f4h3cck 9 24 end end NN cord-267475-6f4h3cck 9 25 . . . cord-267475-6f4h3cck 10 1 Two two CD cord-267475-6f4h3cck 10 2 mechanisms mechanism NNS cord-267475-6f4h3cck 10 3 for for IN cord-267475-6f4h3cck 10 4 escaping escape VBG cord-267475-6f4h3cck 10 5 the the DT cord-267475-6f4h3cck 10 6 first first JJ cord-267475-6f4h3cck 10 7 - - HYPH cord-267475-6f4h3cck 10 8 AUG AUG NNP cord-267475-6f4h3cck 10 9 rule rule NN cord-267475-6f4h3cck 10 10 – – : cord-267475-6f4h3cck 10 11 reinitiation reinitiation NN cord-267475-6f4h3cck 10 12 and and CC cord-267475-6f4h3cck 10 13 context context NN cord-267475-6f4h3cck 10 14 - - HYPH cord-267475-6f4h3cck 10 15 dependent dependent JJ cord-267475-6f4h3cck 10 16 leaky leaky JJ cord-267475-6f4h3cck 10 17 scanning scanning NN cord-267475-6f4h3cck 10 18 – – : cord-267475-6f4h3cck 10 19 enable enable VB cord-267475-6f4h3cck 10 20 downstream downstream JJ cord-267475-6f4h3cck 10 21 AUG AUG NNP cord-267475-6f4h3cck 10 22 codons codon NNS cord-267475-6f4h3cck 10 23 to to TO cord-267475-6f4h3cck 10 24 be be VB cord-267475-6f4h3cck 10 25 accessed access VBN cord-267475-6f4h3cck 10 26 in in IN cord-267475-6f4h3cck 10 27 some some DT cord-267475-6f4h3cck 10 28 mRNAs mrna NNS cord-267475-6f4h3cck 10 29 . . . cord-267475-6f4h3cck 11 1 Although although IN cord-267475-6f4h3cck 11 2 these these DT cord-267475-6f4h3cck 11 3 mechanisms mechanism NNS cord-267475-6f4h3cck 11 4 are be VBP cord-267475-6f4h3cck 11 5 not not RB cord-267475-6f4h3cck 11 6 new new JJ cord-267475-6f4h3cck 11 7 , , , cord-267475-6f4h3cck 11 8 many many JJ cord-267475-6f4h3cck 11 9 new new JJ cord-267475-6f4h3cck 11 10 examples example NNS cord-267475-6f4h3cck 11 11 of of IN cord-267475-6f4h3cck 11 12 their -PRON- PRP$ cord-267475-6f4h3cck 11 13 use use NN cord-267475-6f4h3cck 11 14 have have VBP cord-267475-6f4h3cck 11 15 emerged emerge VBN cord-267475-6f4h3cck 11 16 . . . cord-267475-6f4h3cck 12 1 Via via IN cord-267475-6f4h3cck 12 2 these these DT cord-267475-6f4h3cck 12 3 escape escape NN cord-267475-6f4h3cck 12 4 pathways pathway NNS cord-267475-6f4h3cck 12 5 , , , cord-267475-6f4h3cck 12 6 the the DT cord-267475-6f4h3cck 12 7 scanning scanning NN cord-267475-6f4h3cck 12 8 mechanism mechanism NN cord-267475-6f4h3cck 12 9 operates operate VBZ cord-267475-6f4h3cck 12 10 even even RB cord-267475-6f4h3cck 12 11 in in IN cord-267475-6f4h3cck 12 12 extreme extreme JJ cord-267475-6f4h3cck 12 13 cases case NNS cord-267475-6f4h3cck 12 14 , , , cord-267475-6f4h3cck 12 15 such such JJ cord-267475-6f4h3cck 12 16 as as IN cord-267475-6f4h3cck 12 17 a a DT cord-267475-6f4h3cck 12 18 plant plant NN cord-267475-6f4h3cck 12 19 virus virus NN cord-267475-6f4h3cck 12 20 mRNA mrna NN cord-267475-6f4h3cck 12 21 in in IN cord-267475-6f4h3cck 12 22 which which WDT cord-267475-6f4h3cck 12 23 translation translation NN cord-267475-6f4h3cck 12 24 initiates initiate VBZ cord-267475-6f4h3cck 12 25 from from IN cord-267475-6f4h3cck 12 26 three three CD cord-267475-6f4h3cck 12 27 start start NN cord-267475-6f4h3cck 12 28 sites site NNS cord-267475-6f4h3cck 12 29 over over IN cord-267475-6f4h3cck 12 30 a a DT cord-267475-6f4h3cck 12 31 distance distance NN cord-267475-6f4h3cck 12 32 of of IN cord-267475-6f4h3cck 12 33 900 900 CD cord-267475-6f4h3cck 12 34 nt nt RB cord-267475-6f4h3cck 12 35 . . . cord-267475-6f4h3cck 13 1 This this DT cord-267475-6f4h3cck 13 2 depends depend VBZ cord-267475-6f4h3cck 13 3 on on IN cord-267475-6f4h3cck 13 4 careful careful JJ cord-267475-6f4h3cck 13 5 structural structural JJ cord-267475-6f4h3cck 13 6 arrangements arrangement NNS cord-267475-6f4h3cck 13 7 , , , cord-267475-6f4h3cck 13 8 however however RB cord-267475-6f4h3cck 13 9 , , , cord-267475-6f4h3cck 13 10 which which WDT cord-267475-6f4h3cck 13 11 are be VBP cord-267475-6f4h3cck 13 12 rarely rarely RB cord-267475-6f4h3cck 13 13 present present JJ cord-267475-6f4h3cck 13 14 in in IN cord-267475-6f4h3cck 13 15 cellular cellular JJ cord-267475-6f4h3cck 13 16 mRNAs mrna NNS cord-267475-6f4h3cck 13 17 . . . cord-267475-6f4h3cck 14 1 Understanding understand VBG cord-267475-6f4h3cck 14 2 the the DT cord-267475-6f4h3cck 14 3 rules rule NNS cord-267475-6f4h3cck 14 4 for for IN cord-267475-6f4h3cck 14 5 initiation initiation NN cord-267475-6f4h3cck 14 6 of of IN cord-267475-6f4h3cck 14 7 translation translation NN cord-267475-6f4h3cck 14 8 enables enable VBZ cord-267475-6f4h3cck 14 9 understanding understanding NN cord-267475-6f4h3cck 14 10 of of IN cord-267475-6f4h3cck 14 11 human human JJ cord-267475-6f4h3cck 14 12 diseases disease NNS cord-267475-6f4h3cck 14 13 in in IN cord-267475-6f4h3cck 14 14 which which WDT cord-267475-6f4h3cck 14 15 the the DT cord-267475-6f4h3cck 14 16 expression expression NN cord-267475-6f4h3cck 14 17 of of IN cord-267475-6f4h3cck 14 18 a a DT cord-267475-6f4h3cck 14 19 critical critical JJ cord-267475-6f4h3cck 14 20 gene gene NN cord-267475-6f4h3cck 14 21 is be VBZ cord-267475-6f4h3cck 14 22 reduced reduce VBN cord-267475-6f4h3cck 14 23 by by IN cord-267475-6f4h3cck 14 24 mutations mutation NNS cord-267475-6f4h3cck 14 25 that that WDT cord-267475-6f4h3cck 14 26 add add VBP cord-267475-6f4h3cck 14 27 upstream upstream JJ cord-267475-6f4h3cck 14 28 AUG AUG NNP cord-267475-6f4h3cck 14 29 codons codon NNS cord-267475-6f4h3cck 14 30 or or CC cord-267475-6f4h3cck 14 31 change change VB cord-267475-6f4h3cck 14 32 the the DT cord-267475-6f4h3cck 14 33 context context NN cord-267475-6f4h3cck 14 34 around around IN cord-267475-6f4h3cck 14 35 the the DT cord-267475-6f4h3cck 14 36 AUG(START AUG(START NNP cord-267475-6f4h3cck 14 37 ) ) -RRB- cord-267475-6f4h3cck 14 38 codon codon NN cord-267475-6f4h3cck 14 39 . . . cord-267475-6f4h3cck 15 1 The the DT cord-267475-6f4h3cck 15 2 opposite opposite JJ cord-267475-6f4h3cck 15 3 problem problem NN cord-267475-6f4h3cck 15 4 occurs occur VBZ cord-267475-6f4h3cck 15 5 in in IN cord-267475-6f4h3cck 15 6 the the DT cord-267475-6f4h3cck 15 7 case case NN cord-267475-6f4h3cck 15 8 of of IN cord-267475-6f4h3cck 15 9 hereditary hereditary JJ cord-267475-6f4h3cck 15 10 thrombocythemia thrombocythemia NN cord-267475-6f4h3cck 15 11 : : : cord-267475-6f4h3cck 15 12 translational translational JJ cord-267475-6f4h3cck 15 13 efficiency efficiency NN cord-267475-6f4h3cck 15 14 is be VBZ cord-267475-6f4h3cck 15 15 increased increase VBN cord-267475-6f4h3cck 15 16 by by IN cord-267475-6f4h3cck 15 17 mutations mutation NNS cord-267475-6f4h3cck 15 18 that that WDT cord-267475-6f4h3cck 15 19 remove remove VBP cord-267475-6f4h3cck 15 20 or or CC cord-267475-6f4h3cck 15 21 restructure restructure VBP cord-267475-6f4h3cck 15 22 a a DT cord-267475-6f4h3cck 15 23 small small JJ cord-267475-6f4h3cck 15 24 upstream upstream NN cord-267475-6f4h3cck 15 25 open open JJ cord-267475-6f4h3cck 15 26 reading reading NN cord-267475-6f4h3cck 15 27 frame frame NN cord-267475-6f4h3cck 15 28 in in IN cord-267475-6f4h3cck 15 29 thrombopoietin thrombopoietin NNP cord-267475-6f4h3cck 15 30 mRNA mRNA NNP cord-267475-6f4h3cck 15 31 , , , cord-267475-6f4h3cck 15 32 and and CC cord-267475-6f4h3cck 15 33 the the DT cord-267475-6f4h3cck 15 34 resulting result VBG cord-267475-6f4h3cck 15 35 overproduction overproduction NN cord-267475-6f4h3cck 15 36 of of IN cord-267475-6f4h3cck 15 37 the the DT cord-267475-6f4h3cck 15 38 cytokine cytokine NN cord-267475-6f4h3cck 15 39 causes cause VBZ cord-267475-6f4h3cck 15 40 the the DT cord-267475-6f4h3cck 15 41 disease disease NN cord-267475-6f4h3cck 15 42 . . . cord-267475-6f4h3cck 16 1 This this DT cord-267475-6f4h3cck 16 2 and and CC cord-267475-6f4h3cck 16 3 other other JJ cord-267475-6f4h3cck 16 4 examples example NNS cord-267475-6f4h3cck 16 5 support support VBP cord-267475-6f4h3cck 16 6 the the DT cord-267475-6f4h3cck 16 7 idea idea NN cord-267475-6f4h3cck 16 8 that that IN cord-267475-6f4h3cck 16 9 5′ 5′ CD cord-267475-6f4h3cck 16 10 leader leader NN cord-267475-6f4h3cck 16 11 sequences sequence NNS cord-267475-6f4h3cck 16 12 are be VBP cord-267475-6f4h3cck 16 13 sometimes sometimes RB cord-267475-6f4h3cck 16 14 structured structure VBN cord-267475-6f4h3cck 16 15 deliberately deliberately RB cord-267475-6f4h3cck 16 16 in in IN cord-267475-6f4h3cck 16 17 a a DT cord-267475-6f4h3cck 16 18 way way NN cord-267475-6f4h3cck 16 19 that that WDT cord-267475-6f4h3cck 16 20 constrains constrain VBZ cord-267475-6f4h3cck 16 21 scanning scanning NN cord-267475-6f4h3cck 16 22 in in IN cord-267475-6f4h3cck 16 23 order order NN cord-267475-6f4h3cck 16 24 to to TO cord-267475-6f4h3cck 16 25 prevent prevent VB cord-267475-6f4h3cck 16 26 harmful harmful JJ cord-267475-6f4h3cck 16 27 overproduction overproduction NN cord-267475-6f4h3cck 16 28 of of IN cord-267475-6f4h3cck 16 29 potent potent JJ cord-267475-6f4h3cck 16 30 regulatory regulatory JJ cord-267475-6f4h3cck 16 31 proteins protein NNS cord-267475-6f4h3cck 16 32 . . . cord-267475-6f4h3cck 17 1 The the DT cord-267475-6f4h3cck 17 2 accumulated accumulate VBN cord-267475-6f4h3cck 17 3 evidence evidence NN cord-267475-6f4h3cck 17 4 reveals reveal VBZ cord-267475-6f4h3cck 17 5 how how WRB cord-267475-6f4h3cck 17 6 the the DT cord-267475-6f4h3cck 17 7 scanning scanning NN cord-267475-6f4h3cck 17 8 mechanism mechanism NN cord-267475-6f4h3cck 17 9 dictates dictate VBZ cord-267475-6f4h3cck 17 10 the the DT cord-267475-6f4h3cck 17 11 pattern pattern NN cord-267475-6f4h3cck 17 12 of of IN cord-267475-6f4h3cck 17 13 transcription transcription NN cord-267475-6f4h3cck 17 14 – – : cord-267475-6f4h3cck 17 15 forcing force VBG cord-267475-6f4h3cck 17 16 production production NN cord-267475-6f4h3cck 17 17 of of IN cord-267475-6f4h3cck 17 18 monocistronic monocistronic NNP cord-267475-6f4h3cck 17 19 mRNAs mrnas XX cord-267475-6f4h3cck 17 20 – – : cord-267475-6f4h3cck 17 21 and and CC cord-267475-6f4h3cck 17 22 the the DT cord-267475-6f4h3cck 17 23 pattern pattern NN cord-267475-6f4h3cck 17 24 of of IN cord-267475-6f4h3cck 17 25 translation translation NN cord-267475-6f4h3cck 17 26 of of IN cord-267475-6f4h3cck 17 27 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 17 28 cellular cellular JJ cord-267475-6f4h3cck 17 29 and and CC cord-267475-6f4h3cck 17 30 viral viral JJ cord-267475-6f4h3cck 17 31 genes gene NNS cord-267475-6f4h3cck 17 32 . . . cord-267475-6f4h3cck 18 1 The the DT cord-267475-6f4h3cck 18 2 scanning scanning NN cord-267475-6f4h3cck 18 3 mechanism mechanism NN cord-267475-6f4h3cck 18 4 for for IN cord-267475-6f4h3cck 18 5 initiation initiation NN cord-267475-6f4h3cck 18 6 of of IN cord-267475-6f4h3cck 18 7 translation translation NN cord-267475-6f4h3cck 18 8 postulates postulate VBZ cord-267475-6f4h3cck 18 9 that that IN cord-267475-6f4h3cck 18 10 the the DT cord-267475-6f4h3cck 18 11 small small JJ cord-267475-6f4h3cck 18 12 ( ( -LRB- cord-267475-6f4h3cck 18 13 40S 40s CD cord-267475-6f4h3cck 18 14 ) ) -RRB- cord-267475-6f4h3cck 18 15 ribosomal ribosomal JJ cord-267475-6f4h3cck 18 16 subunit subunit NN cord-267475-6f4h3cck 18 17 enters enter VBZ cord-267475-6f4h3cck 18 18 at at IN cord-267475-6f4h3cck 18 19 the the DT cord-267475-6f4h3cck 18 20 5 5 CD cord-267475-6f4h3cck 18 21 0 0 CD cord-267475-6f4h3cck 18 22 end end NN cord-267475-6f4h3cck 18 23 of of IN cord-267475-6f4h3cck 18 24 the the DT cord-267475-6f4h3cck 18 25 mRNA mrna NN cord-267475-6f4h3cck 18 26 and and CC cord-267475-6f4h3cck 18 27 migrates migrate VBZ cord-267475-6f4h3cck 18 28 linearly linearly RB cord-267475-6f4h3cck 18 29 , , , cord-267475-6f4h3cck 18 30 stopping stop VBG cord-267475-6f4h3cck 18 31 when when WRB cord-267475-6f4h3cck 18 32 the the DT cord-267475-6f4h3cck 18 33 first first JJ cord-267475-6f4h3cck 18 34 AUG AUG NNP cord-267475-6f4h3cck 18 35 codon codon NN cord-267475-6f4h3cck 18 36 is be VBZ cord-267475-6f4h3cck 18 37 reached reach VBN cord-267475-6f4h3cck 18 38 . . . cord-267475-6f4h3cck 19 1 Consistent consistent JJ cord-267475-6f4h3cck 19 2 with with IN cord-267475-6f4h3cck 19 3 the the DT cord-267475-6f4h3cck 19 4 postulated postulate VBN cord-267475-6f4h3cck 19 5 5 5 CD cord-267475-6f4h3cck 19 6 0 0 CD cord-267475-6f4h3cck 19 7 end end NN cord-267475-6f4h3cck 19 8 - - HYPH cord-267475-6f4h3cck 19 9 dependent dependent JJ cord-267475-6f4h3cck 19 10 entry entry NN cord-267475-6f4h3cck 19 11 of of IN cord-267475-6f4h3cck 19 12 ribosomes ribosome NNS cord-267475-6f4h3cck 19 13 , , , cord-267475-6f4h3cck 19 14 translation translation NN cord-267475-6f4h3cck 19 15 in in IN cord-267475-6f4h3cck 19 16 vivo vivo NN cord-267475-6f4h3cck 19 17 is be VBZ cord-267475-6f4h3cck 19 18 strongly strongly RB cord-267475-6f4h3cck 19 19 augmented augment VBN cord-267475-6f4h3cck 19 20 by by IN cord-267475-6f4h3cck 19 21 the the DT cord-267475-6f4h3cck 19 22 m7 m7 NN cord-267475-6f4h3cck 19 23 G g NN cord-267475-6f4h3cck 19 24 cap cap NN cord-267475-6f4h3cck 19 25 ( ( -LRB- cord-267475-6f4h3cck 19 26 Furuichi Furuichi NNP cord-267475-6f4h3cck 19 27 and and CC cord-267475-6f4h3cck 19 28 Shatkin Shatkin NNP cord-267475-6f4h3cck 19 29 , , , cord-267475-6f4h3cck 19 30 2000 2000 CD cord-267475-6f4h3cck 19 31 ; ; : cord-267475-6f4h3cck 19 32 Horikami Horikami NNP cord-267475-6f4h3cck 19 33 et et NNP cord-267475-6f4h3cck 19 34 al al NNP cord-267475-6f4h3cck 19 35 . . NNP cord-267475-6f4h3cck 19 36 , , , cord-267475-6f4h3cck 19 37 1984 1984 CD cord-267475-6f4h3cck 19 38 ; ; : cord-267475-6f4h3cck 19 39 Lo Lo NNP cord-267475-6f4h3cck 19 40 et et NNP cord-267475-6f4h3cck 19 41 al al NNP cord-267475-6f4h3cck 19 42 . . NNP cord-267475-6f4h3cck 19 43 , , , cord-267475-6f4h3cck 19 44 1998 1998 CD cord-267475-6f4h3cck 19 45 ; ; : cord-267475-6f4h3cck 19 46 Neeleman Neeleman NNP cord-267475-6f4h3cck 19 47 et et NNP cord-267475-6f4h3cck 19 48 al al NNP cord-267475-6f4h3cck 19 49 . . NNP cord-267475-6f4h3cck 19 50 , , , cord-267475-6f4h3cck 19 51 2001 2001 CD cord-267475-6f4h3cck 19 52 ) ) -RRB- cord-267475-6f4h3cck 19 53 and and CC cord-267475-6f4h3cck 19 54 ribosome ribosome NN cord-267475-6f4h3cck 19 55 binding binding NN cord-267475-6f4h3cck 19 56 in in IN cord-267475-6f4h3cck 19 57 vitro vitro FW cord-267475-6f4h3cck 19 58 is be VBZ cord-267475-6f4h3cck 19 59 prevented prevent VBN cord-267475-6f4h3cck 19 60 by by IN cord-267475-6f4h3cck 19 61 circularization circularization NN cord-267475-6f4h3cck 19 62 of of IN cord-267475-6f4h3cck 19 63 the the DT cord-267475-6f4h3cck 19 64 mRNA mrna NN cord-267475-6f4h3cck 19 65 ( ( -LRB- cord-267475-6f4h3cck 19 66 Kozak Kozak NNP cord-267475-6f4h3cck 19 67 , , , cord-267475-6f4h3cck 19 68 1979a 1979a CD cord-267475-6f4h3cck 19 69 ; ; : cord-267475-6f4h3cck 19 70 Konarska Konarska NNP cord-267475-6f4h3cck 19 71 et et NNP cord-267475-6f4h3cck 19 72 al al NNP cord-267475-6f4h3cck 19 73 . . NNP cord-267475-6f4h3cck 19 74 , , , cord-267475-6f4h3cck 19 75 1981 1981 CD cord-267475-6f4h3cck 19 76 ) ) -RRB- cord-267475-6f4h3cck 19 77 . . . cord-267475-6f4h3cck 20 1 Perhaps perhaps RB cord-267475-6f4h3cck 20 2 because because IN cord-267475-6f4h3cck 20 3 the the DT cord-267475-6f4h3cck 20 4 scanning scanning NN cord-267475-6f4h3cck 20 5 mechanism mechanism NN cord-267475-6f4h3cck 20 6 has have VBZ cord-267475-6f4h3cck 20 7 been be VBN cord-267475-6f4h3cck 20 8 around around RB cord-267475-6f4h3cck 20 9 for for IN cord-267475-6f4h3cck 20 10 a a DT cord-267475-6f4h3cck 20 11 while while NN cord-267475-6f4h3cck 20 12 , , , cord-267475-6f4h3cck 20 13 the the DT cord-267475-6f4h3cck 20 14 evidence evidence NN cord-267475-6f4h3cck 20 15 for for IN cord-267475-6f4h3cck 20 16 some some DT cord-267475-6f4h3cck 20 17 basic basic JJ cord-267475-6f4h3cck 20 18 points point NNS cord-267475-6f4h3cck 20 19 has have VBZ cord-267475-6f4h3cck 20 20 been be VBN cord-267475-6f4h3cck 20 21 forgotten forget VBN cord-267475-6f4h3cck 20 22 . . . cord-267475-6f4h3cck 21 1 One one CD cord-267475-6f4h3cck 21 2 recent recent JJ cord-267475-6f4h3cck 21 3 commentary commentary NN cord-267475-6f4h3cck 21 4 even even RB cord-267475-6f4h3cck 21 5 questions question NNS cord-267475-6f4h3cck 21 6 whether whether IN cord-267475-6f4h3cck 21 7 the the DT cord-267475-6f4h3cck 21 8 40S 40s CD cord-267475-6f4h3cck 21 9 ribosomal ribosomal JJ cord-267475-6f4h3cck 21 10 subunit subunit NN cord-267475-6f4h3cck 21 11 has have VBZ cord-267475-6f4h3cck 21 12 anything anything NN cord-267475-6f4h3cck 21 13 to to TO cord-267475-6f4h3cck 21 14 do do VB cord-267475-6f4h3cck 21 15 with with IN cord-267475-6f4h3cck 21 16 it -PRON- PRP cord-267475-6f4h3cck 21 17 ( ( -LRB- cord-267475-6f4h3cck 21 18 Mathews Mathews NNP cord-267475-6f4h3cck 21 19 , , , cord-267475-6f4h3cck 21 20 2002 2002 CD cord-267475-6f4h3cck 21 21 ) ) -RRB- cord-267475-6f4h3cck 21 22 . . . cord-267475-6f4h3cck 22 1 The the DT cord-267475-6f4h3cck 22 2 easiest easy JJS cord-267475-6f4h3cck 22 3 answer answer NN cord-267475-6f4h3cck 22 4 is be VBZ cord-267475-6f4h3cck 22 5 that that IN cord-267475-6f4h3cck 22 6 the the DT cord-267475-6f4h3cck 22 7 stopscanning stopscanne VBG cord-267475-6f4h3cck 22 8 step step NN cord-267475-6f4h3cck 22 9 is be VBZ cord-267475-6f4h3cck 22 10 clearly clearly RB cord-267475-6f4h3cck 22 11 mediated mediate VBN cord-267475-6f4h3cck 22 12 by by IN cord-267475-6f4h3cck 22 13 pairing pair VBG cord-267475-6f4h3cck 22 14 of of IN cord-267475-6f4h3cck 22 15 the the DT cord-267475-6f4h3cck 22 16 initiation initiation NN cord-267475-6f4h3cck 22 17 codon codon NN cord-267475-6f4h3cck 22 18 with with IN cord-267475-6f4h3cck 22 19 the the DT cord-267475-6f4h3cck 22 20 anticodon anticodon NN cord-267475-6f4h3cck 22 21 in in IN cord-267475-6f4h3cck 23 1 Met Met NNP cord-267475-6f4h3cck 23 2 - - HYPH cord-267475-6f4h3cck 23 3 tRNA tRNA NNP cord-267475-6f4h3cck 23 4 i i PRP cord-267475-6f4h3cck 24 1 ( ( -LRB- cord-267475-6f4h3cck 24 2 Cigan Cigan NNP cord-267475-6f4h3cck 24 3 et et FW cord-267475-6f4h3cck 24 4 al al NNP cord-267475-6f4h3cck 24 5 . . . cord-267475-6f4h3cck 25 1 , , , cord-267475-6f4h3cck 25 2 1988a 1988a CD cord-267475-6f4h3cck 25 3 ) ) -RRB- cord-267475-6f4h3cck 25 4 , , , cord-267475-6f4h3cck 25 5 and and CC cord-267475-6f4h3cck 25 6 the the DT cord-267475-6f4h3cck 25 7 40S 40s CD cord-267475-6f4h3cck 25 8 ribosomal ribosomal JJ cord-267475-6f4h3cck 25 9 subunit subunit NN cord-267475-6f4h3cck 25 10 is be VBZ cord-267475-6f4h3cck 25 11 the the DT cord-267475-6f4h3cck 25 12 carrier carrier NN cord-267475-6f4h3cck 25 13 of of IN cord-267475-6f4h3cck 25 14 Met Met NNP cord-267475-6f4h3cck 25 15 - - HYPH cord-267475-6f4h3cck 25 16 tRNA tRNA NNP cord-267475-6f4h3cck 25 17 i i NNP cord-267475-6f4h3cck 25 18 · · NFP cord-267475-6f4h3cck 25 19 eIF2 eIF2 NNP cord-267475-6f4h3cck 25 20 . . . cord-267475-6f4h3cck 26 1 But but CC cord-267475-6f4h3cck 26 2 the the DT cord-267475-6f4h3cck 26 3 40S 40s CD cord-267475-6f4h3cck 26 4 subunit subunit NN cord-267475-6f4h3cck 26 5 was be VBD cord-267475-6f4h3cck 26 6 already already RB cord-267475-6f4h3cck 26 7 implicated implicate VBN cord-267475-6f4h3cck 26 8 by by IN cord-267475-6f4h3cck 26 9 experiments experiment NNS cord-267475-6f4h3cck 26 10 done do VBN cord-267475-6f4h3cck 26 11 earlier early RBR cord-267475-6f4h3cck 26 12 . . . cord-267475-6f4h3cck 27 1 The the DT cord-267475-6f4h3cck 27 2 experiments experiment NNS cord-267475-6f4h3cck 27 3 that that WDT cord-267475-6f4h3cck 27 4 gave give VBD cord-267475-6f4h3cck 27 5 rise rise NN cord-267475-6f4h3cck 27 6 to to IN cord-267475-6f4h3cck 27 7 the the DT cord-267475-6f4h3cck 27 8 scanning scanning NN cord-267475-6f4h3cck 27 9 model model NN cord-267475-6f4h3cck 27 10 concerned concern VBD cord-267475-6f4h3cck 27 11 unusual unusual JJ cord-267475-6f4h3cck 27 12 polysome polysome NN cord-267475-6f4h3cck 27 13 - - HYPH cord-267475-6f4h3cck 27 14 like like JJ cord-267475-6f4h3cck 27 15 complexes complex NNS cord-267475-6f4h3cck 27 16 formed form VBN cord-267475-6f4h3cck 27 17 in in IN cord-267475-6f4h3cck 27 18 the the DT cord-267475-6f4h3cck 27 19 presence presence NN cord-267475-6f4h3cck 27 20 of of IN cord-267475-6f4h3cck 27 21 edeine edeine NNP cord-267475-6f4h3cck 27 22 , , , cord-267475-6f4h3cck 27 23 an an DT cord-267475-6f4h3cck 27 24 antibiotic antibiotic NN cord-267475-6f4h3cck 27 25 which which WDT cord-267475-6f4h3cck 27 26 blocks block VBZ cord-267475-6f4h3cck 27 27 recognition recognition NN cord-267475-6f4h3cck 27 28 of of IN cord-267475-6f4h3cck 27 29 the the DT cord-267475-6f4h3cck 27 30 AUG AUG NNP cord-267475-6f4h3cck 27 31 codon codon NN cord-267475-6f4h3cck 27 32 ( ( -LRB- cord-267475-6f4h3cck 27 33 Kozak Kozak NNP cord-267475-6f4h3cck 27 34 and and CC cord-267475-6f4h3cck 27 35 Shatkin Shatkin NNP cord-267475-6f4h3cck 27 36 , , , cord-267475-6f4h3cck 27 37 1978 1978 CD cord-267475-6f4h3cck 27 38 ) ) -RRB- cord-267475-6f4h3cck 27 39 . . . cord-267475-6f4h3cck 28 1 Analysis analysis NN cord-267475-6f4h3cck 28 2 of of IN cord-267475-6f4h3cck 28 3 the the DT cord-267475-6f4h3cck 28 4 rapidly rapidly RB cord-267475-6f4h3cck 28 5 sedimenting sediment VBG cord-267475-6f4h3cck 28 6 complexes complex NNS cord-267475-6f4h3cck 28 7 revealed reveal VBD cord-267475-6f4h3cck 28 8 40S 40s CD cord-267475-6f4h3cck 28 9 ribosomal ribosomal JJ cord-267475-6f4h3cck 28 10 subunits subunit NNS cord-267475-6f4h3cck 28 11 distributed distribute VBN cord-267475-6f4h3cck 28 12 throughout throughout IN cord-267475-6f4h3cck 28 13 the the DT cord-267475-6f4h3cck 28 14 body body NN cord-267475-6f4h3cck 28 15 of of IN cord-267475-6f4h3cck 28 16 the the DT cord-267475-6f4h3cck 28 17 mRNA mrna NN cord-267475-6f4h3cck 28 18 . . . cord-267475-6f4h3cck 29 1 Because because IN cord-267475-6f4h3cck 29 2 control control NN cord-267475-6f4h3cck 29 3 experiments experiment NNS cord-267475-6f4h3cck 29 4 showed show VBD cord-267475-6f4h3cck 29 5 that that IN cord-267475-6f4h3cck 29 6 , , , cord-267475-6f4h3cck 29 7 even even RB cord-267475-6f4h3cck 29 8 in in IN cord-267475-6f4h3cck 29 9 the the DT cord-267475-6f4h3cck 29 10 presence presence NN cord-267475-6f4h3cck 29 11 of of IN cord-267475-6f4h3cck 29 12 edeine edeine NN cord-267475-6f4h3cck 29 13 , , , cord-267475-6f4h3cck 29 14 ribosomes ribosome NNS cord-267475-6f4h3cck 29 15 can can MD cord-267475-6f4h3cck 29 16 enter enter VB cord-267475-6f4h3cck 29 17 only only RB cord-267475-6f4h3cck 29 18 from from IN cord-267475-6f4h3cck 29 19 the the DT cord-267475-6f4h3cck 29 20 5 5 CD cord-267475-6f4h3cck 29 21 0 0 CD cord-267475-6f4h3cck 29 22 end end NN cord-267475-6f4h3cck 29 23 , , , cord-267475-6f4h3cck 29 24 the the DT cord-267475-6f4h3cck 29 25 simplest simple JJS cord-267475-6f4h3cck 29 26 explanation explanation NN cord-267475-6f4h3cck 29 27 was be VBD cord-267475-6f4h3cck 29 28 that that IN cord-267475-6f4h3cck 29 29 40S 40s CD cord-267475-6f4h3cck 29 30 subunits subunit NNS cord-267475-6f4h3cck 29 31 enter enter VBP cord-267475-6f4h3cck 29 32 at at IN cord-267475-6f4h3cck 29 33 the the DT cord-267475-6f4h3cck 29 34 5 5 CD cord-267475-6f4h3cck 29 35 0 0 CD cord-267475-6f4h3cck 29 36 end end NN cord-267475-6f4h3cck 29 37 and and CC cord-267475-6f4h3cck 29 38 then then RB cord-267475-6f4h3cck 29 39 migrate migrate VB cord-267475-6f4h3cck 29 40 into into IN cord-267475-6f4h3cck 29 41 the the DT cord-267475-6f4h3cck 29 42 interior interior NN cord-267475-6f4h3cck 29 43 of of IN cord-267475-6f4h3cck 29 44 the the DT cord-267475-6f4h3cck 29 45 mRNA mRNA NNP cord-267475-6f4h3cck 29 46 ; ; : cord-267475-6f4h3cck 29 47 in in IN cord-267475-6f4h3cck 29 48 the the DT cord-267475-6f4h3cck 29 49 absence absence NN cord-267475-6f4h3cck 29 50 of of IN cord-267475-6f4h3cck 29 51 edeine edeine NN cord-267475-6f4h3cck 29 52 , , , cord-267475-6f4h3cck 29 53 the the DT cord-267475-6f4h3cck 29 54 migration migration NN cord-267475-6f4h3cck 29 55 would would MD cord-267475-6f4h3cck 29 56 stop stop VB cord-267475-6f4h3cck 29 57 when when WRB cord-267475-6f4h3cck 29 58 an an DT cord-267475-6f4h3cck 29 59 AUG AUG NNP cord-267475-6f4h3cck 29 60 codon codon NN cord-267475-6f4h3cck 29 61 is be VBZ cord-267475-6f4h3cck 29 62 reached reach VBN cord-267475-6f4h3cck 29 63 . . . cord-267475-6f4h3cck 30 1 Independent independent JJ cord-267475-6f4h3cck 30 2 experiments experiment NNS cord-267475-6f4h3cck 30 3 confirmed confirm VBD cord-267475-6f4h3cck 30 4 that that IN cord-267475-6f4h3cck 30 5 edeine edeine NN cord-267475-6f4h3cck 30 6 is be VBZ cord-267475-6f4h3cck 30 7 targeted target VBN cord-267475-6f4h3cck 30 8 to to IN cord-267475-6f4h3cck 30 9 the the DT cord-267475-6f4h3cck 30 10 ribosome ribosome NN cord-267475-6f4h3cck 30 11 ( ( -LRB- cord-267475-6f4h3cck 30 12 Herrera Herrera NNP cord-267475-6f4h3cck 30 13 et et NNP cord-267475-6f4h3cck 30 14 al al NNP cord-267475-6f4h3cck 30 15 . . NNP cord-267475-6f4h3cck 30 16 , , , cord-267475-6f4h3cck 30 17 1986 1986 CD cord-267475-6f4h3cck 30 18 ) ) -RRB- cord-267475-6f4h3cck 30 19 , , , cord-267475-6f4h3cck 30 20 and and CC cord-267475-6f4h3cck 30 21 use use NN cord-267475-6f4h3cck 30 22 of of IN cord-267475-6f4h3cck 30 23 a a DT cord-267475-6f4h3cck 30 24 fractionated fractionate VBN cord-267475-6f4h3cck 30 25 translation translation NN cord-267475-6f4h3cck 30 26 system system NN cord-267475-6f4h3cck 30 27 confirmed confirm VBD cord-267475-6f4h3cck 30 28 that that IN cord-267475-6f4h3cck 30 29 the the DT cord-267475-6f4h3cck 30 30 edeine edeine NN cord-267475-6f4h3cck 30 31 - - HYPH cord-267475-6f4h3cck 30 32 induced induce VBN cord-267475-6f4h3cck 30 33 complexes complex NNS cord-267475-6f4h3cck 30 34 are be VBP cord-267475-6f4h3cck 30 35 formed form VBN cord-267475-6f4h3cck 30 36 by by IN cord-267475-6f4h3cck 30 37 40S 40s CD cord-267475-6f4h3cck 30 38 but but CC cord-267475-6f4h3cck 30 39 not not RB cord-267475-6f4h3cck 30 40 60S 60s CD cord-267475-6f4h3cck 30 41 ribosomal ribosomal JJ cord-267475-6f4h3cck 30 42 subunits subunit NNS cord-267475-6f4h3cck 30 43 ( ( -LRB- cord-267475-6f4h3cck 30 44 Kozak Kozak NNP cord-267475-6f4h3cck 30 45 and and CC cord-267475-6f4h3cck 30 46 Shatkin Shatkin NNP cord-267475-6f4h3cck 30 47 , , , cord-267475-6f4h3cck 30 48 1978 1978 CD cord-267475-6f4h3cck 30 49 ; ; : cord-267475-6f4h3cck 30 50 Kozak Kozak NNP cord-267475-6f4h3cck 30 51 , , , cord-267475-6f4h3cck 30 52 1979b 1979b CD cord-267475-6f4h3cck 30 53 ) ) -RRB- cord-267475-6f4h3cck 30 54 . . . cord-267475-6f4h3cck 31 1 Subsequent subsequent JJ cord-267475-6f4h3cck 31 2 experiments experiment NNS cord-267475-6f4h3cck 31 3 , , , cord-267475-6f4h3cck 31 4 with with IN cord-267475-6f4h3cck 31 5 edeine edeine NN cord-267475-6f4h3cck 31 6 omitted omit VBN cord-267475-6f4h3cck 31 7 , , , cord-267475-6f4h3cck 31 8 showed show VBD cord-267475-6f4h3cck 31 9 that that IN cord-267475-6f4h3cck 31 10 scanning scanning NN cord-267475-6f4h3cck 31 11 can can MD cord-267475-6f4h3cck 31 12 be be VB cord-267475-6f4h3cck 31 13 interrupted interrupt VBN cord-267475-6f4h3cck 31 14 by by IN cord-267475-6f4h3cck 31 15 inserting insert VBG cord-267475-6f4h3cck 31 16 a a DT cord-267475-6f4h3cck 31 17 base base NN cord-267475-6f4h3cck 31 18 - - HYPH cord-267475-6f4h3cck 31 19 paired pair VBN cord-267475-6f4h3cck 31 20 structure structure NN cord-267475-6f4h3cck 31 21 between between IN cord-267475-6f4h3cck 31 22 the the DT cord-267475-6f4h3cck 31 23 cap cap NN cord-267475-6f4h3cck 31 24 and and CC cord-267475-6f4h3cck 31 25 the the DT cord-267475-6f4h3cck 31 26 AUG AUG NNP cord-267475-6f4h3cck 31 27 codon codon NN cord-267475-6f4h3cck 31 28 ; ; : cord-267475-6f4h3cck 31 29 the the DT cord-267475-6f4h3cck 31 30 resulting result VBG cord-267475-6f4h3cck 31 31 abortive abortive JJ cord-267475-6f4h3cck 31 32 complexes complex NNS cord-267475-6f4h3cck 31 33 sediment sediment NN cord-267475-6f4h3cck 31 34 around around RB cord-267475-6f4h3cck 31 35 40S 40s CD cord-267475-6f4h3cck 31 36 ( ( -LRB- cord-267475-6f4h3cck 31 37 Kozak Kozak NNP cord-267475-6f4h3cck 31 38 , , , cord-267475-6f4h3cck 31 39 1989 1989 CD cord-267475-6f4h3cck 31 40 ( ( -LRB- cord-267475-6f4h3cck 31 41 Kozak Kozak NNP cord-267475-6f4h3cck 31 42 , , , cord-267475-6f4h3cck 31 43 , , , cord-267475-6f4h3cck 31 44 1998 1998 CD cord-267475-6f4h3cck 32 1 Paraskeva Paraskeva NNP cord-267475-6f4h3cck 32 2 et et NNP cord-267475-6f4h3cck 32 3 al al NNP cord-267475-6f4h3cck 32 4 . . NNP cord-267475-6f4h3cck 32 5 , , , cord-267475-6f4h3cck 32 6 1999 1999 CD cord-267475-6f4h3cck 32 7 ) ) -RRB- cord-267475-6f4h3cck 32 8 . . . cord-267475-6f4h3cck 33 1 We -PRON- PRP cord-267475-6f4h3cck 33 2 are be VBP cord-267475-6f4h3cck 33 3 not not RB cord-267475-6f4h3cck 33 4 yet yet RB cord-267475-6f4h3cck 33 5 sure sure JJ cord-267475-6f4h3cck 33 6 which which WDT cord-267475-6f4h3cck 33 7 initiation initiation NN cord-267475-6f4h3cck 33 8 factors factor NNS cord-267475-6f4h3cck 33 9 are be VBP cord-267475-6f4h3cck 33 10 associated associate VBN cord-267475-6f4h3cck 33 11 with with IN cord-267475-6f4h3cck 33 12 the the DT cord-267475-6f4h3cck 33 13 40S 40s CD cord-267475-6f4h3cck 33 14 ribosomal ribosomal JJ cord-267475-6f4h3cck 33 15 subunit subunit NN cord-267475-6f4h3cck 33 16 during during IN cord-267475-6f4h3cck 33 17 the the DT cord-267475-6f4h3cck 33 18 scanning scanning NN cord-267475-6f4h3cck 33 19 phase phase NN cord-267475-6f4h3cck 33 20 . . . cord-267475-6f4h3cck 34 1 The the DT cord-267475-6f4h3cck 34 2 only only JJ cord-267475-6f4h3cck 34 3 factors factor NNS cord-267475-6f4h3cck 34 4 whose whose WP$ cord-267475-6f4h3cck 34 5 role role NN cord-267475-6f4h3cck 34 6 in in IN cord-267475-6f4h3cck 34 7 scanning scanning NN cord-267475-6f4h3cck 34 8 has have VBZ cord-267475-6f4h3cck 34 9 been be VBN cord-267475-6f4h3cck 34 10 defined define VBN cord-267475-6f4h3cck 34 11 clearly clearly RB cord-267475-6f4h3cck 34 12 are be VBP cord-267475-6f4h3cck 34 13 the the DT cord-267475-6f4h3cck 34 14 GTP gtp NN cord-267475-6f4h3cck 34 15 - - HYPH cord-267475-6f4h3cck 34 16 binding bind VBG cord-267475-6f4h3cck 34 17 protein protein NN cord-267475-6f4h3cck 34 18 eIF2 eIF2 NNP cord-267475-6f4h3cck 34 19 , , , cord-267475-6f4h3cck 34 20 which which WDT cord-267475-6f4h3cck 34 21 escorts escort NNS cord-267475-6f4h3cck 34 22 Met Met NNP cord-267475-6f4h3cck 34 23 - - HYPH cord-267475-6f4h3cck 34 24 tRNA tRNA NNP cord-267475-6f4h3cck 35 1 i i PRP cord-267475-6f4h3cck 35 2 onto onto IN cord-267475-6f4h3cck 35 3 the the DT cord-267475-6f4h3cck 35 4 40S 40s CD cord-267475-6f4h3cck 35 5 subunit subunit NN cord-267475-6f4h3cck 35 6 , , , cord-267475-6f4h3cck 35 7 and and CC cord-267475-6f4h3cck 35 8 eIF5 eIF5 NNP cord-267475-6f4h3cck 35 9 , , , cord-267475-6f4h3cck 35 10 which which WDT cord-267475-6f4h3cck 35 11 activates activate VBZ cord-267475-6f4h3cck 35 12 GTP GTP NNP cord-267475-6f4h3cck 35 13 hydrolysis hydrolysis NN cord-267475-6f4h3cck 35 14 by by IN cord-267475-6f4h3cck 36 1 eIF2 eIF2 NNP cord-267475-6f4h3cck 36 2 ( ( -LRB- cord-267475-6f4h3cck 36 3 Asano Asano NNP cord-267475-6f4h3cck 36 4 et et NNP cord-267475-6f4h3cck 36 5 al al NNP cord-267475-6f4h3cck 36 6 . . NNP cord-267475-6f4h3cck 36 7 , , , cord-267475-6f4h3cck 36 8 2001 2001 CD cord-267475-6f4h3cck 36 9 ; ; : cord-267475-6f4h3cck 36 10 Das Das NNP cord-267475-6f4h3cck 36 11 et et FW cord-267475-6f4h3cck 36 12 al al NNP cord-267475-6f4h3cck 36 13 . . NNP cord-267475-6f4h3cck 36 14 , , , cord-267475-6f4h3cck 36 15 2001 2001 CD cord-267475-6f4h3cck 36 16 ) ) -RRB- cord-267475-6f4h3cck 36 17 . . . cord-267475-6f4h3cck 37 1 By by IN cord-267475-6f4h3cck 37 2 controlling control VBG cord-267475-6f4h3cck 37 3 the the DT cord-267475-6f4h3cck 37 4 rate rate NN cord-267475-6f4h3cck 37 5 of of IN cord-267475-6f4h3cck 37 6 GTP gtp NN cord-267475-6f4h3cck 37 7 hydrolysis hydrolysis NN cord-267475-6f4h3cck 37 8 , , , cord-267475-6f4h3cck 37 9 eIF5 eIF5 NNP cord-267475-6f4h3cck 37 10 controls control VBZ cord-267475-6f4h3cck 37 11 the the DT cord-267475-6f4h3cck 37 12 fidelity fidelity NN cord-267475-6f4h3cck 37 13 of of IN cord-267475-6f4h3cck 37 14 initiation initiation NN cord-267475-6f4h3cck 37 15 , , , cord-267475-6f4h3cck 37 16 i.e. i.e. FW cord-267475-6f4h3cck 37 17 the the DT cord-267475-6f4h3cck 37 18 fidelity fidelity NN cord-267475-6f4h3cck 37 19 of of IN cord-267475-6f4h3cck 37 20 the the DT cord-267475-6f4h3cck 37 21 stop stop VB cord-267475-6f4h3cck 37 22 - - HYPH cord-267475-6f4h3cck 37 23 scanning scanning NN cord-267475-6f4h3cck 37 24 step step NN cord-267475-6f4h3cck 37 25 . . . cord-267475-6f4h3cck 38 1 Other other JJ cord-267475-6f4h3cck 38 2 protein protein NN cord-267475-6f4h3cck 38 3 factors factor NNS cord-267475-6f4h3cck 38 4 have have VBP cord-267475-6f4h3cck 38 5 not not RB cord-267475-6f4h3cck 38 6 yet yet RB cord-267475-6f4h3cck 38 7 been be VBN cord-267475-6f4h3cck 38 8 fitted fit VBN cord-267475-6f4h3cck 38 9 in in IN cord-267475-6f4h3cck 38 10 . . . cord-267475-6f4h3cck 39 1 ( ( -LRB- cord-267475-6f4h3cck 39 2 The the DT cord-267475-6f4h3cck 39 3 voluminous voluminous JJ cord-267475-6f4h3cck 39 4 literature literature NN cord-267475-6f4h3cck 39 5 on on IN cord-267475-6f4h3cck 39 6 factors factor NNS cord-267475-6f4h3cck 39 7 focuses focus VBZ cord-267475-6f4h3cck 39 8 on on IN cord-267475-6f4h3cck 39 9 modifications modification NNS cord-267475-6f4h3cck 39 10 -phosphorylation -phosphorylation JJS cord-267475-6f4h3cck 39 11 , , , cord-267475-6f4h3cck 39 12 cleavages cleavage NNS cord-267475-6f4h3cck 39 13 -rather -rather : cord-267475-6f4h3cck 39 14 than than IN cord-267475-6f4h3cck 39 15 on on IN cord-267475-6f4h3cck 39 16 defining define VBG cord-267475-6f4h3cck 39 17 the the DT cord-267475-6f4h3cck 39 18 initiation initiation NN cord-267475-6f4h3cck 39 19 pathway pathway NN cord-267475-6f4h3cck 39 20 . . . cord-267475-6f4h3cck 40 1 Basic basic JJ cord-267475-6f4h3cck 40 2 questions question NNS cord-267475-6f4h3cck 40 3 , , , cord-267475-6f4h3cck 40 4 such such JJ cord-267475-6f4h3cck 40 5 as as IN cord-267475-6f4h3cck 40 6 when when WRB cord-267475-6f4h3cck 40 7 each each DT cord-267475-6f4h3cck 40 8 factor factor NN cord-267475-6f4h3cck 40 9 enters enter VBZ cord-267475-6f4h3cck 40 10 and and CC cord-267475-6f4h3cck 40 11 leaves leave NNS cord-267475-6f4h3cck 40 12 , , , cord-267475-6f4h3cck 40 13 have have VBP cord-267475-6f4h3cck 40 14 not not RB cord-267475-6f4h3cck 40 15 yet yet RB cord-267475-6f4h3cck 40 16 been be VBN cord-267475-6f4h3cck 40 17 answered answer VBN cord-267475-6f4h3cck 40 18 . . . cord-267475-6f4h3cck 40 19 ) ) -RRB- cord-267475-6f4h3cck 41 1 One one CD cord-267475-6f4h3cck 41 2 untested untested JJ cord-267475-6f4h3cck 41 3 possibility possibility NN cord-267475-6f4h3cck 41 4 is be VBZ cord-267475-6f4h3cck 41 5 that that IN cord-267475-6f4h3cck 41 6 the the DT cord-267475-6f4h3cck 41 7 large large JJ cord-267475-6f4h3cck 41 8 initiation initiation NN cord-267475-6f4h3cck 41 9 factor factor NN cord-267475-6f4h3cck 41 10 eIF3 eIF3 NNP cord-267475-6f4h3cck 41 11 , , , cord-267475-6f4h3cck 41 12 bound bind VBN cord-267475-6f4h3cck 41 13 to to IN cord-267475-6f4h3cck 41 14 the the DT cord-267475-6f4h3cck 41 15 40S 40s CD cord-267475-6f4h3cck 41 16 ribosomal ribosomal JJ cord-267475-6f4h3cck 41 17 subunit subunit NN cord-267475-6f4h3cck 41 18 , , , cord-267475-6f4h3cck 41 19 might may MD cord-267475-6f4h3cck 41 20 form form VB cord-267475-6f4h3cck 41 21 a a DT cord-267475-6f4h3cck 41 22 clamp clamp NN cord-267475-6f4h3cck 41 23 around around IN cord-267475-6f4h3cck 41 24 the the DT cord-267475-6f4h3cck 41 25 mRNA mrna NN cord-267475-6f4h3cck 41 26 that that WDT cord-267475-6f4h3cck 41 27 is be VBZ cord-267475-6f4h3cck 41 28 opened open VBN cord-267475-6f4h3cck 41 29 and and CC cord-267475-6f4h3cck 41 30 closed close VBN cord-267475-6f4h3cck 41 31 by by IN cord-267475-6f4h3cck 41 32 cycles cycle NNS cord-267475-6f4h3cck 41 33 of of IN cord-267475-6f4h3cck 41 34 ATP ATP NNP cord-267475-6f4h3cck 41 35 hydrolysis hydrolysis NN cord-267475-6f4h3cck 41 36 . . . cord-267475-6f4h3cck 42 1 Scanning scanning NN cord-267475-6f4h3cck 42 2 appears appear VBZ cord-267475-6f4h3cck 42 3 to to TO cord-267475-6f4h3cck 42 4 be be VB cord-267475-6f4h3cck 42 5 dependent dependent JJ cord-267475-6f4h3cck 42 6 on on IN cord-267475-6f4h3cck 42 7 ATP ATP NNP cord-267475-6f4h3cck 42 8 hydrolysis hydrolysis NN cord-267475-6f4h3cck 42 9 ( ( -LRB- cord-267475-6f4h3cck 42 10 Kozak Kozak NNP cord-267475-6f4h3cck 42 11 , , , cord-267475-6f4h3cck 42 12 1980 1980 CD cord-267475-6f4h3cck 42 13 ) ) -RRB- cord-267475-6f4h3cck 42 14 , , , cord-267475-6f4h3cck 42 15 thereby thereby RB cord-267475-6f4h3cck 42 16 implicating implicate VBG cord-267475-6f4h3cck 42 17 eIF4A eIF4A NNS cord-267475-6f4h3cck 42 18 , , , cord-267475-6f4h3cck 42 19 an an DT cord-267475-6f4h3cck 42 20 RNA rna NN cord-267475-6f4h3cck 42 21 - - HYPH cord-267475-6f4h3cck 42 22 dependent dependent JJ cord-267475-6f4h3cck 42 23 ATPase ATPase NNP cord-267475-6f4h3cck 42 24 which which WDT cord-267475-6f4h3cck 42 25 might may MD cord-267475-6f4h3cck 42 26 control control VB cord-267475-6f4h3cck 42 27 the the DT cord-267475-6f4h3cck 42 28 hypothetical hypothetical JJ cord-267475-6f4h3cck 42 29 clamp clamp NN cord-267475-6f4h3cck 42 30 . . . cord-267475-6f4h3cck 43 1 Some some DT cord-267475-6f4h3cck 43 2 ideas idea NNS cord-267475-6f4h3cck 43 3 about about IN cord-267475-6f4h3cck 43 4 the the DT cord-267475-6f4h3cck 43 5 function function NN cord-267475-6f4h3cck 43 6 of of IN cord-267475-6f4h3cck 43 7 other other JJ cord-267475-6f4h3cck 43 8 initiation initiation NN cord-267475-6f4h3cck 43 9 factors factor NNS cord-267475-6f4h3cck 43 10 are be VBP cord-267475-6f4h3cck 43 11 reviewed review VBN cord-267475-6f4h3cck 43 12 elsewhere elsewhere RB cord-267475-6f4h3cck 43 13 ( ( -LRB- cord-267475-6f4h3cck 43 14 Dever Dever NNP cord-267475-6f4h3cck 43 15 , , , cord-267475-6f4h3cck 43 16 2002 2002 CD cord-267475-6f4h3cck 43 17 ; ; : cord-267475-6f4h3cck 43 18 McCarthy McCarthy NNP cord-267475-6f4h3cck 43 19 , , , cord-267475-6f4h3cck 43 20 1998 1998 CD cord-267475-6f4h3cck 43 21 ; ; : cord-267475-6f4h3cck 43 22 Pestova Pestova NNP cord-267475-6f4h3cck 43 23 et et NNP cord-267475-6f4h3cck 43 24 al al NNP cord-267475-6f4h3cck 43 25 . . NNP cord-267475-6f4h3cck 43 26 , , , cord-267475-6f4h3cck 43 27 2001 2001 CD cord-267475-6f4h3cck 43 28 ) ) -RRB- cord-267475-6f4h3cck 43 29 . . . cord-267475-6f4h3cck 44 1 The the DT cord-267475-6f4h3cck 44 2 strongest strong JJS cord-267475-6f4h3cck 44 3 evidence evidence NN cord-267475-6f4h3cck 44 4 that that IN cord-267475-6f4h3cck 44 5 the the DT cord-267475-6f4h3cck 44 6 scanning scanning NN cord-267475-6f4h3cck 44 7 40S 40s CD cord-267475-6f4h3cck 44 8 ribosome/ ribosome/ CD cord-267475-6f4h3cck 44 9 factor factor NN cord-267475-6f4h3cck 44 10 complex complex JJ cord-267475-6f4h3cck 44 11 advances advance VBZ cord-267475-6f4h3cck 44 12 linearly linearly RB cord-267475-6f4h3cck 44 13 is be VBZ cord-267475-6f4h3cck 44 14 the the DT cord-267475-6f4h3cck 44 15 position position NN cord-267475-6f4h3cck 44 16 effect effect NN cord-267475-6f4h3cck 44 17 on on IN cord-267475-6f4h3cck 44 18 selection selection NN cord-267475-6f4h3cck 44 19 of of IN cord-267475-6f4h3cck 44 20 the the DT cord-267475-6f4h3cck 44 21 start start NN cord-267475-6f4h3cck 44 22 codon codon NN cord-267475-6f4h3cck 44 23 : : : cord-267475-6f4h3cck 44 24 initiation initiation NN cord-267475-6f4h3cck 44 25 at at IN cord-267475-6f4h3cck 44 26 the the DT cord-267475-6f4h3cck 44 27 first first JJ cord-267475-6f4h3cck 44 28 potential potential JJ cord-267475-6f4h3cck 44 29 start start NN cord-267475-6f4h3cck 44 30 codon codon NN cord-267475-6f4h3cck 44 31 has have VBZ cord-267475-6f4h3cck 44 32 been be VBN cord-267475-6f4h3cck 44 33 demonstrated demonstrate VBN cord-267475-6f4h3cck 44 34 in in IN cord-267475-6f4h3cck 44 35 rigorous rigorous JJ cord-267475-6f4h3cck 44 36 experimental experimental JJ cord-267475-6f4h3cck 44 37 tests test NNS cord-267475-6f4h3cck 44 38 ( ( -LRB- cord-267475-6f4h3cck 44 39 Cigan Cigan NNP cord-267475-6f4h3cck 44 40 et et FW cord-267475-6f4h3cck 44 41 al al NNP cord-267475-6f4h3cck 44 42 . . NNP cord-267475-6f4h3cck 44 43 , , , cord-267475-6f4h3cck 44 44 1988a 1988a CD cord-267475-6f4h3cck 44 45 ; ; : cord-267475-6f4h3cck 44 46 Kozak Kozak NNP cord-267475-6f4h3cck 44 47 , , , cord-267475-6f4h3cck 44 48 1983 1983 CD cord-267475-6f4h3cck 44 49 Kozak Kozak NNP cord-267475-6f4h3cck 44 50 , , , cord-267475-6f4h3cck 44 51 , , , cord-267475-6f4h3cck 44 52 1995 1995 CD cord-267475-6f4h3cck 44 53 and and CC cord-267475-6f4h3cck 44 54 confirmed confirm VBD cord-267475-6f4h3cck 44 55 in in IN cord-267475-6f4h3cck 44 56 many many JJ cord-267475-6f4h3cck 44 57 ' ' POS cord-267475-6f4h3cck 44 58 natural natural JJ cord-267475-6f4h3cck 44 59 tests test NNS cord-267475-6f4h3cck 44 60 ' ' '' cord-267475-6f4h3cck 44 61 wherein wherein WRB cord-267475-6f4h3cck 44 62 addition addition NN cord-267475-6f4h3cck 44 63 or or CC cord-267475-6f4h3cck 44 64 removal removal NN cord-267475-6f4h3cck 44 65 of of IN cord-267475-6f4h3cck 44 66 an an DT cord-267475-6f4h3cck 44 67 AUG AUG NNP cord-267475-6f4h3cck 44 68 codon codon NN cord-267475-6f4h3cck 44 69 produces produce VBZ cord-267475-6f4h3cck 44 70 the the DT cord-267475-6f4h3cck 44 71 expected expect VBN cord-267475-6f4h3cck 44 72 shift shift NN cord-267475-6f4h3cck 44 73 in in IN cord-267475-6f4h3cck 44 74 the the DT cord-267475-6f4h3cck 44 75 site site NN cord-267475-6f4h3cck 44 76 of of IN cord-267475-6f4h3cck 44 77 initiation initiation NN cord-267475-6f4h3cck 44 78 ( ( -LRB- cord-267475-6f4h3cck 44 79 see see VB cord-267475-6f4h3cck 44 80 below below RB cord-267475-6f4h3cck 44 81 ) ) -RRB- cord-267475-6f4h3cck 44 82 . . . cord-267475-6f4h3cck 45 1 The the DT cord-267475-6f4h3cck 45 2 aforementioned aforementioned JJ cord-267475-6f4h3cck 45 3 blockade blockade NN cord-267475-6f4h3cck 45 4 caused cause VBN cord-267475-6f4h3cck 45 5 by by IN cord-267475-6f4h3cck 45 6 inserting insert VBG cord-267475-6f4h3cck 45 7 a a DT cord-267475-6f4h3cck 45 8 base base NN cord-267475-6f4h3cck 45 9 - - HYPH cord-267475-6f4h3cck 45 10 paired pair VBN cord-267475-6f4h3cck 45 11 structure structure NN cord-267475-6f4h3cck 45 12 between between IN cord-267475-6f4h3cck 45 13 the the DT cord-267475-6f4h3cck 45 14 5 5 CD cord-267475-6f4h3cck 45 15 0 0 CD cord-267475-6f4h3cck 45 16 cap cap NN cord-267475-6f4h3cck 45 17 and and CC cord-267475-6f4h3cck 45 18 the the DT cord-267475-6f4h3cck 45 19 AUG AUG NNP cord-267475-6f4h3cck 45 20 START START NNP cord-267475-6f4h3cck 45 21 codon codon NN cord-267475-6f4h3cck 45 22 is be VBZ cord-267475-6f4h3cck 45 23 further further JJ cord-267475-6f4h3cck 45 24 evidence evidence NN cord-267475-6f4h3cck 45 25 that that IN cord-267475-6f4h3cck 45 26 40S 40s CD cord-267475-6f4h3cck 45 27 ribosomal ribosomal JJ cord-267475-6f4h3cck 45 28 subunits subunit NNS cord-267475-6f4h3cck 45 29 traverse traverse VBP cord-267475-6f4h3cck 45 30 the the DT cord-267475-6f4h3cck 45 31 leader leader NN cord-267475-6f4h3cck 45 32 sequence sequence NN cord-267475-6f4h3cck 45 33 linearly linearly RB cord-267475-6f4h3cck 45 34 , , , cord-267475-6f4h3cck 45 35 rather rather RB cord-267475-6f4h3cck 45 36 than than IN cord-267475-6f4h3cck 45 37 hopping hop VBG cord-267475-6f4h3cck 45 38 ( ( -LRB- cord-267475-6f4h3cck 45 39 discontinuous discontinuous JJ cord-267475-6f4h3cck 45 40 scanning scanning NN cord-267475-6f4h3cck 45 41 ) ) -RRB- cord-267475-6f4h3cck 45 42 or or CC cord-267475-6f4h3cck 45 43 entering enter VBG cord-267475-6f4h3cck 45 44 directly directly RB cord-267475-6f4h3cck 45 45 at at IN cord-267475-6f4h3cck 45 46 the the DT cord-267475-6f4h3cck 45 47 AUG AUG NNP cord-267475-6f4h3cck 45 48 codon codon NN cord-267475-6f4h3cck 45 49 . . . cord-267475-6f4h3cck 46 1 Although although IN cord-267475-6f4h3cck 46 2 the the DT cord-267475-6f4h3cck 46 3 scanning scanning NN cord-267475-6f4h3cck 46 4 mechanism mechanism NN cord-267475-6f4h3cck 46 5 predicts predict VBZ cord-267475-6f4h3cck 46 6 that that IN cord-267475-6f4h3cck 46 7 translation translation NN cord-267475-6f4h3cck 46 8 should should MD cord-267475-6f4h3cck 46 9 initiate initiate VB cord-267475-6f4h3cck 46 10 at at IN cord-267475-6f4h3cck 46 11 the the DT cord-267475-6f4h3cck 46 12 AUG AUG NNP cord-267475-6f4h3cck 46 13 codon codon NN cord-267475-6f4h3cck 46 14 nearest nearest IN cord-267475-6f4h3cck 46 15 the the DT cord-267475-6f4h3cck 46 16 5 5 CD cord-267475-6f4h3cck 46 17 0 0 CD cord-267475-6f4h3cck 46 18 end end NN cord-267475-6f4h3cck 46 19 of of IN cord-267475-6f4h3cck 46 20 the the DT cord-267475-6f4h3cck 46 21 mRNA mrna NN cord-267475-6f4h3cck 46 22 , , , cord-267475-6f4h3cck 46 23 two two CD cord-267475-6f4h3cck 46 24 ancillary ancillary JJ cord-267475-6f4h3cck 46 25 mechanisms mechanism NNS cord-267475-6f4h3cck 46 26 -reinitiation -reinitiation CD cord-267475-6f4h3cck 46 27 and and CC cord-267475-6f4h3cck 46 28 context context NN cord-267475-6f4h3cck 46 29 - - HYPH cord-267475-6f4h3cck 46 30 dependent dependent JJ cord-267475-6f4h3cck 46 31 leaky leaky JJ cord-267475-6f4h3cck 46 32 scanning scanning NN cord-267475-6f4h3cck 46 33 -enable -enable JJ cord-267475-6f4h3cck 46 34 additional additional JJ cord-267475-6f4h3cck 46 35 initiation initiation NN cord-267475-6f4h3cck 46 36 events event NNS cord-267475-6f4h3cck 46 37 at at IN cord-267475-6f4h3cck 46 38 downstream downstream JJ cord-267475-6f4h3cck 46 39 AUG AUG NNP cord-267475-6f4h3cck 46 40 codons codon NNS cord-267475-6f4h3cck 46 41 in in IN cord-267475-6f4h3cck 46 42 some some DT cord-267475-6f4h3cck 46 43 mRNAs mrna NNS cord-267475-6f4h3cck 46 44 . . . cord-267475-6f4h3cck 47 1 These these DT cord-267475-6f4h3cck 47 2 well well RB cord-267475-6f4h3cck 47 3 - - HYPH cord-267475-6f4h3cck 47 4 defined define VBN cord-267475-6f4h3cck 47 5 mechanisms mechanism NNS cord-267475-6f4h3cck 47 6 for for IN cord-267475-6f4h3cck 47 7 escaping escape VBG cord-267475-6f4h3cck 47 8 the the DT cord-267475-6f4h3cck 47 9 first first JJ cord-267475-6f4h3cck 47 10 - - HYPH cord-267475-6f4h3cck 47 11 AUG AUG NNP cord-267475-6f4h3cck 47 12 rule rule NN cord-267475-6f4h3cck 47 13 are be VBP cord-267475-6f4h3cck 47 14 discussed discuss VBN cord-267475-6f4h3cck 47 15 below below RB cord-267475-6f4h3cck 47 16 . . . cord-267475-6f4h3cck 48 1 An an DT cord-267475-6f4h3cck 48 2 additional additional JJ cord-267475-6f4h3cck 48 3 escape escape NN cord-267475-6f4h3cck 48 4 mechanism mechanism NN cord-267475-6f4h3cck 48 5 might may MD cord-267475-6f4h3cck 48 6 involve involve VB cord-267475-6f4h3cck 48 7 direct direct JJ cord-267475-6f4h3cck 48 8 entry entry NN cord-267475-6f4h3cck 48 9 of of IN cord-267475-6f4h3cck 48 10 ribosomes ribosome NNS cord-267475-6f4h3cck 48 11 at at IN cord-267475-6f4h3cck 48 12 an an DT cord-267475-6f4h3cck 48 13 internal internal JJ cord-267475-6f4h3cck 48 14 site site NN cord-267475-6f4h3cck 48 15 in in IN cord-267475-6f4h3cck 48 16 the the DT cord-267475-6f4h3cck 48 17 mRNA mrna NN cord-267475-6f4h3cck 48 18 . . . cord-267475-6f4h3cck 49 1 While while IN cord-267475-6f4h3cck 49 2 there there EX cord-267475-6f4h3cck 49 3 is be VBZ cord-267475-6f4h3cck 49 4 evidence evidence NN cord-267475-6f4h3cck 49 5 suggestive suggestive JJ cord-267475-6f4h3cck 49 6 of of IN cord-267475-6f4h3cck 49 7 direct direct JJ cord-267475-6f4h3cck 49 8 internal internal JJ cord-267475-6f4h3cck 49 9 initiation initiation NN cord-267475-6f4h3cck 49 10 with with IN cord-267475-6f4h3cck 49 11 picornavirus picornavirus NNP cord-267475-6f4h3cck 49 12 mRNAs mRNAs NNPS cord-267475-6f4h3cck 49 13 , , , cord-267475-6f4h3cck 49 14 the the DT cord-267475-6f4h3cck 49 15 evidence evidence NN cord-267475-6f4h3cck 49 16 for for IN cord-267475-6f4h3cck 49 17 internal internal JJ cord-267475-6f4h3cck 49 18 ribosome ribosome NN cord-267475-6f4h3cck 49 19 entry entry NN cord-267475-6f4h3cck 49 20 sites site NNS cord-267475-6f4h3cck 49 21 ( ( -LRB- cord-267475-6f4h3cck 49 22 IRES IRES NNP cord-267475-6f4h3cck 49 23 ) ) -RRB- cord-267475-6f4h3cck 49 24 in in IN cord-267475-6f4h3cck 49 25 cellular cellular NN cord-267475-6f4h3cck 49 26 mRNAs mRNAs NNPS cord-267475-6f4h3cck 49 27 is be VBZ cord-267475-6f4h3cck 49 28 problematic problematic JJ cord-267475-6f4h3cck 49 29 ( ( -LRB- cord-267475-6f4h3cck 49 30 Kozak Kozak NNP cord-267475-6f4h3cck 49 31 , , , cord-267475-6f4h3cck 49 32 2001a 2001a CD cord-267475-6f4h3cck 49 33 ) ) -RRB- cord-267475-6f4h3cck 49 34 . . . cord-267475-6f4h3cck 50 1 The the DT cord-267475-6f4h3cck 50 2 absence absence NN cord-267475-6f4h3cck 50 3 of of IN cord-267475-6f4h3cck 50 4 shared share VBN cord-267475-6f4h3cck 50 5 structural structural JJ cord-267475-6f4h3cck 50 6 features feature NNS cord-267475-6f4h3cck 50 7 among among IN cord-267475-6f4h3cck 50 8 candidate candidate NN cord-267475-6f4h3cck 50 9 cellular cellular JJ cord-267475-6f4h3cck 50 10 IRES IRES NNP cord-267475-6f4h3cck 50 11 elements element NNS cord-267475-6f4h3cck 50 12 makes make VBZ cord-267475-6f4h3cck 50 13 it -PRON- PRP cord-267475-6f4h3cck 50 14 impossible impossible JJ cord-267475-6f4h3cck 50 15 to to TO cord-267475-6f4h3cck 50 16 predict predict VB cord-267475-6f4h3cck 50 17 which which WDT cord-267475-6f4h3cck 50 18 mRNAs mrnas XX cord-267475-6f4h3cck 50 19 , , , cord-267475-6f4h3cck 50 20 if if IN cord-267475-6f4h3cck 50 21 any any DT cord-267475-6f4h3cck 50 22 , , , cord-267475-6f4h3cck 50 23 might may MD cord-267475-6f4h3cck 50 24 use use VB cord-267475-6f4h3cck 50 25 such such PDT cord-267475-6f4h3cck 50 26 a a DT cord-267475-6f4h3cck 50 27 mechanism mechanism NN cord-267475-6f4h3cck 50 28 . . . cord-267475-6f4h3cck 51 1 Rather rather RB cord-267475-6f4h3cck 51 2 than than IN cord-267475-6f4h3cck 51 3 attempting attempt VBG cord-267475-6f4h3cck 51 4 to to TO cord-267475-6f4h3cck 51 5 summarize summarize VB cord-267475-6f4h3cck 51 6 the the DT cord-267475-6f4h3cck 51 7 extensive extensive JJ cord-267475-6f4h3cck 51 8 literature literature NN cord-267475-6f4h3cck 51 9 on on IN cord-267475-6f4h3cck 51 10 internal internal JJ cord-267475-6f4h3cck 51 11 initiation initiation NN cord-267475-6f4h3cck 51 12 , , , cord-267475-6f4h3cck 51 13 I -PRON- PRP cord-267475-6f4h3cck 51 14 refer refer VBP cord-267475-6f4h3cck 51 15 the the DT cord-267475-6f4h3cck 51 16 reader reader NN cord-267475-6f4h3cck 51 17 to to IN cord-267475-6f4h3cck 51 18 other other JJ cord-267475-6f4h3cck 51 19 detailed detailed JJ cord-267475-6f4h3cck 51 20 reviews review NNS cord-267475-6f4h3cck 51 21 on on IN cord-267475-6f4h3cck 51 22 that that DT cord-267475-6f4h3cck 51 23 subject subject NN cord-267475-6f4h3cck 51 24 ( ( -LRB- cord-267475-6f4h3cck 51 25 Dever Dever NNP cord-267475-6f4h3cck 51 26 , , , cord-267475-6f4h3cck 51 27 2002 2002 CD cord-267475-6f4h3cck 51 28 ; ; : cord-267475-6f4h3cck 51 29 Hellen Hellen NNP cord-267475-6f4h3cck 51 30 and and CC cord-267475-6f4h3cck 51 31 Sarnow Sarnow NNP cord-267475-6f4h3cck 51 32 , , , cord-267475-6f4h3cck 51 33 2001 2001 CD cord-267475-6f4h3cck 51 34 ; ; : cord-267475-6f4h3cck 51 35 Pestova Pestova NNP cord-267475-6f4h3cck 51 36 et et NNP cord-267475-6f4h3cck 51 37 al al NNP cord-267475-6f4h3cck 51 38 . . NNP cord-267475-6f4h3cck 51 39 , , , cord-267475-6f4h3cck 51 40 2001 2001 CD cord-267475-6f4h3cck 51 41 ) ) -RRB- cord-267475-6f4h3cck 51 42 . . . cord-267475-6f4h3cck 52 1 The the DT cord-267475-6f4h3cck 52 2 next next JJ cord-267475-6f4h3cck 52 3 section section NN cord-267475-6f4h3cck 52 4 provides provide VBZ cord-267475-6f4h3cck 52 5 a a DT cord-267475-6f4h3cck 52 6 terse terse JJ cord-267475-6f4h3cck 52 7 summary summary NN cord-267475-6f4h3cck 52 8 of of IN cord-267475-6f4h3cck 52 9 points point NNS cord-267475-6f4h3cck 52 10 that that WDT cord-267475-6f4h3cck 52 11 are be VBP cord-267475-6f4h3cck 52 12 easily easily RB cord-267475-6f4h3cck 52 13 explained explain VBN cord-267475-6f4h3cck 52 14 by by IN cord-267475-6f4h3cck 52 15 the the DT cord-267475-6f4h3cck 52 16 scanning scanning NN cord-267475-6f4h3cck 52 17 model model NN cord-267475-6f4h3cck 52 18 . . . cord-267475-6f4h3cck 53 1 The the DT cord-267475-6f4h3cck 53 2 bulk bulk NN cord-267475-6f4h3cck 53 3 of of IN cord-267475-6f4h3cck 53 4 the the DT cord-267475-6f4h3cck 53 5 review review NN cord-267475-6f4h3cck 53 6 then then RB cord-267475-6f4h3cck 53 7 focuses focus VBZ cord-267475-6f4h3cck 53 8 on on IN cord-267475-6f4h3cck 53 9 complicated complicated JJ cord-267475-6f4h3cck 53 10 examples example NNS cord-267475-6f4h3cck 53 11 and and CC cord-267475-6f4h3cck 53 12 issues issue NNS cord-267475-6f4h3cck 53 13 . . . cord-267475-6f4h3cck 54 1 2 2 LS cord-267475-6f4h3cck 54 2 . . . cord-267475-6f4h3cck 55 1 Constraints constraint NNS cord-267475-6f4h3cck 55 2 imposed impose VBN cord-267475-6f4h3cck 55 3 by by IN cord-267475-6f4h3cck 55 4 the the DT cord-267475-6f4h3cck 55 5 scanning scanning NN cord-267475-6f4h3cck 55 6 mechanism mechanism NN cord-267475-6f4h3cck 55 7 explain explain VBP cord-267475-6f4h3cck 55 8 many many JJ cord-267475-6f4h3cck 55 9 common common JJ cord-267475-6f4h3cck 55 10 aspects aspect NNS cord-267475-6f4h3cck 55 11 of of IN cord-267475-6f4h3cck 55 12 gene gene NN cord-267475-6f4h3cck 55 13 expression expression NN cord-267475-6f4h3cck 55 14 in in IN cord-267475-6f4h3cck 55 15 higher high JJR cord-267475-6f4h3cck 55 16 eukaryotes eukaryote NNS cord-267475-6f4h3cck 56 1 Many many JJ cord-267475-6f4h3cck 56 2 plant plant NN cord-267475-6f4h3cck 56 3 and and CC cord-267475-6f4h3cck 56 4 animal animal NN cord-267475-6f4h3cck 56 5 viruses virus NNS cord-267475-6f4h3cck 56 6 produce produce VBP cord-267475-6f4h3cck 56 7 dicistronic dicistronic JJ cord-267475-6f4h3cck 56 8 or or CC cord-267475-6f4h3cck 56 9 polycistronic polycistronic NN cord-267475-6f4h3cck 56 10 mRNAs mRNAs NNPS cord-267475-6f4h3cck 56 11 from from IN cord-267475-6f4h3cck 56 12 which which WDT cord-267475-6f4h3cck 56 13 only only RB cord-267475-6f4h3cck 56 14 the the DT cord-267475-6f4h3cck 56 15 5 5 CD cord-267475-6f4h3cck 56 16 0 0 CD cord-267475-6f4h3cck 56 17 cistron cistron NN cord-267475-6f4h3cck 56 18 can can MD cord-267475-6f4h3cck 56 19 be be VB cord-267475-6f4h3cck 56 20 translated translate VBN cord-267475-6f4h3cck 56 21 ( ( -LRB- cord-267475-6f4h3cck 56 22 Table table NN cord-267475-6f4h3cck 56 23 1 1 CD cord-267475-6f4h3cck 56 24 ) ) -RRB- cord-267475-6f4h3cck 56 25 . . . cord-267475-6f4h3cck 57 1 All all PDT cord-267475-6f4h3cck 57 2 these these DT cord-267475-6f4h3cck 57 3 viruses virus NNS cord-267475-6f4h3cck 57 4 solve solve VBP cord-267475-6f4h3cck 57 5 the the DT cord-267475-6f4h3cck 57 6 problem problem NN cord-267475-6f4h3cck 57 7 of of IN cord-267475-6f4h3cck 57 8 ' ' `` cord-267475-6f4h3cck 57 9 silent silent JJ cord-267475-6f4h3cck 57 10 3 3 CD cord-267475-6f4h3cck 57 11 0 0 CD cord-267475-6f4h3cck 57 12 cistrons cistron NNS cord-267475-6f4h3cck 57 13 ' ' '' cord-267475-6f4h3cck 57 14 by by IN cord-267475-6f4h3cck 57 15 producing produce VBG cord-267475-6f4h3cck 57 16 -via -via DT cord-267475-6f4h3cck 57 17 splicing splice VBG cord-267475-6f4h3cck 57 18 or or CC cord-267475-6f4h3cck 57 19 discontinuous discontinuous JJ cord-267475-6f4h3cck 57 20 transcription transcription NN cord-267475-6f4h3cck 57 21 or or CC cord-267475-6f4h3cck 57 22 an an DT cord-267475-6f4h3cck 57 23 internal internal JJ cord-267475-6f4h3cck 57 24 promoteradditional promoteradditional JJ cord-267475-6f4h3cck 57 25 forms form NNS cord-267475-6f4h3cck 57 26 of of IN cord-267475-6f4h3cck 57 27 mRNA mrna NN cord-267475-6f4h3cck 57 28 in in IN cord-267475-6f4h3cck 57 29 which which WDT cord-267475-6f4h3cck 57 30 the the DT cord-267475-6f4h3cck 57 31 downstream downstream JJ cord-267475-6f4h3cck 57 32 cistron cistron NN cord-267475-6f4h3cck 57 33 is be VBZ cord-267475-6f4h3cck 57 34 repositioned reposition VBN cord-267475-6f4h3cck 57 35 closer close RBR cord-267475-6f4h3cck 57 36 to to IN cord-267475-6f4h3cck 57 37 the the DT cord-267475-6f4h3cck 57 38 5 5 CD cord-267475-6f4h3cck 57 39 0 0 CD cord-267475-6f4h3cck 57 40 end end NN cord-267475-6f4h3cck 57 41 . . . cord-267475-6f4h3cck 58 1 The the DT cord-267475-6f4h3cck 58 2 reason reason NN cord-267475-6f4h3cck 58 3 for for IN cord-267475-6f4h3cck 58 4 the the DT cord-267475-6f4h3cck 58 5 complicated complicated JJ cord-267475-6f4h3cck 58 6 pattern pattern NN cord-267475-6f4h3cck 58 7 of of IN cord-267475-6f4h3cck 58 8 splicing splicing NN cord-267475-6f4h3cck 58 9 seen see VBN cord-267475-6f4h3cck 58 10 with with IN cord-267475-6f4h3cck 58 11 human human JJ cord-267475-6f4h3cck 58 12 immunodeficiency immunodeficiency NN cord-267475-6f4h3cck 58 13 virus virus NN cord-267475-6f4h3cck 58 14 type type NN cord-267475-6f4h3cck 58 15 1 1 CD cord-267475-6f4h3cck 58 16 ( ( -LRB- cord-267475-6f4h3cck 58 17 HIV-1 HIV-1 NNP cord-267475-6f4h3cck 58 18 ) ) -RRB- cord-267475-6f4h3cck 58 19 , , , cord-267475-6f4h3cck 58 20 for for IN cord-267475-6f4h3cck 58 21 example example NN cord-267475-6f4h3cck 58 22 , , , cord-267475-6f4h3cck 58 23 is be VBZ cord-267475-6f4h3cck 58 24 simply simply RB cord-267475-6f4h3cck 58 25 to to TO cord-267475-6f4h3cck 58 26 produce produce VB cord-267475-6f4h3cck 58 27 mRNAs mrna NNS cord-267475-6f4h3cck 58 28 that that WDT cord-267475-6f4h3cck 58 29 allow allow VBP cord-267475-6f4h3cck 58 30 downstream downstream JJ cord-267475-6f4h3cck 58 31 open open JJ cord-267475-6f4h3cck 58 32 reading reading NN cord-267475-6f4h3cck 58 33 frames frame NNS cord-267475-6f4h3cck 58 34 ( ( -LRB- cord-267475-6f4h3cck 58 35 ORFs ORFs NNP cord-267475-6f4h3cck 58 36 ) ) -RRB- cord-267475-6f4h3cck 58 37 to to TO cord-267475-6f4h3cck 58 38 be be VB cord-267475-6f4h3cck 58 39 translated translate VBN cord-267475-6f4h3cck 58 40 . . . cord-267475-6f4h3cck 59 1 The the DT cord-267475-6f4h3cck 59 2 broad broad JJ cord-267475-6f4h3cck 59 3 range range NN cord-267475-6f4h3cck 59 4 of of IN cord-267475-6f4h3cck 59 5 viruses virus NNS cord-267475-6f4h3cck 59 6 represented represent VBN cord-267475-6f4h3cck 59 7 in in IN cord-267475-6f4h3cck 59 8 Table Table NNP cord-267475-6f4h3cck 59 9 1 1 CD cord-267475-6f4h3cck 59 10 merits merit NNS cord-267475-6f4h3cck 59 11 attention attention NN cord-267475-6f4h3cck 59 12 . . . cord-267475-6f4h3cck 60 1 The the DT cord-267475-6f4h3cck 60 2 same same JJ cord-267475-6f4h3cck 60 3 problem problem NN cord-267475-6f4h3cck 60 4 and and CC cord-267475-6f4h3cck 60 5 same same JJ cord-267475-6f4h3cck 60 6 solution solution NN cord-267475-6f4h3cck 60 7 -post -post HYPH cord-267475-6f4h3cck 60 8 - - JJ cord-267475-6f4h3cck 60 9 transcriptional transcriptional JJ cord-267475-6f4h3cck 60 10 processing processing NN cord-267475-6f4h3cck 60 11 of of IN cord-267475-6f4h3cck 60 12 polycistronic polycistronic NNP cord-267475-6f4h3cck 60 13 mRNAs mrnas POS cord-267475-6f4h3cck 60 14 -underlie -underlie . cord-267475-6f4h3cck 61 1 the the DT cord-267475-6f4h3cck 61 2 expression expression NN cord-267475-6f4h3cck 61 3 of of IN cord-267475-6f4h3cck 61 4 many many JJ cord-267475-6f4h3cck 61 5 genes gene NNS cord-267475-6f4h3cck 61 6 in in IN cord-267475-6f4h3cck 61 7 Caenorhabditis Caenorhabditis NNP cord-267475-6f4h3cck 61 8 elegans elegan NNS cord-267475-6f4h3cck 62 1 ( ( -LRB- cord-267475-6f4h3cck 62 2 Blumenthal Blumenthal NNP cord-267475-6f4h3cck 62 3 et et NNP cord-267475-6f4h3cck 62 4 al al NNP cord-267475-6f4h3cck 62 5 . . NNP cord-267475-6f4h3cck 62 6 , , , cord-267475-6f4h3cck 62 7 2002 2002 CD cord-267475-6f4h3cck 62 8 ; ; : cord-267475-6f4h3cck 63 1 Hough Hough NNP cord-267475-6f4h3cck 63 2 et et NNP cord-267475-6f4h3cck 63 3 al al NNP cord-267475-6f4h3cck 63 4 . . NNP cord-267475-6f4h3cck 63 5 , , , cord-267475-6f4h3cck 63 6 1999 1999 CD cord-267475-6f4h3cck 63 7 ) ) -RRB- cord-267475-6f4h3cck 63 8 . . . cord-267475-6f4h3cck 64 1 In in IN cord-267475-6f4h3cck 64 2 mammalian mammalian JJ cord-267475-6f4h3cck 64 3 cells cell NNS cord-267475-6f4h3cck 64 4 , , , cord-267475-6f4h3cck 64 5 mRNAs mrnas XX cord-267475-6f4h3cck 64 6 that that WDT cord-267475-6f4h3cck 64 7 contain contain VBP cord-267475-6f4h3cck 64 8 two two CD cord-267475-6f4h3cck 64 9 full full JJ cord-267475-6f4h3cck 64 10 - - HYPH cord-267475-6f4h3cck 64 11 length length NN cord-267475-6f4h3cck 64 12 nonoverlapping nonoverlapping NN cord-267475-6f4h3cck 64 13 cistrons cistron NNS cord-267475-6f4h3cck 64 14 are be VBP cord-267475-6f4h3cck 64 15 extremely extremely RB cord-267475-6f4h3cck 64 16 rare rare JJ cord-267475-6f4h3cck 64 17 and and CC cord-267475-6f4h3cck 64 18 , , , cord-267475-6f4h3cck 64 19 as as IN cord-267475-6f4h3cck 64 20 with with IN cord-267475-6f4h3cck 64 21 the the DT cord-267475-6f4h3cck 64 22 aforementioned aforementioned JJ cord-267475-6f4h3cck 64 23 viruses virus NNS cord-267475-6f4h3cck 64 24 , , , cord-267475-6f4h3cck 64 25 actual actual JJ cord-267475-6f4h3cck 64 26 translation translation NN cord-267475-6f4h3cck 64 27 of of IN cord-267475-6f4h3cck 64 28 the the DT cord-267475-6f4h3cck 64 29 3 3 CD cord-267475-6f4h3cck 64 30 0 0 CD cord-267475-6f4h3cck 64 31 cistron cistron NNP cord-267475-6f4h3cck 64 32 probably probably RB cord-267475-6f4h3cck 64 33 occurs occur VBZ cord-267475-6f4h3cck 64 34 from from IN cord-267475-6f4h3cck 64 35 a a DT cord-267475-6f4h3cck 64 36 second second JJ cord-267475-6f4h3cck 64 37 , , , cord-267475-6f4h3cck 64 38 monocistronic monocistronic NNP cord-267475-6f4h3cck 64 39 mRNA mRNA NNP cord-267475-6f4h3cck 65 1 ( ( -LRB- cord-267475-6f4h3cck 65 2 Pardigol Pardigol NNP cord-267475-6f4h3cck 65 3 et et NNP cord-267475-6f4h3cck 65 4 al al NNP cord-267475-6f4h3cck 65 5 . . NNP cord-267475-6f4h3cck 65 6 , , , cord-267475-6f4h3cck 65 7 1998 1998 CD cord-267475-6f4h3cck 65 8 ; ; : cord-267475-6f4h3cck 65 9 Westerman Westerman NNP cord-267475-6f4h3cck 65 10 et et NNP cord-267475-6f4h3cck 65 11 al al NNP cord-267475-6f4h3cck 65 12 . . NNP cord-267475-6f4h3cck 65 13 , , , cord-267475-6f4h3cck 65 14 2001 2001 CD cord-267475-6f4h3cck 65 15 ) ) -RRB- cord-267475-6f4h3cck 65 16 or or CC cord-267475-6f4h3cck 65 17 from from IN cord-267475-6f4h3cck 65 18 a a DT cord-267475-6f4h3cck 65 19 second second JJ cord-267475-6f4h3cck 65 20 mRNA mrna NN cord-267475-6f4h3cck 65 21 in in IN cord-267475-6f4h3cck 65 22 which which WDT cord-267475-6f4h3cck 65 23 the the DT cord-267475-6f4h3cck 65 24 two two CD cord-267475-6f4h3cck 65 25 cistrons cistron NNS cord-267475-6f4h3cck 65 26 are be VBP cord-267475-6f4h3cck 65 27 fused fuse VBN cord-267475-6f4h3cck 65 28 into into IN cord-267475-6f4h3cck 65 29 a a DT cord-267475-6f4h3cck 65 30 single single JJ cord-267475-6f4h3cck 65 31 translation translation NN cord-267475-6f4h3cck 65 32 unit unit NN cord-267475-6f4h3cck 65 33 ( ( -LRB- cord-267475-6f4h3cck 65 34 Gray Gray NNP cord-267475-6f4h3cck 65 35 and and CC cord-267475-6f4h3cck 65 36 Nicholls Nicholls NNP cord-267475-6f4h3cck 65 37 , , , cord-267475-6f4h3cck 65 38 2000 2000 CD cord-267475-6f4h3cck 65 39 ; ; : cord-267475-6f4h3cck 65 40 Hänzelmann Hänzelmann NNP cord-267475-6f4h3cck 65 41 et et NNP cord-267475-6f4h3cck 65 42 al al NNP cord-267475-6f4h3cck 65 43 . . NNP cord-267475-6f4h3cck 65 44 , , , cord-267475-6f4h3cck 65 45 2002 2002 CD cord-267475-6f4h3cck 65 46 ) ) -RRB- cord-267475-6f4h3cck 65 47 . . . cord-267475-6f4h3cck 66 1 A a DT cord-267475-6f4h3cck 66 2 dicistronic dicistronic JJ cord-267475-6f4h3cck 66 3 transcript transcript NN cord-267475-6f4h3cck 66 4 derived derive VBN cord-267475-6f4h3cck 66 5 from from IN cord-267475-6f4h3cck 66 6 the the DT cord-267475-6f4h3cck 66 7 mouse mouse NN cord-267475-6f4h3cck 66 8 Snurf Snurf NNP cord-267475-6f4h3cck 66 9 - - HYPH cord-267475-6f4h3cck 66 10 Snrpn Snrpn NNP cord-267475-6f4h3cck 66 11 locus locus NN cord-267475-6f4h3cck 66 12 barely barely RB cord-267475-6f4h3cck 66 13 supports support VBZ cord-267475-6f4h3cck 66 14 translation translation NN cord-267475-6f4h3cck 66 15 of of IN cord-267475-6f4h3cck 66 16 the the DT cord-267475-6f4h3cck 66 17 second second JJ cord-267475-6f4h3cck 66 18 cistron cistron NN cord-267475-6f4h3cck 66 19 , , , cord-267475-6f4h3cck 66 20 as as IN cord-267475-6f4h3cck 66 21 discussed discuss VBN cord-267475-6f4h3cck 66 22 below below RB cord-267475-6f4h3cck 66 23 in in IN cord-267475-6f4h3cck 66 24 the the DT cord-267475-6f4h3cck 66 25 section section NN cord-267475-6f4h3cck 66 26 on on IN cord-267475-6f4h3cck 66 27 reinitiation reinitiation NN cord-267475-6f4h3cck 66 28 ( ( -LRB- cord-267475-6f4h3cck 66 29 Section section NN cord-267475-6f4h3cck 66 30 4 4 CD cord-267475-6f4h3cck 66 31 ) ) -RRB- cord-267475-6f4h3cck 66 32 . . . cord-267475-6f4h3cck 67 1 Recently recently RB cord-267475-6f4h3cck 67 2 discovered discover VBN cord-267475-6f4h3cck 67 3 dicistronic dicistronic JJ cord-267475-6f4h3cck 67 4 transcripts transcript NNS cord-267475-6f4h3cck 67 5 produced produce VBN cord-267475-6f4h3cck 67 6 from from IN cord-267475-6f4h3cck 67 7 the the DT cord-267475-6f4h3cck 67 8 mouse mouse NN cord-267475-6f4h3cck 67 9 Hyal Hyal NNP cord-267475-6f4h3cck 67 10 locus locus NN cord-267475-6f4h3cck 67 11 support support NN cord-267475-6f4h3cck 67 12 translation translation NN cord-267475-6f4h3cck 67 13 of of IN cord-267475-6f4h3cck 67 14 only only RB cord-267475-6f4h3cck 67 15 the the DT cord-267475-6f4h3cck 67 16 5 5 CD cord-267475-6f4h3cck 67 17 0 0 CD cord-267475-6f4h3cck 67 18 cistron cistron NN cord-267475-6f4h3cck 67 19 ( ( -LRB- cord-267475-6f4h3cck 67 20 Shuttleworth Shuttleworth NNP cord-267475-6f4h3cck 67 21 et et NNP cord-267475-6f4h3cck 67 22 al al NNP cord-267475-6f4h3cck 67 23 . . NNP cord-267475-6f4h3cck 67 24 , , , cord-267475-6f4h3cck 67 25 2002 2002 CD cord-267475-6f4h3cck 67 26 ) ) -RRB- cord-267475-6f4h3cck 67 27 . . . cord-267475-6f4h3cck 68 1 A a DT cord-267475-6f4h3cck 68 2 few few JJ cord-267475-6f4h3cck 68 3 other other JJ cord-267475-6f4h3cck 68 4 reported report VBN cord-267475-6f4h3cck 68 5 dicistronic dicistronic JJ cord-267475-6f4h3cck 68 6 mRNAs mrnas PRP cord-267475-6f4h3cck 68 7 await await VBP cord-267475-6f4h3cck 68 8 testing test VBG cord-267475-6f4h3cck 68 9 . . . cord-267475-6f4h3cck 69 1 Wold Wold NNP cord-267475-6f4h3cck 69 2 et et NNP cord-267475-6f4h3cck 69 3 al al NNP cord-267475-6f4h3cck 69 4 . . NNP cord-267475-6f4h3cck 69 5 , , , cord-267475-6f4h3cck 69 6 1995 1995 CD cord-267475-6f4h3cck 69 7 ; ; : cord-267475-6f4h3cck 69 8 Ziff Ziff NNP cord-267475-6f4h3cck 69 9 , , , cord-267475-6f4h3cck 69 10 1985 1985 CD cord-267475-6f4h3cck 69 11 Parvovirus parvovirus NN cord-267475-6f4h3cck 69 12 : : : cord-267475-6f4h3cck 69 13 adeno adeno NN cord-267475-6f4h3cck 69 14 - - HYPH cord-267475-6f4h3cck 69 15 associated associate VBN cord-267475-6f4h3cck 69 16 Capsid Capsid NNP cord-267475-6f4h3cck 69 17 protein protein NN cord-267475-6f4h3cck 70 1 A a DT cord-267475-6f4h3cck 71 1 Capsid capsid NN cord-267475-6f4h3cck 71 2 proteins protein NNS cord-267475-6f4h3cck 71 3 B b NN cord-267475-6f4h3cck 71 4 / / SYM cord-267475-6f4h3cck 71 5 C C NNP cord-267475-6f4h3cck 71 6 Splicing Splicing NNP cord-267475-6f4h3cck 71 7 Muralidhar Muralidhar NNP cord-267475-6f4h3cck 71 8 et et NNP cord-267475-6f4h3cck 71 9 al al NNP cord-267475-6f4h3cck 71 10 . . . cord-267475-6f4h3cck 72 1 , , , cord-267475-6f4h3cck 72 2 1994 1994 CD cord-267475-6f4h3cck 72 3 Hepatitis Hepatitis NNP cord-267475-6f4h3cck 72 4 B B NNP cord-267475-6f4h3cck 72 5 virus virus NN cord-267475-6f4h3cck 73 1 Core core NN cord-267475-6f4h3cck 73 2 protein protein NN cord-267475-6f4h3cck 73 3 S s NN cord-267475-6f4h3cck 73 4 proteins protein NNS cord-267475-6f4h3cck 73 5 ( ( -LRB- cord-267475-6f4h3cck 73 6 envelope envelope NN cord-267475-6f4h3cck 73 7 ) ) -RRB- cord-267475-6f4h3cck 73 8 Promoter promoter NN cord-267475-6f4h3cck 73 9 switch switch VBP cord-267475-6f4h3cck 73 10 Schaller Schaller NNP cord-267475-6f4h3cck 73 11 and and CC cord-267475-6f4h3cck 73 12 Fischer Fischer NNP cord-267475-6f4h3cck 73 13 , , , cord-267475-6f4h3cck 73 14 1991 1991 CD cord-267475-6f4h3cck 73 15 Retrovirus retrovirus NN cord-267475-6f4h3cck 73 16 : : : cord-267475-6f4h3cck 73 17 avian avian JJ cord-267475-6f4h3cck 73 18 , , , cord-267475-6f4h3cck 73 19 murine murine JJ cord-267475-6f4h3cck 73 20 Gag gag NN cord-267475-6f4h3cck 73 21 ( ( -LRB- cord-267475-6f4h3cck 73 22 capsid capsid NN cord-267475-6f4h3cck 73 23 ) ) -RRB- cord-267475-6f4h3cck 73 24 protein protein NN cord-267475-6f4h3cck 73 25 Env Env NNP cord-267475-6f4h3cck 73 26 protein protein NN cord-267475-6f4h3cck 73 27 Splicing splicing NN cord-267475-6f4h3cck 73 28 e e LS cord-267475-6f4h3cck 73 29 Pawson Pawson NNP cord-267475-6f4h3cck 73 30 et et NNP cord-267475-6f4h3cck 73 31 al al NNP cord-267475-6f4h3cck 73 32 . . . cord-267475-6f4h3cck 74 1 , , , cord-267475-6f4h3cck 74 2 1977 1977 CD cord-267475-6f4h3cck 74 3 ; ; : cord-267475-6f4h3cck 74 4 Van Van NNP cord-267475-6f4h3cck 74 5 Zaane Zaane NNP cord-267475-6f4h3cck 74 6 et et NNP cord-267475-6f4h3cck 74 7 al al NNP cord-267475-6f4h3cck 74 8 . . NNP cord-267475-6f4h3cck 74 9 , , , cord-267475-6f4h3cck 75 1 1977 1977 CD cord-267475-6f4h3cck 76 1 Retrovirus retrovirus NN cord-267475-6f4h3cck 76 2 : : : cord-267475-6f4h3cck 76 3 human human JJ cord-267475-6f4h3cck 76 4 foamy foamy NN cord-267475-6f4h3cck 76 5 Gag gag NN cord-267475-6f4h3cck 76 6 ( ( -LRB- cord-267475-6f4h3cck 76 7 capsid capsid NN cord-267475-6f4h3cck 76 8 ) ) -RRB- cord-267475-6f4h3cck 76 9 protein protein NN cord-267475-6f4h3cck 76 10 Pol Pol NNP cord-267475-6f4h3cck 76 11 precursor precursor NN cord-267475-6f4h3cck 77 1 Splicing splice VBG cord-267475-6f4h3cck 77 2 Jordan Jordan NNP cord-267475-6f4h3cck 77 3 et et NNP cord-267475-6f4h3cck 77 4 al al NNP cord-267475-6f4h3cck 77 5 . . NNP cord-267475-6f4h3cck 77 6 , , , cord-267475-6f4h3cck 77 7 1996 1996 CD cord-267475-6f4h3cck 78 1 Lentivirus lentivirus NN cord-267475-6f4h3cck 78 2 : : : cord-267475-6f4h3cck 79 1 HIV-1 HIV-1 NNP cord-267475-6f4h3cck 79 2 Tat Tat NNP cord-267475-6f4h3cck 79 3 Rev Rev NNP cord-267475-6f4h3cck 79 4 and and CC cord-267475-6f4h3cck 79 5 Nef Nef NNP cord-267475-6f4h3cck 79 6 f f NNP cord-267475-6f4h3cck 79 7 Splicing splice VBG cord-267475-6f4h3cck 79 8 Schwartz Schwartz NNP cord-267475-6f4h3cck 79 9 et et NNP cord-267475-6f4h3cck 79 10 al al NNP cord-267475-6f4h3cck 79 11 . . . cord-267475-6f4h3cck 80 1 , , , cord-267475-6f4h3cck 80 2 1992 1992 CD cord-267475-6f4h3cck 81 1 Alphavirus Alphavirus NNP cord-267475-6f4h3cck 81 2 : : : cord-267475-6f4h3cck 82 1 Semliki Semliki NNP cord-267475-6f4h3cck 82 2 Forest Forest NNP cord-267475-6f4h3cck 82 3 Nonstructural Nonstructural NNP cord-267475-6f4h3cck 82 4 proteins protein NNS cord-267475-6f4h3cck 83 1 Capsid capsid NN cord-267475-6f4h3cck 83 2 protein protein NN cord-267475-6f4h3cck 83 3 Internal internal JJ cord-267475-6f4h3cck 83 4 promoter promoter NN cord-267475-6f4h3cck 83 5 Glanville Glanville NNP cord-267475-6f4h3cck 83 6 et et NNP cord-267475-6f4h3cck 83 7 al al NNP cord-267475-6f4h3cck 83 8 . . NNP cord-267475-6f4h3cck 83 9 , , , cord-267475-6f4h3cck 83 10 1976 1976 CD cord-267475-6f4h3cck 83 11 ; ; : cord-267475-6f4h3cck 83 12 Strauss Strauss NNP cord-267475-6f4h3cck 83 13 and and CC cord-267475-6f4h3cck 83 14 Strauss Strauss NNP cord-267475-6f4h3cck 83 15 , , , cord-267475-6f4h3cck 83 16 1994 1994 CD cord-267475-6f4h3cck 83 17 Calicivirus Calicivirus NNP cord-267475-6f4h3cck 83 18 : : : cord-267475-6f4h3cck 83 19 feline feline JJ cord-267475-6f4h3cck 83 20 g g NNP cord-267475-6f4h3cck 83 21 Nonstructural nonstructural JJ cord-267475-6f4h3cck 83 22 proteins protein NNS cord-267475-6f4h3cck 84 1 Capsid capsid JJ cord-267475-6f4h3cck 84 2 protein protein NN cord-267475-6f4h3cck 85 1 Independent independent JJ cord-267475-6f4h3cck 85 2 replication replication NN cord-267475-6f4h3cck 85 3 Carter Carter NNP cord-267475-6f4h3cck 85 4 , , , cord-267475-6f4h3cck 85 5 1990 1990 CD cord-267475-6f4h3cck 85 6 ; ; : cord-267475-6f4h3cck 85 7 Neill Neill NNP cord-267475-6f4h3cck 85 8 et et NNP cord-267475-6f4h3cck 85 9 al al NNP cord-267475-6f4h3cck 85 10 . . NNP cord-267475-6f4h3cck 85 11 , , , cord-267475-6f4h3cck 85 12 1991 1991 CD cord-267475-6f4h3cck 86 1 Miller Miller NNP cord-267475-6f4h3cck 86 2 et et NNP cord-267475-6f4h3cck 86 3 al al NNP cord-267475-6f4h3cck 86 4 . . NNP cord-267475-6f4h3cck 86 5 , , , cord-267475-6f4h3cck 86 6 1985 1985 CD cord-267475-6f4h3cck 86 7 ; ; : cord-267475-6f4h3cck 86 8 Shih Shih NNP cord-267475-6f4h3cck 86 9 and and CC cord-267475-6f4h3cck 86 10 Kaesberg Kaesberg NNP cord-267475-6f4h3cck 86 11 , , , cord-267475-6f4h3cck 86 12 1976 1976 CD cord-267475-6f4h3cck 86 13 Tobacco tobacco NN cord-267475-6f4h3cck 86 14 mosaic mosaic NN cord-267475-6f4h3cck 86 15 virus virus NN cord-267475-6f4h3cck 86 16 Replicase Replicase NNP cord-267475-6f4h3cck 86 17 Coat Coat NNP cord-267475-6f4h3cck 86 18 and and CC cord-267475-6f4h3cck 86 19 movement movement NN cord-267475-6f4h3cck 86 20 proteins protein NNS cord-267475-6f4h3cck 87 1 Internal internal JJ cord-267475-6f4h3cck 87 2 promoters promoter NNS cord-267475-6f4h3cck 88 1 Grdzelishvili Grdzelishvili NNP cord-267475-6f4h3cck 88 2 et et NNP cord-267475-6f4h3cck 88 3 al al NNP cord-267475-6f4h3cck 88 4 . . . cord-267475-6f4h3cck 89 1 , , , cord-267475-6f4h3cck 89 2 2000 2000 CD cord-267475-6f4h3cck 89 3 ; ; : cord-267475-6f4h3cck 89 4 Hunter Hunter NNP cord-267475-6f4h3cck 89 5 et et NNP cord-267475-6f4h3cck 89 6 al al NNP cord-267475-6f4h3cck 89 7 . . . cord-267475-6f4h3cck 90 1 , , , cord-267475-6f4h3cck 90 2 1976 1976 CD cord-267475-6f4h3cck 90 3 Potato Potato NNP cord-267475-6f4h3cck 90 4 virus virus NN cord-267475-6f4h3cck 90 5 X x NN cord-267475-6f4h3cck 91 1 25 25 CD cord-267475-6f4h3cck 91 2 kDa kDa NNP cord-267475-6f4h3cck 91 3 movement movement NN cord-267475-6f4h3cck 91 4 protein protein NN cord-267475-6f4h3cck 91 5 12 12 CD cord-267475-6f4h3cck 91 6 and and CC cord-267475-6f4h3cck 91 7 8 8 CD cord-267475-6f4h3cck 91 8 kDa kDa NNP cord-267475-6f4h3cck 91 9 movement movement NN cord-267475-6f4h3cck 91 10 proteins protein NNS cord-267475-6f4h3cck 91 11 f f NNP cord-267475-6f4h3cck 91 12 ? ? . cord-267475-6f4h3cck 91 13 ? ? . cord-267475-6f4h3cck 92 1 Verchot Verchot NNP cord-267475-6f4h3cck 92 2 et et NNP cord-267475-6f4h3cck 92 3 al al NNP cord-267475-6f4h3cck 92 4 . . NNP cord-267475-6f4h3cck 92 5 , , , cord-267475-6f4h3cck 92 6 1998 1998 CD cord-267475-6f4h3cck 92 7 Carmovirus Carmovirus NNP cord-267475-6f4h3cck 92 8 : : : cord-267475-6f4h3cck 92 9 turnip turnip NN cord-267475-6f4h3cck 92 10 crinkle crinkle NN cord-267475-6f4h3cck 92 11 g g NNP cord-267475-6f4h3cck 92 12 Replicase Replicase NNP cord-267475-6f4h3cck 92 13 ( ( -LRB- cord-267475-6f4h3cck 92 14 p28 p28 CD cord-267475-6f4h3cck 92 15 / / SYM cord-267475-6f4h3cck 92 16 p88 p88 NNP cord-267475-6f4h3cck 92 17 ) ) -RRB- cord-267475-6f4h3cck 92 18 p8 p8 NN cord-267475-6f4h3cck 92 19 and and CC cord-267475-6f4h3cck 92 20 p9 p9 NNP cord-267475-6f4h3cck 92 21 movement movement NN cord-267475-6f4h3cck 92 22 proteins protein NNS cord-267475-6f4h3cck 93 1 Internal internal JJ cord-267475-6f4h3cck 93 2 promoters promoter NNS cord-267475-6f4h3cck 94 1 Li Li NNP cord-267475-6f4h3cck 94 2 et et NNP cord-267475-6f4h3cck 94 3 al al NNP cord-267475-6f4h3cck 94 4 . . NNP cord-267475-6f4h3cck 94 5 , , , cord-267475-6f4h3cck 94 6 1998 1998 CD cord-267475-6f4h3cck 94 7 ; ; : cord-267475-6f4h3cck 94 8 Wang Wang NNP cord-267475-6f4h3cck 94 9 and and CC cord-267475-6f4h3cck 94 10 Simon Simon NNP cord-267475-6f4h3cck 94 11 , , , cord-267475-6f4h3cck 94 12 1997 1997 CD cord-267475-6f4h3cck 94 13 Fütterer Fütterer NNP cord-267475-6f4h3cck 94 14 et et NNP cord-267475-6f4h3cck 94 15 al al NNP cord-267475-6f4h3cck 94 16 . . . cord-267475-6f4h3cck 95 1 , , , cord-267475-6f4h3cck 95 2 1994 1994 CD cord-267475-6f4h3cck 95 3 a a DT cord-267475-6f4h3cck 95 4 The the DT cord-267475-6f4h3cck 95 5 silent silent JJ cord-267475-6f4h3cck 95 6 downstream downstream NN cord-267475-6f4h3cck 95 7 cistron cistron NN cord-267475-6f4h3cck 95 8 identified identify VBN cord-267475-6f4h3cck 95 9 in in IN cord-267475-6f4h3cck 95 10 the the DT cord-267475-6f4h3cck 95 11 third third JJ cord-267475-6f4h3cck 95 12 column column NN cord-267475-6f4h3cck 95 13 is be VBZ cord-267475-6f4h3cck 95 14 expressed express VBN cord-267475-6f4h3cck 95 15 only only RB cord-267475-6f4h3cck 95 16 upon upon IN cord-267475-6f4h3cck 95 17 being be VBG cord-267475-6f4h3cck 95 18 moved move VBN cord-267475-6f4h3cck 95 19 closer close RBR cord-267475-6f4h3cck 95 20 to to IN cord-267475-6f4h3cck 95 21 the the DT cord-267475-6f4h3cck 95 22 5 5 CD cord-267475-6f4h3cck 95 23 0 0 CD cord-267475-6f4h3cck 95 24 end end NN cord-267475-6f4h3cck 95 25 via via IN cord-267475-6f4h3cck 95 26 production production NN cord-267475-6f4h3cck 95 27 of of IN cord-267475-6f4h3cck 95 28 a a DT cord-267475-6f4h3cck 95 29 second second JJ cord-267475-6f4h3cck 95 30 , , , cord-267475-6f4h3cck 95 31 shorter short JJR cord-267475-6f4h3cck 95 32 mRNA mRNA NNP cord-267475-6f4h3cck 95 33 . . . cord-267475-6f4h3cck 96 1 Translation translation NN cord-267475-6f4h3cck 96 2 of of IN cord-267475-6f4h3cck 96 3 most most JJS cord-267475-6f4h3cck 96 4 genes gene NNS cord-267475-6f4h3cck 96 5 derived derive VBN cord-267475-6f4h3cck 96 6 from from IN cord-267475-6f4h3cck 96 7 these these DT cord-267475-6f4h3cck 96 8 viruses virus NNS cord-267475-6f4h3cck 96 9 follows follow VBZ cord-267475-6f4h3cck 96 10 straightforward straightforward JJ cord-267475-6f4h3cck 96 11 predictions prediction NNS cord-267475-6f4h3cck 96 12 of of IN cord-267475-6f4h3cck 96 13 the the DT cord-267475-6f4h3cck 96 14 scanning scanning NN cord-267475-6f4h3cck 96 15 mechanism mechanism NN cord-267475-6f4h3cck 96 16 , , , cord-267475-6f4h3cck 96 17 although although IN cord-267475-6f4h3cck 96 18 occasional occasional JJ cord-267475-6f4h3cck 96 19 deviations deviation NNS cord-267475-6f4h3cck 96 20 have have VBP cord-267475-6f4h3cck 96 21 been be VBN cord-267475-6f4h3cck 96 22 reported report VBN cord-267475-6f4h3cck 96 23 . . . cord-267475-6f4h3cck 97 1 In in IN cord-267475-6f4h3cck 97 2 rare rare JJ cord-267475-6f4h3cck 97 3 instances instance NNS cord-267475-6f4h3cck 97 4 where where WRB cord-267475-6f4h3cck 97 5 a a DT cord-267475-6f4h3cck 97 6 3 3 CD cord-267475-6f4h3cck 97 7 0 0 CD cord-267475-6f4h3cck 97 8 cistron cistron NN cord-267475-6f4h3cck 97 9 appears appear VBZ cord-267475-6f4h3cck 97 10 to to TO cord-267475-6f4h3cck 97 11 be be VB cord-267475-6f4h3cck 97 12 translated translate VBN cord-267475-6f4h3cck 97 13 from from IN cord-267475-6f4h3cck 97 14 a a DT cord-267475-6f4h3cck 97 15 dicistronic dicistronic JJ cord-267475-6f4h3cck 98 1 mRNA mRNA NNP cord-267475-6f4h3cck 99 1 ( ( -LRB- cord-267475-6f4h3cck 99 2 Grundhoff Grundhoff NNP cord-267475-6f4h3cck 99 3 and and CC cord-267475-6f4h3cck 99 4 Ganem Ganem NNP cord-267475-6f4h3cck 99 5 , , , cord-267475-6f4h3cck 99 6 2001 2001 CD cord-267475-6f4h3cck 99 7 ; ; : cord-267475-6f4h3cck 99 8 Kirshner Kirshner NNP cord-267475-6f4h3cck 99 9 et et NNP cord-267475-6f4h3cck 99 10 al al NNP cord-267475-6f4h3cck 99 11 . . NNP cord-267475-6f4h3cck 99 12 , , , cord-267475-6f4h3cck 99 13 1999 1999 CD cord-267475-6f4h3cck 99 14 ; ; : cord-267475-6f4h3cck 99 15 Nador Nador NNP cord-267475-6f4h3cck 99 16 et et NNP cord-267475-6f4h3cck 99 17 al al NNP cord-267475-6f4h3cck 99 18 . . NNP cord-267475-6f4h3cck 99 19 , , , cord-267475-6f4h3cck 99 20 2001 2001 CD cord-267475-6f4h3cck 100 1 ; ; : cord-267475-6f4h3cck 100 2 Stacey Stacey NNP cord-267475-6f4h3cck 100 3 et et NNP cord-267475-6f4h3cck 100 4 al al NNP cord-267475-6f4h3cck 100 5 . . NNP cord-267475-6f4h3cck 100 6 , , , cord-267475-6f4h3cck 100 7 2000 2000 CD cord-267475-6f4h3cck 100 8 ) ) -RRB- cord-267475-6f4h3cck 100 9 , , , cord-267475-6f4h3cck 100 10 the the DT cord-267475-6f4h3cck 100 11 virus virus NN cord-267475-6f4h3cck 100 12 in in IN cord-267475-6f4h3cck 100 13 question question NN cord-267475-6f4h3cck 100 14 employs employ VBZ cord-267475-6f4h3cck 100 15 a a DT cord-267475-6f4h3cck 100 16 complicated complicated JJ cord-267475-6f4h3cck 100 17 pattern pattern NN cord-267475-6f4h3cck 100 18 of of IN cord-267475-6f4h3cck 100 19 splicing splicing NN cord-267475-6f4h3cck 100 20 and and CC cord-267475-6f4h3cck 101 1 therefore therefore RB cord-267475-6f4h3cck 101 2 the the DT cord-267475-6f4h3cck 101 3 existence existence NN cord-267475-6f4h3cck 101 4 of of IN cord-267475-6f4h3cck 101 5 an an DT cord-267475-6f4h3cck 101 6 undetected undetected JJ cord-267475-6f4h3cck 101 7 monocistronic monocistronic NN cord-267475-6f4h3cck 101 8 mRNA mRNA NNP cord-267475-6f4h3cck 101 9 is be VBZ cord-267475-6f4h3cck 101 10 not not RB cord-267475-6f4h3cck 101 11 beyond beyond IN cord-267475-6f4h3cck 101 12 the the DT cord-267475-6f4h3cck 101 13 realm realm NN cord-267475-6f4h3cck 101 14 of of IN cord-267475-6f4h3cck 101 15 reason reason NN cord-267475-6f4h3cck 101 16 . . . cord-267475-6f4h3cck 102 1 In in IN cord-267475-6f4h3cck 102 2 some some DT cord-267475-6f4h3cck 102 3 other other JJ cord-267475-6f4h3cck 102 4 cases case NNS cord-267475-6f4h3cck 102 5 only only RB cord-267475-6f4h3cck 102 6 a a DT cord-267475-6f4h3cck 102 7 small small JJ cord-267475-6f4h3cck 102 8 amount amount NN cord-267475-6f4h3cck 102 9 of of IN cord-267475-6f4h3cck 102 10 the the DT cord-267475-6f4h3cck 102 11 protein protein NN cord-267475-6f4h3cck 102 12 encoded encode VBN cord-267475-6f4h3cck 102 13 by by IN cord-267475-6f4h3cck 102 14 the the DT cord-267475-6f4h3cck 102 15 3 3 CD cord-267475-6f4h3cck 102 16 0 0 CD cord-267475-6f4h3cck 102 17 cistron cistron NN cord-267475-6f4h3cck 102 18 was be VBD cord-267475-6f4h3cck 102 19 produced produce VBN cord-267475-6f4h3cck 102 20 , , , cord-267475-6f4h3cck 102 21 and and CC cord-267475-6f4h3cck 102 22 the the DT cord-267475-6f4h3cck 102 23 published publish VBN cord-267475-6f4h3cck 102 24 RNA RNA NNP cord-267475-6f4h3cck 102 25 analyses analysis NNS cord-267475-6f4h3cck 102 26 were be VBD cord-267475-6f4h3cck 102 27 not not RB cord-267475-6f4h3cck 102 28 sufficiently sufficiently RB cord-267475-6f4h3cck 102 29 sensitive sensitive JJ cord-267475-6f4h3cck 102 30 to to TO cord-267475-6f4h3cck 102 31 rule rule VB cord-267475-6f4h3cck 102 32 out out RP cord-267475-6f4h3cck 102 33 the the DT cord-267475-6f4h3cck 102 34 presence presence NN cord-267475-6f4h3cck 102 35 of of IN cord-267475-6f4h3cck 102 36 an an DT cord-267475-6f4h3cck 102 37 additional additional JJ cord-267475-6f4h3cck 102 38 subgenomic subgenomic NN cord-267475-6f4h3cck 102 39 mRNA mrna NN cord-267475-6f4h3cck 103 1 ( ( -LRB- cord-267475-6f4h3cck 103 2 Herbert Herbert NNP cord-267475-6f4h3cck 103 3 et et NNP cord-267475-6f4h3cck 103 4 al al NNP cord-267475-6f4h3cck 103 5 . . NNP cord-267475-6f4h3cck 103 6 , , , cord-267475-6f4h3cck 103 7 1996 1996 CD cord-267475-6f4h3cck 103 8 ) ) -RRB- cord-267475-6f4h3cck 103 9 . . . cord-267475-6f4h3cck 104 1 b b LS cord-267475-6f4h3cck 104 2 In in IN cord-267475-6f4h3cck 104 3 some some DT cord-267475-6f4h3cck 104 4 cases case NNS cord-267475-6f4h3cck 104 5 the the DT cord-267475-6f4h3cck 104 6 listed list VBN cord-267475-6f4h3cck 104 7 example example NN cord-267475-6f4h3cck 104 8 is be VBZ cord-267475-6f4h3cck 104 9 arbitrary arbitrary JJ cord-267475-6f4h3cck 104 10 , , , cord-267475-6f4h3cck 104 11 i.e. i.e. FW cord-267475-6f4h3cck 104 12 with with IN cord-267475-6f4h3cck 104 13 retroviruses retrovirus NNS cord-267475-6f4h3cck 104 14 , , , cord-267475-6f4h3cck 104 15 coronaviruses coronaviruse NNS cord-267475-6f4h3cck 104 16 , , , cord-267475-6f4h3cck 104 17 closteroviruses closteroviruse NNS cord-267475-6f4h3cck 104 18 , , , cord-267475-6f4h3cck 104 19 etc etc FW cord-267475-6f4h3cck 104 20 . . . cord-267475-6f4h3cck 105 1 , , , cord-267475-6f4h3cck 105 2 there there EX cord-267475-6f4h3cck 105 3 are be VBP cord-267475-6f4h3cck 105 4 additional additional JJ cord-267475-6f4h3cck 105 5 polycistronic polycistronic NNS cord-267475-6f4h3cck 105 6 mRNAs mrnas XX cord-267475-6f4h3cck 105 7 wherein wherein WRB cord-267475-6f4h3cck 105 8 translation translation NN cord-267475-6f4h3cck 105 9 is be VBZ cord-267475-6f4h3cck 105 10 restricted restrict VBN cord-267475-6f4h3cck 105 11 to to IN cord-267475-6f4h3cck 105 12 the the DT cord-267475-6f4h3cck 105 13 5 5 CD cord-267475-6f4h3cck 105 14 0 0 CD cord-267475-6f4h3cck 105 15 cistron cistron NN cord-267475-6f4h3cck 105 16 . . . cord-267475-6f4h3cck 106 1 c c NNP cord-267475-6f4h3cck 107 1 Whereas whereas IN cord-267475-6f4h3cck 107 2 DNA dna NN cord-267475-6f4h3cck 107 3 viruses virus NNS cord-267475-6f4h3cck 107 4 and and CC cord-267475-6f4h3cck 107 5 retroviruses retrovirus NNS cord-267475-6f4h3cck 107 6 use use VBP cord-267475-6f4h3cck 107 7 conventional conventional JJ cord-267475-6f4h3cck 107 8 promoter promoter NN cord-267475-6f4h3cck 107 9 - - HYPH cord-267475-6f4h3cck 107 10 switching switching NN cord-267475-6f4h3cck 107 11 or or CC cord-267475-6f4h3cck 107 12 splicing splicing NN cord-267475-6f4h3cck 107 13 mechanisms mechanism NNS cord-267475-6f4h3cck 107 14 to to TO cord-267475-6f4h3cck 107 15 generate generate VB cord-267475-6f4h3cck 107 16 alternative alternative JJ cord-267475-6f4h3cck 107 17 forms form NNS cord-267475-6f4h3cck 107 18 of of IN cord-267475-6f4h3cck 107 19 mRNA mrna NN cord-267475-6f4h3cck 107 20 that that WDT cord-267475-6f4h3cck 107 21 allow allow VBP cord-267475-6f4h3cck 107 22 translation translation NN cord-267475-6f4h3cck 107 23 of of IN cord-267475-6f4h3cck 107 24 the the DT cord-267475-6f4h3cck 107 25 downstream downstream JJ cord-267475-6f4h3cck 107 26 cistron cistron NN cord-267475-6f4h3cck 107 27 , , , cord-267475-6f4h3cck 107 28 more more RBR cord-267475-6f4h3cck 107 29 complicated complicated JJ cord-267475-6f4h3cck 107 30 mechanisms mechanism NNS cord-267475-6f4h3cck 107 31 underlie underlie VBP cord-267475-6f4h3cck 107 32 the the DT cord-267475-6f4h3cck 107 33 production production NN cord-267475-6f4h3cck 107 34 of of IN cord-267475-6f4h3cck 107 35 subgenomic subgenomic NNP cord-267475-6f4h3cck 107 36 mRNAs mRNAs NNPS cord-267475-6f4h3cck 107 37 by by IN cord-267475-6f4h3cck 107 38 some some DT cord-267475-6f4h3cck 107 39 RNA RNA NNP cord-267475-6f4h3cck 107 40 viruses virus NNS cord-267475-6f4h3cck 107 41 . . . cord-267475-6f4h3cck 108 1 d d LS cord-267475-6f4h3cck 108 2 The the DT cord-267475-6f4h3cck 108 3 presence presence NN cord-267475-6f4h3cck 108 4 of of IN cord-267475-6f4h3cck 108 5 internal internal JJ cord-267475-6f4h3cck 108 6 promoters promoter NNS cord-267475-6f4h3cck 108 7 that that WDT cord-267475-6f4h3cck 108 8 produce produce VBP cord-267475-6f4h3cck 108 9 a a DT cord-267475-6f4h3cck 108 10 shorter short JJR cord-267475-6f4h3cck 108 11 transcript transcript NN cord-267475-6f4h3cck 108 12 for for IN cord-267475-6f4h3cck 108 13 each each DT cord-267475-6f4h3cck 108 14 downstream downstream JJ cord-267475-6f4h3cck 108 15 ORF ORF NNP cord-267475-6f4h3cck 108 16 is be VBZ cord-267475-6f4h3cck 108 17 suggestive suggestive JJ cord-267475-6f4h3cck 108 18 , , , cord-267475-6f4h3cck 108 19 but but CC cord-267475-6f4h3cck 108 20 testing testing NN cord-267475-6f4h3cck 108 21 of of IN cord-267475-6f4h3cck 108 22 translation translation NN cord-267475-6f4h3cck 108 23 is be VBZ cord-267475-6f4h3cck 108 24 still still RB cord-267475-6f4h3cck 108 25 needed need VBN cord-267475-6f4h3cck 108 26 for for IN cord-267475-6f4h3cck 108 27 the the DT cord-267475-6f4h3cck 108 28 mRNAs mRNAs NNPS cord-267475-6f4h3cck 108 29 produced produce VBN cord-267475-6f4h3cck 108 30 by by IN cord-267475-6f4h3cck 108 31 cytomegalovirus cytomegalovirus NNP cord-267475-6f4h3cck 108 32 and and CC cord-267475-6f4h3cck 108 33 geminivirus geminivirus NNP cord-267475-6f4h3cck 108 34 . . . cord-267475-6f4h3cck 109 1 e e LS cord-267475-6f4h3cck 110 1 Whereas whereas IN cord-267475-6f4h3cck 110 2 all all DT cord-267475-6f4h3cck 110 3 retroviruses retrovirus NNS cord-267475-6f4h3cck 110 4 employ employ VBP cord-267475-6f4h3cck 110 5 splicing splicing NN cord-267475-6f4h3cck 110 6 to to TO cord-267475-6f4h3cck 110 7 produce produce VB cord-267475-6f4h3cck 110 8 the the DT cord-267475-6f4h3cck 110 9 subgenomic subgenomic NNP cord-267475-6f4h3cck 110 10 mRNA mrna NN cord-267475-6f4h3cck 110 11 from from IN cord-267475-6f4h3cck 110 12 which which WDT cord-267475-6f4h3cck 110 13 envelope envelope NN cord-267475-6f4h3cck 110 14 protein protein NN cord-267475-6f4h3cck 110 15 ( ( -LRB- cord-267475-6f4h3cck 110 16 Env Env NNP cord-267475-6f4h3cck 110 17 ) ) -RRB- cord-267475-6f4h3cck 110 18 is be VBZ cord-267475-6f4h3cck 110 19 translated translate VBN cord-267475-6f4h3cck 110 20 , , , cord-267475-6f4h3cck 110 21 some some DT cord-267475-6f4h3cck 110 22 retroviruses retrovirus NNS cord-267475-6f4h3cck 110 23 also also RB cord-267475-6f4h3cck 110 24 employ employ VBP cord-267475-6f4h3cck 110 25 an an DT cord-267475-6f4h3cck 110 26 internal internal JJ cord-267475-6f4h3cck 110 27 promoter promoter NN cord-267475-6f4h3cck 110 28 which which WDT cord-267475-6f4h3cck 110 29 is be VBZ cord-267475-6f4h3cck 110 30 postulated postulate VBN cord-267475-6f4h3cck 110 31 to to TO cord-267475-6f4h3cck 110 32 mediate mediate VB cord-267475-6f4h3cck 110 33 expression expression NN cord-267475-6f4h3cck 110 34 of of IN cord-267475-6f4h3cck 110 35 novel novel NN cord-267475-6f4h3cck 110 36 ORFs orf NNS cord-267475-6f4h3cck 110 37 , , , cord-267475-6f4h3cck 110 38 such such JJ cord-267475-6f4h3cck 110 39 as as IN cord-267475-6f4h3cck 110 40 the the DT cord-267475-6f4h3cck 110 41 superantigen superantigen NN cord-267475-6f4h3cck 110 42 of of IN cord-267475-6f4h3cck 110 43 mouse mouse NN cord-267475-6f4h3cck 110 44 mammary mammary JJ cord-267475-6f4h3cck 110 45 tumor tumor NN cord-267475-6f4h3cck 110 46 virus virus NN cord-267475-6f4h3cck 110 47 ( ( -LRB- cord-267475-6f4h3cck 110 48 Reuss Reuss NNP cord-267475-6f4h3cck 110 49 and and CC cord-267475-6f4h3cck 110 50 Coffin Coffin NNP cord-267475-6f4h3cck 110 51 , , , cord-267475-6f4h3cck 110 52 1998 1998 CD cord-267475-6f4h3cck 110 53 ) ) -RRB- cord-267475-6f4h3cck 110 54 and and CC cord-267475-6f4h3cck 110 55 orf orf NNP cord-267475-6f4h3cck 110 56 - - HYPH cord-267475-6f4h3cck 110 57 x x SYM cord-267475-6f4h3cck 110 58 of of IN cord-267475-6f4h3cck 110 59 the the DT cord-267475-6f4h3cck 110 60 virus virus NN cord-267475-6f4h3cck 110 61 that that WDT cord-267475-6f4h3cck 110 62 causes cause VBZ cord-267475-6f4h3cck 110 63 lung lung NN cord-267475-6f4h3cck 110 64 cancer cancer NN cord-267475-6f4h3cck 110 65 in in IN cord-267475-6f4h3cck 110 66 sheep sheep NN cord-267475-6f4h3cck 110 67 ( ( -LRB- cord-267475-6f4h3cck 110 68 Palmarini Palmarini NNP cord-267475-6f4h3cck 110 69 et et NNP cord-267475-6f4h3cck 110 70 al al NNP cord-267475-6f4h3cck 110 71 . . NNP cord-267475-6f4h3cck 110 72 , , , cord-267475-6f4h3cck 110 73 2002 2002 CD cord-267475-6f4h3cck 110 74 ) ) -RRB- cord-267475-6f4h3cck 110 75 . . . cord-267475-6f4h3cck 111 1 f f LS cord-267475-6f4h3cck 111 2 See see VB cord-267475-6f4h3cck 111 3 leaky leaky JJ cord-267475-6f4h3cck 111 4 scanning scanning NN cord-267475-6f4h3cck 111 5 in in IN cord-267475-6f4h3cck 111 6 Table Table NNP cord-267475-6f4h3cck 111 7 3 3 CD cord-267475-6f4h3cck 111 8 and and CC cord-267475-6f4h3cck 111 9 Fig Fig NNP cord-267475-6f4h3cck 111 10 . . . cord-267475-6f4h3cck 112 1 1 1 LS cord-267475-6f4h3cck 112 2 . . . cord-267475-6f4h3cck 113 1 g g NNP cord-267475-6f4h3cck 114 1 In in IN cord-267475-6f4h3cck 114 2 place place NN cord-267475-6f4h3cck 114 3 of of IN cord-267475-6f4h3cck 114 4 the the DT cord-267475-6f4h3cck 114 5 usual usual JJ cord-267475-6f4h3cck 114 6 m7 m7 NN cord-267475-6f4h3cck 114 7 G g NN cord-267475-6f4h3cck 114 8 cap cap NN cord-267475-6f4h3cck 114 9 , , , cord-267475-6f4h3cck 114 10 the the DT cord-267475-6f4h3cck 114 11 5 5 CD cord-267475-6f4h3cck 114 12 0 0 CD cord-267475-6f4h3cck 114 13 end end NN cord-267475-6f4h3cck 114 14 of of IN cord-267475-6f4h3cck 114 15 these these DT cord-267475-6f4h3cck 114 16 viral viral JJ cord-267475-6f4h3cck 114 17 RNAs rna NNS cord-267475-6f4h3cck 114 18 carries carry VBZ cord-267475-6f4h3cck 114 19 a a DT cord-267475-6f4h3cck 114 20 covalently covalently RB cord-267475-6f4h3cck 114 21 linked link VBN cord-267475-6f4h3cck 114 22 protein protein NN cord-267475-6f4h3cck 114 23 ( ( -LRB- cord-267475-6f4h3cck 114 24 VPg VPg NNS cord-267475-6f4h3cck 114 25 ) ) -RRB- cord-267475-6f4h3cck 114 26 or or CC cord-267475-6f4h3cck 114 27 is be VBZ cord-267475-6f4h3cck 114 28 unblocked unblocked JJ cord-267475-6f4h3cck 114 29 . . . cord-267475-6f4h3cck 115 1 The the DT cord-267475-6f4h3cck 115 2 need need NN cord-267475-6f4h3cck 115 3 for for IN cord-267475-6f4h3cck 115 4 a a DT cord-267475-6f4h3cck 115 5 subgenomic subgenomic NNP cord-267475-6f4h3cck 115 6 mRNA mrna NN cord-267475-6f4h3cck 115 7 even even RB cord-267475-6f4h3cck 115 8 in in IN cord-267475-6f4h3cck 115 9 these these DT cord-267475-6f4h3cck 115 10 cases case NNS cord-267475-6f4h3cck 115 11 emphasizes emphasize VBZ cord-267475-6f4h3cck 115 12 that that DT cord-267475-6f4h3cck 115 13 translation translation NN cord-267475-6f4h3cck 115 14 is be VBZ cord-267475-6f4h3cck 115 15 5 5 CD cord-267475-6f4h3cck 115 16 0 0 CD cord-267475-6f4h3cck 115 17 end end NN cord-267475-6f4h3cck 115 18 - - HYPH cord-267475-6f4h3cck 115 19 dependent dependent JJ cord-267475-6f4h3cck 115 20 even even RB cord-267475-6f4h3cck 115 21 when when WRB cord-267475-6f4h3cck 115 22 it -PRON- PRP cord-267475-6f4h3cck 115 23 is be VBZ cord-267475-6f4h3cck 115 24 not not RB cord-267475-6f4h3cck 115 25 cap cap NN cord-267475-6f4h3cck 115 26 - - HYPH cord-267475-6f4h3cck 115 27 dependent dependent JJ cord-267475-6f4h3cck 115 28 . . . cord-267475-6f4h3cck 116 1 h h NNP cord-267475-6f4h3cck 117 1 The the DT cord-267475-6f4h3cck 117 2 full full JJ cord-267475-6f4h3cck 117 3 - - HYPH cord-267475-6f4h3cck 117 4 length length NN cord-267475-6f4h3cck 117 5 genomic genomic JJ cord-267475-6f4h3cck 117 6 mRNA mrna NN cord-267475-6f4h3cck 117 7 supports support VBZ cord-267475-6f4h3cck 117 8 translation translation NN cord-267475-6f4h3cck 117 9 of of IN cord-267475-6f4h3cck 117 10 the the DT cord-267475-6f4h3cck 117 11 3 3 CD cord-267475-6f4h3cck 117 12 0 0 CD cord-267475-6f4h3cck 117 13 cistron cistron NN cord-267475-6f4h3cck 117 14 in in IN cord-267475-6f4h3cck 117 15 vitro vitro FW cord-267475-6f4h3cck 117 16 but but CC cord-267475-6f4h3cck 117 17 the the DT cord-267475-6f4h3cck 117 18 3 3 CD cord-267475-6f4h3cck 117 19 0 0 CD cord-267475-6f4h3cck 117 20 cistron cistron NN cord-267475-6f4h3cck 117 21 is be VBZ cord-267475-6f4h3cck 117 22 silent silent JJ cord-267475-6f4h3cck 117 23 in in IN cord-267475-6f4h3cck 117 24 vivo vivo NN cord-267475-6f4h3cck 117 25 . . . cord-267475-6f4h3cck 118 1 The the DT cord-267475-6f4h3cck 118 2 latter latter JJ cord-267475-6f4h3cck 118 3 result result NN cord-267475-6f4h3cck 118 4 is be VBZ cord-267475-6f4h3cck 118 5 considered consider VBN cord-267475-6f4h3cck 118 6 more more RBR cord-267475-6f4h3cck 118 7 reliable reliable JJ cord-267475-6f4h3cck 118 8 ( ( -LRB- cord-267475-6f4h3cck 119 1 Meulewaeter Meulewaeter NNP cord-267475-6f4h3cck 119 2 et et NNP cord-267475-6f4h3cck 119 3 al al NNP cord-267475-6f4h3cck 119 4 . . NNP cord-267475-6f4h3cck 119 5 , , , cord-267475-6f4h3cck 119 6 1992 1992 CD cord-267475-6f4h3cck 119 7 ) ) -RRB- cord-267475-6f4h3cck 119 8 . . . cord-267475-6f4h3cck 120 1 Notwithstanding notwithstanding IN cord-267475-6f4h3cck 120 2 the the DT cord-267475-6f4h3cck 120 3 documented document VBN cord-267475-6f4h3cck 120 4 inability inability NN cord-267475-6f4h3cck 120 5 to to TO cord-267475-6f4h3cck 120 6 translate translate VB cord-267475-6f4h3cck 120 7 the the DT cord-267475-6f4h3cck 120 8 3 3 CD cord-267475-6f4h3cck 120 9 0 0 CD cord-267475-6f4h3cck 120 10 cistron cistron NN cord-267475-6f4h3cck 120 11 in in IN cord-267475-6f4h3cck 120 12 natural natural JJ cord-267475-6f4h3cck 120 13 dicistronic dicistronic NNP cord-267475-6f4h3cck 120 14 mRNAs mRNAs NNPS cord-267475-6f4h3cck 120 15 , , , cord-267475-6f4h3cck 120 16 synthetic synthetic JJ cord-267475-6f4h3cck 120 17 dicistronic dicistronic NNP cord-267475-6f4h3cck 120 18 mRNAs mrnas CD cord-267475-6f4h3cck 120 19 -constructed -constructe VBN cord-267475-6f4h3cck 120 20 by by IN cord-267475-6f4h3cck 120 21 inserting insert VBG cord-267475-6f4h3cck 120 22 a a DT cord-267475-6f4h3cck 120 23 putative putative JJ cord-267475-6f4h3cck 120 24 IRES IRES NNP cord-267475-6f4h3cck 120 25 element element NN cord-267475-6f4h3cck 120 26 between between IN cord-267475-6f4h3cck 120 27 two two CD cord-267475-6f4h3cck 120 28 reporter reporter NN cord-267475-6f4h3cck 120 29 genes gene NNS cord-267475-6f4h3cck 121 1 -appear -appear JJ cord-267475-6f4h3cck 122 1 sometimes sometimes RB cord-267475-6f4h3cck 122 2 to to TO cord-267475-6f4h3cck 122 3 allow allow VB cord-267475-6f4h3cck 122 4 translation translation NN cord-267475-6f4h3cck 122 5 of of IN cord-267475-6f4h3cck 122 6 the the DT cord-267475-6f4h3cck 122 7 downstream downstream JJ cord-267475-6f4h3cck 122 8 cistron cistron NN cord-267475-6f4h3cck 122 9 . . . cord-267475-6f4h3cck 123 1 The the DT cord-267475-6f4h3cck 123 2 interpretation interpretation NN cord-267475-6f4h3cck 123 3 that that IN cord-267475-6f4h3cck 123 4 this this DT cord-267475-6f4h3cck 123 5 occurs occur VBZ cord-267475-6f4h3cck 123 6 via via IN cord-267475-6f4h3cck 123 7 direct direct JJ cord-267475-6f4h3cck 123 8 internal internal JJ cord-267475-6f4h3cck 123 9 initiation initiation NN cord-267475-6f4h3cck 123 10 of of IN cord-267475-6f4h3cck 123 11 translation translation NN cord-267475-6f4h3cck 123 12 has have VBZ cord-267475-6f4h3cck 123 13 been be VBN cord-267475-6f4h3cck 123 14 questioned question VBN cord-267475-6f4h3cck 123 15 ( ( -LRB- cord-267475-6f4h3cck 123 16 Kozak Kozak NNP cord-267475-6f4h3cck 123 17 , , , cord-267475-6f4h3cck 123 18 2001a 2001a CD cord-267475-6f4h3cck 123 19 ) ) -RRB- cord-267475-6f4h3cck 123 20 and and CC cord-267475-6f4h3cck 123 21 defended defend VBD cord-267475-6f4h3cck 123 22 ( ( -LRB- cord-267475-6f4h3cck 123 23 Hellen Hellen NNP cord-267475-6f4h3cck 123 24 and and CC cord-267475-6f4h3cck 123 25 Sarnow Sarnow NNP cord-267475-6f4h3cck 123 26 , , , cord-267475-6f4h3cck 123 27 2001 2001 CD cord-267475-6f4h3cck 123 28 ) ) -RRB- cord-267475-6f4h3cck 123 29 in in IN cord-267475-6f4h3cck 123 30 other other JJ cord-267475-6f4h3cck 123 31 reviews review NNS cord-267475-6f4h3cck 123 32 . . . cord-267475-6f4h3cck 124 1 The the DT cord-267475-6f4h3cck 124 2 position position NN cord-267475-6f4h3cck 124 3 effect effect NN cord-267475-6f4h3cck 124 4 , , , cord-267475-6f4h3cck 124 5 indicative indicative JJ cord-267475-6f4h3cck 124 6 of of IN cord-267475-6f4h3cck 124 7 scanning scanning NN cord-267475-6f4h3cck 124 8 , , , cord-267475-6f4h3cck 124 9 is be VBZ cord-267475-6f4h3cck 124 10 seen see VBN cord-267475-6f4h3cck 124 11 when when WRB cord-267475-6f4h3cck 124 12 a a DT cord-267475-6f4h3cck 124 13 mutation mutation NN cord-267475-6f4h3cck 124 14 creates create VBZ cord-267475-6f4h3cck 124 15 an an DT cord-267475-6f4h3cck 124 16 AUG AUG NNP cord-267475-6f4h3cck 124 17 codon codon NN cord-267475-6f4h3cck 124 18 upstream upstream RB cord-267475-6f4h3cck 124 19 from from IN cord-267475-6f4h3cck 124 20 the the DT cord-267475-6f4h3cck 124 21 normal normal JJ cord-267475-6f4h3cck 124 22 start start NN cord-267475-6f4h3cck 124 23 codon codon NN cord-267475-6f4h3cck 124 24 and and CC cord-267475-6f4h3cck 124 25 translation translation NN cord-267475-6f4h3cck 124 26 shifts shift NNS cord-267475-6f4h3cck 124 27 to to IN cord-267475-6f4h3cck 124 28 the the DT cord-267475-6f4h3cck 124 29 upstream upstream JJ cord-267475-6f4h3cck 124 30 site site NN cord-267475-6f4h3cck 124 31 ( ( -LRB- cord-267475-6f4h3cck 124 32 Bergenhem Bergenhem NNP cord-267475-6f4h3cck 124 33 et et NNP cord-267475-6f4h3cck 124 34 al al NNP cord-267475-6f4h3cck 124 35 . . NNP cord-267475-6f4h3cck 124 36 , , , cord-267475-6f4h3cck 124 37 1992 1992 CD cord-267475-6f4h3cck 124 38 ; ; : cord-267475-6f4h3cck 124 39 Cai Cai NNP cord-267475-6f4h3cck 124 40 et et FW cord-267475-6f4h3cck 124 41 al al NNP cord-267475-6f4h3cck 124 42 . . NNP cord-267475-6f4h3cck 124 43 , , , cord-267475-6f4h3cck 124 44 1992 1992 CD cord-267475-6f4h3cck 124 45 ; ; : cord-267475-6f4h3cck 124 46 Gross Gross NNP cord-267475-6f4h3cck 124 47 et et FW cord-267475-6f4h3cck 124 48 al al NNP cord-267475-6f4h3cck 124 49 . . NNP cord-267475-6f4h3cck 124 50 , , , cord-267475-6f4h3cck 124 51 1998 1998 CD cord-267475-6f4h3cck 124 52 ; ; : cord-267475-6f4h3cck 124 53 Harington Harington NNP cord-267475-6f4h3cck 124 54 et et NNP cord-267475-6f4h3cck 124 55 al al NNP cord-267475-6f4h3cck 124 56 . . NNP cord-267475-6f4h3cck 124 57 , , , cord-267475-6f4h3cck 124 58 1994 1994 CD cord-267475-6f4h3cck 124 59 ; ; : cord-267475-6f4h3cck 124 60 Liu Liu NNP cord-267475-6f4h3cck 124 61 et et NNP cord-267475-6f4h3cck 124 62 al al NNP cord-267475-6f4h3cck 124 63 . . NNP cord-267475-6f4h3cck 124 64 , , , cord-267475-6f4h3cck 124 65 1999 1999 CD cord-267475-6f4h3cck 124 66 ; ; : cord-267475-6f4h3cck 124 67 Lock Lock NNP cord-267475-6f4h3cck 124 68 et et FW cord-267475-6f4h3cck 124 69 al al NNP cord-267475-6f4h3cck 124 70 . . NNP cord-267475-6f4h3cck 124 71 , , , cord-267475-6f4h3cck 124 72 1991 1991 CD cord-267475-6f4h3cck 124 73 ; ; : cord-267475-6f4h3cck 124 74 Mével Mével NNP cord-267475-6f4h3cck 124 75 - - HYPH cord-267475-6f4h3cck 124 76 Ninio Ninio NNP cord-267475-6f4h3cck 124 77 et et NNP cord-267475-6f4h3cck 124 78 al al NNP cord-267475-6f4h3cck 124 79 . . NNP cord-267475-6f4h3cck 124 80 , , , cord-267475-6f4h3cck 124 81 1996 1996 CD cord-267475-6f4h3cck 124 82 ; ; : cord-267475-6f4h3cck 124 83 Muralidhar Muralidhar NNP cord-267475-6f4h3cck 124 84 et et NNP cord-267475-6f4h3cck 124 85 al al NNP cord-267475-6f4h3cck 124 86 . . NNP cord-267475-6f4h3cck 124 87 , , , cord-267475-6f4h3cck 124 88 1994 1994 CD cord-267475-6f4h3cck 124 89 ; ; : cord-267475-6f4h3cck 124 90 Wada Wada NNP cord-267475-6f4h3cck 124 91 et et NNP cord-267475-6f4h3cck 124 92 al al NNP cord-267475-6f4h3cck 124 93 . . NNP cord-267475-6f4h3cck 124 94 , , , cord-267475-6f4h3cck 124 95 1995 1995 CD cord-267475-6f4h3cck 124 96 ) ) -RRB- cord-267475-6f4h3cck 124 97 . . . cord-267475-6f4h3cck 125 1 In in IN cord-267475-6f4h3cck 125 2 the the DT cord-267475-6f4h3cck 125 3 most most RBS cord-267475-6f4h3cck 125 4 stringent stringent JJ cord-267475-6f4h3cck 125 5 test test NN cord-267475-6f4h3cck 125 6 of of IN cord-267475-6f4h3cck 125 7 the the DT cord-267475-6f4h3cck 125 8 rule rule NN cord-267475-6f4h3cck 125 9 , , , cord-267475-6f4h3cck 125 10 the the DT cord-267475-6f4h3cck 125 11 first first JJ cord-267475-6f4h3cck 125 12 AUG AUG NNP cord-267475-6f4h3cck 125 13 codon codon NN cord-267475-6f4h3cck 125 14 was be VBD cord-267475-6f4h3cck 125 15 shown show VBN cord-267475-6f4h3cck 125 16 to to TO cord-267475-6f4h3cck 125 17 be be VB cord-267475-6f4h3cck 125 18 the the DT cord-267475-6f4h3cck 125 19 exclusive exclusive JJ cord-267475-6f4h3cck 125 20 site site NN cord-267475-6f4h3cck 125 21 of of IN cord-267475-6f4h3cck 125 22 initiation initiation NN cord-267475-6f4h3cck 125 23 even even RB cord-267475-6f4h3cck 125 24 when when WRB cord-267475-6f4h3cck 125 25 the the DT cord-267475-6f4h3cck 125 26 second second JJ cord-267475-6f4h3cck 125 27 AUG AUG NNP cord-267475-6f4h3cck 125 28 was be VBD cord-267475-6f4h3cck 125 29 positioned position VBN cord-267475-6f4h3cck 125 30 just just RB cord-267475-6f4h3cck 125 31 a a DT cord-267475-6f4h3cck 125 32 few few JJ cord-267475-6f4h3cck 125 33 bases basis NNS cord-267475-6f4h3cck 125 34 downstream downstream RB cord-267475-6f4h3cck 125 35 from from IN cord-267475-6f4h3cck 125 36 , , , cord-267475-6f4h3cck 125 37 and and CC cord-267475-6f4h3cck 125 38 in in IN cord-267475-6f4h3cck 125 39 the the DT cord-267475-6f4h3cck 125 40 same same JJ cord-267475-6f4h3cck 125 41 optimal optimal JJ cord-267475-6f4h3cck 125 42 context context NN cord-267475-6f4h3cck 125 43 as as IN cord-267475-6f4h3cck 125 44 , , , cord-267475-6f4h3cck 125 45 the the DT cord-267475-6f4h3cck 125 46 first first JJ cord-267475-6f4h3cck 125 47 ( ( -LRB- cord-267475-6f4h3cck 125 48 Kozak Kozak NNP cord-267475-6f4h3cck 125 49 , , , cord-267475-6f4h3cck 125 50 1995 1995 CD cord-267475-6f4h3cck 125 51 ) ) -RRB- cord-267475-6f4h3cck 125 52 . . . cord-267475-6f4h3cck 126 1 The the DT cord-267475-6f4h3cck 126 2 position position NN cord-267475-6f4h3cck 126 3 effect effect NN cord-267475-6f4h3cck 126 4 is be VBZ cord-267475-6f4h3cck 126 5 seen see VBN cord-267475-6f4h3cck 126 6 also also RB cord-267475-6f4h3cck 126 7 when when WRB cord-267475-6f4h3cck 126 8 removal removal NN cord-267475-6f4h3cck 126 9 of of IN cord-267475-6f4h3cck 126 10 the the DT cord-267475-6f4h3cck 126 11 first first JJ cord-267475-6f4h3cck 126 12 start start NN cord-267475-6f4h3cck 126 13 codon codon NN cord-267475-6f4h3cck 126 14 activates activate VBZ cord-267475-6f4h3cck 126 15 initiation initiation NN cord-267475-6f4h3cck 126 16 from from IN cord-267475-6f4h3cck 126 17 the the DT cord-267475-6f4h3cck 126 18 next next JJ cord-267475-6f4h3cck 126 19 AUG AUG NNP cord-267475-6f4h3cck 126 20 downstream downstream NN cord-267475-6f4h3cck 126 21 . . . cord-267475-6f4h3cck 127 1 Some some DT cord-267475-6f4h3cck 127 2 genes gene NNS cord-267475-6f4h3cck 127 3 require require VBP cord-267475-6f4h3cck 127 4 production production NN cord-267475-6f4h3cck 127 5 of of IN cord-267475-6f4h3cck 127 6 two two CD cord-267475-6f4h3cck 127 7 versions version NNS cord-267475-6f4h3cck 127 8 of of IN cord-267475-6f4h3cck 127 9 the the DT cord-267475-6f4h3cck 127 10 encoded encode VBN cord-267475-6f4h3cck 127 11 protein protein NN cord-267475-6f4h3cck 127 12 , , , cord-267475-6f4h3cck 127 13 wherein wherein WRB cord-267475-6f4h3cck 127 14 the the DT cord-267475-6f4h3cck 127 15 shorter short JJR cord-267475-6f4h3cck 127 16 version version NN cord-267475-6f4h3cck 127 17 , , , cord-267475-6f4h3cck 127 18 initiated initiate VBD cord-267475-6f4h3cck 127 19 from from IN cord-267475-6f4h3cck 127 20 an an DT cord-267475-6f4h3cck 127 21 internal internal JJ cord-267475-6f4h3cck 127 22 AUG AUG NNP cord-267475-6f4h3cck 127 23 codon codon NN cord-267475-6f4h3cck 127 24 , , , cord-267475-6f4h3cck 127 25 lacks lack VBZ cord-267475-6f4h3cck 127 26 the the DT cord-267475-6f4h3cck 127 27 N n CD cord-267475-6f4h3cck 127 28 - - HYPH cord-267475-6f4h3cck 127 29 terminal terminal NN cord-267475-6f4h3cck 127 30 domain domain NN cord-267475-6f4h3cck 127 31 of of IN cord-267475-6f4h3cck 127 32 the the DT cord-267475-6f4h3cck 127 33 longer long JJR cord-267475-6f4h3cck 127 34 isoform isoform NN cord-267475-6f4h3cck 127 35 . . . cord-267475-6f4h3cck 128 1 The the DT cord-267475-6f4h3cck 128 2 problem problem NN cord-267475-6f4h3cck 128 3 of of IN cord-267475-6f4h3cck 128 4 how how WRB cord-267475-6f4h3cck 128 5 ribosomes ribosome NNS cord-267475-6f4h3cck 128 6 can can MD cord-267475-6f4h3cck 128 7 gain gain VB cord-267475-6f4h3cck 128 8 access access NN cord-267475-6f4h3cck 128 9 to to IN cord-267475-6f4h3cck 128 10 an an DT cord-267475-6f4h3cck 128 11 internal internal JJ cord-267475-6f4h3cck 128 12 start start NN cord-267475-6f4h3cck 128 13 codon codon NN cord-267475-6f4h3cck 128 14 is be VBZ cord-267475-6f4h3cck 128 15 solved solve VBN cord-267475-6f4h3cck 128 16 by by IN cord-267475-6f4h3cck 128 17 producing produce VBG cord-267475-6f4h3cck 128 18 , , , cord-267475-6f4h3cck 128 19 via via IN cord-267475-6f4h3cck 128 20 splicing splicing NN cord-267475-6f4h3cck 128 21 or or CC cord-267475-6f4h3cck 128 22 a a DT cord-267475-6f4h3cck 128 23 downstream downstream JJ cord-267475-6f4h3cck 128 24 promoter promoter NN cord-267475-6f4h3cck 128 25 , , , cord-267475-6f4h3cck 128 26 a a DT cord-267475-6f4h3cck 128 27 second second JJ cord-267475-6f4h3cck 128 28 form form NN cord-267475-6f4h3cck 128 29 of of IN cord-267475-6f4h3cck 128 30 mRNA mrna NN cord-267475-6f4h3cck 128 31 from from IN cord-267475-6f4h3cck 128 32 which which WDT cord-267475-6f4h3cck 128 33 the the DT cord-267475-6f4h3cck 128 34 first first JJ cord-267475-6f4h3cck 128 35 AUG AUG NNP cord-267475-6f4h3cck 128 36 START START NNP cord-267475-6f4h3cck 128 37 codon codon NN cord-267475-6f4h3cck 128 38 has have VBZ cord-267475-6f4h3cck 128 39 been be VBN cord-267475-6f4h3cck 128 40 removed remove VBN cord-267475-6f4h3cck 128 41 . . . cord-267475-6f4h3cck 129 1 Table table NN cord-267475-6f4h3cck 129 2 2 2 CD cord-267475-6f4h3cck 129 3 lists list VBZ cord-267475-6f4h3cck 129 4 some some DT cord-267475-6f4h3cck 129 5 examples example NNS cord-267475-6f4h3cck 129 6 . . . cord-267475-6f4h3cck 130 1 The the DT cord-267475-6f4h3cck 130 2 N N NNP cord-267475-6f4h3cck 130 3 - - HYPH cord-267475-6f4h3cck 130 4 terminally terminally RB cord-267475-6f4h3cck 130 5 truncated truncate VBN cord-267475-6f4h3cck 130 6 isoform isoform NN cord-267475-6f4h3cck 130 7 thus thus RB cord-267475-6f4h3cck 130 8 produced produce VBN cord-267475-6f4h3cck 130 9 may may MD cord-267475-6f4h3cck 130 10 reside reside VB cord-267475-6f4h3cck 130 11 in in IN cord-267475-6f4h3cck 130 12 a a DT cord-267475-6f4h3cck 130 13 different different JJ cord-267475-6f4h3cck 130 14 cellular cellular JJ cord-267475-6f4h3cck 130 15 compartment compartment NN cord-267475-6f4h3cck 130 16 , , , cord-267475-6f4h3cck 130 17 or or CC cord-267475-6f4h3cck 130 18 may may MD cord-267475-6f4h3cck 130 19 function function VB cord-267475-6f4h3cck 130 20 as as IN cord-267475-6f4h3cck 130 21 an an DT cord-267475-6f4h3cck 130 22 antagonist antagonist NN cord-267475-6f4h3cck 130 23 to to IN cord-267475-6f4h3cck 130 24 the the DT cord-267475-6f4h3cck 130 25 full full JJ cord-267475-6f4h3cck 130 26 - - HYPH cord-267475-6f4h3cck 130 27 length length NN cord-267475-6f4h3cck 130 28 protein protein NN cord-267475-6f4h3cck 130 29 ( ( -LRB- cord-267475-6f4h3cck 130 30 as as IN cord-267475-6f4h3cck 130 31 seen see VBN cord-267475-6f4h3cck 130 32 with with IN cord-267475-6f4h3cck 130 33 various various JJ cord-267475-6f4h3cck 130 34 transcription transcription NN cord-267475-6f4h3cck 130 35 factors factor NNS cord-267475-6f4h3cck 130 36 listed list VBN cord-267475-6f4h3cck 130 37 in in IN cord-267475-6f4h3cck 130 38 Table Table NNP cord-267475-6f4h3cck 130 39 2 2 CD cord-267475-6f4h3cck 130 40 ) ) -RRB- cord-267475-6f4h3cck 130 41 , , , cord-267475-6f4h3cck 130 42 or or CC cord-267475-6f4h3cck 130 43 may may MD cord-267475-6f4h3cck 130 44 function function VB cord-267475-6f4h3cck 130 45 in in IN cord-267475-6f4h3cck 130 46 a a DT cord-267475-6f4h3cck 130 47 surprising surprising JJ cord-267475-6f4h3cck 130 48 way way NN cord-267475-6f4h3cck 130 49 . . . cord-267475-6f4h3cck 131 1 One one CD cord-267475-6f4h3cck 131 2 such such JJ cord-267475-6f4h3cck 131 3 surprise surprise NN cord-267475-6f4h3cck 131 4 was be VBD cord-267475-6f4h3cck 131 5 the the DT cord-267475-6f4h3cck 131 6 discovery discovery NN cord-267475-6f4h3cck 131 7 that that IN cord-267475-6f4h3cck 131 8 a a DT cord-267475-6f4h3cck 131 9 truncated truncated JJ cord-267475-6f4h3cck 131 10 form form NN cord-267475-6f4h3cck 131 11 of of IN cord-267475-6f4h3cck 131 12 tryptophanyl tryptophanyl NNP cord-267475-6f4h3cck 131 13 - - HYPH cord-267475-6f4h3cck 131 14 tRNA trna NN cord-267475-6f4h3cck 131 15 - - HYPH cord-267475-6f4h3cck 131 16 synthetase synthetase NN cord-267475-6f4h3cck 131 17 ( ( -LRB- cord-267475-6f4h3cck 131 18 ' ' `` cord-267475-6f4h3cck 131 19 miniTrpRS minitrpr NNS cord-267475-6f4h3cck 131 20 ' ' POS cord-267475-6f4h3cck 131 21 ) ) -RRB- cord-267475-6f4h3cck 131 22 has have VBZ cord-267475-6f4h3cck 131 23 angiostatic angiostatic JJ cord-267475-6f4h3cck 131 24 activity activity NN cord-267475-6f4h3cck 131 25 ( ( -LRB- cord-267475-6f4h3cck 131 26 Wakasugi Wakasugi NNP cord-267475-6f4h3cck 131 27 et et NNP cord-267475-6f4h3cck 131 28 al al NNP cord-267475-6f4h3cck 131 29 . . NNP cord-267475-6f4h3cck 131 30 , , , cord-267475-6f4h3cck 131 31 2002 2002 CD cord-267475-6f4h3cck 131 32 ) ) -RRB- cord-267475-6f4h3cck 131 33 . . . cord-267475-6f4h3cck 132 1 The the DT cord-267475-6f4h3cck 132 2 entries entry NNS cord-267475-6f4h3cck 132 3 in in IN cord-267475-6f4h3cck 132 4 Table table NN cord-267475-6f4h3cck 132 5 2 2 CD cord-267475-6f4h3cck 132 6 and and CC cord-267475-6f4h3cck 132 7 some some DT cord-267475-6f4h3cck 132 8 other other JJ cord-267475-6f4h3cck 132 9 examples example NNS cord-267475-6f4h3cck 132 10 ( ( -LRB- cord-267475-6f4h3cck 132 11 Aichem Aichem NNP cord-267475-6f4h3cck 132 12 and and CC cord-267475-6f4h3cck 132 13 Mutzel Mutzel NNP cord-267475-6f4h3cck 132 14 , , , cord-267475-6f4h3cck 132 15 2001 2001 CD cord-267475-6f4h3cck 132 16 ; ; : cord-267475-6f4h3cck 132 17 Beuret Beuret NNP cord-267475-6f4h3cck 132 18 et et NNP cord-267475-6f4h3cck 132 19 al al NNP cord-267475-6f4h3cck 132 20 . . NNP cord-267475-6f4h3cck 132 21 , , , cord-267475-6f4h3cck 132 22 1999 1999 CD cord-267475-6f4h3cck 132 23 ; ; : cord-267475-6f4h3cck 132 24 Falvey Falvey NNP cord-267475-6f4h3cck 132 25 et et NNP cord-267475-6f4h3cck 132 26 al al NNP cord-267475-6f4h3cck 132 27 . . NNP cord-267475-6f4h3cck 132 28 , , , cord-267475-6f4h3cck 132 29 1995 1995 CD cord-267475-6f4h3cck 132 30 ; ; : cord-267475-6f4h3cck 132 31 Nagpal Nagpal NNP cord-267475-6f4h3cck 132 32 et et NNP cord-267475-6f4h3cck 132 33 al al NNP cord-267475-6f4h3cck 132 34 . . NNP cord-267475-6f4h3cck 132 35 , , , cord-267475-6f4h3cck 132 36 1992 1992 CD cord-267475-6f4h3cck 132 37 ) ) -RRB- cord-267475-6f4h3cck 132 38 are be VBP cord-267475-6f4h3cck 132 39 what what WP cord-267475-6f4h3cck 132 40 I -PRON- PRP cord-267475-6f4h3cck 132 41 call call VBP cord-267475-6f4h3cck 132 42 natural natural JJ cord-267475-6f4h3cck 132 43 tests test NNS cord-267475-6f4h3cck 132 44 of of IN cord-267475-6f4h3cck 132 45 the the DT cord-267475-6f4h3cck 132 46 position position NN cord-267475-6f4h3cck 132 47 rule rule NN cord-267475-6f4h3cck 132 48 . . . cord-267475-6f4h3cck 133 1 Additional additional JJ cord-267475-6f4h3cck 133 2 evidence evidence NN cord-267475-6f4h3cck 133 3 comes come VBZ cord-267475-6f4h3cck 133 4 from from IN cord-267475-6f4h3cck 133 5 experimental experimental JJ cord-267475-6f4h3cck 133 6 manipulations manipulation NNS cord-267475-6f4h3cck 133 7 wherein wherein WRB cord-267475-6f4h3cck 133 8 removal removal NN cord-267475-6f4h3cck 133 9 of of IN cord-267475-6f4h3cck 133 10 the the DT cord-267475-6f4h3cck 133 11 first first JJ cord-267475-6f4h3cck 133 12 AUG AUG NNP cord-267475-6f4h3cck 133 13 was be VBD cord-267475-6f4h3cck 133 14 shown show VBN cord-267475-6f4h3cck 133 15 to to TO cord-267475-6f4h3cck 133 16 activate activate VB cord-267475-6f4h3cck 133 17 initiation initiation NN cord-267475-6f4h3cck 133 18 from from IN cord-267475-6f4h3cck 133 19 a a DT cord-267475-6f4h3cck 133 20 downstream downstream JJ cord-267475-6f4h3cck 133 21 site site NN cord-267475-6f4h3cck 133 22 ( ( -LRB- cord-267475-6f4h3cck 133 23 Cahana Cahana NNP cord-267475-6f4h3cck 133 24 et et FW cord-267475-6f4h3cck 133 25 al al NNP cord-267475-6f4h3cck 133 26 . . NNP cord-267475-6f4h3cck 133 27 , , , cord-267475-6f4h3cck 133 28 2001 2001 CD cord-267475-6f4h3cck 133 29 ; ; : cord-267475-6f4h3cck 133 30 Chenik Chenik NNP cord-267475-6f4h3cck 133 31 et et NNP cord-267475-6f4h3cck 133 32 al al NNP cord-267475-6f4h3cck 133 33 . . NNP cord-267475-6f4h3cck 133 34 , , , cord-267475-6f4h3cck 133 35 1995 1995 CD cord-267475-6f4h3cck 133 36 ; ; : cord-267475-6f4h3cck 133 37 Tailor Tailor NNP cord-267475-6f4h3cck 133 38 et et NNP cord-267475-6f4h3cck 133 39 al al NNP cord-267475-6f4h3cck 133 40 . . NNP cord-267475-6f4h3cck 133 41 , , , cord-267475-6f4h3cck 133 42 2001 2001 CD cord-267475-6f4h3cck 133 43 ; ; : cord-267475-6f4h3cck 133 44 Thoma Thoma NNP cord-267475-6f4h3cck 133 45 et et NNP cord-267475-6f4h3cck 133 46 al al NNP cord-267475-6f4h3cck 133 47 . . NNP cord-267475-6f4h3cck 133 48 , , , cord-267475-6f4h3cck 133 49 2001 2001 CD cord-267475-6f4h3cck 133 50 ) ) -RRB- cord-267475-6f4h3cck 133 51 . . . cord-267475-6f4h3cck 134 1 The the DT cord-267475-6f4h3cck 134 2 scanning scanning NN cord-267475-6f4h3cck 134 3 mechanism mechanism NN cord-267475-6f4h3cck 134 4 predicts predict VBZ cord-267475-6f4h3cck 134 5 that that IN cord-267475-6f4h3cck 134 6 the the DT cord-267475-6f4h3cck 134 7 5 5 CD cord-267475-6f4h3cck 134 8 0 0 CD cord-267475-6f4h3cck 134 9 untranslated untranslated JJ cord-267475-6f4h3cck 134 10 region region NN cord-267475-6f4h3cck 134 11 ( ( -LRB- cord-267475-6f4h3cck 134 12 5 5 CD cord-267475-6f4h3cck 134 13 0 0 CD cord-267475-6f4h3cck 134 14 UTR UTR NNP cord-267475-6f4h3cck 134 15 , , , cord-267475-6f4h3cck 134 16 an an DT cord-267475-6f4h3cck 134 17 unfortunate unfortunate JJ cord-267475-6f4h3cck 134 18 misnomer misnomer NN cord-267475-6f4h3cck 134 19 ) ) -RRB- cord-267475-6f4h3cck 134 20 is be VBZ cord-267475-6f4h3cck 134 21 actually actually RB cord-267475-6f4h3cck 134 22 traversed traverse VBN cord-267475-6f4h3cck 134 23 by by IN cord-267475-6f4h3cck 134 24 ribosomes ribosome NNS cord-267475-6f4h3cck 134 25 . . . cord-267475-6f4h3cck 135 1 This this DT cord-267475-6f4h3cck 135 2 explains explain VBZ cord-267475-6f4h3cck 135 3 why why WRB cord-267475-6f4h3cck 135 4 translation translation NN cord-267475-6f4h3cck 135 5 of of IN cord-267475-6f4h3cck 135 6 the the DT cord-267475-6f4h3cck 135 7 major major JJ cord-267475-6f4h3cck 135 8 coding coding NN cord-267475-6f4h3cck 135 9 domain domain NN cord-267475-6f4h3cck 135 10 is be VBZ cord-267475-6f4h3cck 135 11 reduced reduce VBN cord-267475-6f4h3cck 135 12 when when WRB cord-267475-6f4h3cck 135 13 adventitious adventitious JJ cord-267475-6f4h3cck 135 14 out out IN cord-267475-6f4h3cck 135 15 - - HYPH cord-267475-6f4h3cck 135 16 offrame offrame NN cord-267475-6f4h3cck 135 17 AUG AUG NNP cord-267475-6f4h3cck 135 18 codons codon NNS cord-267475-6f4h3cck 135 19 occur occur VBP cord-267475-6f4h3cck 135 20 upstream upstream RB cord-267475-6f4h3cck 135 21 . . . cord-267475-6f4h3cck 136 1 The the DT cord-267475-6f4h3cck 136 2 upstream upstream JJ cord-267475-6f4h3cck 136 3 AUG AUG NNP cord-267475-6f4h3cck 136 4 codons codon NNS cord-267475-6f4h3cck 136 5 often often RB cord-267475-6f4h3cck 136 6 create create VBP cord-267475-6f4h3cck 136 7 small small JJ cord-267475-6f4h3cck 136 8 ORFs orf NNS cord-267475-6f4h3cck 136 9 ( ( -LRB- cord-267475-6f4h3cck 136 10 upORFs upORFs NNP cord-267475-6f4h3cck 136 11 ) ) -RRB- cord-267475-6f4h3cck 136 12 which which WDT cord-267475-6f4h3cck 136 13 are be VBP cord-267475-6f4h3cck 136 14 indeed indeed RB cord-267475-6f4h3cck 136 15 translated translate VBN cord-267475-6f4h3cck 136 16 , , , cord-267475-6f4h3cck 136 17 as as IN cord-267475-6f4h3cck 136 18 shown show VBN cord-267475-6f4h3cck 136 19 by by IN cord-267475-6f4h3cck 136 20 detecting detect VBG cord-267475-6f4h3cck 136 21 the the DT cord-267475-6f4h3cck 136 22 encoded encoded JJ cord-267475-6f4h3cck 136 23 peptide peptide NN cord-267475-6f4h3cck 136 24 ( ( -LRB- cord-267475-6f4h3cck 136 25 Hackett Hackett NNP cord-267475-6f4h3cck 136 26 et et NNP cord-267475-6f4h3cck 136 27 al al NNP cord-267475-6f4h3cck 136 28 . . NNP cord-267475-6f4h3cck 136 29 , , , cord-267475-6f4h3cck 136 30 1986 1986 CD cord-267475-6f4h3cck 136 31 ; ; : cord-267475-6f4h3cck 136 32 Raney Raney NNP cord-267475-6f4h3cck 136 33 et et NNP cord-267475-6f4h3cck 136 34 al al NNP cord-267475-6f4h3cck 136 35 . . NNP cord-267475-6f4h3cck 136 36 , , , cord-267475-6f4h3cck 136 37 2000 2000 CD cord-267475-6f4h3cck 136 38 ; ; : cord-267475-6f4h3cck 136 39 Wang Wang NNP cord-267475-6f4h3cck 136 40 and and CC cord-267475-6f4h3cck 136 41 Wessler Wessler NNP cord-267475-6f4h3cck 136 42 , , , cord-267475-6f4h3cck 136 43 2001 2001 CD cord-267475-6f4h3cck 136 44 ) ) -RRB- cord-267475-6f4h3cck 136 45 or or CC cord-267475-6f4h3cck 136 46 by by IN cord-267475-6f4h3cck 136 47 fusing fuse VBG cord-267475-6f4h3cck 136 48 a a DT cord-267475-6f4h3cck 136 49 reporter reporter NN cord-267475-6f4h3cck 136 50 gene gene NN cord-267475-6f4h3cck 136 51 to to IN cord-267475-6f4h3cck 136 52 the the DT cord-267475-6f4h3cck 136 53 upORF upORF . cord-267475-6f4h3cck 137 1 ( ( -LRB- cord-267475-6f4h3cck 137 2 Abastado Abastado NNP cord-267475-6f4h3cck 137 3 et et FW cord-267475-6f4h3cck 137 4 al al NNP cord-267475-6f4h3cck 137 5 . . NNP cord-267475-6f4h3cck 137 6 , , , cord-267475-6f4h3cck 137 7 1991 1991 CD cord-267475-6f4h3cck 138 1 ; ; : cord-267475-6f4h3cck 138 2 Donzé Donzé NNP cord-267475-6f4h3cck 138 3 et et NNP cord-267475-6f4h3cck 138 4 al al NNP cord-267475-6f4h3cck 138 5 . . NNP cord-267475-6f4h3cck 138 6 , , , cord-267475-6f4h3cck 138 7 1995 1995 CD cord-267475-6f4h3cck 138 8 ; ; : cord-267475-6f4h3cck 138 9 Liu Liu NNP cord-267475-6f4h3cck 138 10 et et NNP cord-267475-6f4h3cck 138 11 al al NNP cord-267475-6f4h3cck 138 12 . . NNP cord-267475-6f4h3cck 138 13 , , , cord-267475-6f4h3cck 138 14 1999 1999 CD cord-267475-6f4h3cck 138 15 ; ; : cord-267475-6f4h3cck 139 1 Steel steel NN cord-267475-6f4h3cck 139 2 et et FW cord-267475-6f4h3cck 139 3 al al NNP cord-267475-6f4h3cck 139 4 . . . cord-267475-6f4h3cck 140 1 , , , cord-267475-6f4h3cck 140 2 1996 1996 CD cord-267475-6f4h3cck 140 3 ; ; : cord-267475-6f4h3cck 140 4 Tanaka Tanaka NNP cord-267475-6f4h3cck 140 5 et et NNP cord-267475-6f4h3cck 140 6 al al NNP cord-267475-6f4h3cck 140 7 . . NNP cord-267475-6f4h3cck 140 8 , , , cord-267475-6f4h3cck 140 9 2001 2001 CD cord-267475-6f4h3cck 141 1 ; ; : cord-267475-6f4h3cck 141 2 Xu Xu NNP cord-267475-6f4h3cck 141 3 et et NNP cord-267475-6f4h3cck 141 4 al al NNP cord-267475-6f4h3cck 141 5 . . NNP cord-267475-6f4h3cck 141 6 , , , cord-267475-6f4h3cck 141 7 2001 2001 CD cord-267475-6f4h3cck 141 8 ) ) -RRB- cord-267475-6f4h3cck 141 9 . . . cord-267475-6f4h3cck 142 1 The the DT cord-267475-6f4h3cck 142 2 fusion fusion NN cord-267475-6f4h3cck 142 3 test test NN cord-267475-6f4h3cck 142 4 is be VBZ cord-267475-6f4h3cck 142 5 the the DT cord-267475-6f4h3cck 142 6 more more RBR cord-267475-6f4h3cck 142 7 reliable reliable JJ cord-267475-6f4h3cck 142 8 , , , cord-267475-6f4h3cck 142 9 as as IN cord-267475-6f4h3cck 142 10 small small JJ cord-267475-6f4h3cck 142 11 peptides peptide NNS cord-267475-6f4h3cck 142 12 are be VBP cord-267475-6f4h3cck 142 13 usually usually RB cord-267475-6f4h3cck 142 14 degraded degrade VBN cord-267475-6f4h3cck 142 15 rapidly rapidly RB cord-267475-6f4h3cck 142 16 . . . cord-267475-6f4h3cck 143 1 Even even RB cord-267475-6f4h3cck 143 2 if if IN cord-267475-6f4h3cck 143 3 upstream upstream JJ cord-267475-6f4h3cck 143 4 AUG AUG NNP cord-267475-6f4h3cck 143 5 codons codon NNS cord-267475-6f4h3cck 143 6 are be VBP cord-267475-6f4h3cck 143 7 arranged arrange VBN cord-267475-6f4h3cck 143 8 in in IN cord-267475-6f4h3cck 143 9 a a DT cord-267475-6f4h3cck 143 10 way way NN cord-267475-6f4h3cck 143 11 that that WDT cord-267475-6f4h3cck 143 12 allows allow VBZ cord-267475-6f4h3cck 143 13 reinitiation reinitiation NN cord-267475-6f4h3cck 143 14 , , , cord-267475-6f4h3cck 143 15 there there EX cord-267475-6f4h3cck 143 16 is be VBZ cord-267475-6f4h3cck 143 17 a a DT cord-267475-6f4h3cck 143 18 penalty penalty NN cord-267475-6f4h3cck 143 19 because because IN cord-267475-6f4h3cck 143 20 reinitiation reinitiation NN cord-267475-6f4h3cck 143 21 is be VBZ cord-267475-6f4h3cck 143 22 usually usually RB cord-267475-6f4h3cck 143 23 inefficient inefficient JJ cord-267475-6f4h3cck 143 24 . . . cord-267475-6f4h3cck 144 1 This this DT cord-267475-6f4h3cck 144 2 topic topic NN cord-267475-6f4h3cck 144 3 will will MD cord-267475-6f4h3cck 144 4 be be VB cord-267475-6f4h3cck 144 5 discussed discuss VBN cord-267475-6f4h3cck 144 6 at at IN cord-267475-6f4h3cck 144 7 length length NN cord-267475-6f4h3cck 144 8 in in IN cord-267475-6f4h3cck 144 9 Section section NN cord-267475-6f4h3cck 144 10 4 4 CD cord-267475-6f4h3cck 144 11 . . . cord-267475-6f4h3cck 145 1 The the DT cord-267475-6f4h3cck 145 2 hypothesis hypothesis NN cord-267475-6f4h3cck 145 3 that that IN cord-267475-6f4h3cck 145 4 the the DT cord-267475-6f4h3cck 145 5 5 5 CD cord-267475-6f4h3cck 145 6 0 0 CD cord-267475-6f4h3cck 145 7 UTR UTR NNP cord-267475-6f4h3cck 145 8 is be VBZ cord-267475-6f4h3cck 145 9 traversed traverse VBN cord-267475-6f4h3cck 145 10 by by IN cord-267475-6f4h3cck 145 11 ribosomes ribosome NNS cord-267475-6f4h3cck 145 12 explains explain VBZ cord-267475-6f4h3cck 145 13 why why WRB cord-267475-6f4h3cck 145 14 a a DT cord-267475-6f4h3cck 145 15 highly highly RB cord-267475-6f4h3cck 145 16 structured structure VBN cord-267475-6f4h3cck 145 17 5 5 CD cord-267475-6f4h3cck 145 18 0 0 CD cord-267475-6f4h3cck 145 19 leader leader NN cord-267475-6f4h3cck 145 20 sequence sequence NN cord-267475-6f4h3cck 145 21 is be VBZ cord-267475-6f4h3cck 145 22 so so RB cord-267475-6f4h3cck 145 23 detrimental detrimental JJ cord-267475-6f4h3cck 145 24 to to IN cord-267475-6f4h3cck 145 25 translation translation NN cord-267475-6f4h3cck 145 26 . . . cord-267475-6f4h3cck 146 1 Vertebrate vertebrate NN cord-267475-6f4h3cck 146 2 mRNAs mrnas PRP cord-267475-6f4h3cck 146 3 characteristically characteristically RB cord-267475-6f4h3cck 146 4 have have VBP cord-267475-6f4h3cck 146 5 long long JJ cord-267475-6f4h3cck 146 6 , , , cord-267475-6f4h3cck 146 7 GC gc NN cord-267475-6f4h3cck 146 8 - - HYPH cord-267475-6f4h3cck 146 9 rich rich JJ cord-267475-6f4h3cck 146 10 -hence -hence HYPH cord-267475-6f4h3cck 146 11 highly highly RB cord-267475-6f4h3cck 146 12 structured structure VBN cord-267475-6f4h3cck 146 13 -leader -leader NN cord-267475-6f4h3cck 146 14 sequences sequence NNS cord-267475-6f4h3cck 146 15 ( ( -LRB- cord-267475-6f4h3cck 146 16 Kozak Kozak NNP cord-267475-6f4h3cck 146 17 , , , cord-267475-6f4h3cck 146 18 1991a 1991a CD cord-267475-6f4h3cck 146 19 ; ; : cord-267475-6f4h3cck 146 20 Macleod Macleod NNP cord-267475-6f4h3cck 146 21 et et NNP cord-267475-6f4h3cck 146 22 al al NNP cord-267475-6f4h3cck 146 23 . . NNP cord-267475-6f4h3cck 146 24 , , , cord-267475-6f4h3cck 146 25 1998 1998 CD cord-267475-6f4h3cck 146 26 ) ) -RRB- cord-267475-6f4h3cck 146 27 , , , cord-267475-6f4h3cck 146 28 and and CC cord-267475-6f4h3cck 146 29 the the DT cord-267475-6f4h3cck 146 30 resulting result VBG cord-267475-6f4h3cck 146 31 difficulty difficulty NN cord-267475-6f4h3cck 146 32 in in IN cord-267475-6f4h3cck 146 33 translation translation NN cord-267475-6f4h3cck 146 34 has have VBZ cord-267475-6f4h3cck 146 35 been be VBN cord-267475-6f4h3cck 146 36 discovered discover VBN cord-267475-6f4h3cck 146 37 over over RB cord-267475-6f4h3cck 146 38 and and CC cord-267475-6f4h3cck 146 39 over over RB cord-267475-6f4h3cck 146 40 in in IN cord-267475-6f4h3cck 146 41 the the DT cord-267475-6f4h3cck 146 42 course course NN cord-267475-6f4h3cck 146 43 of of IN cord-267475-6f4h3cck 146 44 cloning clone VBG cord-267475-6f4h3cck 146 45 . . . cord-267475-6f4h3cck 147 1 Even even RB cord-267475-6f4h3cck 147 2 a a DT cord-267475-6f4h3cck 147 3 short short JJ cord-267475-6f4h3cck 147 4 GC gc NN cord-267475-6f4h3cck 147 5 - - HYPH cord-267475-6f4h3cck 147 6 rich rich JJ cord-267475-6f4h3cck 147 7 5 5 CD cord-267475-6f4h3cck 147 8 0 0 CD cord-267475-6f4h3cck 147 9 UTR UTR NNP cord-267475-6f4h3cck 147 10 can can MD cord-267475-6f4h3cck 147 11 inhibit inhibit VB cord-267475-6f4h3cck 147 12 profoundly profoundly RB cord-267475-6f4h3cck 147 13 , , , cord-267475-6f4h3cck 147 14 as as IN cord-267475-6f4h3cck 147 15 illustrated illustrate VBN cord-267475-6f4h3cck 147 16 in in IN cord-267475-6f4h3cck 147 17 cases case NNS cord-267475-6f4h3cck 147 18 where where WRB cord-267475-6f4h3cck 147 19 a a DT cord-267475-6f4h3cck 147 20 gene gene NN cord-267475-6f4h3cck 147 21 produces produce VBZ cord-267475-6f4h3cck 147 22 a a DT cord-267475-6f4h3cck 147 23 mixture mixture NN cord-267475-6f4h3cck 147 24 of of IN cord-267475-6f4h3cck 147 25 mRNAs mRNAs NNPS cord-267475-6f4h3cck 147 26 with with IN cord-267475-6f4h3cck 147 27 different different JJ cord-267475-6f4h3cck 147 28 leader leader NN cord-267475-6f4h3cck 147 29 sequences sequence NNS cord-267475-6f4h3cck 147 30 , , , cord-267475-6f4h3cck 147 31 and and CC cord-267475-6f4h3cck 147 32 the the DT cord-267475-6f4h3cck 147 33 worst worst RBS cord-267475-6f4h3cck 147 34 - - HYPH cord-267475-6f4h3cck 147 35 translated translate VBN cord-267475-6f4h3cck 147 36 mRNA mrna NN cord-267475-6f4h3cck 147 37 was be VBD cord-267475-6f4h3cck 147 38 found find VBN cord-267475-6f4h3cck 147 39 to to TO cord-267475-6f4h3cck 147 40 be be VB cord-267475-6f4h3cck 147 41 the the DT cord-267475-6f4h3cck 147 42 form form NN cord-267475-6f4h3cck 147 43 with with IN cord-267475-6f4h3cck 147 44 the the DT cord-267475-6f4h3cck 147 45 shortest short JJS cord-267475-6f4h3cck 147 46 5 5 CD cord-267475-6f4h3cck 147 47 0 0 CD cord-267475-6f4h3cck 147 48 UTR UTR NNP cord-267475-6f4h3cck 147 49 ( ( -LRB- cord-267475-6f4h3cck 147 50 Jiang Jiang NNP cord-267475-6f4h3cck 147 51 and and CC cord-267475-6f4h3cck 147 52 Lucy Lucy NNP cord-267475-6f4h3cck 147 53 , , , cord-267475-6f4h3cck 147 54 2001 2001 CD cord-267475-6f4h3cck 147 55 ; ; : cord-267475-6f4h3cck 147 56 Yang Yang NNP cord-267475-6f4h3cck 147 57 et et NNP cord-267475-6f4h3cck 147 58 al al NNP cord-267475-6f4h3cck 147 59 . . NNP cord-267475-6f4h3cck 147 60 , , , cord-267475-6f4h3cck 147 61 1998 1998 CD cord-267475-6f4h3cck 147 62 ) ) -RRB- cord-267475-6f4h3cck 147 63 . . . cord-267475-6f4h3cck 148 1 A a DT cord-267475-6f4h3cck 148 2 stem stem NN cord-267475-6f4h3cck 148 3 - - HYPH cord-267475-6f4h3cck 148 4 and and CC cord-267475-6f4h3cck 148 5 - - HYPH cord-267475-6f4h3cck 148 6 loop loop NN cord-267475-6f4h3cck 148 7 structure structure NN cord-267475-6f4h3cck 148 8 , , , cord-267475-6f4h3cck 148 9 stabilized stabilize VBD cord-267475-6f4h3cck 148 10 in in IN cord-267475-6f4h3cck 148 11 some some DT cord-267475-6f4h3cck 148 12 cases case NNS cord-267475-6f4h3cck 148 13 by by IN cord-267475-6f4h3cck 148 14 a a DT cord-267475-6f4h3cck 148 15 repressor repressor NN cord-267475-6f4h3cck 148 16 protein protein NN cord-267475-6f4h3cck 148 17 , , , cord-267475-6f4h3cck 148 18 is be VBZ cord-267475-6f4h3cck 148 19 most most RBS cord-267475-6f4h3cck 148 20 inhibitory inhibitory JJ cord-267475-6f4h3cck 148 21 when when WRB cord-267475-6f4h3cck 148 22 its -PRON- PRP$ cord-267475-6f4h3cck 148 23 proximity proximity NN cord-267475-6f4h3cck 148 24 to to IN cord-267475-6f4h3cck 148 25 the the DT cord-267475-6f4h3cck 148 26 5 5 CD cord-267475-6f4h3cck 148 27 0 0 CD cord-267475-6f4h3cck 148 28 end end NN cord-267475-6f4h3cck 148 29 blocks block VBZ cord-267475-6f4h3cck 148 30 ribosome ribosome NN cord-267475-6f4h3cck 148 31 binding binding NN cord-267475-6f4h3cck 148 32 ( ( -LRB- cord-267475-6f4h3cck 148 33 Goossen Goossen NNP cord-267475-6f4h3cck 148 34 and and CC cord-267475-6f4h3cck 148 35 Hentze Hentze NNP cord-267475-6f4h3cck 148 36 , , , cord-267475-6f4h3cck 148 37 1992 1992 CD cord-267475-6f4h3cck 148 38 ; ; : cord-267475-6f4h3cck 148 39 Kozak Kozak NNP cord-267475-6f4h3cck 148 40 , , , cord-267475-6f4h3cck 148 41 1989 1989 CD cord-267475-6f4h3cck 148 42 ; ; : cord-267475-6f4h3cck 148 43 Wang Wang NNP cord-267475-6f4h3cck 148 44 and and CC cord-267475-6f4h3cck 148 45 Wessler Wessler NNP cord-267475-6f4h3cck 148 46 , , , cord-267475-6f4h3cck 148 47 2001 2001 CD cord-267475-6f4h3cck 148 48 ) ) -RRB- cord-267475-6f4h3cck 148 49 . . . cord-267475-6f4h3cck 149 1 If if IN cord-267475-6f4h3cck 149 2 the the DT cord-267475-6f4h3cck 149 3 structure structure NN cord-267475-6f4h3cck 149 4 is be VBZ cord-267475-6f4h3cck 149 5 far far RB cord-267475-6f4h3cck 149 6 enough enough RB cord-267475-6f4h3cck 149 7 from from IN cord-267475-6f4h3cck 149 8 the the DT cord-267475-6f4h3cck 149 9 5 5 CD cord-267475-6f4h3cck 149 10 0 0 CD cord-267475-6f4h3cck 149 11 end end NN cord-267475-6f4h3cck 149 12 to to TO cord-267475-6f4h3cck 149 13 allow allow VB cord-267475-6f4h3cck 149 14 ribosome ribosome NN cord-267475-6f4h3cck 149 15 entry entry NN cord-267475-6f4h3cck 149 16 , , , cord-267475-6f4h3cck 149 17 the the DT cord-267475-6f4h3cck 149 18 advancing advance VBG cord-267475-6f4h3cck 149 19 40S 40s CD cord-267475-6f4h3cck 149 20 ribosome ribosome NN cord-267475-6f4h3cck 149 21 / / SYM cord-267475-6f4h3cck 149 22 factor factor NN cord-267475-6f4h3cck 149 23 complex complex NN cord-267475-6f4h3cck 149 24 apparently apparently RB cord-267475-6f4h3cck 149 25 has have VBZ cord-267475-6f4h3cck 149 26 some some DT cord-267475-6f4h3cck 149 27 ability ability NN cord-267475-6f4h3cck 149 28 to to TO cord-267475-6f4h3cck 149 29 disrupt disrupt VB cord-267475-6f4h3cck 149 30 base base NN cord-267475-6f4h3cck 149 31 pairing pairing NN cord-267475-6f4h3cck 149 32 , , , cord-267475-6f4h3cck 149 33 but but CC cord-267475-6f4h3cck 149 34 this this DT cord-267475-6f4h3cck 149 35 ability ability NN cord-267475-6f4h3cck 149 36 is be VBZ cord-267475-6f4h3cck 149 37 notably notably RB cord-267475-6f4h3cck 149 38 less less JJR cord-267475-6f4h3cck 149 39 than than IN cord-267475-6f4h3cck 149 40 that that DT cord-267475-6f4h3cck 149 41 of of IN cord-267475-6f4h3cck 149 42 80S 80 NNS cord-267475-6f4h3cck 149 43 elongating elongate VBG cord-267475-6f4h3cck 149 44 ribosomes ribosome NNS cord-267475-6f4h3cck 149 45 ( ( -LRB- cord-267475-6f4h3cck 149 46 Kozak Kozak NNP cord-267475-6f4h3cck 149 47 , , , cord-267475-6f4h3cck 149 48 1986a 1986a CD cord-267475-6f4h3cck 149 49 ( ( -LRB- cord-267475-6f4h3cck 149 50 Kozak Kozak NNP cord-267475-6f4h3cck 149 51 , , , cord-267475-6f4h3cck 149 52 , , , cord-267475-6f4h3cck 149 53 2001b 2001b CD cord-267475-6f4h3cck 149 54 Lingelbach Lingelbach NNP cord-267475-6f4h3cck 149 55 and and CC cord-267475-6f4h3cck 149 56 Dobberstein Dobberstein NNP cord-267475-6f4h3cck 149 57 , , , cord-267475-6f4h3cck 149 58 1988 1988 CD cord-267475-6f4h3cck 149 59 ; ; : cord-267475-6f4h3cck 149 60 Paraskeva Paraskeva NNP cord-267475-6f4h3cck 149 61 et et NNP cord-267475-6f4h3cck 149 62 al al NNP cord-267475-6f4h3cck 149 63 . . NNP cord-267475-6f4h3cck 149 64 , , , cord-267475-6f4h3cck 149 65 1999 1999 CD cord-267475-6f4h3cck 149 66 ) ) -RRB- cord-267475-6f4h3cck 149 67 and and CC cord-267475-6f4h3cck 149 68 is be VBZ cord-267475-6f4h3cck 149 69 curtailed curtail VBN cord-267475-6f4h3cck 149 70 in in IN cord-267475-6f4h3cck 149 71 yeast yeast NN cord-267475-6f4h3cck 149 72 ( ( -LRB- cord-267475-6f4h3cck 149 73 Koloteva Koloteva NNP cord-267475-6f4h3cck 149 74 et et NNP cord-267475-6f4h3cck 149 75 al al NNP cord-267475-6f4h3cck 149 76 . . NNP cord-267475-6f4h3cck 149 77 , , , cord-267475-6f4h3cck 149 78 1997 1997 CD cord-267475-6f4h3cck 149 79 ) ) -RRB- cord-267475-6f4h3cck 149 80 . . . cord-267475-6f4h3cck 150 1 While while IN cord-267475-6f4h3cck 150 2 there there EX cord-267475-6f4h3cck 150 3 are be VBP cord-267475-6f4h3cck 150 4 mechanisms mechanism NNS cord-267475-6f4h3cck 150 5 for for IN cord-267475-6f4h3cck 150 6 reducing reduce VBG cord-267475-6f4h3cck 150 7 the the DT cord-267475-6f4h3cck 150 8 inhibitory inhibitory JJ cord-267475-6f4h3cck 150 9 effects effect NNS cord-267475-6f4h3cck 150 10 of of IN cord-267475-6f4h3cck 150 11 upstream upstream JJ cord-267475-6f4h3cck 150 12 AUG AUG NNP cord-267475-6f4h3cck 150 13 codons codon NNS cord-267475-6f4h3cck 150 14 , , , cord-267475-6f4h3cck 150 15 as as IN cord-267475-6f4h3cck 150 16 discussed discuss VBN cord-267475-6f4h3cck 150 17 below below RB cord-267475-6f4h3cck 150 18 , , , cord-267475-6f4h3cck 150 19 no no DT cord-267475-6f4h3cck 150 20 mechanism mechanism NN cord-267475-6f4h3cck 150 21 has have VBZ cord-267475-6f4h3cck 150 22 yet yet RB cord-267475-6f4h3cck 150 23 been be VBN cord-267475-6f4h3cck 150 24 defined define VBN cord-267475-6f4h3cck 150 25 for for IN cord-267475-6f4h3cck 150 26 modulating modulate VBG cord-267475-6f4h3cck 150 27 the the DT cord-267475-6f4h3cck 150 28 inhibitory inhibitory JJ cord-267475-6f4h3cck 150 29 effects effect NNS cord-267475-6f4h3cck 150 30 of of IN cord-267475-6f4h3cck 150 31 secondary secondary JJ cord-267475-6f4h3cck 150 32 structure structure NN cord-267475-6f4h3cck 150 33 . . . cord-267475-6f4h3cck 151 1 Some some DT cord-267475-6f4h3cck 151 2 studies study NNS cord-267475-6f4h3cck 151 3 suggest suggest VBP cord-267475-6f4h3cck 151 4 that that IN cord-267475-6f4h3cck 151 5 secondary secondary JJ cord-267475-6f4h3cck 151 6 structure structure NN cord-267475-6f4h3cck 151 7 might may MD cord-267475-6f4h3cck 151 8 be be VB cord-267475-6f4h3cck 151 9 less less RBR cord-267475-6f4h3cck 151 10 inhibitory inhibitory JJ cord-267475-6f4h3cck 151 11 to to TO cord-267475-6f4h3cck 151 12 translation translation NN cord-267475-6f4h3cck 151 13 in in IN cord-267475-6f4h3cck 151 14 vivo vivo NN cord-267475-6f4h3cck 151 15 than than IN cord-267475-6f4h3cck 151 16 in in IN cord-267475-6f4h3cck 151 17 vitro vitro FW cord-267475-6f4h3cck 152 1 ( ( -LRB- cord-267475-6f4h3cck 152 2 Charron Charron NNP cord-267475-6f4h3cck 152 3 et et NNP cord-267475-6f4h3cck 152 4 al al NNP cord-267475-6f4h3cck 152 5 . . NNP cord-267475-6f4h3cck 152 6 , , , cord-267475-6f4h3cck 152 7 1998 1998 CD cord-267475-6f4h3cck 153 1 ; ; : cord-267475-6f4h3cck 153 2 Curnow Curnow NNP cord-267475-6f4h3cck 153 3 et et NNP cord-267475-6f4h3cck 153 4 al al NNP cord-267475-6f4h3cck 153 5 . . NNP cord-267475-6f4h3cck 153 6 , , , cord-267475-6f4h3cck 153 7 1995 1995 CD cord-267475-6f4h3cck 153 8 ; ; : cord-267475-6f4h3cck 153 9 Hensold Hensold NNP cord-267475-6f4h3cck 153 10 et et NNP cord-267475-6f4h3cck 153 11 al al NNP cord-267475-6f4h3cck 153 12 . . NNP cord-267475-6f4h3cck 153 13 , , , cord-267475-6f4h3cck 153 14 1997 1997 CD cord-267475-6f4h3cck 154 1 ; ; : cord-267475-6f4h3cck 154 2 Hoover Hoover NNP cord-267475-6f4h3cck 154 3 et et NNP cord-267475-6f4h3cck 154 4 al al NNP cord-267475-6f4h3cck 154 5 . . NNP cord-267475-6f4h3cck 154 6 , , , cord-267475-6f4h3cck 154 7 1997 1997 CD cord-267475-6f4h3cck 154 8 ; ; . cord-267475-6f4h3cck 155 1 Morrish Morrish NNP cord-267475-6f4h3cck 155 2 and and CC cord-267475-6f4h3cck 155 3 Rumsby Rumsby NNP cord-267475-6f4h3cck 155 4 , , , cord-267475-6f4h3cck 155 5 2001 2001 CD cord-267475-6f4h3cck 155 6 ; ; : cord-267475-6f4h3cck 155 7 Van Van NNP cord-267475-6f4h3cck 155 8 der der NNP cord-267475-6f4h3cck 155 9 Velden Velden NNP cord-267475-6f4h3cck 155 10 et et FW cord-267475-6f4h3cck 155 11 al al NNP cord-267475-6f4h3cck 155 12 . . NNP cord-267475-6f4h3cck 155 13 , , , cord-267475-6f4h3cck 155 14 2002 2002 CD cord-267475-6f4h3cck 155 15 ) ) -RRB- cord-267475-6f4h3cck 155 16 . . . cord-267475-6f4h3cck 156 1 This this DT cord-267475-6f4h3cck 156 2 could could MD cord-267475-6f4h3cck 156 3 be be VB cord-267475-6f4h3cck 156 4 due due JJ cord-267475-6f4h3cck 156 5 to to IN cord-267475-6f4h3cck 156 6 production production NN cord-267475-6f4h3cck 156 7 of of IN cord-267475-6f4h3cck 156 8 an an DT cord-267475-6f4h3cck 156 9 alternative alternative JJ cord-267475-6f4h3cck 156 10 transcript transcript NN cord-267475-6f4h3cck 156 11 that that WDT cord-267475-6f4h3cck 156 12 simply simply RB cord-267475-6f4h3cck 156 13 eliminates eliminate VBZ cord-267475-6f4h3cck 156 14 the the DT cord-267475-6f4h3cck 156 15 secondary secondary JJ cord-267475-6f4h3cck 156 16 structure structure NN cord-267475-6f4h3cck 156 17 -a -a HYPH cord-267475-6f4h3cck 156 18 reasonable reasonable JJ cord-267475-6f4h3cck 156 19 possibility possibility NN cord-267475-6f4h3cck 156 20 given give VBN cord-267475-6f4h3cck 156 21 that that IN cord-267475-6f4h3cck 156 22 GC gc NN cord-267475-6f4h3cck 156 23 - - HYPH cord-267475-6f4h3cck 156 24 rich rich JJ cord-267475-6f4h3cck 156 25 domains domain NNS cord-267475-6f4h3cck 156 26 often often RB cord-267475-6f4h3cck 156 27 harbor harbor VBP cord-267475-6f4h3cck 156 28 promoter promoter NN cord-267475-6f4h3cck 156 29 elements element NNS cord-267475-6f4h3cck 156 30 -or -or : cord-267475-6f4h3cck 156 31 to to IN cord-267475-6f4h3cck 156 32 modification modification NN cord-267475-6f4h3cck 156 33 of of IN cord-267475-6f4h3cck 156 34 the the DT cord-267475-6f4h3cck 156 35 translation translation NN cord-267475-6f4h3cck 156 36 machinery machinery NN cord-267475-6f4h3cck 156 37 . . . cord-267475-6f4h3cck 157 1 Interpretation interpretation NN cord-267475-6f4h3cck 157 2 of of IN cord-267475-6f4h3cck 157 3 in in IN cord-267475-6f4h3cck 157 4 vivo vivo NN cord-267475-6f4h3cck 157 5 tests test NNS cord-267475-6f4h3cck 157 6 of of IN cord-267475-6f4h3cck 157 7 translation translation NN cord-267475-6f4h3cck 157 8 could could MD cord-267475-6f4h3cck 157 9 also also RB cord-267475-6f4h3cck 157 10 be be VB cord-267475-6f4h3cck 157 11 complicated complicate VBN cord-267475-6f4h3cck 157 12 by by IN cord-267475-6f4h3cck 157 13 effects effect NNS cord-267475-6f4h3cck 157 14 of of IN cord-267475-6f4h3cck 157 15 secondary secondary JJ cord-267475-6f4h3cck 157 16 structure structure NN cord-267475-6f4h3cck 157 17 on on IN cord-267475-6f4h3cck 157 18 mRNA mRNA NNP cord-267475-6f4h3cck 157 19 stability stability NN cord-267475-6f4h3cck 158 1 ( ( -LRB- cord-267475-6f4h3cck 158 2 Stefanovic Stefanovic NNP cord-267475-6f4h3cck 158 3 et et FW cord-267475-6f4h3cck 158 4 al al NNP cord-267475-6f4h3cck 158 5 . . NNP cord-267475-6f4h3cck 158 6 , , , cord-267475-6f4h3cck 158 7 1999 1999 CD cord-267475-6f4h3cck 158 8 ) ) -RRB- cord-267475-6f4h3cck 158 9 . . . cord-267475-6f4h3cck 159 1 Whether whether IN cord-267475-6f4h3cck 159 2 and and CC cord-267475-6f4h3cck 159 3 how how WRB cord-267475-6f4h3cck 159 4 translation translation NN cord-267475-6f4h3cck 159 5 of of IN cord-267475-6f4h3cck 159 6 GC GC NNP cord-267475-6f4h3cck 159 7 - - HYPH cord-267475-6f4h3cck 159 8 rich rich JJ cord-267475-6f4h3cck 159 9 leader leader NN cord-267475-6f4h3cck 159 10 sequences sequence NNS cord-267475-6f4h3cck 159 11 might may MD cord-267475-6f4h3cck 159 12 improve improve VB cord-267475-6f4h3cck 159 13 in in IN cord-267475-6f4h3cck 159 14 exponentially exponentially RB cord-267475-6f4h3cck 159 15 growing grow VBG cord-267475-6f4h3cck 159 16 cells cell NNS cord-267475-6f4h3cck 159 17 ( ( -LRB- cord-267475-6f4h3cck 159 18 Nielsen Nielsen NNP cord-267475-6f4h3cck 159 19 et et NNP cord-267475-6f4h3cck 159 20 al al NNP cord-267475-6f4h3cck 159 21 . . NNP cord-267475-6f4h3cck 159 22 , , , cord-267475-6f4h3cck 159 23 1995 1995 CD cord-267475-6f4h3cck 159 24 ) ) -RRB- cord-267475-6f4h3cck 159 25 remains remain VBZ cord-267475-6f4h3cck 159 26 an an DT cord-267475-6f4h3cck 159 27 important important JJ cord-267475-6f4h3cck 159 28 open open JJ cord-267475-6f4h3cck 159 29 question question NN cord-267475-6f4h3cck 159 30 . . . cord-267475-6f4h3cck 160 1 The the DT cord-267475-6f4h3cck 160 2 scanning scanning NN cord-267475-6f4h3cck 160 3 mechanism mechanism NN cord-267475-6f4h3cck 160 4 rationalizes rationalize VBZ cord-267475-6f4h3cck 160 5 the the DT cord-267475-6f4h3cck 160 6 occurrence occurrence NN cord-267475-6f4h3cck 160 7 of of IN cord-267475-6f4h3cck 160 8 initiation initiation NN cord-267475-6f4h3cck 160 9 at at IN cord-267475-6f4h3cck 160 10 upstream upstream JJ cord-267475-6f4h3cck 160 11 ACG ACG NNP cord-267475-6f4h3cck 160 12 or or CC cord-267475-6f4h3cck 160 13 CUG CUG NNP cord-267475-6f4h3cck 160 14 codons codon NNS cord-267475-6f4h3cck 160 15 in in IN cord-267475-6f4h3cck 160 16 some some DT cord-267475-6f4h3cck 160 17 mRNAs mrna NNS cord-267475-6f4h3cck 160 18 . . . cord-267475-6f4h3cck 161 1 These these DT cord-267475-6f4h3cck 161 2 alternative alternative JJ cord-267475-6f4h3cck 161 3 codons codon NNS cord-267475-6f4h3cck 161 4 are be VBP cord-267475-6f4h3cck 161 5 usually usually RB cord-267475-6f4h3cck 161 6 too too RB cord-267475-6f4h3cck 161 7 weak weak JJ cord-267475-6f4h3cck 161 8 to to TO cord-267475-6f4h3cck 161 9 actually actually RB cord-267475-6f4h3cck 161 10 substitute substitute VB cord-267475-6f4h3cck 161 11 for for IN cord-267475-6f4h3cck 161 12 the the DT cord-267475-6f4h3cck 161 13 AUG AUG NNP cord-267475-6f4h3cck 161 14 START START NNP cord-267475-6f4h3cck 161 15 codon codon NN cord-267475-6f4h3cck 161 16 ( ( -LRB- cord-267475-6f4h3cck 161 17 reviewed review VBN cord-267475-6f4h3cck 161 18 by by IN cord-267475-6f4h3cck 161 19 Kozak Kozak NNP cord-267475-6f4h3cck 161 20 , , , cord-267475-6f4h3cck 161 21 1999 1999 CD cord-267475-6f4h3cck 161 22 ; ; : cord-267475-6f4h3cck 161 23 for for IN cord-267475-6f4h3cck 161 24 some some DT cord-267475-6f4h3cck 161 25 exceptions exception NNS cord-267475-6f4h3cck 161 26 see see VBP cord-267475-6f4h3cck 161 27 Falvey Falvey NNP cord-267475-6f4h3cck 161 28 et et NNP cord-267475-6f4h3cck 161 29 al al NNP cord-267475-6f4h3cck 161 30 . . NNP cord-267475-6f4h3cck 161 31 , , , cord-267475-6f4h3cck 161 32 1995 1995 CD cord-267475-6f4h3cck 161 33 ; ; : cord-267475-6f4h3cck 162 1 Kiefer Kiefer NNP cord-267475-6f4h3cck 162 2 et et NNP cord-267475-6f4h3cck 162 3 al al NNP cord-267475-6f4h3cck 162 4 . . . cord-267475-6f4h3cck 163 1 , , , cord-267475-6f4h3cck 163 2 1994 1994 CD cord-267475-6f4h3cck 163 3 ; ; : cord-267475-6f4h3cck 163 4 Riechmann Riechmann NNP cord-267475-6f4h3cck 163 5 et et NNP cord-267475-6f4h3cck 163 6 al al NNP cord-267475-6f4h3cck 163 7 . . . cord-267475-6f4h3cck 164 1 , , , cord-267475-6f4h3cck 164 2 1999 1999 CD cord-267475-6f4h3cck 164 3 ; ; : cord-267475-6f4h3cck 164 4 Sadler Sadler NNP cord-267475-6f4h3cck 164 5 et et NNP cord-267475-6f4h3cck 164 6 al al NNP cord-267475-6f4h3cck 164 7 . . NNP cord-267475-6f4h3cck 164 8 , , , cord-267475-6f4h3cck 164 9 1999 1999 CD cord-267475-6f4h3cck 164 10 ) ) -RRB- cord-267475-6f4h3cck 164 11 . . . cord-267475-6f4h3cck 165 1 It -PRON- PRP cord-267475-6f4h3cck 165 2 is be VBZ cord-267475-6f4h3cck 165 3 not not RB cord-267475-6f4h3cck 165 4 uncommon uncommon JJ cord-267475-6f4h3cck 165 5 , , , cord-267475-6f4h3cck 165 6 however however RB cord-267475-6f4h3cck 165 7 , , , cord-267475-6f4h3cck 165 8 for for IN cord-267475-6f4h3cck 165 9 initiation initiation NN cord-267475-6f4h3cck 165 10 to to TO cord-267475-6f4h3cck 165 11 occur occur VB cord-267475-6f4h3cck 165 12 at at IN cord-267475-6f4h3cck 165 13 an an DT cord-267475-6f4h3cck 165 14 upstream upstream JJ cord-267475-6f4h3cck 165 15 non non JJ cord-267475-6f4h3cck 165 16 - - JJ cord-267475-6f4h3cck 165 17 AUG AUG NNP cord-267475-6f4h3cck 165 18 codon codon NN cord-267475-6f4h3cck 165 19 in in IN cord-267475-6f4h3cck 165 20 addition addition NN cord-267475-6f4h3cck 165 21 to to IN cord-267475-6f4h3cck 165 22 the the DT cord-267475-6f4h3cck 165 23 first first JJ cord-267475-6f4h3cck 165 24 AUG AUG NNP cord-267475-6f4h3cck 165 25 ( ( -LRB- cord-267475-6f4h3cck 165 26 see see VB cord-267475-6f4h3cck 165 27 leaky leaky JJ cord-267475-6f4h3cck 165 28 scanning scanning NN cord-267475-6f4h3cck 165 29 in in IN cord-267475-6f4h3cck 165 30 Section section NN cord-267475-6f4h3cck 165 31 3 3 CD cord-267475-6f4h3cck 165 32 ) ) -RRB- cord-267475-6f4h3cck 165 33 . . . cord-267475-6f4h3cck 166 1 This this DT cord-267475-6f4h3cck 166 2 is be VBZ cord-267475-6f4h3cck 166 3 observed observe VBN cord-267475-6f4h3cck 166 4 frequently frequently RB cord-267475-6f4h3cck 166 5 with with IN cord-267475-6f4h3cck 166 6 cellular cellular JJ cord-267475-6f4h3cck 166 7 genes gene NNS cord-267475-6f4h3cck 166 8 that that WDT cord-267475-6f4h3cck 166 9 have have VBP cord-267475-6f4h3cck 166 10 highly highly RB cord-267475-6f4h3cck 166 11 structured structure VBN cord-267475-6f4h3cck 166 12 , , , cord-267475-6f4h3cck 166 13 GC gc NN cord-267475-6f4h3cck 166 14 - - HYPH cord-267475-6f4h3cck 166 15 rich rich JJ cord-267475-6f4h3cck 166 16 leader leader NN cord-267475-6f4h3cck 166 17 sequences sequence NNS cord-267475-6f4h3cck 166 18 ( ( -LRB- cord-267475-6f4h3cck 166 19 Kozak Kozak NNP cord-267475-6f4h3cck 166 20 , , , cord-267475-6f4h3cck 166 21 1991b 1991b CD cord-267475-6f4h3cck 166 22 ) ) -RRB- cord-267475-6f4h3cck 166 23 , , , cord-267475-6f4h3cck 166 24 perhaps perhaps RB cord-267475-6f4h3cck 166 25 because because IN cord-267475-6f4h3cck 166 26 secondary secondary JJ cord-267475-6f4h3cck 166 27 structure structure NN cord-267475-6f4h3cck 166 28 slows slow VBZ cord-267475-6f4h3cck 166 29 scanning scan VBG cord-267475-6f4h3cck 166 30 and and CC cord-267475-6f4h3cck 166 31 thus thus RB cord-267475-6f4h3cck 166 32 allows allow VBZ cord-267475-6f4h3cck 166 33 more more JJR cord-267475-6f4h3cck 166 34 time time NN cord-267475-6f4h3cck 166 35 for for IN cord-267475-6f4h3cck 166 36 the the DT cord-267475-6f4h3cck 166 37 mismatched mismatched JJ cord-267475-6f4h3cck 166 38 codon codon NN cord-267475-6f4h3cck 166 39 to to TO cord-267475-6f4h3cck 166 40 pair pair VB cord-267475-6f4h3cck 166 41 with with IN cord-267475-6f4h3cck 167 1 Met Met NNP cord-267475-6f4h3cck 167 2 - - HYPH cord-267475-6f4h3cck 167 3 tRNA tRNA NNP cord-267475-6f4h3cck 167 4 i i PRP cord-267475-6f4h3cck 167 5 . . . cord-267475-6f4h3cck 168 1 With with IN cord-267475-6f4h3cck 168 2 some some DT cord-267475-6f4h3cck 168 3 viruses virus NNS cord-267475-6f4h3cck 168 4 , , , cord-267475-6f4h3cck 168 5 the the DT cord-267475-6f4h3cck 168 6 extra extra JJ cord-267475-6f4h3cck 168 7 protein protein NN cord-267475-6f4h3cck 168 8 isoform isoform NN cord-267475-6f4h3cck 168 9 initiated initiate VBD cord-267475-6f4h3cck 168 10 from from IN cord-267475-6f4h3cck 168 11 an an DT cord-267475-6f4h3cck 168 12 upstream upstream JJ cord-267475-6f4h3cck 168 13 non non JJ cord-267475-6f4h3cck 168 14 - - JJ cord-267475-6f4h3cck 168 15 AUG AUG NNP cord-267475-6f4h3cck 168 16 codon codon NN cord-267475-6f4h3cck 168 17 serves serve VBZ cord-267475-6f4h3cck 168 18 an an DT cord-267475-6f4h3cck 168 19 essential essential JJ cord-267475-6f4h3cck 168 20 function function NN cord-267475-6f4h3cck 168 21 ( ( -LRB- cord-267475-6f4h3cck 168 22 Muralidhar Muralidhar NNP cord-267475-6f4h3cck 168 23 et et NNP cord-267475-6f4h3cck 168 24 al al NNP cord-267475-6f4h3cck 168 25 . . NNP cord-267475-6f4h3cck 168 26 , , , cord-267475-6f4h3cck 168 27 1994 1994 CD cord-267475-6f4h3cck 168 28 ; ; : cord-267475-6f4h3cck 168 29 Portis Portis NNP cord-267475-6f4h3cck 168 30 et et NNP cord-267475-6f4h3cck 168 31 al al NNP cord-267475-6f4h3cck 168 32 . . . cord-267475-6f4h3cck 169 1 , , , cord-267475-6f4h3cck 169 2 1994 1994 CD cord-267475-6f4h3cck 169 3 Portis Portis NNP cord-267475-6f4h3cck 169 4 et et NNP cord-267475-6f4h3cck 169 5 al al NNP cord-267475-6f4h3cck 169 6 . . . cord-267475-6f4h3cck 170 1 , , , cord-267475-6f4h3cck 170 2 , , , cord-267475-6f4h3cck 170 3 1996 1996 CD cord-267475-6f4h3cck 170 4 . . . cord-267475-6f4h3cck 171 1 While while IN cord-267475-6f4h3cck 171 2 the the DT cord-267475-6f4h3cck 171 3 N n NN cord-267475-6f4h3cck 171 4 - - HYPH cord-267475-6f4h3cck 171 5 terminally terminally RB cord-267475-6f4h3cck 171 6 - - HYPH cord-267475-6f4h3cck 171 7 extended extend VBN cord-267475-6f4h3cck 171 8 isoforms isoform NNS cord-267475-6f4h3cck 171 9 derived derive VBN cord-267475-6f4h3cck 171 10 from from IN cord-267475-6f4h3cck 171 11 some some DT cord-267475-6f4h3cck 171 12 cellular cellular JJ cord-267475-6f4h3cck 171 13 genes gene NNS cord-267475-6f4h3cck 171 14 also also RB cord-267475-6f4h3cck 171 15 display display VBP cord-267475-6f4h3cck 171 16 distinct distinct JJ cord-267475-6f4h3cck 171 17 functions function NNS cord-267475-6f4h3cck 171 18 ( ( -LRB- cord-267475-6f4h3cck 171 19 Arnaud Arnaud NNP cord-267475-6f4h3cck 171 20 Table Table NNP cord-267475-6f4h3cck 171 21 2 2 CD cord-267475-6f4h3cck 171 22 Partial partial JJ cord-267475-6f4h3cck 171 23 list list NN cord-267475-6f4h3cck 171 24 of of IN cord-267475-6f4h3cck 171 25 vertebrate vertebrate JJ cord-267475-6f4h3cck 171 26 genes gene NNS cord-267475-6f4h3cck 171 27 that that WDT cord-267475-6f4h3cck 171 28 produce produce VBP cord-267475-6f4h3cck 171 29 a a DT cord-267475-6f4h3cck 171 30 second second JJ cord-267475-6f4h3cck 171 31 , , , cord-267475-6f4h3cck 171 32 shorter short JJR cord-267475-6f4h3cck 171 33 version version NN cord-267475-6f4h3cck 171 34 of of IN cord-267475-6f4h3cck 171 35 the the DT cord-267475-6f4h3cck 171 36 encoded encode VBN cord-267475-6f4h3cck 171 37 protein protein NN cord-267475-6f4h3cck 171 38 via via IN cord-267475-6f4h3cck 171 39 a a DT cord-267475-6f4h3cck 171 40 second second JJ cord-267475-6f4h3cck 171 41 form form NN cord-267475-6f4h3cck 171 42 of of IN cord-267475-6f4h3cck 171 43 mRNA mrna NN cord-267475-6f4h3cck 171 44 in in IN cord-267475-6f4h3cck 171 45 which which WDT cord-267475-6f4h3cck 171 46 an an DT cord-267475-6f4h3cck 171 47 internal internal JJ cord-267475-6f4h3cck 171 48 AUG AUG NNP cord-267475-6f4h3cck 171 49 codon codon NN cord-267475-6f4h3cck 171 50 becomes become VBZ cord-267475-6f4h3cck 171 51 a a DT cord-267475-6f4h3cck 171 52 functional functional JJ cord-267475-6f4h3cck 171 53 start start NN cord-267475-6f4h3cck 171 54 site site NN cord-267475-6f4h3cck 171 55 upon upon IN cord-267475-6f4h3cck 171 56 elimination elimination NN cord-267475-6f4h3cck 171 57 of of IN cord-267475-6f4h3cck 171 58 the the DT cord-267475-6f4h3cck 171 59 upstream upstream JJ cord-267475-6f4h3cck 171 60 AUG AUG NNP cord-267475-6f4h3cck 171 61 START START NNP cord-267475-6f4h3cck 172 1 Sun Sun NNP cord-267475-6f4h3cck 172 2 et et NNP cord-267475-6f4h3cck 172 3 al al NNP cord-267475-6f4h3cck 172 4 . . NNP cord-267475-6f4h3cck 172 5 , , , cord-267475-6f4h3cck 173 1 1995 1995 CD cord-267475-6f4h3cck 174 1 a a DT cord-267475-6f4h3cck 174 2 Production production NN cord-267475-6f4h3cck 174 3 of of IN cord-267475-6f4h3cck 174 4 long long JJ cord-267475-6f4h3cck 174 5 and and CC cord-267475-6f4h3cck 174 6 short short JJ cord-267475-6f4h3cck 174 7 protein protein NN cord-267475-6f4h3cck 174 8 isoforms isoform NNS cord-267475-6f4h3cck 174 9 via via IN cord-267475-6f4h3cck 174 10 this this DT cord-267475-6f4h3cck 174 11 mechanism mechanism NN cord-267475-6f4h3cck 174 12 is be VBZ cord-267475-6f4h3cck 174 13 seen see VBN cord-267475-6f4h3cck 174 14 also also RB cord-267475-6f4h3cck 174 15 with with IN cord-267475-6f4h3cck 174 16 genes gene NNS cord-267475-6f4h3cck 174 17 from from IN cord-267475-6f4h3cck 174 18 insects insect NNS cord-267475-6f4h3cck 174 19 ( ( -LRB- cord-267475-6f4h3cck 174 20 Mével Mével NNP cord-267475-6f4h3cck 174 21 - - HYPH cord-267475-6f4h3cck 174 22 Ninio Ninio NNP cord-267475-6f4h3cck 174 23 et et NNP cord-267475-6f4h3cck 174 24 al al NNP cord-267475-6f4h3cck 174 25 . . NNP cord-267475-6f4h3cck 174 26 , , , cord-267475-6f4h3cck 174 27 1996 1996 CD cord-267475-6f4h3cck 174 28 ) ) -RRB- cord-267475-6f4h3cck 174 29 , , , cord-267475-6f4h3cck 174 30 plants plant NNS cord-267475-6f4h3cck 174 31 ( ( -LRB- cord-267475-6f4h3cck 174 32 Cunillera Cunillera NNP cord-267475-6f4h3cck 174 33 et et FW cord-267475-6f4h3cck 174 34 al al NNP cord-267475-6f4h3cck 174 35 . . NNP cord-267475-6f4h3cck 174 36 , , , cord-267475-6f4h3cck 174 37 1997 1997 CD cord-267475-6f4h3cck 174 38 ; ; : cord-267475-6f4h3cck 174 39 Wimmer Wimmer NNP cord-267475-6f4h3cck 174 40 et et NNP cord-267475-6f4h3cck 174 41 al al NNP cord-267475-6f4h3cck 174 42 . . NNP cord-267475-6f4h3cck 174 43 , , , cord-267475-6f4h3cck 174 44 1997 1997 CD cord-267475-6f4h3cck 174 45 ) ) -RRB- cord-267475-6f4h3cck 174 46 , , , cord-267475-6f4h3cck 174 47 yeast yeast NN cord-267475-6f4h3cck 174 48 ( ( -LRB- cord-267475-6f4h3cck 174 49 Beltzer Beltzer NNP cord-267475-6f4h3cck 174 50 et et NNP cord-267475-6f4h3cck 174 51 al al NNP cord-267475-6f4h3cck 174 52 . . NNP cord-267475-6f4h3cck 174 53 , , , cord-267475-6f4h3cck 174 54 1988 1988 CD cord-267475-6f4h3cck 174 55 ; ; : cord-267475-6f4h3cck 174 56 Carlson Carlson NNP cord-267475-6f4h3cck 174 57 et et NNP cord-267475-6f4h3cck 174 58 al al NNP cord-267475-6f4h3cck 174 59 . . NNP cord-267475-6f4h3cck 174 60 , , , cord-267475-6f4h3cck 174 61 1983 1983 CD cord-267475-6f4h3cck 174 62 ; ; : cord-267475-6f4h3cck 174 63 Chatton Chatton NNP cord-267475-6f4h3cck 174 64 et et NNP cord-267475-6f4h3cck 174 65 al al NNP cord-267475-6f4h3cck 174 66 . . NNP cord-267475-6f4h3cck 174 67 , , , cord-267475-6f4h3cck 174 68 1988 1988 CD cord-267475-6f4h3cck 174 69 ; ; : cord-267475-6f4h3cck 174 70 Ellis Ellis NNP cord-267475-6f4h3cck 174 71 et et NNP cord-267475-6f4h3cck 174 72 al al NNP cord-267475-6f4h3cck 174 73 . . . cord-267475-6f4h3cck 175 1 , , , cord-267475-6f4h3cck 175 2 1989 1989 CD cord-267475-6f4h3cck 175 3 ; ; : cord-267475-6f4h3cck 175 4 Gammie Gammie NNP cord-267475-6f4h3cck 175 5 et et NNP cord-267475-6f4h3cck 175 6 al al NNP cord-267475-6f4h3cck 175 7 . . NNP cord-267475-6f4h3cck 175 8 , , , cord-267475-6f4h3cck 175 9 1999 1999 CD cord-267475-6f4h3cck 175 10 ; ; : cord-267475-6f4h3cck 176 1 Natsoulis Natsoulis NNP cord-267475-6f4h3cck 176 2 et et NNP cord-267475-6f4h3cck 176 3 al al NNP cord-267475-6f4h3cck 176 4 . . NNP cord-267475-6f4h3cck 176 5 , , , cord-267475-6f4h3cck 176 6 1986 1986 CD cord-267475-6f4h3cck 177 1 ; ; : cord-267475-6f4h3cck 177 2 Wolfe Wolfe NNP cord-267475-6f4h3cck 177 3 et et NNP cord-267475-6f4h3cck 177 4 al al NNP cord-267475-6f4h3cck 177 5 . . NNP cord-267475-6f4h3cck 177 6 , , , cord-267475-6f4h3cck 177 7 1996 1996 CD cord-267475-6f4h3cck 177 8 ) ) -RRB- cord-267475-6f4h3cck 177 9 and and CC cord-267475-6f4h3cck 177 10 viruses virus NNS cord-267475-6f4h3cck 177 11 ( ( -LRB- cord-267475-6f4h3cck 177 12 Barbosa Barbosa NNP cord-267475-6f4h3cck 177 13 and and CC cord-267475-6f4h3cck 177 14 Wettstein Wettstein NNP cord-267475-6f4h3cck 177 15 , , , cord-267475-6f4h3cck 177 16 1988 1988 CD cord-267475-6f4h3cck 177 17 ; ; : cord-267475-6f4h3cck 177 18 Lambert Lambert NNP cord-267475-6f4h3cck 177 19 et et NNP cord-267475-6f4h3cck 177 20 al al NNP cord-267475-6f4h3cck 177 21 . . NNP cord-267475-6f4h3cck 177 22 , , , cord-267475-6f4h3cck 177 23 1987 1987 CD cord-267475-6f4h3cck 177 24 ; ; . cord-267475-6f4h3cck 178 1 Liu Liu NNP cord-267475-6f4h3cck 178 2 and and CC cord-267475-6f4h3cck 178 3 Roizman Roizman NNP cord-267475-6f4h3cck 178 4 , , , cord-267475-6f4h3cck 178 5 1991 1991 CD cord-267475-6f4h3cck 178 6 ; ; : cord-267475-6f4h3cck 178 7 Liu Liu NNP cord-267475-6f4h3cck 178 8 and and CC cord-267475-6f4h3cck 178 9 Biegalke Biegalke NNP cord-267475-6f4h3cck 178 10 , , , cord-267475-6f4h3cck 178 11 2002 2002 CD cord-267475-6f4h3cck 178 12 ; ; : cord-267475-6f4h3cck 178 13 Weimer Weimer NNP cord-267475-6f4h3cck 178 14 et et NNP cord-267475-6f4h3cck 178 15 al al NNP cord-267475-6f4h3cck 178 16 . . NNP cord-267475-6f4h3cck 178 17 , , , cord-267475-6f4h3cck 178 18 1987 1987 CD cord-267475-6f4h3cck 178 19 ; ; . cord-267475-6f4h3cck 179 1 Welch Welch NNP cord-267475-6f4h3cck 179 2 et et NNP cord-267475-6f4h3cck 179 3 al al NNP cord-267475-6f4h3cck 179 4 . . NNP cord-267475-6f4h3cck 179 5 , , , cord-267475-6f4h3cck 179 6 1991 1991 CD cord-267475-6f4h3cck 179 7 ; ; : cord-267475-6f4h3cck 179 8 Wu Wu NNP cord-267475-6f4h3cck 179 9 et et NNP cord-267475-6f4h3cck 179 10 al al NNP cord-267475-6f4h3cck 179 11 . . . cord-267475-6f4h3cck 180 1 , , , cord-267475-6f4h3cck 180 2 1993b 1993b CD cord-267475-6f4h3cck 180 3 ; ; : cord-267475-6f4h3cck 180 4 Zheng Zheng NNP cord-267475-6f4h3cck 180 5 et et NNP cord-267475-6f4h3cck 180 6 al al NNP cord-267475-6f4h3cck 180 7 . . NNP cord-267475-6f4h3cck 180 8 , , , cord-267475-6f4h3cck 180 9 1994 1994 CD cord-267475-6f4h3cck 180 10 ) ) -RRB- cord-267475-6f4h3cck 180 11 . . . cord-267475-6f4h3cck 181 1 b b LS cord-267475-6f4h3cck 181 2 In in IN cord-267475-6f4h3cck 181 3 these these DT cord-267475-6f4h3cck 181 4 cases case NNS cord-267475-6f4h3cck 181 5 , , , cord-267475-6f4h3cck 181 6 the the DT cord-267475-6f4h3cck 181 7 long long JJ cord-267475-6f4h3cck 181 8 and and CC cord-267475-6f4h3cck 181 9 short short JJ cord-267475-6f4h3cck 181 10 protein protein NN cord-267475-6f4h3cck 181 11 isoforms isoform NNS cord-267475-6f4h3cck 181 12 have have VBP cord-267475-6f4h3cck 181 13 different different JJ cord-267475-6f4h3cck 181 14 functional functional JJ cord-267475-6f4h3cck 181 15 effects effect NNS cord-267475-6f4h3cck 181 16 . . . cord-267475-6f4h3cck 182 1 Other other JJ cord-267475-6f4h3cck 182 2 genes gene NNS cord-267475-6f4h3cck 182 3 that that WDT cord-267475-6f4h3cck 182 4 resemble resemble VBP cord-267475-6f4h3cck 182 5 this this DT cord-267475-6f4h3cck 182 6 pattern pattern NN cord-267475-6f4h3cck 182 7 , , , cord-267475-6f4h3cck 182 8 producing produce VBG cord-267475-6f4h3cck 182 9 long long JJ cord-267475-6f4h3cck 182 10 and and CC cord-267475-6f4h3cck 182 11 short short JJ cord-267475-6f4h3cck 182 12 isoforms isoform NNS cord-267475-6f4h3cck 182 13 with with IN cord-267475-6f4h3cck 182 14 contrasting contrast VBG cord-267475-6f4h3cck 182 15 functions function NNS cord-267475-6f4h3cck 182 16 , , , cord-267475-6f4h3cck 182 17 are be VBP cord-267475-6f4h3cck 182 18 not not RB cord-267475-6f4h3cck 182 19 listed list VBN cord-267475-6f4h3cck 182 20 in in IN cord-267475-6f4h3cck 182 21 the the DT cord-267475-6f4h3cck 182 22 table table NN cord-267475-6f4h3cck 182 23 because because IN cord-267475-6f4h3cck 182 24 the the DT cord-267475-6f4h3cck 182 25 AUG AUG NNP cord-267475-6f4h3cck 182 26 START START NNP cord-267475-6f4h3cck 182 27 codon codon NN cord-267475-6f4h3cck 182 28 for for IN cord-267475-6f4h3cck 182 29 the the DT cord-267475-6f4h3cck 182 30 shorter short JJR cord-267475-6f4h3cck 182 31 protein protein NN cord-267475-6f4h3cck 182 32 is be VBZ cord-267475-6f4h3cck 182 33 carried carry VBN cord-267475-6f4h3cck 182 34 on on IN cord-267475-6f4h3cck 182 35 an an DT cord-267475-6f4h3cck 182 36 alternative alternative JJ cord-267475-6f4h3cck 182 37 exon exon NN cord-267475-6f4h3cck 182 38 present present JJ cord-267475-6f4h3cck 182 39 only only RB cord-267475-6f4h3cck 182 40 in in IN cord-267475-6f4h3cck 182 41 the the DT cord-267475-6f4h3cck 182 42 shorter short JJR cord-267475-6f4h3cck 182 43 mRNA mrna NN cord-267475-6f4h3cck 183 1 ( ( -LRB- cord-267475-6f4h3cck 183 2 e.g. e.g. IN cord-267475-6f4h3cck 183 3 Koski Koski NNP cord-267475-6f4h3cck 183 4 et et NNP cord-267475-6f4h3cck 183 5 al al NNP cord-267475-6f4h3cck 183 6 . . . cord-267475-6f4h3cck 184 1 , , , cord-267475-6f4h3cck 184 2 1999 1999 CD cord-267475-6f4h3cck 184 3 ; ; : cord-267475-6f4h3cck 184 4 Molina Molina NNP cord-267475-6f4h3cck 184 5 et et NNP cord-267475-6f4h3cck 184 6 al al NNP cord-267475-6f4h3cck 184 7 . . NNP cord-267475-6f4h3cck 184 8 , , , cord-267475-6f4h3cck 184 9 1993 1993 CD cord-267475-6f4h3cck 184 10 ) ) -RRB- cord-267475-6f4h3cck 184 11 . . . cord-267475-6f4h3cck 185 1 That that DT cord-267475-6f4h3cck 185 2 arrangement arrangement NN cord-267475-6f4h3cck 185 3 does do VBZ cord-267475-6f4h3cck 185 4 not not RB cord-267475-6f4h3cck 185 5 illustrate illustrate VB cord-267475-6f4h3cck 185 6 the the DT cord-267475-6f4h3cck 185 7 main main JJ cord-267475-6f4h3cck 185 8 point point NN cord-267475-6f4h3cck 185 9 of of IN cord-267475-6f4h3cck 185 10 the the DT cord-267475-6f4h3cck 185 11 table table NN cord-267475-6f4h3cck 185 12 , , , cord-267475-6f4h3cck 185 13 which which WDT cord-267475-6f4h3cck 185 14 is be VBZ cord-267475-6f4h3cck 185 15 that that IN cord-267475-6f4h3cck 185 16 a a DT cord-267475-6f4h3cck 185 17 silent silent JJ cord-267475-6f4h3cck 185 18 internal internal JJ cord-267475-6f4h3cck 185 19 AUG AUG NNP cord-267475-6f4h3cck 185 20 codon codon NN cord-267475-6f4h3cck 185 21 in in IN cord-267475-6f4h3cck 185 22 the the DT cord-267475-6f4h3cck 185 23 longer long JJR cord-267475-6f4h3cck 185 24 mRNA mrna NN cord-267475-6f4h3cck 185 25 can can MD cord-267475-6f4h3cck 185 26 be be VB cord-267475-6f4h3cck 185 27 activated activate VBN cord-267475-6f4h3cck 185 28 simply simply RB cord-267475-6f4h3cck 185 29 by by IN cord-267475-6f4h3cck 185 30 truncating truncate VBG cord-267475-6f4h3cck 185 31 the the DT cord-267475-6f4h3cck 185 32 transcript transcript NN cord-267475-6f4h3cck 185 33 . . . cord-267475-6f4h3cck 186 1 c c LS cord-267475-6f4h3cck 186 2 The the DT cord-267475-6f4h3cck 186 3 long long JJ cord-267475-6f4h3cck 186 4 and and CC cord-267475-6f4h3cck 186 5 short short JJ cord-267475-6f4h3cck 186 6 isoforms isoform NNS cord-267475-6f4h3cck 186 7 are be VBP cord-267475-6f4h3cck 186 8 targeted target VBN cord-267475-6f4h3cck 186 9 to to IN cord-267475-6f4h3cck 186 10 different different JJ cord-267475-6f4h3cck 186 11 cellular cellular JJ cord-267475-6f4h3cck 186 12 compartments compartment NNS cord-267475-6f4h3cck 186 13 . . . cord-267475-6f4h3cck 187 1 d d LS cord-267475-6f4h3cck 187 2 The the DT cord-267475-6f4h3cck 187 3 long long JJ cord-267475-6f4h3cck 187 4 and and CC cord-267475-6f4h3cck 187 5 short short JJ cord-267475-6f4h3cck 187 6 isoforms isoform NNS cord-267475-6f4h3cck 187 7 are be VBP cord-267475-6f4h3cck 187 8 expressed express VBN cord-267475-6f4h3cck 187 9 in in IN cord-267475-6f4h3cck 187 10 different different JJ cord-267475-6f4h3cck 187 11 tissues tissue NNS cord-267475-6f4h3cck 187 12 . . . cord-267475-6f4h3cck 188 1 e e LS cord-267475-6f4h3cck 189 1 The the DT cord-267475-6f4h3cck 189 2 long long JJ cord-267475-6f4h3cck 189 3 and and CC cord-267475-6f4h3cck 189 4 short short JJ cord-267475-6f4h3cck 189 5 forms form NNS cord-267475-6f4h3cck 189 6 of of IN cord-267475-6f4h3cck 189 7 b1,4-galactosyltransferase b1,4-galactosyltransferase NNP cord-267475-6f4h3cck 189 8 appear appear VB cord-267475-6f4h3cck 189 9 to to TO cord-267475-6f4h3cck 189 10 function function VB cord-267475-6f4h3cck 189 11 identically identically RB cord-267475-6f4h3cck 189 12 . . . cord-267475-6f4h3cck 190 1 The the DT cord-267475-6f4h3cck 190 2 main main JJ cord-267475-6f4h3cck 190 3 significance significance NN cord-267475-6f4h3cck 190 4 of of IN cord-267475-6f4h3cck 190 5 the the DT cord-267475-6f4h3cck 190 6 promoter promoter NN cord-267475-6f4h3cck 190 7 switch switch NN cord-267475-6f4h3cck 190 8 , , , cord-267475-6f4h3cck 190 9 which which WDT cord-267475-6f4h3cck 190 10 eliminates eliminate VBZ cord-267475-6f4h3cck 190 11 the the DT cord-267475-6f4h3cck 190 12 first first JJ cord-267475-6f4h3cck 190 13 AUG AUG NNP cord-267475-6f4h3cck 190 14 START START NNP cord-267475-6f4h3cck 190 15 codon codon NN cord-267475-6f4h3cck 190 16 , , , cord-267475-6f4h3cck 190 17 is be VBZ cord-267475-6f4h3cck 190 18 that that IN cord-267475-6f4h3cck 190 19 the the DT cord-267475-6f4h3cck 190 20 shorter short JJR cord-267475-6f4h3cck 190 21 5 5 CD cord-267475-6f4h3cck 190 22 0 0 CD cord-267475-6f4h3cck 191 1 UTR UTR NNP cord-267475-6f4h3cck 191 2 supports support VBZ cord-267475-6f4h3cck 191 3 translation translation NN cord-267475-6f4h3cck 191 4 more more RBR cord-267475-6f4h3cck 191 5 efficiently efficiently RB cord-267475-6f4h3cck 192 1 ( ( -LRB- cord-267475-6f4h3cck 192 2 Charron Charron NNP cord-267475-6f4h3cck 192 3 et et NNP cord-267475-6f4h3cck 192 4 al al NNP cord-267475-6f4h3cck 192 5 . . NNP cord-267475-6f4h3cck 192 6 , , , cord-267475-6f4h3cck 192 7 1998 1998 CD cord-267475-6f4h3cck 193 1 ( ( -LRB- cord-267475-6f4h3cck 193 2 Charron Charron NNP cord-267475-6f4h3cck 193 3 et et NNP cord-267475-6f4h3cck 193 4 al al NNP cord-267475-6f4h3cck 193 5 . . NNP cord-267475-6f4h3cck 193 6 , , , cord-267475-6f4h3cck 193 7 ) ) -RRB- cord-267475-6f4h3cck 193 8 . . . cord-267475-6f4h3cck 194 1 et et NNP cord-267475-6f4h3cck 194 2 al al NNP cord-267475-6f4h3cck 194 3 . . . cord-267475-6f4h3cck 195 1 , , , cord-267475-6f4h3cck 195 2 1999 1999 CD cord-267475-6f4h3cck 196 1 Calkhoven Calkhoven NNP cord-267475-6f4h3cck 196 2 et et NNP cord-267475-6f4h3cck 196 3 al al NNP cord-267475-6f4h3cck 196 4 . . NNP cord-267475-6f4h3cck 196 5 , , , cord-267475-6f4h3cck 196 6 2000 2000 CD cord-267475-6f4h3cck 197 1 ; ; : cord-267475-6f4h3cck 197 2 Spotts Spotts NNP cord-267475-6f4h3cck 197 3 et et NNP cord-267475-6f4h3cck 197 4 al al NNP cord-267475-6f4h3cck 197 5 . . NNP cord-267475-6f4h3cck 197 6 , , , cord-267475-6f4h3cck 197 7 1997 1997 CD cord-267475-6f4h3cck 197 8 ) ) -RRB- cord-267475-6f4h3cck 197 9 or or CC cord-267475-6f4h3cck 197 10 patterns pattern NNS cord-267475-6f4h3cck 197 11 of of IN cord-267475-6f4h3cck 197 12 localization localization NN cord-267475-6f4h3cck 197 13 ( ( -LRB- cord-267475-6f4h3cck 197 14 Acland Acland NNP cord-267475-6f4h3cck 197 15 et et NNP cord-267475-6f4h3cck 197 16 al al NNP cord-267475-6f4h3cck 197 17 . . NNP cord-267475-6f4h3cck 197 18 , , , cord-267475-6f4h3cck 197 19 1990 1990 CD cord-267475-6f4h3cck 197 20 ; ; : cord-267475-6f4h3cck 198 1 Lock Lock NNP cord-267475-6f4h3cck 198 2 et et FW cord-267475-6f4h3cck 198 3 al al NNP cord-267475-6f4h3cck 198 4 . . NNP cord-267475-6f4h3cck 198 5 , , , cord-267475-6f4h3cck 198 6 1991 1991 CD cord-267475-6f4h3cck 198 7 ; ; : cord-267475-6f4h3cck 198 8 Packham Packham NNP cord-267475-6f4h3cck 198 9 et et NNP cord-267475-6f4h3cck 198 10 al al NNP cord-267475-6f4h3cck 198 11 . . NNP cord-267475-6f4h3cck 198 12 , , , cord-267475-6f4h3cck 198 13 1997 1997 CD cord-267475-6f4h3cck 198 14 ) ) -RRB- cord-267475-6f4h3cck 198 15 , , , cord-267475-6f4h3cck 198 16 it -PRON- PRP cord-267475-6f4h3cck 198 17 would would MD cord-267475-6f4h3cck 198 18 not not RB cord-267475-6f4h3cck 198 19 be be VB cord-267475-6f4h3cck 198 20 surprising surprising JJ cord-267475-6f4h3cck 198 21 if if IN cord-267475-6f4h3cck 198 22 some some DT cord-267475-6f4h3cck 198 23 other other JJ cord-267475-6f4h3cck 198 24 upstream upstream RB cord-267475-6f4h3cck 198 25 - - HYPH cord-267475-6f4h3cck 198 26 initiated initiate VBN cord-267475-6f4h3cck 198 27 proteins protein NNS cord-267475-6f4h3cck 198 28 turn turn VBP cord-267475-6f4h3cck 198 29 out out RP cord-267475-6f4h3cck 198 30 to to TO cord-267475-6f4h3cck 198 31 be be VB cord-267475-6f4h3cck 198 32 inadvertent inadvertent JJ cord-267475-6f4h3cck 198 33 byproducts byproduct NNS cord-267475-6f4h3cck 198 34 generated generate VBN cord-267475-6f4h3cck 198 35 in in IN cord-267475-6f4h3cck 198 36 the the DT cord-267475-6f4h3cck 198 37 course course NN cord-267475-6f4h3cck 198 38 of of IN cord-267475-6f4h3cck 198 39 slowly slowly RB cord-267475-6f4h3cck 198 40 traversing traverse VBG cord-267475-6f4h3cck 198 41 a a DT cord-267475-6f4h3cck 198 42 GC gc NN cord-267475-6f4h3cck 198 43 - - HYPH cord-267475-6f4h3cck 198 44 rich rich JJ cord-267475-6f4h3cck 198 45 leader leader NN cord-267475-6f4h3cck 198 46 sequence sequence NN cord-267475-6f4h3cck 198 47 . . . cord-267475-6f4h3cck 199 1 Because because IN cord-267475-6f4h3cck 199 2 the the DT cord-267475-6f4h3cck 199 3 ability ability NN cord-267475-6f4h3cck 199 4 of of IN cord-267475-6f4h3cck 199 5 the the DT cord-267475-6f4h3cck 199 6 scanning scanning NN cord-267475-6f4h3cck 199 7 mechanism mechanism NN cord-267475-6f4h3cck 199 8 to to TO cord-267475-6f4h3cck 199 9 explain explain VB cord-267475-6f4h3cck 199 10 the the DT cord-267475-6f4h3cck 199 11 big big JJ cord-267475-6f4h3cck 199 12 picture picture NN cord-267475-6f4h3cck 199 13 is be VBZ cord-267475-6f4h3cck 199 14 generally generally RB cord-267475-6f4h3cck 199 15 accepted accept VBN cord-267475-6f4h3cck 199 16 , , , cord-267475-6f4h3cck 199 17 the the DT cord-267475-6f4h3cck 199 18 remainder remainder NN cord-267475-6f4h3cck 199 19 of of IN cord-267475-6f4h3cck 199 20 this this DT cord-267475-6f4h3cck 199 21 review review NN cord-267475-6f4h3cck 199 22 directs direct VBZ cord-267475-6f4h3cck 199 23 attention attention NN cord-267475-6f4h3cck 199 24 , , , cord-267475-6f4h3cck 199 25 not not RB cord-267475-6f4h3cck 199 26 to to IN cord-267475-6f4h3cck 199 27 examples example NNS cord-267475-6f4h3cck 199 28 that that WDT cord-267475-6f4h3cck 199 29 can can MD cord-267475-6f4h3cck 199 30 be be VB cord-267475-6f4h3cck 199 31 seen see VBN cord-267475-6f4h3cck 199 32 readily readily RB cord-267475-6f4h3cck 199 33 to to TO cord-267475-6f4h3cck 199 34 support support VB cord-267475-6f4h3cck 199 35 the the DT cord-267475-6f4h3cck 199 36 model model NN cord-267475-6f4h3cck 199 37 , , , cord-267475-6f4h3cck 199 38 but but CC cord-267475-6f4h3cck 199 39 to to IN cord-267475-6f4h3cck 199 40 mRNAs mrnas PRP cord-267475-6f4h3cck 199 41 that that WDT cord-267475-6f4h3cck 199 42 seem seem VBP cord-267475-6f4h3cck 199 43 to to TO cord-267475-6f4h3cck 199 44 be be VB cord-267475-6f4h3cck 199 45 poorly poorly RB cord-267475-6f4h3cck 199 46 designed design VBN cord-267475-6f4h3cck 199 47 for for IN cord-267475-6f4h3cck 199 48 a a DT cord-267475-6f4h3cck 199 49 scanning scanning NN cord-267475-6f4h3cck 199 50 mode mode NN cord-267475-6f4h3cck 199 51 of of IN cord-267475-6f4h3cck 199 52 initiation initiation NN cord-267475-6f4h3cck 199 53 . . . cord-267475-6f4h3cck 200 1 The the DT cord-267475-6f4h3cck 200 2 main main JJ cord-267475-6f4h3cck 200 3 point point NN cord-267475-6f4h3cck 200 4 is be VBZ cord-267475-6f4h3cck 200 5 that that IN cord-267475-6f4h3cck 200 6 the the DT cord-267475-6f4h3cck 200 7 scanning scanning NN cord-267475-6f4h3cck 200 8 mechanism mechanism NN cord-267475-6f4h3cck 200 9 applies apply VBZ cord-267475-6f4h3cck 200 10 even even RB cord-267475-6f4h3cck 200 11 in in IN cord-267475-6f4h3cck 200 12 these these DT cord-267475-6f4h3cck 200 13 difficult difficult JJ cord-267475-6f4h3cck 200 14 cases case NNS cord-267475-6f4h3cck 200 15 . . . cord-267475-6f4h3cck 201 1 Understandably understandably RB cord-267475-6f4h3cck 201 2 , , , cord-267475-6f4h3cck 201 3 such such JJ cord-267475-6f4h3cck 201 4 mRNAs mRNAs NNPS cord-267475-6f4h3cck 201 5 are be VBP cord-267475-6f4h3cck 201 6 translated translate VBN cord-267475-6f4h3cck 201 7 inefficiently inefficiently RB cord-267475-6f4h3cck 201 8 and and CC cord-267475-6f4h3cck 201 9 this this DT cord-267475-6f4h3cck 201 10 brings bring VBZ cord-267475-6f4h3cck 201 11 out out RP cord-267475-6f4h3cck 201 12 a a DT cord-267475-6f4h3cck 201 13 second second JJ cord-267475-6f4h3cck 201 14 important important JJ cord-267475-6f4h3cck 201 15 point point NN cord-267475-6f4h3cck 202 1 : : : cord-267475-6f4h3cck 202 2 some some DT cord-267475-6f4h3cck 202 3 critical critical JJ cord-267475-6f4h3cck 202 4 regulatory regulatory JJ cord-267475-6f4h3cck 202 5 genes gene NNS cord-267475-6f4h3cck 202 6 require require VBP cord-267475-6f4h3cck 202 7 protein protein NN cord-267475-6f4h3cck 202 8 synthesis synthesis NN cord-267475-6f4h3cck 202 9 to to TO cord-267475-6f4h3cck 202 10 be be VB cord-267475-6f4h3cck 202 11 inefficient inefficient JJ cord-267475-6f4h3cck 202 12 . . . cord-267475-6f4h3cck 203 1 An an DT cord-267475-6f4h3cck 203 2 earlier early JJR cord-267475-6f4h3cck 203 3 review review NN cord-267475-6f4h3cck 203 4 raised raise VBD cord-267475-6f4h3cck 203 5 awareness awareness NN cord-267475-6f4h3cck 203 6 that that WDT cord-267475-6f4h3cck 203 7 genes gene NNS cord-267475-6f4h3cck 203 8 that that WDT cord-267475-6f4h3cck 203 9 encode encode VBP cord-267475-6f4h3cck 203 10 potent potent JJ cord-267475-6f4h3cck 203 11 regulatory regulatory JJ cord-267475-6f4h3cck 203 12 proteins protein NNS cord-267475-6f4h3cck 203 13 -cytokines -cytokines CD cord-267475-6f4h3cck 203 14 , , , cord-267475-6f4h3cck 203 15 growth growth NN cord-267475-6f4h3cck 203 16 factors factor NNS cord-267475-6f4h3cck 203 17 , , , cord-267475-6f4h3cck 203 18 kinases kinase NNS cord-267475-6f4h3cck 203 19 , , , cord-267475-6f4h3cck 203 20 transcription transcription NN cord-267475-6f4h3cck 203 21 factors factor NNS cord-267475-6f4h3cck 203 22 -often -often : cord-267475-6f4h3cck 203 23 produce produce VBP cord-267475-6f4h3cck 203 24 mRNAs mrna NNS cord-267475-6f4h3cck 203 25 in in IN cord-267475-6f4h3cck 203 26 which which WDT cord-267475-6f4h3cck 203 27 the the DT cord-267475-6f4h3cck 203 28 5 5 CD cord-267475-6f4h3cck 203 29 0 0 CD cord-267475-6f4h3cck 203 30 leader leader NN cord-267475-6f4h3cck 203 31 sequence sequence NN cord-267475-6f4h3cck 203 32 is be VBZ cord-267475-6f4h3cck 203 33 GC gc NN cord-267475-6f4h3cck 203 34 - - HYPH cord-267475-6f4h3cck 203 35 rich rich JJ cord-267475-6f4h3cck 203 36 or or CC cord-267475-6f4h3cck 203 37 burdened burden VBN cord-267475-6f4h3cck 203 38 by by IN cord-267475-6f4h3cck 203 39 upstream upstream JJ cord-267475-6f4h3cck 203 40 AUG AUG NNP cord-267475-6f4h3cck 203 41 codons codon NNS cord-267475-6f4h3cck 203 42 ( ( -LRB- cord-267475-6f4h3cck 203 43 Kozak Kozak NNP cord-267475-6f4h3cck 203 44 , , , cord-267475-6f4h3cck 203 45 1991a 1991a CD cord-267475-6f4h3cck 203 46 ) ) -RRB- cord-267475-6f4h3cck 203 47 . . . cord-267475-6f4h3cck 204 1 Some some DT cord-267475-6f4h3cck 204 2 examples example NNS cord-267475-6f4h3cck 204 3 described describe VBN cord-267475-6f4h3cck 204 4 herein herein RB cord-267475-6f4h3cck 204 5 validate validate VBP cord-267475-6f4h3cck 204 6 the the DT cord-267475-6f4h3cck 204 7 prediction prediction NN cord-267475-6f4h3cck 204 8 that that IN cord-267475-6f4h3cck 204 9 these these DT cord-267475-6f4h3cck 204 10 encumbered encumber VBN cord-267475-6f4h3cck 204 11 5 5 CD cord-267475-6f4h3cck 204 12 0 0 CD cord-267475-6f4h3cck 204 13 sequences sequence NNS cord-267475-6f4h3cck 204 14 are be VBP cord-267475-6f4h3cck 204 15 nature nature NN cord-267475-6f4h3cck 204 16 's 's POS cord-267475-6f4h3cck 204 17 way way NN cord-267475-6f4h3cck 204 18 of of IN cord-267475-6f4h3cck 204 19 limiting limit VBG cord-267475-6f4h3cck 204 20 the the DT cord-267475-6f4h3cck 204 21 synthesis synthesis NN cord-267475-6f4h3cck 204 22 of of IN cord-267475-6f4h3cck 204 23 potent potent JJ cord-267475-6f4h3cck 204 24 proteins protein NNS cord-267475-6f4h3cck 204 25 that that WDT cord-267475-6f4h3cck 204 26 would would MD cord-267475-6f4h3cck 204 27 be be VB cord-267475-6f4h3cck 204 28 harmful harmful JJ cord-267475-6f4h3cck 204 29 if if IN cord-267475-6f4h3cck 204 30 overproduced overproduced JJ cord-267475-6f4h3cck 204 31 . . . cord-267475-6f4h3cck 205 1 I -PRON- PRP cord-267475-6f4h3cck 205 2 also also RB cord-267475-6f4h3cck 205 3 suggested suggest VBD cord-267475-6f4h3cck 205 4 in in IN cord-267475-6f4h3cck 205 5 earlier early JJR cord-267475-6f4h3cck 205 6 reviews review NNS cord-267475-6f4h3cck 205 7 that that WDT cord-267475-6f4h3cck 205 8 , , , cord-267475-6f4h3cck 205 9 when when WRB cord-267475-6f4h3cck 205 10 a a DT cord-267475-6f4h3cck 205 11 cDNA cdna NN cord-267475-6f4h3cck 205 12 sequence sequence NN cord-267475-6f4h3cck 205 13 has have VBZ cord-267475-6f4h3cck 205 14 so so RB cord-267475-6f4h3cck 205 15 many many JJ cord-267475-6f4h3cck 205 16 upstream upstream JJ cord-267475-6f4h3cck 205 17 AUG AUG NNP cord-267475-6f4h3cck 205 18 codons codon NNS cord-267475-6f4h3cck 205 19 as as IN cord-267475-6f4h3cck 205 20 to to TO cord-267475-6f4h3cck 205 21 challenge challenge VB cord-267475-6f4h3cck 205 22 the the DT cord-267475-6f4h3cck 205 23 applicability applicability NN cord-267475-6f4h3cck 205 24 of of IN cord-267475-6f4h3cck 205 25 the the DT cord-267475-6f4h3cck 205 26 scanning scanning NN cord-267475-6f4h3cck 205 27 mechanism mechanism NN cord-267475-6f4h3cck 205 28 , , , cord-267475-6f4h3cck 205 29 it -PRON- PRP cord-267475-6f4h3cck 205 30 is be VBZ cord-267475-6f4h3cck 205 31 wise wise JJ cord-267475-6f4h3cck 205 32 to to TO cord-267475-6f4h3cck 205 33 ask ask VB cord-267475-6f4h3cck 205 34 whether whether IN cord-267475-6f4h3cck 205 35 the the DT cord-267475-6f4h3cck 205 36 cDNA cdna NN cord-267475-6f4h3cck 205 37 correctly correctly RB cord-267475-6f4h3cck 205 38 reflects reflect VBZ cord-267475-6f4h3cck 205 39 the the DT cord-267475-6f4h3cck 205 40 structure structure NN cord-267475-6f4h3cck 205 41 of of IN cord-267475-6f4h3cck 205 42 the the DT cord-267475-6f4h3cck 205 43 mRNA mrna NN cord-267475-6f4h3cck 205 44 . . . cord-267475-6f4h3cck 206 1 That that DT cord-267475-6f4h3cck 206 2 advice advice NN cord-267475-6f4h3cck 206 3 is be VBZ cord-267475-6f4h3cck 206 4 not not RB cord-267475-6f4h3cck 206 5 changed change VBN cord-267475-6f4h3cck 206 6 by by IN cord-267475-6f4h3cck 206 7 what what WP cord-267475-6f4h3cck 206 8 is be VBZ cord-267475-6f4h3cck 206 9 written write VBN cord-267475-6f4h3cck 206 10 here here RB cord-267475-6f4h3cck 206 11 . . . cord-267475-6f4h3cck 207 1 Very very RB cord-267475-6f4h3cck 207 2 often often RB cord-267475-6f4h3cck 207 3 , , , cord-267475-6f4h3cck 207 4 cDNA cdna NN cord-267475-6f4h3cck 207 5 sequences sequence NNS cord-267475-6f4h3cck 207 6 that that WDT cord-267475-6f4h3cck 207 7 appear appear VBP cord-267475-6f4h3cck 207 8 incompatible incompatible JJ cord-267475-6f4h3cck 207 9 with with IN cord-267475-6f4h3cck 207 10 scanning scanning NN cord-267475-6f4h3cck 207 11 have have VBP cord-267475-6f4h3cck 207 12 been be VBN cord-267475-6f4h3cck 207 13 found find VBN cord-267475-6f4h3cck 207 14 to to TO cord-267475-6f4h3cck 207 15 derive derive VB cord-267475-6f4h3cck 207 16 from from IN cord-267475-6f4h3cck 207 17 incompletely incompletely RB cord-267475-6f4h3cck 207 18 spliced splice VBN cord-267475-6f4h3cck 207 19 transcripts transcript NNS cord-267475-6f4h3cck 207 20 or or CC cord-267475-6f4h3cck 207 21 to to TO cord-267475-6f4h3cck 207 22 have have VB cord-267475-6f4h3cck 207 23 been be VBN cord-267475-6f4h3cck 207 24 misinterpreted misinterpret VBN cord-267475-6f4h3cck 207 25 in in IN cord-267475-6f4h3cck 207 26 other other JJ cord-267475-6f4h3cck 207 27 ways way NNS cord-267475-6f4h3cck 207 28 ( ( -LRB- cord-267475-6f4h3cck 207 29 Kozak Kozak NNP cord-267475-6f4h3cck 207 30 , , , cord-267475-6f4h3cck 207 31 1996 1996 CD cord-267475-6f4h3cck 207 32 ( ( -LRB- cord-267475-6f4h3cck 207 33 Kozak Kozak NNP cord-267475-6f4h3cck 207 34 , , , cord-267475-6f4h3cck 207 35 , , , cord-267475-6f4h3cck 207 36 2000 2000 CD cord-267475-6f4h3cck 207 37 . . . cord-267475-6f4h3cck 208 1 In in IN cord-267475-6f4h3cck 208 2 other other JJ cord-267475-6f4h3cck 208 3 cases case NNS cord-267475-6f4h3cck 208 4 , , , cord-267475-6f4h3cck 208 5 although although IN cord-267475-6f4h3cck 208 6 an an DT cord-267475-6f4h3cck 208 7 encumbered encumber VBN cord-267475-6f4h3cck 208 8 cDNA cdna NN cord-267475-6f4h3cck 208 9 sequence sequence NN cord-267475-6f4h3cck 208 10 is be VBZ cord-267475-6f4h3cck 208 11 correct correct JJ cord-267475-6f4h3cck 208 12 , , , cord-267475-6f4h3cck 208 13 it -PRON- PRP cord-267475-6f4h3cck 208 14 derives derive VBZ cord-267475-6f4h3cck 208 15 from from IN cord-267475-6f4h3cck 208 16 a a DT cord-267475-6f4h3cck 208 17 transcript transcript NN cord-267475-6f4h3cck 208 18 that that WDT cord-267475-6f4h3cck 208 19 does do VBZ cord-267475-6f4h3cck 208 20 not not RB cord-267475-6f4h3cck 208 21 support support VB cord-267475-6f4h3cck 208 22 translation translation NN cord-267475-6f4h3cck 208 23 ( ( -LRB- cord-267475-6f4h3cck 208 24 Hake Hake NNP cord-267475-6f4h3cck 208 25 and and CC cord-267475-6f4h3cck 208 26 Hecht Hecht NNP cord-267475-6f4h3cck 208 27 , , , cord-267475-6f4h3cck 208 28 1993 1993 CD cord-267475-6f4h3cck 208 29 ; ; : cord-267475-6f4h3cck 208 30 Foo Foo NNP cord-267475-6f4h3cck 208 31 et et NNP cord-267475-6f4h3cck 208 32 al al NNP cord-267475-6f4h3cck 208 33 . . NNP cord-267475-6f4h3cck 208 34 , , , cord-267475-6f4h3cck 208 35 1994 1994 CD cord-267475-6f4h3cck 208 36 ; ; . cord-267475-6f4h3cck 209 1 Larsen Larsen NNP cord-267475-6f4h3cck 209 2 et et NNP cord-267475-6f4h3cck 209 3 al al NNP cord-267475-6f4h3cck 209 4 . . NNP cord-267475-6f4h3cck 209 5 , , , cord-267475-6f4h3cck 209 6 2002 2002 CD cord-267475-6f4h3cck 210 1 ; ; : cord-267475-6f4h3cck 210 2 Lee Lee NNP cord-267475-6f4h3cck 210 3 et et NNP cord-267475-6f4h3cck 210 4 al al NNP cord-267475-6f4h3cck 210 5 . . NNP cord-267475-6f4h3cck 210 6 , , , cord-267475-6f4h3cck 210 7 2000 2000 CD cord-267475-6f4h3cck 210 8 ) ) -RRB- cord-267475-6f4h3cck 210 9 . . . cord-267475-6f4h3cck 211 1 Only only RB cord-267475-6f4h3cck 211 2 after after IN cord-267475-6f4h3cck 211 3 one one CD cord-267475-6f4h3cck 211 4 is be VBZ cord-267475-6f4h3cck 211 5 certain certain JJ cord-267475-6f4h3cck 211 6 of of IN cord-267475-6f4h3cck 211 7 the the DT cord-267475-6f4h3cck 211 8 mRNA mRNA NNP cord-267475-6f4h3cck 211 9 structure structure NN cord-267475-6f4h3cck 211 10 should should MD cord-267475-6f4h3cck 211 11 the the DT cord-267475-6f4h3cck 211 12 mechanisms mechanism NNS cord-267475-6f4h3cck 211 13 below below RB cord-267475-6f4h3cck 211 14 be be VB cord-267475-6f4h3cck 211 15 considered consider VBN cord-267475-6f4h3cck 211 16 . . . cord-267475-6f4h3cck 212 1 In in IN cord-267475-6f4h3cck 212 2 mammals mammal NNS cord-267475-6f4h3cck 212 3 , , , cord-267475-6f4h3cck 212 4 the the DT cord-267475-6f4h3cck 212 5 optimal optimal JJ cord-267475-6f4h3cck 212 6 context context NN cord-267475-6f4h3cck 212 7 for for IN cord-267475-6f4h3cck 212 8 recognition recognition NN cord-267475-6f4h3cck 212 9 of of IN cord-267475-6f4h3cck 212 10 the the DT cord-267475-6f4h3cck 212 11 AUG AUG NNP cord-267475-6f4h3cck 212 12 START START NNP cord-267475-6f4h3cck 212 13 codon codon NN cord-267475-6f4h3cck 212 14 is be VBZ cord-267475-6f4h3cck 212 15 GCCRCCaugG. gccrccaugg. JJ cord-267475-6f4h3cck 212 16 Within within IN cord-267475-6f4h3cck 212 17 this this DT cord-267475-6f4h3cck 212 18 motif motif NN cord-267475-6f4h3cck 212 19 , , , cord-267475-6f4h3cck 212 20 the the DT cord-267475-6f4h3cck 212 21 purine purine NN cord-267475-6f4h3cck 212 22 ( ( -LRB- cord-267475-6f4h3cck 212 23 R r NN cord-267475-6f4h3cck 212 24 ) ) -RRB- cord-267475-6f4h3cck 212 25 in in IN cord-267475-6f4h3cck 212 26 position position NN cord-267475-6f4h3cck 212 27 23 23 CD cord-267475-6f4h3cck 212 28 is be VBZ cord-267475-6f4h3cck 212 29 the the DT cord-267475-6f4h3cck 212 30 most most RBS cord-267475-6f4h3cck 212 31 highly highly RB cord-267475-6f4h3cck 212 32 conserved conserved JJ cord-267475-6f4h3cck 212 33 ( ( -LRB- cord-267475-6f4h3cck 212 34 see see VB cord-267475-6f4h3cck 212 35 Section Section NNP cord-267475-6f4h3cck 212 36 6.1 6.1 CD cord-267475-6f4h3cck 212 37 ) ) -RRB- cord-267475-6f4h3cck 212 38 and and CC cord-267475-6f4h3cck 212 39 functionally functionally RB cord-267475-6f4h3cck 212 40 the the DT cord-267475-6f4h3cck 212 41 most most RBS cord-267475-6f4h3cck 212 42 important important JJ cord-267475-6f4h3cck 212 43 position position NN cord-267475-6f4h3cck 212 44 . . . cord-267475-6f4h3cck 213 1 The the DT cord-267475-6f4h3cck 213 2 importance importance NN cord-267475-6f4h3cck 213 3 of of IN cord-267475-6f4h3cck 213 4 A a NN cord-267475-6f4h3cck 213 5 or or CC cord-267475-6f4h3cck 213 6 G g NN cord-267475-6f4h3cck 213 7 ( ( -LRB- cord-267475-6f4h3cck 213 8 A a NN cord-267475-6f4h3cck 213 9 is be VBZ cord-267475-6f4h3cck 213 10 somewhat somewhat RB cord-267475-6f4h3cck 213 11 better well JJR cord-267475-6f4h3cck 213 12 than than IN cord-267475-6f4h3cck 213 13 G G NNP cord-267475-6f4h3cck 213 14 ) ) -RRB- cord-267475-6f4h3cck 213 15 in in IN cord-267475-6f4h3cck 213 16 position position NN cord-267475-6f4h3cck 213 17 2 2 CD cord-267475-6f4h3cck 213 18 3 3 CD cord-267475-6f4h3cck 213 19 was be VBD cord-267475-6f4h3cck 213 20 proved prove VBN cord-267475-6f4h3cck 213 21 by by IN cord-267475-6f4h3cck 213 22 mutagenesis mutagenesis NN cord-267475-6f4h3cck 213 23 experiments experiment NNS cord-267475-6f4h3cck 213 24 on on IN cord-267475-6f4h3cck 213 25 a a DT cord-267475-6f4h3cck 213 26 wide wide JJ cord-267475-6f4h3cck 213 27 variety variety NN cord-267475-6f4h3cck 213 28 of of IN cord-267475-6f4h3cck 213 29 genes gene NNS cord-267475-6f4h3cck 213 30 ( ( -LRB- cord-267475-6f4h3cck 213 31 Kozak Kozak NNP cord-267475-6f4h3cck 213 32 , , , cord-267475-6f4h3cck 213 33 1986b 1986b CD cord-267475-6f4h3cck 213 34 ; ; : cord-267475-6f4h3cck 213 35 _SP cord-267475-6f4h3cck 213 36 and and CC cord-267475-6f4h3cck 213 37 see see VB cord-267475-6f4h3cck 213 38 entries entry NNS cord-267475-6f4h3cck 213 39 marked mark VBD cord-267475-6f4h3cck 213 40 ' ' `` cord-267475-6f4h3cck 213 41 tested test VBN cord-267475-6f4h3cck 213 42 ' ' '' cord-267475-6f4h3cck 213 43 in in IN cord-267475-6f4h3cck 213 44 Table Table NNP cord-267475-6f4h3cck 213 45 3 3 CD cord-267475-6f4h3cck 213 46 ) ) -RRB- cord-267475-6f4h3cck 213 47 . . . cord-267475-6f4h3cck 214 1 The the DT cord-267475-6f4h3cck 214 2 G g NN cord-267475-6f4h3cck 214 3 in in IN cord-267475-6f4h3cck 214 4 position position NN cord-267475-6f4h3cck 215 1 þ þ LS cord-267475-6f4h3cck 215 2 4 4 CD cord-267475-6f4h3cck 215 3 is be VBZ cord-267475-6f4h3cck 215 4 also also RB cord-267475-6f4h3cck 215 5 highly highly RB cord-267475-6f4h3cck 215 6 conserved conserve VBN cord-267475-6f4h3cck 215 7 and and CC cord-267475-6f4h3cck 215 8 , , , cord-267475-6f4h3cck 215 9 especially especially RB cord-267475-6f4h3cck 215 10 in in IN cord-267475-6f4h3cck 215 11 the the DT cord-267475-6f4h3cck 215 12 absence absence NN cord-267475-6f4h3cck 215 13 of of IN cord-267475-6f4h3cck 215 14 A a DT cord-267475-6f4h3cck 215 15 in in IN cord-267475-6f4h3cck 215 16 position position NN cord-267475-6f4h3cck 215 17 2 2 CD cord-267475-6f4h3cck 215 18 3 3 CD cord-267475-6f4h3cck 215 19 , , , cord-267475-6f4h3cck 215 20 contributes contribute VBZ cord-267475-6f4h3cck 215 21 strongly strongly RB cord-267475-6f4h3cck 215 22 ( ( -LRB- cord-267475-6f4h3cck 215 23 Kozak Kozak NNP cord-267475-6f4h3cck 215 24 , , , cord-267475-6f4h3cck 215 25 1997 1997 CD cord-267475-6f4h3cck 215 26 ) ) -RRB- cord-267475-6f4h3cck 215 27 . . . cord-267475-6f4h3cck 216 1 Adherence adherence NN cord-267475-6f4h3cck 216 2 to to IN cord-267475-6f4h3cck 216 3 the the DT cord-267475-6f4h3cck 216 4 rest rest NN cord-267475-6f4h3cck 216 5 of of IN cord-267475-6f4h3cck 216 6 the the DT cord-267475-6f4h3cck 216 7 GCCRCCaugG gccrccaugg JJ cord-267475-6f4h3cck 216 8 motif motif NN cord-267475-6f4h3cck 216 9 varies vary VBZ cord-267475-6f4h3cck 216 10 , , , cord-267475-6f4h3cck 216 11 without without IN cord-267475-6f4h3cck 216 12 major major JJ cord-267475-6f4h3cck 216 13 consequences consequence NNS cord-267475-6f4h3cck 216 14 as as RB cord-267475-6f4h3cck 216 15 long long RB cord-267475-6f4h3cck 216 16 as as IN cord-267475-6f4h3cck 216 17 positions position NNS cord-267475-6f4h3cck 216 18 2 2 CD cord-267475-6f4h3cck 216 19 3 3 CD cord-267475-6f4h3cck 216 20 and and CC cord-267475-6f4h3cck 216 21 þ þ NN cord-267475-6f4h3cck 216 22 4 4 CD cord-267475-6f4h3cck 216 23 conform conform VBP cord-267475-6f4h3cck 216 24 ; ; : cord-267475-6f4h3cck 216 25 the the DT cord-267475-6f4h3cck 216 26 upstream upstream JJ cord-267475-6f4h3cck 216 27 GCC gcc NN cord-267475-6f4h3cck 216 28 motif motif NN cord-267475-6f4h3cck 216 29 can can MD cord-267475-6f4h3cck 216 30 be be VB cord-267475-6f4h3cck 216 31 seen see VBN cord-267475-6f4h3cck 216 32 to to TO cord-267475-6f4h3cck 216 33 contribute contribute VB cord-267475-6f4h3cck 216 34 , , , cord-267475-6f4h3cck 216 35 however however RB cord-267475-6f4h3cck 216 36 , , , cord-267475-6f4h3cck 216 37 in in IN cord-267475-6f4h3cck 216 38 the the DT cord-267475-6f4h3cck 216 39 absence absence NN cord-267475-6f4h3cck 216 40 of of IN cord-267475-6f4h3cck 216 41 other other JJ cord-267475-6f4h3cck 216 42 elements element NNS cord-267475-6f4h3cck 216 43 ( ( -LRB- cord-267475-6f4h3cck 216 44 Kozak Kozak NNP cord-267475-6f4h3cck 216 45 , , , cord-267475-6f4h3cck 216 46 1987b 1987b CD cord-267475-6f4h3cck 216 47 ) ) -RRB- cord-267475-6f4h3cck 216 48 . . . cord-267475-6f4h3cck 217 1 The the DT cord-267475-6f4h3cck 217 2 aforementioned aforementioned JJ cord-267475-6f4h3cck 217 3 mutagenesis mutagenesis NN cord-267475-6f4h3cck 217 4 experiments experiment NNS cord-267475-6f4h3cck 217 5 define define VBP cord-267475-6f4h3cck 217 6 two two CD cord-267475-6f4h3cck 217 7 extremes extreme NNS cord-267475-6f4h3cck 217 8 : : : cord-267475-6f4h3cck 217 9 ( ( -LRB- cord-267475-6f4h3cck 217 10 i i NN cord-267475-6f4h3cck 217 11 ) ) -RRB- cord-267475-6f4h3cck 217 12 when when WRB cord-267475-6f4h3cck 217 13 the the DT cord-267475-6f4h3cck 217 14 first first JJ cord-267475-6f4h3cck 217 15 AUG AUG NNP cord-267475-6f4h3cck 217 16 codon codon NN cord-267475-6f4h3cck 217 17 occurs occur VBZ cord-267475-6f4h3cck 217 18 in in IN cord-267475-6f4h3cck 217 19 a a DT cord-267475-6f4h3cck 217 20 strong strong JJ cord-267475-6f4h3cck 217 21 context context NN cord-267475-6f4h3cck 217 22 -ANNaugN -ANNaugN : cord-267475-6f4h3cck 217 23 or or CC cord-267475-6f4h3cck 217 24 GNNaugG GNNaugG NNPS cord-267475-6f4h3cck 217 25 -all -all : cord-267475-6f4h3cck 217 26 or or CC cord-267475-6f4h3cck 217 27 almost almost RB cord-267475-6f4h3cck 217 28 all all DT cord-267475-6f4h3cck 217 29 ribosomes ribosome NNS cord-267475-6f4h3cck 217 30 stop stop VBP cord-267475-6f4h3cck 217 31 and and CC cord-267475-6f4h3cck 217 32 initiate initiate VBP cord-267475-6f4h3cck 217 33 at at IN cord-267475-6f4h3cck 217 34 that that DT cord-267475-6f4h3cck 217 35 point point NN cord-267475-6f4h3cck 217 36 ; ; , cord-267475-6f4h3cck 217 37 ( ( -LRB- cord-267475-6f4h3cck 217 38 ii ii NN cord-267475-6f4h3cck 217 39 ) ) -RRB- cord-267475-6f4h3cck 217 40 when when WRB cord-267475-6f4h3cck 217 41 the the DT cord-267475-6f4h3cck 217 42 first first JJ cord-267475-6f4h3cck 217 43 AUG AUG NNP cord-267475-6f4h3cck 217 44 resides reside VBZ cord-267475-6f4h3cck 217 45 in in IN cord-267475-6f4h3cck 217 46 a a DT cord-267475-6f4h3cck 217 47 very very RB cord-267475-6f4h3cck 217 48 weak weak JJ cord-267475-6f4h3cck 217 49 context context NN cord-267475-6f4h3cck 217 50 , , , cord-267475-6f4h3cck 217 51 lacking lack VBG cord-267475-6f4h3cck 217 52 both both DT cord-267475-6f4h3cck 217 53 R r NN cord-267475-6f4h3cck 217 54 in in IN cord-267475-6f4h3cck 217 55 position position NN cord-267475-6f4h3cck 217 56 2 2 CD cord-267475-6f4h3cck 217 57 3 3 CD cord-267475-6f4h3cck 217 58 and and CC cord-267475-6f4h3cck 217 59 G g NN cord-267475-6f4h3cck 217 60 in in IN cord-267475-6f4h3cck 217 61 position position NN cord-267475-6f4h3cck 217 62 þ þ NNP cord-267475-6f4h3cck 217 63 4 4 CD cord-267475-6f4h3cck 217 64 , , , cord-267475-6f4h3cck 217 65 some some DT cord-267475-6f4h3cck 217 66 ribosomes ribosome NNS cord-267475-6f4h3cck 217 67 initiate initiate VBP cord-267475-6f4h3cck 217 68 at at IN cord-267475-6f4h3cck 217 69 that that DT cord-267475-6f4h3cck 217 70 point point NN cord-267475-6f4h3cck 217 71 but but CC cord-267475-6f4h3cck 217 72 most most JJS cord-267475-6f4h3cck 217 73 continue continue VBP cord-267475-6f4h3cck 217 74 scanning scan VBG cord-267475-6f4h3cck 217 75 and and CC cord-267475-6f4h3cck 217 76 initiate initiate VB cord-267475-6f4h3cck 217 77 farther farther RB cord-267475-6f4h3cck 217 78 downstream downstream RB cord-267475-6f4h3cck 217 79 . . . cord-267475-6f4h3cck 218 1 This this DT cord-267475-6f4h3cck 218 2 leaky leaky JJ cord-267475-6f4h3cck 218 3 scanning scanning NN cord-267475-6f4h3cck 218 4 enables enable VBZ cord-267475-6f4h3cck 218 5 the the DT cord-267475-6f4h3cck 218 6 production production NN cord-267475-6f4h3cck 218 7 of of IN cord-267475-6f4h3cck 218 8 two two CD cord-267475-6f4h3cck 218 9 separately separately RB cord-267475-6f4h3cck 218 10 initiated initiate VBN cord-267475-6f4h3cck 218 11 proteins protein NNS cord-267475-6f4h3cck 218 12 from from IN cord-267475-6f4h3cck 218 13 one one CD cord-267475-6f4h3cck 218 14 mRNA mrna NN cord-267475-6f4h3cck 218 15 , , , cord-267475-6f4h3cck 218 16 as as IN cord-267475-6f4h3cck 218 17 documented document VBN cord-267475-6f4h3cck 218 18 below below RB cord-267475-6f4h3cck 218 19 . . . cord-267475-6f4h3cck 219 1 It -PRON- PRP cord-267475-6f4h3cck 219 2 is be VBZ cord-267475-6f4h3cck 219 3 harder hard JJR cord-267475-6f4h3cck 219 4 to to TO cord-267475-6f4h3cck 219 5 predict predict VB cord-267475-6f4h3cck 219 6 what what WP cord-267475-6f4h3cck 219 7 happens happen VBZ cord-267475-6f4h3cck 219 8 at at IN cord-267475-6f4h3cck 219 9 start start NN cord-267475-6f4h3cck 219 10 sites site NNS cord-267475-6f4h3cck 219 11 that that WDT cord-267475-6f4h3cck 219 12 fall fall VBP cord-267475-6f4h3cck 219 13 between between IN cord-267475-6f4h3cck 219 14 the the DT cord-267475-6f4h3cck 219 15 extremes extreme NNS cord-267475-6f4h3cck 219 16 , , , cord-267475-6f4h3cck 219 17 i.e. i.e. FW cord-267475-6f4h3cck 219 18 mRNAs mrnas RB cord-267475-6f4h3cck 219 19 in in IN cord-267475-6f4h3cck 219 20 which which WDT cord-267475-6f4h3cck 219 21 the the DT cord-267475-6f4h3cck 219 22 first first JJ cord-267475-6f4h3cck 219 23 potential potential JJ cord-267475-6f4h3cck 219 24 start start NN cord-267475-6f4h3cck 219 25 codon codon NN cord-267475-6f4h3cck 219 26 has have VBZ cord-267475-6f4h3cck 219 27 the the DT cord-267475-6f4h3cck 219 28 sequence sequence NN cord-267475-6f4h3cck 219 29 YNNaugG ynnaugg NN cord-267475-6f4h3cck 219 30 , , , cord-267475-6f4h3cck 219 31 GNNaugY GNNaugY NNPS cord-267475-6f4h3cck 219 32 or or CC cord-267475-6f4h3cck 219 33 GNNaugA. GNNaugA. NNP cord-267475-6f4h3cck 219 34 Leaky leaky JJ cord-267475-6f4h3cck 219 35 scanning scanning NN cord-267475-6f4h3cck 219 36 is be VBZ cord-267475-6f4h3cck 219 37 seen see VBN cord-267475-6f4h3cck 219 38 in in IN cord-267475-6f4h3cck 219 39 some some DT cord-267475-6f4h3cck 219 40 but but CC cord-267475-6f4h3cck 219 41 not not RB cord-267475-6f4h3cck 219 42 all all DT cord-267475-6f4h3cck 219 43 such such JJ cord-267475-6f4h3cck 219 44 cases case NNS cord-267475-6f4h3cck 219 45 . . . cord-267475-6f4h3cck 220 1 A a DT cord-267475-6f4h3cck 220 2 possible possible JJ cord-267475-6f4h3cck 220 3 explanation explanation NN cord-267475-6f4h3cck 220 4 suggested suggest VBN cord-267475-6f4h3cck 220 5 by by IN cord-267475-6f4h3cck 220 6 studies study NNS cord-267475-6f4h3cck 220 7 with with IN cord-267475-6f4h3cck 220 8 test test NN cord-267475-6f4h3cck 220 9 transcripts transcript NNS cord-267475-6f4h3cck 220 10 ( ( -LRB- cord-267475-6f4h3cck 220 11 Kozak Kozak NNP cord-267475-6f4h3cck 220 12 , , , cord-267475-6f4h3cck 220 13 1990a 1990a CD cord-267475-6f4h3cck 220 14 ) ) -RRB- cord-267475-6f4h3cck 220 15 is be VBZ cord-267475-6f4h3cck 220 16 that that DT cord-267475-6f4h3cck 220 17 initiation initiation NN cord-267475-6f4h3cck 220 18 might may MD cord-267475-6f4h3cck 220 19 be be VB cord-267475-6f4h3cck 220 20 restricted restrict VBN cord-267475-6f4h3cck 220 21 to to IN cord-267475-6f4h3cck 220 22 the the DT cord-267475-6f4h3cck 220 23 first first JJ cord-267475-6f4h3cck 220 24 AUG AUG NNP cord-267475-6f4h3cck 220 25 codon codon NN cord-267475-6f4h3cck 220 26 , , , cord-267475-6f4h3cck 220 27 despite despite IN cord-267475-6f4h3cck 220 28 a a DT cord-267475-6f4h3cck 220 29 suboptimal suboptimal JJ cord-267475-6f4h3cck 220 30 context context NN cord-267475-6f4h3cck 220 31 , , , cord-267475-6f4h3cck 220 32 when when WRB cord-267475-6f4h3cck 220 33 downstream downstream JJ cord-267475-6f4h3cck 220 34 secondary secondary JJ cord-267475-6f4h3cck 220 35 structure structure NN cord-267475-6f4h3cck 220 36 slows slow VBZ cord-267475-6f4h3cck 220 37 scanning scan VBG cord-267475-6f4h3cck 220 38 and and CC cord-267475-6f4h3cck 220 39 thus thus RB cord-267475-6f4h3cck 220 40 provides provide VBZ cord-267475-6f4h3cck 220 41 more more JJR cord-267475-6f4h3cck 220 42 time time NN cord-267475-6f4h3cck 220 43 for for IN cord-267475-6f4h3cck 220 44 codon codon NN cord-267475-6f4h3cck 220 45 / / SYM cord-267475-6f4h3cck 220 46 anticodon anticodon NN cord-267475-6f4h3cck 220 47 pairing pairing NN cord-267475-6f4h3cck 220 48 . . . cord-267475-6f4h3cck 221 1 Suppression suppression NN cord-267475-6f4h3cck 221 2 of of IN cord-267475-6f4h3cck 221 3 leaky leaky JJ cord-267475-6f4h3cck 221 4 scanning scanning NN cord-267475-6f4h3cck 221 5 via via IN cord-267475-6f4h3cck 221 6 this this DT cord-267475-6f4h3cck 221 7 mechanism mechanism NN cord-267475-6f4h3cck 221 8 requires require VBZ cord-267475-6f4h3cck 221 9 a a DT cord-267475-6f4h3cck 221 10 critical critical JJ cord-267475-6f4h3cck 221 11 distance distance NN cord-267475-6f4h3cck 221 12 ( ( -LRB- cord-267475-6f4h3cck 221 13 13 13 CD cord-267475-6f4h3cck 221 14 -15 -15 NN cord-267475-6f4h3cck 221 15 nt nt RB cord-267475-6f4h3cck 221 16 , , , cord-267475-6f4h3cck 221 17 which which WDT cord-267475-6f4h3cck 221 18 corresponds correspond VBZ cord-267475-6f4h3cck 221 19 to to IN cord-267475-6f4h3cck 221 20 half half PDT cord-267475-6f4h3cck 221 21 the the DT cord-267475-6f4h3cck 221 22 diameter diameter NN cord-267475-6f4h3cck 221 23 of of IN cord-267475-6f4h3cck 221 24 the the DT cord-267475-6f4h3cck 221 25 ribosome ribosome NN cord-267475-6f4h3cck 221 26 ) ) -RRB- cord-267475-6f4h3cck 221 27 between between IN cord-267475-6f4h3cck 221 28 the the DT cord-267475-6f4h3cck 221 29 AUG AUG NNP cord-267475-6f4h3cck 221 30 codon codon NN cord-267475-6f4h3cck 221 31 and and CC cord-267475-6f4h3cck 221 32 the the DT cord-267475-6f4h3cck 221 33 downstream downstream JJ cord-267475-6f4h3cck 221 34 structured structured JJ cord-267475-6f4h3cck 221 35 element element NN cord-267475-6f4h3cck 221 36 . . . cord-267475-6f4h3cck 222 1 Table table NN cord-267475-6f4h3cck 222 2 3 3 CD cord-267475-6f4h3cck 222 3 lists list VBZ cord-267475-6f4h3cck 222 4 some some DT cord-267475-6f4h3cck 222 5 examples example NNS cord-267475-6f4h3cck 222 6 in in IN cord-267475-6f4h3cck 222 7 which which WDT cord-267475-6f4h3cck 222 8 two two CD cord-267475-6f4h3cck 222 9 proteins protein NNS cord-267475-6f4h3cck 222 10 are be VBP cord-267475-6f4h3cck 222 11 produced produce VBN cord-267475-6f4h3cck 222 12 from from IN cord-267475-6f4h3cck 222 13 one one CD cord-267475-6f4h3cck 222 14 mRNA mrna NN cord-267475-6f4h3cck 222 15 via via IN cord-267475-6f4h3cck 222 16 leaky leaky JJ cord-267475-6f4h3cck 222 17 scanning scanning NN cord-267475-6f4h3cck 222 18 . . . cord-267475-6f4h3cck 223 1 The the DT cord-267475-6f4h3cck 223 2 postulated postulate VBN cord-267475-6f4h3cck 223 3 link link NN cord-267475-6f4h3cck 223 4 between between IN cord-267475-6f4h3cck 223 5 context context NN cord-267475-6f4h3cck 223 6 and and CC cord-267475-6f4h3cck 223 7 leaky leaky JJ cord-267475-6f4h3cck 223 8 scanning scanning NN cord-267475-6f4h3cck 223 9 has have VBZ cord-267475-6f4h3cck 223 10 been be VBN cord-267475-6f4h3cck 223 11 tested test VBN cord-267475-6f4h3cck 223 12 in in IN cord-267475-6f4h3cck 223 13 many many JJ cord-267475-6f4h3cck 223 14 of of IN cord-267475-6f4h3cck 223 15 these these DT cord-267475-6f4h3cck 223 16 cases case NNS cord-267475-6f4h3cck 223 17 by by IN cord-267475-6f4h3cck 223 18 showing show VBG cord-267475-6f4h3cck 223 19 that that IN cord-267475-6f4h3cck 223 20 , , , cord-267475-6f4h3cck 223 21 upon upon IN cord-267475-6f4h3cck 223 22 improving improve VBG cord-267475-6f4h3cck 223 23 the the DT cord-267475-6f4h3cck 223 24 context context NN cord-267475-6f4h3cck 223 25 at at IN cord-267475-6f4h3cck 223 26 the the DT cord-267475-6f4h3cck 223 27 upstream upstream JJ cord-267475-6f4h3cck 223 28 site site NN cord-267475-6f4h3cck 223 29 , , , cord-267475-6f4h3cck 223 30 initiation initiation NN cord-267475-6f4h3cck 223 31 from from IN cord-267475-6f4h3cck 223 32 the the DT cord-267475-6f4h3cck 223 33 second second JJ cord-267475-6f4h3cck 223 34 site site NN cord-267475-6f4h3cck 223 35 is be VBZ cord-267475-6f4h3cck 223 36 reduced reduce VBN cord-267475-6f4h3cck 223 37 or or CC cord-267475-6f4h3cck 223 38 abolished abolish VBN cord-267475-6f4h3cck 223 39 . . . cord-267475-6f4h3cck 224 1 ( ( -LRB- cord-267475-6f4h3cck 224 2 Whether whether IN cord-267475-6f4h3cck 224 3 the the DT cord-267475-6f4h3cck 224 4 second second JJ cord-267475-6f4h3cck 224 5 AUG AUG NNP cord-267475-6f4h3cck 224 6 codon codon NN cord-267475-6f4h3cck 224 7 resides reside VBZ cord-267475-6f4h3cck 224 8 in in IN cord-267475-6f4h3cck 224 9 a a DT cord-267475-6f4h3cck 224 10 strong strong JJ cord-267475-6f4h3cck 224 11 or or CC cord-267475-6f4h3cck 224 12 weak weak JJ cord-267475-6f4h3cck 224 13 context context NN cord-267475-6f4h3cck 224 14 is be VBZ cord-267475-6f4h3cck 224 15 not not RB cord-267475-6f4h3cck 224 16 relevant relevant JJ cord-267475-6f4h3cck 224 17 ; ; : cord-267475-6f4h3cck 224 18 the the DT cord-267475-6f4h3cck 224 19 ribosome ribosome NN cord-267475-6f4h3cck 224 20 reads read VBZ cord-267475-6f4h3cck 224 21 the the DT cord-267475-6f4h3cck 224 22 mRNA mrna NN cord-267475-6f4h3cck 224 23 linearly linearly RB cord-267475-6f4h3cck 224 24 and and CC cord-267475-6f4h3cck 224 25 thus thus RB cord-267475-6f4h3cck 224 26 the the DT cord-267475-6f4h3cck 224 27 decision decision NN cord-267475-6f4h3cck 224 28 to to TO cord-267475-6f4h3cck 224 29 stop stop VB cord-267475-6f4h3cck 224 30 or or CC cord-267475-6f4h3cck 224 31 to to TO cord-267475-6f4h3cck 224 32 bypass bypass VB cord-267475-6f4h3cck 224 33 the the DT cord-267475-6f4h3cck 224 34 first first JJ cord-267475-6f4h3cck 224 35 AUG AUG NNP cord-267475-6f4h3cck 224 36 is be VBZ cord-267475-6f4h3cck 224 37 not not RB cord-267475-6f4h3cck 224 38 influenced influence VBN cord-267475-6f4h3cck 224 39 by by IN cord-267475-6f4h3cck 224 40 whether whether IN cord-267475-6f4h3cck 224 41 there there EX cord-267475-6f4h3cck 224 42 is be VBZ cord-267475-6f4h3cck 224 43 a a DT cord-267475-6f4h3cck 224 44 better well JJR cord-267475-6f4h3cck 224 45 initiation initiation NN cord-267475-6f4h3cck 224 46 site site NN cord-267475-6f4h3cck 224 47 downstream downstream RB cord-267475-6f4h3cck 224 48 . . . cord-267475-6f4h3cck 224 49 ) ) -RRB- cord-267475-6f4h3cck 225 1 The the DT cord-267475-6f4h3cck 225 2 large large JJ cord-267475-6f4h3cck 225 3 number number NN cord-267475-6f4h3cck 225 4 of of IN cord-267475-6f4h3cck 225 5 genes gene NNS cord-267475-6f4h3cck 225 6 that that WDT cord-267475-6f4h3cck 225 7 employ employ VBP cord-267475-6f4h3cck 225 8 leaky leaky JJ cord-267475-6f4h3cck 225 9 scanning scanning NN cord-267475-6f4h3cck 225 10 precludes preclude VBZ cord-267475-6f4h3cck 225 11 discussion discussion NN cord-267475-6f4h3cck 225 12 of of IN cord-267475-6f4h3cck 225 13 the the DT cord-267475-6f4h3cck 225 14 biological biological JJ cord-267475-6f4h3cck 225 15 significance significance NN cord-267475-6f4h3cck 225 16 of of IN cord-267475-6f4h3cck 225 17 the the DT cord-267475-6f4h3cck 225 18 proteins protein NNS cord-267475-6f4h3cck 225 19 thereby thereby RB cord-267475-6f4h3cck 225 20 produced produce VBN cord-267475-6f4h3cck 225 21 , , , cord-267475-6f4h3cck 225 22 but but CC cord-267475-6f4h3cck 225 23 it -PRON- PRP cord-267475-6f4h3cck 225 24 merits merit VBZ cord-267475-6f4h3cck 225 25 noting note VBG cord-267475-6f4h3cck 225 26 that that IN cord-267475-6f4h3cck 225 27 , , , cord-267475-6f4h3cck 225 28 for for IN cord-267475-6f4h3cck 225 29 many many JJ cord-267475-6f4h3cck 225 30 of of IN cord-267475-6f4h3cck 225 31 the the DT cord-267475-6f4h3cck 225 32 viruses virus NNS cord-267475-6f4h3cck 225 33 in in IN cord-267475-6f4h3cck 225 34 Table Table NNP cord-267475-6f4h3cck 225 35 3 3 CD cord-267475-6f4h3cck 225 36 , , , cord-267475-6f4h3cck 225 37 replication replication NN cord-267475-6f4h3cck 225 38 requires require VBZ cord-267475-6f4h3cck 225 39 production production NN cord-267475-6f4h3cck 225 40 of of IN cord-267475-6f4h3cck 225 41 both both DT cord-267475-6f4h3cck 225 42 listed list VBN cord-267475-6f4h3cck 225 43 proteins protein NNS cord-267475-6f4h3cck 225 44 . . . cord-267475-6f4h3cck 226 1 For for IN cord-267475-6f4h3cck 226 2 some some DT cord-267475-6f4h3cck 226 3 other other JJ cord-267475-6f4h3cck 226 4 viruses virus NNS cord-267475-6f4h3cck 226 5 , , , cord-267475-6f4h3cck 226 6 the the DT cord-267475-6f4h3cck 226 7 second second JJ cord-267475-6f4h3cck 226 8 protein protein NN cord-267475-6f4h3cck 226 9 is be VBZ cord-267475-6f4h3cck 226 10 a a DT cord-267475-6f4h3cck 226 11 virulence virulence NN cord-267475-6f4h3cck 226 12 factor factor NN cord-267475-6f4h3cck 226 13 that that WDT cord-267475-6f4h3cck 226 14 weakens weaken VBZ cord-267475-6f4h3cck 226 15 host host NN cord-267475-6f4h3cck 226 16 defenses defense NNS cord-267475-6f4h3cck 227 1 ( ( -LRB- cord-267475-6f4h3cck 227 2 Bridgen Bridgen NNP cord-267475-6f4h3cck 227 3 et et NNP cord-267475-6f4h3cck 227 4 al al NNP cord-267475-6f4h3cck 227 5 . . . cord-267475-6f4h3cck 228 1 , , , cord-267475-6f4h3cck 228 2 2001 2001 CD cord-267475-6f4h3cck 228 3 ; ; : cord-267475-6f4h3cck 228 4 Chen Chen NNP cord-267475-6f4h3cck 228 5 et et NNP cord-267475-6f4h3cck 228 6 al al NNP cord-267475-6f4h3cck 228 7 . . NNP cord-267475-6f4h3cck 228 8 , , , cord-267475-6f4h3cck 228 9 2001 2001 CD cord-267475-6f4h3cck 228 10 ; ; : cord-267475-6f4h3cck 228 11 Weber Weber NNP cord-267475-6f4h3cck 228 12 et et NNP cord-267475-6f4h3cck 228 13 al al NNP cord-267475-6f4h3cck 228 14 . . NNP cord-267475-6f4h3cck 228 15 , , , cord-267475-6f4h3cck 228 16 2002 2002 CD cord-267475-6f4h3cck 228 17 ) ) -RRB- cord-267475-6f4h3cck 228 18 . . . cord-267475-6f4h3cck 229 1 The the DT cord-267475-6f4h3cck 229 2 biological biological JJ cord-267475-6f4h3cck 229 3 importance importance NN cord-267475-6f4h3cck 229 4 of of IN cord-267475-6f4h3cck 229 5 these these DT cord-267475-6f4h3cck 229 6 downstream downstream RB cord-267475-6f4h3cck 229 7 - - HYPH cord-267475-6f4h3cck 229 8 initiated initiate VBN cord-267475-6f4h3cck 229 9 proteins protein NNS cord-267475-6f4h3cck 229 10 shows show VBZ cord-267475-6f4h3cck 229 11 that that IN cord-267475-6f4h3cck 229 12 leaky leaky JJ cord-267475-6f4h3cck 229 13 scanning scanning NN cord-267475-6f4h3cck 229 14 is be VBZ cord-267475-6f4h3cck 229 15 a a DT cord-267475-6f4h3cck 229 16 deliberately deliberately RB cord-267475-6f4h3cck 229 17 employed employ VBN cord-267475-6f4h3cck 229 18 tool tool NN cord-267475-6f4h3cck 229 19 ; ; : cord-267475-6f4h3cck 229 20 it -PRON- PRP cord-267475-6f4h3cck 229 21 does do VBZ cord-267475-6f4h3cck 229 22 not not RB cord-267475-6f4h3cck 229 23 simply simply RB cord-267475-6f4h3cck 229 24 reflect reflect VB cord-267475-6f4h3cck 229 25 sloppiness sloppiness NN cord-267475-6f4h3cck 229 26 on on IN cord-267475-6f4h3cck 229 27 the the DT cord-267475-6f4h3cck 229 28 part part NN cord-267475-6f4h3cck 229 29 of of IN cord-267475-6f4h3cck 229 30 the the DT cord-267475-6f4h3cck 229 31 translational translational JJ cord-267475-6f4h3cck 229 32 machinery machinery NN cord-267475-6f4h3cck 229 33 . . . cord-267475-6f4h3cck 230 1 The the DT cord-267475-6f4h3cck 230 2 long long JJ cord-267475-6f4h3cck 230 3 list list NN cord-267475-6f4h3cck 230 4 of of IN cord-267475-6f4h3cck 230 5 examples example NNS cord-267475-6f4h3cck 230 6 in in IN cord-267475-6f4h3cck 230 7 Table Table NNP cord-267475-6f4h3cck 230 8 3 3 CD cord-267475-6f4h3cck 230 9 conforms conform VBZ cord-267475-6f4h3cck 230 10 to to IN cord-267475-6f4h3cck 230 11 expectations expectation NNS cord-267475-6f4h3cck 230 12 in in IN cord-267475-6f4h3cck 230 13 that that IN cord-267475-6f4h3cck 230 14 the the DT cord-267475-6f4h3cck 230 15 first first JJ cord-267475-6f4h3cck 230 16 start start NN cord-267475-6f4h3cck 230 17 codon codon NN cord-267475-6f4h3cck 230 18 resides reside VBZ cord-267475-6f4h3cck 230 19 in in IN cord-267475-6f4h3cck 230 20 a a DT cord-267475-6f4h3cck 230 21 suboptimal suboptimal JJ cord-267475-6f4h3cck 230 22 context context NN cord-267475-6f4h3cck 230 23 . . . cord-267475-6f4h3cck 231 1 There there EX cord-267475-6f4h3cck 231 2 are be VBP cord-267475-6f4h3cck 231 3 , , , cord-267475-6f4h3cck 231 4 however however RB cord-267475-6f4h3cck 231 5 , , , cord-267475-6f4h3cck 231 6 rare rare JJ cord-267475-6f4h3cck 231 7 instances instance NNS cord-267475-6f4h3cck 231 8 of of IN cord-267475-6f4h3cck 231 9 leaky leaky JJ cord-267475-6f4h3cck 231 10 scanning scanning NN cord-267475-6f4h3cck 231 11 despite despite IN cord-267475-6f4h3cck 231 12 a a DT cord-267475-6f4h3cck 231 13 good good JJ cord-267475-6f4h3cck 231 14 context context NN cord-267475-6f4h3cck 231 15 ( ( -LRB- cord-267475-6f4h3cck 231 16 R R NNP cord-267475-6f4h3cck 231 17 23 23 CD cord-267475-6f4h3cck 231 18 and and CC cord-267475-6f4h3cck 231 19 G g NN cord-267475-6f4h3cck 231 20 þ4 þ4 NNP cord-267475-6f4h3cck 231 21 ) ) -RRB- cord-267475-6f4h3cck 231 22 around around IN cord-267475-6f4h3cck 231 23 the the DT cord-267475-6f4h3cck 231 24 first first JJ cord-267475-6f4h3cck 231 25 AUG AUG NNP cord-267475-6f4h3cck 231 26 . . . cord-267475-6f4h3cck 232 1 This this DT cord-267475-6f4h3cck 232 2 can can MD cord-267475-6f4h3cck 232 3 happen happen VB cord-267475-6f4h3cck 232 4 when when WRB cord-267475-6f4h3cck 232 5 the the DT cord-267475-6f4h3cck 232 6 first first JJ cord-267475-6f4h3cck 232 7 AUG AUG NNP cord-267475-6f4h3cck 232 8 codon codon NN cord-267475-6f4h3cck 232 9 is be VBZ cord-267475-6f4h3cck 232 10 too too RB cord-267475-6f4h3cck 232 11 close close JJ cord-267475-6f4h3cck 232 12 to to IN cord-267475-6f4h3cck 232 13 the the DT cord-267475-6f4h3cck 232 14 5 5 CD cord-267475-6f4h3cck 232 15 0 0 CD cord-267475-6f4h3cck 232 16 end end NN cord-267475-6f4h3cck 232 17 to to TO cord-267475-6f4h3cck 232 18 be be VB cord-267475-6f4h3cck 232 19 recognized recognize VBN cord-267475-6f4h3cck 232 20 efficiently efficiently RB cord-267475-6f4h3cck 233 1 ( ( -LRB- cord-267475-6f4h3cck 233 2 Kaneda Kaneda NNP cord-267475-6f4h3cck 233 3 et et NNP cord-267475-6f4h3cck 233 4 al al NNP cord-267475-6f4h3cck 233 5 . . NNP cord-267475-6f4h3cck 233 6 , , , cord-267475-6f4h3cck 233 7 2000 2000 CD cord-267475-6f4h3cck 233 8 ; ; : cord-267475-6f4h3cck 233 9 Kozak Kozak NNP cord-267475-6f4h3cck 233 10 , , , cord-267475-6f4h3cck 233 11 1991c 1991c CD cord-267475-6f4h3cck 233 12 ; ; : cord-267475-6f4h3cck 233 13 Ruan Ruan NNP cord-267475-6f4h3cck 233 14 et et NNP cord-267475-6f4h3cck 233 15 al al NNP cord-267475-6f4h3cck 233 16 . . NNP cord-267475-6f4h3cck 233 17 , , , cord-267475-6f4h3cck 233 18 1994 1994 CD cord-267475-6f4h3cck 233 19 ; ; : cord-267475-6f4h3cck 233 20 Sedman Sedman NNP cord-267475-6f4h3cck 233 21 et et FW cord-267475-6f4h3cck 233 22 al al NNP cord-267475-6f4h3cck 233 23 . . NNP cord-267475-6f4h3cck 233 24 , , , cord-267475-6f4h3cck 233 25 1990 1990 CD cord-267475-6f4h3cck 233 26 ; ; : cord-267475-6f4h3cck 234 1 Slusher Slusher NNP cord-267475-6f4h3cck 234 2 et et NNP cord-267475-6f4h3cck 234 3 al al NNP cord-267475-6f4h3cck 234 4 . . NNP cord-267475-6f4h3cck 234 5 , , , cord-267475-6f4h3cck 234 6 1991 1991 CD cord-267475-6f4h3cck 235 1 ; ; : cord-267475-6f4h3cck 235 2 Spiropoulou Spiropoulou NNP cord-267475-6f4h3cck 235 3 and and CC cord-267475-6f4h3cck 235 4 In in IN cord-267475-6f4h3cck 235 5 all all DT cord-267475-6f4h3cck 235 6 mRNAs mrnas CD cord-267475-6f4h3cck 235 7 here here RB cord-267475-6f4h3cck 235 8 listed list VBN cord-267475-6f4h3cck 235 9 , , , cord-267475-6f4h3cck 235 10 the the DT cord-267475-6f4h3cck 235 11 sequence sequence NN cord-267475-6f4h3cck 235 12 flanking flank VBG cord-267475-6f4h3cck 235 13 the the DT cord-267475-6f4h3cck 235 14 first first JJ cord-267475-6f4h3cck 235 15 start start NN cord-267475-6f4h3cck 235 16 codon codon NN cord-267475-6f4h3cck 235 17 deviates deviate VBZ cord-267475-6f4h3cck 235 18 from from IN cord-267475-6f4h3cck 235 19 the the DT cord-267475-6f4h3cck 235 20 consensus consensus NN cord-267475-6f4h3cck 235 21 sequence sequence NN cord-267475-6f4h3cck 235 22 in in IN cord-267475-6f4h3cck 235 23 position position NN cord-267475-6f4h3cck 235 24 23 23 CD cord-267475-6f4h3cck 235 25 and/or and/or CC cord-267475-6f4h3cck 235 26 position position NN cord-267475-6f4h3cck 235 27 þ þ NNP cord-267475-6f4h3cck 235 28 4 4 CD cord-267475-6f4h3cck 235 29 , , , cord-267475-6f4h3cck 235 30 highlighted highlight VBN cord-267475-6f4h3cck 235 31 by by IN cord-267475-6f4h3cck 235 32 underlining underline VBG cord-267475-6f4h3cck 235 33 . . . cord-267475-6f4h3cck 236 1 When when WRB cord-267475-6f4h3cck 236 2 the the DT cord-267475-6f4h3cck 236 3 postulated postulate VBN cord-267475-6f4h3cck 236 4 link link NN cord-267475-6f4h3cck 236 5 between between IN cord-267475-6f4h3cck 236 6 context context NN cord-267475-6f4h3cck 236 7 and and CC cord-267475-6f4h3cck 236 8 leaky leaky JJ cord-267475-6f4h3cck 236 9 scanning scanning NN cord-267475-6f4h3cck 236 10 was be VBD cord-267475-6f4h3cck 236 11 tested test VBN cord-267475-6f4h3cck 236 12 ( ( -LRB- cord-267475-6f4h3cck 236 13 so so RB cord-267475-6f4h3cck 236 14 marked mark VBN cord-267475-6f4h3cck 236 15 in in IN cord-267475-6f4h3cck 236 16 this this DT cord-267475-6f4h3cck 236 17 column column NN cord-267475-6f4h3cck 236 18 ) ) -RRB- cord-267475-6f4h3cck 236 19 , , , cord-267475-6f4h3cck 236 20 mutations mutation NNS cord-267475-6f4h3cck 236 21 that that WDT cord-267475-6f4h3cck 236 22 improved improve VBD cord-267475-6f4h3cck 236 23 the the DT cord-267475-6f4h3cck 236 24 context context NN cord-267475-6f4h3cck 236 25 at at IN cord-267475-6f4h3cck 236 26 the the DT cord-267475-6f4h3cck 236 27 first first JJ cord-267475-6f4h3cck 236 28 start start NN cord-267475-6f4h3cck 236 29 site site NN cord-267475-6f4h3cck 236 30 diminished diminish VBD cord-267475-6f4h3cck 236 31 access access NN cord-267475-6f4h3cck 236 32 to to IN cord-267475-6f4h3cck 236 33 the the DT cord-267475-6f4h3cck 236 34 downstream downstream JJ cord-267475-6f4h3cck 236 35 start start NN cord-267475-6f4h3cck 236 36 site site NN cord-267475-6f4h3cck 236 37 . . . cord-267475-6f4h3cck 237 1 This this DT cord-267475-6f4h3cck 237 2 test test NN cord-267475-6f4h3cck 237 3 failed fail VBD cord-267475-6f4h3cck 237 4 only only RB cord-267475-6f4h3cck 237 5 with with IN cord-267475-6f4h3cck 237 6 cucumber cucumber NN cord-267475-6f4h3cck 237 7 necrosis necrosis NN cord-267475-6f4h3cck 237 8 virus virus NN cord-267475-6f4h3cck 237 9 , , , cord-267475-6f4h3cck 237 10 where where WRB cord-267475-6f4h3cck 237 11 the the DT cord-267475-6f4h3cck 237 12 short short JJ cord-267475-6f4h3cck 237 13 distance distance NN cord-267475-6f4h3cck 237 14 between between IN cord-267475-6f4h3cck 237 15 the the DT cord-267475-6f4h3cck 237 16 m7 m7 NN cord-267475-6f4h3cck 237 17 G g NN cord-267475-6f4h3cck 237 18 cap cap NN cord-267475-6f4h3cck 237 19 and and CC cord-267475-6f4h3cck 237 20 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 237 21 allowed allow VBD cord-267475-6f4h3cck 237 22 some some DT cord-267475-6f4h3cck 237 23 leaky leaky JJ cord-267475-6f4h3cck 237 24 scanning scanning NN cord-267475-6f4h3cck 237 25 even even RB cord-267475-6f4h3cck 237 26 when when WRB cord-267475-6f4h3cck 237 27 the the DT cord-267475-6f4h3cck 237 28 context context NN cord-267475-6f4h3cck 237 29 was be VBD cord-267475-6f4h3cck 237 30 optimized optimize VBN cord-267475-6f4h3cck 237 31 . . . cord-267475-6f4h3cck 238 1 c c LS cord-267475-6f4h3cck 238 2 In in IN cord-267475-6f4h3cck 238 3 some some DT cord-267475-6f4h3cck 238 4 cases case NNS cord-267475-6f4h3cck 239 1 the the DT cord-267475-6f4h3cck 239 2 first first JJ cord-267475-6f4h3cck 239 3 and and CC cord-267475-6f4h3cck 239 4 second second JJ cord-267475-6f4h3cck 239 5 AUG AUG NNP cord-267475-6f4h3cck 239 6 codons codon NNS cord-267475-6f4h3cck 239 7 are be VBP cord-267475-6f4h3cck 239 8 in in IN cord-267475-6f4h3cck 239 9 the the DT cord-267475-6f4h3cck 239 10 same same JJ cord-267475-6f4h3cck 239 11 reading reading NN cord-267475-6f4h3cck 239 12 frame frame NN cord-267475-6f4h3cck 239 13 , , , cord-267475-6f4h3cck 239 14 generating generate VBG cord-267475-6f4h3cck 239 15 long long JJ cord-267475-6f4h3cck 239 16 and and CC cord-267475-6f4h3cck 239 17 short short JJ cord-267475-6f4h3cck 239 18 versions version NNS cord-267475-6f4h3cck 239 19 of of IN cord-267475-6f4h3cck 239 20 the the DT cord-267475-6f4h3cck 239 21 encoded encode VBN cord-267475-6f4h3cck 239 22 protein protein NN cord-267475-6f4h3cck 239 23 which which WDT cord-267475-6f4h3cck 239 24 may may MD cord-267475-6f4h3cck 239 25 function function VB cord-267475-6f4h3cck 239 26 differently differently RB cord-267475-6f4h3cck 239 27 . . . cord-267475-6f4h3cck 240 1 In in IN cord-267475-6f4h3cck 240 2 cases case NNS cord-267475-6f4h3cck 240 3 where where WRB cord-267475-6f4h3cck 240 4 the the DT cord-267475-6f4h3cck 240 5 first first JJ cord-267475-6f4h3cck 240 6 and and CC cord-267475-6f4h3cck 240 7 second second JJ cord-267475-6f4h3cck 240 8 start start NN cord-267475-6f4h3cck 240 9 codons codon NNS cord-267475-6f4h3cck 240 10 are be VBP cord-267475-6f4h3cck 240 11 in in IN cord-267475-6f4h3cck 240 12 different different JJ cord-267475-6f4h3cck 240 13 reading reading NN cord-267475-6f4h3cck 240 14 frames frame NNS cord-267475-6f4h3cck 240 15 , , , cord-267475-6f4h3cck 240 16 indicated indicate VBN cord-267475-6f4h3cck 240 17 by by IN cord-267475-6f4h3cck 240 18 italicizing italicize VBG cord-267475-6f4h3cck 240 19 the the DT cord-267475-6f4h3cck 240 20 second second JJ cord-267475-6f4h3cck 240 21 product product NN cord-267475-6f4h3cck 240 22 , , , cord-267475-6f4h3cck 240 23 the the DT cord-267475-6f4h3cck 240 24 extent extent NN cord-267475-6f4h3cck 240 25 of of IN cord-267475-6f4h3cck 240 26 overlap overlap NN cord-267475-6f4h3cck 240 27 between between IN cord-267475-6f4h3cck 240 28 the the DT cord-267475-6f4h3cck 240 29 two two CD cord-267475-6f4h3cck 240 30 ORFs orfs NN cord-267475-6f4h3cck 240 31 ranges range VBZ cord-267475-6f4h3cck 240 32 from from IN cord-267475-6f4h3cck 240 33 a a DT cord-267475-6f4h3cck 240 34 few few JJ cord-267475-6f4h3cck 240 35 codons codon NNS cord-267475-6f4h3cck 240 36 ( ( -LRB- cord-267475-6f4h3cck 240 37 peanut peanut NN cord-267475-6f4h3cck 240 38 clump clump NN cord-267475-6f4h3cck 240 39 virus virus NN cord-267475-6f4h3cck 240 40 , , , cord-267475-6f4h3cck 240 41 southern southern JJ cord-267475-6f4h3cck 240 42 bean bean NN cord-267475-6f4h3cck 240 43 mosaic mosaic NNP cord-267475-6f4h3cck 240 44 virus virus NN cord-267475-6f4h3cck 240 45 ) ) -RRB- cord-267475-6f4h3cck 240 46 to to IN cord-267475-6f4h3cck 240 47 626 626 CD cord-267475-6f4h3cck 240 48 codons codon NNS cord-267475-6f4h3cck 240 49 ( ( -LRB- cord-267475-6f4h3cck 240 50 turnip turnip NNP cord-267475-6f4h3cck 240 51 yellow yellow NNP cord-267475-6f4h3cck 240 52 mosaic mosaic NNP cord-267475-6f4h3cck 240 53 virus virus NN cord-267475-6f4h3cck 240 54 ) ) -RRB- cord-267475-6f4h3cck 240 55 . . . cord-267475-6f4h3cck 241 1 d d NNP cord-267475-6f4h3cck 241 2 Access Access NNP cord-267475-6f4h3cck 241 3 to to IN cord-267475-6f4h3cck 241 4 the the DT cord-267475-6f4h3cck 241 5 downstream downstream JJ cord-267475-6f4h3cck 241 6 initiation initiation NN cord-267475-6f4h3cck 241 7 site site NN cord-267475-6f4h3cck 241 8 via via IN cord-267475-6f4h3cck 241 9 leaky leaky JJ cord-267475-6f4h3cck 241 10 scanning scanning NN cord-267475-6f4h3cck 241 11 is be VBZ cord-267475-6f4h3cck 241 12 augmented augment VBN cord-267475-6f4h3cck 241 13 by by IN cord-267475-6f4h3cck 241 14 a a DT cord-267475-6f4h3cck 241 15 reinitiation reinitiation NN cord-267475-6f4h3cck 241 16 shunt shunt NN cord-267475-6f4h3cck 241 17 , , , cord-267475-6f4h3cck 241 18 as as IN cord-267475-6f4h3cck 241 19 explained explain VBN cord-267475-6f4h3cck 241 20 in in IN cord-267475-6f4h3cck 241 21 the the DT cord-267475-6f4h3cck 241 22 text text NN cord-267475-6f4h3cck 241 23 ( ( -LRB- cord-267475-6f4h3cck 241 24 Section section NN cord-267475-6f4h3cck 241 25 4.3 4.3 CD cord-267475-6f4h3cck 241 26 ) ) -RRB- cord-267475-6f4h3cck 241 27 and and CC cord-267475-6f4h3cck 241 28 diagrammed diagram VBN cord-267475-6f4h3cck 241 29 in in IN cord-267475-6f4h3cck 241 30 Fig Fig NNP cord-267475-6f4h3cck 241 31 . . . cord-267475-6f4h3cck 242 1 1 1 CD cord-267475-6f4h3cck 242 2 for for IN cord-267475-6f4h3cck 243 1 C C NNP cord-267475-6f4h3cck 243 2 / / SYM cord-267475-6f4h3cck 243 3 EBPb EBPb NNP cord-267475-6f4h3cck 243 4 mRNA mRNA NNP cord-267475-6f4h3cck 243 5 . . . cord-267475-6f4h3cck 244 1 e e LS cord-267475-6f4h3cck 244 2 Mutations mutation NNS cord-267475-6f4h3cck 244 3 that that WDT cord-267475-6f4h3cck 244 4 eliminate eliminate VBP cord-267475-6f4h3cck 244 5 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 244 6 usually usually RB cord-267475-6f4h3cck 244 7 increase increase VB cord-267475-6f4h3cck 244 8 production production NN cord-267475-6f4h3cck 244 9 of of IN cord-267475-6f4h3cck 244 10 the the DT cord-267475-6f4h3cck 244 11 second second JJ cord-267475-6f4h3cck 244 12 , , , cord-267475-6f4h3cck 244 13 downstream downstream JJ cord-267475-6f4h3cck 244 14 protein protein NN cord-267475-6f4h3cck 244 15 . . . cord-267475-6f4h3cck 245 1 In in IN cord-267475-6f4h3cck 245 2 rare rare JJ cord-267475-6f4h3cck 245 3 cases case NNS cord-267475-6f4h3cck 245 4 where where WRB cord-267475-6f4h3cck 245 5 the the DT cord-267475-6f4h3cck 245 6 expected expect VBN cord-267475-6f4h3cck 245 7 increase increase NN cord-267475-6f4h3cck 245 8 was be VBD cord-267475-6f4h3cck 245 9 not not RB cord-267475-6f4h3cck 245 10 seen see VBN cord-267475-6f4h3cck 245 11 ( ( -LRB- cord-267475-6f4h3cck 245 12 e.g. e.g. RB cord-267475-6f4h3cck 245 13 von von NNP cord-267475-6f4h3cck 245 14 Hippel Hippel NNP cord-267475-6f4h3cck 245 15 - - HYPH cord-267475-6f4h3cck 245 16 Lindau Lindau NNP cord-267475-6f4h3cck 245 17 , , , cord-267475-6f4h3cck 245 18 turnip turnip NN cord-267475-6f4h3cck 245 19 yellow yellow JJ cord-267475-6f4h3cck 245 20 mosaic mosaic NNP cord-267475-6f4h3cck 245 21 virus virus NN cord-267475-6f4h3cck 245 22 ) ) -RRB- cord-267475-6f4h3cck 245 23 , , , cord-267475-6f4h3cck 245 24 it -PRON- PRP cord-267475-6f4h3cck 245 25 might may MD cord-267475-6f4h3cck 245 26 be be VB cord-267475-6f4h3cck 245 27 because because IN cord-267475-6f4h3cck 245 28 translation translation NN cord-267475-6f4h3cck 245 29 of of IN cord-267475-6f4h3cck 245 30 the the DT cord-267475-6f4h3cck 245 31 second second JJ cord-267475-6f4h3cck 245 32 protein protein NN cord-267475-6f4h3cck 245 33 was be VBD cord-267475-6f4h3cck 245 34 restricted restrict VBN cord-267475-6f4h3cck 245 35 at at IN cord-267475-6f4h3cck 245 36 the the DT cord-267475-6f4h3cck 245 37 level level NN cord-267475-6f4h3cck 245 38 of of IN cord-267475-6f4h3cck 245 39 elongation elongation NN cord-267475-6f4h3cck 245 40 . . . cord-267475-6f4h3cck 246 1 For for IN cord-267475-6f4h3cck 246 2 a a DT cord-267475-6f4h3cck 246 3 similar similar JJ cord-267475-6f4h3cck 246 4 reason reason NN cord-267475-6f4h3cck 246 5 , , , cord-267475-6f4h3cck 246 6 improving improve VBG cord-267475-6f4h3cck 246 7 the the DT cord-267475-6f4h3cck 246 8 context context NN cord-267475-6f4h3cck 246 9 around around IN cord-267475-6f4h3cck 246 10 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 246 11 occasionally occasionally RB cord-267475-6f4h3cck 246 12 fails fail VBZ cord-267475-6f4h3cck 246 13 to to TO cord-267475-6f4h3cck 246 14 elevate elevate VB cord-267475-6f4h3cck 246 15 production production NN cord-267475-6f4h3cck 246 16 of of IN cord-267475-6f4h3cck 246 17 the the DT cord-267475-6f4h3cck 246 18 protein protein NN cord-267475-6f4h3cck 246 19 there there RB cord-267475-6f4h3cck 246 20 initiated initiate VBD cord-267475-6f4h3cck 246 21 ( ( -LRB- cord-267475-6f4h3cck 246 22 Fajardo Fajardo NNP cord-267475-6f4h3cck 246 23 and and CC cord-267475-6f4h3cck 246 24 Shatkin Shatkin NNP cord-267475-6f4h3cck 246 25 , , , cord-267475-6f4h3cck 246 26 1990 1990 CD cord-267475-6f4h3cck 246 27 ) ) -RRB- cord-267475-6f4h3cck 246 28 . . . cord-267475-6f4h3cck 247 1 These these DT cord-267475-6f4h3cck 247 2 entries entry NNS cord-267475-6f4h3cck 247 3 nevertheless nevertheless RB cord-267475-6f4h3cck 247 4 satisfy satisfy VBP cord-267475-6f4h3cck 247 5 the the DT cord-267475-6f4h3cck 247 6 main main JJ cord-267475-6f4h3cck 247 7 prediction prediction NN cord-267475-6f4h3cck 247 8 of of IN cord-267475-6f4h3cck 247 9 the the DT cord-267475-6f4h3cck 247 10 leaky leaky JJ cord-267475-6f4h3cck 247 11 scanning scanning NN cord-267475-6f4h3cck 247 12 mechanism mechanism NN cord-267475-6f4h3cck 247 13 , , , cord-267475-6f4h3cck 247 14 which which WDT cord-267475-6f4h3cck 247 15 is be VBZ cord-267475-6f4h3cck 247 16 that that IN cord-267475-6f4h3cck 247 17 improving improve VBG cord-267475-6f4h3cck 247 18 the the DT cord-267475-6f4h3cck 247 19 context context NN cord-267475-6f4h3cck 247 20 around around IN cord-267475-6f4h3cck 247 21 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 247 22 prevents prevent VBZ cord-267475-6f4h3cck 247 23 initiation initiation NN cord-267475-6f4h3cck 247 24 from from IN cord-267475-6f4h3cck 247 25 the the DT cord-267475-6f4h3cck 247 26 second second JJ cord-267475-6f4h3cck 247 27 , , , cord-267475-6f4h3cck 247 28 downstream downstream JJ cord-267475-6f4h3cck 247 29 site site NN cord-267475-6f4h3cck 247 30 ( ( -LRB- cord-267475-6f4h3cck 247 31 Fajardo Fajardo NNP cord-267475-6f4h3cck 247 32 and and CC cord-267475-6f4h3cck 247 33 Shatkin Shatkin NNP cord-267475-6f4h3cck 247 34 , , , cord-267475-6f4h3cck 247 35 1990 1990 CD cord-267475-6f4h3cck 247 36 ; ; : cord-267475-6f4h3cck 247 37 Iliopoulos Iliopoulos NNP cord-267475-6f4h3cck 247 38 et et NNP cord-267475-6f4h3cck 247 39 al al NNP cord-267475-6f4h3cck 247 40 . . NNP cord-267475-6f4h3cck 247 41 , , , cord-267475-6f4h3cck 247 42 1998 1998 CD cord-267475-6f4h3cck 247 43 ) ) -RRB- cord-267475-6f4h3cck 247 44 . . . cord-267475-6f4h3cck 248 1 f f NNP cord-267475-6f4h3cck 249 1 Whereas whereas IN cord-267475-6f4h3cck 249 2 feline feline JJ cord-267475-6f4h3cck 249 3 leukemia leukemia NN cord-267475-6f4h3cck 249 4 virus virus NN cord-267475-6f4h3cck 249 5 produces produce VBZ cord-267475-6f4h3cck 249 6 an an DT cord-267475-6f4h3cck 249 7 N n CD cord-267475-6f4h3cck 249 8 - - HYPH cord-267475-6f4h3cck 249 9 terminally terminally RB cord-267475-6f4h3cck 249 10 - - HYPH cord-267475-6f4h3cck 249 11 extended extended JJ cord-267475-6f4h3cck 249 12 , , , cord-267475-6f4h3cck 249 13 glycosylated glycosylated JJ cord-267475-6f4h3cck 249 14 form form NN cord-267475-6f4h3cck 249 15 of of IN cord-267475-6f4h3cck 249 16 Gag gag NN cord-267475-6f4h3cck 249 17 ( ( -LRB- cord-267475-6f4h3cck 249 18 gp80 gp80 NN cord-267475-6f4h3cck 249 19 gag gag NN cord-267475-6f4h3cck 249 20 ) ) -RRB- cord-267475-6f4h3cck 249 21 from from IN cord-267475-6f4h3cck 249 22 the the DT cord-267475-6f4h3cck 249 23 indicated indicate VBN cord-267475-6f4h3cck 249 24 weak weak JJ cord-267475-6f4h3cck 249 25 AUG AUG NNP cord-267475-6f4h3cck 249 26 codon codon NN cord-267475-6f4h3cck 249 27 , , , cord-267475-6f4h3cck 250 1 the the DT cord-267475-6f4h3cck 250 2 corresponding corresponding JJ cord-267475-6f4h3cck 250 3 upstream upstream JJ cord-267475-6f4h3cck 250 4 start start NN cord-267475-6f4h3cck 250 5 site site NN cord-267475-6f4h3cck 250 6 in in IN cord-267475-6f4h3cck 250 7 murine murine JJ cord-267475-6f4h3cck 250 8 leukemia leukemia NN cord-267475-6f4h3cck 250 9 virus virus NN cord-267475-6f4h3cck 250 10 is be VBZ cord-267475-6f4h3cck 250 11 ACCCUGG ACCCUGG NNP cord-267475-6f4h3cck 250 12 ( ( -LRB- cord-267475-6f4h3cck 251 1 Portis Portis NNP cord-267475-6f4h3cck 251 2 et et NNP cord-267475-6f4h3cck 251 3 al al NNP cord-267475-6f4h3cck 251 4 . . NNP cord-267475-6f4h3cck 251 5 , , , cord-267475-6f4h3cck 251 6 1994 1994 CD cord-267475-6f4h3cck 251 7 ) ) -RRB- cord-267475-6f4h3cck 251 8 . . . cord-267475-6f4h3cck 252 1 When when WRB cord-267475-6f4h3cck 252 2 that that DT cord-267475-6f4h3cck 252 3 site site NN cord-267475-6f4h3cck 252 4 was be VBD cord-267475-6f4h3cck 252 5 experimentally experimentally RB cord-267475-6f4h3cck 252 6 ablated ablate VBN cord-267475-6f4h3cck 252 7 , , , cord-267475-6f4h3cck 252 8 however however RB cord-267475-6f4h3cck 252 9 , , , cord-267475-6f4h3cck 252 10 revertants revertants NNP cord-267475-6f4h3cck 252 11 expressed express VBD cord-267475-6f4h3cck 252 12 the the DT cord-267475-6f4h3cck 252 13 extended extended JJ cord-267475-6f4h3cck 252 14 protein protein NN cord-267475-6f4h3cck 252 15 from from IN cord-267475-6f4h3cck 252 16 a a DT cord-267475-6f4h3cck 252 17 weak weak JJ cord-267475-6f4h3cck 252 18 upstream upstream JJ cord-267475-6f4h3cck 252 19 AUG AUG NNP cord-267475-6f4h3cck 252 20 codon codon NN cord-267475-6f4h3cck 252 21 ( ( -LRB- cord-267475-6f4h3cck 252 22 UUUaugG uuuaugg JJ cord-267475-6f4h3cck 252 23 ) ) -RRB- cord-267475-6f4h3cck 252 24 created create VBN cord-267475-6f4h3cck 252 25 by by IN cord-267475-6f4h3cck 252 26 a a DT cord-267475-6f4h3cck 252 27 point point NN cord-267475-6f4h3cck 252 28 mutation mutation NN cord-267475-6f4h3cck 252 29 . . . cord-267475-6f4h3cck 253 1 Those those DT cord-267475-6f4h3cck 253 2 revertants revertant NNS cord-267475-6f4h3cck 253 3 were be VBD cord-267475-6f4h3cck 253 4 selected select VBN cord-267475-6f4h3cck 253 5 because because IN cord-267475-6f4h3cck 253 6 the the DT cord-267475-6f4h3cck 253 7 extra extra JJ cord-267475-6f4h3cck 253 8 glycosylated glycosylated JJ cord-267475-6f4h3cck 253 9 form form NN cord-267475-6f4h3cck 253 10 of of IN cord-267475-6f4h3cck 253 11 Gag Gag NNP cord-267475-6f4h3cck 253 12 contributes contribute VBZ cord-267475-6f4h3cck 253 13 to to IN cord-267475-6f4h3cck 253 14 viral viral JJ cord-267475-6f4h3cck 253 15 spread spread NN cord-267475-6f4h3cck 253 16 ( ( -LRB- cord-267475-6f4h3cck 253 17 Portis Portis NNP cord-267475-6f4h3cck 253 18 et et NNP cord-267475-6f4h3cck 253 19 al al NNP cord-267475-6f4h3cck 253 20 . . NNP cord-267475-6f4h3cck 253 21 , , , cord-267475-6f4h3cck 253 22 1996 1996 CD cord-267475-6f4h3cck 253 23 ) ) -RRB- cord-267475-6f4h3cck 253 24 . . . cord-267475-6f4h3cck 254 1 g g NNP cord-267475-6f4h3cck 255 1 In in IN cord-267475-6f4h3cck 255 2 the the DT cord-267475-6f4h3cck 255 3 mRNAs mRNAs NNPS cord-267475-6f4h3cck 255 4 from from IN cord-267475-6f4h3cck 255 5 baboon baboon NNP cord-267475-6f4h3cck 255 6 reovirus reovirus NNP cord-267475-6f4h3cck 255 7 , , , cord-267475-6f4h3cck 255 8 influenza influenza NN cord-267475-6f4h3cck 255 9 A a DT cord-267475-6f4h3cck 255 10 virus virus NN cord-267475-6f4h3cck 255 11 , , , cord-267475-6f4h3cck 255 12 and and CC cord-267475-6f4h3cck 255 13 southern southern JJ cord-267475-6f4h3cck 255 14 bean bean NN cord-267475-6f4h3cck 255 15 mosaic mosaic NNP cord-267475-6f4h3cck 255 16 virus virus NN cord-267475-6f4h3cck 255 17 , , , cord-267475-6f4h3cck 255 18 the the DT cord-267475-6f4h3cck 255 19 indicated indicate VBN cord-267475-6f4h3cck 255 20 proteins protein NNS cord-267475-6f4h3cck 255 21 derive derive VBP cord-267475-6f4h3cck 255 22 from from IN cord-267475-6f4h3cck 255 23 the the DT cord-267475-6f4h3cck 255 24 first first JJ cord-267475-6f4h3cck 255 25 ( ( -LRB- cord-267475-6f4h3cck 255 26 weak weak JJ cord-267475-6f4h3cck 255 27 ) ) -RRB- cord-267475-6f4h3cck 255 28 and and CC cord-267475-6f4h3cck 255 29 fourth fourth JJ cord-267475-6f4h3cck 255 30 AUG AUG NNP cord-267475-6f4h3cck 255 31 codons codon NNS cord-267475-6f4h3cck 255 32 . . . cord-267475-6f4h3cck 256 1 AUG#2 AUG#2 NNP cord-267475-6f4h3cck 256 2 and and CC cord-267475-6f4h3cck 256 3 AUG#3 AUG#3 NNPS cord-267475-6f4h3cck 256 4 initiate initiate VB cord-267475-6f4h3cck 256 5 small small JJ cord-267475-6f4h3cck 256 6 ORFs orf NNS cord-267475-6f4h3cck 256 7 that that WDT cord-267475-6f4h3cck 256 8 terminate terminate VBP cord-267475-6f4h3cck 256 9 before before IN cord-267475-6f4h3cck 256 10 AUG#4 aug#4 CD cord-267475-6f4h3cck 256 11 . . . cord-267475-6f4h3cck 257 1 Thus thus RB cord-267475-6f4h3cck 257 2 , , , cord-267475-6f4h3cck 257 3 a a DT cord-267475-6f4h3cck 257 4 combination combination NN cord-267475-6f4h3cck 257 5 of of IN cord-267475-6f4h3cck 257 6 leaky leaky JJ cord-267475-6f4h3cck 257 7 scanning scanning NN cord-267475-6f4h3cck 257 8 and and CC cord-267475-6f4h3cck 257 9 reinitiation reinitiation NN cord-267475-6f4h3cck 257 10 probably probably RB cord-267475-6f4h3cck 257 11 mediates mediate VBZ cord-267475-6f4h3cck 257 12 access access NN cord-267475-6f4h3cck 257 13 to to IN cord-267475-6f4h3cck 257 14 the the DT cord-267475-6f4h3cck 257 15 downstream downstream JJ cord-267475-6f4h3cck 257 16 start start NN cord-267475-6f4h3cck 257 17 site site NN cord-267475-6f4h3cck 257 18 . . . cord-267475-6f4h3cck 258 1 Nichol Nichol NNP cord-267475-6f4h3cck 258 2 , , , cord-267475-6f4h3cck 258 3 1993 1993 CD cord-267475-6f4h3cck 258 4 ; ; : cord-267475-6f4h3cck 258 5 Werten Werten NNP cord-267475-6f4h3cck 258 6 et et NNP cord-267475-6f4h3cck 258 7 al al NNP cord-267475-6f4h3cck 258 8 . . NNP cord-267475-6f4h3cck 258 9 , , , cord-267475-6f4h3cck 258 10 1999 1999 CD cord-267475-6f4h3cck 258 11 ) ) -RRB- cord-267475-6f4h3cck 258 12 or or CC cord-267475-6f4h3cck 259 1 when when WRB cord-267475-6f4h3cck 259 2 the the DT cord-267475-6f4h3cck 259 3 facilitating facilitate VBG cord-267475-6f4h3cck 259 4 effect effect NN cord-267475-6f4h3cck 259 5 of of IN cord-267475-6f4h3cck 259 6 G g NN cord-267475-6f4h3cck 259 7 in in IN cord-267475-6f4h3cck 259 8 position position NN cord-267475-6f4h3cck 259 9 þ þ NNP cord-267475-6f4h3cck 259 10 4 4 CD cord-267475-6f4h3cck 259 11 is be VBZ cord-267475-6f4h3cck 259 12 canceled cancel VBN cord-267475-6f4h3cck 259 13 by by IN cord-267475-6f4h3cck 259 14 U U NNP cord-267475-6f4h3cck 259 15 in in IN cord-267475-6f4h3cck 259 16 position position NN cord-267475-6f4h3cck 259 17 þ þ NNP cord-267475-6f4h3cck 259 18 5 5 CD cord-267475-6f4h3cck 259 19 ( ( -LRB- cord-267475-6f4h3cck 259 20 Kozak Kozak NNP cord-267475-6f4h3cck 259 21 , , , cord-267475-6f4h3cck 259 22 1997 1997 CD cord-267475-6f4h3cck 259 23 ; ; . cord-267475-6f4h3cck 260 1 Sloan Sloan NNP cord-267475-6f4h3cck 260 2 et et NNP cord-267475-6f4h3cck 260 3 al al NNP cord-267475-6f4h3cck 260 4 . . . cord-267475-6f4h3cck 261 1 , , , cord-267475-6f4h3cck 261 2 1999 1999 CD cord-267475-6f4h3cck 261 3 ; ; : cord-267475-6f4h3cck 261 4 Stallmeyer Stallmeyer NNP cord-267475-6f4h3cck 261 5 et et NNP cord-267475-6f4h3cck 261 6 al al NNP cord-267475-6f4h3cck 261 7 . . NNP cord-267475-6f4h3cck 261 8 , , , cord-267475-6f4h3cck 261 9 1999 1999 CD cord-267475-6f4h3cck 261 10 ) ) -RRB- cord-267475-6f4h3cck 261 11 . . . cord-267475-6f4h3cck 262 1 Other other JJ cord-267475-6f4h3cck 262 2 occasional occasional JJ cord-267475-6f4h3cck 262 3 claims claim NNS cord-267475-6f4h3cck 262 4 of of IN cord-267475-6f4h3cck 262 5 leaky leaky JJ cord-267475-6f4h3cck 262 6 scanning scanning NN cord-267475-6f4h3cck 262 7 despite despite IN cord-267475-6f4h3cck 262 8 a a DT cord-267475-6f4h3cck 262 9 strong strong JJ cord-267475-6f4h3cck 262 10 context context NN cord-267475-6f4h3cck 262 11 at at IN cord-267475-6f4h3cck 262 12 the the DT cord-267475-6f4h3cck 262 13 first first JJ cord-267475-6f4h3cck 262 14 AUG AUG NNP cord-267475-6f4h3cck 262 15 codon codon NN cord-267475-6f4h3cck 262 16 were be VBD cord-267475-6f4h3cck 262 17 simply simply RB cord-267475-6f4h3cck 262 18 mistaken mistaken JJ cord-267475-6f4h3cck 263 1 ( ( -LRB- cord-267475-6f4h3cck 263 2 Scherer Scherer NNP cord-267475-6f4h3cck 263 3 et et NNP cord-267475-6f4h3cck 263 4 al al NNP cord-267475-6f4h3cck 263 5 . . NNP cord-267475-6f4h3cck 263 6 , , , cord-267475-6f4h3cck 263 7 1995 1995 CD cord-267475-6f4h3cck 263 8 ) ) -RRB- cord-267475-6f4h3cck 263 9 ; ; : cord-267475-6f4h3cck 263 10 the the DT cord-267475-6f4h3cck 263 11 shorter short JJR cord-267475-6f4h3cck 263 12 protein protein NN cord-267475-6f4h3cck 263 13 turned turn VBD cord-267475-6f4h3cck 263 14 out out RP cord-267475-6f4h3cck 263 15 to to TO cord-267475-6f4h3cck 263 16 be be VB cord-267475-6f4h3cck 263 17 translated translate VBN cord-267475-6f4h3cck 263 18 from from IN cord-267475-6f4h3cck 263 19 a a DT cord-267475-6f4h3cck 263 20 second second JJ cord-267475-6f4h3cck 263 21 form form NN cord-267475-6f4h3cck 263 22 of of IN cord-267475-6f4h3cck 263 23 mRNA mrna NN cord-267475-6f4h3cck 264 1 ( ( -LRB- cord-267475-6f4h3cck 264 2 Kogo Kogo NNP cord-267475-6f4h3cck 264 3 and and CC cord-267475-6f4h3cck 264 4 Fujimoto Fujimoto NNP cord-267475-6f4h3cck 264 5 , , , cord-267475-6f4h3cck 264 6 2000 2000 CD cord-267475-6f4h3cck 264 7 ) ) -RRB- cord-267475-6f4h3cck 264 8 . . . cord-267475-6f4h3cck 265 1 At at IN cord-267475-6f4h3cck 265 2 the the DT cord-267475-6f4h3cck 265 3 opposite opposite JJ cord-267475-6f4h3cck 265 4 extreme extreme NN cord-267475-6f4h3cck 265 5 , , , cord-267475-6f4h3cck 265 6 there there EX cord-267475-6f4h3cck 265 7 are be VBP cord-267475-6f4h3cck 265 8 rare rare JJ cord-267475-6f4h3cck 265 9 mammalian mammalian NN cord-267475-6f4h3cck 265 10 mRNAs mRNAs NNPS cord-267475-6f4h3cck 265 11 in in IN cord-267475-6f4h3cck 265 12 which which WDT cord-267475-6f4h3cck 265 13 , , , cord-267475-6f4h3cck 265 14 despite despite IN cord-267475-6f4h3cck 265 15 a a DT cord-267475-6f4h3cck 265 16 very very RB cord-267475-6f4h3cck 265 17 unfavorable unfavorable JJ cord-267475-6f4h3cck 265 18 context context NN cord-267475-6f4h3cck 265 19 flanking flank VBG cord-267475-6f4h3cck 265 20 the the DT cord-267475-6f4h3cck 265 21 first first JJ cord-267475-6f4h3cck 265 22 AUG AUG NNP cord-267475-6f4h3cck 265 23 codon codon NN cord-267475-6f4h3cck 265 24 , , , cord-267475-6f4h3cck 265 25 translation translation NN cord-267475-6f4h3cck 265 26 appears appear VBZ cord-267475-6f4h3cck 265 27 to to TO cord-267475-6f4h3cck 265 28 initiate initiate VB cord-267475-6f4h3cck 265 29 exclusively exclusively RB cord-267475-6f4h3cck 265 30 at at IN cord-267475-6f4h3cck 265 31 that that DT cord-267475-6f4h3cck 265 32 site site NN cord-267475-6f4h3cck 265 33 ( ( -LRB- cord-267475-6f4h3cck 265 34 Arai Arai NNP cord-267475-6f4h3cck 265 35 et et NNP cord-267475-6f4h3cck 265 36 al al NNP cord-267475-6f4h3cck 265 37 . . NNP cord-267475-6f4h3cck 265 38 , , , cord-267475-6f4h3cck 265 39 1991 1991 CD cord-267475-6f4h3cck 265 40 ; ; : cord-267475-6f4h3cck 266 1 Hickey Hickey NNP cord-267475-6f4h3cck 266 2 and and CC cord-267475-6f4h3cck 266 3 Roth Roth NNP cord-267475-6f4h3cck 266 4 , , , cord-267475-6f4h3cck 266 5 1993 1993 CD cord-267475-6f4h3cck 266 6 ; ; : cord-267475-6f4h3cck 266 7 Leslie Leslie NNP cord-267475-6f4h3cck 266 8 et et NNP cord-267475-6f4h3cck 266 9 al al NNP cord-267475-6f4h3cck 266 10 . . NNP cord-267475-6f4h3cck 266 11 , , , cord-267475-6f4h3cck 266 12 1992 1992 CD cord-267475-6f4h3cck 266 13 ; ; : cord-267475-6f4h3cck 266 14 McNeil McNeil NNP cord-267475-6f4h3cck 266 15 et et NNP cord-267475-6f4h3cck 266 16 al al NNP cord-267475-6f4h3cck 266 17 . . NNP cord-267475-6f4h3cck 266 18 , , , cord-267475-6f4h3cck 266 19 1992 1992 CD cord-267475-6f4h3cck 266 20 ; ; : cord-267475-6f4h3cck 266 21 Plowman Plowman NNP cord-267475-6f4h3cck 266 22 et et FW cord-267475-6f4h3cck 266 23 al al NNP cord-267475-6f4h3cck 266 24 . . NNP cord-267475-6f4h3cck 266 25 , , , cord-267475-6f4h3cck 266 26 1990 1990 CD cord-267475-6f4h3cck 266 27 ; ; : cord-267475-6f4h3cck 266 28 Wu Wu NNP cord-267475-6f4h3cck 266 29 et et NNP cord-267475-6f4h3cck 266 30 al al NNP cord-267475-6f4h3cck 266 31 . . NNP cord-267475-6f4h3cck 266 32 , , , cord-267475-6f4h3cck 266 33 1993a 1993a CD cord-267475-6f4h3cck 266 34 ) ) -RRB- cord-267475-6f4h3cck 266 35 . . . cord-267475-6f4h3cck 267 1 Leaky leaky JJ cord-267475-6f4h3cck 267 2 scanning scanning NN cord-267475-6f4h3cck 267 3 might may MD cord-267475-6f4h3cck 267 4 be be VB cord-267475-6f4h3cck 267 5 suppressed suppress VBN cord-267475-6f4h3cck 267 6 in in IN cord-267475-6f4h3cck 267 7 these these DT cord-267475-6f4h3cck 267 8 and and CC cord-267475-6f4h3cck 267 9 a a DT cord-267475-6f4h3cck 267 10 few few JJ cord-267475-6f4h3cck 267 11 other other JJ cord-267475-6f4h3cck 267 12 cases case NNS cord-267475-6f4h3cck 267 13 because because IN cord-267475-6f4h3cck 267 14 of of IN cord-267475-6f4h3cck 267 15 downstream downstream JJ cord-267475-6f4h3cck 267 16 secondary secondary JJ cord-267475-6f4h3cck 267 17 structure structure NN cord-267475-6f4h3cck 267 18 , , , cord-267475-6f4h3cck 267 19 or or CC cord-267475-6f4h3cck 267 20 because because IN cord-267475-6f4h3cck 267 21 the the DT cord-267475-6f4h3cck 267 22 wider wide JJR cord-267475-6f4h3cck 267 23 context context NN cord-267475-6f4h3cck 267 24 ( ( -LRB- cord-267475-6f4h3cck 267 25 C C NNP cord-267475-6f4h3cck 267 26 in in IN cord-267475-6f4h3cck 267 27 positions position NNS cord-267475-6f4h3cck 267 28 21 21 CD cord-267475-6f4h3cck 267 29 , , , cord-267475-6f4h3cck 267 30 22 22 CD cord-267475-6f4h3cck 267 31 , , , cord-267475-6f4h3cck 267 32 24 24 CD cord-267475-6f4h3cck 267 33 , , , cord-267475-6f4h3cck 267 34 2 2 CD cord-267475-6f4h3cck 267 35 5 5 CD cord-267475-6f4h3cck 267 36 ; ; : cord-267475-6f4h3cck 267 37 G g NN cord-267475-6f4h3cck 267 38 in in IN cord-267475-6f4h3cck 267 39 position position NN cord-267475-6f4h3cck 267 40 2 2 CD cord-267475-6f4h3cck 267 41 6 6 CD cord-267475-6f4h3cck 267 42 ) ) -RRB- cord-267475-6f4h3cck 267 43 compensates compensate VBZ cord-267475-6f4h3cck 267 44 to to IN cord-267475-6f4h3cck 267 45 some some DT cord-267475-6f4h3cck 267 46 extent extent NN cord-267475-6f4h3cck 267 47 for for IN cord-267475-6f4h3cck 267 48 the the DT cord-267475-6f4h3cck 267 49 absence absence NN cord-267475-6f4h3cck 267 50 of of IN cord-267475-6f4h3cck 267 51 R R NNP cord-267475-6f4h3cck 267 52 23 23 CD cord-267475-6f4h3cck 267 53 and and CC cord-267475-6f4h3cck 267 54 G G NNP cord-267475-6f4h3cck 267 55 þ4 þ4 NNP cord-267475-6f4h3cck 267 56 , , , cord-267475-6f4h3cck 267 57 or or CC cord-267475-6f4h3cck 267 58 for for IN cord-267475-6f4h3cck 267 59 other other JJ cord-267475-6f4h3cck 267 60 unknown unknown JJ cord-267475-6f4h3cck 267 61 reasons reason NNS cord-267475-6f4h3cck 267 62 . . . cord-267475-6f4h3cck 268 1 The the DT cord-267475-6f4h3cck 268 2 same same JJ cord-267475-6f4h3cck 268 3 principle principle NN cord-267475-6f4h3cck 268 4 that that WDT cord-267475-6f4h3cck 268 5 allows allow VBZ cord-267475-6f4h3cck 268 6 initiation initiation NN cord-267475-6f4h3cck 268 7 from from IN cord-267475-6f4h3cck 268 8 the the DT cord-267475-6f4h3cck 268 9 first first JJ cord-267475-6f4h3cck 268 10 and and CC cord-267475-6f4h3cck 268 11 second second JJ cord-267475-6f4h3cck 268 12 AUG AUG NNP cord-267475-6f4h3cck 268 13 codons codon NNS cord-267475-6f4h3cck 268 14 when when WRB cord-267475-6f4h3cck 268 15 the the DT cord-267475-6f4h3cck 268 16 first first JJ cord-267475-6f4h3cck 268 17 AUG AUG NNP cord-267475-6f4h3cck 268 18 is be VBZ cord-267475-6f4h3cck 268 19 in in IN cord-267475-6f4h3cck 268 20 a a DT cord-267475-6f4h3cck 268 21 suboptimal suboptimal JJ cord-267475-6f4h3cck 268 22 context context NN cord-267475-6f4h3cck 268 23 ( ( -LRB- cord-267475-6f4h3cck 268 24 Table table NN cord-267475-6f4h3cck 268 25 3 3 CD cord-267475-6f4h3cck 268 26 ) ) -RRB- cord-267475-6f4h3cck 268 27 applies apply VBZ cord-267475-6f4h3cck 268 28 in in IN cord-267475-6f4h3cck 268 29 cases case NNS cord-267475-6f4h3cck 268 30 where where WRB cord-267475-6f4h3cck 268 31 translation translation NN cord-267475-6f4h3cck 268 32 initiates initiate VBZ cord-267475-6f4h3cck 268 33 at at IN cord-267475-6f4h3cck 268 34 an an DT cord-267475-6f4h3cck 268 35 upstream upstream JJ cord-267475-6f4h3cck 268 36 non non JJ cord-267475-6f4h3cck 268 37 - - JJ cord-267475-6f4h3cck 268 38 AUG AUG NNP cord-267475-6f4h3cck 268 39 codon codon NN cord-267475-6f4h3cck 268 40 in in IN cord-267475-6f4h3cck 268 41 addition addition NN cord-267475-6f4h3cck 268 42 to to IN cord-267475-6f4h3cck 268 43 the the DT cord-267475-6f4h3cck 268 44 first first JJ cord-267475-6f4h3cck 268 45 AUG AUG NNP cord-267475-6f4h3cck 268 46 ( ( -LRB- cord-267475-6f4h3cck 268 47 Acland Acland NNP cord-267475-6f4h3cck 268 48 et et NNP cord-267475-6f4h3cck 268 49 al al NNP cord-267475-6f4h3cck 268 50 . . NNP cord-267475-6f4h3cck 268 51 , , , cord-267475-6f4h3cck 268 52 1990 1990 CD cord-267475-6f4h3cck 268 53 ; ; : cord-267475-6f4h3cck 268 54 Arnaud Arnaud NNP cord-267475-6f4h3cck 268 55 et et NNP cord-267475-6f4h3cck 268 56 al al NNP cord-267475-6f4h3cck 268 57 . . NNP cord-267475-6f4h3cck 268 58 , , , cord-267475-6f4h3cck 268 59 1999 1999 CD cord-267475-6f4h3cck 268 60 ; ; : cord-267475-6f4h3cck 268 61 Carroll Carroll NNP cord-267475-6f4h3cck 268 62 and and CC cord-267475-6f4h3cck 268 63 Derse Derse NNP cord-267475-6f4h3cck 268 64 , , , cord-267475-6f4h3cck 268 65 1993 1993 CD cord-267475-6f4h3cck 268 66 ; ; : cord-267475-6f4h3cck 268 67 Fajardo Fajardo NNP cord-267475-6f4h3cck 268 68 et et NNP cord-267475-6f4h3cck 268 69 al al NNP cord-267475-6f4h3cck 268 70 . . NNP cord-267475-6f4h3cck 268 71 , , , cord-267475-6f4h3cck 268 72 1993 1993 CD cord-267475-6f4h3cck 268 73 ; ; : cord-267475-6f4h3cck 268 74 Florkiewicz Florkiewicz NNP cord-267475-6f4h3cck 268 75 and and CC cord-267475-6f4h3cck 268 76 Sommer Sommer NNP cord-267475-6f4h3cck 268 77 , , , cord-267475-6f4h3cck 268 78 1989 1989 CD cord-267475-6f4h3cck 268 79 ; ; : cord-267475-6f4h3cck 268 80 Fütterer Fütterer NNP cord-267475-6f4h3cck 268 81 et et NNP cord-267475-6f4h3cck 268 82 al al NNP cord-267475-6f4h3cck 268 83 . . NNP cord-267475-6f4h3cck 268 84 , , , cord-267475-6f4h3cck 268 85 1996 1996 CD cord-267475-6f4h3cck 268 86 ; ; : cord-267475-6f4h3cck 268 87 Fuxe Fuxe NNP cord-267475-6f4h3cck 268 88 et et NNP cord-267475-6f4h3cck 268 89 al al NNP cord-267475-6f4h3cck 268 90 . . NNP cord-267475-6f4h3cck 268 91 , , , cord-267475-6f4h3cck 268 92 2000 2000 CD cord-267475-6f4h3cck 268 93 ; ; : cord-267475-6f4h3cck 268 94 Lock Lock NNP cord-267475-6f4h3cck 268 95 et et FW cord-267475-6f4h3cck 268 96 al al NNP cord-267475-6f4h3cck 268 97 . . NNP cord-267475-6f4h3cck 268 98 , , , cord-267475-6f4h3cck 268 99 1991 1991 CD cord-267475-6f4h3cck 268 100 ; ; : cord-267475-6f4h3cck 268 101 Muralidhar Muralidhar NNP cord-267475-6f4h3cck 268 102 et et NNP cord-267475-6f4h3cck 268 103 al al NNP cord-267475-6f4h3cck 268 104 . . NNP cord-267475-6f4h3cck 268 105 , , , cord-267475-6f4h3cck 268 106 1994 1994 CD cord-267475-6f4h3cck 268 107 ; ; : cord-267475-6f4h3cck 268 108 Packham Packham NNP cord-267475-6f4h3cck 268 109 et et NNP cord-267475-6f4h3cck 268 110 al al NNP cord-267475-6f4h3cck 268 111 . . NNP cord-267475-6f4h3cck 268 112 , , , cord-267475-6f4h3cck 268 113 1997 1997 CD cord-267475-6f4h3cck 268 114 ; ; : cord-267475-6f4h3cck 268 115 Saris Saris NNP cord-267475-6f4h3cck 268 116 et et NNP cord-267475-6f4h3cck 268 117 al al NNP cord-267475-6f4h3cck 268 118 . . NNP cord-267475-6f4h3cck 268 119 , , , cord-267475-6f4h3cck 268 120 1991 1991 CD cord-267475-6f4h3cck 268 121 ; ; : cord-267475-6f4h3cck 268 122 Spotts Spotts NNP cord-267475-6f4h3cck 268 123 et et NNP cord-267475-6f4h3cck 268 124 al al NNP cord-267475-6f4h3cck 268 125 . . NNP cord-267475-6f4h3cck 268 126 , , , cord-267475-6f4h3cck 268 127 1997 1997 CD cord-267475-6f4h3cck 268 128 ) ) -RRB- cord-267475-6f4h3cck 268 129 . . . cord-267475-6f4h3cck 269 1 Recognition recognition NN cord-267475-6f4h3cck 269 2 of of IN cord-267475-6f4h3cck 269 3 an an DT cord-267475-6f4h3cck 269 4 upstream upstream JJ cord-267475-6f4h3cck 269 5 ACG ACG NNP cord-267475-6f4h3cck 269 6 , , , cord-267475-6f4h3cck 269 7 CUG CUG NNP cord-267475-6f4h3cck 269 8 or or CC cord-267475-6f4h3cck 269 9 GUG GUG NNP cord-267475-6f4h3cck 269 10 start start NN cord-267475-6f4h3cck 269 11 codon codon NN cord-267475-6f4h3cck 269 12 requires require VBZ cord-267475-6f4h3cck 269 13 a a DT cord-267475-6f4h3cck 269 14 strong strong JJ cord-267475-6f4h3cck 269 15 context context NN cord-267475-6f4h3cck 269 16 ( ( -LRB- cord-267475-6f4h3cck 269 17 Portis Portis NNP cord-267475-6f4h3cck 269 18 et et NNP cord-267475-6f4h3cck 269 19 al al NNP cord-267475-6f4h3cck 269 20 . . NNP cord-267475-6f4h3cck 269 21 , , , cord-267475-6f4h3cck 269 22 1994 1994 CD cord-267475-6f4h3cck 269 23 ) ) -RRB- cord-267475-6f4h3cck 269 24 , , , cord-267475-6f4h3cck 269 25 despite despite IN cord-267475-6f4h3cck 269 26 which which WDT cord-267475-6f4h3cck 269 27 scanning scanning NN cord-267475-6f4h3cck 269 28 is be VBZ cord-267475-6f4h3cck 269 29 usually usually RB cord-267475-6f4h3cck 269 30 leaky leaky JJ cord-267475-6f4h3cck 269 31 because because IN cord-267475-6f4h3cck 269 32 the the DT cord-267475-6f4h3cck 269 33 initiator initiator NN cord-267475-6f4h3cck 269 34 codon codon NN cord-267475-6f4h3cck 269 35 itself -PRON- PRP cord-267475-6f4h3cck 269 36 is be VBZ cord-267475-6f4h3cck 269 37 weak weak JJ cord-267475-6f4h3cck 269 38 . . . cord-267475-6f4h3cck 270 1 Production production NN cord-267475-6f4h3cck 270 2 of of IN cord-267475-6f4h3cck 270 3 long long JJ cord-267475-6f4h3cck 270 4 and and CC cord-267475-6f4h3cck 270 5 short short JJ cord-267475-6f4h3cck 270 6 protein protein NN cord-267475-6f4h3cck 270 7 isoforms isoform NNS cord-267475-6f4h3cck 270 8 via via IN cord-267475-6f4h3cck 270 9 leaky leaky JJ cord-267475-6f4h3cck 270 10 scanning scanning NN cord-267475-6f4h3cck 270 11 is be VBZ cord-267475-6f4h3cck 270 12 harder hard JJR cord-267475-6f4h3cck 270 13 to to TO cord-267475-6f4h3cck 270 14 regulate regulate VB cord-267475-6f4h3cck 270 15 -e.g -e.g NNS cord-267475-6f4h3cck 270 16 . . . cord-267475-6f4h3cck 271 1 to to TO cord-267475-6f4h3cck 271 2 achieve achieve VB cord-267475-6f4h3cck 271 3 tissue tissue NN cord-267475-6f4h3cck 271 4 specific specific JJ cord-267475-6f4h3cck 271 5 expression expression NN cord-267475-6f4h3cck 271 6 of of IN cord-267475-6f4h3cck 271 7 one one CD cord-267475-6f4h3cck 271 8 or or CC cord-267475-6f4h3cck 271 9 the the DT cord-267475-6f4h3cck 271 10 other other JJ cord-267475-6f4h3cck 271 11 form form NN cord-267475-6f4h3cck 271 12 -than -than : cord-267475-6f4h3cck 271 13 when when WRB cord-267475-6f4h3cck 271 14 a a DT cord-267475-6f4h3cck 271 15 unique unique JJ cord-267475-6f4h3cck 271 16 mRNA mrna NN cord-267475-6f4h3cck 271 17 encodes encode VBZ cord-267475-6f4h3cck 271 18 each each DT cord-267475-6f4h3cck 271 19 isoform isoform NN cord-267475-6f4h3cck 271 20 , , , cord-267475-6f4h3cck 271 21 as as IN cord-267475-6f4h3cck 271 22 in in IN cord-267475-6f4h3cck 271 23 Table Table NNP cord-267475-6f4h3cck 271 24 2 2 CD cord-267475-6f4h3cck 271 25 . . . cord-267475-6f4h3cck 272 1 There there EX cord-267475-6f4h3cck 272 2 are be VBP cord-267475-6f4h3cck 272 3 hints hint NNS cord-267475-6f4h3cck 272 4 , , , cord-267475-6f4h3cck 272 5 however however RB cord-267475-6f4h3cck 272 6 , , , cord-267475-6f4h3cck 272 7 that that IN cord-267475-6f4h3cck 272 8 dual dual JJ cord-267475-6f4h3cck 272 9 initiation initiation NN cord-267475-6f4h3cck 272 10 via via IN cord-267475-6f4h3cck 272 11 leaky leaky JJ cord-267475-6f4h3cck 272 12 scanning scanning NN cord-267475-6f4h3cck 272 13 might may MD cord-267475-6f4h3cck 272 14 be be VB cord-267475-6f4h3cck 272 15 regulable regulable JJ cord-267475-6f4h3cck 273 1 ( ( -LRB- cord-267475-6f4h3cck 273 2 Probst Probst NNP cord-267475-6f4h3cck 273 3 - - HYPH cord-267475-6f4h3cck 273 4 Kepper Kepper NNP cord-267475-6f4h3cck 273 5 et et FW cord-267475-6f4h3cck 273 6 al al NNP cord-267475-6f4h3cck 273 7 . . NNP cord-267475-6f4h3cck 273 8 , , , cord-267475-6f4h3cck 273 9 2001 2001 CD cord-267475-6f4h3cck 274 1 ; ; : cord-267475-6f4h3cck 274 2 Spotts Spotts NNP cord-267475-6f4h3cck 274 3 et et NNP cord-267475-6f4h3cck 274 4 al al NNP cord-267475-6f4h3cck 274 5 . . NNP cord-267475-6f4h3cck 274 6 , , , cord-267475-6f4h3cck 274 7 1997 1997 CD cord-267475-6f4h3cck 274 8 ) ) -RRB- cord-267475-6f4h3cck 274 9 . . . cord-267475-6f4h3cck 275 1 This this DT cord-267475-6f4h3cck 275 2 could could MD cord-267475-6f4h3cck 275 3 conceivably conceivably RB cord-267475-6f4h3cck 275 4 be be VB cord-267475-6f4h3cck 275 5 accomplished accomplish VBN cord-267475-6f4h3cck 275 6 via via IN cord-267475-6f4h3cck 275 7 proteins protein NNS cord-267475-6f4h3cck 275 8 that that WDT cord-267475-6f4h3cck 275 9 stabilize stabilize VBP cord-267475-6f4h3cck 275 10 downstream downstream JJ cord-267475-6f4h3cck 275 11 secondary secondary JJ cord-267475-6f4h3cck 275 12 structure structure NN cord-267475-6f4h3cck 275 13 or or CC cord-267475-6f4h3cck 275 14 , , , cord-267475-6f4h3cck 275 15 perhaps perhaps RB cord-267475-6f4h3cck 275 16 , , , cord-267475-6f4h3cck 275 17 via via IN cord-267475-6f4h3cck 275 18 a a DT cord-267475-6f4h3cck 275 19 combination combination NN cord-267475-6f4h3cck 275 20 of of IN cord-267475-6f4h3cck 275 21 leaky leaky JJ cord-267475-6f4h3cck 275 22 scanning scanning NN cord-267475-6f4h3cck 275 23 and and CC cord-267475-6f4h3cck 275 24 regulated regulated JJ cord-267475-6f4h3cck 275 25 reinitiation reinitiation NN cord-267475-6f4h3cck 275 26 , , , cord-267475-6f4h3cck 275 27 if if IN cord-267475-6f4h3cck 275 28 the the DT cord-267475-6f4h3cck 275 29 mRNA mRNA NNP cord-267475-6f4h3cck 275 30 also also RB cord-267475-6f4h3cck 275 31 has have VBZ cord-267475-6f4h3cck 275 32 small small JJ cord-267475-6f4h3cck 275 33 upORFs uporfs NN cord-267475-6f4h3cck 275 34 . . . cord-267475-6f4h3cck 276 1 Among among IN cord-267475-6f4h3cck 276 2 the the DT cord-267475-6f4h3cck 276 3 examples example NNS cord-267475-6f4h3cck 276 4 in in IN cord-267475-6f4h3cck 276 5 Table Table NNP cord-267475-6f4h3cck 276 6 3 3 CD cord-267475-6f4h3cck 276 7 are be VBP cord-267475-6f4h3cck 276 8 many many JJ cord-267475-6f4h3cck 276 9 plant plant NN cord-267475-6f4h3cck 276 10 viruses virus NNS cord-267475-6f4h3cck 276 11 , , , cord-267475-6f4h3cck 276 12 indicating indicate VBG cord-267475-6f4h3cck 276 13 that that IN cord-267475-6f4h3cck 276 14 the the DT cord-267475-6f4h3cck 276 15 basic basic JJ cord-267475-6f4h3cck 276 16 context context NN cord-267475-6f4h3cck 276 17 rules rule NNS cord-267475-6f4h3cck 276 18 extend extend VBP cord-267475-6f4h3cck 276 19 to to IN cord-267475-6f4h3cck 276 20 plant plant NN cord-267475-6f4h3cck 276 21 systems system NNS cord-267475-6f4h3cck 276 22 . . . cord-267475-6f4h3cck 277 1 Mutagenesis mutagenesis NN cord-267475-6f4h3cck 277 2 experiments experiment NNS cord-267475-6f4h3cck 277 3 confirm confirm VBP cord-267475-6f4h3cck 277 4 the the DT cord-267475-6f4h3cck 277 5 functional functional JJ cord-267475-6f4h3cck 277 6 importance importance NN cord-267475-6f4h3cck 277 7 of of IN cord-267475-6f4h3cck 277 8 R r NN cord-267475-6f4h3cck 277 9 in in IN cord-267475-6f4h3cck 277 10 position position NN cord-267475-6f4h3cck 277 11 23 23 CD cord-267475-6f4h3cck 277 12 and and CC cord-267475-6f4h3cck 277 13 G g NN cord-267475-6f4h3cck 277 14 in in IN cord-267475-6f4h3cck 277 15 position position NN cord-267475-6f4h3cck 277 16 þ þ NNP cord-267475-6f4h3cck 277 17 4 4 CD cord-267475-6f4h3cck 277 18 in in IN cord-267475-6f4h3cck 277 19 plant plant NN cord-267475-6f4h3cck 277 20 mRNAs mRNAs . cord-267475-6f4h3cck 278 1 ( ( -LRB- cord-267475-6f4h3cck 278 2 Jones Jones NNP cord-267475-6f4h3cck 278 3 et et NNP cord-267475-6f4h3cck 278 4 al al NNP cord-267475-6f4h3cck 278 5 . . NNP cord-267475-6f4h3cck 278 6 , , , cord-267475-6f4h3cck 278 7 1988 1988 CD cord-267475-6f4h3cck 279 1 ; ; : cord-267475-6f4h3cck 279 2 Lukaszewicz Lukaszewicz NNP cord-267475-6f4h3cck 279 3 et et NNP cord-267475-6f4h3cck 279 4 al al NNP cord-267475-6f4h3cck 279 5 . . NNP cord-267475-6f4h3cck 279 6 , , , cord-267475-6f4h3cck 279 7 2000 2000 CD cord-267475-6f4h3cck 279 8 ) ) -RRB- cord-267475-6f4h3cck 279 9 and and CC cord-267475-6f4h3cck 279 10 surveys survey NNS cord-267475-6f4h3cck 279 11 of of IN cord-267475-6f4h3cck 279 12 plant plant NN cord-267475-6f4h3cck 279 13 cDNA cdna NN cord-267475-6f4h3cck 279 14 sequences sequence NNS cord-267475-6f4h3cck 279 15 confirm confirm VBP cord-267475-6f4h3cck 279 16 the the DT cord-267475-6f4h3cck 279 17 conservation conservation NN cord-267475-6f4h3cck 279 18 of of IN cord-267475-6f4h3cck 279 19 those those DT cord-267475-6f4h3cck 279 20 key key JJ cord-267475-6f4h3cck 279 21 positions position NNS cord-267475-6f4h3cck 279 22 ( ( -LRB- cord-267475-6f4h3cck 279 23 Pesole Pesole NNP cord-267475-6f4h3cck 279 24 et et NNP cord-267475-6f4h3cck 279 25 al al NNP cord-267475-6f4h3cck 279 26 . . . cord-267475-6f4h3cck 280 1 , , , cord-267475-6f4h3cck 280 2 2000 2000 CD cord-267475-6f4h3cck 280 3 ; ; : cord-267475-6f4h3cck 280 4 Rogozin Rogozin NNP cord-267475-6f4h3cck 280 5 et et NNP cord-267475-6f4h3cck 280 6 al al NNP cord-267475-6f4h3cck 280 7 . . NNP cord-267475-6f4h3cck 280 8 , , , cord-267475-6f4h3cck 280 9 2001 2001 CD cord-267475-6f4h3cck 280 10 ) ) -RRB- cord-267475-6f4h3cck 280 11 . . . cord-267475-6f4h3cck 281 1 Unlike unlike IN cord-267475-6f4h3cck 281 2 mammalian mammalian NN cord-267475-6f4h3cck 281 3 mRNAs mrna NNS cord-267475-6f4h3cck 281 4 , , , cord-267475-6f4h3cck 281 5 however however RB cord-267475-6f4h3cck 281 6 , , , cord-267475-6f4h3cck 281 7 plant plant NN cord-267475-6f4h3cck 281 8 mRNAs mRNAs NNPS cord-267475-6f4h3cck 281 9 do do VBP cord-267475-6f4h3cck 281 10 not not RB cord-267475-6f4h3cck 281 11 show show VB cord-267475-6f4h3cck 281 12 a a DT cord-267475-6f4h3cck 281 13 predominance predominance NN cord-267475-6f4h3cck 281 14 of of IN cord-267475-6f4h3cck 281 15 C C NNP cord-267475-6f4h3cck 281 16 in in IN cord-267475-6f4h3cck 281 17 positions position NNS cord-267475-6f4h3cck 281 18 2 2 CD cord-267475-6f4h3cck 281 19 1 1 CD cord-267475-6f4h3cck 281 20 , , , cord-267475-6f4h3cck 281 21 2 2 CD cord-267475-6f4h3cck 281 22 2 2 CD cord-267475-6f4h3cck 281 23 , , , cord-267475-6f4h3cck 281 24 2 2 CD cord-267475-6f4h3cck 281 25 4 4 CD cord-267475-6f4h3cck 281 26 and and CC cord-267475-6f4h3cck 281 27 2 2 CD cord-267475-6f4h3cck 281 28 5 5 CD cord-267475-6f4h3cck 281 29 . . . cord-267475-6f4h3cck 282 1 The the DT cord-267475-6f4h3cck 282 2 foregoing forego VBG cord-267475-6f4h3cck 282 3 discussion discussion NN cord-267475-6f4h3cck 282 4 pertains pertain VBZ cord-267475-6f4h3cck 282 5 to to IN cord-267475-6f4h3cck 282 6 mRNAs mrnas PRP cord-267475-6f4h3cck 282 7 from from IN cord-267475-6f4h3cck 282 8 plants plant NNS cord-267475-6f4h3cck 282 9 and and CC cord-267475-6f4h3cck 282 10 vertebrate vertebrate JJ cord-267475-6f4h3cck 282 11 animals animal NNS cord-267475-6f4h3cck 282 12 . . . cord-267475-6f4h3cck 283 1 There there EX cord-267475-6f4h3cck 283 2 is be VBZ cord-267475-6f4h3cck 283 3 some some DT cord-267475-6f4h3cck 283 4 evidence evidence NN cord-267475-6f4h3cck 283 5 for for IN cord-267475-6f4h3cck 283 6 contextdependent contextdependent JJ cord-267475-6f4h3cck 283 7 leaky leaky JJ cord-267475-6f4h3cck 283 8 scanning scanning NN cord-267475-6f4h3cck 283 9 in in IN cord-267475-6f4h3cck 283 10 fungi fungus NNS cord-267475-6f4h3cck 283 11 ( ( -LRB- cord-267475-6f4h3cck 283 12 Arst Arst NNP cord-267475-6f4h3cck 283 13 and and CC cord-267475-6f4h3cck 283 14 Sheerins Sheerins NNP cord-267475-6f4h3cck 283 15 , , , cord-267475-6f4h3cck 283 16 1996 1996 CD cord-267475-6f4h3cck 283 17 ) ) -RRB- cord-267475-6f4h3cck 283 18 , , , cord-267475-6f4h3cck 283 19 but but CC cord-267475-6f4h3cck 283 20 context context NN cord-267475-6f4h3cck 283 21 effects effect NNS cord-267475-6f4h3cck 283 22 on on IN cord-267475-6f4h3cck 283 23 initiation initiation NN cord-267475-6f4h3cck 283 24 have have VBP cord-267475-6f4h3cck 283 25 not not RB cord-267475-6f4h3cck 283 26 yet yet RB cord-267475-6f4h3cck 283 27 been be VBN cord-267475-6f4h3cck 283 28 studied study VBN cord-267475-6f4h3cck 283 29 carefully carefully RB cord-267475-6f4h3cck 283 30 in in IN cord-267475-6f4h3cck 283 31 protozoa protozoan NNS cord-267475-6f4h3cck 283 32 , , , cord-267475-6f4h3cck 283 33 insects insect NNS cord-267475-6f4h3cck 283 34 , , , cord-267475-6f4h3cck 283 35 and and CC cord-267475-6f4h3cck 283 36 various various JJ cord-267475-6f4h3cck 283 37 other other JJ cord-267475-6f4h3cck 283 38 systems system NNS cord-267475-6f4h3cck 283 39 . . . cord-267475-6f4h3cck 284 1 The the DT cord-267475-6f4h3cck 284 2 observation observation NN cord-267475-6f4h3cck 284 3 that that IN cord-267475-6f4h3cck 284 4 trans trans NN cord-267475-6f4h3cck 284 5 - - NN cord-267475-6f4h3cck 284 6 splicing splicing NN cord-267475-6f4h3cck 284 7 of of IN cord-267475-6f4h3cck 284 8 mRNAs mRNAs NNPS cord-267475-6f4h3cck 284 9 in in IN cord-267475-6f4h3cck 284 10 C. C. NNP cord-267475-6f4h3cck 284 11 elegans elegan NNS cord-267475-6f4h3cck 284 12 sometimes sometimes RB cord-267475-6f4h3cck 284 13 brings bring VBZ cord-267475-6f4h3cck 284 14 a a DT cord-267475-6f4h3cck 284 15 purine purine NN cord-267475-6f4h3cck 284 16 into into IN cord-267475-6f4h3cck 284 17 position position NN cord-267475-6f4h3cck 284 18 2 2 CD cord-267475-6f4h3cck 284 19 3 3 CD cord-267475-6f4h3cck 284 20 is be VBZ cord-267475-6f4h3cck 284 21 interesting interesting JJ cord-267475-6f4h3cck 285 1 ( ( -LRB- cord-267475-6f4h3cck 285 2 Hough Hough NNP cord-267475-6f4h3cck 285 3 et et NNP cord-267475-6f4h3cck 285 4 al al NNP cord-267475-6f4h3cck 285 5 . . NNP cord-267475-6f4h3cck 285 6 , , , cord-267475-6f4h3cck 285 7 1999 1999 CD cord-267475-6f4h3cck 285 8 ) ) -RRB- cord-267475-6f4h3cck 286 1 but but CC cord-267475-6f4h3cck 286 2 the the DT cord-267475-6f4h3cck 286 3 significance significance NN cord-267475-6f4h3cck 286 4 awaits await VBZ cord-267475-6f4h3cck 286 5 testing testing NN cord-267475-6f4h3cck 286 6 . . . cord-267475-6f4h3cck 287 1 With with IN cord-267475-6f4h3cck 287 2 a a DT cord-267475-6f4h3cck 287 3 number number NN cord-267475-6f4h3cck 287 4 of of IN cord-267475-6f4h3cck 287 5 yeast yeast NN cord-267475-6f4h3cck 287 6 genes gene NNS cord-267475-6f4h3cck 287 7 , , , cord-267475-6f4h3cck 287 8 there there EX cord-267475-6f4h3cck 287 9 is be VBZ cord-267475-6f4h3cck 287 10 a a DT cord-267475-6f4h3cck 287 11 hint hint NN cord-267475-6f4h3cck 287 12 of of IN cord-267475-6f4h3cck 287 13 leaky leaky JJ cord-267475-6f4h3cck 287 14 scanning scanning NN cord-267475-6f4h3cck 287 15 when when WRB cord-267475-6f4h3cck 287 16 the the DT cord-267475-6f4h3cck 287 17 usual usual JJ cord-267475-6f4h3cck 287 18 A a NN cord-267475-6f4h3cck 287 19 in in IN cord-267475-6f4h3cck 287 20 position position NN cord-267475-6f4h3cck 287 21 2 2 CD cord-267475-6f4h3cck 287 22 3 3 CD cord-267475-6f4h3cck 287 23 is be VBZ cord-267475-6f4h3cck 287 24 replaced replace VBN cord-267475-6f4h3cck 287 25 by by IN cord-267475-6f4h3cck 287 26 a a DT cord-267475-6f4h3cck 287 27 pyrimidine pyrimidine NN cord-267475-6f4h3cck 287 28 ( ( -LRB- cord-267475-6f4h3cck 287 29 Gaba Gaba NNP cord-267475-6f4h3cck 287 30 et et FW cord-267475-6f4h3cck 287 31 al al NNP cord-267475-6f4h3cck 287 32 . . NNP cord-267475-6f4h3cck 287 33 , , , cord-267475-6f4h3cck 287 34 2001 2001 CD cord-267475-6f4h3cck 287 35 ; ; : cord-267475-6f4h3cck 287 36 Slusher Slusher NNP cord-267475-6f4h3cck 287 37 et et NNP cord-267475-6f4h3cck 287 38 al al NNP cord-267475-6f4h3cck 287 39 . . NNP cord-267475-6f4h3cck 287 40 , , , cord-267475-6f4h3cck 287 41 1991 1991 CD cord-267475-6f4h3cck 287 42 ; ; : cord-267475-6f4h3cck 288 1 Vilela Vilela NNP cord-267475-6f4h3cck 288 2 et et FW cord-267475-6f4h3cck 288 3 al al NNP cord-267475-6f4h3cck 288 4 . . NNP cord-267475-6f4h3cck 288 5 , , , cord-267475-6f4h3cck 288 6 1998 1998 CD cord-267475-6f4h3cck 288 7 ; ; : cord-267475-6f4h3cck 288 8 Welch Welch NNP cord-267475-6f4h3cck 288 9 and and CC cord-267475-6f4h3cck 288 10 Jacobson Jacobson NNP cord-267475-6f4h3cck 288 11 , , , cord-267475-6f4h3cck 288 12 1999 1999 CD cord-267475-6f4h3cck 288 13 ; ; : cord-267475-6f4h3cck 288 14 Wolfe Wolfe NNP cord-267475-6f4h3cck 288 15 et et NNP cord-267475-6f4h3cck 288 16 al al NNP cord-267475-6f4h3cck 288 17 . . NNP cord-267475-6f4h3cck 288 18 , , , cord-267475-6f4h3cck 288 19 1994 1994 CD cord-267475-6f4h3cck 288 20 ) ) -RRB- cord-267475-6f4h3cck 288 21 . . . cord-267475-6f4h3cck 289 1 Context context JJ cord-267475-6f4h3cck 289 2 effects effect NNS cord-267475-6f4h3cck 289 3 were be VBD cord-267475-6f4h3cck 289 4 not not RB cord-267475-6f4h3cck 289 5 evident evident JJ cord-267475-6f4h3cck 289 6 , , , cord-267475-6f4h3cck 289 7 however however RB cord-267475-6f4h3cck 289 8 , , , cord-267475-6f4h3cck 289 9 in in IN cord-267475-6f4h3cck 289 10 other other JJ cord-267475-6f4h3cck 289 11 studies study NNS cord-267475-6f4h3cck 289 12 of of IN cord-267475-6f4h3cck 289 13 translation translation NN cord-267475-6f4h3cck 289 14 in in IN cord-267475-6f4h3cck 289 15 yeast yeast NN cord-267475-6f4h3cck 290 1 ( ( -LRB- cord-267475-6f4h3cck 290 2 Cigan Cigan NNP cord-267475-6f4h3cck 290 3 et et FW cord-267475-6f4h3cck 290 4 al al NNP cord-267475-6f4h3cck 290 5 . . . cord-267475-6f4h3cck 291 1 , , , cord-267475-6f4h3cck 291 2 1988b 1988b CD cord-267475-6f4h3cck 291 3 ) ) -RRB- cord-267475-6f4h3cck 291 4 . . . cord-267475-6f4h3cck 292 1 For for IN cord-267475-6f4h3cck 292 2 whatever whatever WDT cord-267475-6f4h3cck 292 3 reason reason NN cord-267475-6f4h3cck 292 4 , , , cord-267475-6f4h3cck 292 5 leaky leaky JJ cord-267475-6f4h3cck 292 6 scanning scanning NN cord-267475-6f4h3cck 292 7 is be VBZ cord-267475-6f4h3cck 292 8 rare rare JJ cord-267475-6f4h3cck 292 9 in in IN cord-267475-6f4h3cck 292 10 yeast yeast NN cord-267475-6f4h3cck 292 11 , , , cord-267475-6f4h3cck 292 12 apart apart RB cord-267475-6f4h3cck 292 13 from from IN cord-267475-6f4h3cck 292 14 a a DT cord-267475-6f4h3cck 292 15 few few JJ cord-267475-6f4h3cck 292 16 cases case NNS cord-267475-6f4h3cck 292 17 attributable attributable JJ cord-267475-6f4h3cck 292 18 to to IN cord-267475-6f4h3cck 292 19 the the DT cord-267475-6f4h3cck 292 20 first first JJ cord-267475-6f4h3cck 292 21 AUG AUG NNP cord-267475-6f4h3cck 292 22 codon codon NN cord-267475-6f4h3cck 292 23 residing reside VBG cord-267475-6f4h3cck 292 24 too too RB cord-267475-6f4h3cck 292 25 close close RB cord-267475-6f4h3cck 292 26 to to IN cord-267475-6f4h3cck 292 27 the the DT cord-267475-6f4h3cck 292 28 5 5 CD cord-267475-6f4h3cck 292 29 0 0 CD cord-267475-6f4h3cck 292 30 end end NN cord-267475-6f4h3cck 292 31 . . . cord-267475-6f4h3cck 293 1 mRNAs mrnas LS cord-267475-6f4h3cck 293 2 that that WDT cord-267475-6f4h3cck 293 3 initiate initiate VBP cord-267475-6f4h3cck 293 4 translation translation NN cord-267475-6f4h3cck 293 5 from from IN cord-267475-6f4h3cck 293 6 three three CD cord-267475-6f4h3cck 293 7 sites site NNS cord-267475-6f4h3cck 293 8 provide provide VBP cord-267475-6f4h3cck 293 9 a a DT cord-267475-6f4h3cck 293 10 striking striking JJ cord-267475-6f4h3cck 293 11 illustration illustration NN cord-267475-6f4h3cck 293 12 of of IN cord-267475-6f4h3cck 293 13 how how WRB cord-267475-6f4h3cck 293 14 far far RB cord-267475-6f4h3cck 293 15 leaky leaky JJ cord-267475-6f4h3cck 293 16 scanning scanning NN cord-267475-6f4h3cck 293 17 , , , cord-267475-6f4h3cck 293 18 alone alone RB cord-267475-6f4h3cck 293 19 or or CC cord-267475-6f4h3cck 293 20 in in IN cord-267475-6f4h3cck 293 21 combination combination NN cord-267475-6f4h3cck 293 22 with with IN cord-267475-6f4h3cck 293 23 reinitiation reinitiation NN cord-267475-6f4h3cck 293 24 , , , cord-267475-6f4h3cck 293 25 can can MD cord-267475-6f4h3cck 293 26 be be VB cord-267475-6f4h3cck 293 27 pushed push VBN cord-267475-6f4h3cck 293 28 . . . cord-267475-6f4h3cck 294 1 Fig Fig NNP cord-267475-6f4h3cck 294 2 . . NNP cord-267475-6f4h3cck 294 3 1 1 CD cord-267475-6f4h3cck 294 4 shows show VBZ cord-267475-6f4h3cck 294 5 some some DT cord-267475-6f4h3cck 294 6 examples example NNS cord-267475-6f4h3cck 294 7 . . . cord-267475-6f4h3cck 295 1 The the DT cord-267475-6f4h3cck 295 2 predominant predominant JJ cord-267475-6f4h3cck 295 3 translation translation NN cord-267475-6f4h3cck 295 4 product product NN cord-267475-6f4h3cck 295 5 obtained obtain VBN cord-267475-6f4h3cck 295 6 from from IN cord-267475-6f4h3cck 295 7 cmyc cmyc NNP cord-267475-6f4h3cck 296 1 mRNA mRNA NNP cord-267475-6f4h3cck 296 2 is be VBZ cord-267475-6f4h3cck 296 3 a a DT cord-267475-6f4h3cck 296 4 65 65 CD cord-267475-6f4h3cck 296 5 kDa kDa NNP cord-267475-6f4h3cck 296 6 ' ' POS cord-267475-6f4h3cck 296 7 long long JJ cord-267475-6f4h3cck 296 8 form form NN cord-267475-6f4h3cck 296 9 2 2 CD cord-267475-6f4h3cck 296 10 ' ' '' cord-267475-6f4h3cck 296 11 which which WDT cord-267475-6f4h3cck 296 12 initiates initiate VBZ cord-267475-6f4h3cck 296 13 at at IN cord-267475-6f4h3cck 296 14 the the DT cord-267475-6f4h3cck 296 15 first first JJ cord-267475-6f4h3cck 296 16 AUG AUG NNP cord-267475-6f4h3cck 296 17 codon codon NN cord-267475-6f4h3cck 296 18 ( ( -LRB- cord-267475-6f4h3cck 296 19 Fig Fig NNP cord-267475-6f4h3cck 296 20 . . . cord-267475-6f4h3cck 296 21 1A 1a NN cord-267475-6f4h3cck 296 22 ) ) -RRB- cord-267475-6f4h3cck 296 23 . . . cord-267475-6f4h3cck 297 1 A a DT cord-267475-6f4h3cck 297 2 small small JJ cord-267475-6f4h3cck 297 3 amount amount NN cord-267475-6f4h3cck 297 4 of of IN cord-267475-6f4h3cck 297 5 a a DT cord-267475-6f4h3cck 297 6 longer long JJR cord-267475-6f4h3cck 297 7 isoform isoform NN cord-267475-6f4h3cck 297 8 ( ( -LRB- cord-267475-6f4h3cck 297 9 68 68 CD cord-267475-6f4h3cck 297 10 kDa kDa NNS cord-267475-6f4h3cck 297 11 ) ) -RRB- cord-267475-6f4h3cck 297 12 derives derive VBZ cord-267475-6f4h3cck 297 13 from from IN cord-267475-6f4h3cck 297 14 an an DT cord-267475-6f4h3cck 297 15 upstream upstream JJ cord-267475-6f4h3cck 297 16 CUG CUG NNP cord-267475-6f4h3cck 297 17 codon codon NN cord-267475-6f4h3cck 297 18 which which WDT cord-267475-6f4h3cck 297 19 is be VBZ cord-267475-6f4h3cck 297 20 a a DT cord-267475-6f4h3cck 297 21 weak weak JJ cord-267475-6f4h3cck 297 22 start start NN cord-267475-6f4h3cck 297 23 site site NN cord-267475-6f4h3cck 297 24 ( ( -LRB- cord-267475-6f4h3cck 297 25 i.e. i.e. FW cord-267475-6f4h3cck 297 26 very very RB cord-267475-6f4h3cck 297 27 leaky leaky JJ cord-267475-6f4h3cck 297 28 ) ) -RRB- cord-267475-6f4h3cck 297 29 because because IN cord-267475-6f4h3cck 297 30 the the DT cord-267475-6f4h3cck 297 31 codon codon NN cord-267475-6f4h3cck 297 32 is be VBZ cord-267475-6f4h3cck 297 33 not not RB cord-267475-6f4h3cck 297 34 AUG AUG NNP cord-267475-6f4h3cck 297 35 . . . cord-267475-6f4h3cck 298 1 Although although IN cord-267475-6f4h3cck 298 2 the the DT cord-267475-6f4h3cck 298 3 first first JJ cord-267475-6f4h3cck 298 4 AUG AUG NNP cord-267475-6f4h3cck 298 5 codon codon NN cord-267475-6f4h3cck 298 6 has have VBZ cord-267475-6f4h3cck 298 7 the the DT cord-267475-6f4h3cck 298 8 required require VBN cord-267475-6f4h3cck 298 9 A a NN cord-267475-6f4h3cck 298 10 in in IN cord-267475-6f4h3cck 298 11 position position NN cord-267475-6f4h3cck 298 12 2 2 CD cord-267475-6f4h3cck 298 13 3 3 CD cord-267475-6f4h3cck 298 14 , , , cord-267475-6f4h3cck 298 15 a a DT cord-267475-6f4h3cck 298 16 small small JJ cord-267475-6f4h3cck 298 17 percentage percentage NN cord-267475-6f4h3cck 298 18 of of IN cord-267475-6f4h3cck 298 19 ribosomes ribosome NNS cord-267475-6f4h3cck 298 20 bypass bypass NN cord-267475-6f4h3cck 298 21 that that DT cord-267475-6f4h3cck 298 22 site site NN cord-267475-6f4h3cck 298 23 and and CC cord-267475-6f4h3cck 298 24 initiate initiate VB cord-267475-6f4h3cck 298 25 at at IN cord-267475-6f4h3cck 298 26 the the DT cord-267475-6f4h3cck 298 27 next next JJ cord-267475-6f4h3cck 298 28 AUG AUG NNP cord-267475-6f4h3cck 298 29 , , , cord-267475-6f4h3cck 298 30 producing produce VBG cord-267475-6f4h3cck 298 31 a a DT cord-267475-6f4h3cck 298 32 third third JJ cord-267475-6f4h3cck 298 33 ( ( -LRB- cord-267475-6f4h3cck 298 34 50 50 CD cord-267475-6f4h3cck 298 35 kDa kDa NNS cord-267475-6f4h3cck 298 36 ) ) -RRB- cord-267475-6f4h3cck 298 37 form form NN cord-267475-6f4h3cck 298 38 of of IN cord-267475-6f4h3cck 298 39 c c NN cord-267475-6f4h3cck 298 40 - - HYPH cord-267475-6f4h3cck 298 41 myc myc NNP cord-267475-6f4h3cck 298 42 . . . cord-267475-6f4h3cck 299 1 This this DT cord-267475-6f4h3cck 299 2 happens happen VBZ cord-267475-6f4h3cck 299 3 apparently apparently RB cord-267475-6f4h3cck 299 4 because because IN cord-267475-6f4h3cck 299 5 the the DT cord-267475-6f4h3cck 299 6 context context NN cord-267475-6f4h3cck 299 7 flanking flank VBG cord-267475-6f4h3cck 299 8 the the DT cord-267475-6f4h3cck 299 9 first first JJ cord-267475-6f4h3cck 299 10 AUG AUG NNP cord-267475-6f4h3cck 299 11 codon codon NN cord-267475-6f4h3cck 299 12 is be VBZ cord-267475-6f4h3cck 299 13 good good JJ cord-267475-6f4h3cck 299 14 but but CC cord-267475-6f4h3cck 299 15 not not RB cord-267475-6f4h3cck 299 16 perfect perfect JJ cord-267475-6f4h3cck 299 17 . . . cord-267475-6f4h3cck 300 1 Thus thus RB cord-267475-6f4h3cck 300 2 , , , cord-267475-6f4h3cck 300 3 production production NN cord-267475-6f4h3cck 300 4 of of IN cord-267475-6f4h3cck 300 5 the the DT cord-267475-6f4h3cck 300 6 50 50 CD cord-267475-6f4h3cck 300 7 kDa kDa NNPS cord-267475-6f4h3cck 300 8 isoform isoform NN cord-267475-6f4h3cck 300 9 was be VBD cord-267475-6f4h3cck 300 10 eliminated eliminate VBN cord-267475-6f4h3cck 300 11 when when WRB cord-267475-6f4h3cck 300 12 the the DT cord-267475-6f4h3cck 300 13 upstream upstream JJ cord-267475-6f4h3cck 300 14 site site NN cord-267475-6f4h3cck 300 15 was be VBD cord-267475-6f4h3cck 300 16 changed change VBN cord-267475-6f4h3cck 300 17 from from IN cord-267475-6f4h3cck 300 18 ACGaugC ACGaugC NNP cord-267475-6f4h3cck 300 19 to to IN cord-267475-6f4h3cck 300 20 ACCaugG ACCaugG . cord-267475-6f4h3cck 301 1 ( ( -LRB- cord-267475-6f4h3cck 301 2 Spotts Spotts NNP cord-267475-6f4h3cck 301 3 et et FW cord-267475-6f4h3cck 301 4 al al NNP cord-267475-6f4h3cck 301 5 . . NNP cord-267475-6f4h3cck 301 6 , , , cord-267475-6f4h3cck 301 7 1997 1997 CD cord-267475-6f4h3cck 301 8 ) ) -RRB- cord-267475-6f4h3cck 301 9 . . . cord-267475-6f4h3cck 302 1 Fig Fig NNP cord-267475-6f4h3cck 302 2 . . . cord-267475-6f4h3cck 303 1 1B 1B NNP cord-267475-6f4h3cck 303 2 depicts depict VBZ cord-267475-6f4h3cck 303 3 another another DT cord-267475-6f4h3cck 303 4 example example NN cord-267475-6f4h3cck 303 5 in in IN cord-267475-6f4h3cck 303 6 which which WDT cord-267475-6f4h3cck 303 7 ribosomes ribosome NNS cord-267475-6f4h3cck 303 8 initiate initiate VBP cord-267475-6f4h3cck 303 9 from from IN cord-267475-6f4h3cck 303 10 three three CD cord-267475-6f4h3cck 303 11 in in IN cord-267475-6f4h3cck 303 12 - - HYPH cord-267475-6f4h3cck 303 13 frame frame NN cord-267475-6f4h3cck 303 14 AUG AUG NNP cord-267475-6f4h3cck 303 15 codons codon NNS cord-267475-6f4h3cck 303 16 . . . cord-267475-6f4h3cck 304 1 With with IN cord-267475-6f4h3cck 304 2 the the DT cord-267475-6f4h3cck 304 3 mRNA mrna NN cord-267475-6f4h3cck 304 4 that that WDT cord-267475-6f4h3cck 304 5 encodes encode VBZ cord-267475-6f4h3cck 304 6 C C NNP cord-267475-6f4h3cck 304 7 / / SYM cord-267475-6f4h3cck 304 8 EBPb EBPb NNS cord-267475-6f4h3cck 304 9 , , , cord-267475-6f4h3cck 304 10 access access NN cord-267475-6f4h3cck 304 11 to to IN cord-267475-6f4h3cck 304 12 the the DT cord-267475-6f4h3cck 304 13 far far JJ cord-267475-6f4h3cck 304 14 downstream downstream JJ cord-267475-6f4h3cck 304 15 site site NN cord-267475-6f4h3cck 304 16 via via IN cord-267475-6f4h3cck 304 17 leaky leaky JJ cord-267475-6f4h3cck 304 18 scanning scanning NN cord-267475-6f4h3cck 304 19 is be VBZ cord-267475-6f4h3cck 304 20 augmented augment VBN cord-267475-6f4h3cck 304 21 by by IN cord-267475-6f4h3cck 304 22 a a DT cord-267475-6f4h3cck 304 23 reinitiation reinitiation NN cord-267475-6f4h3cck 304 24 shunt shunt NN cord-267475-6f4h3cck 304 25 , , , cord-267475-6f4h3cck 304 26 as as IN cord-267475-6f4h3cck 304 27 explained explain VBN cord-267475-6f4h3cck 304 28 in in IN cord-267475-6f4h3cck 304 29 the the DT cord-267475-6f4h3cck 304 30 legend legend NN cord-267475-6f4h3cck 304 31 to to IN cord-267475-6f4h3cck 304 32 Fig Fig NNP cord-267475-6f4h3cck 304 33 . . . cord-267475-6f4h3cck 305 1 1 1 CD cord-267475-6f4h3cck 305 2 and and CC cord-267475-6f4h3cck 305 3 discussed discuss VBN cord-267475-6f4h3cck 305 4 further further RB cord-267475-6f4h3cck 305 5 in in IN cord-267475-6f4h3cck 305 6 Section section NN cord-267475-6f4h3cck 305 7 4 4 CD cord-267475-6f4h3cck 305 8 . . . cord-267475-6f4h3cck 306 1 Translation translation NN cord-267475-6f4h3cck 306 2 of of IN cord-267475-6f4h3cck 306 3 C C NNP cord-267475-6f4h3cck 306 4 / / SYM cord-267475-6f4h3cck 306 5 EBPa EBPa NNS cord-267475-6f4h3cck 306 6 mRNA mrna NN cord-267475-6f4h3cck 306 7 occurs occur VBZ cord-267475-6f4h3cck 306 8 by by IN cord-267475-6f4h3cck 306 9 a a DT cord-267475-6f4h3cck 306 10 mechanism mechanism NN cord-267475-6f4h3cck 306 11 similar similar JJ cord-267475-6f4h3cck 306 12 to to IN cord-267475-6f4h3cck 306 13 that that DT cord-267475-6f4h3cck 306 14 depicted depict VBN cord-267475-6f4h3cck 306 15 for for IN cord-267475-6f4h3cck 306 16 C C NNP cord-267475-6f4h3cck 306 17 / / SYM cord-267475-6f4h3cck 306 18 EBPb EBPb NNS cord-267475-6f4h3cck 306 19 except except IN cord-267475-6f4h3cck 306 20 that that IN cord-267475-6f4h3cck 306 21 the the DT cord-267475-6f4h3cck 306 22 first first JJ cord-267475-6f4h3cck 306 23 start start NN cord-267475-6f4h3cck 306 24 site site NN cord-267475-6f4h3cck 306 25 in in IN cord-267475-6f4h3cck 306 26 C C NNP cord-267475-6f4h3cck 306 27 / / SYM cord-267475-6f4h3cck 306 28 EBPa EBPa NNS cord-267475-6f4h3cck 306 29 is be VBZ cord-267475-6f4h3cck 306 30 a a DT cord-267475-6f4h3cck 306 31 CUG CUG NNP cord-267475-6f4h3cck 306 32 codon codon NN cord-267475-6f4h3cck 306 33 ( ( -LRB- cord-267475-6f4h3cck 306 34 Calkhoven Calkhoven NNP cord-267475-6f4h3cck 306 35 et et NNP cord-267475-6f4h3cck 306 36 al al NNP cord-267475-6f4h3cck 306 37 . . NNP cord-267475-6f4h3cck 306 38 , , , cord-267475-6f4h3cck 306 39 2000 2000 CD cord-267475-6f4h3cck 306 40 ) ) -RRB- cord-267475-6f4h3cck 306 41 , , , cord-267475-6f4h3cck 306 42 which which WDT cord-267475-6f4h3cck 306 43 generates generate VBZ cord-267475-6f4h3cck 306 44 a a DT cord-267475-6f4h3cck 306 45 smaller small JJR cord-267475-6f4h3cck 306 46 amount amount NN cord-267475-6f4h3cck 306 47 of of IN cord-267475-6f4h3cck 306 48 the the DT cord-267475-6f4h3cck 306 49 longest long JJS cord-267475-6f4h3cck 306 50 protein protein NN cord-267475-6f4h3cck 306 51 ( ( -LRB- cord-267475-6f4h3cck 306 52 isoform isoform NN cord-267475-6f4h3cck 306 53 A A NNP cord-267475-6f4h3cck 306 54 ) ) -RRB- cord-267475-6f4h3cck 306 55 than than IN cord-267475-6f4h3cck 306 56 does do VBZ cord-267475-6f4h3cck 306 57 the the DT cord-267475-6f4h3cck 306 58 AUG AUG NNP cord-267475-6f4h3cck 306 59 codon codon NN cord-267475-6f4h3cck 306 60 in in IN cord-267475-6f4h3cck 306 61 C/ C/ NNP cord-267475-6f4h3cck 306 62 EBPb EBPb NNS cord-267475-6f4h3cck 306 63 . . . cord-267475-6f4h3cck 307 1 With with IN cord-267475-6f4h3cck 307 2 c c NNP cord-267475-6f4h3cck 307 3 - - HYPH cord-267475-6f4h3cck 307 4 myc myc NNP cord-267475-6f4h3cck 307 5 , , , cord-267475-6f4h3cck 307 6 C C NNP cord-267475-6f4h3cck 307 7 / / SYM cord-267475-6f4h3cck 307 8 EBPb EBPb NNP cord-267475-6f4h3cck 307 9 and and CC cord-267475-6f4h3cck 307 10 C C NNP cord-267475-6f4h3cck 307 11 / / SYM cord-267475-6f4h3cck 307 12 EBPa EBPa NNS cord-267475-6f4h3cck 307 13 mRNAs mRNAs NNPS cord-267475-6f4h3cck 307 14 , , , cord-267475-6f4h3cck 307 15 leaky leaky JJ cord-267475-6f4h3cck 307 16 scanning scanning NN cord-267475-6f4h3cck 307 17 is be VBZ cord-267475-6f4h3cck 307 18 biologically biologically RB cord-267475-6f4h3cck 307 19 important important JJ cord-267475-6f4h3cck 307 20 because because IN cord-267475-6f4h3cck 307 21 the the DT cord-267475-6f4h3cck 307 22 long long JJ cord-267475-6f4h3cck 307 23 and and CC cord-267475-6f4h3cck 307 24 short short JJ cord-267475-6f4h3cck 307 25 versions version NNS cord-267475-6f4h3cck 307 26 of of IN cord-267475-6f4h3cck 307 27 the the DT cord-267475-6f4h3cck 307 28 protein protein NN cord-267475-6f4h3cck 307 29 have have VBP cord-267475-6f4h3cck 307 30 opposing oppose VBG cord-267475-6f4h3cck 307 31 effects effect NNS cord-267475-6f4h3cck 307 32 as as IN cord-267475-6f4h3cck 307 33 regulators regulator NNS cord-267475-6f4h3cck 307 34 of of IN cord-267475-6f4h3cck 307 35 transcription transcription NN cord-267475-6f4h3cck 307 36 . . . cord-267475-6f4h3cck 308 1 It -PRON- PRP cord-267475-6f4h3cck 308 2 is be VBZ cord-267475-6f4h3cck 308 3 striking strike VBG cord-267475-6f4h3cck 308 4 that that IN cord-267475-6f4h3cck 308 5 leaky leaky JJ cord-267475-6f4h3cck 308 6 scanning scanning NN cord-267475-6f4h3cck 308 7 can can MD cord-267475-6f4h3cck 308 8 operate operate VB cord-267475-6f4h3cck 308 9 even even RB cord-267475-6f4h3cck 308 10 when when WRB cord-267475-6f4h3cck 308 11 the the DT cord-267475-6f4h3cck 308 12 second second JJ cord-267475-6f4h3cck 308 13 initiation initiation NN cord-267475-6f4h3cck 308 14 site site NN cord-267475-6f4h3cck 308 15 resides reside VBZ cord-267475-6f4h3cck 308 16 far far RB cord-267475-6f4h3cck 308 17 downstream downstream RB cord-267475-6f4h3cck 308 18 from from IN cord-267475-6f4h3cck 308 19 the the DT cord-267475-6f4h3cck 308 20 first first JJ cord-267475-6f4h3cck 308 21 . . . cord-267475-6f4h3cck 309 1 With with IN cord-267475-6f4h3cck 309 2 synthetic synthetic JJ cord-267475-6f4h3cck 309 3 transcripts transcript NNS cord-267475-6f4h3cck 309 4 designed design VBN cord-267475-6f4h3cck 309 5 to to TO cord-267475-6f4h3cck 309 6 test test VB cord-267475-6f4h3cck 309 7 the the DT cord-267475-6f4h3cck 309 8 processivity processivity NN cord-267475-6f4h3cck 309 9 of of IN cord-267475-6f4h3cck 309 10 scanning scanning NN cord-267475-6f4h3cck 309 11 , , , cord-267475-6f4h3cck 309 12 there there EX cord-267475-6f4h3cck 309 13 was be VBD cord-267475-6f4h3cck 309 14 no no DT cord-267475-6f4h3cck 309 15 reduction reduction NN cord-267475-6f4h3cck 309 16 in in IN cord-267475-6f4h3cck 309 17 initiation initiation NN cord-267475-6f4h3cck 309 18 from from IN cord-267475-6f4h3cck 309 19 the the DT cord-267475-6f4h3cck 309 20 downstream downstream JJ cord-267475-6f4h3cck 309 21 site site NN cord-267475-6f4h3cck 309 22 when when WRB cord-267475-6f4h3cck 309 23 the the DT cord-267475-6f4h3cck 309 24 inter inter JJ cord-267475-6f4h3cck 309 25 - - JJ cord-267475-6f4h3cck 309 26 AUG AUG NNP cord-267475-6f4h3cck 309 27 distance distance NN cord-267475-6f4h3cck 309 28 was be VBD cord-267475-6f4h3cck 309 29 expanded expand VBN cord-267475-6f4h3cck 309 30 stepwise stepwise RB cord-267475-6f4h3cck 309 31 from from IN cord-267475-6f4h3cck 309 32 11 11 CD cord-267475-6f4h3cck 309 33 to to IN cord-267475-6f4h3cck 309 34 251 251 CD cord-267475-6f4h3cck 309 35 nt nt NN cord-267475-6f4h3cck 309 36 ( ( -LRB- cord-267475-6f4h3cck 309 37 Kozak Kozak NNP cord-267475-6f4h3cck 309 38 , , , cord-267475-6f4h3cck 309 39 1998 1998 CD cord-267475-6f4h3cck 309 40 ) ) -RRB- cord-267475-6f4h3cck 309 41 . . . cord-267475-6f4h3cck 310 1 In in IN cord-267475-6f4h3cck 310 2 some some DT cord-267475-6f4h3cck 310 3 remarkable remarkable JJ cord-267475-6f4h3cck 310 4 viral viral NN cord-267475-6f4h3cck 310 5 mRNAs mRNAs NNPS cord-267475-6f4h3cck 310 6 , , , cord-267475-6f4h3cck 310 7 the the DT cord-267475-6f4h3cck 310 8 second second JJ cord-267475-6f4h3cck 310 9 functional functional JJ cord-267475-6f4h3cck 310 10 initiation initiation NN cord-267475-6f4h3cck 310 11 site site NN cord-267475-6f4h3cck 310 12 is be VBZ cord-267475-6f4h3cck 310 13 more more JJR cord-267475-6f4h3cck 310 14 than than IN cord-267475-6f4h3cck 310 15 500 500 CD cord-267475-6f4h3cck 310 16 nt nt RB cord-267475-6f4h3cck 310 17 downstream downstream RB cord-267475-6f4h3cck 310 18 from from IN cord-267475-6f4h3cck 310 19 the the DT cord-267475-6f4h3cck 310 20 Fig Fig NNP cord-267475-6f4h3cck 310 21 . . . cord-267475-6f4h3cck 311 1 1 1 LS cord-267475-6f4h3cck 311 2 . . . cord-267475-6f4h3cck 312 1 Examples example NNS cord-267475-6f4h3cck 312 2 of of IN cord-267475-6f4h3cck 312 3 ' ' `` cord-267475-6f4h3cck 312 4 maximally maximally RB cord-267475-6f4h3cck 312 5 leaky leaky JJ cord-267475-6f4h3cck 312 6 ' ' '' cord-267475-6f4h3cck 312 7 scanning scanning NN cord-267475-6f4h3cck 313 1 wherein wherein WRB cord-267475-6f4h3cck 313 2 one one CD cord-267475-6f4h3cck 313 3 mRNA mrna NN cord-267475-6f4h3cck 313 4 produces produce VBZ cord-267475-6f4h3cck 313 5 three three CD cord-267475-6f4h3cck 313 6 independently independently RB cord-267475-6f4h3cck 313 7 initiated initiate VBN cord-267475-6f4h3cck 313 8 proteins protein NNS cord-267475-6f4h3cck 313 9 . . . cord-267475-6f4h3cck 314 1 Major major JJ cord-267475-6f4h3cck 314 2 ( ( -LRB- cord-267475-6f4h3cck 314 3 thick thick JJ cord-267475-6f4h3cck 314 4 arrow arrow NN cord-267475-6f4h3cck 314 5 ) ) -RRB- cord-267475-6f4h3cck 314 6 and and CC cord-267475-6f4h3cck 314 7 minor minor JJ cord-267475-6f4h3cck 314 8 ( ( -LRB- cord-267475-6f4h3cck 314 9 thin thin JJ cord-267475-6f4h3cck 314 10 arrow arrow NN cord-267475-6f4h3cck 314 11 ) ) -RRB- cord-267475-6f4h3cck 314 12 translation translation NN cord-267475-6f4h3cck 314 13 products product NNS cord-267475-6f4h3cck 314 14 are be VBP cord-267475-6f4h3cck 314 15 identified identify VBN cord-267475-6f4h3cck 314 16 below below IN cord-267475-6f4h3cck 314 17 their -PRON- PRP$ cord-267475-6f4h3cck 314 18 respective respective JJ cord-267475-6f4h3cck 314 19 start start NN cord-267475-6f4h3cck 314 20 codons codon NNS cord-267475-6f4h3cck 314 21 . . . cord-267475-6f4h3cck 315 1 Sequences sequence NNS cord-267475-6f4h3cck 315 2 that that WDT cord-267475-6f4h3cck 315 3 cause cause VBP cord-267475-6f4h3cck 315 4 the the DT cord-267475-6f4h3cck 315 5 initiation initiation NN cord-267475-6f4h3cck 315 6 site site NN cord-267475-6f4h3cck 315 7 to to TO cord-267475-6f4h3cck 315 8 be be VB cord-267475-6f4h3cck 315 9 weak weak JJ cord-267475-6f4h3cck 315 10 , , , cord-267475-6f4h3cck 315 11 and and CC cord-267475-6f4h3cck 315 12 thus thus RB cord-267475-6f4h3cck 315 13 promote promote VB cord-267475-6f4h3cck 315 14 leaky leaky JJ cord-267475-6f4h3cck 315 15 scanning scanning NN cord-267475-6f4h3cck 315 16 , , , cord-267475-6f4h3cck 315 17 are be VBP cord-267475-6f4h3cck 315 18 highlighted highlight VBN cord-267475-6f4h3cck 315 19 in in IN cord-267475-6f4h3cck 315 20 red red NN cord-267475-6f4h3cck 315 21 . . . cord-267475-6f4h3cck 316 1 Offset offset NN cord-267475-6f4h3cck 316 2 rectangles rectangle NNS cord-267475-6f4h3cck 316 3 represent represent VBP cord-267475-6f4h3cck 316 4 ORFs ORFs NNP cord-267475-6f4h3cck 316 5 in in IN cord-267475-6f4h3cck 316 6 different different JJ cord-267475-6f4h3cck 316 7 reading reading NN cord-267475-6f4h3cck 316 8 frames frame NNS cord-267475-6f4h3cck 316 9 . . . cord-267475-6f4h3cck 317 1 ( ( -LRB- cord-267475-6f4h3cck 317 2 A a NN cord-267475-6f4h3cck 317 3 ) ) -RRB- cord-267475-6f4h3cck 317 4 With with IN cord-267475-6f4h3cck 317 5 c c NNP cord-267475-6f4h3cck 317 6 - - HYPH cord-267475-6f4h3cck 317 7 myc myc NNP cord-267475-6f4h3cck 317 8 mRNA mRNA NNP cord-267475-6f4h3cck 317 9 , , , cord-267475-6f4h3cck 317 10 a a DT cord-267475-6f4h3cck 317 11 leaky leaky JJ cord-267475-6f4h3cck 317 12 scanning scanning NN cord-267475-6f4h3cck 317 13 mechanism mechanism NN cord-267475-6f4h3cck 317 14 was be VBD cord-267475-6f4h3cck 317 15 inferred infer VBN cord-267475-6f4h3cck 317 16 from from IN cord-267475-6f4h3cck 317 17 experiments experiment NNS cord-267475-6f4h3cck 317 18 in in IN cord-267475-6f4h3cck 317 19 which which WDT cord-267475-6f4h3cck 317 20 optimizing optimize VBG cord-267475-6f4h3cck 317 21 the the DT cord-267475-6f4h3cck 317 22 context context NN cord-267475-6f4h3cck 317 23 around around IN cord-267475-6f4h3cck 317 24 the the DT cord-267475-6f4h3cck 317 25 first first JJ cord-267475-6f4h3cck 317 26 AUG AUG NNP cord-267475-6f4h3cck 317 27 codon codon NN cord-267475-6f4h3cck 317 28 suppressed suppress VBD cord-267475-6f4h3cck 317 29 production production NN cord-267475-6f4h3cck 317 30 of of IN cord-267475-6f4h3cck 317 31 the the DT cord-267475-6f4h3cck 317 32 50 50 CD cord-267475-6f4h3cck 317 33 kDa kDa NNP cord-267475-6f4h3cck 317 34 isoform isoform NN cord-267475-6f4h3cck 317 35 , , , cord-267475-6f4h3cck 317 36 while while IN cord-267475-6f4h3cck 317 37 changing change VBG cord-267475-6f4h3cck 317 38 the the DT cord-267475-6f4h3cck 317 39 upstream upstream JJ cord-267475-6f4h3cck 317 40 CUG CUG NNP cord-267475-6f4h3cck 317 41 codon codon NN cord-267475-6f4h3cck 317 42 to to IN cord-267475-6f4h3cck 317 43 AUG AUG NNP cord-267475-6f4h3cck 317 44 suppressed suppress VBD cord-267475-6f4h3cck 317 45 production production NN cord-267475-6f4h3cck 317 46 of of IN cord-267475-6f4h3cck 317 47 both both CC cord-267475-6f4h3cck 317 48 the the DT cord-267475-6f4h3cck 317 49 65 65 CD cord-267475-6f4h3cck 317 50 and and CC cord-267475-6f4h3cck 317 51 50 50 CD cord-267475-6f4h3cck 317 52 kDa kDa NNS cord-267475-6f4h3cck 317 53 isoforms isoform NNS cord-267475-6f4h3cck 317 54 ( ( -LRB- cord-267475-6f4h3cck 317 55 Spotts Spotts NNP cord-267475-6f4h3cck 317 56 et et FW cord-267475-6f4h3cck 317 57 al al NNP cord-267475-6f4h3cck 317 58 . . NNP cord-267475-6f4h3cck 317 59 , , , cord-267475-6f4h3cck 317 60 1997 1997 CD cord-267475-6f4h3cck 317 61 ) ) -RRB- cord-267475-6f4h3cck 317 62 . . . cord-267475-6f4h3cck 318 1 Access access NN cord-267475-6f4h3cck 318 2 to to IN cord-267475-6f4h3cck 318 3 the the DT cord-267475-6f4h3cck 318 4 downstream downstream JJ cord-267475-6f4h3cck 318 5 start start NN cord-267475-6f4h3cck 318 6 site site NN cord-267475-6f4h3cck 318 7 might may MD cord-267475-6f4h3cck 318 8 be be VB cord-267475-6f4h3cck 318 9 more more RBR cord-267475-6f4h3cck 318 10 complicated complicated JJ cord-267475-6f4h3cck 318 11 than than IN cord-267475-6f4h3cck 318 12 here here RB cord-267475-6f4h3cck 318 13 depicted depict VBN cord-267475-6f4h3cck 318 14 , , , cord-267475-6f4h3cck 318 15 as as IN cord-267475-6f4h3cck 318 16 there there EX cord-267475-6f4h3cck 318 17 is be VBZ cord-267475-6f4h3cck 318 18 a a DT cord-267475-6f4h3cck 318 19 small small JJ cord-267475-6f4h3cck 318 20 out out NN cord-267475-6f4h3cck 318 21 - - HYPH cord-267475-6f4h3cck 318 22 of of IN cord-267475-6f4h3cck 318 23 - - HYPH cord-267475-6f4h3cck 318 24 frame frame NN cord-267475-6f4h3cck 318 25 ORF ORF NNP cord-267475-6f4h3cck 318 26 between between IN cord-267475-6f4h3cck 318 27 the the DT cord-267475-6f4h3cck 318 28 65 65 CD cord-267475-6f4h3cck 318 29 and and CC cord-267475-6f4h3cck 318 30 50 50 CD cord-267475-6f4h3cck 318 31 kDa kDa NNPS cord-267475-6f4h3cck 318 32 start start VBP cord-267475-6f4h3cck 318 33 sites site NNS cord-267475-6f4h3cck 318 34 . . . cord-267475-6f4h3cck 319 1 ( ( -LRB- cord-267475-6f4h3cck 319 2 B b NN cord-267475-6f4h3cck 319 3 ) ) -RRB- cord-267475-6f4h3cck 320 1 With with IN cord-267475-6f4h3cck 320 2 C C NNP cord-267475-6f4h3cck 320 3 / / SYM cord-267475-6f4h3cck 320 4 EBPb EBPb NNP cord-267475-6f4h3cck 320 5 mRNA mRNA NNP cord-267475-6f4h3cck 320 6 , , , cord-267475-6f4h3cck 320 7 a a DT cord-267475-6f4h3cck 320 8 mutation mutation NN cord-267475-6f4h3cck 320 9 that that WDT cord-267475-6f4h3cck 320 10 strengthens strengthen VBZ cord-267475-6f4h3cck 320 11 the the DT cord-267475-6f4h3cck 320 12 first first JJ cord-267475-6f4h3cck 320 13 start start NN cord-267475-6f4h3cck 320 14 codon codon NN cord-267475-6f4h3cck 320 15 ( ( -LRB- cord-267475-6f4h3cck 320 16 UUCaugC UUCaugC NNP cord-267475-6f4h3cck 320 17 ! ! . cord-267475-6f4h3cck 320 18 ACCaugG accaugg RB cord-267475-6f4h3cck 320 19 ) ) -RRB- cord-267475-6f4h3cck 320 20 blocked block VBN cord-267475-6f4h3cck 320 21 production production NN cord-267475-6f4h3cck 320 22 of of IN cord-267475-6f4h3cck 320 23 all all DT cord-267475-6f4h3cck 320 24 shorter short JJR cord-267475-6f4h3cck 320 25 isoforms isoform NNS cord-267475-6f4h3cck 320 26 , , , cord-267475-6f4h3cck 320 27 implicating implicate VBG cord-267475-6f4h3cck 320 28 a a DT cord-267475-6f4h3cck 320 29 leaky leaky JJ cord-267475-6f4h3cck 320 30 scanning scanning NN cord-267475-6f4h3cck 320 31 mechanism mechanism NN cord-267475-6f4h3cck 320 32 ( ( -LRB- cord-267475-6f4h3cck 320 33 Calkhoven Calkhoven NNP cord-267475-6f4h3cck 320 34 et et NNP cord-267475-6f4h3cck 320 35 al al NNP cord-267475-6f4h3cck 320 36 . . NNP cord-267475-6f4h3cck 320 37 , , , cord-267475-6f4h3cck 320 38 2000 2000 CD cord-267475-6f4h3cck 320 39 ) ) -RRB- cord-267475-6f4h3cck 320 40 . . . cord-267475-6f4h3cck 321 1 A a DT cord-267475-6f4h3cck 321 2 small small JJ cord-267475-6f4h3cck 321 3 upORF uporf JJ cord-267475-6f4h3cck 321 4 ( ( -LRB- cord-267475-6f4h3cck 321 5 blue blue NNP cord-267475-6f4h3cck 321 6 ) ) -RRB- cord-267475-6f4h3cck 321 7 superimposes superimpose VBZ cord-267475-6f4h3cck 321 8 another another DT cord-267475-6f4h3cck 321 9 level level NN cord-267475-6f4h3cck 321 10 of of IN cord-267475-6f4h3cck 321 11 control control NN cord-267475-6f4h3cck 321 12 , , , cord-267475-6f4h3cck 321 13 causing cause VBG cord-267475-6f4h3cck 321 14 more more JJR cord-267475-6f4h3cck 321 15 ribosomes ribosome NNS cord-267475-6f4h3cck 321 16 to to TO cord-267475-6f4h3cck 321 17 bypass bypass VB cord-267475-6f4h3cck 321 18 the the DT cord-267475-6f4h3cck 321 19 start start NN cord-267475-6f4h3cck 321 20 site site NN cord-267475-6f4h3cck 321 21 for for IN cord-267475-6f4h3cck 321 22 isoform isoform NN cord-267475-6f4h3cck 321 23 B1 b1 NN cord-267475-6f4h3cck 321 24 than than IN cord-267475-6f4h3cck 321 25 would would MD cord-267475-6f4h3cck 321 26 be be VB cord-267475-6f4h3cck 321 27 expected expect VBN cord-267475-6f4h3cck 321 28 from from IN cord-267475-6f4h3cck 321 29 leaky leaky JJ cord-267475-6f4h3cck 321 30 scanning scanning NN cord-267475-6f4h3cck 321 31 alone alone RB cord-267475-6f4h3cck 321 32 . . . cord-267475-6f4h3cck 322 1 Presumably presumably RB cord-267475-6f4h3cck 322 2 because because IN cord-267475-6f4h3cck 322 3 the the DT cord-267475-6f4h3cck 322 4 AUG AUG NNP cord-267475-6f4h3cck 322 5 START START NNP cord-267475-6f4h3cck 322 6 codon codon NN cord-267475-6f4h3cck 322 7 for for IN cord-267475-6f4h3cck 322 8 isoform isoform NN cord-267475-6f4h3cck 322 9 B1 b1 NN cord-267475-6f4h3cck 322 10 is be VBZ cord-267475-6f4h3cck 322 11 positioned position VBN cord-267475-6f4h3cck 322 12 close close RB cord-267475-6f4h3cck 322 13 to to IN cord-267475-6f4h3cck 322 14 the the DT cord-267475-6f4h3cck 322 15 termination termination NN cord-267475-6f4h3cck 322 16 site site NN cord-267475-6f4h3cck 322 17 of of IN cord-267475-6f4h3cck 322 18 the the DT cord-267475-6f4h3cck 322 19 upORF uporf JJ cord-267475-6f4h3cck 322 20 , , , cord-267475-6f4h3cck 322 21 reinitiation reinitiation NN cord-267475-6f4h3cck 322 22 at at IN cord-267475-6f4h3cck 322 23 site site NN cord-267475-6f4h3cck 322 24 B1 b1 NN cord-267475-6f4h3cck 322 25 is be VBZ cord-267475-6f4h3cck 322 26 inefficient inefficient JJ cord-267475-6f4h3cck 322 27 and and CC cord-267475-6f4h3cck 322 28 some some DT cord-267475-6f4h3cck 322 29 ribosomes ribosome NNS cord-267475-6f4h3cck 322 30 thus thus RB cord-267475-6f4h3cck 322 31 reach reach VBP cord-267475-6f4h3cck 322 32 the the DT cord-267475-6f4h3cck 322 33 far far JJ cord-267475-6f4h3cck 322 34 downstream downstream JJ cord-267475-6f4h3cck 322 35 start start NN cord-267475-6f4h3cck 322 36 site site NN cord-267475-6f4h3cck 322 37 for for IN cord-267475-6f4h3cck 322 38 the the DT cord-267475-6f4h3cck 322 39 20 20 CD cord-267475-6f4h3cck 322 40 kDa kDa NNP cord-267475-6f4h3cck 322 41 isoform isoform NN cord-267475-6f4h3cck 322 42 ( ( -LRB- cord-267475-6f4h3cck 322 43 LIP lip NN cord-267475-6f4h3cck 322 44 ) ) -RRB- cord-267475-6f4h3cck 322 45 . . . cord-267475-6f4h3cck 323 1 As as IN cord-267475-6f4h3cck 323 2 evidence evidence NN cord-267475-6f4h3cck 323 3 for for IN cord-267475-6f4h3cck 323 4 this this DT cord-267475-6f4h3cck 323 5 reinitiation reinitiation NN cord-267475-6f4h3cck 323 6 shunt shunt NN cord-267475-6f4h3cck 323 7 , , , cord-267475-6f4h3cck 323 8 Calkhoven Calkhoven NNP cord-267475-6f4h3cck 323 9 et et NNP cord-267475-6f4h3cck 323 10 al al NNP cord-267475-6f4h3cck 323 11 . . . cord-267475-6f4h3cck 324 1 ( ( -LRB- cord-267475-6f4h3cck 324 2 2000 2000 CD cord-267475-6f4h3cck 324 3 ) ) -RRB- cord-267475-6f4h3cck 324 4 showed show VBD cord-267475-6f4h3cck 324 5 that that IN cord-267475-6f4h3cck 324 6 eliminating eliminate VBG cord-267475-6f4h3cck 324 7 the the DT cord-267475-6f4h3cck 324 8 AUG AUG NNP cord-267475-6f4h3cck 324 9 codon codon NN cord-267475-6f4h3cck 324 10 of of IN cord-267475-6f4h3cck 324 11 the the DT cord-267475-6f4h3cck 324 12 upORF uporf JJ cord-267475-6f4h3cck 324 13 abolished abolished JJ cord-267475-6f4h3cck 324 14 production production NN cord-267475-6f4h3cck 324 15 of of IN cord-267475-6f4h3cck 324 16 LIP lip NN cord-267475-6f4h3cck 324 17 and and CC cord-267475-6f4h3cck 324 18 that that IN cord-267475-6f4h3cck 324 19 strengthening strengthen VBG cord-267475-6f4h3cck 324 20 or or CC cord-267475-6f4h3cck 324 21 weakening weaken VBG cord-267475-6f4h3cck 324 22 the the DT cord-267475-6f4h3cck 324 23 context context NN cord-267475-6f4h3cck 324 24 around around IN cord-267475-6f4h3cck 324 25 the the DT cord-267475-6f4h3cck 324 26 upORF uporf JJ cord-267475-6f4h3cck 324 27 start start NN cord-267475-6f4h3cck 324 28 codon codon NN cord-267475-6f4h3cck 324 29 caused cause VBD cord-267475-6f4h3cck 324 30 corresponding correspond VBG cord-267475-6f4h3cck 324 31 changes change NNS cord-267475-6f4h3cck 324 32 in in IN cord-267475-6f4h3cck 324 33 the the DT cord-267475-6f4h3cck 324 34 yield yield NN cord-267475-6f4h3cck 324 35 of of IN cord-267475-6f4h3cck 324 36 LIP lip NN cord-267475-6f4h3cck 324 37 . . . cord-267475-6f4h3cck 325 1 Although although IN cord-267475-6f4h3cck 325 2 the the DT cord-267475-6f4h3cck 325 3 smallest small JJS cord-267475-6f4h3cck 325 4 form form NN cord-267475-6f4h3cck 325 5 of of IN cord-267475-6f4h3cck 325 6 C C NNP cord-267475-6f4h3cck 325 7 / / SYM cord-267475-6f4h3cck 325 8 EBPb EBPb NNS cord-267475-6f4h3cck 325 9 can can MD cord-267475-6f4h3cck 325 10 be be VB cord-267475-6f4h3cck 325 11 generated generate VBN cord-267475-6f4h3cck 325 12 in in IN cord-267475-6f4h3cck 325 13 some some DT cord-267475-6f4h3cck 325 14 situations situation NNS cord-267475-6f4h3cck 325 15 by by IN cord-267475-6f4h3cck 325 16 proteolysis proteolysis NN cord-267475-6f4h3cck 325 17 ( ( -LRB- cord-267475-6f4h3cck 325 18 Dearth Dearth NNP cord-267475-6f4h3cck 325 19 et et FW cord-267475-6f4h3cck 325 20 al al NNP cord-267475-6f4h3cck 325 21 . . NNP cord-267475-6f4h3cck 325 22 , , , cord-267475-6f4h3cck 325 23 2001 2001 CD cord-267475-6f4h3cck 325 24 ) ) -RRB- cord-267475-6f4h3cck 325 25 , , , cord-267475-6f4h3cck 325 26 the the DT cord-267475-6f4h3cck 325 27 effects effect NNS cord-267475-6f4h3cck 325 28 of of IN cord-267475-6f4h3cck 325 29 the the DT cord-267475-6f4h3cck 325 30 aforementioned aforementioned JJ cord-267475-6f4h3cck 325 31 mutations mutation NNS cord-267475-6f4h3cck 325 32 clearly clearly RB cord-267475-6f4h3cck 325 33 implicate implicate VBP cord-267475-6f4h3cck 325 34 a a DT cord-267475-6f4h3cck 325 35 translational translational JJ cord-267475-6f4h3cck 325 36 mechanism mechanism NN cord-267475-6f4h3cck 325 37 . . . cord-267475-6f4h3cck 326 1 The the DT cord-267475-6f4h3cck 326 2 LAP LAP NNP cord-267475-6f4h3cck 326 3 / / SYM cord-267475-6f4h3cck 326 4 LIP lip NN cord-267475-6f4h3cck 326 5 ratio ratio NN cord-267475-6f4h3cck 326 6 shows show VBZ cord-267475-6f4h3cck 326 7 tissue tissue NN cord-267475-6f4h3cck 326 8 and and CC cord-267475-6f4h3cck 326 9 stage stage VB cord-267475-6f4h3cck 326 10 specific specific JJ cord-267475-6f4h3cck 326 11 variation variation NN cord-267475-6f4h3cck 327 1 ( ( -LRB- cord-267475-6f4h3cck 327 2 Dearth Dearth NNP cord-267475-6f4h3cck 327 3 et et NNP cord-267475-6f4h3cck 327 4 al al NNP cord-267475-6f4h3cck 327 5 . . NNP cord-267475-6f4h3cck 327 6 , , , cord-267475-6f4h3cck 327 7 2001 2001 CD cord-267475-6f4h3cck 327 8 ; ; : cord-267475-6f4h3cck 328 1 Descombes Descombes NNP cord-267475-6f4h3cck 328 2 and and CC cord-267475-6f4h3cck 328 3 Schibler Schibler NNP cord-267475-6f4h3cck 328 4 , , , cord-267475-6f4h3cck 328 5 1991 1991 CD cord-267475-6f4h3cck 328 6 ) ) -RRB- cord-267475-6f4h3cck 328 7 . . . cord-267475-6f4h3cck 329 1 ( ( -LRB- cord-267475-6f4h3cck 329 2 C C NNP cord-267475-6f4h3cck 329 3 ) ) -RRB- cord-267475-6f4h3cck 330 1 Whereas whereas IN cord-267475-6f4h3cck 330 2 leaky leaky JJ cord-267475-6f4h3cck 330 3 scanning scanning NN cord-267475-6f4h3cck 330 4 allows allow VBZ cord-267475-6f4h3cck 330 5 initiation initiation NN cord-267475-6f4h3cck 330 6 at at IN cord-267475-6f4h3cck 330 7 multiple multiple JJ cord-267475-6f4h3cck 330 8 sites site NNS cord-267475-6f4h3cck 330 9 within within IN cord-267475-6f4h3cck 330 10 a a DT cord-267475-6f4h3cck 330 11 single single JJ cord-267475-6f4h3cck 330 12 ORF orf NN cord-267475-6f4h3cck 330 13 in in IN cord-267475-6f4h3cck 330 14 C C NNP cord-267475-6f4h3cck 330 15 / / SYM cord-267475-6f4h3cck 330 16 EBPb EBPb NNS cord-267475-6f4h3cck 330 17 and and CC cord-267475-6f4h3cck 330 18 c c NNP cord-267475-6f4h3cck 330 19 - - HYPH cord-267475-6f4h3cck 330 20 myc myc NNP cord-267475-6f4h3cck 330 21 mRNAs mRNAs NNPS cord-267475-6f4h3cck 330 22 , , , cord-267475-6f4h3cck 330 23 leaky leaky JJ cord-267475-6f4h3cck 330 24 scanning scanning NN cord-267475-6f4h3cck 330 25 allows allow VBZ cord-267475-6f4h3cck 330 26 translation translation NN cord-267475-6f4h3cck 330 27 of of IN cord-267475-6f4h3cck 330 28 three three CD cord-267475-6f4h3cck 330 29 separate separate JJ cord-267475-6f4h3cck 330 30 ORFs orfs NN cord-267475-6f4h3cck 330 31 in in IN cord-267475-6f4h3cck 330 32 the the DT cord-267475-6f4h3cck 330 33 pregenomic pregenomic NNP cord-267475-6f4h3cck 330 34 mRNA mrna NN cord-267475-6f4h3cck 330 35 of of IN cord-267475-6f4h3cck 330 36 rice rice NNP cord-267475-6f4h3cck 330 37 tungro tungro NNP cord-267475-6f4h3cck 330 38 bacilliform bacilliform NNP cord-267475-6f4h3cck 330 39 virus virus NN cord-267475-6f4h3cck 330 40 . . . cord-267475-6f4h3cck 331 1 These these DT cord-267475-6f4h3cck 331 2 ORFs orf NNS cord-267475-6f4h3cck 331 3 ( ( -LRB- cord-267475-6f4h3cck 331 4 not not RB cord-267475-6f4h3cck 331 5 drawn draw VBN cord-267475-6f4h3cck 331 6 to to TO cord-267475-6f4h3cck 331 7 scale scale VB cord-267475-6f4h3cck 331 8 ) ) -RRB- cord-267475-6f4h3cck 331 9 have have VB cord-267475-6f4h3cck 331 10 overlapping overlap VBG cord-267475-6f4h3cck 331 11 start start VB cord-267475-6f4h3cck 331 12 and and CC cord-267475-6f4h3cck 331 13 stop stop VB cord-267475-6f4h3cck 331 14 codons codon NNS cord-267475-6f4h3cck 331 15 of of IN cord-267475-6f4h3cck 331 16 the the DT cord-267475-6f4h3cck 331 17 form form NN cord-267475-6f4h3cck 331 18 AUGA AUGA NNP cord-267475-6f4h3cck 331 19 . . . cord-267475-6f4h3cck 332 1 Translation translation NN cord-267475-6f4h3cck 332 2 via via IN cord-267475-6f4h3cck 332 3 leaky leaky JJ cord-267475-6f4h3cck 332 4 scanning scanning NN cord-267475-6f4h3cck 332 5 was be VBD cord-267475-6f4h3cck 332 6 inferred infer VBN cord-267475-6f4h3cck 332 7 from from IN cord-267475-6f4h3cck 332 8 the the DT cord-267475-6f4h3cck 332 9 strong strong JJ cord-267475-6f4h3cck 332 10 reduction reduction NN cord-267475-6f4h3cck 332 11 ( ( -LRB- cord-267475-6f4h3cck 332 12 .13-fold .13-fold . cord-267475-6f4h3cck 332 13 ) ) -RRB- cord-267475-6f4h3cck 333 1 in in IN cord-267475-6f4h3cck 333 2 translation translation NN cord-267475-6f4h3cck 333 3 of of IN cord-267475-6f4h3cck 333 4 ORF2 ORF2 NNP cord-267475-6f4h3cck 333 5 and and CC cord-267475-6f4h3cck 333 6 ORF3 ORF3 NNP cord-267475-6f4h3cck 333 7 when when WRB cord-267475-6f4h3cck 333 8 the the DT cord-267475-6f4h3cck 333 9 start start NN cord-267475-6f4h3cck 333 10 codon codon NN cord-267475-6f4h3cck 333 11 of of IN cord-267475-6f4h3cck 333 12 ORF1 ORF1 NNP cord-267475-6f4h3cck 333 13 was be VBD cord-267475-6f4h3cck 333 14 changed change VBN cord-267475-6f4h3cck 333 15 from from IN cord-267475-6f4h3cck 333 16 AUU AUU NNP cord-267475-6f4h3cck 333 17 to to IN cord-267475-6f4h3cck 333 18 AUG AUG NNP cord-267475-6f4h3cck 334 1 ( ( -LRB- cord-267475-6f4h3cck 334 2 Fütterer Fütterer NNP cord-267475-6f4h3cck 334 3 et et FW cord-267475-6f4h3cck 334 4 al al NNP cord-267475-6f4h3cck 334 5 . . NNP cord-267475-6f4h3cck 334 6 , , , cord-267475-6f4h3cck 334 7 1997 1997 CD cord-267475-6f4h3cck 334 8 ) ) -RRB- cord-267475-6f4h3cck 334 9 and and CC cord-267475-6f4h3cck 334 10 from from IN cord-267475-6f4h3cck 334 11 the the DT cord-267475-6f4h3cck 334 12 inhibitory inhibitory JJ cord-267475-6f4h3cck 334 13 effect effect NN cord-267475-6f4h3cck 334 14 on on IN cord-267475-6f4h3cck 334 15 expression expression NN cord-267475-6f4h3cck 334 16 of of IN cord-267475-6f4h3cck 334 17 ORF3 ORF3 NNP cord-267475-6f4h3cck 334 18 when when WRB cord-267475-6f4h3cck 334 19 an an DT cord-267475-6f4h3cck 334 20 adventitious adventitious JJ cord-267475-6f4h3cck 334 21 AUG AUG NNP cord-267475-6f4h3cck 334 22 codon codon NN cord-267475-6f4h3cck 334 23 was be VBD cord-267475-6f4h3cck 334 24 inserted insert VBN cord-267475-6f4h3cck 334 25 into into IN cord-267475-6f4h3cck 334 26 ORF2 ORF2 NNP cord-267475-6f4h3cck 334 27 . . . cord-267475-6f4h3cck 335 1 The the DT cord-267475-6f4h3cck 335 2 5 5 CD cord-267475-6f4h3cck 335 3 0 0 CD cord-267475-6f4h3cck 335 4 leader leader NN cord-267475-6f4h3cck 335 5 sequence sequence NN cord-267475-6f4h3cck 335 6 that that WDT cord-267475-6f4h3cck 335 7 precedes precede VBZ cord-267475-6f4h3cck 335 8 ORF1 ORF1 NNP cord-267475-6f4h3cck 335 9 has have VBZ cord-267475-6f4h3cck 335 10 ten ten CD cord-267475-6f4h3cck 335 11 small small JJ cord-267475-6f4h3cck 335 12 upORFs uporfs NN cord-267475-6f4h3cck 335 13 which which WDT cord-267475-6f4h3cck 335 14 are be VBP cord-267475-6f4h3cck 335 15 not not RB cord-267475-6f4h3cck 335 16 depicted depict VBN cord-267475-6f4h3cck 335 17 here here RB cord-267475-6f4h3cck 335 18 because because IN cord-267475-6f4h3cck 335 19 that that DT cord-267475-6f4h3cck 335 20 peculiar peculiar JJ cord-267475-6f4h3cck 335 21 leader leader NN cord-267475-6f4h3cck 335 22 sequence sequence NN cord-267475-6f4h3cck 335 23 , , , cord-267475-6f4h3cck 335 24 postulated postulate VBN cord-267475-6f4h3cck 335 25 to to TO cord-267475-6f4h3cck 335 26 be be VB cord-267475-6f4h3cck 335 27 translated translate VBN cord-267475-6f4h3cck 335 28 by by IN cord-267475-6f4h3cck 335 29 ribosome ribosome NN cord-267475-6f4h3cck 335 30 hopping hopping NN cord-267475-6f4h3cck 336 1 ( ( -LRB- cord-267475-6f4h3cck 336 2 Fütterer Fütterer NNP cord-267475-6f4h3cck 336 3 et et FW cord-267475-6f4h3cck 336 4 al al NNP cord-267475-6f4h3cck 336 5 . . NNP cord-267475-6f4h3cck 336 6 , , , cord-267475-6f4h3cck 336 7 1996 1996 CD cord-267475-6f4h3cck 336 8 ) ) -RRB- cord-267475-6f4h3cck 336 9 , , , cord-267475-6f4h3cck 336 10 is be VBZ cord-267475-6f4h3cck 336 11 not not RB cord-267475-6f4h3cck 336 12 required require VBN cord-267475-6f4h3cck 336 13 for for IN cord-267475-6f4h3cck 336 14 the the DT cord-267475-6f4h3cck 336 15 leaky leaky JJ cord-267475-6f4h3cck 336 16 scanning scanning NN cord-267475-6f4h3cck 336 17 mechanism mechanism NN cord-267475-6f4h3cck 336 18 that that WDT cord-267475-6f4h3cck 336 19 underlies underlie VBZ cord-267475-6f4h3cck 336 20 translation translation NN cord-267475-6f4h3cck 336 21 of of IN cord-267475-6f4h3cck 336 22 ORFs ORFs NNP cord-267475-6f4h3cck 336 23 1 1 CD cord-267475-6f4h3cck 336 24 , , , cord-267475-6f4h3cck 336 25 2 2 CD cord-267475-6f4h3cck 336 26 and and CC cord-267475-6f4h3cck 336 27 3 3 CD cord-267475-6f4h3cck 336 28 . . . cord-267475-6f4h3cck 337 1 ( ( -LRB- cord-267475-6f4h3cck 337 2 D d NN cord-267475-6f4h3cck 337 3 ) ) -RRB- cord-267475-6f4h3cck 338 1 The the DT cord-267475-6f4h3cck 338 2 avian avian JJ cord-267475-6f4h3cck 338 3 reovirus reovirus NNP cord-267475-6f4h3cck 338 4 S1 S1 NNP cord-267475-6f4h3cck 338 5 mRNA mRNA NNP cord-267475-6f4h3cck 338 6 supports support VBZ cord-267475-6f4h3cck 338 7 translation translation NN cord-267475-6f4h3cck 338 8 of of IN cord-267475-6f4h3cck 338 9 one one CD cord-267475-6f4h3cck 338 10 structural structural JJ cord-267475-6f4h3cck 338 11 and and CC cord-267475-6f4h3cck 338 12 two two CD cord-267475-6f4h3cck 338 13 nonstructural nonstructural JJ cord-267475-6f4h3cck 338 14 proteins protein NNS cord-267475-6f4h3cck 339 1 ( ( -LRB- cord-267475-6f4h3cck 339 2 Bodelón Bodelón NNP cord-267475-6f4h3cck 339 3 et et NNP cord-267475-6f4h3cck 339 4 al al NNP cord-267475-6f4h3cck 339 5 . . NNP cord-267475-6f4h3cck 339 6 , , , cord-267475-6f4h3cck 339 7 2001 2001 CD cord-267475-6f4h3cck 339 8 ) ) -RRB- cord-267475-6f4h3cck 339 9 . . . cord-267475-6f4h3cck 340 1 The the DT cord-267475-6f4h3cck 340 2 depicted depict VBN cord-267475-6f4h3cck 340 3 mechanism mechanism NN cord-267475-6f4h3cck 340 4 postulates postulate VBZ cord-267475-6f4h3cck 340 5 that that IN cord-267475-6f4h3cck 340 6 ORF1 ORF1 NNP cord-267475-6f4h3cck 340 7 has have VBZ cord-267475-6f4h3cck 340 8 a a DT cord-267475-6f4h3cck 340 9 dual dual JJ cord-267475-6f4h3cck 340 10 function function NN cord-267475-6f4h3cck 340 11 , , , cord-267475-6f4h3cck 340 12 encoding encode VBG cord-267475-6f4h3cck 340 13 its -PRON- PRP$ cord-267475-6f4h3cck 340 14 own own JJ cord-267475-6f4h3cck 340 15 polypeptide polypeptide NN cord-267475-6f4h3cck 340 16 ( ( -LRB- cord-267475-6f4h3cck 340 17 p10 p10 NN cord-267475-6f4h3cck 340 18 ) ) -RRB- cord-267475-6f4h3cck 340 19 and and CC cord-267475-6f4h3cck 340 20 facilitating facilitate VBG cord-267475-6f4h3cck 340 21 translation translation NN cord-267475-6f4h3cck 340 22 of of IN cord-267475-6f4h3cck 340 23 ORF3 ORF3 NNP cord-267475-6f4h3cck 340 24 by by IN cord-267475-6f4h3cck 340 25 shunting shunt VBG cord-267475-6f4h3cck 340 26 some some DT cord-267475-6f4h3cck 340 27 ribosomes ribosome NNS cord-267475-6f4h3cck 340 28 past past IN cord-267475-6f4h3cck 340 29 the the DT cord-267475-6f4h3cck 340 30 strong strong JJ cord-267475-6f4h3cck 340 31 AUG AUG NNP cord-267475-6f4h3cck 340 32 START START NNP cord-267475-6f4h3cck 340 33 codon codon NN cord-267475-6f4h3cck 340 34 for for IN cord-267475-6f4h3cck 340 35 ORF2 ORF2 NNP cord-267475-6f4h3cck 340 36 . . . cord-267475-6f4h3cck 341 1 The the DT cord-267475-6f4h3cck 341 2 absence absence NN cord-267475-6f4h3cck 341 3 of of IN cord-267475-6f4h3cck 341 4 extraneous extraneous JJ cord-267475-6f4h3cck 341 5 AUG AUG NNP cord-267475-6f4h3cck 341 6 codons codon NNS cord-267475-6f4h3cck 341 7 in in IN cord-267475-6f4h3cck 341 8 the the DT cord-267475-6f4h3cck 341 9 310 310 CD cord-267475-6f4h3cck 341 10 nt nt NN cord-267475-6f4h3cck 341 11 region region NN cord-267475-6f4h3cck 341 12 between between IN cord-267475-6f4h3cck 341 13 the the DT cord-267475-6f4h3cck 341 14 end end NN cord-267475-6f4h3cck 341 15 of of IN cord-267475-6f4h3cck 341 16 ORF1 ORF1 NNP cord-267475-6f4h3cck 341 17 and and CC cord-267475-6f4h3cck 341 18 the the DT cord-267475-6f4h3cck 341 19 start start NN cord-267475-6f4h3cck 341 20 of of IN cord-267475-6f4h3cck 341 21 ORF3 ORF3 NNP cord-267475-6f4h3cck 341 22 is be VBZ cord-267475-6f4h3cck 341 23 consistent consistent JJ cord-267475-6f4h3cck 341 24 with with IN cord-267475-6f4h3cck 341 25 the the DT cord-267475-6f4h3cck 341 26 idea idea NN cord-267475-6f4h3cck 341 27 that that IN cord-267475-6f4h3cck 341 28 ORF3 ORF3 NNP cord-267475-6f4h3cck 341 29 might may MD cord-267475-6f4h3cck 341 30 be be VB cord-267475-6f4h3cck 341 31 translated translate VBN cord-267475-6f4h3cck 341 32 by by IN cord-267475-6f4h3cck 341 33 reinitiation reinitiation NN cord-267475-6f4h3cck 341 34 . . . cord-267475-6f4h3cck 342 1 Some some DT cord-267475-6f4h3cck 342 2 ribosomes ribosome NNS cord-267475-6f4h3cck 342 3 would would MD cord-267475-6f4h3cck 342 4 be be VB cord-267475-6f4h3cck 342 5 expected expect VBN cord-267475-6f4h3cck 342 6 to to TO cord-267475-6f4h3cck 342 7 translate translate VB cord-267475-6f4h3cck 342 8 p17 p17 NN cord-267475-6f4h3cck 342 9 ( ( -LRB- cord-267475-6f4h3cck 342 10 ORF2 ORF2 NNP cord-267475-6f4h3cck 342 11 ) ) -RRB- cord-267475-6f4h3cck 342 12 by by IN cord-267475-6f4h3cck 342 13 leaky leaky JJ cord-267475-6f4h3cck 342 14 scanning scanning NN cord-267475-6f4h3cck 342 15 , , , cord-267475-6f4h3cck 342 16 engendered engender VBN cord-267475-6f4h3cck 342 17 by by IN cord-267475-6f4h3cck 342 18 the the DT cord-267475-6f4h3cck 342 19 poor poor JJ cord-267475-6f4h3cck 342 20 context context NN cord-267475-6f4h3cck 342 21 at at IN cord-267475-6f4h3cck 342 22 the the DT cord-267475-6f4h3cck 342 23 start start NN cord-267475-6f4h3cck 342 24 of of IN cord-267475-6f4h3cck 342 25 ORF1 ORF1 NNP cord-267475-6f4h3cck 342 26 . . . cord-267475-6f4h3cck 343 1 Improving improve VBG cord-267475-6f4h3cck 343 2 the the DT cord-267475-6f4h3cck 343 3 context context NN cord-267475-6f4h3cck 343 4 at at IN cord-267475-6f4h3cck 343 5 the the DT cord-267475-6f4h3cck 343 6 start start NN cord-267475-6f4h3cck 343 7 of of IN cord-267475-6f4h3cck 343 8 ORF1 ORF1 NNP cord-267475-6f4h3cck 343 9 indeed indeed RB cord-267475-6f4h3cck 343 10 increased increase VBD cord-267475-6f4h3cck 343 11 production production NN cord-267475-6f4h3cck 343 12 of of IN cord-267475-6f4h3cck 343 13 p10 p10 NN cord-267475-6f4h3cck 343 14 ( ( -LRB- cord-267475-6f4h3cck 343 15 Shmulevitz Shmulevitz NNP cord-267475-6f4h3cck 343 16 et et NNP cord-267475-6f4h3cck 343 17 al al NNP cord-267475-6f4h3cck 343 18 . . NNP cord-267475-6f4h3cck 343 19 , , , cord-267475-6f4h3cck 343 20 2002 2002 CD cord-267475-6f4h3cck 343 21 ) ) -RRB- cord-267475-6f4h3cck 343 22 ; ; : cord-267475-6f4h3cck 343 23 unfortunately unfortunately RB cord-267475-6f4h3cck 343 24 , , , cord-267475-6f4h3cck 343 25 the the DT cord-267475-6f4h3cck 343 26 yield yield NN cord-267475-6f4h3cck 343 27 of of IN cord-267475-6f4h3cck 343 28 p17 p17 NN cord-267475-6f4h3cck 343 29 , , , cord-267475-6f4h3cck 343 30 which which WDT cord-267475-6f4h3cck 343 31 would would MD cord-267475-6f4h3cck 343 32 be be VB cord-267475-6f4h3cck 343 33 expected expect VBN cord-267475-6f4h3cck 343 34 to to TO cord-267475-6f4h3cck 343 35 decrease decrease VB cord-267475-6f4h3cck 343 36 , , , cord-267475-6f4h3cck 343 37 was be VBD cord-267475-6f4h3cck 343 38 not not RB cord-267475-6f4h3cck 343 39 monitored monitor VBN cord-267475-6f4h3cck 343 40 . . . cord-267475-6f4h3cck 344 1 The the DT cord-267475-6f4h3cck 344 2 observation observation NN cord-267475-6f4h3cck 344 3 that that IN cord-267475-6f4h3cck 344 4 strengthening strengthen VBG cord-267475-6f4h3cck 344 5 the the DT cord-267475-6f4h3cck 344 6 context context NN cord-267475-6f4h3cck 344 7 at at IN cord-267475-6f4h3cck 344 8 the the DT cord-267475-6f4h3cck 344 9 start start NN cord-267475-6f4h3cck 344 10 of of IN cord-267475-6f4h3cck 344 11 ORF1 ORF1 NNP cord-267475-6f4h3cck 344 12 had have VBD cord-267475-6f4h3cck 344 13 no no DT cord-267475-6f4h3cck 344 14 effect effect NN cord-267475-6f4h3cck 344 15 on on IN cord-267475-6f4h3cck 344 16 the the DT cord-267475-6f4h3cck 344 17 yield yield NN cord-267475-6f4h3cck 344 18 of of IN cord-267475-6f4h3cck 344 19 sC sC NNP cord-267475-6f4h3cck 344 20 is be VBZ cord-267475-6f4h3cck 344 21 not not RB cord-267475-6f4h3cck 344 22 surprising surprising JJ cord-267475-6f4h3cck 344 23 because because IN cord-267475-6f4h3cck 344 24 the the DT cord-267475-6f4h3cck 344 25 reinitiation reinitiation NN cord-267475-6f4h3cck 344 26 mechanism mechanism NN cord-267475-6f4h3cck 344 27 postulated postulate VBN cord-267475-6f4h3cck 344 28 to to IN cord-267475-6f4h3cck 344 29 underlie underlie VB cord-267475-6f4h3cck 344 30 translation translation NN cord-267475-6f4h3cck 344 31 of of IN cord-267475-6f4h3cck 344 32 ORF3 ORF3 NNP cord-267475-6f4h3cck 344 33 would would MD cord-267475-6f4h3cck 344 34 probably probably RB cord-267475-6f4h3cck 344 35 be be VB cord-267475-6f4h3cck 344 36 limited limit VBN cord-267475-6f4h3cck 344 37 by by IN cord-267475-6f4h3cck 344 38 other other JJ cord-267475-6f4h3cck 344 39 features feature NNS cord-267475-6f4h3cck 344 40 , , , cord-267475-6f4h3cck 344 41 such such JJ cord-267475-6f4h3cck 344 42 as as IN cord-267475-6f4h3cck 344 43 the the DT cord-267475-6f4h3cck 344 44 relatively relatively RB cord-267475-6f4h3cck 344 45 large large JJ cord-267475-6f4h3cck 344 46 size size NN cord-267475-6f4h3cck 344 47 of of IN cord-267475-6f4h3cck 344 48 ORF1 ORF1 NNP cord-267475-6f4h3cck 344 49 . . . cord-267475-6f4h3cck 345 1 first first JJ cord-267475-6f4h3cck 345 2 AUG AUG NNP cord-267475-6f4h3cck 345 3 ( ( -LRB- cord-267475-6f4h3cck 345 4 Herzog Herzog NNP cord-267475-6f4h3cck 345 5 et et NNP cord-267475-6f4h3cck 345 6 al al NNP cord-267475-6f4h3cck 345 7 . . NNP cord-267475-6f4h3cck 345 8 , , , cord-267475-6f4h3cck 345 9 1995 1995 CD cord-267475-6f4h3cck 345 10 ; ; : cord-267475-6f4h3cck 345 11 Sivakumaran Sivakumaran NNP cord-267475-6f4h3cck 345 12 and and CC cord-267475-6f4h3cck 345 13 Hacker Hacker NNP cord-267475-6f4h3cck 345 14 , , , cord-267475-6f4h3cck 345 15 1998 1998 CD cord-267475-6f4h3cck 345 16 ) ) -RRB- cord-267475-6f4h3cck 345 17 . . . cord-267475-6f4h3cck 346 1 The the DT cord-267475-6f4h3cck 346 2 pregenomic pregenomic JJ cord-267475-6f4h3cck 346 3 mRNA mrna NN cord-267475-6f4h3cck 346 4 of of IN cord-267475-6f4h3cck 346 5 rice rice NNP cord-267475-6f4h3cck 346 6 tungro tungro NNP cord-267475-6f4h3cck 346 7 bacilliform bacilliform NNP cord-267475-6f4h3cck 346 8 virus virus NN cord-267475-6f4h3cck 346 9 ( ( -LRB- cord-267475-6f4h3cck 346 10 Fig Fig NNP cord-267475-6f4h3cck 346 11 . . . cord-267475-6f4h3cck 346 12 1C 1C NNP cord-267475-6f4h3cck 346 13 ) ) -RRB- cord-267475-6f4h3cck 346 14 provides provide VBZ cord-267475-6f4h3cck 346 15 the the DT cord-267475-6f4h3cck 346 16 most most RBS cord-267475-6f4h3cck 346 17 dramatic dramatic JJ cord-267475-6f4h3cck 346 18 illustration illustration NN cord-267475-6f4h3cck 346 19 of of IN cord-267475-6f4h3cck 346 20 these these DT cord-267475-6f4h3cck 346 21 points point NNS cord-267475-6f4h3cck 346 22 . . . cord-267475-6f4h3cck 347 1 Use use NN cord-267475-6f4h3cck 347 2 of of IN cord-267475-6f4h3cck 347 3 a a DT cord-267475-6f4h3cck 347 4 weak weak JJ cord-267475-6f4h3cck 347 5 ( ( -LRB- cord-267475-6f4h3cck 347 6 non non JJ cord-267475-6f4h3cck 347 7 - - JJ cord-267475-6f4h3cck 347 8 AUG AUG NNP cord-267475-6f4h3cck 347 9 ) ) -RRB- cord-267475-6f4h3cck 347 10 codon codon NN cord-267475-6f4h3cck 347 11 to to TO cord-267475-6f4h3cck 347 12 initiate initiate VB cord-267475-6f4h3cck 347 13 ORF1 ORF1 NNP cord-267475-6f4h3cck 347 14 and and CC cord-267475-6f4h3cck 347 15 an an DT cord-267475-6f4h3cck 347 16 unfavorable unfavorable JJ cord-267475-6f4h3cck 347 17 context context NN cord-267475-6f4h3cck 347 18 at at IN cord-267475-6f4h3cck 347 19 the the DT cord-267475-6f4h3cck 347 20 start start NN cord-267475-6f4h3cck 347 21 of of IN cord-267475-6f4h3cck 347 22 ORF2 ORF2 NNP cord-267475-6f4h3cck 347 23 ( ( -LRB- cord-267475-6f4h3cck 347 24 UACaugA UACaugA NNP cord-267475-6f4h3cck 347 25 ) ) -RRB- cord-267475-6f4h3cck 347 26 enables enable VBZ cord-267475-6f4h3cck 347 27 the the DT cord-267475-6f4h3cck 347 28 majority majority NN cord-267475-6f4h3cck 347 29 of of IN cord-267475-6f4h3cck 347 30 ribosomes ribosome NNS cord-267475-6f4h3cck 347 31 to to TO cord-267475-6f4h3cck 347 32 reach reach VB cord-267475-6f4h3cck 347 33 and and CC cord-267475-6f4h3cck 347 34 initiate initiate VB cord-267475-6f4h3cck 347 35 at at IN cord-267475-6f4h3cck 347 36 the the DT cord-267475-6f4h3cck 347 37 start start NN cord-267475-6f4h3cck 347 38 of of IN cord-267475-6f4h3cck 347 39 ORF3 ORF3 NNP cord-267475-6f4h3cck 347 40 . . . cord-267475-6f4h3cck 348 1 The the DT cord-267475-6f4h3cck 348 2 ORF3 ORF3 NNP cord-267475-6f4h3cck 348 3 polyprotein polyprotein NN cord-267475-6f4h3cck 348 4 is be VBZ cord-267475-6f4h3cck 348 5 thought think VBN cord-267475-6f4h3cck 348 6 to to TO cord-267475-6f4h3cck 348 7 be be VB cord-267475-6f4h3cck 348 8 a a DT cord-267475-6f4h3cck 348 9 precursor precursor NN cord-267475-6f4h3cck 348 10 from from IN cord-267475-6f4h3cck 348 11 which which WDT cord-267475-6f4h3cck 348 12 coat coat NN cord-267475-6f4h3cck 348 13 protein protein NN cord-267475-6f4h3cck 348 14 , , , cord-267475-6f4h3cck 348 15 protease protease NN cord-267475-6f4h3cck 348 16 and and CC cord-267475-6f4h3cck 348 17 reverse reverse NN cord-267475-6f4h3cck 348 18 transcriptase transcriptase NN cord-267475-6f4h3cck 348 19 are be VBP cord-267475-6f4h3cck 348 20 derived derive VBN cord-267475-6f4h3cck 348 21 by by IN cord-267475-6f4h3cck 348 22 proteolysis proteolysis NN cord-267475-6f4h3cck 348 23 . . . cord-267475-6f4h3cck 349 1 The the DT cord-267475-6f4h3cck 349 2 remarkable remarkable JJ cord-267475-6f4h3cck 349 3 absence absence NN cord-267475-6f4h3cck 349 4 of of IN cord-267475-6f4h3cck 349 5 AUG AUG NNP cord-267475-6f4h3cck 349 6 codons codon NNS cord-267475-6f4h3cck 349 7 from from IN cord-267475-6f4h3cck 349 8 the the DT cord-267475-6f4h3cck 349 9 long long JJ cord-267475-6f4h3cck 349 10 ( ( -LRB- cord-267475-6f4h3cck 349 11 563 563 CD cord-267475-6f4h3cck 349 12 nt nt NN cord-267475-6f4h3cck 349 13 ) ) -RRB- cord-267475-6f4h3cck 349 14 coding code VBG cord-267475-6f4h3cck 349 15 domain domain NN cord-267475-6f4h3cck 349 16 of of IN cord-267475-6f4h3cck 349 17 ORF1 ORF1 NNP cord-267475-6f4h3cck 349 18 and and CC cord-267475-6f4h3cck 349 19 the the DT cord-267475-6f4h3cck 349 20 presence presence NN cord-267475-6f4h3cck 349 21 of of IN cord-267475-6f4h3cck 349 22 but but CC cord-267475-6f4h3cck 349 23 one one CD cord-267475-6f4h3cck 349 24 weak weak JJ cord-267475-6f4h3cck 349 25 AUG AUG NNP cord-267475-6f4h3cck 349 26 codon codon NN cord-267475-6f4h3cck 349 27 within within IN cord-267475-6f4h3cck 349 28 ORF2 ORF2 NNP cord-267475-6f4h3cck 349 29 underscore underscore VBP cord-267475-6f4h3cck 349 30 how how WRB cord-267475-6f4h3cck 349 31 carefully carefully RB cord-267475-6f4h3cck 349 32 this this DT cord-267475-6f4h3cck 349 33 mRNA mrna NN cord-267475-6f4h3cck 349 34 is be VBZ cord-267475-6f4h3cck 349 35 constructed construct VBN cord-267475-6f4h3cck 349 36 to to TO cord-267475-6f4h3cck 349 37 support support VB cord-267475-6f4h3cck 349 38 translation translation NN cord-267475-6f4h3cck 349 39 via via IN cord-267475-6f4h3cck 349 40 scanning scanning NN cord-267475-6f4h3cck 349 41 . . . cord-267475-6f4h3cck 350 1 The the DT cord-267475-6f4h3cck 350 2 careful careful JJ cord-267475-6f4h3cck 350 3 construction construction NN cord-267475-6f4h3cck 350 4 includes include VBZ cord-267475-6f4h3cck 350 5 minimizing minimize VBG cord-267475-6f4h3cck 350 6 the the DT cord-267475-6f4h3cck 350 7 overlap overlap NN cord-267475-6f4h3cck 350 8 between between IN cord-267475-6f4h3cck 350 9 adjacent adjacent JJ cord-267475-6f4h3cck 350 10 cistrons cistron NNS cord-267475-6f4h3cck 350 11 . . . cord-267475-6f4h3cck 351 1 Without without IN cord-267475-6f4h3cck 351 2 that that DT cord-267475-6f4h3cck 351 3 precaution precaution NN cord-267475-6f4h3cck 351 4 , , , cord-267475-6f4h3cck 351 5 elongational elongational NNP cord-267475-6f4h3cck 351 6 occlusion occlusion NN cord-267475-6f4h3cck 351 7 might may MD cord-267475-6f4h3cck 351 8 work work VB cord-267475-6f4h3cck 351 9 against against IN cord-267475-6f4h3cck 351 10 utilization utilization NN cord-267475-6f4h3cck 351 11 of of IN cord-267475-6f4h3cck 351 12 a a DT cord-267475-6f4h3cck 351 13 far far RB cord-267475-6f4h3cck 351 14 downstream downstream JJ cord-267475-6f4h3cck 351 15 start start NN cord-267475-6f4h3cck 351 16 codon codon NN cord-267475-6f4h3cck 351 17 , , , cord-267475-6f4h3cck 351 18 as as IN cord-267475-6f4h3cck 351 19 documented document VBN cord-267475-6f4h3cck 351 20 in in IN cord-267475-6f4h3cck 351 21 other other JJ cord-267475-6f4h3cck 351 22 cases case NNS cord-267475-6f4h3cck 351 23 ( ( -LRB- cord-267475-6f4h3cck 351 24 Kozak Kozak NNP cord-267475-6f4h3cck 351 25 , , , cord-267475-6f4h3cck 351 26 1995 1995 CD cord-267475-6f4h3cck 351 27 ) ) -RRB- cord-267475-6f4h3cck 351 28 . . . cord-267475-6f4h3cck 352 1 The the DT cord-267475-6f4h3cck 352 2 avian avian JJ cord-267475-6f4h3cck 352 3 reovirus reovirus FW cord-267475-6f4h3cck 352 4 RNA RNA NNP cord-267475-6f4h3cck 352 5 diagrammed diagram VBN cord-267475-6f4h3cck 352 6 in in IN cord-267475-6f4h3cck 352 7 Fig Fig NNP cord-267475-6f4h3cck 352 8 . . . cord-267475-6f4h3cck 353 1 1D 1D NNP cord-267475-6f4h3cck 353 2 offers offer VBZ cord-267475-6f4h3cck 353 3 another another DT cord-267475-6f4h3cck 353 4 example example NN cord-267475-6f4h3cck 353 5 of of IN cord-267475-6f4h3cck 353 6 initiation initiation NN cord-267475-6f4h3cck 353 7 from from IN cord-267475-6f4h3cck 353 8 three three CD cord-267475-6f4h3cck 353 9 sites site NNS cord-267475-6f4h3cck 353 10 in in IN cord-267475-6f4h3cck 353 11 one one CD cord-267475-6f4h3cck 353 12 mRNA mrna NN cord-267475-6f4h3cck 353 13 . . . cord-267475-6f4h3cck 354 1 Additional additional JJ cord-267475-6f4h3cck 354 2 experiments experiment NNS cord-267475-6f4h3cck 354 3 are be VBP cord-267475-6f4h3cck 354 4 needed need VBN cord-267475-6f4h3cck 354 5 to to TO cord-267475-6f4h3cck 354 6 validate validate VB cord-267475-6f4h3cck 354 7 the the DT cord-267475-6f4h3cck 354 8 postulated postulate VBN cord-267475-6f4h3cck 354 9 mechanism mechanism NN cord-267475-6f4h3cck 354 10 . . . cord-267475-6f4h3cck 355 1 In in IN cord-267475-6f4h3cck 355 2 contrast contrast NN cord-267475-6f4h3cck 355 3 with with IN cord-267475-6f4h3cck 355 4 the the DT cord-267475-6f4h3cck 355 5 ' ' `` cord-267475-6f4h3cck 355 6 maximally maximally RB cord-267475-6f4h3cck 355 7 leaky leaky JJ cord-267475-6f4h3cck 355 8 ' ' '' cord-267475-6f4h3cck 355 9 mRNAs mRNAs '' cord-267475-6f4h3cck 355 10 in in IN cord-267475-6f4h3cck 355 11 Fig Fig NNP cord-267475-6f4h3cck 355 12 . . . cord-267475-6f4h3cck 356 1 1 1 LS cord-267475-6f4h3cck 356 2 , , , cord-267475-6f4h3cck 356 3 the the DT cord-267475-6f4h3cck 356 4 mRNAs mRNAs NNPS cord-267475-6f4h3cck 356 5 in in IN cord-267475-6f4h3cck 356 6 Fig Fig NNP cord-267475-6f4h3cck 356 7 . . . cord-267475-6f4h3cck 357 1 2 2 CD cord-267475-6f4h3cck 357 2 are be VBP cord-267475-6f4h3cck 357 3 minimally minimally RB cord-267475-6f4h3cck 357 4 leaky leaky JJ cord-267475-6f4h3cck 357 5 : : : cord-267475-6f4h3cck 357 6 only only RB cord-267475-6f4h3cck 357 7 a a DT cord-267475-6f4h3cck 357 8 small small JJ cord-267475-6f4h3cck 357 9 fraction fraction NN cord-267475-6f4h3cck 357 10 of of IN cord-267475-6f4h3cck 357 11 ribosomes ribosome NNS cord-267475-6f4h3cck 357 12 bypass bypass VBP cord-267475-6f4h3cck 357 13 the the DT cord-267475-6f4h3cck 357 14 first first JJ cord-267475-6f4h3cck 357 15 AUG AUG NNP cord-267475-6f4h3cck 357 16 codon codon NN cord-267475-6f4h3cck 357 17 and and CC cord-267475-6f4h3cck 357 18 initiate initiate VB cord-267475-6f4h3cck 357 19 downstream downstream RB cord-267475-6f4h3cck 357 20 . . . cord-267475-6f4h3cck 358 1 Here here RB cord-267475-6f4h3cck 358 2 the the DT cord-267475-6f4h3cck 358 3 leaky leaky JJ cord-267475-6f4h3cck 358 4 scanning scanning NN cord-267475-6f4h3cck 358 5 mechanism mechanism NN cord-267475-6f4h3cck 358 6 has have VBZ cord-267475-6f4h3cck 358 7 been be VBN cord-267475-6f4h3cck 358 8 pushed push VBN cord-267475-6f4h3cck 358 9 to to IN cord-267475-6f4h3cck 358 10 the the DT cord-267475-6f4h3cck 358 11 limits limit NNS cord-267475-6f4h3cck 358 12 in in IN cord-267475-6f4h3cck 358 13 the the DT cord-267475-6f4h3cck 358 14 sense sense NN cord-267475-6f4h3cck 358 15 that that IN cord-267475-6f4h3cck 358 16 there there EX cord-267475-6f4h3cck 358 17 is be VBZ cord-267475-6f4h3cck 358 18 ( ( -LRB- cord-267475-6f4h3cck 358 19 lowlevel lowlevel JJ cord-267475-6f4h3cck 358 20 ) ) -RRB- cord-267475-6f4h3cck 358 21 initiation initiation NN cord-267475-6f4h3cck 358 22 from from IN cord-267475-6f4h3cck 358 23 a a DT cord-267475-6f4h3cck 358 24 second second JJ cord-267475-6f4h3cck 358 25 site site NN cord-267475-6f4h3cck 358 26 despite despite IN cord-267475-6f4h3cck 358 27 the the DT cord-267475-6f4h3cck 358 28 presence presence NN cord-267475-6f4h3cck 358 29 of of IN cord-267475-6f4h3cck 358 30 a a DT cord-267475-6f4h3cck 358 31 strong strong JJ cord-267475-6f4h3cck 358 32 context context NN cord-267475-6f4h3cck 358 33 around around IN cord-267475-6f4h3cck 358 34 the the DT cord-267475-6f4h3cck 358 35 first first JJ cord-267475-6f4h3cck 358 36 AUG AUG NNP cord-267475-6f4h3cck 358 37 codon codon NN cord-267475-6f4h3cck 358 38 . . . cord-267475-6f4h3cck 359 1 The the DT cord-267475-6f4h3cck 359 2 explanation explanation NN cord-267475-6f4h3cck 359 3 is be VBZ cord-267475-6f4h3cck 359 4 that that IN cord-267475-6f4h3cck 359 5 the the DT cord-267475-6f4h3cck 359 6 context context NN cord-267475-6f4h3cck 359 7 flanking flank VBG cord-267475-6f4h3cck 359 8 the the DT cord-267475-6f4h3cck 359 9 first first JJ cord-267475-6f4h3cck 359 10 AUG AUG NNP cord-267475-6f4h3cck 359 11 START START NNP cord-267475-6f4h3cck 359 12 codon codon NN cord-267475-6f4h3cck 359 13 is be VBZ cord-267475-6f4h3cck 359 14 good good JJ cord-267475-6f4h3cck 359 15 but but CC cord-267475-6f4h3cck 359 16 not not RB cord-267475-6f4h3cck 359 17 perfect perfect JJ cord-267475-6f4h3cck 359 18 . . . cord-267475-6f4h3cck 360 1 The the DT cord-267475-6f4h3cck 360 2 resulting result VBG cord-267475-6f4h3cck 360 3 low low JJ cord-267475-6f4h3cck 360 4 - - HYPH cord-267475-6f4h3cck 360 5 level level NN cord-267475-6f4h3cck 360 6 leaky leaky JJ cord-267475-6f4h3cck 360 7 scanning scanning NN cord-267475-6f4h3cck 360 8 enables enable VBZ cord-267475-6f4h3cck 360 9 the the DT cord-267475-6f4h3cck 360 10 viruses virus NNS cord-267475-6f4h3cck 360 11 depicted depict VBN cord-267475-6f4h3cck 360 12 in in IN cord-267475-6f4h3cck 360 13 Fig Fig NNP cord-267475-6f4h3cck 360 14 . . . cord-267475-6f4h3cck 361 1 2A 2A NNP cord-267475-6f4h3cck 361 2 , , , cord-267475-6f4h3cck 361 3 B b NN cord-267475-6f4h3cck 362 1 to to TO cord-267475-6f4h3cck 362 2 produce produce VB cord-267475-6f4h3cck 362 3 two two CD cord-267475-6f4h3cck 362 4 proteins protein NNS cord-267475-6f4h3cck 362 5 -one -one CD cord-267475-6f4h3cck 362 6 abundant abundant JJ cord-267475-6f4h3cck 362 7 , , , cord-267475-6f4h3cck 362 8 the the DT cord-267475-6f4h3cck 362 9 second second JJ cord-267475-6f4h3cck 362 10 in in IN cord-267475-6f4h3cck 362 11 small small JJ cord-267475-6f4h3cck 362 12 amountsfrom amountsfrom NN cord-267475-6f4h3cck 362 13 a a DT cord-267475-6f4h3cck 362 14 single single JJ cord-267475-6f4h3cck 362 15 mRNA mrna NN cord-267475-6f4h3cck 362 16 . . . cord-267475-6f4h3cck 363 1 Experimental experimental JJ cord-267475-6f4h3cck 363 2 manipulations manipulation NNS cord-267475-6f4h3cck 363 3 that that WDT cord-267475-6f4h3cck 363 4 support support VBP cord-267475-6f4h3cck 363 5 this this DT cord-267475-6f4h3cck 363 6 interpretation interpretation NN cord-267475-6f4h3cck 363 7 are be VBP cord-267475-6f4h3cck 363 8 summarized summarize VBN cord-267475-6f4h3cck 363 9 in in IN cord-267475-6f4h3cck 363 10 the the DT cord-267475-6f4h3cck 363 11 legend legend NN cord-267475-6f4h3cck 363 12 to to IN cord-267475-6f4h3cck 363 13 Fig Fig NNP cord-267475-6f4h3cck 363 14 . . . cord-267475-6f4h3cck 364 1 2 2 LS cord-267475-6f4h3cck 364 2 . . . cord-267475-6f4h3cck 365 1 A a DT cord-267475-6f4h3cck 365 2 few few JJ cord-267475-6f4h3cck 365 3 other other JJ cord-267475-6f4h3cck 365 4 viral viral JJ cord-267475-6f4h3cck 365 5 genes gene NNS cord-267475-6f4h3cck 365 6 that that WDT cord-267475-6f4h3cck 365 7 might may MD cord-267475-6f4h3cck 365 8 fit fit VB cord-267475-6f4h3cck 365 9 this this DT cord-267475-6f4h3cck 365 10 category category NN cord-267475-6f4h3cck 365 11 have have VBP cord-267475-6f4h3cck 365 12 been be VBN cord-267475-6f4h3cck 365 13 described describe VBN cord-267475-6f4h3cck 366 1 ( ( -LRB- cord-267475-6f4h3cck 366 2 Chenik Chenik NNP cord-267475-6f4h3cck 366 3 et et FW cord-267475-6f4h3cck 366 4 al al NNP cord-267475-6f4h3cck 366 5 . . . cord-267475-6f4h3cck 367 1 , , , cord-267475-6f4h3cck 367 2 1995 1995 CD cord-267475-6f4h3cck 367 3 ; ; : cord-267475-6f4h3cck 367 4 Jayakar Jayakar NNP cord-267475-6f4h3cck 367 5 and and CC cord-267475-6f4h3cck 367 6 Whitt Whitt NNP cord-267475-6f4h3cck 367 7 , , , cord-267475-6f4h3cck 367 8 2002 2002 CD cord-267475-6f4h3cck 367 9 ) ) -RRB- cord-267475-6f4h3cck 367 10 . . . cord-267475-6f4h3cck 368 1 The the DT cord-267475-6f4h3cck 368 2 hepatitis hepatitis NN cord-267475-6f4h3cck 368 3 B B NNP cord-267475-6f4h3cck 368 4 virus virus NN cord-267475-6f4h3cck 368 5 example example NN cord-267475-6f4h3cck 368 6 is be VBZ cord-267475-6f4h3cck 368 7 noteworthy noteworthy JJ cord-267475-6f4h3cck 368 8 because because IN cord-267475-6f4h3cck 368 9 , , , cord-267475-6f4h3cck 368 10 via via IN cord-267475-6f4h3cck 368 11 the the DT cord-267475-6f4h3cck 368 12 Rube Rube NNP cord-267475-6f4h3cck 368 13 Goldberg Goldberg NNP cord-267475-6f4h3cck 368 14 mechanism mechanism NN cord-267475-6f4h3cck 368 15 diagrammed diagram VBN cord-267475-6f4h3cck 368 16 in in IN cord-267475-6f4h3cck 368 17 Fig Fig NNP cord-267475-6f4h3cck 368 18 . . . cord-267475-6f4h3cck 368 19 2B 2b CD cord-267475-6f4h3cck 368 20 , , , cord-267475-6f4h3cck 368 21 reverse reverse JJ cord-267475-6f4h3cck 368 22 transcriptase transcriptase NN cord-267475-6f4h3cck 368 23 encoded encode VBN cord-267475-6f4h3cck 368 24 by by IN cord-267475-6f4h3cck 368 25 the the DT cord-267475-6f4h3cck 368 26 P p NN cord-267475-6f4h3cck 368 27 gene gene NN cord-267475-6f4h3cck 368 28 is be VBZ cord-267475-6f4h3cck 368 29 initiated initiate VBN cord-267475-6f4h3cck 368 30 independently independently RB cord-267475-6f4h3cck 368 31 from from IN cord-267475-6f4h3cck 368 32 a a DT cord-267475-6f4h3cck 368 33 far far RB cord-267475-6f4h3cck 368 34 downstream downstream JJ cord-267475-6f4h3cck 368 35 site site NN cord-267475-6f4h3cck 368 36 , , , cord-267475-6f4h3cck 368 37 unlike unlike IN cord-267475-6f4h3cck 368 38 most most JJS cord-267475-6f4h3cck 368 39 other other JJ cord-267475-6f4h3cck 368 40 reverse reverse JJ cord-267475-6f4h3cck 368 41 transcriptase transcriptase NN cord-267475-6f4h3cck 368 42 genes gene NNS cord-267475-6f4h3cck 368 43 which which WDT cord-267475-6f4h3cck 368 44 lack lack VBP cord-267475-6f4h3cck 368 45 an an DT cord-267475-6f4h3cck 368 46 independent independent JJ cord-267475-6f4h3cck 368 47 start start NN cord-267475-6f4h3cck 368 48 codon codon NN cord-267475-6f4h3cck 368 49 and and CC cord-267475-6f4h3cck 368 50 therefore therefore RB cord-267475-6f4h3cck 368 51 require require VBP cord-267475-6f4h3cck 368 52 frameshifting frameshifte VBG cord-267475-6f4h3cck 368 53 during during IN cord-267475-6f4h3cck 368 54 translation translation NN cord-267475-6f4h3cck 368 55 of of IN cord-267475-6f4h3cck 368 56 the the DT cord-267475-6f4h3cck 368 57 preceding precede VBG cord-267475-6f4h3cck 368 58 core core NN cord-267475-6f4h3cck 368 59 gene gene NN cord-267475-6f4h3cck 368 60 . . . cord-267475-6f4h3cck 369 1 Production production NN cord-267475-6f4h3cck 369 2 of of IN cord-267475-6f4h3cck 369 3 a a DT cord-267475-6f4h3cck 369 4 second second JJ cord-267475-6f4h3cck 369 5 protein protein NN cord-267475-6f4h3cck 369 6 isoform isoform NN cord-267475-6f4h3cck 369 7 via via IN cord-267475-6f4h3cck 369 8 low low JJ cord-267475-6f4h3cck 369 9 - - HYPH cord-267475-6f4h3cck 369 10 level level NN cord-267475-6f4h3cck 369 11 leaky leaky JJ cord-267475-6f4h3cck 369 12 scanning scanning NN cord-267475-6f4h3cck 369 13 is be VBZ cord-267475-6f4h3cck 369 14 seen see VBN cord-267475-6f4h3cck 369 15 also also RB cord-267475-6f4h3cck 369 16 with with IN cord-267475-6f4h3cck 369 17 some some DT cord-267475-6f4h3cck 369 18 cellular cellular JJ cord-267475-6f4h3cck 369 19 mRNAs mrna NNS cord-267475-6f4h3cck 369 20 . . . cord-267475-6f4h3cck 370 1 An an DT cord-267475-6f4h3cck 370 2 interesting interesting JJ cord-267475-6f4h3cck 370 3 example example NN cord-267475-6f4h3cck 370 4 is be VBZ cord-267475-6f4h3cck 370 5 the the DT cord-267475-6f4h3cck 370 6 production production NN cord-267475-6f4h3cck 370 7 in in IN cord-267475-6f4h3cck 370 8 rats rat NNS cord-267475-6f4h3cck 370 9 of of IN cord-267475-6f4h3cck 370 10 an an DT cord-267475-6f4h3cck 370 11 osteogenic osteogenic JJ cord-267475-6f4h3cck 370 12 growth growth NN cord-267475-6f4h3cck 370 13 peptide peptide NN cord-267475-6f4h3cck 370 14 ( ( -LRB- cord-267475-6f4h3cck 370 15 OGP OGP NNP cord-267475-6f4h3cck 370 16 ) ) -RRB- cord-267475-6f4h3cck 370 17 initiated initiate VBD cord-267475-6f4h3cck 370 18 from from IN cord-267475-6f4h3cck 370 19 codon codon NNP cord-267475-6f4h3cck 370 20 85 85 CD cord-267475-6f4h3cck 370 21 in in IN cord-267475-6f4h3cck 370 22 the the DT cord-267475-6f4h3cck 370 23 histone histone NN cord-267475-6f4h3cck 370 24 H4 H4 NNP cord-267475-6f4h3cck 370 25 gene gene NN cord-267475-6f4h3cck 370 26 ( ( -LRB- cord-267475-6f4h3cck 370 27 Fig Fig NNP cord-267475-6f4h3cck 370 28 . . . cord-267475-6f4h3cck 370 29 2C 2C NNP cord-267475-6f4h3cck 370 30 ) ) -RRB- cord-267475-6f4h3cck 370 31 . . . cord-267475-6f4h3cck 371 1 The the DT cord-267475-6f4h3cck 371 2 leaky leaky JJ cord-267475-6f4h3cck 371 3 scanning scanning NN cord-267475-6f4h3cck 371 4 explanation explanation NN cord-267475-6f4h3cck 371 5 was be VBD cord-267475-6f4h3cck 371 6 tested test VBN cord-267475-6f4h3cck 371 7 by by IN cord-267475-6f4h3cck 371 8 showing show VBG cord-267475-6f4h3cck 371 9 that that DT cord-267475-6f4h3cck 371 10 production production NN cord-267475-6f4h3cck 371 11 of of IN cord-267475-6f4h3cck 371 12 OGP ogp NN cord-267475-6f4h3cck 371 13 increased increase VBD cord-267475-6f4h3cck 371 14 upon upon IN cord-267475-6f4h3cck 371 15 deleting delete VBG cord-267475-6f4h3cck 371 16 the the DT cord-267475-6f4h3cck 371 17 upstream upstream JJ cord-267475-6f4h3cck 371 18 H4 H4 NNP cord-267475-6f4h3cck 371 19 start start NN cord-267475-6f4h3cck 371 20 codon codon NN cord-267475-6f4h3cck 371 21 , , , cord-267475-6f4h3cck 371 22 and and CC cord-267475-6f4h3cck 371 23 that that IN cord-267475-6f4h3cck 371 24 production production NN cord-267475-6f4h3cck 371 25 of of IN cord-267475-6f4h3cck 371 26 OGP ogp NN cord-267475-6f4h3cck 371 27 was be VBD cord-267475-6f4h3cck 371 28 suppressed suppress VBN cord-267475-6f4h3cck 371 29 upon upon IN cord-267475-6f4h3cck 371 30 changing change VBG cord-267475-6f4h3cck 371 31 the the DT cord-267475-6f4h3cck 371 32 H4 H4 NNP cord-267475-6f4h3cck 371 33 start start NN cord-267475-6f4h3cck 371 34 codon codon NN cord-267475-6f4h3cck 371 35 from from IN cord-267475-6f4h3cck 371 36 a a DT cord-267475-6f4h3cck 371 37 good good NN cord-267475-6f4h3cck 371 38 ( ( -LRB- cord-267475-6f4h3cck 371 39 AGGAAGaugU AGGAAGaugU NNP cord-267475-6f4h3cck 371 40 ) ) -RRB- cord-267475-6f4h3cck 371 41 to to IN cord-267475-6f4h3cck 371 42 a a DT cord-267475-6f4h3cck 371 43 perfect perfect JJ cord-267475-6f4h3cck 371 44 ( ( -LRB- cord-267475-6f4h3cck 371 45 GCCACCaugG GCCACCaugG NNP cord-267475-6f4h3cck 371 46 ) ) -RRB- cord-267475-6f4h3cck 371 47 context context NN cord-267475-6f4h3cck 371 48 . . . cord-267475-6f4h3cck 372 1 A a DT cord-267475-6f4h3cck 372 2 similar similar JJ cord-267475-6f4h3cck 372 3 mechanism mechanism NN cord-267475-6f4h3cck 372 4 might may MD cord-267475-6f4h3cck 372 5 operate operate VB cord-267475-6f4h3cck 372 6 with with IN cord-267475-6f4h3cck 372 7 a a DT cord-267475-6f4h3cck 372 8 few few JJ cord-267475-6f4h3cck 372 9 other other JJ cord-267475-6f4h3cck 372 10 cellular cellular JJ cord-267475-6f4h3cck 372 11 genes gene NNS cord-267475-6f4h3cck 372 12 that that WDT cord-267475-6f4h3cck 372 13 produce produce VBP cord-267475-6f4h3cck 372 14 a a DT cord-267475-6f4h3cck 372 15 trace trace NN cord-267475-6f4h3cck 372 16 amount amount NN cord-267475-6f4h3cck 372 17 of of IN cord-267475-6f4h3cck 372 18 a a DT cord-267475-6f4h3cck 372 19 second second JJ cord-267475-6f4h3cck 372 20 protein protein NN cord-267475-6f4h3cck 372 21 isoform isoform NN cord-267475-6f4h3cck 372 22 Short Short NNP cord-267475-6f4h3cck 372 23 and and CC cord-267475-6f4h3cck 372 24 Pfarr Pfarr NNP cord-267475-6f4h3cck 372 25 , , , cord-267475-6f4h3cck 372 26 2002 2002 CD cord-267475-6f4h3cck 372 27 ; ; : cord-267475-6f4h3cck 372 28 _SP cord-267475-6f4h3cck 372 29 it -PRON- PRP cord-267475-6f4h3cck 372 30 is be VBZ cord-267475-6f4h3cck 372 31 not not RB cord-267475-6f4h3cck 372 32 clear clear JJ cord-267475-6f4h3cck 372 33 whether whether IN cord-267475-6f4h3cck 372 34 leaky leaky JJ cord-267475-6f4h3cck 372 35 scanning scanning NN cord-267475-6f4h3cck 372 36 or or CC cord-267475-6f4h3cck 372 37 a a DT cord-267475-6f4h3cck 372 38 change change NN cord-267475-6f4h3cck 372 39 in in IN cord-267475-6f4h3cck 372 40 splicing splicing NN cord-267475-6f4h3cck 372 41 underlies underlie VBZ cord-267475-6f4h3cck 372 42 the the DT cord-267475-6f4h3cck 372 43 translational translational JJ cord-267475-6f4h3cck 372 44 switch switch NN cord-267475-6f4h3cck 372 45 described describe VBN cord-267475-6f4h3cck 372 46 by by IN cord-267475-6f4h3cck 372 47 Land Land NNP cord-267475-6f4h3cck 372 48 and and CC cord-267475-6f4h3cck 372 49 Rouault Rouault NNP cord-267475-6f4h3cck 372 50 , , , cord-267475-6f4h3cck 372 51 1998 1998 CD cord-267475-6f4h3cck 372 52 ) ) -RRB- cord-267475-6f4h3cck 372 53 . . . cord-267475-6f4h3cck 373 1 The the DT cord-267475-6f4h3cck 373 2 fourth fourth JJ cord-267475-6f4h3cck 373 3 example example NN cord-267475-6f4h3cck 373 4 in in IN cord-267475-6f4h3cck 373 5 Fig Fig NNP cord-267475-6f4h3cck 373 6 . . NNP cord-267475-6f4h3cck 373 7 2 2 CD cord-267475-6f4h3cck 373 8 differs differ VBZ cord-267475-6f4h3cck 373 9 from from IN cord-267475-6f4h3cck 373 10 the the DT cord-267475-6f4h3cck 373 11 others other NNS cord-267475-6f4h3cck 373 12 in in IN cord-267475-6f4h3cck 373 13 that that DT cord-267475-6f4h3cck 373 14 a a DT cord-267475-6f4h3cck 373 15 good good JJ cord-267475-6f4h3cck 373 16 - - HYPH cord-267475-6f4h3cck 373 17 but but CC cord-267475-6f4h3cck 373 18 - - HYPH cord-267475-6f4h3cck 373 19 not not RB cord-267475-6f4h3cck 373 20 - - HYPH cord-267475-6f4h3cck 373 21 perfect perfect JJ cord-267475-6f4h3cck 373 22 context context NN cord-267475-6f4h3cck 373 23 at at IN cord-267475-6f4h3cck 373 24 the the DT cord-267475-6f4h3cck 373 25 first first JJ cord-267475-6f4h3cck 373 26 start start NN cord-267475-6f4h3cck 373 27 site site NN cord-267475-6f4h3cck 373 28 serves serve VBZ cord-267475-6f4h3cck 373 29 , , , cord-267475-6f4h3cck 373 30 not not RB cord-267475-6f4h3cck 373 31 to to TO cord-267475-6f4h3cck 373 32 enable enable VB cord-267475-6f4h3cck 373 33 production production NN cord-267475-6f4h3cck 373 34 of of IN cord-267475-6f4h3cck 373 35 two two CD cord-267475-6f4h3cck 373 36 proteins protein NNS cord-267475-6f4h3cck 373 37 , , , cord-267475-6f4h3cck 373 38 but but CC cord-267475-6f4h3cck 373 39 simply simply RB cord-267475-6f4h3cck 373 40 to to TO cord-267475-6f4h3cck 373 41 modulate modulate VB cord-267475-6f4h3cck 373 42 the the DT cord-267475-6f4h3cck 373 43 yield yield NN cord-267475-6f4h3cck 373 44 of of IN cord-267475-6f4h3cck 373 45 A a DT cord-267475-6f4h3cck 373 46 2A 2a CD cord-267475-6f4h3cck 373 47 -R -R : cord-267475-6f4h3cck 373 48 from from IN cord-267475-6f4h3cck 373 49 the the DT cord-267475-6f4h3cck 373 50 second second JJ cord-267475-6f4h3cck 373 51 AUG AUG NNP cord-267475-6f4h3cck 373 52 . . . cord-267475-6f4h3cck 374 1 Examination examination NN cord-267475-6f4h3cck 374 2 of of IN cord-267475-6f4h3cck 374 3 A a DT cord-267475-6f4h3cck 374 4 2A 2a CD cord-267475-6f4h3cck 374 5 -R -R NNS cord-267475-6f4h3cck 374 6 genes gene NNS cord-267475-6f4h3cck 374 7 from from IN cord-267475-6f4h3cck 374 8 various various JJ cord-267475-6f4h3cck 374 9 organisms organism NNS cord-267475-6f4h3cck 374 10 shows show VBZ cord-267475-6f4h3cck 374 11 conservation conservation NN cord-267475-6f4h3cck 374 12 of of IN cord-267475-6f4h3cck 374 13 the the DT cord-267475-6f4h3cck 374 14 overlapping overlapping JJ cord-267475-6f4h3cck 374 15 ORF ORF NNP cord-267475-6f4h3cck 374 16 , , , cord-267475-6f4h3cck 374 17 with with IN cord-267475-6f4h3cck 374 18 the the DT cord-267475-6f4h3cck 374 19 upstream upstream JJ cord-267475-6f4h3cck 374 20 AUG AUG NNP cord-267475-6f4h3cck 374 21 codon codon NN cord-267475-6f4h3cck 374 22 always always RB cord-267475-6f4h3cck 374 23 in in IN cord-267475-6f4h3cck 374 24 a a DT cord-267475-6f4h3cck 374 25 context context NN cord-267475-6f4h3cck 374 26 that that WDT cord-267475-6f4h3cck 374 27 allows allow VBZ cord-267475-6f4h3cck 374 28 only only RB cord-267475-6f4h3cck 374 29 low low JJ cord-267475-6f4h3cck 374 30 - - HYPH cord-267475-6f4h3cck 374 31 level level NN cord-267475-6f4h3cck 374 32 leaky leaky JJ cord-267475-6f4h3cck 374 33 scanning scanning NN cord-267475-6f4h3cck 374 34 ( ( -LRB- cord-267475-6f4h3cck 374 35 Lee Lee NNP cord-267475-6f4h3cck 374 36 et et NNP cord-267475-6f4h3cck 374 37 al al NNP cord-267475-6f4h3cck 374 38 . . NNP cord-267475-6f4h3cck 374 39 , , , cord-267475-6f4h3cck 374 40 1999 1999 CD cord-267475-6f4h3cck 374 41 ) ) -RRB- cord-267475-6f4h3cck 374 42 . . . cord-267475-6f4h3cck 375 1 Conservation conservation NN cord-267475-6f4h3cck 375 2 of of IN cord-267475-6f4h3cck 375 3 the the DT cord-267475-6f4h3cck 375 4 structure structure NN cord-267475-6f4h3cck 375 5 supports support VBZ cord-267475-6f4h3cck 375 6 the the DT cord-267475-6f4h3cck 375 7 interpretation interpretation NN cord-267475-6f4h3cck 375 8 that that IN cord-267475-6f4h3cck 375 9 this this DT cord-267475-6f4h3cck 375 10 is be VBZ cord-267475-6f4h3cck 375 11 a a DT cord-267475-6f4h3cck 375 12 device device NN cord-267475-6f4h3cck 375 13 contrived contrive VBN cord-267475-6f4h3cck 375 14 to to TO cord-267475-6f4h3cck 375 15 limit limit VB cord-267475-6f4h3cck 375 16 the the DT cord-267475-6f4h3cck 375 17 production production NN cord-267475-6f4h3cck 375 18 of of IN cord-267475-6f4h3cck 375 19 A a DT cord-267475-6f4h3cck 375 20 2A 2a CD cord-267475-6f4h3cck 375 21 -R -R NNP cord-267475-6f4h3cck 375 22 protein protein NN cord-267475-6f4h3cck 375 23 . . . cord-267475-6f4h3cck 376 1 Low low JJ cord-267475-6f4h3cck 376 2 - - HYPH cord-267475-6f4h3cck 376 3 level level NN cord-267475-6f4h3cck 376 4 leaky leaky JJ cord-267475-6f4h3cck 376 5 scanning scanning NN cord-267475-6f4h3cck 376 6 caused cause VBN cord-267475-6f4h3cck 376 7 by by IN cord-267475-6f4h3cck 376 8 a a DT cord-267475-6f4h3cck 376 9 not not RB cord-267475-6f4h3cck 376 10 - - HYPH cord-267475-6f4h3cck 376 11 quite quite RB cord-267475-6f4h3cck 376 12 - - HYPH cord-267475-6f4h3cck 376 13 perfect perfect JJ cord-267475-6f4h3cck 376 14 context context NN cord-267475-6f4h3cck 376 15 around around IN cord-267475-6f4h3cck 376 16 the the DT cord-267475-6f4h3cck 376 17 first first JJ cord-267475-6f4h3cck 376 18 AUG AUG NNP cord-267475-6f4h3cck 376 19 codon codon NN cord-267475-6f4h3cck 376 20 might may MD cord-267475-6f4h3cck 376 21 occur occur VB cord-267475-6f4h3cck 376 22 with with IN cord-267475-6f4h3cck 376 23 other other JJ cord-267475-6f4h3cck 376 24 mRNAs mrna NNS cord-267475-6f4h3cck 376 25 where where WRB cord-267475-6f4h3cck 376 26 it -PRON- PRP cord-267475-6f4h3cck 376 27 normally normally RB cord-267475-6f4h3cck 376 28 goes go VBZ cord-267475-6f4h3cck 376 29 unnoticed unnoticed JJ cord-267475-6f4h3cck 376 30 because because IN cord-267475-6f4h3cck 376 31 the the DT cord-267475-6f4h3cck 376 32 downstream downstream JJ cord-267475-6f4h3cck 376 33 start start NN cord-267475-6f4h3cck 376 34 site(s site(s RB cord-267475-6f4h3cck 376 35 ) ) -RRB- cord-267475-6f4h3cck 376 36 are be VBP cord-267475-6f4h3cck 376 37 out out RB cord-267475-6f4h3cck 376 38 - - HYPH cord-267475-6f4h3cck 376 39 of of IN cord-267475-6f4h3cck 376 40 - - HYPH cord-267475-6f4h3cck 376 41 frame frame NN cord-267475-6f4h3cck 376 42 . . . cord-267475-6f4h3cck 377 1 Antigenic antigenic JJ cord-267475-6f4h3cck 377 2 peptides peptide NNS cord-267475-6f4h3cck 377 3 recognized recognize VBN cord-267475-6f4h3cck 377 4 by by IN cord-267475-6f4h3cck 377 5 cytotoxic cytotoxic JJ cord-267475-6f4h3cck 377 6 T t NN cord-267475-6f4h3cck 377 7 - - HYPH cord-267475-6f4h3cck 377 8 lymphocytes lymphocyte NNS cord-267475-6f4h3cck 377 9 ( ( -LRB- cord-267475-6f4h3cck 377 10 CTLs CTLs NNP cord-267475-6f4h3cck 377 11 ) ) -RRB- cord-267475-6f4h3cck 377 12 might may MD cord-267475-6f4h3cck 377 13 be be VB cord-267475-6f4h3cck 377 14 produced produce VBN cord-267475-6f4h3cck 377 15 in in IN cord-267475-6f4h3cck 377 16 this this DT cord-267475-6f4h3cck 377 17 way way NN cord-267475-6f4h3cck 377 18 , , , cord-267475-6f4h3cck 377 19 as as IN cord-267475-6f4h3cck 377 20 discussed discuss VBN cord-267475-6f4h3cck 377 21 in in IN cord-267475-6f4h3cck 377 22 Section section NN cord-267475-6f4h3cck 377 23 5.4 5.4 CD cord-267475-6f4h3cck 377 24 . . . cord-267475-6f4h3cck 378 1 A a DT cord-267475-6f4h3cck 378 2 small small JJ cord-267475-6f4h3cck 378 3 degree degree NN cord-267475-6f4h3cck 378 4 of of IN cord-267475-6f4h3cck 378 5 leaky leaky JJ cord-267475-6f4h3cck 378 6 scanning scanning NN cord-267475-6f4h3cck 378 7 that that WDT cord-267475-6f4h3cck 378 8 normally normally RB cord-267475-6f4h3cck 378 9 goes go VBZ cord-267475-6f4h3cck 378 10 unnoticed unnoticed JJ cord-267475-6f4h3cck 378 11 could could MD cord-267475-6f4h3cck 378 12 become become VB cord-267475-6f4h3cck 378 13 significant significant JJ cord-267475-6f4h3cck 378 14 if if IN cord-267475-6f4h3cck 378 15 a a DT cord-267475-6f4h3cck 378 16 mutation mutation NN cord-267475-6f4h3cck 378 17 that that WDT cord-267475-6f4h3cck 378 18 shifts shift VBZ cord-267475-6f4h3cck 378 19 the the DT cord-267475-6f4h3cck 378 20 normal normal JJ cord-267475-6f4h3cck 378 21 start start NN cord-267475-6f4h3cck 378 22 codon codon NN cord-267475-6f4h3cck 378 23 out out IN cord-267475-6f4h3cck 378 24 of of IN cord-267475-6f4h3cck 378 25 frame frame NN cord-267475-6f4h3cck 378 26 moves move VBZ cord-267475-6f4h3cck 378 27 a a DT cord-267475-6f4h3cck 378 28 downstream downstream JJ cord-267475-6f4h3cck 378 29 AUG AUG NNP cord-267475-6f4h3cck 378 30 codon codon NN cord-267475-6f4h3cck 378 31 into into IN cord-267475-6f4h3cck 378 32 the the DT cord-267475-6f4h3cck 378 33 main main JJ cord-267475-6f4h3cck 378 34 reading reading NN cord-267475-6f4h3cck 378 35 frame frame NN cord-267475-6f4h3cck 378 36 . . . cord-267475-6f4h3cck 379 1 In in IN cord-267475-6f4h3cck 379 2 some some DT cord-267475-6f4h3cck 379 3 cases case NNS cord-267475-6f4h3cck 379 4 where where WRB cord-267475-6f4h3cck 379 5 low low JJ cord-267475-6f4h3cck 379 6 - - HYPH cord-267475-6f4h3cck 379 7 level level NN cord-267475-6f4h3cck 379 8 internal internal JJ cord-267475-6f4h3cck 379 9 initiation initiation NN cord-267475-6f4h3cck 379 10 was be VBD cord-267475-6f4h3cck 379 11 observed observe VBN cord-267475-6f4h3cck 379 12 with with IN cord-267475-6f4h3cck 379 13 such such PDT cord-267475-6f4h3cck 379 14 a a DT cord-267475-6f4h3cck 379 15 mutated mutate VBN cord-267475-6f4h3cck 379 16 gene gene NN cord-267475-6f4h3cck 379 17 ( ( -LRB- cord-267475-6f4h3cck 379 18 e.g. e.g. IN cord-267475-6f4h3cck 379 19 Maser Maser NNP cord-267475-6f4h3cck 379 20 et et NNP cord-267475-6f4h3cck 379 21 al al NNP cord-267475-6f4h3cck 379 22 . . NNP cord-267475-6f4h3cck 379 23 , , , cord-267475-6f4h3cck 379 24 2001 2001 CD cord-267475-6f4h3cck 379 25 ) ) -RRB- cord-267475-6f4h3cck 379 26 , , , cord-267475-6f4h3cck 379 27 the the DT cord-267475-6f4h3cck 379 28 possibility possibility NN cord-267475-6f4h3cck 379 29 that that IN cord-267475-6f4h3cck 379 30 the the DT cord-267475-6f4h3cck 379 31 downstream downstream JJ cord-267475-6f4h3cck 379 32 site site NN cord-267475-6f4h3cck 379 33 is be VBZ cord-267475-6f4h3cck 379 34 reached reach VBN cord-267475-6f4h3cck 379 35 via via IN cord-267475-6f4h3cck 379 36 a a DT cord-267475-6f4h3cck 379 37 combination combination NN cord-267475-6f4h3cck 379 38 of of IN cord-267475-6f4h3cck 379 39 leaky leaky JJ cord-267475-6f4h3cck 379 40 scanning scanning NN cord-267475-6f4h3cck 379 41 and and CC cord-267475-6f4h3cck 379 42 reinitiation reinitiation NN cord-267475-6f4h3cck 379 43 -a -a HYPH cord-267475-6f4h3cck 379 44 mechanism mechanism NN cord-267475-6f4h3cck 379 45 such such JJ cord-267475-6f4h3cck 379 46 as as IN cord-267475-6f4h3cck 379 47 that that DT cord-267475-6f4h3cck 379 48 proposed propose VBN cord-267475-6f4h3cck 379 49 for for IN cord-267475-6f4h3cck 379 50 hepatitis hepatitis NNP cord-267475-6f4h3cck 379 51 B B NNP cord-267475-6f4h3cck 379 52 virus virus NN cord-267475-6f4h3cck 379 53 ( ( -LRB- cord-267475-6f4h3cck 379 54 Fig Fig NNP cord-267475-6f4h3cck 379 55 . . . cord-267475-6f4h3cck 379 56 2B 2b CD cord-267475-6f4h3cck 379 57 ) ) -RRB- cord-267475-6f4h3cck 380 1 -merits -merits JJ cord-267475-6f4h3cck 380 2 consideration consideration NN cord-267475-6f4h3cck 380 3 . . . cord-267475-6f4h3cck 381 1 Reinitiation reinitiation NN cord-267475-6f4h3cck 381 2 occurs occur VBZ cord-267475-6f4h3cck 381 3 with with IN cord-267475-6f4h3cck 381 4 mRNAs mRNAs NNPS cord-267475-6f4h3cck 381 5 , , , cord-267475-6f4h3cck 381 6 such such JJ cord-267475-6f4h3cck 381 7 as as IN cord-267475-6f4h3cck 381 8 those those DT cord-267475-6f4h3cck 381 9 depicted depict VBN cord-267475-6f4h3cck 381 10 in in IN cord-267475-6f4h3cck 381 11 Fig Fig NNP cord-267475-6f4h3cck 381 12 . . . cord-267475-6f4h3cck 382 1 3 3 LS cord-267475-6f4h3cck 382 2 , , , cord-267475-6f4h3cck 382 3 that that WDT cord-267475-6f4h3cck 382 4 have have VBP cord-267475-6f4h3cck 382 5 small small JJ cord-267475-6f4h3cck 382 6 ORFs orf NNS cord-267475-6f4h3cck 382 7 near near IN cord-267475-6f4h3cck 382 8 the the DT cord-267475-6f4h3cck 382 9 5 5 CD cord-267475-6f4h3cck 382 10 0 0 CD cord-267475-6f4h3cck 382 11 end end NN cord-267475-6f4h3cck 382 12 . . . cord-267475-6f4h3cck 383 1 Our -PRON- PRP$ cord-267475-6f4h3cck 383 2 rudimentary rudimentary JJ cord-267475-6f4h3cck 383 3 understanding understanding NN cord-267475-6f4h3cck 383 4 of of IN cord-267475-6f4h3cck 383 5 what what WP cord-267475-6f4h3cck 383 6 happens happen VBZ cord-267475-6f4h3cck 383 7 following follow VBG cord-267475-6f4h3cck 383 8 translation translation NN cord-267475-6f4h3cck 383 9 of of IN cord-267475-6f4h3cck 383 10 the the DT cord-267475-6f4h3cck 383 11 first first JJ cord-267475-6f4h3cck 383 12 upORF uporf NN cord-267475-6f4h3cck 383 13 may may MD cord-267475-6f4h3cck 383 14 be be VB cord-267475-6f4h3cck 383 15 summarized summarize VBN cord-267475-6f4h3cck 383 16 as as IN cord-267475-6f4h3cck 383 17 follows follow VBZ cord-267475-6f4h3cck 383 18 . . . cord-267475-6f4h3cck 384 1 When when WRB cord-267475-6f4h3cck 384 2 the the DT cord-267475-6f4h3cck 384 3 80S 80s CD cord-267475-6f4h3cck 384 4 ribosome ribosome NN cord-267475-6f4h3cck 384 5 reaches reach VBZ cord-267475-6f4h3cck 384 6 the the DT cord-267475-6f4h3cck 384 7 termination termination NN cord-267475-6f4h3cck 384 8 site site NN cord-267475-6f4h3cck 384 9 of of IN cord-267475-6f4h3cck 384 10 the the DT cord-267475-6f4h3cck 384 11 upORF uporf JJ cord-267475-6f4h3cck 384 12 , , , cord-267475-6f4h3cck 384 13 the the DT cord-267475-6f4h3cck 384 14 60S 60s CD cord-267475-6f4h3cck 384 15 ribosomal ribosomal JJ cord-267475-6f4h3cck 384 16 subunit subunit NN cord-267475-6f4h3cck 384 17 is be VBZ cord-267475-6f4h3cck 384 18 thought think VBN cord-267475-6f4h3cck 384 19 to to TO cord-267475-6f4h3cck 384 20 be be VB cord-267475-6f4h3cck 384 21 released release VBN cord-267475-6f4h3cck 384 22 ( ( -LRB- cord-267475-6f4h3cck 384 23 this this DT cord-267475-6f4h3cck 384 24 has have VBZ cord-267475-6f4h3cck 384 25 not not RB cord-267475-6f4h3cck 384 26 actually actually RB cord-267475-6f4h3cck 384 27 been be VBN cord-267475-6f4h3cck 384 28 shown show VBN cord-267475-6f4h3cck 384 29 ) ) -RRB- cord-267475-6f4h3cck 384 30 while while IN cord-267475-6f4h3cck 384 31 the the DT cord-267475-6f4h3cck 384 32 40S 40s CD cord-267475-6f4h3cck 384 33 subunit subunit NN cord-267475-6f4h3cck 384 34 remains remain VBZ cord-267475-6f4h3cck 384 35 bound bind VBN cord-267475-6f4h3cck 384 36 to to IN cord-267475-6f4h3cck 384 37 the the DT cord-267475-6f4h3cck 384 38 mRNA mrna NN cord-267475-6f4h3cck 384 39 , , , cord-267475-6f4h3cck 384 40 resumes resume VBZ cord-267475-6f4h3cck 384 41 scanning scanning NN cord-267475-6f4h3cck 384 42 , , , cord-267475-6f4h3cck 384 43 and and CC cord-267475-6f4h3cck 384 44 may may MD cord-267475-6f4h3cck 384 45 initiate initiate VB cord-267475-6f4h3cck 384 46 another another DT cord-267475-6f4h3cck 384 47 round round NN cord-267475-6f4h3cck 384 48 of of IN cord-267475-6f4h3cck 384 49 translation translation NN cord-267475-6f4h3cck 384 50 at at IN cord-267475-6f4h3cck 384 51 a a DT cord-267475-6f4h3cck 384 52 downstream downstream JJ cord-267475-6f4h3cck 384 53 AUG AUG NNP cord-267475-6f4h3cck 384 54 codon codon NN cord-267475-6f4h3cck 384 55 . . . cord-267475-6f4h3cck 385 1 For for IN cord-267475-6f4h3cck 385 2 the the DT cord-267475-6f4h3cck 385 3 downstream downstream JJ cord-267475-6f4h3cck 385 4 reinitiation reinitiation NN cord-267475-6f4h3cck 385 5 event event NN cord-267475-6f4h3cck 385 6 to to TO cord-267475-6f4h3cck 385 7 occur occur VB cord-267475-6f4h3cck 385 8 , , , cord-267475-6f4h3cck 385 9 the the DT cord-267475-6f4h3cck 385 10 40S 40s CD cord-267475-6f4h3cck 385 11 subunit subunit NN cord-267475-6f4h3cck 385 12 must must MD cord-267475-6f4h3cck 385 13 reacquire reacquire VB cord-267475-6f4h3cck 386 1 Met Met NNP cord-267475-6f4h3cck 386 2 - - HYPH cord-267475-6f4h3cck 386 3 tRNA tRNA NNP cord-267475-6f4h3cck 386 4 i i NNP cord-267475-6f4h3cck 386 5 and and CC cord-267475-6f4h3cck 386 6 this this DT cord-267475-6f4h3cck 386 7 appears appear VBZ cord-267475-6f4h3cck 386 8 to to TO cord-267475-6f4h3cck 386 9 be be VB cord-267475-6f4h3cck 386 10 an an DT cord-267475-6f4h3cck 386 11 important important JJ cord-267475-6f4h3cck 386 12 point point NN cord-267475-6f4h3cck 386 13 of of IN cord-267475-6f4h3cck 386 14 control control NN cord-267475-6f4h3cck 386 15 . . . cord-267475-6f4h3cck 387 1 Reacquisition reacquisition NN cord-267475-6f4h3cck 387 2 of of IN cord-267475-6f4h3cck 388 1 Met Met NNP cord-267475-6f4h3cck 388 2 - - HYPH cord-267475-6f4h3cck 388 3 tRNA tRNA NNP cord-267475-6f4h3cck 388 4 i i PRP cord-267475-6f4h3cck 388 5 is be VBZ cord-267475-6f4h3cck 388 6 promoted promote VBN cord-267475-6f4h3cck 388 7 by by IN cord-267475-6f4h3cck 388 8 lengthening lengthen VBG cord-267475-6f4h3cck 388 9 the the DT cord-267475-6f4h3cck 388 10 intercistronic intercistronic JJ cord-267475-6f4h3cck 388 11 domain domain NN cord-267475-6f4h3cck 388 12 ( ( -LRB- cord-267475-6f4h3cck 388 13 Abastado Abastado NNP cord-267475-6f4h3cck 388 14 et et FW cord-267475-6f4h3cck 388 15 al al NNP cord-267475-6f4h3cck 388 16 . . . cord-267475-6f4h3cck 389 1 , , , cord-267475-6f4h3cck 389 2 1991 1991 CD cord-267475-6f4h3cck 389 3 ; ; : cord-267475-6f4h3cck 389 4 Kozak Kozak NNP cord-267475-6f4h3cck 389 5 , , , cord-267475-6f4h3cck 389 6 1987c 1987c CD cord-267475-6f4h3cck 389 7 ) ) -RRB- cord-267475-6f4h3cck 389 8 , , , cord-267475-6f4h3cck 389 9 which which WDT cord-267475-6f4h3cck 389 10 provides provide VBZ cord-267475-6f4h3cck 389 11 more more JJR cord-267475-6f4h3cck 389 12 time time NN cord-267475-6f4h3cck 389 13 for for IN cord-267475-6f4h3cck 390 1 Met Met NNP cord-267475-6f4h3cck 390 2 - - HYPH cord-267475-6f4h3cck 390 3 tRNA tRNA NNP cord-267475-6f4h3cck 390 4 i i PRP cord-267475-6f4h3cck 390 5 to to TO cord-267475-6f4h3cck 390 6 bind bind VB cord-267475-6f4h3cck 390 7 , , , cord-267475-6f4h3cck 390 8 or or CC cord-267475-6f4h3cck 390 9 by by IN cord-267475-6f4h3cck 390 10 increasing increase VBG cord-267475-6f4h3cck 390 11 the the DT cord-267475-6f4h3cck 390 12 concentration concentration NN cord-267475-6f4h3cck 390 13 of of IN cord-267475-6f4h3cck 391 1 eIF2 eIF2 NNP cord-267475-6f4h3cck 391 2 ( ( -LRB- cord-267475-6f4h3cck 391 3 Abastado Abastado NNP cord-267475-6f4h3cck 391 4 et et FW cord-267475-6f4h3cck 391 5 al al NNP cord-267475-6f4h3cck 391 6 . . NNP cord-267475-6f4h3cck 391 7 , , , cord-267475-6f4h3cck 391 8 1991 1991 CD cord-267475-6f4h3cck 391 9 ; ; : cord-267475-6f4h3cck 391 10 Hinnebusch Hinnebusch NNP cord-267475-6f4h3cck 391 11 , , , cord-267475-6f4h3cck 391 12 1997 1997 CD cord-267475-6f4h3cck 391 13 ) ) -RRB- cord-267475-6f4h3cck 391 14 . . . cord-267475-6f4h3cck 392 1 Genetic genetic JJ cord-267475-6f4h3cck 392 2 experiments experiment NNS cord-267475-6f4h3cck 392 3 also also RB cord-267475-6f4h3cck 392 4 implicate implicate VBP cord-267475-6f4h3cck 392 5 eIF3 eIF3 NNP cord-267475-6f4h3cck 392 6 in in IN cord-267475-6f4h3cck 392 7 the the DT cord-267475-6f4h3cck 392 8 Met Met NNP cord-267475-6f4h3cck 392 9 - - HYPH cord-267475-6f4h3cck 392 10 tRNA tRNA NNP cord-267475-6f4h3cck 393 1 i i PRP cord-267475-6f4h3cck 393 2 rebinding rebind VBG cord-267475-6f4h3cck 393 3 step step NN cord-267475-6f4h3cck 394 1 ( ( -LRB- cord-267475-6f4h3cck 394 2 Garcia Garcia NNP cord-267475-6f4h3cck 394 3 - - HYPH cord-267475-6f4h3cck 394 4 Barrio Barrio NNP cord-267475-6f4h3cck 394 5 et et NNP cord-267475-6f4h3cck 394 6 al al NNP cord-267475-6f4h3cck 394 7 . . NNP cord-267475-6f4h3cck 394 8 , , , cord-267475-6f4h3cck 394 9 1995 1995 CD cord-267475-6f4h3cck 394 10 ) ) -RRB- cord-267475-6f4h3cck 394 11 . . . cord-267475-6f4h3cck 395 1 Another another DT cord-267475-6f4h3cck 395 2 potential potential JJ cord-267475-6f4h3cck 395 3 point point NN cord-267475-6f4h3cck 395 4 of of IN cord-267475-6f4h3cck 395 5 control control NN cord-267475-6f4h3cck 395 6 is be VBZ cord-267475-6f4h3cck 395 7 at at IN cord-267475-6f4h3cck 395 8 the the DT cord-267475-6f4h3cck 395 9 termination termination NN cord-267475-6f4h3cck 395 10 site site NN cord-267475-6f4h3cck 395 11 of of IN cord-267475-6f4h3cck 395 12 the the DT cord-267475-6f4h3cck 395 13 upORF uporf JJ cord-267475-6f4h3cck 395 14 , , , cord-267475-6f4h3cck 395 15 where where WRB cord-267475-6f4h3cck 395 16 certain certain JJ cord-267475-6f4h3cck 395 17 features feature NNS cord-267475-6f4h3cck 395 18 -perhaps -perhaps WDT cord-267475-6f4h3cck 395 19 nearby nearby JJ cord-267475-6f4h3cck 395 20 secondary secondary JJ cord-267475-6f4h3cck 395 21 structure structure NN cord-267475-6f4h3cck 395 22 ( ( -LRB- cord-267475-6f4h3cck 395 23 Grant Grant NNP cord-267475-6f4h3cck 395 24 and and CC cord-267475-6f4h3cck 395 25 Hinnebusch Hinnebusch NNP cord-267475-6f4h3cck 395 26 , , , cord-267475-6f4h3cck 395 27 1994 1994 CD cord-267475-6f4h3cck 395 28 ; ; : cord-267475-6f4h3cck 395 29 Vilela Vilela NNP cord-267475-6f4h3cck 395 30 et et FW cord-267475-6f4h3cck 395 31 al al NNP cord-267475-6f4h3cck 395 32 . . NNP cord-267475-6f4h3cck 395 33 , , , cord-267475-6f4h3cck 395 34 1998 1998 CD cord-267475-6f4h3cck 395 35 ) ) -RRB- cord-267475-6f4h3cck 396 1 -might -might : cord-267475-6f4h3cck 396 2 prevent prevent VB cord-267475-6f4h3cck 396 3 the the DT cord-267475-6f4h3cck 396 4 resumption resumption NN cord-267475-6f4h3cck 396 5 of of IN cord-267475-6f4h3cck 396 6 scanning scanning NN cord-267475-6f4h3cck 396 7 or or CC cord-267475-6f4h3cck 396 8 , , , cord-267475-6f4h3cck 396 9 in in IN cord-267475-6f4h3cck 396 10 some some DT cord-267475-6f4h3cck 396 11 other other JJ cord-267475-6f4h3cck 396 12 way way NN cord-267475-6f4h3cck 396 13 , , , cord-267475-6f4h3cck 396 14 prevent prevent VB cord-267475-6f4h3cck 396 15 reinitiation reinitiation NN cord-267475-6f4h3cck 396 16 . . . cord-267475-6f4h3cck 397 1 This this DT cord-267475-6f4h3cck 397 2 brief brief JJ cord-267475-6f4h3cck 397 3 summary summary NN cord-267475-6f4h3cck 397 4 is be VBZ cord-267475-6f4h3cck 397 5 based base VBN cord-267475-6f4h3cck 397 6 on on IN cord-267475-6f4h3cck 397 7 studies study NNS cord-267475-6f4h3cck 397 8 carried carry VBN cord-267475-6f4h3cck 397 9 out out RP cord-267475-6f4h3cck 397 10 in in IN cord-267475-6f4h3cck 397 11 yeast yeast NN cord-267475-6f4h3cck 397 12 and and CC cord-267475-6f4h3cck 397 13 mammals mammal NNS cord-267475-6f4h3cck 397 14 . . . cord-267475-6f4h3cck 398 1 Some some DT cord-267475-6f4h3cck 398 2 studies study NNS cord-267475-6f4h3cck 398 3 of of IN cord-267475-6f4h3cck 398 4 reinitiation reinitiation NN cord-267475-6f4h3cck 398 5 in in IN cord-267475-6f4h3cck 398 6 plants plant NNS cord-267475-6f4h3cck 398 7 suggest suggest VBP cord-267475-6f4h3cck 398 8 that that IN cord-267475-6f4h3cck 398 9 the the DT cord-267475-6f4h3cck 398 10 intercistronic intercistronic JJ cord-267475-6f4h3cck 398 11 sequence sequence NN cord-267475-6f4h3cck 398 12 may may MD cord-267475-6f4h3cck 398 13 have have VB cord-267475-6f4h3cck 398 14 effects effect NNS cord-267475-6f4h3cck 398 15 beyond beyond IN cord-267475-6f4h3cck 398 16 simply simply RB cord-267475-6f4h3cck 398 17 providing provide VBG cord-267475-6f4h3cck 398 18 time time NN cord-267475-6f4h3cck 398 19 for for IN cord-267475-6f4h3cck 398 20 ribosomes ribosome NNS cord-267475-6f4h3cck 398 21 to to TO cord-267475-6f4h3cck 398 22 reacquire reacquire VB cord-267475-6f4h3cck 398 23 Met Met NNP cord-267475-6f4h3cck 398 24 - - HYPH cord-267475-6f4h3cck 398 25 tRNA tRNA NNP cord-267475-6f4h3cck 399 1 ( ( -LRB- cord-267475-6f4h3cck 399 2 Wang Wang NNP cord-267475-6f4h3cck 399 3 and and CC cord-267475-6f4h3cck 399 4 Wessler Wessler NNP cord-267475-6f4h3cck 399 5 , , , cord-267475-6f4h3cck 399 6 1998 1998 CD cord-267475-6f4h3cck 399 7 ) ) -RRB- cord-267475-6f4h3cck 399 8 . . . cord-267475-6f4h3cck 400 1 Some some DT cord-267475-6f4h3cck 400 2 results result NNS cord-267475-6f4h3cck 400 3 obtained obtain VBN cord-267475-6f4h3cck 400 4 in in IN cord-267475-6f4h3cck 400 5 early early JJ cord-267475-6f4h3cck 400 6 experiments experiment NNS cord-267475-6f4h3cck 400 7 with with IN cord-267475-6f4h3cck 400 8 mammalian mammalian JJ cord-267475-6f4h3cck 400 9 vectors vector NNS cord-267475-6f4h3cck 400 10 were be VBD cord-267475-6f4h3cck 400 11 interpreted interpret VBN cord-267475-6f4h3cck 400 12 as as IN cord-267475-6f4h3cck 400 13 evidence evidence NN cord-267475-6f4h3cck 400 14 that that IN cord-267475-6f4h3cck 400 15 ribosomes ribosome NNS cord-267475-6f4h3cck 400 16 can can MD cord-267475-6f4h3cck 400 17 scan scan VB cord-267475-6f4h3cck 400 18 backwards backwards RB cord-267475-6f4h3cck 400 19 and and CC cord-267475-6f4h3cck 400 20 thus thus RB cord-267475-6f4h3cck 400 21 reinitiate reinitiate VB cord-267475-6f4h3cck 400 22 at at IN cord-267475-6f4h3cck 400 23 an an DT cord-267475-6f4h3cck 400 24 AUG AUG NNP cord-267475-6f4h3cck 400 25 codon codon NN cord-267475-6f4h3cck 400 26 positioned position VBN cord-267475-6f4h3cck 400 27 upstream upstream RB cord-267475-6f4h3cck 400 28 from from IN cord-267475-6f4h3cck 400 29 the the DT cord-267475-6f4h3cck 400 30 termination termination NN cord-267475-6f4h3cck 400 31 site site NN cord-267475-6f4h3cck 400 32 ( ( -LRB- cord-267475-6f4h3cck 400 33 Peabody Peabody NNP cord-267475-6f4h3cck 400 34 et et NNP cord-267475-6f4h3cck 400 35 al al NNP cord-267475-6f4h3cck 400 36 . . NNP cord-267475-6f4h3cck 400 37 , , , cord-267475-6f4h3cck 400 38 1986 1986 CD cord-267475-6f4h3cck 400 39 ) ) -RRB- cord-267475-6f4h3cck 400 40 , , , cord-267475-6f4h3cck 400 41 but but CC cord-267475-6f4h3cck 400 42 recent recent JJ cord-267475-6f4h3cck 400 43 experiments experiment NNS cord-267475-6f4h3cck 400 44 contradict contradict VBP cord-267475-6f4h3cck 400 45 Fig Fig NNP cord-267475-6f4h3cck 400 46 . . NNP cord-267475-6f4h3cck 400 47 2 2 CD cord-267475-6f4h3cck 400 48 . . . cord-267475-6f4h3cck 401 1 Examples example NNS cord-267475-6f4h3cck 401 2 of of IN cord-267475-6f4h3cck 401 3 minimally minimally RB cord-267475-6f4h3cck 401 4 leaky leaky JJ cord-267475-6f4h3cck 401 5 scanning scanning NN cord-267475-6f4h3cck 401 6 in in IN cord-267475-6f4h3cck 401 7 which which WDT cord-267475-6f4h3cck 401 8 a a DT cord-267475-6f4h3cck 401 9 strong strong JJ cord-267475-6f4h3cck 401 10 , , , cord-267475-6f4h3cck 401 11 but but CC cord-267475-6f4h3cck 401 12 not not RB cord-267475-6f4h3cck 401 13 quite quite RB cord-267475-6f4h3cck 401 14 perfect perfect JJ cord-267475-6f4h3cck 401 15 , , , cord-267475-6f4h3cck 401 16 context context NN cord-267475-6f4h3cck 401 17 at at IN cord-267475-6f4h3cck 401 18 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 401 19 causes cause VBZ cord-267475-6f4h3cck 401 20 most most JJS cord-267475-6f4h3cck 401 21 ribosomes ribosome NNS cord-267475-6f4h3cck 401 22 to to TO cord-267475-6f4h3cck 401 23 initiate initiate VB cord-267475-6f4h3cck 401 24 there there RB cord-267475-6f4h3cck 401 25 while while IN cord-267475-6f4h3cck 401 26 allowing allow VBG cord-267475-6f4h3cck 401 27 a a DT cord-267475-6f4h3cck 401 28 low low JJ cord-267475-6f4h3cck 401 29 level level NN cord-267475-6f4h3cck 401 30 of of IN cord-267475-6f4h3cck 401 31 initiation initiation NN cord-267475-6f4h3cck 401 32 downstream downstream RB cord-267475-6f4h3cck 401 33 . . . cord-267475-6f4h3cck 402 1 With with IN cord-267475-6f4h3cck 402 2 the the DT cord-267475-6f4h3cck 402 3 depicted depict VBN cord-267475-6f4h3cck 402 4 viral viral JJ cord-267475-6f4h3cck 402 5 mRNAs mRNAs . cord-267475-6f4h3cck 403 1 ( ( -LRB- cord-267475-6f4h3cck 403 2 A A NNP cord-267475-6f4h3cck 403 3 , , , cord-267475-6f4h3cck 403 4 B B NNP cord-267475-6f4h3cck 403 5 ) ) -RRB- cord-267475-6f4h3cck 403 6 , , , cord-267475-6f4h3cck 403 7 the the DT cord-267475-6f4h3cck 403 8 predominant predominant JJ cord-267475-6f4h3cck 403 9 product product NN cord-267475-6f4h3cck 403 10 of of IN cord-267475-6f4h3cck 403 11 translation translation NN cord-267475-6f4h3cck 403 12 is be VBZ cord-267475-6f4h3cck 403 13 the the DT cord-267475-6f4h3cck 403 14 capsid capsid JJ cord-267475-6f4h3cck 403 15 protein protein NN cord-267475-6f4h3cck 403 16 initiated initiate VBN cord-267475-6f4h3cck 403 17 from from IN cord-267475-6f4h3cck 403 18 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 403 19 . . . cord-267475-6f4h3cck 404 1 Low low JJ cord-267475-6f4h3cck 404 2 - - HYPH cord-267475-6f4h3cck 404 3 level level NN cord-267475-6f4h3cck 404 4 leaky leaky JJ cord-267475-6f4h3cck 404 5 scanning scanning NN cord-267475-6f4h3cck 404 6 generates generate VBZ cord-267475-6f4h3cck 404 7 a a DT cord-267475-6f4h3cck 404 8 small small JJ cord-267475-6f4h3cck 404 9 but but CC cord-267475-6f4h3cck 404 10 adequate adequate JJ cord-267475-6f4h3cck 404 11 amount amount NN cord-267475-6f4h3cck 404 12 of of IN cord-267475-6f4h3cck 404 13 the the DT cord-267475-6f4h3cck 404 14 indicated indicate VBN cord-267475-6f4h3cck 404 15 second second JJ cord-267475-6f4h3cck 404 16 protein protein NN cord-267475-6f4h3cck 404 17 . . . cord-267475-6f4h3cck 405 1 With with IN cord-267475-6f4h3cck 405 2 bovine bovine JJ cord-267475-6f4h3cck 405 3 coronavirus coronavirus NN cord-267475-6f4h3cck 405 4 , , , cord-267475-6f4h3cck 405 5 a a DT cord-267475-6f4h3cck 405 6 mutation mutation NN cord-267475-6f4h3cck 405 7 in in IN cord-267475-6f4h3cck 405 8 position position NN cord-267475-6f4h3cck 405 9 þ4 þ4 NNP cord-267475-6f4h3cck 405 10 ( ( -LRB- cord-267475-6f4h3cck 405 11 U U NNP cord-267475-6f4h3cck 405 12 ! ! . cord-267475-6f4h3cck 405 13 G G NNP cord-267475-6f4h3cck 405 14 , , , cord-267475-6f4h3cck 405 15 indicated indicate VBN cord-267475-6f4h3cck 405 16 in in IN cord-267475-6f4h3cck 405 17 red red NN cord-267475-6f4h3cck 405 18 ) ) -RRB- cord-267475-6f4h3cck 406 1 flanking flank VBG cord-267475-6f4h3cck 406 2 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 406 3 strongly strongly RB cord-267475-6f4h3cck 406 4 reduced reduce VBD cord-267475-6f4h3cck 406 5 translation translation NN cord-267475-6f4h3cck 406 6 from from IN cord-267475-6f4h3cck 406 7 the the DT cord-267475-6f4h3cck 406 8 downstream downstream JJ cord-267475-6f4h3cck 406 9 site site NN cord-267475-6f4h3cck 406 10 ( ( -LRB- cord-267475-6f4h3cck 406 11 Senanayake Senanayake NNP cord-267475-6f4h3cck 406 12 and and CC cord-267475-6f4h3cck 406 13 Brian Brian NNP cord-267475-6f4h3cck 406 14 , , , cord-267475-6f4h3cck 406 15 1997 1997 CD cord-267475-6f4h3cck 406 16 ) ) -RRB- cord-267475-6f4h3cck 406 17 , , , cord-267475-6f4h3cck 406 18 supporting support VBG cord-267475-6f4h3cck 406 19 the the DT cord-267475-6f4h3cck 406 20 interpretation interpretation NN cord-267475-6f4h3cck 406 21 that that IN cord-267475-6f4h3cck 406 22 the the DT cord-267475-6f4h3cck 406 23 natural natural JJ cord-267475-6f4h3cck 406 24 mRNA mrna NN cord-267475-6f4h3cck 406 25 is be VBZ cord-267475-6f4h3cck 406 26 slightly slightly RB cord-267475-6f4h3cck 406 27 leaky leaky JJ cord-267475-6f4h3cck 406 28 because because IN cord-267475-6f4h3cck 406 29 the the DT cord-267475-6f4h3cck 406 30 context context NN cord-267475-6f4h3cck 406 31 flanking flank VBG cord-267475-6f4h3cck 406 32 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 406 33 is be VBZ cord-267475-6f4h3cck 406 34 not not RB cord-267475-6f4h3cck 406 35 a a DT cord-267475-6f4h3cck 406 36 perfect perfect JJ cord-267475-6f4h3cck 406 37 match match NN cord-267475-6f4h3cck 406 38 to to IN cord-267475-6f4h3cck 406 39 the the DT cord-267475-6f4h3cck 406 40 consensus consensus NN cord-267475-6f4h3cck 406 41 sequence sequence NN cord-267475-6f4h3cck 406 42 . . . cord-267475-6f4h3cck 407 1 With with IN cord-267475-6f4h3cck 407 2 hepatitis hepatitis NN cord-267475-6f4h3cck 407 3 B B NNP cord-267475-6f4h3cck 407 4 virus virus NN cord-267475-6f4h3cck 407 5 , , , cord-267475-6f4h3cck 407 6 ribosomes ribosome NNS cord-267475-6f4h3cck 407 7 en en IN cord-267475-6f4h3cck 407 8 route route NN cord-267475-6f4h3cck 407 9 to to IN cord-267475-6f4h3cck 407 10 the the DT cord-267475-6f4h3cck 407 11 P p NN cord-267475-6f4h3cck 407 12 start start NN cord-267475-6f4h3cck 407 13 site site NN cord-267475-6f4h3cck 408 1 ( ( -LRB- cord-267475-6f4h3cck 408 2 AUG#5 aug#5 NN cord-267475-6f4h3cck 408 3 ) ) -RRB- cord-267475-6f4h3cck 408 4 apparently apparently RB cord-267475-6f4h3cck 408 5 bypass bypass VBP cord-267475-6f4h3cck 408 6 the the DT cord-267475-6f4h3cck 408 7 weak weak JJ cord-267475-6f4h3cck 408 8 AUG#2 AUG#2 NNP cord-267475-6f4h3cck 408 9 by by IN cord-267475-6f4h3cck 408 10 leaky leaky JJ cord-267475-6f4h3cck 408 11 scanning scanning NN cord-267475-6f4h3cck 408 12 , , , cord-267475-6f4h3cck 408 13 while while IN cord-267475-6f4h3cck 408 14 translation translation NN cord-267475-6f4h3cck 408 15 of of IN cord-267475-6f4h3cck 408 16 the the DT cord-267475-6f4h3cck 408 17 small small JJ cord-267475-6f4h3cck 408 18 ORF ORF NNP cord-267475-6f4h3cck 408 19 initiated initiate VBD cord-267475-6f4h3cck 408 20 at at IN cord-267475-6f4h3cck 408 21 AUG#3 aug#3 RB cord-267475-6f4h3cck 408 22 enables enable VBZ cord-267475-6f4h3cck 408 23 some some DT cord-267475-6f4h3cck 408 24 ribosomes ribosome NNS cord-267475-6f4h3cck 408 25 to to TO cord-267475-6f4h3cck 408 26 miss miss VB cord-267475-6f4h3cck 408 27 the the DT cord-267475-6f4h3cck 408 28 inhibitory inhibitory NN cord-267475-6f4h3cck 408 29 AUG#4 aug#4 CD cord-267475-6f4h3cck 408 30 ( ( -LRB- cord-267475-6f4h3cck 408 31 inhibitory inhibitory JJ cord-267475-6f4h3cck 408 32 because because IN cord-267475-6f4h3cck 408 33 it -PRON- PRP cord-267475-6f4h3cck 408 34 resides reside VBZ cord-267475-6f4h3cck 408 35 in in IN cord-267475-6f4h3cck 408 36 a a DT cord-267475-6f4h3cck 408 37 strong strong JJ cord-267475-6f4h3cck 408 38 context context NN cord-267475-6f4h3cck 408 39 and and CC cord-267475-6f4h3cck 408 40 overlaps overlap VBZ cord-267475-6f4h3cck 408 41 the the DT cord-267475-6f4h3cck 408 42 P P NNP cord-267475-6f4h3cck 408 43 ORF ORF NNP cord-267475-6f4h3cck 408 44 ) ) -RRB- cord-267475-6f4h3cck 408 45 and and CC cord-267475-6f4h3cck 408 46 thus thus RB cord-267475-6f4h3cck 408 47 to to TO cord-267475-6f4h3cck 408 48 reach reach VB cord-267475-6f4h3cck 408 49 AUG#5 AUG#5 NNP cord-267475-6f4h3cck 408 50 . . . cord-267475-6f4h3cck 409 1 Whereas whereas IN cord-267475-6f4h3cck 409 2 the the DT cord-267475-6f4h3cck 409 3 core core NN cord-267475-6f4h3cck 409 4 protein protein NN cord-267475-6f4h3cck 409 5 start start NN cord-267475-6f4h3cck 409 6 codon codon NNP cord-267475-6f4h3cck 410 1 ( ( -LRB- cord-267475-6f4h3cck 410 2 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 410 3 ) ) -RRB- cord-267475-6f4h3cck 411 1 here here RB cord-267475-6f4h3cck 411 2 depicted depict VBN cord-267475-6f4h3cck 411 3 resides reside VBZ cord-267475-6f4h3cck 411 4 in in IN cord-267475-6f4h3cck 411 5 a a DT cord-267475-6f4h3cck 411 6 context context NN cord-267475-6f4h3cck 411 7 which which WDT cord-267475-6f4h3cck 411 8 allows allow VBZ cord-267475-6f4h3cck 411 9 a a DT cord-267475-6f4h3cck 411 10 low low JJ cord-267475-6f4h3cck 411 11 level level NN cord-267475-6f4h3cck 411 12 of of IN cord-267475-6f4h3cck 411 13 leaky leaky JJ cord-267475-6f4h3cck 411 14 scanning scanning NN cord-267475-6f4h3cck 411 15 , , , cord-267475-6f4h3cck 412 1 a a DT cord-267475-6f4h3cck 412 2 slightly slightly RB cord-267475-6f4h3cck 412 3 longer long JJR cord-267475-6f4h3cck 412 4 mRNA mrna NN cord-267475-6f4h3cck 412 5 which which WDT cord-267475-6f4h3cck 412 6 encodes encode VBZ cord-267475-6f4h3cck 412 7 the the DT cord-267475-6f4h3cck 412 8 pre pre JJ cord-267475-6f4h3cck 412 9 - - JJ cord-267475-6f4h3cck 412 10 core core JJ cord-267475-6f4h3cck 412 11 protein protein NN cord-267475-6f4h3cck 412 12 has have VBZ cord-267475-6f4h3cck 412 13 a a DT cord-267475-6f4h3cck 412 14 stronger strong JJR cord-267475-6f4h3cck 412 15 start start NN cord-267475-6f4h3cck 412 16 codon codon NN cord-267475-6f4h3cck 413 1 ( ( -LRB- cord-267475-6f4h3cck 413 2 A a DT cord-267475-6f4h3cck 413 3 in in IN cord-267475-6f4h3cck 413 4 position position NN cord-267475-6f4h3cck 413 5 23 23 CD cord-267475-6f4h3cck 413 6 ) ) -RRB- cord-267475-6f4h3cck 413 7 and and CC cord-267475-6f4h3cck 413 8 polymerase polymerase NN cord-267475-6f4h3cck 413 9 can can MD cord-267475-6f4h3cck 413 10 not not RB cord-267475-6f4h3cck 413 11 be be VB cord-267475-6f4h3cck 413 12 translated translate VBN cord-267475-6f4h3cck 413 13 from from IN cord-267475-6f4h3cck 413 14 that that DT cord-267475-6f4h3cck 413 15 form form NN cord-267475-6f4h3cck 413 16 of of IN cord-267475-6f4h3cck 413 17 mRNA mrna NN cord-267475-6f4h3cck 414 1 ( ( -LRB- cord-267475-6f4h3cck 414 2 Fouillot Fouillot NNP cord-267475-6f4h3cck 414 3 and and CC cord-267475-6f4h3cck 414 4 Rossignol Rossignol NNP cord-267475-6f4h3cck 414 5 , , , cord-267475-6f4h3cck 414 6 1996 1996 CD cord-267475-6f4h3cck 414 7 ) ) -RRB- cord-267475-6f4h3cck 414 8 . . . cord-267475-6f4h3cck 415 1 The the DT cord-267475-6f4h3cck 415 2 publications publication NNS cord-267475-6f4h3cck 415 3 on on IN cord-267475-6f4h3cck 415 4 which which WDT cord-267475-6f4h3cck 415 5 the the DT cord-267475-6f4h3cck 415 6 scheme scheme NN cord-267475-6f4h3cck 415 7 shown show VBN cord-267475-6f4h3cck 415 8 here here RB cord-267475-6f4h3cck 415 9 is be VBZ cord-267475-6f4h3cck 415 10 based base VBN cord-267475-6f4h3cck 415 11 ( ( -LRB- cord-267475-6f4h3cck 415 12 Fouillot Fouillot NNP cord-267475-6f4h3cck 415 13 et et NNP cord-267475-6f4h3cck 415 14 al al NNP cord-267475-6f4h3cck 415 15 . . NNP cord-267475-6f4h3cck 415 16 , , , cord-267475-6f4h3cck 415 17 1993 1993 CD cord-267475-6f4h3cck 415 18 ; ; : cord-267475-6f4h3cck 415 19 Hwang Hwang NNP cord-267475-6f4h3cck 415 20 and and CC cord-267475-6f4h3cck 415 21 Su Su NNP cord-267475-6f4h3cck 415 22 , , , cord-267475-6f4h3cck 415 23 1998 1998 CD cord-267475-6f4h3cck 415 24 ) ) -RRB- cord-267475-6f4h3cck 415 25 also also RB cord-267475-6f4h3cck 415 26 discuss discuss VBP cord-267475-6f4h3cck 415 27 some some DT cord-267475-6f4h3cck 415 28 alternative alternative JJ cord-267475-6f4h3cck 415 29 possibilities possibility NNS cord-267475-6f4h3cck 415 30 vis vis FW cord-267475-6f4h3cck 415 31 - - HYPH cord-267475-6f4h3cck 415 32 à à FW cord-267475-6f4h3cck 415 33 - - HYPH cord-267475-6f4h3cck 415 34 vis vis FW cord-267475-6f4h3cck 415 35 translation translation NN cord-267475-6f4h3cck 415 36 of of IN cord-267475-6f4h3cck 415 37 polymerase polymerase NN cord-267475-6f4h3cck 415 38 . . . cord-267475-6f4h3cck 416 1 ( ( -LRB- cord-267475-6f4h3cck 416 2 C C NNP cord-267475-6f4h3cck 416 3 ) ) -RRB- cord-267475-6f4h3cck 417 1 The the DT cord-267475-6f4h3cck 417 2 first first JJ cord-267475-6f4h3cck 417 3 AUG AUG NNP cord-267475-6f4h3cck 417 4 codon codon NN cord-267475-6f4h3cck 417 5 in in IN cord-267475-6f4h3cck 418 1 rat rat NN cord-267475-6f4h3cck 418 2 histone histone NN cord-267475-6f4h3cck 418 3 H4 H4 NNP cord-267475-6f4h3cck 418 4 mRNA mrna NN cord-267475-6f4h3cck 418 5 initiates initiate VBZ cord-267475-6f4h3cck 418 6 translation translation NN cord-267475-6f4h3cck 418 7 of of IN cord-267475-6f4h3cck 418 8 the the DT cord-267475-6f4h3cck 418 9 full full JJ cord-267475-6f4h3cck 418 10 - - HYPH cord-267475-6f4h3cck 418 11 length length NN cord-267475-6f4h3cck 418 12 protein protein NN cord-267475-6f4h3cck 418 13 . . . cord-267475-6f4h3cck 419 1 The the DT cord-267475-6f4h3cck 419 2 second second JJ cord-267475-6f4h3cck 419 3 AUG AUG NNP cord-267475-6f4h3cck 419 4 , , , cord-267475-6f4h3cck 419 5 85 85 CD cord-267475-6f4h3cck 419 6 codons codon NNS cord-267475-6f4h3cck 419 7 downstream downstream RB cord-267475-6f4h3cck 419 8 and and CC cord-267475-6f4h3cck 419 9 in in IN cord-267475-6f4h3cck 419 10 the the DT cord-267475-6f4h3cck 419 11 same same JJ cord-267475-6f4h3cck 419 12 reading reading NN cord-267475-6f4h3cck 419 13 frame frame NN cord-267475-6f4h3cck 419 14 , , , cord-267475-6f4h3cck 419 15 initiates initiate VBZ cord-267475-6f4h3cck 419 16 production production NN cord-267475-6f4h3cck 419 17 of of IN cord-267475-6f4h3cck 419 18 a a DT cord-267475-6f4h3cck 419 19 peptide peptide NN cord-267475-6f4h3cck 419 20 which which WDT cord-267475-6f4h3cck 419 21 has have VBZ cord-267475-6f4h3cck 419 22 growth growth NN cord-267475-6f4h3cck 419 23 - - HYPH cord-267475-6f4h3cck 419 24 regulatory regulatory JJ cord-267475-6f4h3cck 419 25 properties property NNS cord-267475-6f4h3cck 420 1 ( ( -LRB- cord-267475-6f4h3cck 420 2 Bab Bab NNP cord-267475-6f4h3cck 420 3 et et NNP cord-267475-6f4h3cck 420 4 al al NNP cord-267475-6f4h3cck 420 5 . . NNP cord-267475-6f4h3cck 420 6 , , , cord-267475-6f4h3cck 420 7 1999 1999 CD cord-267475-6f4h3cck 420 8 ) ) -RRB- cord-267475-6f4h3cck 420 9 . . . cord-267475-6f4h3cck 421 1 ( ( -LRB- cord-267475-6f4h3cck 421 2 D d NN cord-267475-6f4h3cck 421 3 ) ) -RRB- cord-267475-6f4h3cck 422 1 With with IN cord-267475-6f4h3cck 422 2 rat rat NN cord-267475-6f4h3cck 422 3 A A NNP cord-267475-6f4h3cck 422 4 2A 2a NN cord-267475-6f4h3cck 422 5 R r NN cord-267475-6f4h3cck 422 6 adenosine adenosine NN cord-267475-6f4h3cck 422 7 receptor receptor NN cord-267475-6f4h3cck 422 8 mRNA mRNA NNP cord-267475-6f4h3cck 422 9 , , , cord-267475-6f4h3cck 422 10 an an DT cord-267475-6f4h3cck 422 11 overlapping overlap VBG cord-267475-6f4h3cck 422 12 upORF uporf NN cord-267475-6f4h3cck 422 13 that that WDT cord-267475-6f4h3cck 422 14 initiates initiate VBZ cord-267475-6f4h3cck 422 15 at at IN cord-267475-6f4h3cck 422 16 an an DT cord-267475-6f4h3cck 422 17 AUG AUG NNP cord-267475-6f4h3cck 422 18 codon codon NN cord-267475-6f4h3cck 422 19 in in IN cord-267475-6f4h3cck 422 20 a a DT cord-267475-6f4h3cck 422 21 strong strong JJ cord-267475-6f4h3cck 422 22 context context NN cord-267475-6f4h3cck 422 23 is be VBZ cord-267475-6f4h3cck 422 24 used use VBN cord-267475-6f4h3cck 422 25 to to TO cord-267475-6f4h3cck 422 26 minimize minimize VB cord-267475-6f4h3cck 422 27 production production NN cord-267475-6f4h3cck 422 28 of of IN cord-267475-6f4h3cck 422 29 A a DT cord-267475-6f4h3cck 422 30 2A 2a NN cord-267475-6f4h3cck 422 31 R r NN cord-267475-6f4h3cck 422 32 protein protein NN cord-267475-6f4h3cck 422 33 . . . cord-267475-6f4h3cck 423 1 The the DT cord-267475-6f4h3cck 423 2 overlapping overlap VBG cord-267475-6f4h3cck 423 3 arrangement arrangement NN cord-267475-6f4h3cck 423 4 precludes preclude VBZ cord-267475-6f4h3cck 423 5 reinitiation reinitiation NN cord-267475-6f4h3cck 423 6 but but CC cord-267475-6f4h3cck 423 7 the the DT cord-267475-6f4h3cck 423 8 not not RB cord-267475-6f4h3cck 423 9 - - HYPH cord-267475-6f4h3cck 423 10 quite quite RB cord-267475-6f4h3cck 423 11 - - HYPH cord-267475-6f4h3cck 423 12 perfect perfect JJ cord-267475-6f4h3cck 423 13 context context NN cord-267475-6f4h3cck 423 14 at at IN cord-267475-6f4h3cck 423 15 the the DT cord-267475-6f4h3cck 423 16 upstream upstream JJ cord-267475-6f4h3cck 423 17 start start NN cord-267475-6f4h3cck 423 18 site site NN cord-267475-6f4h3cck 423 19 allows allow VBZ cord-267475-6f4h3cck 423 20 low low JJ cord-267475-6f4h3cck 423 21 - - HYPH cord-267475-6f4h3cck 423 22 level level NN cord-267475-6f4h3cck 423 23 leaky leaky JJ cord-267475-6f4h3cck 423 24 scanning scanning NN cord-267475-6f4h3cck 423 25 . . . cord-267475-6f4h3cck 424 1 This this DT cord-267475-6f4h3cck 424 2 interpretation interpretation NN cord-267475-6f4h3cck 424 3 is be VBZ cord-267475-6f4h3cck 424 4 supported support VBN cord-267475-6f4h3cck 424 5 by by IN cord-267475-6f4h3cck 424 6 the the DT cord-267475-6f4h3cck 424 7 observed observe VBN cord-267475-6f4h3cck 424 8 ten ten CD cord-267475-6f4h3cck 424 9 - - HYPH cord-267475-6f4h3cck 424 10 fold fold JJ cord-267475-6f4h3cck 424 11 increase increase NN cord-267475-6f4h3cck 424 12 in in IN cord-267475-6f4h3cck 424 13 translation translation NN cord-267475-6f4h3cck 424 14 of of IN cord-267475-6f4h3cck 424 15 A a DT cord-267475-6f4h3cck 424 16 2A 2a CD cord-267475-6f4h3cck 424 17 R r NN cord-267475-6f4h3cck 424 18 in in IN cord-267475-6f4h3cck 424 19 vivo vivo NN cord-267475-6f4h3cck 424 20 when when WRB cord-267475-6f4h3cck 424 21 the the DT cord-267475-6f4h3cck 424 22 start start NN cord-267475-6f4h3cck 424 23 codon codon NN cord-267475-6f4h3cck 424 24 of of IN cord-267475-6f4h3cck 424 25 the the DT cord-267475-6f4h3cck 424 26 upORF uporf JJ cord-267475-6f4h3cck 424 27 was be VBD cord-267475-6f4h3cck 424 28 eliminated eliminate VBN cord-267475-6f4h3cck 424 29 ( ( -LRB- cord-267475-6f4h3cck 424 30 Lee Lee NNP cord-267475-6f4h3cck 424 31 et et NNP cord-267475-6f4h3cck 424 32 al al NNP cord-267475-6f4h3cck 424 33 . . NNP cord-267475-6f4h3cck 424 34 , , , cord-267475-6f4h3cck 424 35 1999 1999 CD cord-267475-6f4h3cck 424 36 ) ) -RRB- cord-267475-6f4h3cck 424 37 . . . cord-267475-6f4h3cck 425 1 Via via IN cord-267475-6f4h3cck 425 2 a a DT cord-267475-6f4h3cck 425 3 second second JJ cord-267475-6f4h3cck 425 4 promoter promoter NN cord-267475-6f4h3cck 425 5 , , , cord-267475-6f4h3cck 425 6 the the DT cord-267475-6f4h3cck 425 7 rat rat NN cord-267475-6f4h3cck 425 8 A A NNP cord-267475-6f4h3cck 425 9 2A 2a CD cord-267475-6f4h3cck 425 10 -R -R : cord-267475-6f4h3cck 425 11 gene gene NN cord-267475-6f4h3cck 425 12 produces produce VBZ cord-267475-6f4h3cck 425 13 some some DT cord-267475-6f4h3cck 425 14 transcripts transcript NNS cord-267475-6f4h3cck 425 15 with with IN cord-267475-6f4h3cck 425 16 additional additional JJ cord-267475-6f4h3cck 425 17 upORFs uporfs NN cord-267475-6f4h3cck 425 18 , , , cord-267475-6f4h3cck 425 19 but but CC cord-267475-6f4h3cck 425 20 no no DT cord-267475-6f4h3cck 425 21 transcript transcript NN cord-267475-6f4h3cck 425 22 has have VBZ cord-267475-6f4h3cck 425 23 yet yet RB cord-267475-6f4h3cck 425 24 been be VBN cord-267475-6f4h3cck 425 25 found find VBN cord-267475-6f4h3cck 425 26 that that WDT cord-267475-6f4h3cck 425 27 lacks lack VBZ cord-267475-6f4h3cck 425 28 the the DT cord-267475-6f4h3cck 425 29 inhibitory inhibitory JJ cord-267475-6f4h3cck 425 30 upORF uporf NN cord-267475-6f4h3cck 425 31 discussed discuss VBN cord-267475-6f4h3cck 425 32 here here RB cord-267475-6f4h3cck 425 33 . . . cord-267475-6f4h3cck 426 1 Here here RB cord-267475-6f4h3cck 426 2 and and CC cord-267475-6f4h3cck 426 3 in in IN cord-267475-6f4h3cck 426 4 Fig Fig NNP cord-267475-6f4h3cck 426 5 . . . cord-267475-6f4h3cck 427 1 3 3 LS cord-267475-6f4h3cck 427 2 , , , cord-267475-6f4h3cck 427 3 the the DT cord-267475-6f4h3cck 427 4 major major JJ cord-267475-6f4h3cck 427 5 coding coding NN cord-267475-6f4h3cck 427 6 domain domain NN cord-267475-6f4h3cck 427 7 is be VBZ cord-267475-6f4h3cck 427 8 shaded shade VBN cord-267475-6f4h3cck 427 9 gray gray JJ cord-267475-6f4h3cck 427 10 . . . cord-267475-6f4h3cck 428 1 Small small JJ cord-267475-6f4h3cck 428 2 regulatory regulatory JJ cord-267475-6f4h3cck 428 3 ORFs orfs NN cord-267475-6f4h3cck 428 4 ( ( -LRB- cord-267475-6f4h3cck 428 5 blue blue JJ cord-267475-6f4h3cck 428 6 rectangles rectangle NNS cord-267475-6f4h3cck 428 7 ) ) -RRB- cord-267475-6f4h3cck 428 8 are be VBP cord-267475-6f4h3cck 428 9 not not RB cord-267475-6f4h3cck 428 10 drawn draw VBN cord-267475-6f4h3cck 428 11 to to TO cord-267475-6f4h3cck 428 12 scale scale VB cord-267475-6f4h3cck 428 13 . . . cord-267475-6f4h3cck 429 1 that that DT cord-267475-6f4h3cck 429 2 view view NN cord-267475-6f4h3cck 429 3 ( ( -LRB- cord-267475-6f4h3cck 429 4 Kozak Kozak NNP cord-267475-6f4h3cck 429 5 , , , cord-267475-6f4h3cck 429 6 2001b 2001b CD cord-267475-6f4h3cck 429 7 ) ) -RRB- cord-267475-6f4h3cck 429 8 . . . cord-267475-6f4h3cck 430 1 Indeed indeed RB cord-267475-6f4h3cck 430 2 many many JJ cord-267475-6f4h3cck 430 3 studies study NNS cord-267475-6f4h3cck 430 4 have have VBP cord-267475-6f4h3cck 430 5 shown show VBN cord-267475-6f4h3cck 430 6 that that IN cord-267475-6f4h3cck 430 7 the the DT cord-267475-6f4h3cck 430 8 strongest strong JJS cord-267475-6f4h3cck 430 9 inhibition inhibition NN cord-267475-6f4h3cck 430 10 is be VBZ cord-267475-6f4h3cck 430 11 caused cause VBN cord-267475-6f4h3cck 430 12 by by IN cord-267475-6f4h3cck 430 13 an an DT cord-267475-6f4h3cck 430 14 upORF uporf NN cord-267475-6f4h3cck 430 15 that that WDT cord-267475-6f4h3cck 430 16 overlaps overlap VBZ cord-267475-6f4h3cck 430 17 the the DT cord-267475-6f4h3cck 430 18 start start NN cord-267475-6f4h3cck 430 19 of of IN cord-267475-6f4h3cck 430 20 the the DT cord-267475-6f4h3cck 430 21 downstream downstream JJ cord-267475-6f4h3cck 430 22 cistron cistron NN cord-267475-6f4h3cck 430 23 ( ( -LRB- cord-267475-6f4h3cck 430 24 Babik Babik NNP cord-267475-6f4h3cck 430 25 et et NNP cord-267475-6f4h3cck 430 26 al al NNP cord-267475-6f4h3cck 430 27 . . NNP cord-267475-6f4h3cck 430 28 , , , cord-267475-6f4h3cck 430 29 1999 1999 CD cord-267475-6f4h3cck 430 30 ; ; : cord-267475-6f4h3cck 430 31 Bates Bates NNP cord-267475-6f4h3cck 430 32 et et NNP cord-267475-6f4h3cck 430 33 al al NNP cord-267475-6f4h3cck 430 34 . . NNP cord-267475-6f4h3cck 430 35 , , , cord-267475-6f4h3cck 430 36 1991 1991 CD cord-267475-6f4h3cck 430 37 ; ; : cord-267475-6f4h3cck 430 38 Byrne Byrne NNP cord-267475-6f4h3cck 430 39 et et NNP cord-267475-6f4h3cck 430 40 al al NNP cord-267475-6f4h3cck 430 41 . . . cord-267475-6f4h3cck 431 1 , , , cord-267475-6f4h3cck 431 2 1995 1995 CD cord-267475-6f4h3cck 431 3 ; ; : cord-267475-6f4h3cck 431 4 Cao Cao NNP cord-267475-6f4h3cck 431 5 and and CC cord-267475-6f4h3cck 431 6 Geballe Geballe NNP cord-267475-6f4h3cck 431 7 , , , cord-267475-6f4h3cck 431 8 1995 1995 CD cord-267475-6f4h3cck 431 9 ; ; : cord-267475-6f4h3cck 431 10 Ghilardi Ghilardi NNP cord-267475-6f4h3cck 431 11 et et NNP cord-267475-6f4h3cck 431 12 al al NNP cord-267475-6f4h3cck 431 13 . . NNP cord-267475-6f4h3cck 431 14 , , , cord-267475-6f4h3cck 431 15 1998 1998 CD cord-267475-6f4h3cck 431 16 ; ; : cord-267475-6f4h3cck 431 17 Hansen Hansen NNP cord-267475-6f4h3cck 431 18 et et NNP cord-267475-6f4h3cck 431 19 al al NNP cord-267475-6f4h3cck 431 20 . . NNP cord-267475-6f4h3cck 431 21 , , , cord-267475-6f4h3cck 431 22 2002 2002 CD cord-267475-6f4h3cck 431 23 ; ; : cord-267475-6f4h3cck 432 1 Kos Kos NNP cord-267475-6f4h3cck 432 2 et et NNP cord-267475-6f4h3cck 432 3 al al NNP cord-267475-6f4h3cck 432 4 . . . cord-267475-6f4h3cck 433 1 , , , cord-267475-6f4h3cck 433 2 2002 2002 CD cord-267475-6f4h3cck 433 3 ; ; : cord-267475-6f4h3cck 433 4 Lee Lee NNP cord-267475-6f4h3cck 433 5 et et NNP cord-267475-6f4h3cck 433 6 al al NNP cord-267475-6f4h3cck 433 7 . . NNP cord-267475-6f4h3cck 433 8 , , , cord-267475-6f4h3cck 433 9 1999 1999 CD cord-267475-6f4h3cck 433 10 ; ; : cord-267475-6f4h3cck 434 1 Liu Liu NNP cord-267475-6f4h3cck 434 2 et et NNP cord-267475-6f4h3cck 434 3 al al NNP cord-267475-6f4h3cck 434 4 . . NNP cord-267475-6f4h3cck 434 5 , , , cord-267475-6f4h3cck 434 6 1999 1999 CD cord-267475-6f4h3cck 434 7 ) ) -RRB- cord-267475-6f4h3cck 434 8 , , , cord-267475-6f4h3cck 434 9 which which WDT cord-267475-6f4h3cck 434 10 would would MD cord-267475-6f4h3cck 434 11 not not RB cord-267475-6f4h3cck 434 12 be be VB cord-267475-6f4h3cck 434 13 the the DT cord-267475-6f4h3cck 434 14 case case NN cord-267475-6f4h3cck 434 15 if if IN cord-267475-6f4h3cck 434 16 ribosomes ribosome NNS cord-267475-6f4h3cck 434 17 could could MD cord-267475-6f4h3cck 434 18 move move VB cord-267475-6f4h3cck 434 19 backwards backwards RB cord-267475-6f4h3cck 434 20 to to TO cord-267475-6f4h3cck 434 21 reinitiate reinitiate VB cord-267475-6f4h3cck 434 22 . . . cord-267475-6f4h3cck 435 1 The the DT cord-267475-6f4h3cck 435 2 size size NN cord-267475-6f4h3cck 435 3 of of IN cord-267475-6f4h3cck 435 4 the the DT cord-267475-6f4h3cck 435 5 first first JJ cord-267475-6f4h3cck 435 6 ORF ORF NNP cord-267475-6f4h3cck 435 7 is be VBZ cord-267475-6f4h3cck 435 8 a a DT cord-267475-6f4h3cck 435 9 major major JJ cord-267475-6f4h3cck 435 10 limitation limitation NN cord-267475-6f4h3cck 435 11 on on IN cord-267475-6f4h3cck 435 12 reinitiation reinitiation NN cord-267475-6f4h3cck 435 13 in in IN cord-267475-6f4h3cck 435 14 eukaryotes eukaryote NNS cord-267475-6f4h3cck 435 15 : : : cord-267475-6f4h3cck 435 16 reinitiation reinitiation NN cord-267475-6f4h3cck 435 17 can can MD cord-267475-6f4h3cck 435 18 occur occur VB cord-267475-6f4h3cck 435 19 following follow VBG cord-267475-6f4h3cck 435 20 the the DT cord-267475-6f4h3cck 435 21 translation translation NN cord-267475-6f4h3cck 435 22 of of IN cord-267475-6f4h3cck 435 23 a a DT cord-267475-6f4h3cck 435 24 ' ' `` cord-267475-6f4h3cck 435 25 minicistron minicistron NN cord-267475-6f4h3cck 435 26 ' ' '' cord-267475-6f4h3cck 435 27 ( ( -LRB- cord-267475-6f4h3cck 435 28 a a DT cord-267475-6f4h3cck 435 29 small small JJ cord-267475-6f4h3cck 435 30 first first JJ cord-267475-6f4h3cck 435 31 ORF ORF NNP cord-267475-6f4h3cck 435 32 ) ) -RRB- cord-267475-6f4h3cck 435 33 but but CC cord-267475-6f4h3cck 435 34 not not RB cord-267475-6f4h3cck 435 35 following follow VBG cord-267475-6f4h3cck 435 36 the the DT cord-267475-6f4h3cck 435 37 translation translation NN cord-267475-6f4h3cck 435 38 of of IN cord-267475-6f4h3cck 435 39 a a DT cord-267475-6f4h3cck 435 40 full full JJ cord-267475-6f4h3cck 435 41 - - HYPH cord-267475-6f4h3cck 435 42 length length NN cord-267475-6f4h3cck 435 43 5 5 CD cord-267475-6f4h3cck 435 44 0 0 CD cord-267475-6f4h3cck 435 45 cistron cistron NN cord-267475-6f4h3cck 435 46 . . . cord-267475-6f4h3cck 436 1 The the DT cord-267475-6f4h3cck 436 2 long long JJ cord-267475-6f4h3cck 436 3 list list NN cord-267475-6f4h3cck 436 4 of of IN cord-267475-6f4h3cck 436 5 mRNAs mRNAs NNPS cord-267475-6f4h3cck 436 6 that that WDT cord-267475-6f4h3cck 436 7 contain contain VBP cord-267475-6f4h3cck 436 8 silent silent JJ cord-267475-6f4h3cck 436 9 3 3 CD cord-267475-6f4h3cck 436 10 0 0 CD cord-267475-6f4h3cck 436 11 cistrons cistron NNS cord-267475-6f4h3cck 436 12 ( ( -LRB- cord-267475-6f4h3cck 436 13 Table table NN cord-267475-6f4h3cck 436 14 1 1 CD cord-267475-6f4h3cck 436 15 ) ) -RRB- cord-267475-6f4h3cck 436 16 underscores underscore VBZ cord-267475-6f4h3cck 436 17 the the DT cord-267475-6f4h3cck 436 18 point point NN cord-267475-6f4h3cck 436 19 . . . cord-267475-6f4h3cck 437 1 The the DT cord-267475-6f4h3cck 437 2 only only JJ cord-267475-6f4h3cck 437 3 apparent apparent JJ cord-267475-6f4h3cck 437 4 exception exception NN cord-267475-6f4h3cck 437 5 occurs occur VBZ cord-267475-6f4h3cck 437 6 with with IN cord-267475-6f4h3cck 437 7 cauliflower cauliflower NN cord-267475-6f4h3cck 437 8 mosaic mosaic JJ cord-267475-6f4h3cck 437 9 virus virus NN cord-267475-6f4h3cck 437 10 , , , cord-267475-6f4h3cck 437 11 where where WRB cord-267475-6f4h3cck 437 12 a a DT cord-267475-6f4h3cck 437 13 protein protein NN cord-267475-6f4h3cck 437 14 encoded encode VBN cord-267475-6f4h3cck 437 15 by by IN cord-267475-6f4h3cck 437 16 the the DT cord-267475-6f4h3cck 437 17 virus virus NN cord-267475-6f4h3cck 437 18 appears appear VBZ cord-267475-6f4h3cck 437 19 to to TO cord-267475-6f4h3cck 437 20 promote promote VB cord-267475-6f4h3cck 437 21 reinitiation reinitiation NN cord-267475-6f4h3cck 437 22 following follow VBG cord-267475-6f4h3cck 437 23 the the DT cord-267475-6f4h3cck 437 24 translation translation NN cord-267475-6f4h3cck 437 25 of of IN cord-267475-6f4h3cck 437 26 a a DT cord-267475-6f4h3cck 437 27 full full JJ cord-267475-6f4h3cck 437 28 - - HYPH cord-267475-6f4h3cck 437 29 length length NN cord-267475-6f4h3cck 437 30 first first JJ cord-267475-6f4h3cck 437 31 cistron cistron NN cord-267475-6f4h3cck 437 32 ( ( -LRB- cord-267475-6f4h3cck 437 33 Park Park NNP cord-267475-6f4h3cck 437 34 et et FW cord-267475-6f4h3cck 437 35 al al NNP cord-267475-6f4h3cck 437 36 . . NNP cord-267475-6f4h3cck 437 37 , , , cord-267475-6f4h3cck 437 38 2001 2001 CD cord-267475-6f4h3cck 437 39 ) ) -RRB- cord-267475-6f4h3cck 437 40 . . . cord-267475-6f4h3cck 438 1 The the DT cord-267475-6f4h3cck 438 2 reason reason NN cord-267475-6f4h3cck 438 3 why why WRB cord-267475-6f4h3cck 438 4 reinitiation reinitiation NN cord-267475-6f4h3cck 438 5 is be VBZ cord-267475-6f4h3cck 438 6 usually usually RB cord-267475-6f4h3cck 438 7 restricted restrict VBN cord-267475-6f4h3cck 438 8 by by IN cord-267475-6f4h3cck 438 9 the the DT cord-267475-6f4h3cck 438 10 size size NN cord-267475-6f4h3cck 438 11 of of IN cord-267475-6f4h3cck 438 12 the the DT cord-267475-6f4h3cck 438 13 first first JJ cord-267475-6f4h3cck 438 14 ORF ORF NNP cord-267475-6f4h3cck 438 15 is be VBZ cord-267475-6f4h3cck 438 16 not not RB cord-267475-6f4h3cck 438 17 known know VBN cord-267475-6f4h3cck 438 18 , , , cord-267475-6f4h3cck 438 19 but but CC cord-267475-6f4h3cck 438 20 a a DT cord-267475-6f4h3cck 438 21 possible possible JJ cord-267475-6f4h3cck 438 22 explanation explanation NN cord-267475-6f4h3cck 438 23 is be VBZ cord-267475-6f4h3cck 438 24 that that IN cord-267475-6f4h3cck 438 25 certain certain JJ cord-267475-6f4h3cck 438 26 initiation initiation NN cord-267475-6f4h3cck 438 27 factors factor NNS cord-267475-6f4h3cck 438 28 dissociate dissociate VBP cord-267475-6f4h3cck 438 29 from from IN cord-267475-6f4h3cck 438 30 the the DT cord-267475-6f4h3cck 438 31 ribosome ribosome NN cord-267475-6f4h3cck 438 32 only only RB cord-267475-6f4h3cck 438 33 gradually gradually RB cord-267475-6f4h3cck 438 34 during during IN cord-267475-6f4h3cck 438 35 the the DT cord-267475-6f4h3cck 438 36 course course NN cord-267475-6f4h3cck 438 37 of of IN cord-267475-6f4h3cck 438 38 elongation elongation NN cord-267475-6f4h3cck 438 39 . . . cord-267475-6f4h3cck 439 1 If if IN cord-267475-6f4h3cck 439 2 the the DT cord-267475-6f4h3cck 439 3 elongation elongation NN cord-267475-6f4h3cck 439 4 phase phase NN cord-267475-6f4h3cck 439 5 is be VBZ cord-267475-6f4h3cck 439 6 brief brief JJ cord-267475-6f4h3cck 439 7 -i.e -i.e . cord-267475-6f4h3cck 439 8 . . . cord-267475-6f4h3cck 440 1 if if IN cord-267475-6f4h3cck 440 2 the the DT cord-267475-6f4h3cck 440 3 first first JJ cord-267475-6f4h3cck 440 4 ORF ORF NNP cord-267475-6f4h3cck 440 5 is be VBZ cord-267475-6f4h3cck 440 6 a a DT cord-267475-6f4h3cck 440 7 Fig fig NN cord-267475-6f4h3cck 440 8 . . . cord-267475-6f4h3cck 441 1 3 3 LS cord-267475-6f4h3cck 441 2 . . . cord-267475-6f4h3cck 442 1 Small small JJ cord-267475-6f4h3cck 442 2 upstream upstream JJ cord-267475-6f4h3cck 442 3 ORFs orfs NN cord-267475-6f4h3cck 442 4 in in IN cord-267475-6f4h3cck 442 5 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 442 6 mRNAs mrnas CD cord-267475-6f4h3cck 442 7 function function VBP cord-267475-6f4h3cck 442 8 in in IN cord-267475-6f4h3cck 442 9 various various JJ cord-267475-6f4h3cck 442 10 ways way NNS cord-267475-6f4h3cck 442 11 to to TO cord-267475-6f4h3cck 442 12 modulate modulate VB cord-267475-6f4h3cck 442 13 translation translation NN cord-267475-6f4h3cck 442 14 . . . cord-267475-6f4h3cck 443 1 Only only RB cord-267475-6f4h3cck 443 2 the the DT cord-267475-6f4h3cck 443 3 5 5 CD cord-267475-6f4h3cck 443 4 0 0 CD cord-267475-6f4h3cck 443 5 end end NN cord-267475-6f4h3cck 443 6 of of IN cord-267475-6f4h3cck 443 7 each each DT cord-267475-6f4h3cck 443 8 mRNA mrna NN cord-267475-6f4h3cck 443 9 is be VBZ cord-267475-6f4h3cck 443 10 depicted depict VBN cord-267475-6f4h3cck 443 11 . . . cord-267475-6f4h3cck 444 1 ( ( -LRB- cord-267475-6f4h3cck 444 2 A a NN cord-267475-6f4h3cck 444 3 ) ) -RRB- cord-267475-6f4h3cck 445 1 The the DT cord-267475-6f4h3cck 445 2 presence presence NN cord-267475-6f4h3cck 445 3 of of IN cord-267475-6f4h3cck 445 4 upORFs uporfs JJ cord-267475-6f4h3cck 445 5 forces force NNS cord-267475-6f4h3cck 445 6 translation translation NN cord-267475-6f4h3cck 445 7 of of IN cord-267475-6f4h3cck 445 8 the the DT cord-267475-6f4h3cck 445 9 major major JJ cord-267475-6f4h3cck 445 10 ORF ORF NNP cord-267475-6f4h3cck 445 11 to to TO cord-267475-6f4h3cck 445 12 occur occur VB cord-267475-6f4h3cck 445 13 by by IN cord-267475-6f4h3cck 445 14 a a DT cord-267475-6f4h3cck 445 15 reinitiation reinitiation NN cord-267475-6f4h3cck 445 16 mechanism mechanism NN cord-267475-6f4h3cck 445 17 , , , cord-267475-6f4h3cck 445 18 which which WDT cord-267475-6f4h3cck 445 19 is be VBZ cord-267475-6f4h3cck 445 20 usually usually RB cord-267475-6f4h3cck 445 21 inefficient inefficient JJ cord-267475-6f4h3cck 445 22 . . . cord-267475-6f4h3cck 446 1 The the DT cord-267475-6f4h3cck 446 2 extent extent NN cord-267475-6f4h3cck 446 3 of of IN cord-267475-6f4h3cck 446 4 inhibition inhibition NN cord-267475-6f4h3cck 446 5 depends depend VBZ cord-267475-6f4h3cck 446 6 on on IN cord-267475-6f4h3cck 446 7 the the DT cord-267475-6f4h3cck 446 8 number number NN cord-267475-6f4h3cck 446 9 and and CC cord-267475-6f4h3cck 446 10 arrangement arrangement NN cord-267475-6f4h3cck 446 11 of of IN cord-267475-6f4h3cck 446 12 upORFs upORFs NNP cord-267475-6f4h3cck 446 13 and and CC cord-267475-6f4h3cck 446 14 whether whether IN cord-267475-6f4h3cck 446 15 the the DT cord-267475-6f4h3cck 446 16 context context NN cord-267475-6f4h3cck 446 17 flanking flank VBG cord-267475-6f4h3cck 446 18 the the DT cord-267475-6f4h3cck 446 19 upstream upstream JJ cord-267475-6f4h3cck 446 20 start start NN cord-267475-6f4h3cck 446 21 codon(s codon(s NNP cord-267475-6f4h3cck 446 22 ) ) -RRB- cord-267475-6f4h3cck 446 23 allows allow VBZ cord-267475-6f4h3cck 446 24 some some DT cord-267475-6f4h3cck 446 25 escape escape NN cord-267475-6f4h3cck 446 26 via via IN cord-267475-6f4h3cck 446 27 leaky leaky JJ cord-267475-6f4h3cck 446 28 scanning scanning NN cord-267475-6f4h3cck 446 29 . . . cord-267475-6f4h3cck 447 1 ( ( -LRB- cord-267475-6f4h3cck 447 2 B b NN cord-267475-6f4h3cck 447 3 ) ) -RRB- cord-267475-6f4h3cck 448 1 Because because IN cord-267475-6f4h3cck 448 2 reinitiation reinitiation NN cord-267475-6f4h3cck 448 3 can can MD cord-267475-6f4h3cck 448 4 occur occur VB cord-267475-6f4h3cck 448 5 only only RB cord-267475-6f4h3cck 448 6 in in IN cord-267475-6f4h3cck 448 7 the the DT cord-267475-6f4h3cck 448 8 forward forward JJ cord-267475-6f4h3cck 448 9 direction direction NN cord-267475-6f4h3cck 448 10 , , , cord-267475-6f4h3cck 448 11 an an DT cord-267475-6f4h3cck 448 12 overlapping overlap VBG cord-267475-6f4h3cck 448 13 upORF uporf NN cord-267475-6f4h3cck 448 14 strongly strongly RB cord-267475-6f4h3cck 448 15 impairs impair VBZ cord-267475-6f4h3cck 448 16 translation translation NN cord-267475-6f4h3cck 448 17 of of IN cord-267475-6f4h3cck 448 18 the the DT cord-267475-6f4h3cck 448 19 major major JJ cord-267475-6f4h3cck 448 20 ORF ORF NNP cord-267475-6f4h3cck 448 21 . . . cord-267475-6f4h3cck 449 1 ( ( -LRB- cord-267475-6f4h3cck 449 2 C C NNP cord-267475-6f4h3cck 449 3 ) ) -RRB- cord-267475-6f4h3cck 450 1 Whereas whereas IN cord-267475-6f4h3cck 450 2 type type NN cord-267475-6f4h3cck 450 3 B b NN cord-267475-6f4h3cck 450 4 mRNAs mrnas PRP cord-267475-6f4h3cck 450 5 have have VB cord-267475-6f4h3cck 450 6 a a DT cord-267475-6f4h3cck 450 7 single single JJ cord-267475-6f4h3cck 450 8 in in IN cord-267475-6f4h3cck 450 9 - - HYPH cord-267475-6f4h3cck 450 10 frame frame NN cord-267475-6f4h3cck 450 11 start start NN cord-267475-6f4h3cck 450 12 codon codon NN cord-267475-6f4h3cck 450 13 which which WDT cord-267475-6f4h3cck 450 14 is be VBZ cord-267475-6f4h3cck 450 15 bypassed bypass VBN cord-267475-6f4h3cck 450 16 due due IN cord-267475-6f4h3cck 450 17 to to IN cord-267475-6f4h3cck 450 18 the the DT cord-267475-6f4h3cck 450 19 overlapping overlap VBG cord-267475-6f4h3cck 450 20 upORF uporf JJ cord-267475-6f4h3cck 450 21 , , , cord-267475-6f4h3cck 450 22 type type NN cord-267475-6f4h3cck 450 23 C c NN cord-267475-6f4h3cck 450 24 mRNAs mrnas CD cord-267475-6f4h3cck 450 25 initiate initiate VBP cord-267475-6f4h3cck 450 26 from from IN cord-267475-6f4h3cck 450 27 two two CD cord-267475-6f4h3cck 451 1 in in IN cord-267475-6f4h3cck 451 2 - - HYPH cord-267475-6f4h3cck 451 3 frame frame NN cord-267475-6f4h3cck 451 4 start start NN cord-267475-6f4h3cck 451 5 codons codon NNS cord-267475-6f4h3cck 451 6 ; ; : cord-267475-6f4h3cck 451 7 the the DT cord-267475-6f4h3cck 451 8 upORF upORF NNP cord-267475-6f4h3cck 451 9 serves serve VBZ cord-267475-6f4h3cck 451 10 to to TO cord-267475-6f4h3cck 451 11 divert divert VB cord-267475-6f4h3cck 451 12 some some DT cord-267475-6f4h3cck 451 13 ribosomes ribosome NNS cord-267475-6f4h3cck 451 14 to to IN cord-267475-6f4h3cck 451 15 the the DT cord-267475-6f4h3cck 451 16 downstream downstream JJ cord-267475-6f4h3cck 451 17 start start NN cord-267475-6f4h3cck 451 18 site site NN cord-267475-6f4h3cck 451 19 . . . cord-267475-6f4h3cck 452 1 The the DT cord-267475-6f4h3cck 452 2 depicted depict VBN cord-267475-6f4h3cck 452 3 sequence sequence NN cord-267475-6f4h3cck 452 4 is be VBZ cord-267475-6f4h3cck 452 5 a a DT cord-267475-6f4h3cck 452 6 simplified simplified JJ cord-267475-6f4h3cck 452 7 representation representation NN cord-267475-6f4h3cck 452 8 of of IN cord-267475-6f4h3cck 452 9 GlyRS GlyRS NNP cord-267475-6f4h3cck 452 10 mRNA mRNA NNP cord-267475-6f4h3cck 453 1 ( ( -LRB- cord-267475-6f4h3cck 453 2 Mudge Mudge NNP cord-267475-6f4h3cck 453 3 et et NNP cord-267475-6f4h3cck 453 4 al al NNP cord-267475-6f4h3cck 453 5 . . NNP cord-267475-6f4h3cck 453 6 , , , cord-267475-6f4h3cck 453 7 1998 1998 CD cord-267475-6f4h3cck 453 8 ) ) -RRB- cord-267475-6f4h3cck 453 9 . . . cord-267475-6f4h3cck 454 1 Translation translation NN cord-267475-6f4h3cck 454 2 of of IN cord-267475-6f4h3cck 454 3 Bag-1 Bag-1 NNP cord-267475-6f4h3cck 454 4 mRNA mrna NN cord-267475-6f4h3cck 454 5 can can MD cord-267475-6f4h3cck 454 6 also also RB cord-267475-6f4h3cck 454 7 be be VB cord-267475-6f4h3cck 454 8 fitted fit VBN cord-267475-6f4h3cck 454 9 to to IN cord-267475-6f4h3cck 454 10 this this DT cord-267475-6f4h3cck 454 11 pattern pattern NN cord-267475-6f4h3cck 454 12 : : : cord-267475-6f4h3cck 454 13 the the DT cord-267475-6f4h3cck 454 14 first first JJ cord-267475-6f4h3cck 454 15 start start NN cord-267475-6f4h3cck 454 16 site site NN cord-267475-6f4h3cck 454 17 is be VBZ cord-267475-6f4h3cck 454 18 an an DT cord-267475-6f4h3cck 454 19 in in IN cord-267475-6f4h3cck 454 20 - - HYPH cord-267475-6f4h3cck 454 21 frame frame NN cord-267475-6f4h3cck 454 22 CUG CUG NNP cord-267475-6f4h3cck 454 23 codon codon NN cord-267475-6f4h3cck 454 24 which which WDT cord-267475-6f4h3cck 454 25 produces produce VBZ cord-267475-6f4h3cck 454 26 the the DT cord-267475-6f4h3cck 454 27 50 50 CD cord-267475-6f4h3cck 454 28 kDa kDa NNS cord-267475-6f4h3cck 454 29 form form NN cord-267475-6f4h3cck 454 30 of of IN cord-267475-6f4h3cck 454 31 Bag-1 Bag-1 NNP cord-267475-6f4h3cck 454 32 ; ; : cord-267475-6f4h3cck 454 33 the the DT cord-267475-6f4h3cck 454 34 next next JJ cord-267475-6f4h3cck 454 35 start start NN cord-267475-6f4h3cck 454 36 site site NN cord-267475-6f4h3cck 454 37 ( ( -LRB- cord-267475-6f4h3cck 454 38 AUG#1 AUG#1 NNP cord-267475-6f4h3cck 454 39 , , , cord-267475-6f4h3cck 454 40 out out RB cord-267475-6f4h3cck 454 41 - - HYPH cord-267475-6f4h3cck 454 42 of of IN cord-267475-6f4h3cck 454 43 - - HYPH cord-267475-6f4h3cck 454 44 frame frame NN cord-267475-6f4h3cck 454 45 ) ) -RRB- cord-267475-6f4h3cck 454 46 initiates initiate VBZ cord-267475-6f4h3cck 454 47 a a DT cord-267475-6f4h3cck 454 48 small small JJ cord-267475-6f4h3cck 454 49 upORF uporf NN cord-267475-6f4h3cck 454 50 within within IN cord-267475-6f4h3cck 454 51 which which WDT cord-267475-6f4h3cck 454 52 the the DT cord-267475-6f4h3cck 454 53 first first JJ cord-267475-6f4h3cck 454 54 in in IN cord-267475-6f4h3cck 454 55 - - HYPH cord-267475-6f4h3cck 454 56 frame frame NN cord-267475-6f4h3cck 455 1 AUG AUG NNP cord-267475-6f4h3cck 455 2 codon codon NN cord-267475-6f4h3cck 455 3 ( ( -LRB- cord-267475-6f4h3cck 455 4 AUG#2 AUG#2 NNP cord-267475-6f4h3cck 455 5 ) ) -RRB- cord-267475-6f4h3cck 455 6 resides reside VBZ cord-267475-6f4h3cck 455 7 , , , cord-267475-6f4h3cck 455 8 and and CC cord-267475-6f4h3cck 455 9 that that IN cord-267475-6f4h3cck 455 10 AUG AUG NNP cord-267475-6f4h3cck 455 11 is be VBZ cord-267475-6f4h3cck 455 12 thereby thereby RB cord-267475-6f4h3cck 455 13 skipped skip VBN cord-267475-6f4h3cck 455 14 ; ; : cord-267475-6f4h3cck 455 15 the the DT cord-267475-6f4h3cck 455 16 36 36 CD cord-267475-6f4h3cck 455 17 kDa kDa NNP cord-267475-6f4h3cck 455 18 form form NN cord-267475-6f4h3cck 455 19 of of IN cord-267475-6f4h3cck 455 20 Bag-1 Bag-1 NNP cord-267475-6f4h3cck 455 21 is be VBZ cord-267475-6f4h3cck 455 22 produced produce VBN cord-267475-6f4h3cck 455 23 from from IN cord-267475-6f4h3cck 455 24 AUG#3 AUG#3 NNP cord-267475-6f4h3cck 455 25 which which WDT cord-267475-6f4h3cck 455 26 is be VBZ cord-267475-6f4h3cck 455 27 accessed access VBN cord-267475-6f4h3cck 455 28 by by IN cord-267475-6f4h3cck 455 29 reinitiation reinitiation NN cord-267475-6f4h3cck 455 30 following follow VBG cord-267475-6f4h3cck 455 31 translation translation NN cord-267475-6f4h3cck 455 32 of of IN cord-267475-6f4h3cck 455 33 the the DT cord-267475-6f4h3cck 455 34 small small JJ cord-267475-6f4h3cck 455 35 upORF upORF . cord-267475-6f4h3cck 456 1 ( ( -LRB- cord-267475-6f4h3cck 456 2 Packham Packham NNP cord-267475-6f4h3cck 456 3 et et NNP cord-267475-6f4h3cck 456 4 al al NNP cord-267475-6f4h3cck 456 5 . . NNP cord-267475-6f4h3cck 456 6 , , , cord-267475-6f4h3cck 456 7 1997 1997 CD cord-267475-6f4h3cck 456 8 ) ) -RRB- cord-267475-6f4h3cck 456 9 . . . cord-267475-6f4h3cck 457 1 Some some DT cord-267475-6f4h3cck 457 2 other other JJ cord-267475-6f4h3cck 457 3 mRNAs mRNAs NNPS cord-267475-6f4h3cck 457 4 that that WDT cord-267475-6f4h3cck 457 5 use use VBP cord-267475-6f4h3cck 457 6 an an DT cord-267475-6f4h3cck 457 7 upORF uporf NN cord-267475-6f4h3cck 457 8 to to TO cord-267475-6f4h3cck 457 9 dodge dodge VB cord-267475-6f4h3cck 457 10 one one CD cord-267475-6f4h3cck 457 11 AUG AUG NNP cord-267475-6f4h3cck 457 12 codon codon NN cord-267475-6f4h3cck 457 13 in in IN cord-267475-6f4h3cck 457 14 favor favor NN cord-267475-6f4h3cck 457 15 of of IN cord-267475-6f4h3cck 457 16 another another DT cord-267475-6f4h3cck 457 17 are be VBP cord-267475-6f4h3cck 457 18 described describe VBN cord-267475-6f4h3cck 457 19 elsewhere elsewhere RB cord-267475-6f4h3cck 458 1 ( ( -LRB- cord-267475-6f4h3cck 458 2 Mittag Mittag NNP cord-267475-6f4h3cck 458 3 et et NNP cord-267475-6f4h3cck 458 4 al al NNP cord-267475-6f4h3cck 458 5 . . NNP cord-267475-6f4h3cck 458 6 , , , cord-267475-6f4h3cck 458 7 1997 1997 CD cord-267475-6f4h3cck 459 1 ; ; : cord-267475-6f4h3cck 459 2 Sarrazin Sarrazin NNP cord-267475-6f4h3cck 459 3 et et NNP cord-267475-6f4h3cck 459 4 al al NNP cord-267475-6f4h3cck 459 5 . . NNP cord-267475-6f4h3cck 459 6 , , , cord-267475-6f4h3cck 459 7 2000 2000 CD cord-267475-6f4h3cck 459 8 ) ) -RRB- cord-267475-6f4h3cck 459 9 . . . cord-267475-6f4h3cck 460 1 Note note VB cord-267475-6f4h3cck 460 2 that that IN cord-267475-6f4h3cck 460 3 the the DT cord-267475-6f4h3cck 460 4 reinitiation reinitiation NN cord-267475-6f4h3cck 460 5 shunt shunt NN cord-267475-6f4h3cck 460 6 as as IN cord-267475-6f4h3cck 460 7 here here RB cord-267475-6f4h3cck 460 8 defined define VBN cord-267475-6f4h3cck 460 9 adheres adhere VBZ cord-267475-6f4h3cck 460 10 to to IN cord-267475-6f4h3cck 460 11 the the DT cord-267475-6f4h3cck 460 12 linear linear JJ cord-267475-6f4h3cck 460 13 scanning scanning NN cord-267475-6f4h3cck 460 14 mechanism mechanism NN cord-267475-6f4h3cck 460 15 , , , cord-267475-6f4h3cck 460 16 unlike unlike IN cord-267475-6f4h3cck 460 17 a a DT cord-267475-6f4h3cck 460 18 shunt shunt NN cord-267475-6f4h3cck 460 19 postulated postulate VBN cord-267475-6f4h3cck 460 20 to to TO cord-267475-6f4h3cck 460 21 operate operate VB cord-267475-6f4h3cck 460 22 with with IN cord-267475-6f4h3cck 460 23 cauliflower cauliflower NN cord-267475-6f4h3cck 460 24 mosaic mosaic NNP cord-267475-6f4h3cck 460 25 virus virus NN cord-267475-6f4h3cck 461 1 mRNA mRNA NNP cord-267475-6f4h3cck 462 1 ( ( -LRB- cord-267475-6f4h3cck 462 2 Ryabova Ryabova NNP cord-267475-6f4h3cck 462 3 et et NNP cord-267475-6f4h3cck 462 4 al al NNP cord-267475-6f4h3cck 462 5 . . NNP cord-267475-6f4h3cck 462 6 , , , cord-267475-6f4h3cck 462 7 2000 2000 CD cord-267475-6f4h3cck 462 8 ) ) -RRB- cord-267475-6f4h3cck 462 9 . . . cord-267475-6f4h3cck 463 1 ( ( -LRB- cord-267475-6f4h3cck 463 2 D d NN cord-267475-6f4h3cck 463 3 ) ) -RRB- cord-267475-6f4h3cck 464 1 The the DT cord-267475-6f4h3cck 464 2 common common JJ cord-267475-6f4h3cck 464 3 feature feature NN cord-267475-6f4h3cck 464 4 of of IN cord-267475-6f4h3cck 464 5 mRNAs mRNAs NNPS cord-267475-6f4h3cck 464 6 that that WDT cord-267475-6f4h3cck 464 7 use use VBP cord-267475-6f4h3cck 464 8 mechanism mechanism NN cord-267475-6f4h3cck 464 9 D d NN cord-267475-6f4h3cck 464 10 is be VBZ cord-267475-6f4h3cck 464 11 inhibition inhibition NN cord-267475-6f4h3cck 464 12 of of IN cord-267475-6f4h3cck 464 13 translation translation NN cord-267475-6f4h3cck 464 14 in in IN cord-267475-6f4h3cck 464 15 cis cis NNP cord-267475-6f4h3cck 464 16 by by IN cord-267475-6f4h3cck 464 17 a a DT cord-267475-6f4h3cck 464 18 peptide peptide NN cord-267475-6f4h3cck 464 19 encoded encode VBN cord-267475-6f4h3cck 464 20 within within IN cord-267475-6f4h3cck 464 21 the the DT cord-267475-6f4h3cck 464 22 upORF uporf JJ cord-267475-6f4h3cck 464 23 . . . cord-267475-6f4h3cck 465 1 The the DT cord-267475-6f4h3cck 465 2 amino amino NN cord-267475-6f4h3cck 465 3 acid acid NN cord-267475-6f4h3cck 465 4 sequence sequence NN cord-267475-6f4h3cck 465 5 of of IN cord-267475-6f4h3cck 465 6 the the DT cord-267475-6f4h3cck 465 7 inhibitory inhibitory JJ cord-267475-6f4h3cck 465 8 peptide peptide NN cord-267475-6f4h3cck 465 9 is be VBZ cord-267475-6f4h3cck 465 10 different different JJ cord-267475-6f4h3cck 465 11 in in IN cord-267475-6f4h3cck 465 12 each each DT cord-267475-6f4h3cck 465 13 case case NN cord-267475-6f4h3cck 465 14 ( ( -LRB- cord-267475-6f4h3cck 465 15 Morris Morris NNP cord-267475-6f4h3cck 465 16 and and CC cord-267475-6f4h3cck 465 17 Geballe Geballe NNP cord-267475-6f4h3cck 465 18 , , , cord-267475-6f4h3cck 465 19 2000 2000 CD cord-267475-6f4h3cck 465 20 ) ) -RRB- cord-267475-6f4h3cck 465 21 . . . cord-267475-6f4h3cck 466 1 In in IN cord-267475-6f4h3cck 466 2 the the DT cord-267475-6f4h3cck 466 3 column column NN cord-267475-6f4h3cck 466 4 at at IN cord-267475-6f4h3cck 466 5 the the DT cord-267475-6f4h3cck 466 6 far far RB cord-267475-6f4h3cck 466 7 right right RB cord-267475-6f4h3cck 466 8 , , , cord-267475-6f4h3cck 466 9 asterisks asterisk NNS cord-267475-6f4h3cck 466 10 indicate indicate VBP cord-267475-6f4h3cck 466 11 examples example NNS cord-267475-6f4h3cck 466 12 in in IN cord-267475-6f4h3cck 466 13 which which WDT cord-267475-6f4h3cck 466 14 the the DT cord-267475-6f4h3cck 466 15 translational translational JJ cord-267475-6f4h3cck 466 16 control control NN cord-267475-6f4h3cck 466 17 mechanism mechanism NN cord-267475-6f4h3cck 466 18 is be VBZ cord-267475-6f4h3cck 466 19 regulated regulate VBN cord-267475-6f4h3cck 466 20 , , , cord-267475-6f4h3cck 466 21 e.g. e.g. RB cord-267475-6f4h3cck 466 22 via via IN cord-267475-6f4h3cck 466 23 a a DT cord-267475-6f4h3cck 466 24 change change NN cord-267475-6f4h3cck 466 25 in in IN cord-267475-6f4h3cck 466 26 concentration concentration NN cord-267475-6f4h3cck 466 27 of of IN cord-267475-6f4h3cck 466 28 eIF2 eIF2 NNP cord-267475-6f4h3cck 466 29 ( ( -LRB- cord-267475-6f4h3cck 466 30 GCN4 GCN4 NNP cord-267475-6f4h3cck 466 31 ) ) -RRB- cord-267475-6f4h3cck 466 32 or or CC cord-267475-6f4h3cck 466 33 arginine arginine NN cord-267475-6f4h3cck 466 34 ( ( -LRB- cord-267475-6f4h3cck 466 35 CPA1 CPA1 NNP cord-267475-6f4h3cck 466 36 ) ) -RRB- cord-267475-6f4h3cck 466 37 or or CC cord-267475-6f4h3cck 466 38 polyamines polyamine NNS cord-267475-6f4h3cck 466 39 ( ( -LRB- cord-267475-6f4h3cck 466 40 AdoMetDC AdoMetDC NNP cord-267475-6f4h3cck 466 41 ) ) -RRB- cord-267475-6f4h3cck 466 42 or or CC cord-267475-6f4h3cck 466 43 , , , cord-267475-6f4h3cck 466 44 more more RBR cord-267475-6f4h3cck 466 45 commonly commonly RB cord-267475-6f4h3cck 466 46 , , , cord-267475-6f4h3cck 466 47 via via IN cord-267475-6f4h3cck 466 48 an an DT cord-267475-6f4h3cck 466 49 alternative alternative JJ cord-267475-6f4h3cck 466 50 promoter promoter NN cord-267475-6f4h3cck 466 51 that that WDT cord-267475-6f4h3cck 466 52 generates generate VBZ cord-267475-6f4h3cck 466 53 a a DT cord-267475-6f4h3cck 466 54 simpler simple JJR cord-267475-6f4h3cck 466 55 form form NN cord-267475-6f4h3cck 466 56 of of IN cord-267475-6f4h3cck 466 57 mRNA mrna NN cord-267475-6f4h3cck 466 58 devoid devoid JJ cord-267475-6f4h3cck 466 59 of of IN cord-267475-6f4h3cck 466 60 upORFs upORFs NNP cord-267475-6f4h3cck 466 61 ( ( -LRB- cord-267475-6f4h3cck 466 62 c c NN cord-267475-6f4h3cck 466 63 - - HYPH cord-267475-6f4h3cck 466 64 mos mos NNP cord-267475-6f4h3cck 466 65 , , , cord-267475-6f4h3cck 466 66 MDM2 MDM2 NNP cord-267475-6f4h3cck 466 67 , , , cord-267475-6f4h3cck 466 68 IL-12 IL-12 NNP cord-267475-6f4h3cck 466 69 ; ; : cord-267475-6f4h3cck 466 70 see see VB cord-267475-6f4h3cck 466 71 text text NN cord-267475-6f4h3cck 466 72 for for IN cord-267475-6f4h3cck 466 73 other other JJ cord-267475-6f4h3cck 466 74 examples example NNS cord-267475-6f4h3cck 466 75 , , , cord-267475-6f4h3cck 466 76 e.g. e.g. RB cord-267475-6f4h3cck 466 77 in in IN cord-267475-6f4h3cck 467 1 Alderete Alderete NNP cord-267475-6f4h3cck 467 2 et et NNP cord-267475-6f4h3cck 467 3 al al NNP cord-267475-6f4h3cck 467 4 . . NNP cord-267475-6f4h3cck 467 5 , , , cord-267475-6f4h3cck 467 6 2001 2001 CD cord-267475-6f4h3cck 467 7 ) ) -RRB- cord-267475-6f4h3cck 467 8 . . . cord-267475-6f4h3cck 468 1 minicistron minicistron NNP cord-267475-6f4h3cck 469 1 -the -the DT cord-267475-6f4h3cck 469 2 factors factor NNS cord-267475-6f4h3cck 469 3 required require VBN cord-267475-6f4h3cck 469 4 for for IN cord-267475-6f4h3cck 469 5 reinitiation reinitiation NN cord-267475-6f4h3cck 469 6 would would MD cord-267475-6f4h3cck 469 7 still still RB cord-267475-6f4h3cck 469 8 be be VB cord-267475-6f4h3cck 469 9 present present JJ cord-267475-6f4h3cck 469 10 when when WRB cord-267475-6f4h3cck 469 11 the the DT cord-267475-6f4h3cck 469 12 40S 40s CD cord-267475-6f4h3cck 469 13 subunit subunit NN cord-267475-6f4h3cck 469 14 resumes resume VBZ cord-267475-6f4h3cck 469 15 scanning scan VBG cord-267475-6f4h3cck 469 16 . . . cord-267475-6f4h3cck 470 1 Although although IN cord-267475-6f4h3cck 470 2 the the DT cord-267475-6f4h3cck 470 3 postulated postulate VBN cord-267475-6f4h3cck 470 4 factors factor NNS cord-267475-6f4h3cck 470 5 have have VBP cord-267475-6f4h3cck 470 6 not not RB cord-267475-6f4h3cck 470 7 been be VBN cord-267475-6f4h3cck 470 8 identified identify VBN cord-267475-6f4h3cck 470 9 , , , cord-267475-6f4h3cck 470 10 there there EX cord-267475-6f4h3cck 470 11 is be VBZ cord-267475-6f4h3cck 470 12 evidence evidence NN cord-267475-6f4h3cck 470 13 for for IN cord-267475-6f4h3cck 470 14 the the DT cord-267475-6f4h3cck 470 15 idea idea NN cord-267475-6f4h3cck 470 16 that that IN cord-267475-6f4h3cck 470 17 the the DT cord-267475-6f4h3cck 470 18 duration duration NN cord-267475-6f4h3cck 470 19 of of IN cord-267475-6f4h3cck 470 20 the the DT cord-267475-6f4h3cck 470 21 elongation elongation NN cord-267475-6f4h3cck 470 22 phase phase NN cord-267475-6f4h3cck 470 23 matters matter VBZ cord-267475-6f4h3cck 470 24 : : : cord-267475-6f4h3cck 470 25 when when WRB cord-267475-6f4h3cck 470 26 a a DT cord-267475-6f4h3cck 470 27 short short JJ cord-267475-6f4h3cck 470 28 upORF uporf NN cord-267475-6f4h3cck 470 29 which which WDT cord-267475-6f4h3cck 470 30 normally normally RB cord-267475-6f4h3cck 470 31 permits permit VBZ cord-267475-6f4h3cck 470 32 reinitiation reinitiation NN cord-267475-6f4h3cck 470 33 was be VBD cord-267475-6f4h3cck 470 34 reconfigured reconfigure VBN cord-267475-6f4h3cck 470 35 to to TO cord-267475-6f4h3cck 470 36 contain contain VB cord-267475-6f4h3cck 470 37 a a DT cord-267475-6f4h3cck 470 38 pseudoknot pseudoknot NN cord-267475-6f4h3cck 470 39 that that WDT cord-267475-6f4h3cck 470 40 is be VBZ cord-267475-6f4h3cck 470 41 known know VBN cord-267475-6f4h3cck 470 42 to to TO cord-267475-6f4h3cck 470 43 slow slow VB cord-267475-6f4h3cck 470 44 elongation elongation NN cord-267475-6f4h3cck 470 45 , , , cord-267475-6f4h3cck 470 46 reinitiation reinitiation NN cord-267475-6f4h3cck 470 47 failed fail VBD cord-267475-6f4h3cck 470 48 ( ( -LRB- cord-267475-6f4h3cck 470 49 Kozak Kozak NNP cord-267475-6f4h3cck 470 50 , , , cord-267475-6f4h3cck 470 51 2001b 2001b CD cord-267475-6f4h3cck 470 52 ) ) -RRB- cord-267475-6f4h3cck 470 53 . . . cord-267475-6f4h3cck 471 1 That that DT cord-267475-6f4h3cck 471 2 result result NN cord-267475-6f4h3cck 471 3 makes make VBZ cord-267475-6f4h3cck 471 4 it -PRON- PRP cord-267475-6f4h3cck 471 5 difficult difficult JJ cord-267475-6f4h3cck 471 6 to to TO cord-267475-6f4h3cck 471 7 specify specify VB cord-267475-6f4h3cck 471 8 a a DT cord-267475-6f4h3cck 471 9 cutoff cutoff NN cord-267475-6f4h3cck 471 10 size size NN cord-267475-6f4h3cck 471 11 , , , cord-267475-6f4h3cck 471 12 i.e. i.e. FW cord-267475-6f4h3cck 471 13 one one PRP cord-267475-6f4h3cck 471 14 can can MD cord-267475-6f4h3cck 471 15 not not RB cord-267475-6f4h3cck 471 16 say say VB cord-267475-6f4h3cck 471 17 ' ' '' cord-267475-6f4h3cck 471 18 an an DT cord-267475-6f4h3cck 471 19 upORF uporf JJ cord-267475-6f4h3cck 471 20 this this DT cord-267475-6f4h3cck 471 21 long long JJ cord-267475-6f4h3cck 471 22 will will MD cord-267475-6f4h3cck 471 23 allow allow VB cord-267475-6f4h3cck 471 24 reinitiation reinitiation NN cord-267475-6f4h3cck 471 25 ' ' '' cord-267475-6f4h3cck 471 26 while while IN cord-267475-6f4h3cck 471 27 a a DT cord-267475-6f4h3cck 471 28 longer long JJR cord-267475-6f4h3cck 471 29 ORF ORF NNP cord-267475-6f4h3cck 471 30 will will MD cord-267475-6f4h3cck 471 31 not not RB cord-267475-6f4h3cck 471 32 . . . cord-267475-6f4h3cck 472 1 The the DT cord-267475-6f4h3cck 472 2 permissible permissible JJ cord-267475-6f4h3cck 472 3 size size NN cord-267475-6f4h3cck 472 4 is be VBZ cord-267475-6f4h3cck 472 5 likely likely JJ cord-267475-6f4h3cck 472 6 to to TO cord-267475-6f4h3cck 472 7 vary vary VB cord-267475-6f4h3cck 472 8 depending depend VBG cord-267475-6f4h3cck 472 9 on on IN cord-267475-6f4h3cck 472 10 features feature NNS cord-267475-6f4h3cck 472 11 , , , cord-267475-6f4h3cck 472 12 such such JJ cord-267475-6f4h3cck 472 13 as as IN cord-267475-6f4h3cck 472 14 secondary secondary JJ cord-267475-6f4h3cck 472 15 structure structure NN cord-267475-6f4h3cck 472 16 or or CC cord-267475-6f4h3cck 472 17 codon codon NN cord-267475-6f4h3cck 472 18 usage usage NN cord-267475-6f4h3cck 472 19 , , , cord-267475-6f4h3cck 472 20 that that WDT cord-267475-6f4h3cck 472 21 affect affect VBP cord-267475-6f4h3cck 472 22 the the DT cord-267475-6f4h3cck 472 23 rate rate NN cord-267475-6f4h3cck 472 24 of of IN cord-267475-6f4h3cck 472 25 elongation elongation NN cord-267475-6f4h3cck 472 26 . . . cord-267475-6f4h3cck 473 1 As as IN cord-267475-6f4h3cck 473 2 a a DT cord-267475-6f4h3cck 473 3 rough rough JJ cord-267475-6f4h3cck 473 4 guide guide NN cord-267475-6f4h3cck 473 5 , , , cord-267475-6f4h3cck 473 6 however however RB cord-267475-6f4h3cck 473 7 , , , cord-267475-6f4h3cck 473 8 one one PRP cord-267475-6f4h3cck 473 9 may may MD cord-267475-6f4h3cck 473 10 note note VB cord-267475-6f4h3cck 473 11 that that IN cord-267475-6f4h3cck 473 12 reinitiation reinitiation NN cord-267475-6f4h3cck 473 13 often often RB cord-267475-6f4h3cck 473 14 has have VBZ cord-267475-6f4h3cck 473 15 been be VBN cord-267475-6f4h3cck 473 16 observed observe VBN cord-267475-6f4h3cck 473 17 following follow VBG cord-267475-6f4h3cck 473 18 translation translation NN cord-267475-6f4h3cck 473 19 of of IN cord-267475-6f4h3cck 473 20 a a DT cord-267475-6f4h3cck 473 21 ten ten CD cord-267475-6f4h3cck 473 22 to to TO cord-267475-6f4h3cck 473 23 12 12 CD cord-267475-6f4h3cck 473 24 codon codon NN cord-267475-6f4h3cck 473 25 upORF uporf JJ cord-267475-6f4h3cck 473 26 , , , cord-267475-6f4h3cck 473 27 and and CC cord-267475-6f4h3cck 473 28 that that IN cord-267475-6f4h3cck 473 29 reinitiation reinitiation NN cord-267475-6f4h3cck 473 30 was be VBD cord-267475-6f4h3cck 473 31 substantially substantially RB cord-267475-6f4h3cck 473 32 reduced reduce VBN cord-267475-6f4h3cck 473 33 , , , cord-267475-6f4h3cck 473 34 but but CC cord-267475-6f4h3cck 473 35 not not RB cord-267475-6f4h3cck 473 36 abolished abolish VBN cord-267475-6f4h3cck 473 37 , , , cord-267475-6f4h3cck 473 38 when when WRB cord-267475-6f4h3cck 473 39 a a DT cord-267475-6f4h3cck 473 40 13 13 CD cord-267475-6f4h3cck 473 41 codon codon NN cord-267475-6f4h3cck 473 42 upORF upORF , cord-267475-6f4h3cck 473 43 was be VBD cord-267475-6f4h3cck 473 44 lengthened lengthen VBN cord-267475-6f4h3cck 473 45 to to IN cord-267475-6f4h3cck 473 46 33 33 CD cord-267475-6f4h3cck 473 47 codons codon NNS cord-267475-6f4h3cck 473 48 ( ( -LRB- cord-267475-6f4h3cck 473 49 Kozak Kozak NNP cord-267475-6f4h3cck 473 50 , , , cord-267475-6f4h3cck 473 51 2001b 2001b CD cord-267475-6f4h3cck 473 52 ) ) -RRB- cord-267475-6f4h3cck 473 53 . . . cord-267475-6f4h3cck 474 1 In in IN cord-267475-6f4h3cck 474 2 a a DT cord-267475-6f4h3cck 474 3 different different JJ cord-267475-6f4h3cck 474 4 study study NN cord-267475-6f4h3cck 474 5 , , , cord-267475-6f4h3cck 474 6 reinitiation reinitiation NN cord-267475-6f4h3cck 474 7 occurred occur VBD cord-267475-6f4h3cck 474 8 following follow VBG cord-267475-6f4h3cck 474 9 a a DT cord-267475-6f4h3cck 474 10 24 24 CD cord-267475-6f4h3cck 474 11 codon codon NN cord-267475-6f4h3cck 474 12 upORF upORF . cord-267475-6f4h3cck 475 1 but but CC cord-267475-6f4h3cck 475 2 not not RB cord-267475-6f4h3cck 475 3 when when WRB cord-267475-6f4h3cck 475 4 the the DT cord-267475-6f4h3cck 475 5 ORF ORF NNP cord-267475-6f4h3cck 475 6 was be VBD cord-267475-6f4h3cck 475 7 lengthened lengthen VBN cord-267475-6f4h3cck 475 8 to to IN cord-267475-6f4h3cck 475 9 40 40 CD cord-267475-6f4h3cck 475 10 codons codon NNS cord-267475-6f4h3cck 475 11 ( ( -LRB- cord-267475-6f4h3cck 475 12 Luukkonen Luukkonen NNP cord-267475-6f4h3cck 475 13 et et NNP cord-267475-6f4h3cck 475 14 al al NNP cord-267475-6f4h3cck 475 15 . . NNP cord-267475-6f4h3cck 475 16 , , , cord-267475-6f4h3cck 475 17 1995 1995 CD cord-267475-6f4h3cck 475 18 ) ) -RRB- cord-267475-6f4h3cck 475 19 . . . cord-267475-6f4h3cck 476 1 Some some DT cord-267475-6f4h3cck 476 2 naturally naturally RB cord-267475-6f4h3cck 476 3 occurring occur VBG cord-267475-6f4h3cck 476 4 upORFs uporfs RB cord-267475-6f4h3cck 477 1 that that WDT cord-267475-6f4h3cck 477 2 strongly strongly RB cord-267475-6f4h3cck 477 3 inhibit inhibit VBP cord-267475-6f4h3cck 477 4 translation translation NN cord-267475-6f4h3cck 477 5 , , , cord-267475-6f4h3cck 477 6 perhaps perhaps RB cord-267475-6f4h3cck 477 7 because because IN cord-267475-6f4h3cck 477 8 their -PRON- PRP$ cord-267475-6f4h3cck 477 9 size size NN cord-267475-6f4h3cck 477 10 precludes preclude VBZ cord-267475-6f4h3cck 477 11 reinitiation reinitiation NN cord-267475-6f4h3cck 477 12 , , , cord-267475-6f4h3cck 477 13 include include VBP cord-267475-6f4h3cck 477 14 a a DT cord-267475-6f4h3cck 477 15 36 36 CD cord-267475-6f4h3cck 477 16 codon codon NN cord-267475-6f4h3cck 477 17 upORF uporf JJ cord-267475-6f4h3cck 477 18 in in IN cord-267475-6f4h3cck 477 19 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 477 20 uncoupling uncouple VBG cord-267475-6f4h3cck 477 21 protein protein NN cord-267475-6f4h3cck 477 22 2 2 CD cord-267475-6f4h3cck 477 23 mRNA mrna NN cord-267475-6f4h3cck 477 24 ( ( -LRB- cord-267475-6f4h3cck 477 25 Pecqueur Pecqueur NNP cord-267475-6f4h3cck 477 26 et et NNP cord-267475-6f4h3cck 477 27 al al NNP cord-267475-6f4h3cck 477 28 . . NNP cord-267475-6f4h3cck 477 29 , , , cord-267475-6f4h3cck 477 30 2001 2001 CD cord-267475-6f4h3cck 477 31 ) ) -RRB- cord-267475-6f4h3cck 477 32 , , , cord-267475-6f4h3cck 477 33 a a DT cord-267475-6f4h3cck 477 34 71 71 CD cord-267475-6f4h3cck 477 35 codon codon NN cord-267475-6f4h3cck 477 36 upORF uporf JJ cord-267475-6f4h3cck 477 37 in in IN cord-267475-6f4h3cck 477 38 polyoma polyoma NNP cord-267475-6f4h3cck 477 39 virus virus NN cord-267475-6f4h3cck 477 40 JC JC NNP cord-267475-6f4h3cck 477 41 mRNA mRNA NNP cord-267475-6f4h3cck 478 1 ( ( -LRB- cord-267475-6f4h3cck 478 2 Shishido Shishido NNP cord-267475-6f4h3cck 478 3 - - HYPH cord-267475-6f4h3cck 478 4 Hara Hara NNP cord-267475-6f4h3cck 478 5 et et NNP cord-267475-6f4h3cck 478 6 al al NNP cord-267475-6f4h3cck 478 7 . . NNP cord-267475-6f4h3cck 478 8 , , , cord-267475-6f4h3cck 478 9 2000 2000 CD cord-267475-6f4h3cck 478 10 ) ) -RRB- cord-267475-6f4h3cck 478 11 , , , cord-267475-6f4h3cck 478 12 and and CC cord-267475-6f4h3cck 478 13 a a DT cord-267475-6f4h3cck 478 14 53 53 CD cord-267475-6f4h3cck 478 15 codon codon NN cord-267475-6f4h3cck 478 16 upORF uporf JJ cord-267475-6f4h3cck 478 17 in in IN cord-267475-6f4h3cck 478 18 plant plant NN cord-267475-6f4h3cck 478 19 S S NNP cord-267475-6f4h3cck 478 20 - - HYPH cord-267475-6f4h3cck 478 21 adenosylmethionine adenosylmethionine NNP cord-267475-6f4h3cck 478 22 decarboxylase decarboxylase NN cord-267475-6f4h3cck 478 23 ( ( -LRB- cord-267475-6f4h3cck 478 24 AdoMetDC AdoMetDC NNP cord-267475-6f4h3cck 478 25 ) ) -RRB- cord-267475-6f4h3cck 479 1 mRNA mRNA NNP cord-267475-6f4h3cck 480 1 ( ( -LRB- cord-267475-6f4h3cck 480 2 Hanfrey Hanfrey NNP cord-267475-6f4h3cck 480 3 et et NNP cord-267475-6f4h3cck 480 4 al al NNP cord-267475-6f4h3cck 480 5 . . NNP cord-267475-6f4h3cck 480 6 , , , cord-267475-6f4h3cck 480 7 in in IN cord-267475-6f4h3cck 480 8 press press NN cord-267475-6f4h3cck 480 9 ) ) -RRB- cord-267475-6f4h3cck 480 10 . . . cord-267475-6f4h3cck 481 1 That that IN cord-267475-6f4h3cck 481 2 the the DT cord-267475-6f4h3cck 481 3 size size NN cord-267475-6f4h3cck 481 4 of of IN cord-267475-6f4h3cck 481 5 the the DT cord-267475-6f4h3cck 481 6 upORF upORF NNP cord-267475-6f4h3cck 481 7 might may MD cord-267475-6f4h3cck 481 8 be be VB cord-267475-6f4h3cck 481 9 what what WP cord-267475-6f4h3cck 481 10 limits limit VBZ cord-267475-6f4h3cck 481 11 translation translation NN cord-267475-6f4h3cck 481 12 of of IN cord-267475-6f4h3cck 481 13 AdoMetDC AdoMetDC NNP cord-267475-6f4h3cck 481 14 is be VBZ cord-267475-6f4h3cck 481 15 suggested suggest VBN cord-267475-6f4h3cck 481 16 from from IN cord-267475-6f4h3cck 481 17 the the DT cord-267475-6f4h3cck 481 18 five five CD cord-267475-6f4h3cck 481 19 - - JJ cord-267475-6f4h3cck 481 20 fold fold JJ cord-267475-6f4h3cck 481 21 increase increase NN cord-267475-6f4h3cck 481 22 in in IN cord-267475-6f4h3cck 481 23 translation translation NN cord-267475-6f4h3cck 481 24 observed observe VBD cord-267475-6f4h3cck 481 25 when when WRB cord-267475-6f4h3cck 481 26 the the DT cord-267475-6f4h3cck 481 27 upORF uporf JJ cord-267475-6f4h3cck 481 28 was be VBD cord-267475-6f4h3cck 481 29 shortened shorten VBN cord-267475-6f4h3cck 481 30 from from IN cord-267475-6f4h3cck 481 31 53 53 CD cord-267475-6f4h3cck 481 32 to to TO cord-267475-6f4h3cck 481 33 25 25 CD cord-267475-6f4h3cck 481 34 codons codon NNS cord-267475-6f4h3cck 481 35 , , , cord-267475-6f4h3cck 481 36 but but CC cord-267475-6f4h3cck 481 37 that that DT cord-267475-6f4h3cck 481 38 result result NN cord-267475-6f4h3cck 481 39 could could MD cord-267475-6f4h3cck 481 40 also also RB cord-267475-6f4h3cck 481 41 be be VB cord-267475-6f4h3cck 481 42 explained explain VBN cord-267475-6f4h3cck 481 43 in in IN cord-267475-6f4h3cck 481 44 other other JJ cord-267475-6f4h3cck 481 45 ways way NNS cord-267475-6f4h3cck 481 46 . . . cord-267475-6f4h3cck 482 1 ( ( -LRB- cord-267475-6f4h3cck 482 2 The the DT cord-267475-6f4h3cck 482 3 suggested suggested JJ cord-267475-6f4h3cck 482 4 interpretation interpretation NN cord-267475-6f4h3cck 482 5 is be VBZ cord-267475-6f4h3cck 482 6 not not RB cord-267475-6f4h3cck 482 7 contradicted contradict VBN cord-267475-6f4h3cck 482 8 by by IN cord-267475-6f4h3cck 482 9 the the DT cord-267475-6f4h3cck 482 10 fact fact NN cord-267475-6f4h3cck 482 11 that that IN cord-267475-6f4h3cck 482 12 an an DT cord-267475-6f4h3cck 482 13 alternative alternative NN cord-267475-6f4h3cck 482 14 upORF uporf NN cord-267475-6f4h3cck 482 15 in in IN cord-267475-6f4h3cck 482 16 AdoMetDC AdoMetDC NNP cord-267475-6f4h3cck 482 17 mRNA mrna NN cord-267475-6f4h3cck 482 18 caused cause VBD cord-267475-6f4h3cck 482 19 little little JJ cord-267475-6f4h3cck 482 20 inhibition inhibition NN cord-267475-6f4h3cck 482 21 even even RB cord-267475-6f4h3cck 482 22 when when WRB cord-267475-6f4h3cck 482 23 lengthened lengthen VBD cord-267475-6f4h3cck 482 24 to to IN cord-267475-6f4h3cck 482 25 66 66 CD cord-267475-6f4h3cck 482 26 codons codon NNS cord-267475-6f4h3cck 482 27 ; ; : cord-267475-6f4h3cck 482 28 the the DT cord-267475-6f4h3cck 482 29 alternative alternative NN cord-267475-6f4h3cck 482 30 upORF uporf NN cord-267475-6f4h3cck 482 31 initiates initiate VBZ cord-267475-6f4h3cck 482 32 from from IN cord-267475-6f4h3cck 482 33 an an DT cord-267475-6f4h3cck 482 34 AUG AUG NNP cord-267475-6f4h3cck 482 35 codon codon NN cord-267475-6f4h3cck 482 36 in in IN cord-267475-6f4h3cck 482 37 a a DT cord-267475-6f4h3cck 482 38 weak weak JJ cord-267475-6f4h3cck 482 39 context context NN cord-267475-6f4h3cck 482 40 which which WDT cord-267475-6f4h3cck 482 41 would would MD cord-267475-6f4h3cck 482 42 allow allow VB cord-267475-6f4h3cck 482 43 it -PRON- PRP cord-267475-6f4h3cck 482 44 to to TO cord-267475-6f4h3cck 482 45 be be VB cord-267475-6f4h3cck 482 46 bypassed bypass VBN cord-267475-6f4h3cck 482 47 to to IN cord-267475-6f4h3cck 482 48 some some DT cord-267475-6f4h3cck 482 49 extent extent NN cord-267475-6f4h3cck 482 50 by by IN cord-267475-6f4h3cck 482 51 leaky leaky JJ cord-267475-6f4h3cck 482 52 scanning scanning NN cord-267475-6f4h3cck 482 53 . . . cord-267475-6f4h3cck 483 1 The the DT cord-267475-6f4h3cck 483 2 53 53 CD cord-267475-6f4h3cck 483 3 codon codon NN cord-267475-6f4h3cck 483 4 upORF uporf JJ cord-267475-6f4h3cck 483 5 , , , cord-267475-6f4h3cck 483 6 in in IN cord-267475-6f4h3cck 483 7 contrast contrast NN cord-267475-6f4h3cck 483 8 , , , cord-267475-6f4h3cck 483 9 has have VBZ cord-267475-6f4h3cck 483 10 a a DT cord-267475-6f4h3cck 483 11 strong strong JJ cord-267475-6f4h3cck 483 12 start start NN cord-267475-6f4h3cck 483 13 codon codon NN cord-267475-6f4h3cck 483 14 . . . cord-267475-6f4h3cck 483 15 ) ) -RRB- cord-267475-6f4h3cck 484 1 With with IN cord-267475-6f4h3cck 484 2 the the DT cord-267475-6f4h3cck 484 3 mouse mouse NN cord-267475-6f4h3cck 484 4 Snurf Snurf NNP cord-267475-6f4h3cck 484 5 - - HYPH cord-267475-6f4h3cck 484 6 Snrpn Snrpn NNP cord-267475-6f4h3cck 484 7 transcript transcript NN cord-267475-6f4h3cck 484 8 , , , cord-267475-6f4h3cck 484 9 where where WRB cord-267475-6f4h3cck 484 10 the the DT cord-267475-6f4h3cck 484 11 first first JJ cord-267475-6f4h3cck 484 12 cistron cistron NN cord-267475-6f4h3cck 484 13 is be VBZ cord-267475-6f4h3cck 484 14 71 71 CD cord-267475-6f4h3cck 484 15 codons codon NNS cord-267475-6f4h3cck 484 16 long long JJ cord-267475-6f4h3cck 484 17 , , , cord-267475-6f4h3cck 484 18 a a DT cord-267475-6f4h3cck 484 19 very very RB cord-267475-6f4h3cck 484 20 low low JJ cord-267475-6f4h3cck 484 21 level level NN cord-267475-6f4h3cck 484 22 of of IN cord-267475-6f4h3cck 484 23 reinitiation reinitiation NN cord-267475-6f4h3cck 484 24 might may MD cord-267475-6f4h3cck 484 25 account account VB cord-267475-6f4h3cck 484 26 for for IN cord-267475-6f4h3cck 484 27 translation translation NN cord-267475-6f4h3cck 484 28 of of IN cord-267475-6f4h3cck 484 29 the the DT cord-267475-6f4h3cck 484 30 downstream downstream JJ cord-267475-6f4h3cck 484 31 SNRPN SNRPN NNP cord-267475-6f4h3cck 484 32 cistron cistron NN cord-267475-6f4h3cck 484 33 . . . cord-267475-6f4h3cck 485 1 A a DT cord-267475-6f4h3cck 485 2 naturally naturally RB cord-267475-6f4h3cck 485 3 occurring occur VBG cord-267475-6f4h3cck 485 4 ATG ATG NNP cord-267475-6f4h3cck 485 5 - - HYPH cord-267475-6f4h3cck 485 6 to to IN cord-267475-6f4h3cck 485 7 - - HYPH cord-267475-6f4h3cck 485 8 AGG agg NN cord-267475-6f4h3cck 485 9 mutation mutation NN cord-267475-6f4h3cck 485 10 in in IN cord-267475-6f4h3cck 485 11 the the DT cord-267475-6f4h3cck 485 12 start start NN cord-267475-6f4h3cck 485 13 codon codon NN cord-267475-6f4h3cck 485 14 of of IN cord-267475-6f4h3cck 485 15 the the DT cord-267475-6f4h3cck 485 16 upstream upstream JJ cord-267475-6f4h3cck 485 17 SNURF SNURF NNP cord-267475-6f4h3cck 485 18 cistron cistron NNP cord-267475-6f4h3cck 485 19 was be VBD cord-267475-6f4h3cck 485 20 found find VBN cord-267475-6f4h3cck 485 21 to to TO cord-267475-6f4h3cck 485 22 elevate elevate VB cord-267475-6f4h3cck 485 23 translation translation NN cord-267475-6f4h3cck 485 24 of of IN cord-267475-6f4h3cck 485 25 SNRPN SNRPN NNP cord-267475-6f4h3cck 485 26 . . . cord-267475-6f4h3cck 486 1 15fold 15fold LS cord-267475-6f4h3cck 487 1 ( ( -LRB- cord-267475-6f4h3cck 487 2 Tsai Tsai NNP cord-267475-6f4h3cck 487 3 et et NNP cord-267475-6f4h3cck 487 4 al al NNP cord-267475-6f4h3cck 487 5 . . NNP cord-267475-6f4h3cck 487 6 , , , cord-267475-6f4h3cck 487 7 2002 2002 CD cord-267475-6f4h3cck 487 8 ) ) -RRB- cord-267475-6f4h3cck 487 9 , , , cord-267475-6f4h3cck 487 10 which which WDT cord-267475-6f4h3cck 487 11 implicates implicate VBZ cord-267475-6f4h3cck 487 12 a a DT cord-267475-6f4h3cck 487 13 scanning/ scanning/ NN cord-267475-6f4h3cck 487 14 reinitiation reinitiation NN cord-267475-6f4h3cck 487 15 mechanism mechanism NN cord-267475-6f4h3cck 487 16 and and CC cord-267475-6f4h3cck 487 17 rules rule VBZ cord-267475-6f4h3cck 487 18 out out RP cord-267475-6f4h3cck 487 19 direct direct JJ cord-267475-6f4h3cck 487 20 internal internal JJ cord-267475-6f4h3cck 487 21 initiation initiation NN cord-267475-6f4h3cck 487 22 . . . cord-267475-6f4h3cck 488 1 From from IN cord-267475-6f4h3cck 488 2 cDNA cdna NN cord-267475-6f4h3cck 488 3 sequencing sequencing NN cord-267475-6f4h3cck 488 4 data datum NNS cord-267475-6f4h3cck 488 5 , , , cord-267475-6f4h3cck 488 6 it -PRON- PRP cord-267475-6f4h3cck 488 7 is be VBZ cord-267475-6f4h3cck 488 8 clear clear JJ cord-267475-6f4h3cck 488 9 that that IN cord-267475-6f4h3cck 488 10 many many JJ cord-267475-6f4h3cck 488 11 vertebrate vertebrate NN cord-267475-6f4h3cck 488 12 mRNAs mRNAs NNPS cord-267475-6f4h3cck 488 13 have have VBP cord-267475-6f4h3cck 488 14 small small JJ cord-267475-6f4h3cck 488 15 ORFs orfs NN cord-267475-6f4h3cck 488 16 upstream upstream RB cord-267475-6f4h3cck 488 17 from from IN cord-267475-6f4h3cck 488 18 the the DT cord-267475-6f4h3cck 488 19 start start NN cord-267475-6f4h3cck 488 20 of of IN cord-267475-6f4h3cck 488 21 the the DT cord-267475-6f4h3cck 488 22 major major JJ cord-267475-6f4h3cck 488 23 coding coding NN cord-267475-6f4h3cck 488 24 domain domain NN cord-267475-6f4h3cck 488 25 , , , cord-267475-6f4h3cck 488 26 but but CC cord-267475-6f4h3cck 488 27 an an DT cord-267475-6f4h3cck 488 28 accurate accurate JJ cord-267475-6f4h3cck 488 29 count count NN cord-267475-6f4h3cck 488 30 of of IN cord-267475-6f4h3cck 488 31 genes gene NNS cord-267475-6f4h3cck 488 32 in in IN cord-267475-6f4h3cck 488 33 this this DT cord-267475-6f4h3cck 488 34 class class NN cord-267475-6f4h3cck 488 35 is be VBZ cord-267475-6f4h3cck 488 36 difficult difficult JJ cord-267475-6f4h3cck 488 37 . . . cord-267475-6f4h3cck 489 1 The the DT cord-267475-6f4h3cck 489 2 tallies tally NNS cord-267475-6f4h3cck 489 3 that that WDT cord-267475-6f4h3cck 489 4 have have VBP cord-267475-6f4h3cck 489 5 been be VBN cord-267475-6f4h3cck 489 6 attempted attempt VBN cord-267475-6f4h3cck 489 7 ( ( -LRB- cord-267475-6f4h3cck 489 8 e.g. e.g. RB cord-267475-6f4h3cck 489 9 Pesole Pesole NNP cord-267475-6f4h3cck 489 10 et et NNP cord-267475-6f4h3cck 489 11 al al NNP cord-267475-6f4h3cck 489 12 . . NNP cord-267475-6f4h3cck 489 13 , , , cord-267475-6f4h3cck 489 14 2001 2001 CD cord-267475-6f4h3cck 489 15 ; ; : cord-267475-6f4h3cck 489 16 Suzuki Suzuki NNP cord-267475-6f4h3cck 489 17 et et NNP cord-267475-6f4h3cck 489 18 al al NNP cord-267475-6f4h3cck 489 19 . . NNP cord-267475-6f4h3cck 489 20 , , , cord-267475-6f4h3cck 489 21 2000 2000 CD cord-267475-6f4h3cck 489 22 ) ) -RRB- cord-267475-6f4h3cck 489 23 are be VBP cord-267475-6f4h3cck 489 24 invariably invariably RB cord-267475-6f4h3cck 489 25 flawed flaw VBN cord-267475-6f4h3cck 489 26 by by IN cord-267475-6f4h3cck 489 27 inclusion inclusion NN cord-267475-6f4h3cck 489 28 of of IN cord-267475-6f4h3cck 489 29 misinterpreted misinterpret VBN cord-267475-6f4h3cck 489 30 cDNA cdna NN cord-267475-6f4h3cck 489 31 sequences sequence NNS cord-267475-6f4h3cck 489 32 , , , cord-267475-6f4h3cck 489 33 such such JJ cord-267475-6f4h3cck 489 34 as as IN cord-267475-6f4h3cck 489 35 cDNAs cDNAs NNPS cord-267475-6f4h3cck 489 36 in in IN cord-267475-6f4h3cck 489 37 which which WDT cord-267475-6f4h3cck 489 38 a a DT cord-267475-6f4h3cck 489 39 putative putative JJ cord-267475-6f4h3cck 489 40 5 5 CD cord-267475-6f4h3cck 489 41 0 0 CD cord-267475-6f4h3cck 489 42 UTR UTR NNP cord-267475-6f4h3cck 489 43 with with IN cord-267475-6f4h3cck 489 44 ' ' `` cord-267475-6f4h3cck 489 45 upstream upstream RB cord-267475-6f4h3cck 489 46 ' ' '' cord-267475-6f4h3cck 489 47 AUG AUG NNP cord-267475-6f4h3cck 489 48 codons codon NNS cord-267475-6f4h3cck 489 49 turned turn VBD cord-267475-6f4h3cck 489 50 out out RP cord-267475-6f4h3cck 489 51 to to TO cord-267475-6f4h3cck 489 52 be be VB cord-267475-6f4h3cck 489 53 part part NN cord-267475-6f4h3cck 489 54 of of IN cord-267475-6f4h3cck 489 55 the the DT cord-267475-6f4h3cck 489 56 coding code VBG cord-267475-6f4h3cck 489 57 domain domain NN cord-267475-6f4h3cck 489 58 or or CC cord-267475-6f4h3cck 489 59 part part NN cord-267475-6f4h3cck 489 60 of of IN cord-267475-6f4h3cck 489 61 an an DT cord-267475-6f4h3cck 489 62 intron intron NN cord-267475-6f4h3cck 489 63 that that WDT cord-267475-6f4h3cck 489 64 gets get VBZ cord-267475-6f4h3cck 489 65 removed remove VBN cord-267475-6f4h3cck 489 66 from from IN cord-267475-6f4h3cck 489 67 the the DT cord-267475-6f4h3cck 489 68 functional functional JJ cord-267475-6f4h3cck 489 69 mRNA mrna NN cord-267475-6f4h3cck 489 70 ( ( -LRB- cord-267475-6f4h3cck 489 71 Di Di NNP cord-267475-6f4h3cck 489 72 Fruscio Fruscio NNP cord-267475-6f4h3cck 489 73 et et NNP cord-267475-6f4h3cck 489 74 al al NNP cord-267475-6f4h3cck 489 75 . . NNP cord-267475-6f4h3cck 489 76 , , , cord-267475-6f4h3cck 489 77 1998 1998 CD cord-267475-6f4h3cck 489 78 ; ; : cord-267475-6f4h3cck 489 79 Kozak Kozak NNP cord-267475-6f4h3cck 489 80 , , , cord-267475-6f4h3cck 489 81 1996 1996 CD cord-267475-6f4h3cck 489 82 Kozak Kozak NNP cord-267475-6f4h3cck 489 83 , , , cord-267475-6f4h3cck 489 84 , , , cord-267475-6f4h3cck 489 85 2000 2000 CD cord-267475-6f4h3cck 490 1 Kubu Kubu NNP cord-267475-6f4h3cck 490 2 et et NNP cord-267475-6f4h3cck 490 3 al al NNP cord-267475-6f4h3cck 490 4 . . NNP cord-267475-6f4h3cck 490 5 , , , cord-267475-6f4h3cck 490 6 2000 2000 CD cord-267475-6f4h3cck 491 1 ; ; : cord-267475-6f4h3cck 491 2 Nishitani Nishitani NNP cord-267475-6f4h3cck 491 3 et et NNP cord-267475-6f4h3cck 491 4 al al NNP cord-267475-6f4h3cck 491 5 . . NNP cord-267475-6f4h3cck 491 6 , , , cord-267475-6f4h3cck 491 7 2001 2001 CD cord-267475-6f4h3cck 491 8 ; ; : cord-267475-6f4h3cck 491 9 Santamarina Santamarina NNP cord-267475-6f4h3cck 491 10 - - HYPH cord-267475-6f4h3cck 491 11 Fojo Fojo NNP cord-267475-6f4h3cck 491 12 et et NNP cord-267475-6f4h3cck 491 13 al al NNP cord-267475-6f4h3cck 491 14 . . NNP cord-267475-6f4h3cck 491 15 , , , cord-267475-6f4h3cck 491 16 2000 2000 CD cord-267475-6f4h3cck 492 1 ; ; : cord-267475-6f4h3cck 492 2 Wagner Wagner NNP cord-267475-6f4h3cck 492 3 et et NNP cord-267475-6f4h3cck 492 4 al al NNP cord-267475-6f4h3cck 492 5 . . NNP cord-267475-6f4h3cck 492 6 , , , cord-267475-6f4h3cck 492 7 1998 1998 CD cord-267475-6f4h3cck 492 8 ) ) -RRB- cord-267475-6f4h3cck 492 9 . . . cord-267475-6f4h3cck 493 1 Some some DT cord-267475-6f4h3cck 493 2 transcripts transcript NNS cord-267475-6f4h3cck 493 3 with with IN cord-267475-6f4h3cck 493 4 long long RB cord-267475-6f4h3cck 493 5 , , , cord-267475-6f4h3cck 493 6 AUG AUG NNP cord-267475-6f4h3cck 493 7 - - HYPH cord-267475-6f4h3cck 493 8 burdened burden VBN cord-267475-6f4h3cck 493 9 leader leader NN cord-267475-6f4h3cck 493 10 sequences sequence NNS cord-267475-6f4h3cck 493 11 are be VBP cord-267475-6f4h3cck 493 12 not not RB cord-267475-6f4h3cck 493 13 associated associate VBN cord-267475-6f4h3cck 493 14 with with IN cord-267475-6f4h3cck 493 15 polysomes polysome NNS cord-267475-6f4h3cck 493 16 ( ( -LRB- cord-267475-6f4h3cck 493 17 Hake Hake NNP cord-267475-6f4h3cck 493 18 and and CC cord-267475-6f4h3cck 493 19 Hecht Hecht NNP cord-267475-6f4h3cck 493 20 , , , cord-267475-6f4h3cck 493 21 1993 1993 CD cord-267475-6f4h3cck 493 22 ; ; : cord-267475-6f4h3cck 493 23 Sanchez Sanchez NNP cord-267475-6f4h3cck 493 24 - - HYPH cord-267475-6f4h3cck 493 25 Góngora Góngora NNP cord-267475-6f4h3cck 493 26 et et FW cord-267475-6f4h3cck 493 27 al al NNP cord-267475-6f4h3cck 493 28 . . NNP cord-267475-6f4h3cck 493 29 , , , cord-267475-6f4h3cck 493 30 2000 2000 CD cord-267475-6f4h3cck 493 31 ) ) -RRB- cord-267475-6f4h3cck 493 32 or or CC cord-267475-6f4h3cck 493 33 not not RB cord-267475-6f4h3cck 493 34 able able JJ cord-267475-6f4h3cck 493 35 to to TO cord-267475-6f4h3cck 493 36 support support VB cord-267475-6f4h3cck 493 37 protein protein NN cord-267475-6f4h3cck 493 38 synthesis synthesis NN cord-267475-6f4h3cck 493 39 ( ( -LRB- cord-267475-6f4h3cck 494 1 Foo Foo NNP cord-267475-6f4h3cck 494 2 et et NNP cord-267475-6f4h3cck 494 3 al al NNP cord-267475-6f4h3cck 494 4 . . . cord-267475-6f4h3cck 495 1 , , , cord-267475-6f4h3cck 495 2 1994 1994 CD cord-267475-6f4h3cck 495 3 ; ; : cord-267475-6f4h3cck 495 4 Larsen Larsen NNP cord-267475-6f4h3cck 495 5 et et NNP cord-267475-6f4h3cck 495 6 al al NNP cord-267475-6f4h3cck 495 7 . . NNP cord-267475-6f4h3cck 495 8 , , , cord-267475-6f4h3cck 495 9 2002 2002 CD cord-267475-6f4h3cck 496 1 ; ; : cord-267475-6f4h3cck 496 2 Lee Lee NNP cord-267475-6f4h3cck 496 3 et et NNP cord-267475-6f4h3cck 496 4 al al NNP cord-267475-6f4h3cck 496 5 . . NNP cord-267475-6f4h3cck 496 6 , , , cord-267475-6f4h3cck 496 7 2000 2000 CD cord-267475-6f4h3cck 496 8 ) ) -RRB- cord-267475-6f4h3cck 496 9 , , , cord-267475-6f4h3cck 496 10 emphasizing emphasize VBG cord-267475-6f4h3cck 496 11 that that IN cord-267475-6f4h3cck 496 12 not not RB cord-267475-6f4h3cck 496 13 all all DT cord-267475-6f4h3cck 496 14 cDNAs cdnas ADD cord-267475-6f4h3cck 496 15 correspond correspond VBP cord-267475-6f4h3cck 496 16 to to IN cord-267475-6f4h3cck 496 17 functional functional JJ cord-267475-6f4h3cck 496 18 mRNAs mrna NNS cord-267475-6f4h3cck 496 19 . . . cord-267475-6f4h3cck 497 1 A a DT cord-267475-6f4h3cck 497 2 more more RBR cord-267475-6f4h3cck 497 3 fundamental fundamental JJ cord-267475-6f4h3cck 497 4 complication complication NN cord-267475-6f4h3cck 497 5 vis vis FW cord-267475-6f4h3cck 497 6 - - HYPH cord-267475-6f4h3cck 497 7 à à FW cord-267475-6f4h3cck 497 8 - - HYPH cord-267475-6f4h3cck 497 9 vis vis FW cord-267475-6f4h3cck 497 10 which which WDT cord-267475-6f4h3cck 497 11 genes gene VBZ cord-267475-6f4h3cck 497 12 to to TO cord-267475-6f4h3cck 497 13 count count VB cord-267475-6f4h3cck 497 14 is be VBZ cord-267475-6f4h3cck 497 15 the the DT cord-267475-6f4h3cck 497 16 propensity propensity NN cord-267475-6f4h3cck 497 17 for for IN cord-267475-6f4h3cck 497 18 a a DT cord-267475-6f4h3cck 497 19 single single JJ cord-267475-6f4h3cck 497 20 gene gene NN cord-267475-6f4h3cck 497 21 to to TO cord-267475-6f4h3cck 497 22 produce produce VB cord-267475-6f4h3cck 497 23 transcripts transcript NNS cord-267475-6f4h3cck 497 24 with with IN cord-267475-6f4h3cck 497 25 different different JJ cord-267475-6f4h3cck 497 26 5 5 CD cord-267475-6f4h3cck 497 27 0 0 CD cord-267475-6f4h3cck 497 28 leader leader NN cord-267475-6f4h3cck 497 29 sequences sequence NNS cord-267475-6f4h3cck 497 30 , , , cord-267475-6f4h3cck 497 31 only only RB cord-267475-6f4h3cck 497 32 some some DT cord-267475-6f4h3cck 497 33 of of IN cord-267475-6f4h3cck 497 34 which which WDT cord-267475-6f4h3cck 497 35 have have VBP cord-267475-6f4h3cck 497 36 upstream upstream JJ cord-267475-6f4h3cck 497 37 AUG AUG NNP cord-267475-6f4h3cck 497 38 codons codon NNS cord-267475-6f4h3cck 497 39 ( ( -LRB- cord-267475-6f4h3cck 497 40 Anant Anant NNP cord-267475-6f4h3cck 497 41 et et NNP cord-267475-6f4h3cck 497 42 al al NNP cord-267475-6f4h3cck 497 43 . . NNP cord-267475-6f4h3cck 497 44 , , , cord-267475-6f4h3cck 497 45 2002 2002 CD cord-267475-6f4h3cck 497 46 ; ; : cord-267475-6f4h3cck 497 47 Aplan Aplan NNP cord-267475-6f4h3cck 497 48 et et NNP cord-267475-6f4h3cck 497 49 al al NNP cord-267475-6f4h3cck 497 50 . . NNP cord-267475-6f4h3cck 497 51 , , , cord-267475-6f4h3cck 497 52 1991 1991 CD cord-267475-6f4h3cck 497 53 ; ; : cord-267475-6f4h3cck 497 54 Eerola Eerola NNP cord-267475-6f4h3cck 497 55 et et NNP cord-267475-6f4h3cck 497 56 al al NNP cord-267475-6f4h3cck 497 57 . . NNP cord-267475-6f4h3cck 497 58 , , , cord-267475-6f4h3cck 497 59 2001 2001 CD cord-267475-6f4h3cck 497 60 ; ; : cord-267475-6f4h3cck 497 61 Huo Huo NNP cord-267475-6f4h3cck 497 62 and and CC cord-267475-6f4h3cck 497 63 Scarpulla Scarpulla NNP cord-267475-6f4h3cck 497 64 , , , cord-267475-6f4h3cck 497 65 1999 1999 CD cord-267475-6f4h3cck 497 66 ; ; : cord-267475-6f4h3cck 497 67 Kawakubo Kawakubo NNP cord-267475-6f4h3cck 497 68 and and CC cord-267475-6f4h3cck 497 69 Samuel Samuel NNP cord-267475-6f4h3cck 497 70 , , , cord-267475-6f4h3cck 497 71 2000 2000 CD cord-267475-6f4h3cck 497 72 ; ; : cord-267475-6f4h3cck 497 73 Laurin Laurin NNP cord-267475-6f4h3cck 497 74 et et NNP cord-267475-6f4h3cck 497 75 al al NNP cord-267475-6f4h3cck 497 76 . . NNP cord-267475-6f4h3cck 497 77 , , , cord-267475-6f4h3cck 497 78 2000 2000 CD cord-267475-6f4h3cck 497 79 ; ; : cord-267475-6f4h3cck 497 80 Perälä Perälä NNP cord-267475-6f4h3cck 497 81 et et NNP cord-267475-6f4h3cck 497 82 al al NNP cord-267475-6f4h3cck 497 83 . . NNP cord-267475-6f4h3cck 497 84 , , , cord-267475-6f4h3cck 497 85 1994 1994 CD cord-267475-6f4h3cck 497 86 ; ; : cord-267475-6f4h3cck 497 87 Perrais Perrais NNP cord-267475-6f4h3cck 497 88 et et NNP cord-267475-6f4h3cck 497 89 al al NNP cord-267475-6f4h3cck 497 90 . . NNP cord-267475-6f4h3cck 497 91 , , , cord-267475-6f4h3cck 497 92 2001 2001 CD cord-267475-6f4h3cck 497 93 ; ; : cord-267475-6f4h3cck 497 94 Sanchez Sanchez NNP cord-267475-6f4h3cck 497 95 - - HYPH cord-267475-6f4h3cck 497 96 Góngora Góngora NNP cord-267475-6f4h3cck 497 97 et et FW cord-267475-6f4h3cck 497 98 al al NNP cord-267475-6f4h3cck 497 99 . . NNP cord-267475-6f4h3cck 497 100 , , , cord-267475-6f4h3cck 497 101 2000 2000 CD cord-267475-6f4h3cck 497 102 ; ; : cord-267475-6f4h3cck 497 103 Suva Suva NNP cord-267475-6f4h3cck 497 104 et et NNP cord-267475-6f4h3cck 497 105 al al NNP cord-267475-6f4h3cck 497 106 . . NNP cord-267475-6f4h3cck 497 107 , , , cord-267475-6f4h3cck 497 108 1989 1989 CD cord-267475-6f4h3cck 497 109 ; ; : cord-267475-6f4h3cck 497 110 Tanaka Tanaka NNP cord-267475-6f4h3cck 497 111 et et NNP cord-267475-6f4h3cck 497 112 al al NNP cord-267475-6f4h3cck 497 113 . . NNP cord-267475-6f4h3cck 497 114 , , , cord-267475-6f4h3cck 497 115 2001 2001 CD cord-267475-6f4h3cck 497 116 ; ; : cord-267475-6f4h3cck 497 117 Tsuda Tsuda NNP cord-267475-6f4h3cck 497 118 et et FW cord-267475-6f4h3cck 497 119 al al NNP cord-267475-6f4h3cck 497 120 . . NNP cord-267475-6f4h3cck 497 121 , , , cord-267475-6f4h3cck 497 122 2000 2000 CD cord-267475-6f4h3cck 497 123 ; ; : cord-267475-6f4h3cck 497 124 Zimmermann Zimmermann NNP cord-267475-6f4h3cck 497 125 et et NNP cord-267475-6f4h3cck 497 126 al al NNP cord-267475-6f4h3cck 497 127 . . NNP cord-267475-6f4h3cck 497 128 , , , cord-267475-6f4h3cck 497 129 2000 2000 CD cord-267475-6f4h3cck 497 130 ) ) -RRB- cord-267475-6f4h3cck 497 131 . . . cord-267475-6f4h3cck 498 1 The the DT cord-267475-6f4h3cck 498 2 significance significance NN cord-267475-6f4h3cck 498 3 of of IN cord-267475-6f4h3cck 498 4 a a DT cord-267475-6f4h3cck 498 5 particular particular JJ cord-267475-6f4h3cck 498 6 form form NN cord-267475-6f4h3cck 498 7 of of IN cord-267475-6f4h3cck 498 8 RNA RNA NNP cord-267475-6f4h3cck 498 9 can can MD cord-267475-6f4h3cck 498 10 not not RB cord-267475-6f4h3cck 498 11 always always RB cord-267475-6f4h3cck 498 12 be be VB cord-267475-6f4h3cck 498 13 deduced deduce VBN cord-267475-6f4h3cck 498 14 from from IN cord-267475-6f4h3cck 498 15 its -PRON- PRP$ cord-267475-6f4h3cck 498 16 abundance abundance NN cord-267475-6f4h3cck 498 17 , , , cord-267475-6f4h3cck 498 18 inasmuch inasmuch RB cord-267475-6f4h3cck 498 19 as as IN cord-267475-6f4h3cck 498 20 a a DT cord-267475-6f4h3cck 498 21 minor minor JJ cord-267475-6f4h3cck 498 22 transcript transcript NN cord-267475-6f4h3cck 498 23 is be VBZ cord-267475-6f4h3cck 498 24 sometimes sometimes RB cord-267475-6f4h3cck 498 25 the the DT cord-267475-6f4h3cck 498 26 major major JJ cord-267475-6f4h3cck 498 27 functional functional JJ cord-267475-6f4h3cck 498 28 mRNA mrna NN cord-267475-6f4h3cck 499 1 ( ( -LRB- cord-267475-6f4h3cck 499 2 Andrea Andrea NNP cord-267475-6f4h3cck 499 3 and and CC cord-267475-6f4h3cck 499 4 Walsh Walsh NNP cord-267475-6f4h3cck 499 5 , , , cord-267475-6f4h3cck 499 6 1995 1995 CD cord-267475-6f4h3cck 499 7 ; ; : cord-267475-6f4h3cck 499 8 Babik Babik NNP cord-267475-6f4h3cck 499 9 et et NNP cord-267475-6f4h3cck 499 10 al al NNP cord-267475-6f4h3cck 499 11 . . NNP cord-267475-6f4h3cck 499 12 , , , cord-267475-6f4h3cck 499 13 1999 1999 CD cord-267475-6f4h3cck 499 14 ; ; : cord-267475-6f4h3cck 499 15 Ghilardi Ghilardi NNP cord-267475-6f4h3cck 499 16 et et NNP cord-267475-6f4h3cck 499 17 al al NNP cord-267475-6f4h3cck 499 18 . . NNP cord-267475-6f4h3cck 499 19 , , , cord-267475-6f4h3cck 499 20 1998 1998 CD cord-267475-6f4h3cck 499 21 ; ; : cord-267475-6f4h3cck 500 1 Mitsuhashi Mitsuhashi NNP cord-267475-6f4h3cck 500 2 and and CC cord-267475-6f4h3cck 500 3 Nikodem Nikodem NNP cord-267475-6f4h3cck 500 4 , , , cord-267475-6f4h3cck 500 5 1989 1989 CD cord-267475-6f4h3cck 500 6 ; ; : cord-267475-6f4h3cck 500 7 Nielsen Nielsen NNP cord-267475-6f4h3cck 500 8 et et NNP cord-267475-6f4h3cck 500 9 al al NNP cord-267475-6f4h3cck 500 10 . . NNP cord-267475-6f4h3cck 500 11 , , , cord-267475-6f4h3cck 500 12 1990 1990 CD cord-267475-6f4h3cck 500 13 ) ) -RRB- cord-267475-6f4h3cck 500 14 and and CC cord-267475-6f4h3cck 500 15 incompletely incompletely RB cord-267475-6f4h3cck 500 16 processed process VBN cord-267475-6f4h3cck 500 17 transcripts transcript NNS cord-267475-6f4h3cck 500 18 are be VBP cord-267475-6f4h3cck 500 19 sometimes sometimes RB cord-267475-6f4h3cck 500 20 more more RBR cord-267475-6f4h3cck 500 21 abundant abundant JJ cord-267475-6f4h3cck 500 22 than than IN cord-267475-6f4h3cck 500 23 the the DT cord-267475-6f4h3cck 500 24 fullyspliced fullyspliced JJ cord-267475-6f4h3cck 500 25 , , , cord-267475-6f4h3cck 500 26 translatable translatable JJ cord-267475-6f4h3cck 500 27 mRNA mRNA NNP cord-267475-6f4h3cck 500 28 ( ( -LRB- cord-267475-6f4h3cck 500 29 Boularand Boularand NNP cord-267475-6f4h3cck 500 30 et et NNP cord-267475-6f4h3cck 500 31 al al NNP cord-267475-6f4h3cck 500 32 . . . cord-267475-6f4h3cck 501 1 , , , cord-267475-6f4h3cck 501 2 1995 1995 CD cord-267475-6f4h3cck 501 3 ; ; : cord-267475-6f4h3cck 501 4 Frost Frost NNP cord-267475-6f4h3cck 501 5 et et FW cord-267475-6f4h3cck 501 6 al al NNP cord-267475-6f4h3cck 501 7 . . NNP cord-267475-6f4h3cck 501 8 , , , cord-267475-6f4h3cck 501 9 2000 2000 CD cord-267475-6f4h3cck 501 10 ; ; : cord-267475-6f4h3cck 501 11 Xie Xie NNP cord-267475-6f4h3cck 501 12 et et FW cord-267475-6f4h3cck 501 13 al al NNP cord-267475-6f4h3cck 501 14 . . NNP cord-267475-6f4h3cck 501 15 , , , cord-267475-6f4h3cck 501 16 1991 1991 CD cord-267475-6f4h3cck 501 17 ; ; : cord-267475-6f4h3cck 501 18 Zachar Zachar NNP cord-267475-6f4h3cck 501 19 et et NNP cord-267475-6f4h3cck 501 20 al al NNP cord-267475-6f4h3cck 501 21 . . NNP cord-267475-6f4h3cck 501 22 , , , cord-267475-6f4h3cck 501 23 1987 1987 CD cord-267475-6f4h3cck 501 24 ) ) -RRB- cord-267475-6f4h3cck 501 25 . . . cord-267475-6f4h3cck 502 1 Translational translational JJ cord-267475-6f4h3cck 502 2 regulation regulation NN cord-267475-6f4h3cck 502 3 mediated mediate VBN cord-267475-6f4h3cck 502 4 by by IN cord-267475-6f4h3cck 502 5 small small JJ cord-267475-6f4h3cck 502 6 upORFs uporfs NN cord-267475-6f4h3cck 502 7 is be VBZ cord-267475-6f4h3cck 502 8 important important JJ cord-267475-6f4h3cck 502 9 , , , cord-267475-6f4h3cck 502 10 as as IN cord-267475-6f4h3cck 502 11 discussed discuss VBN cord-267475-6f4h3cck 502 12 below below RB cord-267475-6f4h3cck 502 13 , , , cord-267475-6f4h3cck 502 14 but but CC cord-267475-6f4h3cck 502 15 equally equally RB cord-267475-6f4h3cck 502 16 important important JJ cord-267475-6f4h3cck 502 17 are be VBP cord-267475-6f4h3cck 502 18 non non JJ cord-267475-6f4h3cck 502 19 - - JJ cord-267475-6f4h3cck 502 20 translational translational JJ cord-267475-6f4h3cck 502 21 mechanisms mechanism NNS cord-267475-6f4h3cck 502 22 -use -use : cord-267475-6f4h3cck 502 23 of of IN cord-267475-6f4h3cck 502 24 alternative alternative JJ cord-267475-6f4h3cck 502 25 promoters promoter NNS cord-267475-6f4h3cck 502 26 or or CC cord-267475-6f4h3cck 502 27 splice splice VB cord-267475-6f4h3cck 502 28 sites site NNS cord-267475-6f4h3cck 503 1 -that -that : cord-267475-6f4h3cck 503 2 simplify simplify VBP cord-267475-6f4h3cck 503 3 the the DT cord-267475-6f4h3cck 503 4 5 5 CD cord-267475-6f4h3cck 503 5 0 0 CD cord-267475-6f4h3cck 503 6 UTR UTR NNP cord-267475-6f4h3cck 503 7 by by IN cord-267475-6f4h3cck 503 8 eliminating eliminate VBG cord-267475-6f4h3cck 503 9 upORFs uporfs NN cord-267475-6f4h3cck 503 10 in in IN cord-267475-6f4h3cck 503 11 certain certain JJ cord-267475-6f4h3cck 503 12 tissues tissue NNS cord-267475-6f4h3cck 503 13 or or CC cord-267475-6f4h3cck 503 14 at at IN cord-267475-6f4h3cck 503 15 certain certain JJ cord-267475-6f4h3cck 503 16 times time NNS cord-267475-6f4h3cck 503 17 when when WRB cord-267475-6f4h3cck 503 18 elevated elevated JJ cord-267475-6f4h3cck 503 19 synthesis synthesis NN cord-267475-6f4h3cck 503 20 of of IN cord-267475-6f4h3cck 503 21 the the DT cord-267475-6f4h3cck 503 22 protein protein NN cord-267475-6f4h3cck 503 23 is be VBZ cord-267475-6f4h3cck 503 24 required require VBN cord-267475-6f4h3cck 503 25 ( ( -LRB- cord-267475-6f4h3cck 503 26 Aizencang Aizencang NNP cord-267475-6f4h3cck 503 27 et et FW cord-267475-6f4h3cck 503 28 al al NNP cord-267475-6f4h3cck 503 29 . . . cord-267475-6f4h3cck 504 1 , , , cord-267475-6f4h3cck 504 2 2000 2000 CD cord-267475-6f4h3cck 504 3 ; ; : cord-267475-6f4h3cck 504 4 Anusaksathien Anusaksathien NNP cord-267475-6f4h3cck 504 5 et et NNP cord-267475-6f4h3cck 504 6 al al NNP cord-267475-6f4h3cck 504 7 . . NNP cord-267475-6f4h3cck 504 8 , , , cord-267475-6f4h3cck 504 9 2001 2001 CD cord-267475-6f4h3cck 504 10 ; ; : cord-267475-6f4h3cck 504 11 Arrick Arrick NNP cord-267475-6f4h3cck 504 12 et et NNP cord-267475-6f4h3cck 504 13 al al NNP cord-267475-6f4h3cck 504 14 . . . cord-267475-6f4h3cck 505 1 , , , cord-267475-6f4h3cck 505 2 1994 1994 CD cord-267475-6f4h3cck 505 3 ; ; : cord-267475-6f4h3cck 505 4 Babik Babik NNP cord-267475-6f4h3cck 505 5 et et NNP cord-267475-6f4h3cck 505 6 al al NNP cord-267475-6f4h3cck 505 7 . . NNP cord-267475-6f4h3cck 505 8 , , , cord-267475-6f4h3cck 505 9 1999 1999 CD cord-267475-6f4h3cck 505 10 ; ; : cord-267475-6f4h3cck 505 11 Brown Brown NNP cord-267475-6f4h3cck 505 12 et et NNP cord-267475-6f4h3cck 505 13 al al NNP cord-267475-6f4h3cck 505 14 . . NNP cord-267475-6f4h3cck 505 15 , , , cord-267475-6f4h3cck 505 16 1999 1999 CD cord-267475-6f4h3cck 506 1 ; ; : cord-267475-6f4h3cck 506 2 Horiuchi Horiuchi NNP cord-267475-6f4h3cck 506 3 et et NNP cord-267475-6f4h3cck 506 4 al al NNP cord-267475-6f4h3cck 506 5 . . . cord-267475-6f4h3cck 507 1 , , , cord-267475-6f4h3cck 507 2 1990 1990 CD cord-267475-6f4h3cck 507 3 ; ; : cord-267475-6f4h3cck 507 4 Landers Landers NNP cord-267475-6f4h3cck 507 5 et et NNP cord-267475-6f4h3cck 507 6 al al NNP cord-267475-6f4h3cck 507 7 . . NNP cord-267475-6f4h3cck 507 8 , , , cord-267475-6f4h3cck 507 9 1997 1997 CD cord-267475-6f4h3cck 507 10 ; ; : cord-267475-6f4h3cck 507 11 Lee Lee NNP cord-267475-6f4h3cck 507 12 et et NNP cord-267475-6f4h3cck 507 13 al al NNP cord-267475-6f4h3cck 507 14 . . NNP cord-267475-6f4h3cck 507 15 , , , cord-267475-6f4h3cck 507 16 2000 2000 CD cord-267475-6f4h3cck 508 1 ; ; : cord-267475-6f4h3cck 508 2 Nonaka Nonaka NNP cord-267475-6f4h3cck 508 3 et et NNP cord-267475-6f4h3cck 508 4 al al NNP cord-267475-6f4h3cck 508 5 . . . cord-267475-6f4h3cck 509 1 , , , cord-267475-6f4h3cck 509 2 1989 1989 CD cord-267475-6f4h3cck 509 3 ; ; : cord-267475-6f4h3cck 509 4 Phelps Phelps NNP cord-267475-6f4h3cck 509 5 et et NNP cord-267475-6f4h3cck 509 6 al al NNP cord-267475-6f4h3cck 509 7 . . NNP cord-267475-6f4h3cck 509 8 , , , cord-267475-6f4h3cck 509 9 1998 1998 CD cord-267475-6f4h3cck 509 10 ; ; : cord-267475-6f4h3cck 510 1 Ren Ren NNP cord-267475-6f4h3cck 510 2 and and CC cord-267475-6f4h3cck 510 3 Stiles Stiles NNP cord-267475-6f4h3cck 510 4 , , , cord-267475-6f4h3cck 510 5 1994 1994 CD cord-267475-6f4h3cck 510 6 ; ; : cord-267475-6f4h3cck 510 7 Steel Steel NNP cord-267475-6f4h3cck 510 8 et et NNP cord-267475-6f4h3cck 510 9 al al NNP cord-267475-6f4h3cck 510 10 . . NNP cord-267475-6f4h3cck 510 11 , , , cord-267475-6f4h3cck 510 12 1996 1996 CD cord-267475-6f4h3cck 511 1 ; ; : cord-267475-6f4h3cck 511 2 Teruya Teruya NNP cord-267475-6f4h3cck 511 3 et et NNP cord-267475-6f4h3cck 511 4 al al NNP cord-267475-6f4h3cck 511 5 . . NNP cord-267475-6f4h3cck 511 6 , , , cord-267475-6f4h3cck 511 7 1990 1990 CD cord-267475-6f4h3cck 511 8 ) ) -RRB- cord-267475-6f4h3cck 511 9 . . . cord-267475-6f4h3cck 512 1 Because because IN cord-267475-6f4h3cck 512 2 vertebrate vertebrate JJ cord-267475-6f4h3cck 512 3 mRNA mRNA NNP cord-267475-6f4h3cck 512 4 leader leader NN cord-267475-6f4h3cck 512 5 sequences sequence NNS cord-267475-6f4h3cck 512 6 are be VBP cord-267475-6f4h3cck 512 7 often often RB cord-267475-6f4h3cck 512 8 GC GC NNP cord-267475-6f4h3cck 512 9 - - HYPH cord-267475-6f4h3cck 512 10 rich rich JJ cord-267475-6f4h3cck 512 11 ( ( -LRB- cord-267475-6f4h3cck 512 12 Section section NN cord-267475-6f4h3cck 512 13 2.4 2.4 CD cord-267475-6f4h3cck 512 14 ) ) -RRB- cord-267475-6f4h3cck 512 15 , , , cord-267475-6f4h3cck 512 16 secondary secondary JJ cord-267475-6f4h3cck 512 17 structure structure NN cord-267475-6f4h3cck 512 18 near near IN cord-267475-6f4h3cck 512 19 the the DT cord-267475-6f4h3cck 512 20 5 5 CD cord-267475-6f4h3cck 512 21 0 0 CD cord-267475-6f4h3cck 512 22 end end NN cord-267475-6f4h3cck 512 23 might may MD cord-267475-6f4h3cck 512 24 impair impair VB cord-267475-6f4h3cck 512 25 translation translation NN cord-267475-6f4h3cck 512 26 even even RB cord-267475-6f4h3cck 512 27 more more RBR cord-267475-6f4h3cck 512 28 than than IN cord-267475-6f4h3cck 512 29 the the DT cord-267475-6f4h3cck 512 30 presence presence NN cord-267475-6f4h3cck 512 31 of of IN cord-267475-6f4h3cck 512 32 upstream upstream JJ cord-267475-6f4h3cck 512 33 AUG AUG NNP cord-267475-6f4h3cck 512 34 codons codon NNS cord-267475-6f4h3cck 512 35 . . . cord-267475-6f4h3cck 513 1 Thus thus RB cord-267475-6f4h3cck 513 2 , , , cord-267475-6f4h3cck 513 3 it -PRON- PRP cord-267475-6f4h3cck 513 4 is be VBZ cord-267475-6f4h3cck 513 5 not not RB cord-267475-6f4h3cck 513 6 surprising surprising JJ cord-267475-6f4h3cck 513 7 that that IN cord-267475-6f4h3cck 513 8 eliminating eliminate VBG cord-267475-6f4h3cck 513 9 upstream upstream JJ cord-267475-6f4h3cck 513 10 AUG AUG NNP cord-267475-6f4h3cck 513 11 codons codon NNS cord-267475-6f4h3cck 513 12 does do VBZ cord-267475-6f4h3cck 513 13 not not RB cord-267475-6f4h3cck 513 14 improve improve VB cord-267475-6f4h3cck 513 15 translation translation NN cord-267475-6f4h3cck 513 16 in in IN cord-267475-6f4h3cck 513 17 every every DT cord-267475-6f4h3cck 513 18 case case NN cord-267475-6f4h3cck 513 19 ( ( -LRB- cord-267475-6f4h3cck 513 20 Rao Rao NNP cord-267475-6f4h3cck 513 21 et et NNP cord-267475-6f4h3cck 513 22 al al NNP cord-267475-6f4h3cck 513 23 . . . cord-267475-6f4h3cck 514 1 , , , cord-267475-6f4h3cck 514 2 1988 1988 CD cord-267475-6f4h3cck 514 3 ; ; : cord-267475-6f4h3cck 514 4 Wood Wood NNP cord-267475-6f4h3cck 514 5 et et NNP cord-267475-6f4h3cck 514 6 al al NNP cord-267475-6f4h3cck 514 7 . . NNP cord-267475-6f4h3cck 514 8 , , , cord-267475-6f4h3cck 514 9 1996 1996 CD cord-267475-6f4h3cck 514 10 ) ) -RRB- cord-267475-6f4h3cck 514 11 . . . cord-267475-6f4h3cck 515 1 In in IN cord-267475-6f4h3cck 515 2 many many JJ cord-267475-6f4h3cck 515 3 cases case NNS cord-267475-6f4h3cck 515 4 , , , cord-267475-6f4h3cck 515 5 however however RB cord-267475-6f4h3cck 515 6 , , , cord-267475-6f4h3cck 515 7 mutations mutation NNS cord-267475-6f4h3cck 515 8 targeted target VBN cord-267475-6f4h3cck 515 9 to to IN cord-267475-6f4h3cck 515 10 the the DT cord-267475-6f4h3cck 515 11 upstream upstream JJ cord-267475-6f4h3cck 515 12 AUG AUG NNP cord-267475-6f4h3cck 515 13 codons codon NNS cord-267475-6f4h3cck 515 14 confirmed confirm VBD cord-267475-6f4h3cck 515 15 their -PRON- PRP$ cord-267475-6f4h3cck 515 16 role role NN cord-267475-6f4h3cck 515 17 in in IN cord-267475-6f4h3cck 515 18 restricting restrict VBG cord-267475-6f4h3cck 515 19 translation translation NN cord-267475-6f4h3cck 515 20 from from IN cord-267475-6f4h3cck 515 21 downstream downstream NN cord-267475-6f4h3cck 516 1 ( ( -LRB- cord-267475-6f4h3cck 516 2 Anant Anant NNP cord-267475-6f4h3cck 516 3 et et NNP cord-267475-6f4h3cck 516 4 al al NNP cord-267475-6f4h3cck 516 5 . . . cord-267475-6f4h3cck 517 1 , , , cord-267475-6f4h3cck 517 2 2002 2002 CD cord-267475-6f4h3cck 517 3 ; ; : cord-267475-6f4h3cck 517 4 Babik Babik NNP cord-267475-6f4h3cck 517 5 et et NNP cord-267475-6f4h3cck 517 6 al al NNP cord-267475-6f4h3cck 517 7 . . NNP cord-267475-6f4h3cck 517 8 , , , cord-267475-6f4h3cck 517 9 1999 1999 CD cord-267475-6f4h3cck 517 10 ; ; : cord-267475-6f4h3cck 518 1 Bates Bates NNP cord-267475-6f4h3cck 518 2 et et NNP cord-267475-6f4h3cck 518 3 al al NNP cord-267475-6f4h3cck 518 4 . . NNP cord-267475-6f4h3cck 518 5 , , , cord-267475-6f4h3cck 518 6 1991 1991 CD cord-267475-6f4h3cck 518 7 ; ; : cord-267475-6f4h3cck 518 8 Brown Brown NNP cord-267475-6f4h3cck 518 9 et et NNP cord-267475-6f4h3cck 518 10 al al NNP cord-267475-6f4h3cck 518 11 . . NNP cord-267475-6f4h3cck 518 12 , , , cord-267475-6f4h3cck 518 13 1999 1999 CD cord-267475-6f4h3cck 519 1 ; ; : cord-267475-6f4h3cck 519 2 Child Child NNP cord-267475-6f4h3cck 519 3 et et NNP cord-267475-6f4h3cck 519 4 al al NNP cord-267475-6f4h3cck 519 5 . . . cord-267475-6f4h3cck 520 1 , , , cord-267475-6f4h3cck 520 2 1999a 1999a CD cord-267475-6f4h3cck 520 3 ; ; : cord-267475-6f4h3cck 520 4 Gereben Gereben NNP cord-267475-6f4h3cck 520 5 et et NNP cord-267475-6f4h3cck 520 6 al al NNP cord-267475-6f4h3cck 520 7 . . NNP cord-267475-6f4h3cck 520 8 , , , cord-267475-6f4h3cck 520 9 2002 2002 CD cord-267475-6f4h3cck 520 10 ; ; : cord-267475-6f4h3cck 521 1 Ghilardi Ghilardi NNP cord-267475-6f4h3cck 521 2 et et NNP cord-267475-6f4h3cck 521 3 al al NNP cord-267475-6f4h3cck 521 4 . . NNP cord-267475-6f4h3cck 521 5 , , , cord-267475-6f4h3cck 521 6 1998 1998 CD cord-267475-6f4h3cck 521 7 ; ; : cord-267475-6f4h3cck 521 8 Griffin Griffin NNP cord-267475-6f4h3cck 521 9 et et NNP cord-267475-6f4h3cck 521 10 al al NNP cord-267475-6f4h3cck 521 11 . . NNP cord-267475-6f4h3cck 521 12 , , , cord-267475-6f4h3cck 521 13 2001 2001 CD cord-267475-6f4h3cck 522 1 ; ; : cord-267475-6f4h3cck 522 2 Harigai Harigai NNP cord-267475-6f4h3cck 522 3 et et NNP cord-267475-6f4h3cck 522 4 al al NNP cord-267475-6f4h3cck 522 5 . . . cord-267475-6f4h3cck 523 1 , , , cord-267475-6f4h3cck 523 2 1996 1996 CD cord-267475-6f4h3cck 523 3 ; ; : cord-267475-6f4h3cck 523 4 Kos Kos NNP cord-267475-6f4h3cck 523 5 et et NNP cord-267475-6f4h3cck 523 6 al al NNP cord-267475-6f4h3cck 523 7 . . . cord-267475-6f4h3cck 524 1 , , , cord-267475-6f4h3cck 524 2 2002 2002 CD cord-267475-6f4h3cck 524 3 ; ; : cord-267475-6f4h3cck 524 4 Lee Lee NNP cord-267475-6f4h3cck 524 5 et et NNP cord-267475-6f4h3cck 524 6 al al NNP cord-267475-6f4h3cck 524 7 . . NNP cord-267475-6f4h3cck 524 8 , , , cord-267475-6f4h3cck 524 9 1999 1999 CD cord-267475-6f4h3cck 524 10 ; ; : cord-267475-6f4h3cck 524 11 Marth Marth NNP cord-267475-6f4h3cck 524 12 et et NNP cord-267475-6f4h3cck 524 13 al al NNP cord-267475-6f4h3cck 524 14 . . NNP cord-267475-6f4h3cck 524 15 , , , cord-267475-6f4h3cck 524 16 1988 1988 CD cord-267475-6f4h3cck 525 1 ; ; : cord-267475-6f4h3cck 525 2 Meijer Meijer NNP cord-267475-6f4h3cck 525 3 et et NNP cord-267475-6f4h3cck 525 4 al al NNP cord-267475-6f4h3cck 525 5 . . NNP cord-267475-6f4h3cck 525 6 , , , cord-267475-6f4h3cck 525 7 2000 2000 CD cord-267475-6f4h3cck 525 8 ; ; : cord-267475-6f4h3cck 525 9 Pecqueur Pecqueur NNP cord-267475-6f4h3cck 525 10 et et NNP cord-267475-6f4h3cck 525 11 al al NNP cord-267475-6f4h3cck 525 12 . . NNP cord-267475-6f4h3cck 525 13 , , , cord-267475-6f4h3cck 525 14 2001 2001 CD cord-267475-6f4h3cck 525 15 ; ; : cord-267475-6f4h3cck 525 16 Ren Ren NNP cord-267475-6f4h3cck 525 17 and and CC cord-267475-6f4h3cck 525 18 Stiles Stiles NNP cord-267475-6f4h3cck 525 19 , , , cord-267475-6f4h3cck 525 20 1994 1994 CD cord-267475-6f4h3cck 525 21 ; ; : cord-267475-6f4h3cck 525 22 Steel Steel NNP cord-267475-6f4h3cck 525 23 et et NNP cord-267475-6f4h3cck 525 24 al al NNP cord-267475-6f4h3cck 525 25 . . NNP cord-267475-6f4h3cck 525 26 , , , cord-267475-6f4h3cck 525 27 1996 1996 CD cord-267475-6f4h3cck 525 28 ; ; : cord-267475-6f4h3cck 525 29 Tanaka Tanaka NNP cord-267475-6f4h3cck 525 30 et et NNP cord-267475-6f4h3cck 525 31 al al NNP cord-267475-6f4h3cck 525 32 . . NNP cord-267475-6f4h3cck 525 33 , , , cord-267475-6f4h3cck 525 34 2001 2001 CD cord-267475-6f4h3cck 525 35 ; ; : cord-267475-6f4h3cck 525 36 Tsai Tsai NNP cord-267475-6f4h3cck 525 37 et et NNP cord-267475-6f4h3cck 525 38 al al NNP cord-267475-6f4h3cck 525 39 . . NNP cord-267475-6f4h3cck 525 40 , , , cord-267475-6f4h3cck 525 41 2002 2002 CD cord-267475-6f4h3cck 525 42 ; ; : cord-267475-6f4h3cck 525 43 Wang Wang NNP cord-267475-6f4h3cck 525 44 and and CC cord-267475-6f4h3cck 525 45 Wessler Wessler NNP cord-267475-6f4h3cck 525 46 , , , cord-267475-6f4h3cck 525 47 1998 1998 CD cord-267475-6f4h3cck 525 48 ; ; : cord-267475-6f4h3cck 525 49 Wang Wang NNP cord-267475-6f4h3cck 525 50 and and CC cord-267475-6f4h3cck 525 51 Rothnagel Rothnagel NNP cord-267475-6f4h3cck 525 52 , , , cord-267475-6f4h3cck 525 53 2001 2001 CD cord-267475-6f4h3cck 525 54 ; ; : cord-267475-6f4h3cck 525 55 Wera Wera NNP cord-267475-6f4h3cck 525 56 et et NNP cord-267475-6f4h3cck 525 57 al al NNP cord-267475-6f4h3cck 525 58 . . NNP cord-267475-6f4h3cck 525 59 , , , cord-267475-6f4h3cck 525 60 1995 1995 CD cord-267475-6f4h3cck 525 61 ; ; : cord-267475-6f4h3cck 525 62 Wu Wu NNP cord-267475-6f4h3cck 525 63 et et NNP cord-267475-6f4h3cck 525 64 al al NNP cord-267475-6f4h3cck 525 65 . . NNP cord-267475-6f4h3cck 525 66 , , , cord-267475-6f4h3cck 525 67 2002 2002 CD cord-267475-6f4h3cck 525 68 ) ) -RRB- cord-267475-6f4h3cck 525 69 . . . cord-267475-6f4h3cck 526 1 This this DT cord-267475-6f4h3cck 526 2 occurs occur VBZ cord-267475-6f4h3cck 526 3 by by IN cord-267475-6f4h3cck 526 4 a a DT cord-267475-6f4h3cck 526 5 variety variety NN cord-267475-6f4h3cck 526 6 of of IN cord-267475-6f4h3cck 526 7 mechanisms mechanism NNS cord-267475-6f4h3cck 526 8 , , , cord-267475-6f4h3cck 526 9 as as IN cord-267475-6f4h3cck 526 10 summarized summarize VBN cord-267475-6f4h3cck 526 11 in in IN cord-267475-6f4h3cck 526 12 Fig Fig NNP cord-267475-6f4h3cck 526 13 . . . cord-267475-6f4h3cck 527 1 3 3 CD cord-267475-6f4h3cck 527 2 and and CC cord-267475-6f4h3cck 527 3 discussed discuss VBD cord-267475-6f4h3cck 527 4 next next RB cord-267475-6f4h3cck 527 5 . . . cord-267475-6f4h3cck 528 1 While while IN cord-267475-6f4h3cck 528 2 the the DT cord-267475-6f4h3cck 528 3 efficiency efficiency NN cord-267475-6f4h3cck 528 4 of of IN cord-267475-6f4h3cck 528 5 reinitiation reinitiation NN cord-267475-6f4h3cck 528 6 varies vary VBZ cord-267475-6f4h3cck 528 7 , , , cord-267475-6f4h3cck 528 8 there there EX cord-267475-6f4h3cck 528 9 is be VBZ cord-267475-6f4h3cck 528 10 almost almost RB cord-267475-6f4h3cck 528 11 always always RB cord-267475-6f4h3cck 528 12 a a DT cord-267475-6f4h3cck 528 13 penalty penalty NN cord-267475-6f4h3cck 528 14 -demonstrable -demonstrable JJ cord-267475-6f4h3cck 528 15 by by IN cord-267475-6f4h3cck 528 16 showing show VBG cord-267475-6f4h3cck 528 17 an an DT cord-267475-6f4h3cck 528 18 increase increase NN cord-267475-6f4h3cck 528 19 in in IN cord-267475-6f4h3cck 528 20 translation translation NN cord-267475-6f4h3cck 528 21 when when WRB cord-267475-6f4h3cck 528 22 the the DT cord-267475-6f4h3cck 528 23 upORF uporf NN cord-267475-6f4h3cck 528 24 is be VBZ cord-267475-6f4h3cck 528 25 deleted delete VBN cord-267475-6f4h3cck 528 26 -and -and : cord-267475-6f4h3cck 528 27 the the DT cord-267475-6f4h3cck 528 28 penalty penalty NN cord-267475-6f4h3cck 528 29 can can MD cord-267475-6f4h3cck 528 30 be be VB cord-267475-6f4h3cck 528 31 severe severe JJ cord-267475-6f4h3cck 528 32 . . . cord-267475-6f4h3cck 529 1 Thus thus RB cord-267475-6f4h3cck 529 2 , , , cord-267475-6f4h3cck 529 3 the the DT cord-267475-6f4h3cck 529 4 simplest simple JJS cord-267475-6f4h3cck 529 5 function function NN cord-267475-6f4h3cck 529 6 of of IN cord-267475-6f4h3cck 529 7 small small JJ cord-267475-6f4h3cck 529 8 upORFs uporfs NN cord-267475-6f4h3cck 529 9 is be VBZ cord-267475-6f4h3cck 529 10 to to TO cord-267475-6f4h3cck 529 11 limit limit VB cord-267475-6f4h3cck 529 12 production production NN cord-267475-6f4h3cck 529 13 of of IN cord-267475-6f4h3cck 529 14 the the DT cord-267475-6f4h3cck 529 15 protein protein NN cord-267475-6f4h3cck 529 16 encoded encode VBN cord-267475-6f4h3cck 529 17 in in IN cord-267475-6f4h3cck 529 18 the the DT cord-267475-6f4h3cck 529 19 full full JJ cord-267475-6f4h3cck 529 20 - - HYPH cord-267475-6f4h3cck 529 21 length length NN cord-267475-6f4h3cck 529 22 ORF ORF NNP cord-267475-6f4h3cck 529 23 by by IN cord-267475-6f4h3cck 529 24 making make VBG cord-267475-6f4h3cck 529 25 downstream downstream JJ cord-267475-6f4h3cck 529 26 translation translation NN cord-267475-6f4h3cck 529 27 dependent dependent JJ cord-267475-6f4h3cck 529 28 on on IN cord-267475-6f4h3cck 529 29 an an DT cord-267475-6f4h3cck 529 30 inefficient inefficient JJ cord-267475-6f4h3cck 529 31 reinitiation reinitiation NN cord-267475-6f4h3cck 529 32 mechanism mechanism NN cord-267475-6f4h3cck 529 33 ( ( -LRB- cord-267475-6f4h3cck 529 34 Fig Fig NNP cord-267475-6f4h3cck 529 35 . . . cord-267475-6f4h3cck 529 36 3A 3A NNP cord-267475-6f4h3cck 529 37 ) ) -RRB- cord-267475-6f4h3cck 529 38 . . . cord-267475-6f4h3cck 530 1 The the DT cord-267475-6f4h3cck 530 2 best well RBS cord-267475-6f4h3cck 530 3 studied study VBN cord-267475-6f4h3cck 530 4 example example NN cord-267475-6f4h3cck 530 5 is be VBZ cord-267475-6f4h3cck 530 6 yeast yeast NN cord-267475-6f4h3cck 530 7 GCN4 GCN4 NNP cord-267475-6f4h3cck 530 8 , , , cord-267475-6f4h3cck 530 9 which which WDT cord-267475-6f4h3cck 530 10 initiates initiate VBZ cord-267475-6f4h3cck 530 11 from from IN cord-267475-6f4h3cck 530 12 the the DT cord-267475-6f4h3cck 530 13 fifth fifth JJ cord-267475-6f4h3cck 530 14 AUG AUG NNP cord-267475-6f4h3cck 530 15 codon codon NN cord-267475-6f4h3cck 530 16 in in IN cord-267475-6f4h3cck 530 17 the the DT cord-267475-6f4h3cck 530 18 mRNA mrna NN cord-267475-6f4h3cck 530 19 ; ; : cord-267475-6f4h3cck 530 20 the the DT cord-267475-6f4h3cck 530 21 long long JJ cord-267475-6f4h3cck 530 22 leader leader NN cord-267475-6f4h3cck 530 23 sequence sequence NN cord-267475-6f4h3cck 530 24 contains contain VBZ cord-267475-6f4h3cck 530 25 four four CD cord-267475-6f4h3cck 530 26 small small JJ cord-267475-6f4h3cck 530 27 upORFs uporfs NN cord-267475-6f4h3cck 530 28 . . . cord-267475-6f4h3cck 531 1 In in IN cord-267475-6f4h3cck 531 2 a a DT cord-267475-6f4h3cck 531 3 series series NN cord-267475-6f4h3cck 531 4 of of IN cord-267475-6f4h3cck 531 5 classic classic JJ cord-267475-6f4h3cck 531 6 experiments experiment NNS cord-267475-6f4h3cck 531 7 , , , cord-267475-6f4h3cck 531 8 Hinnebusch Hinnebusch NNP cord-267475-6f4h3cck 531 9 ( ( -LRB- cord-267475-6f4h3cck 531 10 1997 1997 CD cord-267475-6f4h3cck 531 11 ) ) -RRB- cord-267475-6f4h3cck 531 12 was be VBD cord-267475-6f4h3cck 531 13 able able JJ cord-267475-6f4h3cck 531 14 to to TO cord-267475-6f4h3cck 531 15 reconstruct reconstruct VB cord-267475-6f4h3cck 531 16 GCN4 GCN4 NNP cord-267475-6f4h3cck 531 17 regulation regulation NN cord-267475-6f4h3cck 531 18 using use VBG cord-267475-6f4h3cck 531 19 only only RB cord-267475-6f4h3cck 531 20 the the DT cord-267475-6f4h3cck 531 21 first first JJ cord-267475-6f4h3cck 531 22 and and CC cord-267475-6f4h3cck 531 23 fourth fourth JJ cord-267475-6f4h3cck 531 24 upORFs uporfs NN cord-267475-6f4h3cck 531 25 , , , cord-267475-6f4h3cck 531 26 and and CC cord-267475-6f4h3cck 531 27 I -PRON- PRP cord-267475-6f4h3cck 531 28 will will MD cord-267475-6f4h3cck 531 29 explain explain VB cord-267475-6f4h3cck 531 30 what what WP cord-267475-6f4h3cck 531 31 happens happen VBZ cord-267475-6f4h3cck 531 32 in in IN cord-267475-6f4h3cck 531 33 that that DT cord-267475-6f4h3cck 531 34 simplified simplified JJ cord-267475-6f4h3cck 531 35 case case NN cord-267475-6f4h3cck 531 36 . . . cord-267475-6f4h3cck 532 1 UpORF1 UpORF1 NNP cord-267475-6f4h3cck 532 2 is be VBZ cord-267475-6f4h3cck 532 3 always always RB cord-267475-6f4h3cck 532 4 translated translate VBN cord-267475-6f4h3cck 532 5 efficiently efficiently RB cord-267475-6f4h3cck 532 6 ( ( -LRB- cord-267475-6f4h3cck 532 7 it -PRON- PRP cord-267475-6f4h3cck 532 8 is be VBZ cord-267475-6f4h3cck 532 9 the the DT cord-267475-6f4h3cck 532 10 first first JJ cord-267475-6f4h3cck 532 11 AUG AUG NNP cord-267475-6f4h3cck 532 12 in in IN cord-267475-6f4h3cck 532 13 the the DT cord-267475-6f4h3cck 532 14 mRNA mrna NN cord-267475-6f4h3cck 532 15 ) ) -RRB- cord-267475-6f4h3cck 532 16 , , , cord-267475-6f4h3cck 532 17 after after IN cord-267475-6f4h3cck 532 18 which which WDT cord-267475-6f4h3cck 532 19 ribosomes ribosome VBZ cord-267475-6f4h3cck 532 20 resume resume NN cord-267475-6f4h3cck 532 21 scanning scanning NN cord-267475-6f4h3cck 532 22 and and CC cord-267475-6f4h3cck 532 23 reinitiate reinitiate VB cord-267475-6f4h3cck 532 24 , , , cord-267475-6f4h3cck 532 25 usually usually RB cord-267475-6f4h3cck 532 26 , , , cord-267475-6f4h3cck 532 27 at at IN cord-267475-6f4h3cck 532 28 upORF4 upORF4 NNP cord-267475-6f4h3cck 532 29 . . . cord-267475-6f4h3cck 533 1 UpORF4 UpORF4 NNP cord-267475-6f4h3cck 533 2 is be VBZ cord-267475-6f4h3cck 533 3 unusual unusual JJ cord-267475-6f4h3cck 533 4 in in IN cord-267475-6f4h3cck 533 5 that that IN cord-267475-6f4h3cck 533 6 its -PRON- PRP$ cord-267475-6f4h3cck 533 7 translation translation NN cord-267475-6f4h3cck 533 8 precludes preclude VBZ cord-267475-6f4h3cck 533 9 further further JJ cord-267475-6f4h3cck 533 10 reinitiation reinitiation NN cord-267475-6f4h3cck 533 11 events event NNS cord-267475-6f4h3cck 533 12 : : : cord-267475-6f4h3cck 533 13 thus thus RB cord-267475-6f4h3cck 533 14 , , , cord-267475-6f4h3cck 533 15 when when WRB cord-267475-6f4h3cck 533 16 upORF4 upORF4 NNP cord-267475-6f4h3cck 533 17 is be VBZ cord-267475-6f4h3cck 533 18 translated translate VBN cord-267475-6f4h3cck 533 19 , , , cord-267475-6f4h3cck 533 20 GCN4 GCN4 NNP cord-267475-6f4h3cck 533 21 is be VBZ cord-267475-6f4h3cck 533 22 not not RB cord-267475-6f4h3cck 533 23 . . . cord-267475-6f4h3cck 534 1 That that DT cord-267475-6f4h3cck 534 2 is be VBZ cord-267475-6f4h3cck 534 3 the the DT cord-267475-6f4h3cck 534 4 situation situation NN cord-267475-6f4h3cck 534 5 in in IN cord-267475-6f4h3cck 534 6 yeast yeast NN cord-267475-6f4h3cck 534 7 cultures culture NNS cord-267475-6f4h3cck 534 8 that that WDT cord-267475-6f4h3cck 534 9 have have VBP cord-267475-6f4h3cck 534 10 adequate adequate JJ cord-267475-6f4h3cck 534 11 nutrients nutrient NNS cord-267475-6f4h3cck 534 12 . . . cord-267475-6f4h3cck 535 1 Starvation starvation NN cord-267475-6f4h3cck 535 2 for for IN cord-267475-6f4h3cck 535 3 amino amino JJ cord-267475-6f4h3cck 535 4 acids acid NNS cord-267475-6f4h3cck 535 5 , , , cord-267475-6f4h3cck 535 6 however however RB cord-267475-6f4h3cck 535 7 , , , cord-267475-6f4h3cck 535 8 causes cause VBZ cord-267475-6f4h3cck 535 9 some some DT cord-267475-6f4h3cck 535 10 ribosomes ribosome NNS cord-267475-6f4h3cck 535 11 to to TO cord-267475-6f4h3cck 535 12 bypass bypass VB cord-267475-6f4h3cck 535 13 the the DT cord-267475-6f4h3cck 535 14 inhibitory inhibitory JJ cord-267475-6f4h3cck 535 15 upORF4 upORF4 NNP cord-267475-6f4h3cck 535 16 and and CC cord-267475-6f4h3cck 535 17 reinitiate reinitiate VB cord-267475-6f4h3cck 535 18 instead instead RB cord-267475-6f4h3cck 535 19 farther farther RB cord-267475-6f4h3cck 535 20 downstream downstream RB cord-267475-6f4h3cck 535 21 . . . cord-267475-6f4h3cck 536 1 This this DT cord-267475-6f4h3cck 536 2 happens happen VBZ cord-267475-6f4h3cck 536 3 because because IN cord-267475-6f4h3cck 536 4 starvation starvation NN cord-267475-6f4h3cck 536 5 creates create VBZ cord-267475-6f4h3cck 536 6 a a DT cord-267475-6f4h3cck 536 7 pool pool NN cord-267475-6f4h3cck 536 8 of of IN cord-267475-6f4h3cck 536 9 uncharged uncharged JJ cord-267475-6f4h3cck 536 10 tRNAs trna NNS cord-267475-6f4h3cck 536 11 which which WDT cord-267475-6f4h3cck 536 12 activate activate VBP cord-267475-6f4h3cck 536 13 a a DT cord-267475-6f4h3cck 536 14 protein protein NN cord-267475-6f4h3cck 536 15 kinase kinase NN cord-267475-6f4h3cck 536 16 that that WDT cord-267475-6f4h3cck 536 17 phosphorylates phosphorylate VBZ cord-267475-6f4h3cck 536 18 , , , cord-267475-6f4h3cck 536 19 and and CC cord-267475-6f4h3cck 536 20 thus thus RB cord-267475-6f4h3cck 536 21 partially partially RB cord-267475-6f4h3cck 536 22 inactivates inactivate VBZ cord-267475-6f4h3cck 536 23 , , , cord-267475-6f4h3cck 537 1 eIF2 eIF2 NNP cord-267475-6f4h3cck 537 2 . . . cord-267475-6f4h3cck 538 1 When when WRB cord-267475-6f4h3cck 538 2 eIF2 eIF2 NNP cord-267475-6f4h3cck 538 3 levels level NNS cord-267475-6f4h3cck 538 4 fall fall VBP cord-267475-6f4h3cck 538 5 , , , cord-267475-6f4h3cck 538 6 it -PRON- PRP cord-267475-6f4h3cck 538 7 takes take VBZ cord-267475-6f4h3cck 538 8 longer long RBR cord-267475-6f4h3cck 538 9 for for IN cord-267475-6f4h3cck 538 10 ribosomes ribosome NNS cord-267475-6f4h3cck 538 11 to to TO cord-267475-6f4h3cck 538 12 reacquire reacquire VB cord-267475-6f4h3cck 538 13 Met Met NNP cord-267475-6f4h3cck 538 14 - - HYPH cord-267475-6f4h3cck 538 15 tRNA tRNA NNP cord-267475-6f4h3cck 538 16 i i PRP cord-267475-6f4h3cck 538 17 and and CC cord-267475-6f4h3cck 538 18 thus thus RB cord-267475-6f4h3cck 538 19 become become VB cord-267475-6f4h3cck 538 20 competent competent JJ cord-267475-6f4h3cck 538 21 to to TO cord-267475-6f4h3cck 538 22 reinitiate reinitiate VB cord-267475-6f4h3cck 538 23 . . . cord-267475-6f4h3cck 539 1 The the DT cord-267475-6f4h3cck 539 2 slower slow JJR cord-267475-6f4h3cck 539 3 acquisition acquisition NN cord-267475-6f4h3cck 539 4 of of IN cord-267475-6f4h3cck 539 5 competence competence NN cord-267475-6f4h3cck 539 6 means mean VBZ cord-267475-6f4h3cck 539 7 that that IN cord-267475-6f4h3cck 539 8 some some DT cord-267475-6f4h3cck 539 9 ribosomes ribosome NNS cord-267475-6f4h3cck 539 10 , , , cord-267475-6f4h3cck 539 11 scanning scan VBG cord-267475-6f4h3cck 539 12 in in IN cord-267475-6f4h3cck 539 13 the the DT cord-267475-6f4h3cck 539 14 reinitiation reinitiation NN cord-267475-6f4h3cck 539 15 mode mode NN cord-267475-6f4h3cck 539 16 , , , cord-267475-6f4h3cck 539 17 will will MD cord-267475-6f4h3cck 539 18 bypass bypass VB cord-267475-6f4h3cck 539 19 the the DT cord-267475-6f4h3cck 539 20 nearby nearby JJ cord-267475-6f4h3cck 539 21 upORF4 upORF4 NNP cord-267475-6f4h3cck 539 22 and and CC cord-267475-6f4h3cck 539 23 can can MD cord-267475-6f4h3cck 539 24 thus thus RB cord-267475-6f4h3cck 539 25 reach reach VB cord-267475-6f4h3cck 539 26 the the DT cord-267475-6f4h3cck 539 27 downstream downstream JJ cord-267475-6f4h3cck 539 28 GCN4 GCN4 NNP cord-267475-6f4h3cck 539 29 start start NN cord-267475-6f4h3cck 539 30 site site NN cord-267475-6f4h3cck 539 31 . . . cord-267475-6f4h3cck 540 1 Three three CD cord-267475-6f4h3cck 540 2 general general JJ cord-267475-6f4h3cck 540 3 lessons lesson NNS cord-267475-6f4h3cck 540 4 from from IN cord-267475-6f4h3cck 540 5 the the DT cord-267475-6f4h3cck 540 6 GCN4 GCN4 NNP cord-267475-6f4h3cck 540 7 story story NN cord-267475-6f4h3cck 540 8 appear appear VBP cord-267475-6f4h3cck 540 9 to to TO cord-267475-6f4h3cck 540 10 carry carry VB cord-267475-6f4h3cck 540 11 over over RP cord-267475-6f4h3cck 540 12 to to IN cord-267475-6f4h3cck 540 13 mammals mammal NNS cord-267475-6f4h3cck 540 14 . . . cord-267475-6f4h3cck 541 1 ( ( -LRB- cord-267475-6f4h3cck 541 2 i i NN cord-267475-6f4h3cck 541 3 ) ) -RRB- cord-267475-6f4h3cck 542 1 Fig Fig NNP cord-267475-6f4h3cck 542 2 . . . cord-267475-6f4h3cck 543 1 3A 3A NNP cord-267475-6f4h3cck 543 2 lists list VBZ cord-267475-6f4h3cck 543 3 some some DT cord-267475-6f4h3cck 543 4 examples example NNS cord-267475-6f4h3cck 543 5 of of IN cord-267475-6f4h3cck 543 6 mammalian mammalian NN cord-267475-6f4h3cck 543 7 mRNAs mRNAs NNPS cord-267475-6f4h3cck 543 8 that that WDT cord-267475-6f4h3cck 543 9 are be VBP cord-267475-6f4h3cck 543 10 translated translate VBN cord-267475-6f4h3cck 543 11 inefficiently inefficiently RB cord-267475-6f4h3cck 543 12 due due JJ cord-267475-6f4h3cck 543 13 to to IN cord-267475-6f4h3cck 543 14 small small JJ cord-267475-6f4h3cck 543 15 upORFs uporfs NN cord-267475-6f4h3cck 543 16 ; ; : cord-267475-6f4h3cck 543 17 many many JJ cord-267475-6f4h3cck 543 18 other other JJ cord-267475-6f4h3cck 543 19 examples example NNS cord-267475-6f4h3cck 543 20 were be VBD cord-267475-6f4h3cck 543 21 cited cite VBN cord-267475-6f4h3cck 543 22 in in IN cord-267475-6f4h3cck 543 23 Section section NN cord-267475-6f4h3cck 543 24 4.2 4.2 CD cord-267475-6f4h3cck 543 25 . . . cord-267475-6f4h3cck 544 1 ( ( -LRB- cord-267475-6f4h3cck 544 2 ii ii LS cord-267475-6f4h3cck 544 3 ) ) -RRB- cord-267475-6f4h3cck 544 4 Experimental experimental JJ cord-267475-6f4h3cck 544 5 manipulations manipulation NNS cord-267475-6f4h3cck 544 6 with with IN cord-267475-6f4h3cck 544 7 C C NNP cord-267475-6f4h3cck 544 8 / / SYM cord-267475-6f4h3cck 544 9 EBPb EBPb NNP cord-267475-6f4h3cck 544 10 mRNA mrna NN cord-267475-6f4h3cck 545 1 ( ( -LRB- cord-267475-6f4h3cck 545 2 Fig Fig NNP cord-267475-6f4h3cck 545 3 . . . cord-267475-6f4h3cck 545 4 1B 1b LS cord-267475-6f4h3cck 545 5 ) ) -RRB- cord-267475-6f4h3cck 545 6 support support VBP cord-267475-6f4h3cck 545 7 the the DT cord-267475-6f4h3cck 545 8 interpretation interpretation NN cord-267475-6f4h3cck 545 9 that that IN cord-267475-6f4h3cck 545 10 an an DT cord-267475-6f4h3cck 545 11 AUG AUG NNP cord-267475-6f4h3cck 545 12 codon codon NN cord-267475-6f4h3cck 545 13 which which WDT cord-267475-6f4h3cck 545 14 follows follow VBZ cord-267475-6f4h3cck 545 15 the the DT cord-267475-6f4h3cck 545 16 upORF uporf JJ cord-267475-6f4h3cck 545 17 too too RB cord-267475-6f4h3cck 545 18 closely closely RB cord-267475-6f4h3cck 545 19 is be VBZ cord-267475-6f4h3cck 545 20 skipped skip VBN cord-267475-6f4h3cck 545 21 ( ( -LRB- cord-267475-6f4h3cck 545 22 presumably presumably RB cord-267475-6f4h3cck 545 23 because because IN cord-267475-6f4h3cck 545 24 ribosomes ribosome NNS cord-267475-6f4h3cck 545 25 have have VBP cord-267475-6f4h3cck 545 26 not not RB cord-267475-6f4h3cck 545 27 yet yet RB cord-267475-6f4h3cck 545 28 reacquired reacquire VBN cord-267475-6f4h3cck 545 29 Met Met NNP cord-267475-6f4h3cck 545 30 - - HYPH cord-267475-6f4h3cck 545 31 tRNA tRNA NNP cord-267475-6f4h3cck 545 32 i i NNP cord-267475-6f4h3cck 545 33 ) ) -RRB- cord-267475-6f4h3cck 545 34 , , , cord-267475-6f4h3cck 545 35 allowing allow VBG cord-267475-6f4h3cck 545 36 reinitiation reinitiation NN cord-267475-6f4h3cck 545 37 to to TO cord-267475-6f4h3cck 545 38 occur occur VB cord-267475-6f4h3cck 545 39 farther farther RB cord-267475-6f4h3cck 545 40 downstream downstream RB cord-267475-6f4h3cck 545 41 . . . cord-267475-6f4h3cck 546 1 The the DT cord-267475-6f4h3cck 546 2 same same JJ cord-267475-6f4h3cck 546 3 mechanism mechanism NN cord-267475-6f4h3cck 546 4 might may MD cord-267475-6f4h3cck 546 5 be be VB cord-267475-6f4h3cck 546 6 invoked invoke VBN cord-267475-6f4h3cck 546 7 to to TO cord-267475-6f4h3cck 546 8 explain explain VB cord-267475-6f4h3cck 546 9 how how WRB cord-267475-6f4h3cck 546 10 an an DT cord-267475-6f4h3cck 546 11 internal internal JJ cord-267475-6f4h3cck 546 12 start start NN cord-267475-6f4h3cck 546 13 codon codon NN cord-267475-6f4h3cck 546 14 is be VBZ cord-267475-6f4h3cck 546 15 accessed access VBN cord-267475-6f4h3cck 546 16 in in IN cord-267475-6f4h3cck 546 17 miniTrpRS miniTrpRS NNP cord-267475-6f4h3cck 546 18 mRNA mRNA NNP cord-267475-6f4h3cck 546 19 ( ( -LRB- cord-267475-6f4h3cck 546 20 Wakasugi Wakasugi NNP cord-267475-6f4h3cck 546 21 et et NNP cord-267475-6f4h3cck 546 22 al al NNP cord-267475-6f4h3cck 546 23 . . NNP cord-267475-6f4h3cck 546 24 , , , cord-267475-6f4h3cck 546 25 2002 2002 CD cord-267475-6f4h3cck 546 26 ) ) -RRB- cord-267475-6f4h3cck 546 27 and and CC cord-267475-6f4h3cck 546 28 baculovirus baculovirus NNP cord-267475-6f4h3cck 546 29 IE0 IE0 NNP cord-267475-6f4h3cck 546 30 mRNA mRNA NNP cord-267475-6f4h3cck 547 1 ( ( -LRB- cord-267475-6f4h3cck 547 2 Theilmann Theilmann NNP cord-267475-6f4h3cck 547 3 et et NNP cord-267475-6f4h3cck 547 4 al al NNP cord-267475-6f4h3cck 547 5 . . NNP cord-267475-6f4h3cck 547 6 , , , cord-267475-6f4h3cck 547 7 2001 2001 CD cord-267475-6f4h3cck 547 8 ) ) -RRB- cord-267475-6f4h3cck 547 9 , , , cord-267475-6f4h3cck 547 10 and and CC cord-267475-6f4h3cck 547 11 how how WRB cord-267475-6f4h3cck 547 12 c c NNP cord-267475-6f4h3cck 547 13 - - HYPH cord-267475-6f4h3cck 547 14 myb myb NNP cord-267475-6f4h3cck 547 15 gets get VBZ cord-267475-6f4h3cck 547 16 translated translate VBN cord-267475-6f4h3cck 547 17 from from IN cord-267475-6f4h3cck 547 18 a a DT cord-267475-6f4h3cck 547 19 rearranged rearrange VBN cord-267475-6f4h3cck 547 20 transcript transcript NN cord-267475-6f4h3cck 547 21 generated generate VBN cord-267475-6f4h3cck 547 22 by by IN cord-267475-6f4h3cck 547 23 retrovirus retrovirus NN cord-267475-6f4h3cck 547 24 insertion insertion NN cord-267475-6f4h3cck 547 25 ( ( -LRB- cord-267475-6f4h3cck 547 26 Jiang Jiang NNP cord-267475-6f4h3cck 547 27 et et FW cord-267475-6f4h3cck 547 28 al al NNP cord-267475-6f4h3cck 547 29 . . NNP cord-267475-6f4h3cck 547 30 , , , cord-267475-6f4h3cck 547 31 1997 1997 CD cord-267475-6f4h3cck 547 32 ) ) -RRB- cord-267475-6f4h3cck 547 33 . . . cord-267475-6f4h3cck 548 1 In in IN cord-267475-6f4h3cck 548 2 each each DT cord-267475-6f4h3cck 548 3 of of IN cord-267475-6f4h3cck 548 4 these these DT cord-267475-6f4h3cck 548 5 mRNAs mRNAs NNPS cord-267475-6f4h3cck 548 6 , , , cord-267475-6f4h3cck 548 7 the the DT cord-267475-6f4h3cck 548 8 first first JJ cord-267475-6f4h3cck 548 9 AUG AUG NNP cord-267475-6f4h3cck 548 10 codon codon NN cord-267475-6f4h3cck 548 11 that that WDT cord-267475-6f4h3cck 548 12 follows follow VBZ cord-267475-6f4h3cck 548 13 a a DT cord-267475-6f4h3cck 548 14 small small JJ cord-267475-6f4h3cck 548 15 upORF uporf NN cord-267475-6f4h3cck 548 16 must must MD cord-267475-6f4h3cck 548 17 be be VB cord-267475-6f4h3cck 548 18 bypassed bypass VBN cord-267475-6f4h3cck 548 19 to to TO cord-267475-6f4h3cck 548 20 reach reach VB cord-267475-6f4h3cck 548 21 the the DT cord-267475-6f4h3cck 548 22 functional functional JJ cord-267475-6f4h3cck 548 23 start start NN cord-267475-6f4h3cck 548 24 codon codon NN cord-267475-6f4h3cck 548 25 downstream downstream RB cord-267475-6f4h3cck 548 26 . . . cord-267475-6f4h3cck 549 1 ( ( -LRB- cord-267475-6f4h3cck 549 2 iii iii NN cord-267475-6f4h3cck 549 3 ) ) -RRB- cord-267475-6f4h3cck 550 1 The the DT cord-267475-6f4h3cck 550 2 third third JJ cord-267475-6f4h3cck 550 3 lesson lesson NN cord-267475-6f4h3cck 550 4 from from IN cord-267475-6f4h3cck 550 5 GCN4 GCN4 NNP cord-267475-6f4h3cck 550 6 pertains pertain VBZ cord-267475-6f4h3cck 550 7 to to IN cord-267475-6f4h3cck 550 8 regulation regulation NN cord-267475-6f4h3cck 550 9 of of IN cord-267475-6f4h3cck 550 10 reinitiation reinitiation NN cord-267475-6f4h3cck 550 11 by by IN cord-267475-6f4h3cck 550 12 manipulation manipulation NN cord-267475-6f4h3cck 550 13 of of IN cord-267475-6f4h3cck 550 14 eIF2 eIF2 NNP cord-267475-6f4h3cck 550 15 levels level NNS cord-267475-6f4h3cck 550 16 . . . cord-267475-6f4h3cck 551 1 Although although IN cord-267475-6f4h3cck 551 2 hints hint NNS cord-267475-6f4h3cck 551 3 of of IN cord-267475-6f4h3cck 551 4 this this DT cord-267475-6f4h3cck 551 5 have have VBP cord-267475-6f4h3cck 551 6 been be VBN cord-267475-6f4h3cck 551 7 described describe VBN cord-267475-6f4h3cck 551 8 with with IN cord-267475-6f4h3cck 551 9 mammalian mammalian JJ cord-267475-6f4h3cck 551 10 genes gene NNS cord-267475-6f4h3cck 551 11 that that WDT cord-267475-6f4h3cck 551 12 encode encode VBP cord-267475-6f4h3cck 551 13 C C NNP cord-267475-6f4h3cck 551 14 / / SYM cord-267475-6f4h3cck 551 15 EBP ebp NN cord-267475-6f4h3cck 551 16 transcription transcription NN cord-267475-6f4h3cck 551 17 factors factor NNS cord-267475-6f4h3cck 552 1 ( ( -LRB- cord-267475-6f4h3cck 552 2 Calkhoven Calkhoven NNP cord-267475-6f4h3cck 552 3 et et NNP cord-267475-6f4h3cck 552 4 al al NNP cord-267475-6f4h3cck 552 5 . . NNP cord-267475-6f4h3cck 552 6 , , , cord-267475-6f4h3cck 552 7 2000 2000 CD cord-267475-6f4h3cck 552 8 ) ) -RRB- cord-267475-6f4h3cck 552 9 , , , cord-267475-6f4h3cck 552 10 macrophage macrophage NN cord-267475-6f4h3cck 552 11 receptor receptor NN cord-267475-6f4h3cck 552 12 protein protein NN cord-267475-6f4h3cck 553 1 CD36 CD36 NNP cord-267475-6f4h3cck 554 1 ( ( -LRB- cord-267475-6f4h3cck 554 2 Griffin Griffin NNP cord-267475-6f4h3cck 554 3 et et NNP cord-267475-6f4h3cck 554 4 al al NNP cord-267475-6f4h3cck 554 5 . . NNP cord-267475-6f4h3cck 554 6 , , , cord-267475-6f4h3cck 554 7 2001 2001 CD cord-267475-6f4h3cck 554 8 ) ) -RRB- cord-267475-6f4h3cck 554 9 and and CC cord-267475-6f4h3cck 554 10 activating activate VBG cord-267475-6f4h3cck 554 11 transcription transcription NN cord-267475-6f4h3cck 554 12 factor factor NN cord-267475-6f4h3cck 554 13 4 4 CD cord-267475-6f4h3cck 555 1 ( ( -LRB- cord-267475-6f4h3cck 555 2 Harding Harding NNP cord-267475-6f4h3cck 555 3 et et NNP cord-267475-6f4h3cck 555 4 al al NNP cord-267475-6f4h3cck 555 5 . . . cord-267475-6f4h3cck 556 1 , , , cord-267475-6f4h3cck 556 2 2000 2000 CD cord-267475-6f4h3cck 556 3 ) ) -RRB- cord-267475-6f4h3cck 556 4 , , , cord-267475-6f4h3cck 556 5 the the DT cord-267475-6f4h3cck 556 6 point point NN cord-267475-6f4h3cck 556 7 requires require VBZ cord-267475-6f4h3cck 556 8 much much RB cord-267475-6f4h3cck 556 9 more more RBR cord-267475-6f4h3cck 556 10 careful careful JJ cord-267475-6f4h3cck 556 11 study study NN cord-267475-6f4h3cck 556 12 . . . cord-267475-6f4h3cck 557 1 The the DT cord-267475-6f4h3cck 557 2 mRNAs mRNAs NNPS cord-267475-6f4h3cck 557 3 discussed discuss VBD cord-267475-6f4h3cck 557 4 in in IN cord-267475-6f4h3cck 557 5 connection connection NN cord-267475-6f4h3cck 557 6 with with IN cord-267475-6f4h3cck 557 7 Fig Fig NNP cord-267475-6f4h3cck 557 8 . . . cord-267475-6f4h3cck 558 1 3A 3A NNP cord-267475-6f4h3cck 558 2 have have VBP cord-267475-6f4h3cck 558 3 upORFs upORFs NNP cord-267475-6f4h3cck 558 4 that that WDT cord-267475-6f4h3cck 558 5 terminate terminate VB cord-267475-6f4h3cck 558 6 before before IN cord-267475-6f4h3cck 558 7 the the DT cord-267475-6f4h3cck 558 8 start start NN cord-267475-6f4h3cck 558 9 of of IN cord-267475-6f4h3cck 558 10 the the DT cord-267475-6f4h3cck 558 11 major major JJ cord-267475-6f4h3cck 558 12 coding coding NN cord-267475-6f4h3cck 558 13 domain domain NN cord-267475-6f4h3cck 558 14 , , , cord-267475-6f4h3cck 558 15 thus thus RB cord-267475-6f4h3cck 558 16 allowing allow VBG cord-267475-6f4h3cck 558 17 ( ( -LRB- cord-267475-6f4h3cck 558 18 inefficient inefficient JJ cord-267475-6f4h3cck 558 19 ) ) -RRB- cord-267475-6f4h3cck 558 20 translation translation NN cord-267475-6f4h3cck 558 21 of of IN cord-267475-6f4h3cck 558 22 the the DT cord-267475-6f4h3cck 558 23 main main JJ cord-267475-6f4h3cck 558 24 ORF ORF NNP cord-267475-6f4h3cck 558 25 by by IN cord-267475-6f4h3cck 558 26 reinitiation reinitiation NN cord-267475-6f4h3cck 558 27 . . . cord-267475-6f4h3cck 559 1 In in IN cord-267475-6f4h3cck 559 2 Fig Fig NNP cord-267475-6f4h3cck 559 3 . . . cord-267475-6f4h3cck 560 1 3B 3B NNP cord-267475-6f4h3cck 560 2 , , , cord-267475-6f4h3cck 560 3 however however RB cord-267475-6f4h3cck 560 4 , , , cord-267475-6f4h3cck 560 5 the the DT cord-267475-6f4h3cck 560 6 upORF uporf JJ cord-267475-6f4h3cck 560 7 overlaps overlap VBZ cord-267475-6f4h3cck 560 8 the the DT cord-267475-6f4h3cck 560 9 start start NN cord-267475-6f4h3cck 560 10 of of IN cord-267475-6f4h3cck 560 11 the the DT cord-267475-6f4h3cck 560 12 major major JJ cord-267475-6f4h3cck 560 13 coding coding NN cord-267475-6f4h3cck 560 14 domain domain NN cord-267475-6f4h3cck 560 15 . . . cord-267475-6f4h3cck 561 1 This this DT cord-267475-6f4h3cck 561 2 precludes preclude VBZ cord-267475-6f4h3cck 561 3 reinitiation reinitiation NN cord-267475-6f4h3cck 561 4 and and CC cord-267475-6f4h3cck 561 5 profoundly profoundly RB cord-267475-6f4h3cck 561 6 reduces reduce VBZ cord-267475-6f4h3cck 561 7 the the DT cord-267475-6f4h3cck 561 8 translational translational JJ cord-267475-6f4h3cck 561 9 yield yield NN cord-267475-6f4h3cck 561 10 . . . cord-267475-6f4h3cck 562 1 Limited limited JJ cord-267475-6f4h3cck 562 2 access access NN cord-267475-6f4h3cck 562 3 to to IN cord-267475-6f4h3cck 562 4 the the DT cord-267475-6f4h3cck 562 5 main main JJ cord-267475-6f4h3cck 562 6 ORF orf NN cord-267475-6f4h3cck 562 7 in in IN cord-267475-6f4h3cck 562 8 some some DT cord-267475-6f4h3cck 562 9 of of IN cord-267475-6f4h3cck 562 10 these these DT cord-267475-6f4h3cck 562 11 mRNAs mrna NNS cord-267475-6f4h3cck 562 12 might may MD cord-267475-6f4h3cck 562 13 be be VB cord-267475-6f4h3cck 562 14 achieved achieve VBN cord-267475-6f4h3cck 562 15 by by IN cord-267475-6f4h3cck 562 16 leaky leaky JJ cord-267475-6f4h3cck 562 17 scanning scanning NN cord-267475-6f4h3cck 562 18 , , , cord-267475-6f4h3cck 562 19 as as IN cord-267475-6f4h3cck 562 20 was be VBD cord-267475-6f4h3cck 562 21 discussed discuss VBN cord-267475-6f4h3cck 562 22 for for IN cord-267475-6f4h3cck 562 23 A a DT cord-267475-6f4h3cck 562 24 2A 2a CD cord-267475-6f4h3cck 562 25 -R -R . cord-267475-6f4h3cck 563 1 ( ( -LRB- cord-267475-6f4h3cck 563 2 Fig Fig NNP cord-267475-6f4h3cck 563 3 . . . cord-267475-6f4h3cck 563 4 2D 2D NNP cord-267475-6f4h3cck 563 5 ) ) -RRB- cord-267475-6f4h3cck 563 6 . . . cord-267475-6f4h3cck 564 1 mRNAs mRNAs NNP cord-267475-6f4h3cck 564 2 derived derive VBN cord-267475-6f4h3cck 564 3 from from IN cord-267475-6f4h3cck 564 4 the the DT cord-267475-6f4h3cck 564 5 human human JJ cord-267475-6f4h3cck 564 6 thrombopoietin thrombopoietin NNP cord-267475-6f4h3cck 564 7 ( ( -LRB- cord-267475-6f4h3cck 564 8 TPO TPO NNP cord-267475-6f4h3cck 564 9 ) ) -RRB- cord-267475-6f4h3cck 564 10 gene gene NN cord-267475-6f4h3cck 564 11 have have VBP cord-267475-6f4h3cck 564 12 structures structure NNS cord-267475-6f4h3cck 564 13 similar similar JJ cord-267475-6f4h3cck 564 14 to to IN cord-267475-6f4h3cck 564 15 that that DT cord-267475-6f4h3cck 564 16 depicted depict VBN cord-267475-6f4h3cck 564 17 in in IN cord-267475-6f4h3cck 564 18 Fig Fig NNP cord-267475-6f4h3cck 564 19 . . . cord-267475-6f4h3cck 564 20 3B 3b CD cord-267475-6f4h3cck 564 21 and and CC cord-267475-6f4h3cck 564 22 much much JJ cord-267475-6f4h3cck 564 23 can can MD cord-267475-6f4h3cck 564 24 be be VB cord-267475-6f4h3cck 564 25 learned learn VBN cord-267475-6f4h3cck 564 26 from from IN cord-267475-6f4h3cck 564 27 the the DT cord-267475-6f4h3cck 564 28 TPO TPO NNP cord-267475-6f4h3cck 564 29 story story NN cord-267475-6f4h3cck 564 30 , , , cord-267475-6f4h3cck 564 31 as as IN cord-267475-6f4h3cck 564 32 outlined outline VBN cord-267475-6f4h3cck 564 33 in in IN cord-267475-6f4h3cck 564 34 Fig Fig NNP cord-267475-6f4h3cck 564 35 . . . cord-267475-6f4h3cck 564 36 _SP cord-267475-6f4h3cck 565 1 4 4 LS cord-267475-6f4h3cck 565 2 . . . cord-267475-6f4h3cck 566 1 The the DT cord-267475-6f4h3cck 566 2 normal normal JJ cord-267475-6f4h3cck 566 3 gene gene NN cord-267475-6f4h3cck 566 4 produces produce VBZ cord-267475-6f4h3cck 566 5 a a DT cord-267475-6f4h3cck 566 6 mixture mixture NN cord-267475-6f4h3cck 566 7 of of IN cord-267475-6f4h3cck 566 8 transcripts transcript NNS cord-267475-6f4h3cck 566 9 with with IN cord-267475-6f4h3cck 566 10 different different JJ cord-267475-6f4h3cck 566 11 leader leader NN cord-267475-6f4h3cck 566 12 sequences sequence NNS cord-267475-6f4h3cck 566 13 , , , cord-267475-6f4h3cck 566 14 all all DT cord-267475-6f4h3cck 566 15 of of IN cord-267475-6f4h3cck 566 16 which which WDT cord-267475-6f4h3cck 566 17 translate translate VBP cord-267475-6f4h3cck 566 18 TPO TPO NNP cord-267475-6f4h3cck 566 19 poorly poorly RB cord-267475-6f4h3cck 566 20 because because IN cord-267475-6f4h3cck 566 21 of of IN cord-267475-6f4h3cck 566 22 an an DT cord-267475-6f4h3cck 566 23 overlapping overlapping JJ cord-267475-6f4h3cck 566 24 upORF uporf JJ cord-267475-6f4h3cck 566 25 ( ( -LRB- cord-267475-6f4h3cck 566 26 upORF7 upORF7 `` cord-267475-6f4h3cck 566 27 in in IN cord-267475-6f4h3cck 566 28 Fig Fig NNP cord-267475-6f4h3cck 566 29 . . . cord-267475-6f4h3cck 566 30 _SP cord-267475-6f4h3cck 566 31 4 4 CD cord-267475-6f4h3cck 566 32 ) ) -RRB- cord-267475-6f4h3cck 566 33 . . . cord-267475-6f4h3cck 567 1 Targeted target VBN cord-267475-6f4h3cck 567 2 mutagenesis mutagenesis NN cord-267475-6f4h3cck 567 3 ( ( -LRB- cord-267475-6f4h3cck 567 4 Ghilardi Ghilardi NNP cord-267475-6f4h3cck 567 5 et et NNP cord-267475-6f4h3cck 567 6 al al NNP cord-267475-6f4h3cck 567 7 . . NNP cord-267475-6f4h3cck 567 8 , , , cord-267475-6f4h3cck 567 9 1998 1998 CD cord-267475-6f4h3cck 567 10 ) ) -RRB- cord-267475-6f4h3cck 567 11 confirmed confirm VBD cord-267475-6f4h3cck 567 12 that that IN cord-267475-6f4h3cck 567 13 upstream upstream NN cord-267475-6f4h3cck 567 14 AUG#7 AUG#7 NNPS cord-267475-6f4h3cck 567 15 is be VBZ cord-267475-6f4h3cck 567 16 primarily primarily RB cord-267475-6f4h3cck 567 17 responsible responsible JJ cord-267475-6f4h3cck 567 18 for for IN cord-267475-6f4h3cck 567 19 blocking block VBG cord-267475-6f4h3cck 567 20 translation translation NN cord-267475-6f4h3cck 567 21 of of IN cord-267475-6f4h3cck 567 22 TPO TPO NNP cord-267475-6f4h3cck 567 23 . . . cord-267475-6f4h3cck 568 1 This this DT cord-267475-6f4h3cck 568 2 is be VBZ cord-267475-6f4h3cck 568 3 because because IN cord-267475-6f4h3cck 568 4 its -PRON- PRP$ cord-267475-6f4h3cck 568 5 near near JJ cord-267475-6f4h3cck 568 6 - - HYPH cord-267475-6f4h3cck 568 7 optimal optimal NN cord-267475-6f4h3cck 568 8 context context NN cord-267475-6f4h3cck 568 9 ( ( -LRB- cord-267475-6f4h3cck 568 10 GCCGCCUCCaugG gccgccuccaugg NN cord-267475-6f4h3cck 568 11 ) ) -RRB- cord-267475-6f4h3cck 568 12 prevents prevent VBZ cord-267475-6f4h3cck 568 13 leaky leaky JJ cord-267475-6f4h3cck 568 14 scanning scanning NN cord-267475-6f4h3cck 568 15 and and CC cord-267475-6f4h3cck 568 16 the the DT cord-267475-6f4h3cck 568 17 overlapping overlap VBG cord-267475-6f4h3cck 568 18 arrangement arrangement NN cord-267475-6f4h3cck 568 19 precludes preclude VBZ cord-267475-6f4h3cck 568 20 reinitiation reinitiation NN cord-267475-6f4h3cck 568 21 . . . cord-267475-6f4h3cck 569 1 Various various JJ cord-267475-6f4h3cck 569 2 mutations mutation NNS cord-267475-6f4h3cck 569 3 that that WDT cord-267475-6f4h3cck 569 4 restructure restructure VBP cord-267475-6f4h3cck 569 5 the the DT cord-267475-6f4h3cck 569 6 5 5 CD cord-267475-6f4h3cck 569 7 0 0 CD cord-267475-6f4h3cck 569 8 UTR UTR NNP cord-267475-6f4h3cck 569 9 in in IN cord-267475-6f4h3cck 569 10 ways way NNS cord-267475-6f4h3cck 569 11 that that WDT cord-267475-6f4h3cck 569 12 increase increase VBP cord-267475-6f4h3cck 569 13 production production NN cord-267475-6f4h3cck 569 14 of of IN cord-267475-6f4h3cck 569 15 TPO TPO NNP cord-267475-6f4h3cck 569 16 cause cause VBP cord-267475-6f4h3cck 569 17 hereditary hereditary JJ cord-267475-6f4h3cck 569 18 thrombocythemia thrombocythemia NN cord-267475-6f4h3cck 569 19 . . . cord-267475-6f4h3cck 570 1 Translation translation NN cord-267475-6f4h3cck 570 2 of of IN cord-267475-6f4h3cck 570 3 TPO TPO NNP cord-267475-6f4h3cck 570 4 normally normally RB cord-267475-6f4h3cck 570 5 initiates initiate VBZ cord-267475-6f4h3cck 570 6 at at IN cord-267475-6f4h3cck 570 7 AUG#8 AUG#8 NNPS cord-267475-6f4h3cck 570 8 in in IN cord-267475-6f4h3cck 570 9 exon exon NN cord-267475-6f4h3cck 570 10 3 3 CD cord-267475-6f4h3cck 570 11 , , , cord-267475-6f4h3cck 570 12 but but CC cord-267475-6f4h3cck 570 13 a a DT cord-267475-6f4h3cck 570 14 splice splice NN cord-267475-6f4h3cck 570 15 - - HYPH cord-267475-6f4h3cck 570 16 site site NN cord-267475-6f4h3cck 570 17 mutation mutation NN cord-267475-6f4h3cck 570 18 that that WDT cord-267475-6f4h3cck 570 19 causes cause VBZ cord-267475-6f4h3cck 570 20 deletion deletion NN cord-267475-6f4h3cck 570 21 of of IN cord-267475-6f4h3cck 570 22 exon exon NN cord-267475-6f4h3cck 570 23 3 3 CD cord-267475-6f4h3cck 570 24 causes cause NNS cord-267475-6f4h3cck 570 25 initiation initiation NN cord-267475-6f4h3cck 570 26 to to TO cord-267475-6f4h3cck 570 27 shift shift VB cord-267475-6f4h3cck 570 28 to to IN cord-267475-6f4h3cck 570 29 a a DT cord-267475-6f4h3cck 570 30 previously previously RB cord-267475-6f4h3cck 570 31 silent silent JJ cord-267475-6f4h3cck 570 32 inframe inframe NN cord-267475-6f4h3cck 570 33 codon codon NN cord-267475-6f4h3cck 570 34 ( ( -LRB- cord-267475-6f4h3cck 570 35 AUG#9 AUG#9 NNP cord-267475-6f4h3cck 570 36 ) ) -RRB- cord-267475-6f4h3cck 570 37 in in IN cord-267475-6f4h3cck 570 38 exon exon NN cord-267475-6f4h3cck 570 39 4 4 CD cord-267475-6f4h3cck 570 40 ; ; : cord-267475-6f4h3cck 570 41 this this DT cord-267475-6f4h3cck 570 42 is be VBZ cord-267475-6f4h3cck 570 43 diagrammed diagram VBN cord-267475-6f4h3cck 570 44 in in IN cord-267475-6f4h3cck 570 45 the the DT cord-267475-6f4h3cck 570 46 center center NN cord-267475-6f4h3cck 570 47 of of IN cord-267475-6f4h3cck 570 48 Fig Fig NNP cord-267475-6f4h3cck 570 49 . . . cord-267475-6f4h3cck 571 1 4 4 LS cord-267475-6f4h3cck 571 2 . . . cord-267475-6f4h3cck 572 1 The the DT cord-267475-6f4h3cck 572 2 resulting result VBG cord-267475-6f4h3cck 572 3 truncated truncated JJ cord-267475-6f4h3cck 572 4 form form NN cord-267475-6f4h3cck 572 5 of of IN cord-267475-6f4h3cck 572 6 TPO TPO NNP cord-267475-6f4h3cck 572 7 lacks lack VBZ cord-267475-6f4h3cck 572 8 only only RB cord-267475-6f4h3cck 572 9 the the DT cord-267475-6f4h3cck 572 10 first first JJ cord-267475-6f4h3cck 572 11 four four CD cord-267475-6f4h3cck 572 12 amino amino NN cord-267475-6f4h3cck 572 13 acids acid NNS cord-267475-6f4h3cck 572 14 and and CC cord-267475-6f4h3cck 572 15 appears appear VBZ cord-267475-6f4h3cck 572 16 to to TO cord-267475-6f4h3cck 572 17 function function VB cord-267475-6f4h3cck 572 18 normally normally RB cord-267475-6f4h3cck 572 19 . . . cord-267475-6f4h3cck 573 1 The the DT cord-267475-6f4h3cck 573 2 problem problem NN cord-267475-6f4h3cck 573 3 -the -the DT cord-267475-6f4h3cck 573 4 cause cause NN cord-267475-6f4h3cck 573 5 of of IN cord-267475-6f4h3cck 573 6 the the DT cord-267475-6f4h3cck 573 7 pathology pathology NN cord-267475-6f4h3cck 573 8 -is -is : cord-267475-6f4h3cck 573 9 that that IN cord-267475-6f4h3cck 573 10 the the DT cord-267475-6f4h3cck 573 11 mutation mutation NN cord-267475-6f4h3cck 573 12 greatly greatly RB cord-267475-6f4h3cck 573 13 increases increase VBZ cord-267475-6f4h3cck 573 14 translation translation NN cord-267475-6f4h3cck 573 15 of of IN cord-267475-6f4h3cck 573 16 TPO TPO NNP cord-267475-6f4h3cck 573 17 by by IN cord-267475-6f4h3cck 573 18 removing remove VBG cord-267475-6f4h3cck 573 19 the the DT cord-267475-6f4h3cck 573 20 inhibitory inhibitory JJ cord-267475-6f4h3cck 573 21 upORF7 upORF7 NNP cord-267475-6f4h3cck 573 22 . . . cord-267475-6f4h3cck 574 1 In in IN cord-267475-6f4h3cck 574 2 two two CD cord-267475-6f4h3cck 574 3 other other JJ cord-267475-6f4h3cck 574 4 families family NNS cord-267475-6f4h3cck 574 5 affected affect VBN cord-267475-6f4h3cck 574 6 with with IN cord-267475-6f4h3cck 574 7 hereditary hereditary JJ cord-267475-6f4h3cck 574 8 thrombocythemia thrombocythemia NN cord-267475-6f4h3cck 574 9 , , , cord-267475-6f4h3cck 574 10 production production NN cord-267475-6f4h3cck 574 11 of of IN cord-267475-6f4h3cck 574 12 TPO TPO NNP cord-267475-6f4h3cck 574 13 is be VBZ cord-267475-6f4h3cck 574 14 elevated elevate VBN cord-267475-6f4h3cck 574 15 by by IN cord-267475-6f4h3cck 574 16 mutations mutation NNS cord-267475-6f4h3cck 574 17 that that WDT cord-267475-6f4h3cck 574 18 restructure restructure VBP cord-267475-6f4h3cck 574 19 upORF7 uporf7 CD cord-267475-6f4h3cck 574 20 . . . cord-267475-6f4h3cck 575 1 In in IN cord-267475-6f4h3cck 575 2 one one CD cord-267475-6f4h3cck 575 3 case case NN cord-267475-6f4h3cck 575 4 , , , cord-267475-6f4h3cck 575 5 deletion deletion NN cord-267475-6f4h3cck 575 6 of of IN cord-267475-6f4h3cck 575 7 a a DT cord-267475-6f4h3cck 575 8 G g NN cord-267475-6f4h3cck 575 9 residue residue NN cord-267475-6f4h3cck 575 10 shifts shift NNS cord-267475-6f4h3cck 575 11 upORF7 uporf7 XX cord-267475-6f4h3cck 575 12 into into IN cord-267475-6f4h3cck 575 13 the the DT cord-267475-6f4h3cck 575 14 same same JJ cord-267475-6f4h3cck 575 15 reading reading NN cord-267475-6f4h3cck 575 16 frame frame NN cord-267475-6f4h3cck 575 17 as as IN cord-267475-6f4h3cck 575 18 TPO TPO NNP cord-267475-6f4h3cck 575 19 , , , cord-267475-6f4h3cck 575 20 thereby thereby RB cord-267475-6f4h3cck 575 21 causing cause VBG cord-267475-6f4h3cck 575 22 overproduction overproduction NN cord-267475-6f4h3cck 575 23 of of IN cord-267475-6f4h3cck 575 24 an an DT cord-267475-6f4h3cck 575 25 elongated elongated JJ cord-267475-6f4h3cck 575 26 form form NN cord-267475-6f4h3cck 575 27 of of IN cord-267475-6f4h3cck 575 28 TPO TPO NNP cord-267475-6f4h3cck 575 29 initiated initiate VBN cord-267475-6f4h3cck 575 30 from from IN cord-267475-6f4h3cck 575 31 AUG#7 AUG#7 NNP cord-267475-6f4h3cck 575 32 Kondo Kondo NNP cord-267475-6f4h3cck 575 33 et et NNP cord-267475-6f4h3cck 575 34 al al NNP cord-267475-6f4h3cck 575 35 . . NNP cord-267475-6f4h3cck 575 36 , , , cord-267475-6f4h3cck 575 37 1998 1998 CD cord-267475-6f4h3cck 575 38 ) ) -RRB- cord-267475-6f4h3cck 575 39 . . . cord-267475-6f4h3cck 576 1 In in IN cord-267475-6f4h3cck 576 2 the the DT cord-267475-6f4h3cck 576 3 other other JJ cord-267475-6f4h3cck 576 4 case case NN cord-267475-6f4h3cck 576 5 , , , cord-267475-6f4h3cck 576 6 a a DT cord-267475-6f4h3cck 576 7 G g NN cord-267475-6f4h3cck 576 8 ! ! . cord-267475-6f4h3cck 577 1 T T NNP cord-267475-6f4h3cck 577 2 mutation mutation NN cord-267475-6f4h3cck 577 3 creates create VBZ cord-267475-6f4h3cck 577 4 a a DT cord-267475-6f4h3cck 577 5 terminator terminator NN cord-267475-6f4h3cck 577 6 codon codon NN cord-267475-6f4h3cck 577 7 within within IN cord-267475-6f4h3cck 577 8 upORF7 upORF7 NNP cord-267475-6f4h3cck 577 9 and and CC cord-267475-6f4h3cck 577 10 this this DT cord-267475-6f4h3cck 577 11 shortening shortening NN cord-267475-6f4h3cck 577 12 of of IN cord-267475-6f4h3cck 577 13 the the DT cord-267475-6f4h3cck 577 14 ORF ORF NNP cord-267475-6f4h3cck 577 15 , , , cord-267475-6f4h3cck 577 16 which which WDT cord-267475-6f4h3cck 577 17 now now RB cord-267475-6f4h3cck 577 18 terminates terminate VBZ cord-267475-6f4h3cck 577 19 31 31 CD cord-267475-6f4h3cck 577 20 nt nt RB cord-267475-6f4h3cck 577 21 before before IN cord-267475-6f4h3cck 577 22 AUG#8 AUG#8 NNPS cord-267475-6f4h3cck 577 23 , , , cord-267475-6f4h3cck 577 24 enables enable VBZ cord-267475-6f4h3cck 577 25 efficient efficient JJ cord-267475-6f4h3cck 577 26 reinitiation reinitiation NN cord-267475-6f4h3cck 577 27 at at IN cord-267475-6f4h3cck 577 28 AUG#8 AUG#8 NNPS cord-267475-6f4h3cck 577 29 . . . cord-267475-6f4h3cck 578 1 These these DT cord-267475-6f4h3cck 578 2 insightful insightful JJ cord-267475-6f4h3cck 578 3 studies study NNS cord-267475-6f4h3cck 578 4 of of IN cord-267475-6f4h3cck 578 5 TPO TPO NNP cord-267475-6f4h3cck 578 6 expression expression NN cord-267475-6f4h3cck 578 7 make make VB cord-267475-6f4h3cck 578 8 two two CD cord-267475-6f4h3cck 578 9 important important JJ cord-267475-6f4h3cck 578 10 points point NNS cord-267475-6f4h3cck 578 11 : : : cord-267475-6f4h3cck 578 12 ( ( -LRB- cord-267475-6f4h3cck 578 13 i i NN cord-267475-6f4h3cck 578 14 ) ) -RRB- cord-267475-6f4h3cck 579 1 the the DT cord-267475-6f4h3cck 579 2 bulk bulk NN cord-267475-6f4h3cck 579 3 of of IN cord-267475-6f4h3cck 579 4 the the DT cord-267475-6f4h3cck 579 5 transcripts transcript NNS cord-267475-6f4h3cck 579 6 produced produce VBN cord-267475-6f4h3cck 579 7 by by IN cord-267475-6f4h3cck 579 8 the the DT cord-267475-6f4h3cck 579 9 wild wild JJ cord-267475-6f4h3cck 579 10 type type NN cord-267475-6f4h3cck 579 11 gene gene NN cord-267475-6f4h3cck 579 12 are be VBP cord-267475-6f4h3cck 579 13 virtually virtually RB cord-267475-6f4h3cck 579 14 untranslatable untranslatable JJ cord-267475-6f4h3cck 579 15 ; ; : cord-267475-6f4h3cck 579 16 and and CC cord-267475-6f4h3cck 579 17 ( ( -LRB- cord-267475-6f4h3cck 579 18 ii ii NN cord-267475-6f4h3cck 579 19 ) ) -RRB- cord-267475-6f4h3cck 579 20 it -PRON- PRP cord-267475-6f4h3cck 579 21 is be VBZ cord-267475-6f4h3cck 579 22 necessary necessary JJ cord-267475-6f4h3cck 579 23 for for IN cord-267475-6f4h3cck 579 24 this this DT cord-267475-6f4h3cck 579 25 potent potent JJ cord-267475-6f4h3cck 579 26 cytokine cytokine NN cord-267475-6f4h3cck 579 27 to to TO cord-267475-6f4h3cck 579 28 be be VB cord-267475-6f4h3cck 579 29 translated translate VBN cord-267475-6f4h3cck 579 30 poorly poorly RB cord-267475-6f4h3cck 579 31 ; ; : cord-267475-6f4h3cck 579 32 overproduction overproduction NN cord-267475-6f4h3cck 579 33 results result NNS cord-267475-6f4h3cck 579 34 in in IN cord-267475-6f4h3cck 579 35 disease disease NN cord-267475-6f4h3cck 579 36 . . . cord-267475-6f4h3cck 580 1 With with IN cord-267475-6f4h3cck 580 2 TPO TPO NNP cord-267475-6f4h3cck 580 3 as as IN cord-267475-6f4h3cck 580 4 precedent precedent NN cord-267475-6f4h3cck 580 5 , , , cord-267475-6f4h3cck 580 6 one one CD cord-267475-6f4h3cck 580 7 suspects suspect NNS cord-267475-6f4h3cck 580 8 that that IN cord-267475-6f4h3cck 580 9 in in IN cord-267475-6f4h3cck 580 10 other other JJ cord-267475-6f4h3cck 580 11 cases case NNS cord-267475-6f4h3cck 580 12 where where WRB cord-267475-6f4h3cck 580 13 -despite -despite PDT cord-267475-6f4h3cck 580 14 the the DT cord-267475-6f4h3cck 580 15 production production NN cord-267475-6f4h3cck 580 16 of of IN cord-267475-6f4h3cck 580 17 alternative alternative JJ cord-267475-6f4h3cck 580 18 leader leader NN cord-267475-6f4h3cck 580 19 sequences sequence NNS cord-267475-6f4h3cck 580 20 -it -it : cord-267475-6f4h3cck 580 21 is be VBZ cord-267475-6f4h3cck 580 22 hard hard JJ cord-267475-6f4h3cck 580 23 to to TO cord-267475-6f4h3cck 580 24 find find VB cord-267475-6f4h3cck 580 25 even even RB cord-267475-6f4h3cck 580 26 one one CD cord-267475-6f4h3cck 580 27 form form NN cord-267475-6f4h3cck 580 28 of of IN cord-267475-6f4h3cck 580 29 mRNA mrna NN cord-267475-6f4h3cck 580 30 devoid devoid JJ cord-267475-6f4h3cck 580 31 of of IN cord-267475-6f4h3cck 580 32 upstream upstream JJ cord-267475-6f4h3cck 580 33 AUG AUG NNP cord-267475-6f4h3cck 580 34 codons codon NNS cord-267475-6f4h3cck 580 35 ( ( -LRB- cord-267475-6f4h3cck 580 36 e.g. e.g. IN cord-267475-6f4h3cck 580 37 Larsen Larsen NNP cord-267475-6f4h3cck 580 38 et et NNP cord-267475-6f4h3cck 580 39 al al NNP cord-267475-6f4h3cck 580 40 . . NNP cord-267475-6f4h3cck 580 41 , , , cord-267475-6f4h3cck 580 42 2002 2002 CD cord-267475-6f4h3cck 580 43 ; ; : cord-267475-6f4h3cck 581 1 Lee Lee NNP cord-267475-6f4h3cck 581 2 et et NNP cord-267475-6f4h3cck 581 3 al al NNP cord-267475-6f4h3cck 581 4 . . NNP cord-267475-6f4h3cck 581 5 , , , cord-267475-6f4h3cck 581 6 1999 1999 CD cord-267475-6f4h3cck 581 7 ; ; : cord-267475-6f4h3cck 581 8 Pecci Pecci NNP cord-267475-6f4h3cck 581 9 et et NNP cord-267475-6f4h3cck 581 10 al al NNP cord-267475-6f4h3cck 581 11 . . NNP cord-267475-6f4h3cck 581 12 , , , cord-267475-6f4h3cck 581 13 2001 2001 CD cord-267475-6f4h3cck 581 14 ; ; : cord-267475-6f4h3cck 582 1 Peterson Peterson NNP cord-267475-6f4h3cck 582 2 and and CC cord-267475-6f4h3cck 582 3 Morris Morris NNP cord-267475-6f4h3cck 582 4 , , , cord-267475-6f4h3cck 582 5 2000 2000 CD cord-267475-6f4h3cck 582 6 ; ; : cord-267475-6f4h3cck 582 7 Wang Wang NNP cord-267475-6f4h3cck 582 8 et et NNP cord-267475-6f4h3cck 582 9 al al NNP cord-267475-6f4h3cck 582 10 . . NNP cord-267475-6f4h3cck 582 11 , , , cord-267475-6f4h3cck 582 12 1999 1999 CD cord-267475-6f4h3cck 582 13 ) ) -RRB- cord-267475-6f4h3cck 582 14 , , , cord-267475-6f4h3cck 582 15 the the DT cord-267475-6f4h3cck 582 16 goal goal NN cord-267475-6f4h3cck 582 17 is be VBZ cord-267475-6f4h3cck 582 18 to to TO cord-267475-6f4h3cck 582 19 ensure ensure VB cord-267475-6f4h3cck 582 20 that that DT cord-267475-6f4h3cck 582 21 translation translation NN cord-267475-6f4h3cck 582 22 is be VBZ cord-267475-6f4h3cck 582 23 very very RB cord-267475-6f4h3cck 582 24 , , , cord-267475-6f4h3cck 582 25 very very RB cord-267475-6f4h3cck 582 26 inefficient inefficient JJ cord-267475-6f4h3cck 582 27 . . . cord-267475-6f4h3cck 583 1 The the DT cord-267475-6f4h3cck 583 2 wig-1 wig-1 NNP cord-267475-6f4h3cck 583 3 growth growth NN cord-267475-6f4h3cck 583 4 - - HYPH cord-267475-6f4h3cck 583 5 regulatory regulatory JJ cord-267475-6f4h3cck 583 6 gene gene NN cord-267475-6f4h3cck 583 7 might may MD cord-267475-6f4h3cck 583 8 be be VB cord-267475-6f4h3cck 583 9 another another DT cord-267475-6f4h3cck 583 10 example example NN cord-267475-6f4h3cck 583 11 : : : cord-267475-6f4h3cck 583 12 an an DT cord-267475-6f4h3cck 583 13 overlapping overlap VBG cord-267475-6f4h3cck 583 14 upORF uporf JJ cord-267475-6f4h3cck 583 15 initiates initiate NNS cord-267475-6f4h3cck 583 16 from from IN cord-267475-6f4h3cck 583 17 a a DT cord-267475-6f4h3cck 583 18 strong strong JJ cord-267475-6f4h3cck 583 19 AUG AUG NNP cord-267475-6f4h3cck 583 20 codon codon NN cord-267475-6f4h3cck 583 21 , , , cord-267475-6f4h3cck 583 22 while while IN cord-267475-6f4h3cck 583 23 the the DT cord-267475-6f4h3cck 583 24 wig-1 wig-1 NNP cord-267475-6f4h3cck 583 25 start start NN cord-267475-6f4h3cck 583 26 codon codon NN cord-267475-6f4h3cck 583 27 itself -PRON- PRP cord-267475-6f4h3cck 583 28 is be VBZ cord-267475-6f4h3cck 583 29 weak weak JJ cord-267475-6f4h3cck 583 30 , , , cord-267475-6f4h3cck 583 31 and and CC cord-267475-6f4h3cck 583 32 these these DT cord-267475-6f4h3cck 583 33 distinctive distinctive JJ cord-267475-6f4h3cck 583 34 features feature NNS cord-267475-6f4h3cck 583 35 are be VBP cord-267475-6f4h3cck 583 36 conserved conserve VBN cord-267475-6f4h3cck 583 37 between between IN cord-267475-6f4h3cck 583 38 the the DT cord-267475-6f4h3cck 583 39 human human JJ cord-267475-6f4h3cck 583 40 and and CC cord-267475-6f4h3cck 583 41 mouse mouse NN cord-267475-6f4h3cck 583 42 genes gene NNS cord-267475-6f4h3cck 583 43 ( ( -LRB- cord-267475-6f4h3cck 583 44 Hellborg Hellborg NNP cord-267475-6f4h3cck 583 45 et et FW cord-267475-6f4h3cck 583 46 al al NNP cord-267475-6f4h3cck 583 47 . . NNP cord-267475-6f4h3cck 583 48 , , , cord-267475-6f4h3cck 583 49 2001 2001 CD cord-267475-6f4h3cck 583 50 ) ) -RRB- cord-267475-6f4h3cck 583 51 . . . cord-267475-6f4h3cck 584 1 Whereas whereas IN cord-267475-6f4h3cck 584 2 an an DT cord-267475-6f4h3cck 584 3 overlapping overlap VBG cord-267475-6f4h3cck 584 4 upORF uporf JJ cord-267475-6f4h3cck 584 5 functions function NNS cord-267475-6f4h3cck 584 6 simply simply RB cord-267475-6f4h3cck 584 7 to to IN cord-267475-6f4h3cck 584 8 down down RB cord-267475-6f4h3cck 584 9 - - HYPH cord-267475-6f4h3cck 584 10 modulate modulate VB cord-267475-6f4h3cck 584 11 translation translation NN cord-267475-6f4h3cck 584 12 in in IN cord-267475-6f4h3cck 584 13 the the DT cord-267475-6f4h3cck 584 14 examples example NNS cord-267475-6f4h3cck 584 15 depicted depict VBN cord-267475-6f4h3cck 584 16 in in IN cord-267475-6f4h3cck 584 17 Fig Fig NNP cord-267475-6f4h3cck 584 18 . . . cord-267475-6f4h3cck 584 19 _SP cord-267475-6f4h3cck 585 1 3B 3B NNP cord-267475-6f4h3cck 585 2 , , , cord-267475-6f4h3cck 585 3 with with IN cord-267475-6f4h3cck 585 4 the the DT cord-267475-6f4h3cck 585 5 mRNAs mRNAs NNPS cord-267475-6f4h3cck 585 6 in in IN cord-267475-6f4h3cck 585 7 Fig Fig NNP cord-267475-6f4h3cck 585 8 . . . cord-267475-6f4h3cck 586 1 3C 3C NNP cord-267475-6f4h3cck 586 2 the the DT cord-267475-6f4h3cck 586 3 overlapping overlap VBG cord-267475-6f4h3cck 586 4 upORF uporf JJ cord-267475-6f4h3cck 586 5 qualitatively qualitatively RB cord-267475-6f4h3cck 586 6 affects affect VBZ cord-267475-6f4h3cck 586 7 the the DT cord-267475-6f4h3cck 586 8 protein protein NN cord-267475-6f4h3cck 586 9 output output NN cord-267475-6f4h3cck 586 10 . . . cord-267475-6f4h3cck 587 1 Ribosomes ribosome NNS cord-267475-6f4h3cck 587 2 that that WDT cord-267475-6f4h3cck 587 3 translate translate VBP cord-267475-6f4h3cck 587 4 the the DT cord-267475-6f4h3cck 587 5 upORF upORF NNP cord-267475-6f4h3cck 587 6 thereby thereby RB cord-267475-6f4h3cck 587 7 miss miss VB cord-267475-6f4h3cck 587 8 the the DT cord-267475-6f4h3cck 587 9 first first JJ cord-267475-6f4h3cck 587 10 in in IN cord-267475-6f4h3cck 587 11 - - HYPH cord-267475-6f4h3cck 587 12 frame frame NN cord-267475-6f4h3cck 587 13 AUG AUG NNP cord-267475-6f4h3cck 587 14 codon codon NN cord-267475-6f4h3cck 587 15 but but CC cord-267475-6f4h3cck 587 16 proceed proceed VB cord-267475-6f4h3cck 587 17 to to TO cord-267475-6f4h3cck 587 18 reinitiate reinitiate VB cord-267475-6f4h3cck 587 19 at at IN cord-267475-6f4h3cck 587 20 another another DT cord-267475-6f4h3cck 587 21 start start NN cord-267475-6f4h3cck 588 1 codon codon NNP cord-267475-6f4h3cck 588 2 Fig Fig NNP cord-267475-6f4h3cck 588 3 . . . cord-267475-6f4h3cck 589 1 4 4 LS cord-267475-6f4h3cck 589 2 . . . cord-267475-6f4h3cck 590 1 A a DT cord-267475-6f4h3cck 590 2 low low JJ cord-267475-6f4h3cck 590 3 - - HYPH cord-267475-6f4h3cck 590 4 level level NN cord-267475-6f4h3cck 590 5 reinitiation reinitiation NN cord-267475-6f4h3cck 590 6 mechanism mechanism NN cord-267475-6f4h3cck 590 7 normally normally RB cord-267475-6f4h3cck 590 8 prevents prevent VBZ cord-267475-6f4h3cck 590 9 overproduction overproduction NN cord-267475-6f4h3cck 590 10 of of IN cord-267475-6f4h3cck 590 11 TPO TPO NNP cord-267475-6f4h3cck 590 12 . . . cord-267475-6f4h3cck 591 1 Translational translational JJ cord-267475-6f4h3cck 591 2 yields yield NNS cord-267475-6f4h3cck 591 3 from from IN cord-267475-6f4h3cck 591 4 various various JJ cord-267475-6f4h3cck 591 5 forms form NNS cord-267475-6f4h3cck 591 6 of of IN cord-267475-6f4h3cck 591 7 TPO TPO NNP cord-267475-6f4h3cck 591 8 mRNA mrna NN cord-267475-6f4h3cck 591 9 in in IN cord-267475-6f4h3cck 591 10 transfected transfecte VBN cord-267475-6f4h3cck 591 11 COS cos NN cord-267475-6f4h3cck 591 12 cells cell NNS cord-267475-6f4h3cck 591 13 ( ( -LRB- cord-267475-6f4h3cck 591 14 far far RB cord-267475-6f4h3cck 591 15 right right JJ cord-267475-6f4h3cck 591 16 column column NN cord-267475-6f4h3cck 591 17 ) ) -RRB- cord-267475-6f4h3cck 591 18 are be VBP cord-267475-6f4h3cck 591 19 expressed express VBN cord-267475-6f4h3cck 591 20 relative relative JJ cord-267475-6f4h3cck 591 21 to to IN cord-267475-6f4h3cck 591 22 a a DT cord-267475-6f4h3cck 591 23 control control NN cord-267475-6f4h3cck 591 24 transcript transcript NN cord-267475-6f4h3cck 591 25 that that WDT cord-267475-6f4h3cck 591 26 has have VBZ cord-267475-6f4h3cck 591 27 a a DT cord-267475-6f4h3cck 591 28 short short JJ cord-267475-6f4h3cck 591 29 , , , cord-267475-6f4h3cck 591 30 unencumbered unencumbered JJ cord-267475-6f4h3cck 591 31 5 5 CD cord-267475-6f4h3cck 591 32 0 0 CD cord-267475-6f4h3cck 591 33 UTR UTR NNP cord-267475-6f4h3cck 591 34 . . . cord-267475-6f4h3cck 592 1 P1 P1 NNP cord-267475-6f4h3cck 592 2 and and CC cord-267475-6f4h3cck 592 3 P2 P2 NNP cord-267475-6f4h3cck 592 4 are be VBP cord-267475-6f4h3cck 592 5 alternative alternative JJ cord-267475-6f4h3cck 592 6 promoters promoter NNS cord-267475-6f4h3cck 592 7 ; ; : cord-267475-6f4h3cck 592 8 a a DT cord-267475-6f4h3cck 592 9 cluster cluster NN cord-267475-6f4h3cck 592 10 of of IN cord-267475-6f4h3cck 592 11 arrows arrow NNS cord-267475-6f4h3cck 592 12 indicates indicate VBZ cord-267475-6f4h3cck 592 13 that that IN cord-267475-6f4h3cck 592 14 P2 P2 NNP cord-267475-6f4h3cck 592 15 produces produce VBZ cord-267475-6f4h3cck 592 16 staggered stagger VBN cord-267475-6f4h3cck 592 17 start start NN cord-267475-6f4h3cck 592 18 sites site NNS cord-267475-6f4h3cck 592 19 . . . cord-267475-6f4h3cck 593 1 The the DT cord-267475-6f4h3cck 593 2 TPO TPO NNP cord-267475-6f4h3cck 593 3 coding coding NN cord-267475-6f4h3cck 593 4 domain domain NN cord-267475-6f4h3cck 593 5 ( ( -LRB- cord-267475-6f4h3cck 593 6 horizontal horizontal JJ cord-267475-6f4h3cck 593 7 black black JJ cord-267475-6f4h3cck 593 8 bar bar NN cord-267475-6f4h3cck 593 9 ) ) -RRB- cord-267475-6f4h3cck 593 10 begins begin VBZ cord-267475-6f4h3cck 593 11 at at IN cord-267475-6f4h3cck 593 12 an an DT cord-267475-6f4h3cck 593 13 AUG AUG NNP cord-267475-6f4h3cck 593 14 codon codon NN cord-267475-6f4h3cck 593 15 which which WDT cord-267475-6f4h3cck 593 16 is be VBZ cord-267475-6f4h3cck 593 17 labeled label VBN cord-267475-6f4h3cck 593 18 # # $ cord-267475-6f4h3cck 593 19 8 8 CD cord-267475-6f4h3cck 593 20 because because IN cord-267475-6f4h3cck 593 21 , , , cord-267475-6f4h3cck 593 22 in in IN cord-267475-6f4h3cck 593 23 the the DT cord-267475-6f4h3cck 593 24 longest long JJS cord-267475-6f4h3cck 593 25 form form NN cord-267475-6f4h3cck 593 26 of of IN cord-267475-6f4h3cck 593 27 mRNA mrna NN cord-267475-6f4h3cck 593 28 ( ( -LRB- cord-267475-6f4h3cck 593 29 line line NN cord-267475-6f4h3cck 593 30 1 1 CD cord-267475-6f4h3cck 593 31 ) ) -RRB- cord-267475-6f4h3cck 593 32 , , , cord-267475-6f4h3cck 593 33 it -PRON- PRP cord-267475-6f4h3cck 593 34 is be VBZ cord-267475-6f4h3cck 593 35 preceded precede VBN cord-267475-6f4h3cck 593 36 by by IN cord-267475-6f4h3cck 593 37 seven seven CD cord-267475-6f4h3cck 593 38 AUG AUG NNP cord-267475-6f4h3cck 593 39 codons codon NNS cord-267475-6f4h3cck 593 40 that that WDT cord-267475-6f4h3cck 593 41 initiate initiate VBP cord-267475-6f4h3cck 593 42 small small JJ cord-267475-6f4h3cck 593 43 upORFs uporfs NN cord-267475-6f4h3cck 593 44 . . . cord-267475-6f4h3cck 594 1 Superscript superscript NN cord-267475-6f4h3cck 594 2 letters letter NNS cord-267475-6f4h3cck 594 3 indicate indicate VBP cord-267475-6f4h3cck 594 4 whether whether IN cord-267475-6f4h3cck 594 5 each each DT cord-267475-6f4h3cck 594 6 upstream upstream JJ cord-267475-6f4h3cck 594 7 AUG AUG NNP cord-267475-6f4h3cck 594 8 resides reside VBZ cord-267475-6f4h3cck 594 9 in in IN cord-267475-6f4h3cck 594 10 a a DT cord-267475-6f4h3cck 594 11 strong strong JJ cord-267475-6f4h3cck 594 12 ( ( -LRB- cord-267475-6f4h3cck 594 13 S s NN cord-267475-6f4h3cck 594 14 ) ) -RRB- cord-267475-6f4h3cck 594 15 or or CC cord-267475-6f4h3cck 594 16 weak weak JJ cord-267475-6f4h3cck 594 17 ( ( -LRB- cord-267475-6f4h3cck 594 18 W w NN cord-267475-6f4h3cck 594 19 ) ) -RRB- cord-267475-6f4h3cck 594 20 context context NN cord-267475-6f4h3cck 594 21 and and CC cord-267475-6f4h3cck 594 22 horizontal horizontal JJ cord-267475-6f4h3cck 594 23 blue blue JJ cord-267475-6f4h3cck 594 24 lines line NNS cord-267475-6f4h3cck 594 25 depict depict VBP cord-267475-6f4h3cck 594 26 the the DT cord-267475-6f4h3cck 594 27 approximate approximate JJ cord-267475-6f4h3cck 594 28 length length NN cord-267475-6f4h3cck 594 29 and and CC cord-267475-6f4h3cck 594 30 arrangement arrangement NN cord-267475-6f4h3cck 594 31 of of IN cord-267475-6f4h3cck 594 32 the the DT cord-267475-6f4h3cck 594 33 upORFs uporfs NN cord-267475-6f4h3cck 594 34 . . . cord-267475-6f4h3cck 595 1 Vertical vertical JJ cord-267475-6f4h3cck 595 2 lines line NNS cord-267475-6f4h3cck 595 3 demarcate demarcate VBP cord-267475-6f4h3cck 595 4 the the DT cord-267475-6f4h3cck 595 5 boundaries boundary NNS cord-267475-6f4h3cck 595 6 of of IN cord-267475-6f4h3cck 595 7 exons exon NNS cord-267475-6f4h3cck 595 8 ; ; : cord-267475-6f4h3cck 595 9 carets caret NNS cord-267475-6f4h3cck 595 10 depict depict VBP cord-267475-6f4h3cck 595 11 the the DT cord-267475-6f4h3cck 595 12 introns intron NNS cord-267475-6f4h3cck 595 13 in in IN cord-267475-6f4h3cck 595 14 alternatively alternatively RB cord-267475-6f4h3cck 595 15 spliced splice VBN cord-267475-6f4h3cck 595 16 transcripts transcript NNS cord-267475-6f4h3cck 595 17 . . . cord-267475-6f4h3cck 596 1 Only only RB cord-267475-6f4h3cck 596 2 the the DT cord-267475-6f4h3cck 596 3 beginning beginning NN cord-267475-6f4h3cck 596 4 of of IN cord-267475-6f4h3cck 596 5 the the DT cord-267475-6f4h3cck 596 6 TPO TPO NNP cord-267475-6f4h3cck 596 7 coding coding NN cord-267475-6f4h3cck 596 8 domain domain NN cord-267475-6f4h3cck 596 9 ( ( -LRB- cord-267475-6f4h3cck 596 10 exons exon NNS cord-267475-6f4h3cck 596 11 3 3 CD cord-267475-6f4h3cck 596 12 -7 -7 CD cord-267475-6f4h3cck 596 13 ) ) -RRB- cord-267475-6f4h3cck 596 14 is be VBZ cord-267475-6f4h3cck 596 15 shown show VBN cord-267475-6f4h3cck 596 16 . . . cord-267475-6f4h3cck 597 1 The the DT cord-267475-6f4h3cck 597 2 key key JJ cord-267475-6f4h3cck 597 3 point point NN cord-267475-6f4h3cck 597 4 is be VBZ cord-267475-6f4h3cck 597 5 that that IN cord-267475-6f4h3cck 597 6 the the DT cord-267475-6f4h3cck 597 7 normal normal JJ cord-267475-6f4h3cck 597 8 set set NN cord-267475-6f4h3cck 597 9 of of IN cord-267475-6f4h3cck 597 10 transcripts transcript NNS cord-267475-6f4h3cck 597 11 supports support VBZ cord-267475-6f4h3cck 597 12 translation translation NN cord-267475-6f4h3cck 597 13 poorly poorly RB cord-267475-6f4h3cck 597 14 because because IN cord-267475-6f4h3cck 597 15 upORF7 uporf7 CD cord-267475-6f4h3cck 597 16 overlaps overlap VBZ cord-267475-6f4h3cck 597 17 the the DT cord-267475-6f4h3cck 597 18 TPO TPO NNP cord-267475-6f4h3cck 597 19 start start NN cord-267475-6f4h3cck 597 20 site site NN cord-267475-6f4h3cck 597 21 . . . cord-267475-6f4h3cck 598 1 Various various JJ cord-267475-6f4h3cck 598 2 mutations mutation NNS cord-267475-6f4h3cck 598 3 ( ( -LRB- cord-267475-6f4h3cck 598 4 shown show VBN cord-267475-6f4h3cck 598 5 in in IN cord-267475-6f4h3cck 598 6 red red JJ cord-267475-6f4h3cck 598 7 ) ) -RRB- cord-267475-6f4h3cck 598 8 that that WDT cord-267475-6f4h3cck 598 9 relieve relieve VBP cord-267475-6f4h3cck 598 10 this this DT cord-267475-6f4h3cck 598 11 constraint constraint NN cord-267475-6f4h3cck 598 12 elevate elevate VBP cord-267475-6f4h3cck 598 13 the the DT cord-267475-6f4h3cck 598 14 translation translation NN cord-267475-6f4h3cck 598 15 of of IN cord-267475-6f4h3cck 598 16 TPO TPO NNP cord-267475-6f4h3cck 598 17 , , , cord-267475-6f4h3cck 598 18 and and CC cord-267475-6f4h3cck 598 19 this this DT cord-267475-6f4h3cck 598 20 overproduction overproduction NN cord-267475-6f4h3cck 598 21 causes cause VBZ cord-267475-6f4h3cck 598 22 hereditary hereditary JJ cord-267475-6f4h3cck 598 23 thrombocythemia thrombocythemia NN cord-267475-6f4h3cck 598 24 . . . cord-267475-6f4h3cck 599 1 Among among IN cord-267475-6f4h3cck 599 2 the the DT cord-267475-6f4h3cck 599 3 normal normal JJ cord-267475-6f4h3cck 599 4 set set NN cord-267475-6f4h3cck 599 5 of of IN cord-267475-6f4h3cck 599 6 mRNAs mrnas CD cord-267475-6f4h3cck 599 7 , , , cord-267475-6f4h3cck 599 8 the the DT cord-267475-6f4h3cck 599 9 ' ' `` cord-267475-6f4h3cck 599 10 rare rare JJ cord-267475-6f4h3cck 599 11 ' ' '' cord-267475-6f4h3cck 599 12 transcript transcript NN cord-267475-6f4h3cck 599 13 from from IN cord-267475-6f4h3cck 599 14 promoter promoter NN cord-267475-6f4h3cck 599 15 P1 P1 NNP cord-267475-6f4h3cck 599 16 ( ( -LRB- cord-267475-6f4h3cck 599 17 line line NN cord-267475-6f4h3cck 599 18 2 2 CD cord-267475-6f4h3cck 599 19 ) ) -RRB- cord-267475-6f4h3cck 599 20 supports support VBZ cord-267475-6f4h3cck 599 21 translation translation NN cord-267475-6f4h3cck 599 22 slightly slightly RB cord-267475-6f4h3cck 599 23 better well JJR cord-267475-6f4h3cck 599 24 than than IN cord-267475-6f4h3cck 599 25 the the DT cord-267475-6f4h3cck 599 26 others other NNS cord-267475-6f4h3cck 599 27 , , , cord-267475-6f4h3cck 599 28 perhaps perhaps RB cord-267475-6f4h3cck 599 29 because because IN cord-267475-6f4h3cck 599 30 the the DT cord-267475-6f4h3cck 599 31 short short JJ cord-267475-6f4h3cck 599 32 distance distance NN cord-267475-6f4h3cck 599 33 between between IN cord-267475-6f4h3cck 599 34 upORF2 uporf2 CD cord-267475-6f4h3cck 599 35 and and CC cord-267475-6f4h3cck 599 36 AUG#7 AUG#7 NNS cord-267475-6f4h3cck 599 37 enables enable VBZ cord-267475-6f4h3cck 599 38 some some DT cord-267475-6f4h3cck 599 39 reinitiating reinitiating NN cord-267475-6f4h3cck 599 40 ribosomes ribosome NNS cord-267475-6f4h3cck 599 41 to to TO cord-267475-6f4h3cck 599 42 bypass bypass VB cord-267475-6f4h3cck 599 43 AUG#7 AUG#7 NNPS cord-267475-6f4h3cck 599 44 and and CC cord-267475-6f4h3cck 599 45 thus thus RB cord-267475-6f4h3cck 599 46 reach reach VB cord-267475-6f4h3cck 599 47 AUG#8 AUG#8 NNPS cord-267475-6f4h3cck 599 48 . . . cord-267475-6f4h3cck 600 1 Because because IN cord-267475-6f4h3cck 600 2 of of IN cord-267475-6f4h3cck 600 3 the the DT cord-267475-6f4h3cck 600 4 strong strong JJ cord-267475-6f4h3cck 600 5 context context NN cord-267475-6f4h3cck 600 6 at at IN cord-267475-6f4h3cck 600 7 AUGs aug NNS cord-267475-6f4h3cck 600 8 # # $ cord-267475-6f4h3cck 600 9 1 1 CD cord-267475-6f4h3cck 600 10 and and CC cord-267475-6f4h3cck 600 11 # # $ cord-267475-6f4h3cck 600 12 2 2 CD cord-267475-6f4h3cck 600 13 , , , cord-267475-6f4h3cck 600 14 upORFs uporfs JJ cord-267475-6f4h3cck 600 15 1 1 CD cord-267475-6f4h3cck 600 16 and and CC cord-267475-6f4h3cck 600 17 2 2 CD cord-267475-6f4h3cck 600 18 would would MD cord-267475-6f4h3cck 600 19 be be VB cord-267475-6f4h3cck 600 20 more more RBR cord-267475-6f4h3cck 600 21 effective effective JJ cord-267475-6f4h3cck 600 22 than than IN cord-267475-6f4h3cck 600 23 upORFs upORFs NNP cord-267475-6f4h3cck 600 24 5 5 CD cord-267475-6f4h3cck 600 25 and and CC cord-267475-6f4h3cck 600 26 6 6 CD cord-267475-6f4h3cck 600 27 in in IN cord-267475-6f4h3cck 600 28 setting set VBG cord-267475-6f4h3cck 600 29 up up RP cord-267475-6f4h3cck 600 30 this this DT cord-267475-6f4h3cck 600 31 reinitiation reinitiation NN cord-267475-6f4h3cck 600 32 shunt shunt NN cord-267475-6f4h3cck 600 33 . . . cord-267475-6f4h3cck 601 1 The the DT cord-267475-6f4h3cck 601 2 depicted depicted JJ cord-267475-6f4h3cck 601 3 scheme scheme NN cord-267475-6f4h3cck 601 4 is be VBZ cord-267475-6f4h3cck 601 5 based base VBN cord-267475-6f4h3cck 601 6 on on IN cord-267475-6f4h3cck 601 7 experiments experiment NNS cord-267475-6f4h3cck 601 8 described describe VBN cord-267475-6f4h3cck 601 9 by by IN cord-267475-6f4h3cck 601 10 Ghilardi Ghilardi NNP cord-267475-6f4h3cck 601 11 et et NNP cord-267475-6f4h3cck 601 12 al al NNP cord-267475-6f4h3cck 601 13 . . . cord-267475-6f4h3cck 602 1 ( ( -LRB- cord-267475-6f4h3cck 602 2 1998 1998 CD cord-267475-6f4h3cck 602 3 ) ) -RRB- cord-267475-6f4h3cck 602 4 and and CC cord-267475-6f4h3cck 602 5 Wiestner Wiestner NNP cord-267475-6f4h3cck 602 6 et et NNP cord-267475-6f4h3cck 602 7 al al NNP cord-267475-6f4h3cck 602 8 . . . cord-267475-6f4h3cck 603 1 ( ( -LRB- cord-267475-6f4h3cck 603 2 1998 1998 CD cord-267475-6f4h3cck 603 3 ) ) -RRB- cord-267475-6f4h3cck 603 4 . . . cord-267475-6f4h3cck 604 1 Additional additional JJ cord-267475-6f4h3cck 604 2 mutations mutation NNS cord-267475-6f4h3cck 604 3 diagrammed diagram VBN cord-267475-6f4h3cck 604 4 near near IN cord-267475-6f4h3cck 604 5 the the DT cord-267475-6f4h3cck 604 6 bottom bottom NN cord-267475-6f4h3cck 604 7 of of IN cord-267475-6f4h3cck 604 8 the the DT cord-267475-6f4h3cck 604 9 figure figure NN cord-267475-6f4h3cck 604 10 were be VBD cord-267475-6f4h3cck 604 11 described describe VBN cord-267475-6f4h3cck 604 12 by by IN cord-267475-6f4h3cck 604 13 , , , cord-267475-6f4h3cck 604 14 , , , cord-267475-6f4h3cck 604 15 and and CC cord-267475-6f4h3cck 604 16 Kondo Kondo NNP cord-267475-6f4h3cck 604 17 et et NNP cord-267475-6f4h3cck 604 18 al al NNP cord-267475-6f4h3cck 604 19 . . . cord-267475-6f4h3cck 605 1 ( ( -LRB- cord-267475-6f4h3cck 605 2 1998 1998 CD cord-267475-6f4h3cck 605 3 ) ) -RRB- cord-267475-6f4h3cck 605 4 . . . cord-267475-6f4h3cck 606 1 downstream downstream JJ cord-267475-6f4h3cck 606 2 . . . cord-267475-6f4h3cck 607 1 If if IN cord-267475-6f4h3cck 607 2 the the DT cord-267475-6f4h3cck 607 3 upORF upORF NNP cord-267475-6f4h3cck 607 4 itself -PRON- PRP cord-267475-6f4h3cck 607 5 has have VBZ cord-267475-6f4h3cck 607 6 a a DT cord-267475-6f4h3cck 607 7 suboptimal suboptimal JJ cord-267475-6f4h3cck 607 8 initiation initiation NN cord-267475-6f4h3cck 607 9 site site NN cord-267475-6f4h3cck 607 10 ( ( -LRB- cord-267475-6f4h3cck 607 11 U U NNP cord-267475-6f4h3cck 607 12 in in IN cord-267475-6f4h3cck 607 13 position position NN cord-267475-6f4h3cck 607 14 2 2 CD cord-267475-6f4h3cck 607 15 3 3 CD cord-267475-6f4h3cck 607 16 in in IN cord-267475-6f4h3cck 607 17 the the DT cord-267475-6f4h3cck 607 18 depicted depict VBN cord-267475-6f4h3cck 607 19 example example NN cord-267475-6f4h3cck 607 20 ) ) -RRB- cord-267475-6f4h3cck 607 21 , , , cord-267475-6f4h3cck 607 22 leaky leaky JJ cord-267475-6f4h3cck 607 23 scanning scanning NN cord-267475-6f4h3cck 607 24 will will MD cord-267475-6f4h3cck 607 25 allow allow VB cord-267475-6f4h3cck 607 26 some some DT cord-267475-6f4h3cck 607 27 production production NN cord-267475-6f4h3cck 607 28 of of IN cord-267475-6f4h3cck 607 29 the the DT cord-267475-6f4h3cck 607 30 long long JJ cord-267475-6f4h3cck 607 31 protein protein NN cord-267475-6f4h3cck 607 32 isoform isoform NN cord-267475-6f4h3cck 607 33 from from IN cord-267475-6f4h3cck 607 34 the the DT cord-267475-6f4h3cck 607 35 first first JJ cord-267475-6f4h3cck 607 36 in in IN cord-267475-6f4h3cck 607 37 - - HYPH cord-267475-6f4h3cck 607 38 frame frame NN cord-267475-6f4h3cck 607 39 AUG AUG NNP cord-267475-6f4h3cck 607 40 codon codon NN cord-267475-6f4h3cck 607 41 while while IN cord-267475-6f4h3cck 607 42 the the DT cord-267475-6f4h3cck 607 43 reinitiation reinitiation NN cord-267475-6f4h3cck 607 44 shunt shunt NN cord-267475-6f4h3cck 607 45 promotes promote VBZ cord-267475-6f4h3cck 607 46 production production NN cord-267475-6f4h3cck 607 47 of of IN cord-267475-6f4h3cck 607 48 the the DT cord-267475-6f4h3cck 607 49 shorter short JJR cord-267475-6f4h3cck 607 50 protein protein NN cord-267475-6f4h3cck 607 51 isoform isoform NN cord-267475-6f4h3cck 607 52 . . . cord-267475-6f4h3cck 608 1 The the DT cord-267475-6f4h3cck 608 2 operation operation NN cord-267475-6f4h3cck 608 3 of of IN cord-267475-6f4h3cck 608 4 a a DT cord-267475-6f4h3cck 608 5 reinitiation reinitiation NN cord-267475-6f4h3cck 608 6 shunt shunt NN cord-267475-6f4h3cck 608 7 is be VBZ cord-267475-6f4h3cck 608 8 most most RBS cord-267475-6f4h3cck 608 9 obvious obvious JJ cord-267475-6f4h3cck 608 10 when when WRB cord-267475-6f4h3cck 608 11 the the DT cord-267475-6f4h3cck 608 12 upORF uporf JJ cord-267475-6f4h3cck 608 13 overlaps overlap VBZ cord-267475-6f4h3cck 608 14 a a DT cord-267475-6f4h3cck 608 15 potential potential JJ cord-267475-6f4h3cck 608 16 start start NN cord-267475-6f4h3cck 608 17 codon codon NN cord-267475-6f4h3cck 608 18 , , , cord-267475-6f4h3cck 608 19 as as IN cord-267475-6f4h3cck 608 20 shown show VBN cord-267475-6f4h3cck 608 21 in in IN cord-267475-6f4h3cck 608 22 Fig Fig NNP cord-267475-6f4h3cck 608 23 . . . cord-267475-6f4h3cck 608 24 3C 3C NNP cord-267475-6f4h3cck 608 25 , , , cord-267475-6f4h3cck 608 26 but but CC cord-267475-6f4h3cck 608 27 the the DT cord-267475-6f4h3cck 608 28 same same JJ cord-267475-6f4h3cck 608 29 principle principle NN cord-267475-6f4h3cck 608 30 applies apply VBZ cord-267475-6f4h3cck 608 31 in in IN cord-267475-6f4h3cck 608 32 cases case NNS cord-267475-6f4h3cck 608 33 ( ( -LRB- cord-267475-6f4h3cck 608 34 discussed discuss VBN cord-267475-6f4h3cck 608 35 in in IN cord-267475-6f4h3cck 608 36 Section section NN cord-267475-6f4h3cck 608 37 4.3 4.3 CD cord-267475-6f4h3cck 608 38 ) ) -RRB- cord-267475-6f4h3cck 608 39 where where WRB cord-267475-6f4h3cck 608 40 , , , cord-267475-6f4h3cck 608 41 although although IN cord-267475-6f4h3cck 608 42 the the DT cord-267475-6f4h3cck 608 43 upORF uporf JJ cord-267475-6f4h3cck 608 44 terminates terminate VBZ cord-267475-6f4h3cck 608 45 prior prior RB cord-267475-6f4h3cck 608 46 to to IN cord-267475-6f4h3cck 608 47 a a DT cord-267475-6f4h3cck 608 48 potential potential JJ cord-267475-6f4h3cck 608 49 downstream downstream NN cord-267475-6f4h3cck 608 50 start start NN cord-267475-6f4h3cck 608 51 codon codon NN cord-267475-6f4h3cck 608 52 , , , cord-267475-6f4h3cck 608 53 the the DT cord-267475-6f4h3cck 608 54 intervening intervene VBG cord-267475-6f4h3cck 608 55 distance distance NN cord-267475-6f4h3cck 608 56 is be VBZ cord-267475-6f4h3cck 608 57 too too RB cord-267475-6f4h3cck 608 58 short short JJ cord-267475-6f4h3cck 608 59 to to TO cord-267475-6f4h3cck 608 60 allow allow VB cord-267475-6f4h3cck 608 61 reinitiation reinitiation NN cord-267475-6f4h3cck 608 62 . . . cord-267475-6f4h3cck 609 1 The the DT cord-267475-6f4h3cck 609 2 fourth fourth JJ cord-267475-6f4h3cck 609 3 regulatory regulatory JJ cord-267475-6f4h3cck 609 4 mechanism mechanism NN cord-267475-6f4h3cck 609 5 diagrammed diagram VBN cord-267475-6f4h3cck 609 6 in in IN cord-267475-6f4h3cck 609 7 Fig Fig NNP cord-267475-6f4h3cck 609 8 . . . cord-267475-6f4h3cck 610 1 3 3 CD cord-267475-6f4h3cck 610 2 is be VBZ cord-267475-6f4h3cck 610 3 used use VBN cord-267475-6f4h3cck 610 4 only only RB cord-267475-6f4h3cck 610 5 rarely rarely RB cord-267475-6f4h3cck 610 6 . . . cord-267475-6f4h3cck 611 1 Mammalian mammalian JJ cord-267475-6f4h3cck 611 2 AdoMetDC AdoMetDC NNP cord-267475-6f4h3cck 612 1 mRNA mRNA NNP cord-267475-6f4h3cck 612 2 is be VBZ cord-267475-6f4h3cck 612 3 the the DT cord-267475-6f4h3cck 612 4 best well RBS cord-267475-6f4h3cck 612 5 studied study VBN cord-267475-6f4h3cck 612 6 example example NN cord-267475-6f4h3cck 612 7 in in IN cord-267475-6f4h3cck 612 8 which which WDT cord-267475-6f4h3cck 612 9 a a DT cord-267475-6f4h3cck 612 10 small small JJ cord-267475-6f4h3cck 612 11 upORF uporf NN cord-267475-6f4h3cck 612 12 encodes encode VBZ cord-267475-6f4h3cck 612 13 a a DT cord-267475-6f4h3cck 612 14 peptide peptide NN cord-267475-6f4h3cck 612 15 which which WDT cord-267475-6f4h3cck 612 16 functions function NNS cord-267475-6f4h3cck 612 17 in in IN cord-267475-6f4h3cck 612 18 cis cis NNP cord-267475-6f4h3cck 612 19 to to TO cord-267475-6f4h3cck 612 20 inhibit inhibit VB cord-267475-6f4h3cck 612 21 downstream downstream JJ cord-267475-6f4h3cck 612 22 translation translation NN cord-267475-6f4h3cck 612 23 . . . cord-267475-6f4h3cck 613 1 The the DT cord-267475-6f4h3cck 613 2 nascent nascent JJ cord-267475-6f4h3cck 613 3 peptide peptide NN cord-267475-6f4h3cck 613 4 ( ( -LRB- cord-267475-6f4h3cck 613 5 MAGDIS MAGDIS NNP cord-267475-6f4h3cck 613 6 ) ) -RRB- cord-267475-6f4h3cck 613 7 produced produce VBD cord-267475-6f4h3cck 613 8 during during IN cord-267475-6f4h3cck 613 9 translation translation NN cord-267475-6f4h3cck 613 10 of of IN cord-267475-6f4h3cck 613 11 the the DT cord-267475-6f4h3cck 613 12 upORF uporf NN cord-267475-6f4h3cck 613 13 is be VBZ cord-267475-6f4h3cck 613 14 thought think VBN cord-267475-6f4h3cck 613 15 to to TO cord-267475-6f4h3cck 613 16 interact interact VB cord-267475-6f4h3cck 613 17 with with IN cord-267475-6f4h3cck 613 18 ribosomes ribosome NNS cord-267475-6f4h3cck 613 19 in in IN cord-267475-6f4h3cck 613 20 a a DT cord-267475-6f4h3cck 613 21 way way NN cord-267475-6f4h3cck 613 22 that that WDT cord-267475-6f4h3cck 613 23 prevents prevent VBZ cord-267475-6f4h3cck 613 24 completion completion NN cord-267475-6f4h3cck 613 25 of of IN cord-267475-6f4h3cck 613 26 the the DT cord-267475-6f4h3cck 613 27 termination termination NN cord-267475-6f4h3cck 613 28 process process NN cord-267475-6f4h3cck 613 29 and and CC cord-267475-6f4h3cck 613 30 thus thus RB cord-267475-6f4h3cck 613 31 prevents prevent VBZ cord-267475-6f4h3cck 613 32 reinitiation reinitiation NN cord-267475-6f4h3cck 613 33 ( ( -LRB- cord-267475-6f4h3cck 613 34 Law Law NNP cord-267475-6f4h3cck 613 35 et et NNP cord-267475-6f4h3cck 613 36 al al NNP cord-267475-6f4h3cck 613 37 . . NNP cord-267475-6f4h3cck 613 38 , , , cord-267475-6f4h3cck 613 39 2001 2001 CD cord-267475-6f4h3cck 613 40 ) ) -RRB- cord-267475-6f4h3cck 613 41 . . . cord-267475-6f4h3cck 614 1 The the DT cord-267475-6f4h3cck 614 2 stalled stall VBN cord-267475-6f4h3cck 614 3 ribosome ribosome NN cord-267475-6f4h3cck 614 4 , , , cord-267475-6f4h3cck 614 5 held hold VBN cord-267475-6f4h3cck 614 6 at at IN cord-267475-6f4h3cck 614 7 the the DT cord-267475-6f4h3cck 614 8 termination termination NN cord-267475-6f4h3cck 614 9 site site NN cord-267475-6f4h3cck 614 10 of of IN cord-267475-6f4h3cck 614 11 the the DT cord-267475-6f4h3cck 614 12 upORF uporf JJ cord-267475-6f4h3cck 614 13 , , , cord-267475-6f4h3cck 614 14 would would MD cord-267475-6f4h3cck 614 15 also also RB cord-267475-6f4h3cck 614 16 block block VB cord-267475-6f4h3cck 614 17 other other JJ cord-267475-6f4h3cck 614 18 ribosomes ribosome NNS cord-267475-6f4h3cck 614 19 from from IN cord-267475-6f4h3cck 614 20 reaching reach VBG cord-267475-6f4h3cck 614 21 the the DT cord-267475-6f4h3cck 614 22 downstream downstream JJ cord-267475-6f4h3cck 614 23 start start NN cord-267475-6f4h3cck 614 24 site site NN cord-267475-6f4h3cck 614 25 via via IN cord-267475-6f4h3cck 614 26 leaky leaky JJ cord-267475-6f4h3cck 614 27 scanning scanning NN cord-267475-6f4h3cck 614 28 . . . cord-267475-6f4h3cck 615 1 Biologically biologically RB cord-267475-6f4h3cck 615 2 , , , cord-267475-6f4h3cck 615 3 this this DT cord-267475-6f4h3cck 615 4 mechanism mechanism NN cord-267475-6f4h3cck 615 5 is be VBZ cord-267475-6f4h3cck 615 6 important important JJ cord-267475-6f4h3cck 615 7 because because IN cord-267475-6f4h3cck 615 8 Ado Ado NNP cord-267475-6f4h3cck 615 9 - - HYPH cord-267475-6f4h3cck 615 10 MetDC MetDC NNP cord-267475-6f4h3cck 615 11 is be VBZ cord-267475-6f4h3cck 615 12 a a DT cord-267475-6f4h3cck 615 13 key key JJ cord-267475-6f4h3cck 615 14 enzyme enzyme NN cord-267475-6f4h3cck 615 15 in in IN cord-267475-6f4h3cck 615 16 polyamine polyamine NN cord-267475-6f4h3cck 615 17 biosynthesis biosynthesis NN cord-267475-6f4h3cck 615 18 and and CC cord-267475-6f4h3cck 615 19 , , , cord-267475-6f4h3cck 615 20 at at IN cord-267475-6f4h3cck 615 21 least least JJS cord-267475-6f4h3cck 615 22 in in IN cord-267475-6f4h3cck 615 23 vitro vitro FW cord-267475-6f4h3cck 615 24 , , , cord-267475-6f4h3cck 615 25 elevated elevated JJ cord-267475-6f4h3cck 615 26 polyamine polyamine NN cord-267475-6f4h3cck 615 27 levels level NNS cord-267475-6f4h3cck 615 28 stabilize stabilize VBP cord-267475-6f4h3cck 615 29 the the DT cord-267475-6f4h3cck 615 30 ribosome ribosome NN cord-267475-6f4h3cck 615 31 complex complex NN cord-267475-6f4h3cck 615 32 stalled stall VBD cord-267475-6f4h3cck 615 33 at at IN cord-267475-6f4h3cck 615 34 the the DT cord-267475-6f4h3cck 615 35 end end NN cord-267475-6f4h3cck 615 36 of of IN cord-267475-6f4h3cck 615 37 the the DT cord-267475-6f4h3cck 615 38 upORF uporf JJ cord-267475-6f4h3cck 615 39 ( ( -LRB- cord-267475-6f4h3cck 615 40 Law Law NNP cord-267475-6f4h3cck 615 41 et et NNP cord-267475-6f4h3cck 615 42 al al NNP cord-267475-6f4h3cck 615 43 . . NNP cord-267475-6f4h3cck 615 44 , , , cord-267475-6f4h3cck 615 45 2001 2001 CD cord-267475-6f4h3cck 615 46 ) ) -RRB- cord-267475-6f4h3cck 615 47 . . . cord-267475-6f4h3cck 616 1 In in IN cord-267475-6f4h3cck 616 2 other other JJ cord-267475-6f4h3cck 616 3 words word NNS cord-267475-6f4h3cck 616 4 , , , cord-267475-6f4h3cck 616 5 elevated elevated JJ cord-267475-6f4h3cck 616 6 polyamine polyamine NN cord-267475-6f4h3cck 616 7 levels level NNS cord-267475-6f4h3cck 616 8 down down RB cord-267475-6f4h3cck 616 9 - - HYPH cord-267475-6f4h3cck 616 10 regulate regulate VBP cord-267475-6f4h3cck 616 11 translation translation NN cord-267475-6f4h3cck 616 12 of of IN cord-267475-6f4h3cck 616 13 AdoMetDC AdoMetDC NNP cord-267475-6f4h3cck 616 14 . . . cord-267475-6f4h3cck 617 1 It -PRON- PRP cord-267475-6f4h3cck 617 2 is be VBZ cord-267475-6f4h3cck 617 3 interesting interesting JJ cord-267475-6f4h3cck 617 4 to to TO cord-267475-6f4h3cck 617 5 note note VB cord-267475-6f4h3cck 617 6 parenthetically parenthetically RB cord-267475-6f4h3cck 617 7 that that IN cord-267475-6f4h3cck 617 8 antizyme antizyme NNS cord-267475-6f4h3cck 617 9 , , , cord-267475-6f4h3cck 617 10 a a DT cord-267475-6f4h3cck 617 11 protein protein NN cord-267475-6f4h3cck 617 12 that that WDT cord-267475-6f4h3cck 617 13 downregulates downregulate VBZ cord-267475-6f4h3cck 617 14 polyamine polyamine NN cord-267475-6f4h3cck 617 15 levels level NNS cord-267475-6f4h3cck 617 16 , , , cord-267475-6f4h3cck 617 17 is be VBZ cord-267475-6f4h3cck 617 18 also also RB cord-267475-6f4h3cck 617 19 translated translate VBN cord-267475-6f4h3cck 617 20 via via IN cord-267475-6f4h3cck 617 21 a a DT cord-267475-6f4h3cck 617 22 polyamine polyamine NN cord-267475-6f4h3cck 617 23 - - HYPH cord-267475-6f4h3cck 617 24 sensitive sensitive JJ cord-267475-6f4h3cck 617 25 mechanism mechanism NN cord-267475-6f4h3cck 617 26 . . . cord-267475-6f4h3cck 618 1 Elevated elevated JJ cord-267475-6f4h3cck 618 2 polyamine polyamine NN cord-267475-6f4h3cck 618 3 levels level NNS cord-267475-6f4h3cck 618 4 up up RB cord-267475-6f4h3cck 618 5 - - HYPH cord-267475-6f4h3cck 618 6 regulate regulate VB cord-267475-6f4h3cck 618 7 production production NN cord-267475-6f4h3cck 618 8 of of IN cord-267475-6f4h3cck 618 9 antizyme antizyme NNS cord-267475-6f4h3cck 618 10 by by IN cord-267475-6f4h3cck 618 11 promoting promote VBG cord-267475-6f4h3cck 618 12 a a DT cord-267475-6f4h3cck 618 13 ribosomal ribosomal JJ cord-267475-6f4h3cck 618 14 frameshift frameshift NN cord-267475-6f4h3cck 618 15 needed need VBN cord-267475-6f4h3cck 618 16 to to TO cord-267475-6f4h3cck 618 17 translate translate VB cord-267475-6f4h3cck 618 18 the the DT cord-267475-6f4h3cck 618 19 full full JJ cord-267475-6f4h3cck 618 20 - - HYPH cord-267475-6f4h3cck 618 21 length length NN cord-267475-6f4h3cck 618 22 protein protein NN cord-267475-6f4h3cck 618 23 ( ( -LRB- cord-267475-6f4h3cck 618 24 Ivanov Ivanov NNP cord-267475-6f4h3cck 618 25 et et NNP cord-267475-6f4h3cck 618 26 al al NNP cord-267475-6f4h3cck 618 27 . . NNP cord-267475-6f4h3cck 618 28 , , , cord-267475-6f4h3cck 618 29 2000 2000 CD cord-267475-6f4h3cck 618 30 ) ) -RRB- cord-267475-6f4h3cck 618 31 . . . cord-267475-6f4h3cck 619 1 The the DT cord-267475-6f4h3cck 619 2 foregoing forego VBG cord-267475-6f4h3cck 619 3 examples example NNS cord-267475-6f4h3cck 619 4 illustrate illustrate VBP cord-267475-6f4h3cck 619 5 how how WRB cord-267475-6f4h3cck 619 6 reinitiation reinitiation NN cord-267475-6f4h3cck 619 7 operates operate VBZ cord-267475-6f4h3cck 619 8 as as IN cord-267475-6f4h3cck 619 9 part part NN cord-267475-6f4h3cck 619 10 of of IN cord-267475-6f4h3cck 619 11 the the DT cord-267475-6f4h3cck 619 12 normal normal JJ cord-267475-6f4h3cck 619 13 translation translation NN cord-267475-6f4h3cck 619 14 mechanism mechanism NN cord-267475-6f4h3cck 619 15 in in IN cord-267475-6f4h3cck 619 16 cases case NNS cord-267475-6f4h3cck 619 17 where where WRB cord-267475-6f4h3cck 619 18 upORFs upORFs NNP cord-267475-6f4h3cck 619 19 are be VBP cord-267475-6f4h3cck 619 20 constitutively constitutively RB cord-267475-6f4h3cck 619 21 present present JJ cord-267475-6f4h3cck 619 22 in in IN cord-267475-6f4h3cck 619 23 mRNAs mrnas PRP cord-267475-6f4h3cck 619 24 . . . cord-267475-6f4h3cck 620 1 There there EX cord-267475-6f4h3cck 620 2 are be VBP cord-267475-6f4h3cck 620 3 other other JJ cord-267475-6f4h3cck 620 4 cases case NNS cord-267475-6f4h3cck 620 5 in in IN cord-267475-6f4h3cck 620 6 which which WDT cord-267475-6f4h3cck 620 7 a a DT cord-267475-6f4h3cck 620 8 reinitiation reinitiation NN cord-267475-6f4h3cck 620 9 mechanism mechanism NN cord-267475-6f4h3cck 620 10 kicks kick VBZ cord-267475-6f4h3cck 620 11 in in RP cord-267475-6f4h3cck 620 12 only only RB cord-267475-6f4h3cck 620 13 when when WRB cord-267475-6f4h3cck 620 14 a a DT cord-267475-6f4h3cck 620 15 nonsense nonsense NN cord-267475-6f4h3cck 620 16 mutation mutation NN cord-267475-6f4h3cck 620 17 is be VBZ cord-267475-6f4h3cck 620 18 introduced introduce VBN cord-267475-6f4h3cck 620 19 in in IN cord-267475-6f4h3cck 620 20 a a DT cord-267475-6f4h3cck 620 21 way way NN cord-267475-6f4h3cck 620 22 that that WDT cord-267475-6f4h3cck 620 23 truncates truncate VBZ cord-267475-6f4h3cck 620 24 the the DT cord-267475-6f4h3cck 620 25 coding code VBG cord-267475-6f4h3cck 620 26 domain domain NN cord-267475-6f4h3cck 620 27 . . . cord-267475-6f4h3cck 621 1 In in IN cord-267475-6f4h3cck 621 2 effect effect NN cord-267475-6f4h3cck 621 3 , , , cord-267475-6f4h3cck 621 4 the the DT cord-267475-6f4h3cck 621 5 normal normal JJ cord-267475-6f4h3cck 621 6 AUG AUG NNP cord-267475-6f4h3cck 621 7 initiator initiator NN cord-267475-6f4h3cck 621 8 codon codon NN cord-267475-6f4h3cck 621 9 becomes become VBZ cord-267475-6f4h3cck 621 10 the the DT cord-267475-6f4h3cck 621 11 start start NN cord-267475-6f4h3cck 621 12 of of IN cord-267475-6f4h3cck 621 13 an an DT cord-267475-6f4h3cck 621 14 upORF uporf JJ cord-267475-6f4h3cck 621 15 , , , cord-267475-6f4h3cck 621 16 following follow VBG cord-267475-6f4h3cck 621 17 which which WDT cord-267475-6f4h3cck 621 18 reinitiation reinitiation NN cord-267475-6f4h3cck 621 19 occurs occur VBZ cord-267475-6f4h3cck 621 20 at at IN cord-267475-6f4h3cck 621 21 a a DT cord-267475-6f4h3cck 621 22 normally normally RB cord-267475-6f4h3cck 621 23 silent silent JJ cord-267475-6f4h3cck 621 24 internal internal JJ cord-267475-6f4h3cck 621 25 AUG AUG NNP cord-267475-6f4h3cck 621 26 codon codon NN cord-267475-6f4h3cck 621 27 ( ( -LRB- cord-267475-6f4h3cck 621 28 Chang Chang NNP cord-267475-6f4h3cck 621 29 and and CC cord-267475-6f4h3cck 621 30 Gould Gould NNP cord-267475-6f4h3cck 621 31 , , , cord-267475-6f4h3cck 621 32 1998 1998 CD cord-267475-6f4h3cck 621 33 ; ; : cord-267475-6f4h3cck 621 34 Ledley Ledley NNP cord-267475-6f4h3cck 621 35 et et NNP cord-267475-6f4h3cck 621 36 al al NNP cord-267475-6f4h3cck 621 37 . . NNP cord-267475-6f4h3cck 621 38 , , , cord-267475-6f4h3cck 621 39 1990 1990 CD cord-267475-6f4h3cck 621 40 ; ; : cord-267475-6f4h3cck 622 1 Zoppi Zoppi NNP cord-267475-6f4h3cck 622 2 et et NNP cord-267475-6f4h3cck 622 3 al al NNP cord-267475-6f4h3cck 622 4 . . NNP cord-267475-6f4h3cck 622 5 , , , cord-267475-6f4h3cck 622 6 1993 1993 CD cord-267475-6f4h3cck 622 7 ) ) -RRB- cord-267475-6f4h3cck 622 8 . . . cord-267475-6f4h3cck 623 1 The the DT cord-267475-6f4h3cck 623 2 N N NNP cord-267475-6f4h3cck 623 3 - - HYPH cord-267475-6f4h3cck 623 4 terminally terminally RB cord-267475-6f4h3cck 623 5 truncated truncate VBN cord-267475-6f4h3cck 623 6 protein protein NN cord-267475-6f4h3cck 623 7 thus thus RB cord-267475-6f4h3cck 623 8 produced produce VBN cord-267475-6f4h3cck 623 9 sometimes sometimes RB cord-267475-6f4h3cck 623 10 retains retain VBZ cord-267475-6f4h3cck 623 11 enough enough JJ cord-267475-6f4h3cck 623 12 function function NN cord-267475-6f4h3cck 623 13 to to TO cord-267475-6f4h3cck 623 14 mitigate mitigate VB cord-267475-6f4h3cck 623 15 the the DT cord-267475-6f4h3cck 623 16 pathological pathological JJ cord-267475-6f4h3cck 623 17 effects effect NNS cord-267475-6f4h3cck 623 18 of of IN cord-267475-6f4h3cck 623 19 the the DT cord-267475-6f4h3cck 623 20 nonsense nonsense NN cord-267475-6f4h3cck 623 21 mutation mutation NN cord-267475-6f4h3cck 623 22 ( ( -LRB- cord-267475-6f4h3cck 623 23 Chang Chang NNP cord-267475-6f4h3cck 623 24 and and CC cord-267475-6f4h3cck 623 25 Gould Gould NNP cord-267475-6f4h3cck 623 26 , , , cord-267475-6f4h3cck 623 27 1998 1998 CD cord-267475-6f4h3cck 623 28 ) ) -RRB- cord-267475-6f4h3cck 623 29 . . . cord-267475-6f4h3cck 624 1 This this DT cord-267475-6f4h3cck 624 2 potential potential JJ cord-267475-6f4h3cck 624 3 rescue rescue NN cord-267475-6f4h3cck 624 4 device device NN cord-267475-6f4h3cck 624 5 often often RB cord-267475-6f4h3cck 624 6 fails fail VBZ cord-267475-6f4h3cck 624 7 , , , cord-267475-6f4h3cck 624 8 however however RB cord-267475-6f4h3cck 624 9 , , , cord-267475-6f4h3cck 624 10 because because IN cord-267475-6f4h3cck 624 11 many many JJ cord-267475-6f4h3cck 624 12 mRNAs mRNAs NNPS cord-267475-6f4h3cck 624 13 are be VBP cord-267475-6f4h3cck 624 14 rapidly rapidly RB cord-267475-6f4h3cck 624 15 degraded degrade VBN cord-267475-6f4h3cck 624 16 when when WRB cord-267475-6f4h3cck 624 17 a a DT cord-267475-6f4h3cck 624 18 nonsense nonsense NN cord-267475-6f4h3cck 624 19 codon codon NN cord-267475-6f4h3cck 624 20 is be VBZ cord-267475-6f4h3cck 624 21 introduced introduce VBN cord-267475-6f4h3cck 624 22 ( ( -LRB- cord-267475-6f4h3cck 624 23 Frischmeyer Frischmeyer NNP cord-267475-6f4h3cck 624 24 and and CC cord-267475-6f4h3cck 624 25 Dietz Dietz NNP cord-267475-6f4h3cck 624 26 , , , cord-267475-6f4h3cck 624 27 1999 1999 CD cord-267475-6f4h3cck 624 28 ; ; : cord-267475-6f4h3cck 625 1 He -PRON- PRP cord-267475-6f4h3cck 625 2 and and CC cord-267475-6f4h3cck 625 3 Jacobson Jacobson NNP cord-267475-6f4h3cck 625 4 , , , cord-267475-6f4h3cck 625 5 2001 2001 CD cord-267475-6f4h3cck 625 6 ) ) -RRB- cord-267475-6f4h3cck 625 7 . . . cord-267475-6f4h3cck 626 1 The the DT cord-267475-6f4h3cck 626 2 mRNA mRNA NNP cord-267475-6f4h3cck 626 3 decay decay NN cord-267475-6f4h3cck 626 4 pathway pathway NN cord-267475-6f4h3cck 626 5 that that WDT cord-267475-6f4h3cck 626 6 targets target VBZ cord-267475-6f4h3cck 626 7 these these DT cord-267475-6f4h3cck 626 8 abnormal abnormal JJ cord-267475-6f4h3cck 626 9 mRNAs mRNAs NNPS cord-267475-6f4h3cck 626 10 is be VBZ cord-267475-6f4h3cck 626 11 activated activate VBN cord-267475-6f4h3cck 626 12 in in IN cord-267475-6f4h3cck 626 13 part part NN cord-267475-6f4h3cck 626 14 by by IN cord-267475-6f4h3cck 626 15 cis cis NNP cord-267475-6f4h3cck 626 16 elements element NNS cord-267475-6f4h3cck 626 17 located locate VBN cord-267475-6f4h3cck 626 18 in in IN cord-267475-6f4h3cck 626 19 the the DT cord-267475-6f4h3cck 626 20 coding code VBG cord-267475-6f4h3cck 626 21 domain domain NN cord-267475-6f4h3cck 626 22 ( ( -LRB- cord-267475-6f4h3cck 626 23 Gudikote Gudikote NNP cord-267475-6f4h3cck 626 24 and and CC cord-267475-6f4h3cck 626 25 Wilkinson Wilkinson NNP cord-267475-6f4h3cck 626 26 , , , cord-267475-6f4h3cck 626 27 2002 2002 CD cord-267475-6f4h3cck 626 28 ) ) -RRB- cord-267475-6f4h3cck 626 29 , , , cord-267475-6f4h3cck 626 30 which which WDT cord-267475-6f4h3cck 626 31 might may MD cord-267475-6f4h3cck 626 32 explain explain VB cord-267475-6f4h3cck 626 33 why why WRB cord-267475-6f4h3cck 626 34 normal normal JJ cord-267475-6f4h3cck 626 35 upORF uporf RB cord-267475-6f4h3cck 626 36 - - HYPH cord-267475-6f4h3cck 626 37 containing contain VBG cord-267475-6f4h3cck 626 38 mRNAs mRNAs . cord-267475-6f4h3cck 627 1 ( ( -LRB- cord-267475-6f4h3cck 627 2 e.g. e.g. IN cord-267475-6f4h3cck 627 3 those those DT cord-267475-6f4h3cck 627 4 discussed discuss VBN cord-267475-6f4h3cck 627 5 in in IN cord-267475-6f4h3cck 627 6 Figs Figs NNP cord-267475-6f4h3cck 627 7 . . . cord-267475-6f4h3cck 628 1 3 3 CD cord-267475-6f4h3cck 628 2 _SP cord-267475-6f4h3cck 628 3 and and CC cord-267475-6f4h3cck 628 4 4 4 LS cord-267475-6f4h3cck 628 5 ) ) -RRB- cord-267475-6f4h3cck 628 6 are be VBP cord-267475-6f4h3cck 628 7 not not RB cord-267475-6f4h3cck 628 8 rapidly rapidly RB cord-267475-6f4h3cck 628 9 degraded degrade VBN cord-267475-6f4h3cck 628 10 . . . cord-267475-6f4h3cck 629 1 Initiation initiation NN cord-267475-6f4h3cck 629 2 factor factor NN cord-267475-6f4h3cck 629 3 eIF2 eIF2 NNP cord-267475-6f4h3cck 629 4 plays play VBZ cord-267475-6f4h3cck 629 5 a a DT cord-267475-6f4h3cck 629 6 key key JJ cord-267475-6f4h3cck 629 7 role role NN cord-267475-6f4h3cck 629 8 in in IN cord-267475-6f4h3cck 629 9 translational translational JJ cord-267475-6f4h3cck 629 10 control control NN cord-267475-6f4h3cck 629 11 ( ( -LRB- cord-267475-6f4h3cck 629 12 Clemens Clemens NNP cord-267475-6f4h3cck 629 13 , , , cord-267475-6f4h3cck 629 14 2001 2001 CD cord-267475-6f4h3cck 629 15 ; ; : cord-267475-6f4h3cck 629 16 Dever Dever NNP cord-267475-6f4h3cck 629 17 , , , cord-267475-6f4h3cck 629 18 2002 2002 CD cord-267475-6f4h3cck 629 19 ) ) -RRB- cord-267475-6f4h3cck 629 20 and and CC cord-267475-6f4h3cck 629 21 mutations mutation NNS cord-267475-6f4h3cck 629 22 that that WDT cord-267475-6f4h3cck 629 23 perturb perturb VBP cord-267475-6f4h3cck 629 24 regulation regulation NN cord-267475-6f4h3cck 629 25 of of IN cord-267475-6f4h3cck 629 26 eIF2 eIF2 NNP cord-267475-6f4h3cck 629 27 have have VBP cord-267475-6f4h3cck 629 28 profound profound JJ cord-267475-6f4h3cck 629 29 pathological pathological JJ cord-267475-6f4h3cck 629 30 consequences consequence NNS cord-267475-6f4h3cck 629 31 ( ( -LRB- cord-267475-6f4h3cck 630 1 Delépine Delépine NNP cord-267475-6f4h3cck 630 2 et et FW cord-267475-6f4h3cck 630 3 al al NNP cord-267475-6f4h3cck 630 4 . . NNP cord-267475-6f4h3cck 630 5 , , , cord-267475-6f4h3cck 630 6 2000 2000 CD cord-267475-6f4h3cck 630 7 ; ; : cord-267475-6f4h3cck 631 1 Han Han NNP cord-267475-6f4h3cck 631 2 et et NNP cord-267475-6f4h3cck 631 3 al al NNP cord-267475-6f4h3cck 631 4 . . NNP cord-267475-6f4h3cck 631 5 , , , cord-267475-6f4h3cck 631 6 2001 2001 CD cord-267475-6f4h3cck 631 7 ; ; : cord-267475-6f4h3cck 631 8 Harding Harding NNP cord-267475-6f4h3cck 631 9 et et NNP cord-267475-6f4h3cck 631 10 al al NNP cord-267475-6f4h3cck 631 11 . . NNP cord-267475-6f4h3cck 631 12 , , , cord-267475-6f4h3cck 631 13 2001 2001 CD cord-267475-6f4h3cck 631 14 ; ; : cord-267475-6f4h3cck 631 15 Van Van NNP cord-267475-6f4h3cck 631 16 der der NNP cord-267475-6f4h3cck 631 17 Knaap Knaap NNP cord-267475-6f4h3cck 631 18 et et NNP cord-267475-6f4h3cck 631 19 al al NNP cord-267475-6f4h3cck 631 20 . . NNP cord-267475-6f4h3cck 631 21 , , , cord-267475-6f4h3cck 631 22 2002 2002 CD cord-267475-6f4h3cck 631 23 ) ) -RRB- cord-267475-6f4h3cck 631 24 . . . cord-267475-6f4h3cck 632 1 Human human JJ cord-267475-6f4h3cck 632 2 genetic genetic JJ cord-267475-6f4h3cck 632 3 disorders disorder NNS cord-267475-6f4h3cck 632 4 have have VBP cord-267475-6f4h3cck 632 5 been be VBN cord-267475-6f4h3cck 632 6 traced trace VBN cord-267475-6f4h3cck 632 7 also also RB cord-267475-6f4h3cck 632 8 to to IN cord-267475-6f4h3cck 632 9 disruption disruption NN cord-267475-6f4h3cck 632 10 of of IN cord-267475-6f4h3cck 632 11 regulatory regulatory JJ cord-267475-6f4h3cck 632 12 mechanisms mechanism NNS cord-267475-6f4h3cck 632 13 mediated mediate VBN cord-267475-6f4h3cck 632 14 by by IN cord-267475-6f4h3cck 632 15 mRNA mrna NN cord-267475-6f4h3cck 632 16 binding bind VBG cord-267475-6f4h3cck 632 17 proteins protein NNS cord-267475-6f4h3cck 632 18 Cazzola Cazzola NNP cord-267475-6f4h3cck 632 19 and and CC cord-267475-6f4h3cck 632 20 Skoda Skoda NNP cord-267475-6f4h3cck 632 21 , , , cord-267475-6f4h3cck 632 22 2000 2000 CD cord-267475-6f4h3cck 632 23 ; ; : cord-267475-6f4h3cck 632 24 Cazzola Cazzola NNP cord-267475-6f4h3cck 632 25 et et NNP cord-267475-6f4h3cck 632 26 al al NNP cord-267475-6f4h3cck 632 27 . . . cord-267475-6f4h3cck 633 1 , , , cord-267475-6f4h3cck 633 2 2002 2002 CD cord-267475-6f4h3cck 633 3 ; ; : cord-267475-6f4h3cck 633 4 Kaytor Kaytor NNP cord-267475-6f4h3cck 633 5 and and CC cord-267475-6f4h3cck 633 6 Orr Orr NNP cord-267475-6f4h3cck 633 7 , , , cord-267475-6f4h3cck 633 8 2001 2001 CD cord-267475-6f4h3cck 633 9 ; ; : cord-267475-6f4h3cck 633 10 Mikulits Mikulits NNP cord-267475-6f4h3cck 633 11 et et NNP cord-267475-6f4h3cck 633 12 al al NNP cord-267475-6f4h3cck 633 13 . . NNP cord-267475-6f4h3cck 633 14 , , , cord-267475-6f4h3cck 633 15 1999 1999 CD cord-267475-6f4h3cck 633 16 ) ) -RRB- cord-267475-6f4h3cck 633 17 . . . cord-267475-6f4h3cck 634 1 Here here RB cord-267475-6f4h3cck 634 2 , , , cord-267475-6f4h3cck 634 3 however however RB cord-267475-6f4h3cck 634 4 , , , cord-267475-6f4h3cck 634 5 I -PRON- PRP cord-267475-6f4h3cck 634 6 focus focus VBP cord-267475-6f4h3cck 634 7 on on IN cord-267475-6f4h3cck 634 8 pathologies pathology NNS cord-267475-6f4h3cck 634 9 resulting result VBG cord-267475-6f4h3cck 634 10 from from IN cord-267475-6f4h3cck 634 11 increases increase NNS cord-267475-6f4h3cck 634 12 or or CC cord-267475-6f4h3cck 634 13 decreases decrease NNS cord-267475-6f4h3cck 634 14 in in IN cord-267475-6f4h3cck 634 15 translation translation NN cord-267475-6f4h3cck 634 16 caused cause VBN cord-267475-6f4h3cck 634 17 directly directly RB cord-267475-6f4h3cck 634 18 by by IN cord-267475-6f4h3cck 634 19 changes change NNS cord-267475-6f4h3cck 634 20 in in IN cord-267475-6f4h3cck 634 21 mRNA mRNA NNP cord-267475-6f4h3cck 634 22 structure structure NN cord-267475-6f4h3cck 634 23 . . . cord-267475-6f4h3cck 635 1 The the DT cord-267475-6f4h3cck 635 2 preceding precede VBG cord-267475-6f4h3cck 635 3 paragraph paragraph NN cord-267475-6f4h3cck 635 4 mentioned mention VBD cord-267475-6f4h3cck 635 5 some some DT cord-267475-6f4h3cck 635 6 cases case NNS cord-267475-6f4h3cck 635 7 in in IN cord-267475-6f4h3cck 635 8 which which WDT cord-267475-6f4h3cck 635 9 an an DT cord-267475-6f4h3cck 635 10 N n NN cord-267475-6f4h3cck 635 11 - - HYPH cord-267475-6f4h3cck 635 12 terminally terminally RB cord-267475-6f4h3cck 635 13 truncated truncated JJ cord-267475-6f4h3cck 635 14 protein protein NN cord-267475-6f4h3cck 635 15 is be VBZ cord-267475-6f4h3cck 635 16 produced produce VBN cord-267475-6f4h3cck 635 17 , , , cord-267475-6f4h3cck 635 18 apparently apparently RB cord-267475-6f4h3cck 635 19 by by IN cord-267475-6f4h3cck 635 20 reinitiation reinitiation NN cord-267475-6f4h3cck 635 21 , , , cord-267475-6f4h3cck 635 22 when when WRB cord-267475-6f4h3cck 635 23 a a DT cord-267475-6f4h3cck 635 24 mutation mutation NN cord-267475-6f4h3cck 635 25 introduces introduce VBZ cord-267475-6f4h3cck 635 26 a a DT cord-267475-6f4h3cck 635 27 premature premature JJ cord-267475-6f4h3cck 635 28 nonsense nonsense NN cord-267475-6f4h3cck 635 29 codon codon NN cord-267475-6f4h3cck 635 30 . . . cord-267475-6f4h3cck 636 1 The the DT cord-267475-6f4h3cck 636 2 effects effect NNS cord-267475-6f4h3cck 636 3 of of IN cord-267475-6f4h3cck 636 4 some some DT cord-267475-6f4h3cck 636 5 other other JJ cord-267475-6f4h3cck 636 6 types type NNS cord-267475-6f4h3cck 636 7 of of IN cord-267475-6f4h3cck 636 8 mutations mutation NNS cord-267475-6f4h3cck 636 9 can can MD cord-267475-6f4h3cck 636 10 also also RB cord-267475-6f4h3cck 636 11 be be VB cord-267475-6f4h3cck 636 12 understood understand VBN cord-267475-6f4h3cck 636 13 in in IN cord-267475-6f4h3cck 636 14 light light NN cord-267475-6f4h3cck 636 15 of of IN cord-267475-6f4h3cck 636 16 the the DT cord-267475-6f4h3cck 636 17 scanning scanning NN cord-267475-6f4h3cck 636 18 mechanism mechanism NN cord-267475-6f4h3cck 636 19 , , , cord-267475-6f4h3cck 636 20 as as IN cord-267475-6f4h3cck 636 21 outlined outline VBN cord-267475-6f4h3cck 636 22 next next RB cord-267475-6f4h3cck 636 23 and and CC cord-267475-6f4h3cck 636 24 discussed discuss VBN cord-267475-6f4h3cck 636 25 elsewhere elsewhere RB cord-267475-6f4h3cck 636 26 in in IN cord-267475-6f4h3cck 636 27 more more JJR cord-267475-6f4h3cck 636 28 detail detail NN cord-267475-6f4h3cck 636 29 ( ( -LRB- cord-267475-6f4h3cck 636 30 Kozak Kozak NNP cord-267475-6f4h3cck 636 31 , , , cord-267475-6f4h3cck 636 32 2002 2002 CD cord-267475-6f4h3cck 636 33 ) ) -RRB- cord-267475-6f4h3cck 636 34 . . . cord-267475-6f4h3cck 637 1 Recent recent JJ cord-267475-6f4h3cck 637 2 investigations investigation NNS cord-267475-6f4h3cck 637 3 have have VBP cord-267475-6f4h3cck 637 4 identified identify VBN cord-267475-6f4h3cck 637 5 diseases disease NNS cord-267475-6f4h3cck 637 6 that that WDT cord-267475-6f4h3cck 637 7 result result VBP cord-267475-6f4h3cck 637 8 from from IN cord-267475-6f4h3cck 637 9 failure failure NN cord-267475-6f4h3cck 637 10 to to TO cord-267475-6f4h3cck 637 11 produce produce VB cord-267475-6f4h3cck 637 12 one one CD cord-267475-6f4h3cck 637 13 of of IN cord-267475-6f4h3cck 637 14 the the DT cord-267475-6f4h3cck 637 15 two two CD cord-267475-6f4h3cck 637 16 protein protein NN cord-267475-6f4h3cck 637 17 isoforms isoform NNS cord-267475-6f4h3cck 637 18 derived derive VBN cord-267475-6f4h3cck 637 19 from from IN cord-267475-6f4h3cck 637 20 genes gene NNS cord-267475-6f4h3cck 637 21 that that WDT cord-267475-6f4h3cck 637 22 encode encode VBP cord-267475-6f4h3cck 637 23 certain certain JJ cord-267475-6f4h3cck 637 24 transcription transcription NN cord-267475-6f4h3cck 637 25 factors factor NNS cord-267475-6f4h3cck 637 26 ( ( -LRB- cord-267475-6f4h3cck 637 27 Table table NN cord-267475-6f4h3cck 637 28 4 4 CD cord-267475-6f4h3cck 637 29 ) ) -RRB- cord-267475-6f4h3cck 637 30 . . . cord-267475-6f4h3cck 638 1 Because because IN cord-267475-6f4h3cck 638 2 the the DT cord-267475-6f4h3cck 638 3 second second JJ cord-267475-6f4h3cck 638 4 isoform isoform NN cord-267475-6f4h3cck 638 5 often often RB cord-267475-6f4h3cck 638 6 functions function VBZ cord-267475-6f4h3cck 638 7 as as IN cord-267475-6f4h3cck 638 8 a a DT cord-267475-6f4h3cck 638 9 modulator modulator NN cord-267475-6f4h3cck 638 10 , , , cord-267475-6f4h3cck 638 11 the the DT cord-267475-6f4h3cck 638 12 transcriptional transcriptional JJ cord-267475-6f4h3cck 638 13 imbalance imbalance NN cord-267475-6f4h3cck 638 14 caused cause VBN cord-267475-6f4h3cck 638 15 by by IN cord-267475-6f4h3cck 638 16 these these DT cord-267475-6f4h3cck 638 17 changes change NNS cord-267475-6f4h3cck 638 18 in in IN cord-267475-6f4h3cck 638 19 translation translation NN cord-267475-6f4h3cck 638 20 can can MD cord-267475-6f4h3cck 638 21 have have VB cord-267475-6f4h3cck 638 22 serious serious JJ cord-267475-6f4h3cck 638 23 consequences consequence NNS cord-267475-6f4h3cck 638 24 . . . cord-267475-6f4h3cck 639 1 Hereditary hereditary JJ cord-267475-6f4h3cck 639 2 diseases disease NNS cord-267475-6f4h3cck 639 3 have have VBP cord-267475-6f4h3cck 639 4 been be VBN cord-267475-6f4h3cck 639 5 traced trace VBN cord-267475-6f4h3cck 639 6 occasionally occasionally RB cord-267475-6f4h3cck 639 7 to to TO cord-267475-6f4h3cck 639 8 point point VB cord-267475-6f4h3cck 639 9 mutations mutation NNS cord-267475-6f4h3cck 639 10 that that WDT cord-267475-6f4h3cck 639 11 alter alter VBP cord-267475-6f4h3cck 639 12 the the DT cord-267475-6f4h3cck 639 13 context context NN cord-267475-6f4h3cck 639 14 flanking flank VBG cord-267475-6f4h3cck 639 15 the the DT cord-267475-6f4h3cck 639 16 AUG AUG NNP cord-267475-6f4h3cck 639 17 START START NNP cord-267475-6f4h3cck 639 18 codon codon NN cord-267475-6f4h3cck 639 19 . . . cord-267475-6f4h3cck 640 1 The the DT cord-267475-6f4h3cck 640 2 list list NN cord-267475-6f4h3cck 640 3 includes include VBZ cord-267475-6f4h3cck 640 4 a a DT cord-267475-6f4h3cck 640 5 - - HYPH cord-267475-6f4h3cck 640 6 thalassaemia thalassaemia NN cord-267475-6f4h3cck 640 7 caused cause VBN cord-267475-6f4h3cck 640 8 by by IN cord-267475-6f4h3cck 640 9 an an DT cord-267475-6f4h3cck 640 10 A a NN cord-267475-6f4h3cck 640 11 ! ! . cord-267475-6f4h3cck 641 1 C C NNP cord-267475-6f4h3cck 641 2 change change NN cord-267475-6f4h3cck 641 3 in in IN cord-267475-6f4h3cck 641 4 position position NN cord-267475-6f4h3cck 641 5 23 23 CD cord-267475-6f4h3cck 641 6 of of IN cord-267475-6f4h3cck 641 7 the the DT cord-267475-6f4h3cck 641 8 a a DT cord-267475-6f4h3cck 641 9 - - HYPH cord-267475-6f4h3cck 641 10 globin globin NN cord-267475-6f4h3cck 641 11 gene gene NN cord-267475-6f4h3cck 641 12 ( ( -LRB- cord-267475-6f4h3cck 641 13 Morlé Morlé NNP cord-267475-6f4h3cck 641 14 et et FW cord-267475-6f4h3cck 641 15 al al NNP cord-267475-6f4h3cck 641 16 . . NNP cord-267475-6f4h3cck 641 17 , , , cord-267475-6f4h3cck 641 18 1985 1985 CD cord-267475-6f4h3cck 641 19 ) ) -RRB- cord-267475-6f4h3cck 641 20 , , , cord-267475-6f4h3cck 641 21 androgen androgen NN cord-267475-6f4h3cck 641 22 insensitivity insensitivity NN cord-267475-6f4h3cck 641 23 syndrome syndrome NN cord-267475-6f4h3cck 641 24 caused cause VBN cord-267475-6f4h3cck 641 25 by by IN cord-267475-6f4h3cck 641 26 a a DT cord-267475-6f4h3cck 641 27 G g NN cord-267475-6f4h3cck 641 28 ! ! . cord-267475-6f4h3cck 642 1 A a DT cord-267475-6f4h3cck 642 2 mutation mutation NN cord-267475-6f4h3cck 642 3 in in IN cord-267475-6f4h3cck 642 4 position position NN cord-267475-6f4h3cck 642 5 þ4 þ4 NNP cord-267475-6f4h3cck 642 6 of of IN cord-267475-6f4h3cck 642 7 the the DT cord-267475-6f4h3cck 642 8 androgen androgen NN cord-267475-6f4h3cck 642 9 receptor receptor NN cord-267475-6f4h3cck 642 10 gene gene NN cord-267475-6f4h3cck 642 11 ( ( -LRB- cord-267475-6f4h3cck 642 12 Choong Choong NNP cord-267475-6f4h3cck 642 13 et et NNP cord-267475-6f4h3cck 642 14 al al NNP cord-267475-6f4h3cck 642 15 . . NNP cord-267475-6f4h3cck 642 16 , , , cord-267475-6f4h3cck 642 17 1996 1996 CD cord-267475-6f4h3cck 642 18 ) ) -RRB- cord-267475-6f4h3cck 642 19 , , , cord-267475-6f4h3cck 642 20 and and CC cord-267475-6f4h3cck 642 21 ataxia ataxia NN cord-267475-6f4h3cck 642 22 with with IN cord-267475-6f4h3cck 642 23 vitamin vitamin NN cord-267475-6f4h3cck 642 24 E e NN cord-267475-6f4h3cck 642 25 deficiency deficiency NN cord-267475-6f4h3cck 642 26 caused cause VBN cord-267475-6f4h3cck 642 27 by by IN cord-267475-6f4h3cck 642 28 a a DT cord-267475-6f4h3cck 642 29 C c NN cord-267475-6f4h3cck 642 30 ! ! . cord-267475-6f4h3cck 643 1 T T NNP cord-267475-6f4h3cck 643 2 mutation mutation NN cord-267475-6f4h3cck 643 3 in in IN cord-267475-6f4h3cck 643 4 position position NN cord-267475-6f4h3cck 643 5 21 21 CD cord-267475-6f4h3cck 643 6 of of IN cord-267475-6f4h3cck 643 7 the the DT cord-267475-6f4h3cck 643 8 a a DT cord-267475-6f4h3cck 643 9 - - HYPH cord-267475-6f4h3cck 643 10 tocopherol tocopherol NN cord-267475-6f4h3cck 643 11 transfer transfer NN cord-267475-6f4h3cck 643 12 protein protein NN cord-267475-6f4h3cck 643 13 gene gene NN cord-267475-6f4h3cck 643 14 ( ( -LRB- cord-267475-6f4h3cck 643 15 Usuki Usuki NNP cord-267475-6f4h3cck 643 16 and and CC cord-267475-6f4h3cck 643 17 Maruyama Maruyama NNP cord-267475-6f4h3cck 643 18 , , , cord-267475-6f4h3cck 643 19 2000 2000 CD cord-267475-6f4h3cck 643 20 ) ) -RRB- cord-267475-6f4h3cck 643 21 . . . cord-267475-6f4h3cck 644 1 There there EX cord-267475-6f4h3cck 644 2 is be VBZ cord-267475-6f4h3cck 644 3 an an DT cord-267475-6f4h3cck 644 4 interesting interesting JJ cord-267475-6f4h3cck 644 5 report report NN cord-267475-6f4h3cck 644 6 of of IN cord-267475-6f4h3cck 644 7 a a DT cord-267475-6f4h3cck 644 8 somatic somatic JJ cord-267475-6f4h3cck 644 9 point point NN cord-267475-6f4h3cck 644 10 mutation mutation NN cord-267475-6f4h3cck 644 11 ( ( -LRB- cord-267475-6f4h3cck 644 12 G g NN cord-267475-6f4h3cck 644 13 ! ! . cord-267475-6f4h3cck 644 14 C c NN cord-267475-6f4h3cck 644 15 in in IN cord-267475-6f4h3cck 644 16 position position NN cord-267475-6f4h3cck 644 17 23 23 CD cord-267475-6f4h3cck 644 18 ) ) -RRB- cord-267475-6f4h3cck 644 19 in in IN cord-267475-6f4h3cck 644 20 the the DT cord-267475-6f4h3cck 644 21 BRCA1 BRCA1 NNP cord-267475-6f4h3cck 644 22 gene gene NN cord-267475-6f4h3cck 644 23 in in IN cord-267475-6f4h3cck 644 24 a a DT cord-267475-6f4h3cck 644 25 highly highly RB cord-267475-6f4h3cck 644 26 aggressive aggressive JJ cord-267475-6f4h3cck 644 27 case case NN cord-267475-6f4h3cck 644 28 of of IN cord-267475-6f4h3cck 644 29 sporadic sporadic JJ cord-267475-6f4h3cck 644 30 breast breast NN cord-267475-6f4h3cck 644 31 cancer cancer NN cord-267475-6f4h3cck 644 32 ( ( -LRB- cord-267475-6f4h3cck 644 33 Signori Signori NNP cord-267475-6f4h3cck 644 34 et et NNP cord-267475-6f4h3cck 644 35 al al NNP cord-267475-6f4h3cck 644 36 . . NNP cord-267475-6f4h3cck 644 37 , , , cord-267475-6f4h3cck 644 38 2001 2001 CD cord-267475-6f4h3cck 644 39 ) ) -RRB- cord-267475-6f4h3cck 644 40 . . . cord-267475-6f4h3cck 645 1 In in IN cord-267475-6f4h3cck 645 2 mice mouse NNS cord-267475-6f4h3cck 645 3 , , , cord-267475-6f4h3cck 645 4 a a DT cord-267475-6f4h3cck 645 5 screen screen NN cord-267475-6f4h3cck 645 6 for for IN cord-267475-6f4h3cck 645 7 mutations mutation NNS cord-267475-6f4h3cck 645 8 that that WDT cord-267475-6f4h3cck 645 9 cause cause VBP cord-267475-6f4h3cck 645 10 defects defect NNS cord-267475-6f4h3cck 645 11 in in IN cord-267475-6f4h3cck 645 12 eye eye NN cord-267475-6f4h3cck 645 13 development development NN cord-267475-6f4h3cck 645 14 uncovered uncover VBD cord-267475-6f4h3cck 645 15 an an DT cord-267475-6f4h3cck 645 16 A a NN cord-267475-6f4h3cck 645 17 ! ! . cord-267475-6f4h3cck 646 1 T T NNP cord-267475-6f4h3cck 646 2 change change NN cord-267475-6f4h3cck 646 3 in in IN cord-267475-6f4h3cck 646 4 position position NN cord-267475-6f4h3cck 646 5 23 23 CD cord-267475-6f4h3cck 646 6 of of IN cord-267475-6f4h3cck 646 7 the the DT cord-267475-6f4h3cck 646 8 Pax6 Pax6 NNP cord-267475-6f4h3cck 646 9 gene gene NN cord-267475-6f4h3cck 647 1 ( ( -LRB- cord-267475-6f4h3cck 647 2 Favor favor NN cord-267475-6f4h3cck 647 3 et et FW cord-267475-6f4h3cck 647 4 al al NNP cord-267475-6f4h3cck 647 5 . . NNP cord-267475-6f4h3cck 647 6 , , , cord-267475-6f4h3cck 647 7 2001 2001 CD cord-267475-6f4h3cck 647 8 ) ) -RRB- cord-267475-6f4h3cck 647 9 . . . cord-267475-6f4h3cck 648 1 Each each DT cord-267475-6f4h3cck 648 2 of of IN cord-267475-6f4h3cck 648 3 these these DT cord-267475-6f4h3cck 648 4 mutations mutation NNS cord-267475-6f4h3cck 648 5 was be VBD cord-267475-6f4h3cck 648 6 shown show VBN cord-267475-6f4h3cck 648 7 to to TO cord-267475-6f4h3cck 648 8 cause cause VB cord-267475-6f4h3cck 648 9 a a DT cord-267475-6f4h3cck 648 10 decrease decrease NN cord-267475-6f4h3cck 648 11 ( ( -LRB- cord-267475-6f4h3cck 648 12 generally generally RB cord-267475-6f4h3cck 648 13 two two CD cord-267475-6f4h3cck 648 14 - - HYPH cord-267475-6f4h3cck 648 15 to to TO cord-267475-6f4h3cck 648 16 four four CD cord-267475-6f4h3cck 648 17 - - RB cord-267475-6f4h3cck 648 18 fold fold RB cord-267475-6f4h3cck 648 19 ) ) -RRB- cord-267475-6f4h3cck 648 20 in in IN cord-267475-6f4h3cck 648 21 translation translation NN cord-267475-6f4h3cck 648 22 . . . cord-267475-6f4h3cck 649 1 Not not RB cord-267475-6f4h3cck 649 2 every every DT cord-267475-6f4h3cck 649 3 mutation mutation NN cord-267475-6f4h3cck 649 4 or or CC cord-267475-6f4h3cck 649 5 polymorphism polymorphism NN cord-267475-6f4h3cck 649 6 within within IN cord-267475-6f4h3cck 649 7 the the DT cord-267475-6f4h3cck 649 8 consensus consensus NN cord-267475-6f4h3cck 649 9 motif motif NN cord-267475-6f4h3cck 649 10 can can MD cord-267475-6f4h3cck 649 11 be be VB cord-267475-6f4h3cck 649 12 explained explain VBN cord-267475-6f4h3cck 649 13 simply simply RB cord-267475-6f4h3cck 649 14 , , , cord-267475-6f4h3cck 649 15 however however RB cord-267475-6f4h3cck 649 16 . . . cord-267475-6f4h3cck 650 1 Other other JJ cord-267475-6f4h3cck 650 2 considerations consideration NNS cord-267475-6f4h3cck 650 3 , , , cord-267475-6f4h3cck 650 4 such such JJ cord-267475-6f4h3cck 650 5 as as IN cord-267475-6f4h3cck 650 6 codon codon NN cord-267475-6f4h3cck 650 7 usage usage NN cord-267475-6f4h3cck 650 8 , , , cord-267475-6f4h3cck 650 9 might may MD cord-267475-6f4h3cck 650 10 prevent prevent VB cord-267475-6f4h3cck 650 11 an an DT cord-267475-6f4h3cck 650 12 increase increase NN cord-267475-6f4h3cck 650 13 in in IN cord-267475-6f4h3cck 650 14 translation translation NN cord-267475-6f4h3cck 650 15 even even RB cord-267475-6f4h3cck 650 16 when when WRB cord-267475-6f4h3cck 650 17 the the DT cord-267475-6f4h3cck 650 18 context context NN cord-267475-6f4h3cck 650 19 is be VBZ cord-267475-6f4h3cck 650 20 improved improve VBN cord-267475-6f4h3cck 650 21 ( ( -LRB- cord-267475-6f4h3cck 650 22 i.e. i.e. FW cord-267475-6f4h3cck 650 23 translation translation NN cord-267475-6f4h3cck 650 24 might may MD cord-267475-6f4h3cck 650 25 be be VB cord-267475-6f4h3cck 650 26 limited limit VBN cord-267475-6f4h3cck 650 27 at at IN cord-267475-6f4h3cck 650 28 the the DT cord-267475-6f4h3cck 650 29 level level NN cord-267475-6f4h3cck 650 30 of of IN cord-267475-6f4h3cck 650 31 elongation elongation NN cord-267475-6f4h3cck 650 32 rather rather RB cord-267475-6f4h3cck 650 33 than than IN cord-267475-6f4h3cck 650 34 initiation initiation NN cord-267475-6f4h3cck 650 35 ) ) -RRB- cord-267475-6f4h3cck 650 36 , , , cord-267475-6f4h3cck 650 37 and and CC cord-267475-6f4h3cck 650 38 some some DT cord-267475-6f4h3cck 650 39 mutations mutation NNS cord-267475-6f4h3cck 650 40 near near IN cord-267475-6f4h3cck 650 41 the the DT cord-267475-6f4h3cck 650 42 AUG AUG NNP cord-267475-6f4h3cck 650 43 codon codon NN cord-267475-6f4h3cck 650 44 might may MD cord-267475-6f4h3cck 650 45 affect affect VB cord-267475-6f4h3cck 650 46 mRNA mrna NN cord-267475-6f4h3cck 650 47 processing processing NN cord-267475-6f4h3cck 650 48 or or CC cord-267475-6f4h3cck 650 49 stability stability NN cord-267475-6f4h3cck 650 50 rather rather RB cord-267475-6f4h3cck 650 51 than than IN cord-267475-6f4h3cck 650 52 translation translation NN cord-267475-6f4h3cck 650 53 per per FW cord-267475-6f4h3cck 650 54 se se FW cord-267475-6f4h3cck 650 55 . . . cord-267475-6f4h3cck 651 1 A a DT cord-267475-6f4h3cck 651 2 clinically clinically RB cord-267475-6f4h3cck 651 3 relevant relevant JJ cord-267475-6f4h3cck 651 4 polymorphism polymorphism NN cord-267475-6f4h3cck 651 5 in in IN cord-267475-6f4h3cck 651 6 position position NN cord-267475-6f4h3cck 651 7 2 2 CD cord-267475-6f4h3cck 651 8 1 1 CD cord-267475-6f4h3cck 651 9 of of IN cord-267475-6f4h3cck 651 10 annexin annexin NNP cord-267475-6f4h3cck 651 11 V V NNP cord-267475-6f4h3cck 651 12 appears appear VBZ cord-267475-6f4h3cck 651 13 to to TO cord-267475-6f4h3cck 651 14 have have VB cord-267475-6f4h3cck 651 15 an an DT cord-267475-6f4h3cck 651 16 effect effect NN cord-267475-6f4h3cck 651 17 on on IN cord-267475-6f4h3cck 651 18 translation translation NN cord-267475-6f4h3cck 651 19 which which WDT cord-267475-6f4h3cck 651 20 is be VBZ cord-267475-6f4h3cck 651 21 inconsistent inconsistent JJ cord-267475-6f4h3cck 651 22 with with IN cord-267475-6f4h3cck 651 23 the the DT cord-267475-6f4h3cck 651 24 context context NN cord-267475-6f4h3cck 651 25 rules rule NNS cord-267475-6f4h3cck 651 26 ( ( -LRB- cord-267475-6f4h3cck 651 27 González González NNP cord-267475-6f4h3cck 651 28 - - HYPH cord-267475-6f4h3cck 651 29 Conejero Conejero NNP cord-267475-6f4h3cck 651 30 et et NNP cord-267475-6f4h3cck 651 31 al al NNP cord-267475-6f4h3cck 651 32 . . NNP cord-267475-6f4h3cck 651 33 , , , cord-267475-6f4h3cck 651 34 2002 2002 CD cord-267475-6f4h3cck 651 35 ) ) -RRB- cord-267475-6f4h3cck 651 36 , , , cord-267475-6f4h3cck 651 37 but but CC cord-267475-6f4h3cck 651 38 the the DT cord-267475-6f4h3cck 651 39 effect effect NN cord-267475-6f4h3cck 651 40 was be VBD cord-267475-6f4h3cck 651 41 small small JJ cord-267475-6f4h3cck 651 42 and and CC cord-267475-6f4h3cck 651 43 documented document VBN cord-267475-6f4h3cck 651 44 only only RB cord-267475-6f4h3cck 651 45 by by IN cord-267475-6f4h3cck 651 46 assaying assay VBG cord-267475-6f4h3cck 651 47 translation translation NN cord-267475-6f4h3cck 651 48 in in IN cord-267475-6f4h3cck 651 49 vitro vitro FW cord-267475-6f4h3cck 651 50 , , , cord-267475-6f4h3cck 651 51 which which WDT cord-267475-6f4h3cck 651 52 is be VBZ cord-267475-6f4h3cck 651 53 not not RB cord-267475-6f4h3cck 651 54 always always RB cord-267475-6f4h3cck 651 55 reliable reliable JJ cord-267475-6f4h3cck 651 56 ( ( -LRB- cord-267475-6f4h3cck 651 57 Section section NN cord-267475-6f4h3cck 651 58 6.2 6.2 CD cord-267475-6f4h3cck 651 59 ) ) -RRB- cord-267475-6f4h3cck 651 60 . . . cord-267475-6f4h3cck 652 1 A a DT cord-267475-6f4h3cck 652 2 natural natural JJ cord-267475-6f4h3cck 652 3 polymorphism polymorphism NN cord-267475-6f4h3cck 652 4 in in IN cord-267475-6f4h3cck 652 5 position position NN cord-267475-6f4h3cck 652 6 2 2 CD cord-267475-6f4h3cck 652 7 5 5 CD cord-267475-6f4h3cck 652 8 of of IN cord-267475-6f4h3cck 652 9 the the DT cord-267475-6f4h3cck 652 10 glycoprotein glycoprotein NN cord-267475-6f4h3cck 652 11 Iba Iba NNP cord-267475-6f4h3cck 652 12 gene gene NN cord-267475-6f4h3cck 652 13 displayed display VBD cord-267475-6f4h3cck 652 14 a a DT cord-267475-6f4h3cck 652 15 small small JJ cord-267475-6f4h3cck 652 16 effect effect NN cord-267475-6f4h3cck 652 17 on on IN cord-267475-6f4h3cck 652 18 translation translation NN cord-267475-6f4h3cck 652 19 in in IN cord-267475-6f4h3cck 652 20 vitro vitro FW cord-267475-6f4h3cck 653 1 that that DT cord-267475-6f4h3cck 653 2 was be VBD cord-267475-6f4h3cck 653 3 consistent consistent JJ cord-267475-6f4h3cck 653 4 with with IN cord-267475-6f4h3cck 653 5 the the DT cord-267475-6f4h3cck 653 6 rules rule NNS cord-267475-6f4h3cck 654 1 ( ( -LRB- cord-267475-6f4h3cck 654 2 C C NNP cord-267475-6f4h3cck 654 3 worked work VBD cord-267475-6f4h3cck 654 4 better well RBR cord-267475-6f4h3cck 654 5 than than IN cord-267475-6f4h3cck 654 6 T T NNP cord-267475-6f4h3cck 654 7 ; ; . cord-267475-6f4h3cck 655 1 Afshar Afshar NNP cord-267475-6f4h3cck 655 2 - - HYPH cord-267475-6f4h3cck 655 3 Kharghan Kharghan NNP cord-267475-6f4h3cck 655 4 et et NNP cord-267475-6f4h3cck 655 5 al al NNP cord-267475-6f4h3cck 655 6 . . NNP cord-267475-6f4h3cck 655 7 , , , cord-267475-6f4h3cck 655 8 1999 1999 CD cord-267475-6f4h3cck 655 9 ) ) -RRB- cord-267475-6f4h3cck 655 10 but but CC cord-267475-6f4h3cck 655 11 , , , cord-267475-6f4h3cck 655 12 in in IN cord-267475-6f4h3cck 655 13 the the DT cord-267475-6f4h3cck 655 14 same same JJ cord-267475-6f4h3cck 655 15 study study NN cord-267475-6f4h3cck 655 16 , , , cord-267475-6f4h3cck 655 17 mutations mutation NNS cord-267475-6f4h3cck 655 18 that that IN cord-267475-6f4h3cck 655 19 changed change VBD cord-267475-6f4h3cck 655 20 position position NN cord-267475-6f4h3cck 655 21 þ þ NNP cord-267475-6f4h3cck 655 22 4 4 CD cord-267475-6f4h3cck 655 23 from from IN cord-267475-6f4h3cck 655 24 C C NNP cord-267475-6f4h3cck 655 25 to to IN cord-267475-6f4h3cck 655 26 G g NN cord-267475-6f4h3cck 655 27 did do VBD cord-267475-6f4h3cck 655 28 not not RB cord-267475-6f4h3cck 655 29 augment augment VB cord-267475-6f4h3cck 655 30 translation translation NN cord-267475-6f4h3cck 655 31 . . . cord-267475-6f4h3cck 656 1 Testing testing NN cord-267475-6f4h3cck 656 2 mutations mutation NNS cord-267475-6f4h3cck 656 3 in in IN cord-267475-6f4h3cck 656 4 position position NN cord-267475-6f4h3cck 657 1 þ þ LS cord-267475-6f4h3cck 657 2 4 4 CD cord-267475-6f4h3cck 657 3 is be VBZ cord-267475-6f4h3cck 657 4 tricky tricky JJ cord-267475-6f4h3cck 657 5 , , , cord-267475-6f4h3cck 657 6 however however RB cord-267475-6f4h3cck 657 7 , , , cord-267475-6f4h3cck 657 8 because because IN cord-267475-6f4h3cck 657 9 the the DT cord-267475-6f4h3cck 657 10 change change NN cord-267475-6f4h3cck 657 11 in in IN cord-267475-6f4h3cck 657 12 identity identity NN cord-267475-6f4h3cck 657 13 of of IN cord-267475-6f4h3cck 657 14 the the DT cord-267475-6f4h3cck 657 15 penultimate penultimate JJ cord-267475-6f4h3cck 657 16 amino amino NN cord-267475-6f4h3cck 657 17 acid acid NN cord-267475-6f4h3cck 657 18 might may MD cord-267475-6f4h3cck 657 19 affect affect VB cord-267475-6f4h3cck 657 20 protein protein NN cord-267475-6f4h3cck 657 21 stability stability NN cord-267475-6f4h3cck 657 22 in in IN cord-267475-6f4h3cck 657 23 ways way NNS cord-267475-6f4h3cck 657 24 that that WDT cord-267475-6f4h3cck 657 25 obscure obscure VBP cord-267475-6f4h3cck 657 26 the the DT cord-267475-6f4h3cck 657 27 effects effect NNS cord-267475-6f4h3cck 657 28 on on IN cord-267475-6f4h3cck 657 29 translation translation NN cord-267475-6f4h3cck 657 30 . . . cord-267475-6f4h3cck 658 1 The the DT cord-267475-6f4h3cck 658 2 solution solution NN cord-267475-6f4h3cck 658 3 is be VBZ cord-267475-6f4h3cck 658 4 to to TO cord-267475-6f4h3cck 658 5 use use VB cord-267475-6f4h3cck 658 6 an an DT cord-267475-6f4h3cck 658 7 assay assay NN cord-267475-6f4h3cck 658 8 that that WDT cord-267475-6f4h3cck 658 9 directly directly RB cord-267475-6f4h3cck 658 10 monitors monitor VBZ cord-267475-6f4h3cck 658 11 the the DT cord-267475-6f4h3cck 658 12 initiation initiation NN cord-267475-6f4h3cck 658 13 step step NN cord-267475-6f4h3cck 658 14 of of IN cord-267475-6f4h3cck 658 15 translation translation NN cord-267475-6f4h3cck 658 16 ( ( -LRB- cord-267475-6f4h3cck 658 17 Kozak Kozak NNP cord-267475-6f4h3cck 658 18 , , , cord-267475-6f4h3cck 658 19 1997 1997 CD cord-267475-6f4h3cck 658 20 ) ) -RRB- cord-267475-6f4h3cck 658 21 . . . cord-267475-6f4h3cck 659 1 The the DT cord-267475-6f4h3cck 659 2 scanning scanning NN cord-267475-6f4h3cck 659 3 mechanism mechanism NN cord-267475-6f4h3cck 659 4 predicts predict VBZ cord-267475-6f4h3cck 659 5 that that IN cord-267475-6f4h3cck 659 6 a a DT cord-267475-6f4h3cck 659 7 mutation mutation NN cord-267475-6f4h3cck 659 8 which which WDT cord-267475-6f4h3cck 659 9 weakens weaken VBZ cord-267475-6f4h3cck 659 10 or or CC cord-267475-6f4h3cck 659 11 destroys destroy VBZ cord-267475-6f4h3cck 659 12 the the DT cord-267475-6f4h3cck 659 13 normal normal JJ cord-267475-6f4h3cck 659 14 start start NN cord-267475-6f4h3cck 659 15 codon codon NN cord-267475-6f4h3cck 659 16 should should MD cord-267475-6f4h3cck 659 17 activate activate VB cord-267475-6f4h3cck 659 18 initiation initiation NN cord-267475-6f4h3cck 659 19 from from IN cord-267475-6f4h3cck 659 20 the the DT cord-267475-6f4h3cck 659 21 next next JJ cord-267475-6f4h3cck 659 22 AUG AUG NNP cord-267475-6f4h3cck 659 23 downstream downstream NN cord-267475-6f4h3cck 659 24 . . . cord-267475-6f4h3cck 660 1 In in IN cord-267475-6f4h3cck 660 2 some some DT cord-267475-6f4h3cck 660 3 hereditary hereditary JJ cord-267475-6f4h3cck 660 4 diseases disease NNS cord-267475-6f4h3cck 660 5 in in IN cord-267475-6f4h3cck 660 6 which which WDT cord-267475-6f4h3cck 660 7 the the DT cord-267475-6f4h3cck 660 8 AUG AUG NNP cord-267475-6f4h3cck 660 9 START START NNP cord-267475-6f4h3cck 660 10 codon codon NN cord-267475-6f4h3cck 660 11 is be VBZ cord-267475-6f4h3cck 660 12 ablated ablate VBN cord-267475-6f4h3cck 660 13 , , , cord-267475-6f4h3cck 660 14 a a DT cord-267475-6f4h3cck 660 15 truncated truncated JJ cord-267475-6f4h3cck 660 16 protein protein NN cord-267475-6f4h3cck 660 17 is be VBZ cord-267475-6f4h3cck 660 18 indeed indeed RB cord-267475-6f4h3cck 660 19 produced produce VBN cord-267475-6f4h3cck 660 20 in in IN cord-267475-6f4h3cck 660 21 this this DT cord-267475-6f4h3cck 660 22 way way NN cord-267475-6f4h3cck 661 1 but but CC cord-267475-6f4h3cck 661 2 it -PRON- PRP cord-267475-6f4h3cck 661 3 does do VBZ cord-267475-6f4h3cck 661 4 not not RB cord-267475-6f4h3cck 661 5 function function VB cord-267475-6f4h3cck 661 6 well well RB cord-267475-6f4h3cck 661 7 enough enough RB cord-267475-6f4h3cck 661 8 to to TO cord-267475-6f4h3cck 661 9 prevent prevent VB cord-267475-6f4h3cck 661 10 the the DT cord-267475-6f4h3cck 661 11 disease disease NN cord-267475-6f4h3cck 662 1 ( ( -LRB- cord-267475-6f4h3cck 662 2 Cahana Cahana NNP cord-267475-6f4h3cck 662 3 et et FW cord-267475-6f4h3cck 662 4 al al NNP cord-267475-6f4h3cck 662 5 . . . cord-267475-6f4h3cck 663 1 , , , cord-267475-6f4h3cck 663 2 2001 2001 CD cord-267475-6f4h3cck 663 3 ; ; : cord-267475-6f4h3cck 663 4 Huang Huang NNP cord-267475-6f4h3cck 663 5 et et NNP cord-267475-6f4h3cck 663 6 al al NNP cord-267475-6f4h3cck 663 7 . . . cord-267475-6f4h3cck 664 1 , , , cord-267475-6f4h3cck 664 2 1999 1999 CD cord-267475-6f4h3cck 664 3 ; ; : cord-267475-6f4h3cck 664 4 O'Neill O'Neill NNP cord-267475-6f4h3cck 664 5 et et NNP cord-267475-6f4h3cck 664 6 al al NNP cord-267475-6f4h3cck 664 7 . . NNP cord-267475-6f4h3cck 664 8 , , , cord-267475-6f4h3cck 664 9 2001 2001 CD cord-267475-6f4h3cck 664 10 ) ) -RRB- cord-267475-6f4h3cck 664 11 . . . cord-267475-6f4h3cck 665 1 In in IN cord-267475-6f4h3cck 665 2 the the DT cord-267475-6f4h3cck 665 3 case case NN cord-267475-6f4h3cck 665 4 of of IN cord-267475-6f4h3cck 665 5 a a DT cord-267475-6f4h3cck 665 6 mutated mutate VBN cord-267475-6f4h3cck 665 7 vasopressin vasopressin NN cord-267475-6f4h3cck 665 8 gene gene NN cord-267475-6f4h3cck 665 9 in in IN cord-267475-6f4h3cck 665 10 which which WDT cord-267475-6f4h3cck 665 11 the the DT cord-267475-6f4h3cck 665 12 G g NN cord-267475-6f4h3cck 665 13 of of IN cord-267475-6f4h3cck 665 14 the the DT cord-267475-6f4h3cck 665 15 AUG AUG NNP cord-267475-6f4h3cck 665 16 START START NNP cord-267475-6f4h3cck 665 17 codon codon NN cord-267475-6f4h3cck 665 18 is be VBZ cord-267475-6f4h3cck 665 19 deleted delete VBN cord-267475-6f4h3cck 665 20 , , , cord-267475-6f4h3cck 665 21 the the DT cord-267475-6f4h3cck 665 22 shorter short JJR cord-267475-6f4h3cck 665 23 signal signal NN cord-267475-6f4h3cck 665 24 peptide peptide NN cord-267475-6f4h3cck 665 25 initiated initiate VBD cord-267475-6f4h3cck 665 26 from from IN cord-267475-6f4h3cck 665 27 the the DT cord-267475-6f4h3cck 665 28 second second JJ cord-267475-6f4h3cck 665 29 AUG AUG NNP cord-267475-6f4h3cck 665 30 codon codon NN cord-267475-6f4h3cck 665 31 is be VBZ cord-267475-6f4h3cck 665 32 not not RB cord-267475-6f4h3cck 665 33 recognized recognize VBN cord-267475-6f4h3cck 665 34 by by IN cord-267475-6f4h3cck 665 35 signal signal NN cord-267475-6f4h3cck 665 36 peptidase peptidase NN cord-267475-6f4h3cck 665 37 ( ( -LRB- cord-267475-6f4h3cck 665 38 Beuret Beuret NNP cord-267475-6f4h3cck 665 39 et et NNP cord-267475-6f4h3cck 665 40 al al NNP cord-267475-6f4h3cck 665 41 . . NNP cord-267475-6f4h3cck 665 42 , , , cord-267475-6f4h3cck 665 43 1999 1999 CD cord-267475-6f4h3cck 665 44 ) ) -RRB- cord-267475-6f4h3cck 665 45 . . . cord-267475-6f4h3cck 666 1 The the DT cord-267475-6f4h3cck 666 2 resulting result VBG cord-267475-6f4h3cck 666 3 uncleaved uncleaved JJ cord-267475-6f4h3cck 666 4 vasopressin vasopressin NN cord-267475-6f4h3cck 666 5 - - HYPH cord-267475-6f4h3cck 666 6 precursor precursor NN cord-267475-6f4h3cck 666 7 protein protein NN cord-267475-6f4h3cck 666 8 folds fold VBZ cord-267475-6f4h3cck 666 9 incorrectly incorrectly RB cord-267475-6f4h3cck 666 10 , , , cord-267475-6f4h3cck 666 11 causing cause VBG cord-267475-6f4h3cck 666 12 subsequent subsequent JJ cord-267475-6f4h3cck 666 13 processing processing NN cord-267475-6f4h3cck 666 14 steps step NNS cord-267475-6f4h3cck 666 15 to to TO cord-267475-6f4h3cck 666 16 fail fail VB cord-267475-6f4h3cck 666 17 , , , cord-267475-6f4h3cck 666 18 and and CC cord-267475-6f4h3cck 666 19 therefore therefore RB cord-267475-6f4h3cck 666 20 vasopressin vasopressin NNP cord-267475-6f4h3cck 666 21 never never RB cord-267475-6f4h3cck 666 22 gets get VBZ cord-267475-6f4h3cck 666 23 released release VBN cord-267475-6f4h3cck 666 24 from from IN cord-267475-6f4h3cck 666 25 the the DT cord-267475-6f4h3cck 666 26 endoplasmic endoplasmic NN cord-267475-6f4h3cck 666 27 reticulum reticulum NN cord-267475-6f4h3cck 666 28 . . . cord-267475-6f4h3cck 667 1 The the DT cord-267475-6f4h3cck 667 2 second second JJ cord-267475-6f4h3cck 667 3 AUG AUG NNP cord-267475-6f4h3cck 667 4 is be VBZ cord-267475-6f4h3cck 667 5 only only RB cord-267475-6f4h3cck 667 6 four four CD cord-267475-6f4h3cck 667 7 codons codon NNS cord-267475-6f4h3cck 667 8 downstream downstream RB cord-267475-6f4h3cck 667 9 from from IN cord-267475-6f4h3cck 667 10 the the DT cord-267475-6f4h3cck 667 11 first first JJ cord-267475-6f4h3cck 667 12 , , , cord-267475-6f4h3cck 667 13 but but CC cord-267475-6f4h3cck 667 14 the the DT cord-267475-6f4h3cck 667 15 processing processing NN cord-267475-6f4h3cck 667 16 defect defect NN cord-267475-6f4h3cck 667 17 caused cause VBN cord-267475-6f4h3cck 667 18 by by IN cord-267475-6f4h3cck 667 19 this this DT cord-267475-6f4h3cck 667 20 slight slight JJ cord-267475-6f4h3cck 667 21 shift shift NN cord-267475-6f4h3cck 667 22 in in IN cord-267475-6f4h3cck 667 23 the the DT cord-267475-6f4h3cck 667 24 site site NN cord-267475-6f4h3cck 667 25 of of IN cord-267475-6f4h3cck 667 26 initiation initiation NN cord-267475-6f4h3cck 667 27 causes cause VBZ cord-267475-6f4h3cck 667 28 diabetes diabetes NN cord-267475-6f4h3cck 667 29 insipidus insipidus NN cord-267475-6f4h3cck 667 30 . . . cord-267475-6f4h3cck 668 1 The the DT cord-267475-6f4h3cck 668 2 scanning scanning NN cord-267475-6f4h3cck 668 3 mechanism mechanism NN cord-267475-6f4h3cck 668 4 predicts predict VBZ cord-267475-6f4h3cck 668 5 that that IN cord-267475-6f4h3cck 668 6 , , , cord-267475-6f4h3cck 668 7 when when WRB cord-267475-6f4h3cck 668 8 an an DT cord-267475-6f4h3cck 668 9 out out JJ cord-267475-6f4h3cck 668 10 - - HYPH cord-267475-6f4h3cck 668 11 offrame offrame NN cord-267475-6f4h3cck 668 12 AUG AUG NNP cord-267475-6f4h3cck 668 13 codon codon NN cord-267475-6f4h3cck 668 14 is be VBZ cord-267475-6f4h3cck 668 15 introduced introduce VBN cord-267475-6f4h3cck 668 16 into into IN cord-267475-6f4h3cck 668 17 the the DT cord-267475-6f4h3cck 668 18 5 5 CD cord-267475-6f4h3cck 668 19 0 0 CD cord-267475-6f4h3cck 668 20 UTR UTR NNP cord-267475-6f4h3cck 668 21 , , , cord-267475-6f4h3cck 668 22 the the DT cord-267475-6f4h3cck 668 23 adventitious adventitious JJ cord-267475-6f4h3cck 668 24 upstream upstream NN cord-267475-6f4h3cck 668 25 start start NN cord-267475-6f4h3cck 668 26 codon codon NN cord-267475-6f4h3cck 668 27 should should MD cord-267475-6f4h3cck 668 28 supplant supplant VB cord-267475-6f4h3cck 668 29 the the DT cord-267475-6f4h3cck 668 30 normal normal JJ cord-267475-6f4h3cck 668 31 start start NN cord-267475-6f4h3cck 668 32 site site NN cord-267475-6f4h3cck 668 33 . . . cord-267475-6f4h3cck 669 1 A a DT cord-267475-6f4h3cck 669 2 number number NN cord-267475-6f4h3cck 669 3 of of IN cord-267475-6f4h3cck 669 4 pathologies pathology NNS cord-267475-6f4h3cck 669 5 result result VBP cord-267475-6f4h3cck 669 6 from from IN cord-267475-6f4h3cck 669 7 this this DT cord-267475-6f4h3cck 669 8 kind kind NN cord-267475-6f4h3cck 669 9 of of IN cord-267475-6f4h3cck 669 10 translational translational JJ cord-267475-6f4h3cck 669 11 block block NN cord-267475-6f4h3cck 669 12 . . . cord-267475-6f4h3cck 670 1 Sometimes sometimes RB cord-267475-6f4h3cck 670 2 the the DT cord-267475-6f4h3cck 670 3 upstream upstream JJ cord-267475-6f4h3cck 670 4 AUG AUG NNP cord-267475-6f4h3cck 670 5 codon codon NN cord-267475-6f4h3cck 670 6 is be VBZ cord-267475-6f4h3cck 670 7 created create VBN cord-267475-6f4h3cck 670 8 by by IN cord-267475-6f4h3cck 670 9 a a DT cord-267475-6f4h3cck 670 10 rare rare JJ cord-267475-6f4h3cck 670 11 mutation mutation NN cord-267475-6f4h3cck 670 12 ( ( -LRB- cord-267475-6f4h3cck 670 13 Cai Cai NNP cord-267475-6f4h3cck 670 14 et et FW cord-267475-6f4h3cck 670 15 al al NNP cord-267475-6f4h3cck 670 16 . . NNP cord-267475-6f4h3cck 670 17 , , , cord-267475-6f4h3cck 670 18 1992 1992 CD cord-267475-6f4h3cck 670 19 ; ; : cord-267475-6f4h3cck 670 20 Liu Liu NNP cord-267475-6f4h3cck 670 21 et et NNP cord-267475-6f4h3cck 670 22 al al NNP cord-267475-6f4h3cck 670 23 . . NNP cord-267475-6f4h3cck 670 24 , , , cord-267475-6f4h3cck 670 25 1999 1999 CD cord-267475-6f4h3cck 670 26 ) ) -RRB- cord-267475-6f4h3cck 670 27 . . . cord-267475-6f4h3cck 671 1 Other other JJ cord-267475-6f4h3cck 671 2 times time NNS cord-267475-6f4h3cck 671 3 it -PRON- PRP cord-267475-6f4h3cck 671 4 derives derive VBZ cord-267475-6f4h3cck 671 5 from from IN cord-267475-6f4h3cck 671 6 a a DT cord-267475-6f4h3cck 671 7 common common JJ cord-267475-6f4h3cck 671 8 polymorphism polymorphism NN cord-267475-6f4h3cck 671 9 ( ( -LRB- cord-267475-6f4h3cck 671 10 Bergenhem Bergenhem NNP cord-267475-6f4h3cck 671 11 et et NNP cord-267475-6f4h3cck 671 12 al al NNP cord-267475-6f4h3cck 671 13 . . NNP cord-267475-6f4h3cck 671 14 , , , cord-267475-6f4h3cck 671 15 1992 1992 CD cord-267475-6f4h3cck 671 16 ; ; : cord-267475-6f4h3cck 671 17 Endler Endler NNP cord-267475-6f4h3cck 671 18 et et NNP cord-267475-6f4h3cck 671 19 al al NNP cord-267475-6f4h3cck 671 20 . . . cord-267475-6f4h3cck 672 1 , , , cord-267475-6f4h3cck 672 2 2001 2001 CD cord-267475-6f4h3cck 672 3 ; ; : cord-267475-6f4h3cck 672 4 Kanaji Kanaji NNP cord-267475-6f4h3cck 672 5 et et NNP cord-267475-6f4h3cck 672 6 al al NNP cord-267475-6f4h3cck 672 7 . . NNP cord-267475-6f4h3cck 672 8 , , , cord-267475-6f4h3cck 672 9 1998 1998 CD cord-267475-6f4h3cck 673 1 ; ; : cord-267475-6f4h3cck 673 2 Kraft Kraft NNP cord-267475-6f4h3cck 673 3 et et NNP cord-267475-6f4h3cck 673 4 al al NNP cord-267475-6f4h3cck 673 5 . . NNP cord-267475-6f4h3cck 673 6 , , , cord-267475-6f4h3cck 673 7 1998 1998 CD cord-267475-6f4h3cck 673 8 ; ; : cord-267475-6f4h3cck 673 9 Zysow Zysow NNP cord-267475-6f4h3cck 673 10 et et FW cord-267475-6f4h3cck 673 11 al al NNP cord-267475-6f4h3cck 673 12 . . NNP cord-267475-6f4h3cck 673 13 , , , cord-267475-6f4h3cck 673 14 1995 1995 CD cord-267475-6f4h3cck 673 15 ) ) -RRB- cord-267475-6f4h3cck 673 16 . . . cord-267475-6f4h3cck 674 1 The the DT cord-267475-6f4h3cck 674 2 reduction reduction NN cord-267475-6f4h3cck 674 3 in in IN cord-267475-6f4h3cck 674 4 translation translation NN cord-267475-6f4h3cck 674 5 is be VBZ cord-267475-6f4h3cck 674 6 more more RBR cord-267475-6f4h3cck 674 7 or or CC cord-267475-6f4h3cck 674 8 less less RBR cord-267475-6f4h3cck 674 9 severe severe JJ cord-267475-6f4h3cck 674 10 depending depending NN cord-267475-6f4h3cck 674 11 on on IN cord-267475-6f4h3cck 674 12 the the DT cord-267475-6f4h3cck 674 13 context context NN cord-267475-6f4h3cck 674 14 of of IN cord-267475-6f4h3cck 674 15 the the DT cord-267475-6f4h3cck 674 16 upstream upstream JJ cord-267475-6f4h3cck 674 17 AUG AUG NNP cord-267475-6f4h3cck 674 18 codon codon NN cord-267475-6f4h3cck 674 19 and and CC cord-267475-6f4h3cck 674 20 whether whether IN cord-267475-6f4h3cck 674 21 reinitiation reinitiation NN cord-267475-6f4h3cck 674 22 is be VBZ cord-267475-6f4h3cck 674 23 possible possible JJ cord-267475-6f4h3cck 674 24 . . . cord-267475-6f4h3cck 675 1 I -PRON- PRP cord-267475-6f4h3cck 675 2 have have VBP cord-267475-6f4h3cck 675 3 already already RB cord-267475-6f4h3cck 675 4 explained explain VBN cord-267475-6f4h3cck 675 5 how how WRB cord-267475-6f4h3cck 675 6 hereditary hereditary JJ cord-267475-6f4h3cck 675 7 thrombocythemia thrombocythemia NN cord-267475-6f4h3cck 675 8 is be VBZ cord-267475-6f4h3cck 675 9 caused cause VBN cord-267475-6f4h3cck 675 10 by by IN cord-267475-6f4h3cck 675 11 mutations mutation NNS cord-267475-6f4h3cck 675 12 that that WDT cord-267475-6f4h3cck 675 13 elevate elevate VBP cord-267475-6f4h3cck 675 14 translation translation NN cord-267475-6f4h3cck 675 15 of of IN cord-267475-6f4h3cck 675 16 TPO TPO NNP cord-267475-6f4h3cck 675 17 by by IN cord-267475-6f4h3cck 675 18 restructuring restructure VBG cord-267475-6f4h3cck 675 19 or or CC cord-267475-6f4h3cck 675 20 eliminating eliminate VBG cord-267475-6f4h3cck 675 21 an an DT cord-267475-6f4h3cck 675 22 inhibitory inhibitory JJ cord-267475-6f4h3cck 675 23 upORF upORF . cord-267475-6f4h3cck 676 1 ( ( -LRB- cord-267475-6f4h3cck 676 2 Fig Fig NNP cord-267475-6f4h3cck 676 3 . . . cord-267475-6f4h3cck 676 4 _SP cord-267475-6f4h3cck 676 5 4 4 CD cord-267475-6f4h3cck 676 6 ) ) -RRB- cord-267475-6f4h3cck 676 7 . . . cord-267475-6f4h3cck 677 1 Translation translation NN cord-267475-6f4h3cck 677 2 of of IN cord-267475-6f4h3cck 677 3 proto proto JJ cord-267475-6f4h3cck 677 4 - - HYPH cord-267475-6f4h3cck 677 5 oncogenes oncogenes NN cord-267475-6f4h3cck 677 6 is be VBZ cord-267475-6f4h3cck 677 7 also also RB cord-267475-6f4h3cck 677 8 elevated elevate VBN cord-267475-6f4h3cck 677 9 in in IN cord-267475-6f4h3cck 677 10 some some DT cord-267475-6f4h3cck 677 11 cases case NNS cord-267475-6f4h3cck 677 12 by by IN cord-267475-6f4h3cck 677 13 eliminating eliminate VBG cord-267475-6f4h3cck 677 14 small small JJ cord-267475-6f4h3cck 677 15 upORFs uporfs NN cord-267475-6f4h3cck 677 16 from from IN cord-267475-6f4h3cck 677 17 the the DT cord-267475-6f4h3cck 677 18 mRNA mrna NN cord-267475-6f4h3cck 677 19 . . . cord-267475-6f4h3cck 678 1 The the DT cord-267475-6f4h3cck 678 2 MDM2 MDM2 NNP cord-267475-6f4h3cck 678 3 oncogene oncogene NN cord-267475-6f4h3cck 678 4 is be VBZ cord-267475-6f4h3cck 678 5 one one CD cord-267475-6f4h3cck 678 6 example example NN cord-267475-6f4h3cck 678 7 : : : cord-267475-6f4h3cck 678 8 whereas whereas IN cord-267475-6f4h3cck 678 9 the the DT cord-267475-6f4h3cck 678 10 normal normal JJ cord-267475-6f4h3cck 678 11 mRNA mrna NN cord-267475-6f4h3cck 678 12 has have VBZ cord-267475-6f4h3cck 678 13 a a DT cord-267475-6f4h3cck 678 14 long long JJ cord-267475-6f4h3cck 678 15 5 5 CD cord-267475-6f4h3cck 678 16 0 0 CD cord-267475-6f4h3cck 678 17 UTR UTR NNP cord-267475-6f4h3cck 678 18 that that WDT cord-267475-6f4h3cck 678 19 includes include VBZ cord-267475-6f4h3cck 678 20 two two CD cord-267475-6f4h3cck 678 21 upstream upstream JJ cord-267475-6f4h3cck 678 22 AUG AUG NNP cord-267475-6f4h3cck 678 23 codons codon NNS cord-267475-6f4h3cck 678 24 , , , cord-267475-6f4h3cck 678 25 in in IN cord-267475-6f4h3cck 678 26 tumor tumor NN cord-267475-6f4h3cck 678 27 cells cell NNS cord-267475-6f4h3cck 678 28 the the DT cord-267475-6f4h3cck 678 29 use use NN cord-267475-6f4h3cck 678 30 of of IN cord-267475-6f4h3cck 678 31 a a DT cord-267475-6f4h3cck 678 32 different different JJ cord-267475-6f4h3cck 678 33 promoter promoter NN cord-267475-6f4h3cck 678 34 eliminates eliminate VBZ cord-267475-6f4h3cck 678 35 the the DT cord-267475-6f4h3cck 678 36 upstream upstream JJ cord-267475-6f4h3cck 678 37 AUGs aug NNS cord-267475-6f4h3cck 678 38 and and CC cord-267475-6f4h3cck 678 39 thus thus RB cord-267475-6f4h3cck 678 40 increases increase VBZ cord-267475-6f4h3cck 678 41 translational translational JJ cord-267475-6f4h3cck 678 42 efficiency efficiency NN cord-267475-6f4h3cck 679 1 20-fold 20-fold JJ cord-267475-6f4h3cck 679 2 ( ( -LRB- cord-267475-6f4h3cck 679 3 Brown Brown NNP cord-267475-6f4h3cck 679 4 et et NNP cord-267475-6f4h3cck 679 5 al al NNP cord-267475-6f4h3cck 679 6 . . . cord-267475-6f4h3cck 680 1 , , , cord-267475-6f4h3cck 680 2 1999 1999 CD cord-267475-6f4h3cck 680 3 ; ; : cord-267475-6f4h3cck 680 4 Landers Landers NNP cord-267475-6f4h3cck 680 5 et et NNP cord-267475-6f4h3cck 680 6 al al NNP cord-267475-6f4h3cck 680 7 . . NNP cord-267475-6f4h3cck 680 8 , , , cord-267475-6f4h3cck 680 9 1997 1997 CD cord-267475-6f4h3cck 680 10 ) ) -RRB- cord-267475-6f4h3cck 680 11 . . . cord-267475-6f4h3cck 681 1 In in IN cord-267475-6f4h3cck 681 2 the the DT cord-267475-6f4h3cck 681 3 case case NN cord-267475-6f4h3cck 681 4 of of IN cord-267475-6f4h3cck 681 5 oncogene oncogene NN cord-267475-6f4h3cck 681 6 GLI1 GLI1 NNP cord-267475-6f4h3cck 681 7 , , , cord-267475-6f4h3cck 681 8 the the DT cord-267475-6f4h3cck 681 9 upstream upstream JJ cord-267475-6f4h3cck 681 10 AUG AUG NNP cord-267475-6f4h3cck 681 11 codons codon NNS cord-267475-6f4h3cck 681 12 that that WDT cord-267475-6f4h3cck 681 13 restrict restrict VBP cord-267475-6f4h3cck 681 14 translation translation NN cord-267475-6f4h3cck 681 15 in in IN cord-267475-6f4h3cck 681 16 normal normal JJ cord-267475-6f4h3cck 681 17 cells cell NNS cord-267475-6f4h3cck 681 18 reside reside VBP cord-267475-6f4h3cck 681 19 in in IN cord-267475-6f4h3cck 681 20 an an DT cord-267475-6f4h3cck 681 21 intron intron NN cord-267475-6f4h3cck 681 22 which which WDT cord-267475-6f4h3cck 681 23 is be VBZ cord-267475-6f4h3cck 681 24 eliminated eliminate VBN cord-267475-6f4h3cck 681 25 by by IN cord-267475-6f4h3cck 681 26 more more RBR cord-267475-6f4h3cck 681 27 efficient efficient JJ cord-267475-6f4h3cck 681 28 splicing splicing NN cord-267475-6f4h3cck 681 29 in in IN cord-267475-6f4h3cck 681 30 basal basal NN cord-267475-6f4h3cck 681 31 cell cell NN cord-267475-6f4h3cck 681 32 carcinomas carcinoma NNS cord-267475-6f4h3cck 681 33 ( ( -LRB- cord-267475-6f4h3cck 681 34 Wang Wang NNP cord-267475-6f4h3cck 681 35 and and CC cord-267475-6f4h3cck 681 36 Rothnagel Rothnagel NNP cord-267475-6f4h3cck 681 37 , , , cord-267475-6f4h3cck 681 38 2001 2001 CD cord-267475-6f4h3cck 681 39 ) ) -RRB- cord-267475-6f4h3cck 681 40 . . . cord-267475-6f4h3cck 682 1 Translation translation NN cord-267475-6f4h3cck 682 2 of of IN cord-267475-6f4h3cck 682 3 many many JJ cord-267475-6f4h3cck 682 4 other other JJ cord-267475-6f4h3cck 682 5 human human JJ cord-267475-6f4h3cck 682 6 or or CC cord-267475-6f4h3cck 682 7 rodent rodent NN cord-267475-6f4h3cck 682 8 oncogenes oncogene NNS cord-267475-6f4h3cck 682 9 is be VBZ cord-267475-6f4h3cck 682 10 restricted restrict VBN cord-267475-6f4h3cck 682 11 in in IN cord-267475-6f4h3cck 682 12 normal normal JJ cord-267475-6f4h3cck 682 13 cells cell NNS cord-267475-6f4h3cck 682 14 by by IN cord-267475-6f4h3cck 682 15 an an DT cord-267475-6f4h3cck 682 16 encumbered encumbered JJ cord-267475-6f4h3cck 682 17 ( ( -LRB- cord-267475-6f4h3cck 682 18 AUG aug NN cord-267475-6f4h3cck 682 19 - - HYPH cord-267475-6f4h3cck 682 20 burdened burden VBN cord-267475-6f4h3cck 682 21 or or CC cord-267475-6f4h3cck 682 22 GC gc NN cord-267475-6f4h3cck 682 23 - - HYPH cord-267475-6f4h3cck 682 24 rich rich JJ cord-267475-6f4h3cck 682 25 ) ) -RRB- cord-267475-6f4h3cck 682 26 leader leader NN cord-267475-6f4h3cck 682 27 sequence sequence NN cord-267475-6f4h3cck 682 28 ( ( -LRB- cord-267475-6f4h3cck 682 29 Arrick Arrick NNP cord-267475-6f4h3cck 682 30 et et NNP cord-267475-6f4h3cck 682 31 al al NNP cord-267475-6f4h3cck 682 32 . . NNP cord-267475-6f4h3cck 682 33 , , , cord-267475-6f4h3cck 682 34 1991 1991 CD cord-267475-6f4h3cck 682 35 ; ; : cord-267475-6f4h3cck 682 36 Bates Bates NNP cord-267475-6f4h3cck 682 37 et et NNP cord-267475-6f4h3cck 682 38 al al NNP cord-267475-6f4h3cck 682 39 . . NNP cord-267475-6f4h3cck 682 40 , , , cord-267475-6f4h3cck 682 41 1991 1991 CD cord-267475-6f4h3cck 682 42 ; ; : cord-267475-6f4h3cck 682 43 Child Child NNP cord-267475-6f4h3cck 682 44 et et NNP cord-267475-6f4h3cck 682 45 al al NNP cord-267475-6f4h3cck 682 46 . . NNP cord-267475-6f4h3cck 682 47 , , , cord-267475-6f4h3cck 682 48 1999a 1999a CD cord-267475-6f4h3cck 682 49 ; ; : cord-267475-6f4h3cck 682 50 Harigai Harigai NNP cord-267475-6f4h3cck 682 51 et et NNP cord-267475-6f4h3cck 682 52 al al NNP cord-267475-6f4h3cck 682 53 . . NNP cord-267475-6f4h3cck 682 54 , , , cord-267475-6f4h3cck 682 55 1996 1996 CD cord-267475-6f4h3cck 682 56 ; ; : cord-267475-6f4h3cck 682 57 Hoover Hoover NNP cord-267475-6f4h3cck 682 58 et et NNP cord-267475-6f4h3cck 682 59 al al NNP cord-267475-6f4h3cck 682 60 . . NNP cord-267475-6f4h3cck 682 61 , , , cord-267475-6f4h3cck 682 62 1997 1997 CD cord-267475-6f4h3cck 682 63 ; ; : cord-267475-6f4h3cck 682 64 Horvath Horvath NNP cord-267475-6f4h3cck 682 65 et et NNP cord-267475-6f4h3cck 682 66 al al NNP cord-267475-6f4h3cck 682 67 . . NNP cord-267475-6f4h3cck 682 68 , , , cord-267475-6f4h3cck 682 69 1995 1995 CD cord-267475-6f4h3cck 682 70 ; ; : cord-267475-6f4h3cck 682 71 Manzella Manzella NNP cord-267475-6f4h3cck 682 72 and and CC cord-267475-6f4h3cck 682 73 Blackshear Blackshear NNP cord-267475-6f4h3cck 682 74 , , , cord-267475-6f4h3cck 682 75 1990 1990 CD cord-267475-6f4h3cck 682 76 ; ; : cord-267475-6f4h3cck 682 77 Sarrazin Sarrazin NNP cord-267475-6f4h3cck 682 78 et et NNP cord-267475-6f4h3cck 682 79 al al NNP cord-267475-6f4h3cck 682 80 . . NNP cord-267475-6f4h3cck 682 81 , , , cord-267475-6f4h3cck 682 82 2000 2000 CD cord-267475-6f4h3cck 682 83 ) ) -RRB- cord-267475-6f4h3cck 682 84 ; ; : cord-267475-6f4h3cck 682 85 in in IN cord-267475-6f4h3cck 682 86 some some DT cord-267475-6f4h3cck 682 87 of of IN cord-267475-6f4h3cck 682 88 these these DT cord-267475-6f4h3cck 682 89 cases case NNS cord-267475-6f4h3cck 682 90 , , , cord-267475-6f4h3cck 682 91 a a DT cord-267475-6f4h3cck 682 92 shorter short JJR cord-267475-6f4h3cck 682 93 5 5 CD cord-267475-6f4h3cck 682 94 0 0 CD cord-267475-6f4h3cck 682 95 UTR UTR NNP cord-267475-6f4h3cck 682 96 that that WDT cord-267475-6f4h3cck 682 97 better well JJR cord-267475-6f4h3cck 682 98 supports support VBZ cord-267475-6f4h3cck 682 99 translation translation NN cord-267475-6f4h3cck 682 100 is be VBZ cord-267475-6f4h3cck 682 101 produced produce VBN cord-267475-6f4h3cck 682 102 in in IN cord-267475-6f4h3cck 682 103 transformed transformed JJ cord-267475-6f4h3cck 682 104 cells cell NNS cord-267475-6f4h3cck 682 105 ( ( -LRB- cord-267475-6f4h3cck 682 106 Arrick Arrick NNP cord-267475-6f4h3cck 682 107 et et NNP cord-267475-6f4h3cck 682 108 al al NNP cord-267475-6f4h3cck 682 109 . . NNP cord-267475-6f4h3cck 682 110 , , , cord-267475-6f4h3cck 682 111 1994 1994 CD cord-267475-6f4h3cck 682 112 ; ; : cord-267475-6f4h3cck 682 113 Marth Marth NNP cord-267475-6f4h3cck 682 114 et et NNP cord-267475-6f4h3cck 682 115 al al NNP cord-267475-6f4h3cck 682 116 . . NNP cord-267475-6f4h3cck 682 117 , , , cord-267475-6f4h3cck 682 118 1988 1988 CD cord-267475-6f4h3cck 682 119 ) ) -RRB- cord-267475-6f4h3cck 682 120 . . . cord-267475-6f4h3cck 683 1 For for IN cord-267475-6f4h3cck 683 2 other other JJ cord-267475-6f4h3cck 683 3 oncogenes oncogene NNS cord-267475-6f4h3cck 683 4 , , , cord-267475-6f4h3cck 683 5 although although IN cord-267475-6f4h3cck 683 6 there there EX cord-267475-6f4h3cck 683 7 are be VBP cord-267475-6f4h3cck 683 8 alternative alternative JJ cord-267475-6f4h3cck 683 9 leader leader NN cord-267475-6f4h3cck 683 10 sequences sequence NNS cord-267475-6f4h3cck 683 11 that that WDT cord-267475-6f4h3cck 683 12 might may MD cord-267475-6f4h3cck 683 13 regulate regulate VB cord-267475-6f4h3cck 683 14 expression expression NN cord-267475-6f4h3cck 683 15 in in IN cord-267475-6f4h3cck 683 16 normal normal JJ cord-267475-6f4h3cck 683 17 tissues tissue NNS cord-267475-6f4h3cck 684 1 ( ( -LRB- cord-267475-6f4h3cck 684 2 Link link NN cord-267475-6f4h3cck 684 3 et et FW cord-267475-6f4h3cck 684 4 al al NNP cord-267475-6f4h3cck 684 5 . . NNP cord-267475-6f4h3cck 684 6 , , , cord-267475-6f4h3cck 684 7 1992 1992 CD cord-267475-6f4h3cck 685 1 ; ; : cord-267475-6f4h3cck 685 2 Sasahara Sasahara NNP cord-267475-6f4h3cck 685 3 et et NNP cord-267475-6f4h3cck 685 4 al al NNP cord-267475-6f4h3cck 685 5 . . NNP cord-267475-6f4h3cck 685 6 , , , cord-267475-6f4h3cck 685 7 1998 1998 CD cord-267475-6f4h3cck 685 8 ) ) -RRB- cord-267475-6f4h3cck 685 9 , , , cord-267475-6f4h3cck 685 10 there there EX cord-267475-6f4h3cck 685 11 is be VBZ cord-267475-6f4h3cck 685 12 no no DT cord-267475-6f4h3cck 685 13 evidence evidence NN cord-267475-6f4h3cck 685 14 that that IN cord-267475-6f4h3cck 685 15 switching switch VBG cord-267475-6f4h3cck 685 16 leader leader NN cord-267475-6f4h3cck 685 17 sequences sequence NNS cord-267475-6f4h3cck 685 18 contributes contribute VBZ cord-267475-6f4h3cck 685 19 to to IN cord-267475-6f4h3cck 685 20 tumorigenesis tumorigenesis NN cord-267475-6f4h3cck 685 21 . . . cord-267475-6f4h3cck 686 1 Table table NN cord-267475-6f4h3cck 686 2 4 4 CD cord-267475-6f4h3cck 686 3 Pathologies Pathologies NNPS cord-267475-6f4h3cck 686 4 resulting result VBG cord-267475-6f4h3cck 686 5 from from IN cord-267475-6f4h3cck 686 6 a a DT cord-267475-6f4h3cck 686 7 change change NN cord-267475-6f4h3cck 686 8 in in IN cord-267475-6f4h3cck 686 9 mRNA mRNA NNP cord-267475-6f4h3cck 686 10 structure structure NN cord-267475-6f4h3cck 686 11 which which WDT cord-267475-6f4h3cck 686 12 selectively selectively RB cord-267475-6f4h3cck 686 13 abolishes abolish VBZ cord-267475-6f4h3cck 686 14 production production NN cord-267475-6f4h3cck 686 15 of of IN cord-267475-6f4h3cck 686 16 the the DT cord-267475-6f4h3cck 686 17 long long JJ cord-267475-6f4h3cck 686 18 or or CC cord-267475-6f4h3cck 686 19 short short JJ cord-267475-6f4h3cck 686 20 form form NN cord-267475-6f4h3cck 686 21 of of IN cord-267475-6f4h3cck 686 22 a a DT cord-267475-6f4h3cck 686 23 transcription transcription NN cord-267475-6f4h3cck 686 24 factor factor NN cord-267475-6f4h3cck 686 25 Translational translational JJ cord-267475-6f4h3cck 686 26 mechanism mechanism NN cord-267475-6f4h3cck 686 27 that that WDT cord-267475-6f4h3cck 686 28 normally normally RB cord-267475-6f4h3cck 686 29 generates generate VBZ cord-267475-6f4h3cck 686 30 two two CD cord-267475-6f4h3cck 686 31 protein protein NN cord-267475-6f4h3cck 686 32 isoforms isoform NNS cord-267475-6f4h3cck 686 33 Disease Disease NNP cord-267475-6f4h3cck 686 34 - - HYPH cord-267475-6f4h3cck 686 35 associated associate VBN cord-267475-6f4h3cck 686 36 change change NN cord-267475-6f4h3cck 686 37 in in IN cord-267475-6f4h3cck 686 38 mRNA mRNA NNP cord-267475-6f4h3cck 686 39 structure structure NN cord-267475-6f4h3cck 686 40 and and CC cord-267475-6f4h3cck 686 41 translation translation NN cord-267475-6f4h3cck 687 1 References reference NNS cord-267475-6f4h3cck 687 2 C C NNP cord-267475-6f4h3cck 687 3 / / SYM cord-267475-6f4h3cck 687 4 EBPa EBPa NNS cord-267475-6f4h3cck 687 5 ( ( -LRB- cord-267475-6f4h3cck 687 6 human human NN cord-267475-6f4h3cck 687 7 ) ) -RRB- cord-267475-6f4h3cck 687 8 Two two CD cord-267475-6f4h3cck 687 9 proteins protein NNS cord-267475-6f4h3cck 687 10 from from IN cord-267475-6f4h3cck 687 11 one one CD cord-267475-6f4h3cck 687 12 mRNA mrna NN cord-267475-6f4h3cck 687 13 via via IN cord-267475-6f4h3cck 687 14 leaky leaky JJ cord-267475-6f4h3cck 687 15 scanning scanning NN cord-267475-6f4h3cck 687 16 þ þ NNP cord-267475-6f4h3cck 687 17 reinitiation reinitiation NN cord-267475-6f4h3cck 687 18 shunt shunt NN cord-267475-6f4h3cck 688 1 In in IN cord-267475-6f4h3cck 688 2 acute acute JJ cord-267475-6f4h3cck 688 3 myeloid myeloid NN cord-267475-6f4h3cck 688 4 leukemia leukemia NN cord-267475-6f4h3cck 688 5 , , , cord-267475-6f4h3cck 688 6 mutations mutation NNS cord-267475-6f4h3cck 688 7 near near IN cord-267475-6f4h3cck 688 8 amino amino NN cord-267475-6f4h3cck 688 9 terminus terminus NN cord-267475-6f4h3cck 688 10 eliminate eliminate VBP cord-267475-6f4h3cck 688 11 production production NN cord-267475-6f4h3cck 688 12 of of IN cord-267475-6f4h3cck 688 13 longer long JJR cord-267475-6f4h3cck 688 14 isoform isoform NN cord-267475-6f4h3cck 688 15 . . . cord-267475-6f4h3cck 689 1 Pabst Pabst NNP cord-267475-6f4h3cck 689 2 et et NNP cord-267475-6f4h3cck 689 3 al al NNP cord-267475-6f4h3cck 689 4 . . . cord-267475-6f4h3cck 690 1 , , , cord-267475-6f4h3cck 690 2 2001 2001 CD cord-267475-6f4h3cck 690 3 GATA1 gata1 XX cord-267475-6f4h3cck 691 1 ( ( -LRB- cord-267475-6f4h3cck 691 2 human human NN cord-267475-6f4h3cck 691 3 ) ) -RRB- cord-267475-6f4h3cck 692 1 Two two CD cord-267475-6f4h3cck 692 2 proteins protein NNS cord-267475-6f4h3cck 692 3 from from IN cord-267475-6f4h3cck 692 4 one one CD cord-267475-6f4h3cck 692 5 mRNA mrna NN cord-267475-6f4h3cck 692 6 via via IN cord-267475-6f4h3cck 692 7 leaky leaky JJ cord-267475-6f4h3cck 692 8 scanning scanning NN cord-267475-6f4h3cck 692 9 In in IN cord-267475-6f4h3cck 692 10 Down Down NNP cord-267475-6f4h3cck 692 11 syndrome syndrome NN cord-267475-6f4h3cck 692 12 - - HYPH cord-267475-6f4h3cck 692 13 related relate VBN cord-267475-6f4h3cck 692 14 leukemia leukemia NN cord-267475-6f4h3cck 693 1 , , , cord-267475-6f4h3cck 693 2 premature premature JJ cord-267475-6f4h3cck 693 3 stop stop NN cord-267475-6f4h3cck 693 4 codon codon NN cord-267475-6f4h3cck 693 5 eliminates eliminate VBZ cord-267475-6f4h3cck 693 6 production production NN cord-267475-6f4h3cck 693 7 of of IN cord-267475-6f4h3cck 693 8 longer long JJR cord-267475-6f4h3cck 693 9 isoform isoform NN cord-267475-6f4h3cck 693 10 . . . cord-267475-6f4h3cck 694 1 Wechsler Wechsler NNP cord-267475-6f4h3cck 694 2 et et NNP cord-267475-6f4h3cck 694 3 al al NNP cord-267475-6f4h3cck 694 4 . . NNP cord-267475-6f4h3cck 694 5 , , , cord-267475-6f4h3cck 694 6 2002 2002 CD cord-267475-6f4h3cck 694 7 LEF1 LEF1 NNP cord-267475-6f4h3cck 694 8 ( ( -LRB- cord-267475-6f4h3cck 694 9 human human NN cord-267475-6f4h3cck 694 10 ) ) -RRB- cord-267475-6f4h3cck 695 1 Two two CD cord-267475-6f4h3cck 695 2 proteins protein NNS cord-267475-6f4h3cck 695 3 from from IN cord-267475-6f4h3cck 695 4 two two CD cord-267475-6f4h3cck 695 5 mRNAs mrna NNS cord-267475-6f4h3cck 696 1 ( ( -LRB- cord-267475-6f4h3cck 696 2 via via IN cord-267475-6f4h3cck 696 3 two two CD cord-267475-6f4h3cck 696 4 promoters promoter NNS cord-267475-6f4h3cck 696 5 ) ) -RRB- cord-267475-6f4h3cck 697 1 In in IN cord-267475-6f4h3cck 697 2 colon colon NN cord-267475-6f4h3cck 697 3 cancer cancer NN cord-267475-6f4h3cck 697 4 , , , cord-267475-6f4h3cck 697 5 failure failure NN cord-267475-6f4h3cck 697 6 to to TO cord-267475-6f4h3cck 697 7 activate activate VB cord-267475-6f4h3cck 697 8 downstream downstream JJ cord-267475-6f4h3cck 697 9 promoter promoter NN cord-267475-6f4h3cck 697 10 prevents prevent VBZ cord-267475-6f4h3cck 697 11 production production NN cord-267475-6f4h3cck 697 12 of of IN cord-267475-6f4h3cck 697 13 shorter short JJR cord-267475-6f4h3cck 697 14 ( ( -LRB- cord-267475-6f4h3cck 697 15 inhibitory inhibitory JJ cord-267475-6f4h3cck 697 16 ) ) -RRB- cord-267475-6f4h3cck 697 17 isoform isoform NN cord-267475-6f4h3cck 697 18 . . . cord-267475-6f4h3cck 698 1 Hovanes Hovanes NNP cord-267475-6f4h3cck 698 2 et et NNP cord-267475-6f4h3cck 698 3 al al NNP cord-267475-6f4h3cck 698 4 . . . cord-267475-6f4h3cck 699 1 , , , cord-267475-6f4h3cck 699 2 2001 2001 CD cord-267475-6f4h3cck 699 3 Rx Rx NNP cord-267475-6f4h3cck 699 4 / / SYM cord-267475-6f4h3cck 699 5 rax rax NNP cord-267475-6f4h3cck 699 6 ( ( -LRB- cord-267475-6f4h3cck 699 7 mouse mouse NN cord-267475-6f4h3cck 699 8 ) ) -RRB- cord-267475-6f4h3cck 700 1 Two two CD cord-267475-6f4h3cck 700 2 proteins protein NNS cord-267475-6f4h3cck 700 3 from from IN cord-267475-6f4h3cck 700 4 one one CD cord-267475-6f4h3cck 700 5 mRNA mrna NN cord-267475-6f4h3cck 700 6 via via IN cord-267475-6f4h3cck 700 7 leaky leaky JJ cord-267475-6f4h3cck 700 8 scanning scanning NN cord-267475-6f4h3cck 701 1 a a LS cord-267475-6f4h3cck 702 1 In in IN cord-267475-6f4h3cck 702 2 eyeless eyeless JJ cord-267475-6f4h3cck 702 3 mice mouse NNS cord-267475-6f4h3cck 702 4 , , , cord-267475-6f4h3cck 702 5 mutation mutation NN cord-267475-6f4h3cck 702 6 of of IN cord-267475-6f4h3cck 702 7 second second JJ cord-267475-6f4h3cck 702 8 AUG AUG NNP cord-267475-6f4h3cck 702 9 , , , cord-267475-6f4h3cck 702 10 leaving leave VBG cord-267475-6f4h3cck 702 11 only only RB cord-267475-6f4h3cck 702 12 the the DT cord-267475-6f4h3cck 702 13 weak weak JJ cord-267475-6f4h3cck 702 14 upstream upstream JJ cord-267475-6f4h3cck 702 15 start start NN cord-267475-6f4h3cck 702 16 codon codon NN cord-267475-6f4h3cck 702 17 , , , cord-267475-6f4h3cck 702 18 results result NNS cord-267475-6f4h3cck 702 19 in in IN cord-267475-6f4h3cck 702 20 inadequate inadequate JJ cord-267475-6f4h3cck 702 21 yield yield NN cord-267475-6f4h3cck 702 22 . . . cord-267475-6f4h3cck 703 1 Tucker Tucker NNP cord-267475-6f4h3cck 703 2 et et NNP cord-267475-6f4h3cck 703 3 al al NNP cord-267475-6f4h3cck 703 4 . . . cord-267475-6f4h3cck 704 1 , , , cord-267475-6f4h3cck 704 2 2001 2001 CD cord-267475-6f4h3cck 705 1 a a LS cord-267475-6f4h3cck 705 2 Here here RB cord-267475-6f4h3cck 705 3 the the DT cord-267475-6f4h3cck 705 4 long long JJ cord-267475-6f4h3cck 705 5 and and CC cord-267475-6f4h3cck 705 6 short short JJ cord-267475-6f4h3cck 705 7 isoforms isoform NNS cord-267475-6f4h3cck 705 8 appear appear VBP cord-267475-6f4h3cck 705 9 to to TO cord-267475-6f4h3cck 705 10 function function VB cord-267475-6f4h3cck 705 11 identically identically RB cord-267475-6f4h3cck 705 12 ; ; : cord-267475-6f4h3cck 705 13 the the DT cord-267475-6f4h3cck 705 14 significance significance NN cord-267475-6f4h3cck 705 15 of of IN cord-267475-6f4h3cck 705 16 the the DT cord-267475-6f4h3cck 705 17 second second JJ cord-267475-6f4h3cck 705 18 AUG AUG NNP cord-267475-6f4h3cck 705 19 START START NNP cord-267475-6f4h3cck 705 20 codon codon NN cord-267475-6f4h3cck 705 21 pertains pertain VBZ cord-267475-6f4h3cck 705 22 to to IN cord-267475-6f4h3cck 705 23 boosting boost VBG cord-267475-6f4h3cck 705 24 the the DT cord-267475-6f4h3cck 705 25 overall overall JJ cord-267475-6f4h3cck 705 26 protein protein NN cord-267475-6f4h3cck 705 27 yield yield NN cord-267475-6f4h3cck 705 28 . . . cord-267475-6f4h3cck 706 1 The the DT cord-267475-6f4h3cck 706 2 eyeless eyeless JJ cord-267475-6f4h3cck 706 3 mouse mouse NN cord-267475-6f4h3cck 706 4 serves serve VBZ cord-267475-6f4h3cck 706 5 as as IN cord-267475-6f4h3cck 706 6 a a DT cord-267475-6f4h3cck 706 7 spontaneous spontaneous JJ cord-267475-6f4h3cck 706 8 model model NN cord-267475-6f4h3cck 706 9 for for IN cord-267475-6f4h3cck 706 10 human human JJ cord-267475-6f4h3cck 706 11 anophthalmia anophthalmia NNP cord-267475-6f4h3cck 706 12 . . . cord-267475-6f4h3cck 707 1 Whereas whereas IN cord-267475-6f4h3cck 707 2 removal removal NN cord-267475-6f4h3cck 707 3 of of IN cord-267475-6f4h3cck 707 4 small small JJ cord-267475-6f4h3cck 707 5 upORFs uporfs NN cord-267475-6f4h3cck 707 6 elevates elevate VBZ cord-267475-6f4h3cck 707 7 the the DT cord-267475-6f4h3cck 707 8 translation translation NN cord-267475-6f4h3cck 707 9 of of IN cord-267475-6f4h3cck 707 10 the the DT cord-267475-6f4h3cck 707 11 aforementioned aforementioned JJ cord-267475-6f4h3cck 707 12 MDM2 MDM2 NNP cord-267475-6f4h3cck 707 13 and and CC cord-267475-6f4h3cck 707 14 GLI1 GLI1 NNP cord-267475-6f4h3cck 707 15 oncogenes oncogene NNS cord-267475-6f4h3cck 707 16 in in IN cord-267475-6f4h3cck 707 17 tumor tumor NN cord-267475-6f4h3cck 707 18 cells cell NNS cord-267475-6f4h3cck 707 19 , , , cord-267475-6f4h3cck 707 20 addition addition NN cord-267475-6f4h3cck 707 21 of of IN cord-267475-6f4h3cck 707 22 small small JJ cord-267475-6f4h3cck 707 23 upORFs uporfs NN cord-267475-6f4h3cck 707 24 shuts shut NNS cord-267475-6f4h3cck 707 25 off off IN cord-267475-6f4h3cck 707 26 the the DT cord-267475-6f4h3cck 707 27 translation translation NN cord-267475-6f4h3cck 707 28 of of IN cord-267475-6f4h3cck 707 29 some some DT cord-267475-6f4h3cck 707 30 tumor tumor NN cord-267475-6f4h3cck 707 31 suppressor suppressor NN cord-267475-6f4h3cck 707 32 genes gene NNS cord-267475-6f4h3cck 707 33 . . . cord-267475-6f4h3cck 708 1 In in IN cord-267475-6f4h3cck 708 2 the the DT cord-267475-6f4h3cck 708 3 case case NN cord-267475-6f4h3cck 708 4 of of IN cord-267475-6f4h3cck 708 5 HYAL1 hyal1 NN cord-267475-6f4h3cck 708 6 , , , cord-267475-6f4h3cck 708 7 retention retention NN cord-267475-6f4h3cck 708 8 of of IN cord-267475-6f4h3cck 708 9 an an DT cord-267475-6f4h3cck 708 10 intron intron NN cord-267475-6f4h3cck 708 11 which which WDT cord-267475-6f4h3cck 708 12 contains contain VBZ cord-267475-6f4h3cck 708 13 eight eight CD cord-267475-6f4h3cck 708 14 upstream upstream JJ cord-267475-6f4h3cck 708 15 AUG AUG NNP cord-267475-6f4h3cck 708 16 codons codon NNS cord-267475-6f4h3cck 708 17 renders render VBZ cord-267475-6f4h3cck 708 18 the the DT cord-267475-6f4h3cck 708 19 mRNA mrna NN cord-267475-6f4h3cck 708 20 untranslatable untranslatable JJ cord-267475-6f4h3cck 708 21 in in IN cord-267475-6f4h3cck 708 22 squamous squamous JJ cord-267475-6f4h3cck 708 23 cell cell NN cord-267475-6f4h3cck 708 24 carcinomas carcinoma NNS cord-267475-6f4h3cck 709 1 ( ( -LRB- cord-267475-6f4h3cck 709 2 Frost Frost NNP cord-267475-6f4h3cck 709 3 et et NNP cord-267475-6f4h3cck 709 4 al al NNP cord-267475-6f4h3cck 709 5 . . NNP cord-267475-6f4h3cck 709 6 , , , cord-267475-6f4h3cck 709 7 2000 2000 CD cord-267475-6f4h3cck 709 8 ) ) -RRB- cord-267475-6f4h3cck 709 9 . . . cord-267475-6f4h3cck 710 1 A a DT cord-267475-6f4h3cck 710 2 striking striking JJ cord-267475-6f4h3cck 710 3 example example NN cord-267475-6f4h3cck 710 4 of of IN cord-267475-6f4h3cck 710 5 translational translational JJ cord-267475-6f4h3cck 710 6 inactivation inactivation NN cord-267475-6f4h3cck 710 7 of of IN cord-267475-6f4h3cck 710 8 a a DT cord-267475-6f4h3cck 710 9 tumor tumor NN cord-267475-6f4h3cck 710 10 suppressor suppressor NN cord-267475-6f4h3cck 710 11 gene gene NN cord-267475-6f4h3cck 710 12 is be VBZ cord-267475-6f4h3cck 710 13 seen see VBN cord-267475-6f4h3cck 710 14 in in IN cord-267475-6f4h3cck 710 15 some some DT cord-267475-6f4h3cck 710 16 individuals individual NNS cord-267475-6f4h3cck 710 17 with with IN cord-267475-6f4h3cck 710 18 a a DT cord-267475-6f4h3cck 710 19 predisposition predisposition NN cord-267475-6f4h3cck 710 20 to to IN cord-267475-6f4h3cck 710 21 melanoma melanoma NN cord-267475-6f4h3cck 710 22 . . . cord-267475-6f4h3cck 711 1 In in IN cord-267475-6f4h3cck 711 2 certain certain JJ cord-267475-6f4h3cck 711 3 families family NNS cord-267475-6f4h3cck 711 4 , , , cord-267475-6f4h3cck 711 5 a a DT cord-267475-6f4h3cck 711 6 point point NN cord-267475-6f4h3cck 711 7 mutation mutation NN cord-267475-6f4h3cck 711 8 ( ( -LRB- cord-267475-6f4h3cck 711 9 G g NN cord-267475-6f4h3cck 711 10 ! ! . cord-267475-6f4h3cck 711 11 T T NNP cord-267475-6f4h3cck 711 12 ) ) -RRB- cord-267475-6f4h3cck 711 13 creates create VBZ cord-267475-6f4h3cck 711 14 an an DT cord-267475-6f4h3cck 711 15 upstream upstream NN cord-267475-6f4h3cck 711 16 , , , cord-267475-6f4h3cck 711 17 out out RB cord-267475-6f4h3cck 711 18 - - HYPH cord-267475-6f4h3cck 711 19 of of IN cord-267475-6f4h3cck 711 20 - - HYPH cord-267475-6f4h3cck 711 21 frame frame NN cord-267475-6f4h3cck 711 22 AUG AUG NNP cord-267475-6f4h3cck 711 23 codon codon NN cord-267475-6f4h3cck 711 24 in in IN cord-267475-6f4h3cck 711 25 the the DT cord-267475-6f4h3cck 711 26 CDKN2 cdkn2 NN cord-267475-6f4h3cck 711 27 gene gene NN cord-267475-6f4h3cck 711 28 . . . cord-267475-6f4h3cck 712 1 The the DT cord-267475-6f4h3cck 712 2 small small JJ cord-267475-6f4h3cck 712 3 upORF uporf NN cord-267475-6f4h3cck 712 4 initiated initiate VBN cord-267475-6f4h3cck 712 5 from from IN cord-267475-6f4h3cck 712 6 this this DT cord-267475-6f4h3cck 712 7 new new JJ cord-267475-6f4h3cck 712 8 AUG AUG NNP cord-267475-6f4h3cck 712 9 codon codon NN cord-267475-6f4h3cck 712 10 overlaps overlap VBZ cord-267475-6f4h3cck 712 11 the the DT cord-267475-6f4h3cck 712 12 CDKN2 cdkn2 NN cord-267475-6f4h3cck 712 13 start start NN cord-267475-6f4h3cck 712 14 codon codon NN cord-267475-6f4h3cck 712 15 , , , cord-267475-6f4h3cck 712 16 and and CC cord-267475-6f4h3cck 712 17 the the DT cord-267475-6f4h3cck 712 18 resulting result VBG cord-267475-6f4h3cck 712 19 inhibition inhibition NN cord-267475-6f4h3cck 712 20 of of IN cord-267475-6f4h3cck 712 21 translation translation NN cord-267475-6f4h3cck 712 22 is be VBZ cord-267475-6f4h3cck 712 23 profound profound JJ cord-267475-6f4h3cck 712 24 . . . cord-267475-6f4h3cck 713 1 Structural structural JJ cord-267475-6f4h3cck 713 2 changes change NNS cord-267475-6f4h3cck 713 3 that that WDT cord-267475-6f4h3cck 713 4 attenuate attenuate VBP cord-267475-6f4h3cck 713 5 the the DT cord-267475-6f4h3cck 713 6 translation translation NN cord-267475-6f4h3cck 713 7 of of IN cord-267475-6f4h3cck 713 8 viral viral JJ cord-267475-6f4h3cck 713 9 mRNAs mRNAs NNPS cord-267475-6f4h3cck 713 10 can can MD cord-267475-6f4h3cck 713 11 contribute contribute VB cord-267475-6f4h3cck 713 12 to to IN cord-267475-6f4h3cck 713 13 the the DT cord-267475-6f4h3cck 713 14 development development NN cord-267475-6f4h3cck 713 15 of of IN cord-267475-6f4h3cck 713 16 persistent persistent JJ cord-267475-6f4h3cck 713 17 infections infection NNS cord-267475-6f4h3cck 713 18 . . . cord-267475-6f4h3cck 714 1 The the DT cord-267475-6f4h3cck 714 2 5 5 CD cord-267475-6f4h3cck 714 3 0 0 CD cord-267475-6f4h3cck 714 4 leader leader NN cord-267475-6f4h3cck 714 5 sequence sequence NN cord-267475-6f4h3cck 714 6 on on IN cord-267475-6f4h3cck 714 7 bovine bovine JJ cord-267475-6f4h3cck 714 8 coronavirus coronavirus NN cord-267475-6f4h3cck 714 9 mRNAs mRNAs '' cord-267475-6f4h3cck 714 10 , , , cord-267475-6f4h3cck 714 11 for for IN cord-267475-6f4h3cck 714 12 example example NN cord-267475-6f4h3cck 714 13 , , , cord-267475-6f4h3cck 714 14 was be VBD cord-267475-6f4h3cck 714 15 found find VBN cord-267475-6f4h3cck 714 16 to to TO cord-267475-6f4h3cck 714 17 evolve evolve VB cord-267475-6f4h3cck 714 18 -by -by NFP cord-267475-6f4h3cck 714 19 acquiring acquire VBG cord-267475-6f4h3cck 714 20 a a DT cord-267475-6f4h3cck 714 21 small small JJ cord-267475-6f4h3cck 714 22 upORF upORF . cord-267475-6f4h3cck 715 1 -during -dure VBG cord-267475-6f4h3cck 716 1 the the DT cord-267475-6f4h3cck 716 2 course course NN cord-267475-6f4h3cck 716 3 of of IN cord-267475-6f4h3cck 716 4 establishing establish VBG cord-267475-6f4h3cck 716 5 a a DT cord-267475-6f4h3cck 716 6 persistent persistent JJ cord-267475-6f4h3cck 716 7 infection infection NN cord-267475-6f4h3cck 716 8 ( ( -LRB- cord-267475-6f4h3cck 716 9 Hofmann Hofmann NNP cord-267475-6f4h3cck 716 10 et et NNP cord-267475-6f4h3cck 716 11 al al NNP cord-267475-6f4h3cck 716 12 . . NNP cord-267475-6f4h3cck 716 13 , , , cord-267475-6f4h3cck 716 14 1993 1993 CD cord-267475-6f4h3cck 716 15 ) ) -RRB- cord-267475-6f4h3cck 716 16 . . . cord-267475-6f4h3cck 717 1 Shishido Shishido NNP cord-267475-6f4h3cck 717 2 - - HYPH cord-267475-6f4h3cck 717 3 Hara Hara NNP cord-267475-6f4h3cck 717 4 et et NNP cord-267475-6f4h3cck 717 5 al al NNP cord-267475-6f4h3cck 717 6 . . . cord-267475-6f4h3cck 718 1 ( ( -LRB- cord-267475-6f4h3cck 718 2 2000 2000 CD cord-267475-6f4h3cck 718 3 ) ) -RRB- cord-267475-6f4h3cck 718 4 speculate speculate VBP cord-267475-6f4h3cck 718 5 that that IN cord-267475-6f4h3cck 718 6 human human JJ cord-267475-6f4h3cck 718 7 polyomavirus polyomavirus JJ cord-267475-6f4h3cck 718 8 JC JC NNP cord-267475-6f4h3cck 718 9 might may MD cord-267475-6f4h3cck 718 10 cause cause VB cord-267475-6f4h3cck 718 11 persistent persistent JJ cord-267475-6f4h3cck 718 12 rather rather RB cord-267475-6f4h3cck 718 13 than than IN cord-267475-6f4h3cck 718 14 acute acute JJ cord-267475-6f4h3cck 718 15 infection infection NN cord-267475-6f4h3cck 718 16 because because IN cord-267475-6f4h3cck 718 17 all all DT cord-267475-6f4h3cck 718 18 capsid capsid NN cord-267475-6f4h3cck 718 19 - - HYPH cord-267475-6f4h3cck 718 20 protein protein NN cord-267475-6f4h3cck 718 21 encoding encoding NN cord-267475-6f4h3cck 718 22 transcripts transcript NNS cord-267475-6f4h3cck 718 23 produced produce VBN cord-267475-6f4h3cck 718 24 by by IN cord-267475-6f4h3cck 718 25 the the DT cord-267475-6f4h3cck 718 26 JC JC NNP cord-267475-6f4h3cck 718 27 virus virus NN cord-267475-6f4h3cck 718 28 have have VBP cord-267475-6f4h3cck 718 29 a a DT cord-267475-6f4h3cck 718 30 small small JJ cord-267475-6f4h3cck 718 31 upORF uporf NN cord-267475-6f4h3cck 718 32 . . . cord-267475-6f4h3cck 719 1 With with IN cord-267475-6f4h3cck 719 2 the the DT cord-267475-6f4h3cck 719 3 related relate VBN cord-267475-6f4h3cck 719 4 simian simian JJ cord-267475-6f4h3cck 719 5 virus virus NN cord-267475-6f4h3cck 719 6 40 40 CD cord-267475-6f4h3cck 719 7 , , , cord-267475-6f4h3cck 719 8 in in IN cord-267475-6f4h3cck 719 9 contrast contrast NN cord-267475-6f4h3cck 719 10 , , , cord-267475-6f4h3cck 719 11 the the DT cord-267475-6f4h3cck 719 12 upORF uporf JJ cord-267475-6f4h3cck 719 13 is be VBZ cord-267475-6f4h3cck 719 14 sometimes sometimes RB cord-267475-6f4h3cck 719 15 eliminated eliminate VBN cord-267475-6f4h3cck 719 16 by by IN cord-267475-6f4h3cck 719 17 splicing splice VBG cord-267475-6f4h3cck 719 18 , , , cord-267475-6f4h3cck 719 19 generating generate VBG cord-267475-6f4h3cck 719 20 transcripts transcript NNS cord-267475-6f4h3cck 719 21 that that WDT cord-267475-6f4h3cck 719 22 better well JJR cord-267475-6f4h3cck 719 23 support support NN cord-267475-6f4h3cck 719 24 translation translation NN cord-267475-6f4h3cck 719 25 of of IN cord-267475-6f4h3cck 719 26 the the DT cord-267475-6f4h3cck 719 27 major major JJ cord-267475-6f4h3cck 719 28 capsid capsid NN cord-267475-6f4h3cck 719 29 protein protein NN cord-267475-6f4h3cck 719 30 . . . cord-267475-6f4h3cck 720 1 Attenuating attenuate VBG cord-267475-6f4h3cck 720 2 effects effect NNS cord-267475-6f4h3cck 720 3 caused cause VBN cord-267475-6f4h3cck 720 4 by by IN cord-267475-6f4h3cck 720 5 introducing introduce VBG cord-267475-6f4h3cck 720 6 an an DT cord-267475-6f4h3cck 720 7 upstream upstream JJ cord-267475-6f4h3cck 720 8 AUG AUG NNP cord-267475-6f4h3cck 720 9 codon codon NN cord-267475-6f4h3cck 720 10 have have VBP cord-267475-6f4h3cck 720 11 been be VBN cord-267475-6f4h3cck 720 12 described describe VBN cord-267475-6f4h3cck 720 13 also also RB cord-267475-6f4h3cck 720 14 with with IN cord-267475-6f4h3cck 720 15 other other JJ cord-267475-6f4h3cck 720 16 viruses virus NNS cord-267475-6f4h3cck 720 17 ( ( -LRB- cord-267475-6f4h3cck 720 18 Petty Petty NNP cord-267475-6f4h3cck 720 19 et et NNP cord-267475-6f4h3cck 720 20 al al NNP cord-267475-6f4h3cck 720 21 . . NNP cord-267475-6f4h3cck 720 22 , , , cord-267475-6f4h3cck 720 23 1990 1990 CD cord-267475-6f4h3cck 720 24 ; ; : cord-267475-6f4h3cck 720 25 Slobodskaya Slobodskaya NNP cord-267475-6f4h3cck 720 26 et et NNP cord-267475-6f4h3cck 720 27 al al NNP cord-267475-6f4h3cck 720 28 . . NNP cord-267475-6f4h3cck 720 29 , , , cord-267475-6f4h3cck 720 30 1996 1996 CD cord-267475-6f4h3cck 720 31 ) ) -RRB- cord-267475-6f4h3cck 720 32 . . . cord-267475-6f4h3cck 721 1 A a DT cord-267475-6f4h3cck 721 2 more more RBR cord-267475-6f4h3cck 721 3 drastic drastic JJ cord-267475-6f4h3cck 721 4 restructuring restructuring NN cord-267475-6f4h3cck 721 5 of of IN cord-267475-6f4h3cck 721 6 mRNAs mrnas CD cord-267475-6f4h3cck 721 7 sometimes sometimes RB cord-267475-6f4h3cck 721 8 occurs occur VBZ cord-267475-6f4h3cck 721 9 during during IN cord-267475-6f4h3cck 721 10 the the DT cord-267475-6f4h3cck 721 11 establishment establishment NN cord-267475-6f4h3cck 721 12 of of IN cord-267475-6f4h3cck 721 13 persistent persistent JJ cord-267475-6f4h3cck 721 14 infections infection NNS cord-267475-6f4h3cck 721 15 by by IN cord-267475-6f4h3cck 721 16 the the DT cord-267475-6f4h3cck 721 17 measles measle NNS cord-267475-6f4h3cck 721 18 virus virus NN cord-267475-6f4h3cck 721 19 . . . cord-267475-6f4h3cck 722 1 Instead instead RB cord-267475-6f4h3cck 722 2 of of IN cord-267475-6f4h3cck 722 3 the the DT cord-267475-6f4h3cck 722 4 normal normal JJ cord-267475-6f4h3cck 722 5 monocistronic monocistronic NN cord-267475-6f4h3cck 722 6 mRNA mrna NN cord-267475-6f4h3cck 722 7 for for IN cord-267475-6f4h3cck 722 8 the the DT cord-267475-6f4h3cck 722 9 fusion fusion NN cord-267475-6f4h3cck 722 10 protein protein NN cord-267475-6f4h3cck 722 11 , , , cord-267475-6f4h3cck 722 12 the the DT cord-267475-6f4h3cck 722 13 predominant predominant JJ cord-267475-6f4h3cck 722 14 transcript transcript NN cord-267475-6f4h3cck 722 15 in in IN cord-267475-6f4h3cck 722 16 some some DT cord-267475-6f4h3cck 722 17 persistently persistently RB cord-267475-6f4h3cck 722 18 infected infected JJ cord-267475-6f4h3cck 722 19 cells cell NNS cord-267475-6f4h3cck 722 20 was be VBD cord-267475-6f4h3cck 722 21 a a DT cord-267475-6f4h3cck 722 22 dicistronic dicistronic JJ cord-267475-6f4h3cck 722 23 mRNA mrna NN cord-267475-6f4h3cck 722 24 from from IN cord-267475-6f4h3cck 722 25 which which WDT cord-267475-6f4h3cck 722 26 the the DT cord-267475-6f4h3cck 722 27 F F NNP cord-267475-6f4h3cck 722 28 cistron cistron NN cord-267475-6f4h3cck 722 29 , , , cord-267475-6f4h3cck 722 30 located locate VBN cord-267475-6f4h3cck 722 31 at at IN cord-267475-6f4h3cck 722 32 the the DT cord-267475-6f4h3cck 722 33 3 3 CD cord-267475-6f4h3cck 722 34 0 0 CD cord-267475-6f4h3cck 722 35 end end NN cord-267475-6f4h3cck 722 36 , , , cord-267475-6f4h3cck 722 37 could could MD cord-267475-6f4h3cck 722 38 not not RB cord-267475-6f4h3cck 722 39 be be VB cord-267475-6f4h3cck 722 40 translated translate VBN cord-267475-6f4h3cck 722 41 ( ( -LRB- cord-267475-6f4h3cck 723 1 Hummel Hummel NNP cord-267475-6f4h3cck 723 2 et et NNP cord-267475-6f4h3cck 723 3 al al NNP cord-267475-6f4h3cck 723 4 . . NNP cord-267475-6f4h3cck 723 5 , , , cord-267475-6f4h3cck 723 6 1994 1994 CD cord-267475-6f4h3cck 723 7 ) ) -RRB- cord-267475-6f4h3cck 723 8 . . . cord-267475-6f4h3cck 724 1 A a DT cord-267475-6f4h3cck 724 2 similar similar JJ cord-267475-6f4h3cck 724 3 problem problem NN cord-267475-6f4h3cck 724 4 encountered encounter VBN cord-267475-6f4h3cck 724 5 in in IN cord-267475-6f4h3cck 724 6 studies study NNS cord-267475-6f4h3cck 724 7 with with IN cord-267475-6f4h3cck 724 8 recombinant recombinant JJ cord-267475-6f4h3cck 724 9 rhabdoviruses rhabdovirus NNS cord-267475-6f4h3cck 724 10 provides provide VBZ cord-267475-6f4h3cck 724 11 insight insight NN cord-267475-6f4h3cck 724 12 into into IN cord-267475-6f4h3cck 724 13 the the DT cord-267475-6f4h3cck 724 14 transcriptional transcriptional JJ cord-267475-6f4h3cck 724 15 defects defect NNS cord-267475-6f4h3cck 724 16 that that WDT cord-267475-6f4h3cck 724 17 can can MD cord-267475-6f4h3cck 724 18 generate generate VB cord-267475-6f4h3cck 724 19 untranslatable untranslatable JJ cord-267475-6f4h3cck 724 20 dicistronic dicistronic JJ cord-267475-6f4h3cck 724 21 mRNAs mRNAs . cord-267475-6f4h3cck 725 1 ( ( -LRB- cord-267475-6f4h3cck 725 2 Quiñones Quiñones NNP cord-267475-6f4h3cck 725 3 - - HYPH cord-267475-6f4h3cck 725 4 Kochs Kochs NNP cord-267475-6f4h3cck 725 5 et et FW cord-267475-6f4h3cck 725 6 al al NNP cord-267475-6f4h3cck 725 7 . . NNP cord-267475-6f4h3cck 725 8 , , , cord-267475-6f4h3cck 725 9 2001 2001 CD cord-267475-6f4h3cck 725 10 ) ) -RRB- cord-267475-6f4h3cck 725 11 . . . cord-267475-6f4h3cck 726 1 In in IN cord-267475-6f4h3cck 726 2 the the DT cord-267475-6f4h3cck 726 3 case case NN cord-267475-6f4h3cck 726 4 of of IN cord-267475-6f4h3cck 726 5 a a DT cord-267475-6f4h3cck 726 6 human human JJ cord-267475-6f4h3cck 726 7 parvovirus parvovirus NN cord-267475-6f4h3cck 726 8 , , , cord-267475-6f4h3cck 726 9 productive productive JJ cord-267475-6f4h3cck 726 10 infection infection NN cord-267475-6f4h3cck 726 11 is be VBZ cord-267475-6f4h3cck 726 12 restricted restrict VBN cord-267475-6f4h3cck 726 13 to to IN cord-267475-6f4h3cck 726 14 a a DT cord-267475-6f4h3cck 726 15 subset subset NN cord-267475-6f4h3cck 726 16 of of IN cord-267475-6f4h3cck 726 17 erythroid erythroid NN cord-267475-6f4h3cck 726 18 cells cell NNS cord-267475-6f4h3cck 726 19 in in IN cord-267475-6f4h3cck 726 20 which which WDT cord-267475-6f4h3cck 726 21 splicing splicing NN cord-267475-6f4h3cck 726 22 generates generate VBZ cord-267475-6f4h3cck 726 23 a a DT cord-267475-6f4h3cck 726 24 monocistronic monocistronic NN cord-267475-6f4h3cck 726 25 mRNA mrna NN cord-267475-6f4h3cck 726 26 for for IN cord-267475-6f4h3cck 726 27 each each DT cord-267475-6f4h3cck 726 28 of of IN cord-267475-6f4h3cck 726 29 the the DT cord-267475-6f4h3cck 726 30 major major JJ cord-267475-6f4h3cck 726 31 capsid capsid NN cord-267475-6f4h3cck 726 32 proteins protein NNS cord-267475-6f4h3cck 726 33 . . . cord-267475-6f4h3cck 727 1 In in IN cord-267475-6f4h3cck 727 2 nonpermissive nonpermissive JJ cord-267475-6f4h3cck 727 3 cells cell NNS cord-267475-6f4h3cck 727 4 , , , cord-267475-6f4h3cck 727 5 a a DT cord-267475-6f4h3cck 727 6 slight slight JJ cord-267475-6f4h3cck 727 7 shift shift NN cord-267475-6f4h3cck 727 8 in in IN cord-267475-6f4h3cck 727 9 the the DT cord-267475-6f4h3cck 727 10 position position NN cord-267475-6f4h3cck 727 11 of of IN cord-267475-6f4h3cck 727 12 a a DT cord-267475-6f4h3cck 727 13 splice splice NN cord-267475-6f4h3cck 727 14 site site NN cord-267475-6f4h3cck 727 15 imposes impose VBZ cord-267475-6f4h3cck 727 16 an an DT cord-267475-6f4h3cck 727 17 upstream upstream JJ cord-267475-6f4h3cck 727 18 ORF ORF NNP cord-267475-6f4h3cck 727 19 which which WDT cord-267475-6f4h3cck 727 20 is be VBZ cord-267475-6f4h3cck 727 21 postulated postulate VBN cord-267475-6f4h3cck 727 22 to to TO cord-267475-6f4h3cck 727 23 restrict restrict VB cord-267475-6f4h3cck 727 24 translation translation NN cord-267475-6f4h3cck 727 25 of of IN cord-267475-6f4h3cck 727 26 the the DT cord-267475-6f4h3cck 727 27 capsid capsid NN cord-267475-6f4h3cck 727 28 proteins protein NNS cord-267475-6f4h3cck 728 1 ( ( -LRB- cord-267475-6f4h3cck 728 2 Brunstein Brunstein NNP cord-267475-6f4h3cck 728 3 et et NNP cord-267475-6f4h3cck 728 4 al al NNP cord-267475-6f4h3cck 728 5 . . NNP cord-267475-6f4h3cck 728 6 , , , cord-267475-6f4h3cck 728 7 2000 2000 CD cord-267475-6f4h3cck 728 8 ) ) -RRB- cord-267475-6f4h3cck 728 9 . . . cord-267475-6f4h3cck 729 1 Translational translational JJ cord-267475-6f4h3cck 729 2 twists twist NNS cord-267475-6f4h3cck 729 3 sometimes sometimes RB cord-267475-6f4h3cck 729 4 generate generate VBP cord-267475-6f4h3cck 729 5 antigens antigen NNS cord-267475-6f4h3cck 729 6 which which WDT cord-267475-6f4h3cck 729 7 , , , cord-267475-6f4h3cck 729 8 by by IN cord-267475-6f4h3cck 729 9 stimulating stimulate VBG cord-267475-6f4h3cck 729 10 the the DT cord-267475-6f4h3cck 729 11 CTL CTL NNP cord-267475-6f4h3cck 729 12 response response NN cord-267475-6f4h3cck 729 13 , , , cord-267475-6f4h3cck 729 14 are be VBP cord-267475-6f4h3cck 729 15 important important JJ cord-267475-6f4h3cck 729 16 in in IN cord-267475-6f4h3cck 729 17 the the DT cord-267475-6f4h3cck 729 18 host host NN cord-267475-6f4h3cck 729 19 defense defense NN cord-267475-6f4h3cck 729 20 against against IN cord-267475-6f4h3cck 729 21 tumor tumor NN cord-267475-6f4h3cck 729 22 cells cell NNS cord-267475-6f4h3cck 729 23 and and CC cord-267475-6f4h3cck 729 24 viruses virus NNS cord-267475-6f4h3cck 730 1 ( ( -LRB- cord-267475-6f4h3cck 730 2 Shastri Shastri NNP cord-267475-6f4h3cck 730 3 et et NNP cord-267475-6f4h3cck 730 4 al al NNP cord-267475-6f4h3cck 730 5 . . NNP cord-267475-6f4h3cck 730 6 , , , cord-267475-6f4h3cck 730 7 2002 2002 CD cord-267475-6f4h3cck 730 8 ) ) -RRB- cord-267475-6f4h3cck 730 9 . . . cord-267475-6f4h3cck 731 1 Leaky leaky JJ cord-267475-6f4h3cck 731 2 scanning scanning NN cord-267475-6f4h3cck 731 3 is be VBZ cord-267475-6f4h3cck 731 4 a a DT cord-267475-6f4h3cck 731 5 likely likely JJ cord-267475-6f4h3cck 731 6 explanation explanation NN cord-267475-6f4h3cck 731 7 in in IN cord-267475-6f4h3cck 731 8 several several JJ cord-267475-6f4h3cck 731 9 cases case NNS cord-267475-6f4h3cck 731 10 where where WRB cord-267475-6f4h3cck 731 11 the the DT cord-267475-6f4h3cck 731 12 major major JJ cord-267475-6f4h3cck 731 13 ORF ORF NNP cord-267475-6f4h3cck 731 14 starts start VBZ cord-267475-6f4h3cck 731 15 with with IN cord-267475-6f4h3cck 731 16 an an DT cord-267475-6f4h3cck 731 17 AUG AUG NNP cord-267475-6f4h3cck 731 18 codon codon NN cord-267475-6f4h3cck 731 19 in in IN cord-267475-6f4h3cck 731 20 a a DT cord-267475-6f4h3cck 731 21 suboptimal suboptimal JJ cord-267475-6f4h3cck 731 22 context context NN cord-267475-6f4h3cck 731 23 and and CC cord-267475-6f4h3cck 731 24 the the DT cord-267475-6f4h3cck 731 25 CTL CTL NNP cord-267475-6f4h3cck 731 26 antigen antigen NN cord-267475-6f4h3cck 731 27 derives derive VBZ cord-267475-6f4h3cck 731 28 from from IN cord-267475-6f4h3cck 731 29 initiation initiation NN cord-267475-6f4h3cck 731 30 at at IN cord-267475-6f4h3cck 731 31 the the DT cord-267475-6f4h3cck 731 32 next next JJ cord-267475-6f4h3cck 731 33 ( ( -LRB- cord-267475-6f4h3cck 731 34 out out IN cord-267475-6f4h3cck 731 35 - - HYPH cord-267475-6f4h3cck 731 36 of of IN cord-267475-6f4h3cck 731 37 - - HYPH cord-267475-6f4h3cck 731 38 frame frame NN cord-267475-6f4h3cck 731 39 ) ) -RRB- cord-267475-6f4h3cck 731 40 AUG AUG NNP cord-267475-6f4h3cck 731 41 ( ( -LRB- cord-267475-6f4h3cck 731 42 Aarnoudse Aarnoudse NNP cord-267475-6f4h3cck 731 43 et et NNP cord-267475-6f4h3cck 731 44 al al NNP cord-267475-6f4h3cck 731 45 . . NNP cord-267475-6f4h3cck 731 46 , , , cord-267475-6f4h3cck 731 47 1999 1999 CD cord-267475-6f4h3cck 731 48 ; ; : cord-267475-6f4h3cck 731 49 Bullock Bullock NNP cord-267475-6f4h3cck 731 50 et et NNP cord-267475-6f4h3cck 731 51 al al NNP cord-267475-6f4h3cck 731 52 . . . cord-267475-6f4h3cck 732 1 , , , cord-267475-6f4h3cck 732 2 1997 1997 CD cord-267475-6f4h3cck 732 3 ; ; : cord-267475-6f4h3cck 732 4 Probst Probst NNP cord-267475-6f4h3cck 732 5 - - HYPH cord-267475-6f4h3cck 732 6 Kepper Kepper NNP cord-267475-6f4h3cck 732 7 et et FW cord-267475-6f4h3cck 732 8 al al NNP cord-267475-6f4h3cck 732 9 . . NNP cord-267475-6f4h3cck 732 10 , , , cord-267475-6f4h3cck 732 11 2001 2001 CD cord-267475-6f4h3cck 732 12 ; ; : cord-267475-6f4h3cck 733 1 Rimoldi Rimoldi NNP cord-267475-6f4h3cck 733 2 et et NNP cord-267475-6f4h3cck 733 3 al al NNP cord-267475-6f4h3cck 733 4 . . NNP cord-267475-6f4h3cck 733 5 , , , cord-267475-6f4h3cck 733 6 2000 2000 CD cord-267475-6f4h3cck 733 7 ) ) -RRB- cord-267475-6f4h3cck 733 8 . . . cord-267475-6f4h3cck 734 1 In in IN cord-267475-6f4h3cck 734 2 one one CD cord-267475-6f4h3cck 734 3 notable notable JJ cord-267475-6f4h3cck 734 4 case case NN cord-267475-6f4h3cck 734 5 , , , cord-267475-6f4h3cck 734 6 translation translation NN cord-267475-6f4h3cck 734 7 shifts shift NNS cord-267475-6f4h3cck 734 8 upstream upstream RB cord-267475-6f4h3cck 734 9 to to IN cord-267475-6f4h3cck 734 10 an an DT cord-267475-6f4h3cck 734 11 in in IN cord-267475-6f4h3cck 734 12 - - HYPH cord-267475-6f4h3cck 734 13 frame frame NN cord-267475-6f4h3cck 734 14 AUG AUG NNP cord-267475-6f4h3cck 734 15 codon codon NN cord-267475-6f4h3cck 734 16 created create VBN cord-267475-6f4h3cck 734 17 during during IN cord-267475-6f4h3cck 734 18 insertion insertion NN cord-267475-6f4h3cck 734 19 of of IN cord-267475-6f4h3cck 734 20 a a DT cord-267475-6f4h3cck 734 21 provirus provirus NN cord-267475-6f4h3cck 734 22 , , , cord-267475-6f4h3cck 734 23 and and CC cord-267475-6f4h3cck 734 24 the the DT cord-267475-6f4h3cck 734 25 resulting result VBG cord-267475-6f4h3cck 734 26 novel novel JJ cord-267475-6f4h3cck 734 27 N n CD cord-267475-6f4h3cck 734 28 - - HYPH cord-267475-6f4h3cck 734 29 terminal terminal NN cord-267475-6f4h3cck 734 30 amino amino NN cord-267475-6f4h3cck 734 31 acid acid NN cord-267475-6f4h3cck 734 32 extension extension NN cord-267475-6f4h3cck 734 33 functions function NNS cord-267475-6f4h3cck 734 34 as as IN cord-267475-6f4h3cck 734 35 a a DT cord-267475-6f4h3cck 734 36 tumor tumor NN cord-267475-6f4h3cck 734 37 rejection rejection NN cord-267475-6f4h3cck 734 38 antigen antigen NN cord-267475-6f4h3cck 734 39 ( ( -LRB- cord-267475-6f4h3cck 734 40 Wada Wada NNP cord-267475-6f4h3cck 734 41 et et FW cord-267475-6f4h3cck 734 42 al al NNP cord-267475-6f4h3cck 734 43 . . NNP cord-267475-6f4h3cck 734 44 , , , cord-267475-6f4h3cck 734 45 1995 1995 CD cord-267475-6f4h3cck 734 46 ) ) -RRB- cord-267475-6f4h3cck 734 47 . . . cord-267475-6f4h3cck 735 1 The the DT cord-267475-6f4h3cck 735 2 scanning scanning NN cord-267475-6f4h3cck 735 3 mechanism mechanism NN cord-267475-6f4h3cck 735 4 can can MD cord-267475-6f4h3cck 735 5 not not RB cord-267475-6f4h3cck 735 6 explain explain VB cord-267475-6f4h3cck 735 7 the the DT cord-267475-6f4h3cck 735 8 translation translation NN cord-267475-6f4h3cck 735 9 of of IN cord-267475-6f4h3cck 735 10 CTL CTL NNP cord-267475-6f4h3cck 735 11 antigens antigen NNS cord-267475-6f4h3cck 735 12 for for IN cord-267475-6f4h3cck 735 13 which which WDT cord-267475-6f4h3cck 735 14 the the DT cord-267475-6f4h3cck 735 15 start start NN cord-267475-6f4h3cck 735 16 codon codon NN cord-267475-6f4h3cck 735 17 resides reside VBZ cord-267475-6f4h3cck 735 18 far far RB cord-267475-6f4h3cck 735 19 in in IN cord-267475-6f4h3cck 735 20 the the DT cord-267475-6f4h3cck 735 21 interior interior NN cord-267475-6f4h3cck 735 22 of of IN cord-267475-6f4h3cck 735 23 the the DT cord-267475-6f4h3cck 735 24 mRNA mRNA NNP cord-267475-6f4h3cck 736 1 ( ( -LRB- cord-267475-6f4h3cck 736 2 Ronsin Ronsin NNP cord-267475-6f4h3cck 736 3 et et FW cord-267475-6f4h3cck 736 4 al al NNP cord-267475-6f4h3cck 736 5 . . NNP cord-267475-6f4h3cck 736 6 , , , cord-267475-6f4h3cck 736 7 1999 1999 CD cord-267475-6f4h3cck 736 8 ; ; : cord-267475-6f4h3cck 736 9 Wang Wang NNP cord-267475-6f4h3cck 736 10 et et NNP cord-267475-6f4h3cck 736 11 al al NNP cord-267475-6f4h3cck 736 12 . . NNP cord-267475-6f4h3cck 736 13 , , , cord-267475-6f4h3cck 736 14 1996 1996 CD cord-267475-6f4h3cck 736 15 ) ) -RRB- cord-267475-6f4h3cck 736 16 . . . cord-267475-6f4h3cck 737 1 In in IN cord-267475-6f4h3cck 737 2 these these DT cord-267475-6f4h3cck 737 3 cases case NNS cord-267475-6f4h3cck 737 4 the the DT cord-267475-6f4h3cck 737 5 antigenic antigenic JJ cord-267475-6f4h3cck 737 6 peptide peptide NN cord-267475-6f4h3cck 737 7 might may MD cord-267475-6f4h3cck 737 8 be be VB cord-267475-6f4h3cck 737 9 produced produce VBN cord-267475-6f4h3cck 737 10 from from IN cord-267475-6f4h3cck 737 11 an an DT cord-267475-6f4h3cck 737 12 undetected undetected JJ cord-267475-6f4h3cck 737 13 alternative alternative JJ cord-267475-6f4h3cck 737 14 form form NN cord-267475-6f4h3cck 737 15 of of IN cord-267475-6f4h3cck 737 16 mRNA mrna NN cord-267475-6f4h3cck 737 17 . . . cord-267475-6f4h3cck 738 1 Sensitive sensitive JJ cord-267475-6f4h3cck 738 2 new new JJ cord-267475-6f4h3cck 738 3 assay assay NN cord-267475-6f4h3cck 738 4 techniques technique NNS cord-267475-6f4h3cck 738 5 employed employ VBN cord-267475-6f4h3cck 738 6 with with IN cord-267475-6f4h3cck 738 7 some some DT cord-267475-6f4h3cck 738 8 genes gene NNS cord-267475-6f4h3cck 738 9 indeed indeed RB cord-267475-6f4h3cck 738 10 reveal reveal VBP cord-267475-6f4h3cck 738 11 an an DT cord-267475-6f4h3cck 738 12 array array NN cord-267475-6f4h3cck 738 13 of of IN cord-267475-6f4h3cck 738 14 alternative alternative JJ cord-267475-6f4h3cck 738 15 transcripts transcript NNS cord-267475-6f4h3cck 738 16 from from IN cord-267475-6f4h3cck 738 17 which which WDT cord-267475-6f4h3cck 738 18 novel novel JJ cord-267475-6f4h3cck 738 19 tumor tumor NN cord-267475-6f4h3cck 738 20 antigens antigen NNS cord-267475-6f4h3cck 738 21 can can MD cord-267475-6f4h3cck 738 22 be be VB cord-267475-6f4h3cck 738 23 translated translate VBN cord-267475-6f4h3cck 738 24 ( ( -LRB- cord-267475-6f4h3cck 738 25 Behrends Behrends NNP cord-267475-6f4h3cck 738 26 et et NNP cord-267475-6f4h3cck 738 27 al al NNP cord-267475-6f4h3cck 738 28 . . NNP cord-267475-6f4h3cck 738 29 , , , cord-267475-6f4h3cck 738 30 2002 2002 CD cord-267475-6f4h3cck 738 31 ) ) -RRB- cord-267475-6f4h3cck 738 32 . . . cord-267475-6f4h3cck 739 1 In in IN cord-267475-6f4h3cck 739 2 another another DT cord-267475-6f4h3cck 739 3 study study NN cord-267475-6f4h3cck 739 4 , , , cord-267475-6f4h3cck 739 5 a a DT cord-267475-6f4h3cck 739 6 potent potent JJ cord-267475-6f4h3cck 739 7 tumor tumor NN cord-267475-6f4h3cck 739 8 rejection rejection NN cord-267475-6f4h3cck 739 9 peptide peptide NN cord-267475-6f4h3cck 739 10 , , , cord-267475-6f4h3cck 739 11 which which WDT cord-267475-6f4h3cck 739 12 maps map VBZ cord-267475-6f4h3cck 739 13 to to IN cord-267475-6f4h3cck 739 14 an an DT cord-267475-6f4h3cck 739 15 internal internal JJ cord-267475-6f4h3cck 739 16 AUG AUG NNP cord-267475-6f4h3cck 739 17 codon codon NN cord-267475-6f4h3cck 739 18 in in IN cord-267475-6f4h3cck 739 19 the the DT cord-267475-6f4h3cck 739 20 full full JJ cord-267475-6f4h3cck 739 21 - - HYPH cord-267475-6f4h3cck 739 22 length length NN cord-267475-6f4h3cck 739 23 cDNA cdna NN cord-267475-6f4h3cck 739 24 , , , cord-267475-6f4h3cck 739 25 was be VBD cord-267475-6f4h3cck 739 26 expressed express VBN cord-267475-6f4h3cck 739 27 experimentally experimentally RB cord-267475-6f4h3cck 739 28 from from IN cord-267475-6f4h3cck 739 29 a a DT cord-267475-6f4h3cck 739 30 truncated truncated JJ cord-267475-6f4h3cck 739 31 cDNA cdna NN cord-267475-6f4h3cck 739 32 wherein wherein WRB cord-267475-6f4h3cck 739 33 the the DT cord-267475-6f4h3cck 739 34 start start NN cord-267475-6f4h3cck 739 35 codon codon NN cord-267475-6f4h3cck 739 36 for for IN cord-267475-6f4h3cck 739 37 the the DT cord-267475-6f4h3cck 739 38 antigenic antigenic JJ cord-267475-6f4h3cck 739 39 peptide peptide NN cord-267475-6f4h3cck 739 40 was be VBD cord-267475-6f4h3cck 739 41 made make VBN cord-267475-6f4h3cck 739 42 the the DT cord-267475-6f4h3cck 739 43 first first JJ cord-267475-6f4h3cck 739 44 AUG AUG NNP cord-267475-6f4h3cck 739 45 ( ( -LRB- cord-267475-6f4h3cck 739 46 Rosenberg Rosenberg NNP cord-267475-6f4h3cck 739 47 et et NNP cord-267475-6f4h3cck 739 48 al al NNP cord-267475-6f4h3cck 739 49 . . NNP cord-267475-6f4h3cck 739 50 , , , cord-267475-6f4h3cck 739 51 2002 2002 CD cord-267475-6f4h3cck 739 52 ) ) -RRB- cord-267475-6f4h3cck 739 53 . . . cord-267475-6f4h3cck 740 1 Additional additional JJ cord-267475-6f4h3cck 740 2 analyses analysis NNS cord-267475-6f4h3cck 740 3 are be VBP cord-267475-6f4h3cck 740 4 needed need VBN cord-267475-6f4h3cck 740 5 to to TO cord-267475-6f4h3cck 740 6 determine determine VB cord-267475-6f4h3cck 740 7 whether whether IN cord-267475-6f4h3cck 740 8 , , , cord-267475-6f4h3cck 740 9 in in IN cord-267475-6f4h3cck 740 10 the the DT cord-267475-6f4h3cck 740 11 melanoma melanoma NN cord-267475-6f4h3cck 740 12 cells cell NNS cord-267475-6f4h3cck 740 13 wherein wherein WRB cord-267475-6f4h3cck 740 14 this this DT cord-267475-6f4h3cck 740 15 antigen antigen NN cord-267475-6f4h3cck 740 16 is be VBZ cord-267475-6f4h3cck 740 17 expressed express VBN cord-267475-6f4h3cck 740 18 naturally naturally RB cord-267475-6f4h3cck 740 19 , , , cord-267475-6f4h3cck 740 20 a a DT cord-267475-6f4h3cck 740 21 transcript transcript NN cord-267475-6f4h3cck 740 22 similar similar JJ cord-267475-6f4h3cck 740 23 to to IN cord-267475-6f4h3cck 740 24 the the DT cord-267475-6f4h3cck 740 25 experimentally experimentally RB cord-267475-6f4h3cck 740 26 truncated truncate VBN cord-267475-6f4h3cck 740 27 cDNA cdna NN cord-267475-6f4h3cck 740 28 is be VBZ cord-267475-6f4h3cck 740 29 produced produce VBN cord-267475-6f4h3cck 740 30 via via IN cord-267475-6f4h3cck 740 31 a a DT cord-267475-6f4h3cck 740 32 downstream downstream JJ cord-267475-6f4h3cck 740 33 promoter promoter NN cord-267475-6f4h3cck 740 34 or or CC cord-267475-6f4h3cck 740 35 splice splice NN cord-267475-6f4h3cck 740 36 site site NN cord-267475-6f4h3cck 740 37 . . . cord-267475-6f4h3cck 741 1 6 6 LS cord-267475-6f4h3cck 741 2 . . . cord-267475-6f4h3cck 742 1 Surveys survey NNS cord-267475-6f4h3cck 742 2 and and CC cord-267475-6f4h3cck 742 3 assays assay NNS cord-267475-6f4h3cck 742 4 and and CC cord-267475-6f4h3cck 742 5 problems problem NNS cord-267475-6f4h3cck 742 6 therein therein IN cord-267475-6f4h3cck 742 7 6.1 6.1 CD cord-267475-6f4h3cck 742 8 . . . cord-267475-6f4h3cck 742 9 cDNA cDNA NNP cord-267475-6f4h3cck 742 10 surveys survey NNS cord-267475-6f4h3cck 742 11 Surveys Surveys NNPS cord-267475-6f4h3cck 742 12 of of IN cord-267475-6f4h3cck 742 13 mRNA mRNA NNP cord-267475-6f4h3cck 742 14 / / SYM cord-267475-6f4h3cck 742 15 cDNA cdna NN cord-267475-6f4h3cck 742 16 sequences sequence NNS cord-267475-6f4h3cck 742 17 differ differ VBP cord-267475-6f4h3cck 742 18 in in IN cord-267475-6f4h3cck 742 19 other other JJ cord-267475-6f4h3cck 742 20 details detail NNS cord-267475-6f4h3cck 742 21 , , , cord-267475-6f4h3cck 742 22 but but CC cord-267475-6f4h3cck 742 23 every every DT cord-267475-6f4h3cck 742 24 survey survey NN cord-267475-6f4h3cck 742 25 confirms confirm VBZ cord-267475-6f4h3cck 742 26 the the DT cord-267475-6f4h3cck 742 27 presence presence NN cord-267475-6f4h3cck 742 28 of of IN cord-267475-6f4h3cck 742 29 a a DT cord-267475-6f4h3cck 742 30 purine purine NN cord-267475-6f4h3cck 742 31 in in IN cord-267475-6f4h3cck 742 32 position position NN cord-267475-6f4h3cck 742 33 2 2 CD cord-267475-6f4h3cck 742 34 3 3 CD cord-267475-6f4h3cck 742 35 in in IN cord-267475-6f4h3cck 742 36 most most RBS cord-267475-6f4h3cck 742 37 ( ( -LRB- cord-267475-6f4h3cck 742 38 $ $ $ cord-267475-6f4h3cck 742 39 90 90 CD cord-267475-6f4h3cck 742 40 % % NN cord-267475-6f4h3cck 742 41 ) ) -RRB- cord-267475-6f4h3cck 742 42 vertebrate vertebrate NN cord-267475-6f4h3cck 742 43 mRNAs mRNAs . cord-267475-6f4h3cck 743 1 ( ( -LRB- cord-267475-6f4h3cck 743 2 Kozak Kozak NNP cord-267475-6f4h3cck 743 3 , , , cord-267475-6f4h3cck 743 4 1987a 1987a CD cord-267475-6f4h3cck 743 5 ; ; : cord-267475-6f4h3cck 743 6 Pesole Pesole NNP cord-267475-6f4h3cck 743 7 et et NNP cord-267475-6f4h3cck 743 8 al al NNP cord-267475-6f4h3cck 743 9 . . NNP cord-267475-6f4h3cck 743 10 , , , cord-267475-6f4h3cck 743 11 2000 2000 CD cord-267475-6f4h3cck 743 12 ; ; : cord-267475-6f4h3cck 744 1 Rogozin Rogozin NNP cord-267475-6f4h3cck 744 2 et et NNP cord-267475-6f4h3cck 744 3 al al NNP cord-267475-6f4h3cck 744 4 . . NNP cord-267475-6f4h3cck 744 5 , , , cord-267475-6f4h3cck 744 6 2001 2001 CD cord-267475-6f4h3cck 744 7 ; ; : cord-267475-6f4h3cck 744 8 Sakai Sakai NNP cord-267475-6f4h3cck 744 9 et et NNP cord-267475-6f4h3cck 744 10 al al NNP cord-267475-6f4h3cck 744 11 . . NNP cord-267475-6f4h3cck 744 12 , , , cord-267475-6f4h3cck 744 13 2001 2001 CD cord-267475-6f4h3cck 744 14 ) ) -RRB- cord-267475-6f4h3cck 744 15 . . . cord-267475-6f4h3cck 745 1 The the DT cord-267475-6f4h3cck 745 2 occasional occasional JJ cord-267475-6f4h3cck 745 3 survey survey NN cord-267475-6f4h3cck 745 4 that that WDT cord-267475-6f4h3cck 745 5 purports purport VBZ cord-267475-6f4h3cck 745 6 to to TO cord-267475-6f4h3cck 745 7 challenge challenge VB cord-267475-6f4h3cck 745 8 the the DT cord-267475-6f4h3cck 745 9 context context NN cord-267475-6f4h3cck 745 10 rules rule NNS cord-267475-6f4h3cck 745 11 involves involve VBZ cord-267475-6f4h3cck 745 12 distortions distortion NNS cord-267475-6f4h3cck 745 13 , , , cord-267475-6f4h3cck 745 14 such such JJ cord-267475-6f4h3cck 745 15 as as IN cord-267475-6f4h3cck 745 16 emphasizing emphasize VBG cord-267475-6f4h3cck 745 17 the the DT cord-267475-6f4h3cck 745 18 low low JJ cord-267475-6f4h3cck 745 19 percentage percentage NN cord-267475-6f4h3cck 745 20 of of IN cord-267475-6f4h3cck 745 21 cDNAs cdna NNS cord-267475-6f4h3cck 745 22 that that WDT cord-267475-6f4h3cck 745 23 have have VBP cord-267475-6f4h3cck 745 24 the the DT cord-267475-6f4h3cck 745 25 full full JJ cord-267475-6f4h3cck 745 26 consensus consensus NN cord-267475-6f4h3cck 745 27 sequence sequence NN cord-267475-6f4h3cck 745 28 while while IN cord-267475-6f4h3cck 745 29 ignoring ignore VBG cord-267475-6f4h3cck 745 30 the the DT cord-267475-6f4h3cck 745 31 high high JJ cord-267475-6f4h3cck 745 32 percentage percentage NN cord-267475-6f4h3cck 745 33 of of IN cord-267475-6f4h3cck 745 34 cDNAs cdna NNS cord-267475-6f4h3cck 745 35 that that WDT cord-267475-6f4h3cck 745 36 have have VBP cord-267475-6f4h3cck 745 37 the the DT cord-267475-6f4h3cck 745 38 critical critical JJ cord-267475-6f4h3cck 745 39 purine purine NN cord-267475-6f4h3cck 745 40 in in IN cord-267475-6f4h3cck 745 41 position position NN cord-267475-6f4h3cck 745 42 2 2 CD cord-267475-6f4h3cck 745 43 3 3 CD cord-267475-6f4h3cck 746 1 ( ( -LRB- cord-267475-6f4h3cck 746 2 Peri Peri NNP cord-267475-6f4h3cck 746 3 and and CC cord-267475-6f4h3cck 746 4 Pandey Pandey NNP cord-267475-6f4h3cck 746 5 , , , cord-267475-6f4h3cck 746 6 2001 2001 CD cord-267475-6f4h3cck 746 7 ) ) -RRB- cord-267475-6f4h3cck 746 8 . . . cord-267475-6f4h3cck 747 1 A a DT cord-267475-6f4h3cck 747 2 major major JJ cord-267475-6f4h3cck 747 3 uncertainty uncertainty NN cord-267475-6f4h3cck 747 4 pertaining pertain VBG cord-267475-6f4h3cck 747 5 to to IN cord-267475-6f4h3cck 747 6 all all DT cord-267475-6f4h3cck 747 7 cDNA cdna NN cord-267475-6f4h3cck 747 8 surveys survey NNS cord-267475-6f4h3cck 747 9 concerns concern VBZ cord-267475-6f4h3cck 747 10 the the DT cord-267475-6f4h3cck 747 11 validity validity NN cord-267475-6f4h3cck 747 12 of of IN cord-267475-6f4h3cck 747 13 the the DT cord-267475-6f4h3cck 747 14 database database NN cord-267475-6f4h3cck 747 15 . . . cord-267475-6f4h3cck 748 1 When when WRB cord-267475-6f4h3cck 748 2 I -PRON- PRP cord-267475-6f4h3cck 748 3 re re VBD cord-267475-6f4h3cck 748 4 - - VBD cord-267475-6f4h3cck 748 5 examined examine VBD cord-267475-6f4h3cck 748 6 the the DT cord-267475-6f4h3cck 748 7 entries entry NNS cord-267475-6f4h3cck 748 8 in in IN cord-267475-6f4h3cck 748 9 one one CD cord-267475-6f4h3cck 748 10 study study NN cord-267475-6f4h3cck 748 11 ( ( -LRB- cord-267475-6f4h3cck 748 12 Suzuki Suzuki NNP cord-267475-6f4h3cck 748 13 et et FW cord-267475-6f4h3cck 748 14 al al NNP cord-267475-6f4h3cck 748 15 . . NNP cord-267475-6f4h3cck 748 16 , , , cord-267475-6f4h3cck 748 17 2000 2000 CD cord-267475-6f4h3cck 748 18 ) ) -RRB- cord-267475-6f4h3cck 748 19 , , , cord-267475-6f4h3cck 748 20 I -PRON- PRP cord-267475-6f4h3cck 748 21 found find VBD cord-267475-6f4h3cck 748 22 numerous numerous JJ cord-267475-6f4h3cck 748 23 instances instance NNS cord-267475-6f4h3cck 748 24 in in IN cord-267475-6f4h3cck 748 25 which which WDT cord-267475-6f4h3cck 748 26 the the DT cord-267475-6f4h3cck 748 27 AUG AUG NNP cord-267475-6f4h3cck 748 28 START START NNP cord-267475-6f4h3cck 748 29 codon codon NN cord-267475-6f4h3cck 748 30 had have VBD cord-267475-6f4h3cck 748 31 been be VBN cord-267475-6f4h3cck 748 32 misidentified misidentifie VBN cord-267475-6f4h3cck 748 33 ; ; : cord-267475-6f4h3cck 748 34 the the DT cord-267475-6f4h3cck 748 35 corrected correct VBN cord-267475-6f4h3cck 748 36 start start NN cord-267475-6f4h3cck 748 37 sites site NNS cord-267475-6f4h3cck 748 38 adhered adhere VBD cord-267475-6f4h3cck 748 39 more more RBR cord-267475-6f4h3cck 748 40 closely closely RB cord-267475-6f4h3cck 748 41 to to IN cord-267475-6f4h3cck 748 42 the the DT cord-267475-6f4h3cck 748 43 consensus consensus NN cord-267475-6f4h3cck 748 44 motif motif NN cord-267475-6f4h3cck 748 45 ( ( -LRB- cord-267475-6f4h3cck 748 46 Kozak Kozak NNP cord-267475-6f4h3cck 748 47 , , , cord-267475-6f4h3cck 748 48 2000 2000 CD cord-267475-6f4h3cck 748 49 ) ) -RRB- cord-267475-6f4h3cck 748 50 . . . cord-267475-6f4h3cck 749 1 Some some DT cord-267475-6f4h3cck 749 2 authors author NNS cord-267475-6f4h3cck 749 3 pre pre VBP cord-267475-6f4h3cck 749 4 - - NNS cord-267475-6f4h3cck 749 5 emptively emptively RB cord-267475-6f4h3cck 749 6 defend defend VB cord-267475-6f4h3cck 749 7 their -PRON- PRP$ cord-267475-6f4h3cck 749 8 conclusions conclusion NNS cord-267475-6f4h3cck 749 9 on on IN cord-267475-6f4h3cck 749 10 the the DT cord-267475-6f4h3cck 749 11 grounds ground NNS cord-267475-6f4h3cck 749 12 that that IN cord-267475-6f4h3cck 749 13 the the DT cord-267475-6f4h3cck 749 14 ( ( -LRB- cord-267475-6f4h3cck 749 15 unidentified unidentified JJ cord-267475-6f4h3cck 749 16 ) ) -RRB- cord-267475-6f4h3cck 749 17 cDNA cdna NN cord-267475-6f4h3cck 749 18 sequences sequence NNS cord-267475-6f4h3cck 749 19 used use VBN cord-267475-6f4h3cck 749 20 for for IN cord-267475-6f4h3cck 749 21 their -PRON- PRP$ cord-267475-6f4h3cck 749 22 analysis analysis NN cord-267475-6f4h3cck 749 23 derive derive VBP cord-267475-6f4h3cck 749 24 from from IN cord-267475-6f4h3cck 749 25 RefSeq RefSeq NNP cord-267475-6f4h3cck 749 26 , , , cord-267475-6f4h3cck 749 27 which which WDT cord-267475-6f4h3cck 749 28 is be VBZ cord-267475-6f4h3cck 749 29 a a DT cord-267475-6f4h3cck 749 30 curated curated JJ cord-267475-6f4h3cck 749 31 database database NN cord-267475-6f4h3cck 749 32 ( ( -LRB- cord-267475-6f4h3cck 749 33 Pruitt Pruitt NNP cord-267475-6f4h3cck 749 34 et et NNP cord-267475-6f4h3cck 749 35 al al NNP cord-267475-6f4h3cck 749 36 . . NNP cord-267475-6f4h3cck 749 37 , , , cord-267475-6f4h3cck 749 38 2000 2000 CD cord-267475-6f4h3cck 749 39 ) ) -RRB- cord-267475-6f4h3cck 749 40 . . . cord-267475-6f4h3cck 750 1 But but CC cord-267475-6f4h3cck 750 2 the the DT cord-267475-6f4h3cck 750 3 entries entry NNS cord-267475-6f4h3cck 750 4 in in IN cord-267475-6f4h3cck 750 5 RefSeq RefSeq NNP cord-267475-6f4h3cck 750 6 are be VBP cord-267475-6f4h3cck 750 7 not not RB cord-267475-6f4h3cck 750 8 without without IN cord-267475-6f4h3cck 750 9 errors error NNS cord-267475-6f4h3cck 750 10 , , , cord-267475-6f4h3cck 750 11 some some DT cord-267475-6f4h3cck 750 12 of of IN cord-267475-6f4h3cck 750 13 which which WDT cord-267475-6f4h3cck 750 14 -e.g -e.g VBZ cord-267475-6f4h3cck 750 15 . . . cord-267475-6f4h3cck 751 1 misidentified misidentifie VBN cord-267475-6f4h3cck 751 2 start start NN cord-267475-6f4h3cck 751 3 codons codon NNS cord-267475-6f4h3cck 751 4 , , , cord-267475-6f4h3cck 751 5 mistaken mistaken JJ cord-267475-6f4h3cck 751 6 claims claim NNS cord-267475-6f4h3cck 751 7 of of IN cord-267475-6f4h3cck 751 8 upstream upstream JJ cord-267475-6f4h3cck 751 9 AUG AUG NNP cord-267475-6f4h3cck 751 10 codons codon NNS cord-267475-6f4h3cck 751 11 -can -can -LRB- cord-267475-6f4h3cck 751 12 be be VB cord-267475-6f4h3cck 751 13 traced trace VBN cord-267475-6f4h3cck 751 14 by by IN cord-267475-6f4h3cck 751 15 comparing compare VBG cord-267475-6f4h3cck 751 16 curated curate VBN cord-267475-6f4h3cck 751 17 GenBank GenBank NNP cord-267475-6f4h3cck 751 18 entries entry NNS cord-267475-6f4h3cck 751 19 NM_005493 NM_005493 NNP cord-267475-6f4h3cck 751 20 , , , cord-267475-6f4h3cck 751 21 NM_005502 NM_005502 NNP cord-267475-6f4h3cck 751 22 , , , cord-267475-6f4h3cck 751 23 NM_000282 NM_000282 NNP cord-267475-6f4h3cck 751 24 and and CC cord-267475-6f4h3cck 751 25 NM_003605 NM_003605 NNP cord-267475-6f4h3cck 751 26 with with IN cord-267475-6f4h3cck 751 27 results result NNS cord-267475-6f4h3cck 751 28 published publish VBN cord-267475-6f4h3cck 751 29 else else RB cord-267475-6f4h3cck 751 30 - - , cord-267475-6f4h3cck 751 31 where where WRB cord-267475-6f4h3cck 751 32 ( ( -LRB- cord-267475-6f4h3cck 751 33 Campeau Campeau NNP cord-267475-6f4h3cck 751 34 et et NNP cord-267475-6f4h3cck 751 35 al al NNP cord-267475-6f4h3cck 751 36 . . NNP cord-267475-6f4h3cck 751 37 , , , cord-267475-6f4h3cck 751 38 2001 2001 CD cord-267475-6f4h3cck 751 39 ; ; : cord-267475-6f4h3cck 752 1 Nishitani Nishitani NNP cord-267475-6f4h3cck 752 2 et et NNP cord-267475-6f4h3cck 752 3 al al NNP cord-267475-6f4h3cck 752 4 . . NNP cord-267475-6f4h3cck 752 5 , , , cord-267475-6f4h3cck 752 6 2001 2001 CD cord-267475-6f4h3cck 752 7 ; ; : cord-267475-6f4h3cck 752 8 Nolte Nolte NNP cord-267475-6f4h3cck 752 9 and and CC cord-267475-6f4h3cck 752 10 Müller Müller NNP cord-267475-6f4h3cck 752 11 , , , cord-267475-6f4h3cck 752 12 2002 2002 CD cord-267475-6f4h3cck 753 1 ; ; : cord-267475-6f4h3cck 753 2 Santamarina Santamarina NNP cord-267475-6f4h3cck 753 3 - - HYPH cord-267475-6f4h3cck 753 4 Fojo Fojo NNP cord-267475-6f4h3cck 753 5 et et NNP cord-267475-6f4h3cck 753 6 al al NNP cord-267475-6f4h3cck 753 7 . . NNP cord-267475-6f4h3cck 753 8 , , , cord-267475-6f4h3cck 753 9 2000 2000 CD cord-267475-6f4h3cck 753 10 ) ) -RRB- cord-267475-6f4h3cck 753 11 . . . cord-267475-6f4h3cck 754 1 Some some DT cord-267475-6f4h3cck 754 2 cDNA cdna NN cord-267475-6f4h3cck 754 3 surveys survey NNS cord-267475-6f4h3cck 754 4 use use VBP cord-267475-6f4h3cck 754 5 misleading mislead VBG cord-267475-6f4h3cck 754 6 terminology terminology NN cord-267475-6f4h3cck 754 7 , , , cord-267475-6f4h3cck 754 8 e.g. e.g. RB cord-267475-6f4h3cck 754 9 referring refer VBG cord-267475-6f4h3cck 754 10 to to IN cord-267475-6f4h3cck 754 11 upstream upstream JJ cord-267475-6f4h3cck 754 12 AUG AUG NNP cord-267475-6f4h3cck 754 13 codons codon NNS cord-267475-6f4h3cck 754 14 as as IN cord-267475-6f4h3cck 754 15 ' ' `` cord-267475-6f4h3cck 754 16 unused unused JJ cord-267475-6f4h3cck 754 17 ' ' '' cord-267475-6f4h3cck 754 18 ( ( -LRB- cord-267475-6f4h3cck 754 19 Peri Peri NNP cord-267475-6f4h3cck 754 20 and and CC cord-267475-6f4h3cck 754 21 Pandey Pandey NNP cord-267475-6f4h3cck 754 22 , , , cord-267475-6f4h3cck 754 23 2001 2001 CD cord-267475-6f4h3cck 754 24 ) ) -RRB- cord-267475-6f4h3cck 754 25 . . . cord-267475-6f4h3cck 755 1 Given give VBN cord-267475-6f4h3cck 755 2 that that DT cord-267475-6f4h3cck 755 3 upstream upstream JJ cord-267475-6f4h3cck 755 4 AUG AUG NNP cord-267475-6f4h3cck 755 5 codons codon NNS cord-267475-6f4h3cck 755 6 are be VBP cord-267475-6f4h3cck 755 7 used use VBN cord-267475-6f4h3cck 755 8 , , , cord-267475-6f4h3cck 755 9 as as IN cord-267475-6f4h3cck 755 10 proved prove VBN cord-267475-6f4h3cck 755 11 by by IN cord-267475-6f4h3cck 755 12 detecting detect VBG cord-267475-6f4h3cck 755 13 the the DT cord-267475-6f4h3cck 755 14 encoded encoded JJ cord-267475-6f4h3cck 755 15 peptide peptide NN cord-267475-6f4h3cck 755 16 or or CC cord-267475-6f4h3cck 755 17 by by IN cord-267475-6f4h3cck 755 18 fusing fuse VBG cord-267475-6f4h3cck 755 19 the the DT cord-267475-6f4h3cck 755 20 upORF uporf JJ cord-267475-6f4h3cck 755 21 to to IN cord-267475-6f4h3cck 755 22 a a DT cord-267475-6f4h3cck 755 23 reporter reporter NN cord-267475-6f4h3cck 755 24 gene gene NN cord-267475-6f4h3cck 755 25 , , , cord-267475-6f4h3cck 755 26 it -PRON- PRP cord-267475-6f4h3cck 755 27 is be VBZ cord-267475-6f4h3cck 755 28 not not RB cord-267475-6f4h3cck 755 29 anomalous anomalous JJ cord-267475-6f4h3cck 755 30 to to TO cord-267475-6f4h3cck 755 31 find find VB cord-267475-6f4h3cck 755 32 a a DT cord-267475-6f4h3cck 755 33 good good JJ cord-267475-6f4h3cck 755 34 context context NN cord-267475-6f4h3cck 755 35 around around IN cord-267475-6f4h3cck 755 36 some some DT cord-267475-6f4h3cck 755 37 upstream upstream JJ cord-267475-6f4h3cck 755 38 AUG AUG NNP cord-267475-6f4h3cck 755 39 codons codon NNS cord-267475-6f4h3cck 755 40 . . . cord-267475-6f4h3cck 756 1 All all DT cord-267475-6f4h3cck 756 2 surveys survey NNS cord-267475-6f4h3cck 756 3 tend tend VBP cord-267475-6f4h3cck 756 4 to to TO cord-267475-6f4h3cck 756 5 overestimate overestimate VB cord-267475-6f4h3cck 756 6 the the DT cord-267475-6f4h3cck 756 7 incidence incidence NN cord-267475-6f4h3cck 756 8 of of IN cord-267475-6f4h3cck 756 9 upstream upstream JJ cord-267475-6f4h3cck 756 10 AUGs aug NNS cord-267475-6f4h3cck 756 11 by by IN cord-267475-6f4h3cck 756 12 scoring score VBG cord-267475-6f4h3cck 756 13 only only RB cord-267475-6f4h3cck 756 14 the the DT cord-267475-6f4h3cck 756 15 longest long JJS cord-267475-6f4h3cck 756 16 cDNA cdna NN cord-267475-6f4h3cck 756 17 isoform isoform NN cord-267475-6f4h3cck 756 18 , , , cord-267475-6f4h3cck 756 19 ignoring ignore VBG cord-267475-6f4h3cck 756 20 the the DT cord-267475-6f4h3cck 756 21 existence existence NN cord-267475-6f4h3cck 756 22 of of IN cord-267475-6f4h3cck 756 23 alternative alternative JJ cord-267475-6f4h3cck 756 24 transcripts transcript NNS cord-267475-6f4h3cck 756 25 that that WDT cord-267475-6f4h3cck 756 26 have have VBP cord-267475-6f4h3cck 756 27 shorter short JJR cord-267475-6f4h3cck 756 28 , , , cord-267475-6f4h3cck 756 29 unencumbered unencumbered JJ cord-267475-6f4h3cck 756 30 5 5 CD cord-267475-6f4h3cck 756 31 0 0 CD cord-267475-6f4h3cck 756 32 UTRs utr NNS cord-267475-6f4h3cck 756 33 ( ( -LRB- cord-267475-6f4h3cck 756 34 Section section NN cord-267475-6f4h3cck 756 35 4.2 4.2 CD cord-267475-6f4h3cck 756 36 ) ) -RRB- cord-267475-6f4h3cck 756 37 . . . cord-267475-6f4h3cck 757 1 The the DT cord-267475-6f4h3cck 757 2 significance significance NN cord-267475-6f4h3cck 757 3 of of IN cord-267475-6f4h3cck 757 4 upstream upstream JJ cord-267475-6f4h3cck 757 5 AUG AUG NNP cord-267475-6f4h3cck 757 6 codons codon NNS cord-267475-6f4h3cck 757 7 also also RB cord-267475-6f4h3cck 757 8 tends tend VBZ cord-267475-6f4h3cck 757 9 to to TO cord-267475-6f4h3cck 757 10 be be VB cord-267475-6f4h3cck 757 11 misstated misstate VBN cord-267475-6f4h3cck 757 12 : : : cord-267475-6f4h3cck 757 13 the the DT cord-267475-6f4h3cck 757 14 presence presence NN cord-267475-6f4h3cck 757 15 of of IN cord-267475-6f4h3cck 757 16 small small JJ cord-267475-6f4h3cck 757 17 upORFs uporfs NN cord-267475-6f4h3cck 757 18 in in IN cord-267475-6f4h3cck 757 19 vertebrate vertebrate NN cord-267475-6f4h3cck 757 20 mRNAs mrnas CD cord-267475-6f4h3cck 757 21 which which WDT cord-267475-6f4h3cck 757 22 are be VBP cord-267475-6f4h3cck 757 23 thereby thereby RB cord-267475-6f4h3cck 757 24 translated translate VBN cord-267475-6f4h3cck 757 25 inefficiently inefficiently RB cord-267475-6f4h3cck 757 26 ( ( -LRB- cord-267475-6f4h3cck 757 27 see see VB cord-267475-6f4h3cck 757 28 the the DT cord-267475-6f4h3cck 757 29 foregoing forego VBG cord-267475-6f4h3cck 757 30 discussion discussion NN cord-267475-6f4h3cck 757 31 of of IN cord-267475-6f4h3cck 757 32 TPO TPO NNP cord-267475-6f4h3cck 757 33 , , , cord-267475-6f4h3cck 757 34 oncogenes oncogene NNS cord-267475-6f4h3cck 757 35 , , , cord-267475-6f4h3cck 757 36 etc etc FW cord-267475-6f4h3cck 757 37 . . . cord-267475-6f4h3cck 757 38 ) ) -RRB- cord-267475-6f4h3cck 758 1 constitutes constitute VBZ cord-267475-6f4h3cck 758 2 evidence evidence NN cord-267475-6f4h3cck 758 3 for for IN cord-267475-6f4h3cck 758 4 , , , cord-267475-6f4h3cck 758 5 rather rather RB cord-267475-6f4h3cck 758 6 than than IN cord-267475-6f4h3cck 758 7 against against IN cord-267475-6f4h3cck 758 8 , , , cord-267475-6f4h3cck 758 9 the the DT cord-267475-6f4h3cck 758 10 scanning scanning NN cord-267475-6f4h3cck 758 11 model model NN cord-267475-6f4h3cck 758 12 . . . cord-267475-6f4h3cck 759 1 The the DT cord-267475-6f4h3cck 759 2 first first JJ cord-267475-6f4h3cck 759 3 - - HYPH cord-267475-6f4h3cck 759 4 AUG aug NN cord-267475-6f4h3cck 759 5 rule rule NN cord-267475-6f4h3cck 759 6 , , , cord-267475-6f4h3cck 759 7 which which WDT cord-267475-6f4h3cck 759 8 I -PRON- PRP cord-267475-6f4h3cck 759 9 cite cite VBP cord-267475-6f4h3cck 759 10 as as IN cord-267475-6f4h3cck 759 11 evidence evidence NN cord-267475-6f4h3cck 759 12 for for IN cord-267475-6f4h3cck 759 13 the the DT cord-267475-6f4h3cck 759 14 scanning scanning NN cord-267475-6f4h3cck 759 15 mechanism mechanism NN cord-267475-6f4h3cck 759 16 , , , cord-267475-6f4h3cck 759 17 derives derive VBZ cord-267475-6f4h3cck 759 18 not not RB cord-267475-6f4h3cck 759 19 from from IN cord-267475-6f4h3cck 759 20 statistical statistical JJ cord-267475-6f4h3cck 759 21 analysis analysis NN cord-267475-6f4h3cck 759 22 of of IN cord-267475-6f4h3cck 759 23 cDNA cdna NN cord-267475-6f4h3cck 759 24 sequences sequence NNS cord-267475-6f4h3cck 759 25 but but CC cord-267475-6f4h3cck 759 26 from from IN cord-267475-6f4h3cck 759 27 the the DT cord-267475-6f4h3cck 759 28 experimentally experimentally RB cord-267475-6f4h3cck 759 29 observed observe VBN cord-267475-6f4h3cck 759 30 fact fact NN cord-267475-6f4h3cck 759 31 ( ( -LRB- cord-267475-6f4h3cck 759 32 Section section NN cord-267475-6f4h3cck 759 33 2.2 2.2 CD cord-267475-6f4h3cck 759 34 ) ) -RRB- cord-267475-6f4h3cck 759 35 that that IN cord-267475-6f4h3cck 759 36 translation translation NN cord-267475-6f4h3cck 759 37 shifts shift VBZ cord-267475-6f4h3cck 759 38 predictably predictably RB cord-267475-6f4h3cck 759 39 upstream upstream VBP cord-267475-6f4h3cck 759 40 or or CC cord-267475-6f4h3cck 759 41 downstream downstream JJ cord-267475-6f4h3cck 759 42 when when WRB cord-267475-6f4h3cck 759 43 an an DT cord-267475-6f4h3cck 759 44 AUG AUG NNP cord-267475-6f4h3cck 759 45 codon codon NN cord-267475-6f4h3cck 759 46 is be VBZ cord-267475-6f4h3cck 759 47 added add VBN cord-267475-6f4h3cck 759 48 or or CC cord-267475-6f4h3cck 759 49 removed remove VBN cord-267475-6f4h3cck 759 50 . . . cord-267475-6f4h3cck 760 1 In in IN cord-267475-6f4h3cck 760 2 short short JJ cord-267475-6f4h3cck 760 3 , , , cord-267475-6f4h3cck 760 4 it -PRON- PRP cord-267475-6f4h3cck 760 5 makes make VBZ cord-267475-6f4h3cck 760 6 more more JJR cord-267475-6f4h3cck 760 7 sense sense NN cord-267475-6f4h3cck 760 8 to to TO cord-267475-6f4h3cck 760 9 use use VB cord-267475-6f4h3cck 760 10 the the DT cord-267475-6f4h3cck 760 11 scanning scanning NN cord-267475-6f4h3cck 760 12 / / SYM cord-267475-6f4h3cck 760 13 context context NN cord-267475-6f4h3cck 760 14 rules rule NNS cord-267475-6f4h3cck 760 15 to to TO cord-267475-6f4h3cck 760 16 evaluate evaluate VB cord-267475-6f4h3cck 760 17 cDNA cdna NN cord-267475-6f4h3cck 760 18 sequences sequence NNS cord-267475-6f4h3cck 760 19 ( ( -LRB- cord-267475-6f4h3cck 760 20 Hatzigeorgiou Hatzigeorgiou NNP cord-267475-6f4h3cck 760 21 , , , cord-267475-6f4h3cck 760 22 2002 2002 CD cord-267475-6f4h3cck 760 23 ) ) -RRB- cord-267475-6f4h3cck 760 24 than than IN cord-267475-6f4h3cck 760 25 to to TO cord-267475-6f4h3cck 760 26 attempt attempt VB cord-267475-6f4h3cck 760 27 the the DT cord-267475-6f4h3cck 760 28 reverse reverse NN cord-267475-6f4h3cck 760 29 . . . cord-267475-6f4h3cck 761 1 While while IN cord-267475-6f4h3cck 761 2 conclusions conclusion NNS cord-267475-6f4h3cck 761 3 about about IN cord-267475-6f4h3cck 761 4 translation translation NN cord-267475-6f4h3cck 761 5 derived derive VBN cord-267475-6f4h3cck 761 6 from from IN cord-267475-6f4h3cck 761 7 experimental experimental JJ cord-267475-6f4h3cck 761 8 studies study NNS cord-267475-6f4h3cck 761 9 are be VBP cord-267475-6f4h3cck 761 10 arguably arguably RB cord-267475-6f4h3cck 761 11 more more RBR cord-267475-6f4h3cck 761 12 meaningful meaningful JJ cord-267475-6f4h3cck 761 13 than than IN cord-267475-6f4h3cck 761 14 those those DT cord-267475-6f4h3cck 761 15 derived derive VBN cord-267475-6f4h3cck 761 16 from from IN cord-267475-6f4h3cck 761 17 statistics statistic NNS cord-267475-6f4h3cck 761 18 , , , cord-267475-6f4h3cck 761 19 the the DT cord-267475-6f4h3cck 761 20 interpretation interpretation NN cord-267475-6f4h3cck 761 21 of of IN cord-267475-6f4h3cck 761 22 experimental experimental JJ cord-267475-6f4h3cck 761 23 results result NNS cord-267475-6f4h3cck 761 24 can can MD cord-267475-6f4h3cck 761 25 be be VB cord-267475-6f4h3cck 761 26 complicated complicated JJ cord-267475-6f4h3cck 761 27 . . . cord-267475-6f4h3cck 762 1 In in IN cord-267475-6f4h3cck 762 2 vivo vivo NN cord-267475-6f4h3cck 762 3 assays assay NNS cord-267475-6f4h3cck 762 4 avoid avoid VBP cord-267475-6f4h3cck 762 5 the the DT cord-267475-6f4h3cck 762 6 problem problem NN cord-267475-6f4h3cck 762 7 of of IN cord-267475-6f4h3cck 762 8 reaction reaction NN cord-267475-6f4h3cck 762 9 - - HYPH cord-267475-6f4h3cck 762 10 conditions condition NNS cord-267475-6f4h3cck 762 11 - - HYPH cord-267475-6f4h3cck 762 12 dictating dictate VBG cord-267475-6f4h3cck 762 13 - - HYPH cord-267475-6f4h3cck 762 14 the the DT cord-267475-6f4h3cck 762 15 - - HYPH cord-267475-6f4h3cck 762 16 outcome outcome NN cord-267475-6f4h3cck 762 17 ( ( -LRB- cord-267475-6f4h3cck 762 18 see see VB cord-267475-6f4h3cck 762 19 next next JJ cord-267475-6f4h3cck 762 20 paragraph paragraph NN cord-267475-6f4h3cck 762 21 ) ) -RRB- cord-267475-6f4h3cck 762 22 , , , cord-267475-6f4h3cck 762 23 but but CC cord-267475-6f4h3cck 762 24 there there EX cord-267475-6f4h3cck 762 25 are be VBP cord-267475-6f4h3cck 762 26 other other JJ cord-267475-6f4h3cck 762 27 potential potential JJ cord-267475-6f4h3cck 762 28 traps trap NNS cord-267475-6f4h3cck 762 29 . . . cord-267475-6f4h3cck 763 1 The the DT cord-267475-6f4h3cck 763 2 usually usually RB cord-267475-6f4h3cck 763 3 - - HYPH cord-267475-6f4h3cck 763 4 valid valid JJ cord-267475-6f4h3cck 763 5 assumption assumption NN cord-267475-6f4h3cck 763 6 that that WDT cord-267475-6f4h3cck 763 7 polysomal polysomal NNP cord-267475-6f4h3cck 763 8 association association NNP cord-267475-6f4h3cck 763 9 identifies identify VBZ cord-267475-6f4h3cck 763 10 actively actively RB cord-267475-6f4h3cck 763 11 translated translate VBN cord-267475-6f4h3cck 763 12 mRNAs mrnas WDT cord-267475-6f4h3cck 763 13 is be VBZ cord-267475-6f4h3cck 763 14 called call VBN cord-267475-6f4h3cck 763 15 into into IN cord-267475-6f4h3cck 763 16 question question NN cord-267475-6f4h3cck 763 17 by by IN cord-267475-6f4h3cck 763 18 the the DT cord-267475-6f4h3cck 763 19 recent recent JJ cord-267475-6f4h3cck 763 20 discovery discovery NN cord-267475-6f4h3cck 763 21 of of IN cord-267475-6f4h3cck 763 22 mRNAs mrnas CD cord-267475-6f4h3cck 763 23 trapped trap VBN cord-267475-6f4h3cck 763 24 on on IN cord-267475-6f4h3cck 763 25 large large JJ cord-267475-6f4h3cck 763 26 polysomes polysome NNS cord-267475-6f4h3cck 763 27 from from IN cord-267475-6f4h3cck 763 28 which which WDT cord-267475-6f4h3cck 763 29 there there EX cord-267475-6f4h3cck 763 30 is be VBZ cord-267475-6f4h3cck 763 31 no no DT cord-267475-6f4h3cck 763 32 polypeptide polypeptide NN cord-267475-6f4h3cck 763 33 production production NN cord-267475-6f4h3cck 764 1 ( ( -LRB- cord-267475-6f4h3cck 764 2 Rüegsegger Rüegsegger NNP cord-267475-6f4h3cck 764 3 et et FW cord-267475-6f4h3cck 764 4 al al NNP cord-267475-6f4h3cck 764 5 . . NNP cord-267475-6f4h3cck 764 6 , , , cord-267475-6f4h3cck 764 7 2001 2001 CD cord-267475-6f4h3cck 764 8 ) ) -RRB- cord-267475-6f4h3cck 764 9 . . . cord-267475-6f4h3cck 765 1 The the DT cord-267475-6f4h3cck 765 2 major major JJ cord-267475-6f4h3cck 765 3 problem problem NN cord-267475-6f4h3cck 765 4 when when WRB cord-267475-6f4h3cck 765 5 translation translation NN cord-267475-6f4h3cck 765 6 is be VBZ cord-267475-6f4h3cck 765 7 studied study VBN cord-267475-6f4h3cck 765 8 in in IN cord-267475-6f4h3cck 765 9 vivo vivo NN cord-267475-6f4h3cck 765 10 is be VBZ cord-267475-6f4h3cck 765 11 uncertainty uncertainty NN cord-267475-6f4h3cck 765 12 about about IN cord-267475-6f4h3cck 765 13 the the DT cord-267475-6f4h3cck 765 14 structure structure NN cord-267475-6f4h3cck 765 15 of of IN cord-267475-6f4h3cck 765 16 the the DT cord-267475-6f4h3cck 765 17 mRNA mrna NN cord-267475-6f4h3cck 765 18 . . . cord-267475-6f4h3cck 766 1 For for IN cord-267475-6f4h3cck 766 2 example example NN cord-267475-6f4h3cck 766 3 , , , cord-267475-6f4h3cck 766 4 a a DT cord-267475-6f4h3cck 766 5 claim claim NN cord-267475-6f4h3cck 766 6 that that IN cord-267475-6f4h3cck 766 7 IRES IRES NNP cord-267475-6f4h3cck 766 8 - - HYPH cord-267475-6f4h3cck 766 9 mediated mediate VBN cord-267475-6f4h3cck 766 10 translation translation NN cord-267475-6f4h3cck 766 11 is be VBZ cord-267475-6f4h3cck 766 12 developmentally developmentally RB cord-267475-6f4h3cck 766 13 regulated regulate VBN cord-267475-6f4h3cck 766 14 ( ( -LRB- cord-267475-6f4h3cck 766 15 Créancier Créancier NNP cord-267475-6f4h3cck 766 16 et et NNP cord-267475-6f4h3cck 766 17 al al NNP cord-267475-6f4h3cck 766 18 . . NNP cord-267475-6f4h3cck 766 19 , , , cord-267475-6f4h3cck 766 20 2000 2000 CD cord-267475-6f4h3cck 767 1 ( ( -LRB- cord-267475-6f4h3cck 767 2 Créancier Créancier NNP cord-267475-6f4h3cck 767 3 et et FW cord-267475-6f4h3cck 767 4 al al NNP cord-267475-6f4h3cck 767 5 . . . cord-267475-6f4h3cck 768 1 , , , cord-267475-6f4h3cck 768 2 , , , cord-267475-6f4h3cck 768 3 2001 2001 CD cord-267475-6f4h3cck 768 4 is be VBZ cord-267475-6f4h3cck 768 5 premature premature JJ cord-267475-6f4h3cck 768 6 , , , cord-267475-6f4h3cck 768 7 inasmuch inasmuch IN cord-267475-6f4h3cck 768 8 as as IN cord-267475-6f4h3cck 768 9 those those DT cord-267475-6f4h3cck 768 10 studies study NNS cord-267475-6f4h3cck 768 11 monitored monitor VBD cord-267475-6f4h3cck 768 12 the the DT cord-267475-6f4h3cck 768 13 amount amount NN cord-267475-6f4h3cck 768 14 but but CC cord-267475-6f4h3cck 768 15 not not RB cord-267475-6f4h3cck 768 16 the the DT cord-267475-6f4h3cck 768 17 form form NN cord-267475-6f4h3cck 768 18 of of IN cord-267475-6f4h3cck 768 19 mRNA mrna NN cord-267475-6f4h3cck 768 20 . . . cord-267475-6f4h3cck 769 1 When when WRB cord-267475-6f4h3cck 769 2 mRNA mRNA NNP cord-267475-6f4h3cck 769 3 structure structure NN cord-267475-6f4h3cck 769 4 is be VBZ cord-267475-6f4h3cck 769 5 examined examine VBN cord-267475-6f4h3cck 769 6 , , , cord-267475-6f4h3cck 769 7 the the DT cord-267475-6f4h3cck 769 8 developmentally developmentally RB cord-267475-6f4h3cck 769 9 regulated regulated JJ cord-267475-6f4h3cck 769 10 expression expression NN cord-267475-6f4h3cck 769 11 might may MD cord-267475-6f4h3cck 769 12 be be VB cord-267475-6f4h3cck 769 13 found find VBN cord-267475-6f4h3cck 769 14 to to TO cord-267475-6f4h3cck 769 15 reflect reflect VB cord-267475-6f4h3cck 769 16 activation activation NN cord-267475-6f4h3cck 769 17 of of IN cord-267475-6f4h3cck 769 18 an an DT cord-267475-6f4h3cck 769 19 internal internal JJ cord-267475-6f4h3cck 769 20 promoter promoter NN cord-267475-6f4h3cck 769 21 rather rather RB cord-267475-6f4h3cck 769 22 than than IN cord-267475-6f4h3cck 769 23 activation activation NN cord-267475-6f4h3cck 769 24 of of IN cord-267475-6f4h3cck 769 25 an an DT cord-267475-6f4h3cck 769 26 IRES IRES NNP cord-267475-6f4h3cck 769 27 . . . cord-267475-6f4h3cck 770 1 Other other JJ cord-267475-6f4h3cck 770 2 studies study NNS cord-267475-6f4h3cck 770 3 wherein wherein VBZ cord-267475-6f4h3cck 770 4 translation translation NN cord-267475-6f4h3cck 770 5 of of IN cord-267475-6f4h3cck 770 6 an an DT cord-267475-6f4h3cck 770 7 encumbered encumbered JJ cord-267475-6f4h3cck 770 8 leader leader NN cord-267475-6f4h3cck 770 9 sequence sequence NN cord-267475-6f4h3cck 770 10 appears appear VBZ cord-267475-6f4h3cck 770 11 to to TO cord-267475-6f4h3cck 770 12 improve improve VB cord-267475-6f4h3cck 770 13 under under IN cord-267475-6f4h3cck 770 14 certain certain JJ cord-267475-6f4h3cck 770 15 conditions condition NNS cord-267475-6f4h3cck 770 16 or or CC cord-267475-6f4h3cck 770 17 in in IN cord-267475-6f4h3cck 770 18 certain certain JJ cord-267475-6f4h3cck 770 19 cell cell NN cord-267475-6f4h3cck 770 20 types type NNS cord-267475-6f4h3cck 770 21 require require VBP cord-267475-6f4h3cck 770 22 better well JJR cord-267475-6f4h3cck 770 23 analyses analysis NNS cord-267475-6f4h3cck 770 24 to to TO cord-267475-6f4h3cck 770 25 rule rule VB cord-267475-6f4h3cck 770 26 out out RP cord-267475-6f4h3cck 770 27 a a DT cord-267475-6f4h3cck 770 28 possible possible JJ cord-267475-6f4h3cck 770 29 change change NN cord-267475-6f4h3cck 770 30 in in IN cord-267475-6f4h3cck 770 31 structure structure NN cord-267475-6f4h3cck 770 32 of of IN cord-267475-6f4h3cck 770 33 the the DT cord-267475-6f4h3cck 770 34 5 5 CD cord-267475-6f4h3cck 770 35 0 0 CD cord-267475-6f4h3cck 770 36 UTR UTR NNP cord-267475-6f4h3cck 770 37 ( ( -LRB- cord-267475-6f4h3cck 770 38 Bernstein Bernstein NNP cord-267475-6f4h3cck 770 39 et et NNP cord-267475-6f4h3cck 770 40 al al NNP cord-267475-6f4h3cck 770 41 . . NNP cord-267475-6f4h3cck 770 42 , , , cord-267475-6f4h3cck 770 43 1995 1995 CD cord-267475-6f4h3cck 770 44 ; ; : cord-267475-6f4h3cck 770 45 Child Child NNP cord-267475-6f4h3cck 770 46 et et NNP cord-267475-6f4h3cck 770 47 al al NNP cord-267475-6f4h3cck 770 48 . . NNP cord-267475-6f4h3cck 770 49 , , , cord-267475-6f4h3cck 770 50 1999b 1999b CD cord-267475-6f4h3cck 770 51 ; ; : cord-267475-6f4h3cck 770 52 Li Li NNP cord-267475-6f4h3cck 770 53 et et NNP cord-267475-6f4h3cck 770 54 al al NNP cord-267475-6f4h3cck 770 55 . . NNP cord-267475-6f4h3cck 770 56 , , , cord-267475-6f4h3cck 770 57 2001 2001 CD cord-267475-6f4h3cck 770 58 ; ; : cord-267475-6f4h3cck 770 59 Zimmer Zimmer NNP cord-267475-6f4h3cck 770 60 et et NNP cord-267475-6f4h3cck 770 61 al al NNP cord-267475-6f4h3cck 770 62 . . NNP cord-267475-6f4h3cck 770 63 , , , cord-267475-6f4h3cck 770 64 1994 1994 CD cord-267475-6f4h3cck 770 65 ) ) -RRB- cord-267475-6f4h3cck 770 66 . . . cord-267475-6f4h3cck 771 1 Some some DT cord-267475-6f4h3cck 771 2 useful useful JJ cord-267475-6f4h3cck 771 3 hints hint NNS cord-267475-6f4h3cck 771 4 may may MD cord-267475-6f4h3cck 771 5 be be VB cord-267475-6f4h3cck 771 6 found find VBN cord-267475-6f4h3cck 771 7 in in IN cord-267475-6f4h3cck 771 8 reports report NNS cord-267475-6f4h3cck 771 9 that that WDT cord-267475-6f4h3cck 771 10 describe describe VBP cord-267475-6f4h3cck 771 11 the the DT cord-267475-6f4h3cck 771 12 belated belated JJ cord-267475-6f4h3cck 771 13 discovery discovery NN cord-267475-6f4h3cck 771 14 of of IN cord-267475-6f4h3cck 771 15 alternative alternative JJ cord-267475-6f4h3cck 771 16 forms form NNS cord-267475-6f4h3cck 771 17 of of IN cord-267475-6f4h3cck 771 18 mRNA mrna NN cord-267475-6f4h3cck 771 19 that that WDT cord-267475-6f4h3cck 771 20 were be VBD cord-267475-6f4h3cck 771 21 missed miss VBN cord-267475-6f4h3cck 771 22 the the DT cord-267475-6f4h3cck 771 23 first first JJ cord-267475-6f4h3cck 771 24 time time NN cord-267475-6f4h3cck 771 25 around around IN cord-267475-6f4h3cck 771 26 Cortner Cortner NNP cord-267475-6f4h3cck 771 27 and and CC cord-267475-6f4h3cck 771 28 Farnham Farnham NNP cord-267475-6f4h3cck 771 29 , , , cord-267475-6f4h3cck 771 30 1990 1990 CD cord-267475-6f4h3cck 771 31 ; ; : cord-267475-6f4h3cck 771 32 Déjardin Déjardin NNP cord-267475-6f4h3cck 771 33 et et NNP cord-267475-6f4h3cck 771 34 al al NNP cord-267475-6f4h3cck 771 35 . . . cord-267475-6f4h3cck 772 1 , , , cord-267475-6f4h3cck 772 2 2000 2000 CD cord-267475-6f4h3cck 772 3 ; ; : cord-267475-6f4h3cck 772 4 Deng Deng NNP cord-267475-6f4h3cck 772 5 et et NNP cord-267475-6f4h3cck 772 6 al al NNP cord-267475-6f4h3cck 772 7 . . . cord-267475-6f4h3cck 773 1 , , , cord-267475-6f4h3cck 773 2 2002 2002 CD cord-267475-6f4h3cck 773 3 ; ; : cord-267475-6f4h3cck 773 4 Frost Frost NNP cord-267475-6f4h3cck 773 5 et et FW cord-267475-6f4h3cck 773 6 al al NNP cord-267475-6f4h3cck 773 7 . . NNP cord-267475-6f4h3cck 773 8 , , , cord-267475-6f4h3cck 773 9 2000 2000 CD cord-267475-6f4h3cck 773 10 ; ; : cord-267475-6f4h3cck 773 11 Grundhoff Grundhoff NNP cord-267475-6f4h3cck 773 12 and and CC cord-267475-6f4h3cck 773 13 Ganem Ganem NNP cord-267475-6f4h3cck 773 14 , , , cord-267475-6f4h3cck 773 15 2001 2001 CD cord-267475-6f4h3cck 773 16 ; ; : cord-267475-6f4h3cck 773 17 Jordan Jordan NNP cord-267475-6f4h3cck 773 18 et et NNP cord-267475-6f4h3cck 773 19 al al NNP cord-267475-6f4h3cck 773 20 . . NNP cord-267475-6f4h3cck 773 21 , , , cord-267475-6f4h3cck 773 22 1996 1996 CD cord-267475-6f4h3cck 773 23 ; ; : cord-267475-6f4h3cck 773 24 Kastner Kastner NNP cord-267475-6f4h3cck 773 25 et et NNP cord-267475-6f4h3cck 773 26 al al NNP cord-267475-6f4h3cck 773 27 . . NNP cord-267475-6f4h3cck 773 28 , , , cord-267475-6f4h3cck 773 29 1990b 1990b CD cord-267475-6f4h3cck 773 30 ; ; : cord-267475-6f4h3cck 773 31 Kiss Kiss NNP cord-267475-6f4h3cck 773 32 - - HYPH cord-267475-6f4h3cck 773 33 László László NNP cord-267475-6f4h3cck 773 34 et et NNP cord-267475-6f4h3cck 773 35 al al NNP cord-267475-6f4h3cck 773 36 . . NNP cord-267475-6f4h3cck 773 37 , , , cord-267475-6f4h3cck 773 38 1995 1995 CD cord-267475-6f4h3cck 773 39 ; ; : cord-267475-6f4h3cck 773 40 Laurin Laurin NNP cord-267475-6f4h3cck 773 41 et et NNP cord-267475-6f4h3cck 773 42 al al NNP cord-267475-6f4h3cck 773 43 . . NNP cord-267475-6f4h3cck 773 44 , , , cord-267475-6f4h3cck 773 45 2000 2000 CD cord-267475-6f4h3cck 773 46 ; ; : cord-267475-6f4h3cck 773 47 Peremyslov Peremyslov NNP cord-267475-6f4h3cck 773 48 and and CC cord-267475-6f4h3cck 773 49 Dolja Dolja NNP cord-267475-6f4h3cck 773 50 , , , cord-267475-6f4h3cck 773 51 2002 2002 CD cord-267475-6f4h3cck 773 52 ; ; : cord-267475-6f4h3cck 773 53 Zhang Zhang NNP cord-267475-6f4h3cck 773 54 and and CC cord-267475-6f4h3cck 773 55 Liu Liu NNP cord-267475-6f4h3cck 773 56 , , , cord-267475-6f4h3cck 773 57 2000 2000 CD cord-267475-6f4h3cck 773 58 ; ; : cord-267475-6f4h3cck 773 59 Zheng Zheng NNP cord-267475-6f4h3cck 773 60 et et NNP cord-267475-6f4h3cck 773 61 al al NNP cord-267475-6f4h3cck 773 62 . . NNP cord-267475-6f4h3cck 773 63 , , , cord-267475-6f4h3cck 773 64 1994 1994 CD cord-267475-6f4h3cck 773 65 ) ) -RRB- cord-267475-6f4h3cck 773 66 . . . cord-267475-6f4h3cck 774 1 In in IN cord-267475-6f4h3cck 774 2 vitro vitro FW cord-267475-6f4h3cck 774 3 translation translation NN cord-267475-6f4h3cck 774 4 assays assay NNS cord-267475-6f4h3cck 774 5 pose pose VBP cord-267475-6f4h3cck 774 6 a a DT cord-267475-6f4h3cck 774 7 different different JJ cord-267475-6f4h3cck 774 8 set set NN cord-267475-6f4h3cck 774 9 of of IN cord-267475-6f4h3cck 774 10 problems problem NNS cord-267475-6f4h3cck 774 11 . . . cord-267475-6f4h3cck 775 1 The the DT cord-267475-6f4h3cck 775 2 commercial commercial JJ cord-267475-6f4h3cck 775 3 availability availability NN cord-267475-6f4h3cck 775 4 of of IN cord-267475-6f4h3cck 775 5 in in FW cord-267475-6f4h3cck 775 6 vitro vitro FW cord-267475-6f4h3cck 775 7 translation translation NN cord-267475-6f4h3cck 775 8 kits kit NNS cord-267475-6f4h3cck 775 9 is be VBZ cord-267475-6f4h3cck 775 10 both both CC cord-267475-6f4h3cck 775 11 a a DT cord-267475-6f4h3cck 775 12 blessing blessing NN cord-267475-6f4h3cck 775 13 -the -the ADD cord-267475-6f4h3cck 775 14 systems system NNS cord-267475-6f4h3cck 775 15 are be VBP cord-267475-6f4h3cck 775 16 easy easy JJ cord-267475-6f4h3cck 775 17 to to TO cord-267475-6f4h3cck 775 18 useand useand VB cord-267475-6f4h3cck 775 19 a a DT cord-267475-6f4h3cck 775 20 curse curse NN cord-267475-6f4h3cck 775 21 . . . cord-267475-6f4h3cck 776 1 The the DT cord-267475-6f4h3cck 776 2 latter latter JJ cord-267475-6f4h3cck 776 3 because because IN cord-267475-6f4h3cck 776 4 insufficient insufficient JJ cord-267475-6f4h3cck 776 5 attention attention NN cord-267475-6f4h3cck 776 6 is be VBZ cord-267475-6f4h3cck 776 7 paid pay VBN cord-267475-6f4h3cck 776 8 to to IN cord-267475-6f4h3cck 776 9 reaction reaction NN cord-267475-6f4h3cck 776 10 conditions condition NNS cord-267475-6f4h3cck 776 11 that that WDT cord-267475-6f4h3cck 776 12 can can MD cord-267475-6f4h3cck 776 13 affect affect VB cord-267475-6f4h3cck 776 14 the the DT cord-267475-6f4h3cck 776 15 selection selection NN cord-267475-6f4h3cck 776 16 of of IN cord-267475-6f4h3cck 776 17 AUG AUG NNP cord-267475-6f4h3cck 776 18 start start NN cord-267475-6f4h3cck 776 19 codons codon NNS cord-267475-6f4h3cck 776 20 . . . cord-267475-6f4h3cck 777 1 When when WRB cord-267475-6f4h3cck 777 2 the the DT cord-267475-6f4h3cck 777 3 magnesium magnesium NN cord-267475-6f4h3cck 777 4 concentration concentration NN cord-267475-6f4h3cck 777 5 is be VBZ cord-267475-6f4h3cck 777 6 too too RB cord-267475-6f4h3cck 777 7 low low JJ cord-267475-6f4h3cck 777 8 , , , cord-267475-6f4h3cck 777 9 the the DT cord-267475-6f4h3cck 777 10 first first JJ cord-267475-6f4h3cck 777 11 AUG AUG NNP cord-267475-6f4h3cck 777 12 codon codon NN cord-267475-6f4h3cck 777 13 may may MD cord-267475-6f4h3cck 777 14 be be VB cord-267475-6f4h3cck 777 15 bypassed bypass VBN cord-267475-6f4h3cck 777 16 despite despite IN cord-267475-6f4h3cck 777 17 an an DT cord-267475-6f4h3cck 777 18 adequate adequate JJ cord-267475-6f4h3cck 777 19 context context NN cord-267475-6f4h3cck 777 20 ; ; : cord-267475-6f4h3cck 777 21 when when WRB cord-267475-6f4h3cck 777 22 the the DT cord-267475-6f4h3cck 777 23 magnesium magnesium NN cord-267475-6f4h3cck 777 24 concentration concentration NN cord-267475-6f4h3cck 777 25 is be VBZ cord-267475-6f4h3cck 777 26 too too RB cord-267475-6f4h3cck 777 27 high high JJ cord-267475-6f4h3cck 777 28 , , , cord-267475-6f4h3cck 777 29 initiation initiation NN cord-267475-6f4h3cck 777 30 may may MD cord-267475-6f4h3cck 777 31 occur occur VB cord-267475-6f4h3cck 777 32 at at IN cord-267475-6f4h3cck 777 33 upstream upstream JJ cord-267475-6f4h3cck 777 34 non non JJ cord-267475-6f4h3cck 777 35 - - JJ cord-267475-6f4h3cck 777 36 AUG AUG NNP cord-267475-6f4h3cck 777 37 codons codon NNS cord-267475-6f4h3cck 777 38 that that WDT cord-267475-6f4h3cck 777 39 are be VBP cord-267475-6f4h3cck 777 40 not not RB cord-267475-6f4h3cck 777 41 naturally naturally RB cord-267475-6f4h3cck 777 42 used use VBN cord-267475-6f4h3cck 777 43 . . . cord-267475-6f4h3cck 778 1 One one CD cord-267475-6f4h3cck 778 2 solution solution NN cord-267475-6f4h3cck 778 3 is be VBZ cord-267475-6f4h3cck 778 4 to to TO cord-267475-6f4h3cck 778 5 include include VB cord-267475-6f4h3cck 778 6 control control NN cord-267475-6f4h3cck 778 7 transcripts transcript NNS cord-267475-6f4h3cck 778 8 for for IN cord-267475-6f4h3cck 778 9 which which WDT cord-267475-6f4h3cck 778 10 start start NN cord-267475-6f4h3cck 778 11 - - HYPH cord-267475-6f4h3cck 778 12 codon codon NN cord-267475-6f4h3cck 778 13 selection selection NN cord-267475-6f4h3cck 778 14 was be VBD cord-267475-6f4h3cck 778 15 determined determine VBN cord-267475-6f4h3cck 778 16 in in IN cord-267475-6f4h3cck 778 17 vivo vivo NN cord-267475-6f4h3cck 778 18 , , , cord-267475-6f4h3cck 778 19 and and CC cord-267475-6f4h3cck 778 20 to to TO cord-267475-6f4h3cck 778 21 adjust adjust VB cord-267475-6f4h3cck 778 22 the the DT cord-267475-6f4h3cck 778 23 in in FW cord-267475-6f4h3cck 778 24 vitro vitro FW cord-267475-6f4h3cck 778 25 reaction reaction NN cord-267475-6f4h3cck 778 26 conditions condition NNS cord-267475-6f4h3cck 778 27 to to TO cord-267475-6f4h3cck 778 28 give give VB cord-267475-6f4h3cck 778 29 the the DT cord-267475-6f4h3cck 778 30 same same JJ cord-267475-6f4h3cck 778 31 result result NN cord-267475-6f4h3cck 778 32 ( ( -LRB- cord-267475-6f4h3cck 778 33 Kozak Kozak NNP cord-267475-6f4h3cck 778 34 , , , cord-267475-6f4h3cck 778 35 1990b 1990b CD cord-267475-6f4h3cck 778 36 ) ) -RRB- cord-267475-6f4h3cck 778 37 . . . cord-267475-6f4h3cck 779 1 Some some DT cord-267475-6f4h3cck 779 2 suppliers supplier NNS cord-267475-6f4h3cck 779 3 of of IN cord-267475-6f4h3cck 779 4 translation translation NN cord-267475-6f4h3cck 779 5 kits kit NNS cord-267475-6f4h3cck 779 6 make make VBP cord-267475-6f4h3cck 779 7 it -PRON- PRP cord-267475-6f4h3cck 779 8 possible possible JJ cord-267475-6f4h3cck 779 9 to to TO cord-267475-6f4h3cck 779 10 adjust adjust VB cord-267475-6f4h3cck 779 11 the the DT cord-267475-6f4h3cck 779 12 magnesium magnesium NN cord-267475-6f4h3cck 779 13 concentration concentration NN cord-267475-6f4h3cck 779 14 , , , cord-267475-6f4h3cck 779 15 but but CC cord-267475-6f4h3cck 779 16 there there EX cord-267475-6f4h3cck 779 17 is be VBZ cord-267475-6f4h3cck 779 18 little little JJ cord-267475-6f4h3cck 779 19 awareness awareness NN cord-267475-6f4h3cck 779 20 of of IN cord-267475-6f4h3cck 779 21 the the DT cord-267475-6f4h3cck 779 22 need need NN cord-267475-6f4h3cck 779 23 to to TO cord-267475-6f4h3cck 779 24 do do VB cord-267475-6f4h3cck 779 25 so so RB cord-267475-6f4h3cck 779 26 and and CC cord-267475-6f4h3cck 780 1 the the DT cord-267475-6f4h3cck 780 2 use use NN cord-267475-6f4h3cck 780 3 of of IN cord-267475-6f4h3cck 780 4 coupled coupled JJ cord-267475-6f4h3cck 780 5 transcription transcription NN cord-267475-6f4h3cck 780 6 / / SYM cord-267475-6f4h3cck 780 7 translation translation NN cord-267475-6f4h3cck 780 8 systems system NNS cord-267475-6f4h3cck 780 9 makes make VBZ cord-267475-6f4h3cck 780 10 it -PRON- PRP cord-267475-6f4h3cck 780 11 difficult difficult JJ cord-267475-6f4h3cck 780 12 . . . cord-267475-6f4h3cck 781 1 For for IN cord-267475-6f4h3cck 781 2 whatever whatever WDT cord-267475-6f4h3cck 781 3 reason reason NN cord-267475-6f4h3cck 781 4 , , , cord-267475-6f4h3cck 781 5 in in IN cord-267475-6f4h3cck 781 6 vitro vitro FW cord-267475-6f4h3cck 781 7 translation translation NN cord-267475-6f4h3cck 781 8 results result NNS cord-267475-6f4h3cck 781 9 sometimes sometimes RB cord-267475-6f4h3cck 781 10 deviate deviate VBP cord-267475-6f4h3cck 781 11 significantly significantly RB cord-267475-6f4h3cck 781 12 from from IN cord-267475-6f4h3cck 781 13 what what WP cord-267475-6f4h3cck 781 14 is be VBZ cord-267475-6f4h3cck 781 15 seen see VBN cord-267475-6f4h3cck 781 16 in in IN cord-267475-6f4h3cck 781 17 vivo vivo NN cord-267475-6f4h3cck 782 1 vis vis FW cord-267475-6f4h3cck 782 2 - - HYPH cord-267475-6f4h3cck 782 3 àvis àvis RP cord-267475-6f4h3cck 782 4 access access NN cord-267475-6f4h3cck 782 5 to to IN cord-267475-6f4h3cck 782 6 internal internal JJ cord-267475-6f4h3cck 782 7 AUG AUG NNP cord-267475-6f4h3cck 782 8 codons codon NNS cord-267475-6f4h3cck 782 9 ( ( -LRB- cord-267475-6f4h3cck 782 10 Grove Grove NNP cord-267475-6f4h3cck 782 11 et et NNP cord-267475-6f4h3cck 782 12 al al NNP cord-267475-6f4h3cck 782 13 . . NNP cord-267475-6f4h3cck 782 14 , , , cord-267475-6f4h3cck 782 15 1991 1991 CD cord-267475-6f4h3cck 782 16 ; ; : cord-267475-6f4h3cck 782 17 Land Land NNP cord-267475-6f4h3cck 782 18 and and CC cord-267475-6f4h3cck 782 19 Rouault Rouault NNP cord-267475-6f4h3cck 782 20 , , , cord-267475-6f4h3cck 782 21 1998 1998 CD cord-267475-6f4h3cck 782 22 ; ; : cord-267475-6f4h3cck 783 1 Meijer Meijer NNP cord-267475-6f4h3cck 783 2 et et NNP cord-267475-6f4h3cck 783 3 al al NNP cord-267475-6f4h3cck 783 4 . . NNP cord-267475-6f4h3cck 783 5 , , , cord-267475-6f4h3cck 783 6 2000 2000 CD cord-267475-6f4h3cck 784 1 ; ; : cord-267475-6f4h3cck 784 2 Meulewaeter Meulewaeter NNP cord-267475-6f4h3cck 784 3 et et NNP cord-267475-6f4h3cck 784 4 al al NNP cord-267475-6f4h3cck 784 5 . . NNP cord-267475-6f4h3cck 784 6 , , , cord-267475-6f4h3cck 784 7 1992 1992 CD cord-267475-6f4h3cck 784 8 ; ; : cord-267475-6f4h3cck 784 9 Mitchelmore Mitchelmore NNP cord-267475-6f4h3cck 784 10 et et NNP cord-267475-6f4h3cck 784 11 al al NNP cord-267475-6f4h3cck 784 12 . . . cord-267475-6f4h3cck 785 1 , , , cord-267475-6f4h3cck 785 2 2002 2002 CD cord-267475-6f4h3cck 785 3 ; ; : cord-267475-6f4h3cck 785 4 Saucedo Saucedo NNP cord-267475-6f4h3cck 785 5 et et NNP cord-267475-6f4h3cck 785 6 al al NNP cord-267475-6f4h3cck 785 7 . . NNP cord-267475-6f4h3cck 785 8 , , , cord-267475-6f4h3cck 785 9 1999 1999 CD cord-267475-6f4h3cck 785 10 ) ) -RRB- cord-267475-6f4h3cck 785 11 and and CC cord-267475-6f4h3cck 785 12 the the DT cord-267475-6f4h3cck 785 13 degree degree NN cord-267475-6f4h3cck 785 14 of of IN cord-267475-6f4h3cck 785 15 inhibition inhibition NN cord-267475-6f4h3cck 785 16 caused cause VBN cord-267475-6f4h3cck 785 17 by by IN cord-267475-6f4h3cck 785 18 small small JJ cord-267475-6f4h3cck 785 19 upORFs uporfs NN cord-267475-6f4h3cck 786 1 ( ( -LRB- cord-267475-6f4h3cck 786 2 Ghilardi Ghilardi NNP cord-267475-6f4h3cck 786 3 et et NNP cord-267475-6f4h3cck 786 4 al al NNP cord-267475-6f4h3cck 786 5 . . . cord-267475-6f4h3cck 787 1 , , , cord-267475-6f4h3cck 787 2 1998 1998 CD cord-267475-6f4h3cck 787 3 ; ; : cord-267475-6f4h3cck 787 4 Harigai Harigai NNP cord-267475-6f4h3cck 787 5 et et NNP cord-267475-6f4h3cck 787 6 al al NNP cord-267475-6f4h3cck 787 7 . . . cord-267475-6f4h3cck 788 1 , , , cord-267475-6f4h3cck 788 2 1996 1996 CD cord-267475-6f4h3cck 788 3 ; ; : cord-267475-6f4h3cck 788 4 Pecqueur Pecqueur NNP cord-267475-6f4h3cck 788 5 et et NNP cord-267475-6f4h3cck 788 6 al al NNP cord-267475-6f4h3cck 788 7 . . NNP cord-267475-6f4h3cck 788 8 , , , cord-267475-6f4h3cck 788 9 1999 1999 CD cord-267475-6f4h3cck 789 1 Pecqueur Pecqueur NNP cord-267475-6f4h3cck 789 2 et et FW cord-267475-6f4h3cck 789 3 al al NNP cord-267475-6f4h3cck 789 4 . . . cord-267475-6f4h3cck 790 1 , , , cord-267475-6f4h3cck 790 2 , , , cord-267475-6f4h3cck 790 3 2001 2001 CD cord-267475-6f4h3cck 790 4 Tanaka Tanaka NNP cord-267475-6f4h3cck 790 5 et et NNP cord-267475-6f4h3cck 790 6 al al NNP cord-267475-6f4h3cck 790 7 . . NNP cord-267475-6f4h3cck 790 8 , , , cord-267475-6f4h3cck 790 9 2001 2001 CD cord-267475-6f4h3cck 790 10 ; ; : cord-267475-6f4h3cck 790 11 Wang Wang NNP cord-267475-6f4h3cck 790 12 and and CC cord-267475-6f4h3cck 790 13 Wessler Wessler NNP cord-267475-6f4h3cck 790 14 , , , cord-267475-6f4h3cck 790 15 1998 1998 CD cord-267475-6f4h3cck 790 16 ) ) -RRB- cord-267475-6f4h3cck 790 17 . . . cord-267475-6f4h3cck 791 1 The the DT cord-267475-6f4h3cck 791 2 fidelity fidelity NN cord-267475-6f4h3cck 791 3 of of IN cord-267475-6f4h3cck 791 4 initiation initiation NN cord-267475-6f4h3cck 791 5 in in IN cord-267475-6f4h3cck 791 6 vitro vitro FW cord-267475-6f4h3cck 791 7 is be VBZ cord-267475-6f4h3cck 791 8 clearly clearly RB cord-267475-6f4h3cck 791 9 impaired impair VBN cord-267475-6f4h3cck 791 10 , , , cord-267475-6f4h3cck 791 11 possibly possibly RB cord-267475-6f4h3cck 791 12 due due IN cord-267475-6f4h3cck 791 13 to to IN cord-267475-6f4h3cck 791 14 degradation degradation NN cord-267475-6f4h3cck 791 15 of of IN cord-267475-6f4h3cck 791 16 the the DT cord-267475-6f4h3cck 791 17 mRNA mrna NN cord-267475-6f4h3cck 791 18 , , , cord-267475-6f4h3cck 791 19 in in IN cord-267475-6f4h3cck 791 20 cases case NNS cord-267475-6f4h3cck 791 21 where where WRB cord-267475-6f4h3cck 791 22 extraneous extraneous JJ cord-267475-6f4h3cck 791 23 , , , cord-267475-6f4h3cck 791 24 low low JJ cord-267475-6f4h3cck 791 25 molecule molecule NN cord-267475-6f4h3cck 791 26 weight weight NN cord-267475-6f4h3cck 791 27 polypeptides polypeptide NNS cord-267475-6f4h3cck 791 28 are be VBP cord-267475-6f4h3cck 791 29 produced produce VBN cord-267475-6f4h3cck 791 30 ( ( -LRB- cord-267475-6f4h3cck 791 31 Herbert Herbert NNP cord-267475-6f4h3cck 791 32 et et NNP cord-267475-6f4h3cck 791 33 al al NNP cord-267475-6f4h3cck 791 34 . . . cord-267475-6f4h3cck 792 1 , , , cord-267475-6f4h3cck 792 2 1996 1996 CD cord-267475-6f4h3cck 792 3 ; ; : cord-267475-6f4h3cck 792 4 Liu Liu NNP cord-267475-6f4h3cck 792 5 and and CC cord-267475-6f4h3cck 792 6 Biegalke Biegalke NNP cord-267475-6f4h3cck 792 7 , , , cord-267475-6f4h3cck 792 8 2002 2002 CD cord-267475-6f4h3cck 792 9 ; ; : cord-267475-6f4h3cck 792 10 Lekven Lekven NNP cord-267475-6f4h3cck 792 11 et et NNP cord-267475-6f4h3cck 792 12 al al NNP cord-267475-6f4h3cck 792 13 . . NNP cord-267475-6f4h3cck 792 14 , , , cord-267475-6f4h3cck 792 15 2001 2001 CD cord-267475-6f4h3cck 792 16 , , , cord-267475-6f4h3cck 792 17 Fig Fig NNP cord-267475-6f4h3cck 792 18 . . NNP cord-267475-6f4h3cck 792 19 3C 3c NN cord-267475-6f4h3cck 792 20 ; ; : cord-267475-6f4h3cck 792 21 Maser Maser NNP cord-267475-6f4h3cck 792 22 et et NNP cord-267475-6f4h3cck 792 23 al al NNP cord-267475-6f4h3cck 792 24 . . . cord-267475-6f4h3cck 793 1 , , , cord-267475-6f4h3cck 793 2 2001 2001 CD cord-267475-6f4h3cck 793 3 , , , cord-267475-6f4h3cck 793 4 Fig Fig NNP cord-267475-6f4h3cck 793 5 . . NNP cord-267475-6f4h3cck 793 6 4b 4b CD cord-267475-6f4h3cck 793 7 ; ; : cord-267475-6f4h3cck 793 8 Packham Packham NNP cord-267475-6f4h3cck 793 9 et et NNP cord-267475-6f4h3cck 793 10 al al NNP cord-267475-6f4h3cck 793 11 . . NNP cord-267475-6f4h3cck 793 12 , , , cord-267475-6f4h3cck 793 13 1997 1997 CD cord-267475-6f4h3cck 793 14 , , , cord-267475-6f4h3cck 793 15 Fig Fig NNP cord-267475-6f4h3cck 793 16 . . NNP cord-267475-6f4h3cck 793 17 5 5 CD cord-267475-6f4h3cck 793 18 ) ) -RRB- cord-267475-6f4h3cck 793 19 . . . cord-267475-6f4h3cck 794 1 The the DT cord-267475-6f4h3cck 794 2 possibility possibility NN cord-267475-6f4h3cck 794 3 that that IN cord-267475-6f4h3cck 794 4 the the DT cord-267475-6f4h3cck 794 5 input input NN cord-267475-6f4h3cck 794 6 mRNA mrna NN cord-267475-6f4h3cck 794 7 might may MD cord-267475-6f4h3cck 794 8 undergo undergo VB cord-267475-6f4h3cck 794 9 cleavage cleavage NN cord-267475-6f4h3cck 794 10 during during IN cord-267475-6f4h3cck 794 11 incubation incubation NN cord-267475-6f4h3cck 794 12 in in IN cord-267475-6f4h3cck 794 13 vitro vitro FW cord-267475-6f4h3cck 794 14 complicates complicate VBZ cord-267475-6f4h3cck 794 15 attempts attempt NNS cord-267475-6f4h3cck 794 16 to to TO cord-267475-6f4h3cck 794 17 study study VB cord-267475-6f4h3cck 794 18 the the DT cord-267475-6f4h3cck 794 19 expression expression NN cord-267475-6f4h3cck 794 20 of of IN cord-267475-6f4h3cck 794 21 dicistronic dicistronic NNP cord-267475-6f4h3cck 794 22 mRNAs mRNAs NNPS cord-267475-6f4h3cck 794 23 , , , cord-267475-6f4h3cck 794 24 as as IN cord-267475-6f4h3cck 794 25 discussed discuss VBN cord-267475-6f4h3cck 794 26 in in IN cord-267475-6f4h3cck 794 27 the the DT cord-267475-6f4h3cck 794 28 next next JJ cord-267475-6f4h3cck 794 29 section section NN cord-267475-6f4h3cck 794 30 . . . cord-267475-6f4h3cck 795 1 This this DT cord-267475-6f4h3cck 795 2 type type NN cord-267475-6f4h3cck 795 3 of of IN cord-267475-6f4h3cck 795 4 artifact artifact NN cord-267475-6f4h3cck 795 5 is be VBZ cord-267475-6f4h3cck 795 6 not not RB cord-267475-6f4h3cck 795 7 ruled rule VBN cord-267475-6f4h3cck 795 8 out out RP cord-267475-6f4h3cck 795 9 by by IN cord-267475-6f4h3cck 795 10 finding find VBG cord-267475-6f4h3cck 795 11 that that IN cord-267475-6f4h3cck 795 12 only only RB cord-267475-6f4h3cck 795 13 certain certain JJ cord-267475-6f4h3cck 795 14 downstream downstream JJ cord-267475-6f4h3cck 795 15 ORFs orf NNS cord-267475-6f4h3cck 795 16 are be VBP cord-267475-6f4h3cck 795 17 translated translate VBN cord-267475-6f4h3cck 795 18 ( ( -LRB- cord-267475-6f4h3cck 795 19 O'Connor O'Connor NNP cord-267475-6f4h3cck 795 20 and and CC cord-267475-6f4h3cck 795 21 Brian Brian NNP cord-267475-6f4h3cck 795 22 , , , cord-267475-6f4h3cck 795 23 2000 2000 CD cord-267475-6f4h3cck 795 24 ) ) -RRB- cord-267475-6f4h3cck 795 25 . . . cord-267475-6f4h3cck 796 1 Extrapolating extrapolate VBG cord-267475-6f4h3cck 796 2 from from IN cord-267475-6f4h3cck 796 3 what what WP cord-267475-6f4h3cck 796 4 is be VBZ cord-267475-6f4h3cck 796 5 seen see VBN cord-267475-6f4h3cck 796 6 when when WRB cord-267475-6f4h3cck 796 7 mRNAs mrna NNS cord-267475-6f4h3cck 796 8 are be VBP cord-267475-6f4h3cck 796 9 deliberately deliberately RB cord-267475-6f4h3cck 796 10 cleaved cleave VBN cord-267475-6f4h3cck 796 11 in in IN cord-267475-6f4h3cck 796 12 vivo vivo NN cord-267475-6f4h3cck 797 1 ( ( -LRB- cord-267475-6f4h3cck 797 2 Thoma Thoma NNP cord-267475-6f4h3cck 797 3 et et NNP cord-267475-6f4h3cck 797 4 al al NNP cord-267475-6f4h3cck 797 5 . . NNP cord-267475-6f4h3cck 797 6 , , , cord-267475-6f4h3cck 797 7 2001 2001 CD cord-267475-6f4h3cck 797 8 ) ) -RRB- cord-267475-6f4h3cck 797 9 , , , cord-267475-6f4h3cck 797 10 activation activation NN cord-267475-6f4h3cck 797 11 of of IN cord-267475-6f4h3cck 797 12 internal internal JJ cord-267475-6f4h3cck 797 13 start start NN cord-267475-6f4h3cck 797 14 codons codon NNS cord-267475-6f4h3cck 797 15 in in IN cord-267475-6f4h3cck 797 16 vitro vitro FW cord-267475-6f4h3cck 797 17 would would MD cord-267475-6f4h3cck 797 18 depend depend VB cord-267475-6f4h3cck 797 19 on on IN cord-267475-6f4h3cck 797 20 where where WRB cord-267475-6f4h3cck 797 21 the the DT cord-267475-6f4h3cck 797 22 accidental accidental JJ cord-267475-6f4h3cck 797 23 cleavage cleavage NN cord-267475-6f4h3cck 797 24 occurs occur VBZ cord-267475-6f4h3cck 797 25 and and CC cord-267475-6f4h3cck 797 26 whether whether IN cord-267475-6f4h3cck 797 27 the the DT cord-267475-6f4h3cck 797 28 endolytic endolytic JJ cord-267475-6f4h3cck 797 29 cleavage cleavage NN cord-267475-6f4h3cck 797 30 product product NN cord-267475-6f4h3cck 797 31 persists persist VBZ cord-267475-6f4h3cck 797 32 long long RB cord-267475-6f4h3cck 797 33 enough enough RB cord-267475-6f4h3cck 797 34 for for IN cord-267475-6f4h3cck 797 35 a a DT cord-267475-6f4h3cck 797 36 ribosome ribosome NN cord-267475-6f4h3cck 797 37 to to TO cord-267475-6f4h3cck 797 38 engage engage VB cord-267475-6f4h3cck 797 39 the the DT cord-267475-6f4h3cck 797 40 newly newly RB cord-267475-6f4h3cck 797 41 created create VBN cord-267475-6f4h3cck 797 42 5 5 CD cord-267475-6f4h3cck 797 43 0 0 CD cord-267475-6f4h3cck 797 44 end end NN cord-267475-6f4h3cck 797 45 before before IN cord-267475-6f4h3cck 797 46 exonucleases exonuclease NNS cord-267475-6f4h3cck 797 47 take take VBP cord-267475-6f4h3cck 797 48 over over RP cord-267475-6f4h3cck 797 49 . . . cord-267475-6f4h3cck 798 1 This this DT cord-267475-6f4h3cck 798 2 line line NN cord-267475-6f4h3cck 798 3 of of IN cord-267475-6f4h3cck 798 4 reasoning reasoning NN cord-267475-6f4h3cck 798 5 could could MD cord-267475-6f4h3cck 798 6 explain explain VB cord-267475-6f4h3cck 798 7 the the DT cord-267475-6f4h3cck 798 8 claim claim NN cord-267475-6f4h3cck 798 9 that that IN cord-267475-6f4h3cck 798 10 an an DT cord-267475-6f4h3cck 798 11 ' ' `` cord-267475-6f4h3cck 798 12 artificial artificial JJ cord-267475-6f4h3cck 798 13 IRES IRES NNP cord-267475-6f4h3cck 798 14 ' ' '' cord-267475-6f4h3cck 798 15 , , , cord-267475-6f4h3cck 798 16 consisting consist VBG cord-267475-6f4h3cck 798 17 of of IN cord-267475-6f4h3cck 798 18 a a DT cord-267475-6f4h3cck 798 19 multiple multiple JJ cord-267475-6f4h3cck 798 20 cloning clone VBG cord-267475-6f4h3cck 798 21 region region NN cord-267475-6f4h3cck 798 22 and and CC cord-267475-6f4h3cck 798 23 a a DT cord-267475-6f4h3cck 798 24 portion portion NN cord-267475-6f4h3cck 798 25 of of IN cord-267475-6f4h3cck 798 26 the the DT cord-267475-6f4h3cck 798 27 Escherichia Escherichia NNP cord-267475-6f4h3cck 798 28 coli coli NNS cord-267475-6f4h3cck 798 29 lacI lacI NNP cord-267475-6f4h3cck 798 30 gene gene NN cord-267475-6f4h3cck 798 31 , , , cord-267475-6f4h3cck 798 32 supports support VBZ cord-267475-6f4h3cck 798 33 internal internal JJ cord-267475-6f4h3cck 798 34 initiation initiation NN cord-267475-6f4h3cck 798 35 of of IN cord-267475-6f4h3cck 798 36 translation translation NN cord-267475-6f4h3cck 798 37 in in IN cord-267475-6f4h3cck 798 38 starved starved JJ cord-267475-6f4h3cck 798 39 yeast yeast NN cord-267475-6f4h3cck 798 40 cells cell NNS cord-267475-6f4h3cck 798 41 ( ( -LRB- cord-267475-6f4h3cck 798 42 Paz Paz NNP cord-267475-6f4h3cck 798 43 et et NNP cord-267475-6f4h3cck 798 44 al al NNP cord-267475-6f4h3cck 798 45 . . NNP cord-267475-6f4h3cck 798 46 , , , cord-267475-6f4h3cck 798 47 1999 1999 CD cord-267475-6f4h3cck 798 48 ) ) -RRB- cord-267475-6f4h3cck 798 49 : : : cord-267475-6f4h3cck 798 50 starvation starvation NN cord-267475-6f4h3cck 798 51 is be VBZ cord-267475-6f4h3cck 798 52 likely likely JJ cord-267475-6f4h3cck 798 53 to to TO cord-267475-6f4h3cck 798 54 promote promote VB cord-267475-6f4h3cck 798 55 mRNA mRNA NNP cord-267475-6f4h3cck 798 56 degradation degradation NN cord-267475-6f4h3cck 798 57 , , , cord-267475-6f4h3cck 798 58 and and CC cord-267475-6f4h3cck 798 59 the the DT cord-267475-6f4h3cck 798 60 ' ' `` cord-267475-6f4h3cck 798 61 IRES IRES NNP cord-267475-6f4h3cck 798 62 ' ' '' cord-267475-6f4h3cck 798 63 might may MD cord-267475-6f4h3cck 798 64 fortuitously fortuitously RB cord-267475-6f4h3cck 798 65 stabilize stabilize VB cord-267475-6f4h3cck 798 66 certain certain JJ cord-267475-6f4h3cck 798 67 intermediates intermediate NNS cord-267475-6f4h3cck 798 68 in in IN cord-267475-6f4h3cck 798 69 degradation degradation NN cord-267475-6f4h3cck 798 70 . . . cord-267475-6f4h3cck 799 1 The the DT cord-267475-6f4h3cck 799 2 discovery discovery NN cord-267475-6f4h3cck 799 3 that that IN cord-267475-6f4h3cck 799 4 IRES ires JJ cord-267475-6f4h3cck 799 5 elements element NNS cord-267475-6f4h3cck 799 6 are be VBP cord-267475-6f4h3cck 799 7 actually actually RB cord-267475-6f4h3cck 799 8 targeted target VBN cord-267475-6f4h3cck 799 9 by by IN cord-267475-6f4h3cck 799 10 some some DT cord-267475-6f4h3cck 799 11 ribonucleases ribonuclease NNS cord-267475-6f4h3cck 799 12 ( ( -LRB- cord-267475-6f4h3cck 799 13 Elgadi Elgadi NNP cord-267475-6f4h3cck 799 14 and and CC cord-267475-6f4h3cck 799 15 Smiley Smiley NNP cord-267475-6f4h3cck 799 16 , , , cord-267475-6f4h3cck 799 17 1999 1999 CD cord-267475-6f4h3cck 799 18 ; ; : cord-267475-6f4h3cck 799 19 Nadal Nadal NNP cord-267475-6f4h3cck 799 20 et et NNP cord-267475-6f4h3cck 799 21 al al NNP cord-267475-6f4h3cck 799 22 . . NNP cord-267475-6f4h3cck 799 23 , , , cord-267475-6f4h3cck 799 24 2002 2002 CD cord-267475-6f4h3cck 799 25 ) ) -RRB- cord-267475-6f4h3cck 799 26 should should MD cord-267475-6f4h3cck 799 27 be be VB cord-267475-6f4h3cck 799 28 remembered remember VBN cord-267475-6f4h3cck 799 29 . . . cord-267475-6f4h3cck 800 1 Recent recent JJ cord-267475-6f4h3cck 800 2 studies study NNS cord-267475-6f4h3cck 800 3 that that WDT cord-267475-6f4h3cck 800 4 use use VBP cord-267475-6f4h3cck 800 5 a a DT cord-267475-6f4h3cck 800 6 primer primer NN cord-267475-6f4h3cck 800 7 - - HYPH cord-267475-6f4h3cck 800 8 extension extension NN cord-267475-6f4h3cck 800 9 inhibition inhibition NN cord-267475-6f4h3cck 800 10 ( ( -LRB- cord-267475-6f4h3cck 800 11 toeprinting toeprinting NN cord-267475-6f4h3cck 800 12 ) ) -RRB- cord-267475-6f4h3cck 800 13 assay assay NN cord-267475-6f4h3cck 800 14 to to TO cord-267475-6f4h3cck 800 15 monitor monitor VB cord-267475-6f4h3cck 800 16 the the DT cord-267475-6f4h3cck 800 17 binding binding NN cord-267475-6f4h3cck 800 18 of of IN cord-267475-6f4h3cck 800 19 ribosomes ribosome NNS cord-267475-6f4h3cck 800 20 to to IN cord-267475-6f4h3cck 800 21 mRNAs mrnas PRP cord-267475-6f4h3cck 800 22 have have VB cord-267475-6f4h3cck 800 23 the the DT cord-267475-6f4h3cck 800 24 advantage advantage NN cord-267475-6f4h3cck 800 25 of of IN cord-267475-6f4h3cck 800 26 focusing focus VBG cord-267475-6f4h3cck 800 27 directly directly RB cord-267475-6f4h3cck 800 28 on on IN cord-267475-6f4h3cck 800 29 the the DT cord-267475-6f4h3cck 800 30 initiation initiation NN cord-267475-6f4h3cck 800 31 step step NN cord-267475-6f4h3cck 800 32 , , , cord-267475-6f4h3cck 800 33 but but CC cord-267475-6f4h3cck 800 34 care care NN cord-267475-6f4h3cck 800 35 is be VBZ cord-267475-6f4h3cck 800 36 needed need VBN cord-267475-6f4h3cck 800 37 to to TO cord-267475-6f4h3cck 800 38 distinguish distinguish VB cord-267475-6f4h3cck 800 39 authentic authentic JJ cord-267475-6f4h3cck 800 40 initiation initiation NN cord-267475-6f4h3cck 800 41 complexes complex NNS cord-267475-6f4h3cck 800 42 from from IN cord-267475-6f4h3cck 800 43 artifactual artifactual NNP cord-267475-6f4h3cck 800 44 pauses pause VBZ cord-267475-6f4h3cck 800 45 in in IN cord-267475-6f4h3cck 800 46 primer primer NN cord-267475-6f4h3cck 800 47 extension extension NN cord-267475-6f4h3cck 800 48 caused cause VBN cord-267475-6f4h3cck 800 49 by by IN cord-267475-6f4h3cck 800 50 base base NN cord-267475-6f4h3cck 800 51 - - HYPH cord-267475-6f4h3cck 800 52 paired pair VBN cord-267475-6f4h3cck 800 53 structures structure NNS cord-267475-6f4h3cck 800 54 or or CC cord-267475-6f4h3cck 800 55 extraneous extraneous JJ cord-267475-6f4h3cck 800 56 proteins protein NNS cord-267475-6f4h3cck 800 57 bound bind VBN cord-267475-6f4h3cck 800 58 to to IN cord-267475-6f4h3cck 800 59 the the DT cord-267475-6f4h3cck 800 60 mRNA mrna NN cord-267475-6f4h3cck 800 61 . . . cord-267475-6f4h3cck 801 1 The the DT cord-267475-6f4h3cck 801 2 complicating complicate VBG cord-267475-6f4h3cck 801 3 effects effect NNS cord-267475-6f4h3cck 801 4 of of IN cord-267475-6f4h3cck 801 5 mRNA mrna NN cord-267475-6f4h3cck 801 6 secondary secondary JJ cord-267475-6f4h3cck 801 7 structure structure NN cord-267475-6f4h3cck 801 8 , , , cord-267475-6f4h3cck 801 9 which which WDT cord-267475-6f4h3cck 801 10 are be VBP cord-267475-6f4h3cck 801 11 prominent prominent JJ cord-267475-6f4h3cck 801 12 when when WRB cord-267475-6f4h3cck 801 13 avian avian JJ cord-267475-6f4h3cck 801 14 reverse reverse NN cord-267475-6f4h3cck 801 15 transcriptase transcriptase NN cord-267475-6f4h3cck 801 16 is be VBZ cord-267475-6f4h3cck 801 17 used use VBN cord-267475-6f4h3cck 801 18 for for IN cord-267475-6f4h3cck 801 19 toeprinting toeprinting NN cord-267475-6f4h3cck 801 20 , , , cord-267475-6f4h3cck 801 21 can can MD cord-267475-6f4h3cck 801 22 be be VB cord-267475-6f4h3cck 801 23 minimized minimize VBN cord-267475-6f4h3cck 801 24 by by IN cord-267475-6f4h3cck 801 25 using use VBG cord-267475-6f4h3cck 801 26 a a DT cord-267475-6f4h3cck 801 27 form form NN cord-267475-6f4h3cck 801 28 of of IN cord-267475-6f4h3cck 801 29 the the DT cord-267475-6f4h3cck 801 30 enzyme enzyme NN cord-267475-6f4h3cck 801 31 derived derive VBN cord-267475-6f4h3cck 801 32 from from IN cord-267475-6f4h3cck 801 33 murine murine JJ cord-267475-6f4h3cck 801 34 leukemia leukemia NN cord-267475-6f4h3cck 801 35 virus virus NN cord-267475-6f4h3cck 801 36 ( ( -LRB- cord-267475-6f4h3cck 801 37 Kozak Kozak NNP cord-267475-6f4h3cck 801 38 , , , cord-267475-6f4h3cck 801 39 1998 1998 CD cord-267475-6f4h3cck 801 40 ) ) -RRB- cord-267475-6f4h3cck 801 41 . . . cord-267475-6f4h3cck 802 1 Attempts attempt NNS cord-267475-6f4h3cck 802 2 to to TO cord-267475-6f4h3cck 802 3 explain explain VB cord-267475-6f4h3cck 802 4 the the DT cord-267475-6f4h3cck 802 5 origin origin NN cord-267475-6f4h3cck 802 6 of of IN cord-267475-6f4h3cck 802 7 multiple multiple JJ cord-267475-6f4h3cck 802 8 isoforms isoform NNS cord-267475-6f4h3cck 802 9 of of IN cord-267475-6f4h3cck 802 10 eIF4 eIF4 NNP cord-267475-6f4h3cck 802 11 G G NNP cord-267475-6f4h3cck 802 12 ( ( -LRB- cord-267475-6f4h3cck 802 13 Bradley Bradley NNP cord-267475-6f4h3cck 802 14 et et NNP cord-267475-6f4h3cck 802 15 al al NNP cord-267475-6f4h3cck 802 16 . . NNP cord-267475-6f4h3cck 802 17 , , , cord-267475-6f4h3cck 802 18 2002 2002 CD cord-267475-6f4h3cck 802 19 ) ) -RRB- cord-267475-6f4h3cck 802 20 illustrate illustrate VBP cord-267475-6f4h3cck 802 21 how how WRB cord-267475-6f4h3cck 802 22 challenging challenge VBG cord-267475-6f4h3cck 802 23 it -PRON- PRP cord-267475-6f4h3cck 802 24 can can MD cord-267475-6f4h3cck 802 25 be be VB cord-267475-6f4h3cck 802 26 to to TO cord-267475-6f4h3cck 802 27 interpret interpret VB cord-267475-6f4h3cck 802 28 translation translation NN cord-267475-6f4h3cck 802 29 assays assay NNS cord-267475-6f4h3cck 802 30 . . . cord-267475-6f4h3cck 803 1 In in IN cord-267475-6f4h3cck 803 2 vitro vitro FW cord-267475-6f4h3cck 803 3 experiments experiment NNS cord-267475-6f4h3cck 803 4 presented present VBN cord-267475-6f4h3cck 803 5 in in IN cord-267475-6f4h3cck 803 6 support support NN cord-267475-6f4h3cck 803 7 of of IN cord-267475-6f4h3cck 803 8 the the DT cord-267475-6f4h3cck 803 9 idea idea NN cord-267475-6f4h3cck 803 10 that that IN cord-267475-6f4h3cck 803 11 translation translation NN cord-267475-6f4h3cck 803 12 can can MD cord-267475-6f4h3cck 803 13 initiate initiate VB cord-267475-6f4h3cck 803 14 from from IN cord-267475-6f4h3cck 803 15 five five CD cord-267475-6f4h3cck 803 16 AUG AUG NNP cord-267475-6f4h3cck 803 17 codons codon NNS cord-267475-6f4h3cck 803 18 , , , cord-267475-6f4h3cck 803 19 in in IN cord-267475-6f4h3cck 803 20 a a DT cord-267475-6f4h3cck 803 21 single single JJ cord-267475-6f4h3cck 803 22 form form NN cord-267475-6f4h3cck 803 23 of of IN cord-267475-6f4h3cck 803 24 eIF4 eIF4 NNP cord-267475-6f4h3cck 803 25 G G NNP cord-267475-6f4h3cck 803 26 mRNA mrna NN cord-267475-6f4h3cck 803 27 , , , cord-267475-6f4h3cck 803 28 might may MD cord-267475-6f4h3cck 803 29 have have VB cord-267475-6f4h3cck 803 30 been be VBN cord-267475-6f4h3cck 803 31 compromised compromise VBN cord-267475-6f4h3cck 803 32 by by IN cord-267475-6f4h3cck 803 33 mRNA mrna NN cord-267475-6f4h3cck 803 34 breakage breakage NN cord-267475-6f4h3cck 803 35 ; ; : cord-267475-6f4h3cck 803 36 this this DT cord-267475-6f4h3cck 803 37 would would MD cord-267475-6f4h3cck 803 38 explain explain VB cord-267475-6f4h3cck 803 39 the the DT cord-267475-6f4h3cck 803 40 production production NN cord-267475-6f4h3cck 803 41 of of IN cord-267475-6f4h3cck 803 42 an an DT cord-267475-6f4h3cck 803 43 array array NN cord-267475-6f4h3cck 803 44 of of IN cord-267475-6f4h3cck 803 45 extraneous extraneous JJ cord-267475-6f4h3cck 803 46 smaller small JJR cord-267475-6f4h3cck 803 47 polypeptides polypeptide NNS cord-267475-6f4h3cck 803 48 ( ( -LRB- cord-267475-6f4h3cck 803 49 Byrd Byrd NNP cord-267475-6f4h3cck 803 50 et et NNP cord-267475-6f4h3cck 803 51 al al NNP cord-267475-6f4h3cck 803 52 . . NNP cord-267475-6f4h3cck 803 53 , , , cord-267475-6f4h3cck 803 54 2002 2002 CD cord-267475-6f4h3cck 803 55 , , , cord-267475-6f4h3cck 803 56 Fig Fig NNP cord-267475-6f4h3cck 803 57 . . NNP cord-267475-6f4h3cck 803 58 3C 3C NNP cord-267475-6f4h3cck 803 59 , , , cord-267475-6f4h3cck 803 60 lanes lane VBZ cord-267475-6f4h3cck 803 61 1 1 CD cord-267475-6f4h3cck 803 62 , , , cord-267475-6f4h3cck 803 63 3 3 CD cord-267475-6f4h3cck 803 64 and and CC cord-267475-6f4h3cck 803 65 5 5 CD cord-267475-6f4h3cck 803 66 ) ) -RRB- cord-267475-6f4h3cck 803 67 . . . cord-267475-6f4h3cck 804 1 Translation translation NN cord-267475-6f4h3cck 804 2 of of IN cord-267475-6f4h3cck 804 3 some some DT cord-267475-6f4h3cck 804 4 eIF4 eif4 IN cord-267475-6f4h3cck 804 5 G g NN cord-267475-6f4h3cck 804 6 isoforms isoform NNS cord-267475-6f4h3cck 804 7 from from IN cord-267475-6f4h3cck 804 8 broken broken JJ cord-267475-6f4h3cck 804 9 mRNAs mRNAs NNPS cord-267475-6f4h3cck 804 10 could could MD cord-267475-6f4h3cck 804 11 also also RB cord-267475-6f4h3cck 804 12 explain explain VB cord-267475-6f4h3cck 804 13 the the DT cord-267475-6f4h3cck 804 14 variability variability NN cord-267475-6f4h3cck 804 15 in in IN cord-267475-6f4h3cck 804 16 yields yield NNS cord-267475-6f4h3cck 804 17 noted note VBN cord-267475-6f4h3cck 804 18 throughout throughout IN cord-267475-6f4h3cck 804 19 that that DT cord-267475-6f4h3cck 804 20 study study NN cord-267475-6f4h3cck 804 21 . . . cord-267475-6f4h3cck 805 1 When when WRB cord-267475-6f4h3cck 805 2 the the DT cord-267475-6f4h3cck 805 3 endogenous endogenous JJ cord-267475-6f4h3cck 805 4 eIF4 eIF4 NNP cord-267475-6f4h3cck 805 5 G g NN cord-267475-6f4h3cck 805 6 gene gene NN cord-267475-6f4h3cck 805 7 is be VBZ cord-267475-6f4h3cck 805 8 expressed express VBN cord-267475-6f4h3cck 805 9 in in IN cord-267475-6f4h3cck 805 10 vivo vivo NN cord-267475-6f4h3cck 805 11 , , , cord-267475-6f4h3cck 805 12 access access NN cord-267475-6f4h3cck 805 13 to to IN cord-267475-6f4h3cck 805 14 certain certain JJ cord-267475-6f4h3cck 805 15 downstream downstream JJ cord-267475-6f4h3cck 805 16 AUG AUG NNP cord-267475-6f4h3cck 805 17 codons codon NNS cord-267475-6f4h3cck 805 18 might may MD cord-267475-6f4h3cck 805 19 occur occur VB cord-267475-6f4h3cck 805 20 via via IN cord-267475-6f4h3cck 805 21 alternative alternative JJ cord-267475-6f4h3cck 805 22 splicing splicing NN cord-267475-6f4h3cck 805 23 or or CC cord-267475-6f4h3cck 805 24 internal internal JJ cord-267475-6f4h3cck 805 25 promoters promoter NNS cord-267475-6f4h3cck 805 26 ; ; : cord-267475-6f4h3cck 805 27 both both DT cord-267475-6f4h3cck 805 28 mechanisms mechanism NNS cord-267475-6f4h3cck 805 29 have have VBP cord-267475-6f4h3cck 805 30 been be VBN cord-267475-6f4h3cck 805 31 documented document VBN cord-267475-6f4h3cck 805 32 in in IN cord-267475-6f4h3cck 805 33 studies study NNS cord-267475-6f4h3cck 805 34 of of IN cord-267475-6f4h3cck 805 35 eIF4 eIF4 NNP cord-267475-6f4h3cck 805 36 G G NNP cord-267475-6f4h3cck 805 37 by by IN cord-267475-6f4h3cck 805 38 other other JJ cord-267475-6f4h3cck 805 39 investigators investigator NNS cord-267475-6f4h3cck 805 40 ( ( -LRB- cord-267475-6f4h3cck 805 41 Han Han NNP cord-267475-6f4h3cck 805 42 and and CC cord-267475-6f4h3cck 805 43 Zhang Zhang NNP cord-267475-6f4h3cck 805 44 , , , cord-267475-6f4h3cck 805 45 2002 2002 CD cord-267475-6f4h3cck 805 46 , , , cord-267475-6f4h3cck 805 47 and and CC cord-267475-6f4h3cck 805 48 references reference NNS cord-267475-6f4h3cck 805 49 therein therein RB cord-267475-6f4h3cck 805 50 ) ) -RRB- cord-267475-6f4h3cck 805 51 . . . cord-267475-6f4h3cck 806 1 Thus thus RB cord-267475-6f4h3cck 806 2 , , , cord-267475-6f4h3cck 806 3 even even RB cord-267475-6f4h3cck 806 4 though though IN cord-267475-6f4h3cck 806 5 one one PRP cord-267475-6f4h3cck 806 6 could could MD cord-267475-6f4h3cck 806 7 rationalize rationalize VB cord-267475-6f4h3cck 806 8 the the DT cord-267475-6f4h3cck 806 9 production production NN cord-267475-6f4h3cck 806 10 of of IN cord-267475-6f4h3cck 806 11 at at RB cord-267475-6f4h3cck 806 12 least least RBS cord-267475-6f4h3cck 806 13 three three CD cord-267475-6f4h3cck 806 14 isoforms isoform NNS cord-267475-6f4h3cck 806 15 of of IN cord-267475-6f4h3cck 806 16 eIF4 eIF4 NNP cord-267475-6f4h3cck 806 17 G g NN cord-267475-6f4h3cck 806 18 from from IN cord-267475-6f4h3cck 806 19 one one CD cord-267475-6f4h3cck 806 20 mRNA mrna NN cord-267475-6f4h3cck 806 21 via via IN cord-267475-6f4h3cck 806 22 established establish VBN cord-267475-6f4h3cck 806 23 translational translational JJ cord-267475-6f4h3cck 806 24 mechanisms mechanism NNS cord-267475-6f4h3cck 806 25 -an -an : cord-267475-6f4h3cck 806 26 overlapping overlap VBG cord-267475-6f4h3cck 806 27 upORF uporf NN cord-267475-6f4h3cck 806 28 could could MD cord-267475-6f4h3cck 806 29 shunt shunt VB cord-267475-6f4h3cck 806 30 some some DT cord-267475-6f4h3cck 806 31 40S 40s CD cord-267475-6f4h3cck 806 32 ribosomal ribosomal JJ cord-267475-6f4h3cck 806 33 subunits subunit NNS cord-267475-6f4h3cck 806 34 past past IN cord-267475-6f4h3cck 806 35 the the DT cord-267475-6f4h3cck 806 36 first first JJ cord-267475-6f4h3cck 806 37 in in IN cord-267475-6f4h3cck 806 38 - - HYPH cord-267475-6f4h3cck 806 39 frame frame NN cord-267475-6f4h3cck 806 40 AUG AUG NNP cord-267475-6f4h3cck 806 41 codon codon NN cord-267475-6f4h3cck 806 42 ( ( -LRB- cord-267475-6f4h3cck 806 43 position position NN cord-267475-6f4h3cck 806 44 275 275 CD cord-267475-6f4h3cck 806 45 ) ) -RRB- cord-267475-6f4h3cck 806 46 , , , cord-267475-6f4h3cck 806 47 and and CC cord-267475-6f4h3cck 806 48 the the DT cord-267475-6f4h3cck 806 49 unfavorable unfavorable JJ cord-267475-6f4h3cck 806 50 context context NN cord-267475-6f4h3cck 806 51 at at IN cord-267475-6f4h3cck 806 52 AUG AUG NNP cord-267475-6f4h3cck 806 53 395 395 CD cord-267475-6f4h3cck 806 54 might may MD cord-267475-6f4h3cck 806 55 allow allow VB cord-267475-6f4h3cck 806 56 some some DT cord-267475-6f4h3cck 806 57 ribosomes ribosome NNS cord-267475-6f4h3cck 806 58 to to TO cord-267475-6f4h3cck 806 59 reach reach VB cord-267475-6f4h3cck 806 60 AUG AUG NNP cord-267475-6f4h3cck 806 61 536 536 CD cord-267475-6f4h3cck 806 62 by by IN cord-267475-6f4h3cck 806 63 leaky leaky JJ cord-267475-6f4h3cck 806 64 scanning scanning NN cord-267475-6f4h3cck 806 65 -it -it : cord-267475-6f4h3cck 806 66 would would MD cord-267475-6f4h3cck 806 67 be be VB cord-267475-6f4h3cck 806 68 premature premature JJ cord-267475-6f4h3cck 806 69 to to TO cord-267475-6f4h3cck 806 70 propose propose VB cord-267475-6f4h3cck 806 71 that that DT cord-267475-6f4h3cck 806 72 solution solution NN cord-267475-6f4h3cck 806 73 . . . cord-267475-6f4h3cck 807 1 The the DT cord-267475-6f4h3cck 807 2 in in FW cord-267475-6f4h3cck 807 3 vitro vitro FW cord-267475-6f4h3cck 807 4 experiments experiment NNS cord-267475-6f4h3cck 807 5 need need VBP cord-267475-6f4h3cck 807 6 to to TO cord-267475-6f4h3cck 807 7 be be VB cord-267475-6f4h3cck 807 8 repeated repeat VBN cord-267475-6f4h3cck 807 9 with with IN cord-267475-6f4h3cck 807 10 careful careful JJ cord-267475-6f4h3cck 807 11 attention attention NN cord-267475-6f4h3cck 807 12 to to IN cord-267475-6f4h3cck 807 13 magnesium magnesium NN cord-267475-6f4h3cck 807 14 levels level NNS cord-267475-6f4h3cck 807 15 and and CC cord-267475-6f4h3cck 807 16 with with IN cord-267475-6f4h3cck 807 17 efforts effort NNS cord-267475-6f4h3cck 807 18 to to TO cord-267475-6f4h3cck 807 19 minimize minimize VB cord-267475-6f4h3cck 807 20 mRNA mrna NN cord-267475-6f4h3cck 807 21 breakage breakage NN cord-267475-6f4h3cck 807 22 . . . cord-267475-6f4h3cck 808 1 The the DT cord-267475-6f4h3cck 808 2 latter latter JJ cord-267475-6f4h3cck 808 3 might may MD cord-267475-6f4h3cck 808 4 be be VB cord-267475-6f4h3cck 808 5 accomplished accomplish VBN cord-267475-6f4h3cck 808 6 by by IN cord-267475-6f4h3cck 808 7 lowering lower VBG cord-267475-6f4h3cck 808 8 the the DT cord-267475-6f4h3cck 808 9 temperature temperature NN cord-267475-6f4h3cck 808 10 to to IN cord-267475-6f4h3cck 808 11 25 25 CD cord-267475-6f4h3cck 808 12 8C 8c CD cord-267475-6f4h3cck 808 13 and and CC cord-267475-6f4h3cck 808 14 limiting limit VBG cord-267475-6f4h3cck 808 15 the the DT cord-267475-6f4h3cck 808 16 window window NN cord-267475-6f4h3cck 808 17 for for IN cord-267475-6f4h3cck 808 18 initiation initiation NN cord-267475-6f4h3cck 808 19 to to IN cord-267475-6f4h3cck 808 20 5 5 CD cord-267475-6f4h3cck 808 21 or or CC cord-267475-6f4h3cck 808 22 10 10 CD cord-267475-6f4h3cck 808 23 min min NN cord-267475-6f4h3cck 808 24 . . . cord-267475-6f4h3cck 809 1 ( ( -LRB- cord-267475-6f4h3cck 809 2 Addition addition NN cord-267475-6f4h3cck 809 3 of of IN cord-267475-6f4h3cck 809 4 edeine edeine NN cord-267475-6f4h3cck 809 5 after after IN cord-267475-6f4h3cck 809 6 the the DT cord-267475-6f4h3cck 809 7 first first JJ cord-267475-6f4h3cck 809 8 5 5 CD cord-267475-6f4h3cck 809 9 or or CC cord-267475-6f4h3cck 809 10 10 10 CD cord-267475-6f4h3cck 809 11 min min NN cord-267475-6f4h3cck 809 12 , , , cord-267475-6f4h3cck 809 13 followed follow VBN cord-267475-6f4h3cck 809 14 by by IN cord-267475-6f4h3cck 809 15 another another DT cord-267475-6f4h3cck 809 16 period period NN cord-267475-6f4h3cck 809 17 of of IN cord-267475-6f4h3cck 809 18 incubation incubation NN cord-267475-6f4h3cck 809 19 , , , cord-267475-6f4h3cck 809 20 would would MD cord-267475-6f4h3cck 809 21 allow allow VB cord-267475-6f4h3cck 809 22 polypeptides polypeptide NNS cord-267475-6f4h3cck 809 23 to to TO cord-267475-6f4h3cck 809 24 be be VB cord-267475-6f4h3cck 809 25 elongated elongate VBN cord-267475-6f4h3cck 809 26 without without IN cord-267475-6f4h3cck 809 27 further further JJ cord-267475-6f4h3cck 809 28 initiation initiation NN cord-267475-6f4h3cck 809 29 events event NNS cord-267475-6f4h3cck 809 30 . . . cord-267475-6f4h3cck 809 31 ) ) -RRB- cord-267475-6f4h3cck 810 1 The the DT cord-267475-6f4h3cck 810 2 possible possible JJ cord-267475-6f4h3cck 810 3 production production NN cord-267475-6f4h3cck 810 4 of of IN cord-267475-6f4h3cck 810 5 some some DT cord-267475-6f4h3cck 810 6 eIF4 eif4 IN cord-267475-6f4h3cck 810 7 G g NN cord-267475-6f4h3cck 810 8 isoforms isoform NNS cord-267475-6f4h3cck 810 9 by by IN cord-267475-6f4h3cck 810 10 proteolysis proteolysis NN cord-267475-6f4h3cck 810 11 also also RB cord-267475-6f4h3cck 810 12 needs need VBZ cord-267475-6f4h3cck 810 13 to to TO cord-267475-6f4h3cck 810 14 be be VB cord-267475-6f4h3cck 810 15 ruled rule VBN cord-267475-6f4h3cck 810 16 out out RP cord-267475-6f4h3cck 810 17 , , , cord-267475-6f4h3cck 810 18 as as IN cord-267475-6f4h3cck 810 19 this this DT cord-267475-6f4h3cck 810 20 protein protein NN cord-267475-6f4h3cck 810 21 is be VBZ cord-267475-6f4h3cck 810 22 notoriously notoriously RB cord-267475-6f4h3cck 810 23 susceptible susceptible JJ cord-267475-6f4h3cck 810 24 to to IN cord-267475-6f4h3cck 810 25 cleavage cleavage NN cord-267475-6f4h3cck 810 26 . . . cord-267475-6f4h3cck 811 1 The the DT cord-267475-6f4h3cck 811 2 study study NN cord-267475-6f4h3cck 811 3 by by IN cord-267475-6f4h3cck 811 4 Byrd Byrd NNP cord-267475-6f4h3cck 811 5 et et NNP cord-267475-6f4h3cck 811 6 al al NNP cord-267475-6f4h3cck 811 7 . . . cord-267475-6f4h3cck 812 1 ( ( -LRB- cord-267475-6f4h3cck 812 2 2002 2002 CD cord-267475-6f4h3cck 812 3 ) ) -RRB- cord-267475-6f4h3cck 812 4 included include VBD cord-267475-6f4h3cck 812 5 experiments experiment NNS cord-267475-6f4h3cck 812 6 carried carry VBN cord-267475-6f4h3cck 812 7 out out RP cord-267475-6f4h3cck 812 8 with with IN cord-267475-6f4h3cck 812 9 dicistronic dicistronic JJ cord-267475-6f4h3cck 812 10 transcripts transcript NNS cord-267475-6f4h3cck 812 11 , , , cord-267475-6f4h3cck 812 12 predicated predicate VBN cord-267475-6f4h3cck 812 13 on on IN cord-267475-6f4h3cck 812 14 the the DT cord-267475-6f4h3cck 812 15 belief belief NN cord-267475-6f4h3cck 812 16 that that IN cord-267475-6f4h3cck 812 17 eIF4 eIF4 NNP cord-267475-6f4h3cck 812 18 G G NNP cord-267475-6f4h3cck 812 19 mRNA mrna NN cord-267475-6f4h3cck 812 20 contains contain VBZ cord-267475-6f4h3cck 812 21 IRES ires JJ cord-267475-6f4h3cck 812 22 elements element NNS cord-267475-6f4h3cck 812 23 which which WDT cord-267475-6f4h3cck 812 24 allow allow VBP cord-267475-6f4h3cck 812 25 direct direct JJ cord-267475-6f4h3cck 812 26 internal internal JJ cord-267475-6f4h3cck 812 27 initiation initiation NN cord-267475-6f4h3cck 812 28 of of IN cord-267475-6f4h3cck 812 29 translation translation NN cord-267475-6f4h3cck 812 30 . . . cord-267475-6f4h3cck 813 1 An an DT cord-267475-6f4h3cck 813 2 eIF4G/ eIF4G/ NNP cord-267475-6f4h3cck 813 3 EGFP EGFP NNP cord-267475-6f4h3cck 813 4 ( ( -LRB- cord-267475-6f4h3cck 813 5 enhanced enhance VBN cord-267475-6f4h3cck 813 6 green green JJ cord-267475-6f4h3cck 813 7 fluorescent fluorescent NN cord-267475-6f4h3cck 813 8 protein protein NN cord-267475-6f4h3cck 813 9 ) ) -RRB- cord-267475-6f4h3cck 813 10 fusion fusion NN cord-267475-6f4h3cck 813 11 gene gene NN cord-267475-6f4h3cck 813 12 positioned position VBN cord-267475-6f4h3cck 813 13 at at IN cord-267475-6f4h3cck 813 14 the the DT cord-267475-6f4h3cck 813 15 3 3 CD cord-267475-6f4h3cck 813 16 0 0 CD cord-267475-6f4h3cck 813 17 end end NN cord-267475-6f4h3cck 813 18 of of IN cord-267475-6f4h3cck 813 19 a a DT cord-267475-6f4h3cck 813 20 dicistronic dicistronic JJ cord-267475-6f4h3cck 813 21 transcript transcript NN cord-267475-6f4h3cck 813 22 was be VBD cord-267475-6f4h3cck 813 23 translatable translatable JJ cord-267475-6f4h3cck 813 24 in in IN cord-267475-6f4h3cck 813 25 vitro vitro FW cord-267475-6f4h3cck 813 26 , , , cord-267475-6f4h3cck 813 27 but but CC cord-267475-6f4h3cck 813 28 the the DT cord-267475-6f4h3cck 813 29 aforementioned aforementioned JJ cord-267475-6f4h3cck 813 30 possibility possibility NN cord-267475-6f4h3cck 813 31 of of IN cord-267475-6f4h3cck 813 32 mRNA mrna NN cord-267475-6f4h3cck 813 33 breakage breakage NN cord-267475-6f4h3cck 813 34 complicates complicate VBZ cord-267475-6f4h3cck 813 35 the the DT cord-267475-6f4h3cck 813 36 interpretation interpretation NN cord-267475-6f4h3cck 813 37 . . . cord-267475-6f4h3cck 814 1 Indeed indeed RB cord-267475-6f4h3cck 814 2 , , , cord-267475-6f4h3cck 814 3 the the DT cord-267475-6f4h3cck 814 4 unexpected unexpected JJ cord-267475-6f4h3cck 814 5 translation translation NN cord-267475-6f4h3cck 814 6 of of IN cord-267475-6f4h3cck 814 7 EGFP EGFP NNP cord-267475-6f4h3cck 814 8 from from IN cord-267475-6f4h3cck 814 9 the the DT cord-267475-6f4h3cck 814 10 3 3 CD cord-267475-6f4h3cck 814 11 0 0 CD cord-267475-6f4h3cck 814 12 position position NN cord-267475-6f4h3cck 814 13 even even RB cord-267475-6f4h3cck 814 14 without without IN cord-267475-6f4h3cck 814 15 fusion fusion NN cord-267475-6f4h3cck 814 16 to to IN cord-267475-6f4h3cck 814 17 eIF4 eIF4 NNP cord-267475-6f4h3cck 814 18 G g NN cord-267475-6f4h3cck 815 1 ( ( -LRB- cord-267475-6f4h3cck 815 2 Byrd Byrd NNP cord-267475-6f4h3cck 815 3 et et NNP cord-267475-6f4h3cck 815 4 al al NNP cord-267475-6f4h3cck 815 5 . . . cord-267475-6f4h3cck 816 1 , , , cord-267475-6f4h3cck 816 2 2002 2002 CD cord-267475-6f4h3cck 816 3 , , , cord-267475-6f4h3cck 817 1 Fig Fig NNP cord-267475-6f4h3cck 817 2 . . . cord-267475-6f4h3cck 818 1 7A 7A NNP cord-267475-6f4h3cck 818 2 , , , cord-267475-6f4h3cck 818 3 lane lane NN cord-267475-6f4h3cck 818 4 3 3 CD cord-267475-6f4h3cck 818 5 ) ) -RRB- cord-267475-6f4h3cck 818 6 is be VBZ cord-267475-6f4h3cck 818 7 most most RBS cord-267475-6f4h3cck 818 8 easily easily RB cord-267475-6f4h3cck 818 9 explained explain VBN cord-267475-6f4h3cck 818 10 by by IN cord-267475-6f4h3cck 818 11 mRNA mRNA NNP cord-267475-6f4h3cck 818 12 cleavage cleavage NN cord-267475-6f4h3cck 818 13 . . . cord-267475-6f4h3cck 819 1 ( ( -LRB- cord-267475-6f4h3cck 819 2 The the DT cord-267475-6f4h3cck 819 3 authors author NNS cord-267475-6f4h3cck 819 4 invoke invoke VBP cord-267475-6f4h3cck 819 5 reinitiation reinitiation NN cord-267475-6f4h3cck 819 6 as as IN cord-267475-6f4h3cck 819 7 the the DT cord-267475-6f4h3cck 819 8 explanation explanation NN cord-267475-6f4h3cck 819 9 , , , cord-267475-6f4h3cck 819 10 but but CC cord-267475-6f4h3cck 819 11 reinitiation reinitiation NN cord-267475-6f4h3cck 819 12 can can MD cord-267475-6f4h3cck 819 13 not not RB cord-267475-6f4h3cck 819 14 occur occur VB cord-267475-6f4h3cck 819 15 following follow VBG cord-267475-6f4h3cck 819 16 translation translation NN cord-267475-6f4h3cck 819 17 of of IN cord-267475-6f4h3cck 819 18 a a DT cord-267475-6f4h3cck 819 19 large large JJ cord-267475-6f4h3cck 819 20 5 5 CD cord-267475-6f4h3cck 819 21 0 0 CD cord-267475-6f4h3cck 819 22 cistron cistron NN cord-267475-6f4h3cck 819 23 . . . cord-267475-6f4h3cck 819 24 ) ) -RRB- cord-267475-6f4h3cck 820 1 Fragmentation fragmentation NN cord-267475-6f4h3cck 820 2 of of IN cord-267475-6f4h3cck 820 3 the the DT cord-267475-6f4h3cck 820 4 mRNA mrna NN cord-267475-6f4h3cck 820 5 could could MD cord-267475-6f4h3cck 820 6 explain explain VB cord-267475-6f4h3cck 820 7 why why WRB cord-267475-6f4h3cck 820 8 translation translation NN cord-267475-6f4h3cck 820 9 of of IN cord-267475-6f4h3cck 820 10 the the DT cord-267475-6f4h3cck 820 11 3 3 CD cord-267475-6f4h3cck 820 12 0 0 CD cord-267475-6f4h3cck 820 13 eIF4G eif4g CD cord-267475-6f4h3cck 820 14 / / , cord-267475-6f4h3cck 820 15 EGFP EGFP NNP cord-267475-6f4h3cck 820 16 cistron cistron NN cord-267475-6f4h3cck 820 17 persisted persist VBD cord-267475-6f4h3cck 820 18 when when WRB cord-267475-6f4h3cck 820 19 translation translation NN cord-267475-6f4h3cck 820 20 of of IN cord-267475-6f4h3cck 820 21 the the DT cord-267475-6f4h3cck 820 22 5 5 CD cord-267475-6f4h3cck 820 23 0 0 CD cord-267475-6f4h3cck 820 24 cistron cistron NN cord-267475-6f4h3cck 820 25 was be VBD cord-267475-6f4h3cck 820 26 blocked block VBN cord-267475-6f4h3cck 820 27 by by IN cord-267475-6f4h3cck 820 28 a a DT cord-267475-6f4h3cck 820 29 hairpin hairpin JJ cord-267475-6f4h3cck 820 30 structure structure NN cord-267475-6f4h3cck 820 31 ( ( -LRB- cord-267475-6f4h3cck 820 32 Byrd Byrd NNP cord-267475-6f4h3cck 820 33 et et NNP cord-267475-6f4h3cck 820 34 al al NNP cord-267475-6f4h3cck 820 35 . . NNP cord-267475-6f4h3cck 820 36 , , , cord-267475-6f4h3cck 820 37 2002 2002 CD cord-267475-6f4h3cck 820 38 , , , cord-267475-6f4h3cck 820 39 Fig Fig NNP cord-267475-6f4h3cck 820 40 . . . cord-267475-6f4h3cck 820 41 7B 7B NNP cord-267475-6f4h3cck 820 42 ) ) -RRB- cord-267475-6f4h3cck 820 43 . . . cord-267475-6f4h3cck 821 1 The the DT cord-267475-6f4h3cck 821 2 hairpin hairpin NN cord-267475-6f4h3cck 821 3 test test NN cord-267475-6f4h3cck 821 4 , , , cord-267475-6f4h3cck 821 5 widely widely RB cord-267475-6f4h3cck 821 6 used use VBN cord-267475-6f4h3cck 821 7 to to TO cord-267475-6f4h3cck 821 8 test test VB cord-267475-6f4h3cck 821 9 for for IN cord-267475-6f4h3cck 821 10 internal internal JJ cord-267475-6f4h3cck 821 11 initiation initiation NN cord-267475-6f4h3cck 821 12 , , , cord-267475-6f4h3cck 821 13 is be VBZ cord-267475-6f4h3cck 821 14 meaningless meaningless JJ cord-267475-6f4h3cck 821 15 without without IN cord-267475-6f4h3cck 821 16 evidence evidence NN cord-267475-6f4h3cck 821 17 that that IN cord-267475-6f4h3cck 821 18 the the DT cord-267475-6f4h3cck 821 19 dicistronic dicistronic NNP cord-267475-6f4h3cck 821 20 input input NN cord-267475-6f4h3cck 821 21 mRNA mRNA NNP cord-267475-6f4h3cck 821 22 remains remain VBZ cord-267475-6f4h3cck 821 23 intact intact JJ cord-267475-6f4h3cck 821 24 . . . cord-267475-6f4h3cck 822 1 The the DT cord-267475-6f4h3cck 822 2 in in IN cord-267475-6f4h3cck 822 3 vivo vivo NN cord-267475-6f4h3cck 822 4 tests test NNS cord-267475-6f4h3cck 822 5 of of IN cord-267475-6f4h3cck 822 6 eIF4 eIF4 NNP cord-267475-6f4h3cck 822 7 G g NN cord-267475-6f4h3cck 822 8 translation translation NN cord-267475-6f4h3cck 822 9 ( ( -LRB- cord-267475-6f4h3cck 822 10 Byrd Byrd NNP cord-267475-6f4h3cck 822 11 et et NNP cord-267475-6f4h3cck 822 12 al al NNP cord-267475-6f4h3cck 822 13 . . NNP cord-267475-6f4h3cck 822 14 , , , cord-267475-6f4h3cck 822 15 2002 2002 CD cord-267475-6f4h3cck 822 16 , , , cord-267475-6f4h3cck 822 17 Fig Fig NNP cord-267475-6f4h3cck 822 18 . . NNP cord-267475-6f4h3cck 822 19 8 8 CD cord-267475-6f4h3cck 822 20 ) ) -RRB- cord-267475-6f4h3cck 822 21 also also RB cord-267475-6f4h3cck 822 22 require require VBP cord-267475-6f4h3cck 822 23 careful careful JJ cord-267475-6f4h3cck 822 24 RNA RNA NNP cord-267475-6f4h3cck 822 25 analyses analysis NNS cord-267475-6f4h3cck 822 26 to to TO cord-267475-6f4h3cck 822 27 document document VB cord-267475-6f4h3cck 822 28 that that IN cord-267475-6f4h3cck 822 29 the the DT cord-267475-6f4h3cck 822 30 vector vector NN cord-267475-6f4h3cck 822 31 produces produce VBZ cord-267475-6f4h3cck 822 32 only only RB cord-267475-6f4h3cck 822 33 the the DT cord-267475-6f4h3cck 822 34 intended intend VBN cord-267475-6f4h3cck 822 35 dicistronic dicistronic NNP cord-267475-6f4h3cck 822 36 mRNA mRNA NNP cord-267475-6f4h3cck 822 37 ; ; : cord-267475-6f4h3cck 822 38 the the DT cord-267475-6f4h3cck 822 39 quality quality NN cord-267475-6f4h3cck 822 40 of of IN cord-267475-6f4h3cck 822 41 the the DT cord-267475-6f4h3cck 822 42 Northern northern JJ cord-267475-6f4h3cck 822 43 blot blot NN cord-267475-6f4h3cck 822 44 in in IN cord-267475-6f4h3cck 822 45 that that DT cord-267475-6f4h3cck 822 46 figure figure NN cord-267475-6f4h3cck 822 47 falls fall VBZ cord-267475-6f4h3cck 822 48 far far RB cord-267475-6f4h3cck 822 49 short short RB cord-267475-6f4h3cck 822 50 of of IN cord-267475-6f4h3cck 822 51 what what WP cord-267475-6f4h3cck 822 52 is be VBZ cord-267475-6f4h3cck 822 53 required require VBN cord-267475-6f4h3cck 822 54 . . . cord-267475-6f4h3cck 823 1 To to TO cord-267475-6f4h3cck 823 2 rule rule VB cord-267475-6f4h3cck 823 3 out out RP cord-267475-6f4h3cck 823 4 the the DT cord-267475-6f4h3cck 823 5 possibility possibility NN cord-267475-6f4h3cck 823 6 that that IN cord-267475-6f4h3cck 823 7 the the DT cord-267475-6f4h3cck 823 8 3 3 CD cord-267475-6f4h3cck 823 9 0 0 CD cord-267475-6f4h3cck 823 10 cistron cistron NN cord-267475-6f4h3cck 823 11 might may MD cord-267475-6f4h3cck 823 12 be be VB cord-267475-6f4h3cck 823 13 translated translate VBN cord-267475-6f4h3cck 823 14 from from IN cord-267475-6f4h3cck 823 15 an an DT cord-267475-6f4h3cck 823 16 unintended unintended JJ cord-267475-6f4h3cck 823 17 monocistronic monocistronic NN cord-267475-6f4h3cck 823 18 mRNA mRNA NNP cord-267475-6f4h3cck 823 19 , , , cord-267475-6f4h3cck 823 20 a a DT cord-267475-6f4h3cck 823 21 promoter promoter NN cord-267475-6f4h3cck 823 22 - - HYPH cord-267475-6f4h3cck 823 23 deletion deletion NN cord-267475-6f4h3cck 823 24 control control NN cord-267475-6f4h3cck 823 25 is be VBZ cord-267475-6f4h3cck 823 26 needed need VBN cord-267475-6f4h3cck 823 27 -a -a NN cord-267475-6f4h3cck 823 28 control control NN cord-267475-6f4h3cck 823 29 which which WDT cord-267475-6f4h3cck 823 30 shows show VBZ cord-267475-6f4h3cck 823 31 that that IN cord-267475-6f4h3cck 823 32 , , , cord-267475-6f4h3cck 823 33 upon upon IN cord-267475-6f4h3cck 823 34 deleting delete VBG cord-267475-6f4h3cck 823 35 the the DT cord-267475-6f4h3cck 823 36 promoter promoter NN cord-267475-6f4h3cck 823 37 that that WDT cord-267475-6f4h3cck 823 38 precedes precede VBZ cord-267475-6f4h3cck 823 39 the the DT cord-267475-6f4h3cck 823 40 5 5 CD cord-267475-6f4h3cck 823 41 0 0 CD cord-267475-6f4h3cck 823 42 cistron cistron NN cord-267475-6f4h3cck 823 43 , , , cord-267475-6f4h3cck 823 44 expression expression NN cord-267475-6f4h3cck 823 45 of of IN cord-267475-6f4h3cck 823 46 the the DT cord-267475-6f4h3cck 823 47 3 3 CD cord-267475-6f4h3cck 823 48 0 0 CD cord-267475-6f4h3cck 823 49 cistron cistron NN cord-267475-6f4h3cck 823 50 is be VBZ cord-267475-6f4h3cck 823 51 also also RB cord-267475-6f4h3cck 823 52 abolished abolish VBN cord-267475-6f4h3cck 823 53 . . . cord-267475-6f4h3cck 824 1 This this DT cord-267475-6f4h3cck 824 2 test test NN cord-267475-6f4h3cck 824 3 failed fail VBD cord-267475-6f4h3cck 824 4 in in IN cord-267475-6f4h3cck 824 5 studies study NNS cord-267475-6f4h3cck 824 6 with with IN cord-267475-6f4h3cck 824 7 some some DT cord-267475-6f4h3cck 824 8 other other JJ cord-267475-6f4h3cck 824 9 sequences sequence NNS cord-267475-6f4h3cck 824 10 , , , cord-267475-6f4h3cck 824 11 revealing reveal VBG cord-267475-6f4h3cck 824 12 that that IN cord-267475-6f4h3cck 824 13 the the DT cord-267475-6f4h3cck 824 14 candidate candidate NN cord-267475-6f4h3cck 824 15 IRES IRES NNP cord-267475-6f4h3cck 824 16 actually actually RB cord-267475-6f4h3cck 824 17 harbors harbor VBZ cord-267475-6f4h3cck 824 18 a a DT cord-267475-6f4h3cck 824 19 cryptic cryptic JJ cord-267475-6f4h3cck 824 20 promoter promoter NN cord-267475-6f4h3cck 824 21 ( ( -LRB- cord-267475-6f4h3cck 824 22 Han Han NNP cord-267475-6f4h3cck 824 23 and and CC cord-267475-6f4h3cck 824 24 Zhang Zhang NNP cord-267475-6f4h3cck 824 25 , , , cord-267475-6f4h3cck 824 26 2002 2002 CD cord-267475-6f4h3cck 824 27 ; ; : cord-267475-6f4h3cck 825 1 Larsen Larsen NNP cord-267475-6f4h3cck 825 2 et et NNP cord-267475-6f4h3cck 825 3 al al NNP cord-267475-6f4h3cck 825 4 . . NNP cord-267475-6f4h3cck 825 5 , , , cord-267475-6f4h3cck 825 6 2002 2002 CD cord-267475-6f4h3cck 825 7 ) ) -RRB- cord-267475-6f4h3cck 825 8 . . . cord-267475-6f4h3cck 826 1 The the DT cord-267475-6f4h3cck 826 2 foregoing forego VBG cord-267475-6f4h3cck 826 3 discussion discussion NN cord-267475-6f4h3cck 826 4 of of IN cord-267475-6f4h3cck 826 5 eIF4 eIF4 NNP cord-267475-6f4h3cck 826 6 G g NN cord-267475-6f4h3cck 826 7 translation translation NN cord-267475-6f4h3cck 826 8 alludes allude VBZ cord-267475-6f4h3cck 826 9 to to IN cord-267475-6f4h3cck 826 10 only only RB cord-267475-6f4h3cck 826 11 some some DT cord-267475-6f4h3cck 826 12 of of IN cord-267475-6f4h3cck 826 13 the the DT cord-267475-6f4h3cck 826 14 problems problem NNS cord-267475-6f4h3cck 826 15 associated associate VBN cord-267475-6f4h3cck 826 16 with with IN cord-267475-6f4h3cck 826 17 dicistronic dicistronic JJ cord-267475-6f4h3cck 826 18 vectors vector NNS cord-267475-6f4h3cck 826 19 ; ; : cord-267475-6f4h3cck 826 20 a a DT cord-267475-6f4h3cck 826 21 more more RBR cord-267475-6f4h3cck 826 22 detailed detailed JJ cord-267475-6f4h3cck 826 23 critique critique NN cord-267475-6f4h3cck 826 24 may may MD cord-267475-6f4h3cck 826 25 be be VB cord-267475-6f4h3cck 826 26 found find VBN cord-267475-6f4h3cck 826 27 elsewhere elsewhere RB cord-267475-6f4h3cck 827 1 ( ( -LRB- cord-267475-6f4h3cck 827 2 Kozak Kozak NNP cord-267475-6f4h3cck 827 3 , , , cord-267475-6f4h3cck 827 4 2001a 2001a CD cord-267475-6f4h3cck 827 5 ) ) -RRB- cord-267475-6f4h3cck 827 6 . . . cord-267475-6f4h3cck 828 1 Use use NN cord-267475-6f4h3cck 828 2 of of IN cord-267475-6f4h3cck 828 3 a a DT cord-267475-6f4h3cck 828 4 certain certain JJ cord-267475-6f4h3cck 828 5 popular popular JJ cord-267475-6f4h3cck 828 6 vector vector NN cord-267475-6f4h3cck 828 7 which which WDT cord-267475-6f4h3cck 828 8 harbors harbor VBZ cord-267475-6f4h3cck 828 9 an an DT cord-267475-6f4h3cck 828 10 intron intron NN cord-267475-6f4h3cck 828 11 near near IN cord-267475-6f4h3cck 828 12 the the DT cord-267475-6f4h3cck 828 13 5 5 CD cord-267475-6f4h3cck 828 14 0 0 CD cord-267475-6f4h3cck 828 15 end end NN cord-267475-6f4h3cck 828 16 ( ( -LRB- cord-267475-6f4h3cck 828 17 Jopling Jopling NNP cord-267475-6f4h3cck 828 18 and and CC cord-267475-6f4h3cck 828 19 Willis Willis NNP cord-267475-6f4h3cck 828 20 , , , cord-267475-6f4h3cck 828 21 2001 2001 CD cord-267475-6f4h3cck 828 22 ) ) -RRB- cord-267475-6f4h3cck 828 23 increases increase VBZ cord-267475-6f4h3cck 828 24 the the DT cord-267475-6f4h3cck 828 25 likelihood likelihood NN cord-267475-6f4h3cck 828 26 of of IN cord-267475-6f4h3cck 828 27 producing produce VBG cord-267475-6f4h3cck 828 28 an an DT cord-267475-6f4h3cck 828 29 unintended unintended JJ cord-267475-6f4h3cck 828 30 monocistronic monocistronic NN cord-267475-6f4h3cck 828 31 mRNA mrna NN cord-267475-6f4h3cck 828 32 via via IN cord-267475-6f4h3cck 828 33 splicing splicing NN cord-267475-6f4h3cck 828 34 ; ; : cord-267475-6f4h3cck 828 35 the the DT cord-267475-6f4h3cck 828 36 candidate candidate NN cord-267475-6f4h3cck 828 37 IRES IRES NNP cord-267475-6f4h3cck 828 38 need nee MD cord-267475-6f4h3cck 828 39 contribute contribute VB cord-267475-6f4h3cck 828 40 only only RB cord-267475-6f4h3cck 828 41 a a DT cord-267475-6f4h3cck 828 42 cryptic cryptic JJ cord-267475-6f4h3cck 828 43 3 3 CD cord-267475-6f4h3cck 828 44 0 0 CD cord-267475-6f4h3cck 828 45 splice splice NN cord-267475-6f4h3cck 828 46 site site NN cord-267475-6f4h3cck 828 47 . . . cord-267475-6f4h3cck 829 1 This this DT cord-267475-6f4h3cck 829 2 indeed indeed RB cord-267475-6f4h3cck 829 3 happens happen VBZ cord-267475-6f4h3cck 829 4 in in IN cord-267475-6f4h3cck 829 5 some some DT cord-267475-6f4h3cck 829 6 cases case NNS cord-267475-6f4h3cck 829 7 ( ( -LRB- cord-267475-6f4h3cck 829 8 Grundhoff Grundhoff NNP cord-267475-6f4h3cck 829 9 and and CC cord-267475-6f4h3cck 829 10 Ganem Ganem NNP cord-267475-6f4h3cck 829 11 , , , cord-267475-6f4h3cck 829 12 2001 2001 CD cord-267475-6f4h3cck 829 13 ; ; : cord-267475-6f4h3cck 829 14 Pinkstaff Pinkstaff NNP cord-267475-6f4h3cck 829 15 et et FW cord-267475-6f4h3cck 829 16 al al NNP cord-267475-6f4h3cck 829 17 . . NNP cord-267475-6f4h3cck 829 18 , , , cord-267475-6f4h3cck 829 19 2001 2001 CD cord-267475-6f4h3cck 829 20 ) ) -RRB- cord-267475-6f4h3cck 829 21 . . . cord-267475-6f4h3cck 830 1 Claims claim NNS cord-267475-6f4h3cck 830 2 of of IN cord-267475-6f4h3cck 830 3 IRES IRES NNP cord-267475-6f4h3cck 830 4 activity activity NN cord-267475-6f4h3cck 830 5 are be VBP cord-267475-6f4h3cck 830 6 problematic problematic JJ cord-267475-6f4h3cck 830 7 when when WRB cord-267475-6f4h3cck 830 8 supported support VBN cord-267475-6f4h3cck 830 9 by by IN cord-267475-6f4h3cck 830 10 in in FW cord-267475-6f4h3cck 830 11 vitro vitro FW cord-267475-6f4h3cck 830 12 assays assay NNS cord-267475-6f4h3cck 830 13 in in IN cord-267475-6f4h3cck 830 14 which which WDT cord-267475-6f4h3cck 830 15 translation translation NN cord-267475-6f4h3cck 830 16 of of IN cord-267475-6f4h3cck 830 17 the the DT cord-267475-6f4h3cck 830 18 3 3 CD cord-267475-6f4h3cck 830 19 0 0 CD cord-267475-6f4h3cck 830 20 ORF ORF NNP cord-267475-6f4h3cck 830 21 is be VBZ cord-267475-6f4h3cck 830 22 very very RB cord-267475-6f4h3cck 830 23 , , , cord-267475-6f4h3cck 830 24 very very RB cord-267475-6f4h3cck 830 25 weak weak JJ cord-267475-6f4h3cck 830 26 ( ( -LRB- cord-267475-6f4h3cck 830 27 e.g. e.g. IN cord-267475-6f4h3cck 830 28 Deffaud Deffaud NNP cord-267475-6f4h3cck 830 29 and and CC cord-267475-6f4h3cck 830 30 Darlix Darlix NNP cord-267475-6f4h3cck 830 31 , , , cord-267475-6f4h3cck 830 32 2000 2000 CD cord-267475-6f4h3cck 830 33 , , , cord-267475-6f4h3cck 830 34 Fig Fig NNP cord-267475-6f4h3cck 830 35 . . . cord-267475-6f4h3cck 831 1 2 2 LS cord-267475-6f4h3cck 831 2 ; ; : cord-267475-6f4h3cck 831 3 Lekven Lekven NNP cord-267475-6f4h3cck 831 4 et et NNP cord-267475-6f4h3cck 831 5 al al NNP cord-267475-6f4h3cck 831 6 . . NNP cord-267475-6f4h3cck 831 7 , , , cord-267475-6f4h3cck 831 8 2001 2001 CD cord-267475-6f4h3cck 832 1 , , , cord-267475-6f4h3cck 832 2 Fig Fig NNP cord-267475-6f4h3cck 832 3 . . NNP cord-267475-6f4h3cck 832 4 3B 3B NNP cord-267475-6f4h3cck 832 5 , , , cord-267475-6f4h3cck 832 6 lane lane NN cord-267475-6f4h3cck 832 7 3 3 CD cord-267475-6f4h3cck 832 8 ; ; : cord-267475-6f4h3cck 832 9 Maser Maser NNP cord-267475-6f4h3cck 832 10 et et NNP cord-267475-6f4h3cck 832 11 al al NNP cord-267475-6f4h3cck 832 12 . . NNP cord-267475-6f4h3cck 832 13 , , , cord-267475-6f4h3cck 832 14 2001 2001 CD cord-267475-6f4h3cck 832 15 , , , cord-267475-6f4h3cck 832 16 Fig Fig NNP cord-267475-6f4h3cck 832 17 . . NNP cord-267475-6f4h3cck 832 18 4e 4e LS cord-267475-6f4h3cck 832 19 ) ) -RRB- cord-267475-6f4h3cck 832 20 . . . cord-267475-6f4h3cck 833 1 The the DT cord-267475-6f4h3cck 833 2 simple simple JJ cord-267475-6f4h3cck 833 3 idea idea NN cord-267475-6f4h3cck 833 4 that that IN cord-267475-6f4h3cck 833 5 an an DT cord-267475-6f4h3cck 833 6 IRES IRES NNP cord-267475-6f4h3cck 833 7 can can MD cord-267475-6f4h3cck 833 8 be be VB cord-267475-6f4h3cck 833 9 identified identify VBN cord-267475-6f4h3cck 833 10 based base VBN cord-267475-6f4h3cck 833 11 on on IN cord-267475-6f4h3cck 833 12 the the DT cord-267475-6f4h3cck 833 13 ability ability NN cord-267475-6f4h3cck 833 14 to to TO cord-267475-6f4h3cck 833 15 support support VB cord-267475-6f4h3cck 833 16 translation translation NN cord-267475-6f4h3cck 833 17 of of IN cord-267475-6f4h3cck 833 18 a a DT cord-267475-6f4h3cck 833 19 3 3 CD cord-267475-6f4h3cck 833 20 0 0 CD cord-267475-6f4h3cck 833 21 cistron cistron NN cord-267475-6f4h3cck 833 22 runs run VBZ cord-267475-6f4h3cck 833 23 into into IN cord-267475-6f4h3cck 833 24 trouble trouble NN cord-267475-6f4h3cck 833 25 when when WRB cord-267475-6f4h3cck 833 26 , , , cord-267475-6f4h3cck 833 27 for for IN cord-267475-6f4h3cck 833 28 example example NN cord-267475-6f4h3cck 833 29 , , , cord-267475-6f4h3cck 833 30 the the DT cord-267475-6f4h3cck 833 31 bglobin bglobin NNP cord-267475-6f4h3cck 833 32 mRNA mRNA NNP cord-267475-6f4h3cck 833 33 leader leader NN cord-267475-6f4h3cck 833 34 sequence sequence NN cord-267475-6f4h3cck 833 35 , , , cord-267475-6f4h3cck 833 36 intended intend VBN cord-267475-6f4h3cck 833 37 to to TO cord-267475-6f4h3cck 833 38 serve serve VB cord-267475-6f4h3cck 833 39 as as IN cord-267475-6f4h3cck 833 40 a a DT cord-267475-6f4h3cck 833 41 negative negative JJ cord-267475-6f4h3cck 833 42 control control NN cord-267475-6f4h3cck 833 43 , , , cord-267475-6f4h3cck 833 44 turns turn VBZ cord-267475-6f4h3cck 833 45 out out RP cord-267475-6f4h3cck 833 46 somehow somehow RB cord-267475-6f4h3cck 833 47 to to TO cord-267475-6f4h3cck 833 48 allow allow VB cord-267475-6f4h3cck 833 49 translation translation NN cord-267475-6f4h3cck 833 50 of of IN cord-267475-6f4h3cck 833 51 a a DT cord-267475-6f4h3cck 833 52 downstream downstream JJ cord-267475-6f4h3cck 833 53 cistron cistron NN cord-267475-6f4h3cck 833 54 ( ( -LRB- cord-267475-6f4h3cck 833 55 Van Van NNP cord-267475-6f4h3cck 833 56 der der NNP cord-267475-6f4h3cck 833 57 Velden Velden NNP cord-267475-6f4h3cck 833 58 et et FW cord-267475-6f4h3cck 833 59 al al NNP cord-267475-6f4h3cck 833 60 . . NNP cord-267475-6f4h3cck 833 61 , , , cord-267475-6f4h3cck 833 62 2002 2002 CD cord-267475-6f4h3cck 833 63 ) ) -RRB- cord-267475-6f4h3cck 833 64 . . . cord-267475-6f4h3cck 834 1 In in IN cord-267475-6f4h3cck 834 2 another another DT cord-267475-6f4h3cck 834 3 study study NN cord-267475-6f4h3cck 834 4 , , , cord-267475-6f4h3cck 834 5 merely merely RB cord-267475-6f4h3cck 834 6 lengthening lengthen VBG cord-267475-6f4h3cck 834 7 the the DT cord-267475-6f4h3cck 834 8 intercistronic intercistronic NNP cord-267475-6f4h3cck 834 9 domain domain NN cord-267475-6f4h3cck 834 10 enabled enable VBD cord-267475-6f4h3cck 834 11 substantial substantial JJ cord-267475-6f4h3cck 834 12 translation translation NN cord-267475-6f4h3cck 834 13 of of IN cord-267475-6f4h3cck 834 14 the the DT cord-267475-6f4h3cck 834 15 3 3 CD cord-267475-6f4h3cck 834 16 0 0 CD cord-267475-6f4h3cck 834 17 cistron cistron NN cord-267475-6f4h3cck 834 18 ( ( -LRB- cord-267475-6f4h3cck 834 19 Gallie Gallie NNP cord-267475-6f4h3cck 834 20 et et FW cord-267475-6f4h3cck 834 21 al al NNP cord-267475-6f4h3cck 834 22 . . NNP cord-267475-6f4h3cck 834 23 , , , cord-267475-6f4h3cck 834 24 2000 2000 CD cord-267475-6f4h3cck 834 25 ) ) -RRB- cord-267475-6f4h3cck 834 26 , , , cord-267475-6f4h3cck 834 27 perhaps perhaps RB cord-267475-6f4h3cck 834 28 by by IN cord-267475-6f4h3cck 834 29 providing provide VBG cord-267475-6f4h3cck 834 30 room room NN cord-267475-6f4h3cck 834 31 for for IN cord-267475-6f4h3cck 834 32 RNases rnase NNS cord-267475-6f4h3cck 834 33 to to TO cord-267475-6f4h3cck 834 34 cleave cleave VB cord-267475-6f4h3cck 834 35 and and CC cord-267475-6f4h3cck 834 36 thus thus RB cord-267475-6f4h3cck 834 37 release release VB cord-267475-6f4h3cck 834 38 a a DT cord-267475-6f4h3cck 834 39 translatable translatable JJ cord-267475-6f4h3cck 834 40 3 3 CD cord-267475-6f4h3cck 834 41 0 0 CD cord-267475-6f4h3cck 834 42 fragment fragment NN cord-267475-6f4h3cck 834 43 . . . cord-267475-6f4h3cck 835 1 Even even RB cord-267475-6f4h3cck 835 2 with with IN cord-267475-6f4h3cck 835 3 the the DT cord-267475-6f4h3cck 835 4 paradigmatic paradigmatic JJ cord-267475-6f4h3cck 835 5 IRES IRES NNP cord-267475-6f4h3cck 835 6 elements element NNS cord-267475-6f4h3cck 835 7 derived derive VBN cord-267475-6f4h3cck 835 8 from from IN cord-267475-6f4h3cck 835 9 picornaviruses picornavirus NNS cord-267475-6f4h3cck 835 10 , , , cord-267475-6f4h3cck 835 11 the the DT cord-267475-6f4h3cck 835 12 ability ability NN cord-267475-6f4h3cck 835 13 to to TO cord-267475-6f4h3cck 835 14 support support VB cord-267475-6f4h3cck 835 15 internal internal JJ cord-267475-6f4h3cck 835 16 initiation initiation NN cord-267475-6f4h3cck 835 17 was be VBD cord-267475-6f4h3cck 835 18 found find VBN cord-267475-6f4h3cck 835 19 to to TO cord-267475-6f4h3cck 835 20 depend depend VB cord-267475-6f4h3cck 835 21 inexplicably inexplicably RB cord-267475-6f4h3cck 835 22 on on IN cord-267475-6f4h3cck 835 23 the the DT cord-267475-6f4h3cck 835 24 choice choice NN cord-267475-6f4h3cck 835 25 and and CC cord-267475-6f4h3cck 835 26 arrangement arrangement NN cord-267475-6f4h3cck 835 27 of of IN cord-267475-6f4h3cck 835 28 5 5 CD cord-267475-6f4h3cck 835 29 0 0 CD cord-267475-6f4h3cck 835 30 and and CC cord-267475-6f4h3cck 835 31 3 3 CD cord-267475-6f4h3cck 835 32 0 0 CD cord-267475-6f4h3cck 835 33 reporter reporter NN cord-267475-6f4h3cck 835 34 genes gene NNS cord-267475-6f4h3cck 835 35 ( ( -LRB- cord-267475-6f4h3cck 835 36 Hennecke Hennecke NNP cord-267475-6f4h3cck 835 37 et et FW cord-267475-6f4h3cck 835 38 al al NNP cord-267475-6f4h3cck 835 39 . . NNP cord-267475-6f4h3cck 835 40 , , , cord-267475-6f4h3cck 835 41 2001 2001 CD cord-267475-6f4h3cck 835 42 ) ) -RRB- cord-267475-6f4h3cck 835 43 . . . cord-267475-6f4h3cck 836 1 These these DT cord-267475-6f4h3cck 836 2 odditiesalong odditiesalong NN cord-267475-6f4h3cck 836 3 with with IN cord-267475-6f4h3cck 836 4 the the DT cord-267475-6f4h3cck 836 5 notable notable JJ cord-267475-6f4h3cck 836 6 inability inability NN cord-267475-6f4h3cck 836 7 to to TO cord-267475-6f4h3cck 836 8 translate translate VB cord-267475-6f4h3cck 836 9 the the DT cord-267475-6f4h3cck 836 10 3 3 CD cord-267475-6f4h3cck 836 11 0 0 CD cord-267475-6f4h3cck 836 12 cistron cistron NN cord-267475-6f4h3cck 836 13 in in IN cord-267475-6f4h3cck 836 14 natural natural JJ cord-267475-6f4h3cck 836 15 dicistronic dicistronic NNP cord-267475-6f4h3cck 836 16 mRNAs mRNAs . cord-267475-6f4h3cck 837 1 ( ( -LRB- cord-267475-6f4h3cck 837 2 Table table NN cord-267475-6f4h3cck 837 3 1 1 CD cord-267475-6f4h3cck 837 4 ) ) -RRB- cord-267475-6f4h3cck 838 1 -are -are : cord-267475-6f4h3cck 838 2 reason reason NN cord-267475-6f4h3cck 838 3 to to TO cord-267475-6f4h3cck 838 4 worry worry VB cord-267475-6f4h3cck 838 5 about about IN cord-267475-6f4h3cck 838 6 the the DT cord-267475-6f4h3cck 838 7 validity validity NN cord-267475-6f4h3cck 838 8 of of IN cord-267475-6f4h3cck 838 9 experiments experiment NNS cord-267475-6f4h3cck 838 10 that that WDT cord-267475-6f4h3cck 838 11 employ employ VBP cord-267475-6f4h3cck 838 12 synthetic synthetic JJ cord-267475-6f4h3cck 838 13 dicistronic dicistronic JJ cord-267475-6f4h3cck 838 14 constructs construct NNS cord-267475-6f4h3cck 838 15 . . . cord-267475-6f4h3cck 839 1 The the DT cord-267475-6f4h3cck 839 2 proffered proffer VBN cord-267475-6f4h3cck 839 3 rationale rationale NN cord-267475-6f4h3cck 839 4 for for IN cord-267475-6f4h3cck 839 5 a a DT cord-267475-6f4h3cck 839 6 cap cap NN cord-267475-6f4h3cck 839 7 - - HYPH cord-267475-6f4h3cck 839 8 independent independent JJ cord-267475-6f4h3cck 839 9 internal internal JJ cord-267475-6f4h3cck 839 10 initiation initiation NN cord-267475-6f4h3cck 839 11 mechanism mechanism NN cord-267475-6f4h3cck 839 12 is be VBZ cord-267475-6f4h3cck 839 13 that that IN cord-267475-6f4h3cck 839 14 it -PRON- PRP cord-267475-6f4h3cck 839 15 would would MD cord-267475-6f4h3cck 839 16 enable enable VB cord-267475-6f4h3cck 839 17 certain certain JJ cord-267475-6f4h3cck 839 18 mRNAs mrnas PRP cord-267475-6f4h3cck 839 19 to to TO cord-267475-6f4h3cck 839 20 be be VB cord-267475-6f4h3cck 839 21 translated translate VBN cord-267475-6f4h3cck 839 22 when when WRB cord-267475-6f4h3cck 839 23 eIF4E eif4e CD cord-267475-6f4h3cck 839 24 levels level NNS cord-267475-6f4h3cck 839 25 decline decline VBP cord-267475-6f4h3cck 839 26 , , , cord-267475-6f4h3cck 839 27 but but CC cord-267475-6f4h3cck 839 28 recent recent JJ cord-267475-6f4h3cck 839 29 experiments experiment NNS cord-267475-6f4h3cck 839 30 presented present VBN cord-267475-6f4h3cck 839 31 in in IN cord-267475-6f4h3cck 839 32 support support NN cord-267475-6f4h3cck 839 33 of of IN cord-267475-6f4h3cck 839 34 that that DT cord-267475-6f4h3cck 839 35 idea idea NN cord-267475-6f4h3cck 839 36 used use VBD cord-267475-6f4h3cck 839 37 the the DT cord-267475-6f4h3cck 839 38 5 5 CD cord-267475-6f4h3cck 839 39 0 0 CD cord-267475-6f4h3cck 839 40 UTR UTR NNP cord-267475-6f4h3cck 839 41 from from IN cord-267475-6f4h3cck 839 42 poliovirus poliovirus NN cord-267475-6f4h3cck 839 43 rather rather RB cord-267475-6f4h3cck 839 44 than than IN cord-267475-6f4h3cck 839 45 5 5 CD cord-267475-6f4h3cck 839 46 0 0 CD cord-267475-6f4h3cck 839 47 UTRs utr NNS cord-267475-6f4h3cck 839 48 from from IN cord-267475-6f4h3cck 839 49 cellular cellular JJ cord-267475-6f4h3cck 839 50 mRNAs mrna NNS cord-267475-6f4h3cck 839 51 , , , cord-267475-6f4h3cck 839 52 such such JJ cord-267475-6f4h3cck 839 53 as as IN cord-267475-6f4h3cck 839 54 eIF4 eIF4 NNP cord-267475-6f4h3cck 839 55 G G NNP cord-267475-6f4h3cck 839 56 , , , cord-267475-6f4h3cck 839 57 that that WDT cord-267475-6f4h3cck 839 58 are be VBP cord-267475-6f4h3cck 839 59 supposedly supposedly RB cord-267475-6f4h3cck 839 60 regulated regulate VBN cord-267475-6f4h3cck 839 61 via via IN cord-267475-6f4h3cck 839 62 ' ' '' cord-267475-6f4h3cck 839 63 a a DT cord-267475-6f4h3cck 839 64 dynamic dynamic JJ cord-267475-6f4h3cck 839 65 interplay interplay NN cord-267475-6f4h3cck 839 66 between between IN cord-267475-6f4h3cck 839 67 cap cap NN cord-267475-6f4h3cck 839 68 - - HYPH cord-267475-6f4h3cck 839 69 dependent dependent JJ cord-267475-6f4h3cck 839 70 and and CC cord-267475-6f4h3cck 839 71 cap cap NN cord-267475-6f4h3cck 839 72 - - HYPH cord-267475-6f4h3cck 839 73 independent independent JJ cord-267475-6f4h3cck 839 74 processes process NNS cord-267475-6f4h3cck 839 75 ' ' '' cord-267475-6f4h3cck 839 76 . . . cord-267475-6f4h3cck 840 1 Even even RB cord-267475-6f4h3cck 840 2 if if IN cord-267475-6f4h3cck 840 3 the the DT cord-267475-6f4h3cck 840 4 proffered proffer VBN cord-267475-6f4h3cck 840 5 rationale rationale NN cord-267475-6f4h3cck 840 6 is be VBZ cord-267475-6f4h3cck 840 7 valid valid JJ cord-267475-6f4h3cck 840 8 , , , cord-267475-6f4h3cck 840 9 convincing convincing JJ cord-267475-6f4h3cck 840 10 evidence evidence NN cord-267475-6f4h3cck 840 11 for for IN cord-267475-6f4h3cck 840 12 direct direct JJ cord-267475-6f4h3cck 840 13 internal internal JJ cord-267475-6f4h3cck 840 14 initiation initiation NN cord-267475-6f4h3cck 840 15 with with IN cord-267475-6f4h3cck 840 16 particular particular JJ cord-267475-6f4h3cck 840 17 mRNAs mrnas CD cord-267475-6f4h3cck 840 18 is be VBZ cord-267475-6f4h3cck 840 19 needed need VBN cord-267475-6f4h3cck 840 20 . . . cord-267475-6f4h3cck 841 1 The the DT cord-267475-6f4h3cck 841 2 widely widely RB cord-267475-6f4h3cck 841 3 used use VBN cord-267475-6f4h3cck 841 4 dicistronic dicistronic JJ cord-267475-6f4h3cck 841 5 assay assay NN cord-267475-6f4h3cck 841 6 has have VBZ cord-267475-6f4h3cck 841 7 flaws flaw NNS cord-267475-6f4h3cck 841 8 , , , cord-267475-6f4h3cck 841 9 as as IN cord-267475-6f4h3cck 841 10 outlined outline VBN cord-267475-6f4h3cck 841 11 above above RB cord-267475-6f4h3cck 841 12 . . . cord-267475-6f4h3cck 842 1 An an DT cord-267475-6f4h3cck 842 2 alternative alternative JJ cord-267475-6f4h3cck 842 3 assay assay NN cord-267475-6f4h3cck 842 4 which which WDT cord-267475-6f4h3cck 842 5 involves involve VBZ cord-267475-6f4h3cck 842 6 circularization circularization NN cord-267475-6f4h3cck 842 7 of of IN cord-267475-6f4h3cck 842 8 the the DT cord-267475-6f4h3cck 842 9 mRNA mrna NN cord-267475-6f4h3cck 842 10 has have VBZ cord-267475-6f4h3cck 842 11 been be VBN cord-267475-6f4h3cck 842 12 attempted attempt VBN cord-267475-6f4h3cck 842 13 with with IN cord-267475-6f4h3cck 842 14 only only RB cord-267475-6f4h3cck 842 15 one one CD cord-267475-6f4h3cck 842 16 viral viral JJ cord-267475-6f4h3cck 842 17 IRES ires JJ cord-267475-6f4h3cck 842 18 element element NN cord-267475-6f4h3cck 842 19 ( ( -LRB- cord-267475-6f4h3cck 842 20 Chen Chen NNP cord-267475-6f4h3cck 842 21 and and CC cord-267475-6f4h3cck 842 22 Sarnow Sarnow NNP cord-267475-6f4h3cck 842 23 , , , cord-267475-6f4h3cck 842 24 1995 1995 CD cord-267475-6f4h3cck 842 25 ) ) -RRB- cord-267475-6f4h3cck 842 26 ; ; : cord-267475-6f4h3cck 842 27 the the DT cord-267475-6f4h3cck 842 28 results result NNS cord-267475-6f4h3cck 842 29 await await VBP cord-267475-6f4h3cck 842 30 independent independent JJ cord-267475-6f4h3cck 842 31 verification verification NN cord-267475-6f4h3cck 842 32 and and CC cord-267475-6f4h3cck 842 33 extension extension NN cord-267475-6f4h3cck 842 34 to to IN cord-267475-6f4h3cck 842 35 other other JJ cord-267475-6f4h3cck 842 36 sequences sequence NNS cord-267475-6f4h3cck 842 37 . . . cord-267475-6f4h3cck 843 1 The the DT cord-267475-6f4h3cck 843 2 scanning scanning NN cord-267475-6f4h3cck 843 3 model model NN cord-267475-6f4h3cck 843 4 provides provide VBZ cord-267475-6f4h3cck 843 5 a a DT cord-267475-6f4h3cck 843 6 framework framework NN cord-267475-6f4h3cck 843 7 for for IN cord-267475-6f4h3cck 843 8 understanding understand VBG cord-267475-6f4h3cck 843 9 basic basic JJ cord-267475-6f4h3cck 843 10 patterns pattern NNS cord-267475-6f4h3cck 843 11 of of IN cord-267475-6f4h3cck 843 12 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 843 13 gene gene NN cord-267475-6f4h3cck 843 14 expression expression NN cord-267475-6f4h3cck 843 15 , , , cord-267475-6f4h3cck 843 16 such such JJ cord-267475-6f4h3cck 843 17 as as IN cord-267475-6f4h3cck 843 18 the the DT cord-267475-6f4h3cck 843 19 reliance reliance NN cord-267475-6f4h3cck 843 20 on on IN cord-267475-6f4h3cck 843 21 monocistronic monocistronic NNP cord-267475-6f4h3cck 843 22 mRNAs mRNAs NNP cord-267475-6f4h3cck 843 23 , , , cord-267475-6f4h3cck 843 24 and and CC cord-267475-6f4h3cck 843 25 for for IN cord-267475-6f4h3cck 843 26 understanding understand VBG cord-267475-6f4h3cck 843 27 how how WRB cord-267475-6f4h3cck 843 28 translation translation NN cord-267475-6f4h3cck 843 29 is be VBZ cord-267475-6f4h3cck 843 30 perturbed perturb VBN cord-267475-6f4h3cck 843 31 by by IN cord-267475-6f4h3cck 843 32 mutations mutation NNS cord-267475-6f4h3cck 843 33 that that WDT cord-267475-6f4h3cck 843 34 restructure restructure VBP cord-267475-6f4h3cck 843 35 the the DT cord-267475-6f4h3cck 843 36 5 5 CD cord-267475-6f4h3cck 843 37 0 0 CD cord-267475-6f4h3cck 843 38 UTR UTR NNP cord-267475-6f4h3cck 843 39 . . . cord-267475-6f4h3cck 844 1 A a DT cord-267475-6f4h3cck 844 2 growing grow VBG cord-267475-6f4h3cck 844 3 number number NN cord-267475-6f4h3cck 844 4 of of IN cord-267475-6f4h3cck 844 5 human human JJ cord-267475-6f4h3cck 844 6 diseases disease NNS cord-267475-6f4h3cck 844 7 have have VBP cord-267475-6f4h3cck 844 8 been be VBN cord-267475-6f4h3cck 844 9 traced trace VBN cord-267475-6f4h3cck 844 10 to to IN cord-267475-6f4h3cck 844 11 such such JJ cord-267475-6f4h3cck 844 12 mutations mutation NNS cord-267475-6f4h3cck 844 13 . . . cord-267475-6f4h3cck 845 1 The the DT cord-267475-6f4h3cck 845 2 scanning scanning NN cord-267475-6f4h3cck 845 3 mechanism mechanism NN cord-267475-6f4h3cck 845 4 has have VBZ cord-267475-6f4h3cck 845 5 been be VBN cord-267475-6f4h3cck 845 6 shown show VBN cord-267475-6f4h3cck 845 7 to to TO cord-267475-6f4h3cck 845 8 operate operate VB cord-267475-6f4h3cck 845 9 not not RB cord-267475-6f4h3cck 845 10 only only RB cord-267475-6f4h3cck 845 11 with with IN cord-267475-6f4h3cck 845 12 simple simple JJ cord-267475-6f4h3cck 845 13 mRNAs mRNAs NNPS cord-267475-6f4h3cck 845 14 that that WDT cord-267475-6f4h3cck 845 15 have have VBP cord-267475-6f4h3cck 845 16 a a DT cord-267475-6f4h3cck 845 17 short short JJ cord-267475-6f4h3cck 845 18 5 5 CD cord-267475-6f4h3cck 845 19 0 0 CD cord-267475-6f4h3cck 845 20 UTR UTR NNP cord-267475-6f4h3cck 845 21 and and CC cord-267475-6f4h3cck 845 22 initiate initiate VB cord-267475-6f4h3cck 845 23 at at IN cord-267475-6f4h3cck 845 24 the the DT cord-267475-6f4h3cck 845 25 first first JJ cord-267475-6f4h3cck 845 26 AUG AUG NNP cord-267475-6f4h3cck 845 27 codon codon NN cord-267475-6f4h3cck 845 28 , , , cord-267475-6f4h3cck 845 29 but but CC cord-267475-6f4h3cck 845 30 also also RB cord-267475-6f4h3cck 846 1 with with IN cord-267475-6f4h3cck 846 2 mRNAs mrna NNS cord-267475-6f4h3cck 847 1 that that WDT cord-267475-6f4h3cck 847 2 have have VBP cord-267475-6f4h3cck 847 3 complicated complicate VBN cord-267475-6f4h3cck 847 4 leader leader NN cord-267475-6f4h3cck 847 5 sequences sequence NNS cord-267475-6f4h3cck 847 6 and and CC cord-267475-6f4h3cck 847 7 multiple multiple JJ cord-267475-6f4h3cck 847 8 start start NN cord-267475-6f4h3cck 847 9 codons codon NNS cord-267475-6f4h3cck 847 10 . . . cord-267475-6f4h3cck 848 1 One one CD cord-267475-6f4h3cck 848 2 often often RB cord-267475-6f4h3cck 848 3 hears hear VBZ cord-267475-6f4h3cck 848 4 the the DT cord-267475-6f4h3cck 848 5 suggestion suggestion NN cord-267475-6f4h3cck 848 6 that that IN cord-267475-6f4h3cck 848 7 an an DT cord-267475-6f4h3cck 848 8 alternative alternative NN cord-267475-6f4h3cck 848 9 , , , cord-267475-6f4h3cck 848 10 IRESmediated iresmediated JJ cord-267475-6f4h3cck 848 11 mechanism mechanism NN cord-267475-6f4h3cck 848 12 of of IN cord-267475-6f4h3cck 848 13 initiation initiation NN cord-267475-6f4h3cck 848 14 is be VBZ cord-267475-6f4h3cck 848 15 required require VBN cord-267475-6f4h3cck 848 16 when when WRB cord-267475-6f4h3cck 848 17 a a DT cord-267475-6f4h3cck 848 18 long long JJ cord-267475-6f4h3cck 848 19 leader leader NN cord-267475-6f4h3cck 848 20 sequence sequence NN cord-267475-6f4h3cck 848 21 is be VBZ cord-267475-6f4h3cck 848 22 encumbered encumber VBN cord-267475-6f4h3cck 848 23 by by IN cord-267475-6f4h3cck 848 24 secondary secondary JJ cord-267475-6f4h3cck 848 25 structure structure NN cord-267475-6f4h3cck 848 26 or or CC cord-267475-6f4h3cck 848 27 upstream upstream JJ cord-267475-6f4h3cck 848 28 AUG AUG NNP cord-267475-6f4h3cck 848 29 codons codon NNS cord-267475-6f4h3cck 848 30 ( ( -LRB- cord-267475-6f4h3cck 848 31 Dever Dever NNP cord-267475-6f4h3cck 848 32 , , , cord-267475-6f4h3cck 848 33 2002 2002 CD cord-267475-6f4h3cck 848 34 ; ; : cord-267475-6f4h3cck 849 1 Pestova Pestova NNP cord-267475-6f4h3cck 849 2 et et NNP cord-267475-6f4h3cck 849 3 al al NNP cord-267475-6f4h3cck 849 4 . . NNP cord-267475-6f4h3cck 849 5 , , , cord-267475-6f4h3cck 849 6 2001 2001 CD cord-267475-6f4h3cck 849 7 ) ) -RRB- cord-267475-6f4h3cck 849 8 . . . cord-267475-6f4h3cck 850 1 That that DT cord-267475-6f4h3cck 850 2 view view NN cord-267475-6f4h3cck 850 3 is be VBZ cord-267475-6f4h3cck 850 4 not not RB cord-267475-6f4h3cck 850 5 well well RB cord-267475-6f4h3cck 850 6 taken take VBN cord-267475-6f4h3cck 850 7 . . . cord-267475-6f4h3cck 851 1 Scanning scanning NN cord-267475-6f4h3cck 851 2 can can MD cord-267475-6f4h3cck 851 3 occur occur VB cord-267475-6f4h3cck 851 4 over over IN cord-267475-6f4h3cck 851 5 long long JJ cord-267475-6f4h3cck 851 6 distances distance NNS cord-267475-6f4h3cck 851 7 , , , cord-267475-6f4h3cck 851 8 as as IN cord-267475-6f4h3cck 851 9 evidenced evidence VBN cord-267475-6f4h3cck 851 10 by by IN cord-267475-6f4h3cck 851 11 some some DT cord-267475-6f4h3cck 851 12 bifunctional bifunctional JJ cord-267475-6f4h3cck 851 13 viral viral NN cord-267475-6f4h3cck 851 14 mRNAs mRNAs -RRB- cord-267475-6f4h3cck 851 15 in in IN cord-267475-6f4h3cck 851 16 which which WDT cord-267475-6f4h3cck 851 17 the the DT cord-267475-6f4h3cck 851 18 second second JJ cord-267475-6f4h3cck 851 19 start start NN cord-267475-6f4h3cck 851 20 site site NN cord-267475-6f4h3cck 851 21 is be VBZ cord-267475-6f4h3cck 851 22 more more JJR cord-267475-6f4h3cck 851 23 than than IN cord-267475-6f4h3cck 851 24 500 500 CD cord-267475-6f4h3cck 851 25 nt nt RB cord-267475-6f4h3cck 851 26 downstream downstream RB cord-267475-6f4h3cck 851 27 from from IN cord-267475-6f4h3cck 851 28 the the DT cord-267475-6f4h3cck 851 29 first first JJ cord-267475-6f4h3cck 851 30 ( ( -LRB- cord-267475-6f4h3cck 851 31 e.g. e.g. RB cord-267475-6f4h3cck 851 32 peanut peanut NN cord-267475-6f4h3cck 851 33 clump clump NN cord-267475-6f4h3cck 851 34 virus virus NN cord-267475-6f4h3cck 851 35 , , , cord-267475-6f4h3cck 851 36 southern southern JJ cord-267475-6f4h3cck 851 37 bean bean NN cord-267475-6f4h3cck 851 38 mosaic mosaic NNP cord-267475-6f4h3cck 851 39 virus virus NN cord-267475-6f4h3cck 851 40 , , , cord-267475-6f4h3cck 851 41 rice rice NN cord-267475-6f4h3cck 851 42 tungro tungro NNP cord-267475-6f4h3cck 851 43 bacilliform bacilliform NNP cord-267475-6f4h3cck 851 44 virus virus NN cord-267475-6f4h3cck 851 45 ; ; : cord-267475-6f4h3cck 851 46 Table Table NNP cord-267475-6f4h3cck 851 47 3 3 CD cord-267475-6f4h3cck 851 48 and and CC cord-267475-6f4h3cck 851 49 Fig Fig NNP cord-267475-6f4h3cck 851 50 . . . cord-267475-6f4h3cck 851 51 1C 1C NNP cord-267475-6f4h3cck 851 52 ) ) -RRB- cord-267475-6f4h3cck 851 53 . . . cord-267475-6f4h3cck 852 1 The the DT cord-267475-6f4h3cck 852 2 structure structure NN cord-267475-6f4h3cck 852 3 - - HYPH cord-267475-6f4h3cck 852 4 prone prone JJ cord-267475-6f4h3cck 852 5 , , , cord-267475-6f4h3cck 852 6 GC gc NN cord-267475-6f4h3cck 852 7 - - HYPH cord-267475-6f4h3cck 852 8 rich rich JJ cord-267475-6f4h3cck 852 9 leader leader NN cord-267475-6f4h3cck 852 10 sequences sequence NNS cord-267475-6f4h3cck 852 11 on on IN cord-267475-6f4h3cck 852 12 mammalian mammalian JJ cord-267475-6f4h3cck 852 13 mRNAs mrnas CD cord-267475-6f4h3cck 852 14 strongly strongly RB cord-267475-6f4h3cck 852 15 reduce reduce VB cord-267475-6f4h3cck 852 16 translational translational JJ cord-267475-6f4h3cck 852 17 efficiency efficiency NN cord-267475-6f4h3cck 852 18 but but CC cord-267475-6f4h3cck 852 19 do do VBP cord-267475-6f4h3cck 852 20 not not RB cord-267475-6f4h3cck 852 21 preclude preclude VB cord-267475-6f4h3cck 852 22 operation operation NN cord-267475-6f4h3cck 852 23 of of IN cord-267475-6f4h3cck 852 24 the the DT cord-267475-6f4h3cck 852 25 scanning scanning NN cord-267475-6f4h3cck 852 26 mechanism mechanism NN cord-267475-6f4h3cck 852 27 ( ( -LRB- cord-267475-6f4h3cck 852 28 Van Van NNP cord-267475-6f4h3cck 852 29 der der NNP cord-267475-6f4h3cck 852 30 Velden Velden NNP cord-267475-6f4h3cck 852 31 et et FW cord-267475-6f4h3cck 852 32 al al NNP cord-267475-6f4h3cck 852 33 . . NNP cord-267475-6f4h3cck 852 34 , , , cord-267475-6f4h3cck 852 35 2002 2002 CD cord-267475-6f4h3cck 852 36 ) ) -RRB- cord-267475-6f4h3cck 852 37 . . . cord-267475-6f4h3cck 853 1 Upstream Upstream NNP cord-267475-6f4h3cck 853 2 AUG AUG NNP cord-267475-6f4h3cck 853 3 codons codon NNS cord-267475-6f4h3cck 853 4 also also RB cord-267475-6f4h3cck 853 5 reduce reduce VBP cord-267475-6f4h3cck 853 6 translational translational JJ cord-267475-6f4h3cck 853 7 efficiency efficiency NN cord-267475-6f4h3cck 853 8 and and CC cord-267475-6f4h3cck 853 9 that that DT cord-267475-6f4h3cck 853 10 is be VBZ cord-267475-6f4h3cck 853 11 why why WRB cord-267475-6f4h3cck 853 12 they -PRON- PRP cord-267475-6f4h3cck 853 13 are be VBP cord-267475-6f4h3cck 853 14 there there RB cord-267475-6f4h3cck 853 15 . . . cord-267475-6f4h3cck 854 1 To to TO cord-267475-6f4h3cck 854 2 postulate postulate VB cord-267475-6f4h3cck 854 3 the the DT cord-267475-6f4h3cck 854 4 need need NN cord-267475-6f4h3cck 854 5 for for IN cord-267475-6f4h3cck 854 6 an an DT cord-267475-6f4h3cck 854 7 alternative alternative JJ cord-267475-6f4h3cck 854 8 mechanism mechanism NN cord-267475-6f4h3cck 854 9 is be VBZ cord-267475-6f4h3cck 854 10 to to TO cord-267475-6f4h3cck 854 11 miss miss VB cord-267475-6f4h3cck 854 12 the the DT cord-267475-6f4h3cck 854 13 point point NN cord-267475-6f4h3cck 854 14 that that IN cord-267475-6f4h3cck 854 15 an an DT cord-267475-6f4h3cck 854 16 encumbered encumbered JJ cord-267475-6f4h3cck 854 17 leader leader NN cord-267475-6f4h3cck 854 18 sequence sequence NN cord-267475-6f4h3cck 854 19 ensures ensure VBZ cord-267475-6f4h3cck 854 20 that that DT cord-267475-6f4h3cck 854 21 translation translation NN cord-267475-6f4h3cck 854 22 via via IN cord-267475-6f4h3cck 854 23 scanning scanning NN cord-267475-6f4h3cck 854 24 will will MD cord-267475-6f4h3cck 854 25 be be VB cord-267475-6f4h3cck 854 26 inefficient inefficient JJ cord-267475-6f4h3cck 854 27 , , , cord-267475-6f4h3cck 854 28 and and CC cord-267475-6f4h3cck 854 29 thus thus RB cord-267475-6f4h3cck 854 30 ensures ensure VBZ cord-267475-6f4h3cck 854 31 against against IN cord-267475-6f4h3cck 854 32 harmful harmful JJ cord-267475-6f4h3cck 854 33 overproduction overproduction NN cord-267475-6f4h3cck 854 34 of of IN cord-267475-6f4h3cck 854 35 cytokines cytokine NNS cord-267475-6f4h3cck 854 36 ( ( -LRB- cord-267475-6f4h3cck 854 37 Fig Fig NNP cord-267475-6f4h3cck 854 38 . . NNP cord-267475-6f4h3cck 854 39 4 4 CD cord-267475-6f4h3cck 854 40 ) ) -RRB- cord-267475-6f4h3cck 854 41 and and CC cord-267475-6f4h3cck 854 42 other other JJ cord-267475-6f4h3cck 854 43 potent potent JJ cord-267475-6f4h3cck 854 44 proteins protein NNS cord-267475-6f4h3cck 854 45 . . . cord-267475-6f4h3cck 855 1 The the DT cord-267475-6f4h3cck 855 2 high high JJ cord-267475-6f4h3cck 855 3 frequency frequency NN cord-267475-6f4h3cck 855 4 of of IN cord-267475-6f4h3cck 855 5 intron intron NN cord-267475-6f4h3cck 855 6 - - HYPH cord-267475-6f4h3cck 855 7 containing contain VBG cord-267475-6f4h3cck 855 8 cDNA cdna NN cord-267475-6f4h3cck 855 9 sequences sequence NNS cord-267475-6f4h3cck 855 10 ( ( -LRB- cord-267475-6f4h3cck 855 11 Kozak Kozak NNP cord-267475-6f4h3cck 855 12 , , , cord-267475-6f4h3cck 855 13 1991a 1991a CD cord-267475-6f4h3cck 855 14 ( ( -LRB- cord-267475-6f4h3cck 855 15 Kozak Kozak NNP cord-267475-6f4h3cck 855 16 , , , cord-267475-6f4h3cck 855 17 , , , cord-267475-6f4h3cck 855 18 1996 1996 CD cord-267475-6f4h3cck 855 19 might may MD cord-267475-6f4h3cck 855 20 reflect reflect VB cord-267475-6f4h3cck 855 21 another another DT cord-267475-6f4h3cck 855 22 type type NN cord-267475-6f4h3cck 855 23 of of IN cord-267475-6f4h3cck 855 24 regulation regulation NN cord-267475-6f4h3cck 855 25 . . . cord-267475-6f4h3cck 856 1 Inefficient inefficient JJ cord-267475-6f4h3cck 856 2 or or CC cord-267475-6f4h3cck 856 3 regulated regulated JJ cord-267475-6f4h3cck 856 4 removal removal NN cord-267475-6f4h3cck 856 5 of of IN cord-267475-6f4h3cck 856 6 the the DT cord-267475-6f4h3cck 856 7 first first JJ cord-267475-6f4h3cck 856 8 intron intron NN cord-267475-6f4h3cck 856 9 has have VBZ cord-267475-6f4h3cck 856 10 been be VBN cord-267475-6f4h3cck 856 11 documented document VBN cord-267475-6f4h3cck 856 12 in in IN cord-267475-6f4h3cck 856 13 some some DT cord-267475-6f4h3cck 856 14 cases case NNS cord-267475-6f4h3cck 856 15 ( ( -LRB- cord-267475-6f4h3cck 856 16 Boularand Boularand NNP cord-267475-6f4h3cck 856 17 et et NNP cord-267475-6f4h3cck 856 18 al al NNP cord-267475-6f4h3cck 856 19 . . . cord-267475-6f4h3cck 857 1 , , , cord-267475-6f4h3cck 857 2 1995 1995 CD cord-267475-6f4h3cck 857 3 ; ; : cord-267475-6f4h3cck 857 4 Frost Frost NNP cord-267475-6f4h3cck 857 5 et et FW cord-267475-6f4h3cck 857 6 al al NNP cord-267475-6f4h3cck 857 7 . . NNP cord-267475-6f4h3cck 857 8 , , , cord-267475-6f4h3cck 857 9 2000 2000 CD cord-267475-6f4h3cck 857 10 ; ; : cord-267475-6f4h3cck 857 11 Van Van NNP cord-267475-6f4h3cck 857 12 der der NNP cord-267475-6f4h3cck 857 13 Leij Leij NNP cord-267475-6f4h3cck 857 14 et et NNP cord-267475-6f4h3cck 857 15 al al NNP cord-267475-6f4h3cck 857 16 . . . cord-267475-6f4h3cck 858 1 , , , cord-267475-6f4h3cck 858 2 2002 2002 CD cord-267475-6f4h3cck 858 3 ; ; : cord-267475-6f4h3cck 858 4 Wang Wang NNP cord-267475-6f4h3cck 858 5 and and CC cord-267475-6f4h3cck 858 6 Rothnagel Rothnagel NNP cord-267475-6f4h3cck 858 7 , , , cord-267475-6f4h3cck 858 8 2001 2001 CD cord-267475-6f4h3cck 858 9 ; ; : cord-267475-6f4h3cck 858 10 Xie Xie NNP cord-267475-6f4h3cck 858 11 et et NNP cord-267475-6f4h3cck 858 12 al al NNP cord-267475-6f4h3cck 858 13 . . NNP cord-267475-6f4h3cck 858 14 , , , cord-267475-6f4h3cck 858 15 1991 1991 CD cord-267475-6f4h3cck 858 16 ; ; : cord-267475-6f4h3cck 858 17 Zachar Zachar NNP cord-267475-6f4h3cck 858 18 et et NNP cord-267475-6f4h3cck 858 19 al al NNP cord-267475-6f4h3cck 858 20 . . NNP cord-267475-6f4h3cck 858 21 , , , cord-267475-6f4h3cck 858 22 1987 1987 CD cord-267475-6f4h3cck 858 23 ) ) -RRB- cord-267475-6f4h3cck 858 24 and and CC cord-267475-6f4h3cck 858 25 I -PRON- PRP cord-267475-6f4h3cck 858 26 suspect suspect VBP cord-267475-6f4h3cck 858 27 that that IN cord-267475-6f4h3cck 858 28 additional additional JJ cord-267475-6f4h3cck 858 29 examples example NNS cord-267475-6f4h3cck 858 30 might may MD cord-267475-6f4h3cck 858 31 be be VB cord-267475-6f4h3cck 858 32 found find VBN cord-267475-6f4h3cck 859 1 -miscategorized -miscategorized JJ cord-267475-6f4h3cck 860 1 -among -among . cord-267475-6f4h3cck 861 1 the the DT cord-267475-6f4h3cck 861 2 aforementioned aforementioned JJ cord-267475-6f4h3cck 861 3 cDNAs cDNAs NNPS cord-267475-6f4h3cck 861 4 that that WDT cord-267475-6f4h3cck 861 5 are be VBP cord-267475-6f4h3cck 861 6 postulated postulate VBN cord-267475-6f4h3cck 861 7 to to TO cord-267475-6f4h3cck 861 8 require require VB cord-267475-6f4h3cck 861 9 an an DT cord-267475-6f4h3cck 861 10 alternative alternative JJ cord-267475-6f4h3cck 861 11 mechanism mechanism NN cord-267475-6f4h3cck 861 12 of of IN cord-267475-6f4h3cck 861 13 initiation initiation NN cord-267475-6f4h3cck 861 14 . . . cord-267475-6f4h3cck 862 1 Removal removal NN cord-267475-6f4h3cck 862 2 of of IN cord-267475-6f4h3cck 862 3 the the DT cord-267475-6f4h3cck 862 4 intron intron NN cord-267475-6f4h3cck 862 5 , , , cord-267475-6f4h3cck 862 6 or or CC cord-267475-6f4h3cck 862 7 use use NN cord-267475-6f4h3cck 862 8 of of IN cord-267475-6f4h3cck 862 9 a a DT cord-267475-6f4h3cck 862 10 cryptic cryptic JJ cord-267475-6f4h3cck 862 11 promoter promoter NN cord-267475-6f4h3cck 862 12 therein therein RB cord-267475-6f4h3cck 862 13 , , , cord-267475-6f4h3cck 862 14 would would MD cord-267475-6f4h3cck 862 15 eliminate eliminate VB cord-267475-6f4h3cck 862 16 the the DT cord-267475-6f4h3cck 862 17 upstream upstream JJ cord-267475-6f4h3cck 862 18 AUG AUG NNP cord-267475-6f4h3cck 862 19 codons codon NNS cord-267475-6f4h3cck 862 20 that that WDT cord-267475-6f4h3cck 862 21 are be VBP cord-267475-6f4h3cck 862 22 barriers barrier NNS cord-267475-6f4h3cck 862 23 to to IN cord-267475-6f4h3cck 862 24 scanning scanning NN cord-267475-6f4h3cck 862 25 . . . cord-267475-6f4h3cck 863 1 Examples example NNS cord-267475-6f4h3cck 863 2 in in IN cord-267475-6f4h3cck 863 3 which which WDT cord-267475-6f4h3cck 863 4 translation translation NN cord-267475-6f4h3cck 863 5 is be VBZ cord-267475-6f4h3cck 863 6 prevented prevent VBN cord-267475-6f4h3cck 863 7 deliberately deliberately RB cord-267475-6f4h3cck 863 8 by by IN cord-267475-6f4h3cck 863 9 splicing splicing NN cord-267475-6f4h3cck 863 10 - - HYPH cord-267475-6f4h3cck 863 11 out out RP cord-267475-6f4h3cck 863 12 the the DT cord-267475-6f4h3cck 863 13 exon exon NN cord-267475-6f4h3cck 863 14 that that WDT cord-267475-6f4h3cck 863 15 contains contain VBZ cord-267475-6f4h3cck 863 16 the the DT cord-267475-6f4h3cck 863 17 AUG AUG NNP cord-267475-6f4h3cck 863 18 START START NNP cord-267475-6f4h3cck 863 19 codon codon NN cord-267475-6f4h3cck 863 20 ( ( -LRB- cord-267475-6f4h3cck 863 21 Lin Lin NNP cord-267475-6f4h3cck 863 22 et et NNP cord-267475-6f4h3cck 863 23 al al NNP cord-267475-6f4h3cck 863 24 . . NNP cord-267475-6f4h3cck 863 25 , , , cord-267475-6f4h3cck 863 26 1998 1998 CD cord-267475-6f4h3cck 863 27 ) ) -RRB- cord-267475-6f4h3cck 863 28 or or CC cord-267475-6f4h3cck 863 29 by by IN cord-267475-6f4h3cck 863 30 other other JJ cord-267475-6f4h3cck 863 31 regulated regulate VBN cord-267475-6f4h3cck 863 32 splicing splicing NN cord-267475-6f4h3cck 863 33 events event NNS cord-267475-6f4h3cck 864 1 ( ( -LRB- cord-267475-6f4h3cck 864 2 Rueter Rueter NNP cord-267475-6f4h3cck 864 3 et et NNP cord-267475-6f4h3cck 864 4 al al NNP cord-267475-6f4h3cck 864 5 . . NNP cord-267475-6f4h3cck 864 6 , , , cord-267475-6f4h3cck 864 7 1999 1999 CD cord-267475-6f4h3cck 864 8 ) ) -RRB- cord-267475-6f4h3cck 864 9 underscore underscore VBP cord-267475-6f4h3cck 864 10 the the DT cord-267475-6f4h3cck 864 11 point point NN cord-267475-6f4h3cck 864 12 that that IN cord-267475-6f4h3cck 864 13 not not RB cord-267475-6f4h3cck 864 14 every every DT cord-267475-6f4h3cck 864 15 transcript transcript NN cord-267475-6f4h3cck 864 16 -hence -hence NN cord-267475-6f4h3cck 865 1 not not RB cord-267475-6f4h3cck 865 2 every every DT cord-267475-6f4h3cck 865 3 cDNA cdna NN cord-267475-6f4h3cck 865 4 -corresponds -correspond NNS cord-267475-6f4h3cck 865 5 to to IN cord-267475-6f4h3cck 865 6 a a DT cord-267475-6f4h3cck 865 7 functional functional JJ cord-267475-6f4h3cck 865 8 mRNA mrna NN cord-267475-6f4h3cck 865 9 . . . cord-267475-6f4h3cck 866 1 Before before IN cord-267475-6f4h3cck 866 2 postulating postulate VBG cord-267475-6f4h3cck 866 3 the the DT cord-267475-6f4h3cck 866 4 need need NN cord-267475-6f4h3cck 866 5 for for IN cord-267475-6f4h3cck 866 6 a a DT cord-267475-6f4h3cck 866 7 new new JJ cord-267475-6f4h3cck 866 8 mechanism mechanism NN cord-267475-6f4h3cck 866 9 to to TO cord-267475-6f4h3cck 866 10 explain explain VB cord-267475-6f4h3cck 866 11 how how WRB cord-267475-6f4h3cck 866 12 a a DT cord-267475-6f4h3cck 866 13 funny funny JJ cord-267475-6f4h3cck 866 14 looking look VBG cord-267475-6f4h3cck 866 15 cDNA cdna NN cord-267475-6f4h3cck 866 16 gets get VBZ cord-267475-6f4h3cck 866 17 translated translate VBN cord-267475-6f4h3cck 866 18 , , , cord-267475-6f4h3cck 866 19 one one PRP cord-267475-6f4h3cck 866 20 must must MD cord-267475-6f4h3cck 866 21 be be VB cord-267475-6f4h3cck 866 22 certain certain JJ cord-267475-6f4h3cck 866 23 that that IN cord-267475-6f4h3cck 866 24 it -PRON- PRP cord-267475-6f4h3cck 866 25 is be VBZ cord-267475-6f4h3cck 866 26 translated translate VBN cord-267475-6f4h3cck 866 27 . . . cord-267475-6f4h3cck 867 1 The the DT cord-267475-6f4h3cck 867 2 mechanisms mechanism NNS cord-267475-6f4h3cck 867 3 discussed discuss VBN cord-267475-6f4h3cck 867 4 herein herein RB cord-267475-6f4h3cck 867 5 for for IN cord-267475-6f4h3cck 867 6 escaping escape VBG cord-267475-6f4h3cck 867 7 the the DT cord-267475-6f4h3cck 867 8 first first JJ cord-267475-6f4h3cck 867 9 - - HYPH cord-267475-6f4h3cck 867 10 AUG AUG NNP cord-267475-6f4h3cck 867 11 rule rule NN cord-267475-6f4h3cck 867 12 , , , cord-267475-6f4h3cck 867 13 within within IN cord-267475-6f4h3cck 867 14 the the DT cord-267475-6f4h3cck 867 15 constraints constraint NNS cord-267475-6f4h3cck 867 16 imposed impose VBN cord-267475-6f4h3cck 867 17 by by IN cord-267475-6f4h3cck 867 18 the the DT cord-267475-6f4h3cck 867 19 scanning scanning NN cord-267475-6f4h3cck 867 20 model model NN cord-267475-6f4h3cck 867 21 , , , cord-267475-6f4h3cck 867 22 obviously obviously RB cord-267475-6f4h3cck 867 23 can can MD cord-267475-6f4h3cck 867 24 not not RB cord-267475-6f4h3cck 867 25 explain explain VB cord-267475-6f4h3cck 867 26 every every DT cord-267475-6f4h3cck 867 27 report report NN cord-267475-6f4h3cck 867 28 of of IN cord-267475-6f4h3cck 867 29 initiation initiation NN cord-267475-6f4h3cck 867 30 from from IN cord-267475-6f4h3cck 867 31 an an DT cord-267475-6f4h3cck 867 32 internal internal JJ cord-267475-6f4h3cck 867 33 position position NN cord-267475-6f4h3cck 867 34 . . . cord-267475-6f4h3cck 868 1 More More JJR cord-267475-6f4h3cck 868 2 information information NN cord-267475-6f4h3cck 868 3 is be VBZ cord-267475-6f4h3cck 868 4 needed need VBN cord-267475-6f4h3cck 868 5 to to TO cord-267475-6f4h3cck 868 6 understand understand VB cord-267475-6f4h3cck 868 7 how how WRB cord-267475-6f4h3cck 868 8 N n NN cord-267475-6f4h3cck 868 9 - - HYPH cord-267475-6f4h3cck 868 10 terminally terminally RB cord-267475-6f4h3cck 868 11 truncated truncate VBN cord-267475-6f4h3cck 868 12 versions version NNS cord-267475-6f4h3cck 868 13 of of IN cord-267475-6f4h3cck 868 14 some some DT cord-267475-6f4h3cck 868 15 proteins protein NNS cord-267475-6f4h3cck 868 16 are be VBP cord-267475-6f4h3cck 868 17 produced produce VBN cord-267475-6f4h3cck 868 18 apparently apparently RB cord-267475-6f4h3cck 868 19 without without IN cord-267475-6f4h3cck 868 20 truncation truncation NN cord-267475-6f4h3cck 868 21 of of IN cord-267475-6f4h3cck 868 22 the the DT cord-267475-6f4h3cck 868 23 mRNA mrna NN cord-267475-6f4h3cck 869 1 ( ( -LRB- cord-267475-6f4h3cck 869 2 Goss Goss NNP cord-267475-6f4h3cck 869 3 et et FW cord-267475-6f4h3cck 869 4 al al NNP cord-267475-6f4h3cck 869 5 . . NNP cord-267475-6f4h3cck 869 6 , , , cord-267475-6f4h3cck 869 7 2002 2002 CD cord-267475-6f4h3cck 870 1 ; ; : cord-267475-6f4h3cck 870 2 Maser Maser NNP cord-267475-6f4h3cck 870 3 et et NNP cord-267475-6f4h3cck 870 4 al al NNP cord-267475-6f4h3cck 870 5 . . NNP cord-267475-6f4h3cck 870 6 , , , cord-267475-6f4h3cck 870 7 2001 2001 CD cord-267475-6f4h3cck 870 8 ; ; : cord-267475-6f4h3cck 870 9 Santagata Santagata NNP cord-267475-6f4h3cck 870 10 et et NNP cord-267475-6f4h3cck 870 11 al al NNP cord-267475-6f4h3cck 870 12 . . NNP cord-267475-6f4h3cck 870 13 , , , cord-267475-6f4h3cck 870 14 2000 2000 CD cord-267475-6f4h3cck 870 15 ; ; : cord-267475-6f4h3cck 870 16 Scharnhorst Scharnhorst NNP cord-267475-6f4h3cck 870 17 et et NNP cord-267475-6f4h3cck 870 18 al al NNP cord-267475-6f4h3cck 870 19 . . NNP cord-267475-6f4h3cck 870 20 , , , cord-267475-6f4h3cck 870 21 1999 1999 CD cord-267475-6f4h3cck 870 22 ; ; : cord-267475-6f4h3cck 871 1 Vanhoutte Vanhoutte NNP cord-267475-6f4h3cck 871 2 et et NNP cord-267475-6f4h3cck 871 3 al al NNP cord-267475-6f4h3cck 871 4 . . NNP cord-267475-6f4h3cck 871 5 , , , cord-267475-6f4h3cck 871 6 2001 2001 CD cord-267475-6f4h3cck 871 7 ) ) -RRB- cord-267475-6f4h3cck 871 8 . . . cord-267475-6f4h3cck 872 1 An an DT cord-267475-6f4h3cck 872 2 IRES ires JJ cord-267475-6f4h3cck 872 3 element element NN cord-267475-6f4h3cck 872 4 was be VBD cord-267475-6f4h3cck 872 5 postulated postulate VBN cord-267475-6f4h3cck 872 6 in in IN cord-267475-6f4h3cck 872 7 some some DT cord-267475-6f4h3cck 872 8 of of IN cord-267475-6f4h3cck 872 9 those those DT cord-267475-6f4h3cck 872 10 cases case NNS cord-267475-6f4h3cck 872 11 , , , cord-267475-6f4h3cck 872 12 based base VBN cord-267475-6f4h3cck 872 13 on on IN cord-267475-6f4h3cck 872 14 the the DT cord-267475-6f4h3cck 872 15 dicistronic dicistronic JJ cord-267475-6f4h3cck 872 16 test test NN cord-267475-6f4h3cck 872 17 , , , cord-267475-6f4h3cck 872 18 but but CC cord-267475-6f4h3cck 872 19 in in IN cord-267475-6f4h3cck 872 20 one one CD cord-267475-6f4h3cck 872 21 study study NN cord-267475-6f4h3cck 872 22 there there EX cord-267475-6f4h3cck 872 23 were be VBD cord-267475-6f4h3cck 872 24 no no DT cord-267475-6f4h3cck 872 25 accompanying accompany VBG cord-267475-6f4h3cck 872 26 analyses analysis NNS cord-267475-6f4h3cck 872 27 of of IN cord-267475-6f4h3cck 872 28 RNA RNA NNP cord-267475-6f4h3cck 872 29 structure structure NN cord-267475-6f4h3cck 872 30 in in IN cord-267475-6f4h3cck 872 31 vivo vivo NN cord-267475-6f4h3cck 873 1 ( ( -LRB- cord-267475-6f4h3cck 873 2 Goss Goss NNP cord-267475-6f4h3cck 873 3 et et FW cord-267475-6f4h3cck 873 4 al al NNP cord-267475-6f4h3cck 873 5 . . NNP cord-267475-6f4h3cck 873 6 , , , cord-267475-6f4h3cck 873 7 2002 2002 CD cord-267475-6f4h3cck 873 8 ) ) -RRB- cord-267475-6f4h3cck 873 9 , , , cord-267475-6f4h3cck 873 10 and and CC cord-267475-6f4h3cck 873 11 in in IN cord-267475-6f4h3cck 873 12 another another DT cord-267475-6f4h3cck 873 13 study study NN cord-267475-6f4h3cck 873 14 the the DT cord-267475-6f4h3cck 873 15 use use NN cord-267475-6f4h3cck 873 16 of of IN cord-267475-6f4h3cck 873 17 an an DT cord-267475-6f4h3cck 873 18 in in FW cord-267475-6f4h3cck 873 19 vitro vitro FW cord-267475-6f4h3cck 873 20 translation translation NN cord-267475-6f4h3cck 873 21 system system NN cord-267475-6f4h3cck 873 22 produced produce VBD cord-267475-6f4h3cck 873 23 too too RB cord-267475-6f4h3cck 873 24 little little JJ cord-267475-6f4h3cck 873 25 of of IN cord-267475-6f4h3cck 873 26 the the DT cord-267475-6f4h3cck 873 27 truncated truncated JJ cord-267475-6f4h3cck 873 28 protein protein NN cord-267475-6f4h3cck 873 29 to to TO cord-267475-6f4h3cck 873 30 be be VB cord-267475-6f4h3cck 873 31 convincing convincing JJ cord-267475-6f4h3cck 873 32 ( ( -LRB- cord-267475-6f4h3cck 873 33 Maser Maser NNP cord-267475-6f4h3cck 873 34 et et NNP cord-267475-6f4h3cck 873 35 al al NNP cord-267475-6f4h3cck 873 36 . . NNP cord-267475-6f4h3cck 873 37 , , , cord-267475-6f4h3cck 873 38 2001 2001 CD cord-267475-6f4h3cck 873 39 ) ) -RRB- cord-267475-6f4h3cck 873 40 . . . cord-267475-6f4h3cck 874 1 Speculation speculation NN cord-267475-6f4h3cck 874 2 about about IN cord-267475-6f4h3cck 874 3 how how WRB cord-267475-6f4h3cck 874 4 some some DT cord-267475-6f4h3cck 874 5 other other JJ cord-267475-6f4h3cck 874 6 interesting interesting JJ cord-267475-6f4h3cck 874 7 genes gene NNS cord-267475-6f4h3cck 874 8 are be VBP cord-267475-6f4h3cck 874 9 translated translate VBN cord-267475-6f4h3cck 874 10 ( ( -LRB- cord-267475-6f4h3cck 874 11 Klemke Klemke NNP cord-267475-6f4h3cck 874 12 et et NNP cord-267475-6f4h3cck 874 13 al al NNP cord-267475-6f4h3cck 874 14 . . NNP cord-267475-6f4h3cck 874 15 , , , cord-267475-6f4h3cck 874 16 2001 2001 CD cord-267475-6f4h3cck 874 17 ) ) -RRB- cord-267475-6f4h3cck 874 18 also also RB cord-267475-6f4h3cck 874 19 must must MD cord-267475-6f4h3cck 874 20 be be VB cord-267475-6f4h3cck 874 21 postponed postpone VBN cord-267475-6f4h3cck 874 22 pending pende VBG cord-267475-6f4h3cck 874 23 a a DT cord-267475-6f4h3cck 874 24 search search NN cord-267475-6f4h3cck 874 25 for for IN cord-267475-6f4h3cck 874 26 possible possible JJ cord-267475-6f4h3cck 874 27 additional additional JJ cord-267475-6f4h3cck 874 28 forms form NNS cord-267475-6f4h3cck 874 29 of of IN cord-267475-6f4h3cck 874 30 mRNA mrna NN cord-267475-6f4h3cck 874 31 . . . cord-267475-6f4h3cck 875 1 Although although IN cord-267475-6f4h3cck 875 2 I -PRON- PRP cord-267475-6f4h3cck 875 3 listed list VBD cord-267475-6f4h3cck 875 4 the the DT cord-267475-6f4h3cck 875 5 von von NNP cord-267475-6f4h3cck 875 6 Hippel Hippel NNP cord-267475-6f4h3cck 875 7 - - HYPH cord-267475-6f4h3cck 875 8 Lindau Lindau NNP cord-267475-6f4h3cck 875 9 tumor tumor NN cord-267475-6f4h3cck 875 10 suppressor suppressor NN cord-267475-6f4h3cck 875 11 gene gene NN cord-267475-6f4h3cck 875 12 as as IN cord-267475-6f4h3cck 875 13 a a DT cord-267475-6f4h3cck 875 14 possible possible JJ cord-267475-6f4h3cck 875 15 example example NN cord-267475-6f4h3cck 875 16 of of IN cord-267475-6f4h3cck 875 17 leaky leaky JJ cord-267475-6f4h3cck 875 18 scanning scanning NN cord-267475-6f4h3cck 875 19 ( ( -LRB- cord-267475-6f4h3cck 875 20 Table Table NNP cord-267475-6f4h3cck 875 21 3 3 CD cord-267475-6f4h3cck 875 22 ) ) -RRB- cord-267475-6f4h3cck 875 23 , , , cord-267475-6f4h3cck 875 24 definitive definitive JJ cord-267475-6f4h3cck 875 25 tests test NNS cord-267475-6f4h3cck 875 26 are be VBP cord-267475-6f4h3cck 875 27 needed need VBN cord-267475-6f4h3cck 875 28 to to TO cord-267475-6f4h3cck 875 29 distinguish distinguish VB cord-267475-6f4h3cck 875 30 between between IN cord-267475-6f4h3cck 875 31 that that DT cord-267475-6f4h3cck 875 32 and and CC cord-267475-6f4h3cck 875 33 other other JJ cord-267475-6f4h3cck 875 34 mechanisms mechanism NNS cord-267475-6f4h3cck 875 35 for for IN cord-267475-6f4h3cck 875 36 producing produce VBG cord-267475-6f4h3cck 875 37 the the DT cord-267475-6f4h3cck 875 38 short short JJ cord-267475-6f4h3cck 875 39 isoform isoform NN cord-267475-6f4h3cck 875 40 ( ( -LRB- cord-267475-6f4h3cck 875 41 Iliopoulos Iliopoulos NNP cord-267475-6f4h3cck 875 42 et et NNP cord-267475-6f4h3cck 875 43 al al NNP cord-267475-6f4h3cck 875 44 . . NNP cord-267475-6f4h3cck 875 45 , , , cord-267475-6f4h3cck 875 46 1998 1998 CD cord-267475-6f4h3cck 875 47 ) ) -RRB- cord-267475-6f4h3cck 875 48 . . . cord-267475-6f4h3cck 876 1 Those those DT cord-267475-6f4h3cck 876 2 of of IN cord-267475-6f4h3cck 876 3 us -PRON- PRP cord-267475-6f4h3cck 876 4 with with IN cord-267475-6f4h3cck 876 5 an an DT cord-267475-6f4h3cck 876 6 interest interest NN cord-267475-6f4h3cck 876 7 in in IN cord-267475-6f4h3cck 876 8 translation translation NN cord-267475-6f4h3cck 876 9 have have VBP cord-267475-6f4h3cck 876 10 a a DT cord-267475-6f4h3cck 876 11 tendency tendency NN cord-267475-6f4h3cck 876 12 to to TO cord-267475-6f4h3cck 876 13 interpret interpret VB cord-267475-6f4h3cck 876 14 every every DT cord-267475-6f4h3cck 876 15 change change NN cord-267475-6f4h3cck 876 16 in in IN cord-267475-6f4h3cck 876 17 mRNA mRNA NNP cord-267475-6f4h3cck 876 18 structure structure NN cord-267475-6f4h3cck 876 19 as as IN cord-267475-6f4h3cck 876 20 a a DT cord-267475-6f4h3cck 876 21 means means NN cord-267475-6f4h3cck 876 22 to to TO cord-267475-6f4h3cck 876 23 control control VB cord-267475-6f4h3cck 876 24 translation translation NN cord-267475-6f4h3cck 876 25 , , , cord-267475-6f4h3cck 876 26 but but CC cord-267475-6f4h3cck 876 27 transcriptional transcriptional JJ cord-267475-6f4h3cck 876 28 requirements requirement NNS cord-267475-6f4h3cck 876 29 -the -the WDT cord-267475-6f4h3cck 876 30 need need VBP cord-267475-6f4h3cck 876 31 to to TO cord-267475-6f4h3cck 876 32 turn turn VB cord-267475-6f4h3cck 876 33 on on RP cord-267475-6f4h3cck 876 34 a a DT cord-267475-6f4h3cck 876 35 gene gene NN cord-267475-6f4h3cck 876 36 in in IN cord-267475-6f4h3cck 876 37 various various JJ cord-267475-6f4h3cck 876 38 tissues tissue NNS cord-267475-6f4h3cck 876 39 via via IN cord-267475-6f4h3cck 876 40 whatever whatever WDT cord-267475-6f4h3cck 876 41 promoter promoter NN cord-267475-6f4h3cck 876 42 works work VBZ cord-267475-6f4h3cck 876 43 in in IN cord-267475-6f4h3cck 876 44 each each DT cord-267475-6f4h3cck 876 45 tissue tissue NN cord-267475-6f4h3cck 877 1 -underlie -underlie NFP cord-267475-6f4h3cck 877 2 most most JJS cord-267475-6f4h3cck 877 3 switches switch NNS cord-267475-6f4h3cck 877 4 in in IN cord-267475-6f4h3cck 877 5 5 5 CD cord-267475-6f4h3cck 877 6 0 0 CD cord-267475-6f4h3cck 877 7 leader leader NN cord-267475-6f4h3cck 877 8 sequences sequence NNS cord-267475-6f4h3cck 877 9 . . . cord-267475-6f4h3cck 878 1 In in IN cord-267475-6f4h3cck 878 2 some some DT cord-267475-6f4h3cck 878 3 cases case NNS cord-267475-6f4h3cck 878 4 the the DT cord-267475-6f4h3cck 878 5 actual actual JJ cord-267475-6f4h3cck 878 6 sequence sequence NN cord-267475-6f4h3cck 878 7 of of IN cord-267475-6f4h3cck 878 8 the the DT cord-267475-6f4h3cck 878 9 5 5 CD cord-267475-6f4h3cck 878 10 0 0 CD cord-267475-6f4h3cck 878 11 UTR UTR NNP cord-267475-6f4h3cck 878 12 is be VBZ cord-267475-6f4h3cck 878 13 dictated dictate VBN cord-267475-6f4h3cck 878 14 by by IN cord-267475-6f4h3cck 878 15 the the DT cord-267475-6f4h3cck 878 16 presence presence NN cord-267475-6f4h3cck 878 17 therein therein RB cord-267475-6f4h3cck 878 18 of of IN cord-267475-6f4h3cck 878 19 transcriptional transcriptional JJ cord-267475-6f4h3cck 878 20 control control NN cord-267475-6f4h3cck 878 21 elements element NNS cord-267475-6f4h3cck 878 22 ( ( -LRB- cord-267475-6f4h3cck 878 23 Akiri Akiri NNP cord-267475-6f4h3cck 878 24 et et NNP cord-267475-6f4h3cck 878 25 al al NNP cord-267475-6f4h3cck 878 26 . . NNP cord-267475-6f4h3cck 878 27 , , , cord-267475-6f4h3cck 878 28 1998 1998 CD cord-267475-6f4h3cck 878 29 ; ; : cord-267475-6f4h3cck 878 30 Minami Minami NNP cord-267475-6f4h3cck 878 31 et et NNP cord-267475-6f4h3cck 878 32 al al NNP cord-267475-6f4h3cck 878 33 . . . cord-267475-6f4h3cck 879 1 , , , cord-267475-6f4h3cck 879 2 2001 2001 CD cord-267475-6f4h3cck 879 3 ; ; : cord-267475-6f4h3cck 879 4 Solecki Solecki NNP cord-267475-6f4h3cck 879 5 et et NNP cord-267475-6f4h3cck 879 6 al al NNP cord-267475-6f4h3cck 879 7 . . NNP cord-267475-6f4h3cck 879 8 , , , cord-267475-6f4h3cck 879 9 1997 1997 CD cord-267475-6f4h3cck 879 10 ; ; : cord-267475-6f4h3cck 879 11 Yin Yin NNP cord-267475-6f4h3cck 879 12 and and CC cord-267475-6f4h3cck 879 13 Blanchard Blanchard NNP cord-267475-6f4h3cck 879 14 , , , cord-267475-6f4h3cck 879 15 2000 2000 CD cord-267475-6f4h3cck 879 16 ; ; : cord-267475-6f4h3cck 879 17 Yu Yu NNP cord-267475-6f4h3cck 879 18 et et NNP cord-267475-6f4h3cck 879 19 al al NNP cord-267475-6f4h3cck 879 20 . . NNP cord-267475-6f4h3cck 879 21 , , , cord-267475-6f4h3cck 879 22 2001 2001 CD cord-267475-6f4h3cck 879 23 ; ; : cord-267475-6f4h3cck 879 24 Zimmermann Zimmermann NNP cord-267475-6f4h3cck 879 25 et et NNP cord-267475-6f4h3cck 879 26 al al NNP cord-267475-6f4h3cck 879 27 . . NNP cord-267475-6f4h3cck 879 28 , , , cord-267475-6f4h3cck 879 29 2000 2000 CD cord-267475-6f4h3cck 879 30 ) ) -RRB- cord-267475-6f4h3cck 879 31 . . . cord-267475-6f4h3cck 880 1 Regulation regulation NN cord-267475-6f4h3cck 880 2 of of IN cord-267475-6f4h3cck 880 3 transcription transcription NN cord-267475-6f4h3cck 880 4 is be VBZ cord-267475-6f4h3cck 880 5 the the DT cord-267475-6f4h3cck 880 6 major major JJ cord-267475-6f4h3cck 880 7 reason reason NN cord-267475-6f4h3cck 880 8 for for IN cord-267475-6f4h3cck 880 9 the the DT cord-267475-6f4h3cck 880 10 GC GC NNP cord-267475-6f4h3cck 880 11 - - HYPH cord-267475-6f4h3cck 880 12 rich rich JJ cord-267475-6f4h3cck 880 13 domains domain NNS cord-267475-6f4h3cck 880 14 near near IN cord-267475-6f4h3cck 880 15 the the DT cord-267475-6f4h3cck 880 16 5 5 CD cord-267475-6f4h3cck 880 17 0 0 CD cord-267475-6f4h3cck 880 18 end end NN cord-267475-6f4h3cck 880 19 of of IN cord-267475-6f4h3cck 880 20 many many JJ cord-267475-6f4h3cck 880 21 mammalian mammalian JJ cord-267475-6f4h3cck 880 22 genes gene NNS cord-267475-6f4h3cck 880 23 ; ; : cord-267475-6f4h3cck 880 24 the the DT cord-267475-6f4h3cck 880 25 accompanying accompany VBG cord-267475-6f4h3cck 880 26 down down JJ cord-267475-6f4h3cck 880 27 - - HYPH cord-267475-6f4h3cck 880 28 modulation modulation NN cord-267475-6f4h3cck 880 29 of of IN cord-267475-6f4h3cck 880 30 translation translation NN cord-267475-6f4h3cck 880 31 is be VBZ cord-267475-6f4h3cck 880 32 an an DT cord-267475-6f4h3cck 880 33 inevitable inevitable JJ cord-267475-6f4h3cck 880 34 consequence consequence NN cord-267475-6f4h3cck 880 35 -arguably -arguably IN cord-267475-6f4h3cck 880 36 a a DT cord-267475-6f4h3cck 880 37 useful useful JJ cord-267475-6f4h3cck 880 38 consequence consequence NN cord-267475-6f4h3cck 880 39 because because IN cord-267475-6f4h3cck 880 40 , , , cord-267475-6f4h3cck 880 41 given give VBN cord-267475-6f4h3cck 880 42 the the DT cord-267475-6f4h3cck 880 43 long long JJ cord-267475-6f4h3cck 880 44 half half JJ cord-267475-6f4h3cck 880 45 - - HYPH cord-267475-6f4h3cck 880 46 life life NN cord-267475-6f4h3cck 880 47 of of IN cord-267475-6f4h3cck 880 48 most most JJS cord-267475-6f4h3cck 880 49 mammalian mammalian JJ cord-267475-6f4h3cck 880 50 mRNAs mRNAs NNPS cord-267475-6f4h3cck 880 51 , , , cord-267475-6f4h3cck 880 52 inefficient inefficient JJ cord-267475-6f4h3cck 880 53 translation translation NN cord-267475-6f4h3cck 880 54 might may MD cord-267475-6f4h3cck 880 55 be be VB cord-267475-6f4h3cck 880 56 a a DT cord-267475-6f4h3cck 880 57 necessity necessity NN cord-267475-6f4h3cck 880 58 . . . cord-267475-6f4h3cck 881 1 It -PRON- PRP cord-267475-6f4h3cck 881 2 merits merit VBZ cord-267475-6f4h3cck 881 3 repeating repeat VBG cord-267475-6f4h3cck 881 4 that that IN cord-267475-6f4h3cck 881 5 , , , cord-267475-6f4h3cck 881 6 although although IN cord-267475-6f4h3cck 881 7 the the DT cord-267475-6f4h3cck 881 8 m7 m7 NN cord-267475-6f4h3cck 881 9 G g NN cord-267475-6f4h3cck 881 10 cap cap NN cord-267475-6f4h3cck 881 11 strongly strongly RB cord-267475-6f4h3cck 881 12 promotes promote VBZ cord-267475-6f4h3cck 881 13 ribosome ribosome NN cord-267475-6f4h3cck 881 14 binding binding NN cord-267475-6f4h3cck 881 15 , , , cord-267475-6f4h3cck 881 16 the the DT cord-267475-6f4h3cck 881 17 scanning scanning NN cord-267475-6f4h3cck 881 18 mechanism mechanism NN cord-267475-6f4h3cck 881 19 is be VBZ cord-267475-6f4h3cck 881 20 not not RB cord-267475-6f4h3cck 881 21 dependent dependent JJ cord-267475-6f4h3cck 881 22 on on IN cord-267475-6f4h3cck 881 23 the the DT cord-267475-6f4h3cck 881 24 presence presence NN cord-267475-6f4h3cck 881 25 of of IN cord-267475-6f4h3cck 881 26 the the DT cord-267475-6f4h3cck 881 27 cap cap NN cord-267475-6f4h3cck 881 28 . . . cord-267475-6f4h3cck 882 1 The the DT cord-267475-6f4h3cck 882 2 essence essence NN cord-267475-6f4h3cck 882 3 of of IN cord-267475-6f4h3cck 882 4 the the DT cord-267475-6f4h3cck 882 5 scanning scanning NN cord-267475-6f4h3cck 882 6 model model NN cord-267475-6f4h3cck 882 7 is be VBZ cord-267475-6f4h3cck 882 8 5 5 CD cord-267475-6f4h3cck 882 9 0 0 CD cord-267475-6f4h3cck 882 10 entry entry NN cord-267475-6f4h3cck 882 11 of of IN cord-267475-6f4h3cck 882 12 ribosomes ribosome NNS cord-267475-6f4h3cck 882 13 and and CC cord-267475-6f4h3cck 882 14 positiondependent positiondependent NN cord-267475-6f4h3cck 882 15 selection selection NN cord-267475-6f4h3cck 882 16 of of IN cord-267475-6f4h3cck 882 17 the the DT cord-267475-6f4h3cck 882 18 AUG AUG NNP cord-267475-6f4h3cck 882 19 START START NNP cord-267475-6f4h3cck 882 20 codon codon NN cord-267475-6f4h3cck 882 21 . . . cord-267475-6f4h3cck 883 1 Those those DT cord-267475-6f4h3cck 883 2 key key JJ cord-267475-6f4h3cck 883 3 points point NNS cord-267475-6f4h3cck 883 4 hold hold VBP cord-267475-6f4h3cck 883 5 with with IN cord-267475-6f4h3cck 883 6 naturally naturally RB cord-267475-6f4h3cck 883 7 uncapped uncapped JJ cord-267475-6f4h3cck 883 8 mRNAs mRNAs NNPS cord-267475-6f4h3cck 883 9 produced produce VBN cord-267475-6f4h3cck 883 10 by by IN cord-267475-6f4h3cck 883 11 some some DT cord-267475-6f4h3cck 883 12 viruses virus NNS cord-267475-6f4h3cck 883 13 ( ( -LRB- cord-267475-6f4h3cck 883 14 footnote footnote NN cord-267475-6f4h3cck 883 15 g g NN cord-267475-6f4h3cck 883 16 in in IN cord-267475-6f4h3cck 883 17 Table Table NNP cord-267475-6f4h3cck 883 18 1 1 CD cord-267475-6f4h3cck 883 19 ) ) -RRB- cord-267475-6f4h3cck 883 20 and and CC cord-267475-6f4h3cck 883 21 with with IN cord-267475-6f4h3cck 883 22 synthetic synthetic JJ cord-267475-6f4h3cck 883 23 uncapped uncapped JJ cord-267475-6f4h3cck 883 24 mRNAs mRNAs NNPS cord-267475-6f4h3cck 883 25 used use VBN cord-267475-6f4h3cck 883 26 to to TO cord-267475-6f4h3cck 883 27 study study VB cord-267475-6f4h3cck 883 28 translation translation NN cord-267475-6f4h3cck 883 29 in in IN cord-267475-6f4h3cck 883 30 vitro vitro FW cord-267475-6f4h3cck 883 31 ( ( -LRB- cord-267475-6f4h3cck 883 32 Kozak Kozak NNP cord-267475-6f4h3cck 883 33 , , , cord-267475-6f4h3cck 883 34 1979a 1979a CD cord-267475-6f4h3cck 883 35 . . . cord-267475-6f4h3cck 884 1 The the DT cord-267475-6f4h3cck 884 2 inclination inclination NN cord-267475-6f4h3cck 884 3 to to TO cord-267475-6f4h3cck 884 4 invoke invoke VB cord-267475-6f4h3cck 884 5 internal internal JJ cord-267475-6f4h3cck 884 6 initiation initiation NN cord-267475-6f4h3cck 884 7 based base VBN cord-267475-6f4h3cck 884 8 on on IN cord-267475-6f4h3cck 884 9 indirect indirect JJ cord-267475-6f4h3cck 884 10 criteria criterion NNS cord-267475-6f4h3cck 884 11 -absence -absence NN cord-267475-6f4h3cck 884 12 of of IN cord-267475-6f4h3cck 884 13 a a DT cord-267475-6f4h3cck 884 14 cap cap NN cord-267475-6f4h3cck 884 15 , , , cord-267475-6f4h3cck 884 16 or or CC cord-267475-6f4h3cck 884 17 the the DT cord-267475-6f4h3cck 884 18 ability ability NN cord-267475-6f4h3cck 884 19 to to TO cord-267475-6f4h3cck 884 20 be be VB cord-267475-6f4h3cck 884 21 translated translate VBN cord-267475-6f4h3cck 884 22 in in IN cord-267475-6f4h3cck 884 23 extracts extract NNS cord-267475-6f4h3cck 884 24 from from IN cord-267475-6f4h3cck 884 25 poliovirus poliovirus NN cord-267475-6f4h3cck 884 26 - - HYPH cord-267475-6f4h3cck 884 27 infected infect VBN cord-267475-6f4h3cck 884 28 cells cell NNS cord-267475-6f4h3cck 885 1 -should -should MD cord-267475-6f4h3cck 885 2 be be VB cord-267475-6f4h3cck 885 3 resisted resist VBN cord-267475-6f4h3cck 885 4 . . . cord-267475-6f4h3cck 886 1 It -PRON- PRP cord-267475-6f4h3cck 886 2 is be VBZ cord-267475-6f4h3cck 886 3 a a DT cord-267475-6f4h3cck 886 4 mistake mistake NN cord-267475-6f4h3cck 886 5 to to TO cord-267475-6f4h3cck 886 6 think think VB cord-267475-6f4h3cck 886 7 that that IN cord-267475-6f4h3cck 886 8 , , , cord-267475-6f4h3cck 886 9 because because IN cord-267475-6f4h3cck 886 10 archaeal archaeal JJ cord-267475-6f4h3cck 886 11 mRNAs mrnas CD cord-267475-6f4h3cck 886 12 lack lack VBP cord-267475-6f4h3cck 886 13 a a DT cord-267475-6f4h3cck 886 14 5 5 CD cord-267475-6f4h3cck 886 15 0 0 CD cord-267475-6f4h3cck 886 16 cap cap NN cord-267475-6f4h3cck 886 17 , , , cord-267475-6f4h3cck 886 18 translation translation NN cord-267475-6f4h3cck 886 19 in in IN cord-267475-6f4h3cck 886 20 that that DT cord-267475-6f4h3cck 886 21 system system NN cord-267475-6f4h3cck 886 22 can can MD cord-267475-6f4h3cck 886 23 not not RB cord-267475-6f4h3cck 886 24 occur occur VB cord-267475-6f4h3cck 886 25 via via IN cord-267475-6f4h3cck 886 26 scanning scanning NN cord-267475-6f4h3cck 886 27 . . . cord-267475-6f4h3cck 887 1 The the DT cord-267475-6f4h3cck 887 2 discovery discovery NN cord-267475-6f4h3cck 887 3 in in IN cord-267475-6f4h3cck 887 4 archaea archaea NNS cord-267475-6f4h3cck 887 5 of of IN cord-267475-6f4h3cck 887 6 proteins protein NNS cord-267475-6f4h3cck 887 7 similar similar JJ cord-267475-6f4h3cck 887 8 to to IN cord-267475-6f4h3cck 887 9 certain certain JJ cord-267475-6f4h3cck 887 10 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 887 11 initiation initiation NN cord-267475-6f4h3cck 887 12 factors factor NNS cord-267475-6f4h3cck 887 13 ( ( -LRB- cord-267475-6f4h3cck 887 14 Kyrpides Kyrpides NNP cord-267475-6f4h3cck 887 15 and and CC cord-267475-6f4h3cck 887 16 Woese Woese NNP cord-267475-6f4h3cck 887 17 , , , cord-267475-6f4h3cck 887 18 1998 1998 CD cord-267475-6f4h3cck 887 19 ) ) -RRB- cord-267475-6f4h3cck 887 20 is be VBZ cord-267475-6f4h3cck 887 21 intriguing intriguing JJ cord-267475-6f4h3cck 887 22 for for IN cord-267475-6f4h3cck 887 23 other other JJ cord-267475-6f4h3cck 887 24 reasons reason NNS cord-267475-6f4h3cck 887 25 but but CC cord-267475-6f4h3cck 887 26 has have VBZ cord-267475-6f4h3cck 887 27 no no DT cord-267475-6f4h3cck 887 28 direct direct JJ cord-267475-6f4h3cck 887 29 bearing bearing NN cord-267475-6f4h3cck 887 30 on on IN cord-267475-6f4h3cck 887 31 whether whether IN cord-267475-6f4h3cck 887 32 the the DT cord-267475-6f4h3cck 887 33 start start NN cord-267475-6f4h3cck 887 34 codon codon NN cord-267475-6f4h3cck 887 35 in in IN cord-267475-6f4h3cck 887 36 archaeal archaeal JJ cord-267475-6f4h3cck 887 37 mRNAs mRNAs NNPS cord-267475-6f4h3cck 887 38 might may MD cord-267475-6f4h3cck 887 39 be be VB cord-267475-6f4h3cck 887 40 recognized recognize VBN cord-267475-6f4h3cck 887 41 via via IN cord-267475-6f4h3cck 887 42 a a DT cord-267475-6f4h3cck 887 43 prokaryotic prokaryotic JJ cord-267475-6f4h3cck 887 44 - - HYPH cord-267475-6f4h3cck 887 45 or or CC cord-267475-6f4h3cck 887 46 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 887 47 - - HYPH cord-267475-6f4h3cck 887 48 type type NN cord-267475-6f4h3cck 887 49 mechanism mechanism NN cord-267475-6f4h3cck 887 50 . . . cord-267475-6f4h3cck 888 1 That that DT cord-267475-6f4h3cck 888 2 interesting interesting JJ cord-267475-6f4h3cck 888 3 question question NN cord-267475-6f4h3cck 888 4 , , , cord-267475-6f4h3cck 888 5 which which WDT cord-267475-6f4h3cck 888 6 bears bear VBZ cord-267475-6f4h3cck 888 7 on on IN cord-267475-6f4h3cck 888 8 the the DT cord-267475-6f4h3cck 888 9 evolutionary evolutionary JJ cord-267475-6f4h3cck 888 10 origin origin NN cord-267475-6f4h3cck 888 11 of of IN cord-267475-6f4h3cck 888 12 scanning scanning NN cord-267475-6f4h3cck 888 13 , , , cord-267475-6f4h3cck 888 14 awaits await VBZ cord-267475-6f4h3cck 888 15 answering answer VBG cord-267475-6f4h3cck 888 16 . . . cord-267475-6f4h3cck 889 1 Fundamental fundamental JJ cord-267475-6f4h3cck 889 2 questions question NNS cord-267475-6f4h3cck 889 3 about about IN cord-267475-6f4h3cck 889 4 the the DT cord-267475-6f4h3cck 889 5 molecular molecular JJ cord-267475-6f4h3cck 889 6 workings working NNS cord-267475-6f4h3cck 889 7 of of IN cord-267475-6f4h3cck 889 8 the the DT cord-267475-6f4h3cck 889 9 scanning scanning NN cord-267475-6f4h3cck 889 10 mechanism mechanism NN cord-267475-6f4h3cck 889 11 also also RB cord-267475-6f4h3cck 889 12 await await VBP cord-267475-6f4h3cck 889 13 answering answer VBG cord-267475-6f4h3cck 889 14 . . . cord-267475-6f4h3cck 890 1 What what WP cord-267475-6f4h3cck 890 2 drives drive VBZ cord-267475-6f4h3cck 890 3 migration migration NN cord-267475-6f4h3cck 890 4 of of IN cord-267475-6f4h3cck 890 5 the the DT cord-267475-6f4h3cck 890 6 40S 40s CD cord-267475-6f4h3cck 890 7 subunit subunit NN cord-267475-6f4h3cck 890 8 during during IN cord-267475-6f4h3cck 890 9 the the DT cord-267475-6f4h3cck 890 10 scanning scanning NN cord-267475-6f4h3cck 890 11 phase phase NN cord-267475-6f4h3cck 890 12 ? ? . cord-267475-6f4h3cck 891 1 How how WRB cord-267475-6f4h3cck 891 2 does do VBZ cord-267475-6f4h3cck 891 3 the the DT cord-267475-6f4h3cck 891 4 40S 40s CD cord-267475-6f4h3cck 891 5 subunit subunit NN cord-267475-6f4h3cck 891 6 hold hold NN cord-267475-6f4h3cck 891 7 on on RP cord-267475-6f4h3cck 891 8 at at IN cord-267475-6f4h3cck 891 9 a a DT cord-267475-6f4h3cck 891 10 terminator terminator NN cord-267475-6f4h3cck 891 11 codon codon NN cord-267475-6f4h3cck 891 12 , , , cord-267475-6f4h3cck 891 13 in in IN cord-267475-6f4h3cck 891 14 order order NN cord-267475-6f4h3cck 891 15 to to TO cord-267475-6f4h3cck 891 16 reinitiate reinitiate VB cord-267475-6f4h3cck 891 17 ? ? . cord-267475-6f4h3cck 892 1 What what WP cord-267475-6f4h3cck 892 2 prevents prevent VBZ cord-267475-6f4h3cck 892 3 reinitiation reinitiation NN cord-267475-6f4h3cck 892 4 when when WRB cord-267475-6f4h3cck 892 5 the the DT cord-267475-6f4h3cck 892 6 size size NN cord-267475-6f4h3cck 892 7 of of IN cord-267475-6f4h3cck 892 8 the the DT cord-267475-6f4h3cck 892 9 first first JJ cord-267475-6f4h3cck 892 10 ORF ORF NNP cord-267475-6f4h3cck 892 11 exceeds exceed VBZ cord-267475-6f4h3cck 892 12 a a DT cord-267475-6f4h3cck 892 13 certain certain JJ cord-267475-6f4h3cck 892 14 length length NN cord-267475-6f4h3cck 892 15 ? ? . cord-267475-6f4h3cck 893 1 We -PRON- PRP cord-267475-6f4h3cck 893 2 know know VBP cord-267475-6f4h3cck 893 3 nothing nothing NN cord-267475-6f4h3cck 893 4 about about IN cord-267475-6f4h3cck 893 5 how how WRB cord-267475-6f4h3cck 893 6 recognition recognition NN cord-267475-6f4h3cck 893 7 of of IN cord-267475-6f4h3cck 893 8 the the DT cord-267475-6f4h3cck 893 9 start start NN cord-267475-6f4h3cck 893 10 codon codon NN cord-267475-6f4h3cck 893 11 is be VBZ cord-267475-6f4h3cck 893 12 aided aid VBN cord-267475-6f4h3cck 893 13 by by IN cord-267475-6f4h3cck 893 14 a a DT cord-267475-6f4h3cck 893 15 purine purine NN cord-267475-6f4h3cck 893 16 in in IN cord-267475-6f4h3cck 893 17 position position NN cord-267475-6f4h3cck 893 18 23 23 CD cord-267475-6f4h3cck 893 19 and and CC cord-267475-6f4h3cck 893 20 G g NN cord-267475-6f4h3cck 893 21 in in IN cord-267475-6f4h3cck 893 22 position position NN cord-267475-6f4h3cck 893 23 þ þ NNP cord-267475-6f4h3cck 893 24 4 4 CD cord-267475-6f4h3cck 893 25 . . . cord-267475-6f4h3cck 894 1 There there EX cord-267475-6f4h3cck 894 2 is be VBZ cord-267475-6f4h3cck 894 3 no no DT cord-267475-6f4h3cck 894 4 evidence evidence NN cord-267475-6f4h3cck 894 5 for for IN cord-267475-6f4h3cck 894 6 base base NN cord-267475-6f4h3cck 894 7 pairing pairing NN cord-267475-6f4h3cck 894 8 between between IN cord-267475-6f4h3cck 894 9 the the DT cord-267475-6f4h3cck 894 10 GCCRCC GCCRCC NNP cord-267475-6f4h3cck 894 11 motif motif NN cord-267475-6f4h3cck 894 12 and and CC cord-267475-6f4h3cck 894 13 rRNA rrna NN cord-267475-6f4h3cck 894 14 ( ( -LRB- cord-267475-6f4h3cck 894 15 or or CC cord-267475-6f4h3cck 894 16 for for IN cord-267475-6f4h3cck 894 17 binding bind VBG cord-267475-6f4h3cck 894 18 of of IN cord-267475-6f4h3cck 894 19 rRNA rrna NN cord-267475-6f4h3cck 894 20 to to IN cord-267475-6f4h3cck 894 21 any any DT cord-267475-6f4h3cck 894 22 other other JJ cord-267475-6f4h3cck 894 23 sequence sequence NN cord-267475-6f4h3cck 894 24 in in IN cord-267475-6f4h3cck 894 25 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 894 26 mRNAs mrnas CD cord-267475-6f4h3cck 894 27 ) ) -RRB- cord-267475-6f4h3cck 894 28 . . . cord-267475-6f4h3cck 895 1 There there EX cord-267475-6f4h3cck 895 2 is be VBZ cord-267475-6f4h3cck 895 3 as as RB cord-267475-6f4h3cck 895 4 yet yet RB cord-267475-6f4h3cck 895 5 no no DT cord-267475-6f4h3cck 895 6 convincing convincing JJ cord-267475-6f4h3cck 895 7 evidence evidence NN cord-267475-6f4h3cck 895 8 for for IN cord-267475-6f4h3cck 895 9 recognition recognition NN cord-267475-6f4h3cck 895 10 of of IN cord-267475-6f4h3cck 895 11 GCCRCC GCCRCC NNP cord-267475-6f4h3cck 895 12 by by IN cord-267475-6f4h3cck 895 13 a a DT cord-267475-6f4h3cck 895 14 trans trans JJ cord-267475-6f4h3cck 895 15 - - JJ cord-267475-6f4h3cck 895 16 acting acting JJ cord-267475-6f4h3cck 895 17 protein protein NN cord-267475-6f4h3cck 895 18 factor factor NN cord-267475-6f4h3cck 895 19 . . . cord-267475-6f4h3cck 896 1 It -PRON- PRP cord-267475-6f4h3cck 896 2 would would MD cord-267475-6f4h3cck 896 3 be be VB cord-267475-6f4h3cck 896 4 easy easy JJ cord-267475-6f4h3cck 896 5 , , , cord-267475-6f4h3cck 896 6 and and CC cord-267475-6f4h3cck 896 7 meaningless meaningless JJ cord-267475-6f4h3cck 896 8 , , , cord-267475-6f4h3cck 896 9 simply simply RB cord-267475-6f4h3cck 896 10 to to TO cord-267475-6f4h3cck 896 11 find find VB cord-267475-6f4h3cck 896 12 proteins protein NNS cord-267475-6f4h3cck 896 13 that that WDT cord-267475-6f4h3cck 896 14 bind bind VBP cord-267475-6f4h3cck 896 15 an an DT cord-267475-6f4h3cck 896 16 RNA RNA NNP cord-267475-6f4h3cck 896 17 fragment fragment NN cord-267475-6f4h3cck 896 18 which which WDT cord-267475-6f4h3cck 896 19 contains contain VBZ cord-267475-6f4h3cck 896 20 the the DT cord-267475-6f4h3cck 896 21 motif motif NN cord-267475-6f4h3cck 896 22 . . . cord-267475-6f4h3cck 897 1 Credible credible JJ cord-267475-6f4h3cck 897 2 experiments experiment NNS cord-267475-6f4h3cck 897 3 would would MD cord-267475-6f4h3cck 897 4 require require VB cord-267475-6f4h3cck 897 5 controls control NNS cord-267475-6f4h3cck 897 6 based base VBN cord-267475-6f4h3cck 897 7 on on IN cord-267475-6f4h3cck 897 8 what what WP cord-267475-6f4h3cck 897 9 we -PRON- PRP cord-267475-6f4h3cck 897 10 know know VBP cord-267475-6f4h3cck 897 11 about about IN cord-267475-6f4h3cck 897 12 the the DT cord-267475-6f4h3cck 897 13 consensus consensus NN cord-267475-6f4h3cck 897 14 sequence sequence NN cord-267475-6f4h3cck 897 15 : : : cord-267475-6f4h3cck 897 16 that that IN cord-267475-6f4h3cck 897 17 the the DT cord-267475-6f4h3cck 897 18 purine purine NN cord-267475-6f4h3cck 897 19 ( ( -LRB- cord-267475-6f4h3cck 897 20 A a NN cord-267475-6f4h3cck 897 21 . . . cord-267475-6f4h3cck 897 22 G g NN cord-267475-6f4h3cck 897 23 ) ) -RRB- cord-267475-6f4h3cck 897 24 in in IN cord-267475-6f4h3cck 897 25 position position NN cord-267475-6f4h3cck 897 26 2 2 CD cord-267475-6f4h3cck 897 27 3 3 CD cord-267475-6f4h3cck 897 28 plays play VBZ cord-267475-6f4h3cck 897 29 a a DT cord-267475-6f4h3cck 897 30 dominant dominant JJ cord-267475-6f4h3cck 897 31 role role NN cord-267475-6f4h3cck 897 32 , , , cord-267475-6f4h3cck 897 33 and and CC cord-267475-6f4h3cck 897 34 the the DT cord-267475-6f4h3cck 897 35 full full JJ cord-267475-6f4h3cck 897 36 effect effect NN cord-267475-6f4h3cck 897 37 requires require VBZ cord-267475-6f4h3cck 897 38 that that IN cord-267475-6f4h3cck 897 39 the the DT cord-267475-6f4h3cck 897 40 GCCRCC GCCRCC NNP cord-267475-6f4h3cck 897 41 motif motif NN cord-267475-6f4h3cck 897 42 abut abut IN cord-267475-6f4h3cck 897 43 the the DT cord-267475-6f4h3cck 897 44 AUG AUG NNP cord-267475-6f4h3cck 897 45 codon codon NN cord-267475-6f4h3cck 897 46 ( ( -LRB- cord-267475-6f4h3cck 897 47 Kozak Kozak NNP cord-267475-6f4h3cck 897 48 , , , cord-267475-6f4h3cck 897 49 1999 1999 CD cord-267475-6f4h3cck 897 50 , , , cord-267475-6f4h3cck 897 51 Fig Fig NNP cord-267475-6f4h3cck 897 52 . . NNP cord-267475-6f4h3cck 897 53 1 1 CD cord-267475-6f4h3cck 897 54 ) ) -RRB- cord-267475-6f4h3cck 897 55 . . . cord-267475-6f4h3cck 898 1 With with IN cord-267475-6f4h3cck 898 2 so so RB cord-267475-6f4h3cck 898 3 much much JJ cord-267475-6f4h3cck 898 4 effort effort NN cord-267475-6f4h3cck 898 5 being be VBG cord-267475-6f4h3cck 898 6 directed direct VBN cord-267475-6f4h3cck 898 7 to to IN cord-267475-6f4h3cck 898 8 searching search VBG cord-267475-6f4h3cck 898 9 for for IN cord-267475-6f4h3cck 898 10 possible possible JJ cord-267475-6f4h3cck 898 11 exceptions exception NNS cord-267475-6f4h3cck 898 12 to to IN cord-267475-6f4h3cck 898 13 the the DT cord-267475-6f4h3cck 898 14 scanning scanning NN cord-267475-6f4h3cck 898 15 mechanism mechanism NN cord-267475-6f4h3cck 898 16 , , , cord-267475-6f4h3cck 898 17 one one PRP cord-267475-6f4h3cck 898 18 can can MD cord-267475-6f4h3cck 898 19 only only RB cord-267475-6f4h3cck 898 20 wish wish VB cord-267475-6f4h3cck 898 21 that that IN cord-267475-6f4h3cck 898 22 some some DT cord-267475-6f4h3cck 898 23 enterprising enterprising JJ cord-267475-6f4h3cck 898 24 soul soul NN cord-267475-6f4h3cck 898 25 would would MD cord-267475-6f4h3cck 898 26 tackle tackle VB cord-267475-6f4h3cck 898 27 these these DT cord-267475-6f4h3cck 898 28 important important JJ cord-267475-6f4h3cck 898 29 questions question NNS cord-267475-6f4h3cck 898 30 . . . cord-267475-6f4h3cck 899 1 Interleukin-2-induced interleukin-2-induce VBN cord-267475-6f4h3cck 899 2 , , , cord-267475-6f4h3cck 899 3 melanoma melanoma NN cord-267475-6f4h3cck 899 4 - - HYPH cord-267475-6f4h3cck 899 5 specific specific JJ cord-267475-6f4h3cck 899 6 T t NN cord-267475-6f4h3cck 899 7 cells cell NNS cord-267475-6f4h3cck 899 8 recognize recognize VBP cord-267475-6f4h3cck 899 9 CAMEL camel NN cord-267475-6f4h3cck 899 10 , , , cord-267475-6f4h3cck 899 11 an an DT cord-267475-6f4h3cck 899 12 unexpected unexpected JJ cord-267475-6f4h3cck 899 13 translation translation NN cord-267475-6f4h3cck 899 14 product product NN cord-267475-6f4h3cck 899 15 of of IN cord-267475-6f4h3cck 899 16 LAGE-1 LAGE-1 NNP cord-267475-6f4h3cck 899 17 Suppression Suppression NNP cord-267475-6f4h3cck 899 18 of of IN cord-267475-6f4h3cck 899 19 ribosomal ribosomal JJ cord-267475-6f4h3cck 899 20 reinitiation reinitiation NN cord-267475-6f4h3cck 899 21 at at IN cord-267475-6f4h3cck 899 22 upstream upstream JJ cord-267475-6f4h3cck 899 23 open open JJ cord-267475-6f4h3cck 899 24 reading reading NN cord-267475-6f4h3cck 899 25 frames frame NNS cord-267475-6f4h3cck 899 26 in in IN cord-267475-6f4h3cck 899 27 amino amino JJ cord-267475-6f4h3cck 899 28 acid acid NN cord-267475-6f4h3cck 899 29 - - HYPH cord-267475-6f4h3cck 899 30 starved starve VBN cord-267475-6f4h3cck 899 31 cells cell NNS cord-267475-6f4h3cck 899 32 forms form VBZ cord-267475-6f4h3cck 899 33 the the DT cord-267475-6f4h3cck 899 34 basis basis NN cord-267475-6f4h3cck 899 35 for for IN cord-267475-6f4h3cck 899 36 GCN4 GCN4 NNP cord-267475-6f4h3cck 899 37 translational translational JJ cord-267475-6f4h3cck 899 38 control control NN cord-267475-6f4h3cck 900 1 Subcellular subcellular JJ cord-267475-6f4h3cck 900 2 fate fate NN cord-267475-6f4h3cck 900 3 of of IN cord-267475-6f4h3cck 900 4 the the DT cord-267475-6f4h3cck 900 5 Int-2 Int-2 NNP cord-267475-6f4h3cck 900 6 oncoprotein oncoprotein NNP cord-267475-6f4h3cck 900 7 is be VBZ cord-267475-6f4h3cck 900 8 determined determine VBN cord-267475-6f4h3cck 900 9 by by IN cord-267475-6f4h3cck 900 10 choice choice NN cord-267475-6f4h3cck 900 11 of of IN cord-267475-6f4h3cck 900 12 initiation initiation NN cord-267475-6f4h3cck 900 13 codon codon NN cord-267475-6f4h3cck 900 14 Kozak Kozak NNP cord-267475-6f4h3cck 900 15 sequence sequence NN cord-267475-6f4h3cck 900 16 polymorphism polymorphism NN cord-267475-6f4h3cck 900 17 of of IN cord-267475-6f4h3cck 900 18 the the DT cord-267475-6f4h3cck 900 19 glycoprotein glycoprotein NN cord-267475-6f4h3cck 900 20 ( ( -LRB- cord-267475-6f4h3cck 900 21 GP gp NN cord-267475-6f4h3cck 900 22 ) ) -RRB- cord-267475-6f4h3cck 901 1 Iba Iba NNP cord-267475-6f4h3cck 901 2 gene gene NN cord-267475-6f4h3cck 901 3 is be VBZ cord-267475-6f4h3cck 901 4 a a DT cord-267475-6f4h3cck 901 5 major major JJ cord-267475-6f4h3cck 901 6 determinant determinant NN cord-267475-6f4h3cck 901 7 of of IN cord-267475-6f4h3cck 901 8 the the DT cord-267475-6f4h3cck 901 9 plasma plasma NN cord-267475-6f4h3cck 901 10 membrane membrane NN cord-267475-6f4h3cck 901 11 levels level NNS cord-267475-6f4h3cck 901 12 of of IN cord-267475-6f4h3cck 901 13 the the DT cord-267475-6f4h3cck 901 14 platelet platelet NN cord-267475-6f4h3cck 902 1 GP GP NNP cord-267475-6f4h3cck 902 2 Ib Ib NNP cord-267475-6f4h3cck 902 3 - - HYPH cord-267475-6f4h3cck 902 4 IX IX NNP cord-267475-6f4h3cck 902 5 - - HYPH cord-267475-6f4h3cck 902 6 V V NNP cord-267475-6f4h3cck 902 7 complex complex JJ cord-267475-6f4h3cck 902 8 Specific specific JJ cord-267475-6f4h3cck 902 9 sequences sequence NNS cord-267475-6f4h3cck 902 10 in in IN cord-267475-6f4h3cck 902 11 p120ctn p120ctn NNP cord-267475-6f4h3cck 902 12 determine determine VB cord-267475-6f4h3cck 902 13 subcellular subcellular JJ cord-267475-6f4h3cck 902 14 distribution distribution NN cord-267475-6f4h3cck 902 15 of of IN cord-267475-6f4h3cck 902 16 its -PRON- PRP$ cord-267475-6f4h3cck 902 17 multiple multiple JJ cord-267475-6f4h3cck 902 18 isoforms isoform NNS cord-267475-6f4h3cck 902 19 involved involve VBN cord-267475-6f4h3cck 902 20 in in IN cord-267475-6f4h3cck 902 21 cellular cellular JJ cord-267475-6f4h3cck 902 22 adhesion adhesion NN cord-267475-6f4h3cck 902 23 of of IN cord-267475-6f4h3cck 902 24 normal normal JJ cord-267475-6f4h3cck 902 25 and and CC cord-267475-6f4h3cck 902 26 malignant malignant JJ cord-267475-6f4h3cck 902 27 epithelial epithelial JJ cord-267475-6f4h3cck 902 28 cells cell NNS cord-267475-6f4h3cck 903 1 Unconventional Unconventional NNP cord-267475-6f4h3cck 903 2 mRNA mRNA NNP cord-267475-6f4h3cck 903 3 processing process VBG cord-267475-6f4h3cck 903 4 in in IN cord-267475-6f4h3cck 903 5 the the DT cord-267475-6f4h3cck 903 6 expression expression NN cord-267475-6f4h3cck 903 7 of of IN cord-267475-6f4h3cck 903 8 two two CD cord-267475-6f4h3cck 903 9 calcineurin calcineurin NN cord-267475-6f4h3cck 903 10 B b NN cord-267475-6f4h3cck 903 11 isoforms isoform NNS cord-267475-6f4h3cck 903 12 in in IN cord-267475-6f4h3cck 903 13 Dictyostelium Dictyostelium NNP cord-267475-6f4h3cck 903 14 Uroporphyrinogen Uroporphyrinogen NNP cord-267475-6f4h3cck 903 15 III III NNP cord-267475-6f4h3cck 903 16 synthase synthase NN cord-267475-6f4h3cck 903 17 . . . cord-267475-6f4h3cck 904 1 An an DT cord-267475-6f4h3cck 904 2 alternative alternative JJ cord-267475-6f4h3cck 904 3 promoter promoter NN cord-267475-6f4h3cck 904 4 controls control VBZ cord-267475-6f4h3cck 904 5 erythroid erythroid NN cord-267475-6f4h3cck 904 6 - - HYPH cord-267475-6f4h3cck 904 7 specific specific JJ cord-267475-6f4h3cck 904 8 expression expression NN cord-267475-6f4h3cck 904 9 in in IN cord-267475-6f4h3cck 904 10 the the DT cord-267475-6f4h3cck 904 11 murine murine JJ cord-267475-6f4h3cck 904 12 gene gene NN cord-267475-6f4h3cck 904 13 Regulation regulation NN cord-267475-6f4h3cck 904 14 of of IN cord-267475-6f4h3cck 904 15 vascular vascular JJ cord-267475-6f4h3cck 904 16 endothelial endothelial JJ cord-267475-6f4h3cck 904 17 growth growth NN cord-267475-6f4h3cck 904 18 factor factor NN cord-267475-6f4h3cck 905 1 ( ( -LRB- cord-267475-6f4h3cck 905 2 VEGF VEGF NNP cord-267475-6f4h3cck 905 3 ) ) -RRB- cord-267475-6f4h3cck 905 4 expression expression NN cord-267475-6f4h3cck 905 5 is be VBZ cord-267475-6f4h3cck 905 6 mediated mediate VBN cord-267475-6f4h3cck 905 7 by by IN cord-267475-6f4h3cck 905 8 internal internal JJ cord-267475-6f4h3cck 905 9 initiation initiation NN cord-267475-6f4h3cck 905 10 of of IN cord-267475-6f4h3cck 905 11 translation translation NN cord-267475-6f4h3cck 905 12 and and CC cord-267475-6f4h3cck 905 13 alternative alternative JJ cord-267475-6f4h3cck 905 14 initiation initiation NN cord-267475-6f4h3cck 905 15 of of IN cord-267475-6f4h3cck 905 16 transcription transcription NN cord-267475-6f4h3cck 905 17 Abundant abundant JJ cord-267475-6f4h3cck 905 18 early early JJ cord-267475-6f4h3cck 905 19 expression expression NN cord-267475-6f4h3cck 905 20 of of IN cord-267475-6f4h3cck 905 21 gpUL4 gpUL4 NNP cord-267475-6f4h3cck 905 22 from from IN cord-267475-6f4h3cck 905 23 a a DT cord-267475-6f4h3cck 905 24 human human JJ cord-267475-6f4h3cck 905 25 cytomegalovirus cytomegalovirus NN cord-267475-6f4h3cck 905 26 mutant mutant NN cord-267475-6f4h3cck 905 27 lacking lack VBG cord-267475-6f4h3cck 905 28 a a DT cord-267475-6f4h3cck 905 29 repressive repressive JJ cord-267475-6f4h3cck 905 30 upstream upstream NN cord-267475-6f4h3cck 905 31 open open JJ cord-267475-6f4h3cck 905 32 reading reading NN cord-267475-6f4h3cck 905 33 frame frame NN cord-267475-6f4h3cck 905 34 Apobec-1 Apobec-1 NNP cord-267475-6f4h3cck 905 35 transcription transcription NN cord-267475-6f4h3cck 905 36 in in IN cord-267475-6f4h3cck 905 37 rat rat NN cord-267475-6f4h3cck 905 38 colon colon NN cord-267475-6f4h3cck 905 39 cancer cancer NN cord-267475-6f4h3cck 905 40 : : : cord-267475-6f4h3cck 905 41 decreased decrease VBD cord-267475-6f4h3cck 905 42 apobec-1 apobec-1 NNP cord-267475-6f4h3cck 905 43 protein protein NN cord-267475-6f4h3cck 905 44 production production NN cord-267475-6f4h3cck 905 45 through through IN cord-267475-6f4h3cck 905 46 alterations alteration NNS cord-267475-6f4h3cck 905 47 in in IN cord-267475-6f4h3cck 905 48 polysome polysome NN cord-267475-6f4h3cck 905 49 distribution distribution NN cord-267475-6f4h3cck 905 50 and and CC cord-267475-6f4h3cck 905 51 mRNA mrna NN cord-267475-6f4h3cck 905 52 translation translation NN cord-267475-6f4h3cck 905 53 associated associate VBN cord-267475-6f4h3cck 905 54 with with IN cord-267475-6f4h3cck 905 55 upstream upstream JJ cord-267475-6f4h3cck 905 56 AUGs aug NNS cord-267475-6f4h3cck 905 57 Identification identification NN cord-267475-6f4h3cck 905 58 of of IN cord-267475-6f4h3cck 905 59 a a DT cord-267475-6f4h3cck 905 60 brain brain NN cord-267475-6f4h3cck 905 61 - - HYPH cord-267475-6f4h3cck 905 62 specific specific JJ cord-267475-6f4h3cck 905 63 protein protein NN cord-267475-6f4h3cck 905 64 kinase kinase NN cord-267475-6f4h3cck 905 65 Cj Cj NNP cord-267475-6f4h3cck 905 66 pseudogene pseudogene NN cord-267475-6f4h3cck 905 67 ( ( -LRB- cord-267475-6f4h3cck 906 1 CPKCj CPKCj NNP cord-267475-6f4h3cck 906 2 ) ) -RRB- cord-267475-6f4h3cck 906 3 transcript transcript NN cord-267475-6f4h3cck 906 4 Tissue tissue NN cord-267475-6f4h3cck 906 5 - - HYPH cord-267475-6f4h3cck 906 6 specific specific JJ cord-267475-6f4h3cck 906 7 and and CC cord-267475-6f4h3cck 906 8 ubiquitous ubiquitous JJ cord-267475-6f4h3cck 906 9 promoters promoter NNS cord-267475-6f4h3cck 906 10 direct direct VBP cord-267475-6f4h3cck 906 11 the the DT cord-267475-6f4h3cck 906 12 expression expression NN cord-267475-6f4h3cck 906 13 of of IN cord-267475-6f4h3cck 906 14 alternatively alternatively RB cord-267475-6f4h3cck 906 15 spliced splice VBN cord-267475-6f4h3cck 906 16 transcripts transcript NNS cord-267475-6f4h3cck 906 17 from from IN cord-267475-6f4h3cck 906 18 the the DT cord-267475-6f4h3cck 906 19 calcitonin calcitonin NN cord-267475-6f4h3cck 906 20 receptor receptor NN cord-267475-6f4h3cck 906 21 gene gene NN cord-267475-6f4h3cck 906 22 Structural structural JJ cord-267475-6f4h3cck 906 23 characterization characterization NN cord-267475-6f4h3cck 906 24 of of IN cord-267475-6f4h3cck 906 25 SIL SIL NNP cord-267475-6f4h3cck 906 26 , , , cord-267475-6f4h3cck 906 27 a a DT cord-267475-6f4h3cck 906 28 gene gene NN cord-267475-6f4h3cck 906 29 frequently frequently RB cord-267475-6f4h3cck 906 30 disrupted disrupt VBD cord-267475-6f4h3cck 906 31 in in IN cord-267475-6f4h3cck 906 32 T t NN cord-267475-6f4h3cck 906 33 - - HYPH cord-267475-6f4h3cck 906 34 cell cell NN cord-267475-6f4h3cck 906 35 acute acute JJ cord-267475-6f4h3cck 906 36 lymphoblastic lymphoblastic JJ cord-267475-6f4h3cck 906 37 leukemia leukemia NN cord-267475-6f4h3cck 906 38 Cloning cloning NN cord-267475-6f4h3cck 906 39 and and CC cord-267475-6f4h3cck 906 40 characterization characterization NN cord-267475-6f4h3cck 906 41 of of IN cord-267475-6f4h3cck 906 42 the the DT cord-267475-6f4h3cck 906 43 gene gene NN cord-267475-6f4h3cck 906 44 encoding encode VBG cord-267475-6f4h3cck 906 45 rabbit rabbit NN cord-267475-6f4h3cck 906 46 cardiac cardiac FW cord-267475-6f4h3cck 906 47 calsequestrin calsequestrin NNP cord-267475-6f4h3cck 907 1 A a DT cord-267475-6f4h3cck 907 2 new new JJ cord-267475-6f4h3cck 907 3 34-kilodalton 34-kilodalton CD cord-267475-6f4h3cck 907 4 isoform isoform NN cord-267475-6f4h3cck 907 5 of of IN cord-267475-6f4h3cck 907 6 human human JJ cord-267475-6f4h3cck 907 7 fibroblast fibroblast NN cord-267475-6f4h3cck 907 8 growth growth NN cord-267475-6f4h3cck 907 9 factor factor NN cord-267475-6f4h3cck 907 10 2 2 CD cord-267475-6f4h3cck 907 11 is be VBZ cord-267475-6f4h3cck 907 12 cap cap NN cord-267475-6f4h3cck 907 13 dependently dependently RB cord-267475-6f4h3cck 907 14 synthesized synthesize VBN cord-267475-6f4h3cck 907 15 by by IN cord-267475-6f4h3cck 907 16 using use VBG cord-267475-6f4h3cck 907 17 a a DT cord-267475-6f4h3cck 907 18 non non JJ cord-267475-6f4h3cck 907 19 - - JJ cord-267475-6f4h3cck 907 20 AUG AUG NNP cord-267475-6f4h3cck 907 21 start start NN cord-267475-6f4h3cck 907 22 codon codon NN cord-267475-6f4h3cck 907 23 and and CC cord-267475-6f4h3cck 907 24 behaves behave VBZ cord-267475-6f4h3cck 907 25 as as IN cord-267475-6f4h3cck 907 26 a a DT cord-267475-6f4h3cck 907 27 survival survival NN cord-267475-6f4h3cck 907 28 factor factor NN cord-267475-6f4h3cck 907 29 Inhibition inhibition NN cord-267475-6f4h3cck 907 30 of of IN cord-267475-6f4h3cck 907 31 translation translation NN cord-267475-6f4h3cck 907 32 of of IN cord-267475-6f4h3cck 907 33 transforming transform VBG cord-267475-6f4h3cck 907 34 growth growth NN cord-267475-6f4h3cck 907 35 factor factor NN cord-267475-6f4h3cck 907 36 - - HYPH cord-267475-6f4h3cck 907 37 b3 b3 NN cord-267475-6f4h3cck 908 1 mRNA mRNA NNP cord-267475-6f4h3cck 908 2 by by IN cord-267475-6f4h3cck 908 3 its -PRON- PRP$ cord-267475-6f4h3cck 908 4 5 5 CD cord-267475-6f4h3cck 908 5 0 0 CD cord-267475-6f4h3cck 908 6 untranslated untranslated JJ cord-267475-6f4h3cck 908 7 region region NN cord-267475-6f4h3cck 909 1 Enhanced enhance VBN cord-267475-6f4h3cck 909 2 translational translational JJ cord-267475-6f4h3cck 909 3 efficiency efficiency NN cord-267475-6f4h3cck 909 4 of of IN cord-267475-6f4h3cck 909 5 a a DT cord-267475-6f4h3cck 909 6 novel novel JJ cord-267475-6f4h3cck 909 7 transforming transform VBG cord-267475-6f4h3cck 909 8 growth growth NN cord-267475-6f4h3cck 909 9 factor factor NN cord-267475-6f4h3cck 909 10 b3 b3 NNP cord-267475-6f4h3cck 909 11 mRNA mrna NN cord-267475-6f4h3cck 909 12 in in IN cord-267475-6f4h3cck 909 13 human human JJ cord-267475-6f4h3cck 909 14 breast breast NN cord-267475-6f4h3cck 909 15 cancer cancer NN cord-267475-6f4h3cck 909 16 cells cell NNS cord-267475-6f4h3cck 910 1 Translational translational JJ cord-267475-6f4h3cck 910 2 initiation initiation NN cord-267475-6f4h3cck 910 3 competence competence NN cord-267475-6f4h3cck 910 4 , , , cord-267475-6f4h3cck 910 5 ' ' '' cord-267475-6f4h3cck 910 6 leaky leaky JJ cord-267475-6f4h3cck 910 7 scanning scanning NN cord-267475-6f4h3cck 910 8 ' ' '' cord-267475-6f4h3cck 910 9 and and CC cord-267475-6f4h3cck 910 10 translational translational JJ cord-267475-6f4h3cck 910 11 reinitiation reinitiation NN cord-267475-6f4h3cck 910 12 in in IN cord-267475-6f4h3cck 910 13 areA areA NNP cord-267475-6f4h3cck 910 14 mRNA mrna NN cord-267475-6f4h3cck 910 15 of of IN cord-267475-6f4h3cck 910 16 Aspergillus Aspergillus NNP cord-267475-6f4h3cck 910 17 nidulans nidulan VBZ cord-267475-6f4h3cck 910 18 Multiple multiple JJ cord-267475-6f4h3cck 910 19 roles role NNS cord-267475-6f4h3cck 910 20 for for IN cord-267475-6f4h3cck 910 21 the the DT cord-267475-6f4h3cck 910 22 Cterminal Cterminal NNP cord-267475-6f4h3cck 910 23 domain domain NN cord-267475-6f4h3cck 910 24 of of IN cord-267475-6f4h3cck 910 25 eIF5 eif5 NN cord-267475-6f4h3cck 911 1 in in IN cord-267475-6f4h3cck 911 2 translation translation NN cord-267475-6f4h3cck 911 3 initiation initiation NN cord-267475-6f4h3cck 911 4 complex complex JJ cord-267475-6f4h3cck 911 5 assembly assembly NN cord-267475-6f4h3cck 911 6 and and CC cord-267475-6f4h3cck 912 1 GTPase GTPase NNP cord-267475-6f4h3cck 912 2 activation activation NN cord-267475-6f4h3cck 912 3 Biosynthesis Biosynthesis NNP cord-267475-6f4h3cck 912 4 of of IN cord-267475-6f4h3cck 912 5 osteogenic osteogenic NNP cord-267475-6f4h3cck 912 6 growth growth NN cord-267475-6f4h3cck 912 7 peptide peptide NN cord-267475-6f4h3cck 912 8 via via IN cord-267475-6f4h3cck 912 9 alternative alternative JJ cord-267475-6f4h3cck 912 10 translational translational JJ cord-267475-6f4h3cck 912 11 initiation initiation NN cord-267475-6f4h3cck 912 12 at at IN cord-267475-6f4h3cck 912 13 AUG AUG NNP cord-267475-6f4h3cck 912 14 85 85 CD cord-267475-6f4h3cck 912 15 of of IN cord-267475-6f4h3cck 912 16 histone histone NN cord-267475-6f4h3cck 912 17 H4 H4 NNP cord-267475-6f4h3cck 912 18 mRNA mRNA NNP cord-267475-6f4h3cck 912 19 Expression expression NN cord-267475-6f4h3cck 912 20 of of IN cord-267475-6f4h3cck 912 21 murine murine JJ cord-267475-6f4h3cck 912 22 IL-12 IL-12 NNP cord-267475-6f4h3cck 912 23 is be VBZ cord-267475-6f4h3cck 912 24 regulated regulate VBN cord-267475-6f4h3cck 912 25 by by IN cord-267475-6f4h3cck 912 26 translational translational JJ cord-267475-6f4h3cck 912 27 control control NN cord-267475-6f4h3cck 912 28 of of IN cord-267475-6f4h3cck 912 29 the the DT cord-267475-6f4h3cck 912 30 p35 p35 CD cord-267475-6f4h3cck 912 31 subunit subunit NN cord-267475-6f4h3cck 913 1 The the DT cord-267475-6f4h3cck 913 2 two two CD cord-267475-6f4h3cck 913 3 proteins protein NNS cord-267475-6f4h3cck 913 4 encoded encode VBN cord-267475-6f4h3cck 913 5 by by IN cord-267475-6f4h3cck 913 6 the the DT cord-267475-6f4h3cck 913 7 cottontail cottontail NN cord-267475-6f4h3cck 913 8 rabbit rabbit NN cord-267475-6f4h3cck 913 9 papillomavirus papillomavirus NN cord-267475-6f4h3cck 913 10 E6 e6 NN cord-267475-6f4h3cck 913 11 open open JJ cord-267475-6f4h3cck 913 12 reading reading NN cord-267475-6f4h3cck 913 13 frame frame NN cord-267475-6f4h3cck 913 14 differ differ VBP cord-267475-6f4h3cck 913 15 with with IN cord-267475-6f4h3cck 913 16 respect respect NN cord-267475-6f4h3cck 913 17 to to IN cord-267475-6f4h3cck 913 18 localization localization NN cord-267475-6f4h3cck 913 19 and and CC cord-267475-6f4h3cck 913 20 phosphorylation phosphorylation NN cord-267475-6f4h3cck 913 21 Biosynthesis Biosynthesis NNP cord-267475-6f4h3cck 913 22 of of IN cord-267475-6f4h3cck 913 23 human human JJ cord-267475-6f4h3cck 913 24 fibroblast fibroblast NN cord-267475-6f4h3cck 913 25 growth growth NN cord-267475-6f4h3cck 913 26 factor-5 factor-5 NNP cord-267475-6f4h3cck 913 27 Novel novel JJ cord-267475-6f4h3cck 913 28 products product NNS cord-267475-6f4h3cck 913 29 of of IN cord-267475-6f4h3cck 913 30 the the DT cord-267475-6f4h3cck 913 31 HUD HUD NNP cord-267475-6f4h3cck 913 32 , , , cord-267475-6f4h3cck 913 33 HUC HUC NNP cord-267475-6f4h3cck 913 34 , , , cord-267475-6f4h3cck 913 35 NNP-1 NNP-1 NNP cord-267475-6f4h3cck 913 36 and and CC cord-267475-6f4h3cck 913 37 a a DT cord-267475-6f4h3cck 913 38 - - HYPH cord-267475-6f4h3cck 913 39 INTERNEXIN INTERNEXIN NNP cord-267475-6f4h3cck 913 40 genes gene NNS cord-267475-6f4h3cck 913 41 identified identify VBN cord-267475-6f4h3cck 913 42 by by IN cord-267475-6f4h3cck 913 43 autologous autologous JJ cord-267475-6f4h3cck 913 44 antibody antibody NN cord-267475-6f4h3cck 913 45 screening screening NN cord-267475-6f4h3cck 913 46 of of IN cord-267475-6f4h3cck 913 47 a a DT cord-267475-6f4h3cck 913 48 pediatric pediatric JJ cord-267475-6f4h3cck 913 49 neuroblastoma neuroblastoma NN cord-267475-6f4h3cck 913 50 library library NN cord-267475-6f4h3cck 913 51 Yeast Yeast NNP cord-267475-6f4h3cck 913 52 LEU4 LEU4 NNP cord-267475-6f4h3cck 913 53 encodes encode VBZ cord-267475-6f4h3cck 913 54 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 913 55 and and CC cord-267475-6f4h3cck 913 56 non non JJ cord-267475-6f4h3cck 913 57 - - JJ cord-267475-6f4h3cck 913 58 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 913 59 forms form NNS cord-267475-6f4h3cck 913 60 of of IN cord-267475-6f4h3cck 913 61 a a DT cord-267475-6f4h3cck 913 62 - - HYPH cord-267475-6f4h3cck 913 63 isopropylmalate isopropylmalate NN cord-267475-6f4h3cck 913 64 synthase synthase NN cord-267475-6f4h3cck 913 65 Mutation Mutation NNP cord-267475-6f4h3cck 913 66 creates create VBZ cord-267475-6f4h3cck 913 67 an an DT cord-267475-6f4h3cck 913 68 open open JJ cord-267475-6f4h3cck 913 69 reading reading NN cord-267475-6f4h3cck 913 70 frame frame NN cord-267475-6f4h3cck 913 71 within within IN cord-267475-6f4h3cck 913 72 the the DT cord-267475-6f4h3cck 913 73 5 5 CD cord-267475-6f4h3cck 913 74 0 0 CD cord-267475-6f4h3cck 913 75 untranslated untranslated JJ cord-267475-6f4h3cck 913 76 region region NN cord-267475-6f4h3cck 913 77 of of IN cord-267475-6f4h3cck 913 78 macaque macaque NN cord-267475-6f4h3cck 913 79 erythrocyte erythrocyte NN cord-267475-6f4h3cck 913 80 carbonic carbonic JJ cord-267475-6f4h3cck 913 81 anhydrase anhydrase NN cord-267475-6f4h3cck 913 82 ( ( -LRB- cord-267475-6f4h3cck 913 83 CA CA NNP cord-267475-6f4h3cck 913 84 ) ) -RRB- cord-267475-6f4h3cck 914 1 I -PRON- PRP cord-267475-6f4h3cck 915 1 mRNA mrna NN cord-267475-6f4h3cck 915 2 that that WDT cord-267475-6f4h3cck 915 3 suppresses suppress VBZ cord-267475-6f4h3cck 915 4 CA CA NNP cord-267475-6f4h3cck 916 1 I -PRON- PRP cord-267475-6f4h3cck 916 2 expression expression NN cord-267475-6f4h3cck 916 3 and and CC cord-267475-6f4h3cck 916 4 supports support VBZ cord-267475-6f4h3cck 916 5 the the DT cord-267475-6f4h3cck 916 6 scanning scanning NN cord-267475-6f4h3cck 916 7 model model NN cord-267475-6f4h3cck 916 8 for for IN cord-267475-6f4h3cck 916 9 translation translation NN cord-267475-6f4h3cck 917 1 The the DT cord-267475-6f4h3cck 917 2 translational translational JJ cord-267475-6f4h3cck 917 3 repression repression NN cord-267475-6f4h3cck 917 4 mediated mediate VBN cord-267475-6f4h3cck 917 5 by by IN cord-267475-6f4h3cck 917 6 the the DT cord-267475-6f4h3cck 917 7 platelet platelet NN cord-267475-6f4h3cck 917 8 - - HYPH cord-267475-6f4h3cck 917 9 derived derive VBN cord-267475-6f4h3cck 917 10 growth growth NN cord-267475-6f4h3cck 917 11 factor factor NN cord-267475-6f4h3cck 918 1 2 2 LS cord-267475-6f4h3cck 918 2 / / SYM cord-267475-6f4h3cck 918 3 c c NNP cord-267475-6f4h3cck 918 4 - - HYPH cord-267475-6f4h3cck 918 5 sis sis NNP cord-267475-6f4h3cck 918 6 mRNA mRNA NNP cord-267475-6f4h3cck 918 7 leader leader NN cord-267475-6f4h3cck 918 8 is be VBZ cord-267475-6f4h3cck 918 9 relieved relieve VBN cord-267475-6f4h3cck 918 10 during during IN cord-267475-6f4h3cck 918 11 megakaryocytic megakaryocytic JJ cord-267475-6f4h3cck 918 12 differentiation differentiation NN cord-267475-6f4h3cck 918 13 Positive positive JJ cord-267475-6f4h3cck 918 14 and and CC cord-267475-6f4h3cck 918 15 negative negative JJ cord-267475-6f4h3cck 918 16 regulation regulation NN cord-267475-6f4h3cck 918 17 of of IN cord-267475-6f4h3cck 918 18 myogenic myogenic JJ cord-267475-6f4h3cck 918 19 differentiation differentiation NN cord-267475-6f4h3cck 918 20 of of IN cord-267475-6f4h3cck 918 21 C2C12 c2c12 JJ cord-267475-6f4h3cck 918 22 cells cell NNS cord-267475-6f4h3cck 918 23 by by IN cord-267475-6f4h3cck 918 24 isoforms isoform NNS cord-267475-6f4h3cck 918 25 of of IN cord-267475-6f4h3cck 918 26 the the DT cord-267475-6f4h3cck 918 27 multiple multiple JJ cord-267475-6f4h3cck 918 28 homeodomain homeodomain NNP cord-267475-6f4h3cck 918 29 zinc zinc NN cord-267475-6f4h3cck 918 30 finger finger NN cord-267475-6f4h3cck 918 31 transcription transcription NN cord-267475-6f4h3cck 918 32 factor factor NN cord-267475-6f4h3cck 919 1 ATBF1 ATBF1 NNP cord-267475-6f4h3cck 919 2 Mechanism Mechanism NNP cord-267475-6f4h3cck 919 3 of of IN cord-267475-6f4h3cck 919 4 endoplasmic endoplasmic NN cord-267475-6f4h3cck 919 5 reticulum reticulum NN cord-267475-6f4h3cck 919 6 retention retention NN cord-267475-6f4h3cck 919 7 of of IN cord-267475-6f4h3cck 919 8 mutant mutant JJ cord-267475-6f4h3cck 919 9 vasopressin vasopressin NN cord-267475-6f4h3cck 919 10 precursor precursor NN cord-267475-6f4h3cck 919 11 caused cause VBN cord-267475-6f4h3cck 919 12 by by IN cord-267475-6f4h3cck 919 13 a a DT cord-267475-6f4h3cck 919 14 signal signal JJ cord-267475-6f4h3cck 919 15 peptide peptide NN cord-267475-6f4h3cck 919 16 truncation truncation NN cord-267475-6f4h3cck 919 17 associated associate VBN cord-267475-6f4h3cck 919 18 with with IN cord-267475-6f4h3cck 919 19 diabetes diabetes NN cord-267475-6f4h3cck 919 20 insipidus insipidus NN cord-267475-6f4h3cck 919 21 Alternative alternative JJ cord-267475-6f4h3cck 919 22 splicing splicing NN cord-267475-6f4h3cck 919 23 of of IN cord-267475-6f4h3cck 919 24 the the DT cord-267475-6f4h3cck 919 25 imprinted imprint VBN cord-267475-6f4h3cck 919 26 candidate candidate NN cord-267475-6f4h3cck 919 27 tumor tumor NN cord-267475-6f4h3cck 919 28 suppressor suppressor NN cord-267475-6f4h3cck 919 29 gene gene NN cord-267475-6f4h3cck 919 30 ZAC ZAC NNP cord-267475-6f4h3cck 919 31 regulates regulate VBZ cord-267475-6f4h3cck 919 32 its -PRON- PRP$ cord-267475-6f4h3cck 919 33 antiproliferative antiproliferative JJ cord-267475-6f4h3cck 919 34 and and CC cord-267475-6f4h3cck 919 35 DNA dna NN cord-267475-6f4h3cck 919 36 binding binding NN cord-267475-6f4h3cck 919 37 activities activity NNS cord-267475-6f4h3cck 920 1 A a DT cord-267475-6f4h3cck 920 2 global global JJ cord-267475-6f4h3cck 920 3 analysis analysis NN cord-267475-6f4h3cck 920 4 of of IN cord-267475-6f4h3cck 920 5 Caenorhabditis Caenorhabditis NNP cord-267475-6f4h3cck 920 6 elegans elegan NNS cord-267475-6f4h3cck 920 7 operons operon NNS cord-267475-6f4h3cck 921 1 The the DT cord-267475-6f4h3cck 921 2 avian avian JJ cord-267475-6f4h3cck 921 3 reovirus reovirus NN cord-267475-6f4h3cck 921 4 genome genome NN cord-267475-6f4h3cck 921 5 segment segment NN cord-267475-6f4h3cck 921 6 S1 S1 NNP cord-267475-6f4h3cck 921 7 is be VBZ cord-267475-6f4h3cck 921 8 a a DT cord-267475-6f4h3cck 921 9 functionally functionally RB cord-267475-6f4h3cck 921 10 tricistronic tricistronic JJ cord-267475-6f4h3cck 921 11 gene gene NN cord-267475-6f4h3cck 921 12 that that WDT cord-267475-6f4h3cck 921 13 expresses express VBZ cord-267475-6f4h3cck 921 14 one one CD cord-267475-6f4h3cck 921 15 structural structural JJ cord-267475-6f4h3cck 921 16 and and CC cord-267475-6f4h3cck 921 17 two two CD cord-267475-6f4h3cck 921 18 nonstructural nonstructural JJ cord-267475-6f4h3cck 921 19 proteins protein NNS cord-267475-6f4h3cck 921 20 in in IN cord-267475-6f4h3cck 921 21 infected infected JJ cord-267475-6f4h3cck 921 22 cells cell NNS cord-267475-6f4h3cck 922 1 The the DT cord-267475-6f4h3cck 922 2 2.2 2.2 CD cord-267475-6f4h3cck 922 3 kb kb NNP cord-267475-6f4h3cck 922 4 E1b E1b NNP cord-267475-6f4h3cck 922 5 mRNA mrna NN cord-267475-6f4h3cck 922 6 of of IN cord-267475-6f4h3cck 922 7 human human NN cord-267475-6f4h3cck 923 1 Ad12 Ad12 NNP cord-267475-6f4h3cck 923 2 and and CC cord-267475-6f4h3cck 923 3 Ad5 Ad5 NNP cord-267475-6f4h3cck 923 4 codes code NNS cord-267475-6f4h3cck 923 5 for for IN cord-267475-6f4h3cck 923 6 two two CD cord-267475-6f4h3cck 923 7 tumor tumor NN cord-267475-6f4h3cck 923 8 antigens antigen NNS cord-267475-6f4h3cck 923 9 starting start VBG cord-267475-6f4h3cck 923 10 at at IN cord-267475-6f4h3cck 923 11 different different JJ cord-267475-6f4h3cck 923 12 AUG AUG NNP cord-267475-6f4h3cck 923 13 triplets triplet NNS cord-267475-6f4h3cck 924 1 The the DT cord-267475-6f4h3cck 924 2 human human JJ cord-267475-6f4h3cck 924 3 tryptophan tryptophan NN cord-267475-6f4h3cck 924 4 hydroxylase hydroxylase NN cord-267475-6f4h3cck 924 5 gene gene NN cord-267475-6f4h3cck 924 6 . . . cord-267475-6f4h3cck 925 1 An an DT cord-267475-6f4h3cck 925 2 unusual unusual JJ cord-267475-6f4h3cck 925 3 splicing splicing NN cord-267475-6f4h3cck 925 4 complexity complexity NN cord-267475-6f4h3cck 925 5 in in IN cord-267475-6f4h3cck 925 6 the the DT cord-267475-6f4h3cck 925 7 5 5 CD cord-267475-6f4h3cck 925 8 0 0 CD cord-267475-6f4h3cck 925 9 -untranslated -untranslated JJ cord-267475-6f4h3cck 925 10 region region NN cord-267475-6f4h3cck 925 11 Mass Mass NNP cord-267475-6f4h3cck 925 12 spectrometric spectrometric JJ cord-267475-6f4h3cck 925 13 analysis analysis NN cord-267475-6f4h3cck 925 14 of of IN cord-267475-6f4h3cck 925 15 the the DT cord-267475-6f4h3cck 925 16 N n CD cord-267475-6f4h3cck 925 17 terminus terminus NN cord-267475-6f4h3cck 925 18 of of IN cord-267475-6f4h3cck 925 19 translational translational JJ cord-267475-6f4h3cck 925 20 initiation initiation NN cord-267475-6f4h3cck 925 21 factor factor NN cord-267475-6f4h3cck 926 1 eIF4G-1 eIF4G-1 NNP cord-267475-6f4h3cck 926 2 reveals reveal VBZ cord-267475-6f4h3cck 926 3 novel novel JJ cord-267475-6f4h3cck 926 4 isoforms isoform NNS cord-267475-6f4h3cck 927 1 The the DT cord-267475-6f4h3cck 927 2 procaspase-8 procaspase-8 NNP cord-267475-6f4h3cck 927 3 isoform isoform NN cord-267475-6f4h3cck 927 4 , , , cord-267475-6f4h3cck 927 5 procaspase-8L procaspase-8L NNP cord-267475-6f4h3cck 927 6 , , , cord-267475-6f4h3cck 927 7 recruited recruit VBN cord-267475-6f4h3cck 927 8 to to IN cord-267475-6f4h3cck 927 9 the the DT cord-267475-6f4h3cck 927 10 BAP31 BAP31 NNP cord-267475-6f4h3cck 927 11 complex complex NN cord-267475-6f4h3cck 927 12 at at IN cord-267475-6f4h3cck 927 13 the the DT cord-267475-6f4h3cck 927 14 endoplasmic endoplasmic NN cord-267475-6f4h3cck 927 15 reticulum reticulum NN cord-267475-6f4h3cck 927 16 Bunyamwera Bunyamwera NNP cord-267475-6f4h3cck 927 17 bunyavirus bunyavirus JJ cord-267475-6f4h3cck 927 18 nonstructural nonstructural JJ cord-267475-6f4h3cck 927 19 protein protein NN cord-267475-6f4h3cck 927 20 NSs NSs NNP cord-267475-6f4h3cck 927 21 is be VBZ cord-267475-6f4h3cck 927 22 a a DT cord-267475-6f4h3cck 927 23 nonessential nonessential JJ cord-267475-6f4h3cck 927 24 gene gene NN cord-267475-6f4h3cck 927 25 product product NN cord-267475-6f4h3cck 927 26 that that WDT cord-267475-6f4h3cck 927 27 contributes contribute VBZ cord-267475-6f4h3cck 927 28 to to IN cord-267475-6f4h3cck 927 29 viral viral JJ cord-267475-6f4h3cck 927 30 pathogenesis pathogenesis NN cord-267475-6f4h3cck 927 31 Role role NN cord-267475-6f4h3cck 927 32 of of IN cord-267475-6f4h3cck 927 33 two two CD cord-267475-6f4h3cck 927 34 upstream upstream RB cord-267475-6f4h3cck 927 35 open open JJ cord-267475-6f4h3cck 927 36 reading reading NN cord-267475-6f4h3cck 927 37 frames frame NNS cord-267475-6f4h3cck 927 38 in in IN cord-267475-6f4h3cck 927 39 the the DT cord-267475-6f4h3cck 927 40 translational translational JJ cord-267475-6f4h3cck 927 41 control control NN cord-267475-6f4h3cck 927 42 of of IN cord-267475-6f4h3cck 927 43 oncogene oncogene NN cord-267475-6f4h3cck 927 44 mdm2 mdm2 NN cord-267475-6f4h3cck 927 45 Microarray Microarray NNP cord-267475-6f4h3cck 927 46 identification identification NN cord-267475-6f4h3cck 927 47 of of IN cord-267475-6f4h3cck 927 48 FMRP FMRP NNP cord-267475-6f4h3cck 927 49 - - HYPH cord-267475-6f4h3cck 927 50 associated associate VBN cord-267475-6f4h3cck 927 51 brain brain NN cord-267475-6f4h3cck 927 52 mRNAs mrna VBD cord-267475-6f4h3cck 927 53 and and CC cord-267475-6f4h3cck 927 54 altered alter VBD cord-267475-6f4h3cck 927 55 mRNA mRNA NNP cord-267475-6f4h3cck 927 56 translational translational JJ cord-267475-6f4h3cck 927 57 profiles profile NNS cord-267475-6f4h3cck 927 58 in in IN cord-267475-6f4h3cck 927 59 fragile fragile JJ cord-267475-6f4h3cck 927 60 X x NN cord-267475-6f4h3cck 927 61 syndrome syndrome NN cord-267475-6f4h3cck 927 62 Identification identification NN cord-267475-6f4h3cck 927 63 of of IN cord-267475-6f4h3cck 927 64 a a DT cord-267475-6f4h3cck 927 65 novel novel JJ cord-267475-6f4h3cck 927 66 RNA rna NN cord-267475-6f4h3cck 927 67 splicing splicing NN cord-267475-6f4h3cck 927 68 pattern pattern NN cord-267475-6f4h3cck 927 69 as as IN cord-267475-6f4h3cck 927 70 a a DT cord-267475-6f4h3cck 927 71 basis basis NN cord-267475-6f4h3cck 927 72 of of IN cord-267475-6f4h3cck 927 73 restricted restricted JJ cord-267475-6f4h3cck 927 74 cell cell NN cord-267475-6f4h3cck 927 75 tropism tropism NN cord-267475-6f4h3cck 927 76 of of IN cord-267475-6f4h3cck 927 77 erythrovirus erythrovirus NNP cord-267475-6f4h3cck 927 78 B19 B19 NNP cord-267475-6f4h3cck 927 79 Initiation Initiation NNP cord-267475-6f4h3cck 927 80 codon codon NN cord-267475-6f4h3cck 927 81 scanthrough scanthrough NN cord-267475-6f4h3cck 927 82 versus versus IN cord-267475-6f4h3cck 927 83 termination termination NN cord-267475-6f4h3cck 927 84 codon codon NN cord-267475-6f4h3cck 927 85 readthrough readthrough NN cord-267475-6f4h3cck 927 86 demonstrates demonstrate VBZ cord-267475-6f4h3cck 927 87 strong strong JJ cord-267475-6f4h3cck 927 88 potential potential NN cord-267475-6f4h3cck 927 89 for for IN cord-267475-6f4h3cck 927 90 major major JJ cord-267475-6f4h3cck 927 91 histocompatibility histocompatibility NN cord-267475-6f4h3cck 927 92 complex complex JJ cord-267475-6f4h3cck 927 93 class class NN cord-267475-6f4h3cck 927 94 I i NN cord-267475-6f4h3cck 927 95 - - HYPH cord-267475-6f4h3cck 927 96 restricted restrict VBN cord-267475-6f4h3cck 927 97 cryptic cryptic JJ cord-267475-6f4h3cck 927 98 epitope epitope NN cord-267475-6f4h3cck 927 99 expression expression NN cord-267475-6f4h3cck 927 100 Generation generation NN cord-267475-6f4h3cck 927 101 of of IN cord-267475-6f4h3cck 927 102 multiple multiple JJ cord-267475-6f4h3cck 927 103 isoforms isoform NNS cord-267475-6f4h3cck 927 104 of of IN cord-267475-6f4h3cck 927 105 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 927 106 translation translation NN cord-267475-6f4h3cck 927 107 initiation initiation NN cord-267475-6f4h3cck 927 108 factor factor NN cord-267475-6f4h3cck 927 109 4GI 4GI NNS cord-267475-6f4h3cck 927 110 by by IN cord-267475-6f4h3cck 927 111 use use NN cord-267475-6f4h3cck 927 112 of of IN cord-267475-6f4h3cck 927 113 alternate alternate JJ cord-267475-6f4h3cck 927 114 translation translation NN cord-267475-6f4h3cck 927 115 initiation initiation NN cord-267475-6f4h3cck 927 116 codons codon NNS cord-267475-6f4h3cck 927 117 Translational translational JJ cord-267475-6f4h3cck 927 118 control control NN cord-267475-6f4h3cck 927 119 of of IN cord-267475-6f4h3cck 927 120 mammalian mammalian JJ cord-267475-6f4h3cck 927 121 serine serine NN cord-267475-6f4h3cck 927 122 hydroxymethyl hydroxymethyl NN cord-267475-6f4h3cck 927 123 - - HYPH cord-267475-6f4h3cck 927 124 transferase transferase NN cord-267475-6f4h3cck 927 125 expression expression NN cord-267475-6f4h3cck 927 126 Targeted target VBN cord-267475-6f4h3cck 927 127 mutagenesis mutagenesis NN cord-267475-6f4h3cck 927 128 of of IN cord-267475-6f4h3cck 927 129 Lis1 Lis1 NNP cord-267475-6f4h3cck 927 130 disrupts disrupt VBZ cord-267475-6f4h3cck 927 131 cortical cortical JJ cord-267475-6f4h3cck 927 132 development development NN cord-267475-6f4h3cck 927 133 and and CC cord-267475-6f4h3cck 927 134 LIS1 LIS1 NNP cord-267475-6f4h3cck 927 135 homodimerization homodimerization NNP cord-267475-6f4h3cck 928 1 Two two CD cord-267475-6f4h3cck 928 2 novel novel NN cord-267475-6f4h3cck 928 3 b b NN cord-267475-6f4h3cck 928 4 - - HYPH cord-267475-6f4h3cck 928 5 thalassemia thalassemia NN cord-267475-6f4h3cck 928 6 mutations mutation NNS cord-267475-6f4h3cck 928 7 in in IN cord-267475-6f4h3cck 928 8 the the DT cord-267475-6f4h3cck 928 9 5 5 CD cord-267475-6f4h3cck 928 10 0 0 CD cord-267475-6f4h3cck 928 11 and and CC cord-267475-6f4h3cck 928 12 3 3 CD cord-267475-6f4h3cck 928 13 0 0 CD cord-267475-6f4h3cck 928 14 noncoding noncoding JJ cord-267475-6f4h3cck 928 15 regions region NNS cord-267475-6f4h3cck 928 16 of of IN cord-267475-6f4h3cck 928 17 the the DT cord-267475-6f4h3cck 928 18 b b NN cord-267475-6f4h3cck 928 19 - - HYPH cord-267475-6f4h3cck 928 20 globin globin NN cord-267475-6f4h3cck 928 21 gene gene NN cord-267475-6f4h3cck 928 22 Translational translational JJ cord-267475-6f4h3cck 928 23 control control NN cord-267475-6f4h3cck 928 24 of of IN cord-267475-6f4h3cck 928 25 C/ C/ NNP cord-267475-6f4h3cck 928 26 EBPa EBPa NNS cord-267475-6f4h3cck 928 27 and and CC cord-267475-6f4h3cck 928 28 C C NNP cord-267475-6f4h3cck 928 29 / / SYM cord-267475-6f4h3cck 928 30 EBPb EBPb NNP cord-267475-6f4h3cck 928 31 isoform isoform NN cord-267475-6f4h3cck 928 32 expression expression NN cord-267475-6f4h3cck 928 33 Alternative alternative JJ cord-267475-6f4h3cck 928 34 translation translation NN cord-267475-6f4h3cck 928 35 initiation initiation NN cord-267475-6f4h3cck 928 36 site site NN cord-267475-6f4h3cck 928 37 usage usage NN cord-267475-6f4h3cck 928 38 results result NNS cord-267475-6f4h3cck 928 39 in in IN cord-267475-6f4h3cck 928 40 two two CD cord-267475-6f4h3cck 928 41 functionally functionally RB cord-267475-6f4h3cck 928 42 distinct distinct JJ cord-267475-6f4h3cck 928 43 forms form NNS cord-267475-6f4h3cck 928 44 of of IN cord-267475-6f4h3cck 928 45 the the DT cord-267475-6f4h3cck 928 46 GATA-1 GATA-1 NNP cord-267475-6f4h3cck 928 47 transcription transcription NN cord-267475-6f4h3cck 928 48 factor factor NN cord-267475-6f4h3cck 928 49 Structure Structure NNP cord-267475-6f4h3cck 928 50 of of IN cord-267475-6f4h3cck 928 51 the the DT cord-267475-6f4h3cck 928 52 PCCA PCCA NNP cord-267475-6f4h3cck 928 53 gene gene NN cord-267475-6f4h3cck 928 54 and and CC cord-267475-6f4h3cck 928 55 distribution distribution NN cord-267475-6f4h3cck 928 56 of of IN cord-267475-6f4h3cck 928 57 mutations mutation NNS cord-267475-6f4h3cck 928 58 causing cause VBG cord-267475-6f4h3cck 928 59 propionic propionic JJ cord-267475-6f4h3cck 928 60 acidemia acidemia NN cord-267475-6f4h3cck 928 61 Translational translational JJ cord-267475-6f4h3cck 928 62 inhibition inhibition NN cord-267475-6f4h3cck 928 63 by by IN cord-267475-6f4h3cck 928 64 a a DT cord-267475-6f4h3cck 928 65 human human JJ cord-267475-6f4h3cck 928 66 cytomegalovirus cytomegalovirus NN cord-267475-6f4h3cck 928 67 upstream upstream IN cord-267475-6f4h3cck 928 68 open open JJ cord-267475-6f4h3cck 928 69 reading reading NN cord-267475-6f4h3cck 928 70 frame frame NN cord-267475-6f4h3cck 928 71 despite despite IN cord-267475-6f4h3cck 928 72 inefficient inefficient JJ cord-267475-6f4h3cck 928 73 utilization utilization NN cord-267475-6f4h3cck 928 74 of of IN cord-267475-6f4h3cck 928 75 its -PRON- PRP$ cord-267475-6f4h3cck 928 76 AUG AUG NNP cord-267475-6f4h3cck 928 77 codon codon NN cord-267475-6f4h3cck 929 1 The the DT cord-267475-6f4h3cck 929 2 secreted secrete VBN cord-267475-6f4h3cck 929 3 form form NN cord-267475-6f4h3cck 929 4 of of IN cord-267475-6f4h3cck 929 5 invertase invertase NN cord-267475-6f4h3cck 929 6 in in IN cord-267475-6f4h3cck 929 7 Saccharomyces Saccharomyces NNP cord-267475-6f4h3cck 929 8 cerevisiae cerevisiae NNS cord-267475-6f4h3cck 929 9 is be VBZ cord-267475-6f4h3cck 929 10 synthesized synthesize VBN cord-267475-6f4h3cck 929 11 from from IN cord-267475-6f4h3cck 929 12 mRNA mrna NN cord-267475-6f4h3cck 929 13 encoding encode VBG cord-267475-6f4h3cck 929 14 a a DT cord-267475-6f4h3cck 929 15 signal signal JJ cord-267475-6f4h3cck 929 16 sequence sequence NN cord-267475-6f4h3cck 929 17 Translation translation NN cord-267475-6f4h3cck 929 18 of of IN cord-267475-6f4h3cck 929 19 equine equine JJ cord-267475-6f4h3cck 929 20 infectious infectious JJ cord-267475-6f4h3cck 929 21 anemia anemia NN cord-267475-6f4h3cck 929 22 virus virus NN cord-267475-6f4h3cck 930 1 bicistronic bicistronic NNP cord-267475-6f4h3cck 930 2 tat tat NNP cord-267475-6f4h3cck 930 3 - - HYPH cord-267475-6f4h3cck 930 4 rev rev NNP cord-267475-6f4h3cck 930 5 mRNA mRNA NNP cord-267475-6f4h3cck 930 6 requires require VBZ cord-267475-6f4h3cck 930 7 leaky leaky JJ cord-267475-6f4h3cck 930 8 ribosome ribosome NN cord-267475-6f4h3cck 930 9 scanning scanning NN cord-267475-6f4h3cck 930 10 of of IN cord-267475-6f4h3cck 930 11 the the DT cord-267475-6f4h3cck 930 12 tat tat NNP cord-267475-6f4h3cck 930 13 CTG CTG NNP cord-267475-6f4h3cck 930 14 initiation initiation NN cord-267475-6f4h3cck 930 15 codon codon NN cord-267475-6f4h3cck 930 16 Transcription transcription NN cord-267475-6f4h3cck 930 17 of of IN cord-267475-6f4h3cck 930 18 feline feline JJ cord-267475-6f4h3cck 930 19 calicivirus calicivirus NNP cord-267475-6f4h3cck 930 20 RNA RNA NNP cord-267475-6f4h3cck 930 21 Translational Translational NNP cord-267475-6f4h3cck 930 22 pathophysiology pathophysiology NN cord-267475-6f4h3cck 930 23 : : : cord-267475-6f4h3cck 930 24 a a DT cord-267475-6f4h3cck 930 25 novel novel JJ cord-267475-6f4h3cck 930 26 molecular molecular JJ cord-267475-6f4h3cck 930 27 mechanism mechanism NN cord-267475-6f4h3cck 930 28 of of IN cord-267475-6f4h3cck 930 29 human human JJ cord-267475-6f4h3cck 930 30 disease disease NN cord-267475-6f4h3cck 930 31 A a DT cord-267475-6f4h3cck 930 32 novel novel JJ cord-267475-6f4h3cck 930 33 deletion deletion NN cord-267475-6f4h3cck 930 34 of of IN cord-267475-6f4h3cck 930 35 the the DT cord-267475-6f4h3cck 930 36 L l NN cord-267475-6f4h3cck 930 37 - - HYPH cord-267475-6f4h3cck 930 38 ferritin ferritin VBG cord-267475-6f4h3cck 930 39 iron iron NN cord-267475-6f4h3cck 930 40 - - HYPH cord-267475-6f4h3cck 930 41 responsive responsive JJ cord-267475-6f4h3cck 930 42 element element NN cord-267475-6f4h3cck 930 43 responsible responsible JJ cord-267475-6f4h3cck 930 44 for for IN cord-267475-6f4h3cck 930 45 severe severe JJ cord-267475-6f4h3cck 930 46 hereditary hereditary JJ cord-267475-6f4h3cck 930 47 hyperferritinaemia hyperferritinaemia NN cord-267475-6f4h3cck 930 48 - - HYPH cord-267475-6f4h3cck 930 49 cataract cataract NN cord-267475-6f4h3cck 930 50 syndrome syndrome NN cord-267475-6f4h3cck 930 51 Phenotype phenotype NN cord-267475-6f4h3cck 930 52 - - HYPH cord-267475-6f4h3cck 930 53 genotype genotype NN cord-267475-6f4h3cck 930 54 relationships relationship NNS cord-267475-6f4h3cck 930 55 in in IN cord-267475-6f4h3cck 930 56 complementation complementation NN cord-267475-6f4h3cck 930 57 group group NN cord-267475-6f4h3cck 930 58 3 3 CD cord-267475-6f4h3cck 930 59 of of IN cord-267475-6f4h3cck 930 60 the the DT cord-267475-6f4h3cck 930 61 peroxisome peroxisome NN cord-267475-6f4h3cck 930 62 - - HYPH cord-267475-6f4h3cck 930 63 biogenesis biogenesis NN cord-267475-6f4h3cck 930 64 disorders disorder NNS cord-267475-6f4h3cck 931 1 The the DT cord-267475-6f4h3cck 931 2 increased increased JJ cord-267475-6f4h3cck 931 3 level level NN cord-267475-6f4h3cck 931 4 of of IN cord-267475-6f4h3cck 931 5 b1,4-galactosyltransferase b1,4-galactosyltransferase NNP cord-267475-6f4h3cck 931 6 required require VBN cord-267475-6f4h3cck 931 7 for for IN cord-267475-6f4h3cck 931 8 lactose lactose JJ cord-267475-6f4h3cck 931 9 biosynthesis biosynthesis NN cord-267475-6f4h3cck 931 10 is be VBZ cord-267475-6f4h3cck 931 11 achieved achieve VBN cord-267475-6f4h3cck 931 12 in in IN cord-267475-6f4h3cck 931 13 part part NN cord-267475-6f4h3cck 931 14 by by IN cord-267475-6f4h3cck 931 15 translational translational JJ cord-267475-6f4h3cck 931 16 control control NN cord-267475-6f4h3cck 932 1 The the DT cord-267475-6f4h3cck 932 2 yeast yeast NN cord-267475-6f4h3cck 932 3 VAS1 VAS1 NNP cord-267475-6f4h3cck 932 4 gene gene NN cord-267475-6f4h3cck 932 5 encodes encode VBZ cord-267475-6f4h3cck 932 6 both both DT cord-267475-6f4h3cck 932 7 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 932 8 and and CC cord-267475-6f4h3cck 932 9 cytoplasmic cytoplasmic JJ cord-267475-6f4h3cck 932 10 valyl valyl JJ cord-267475-6f4h3cck 932 11 - - HYPH cord-267475-6f4h3cck 932 12 tRNA trna NN cord-267475-6f4h3cck 932 13 synthetases synthetases NNP cord-267475-6f4h3cck 932 14 Structure Structure NNP cord-267475-6f4h3cck 932 15 of of IN cord-267475-6f4h3cck 932 16 the the DT cord-267475-6f4h3cck 932 17 GM2A GM2A NNP cord-267475-6f4h3cck 932 18 gene gene NN cord-267475-6f4h3cck 932 19 : : : cord-267475-6f4h3cck 932 20 identification identification NN cord-267475-6f4h3cck 932 21 of of IN cord-267475-6f4h3cck 932 22 an an DT cord-267475-6f4h3cck 932 23 exon exon JJ cord-267475-6f4h3cck 932 24 2 2 CD cord-267475-6f4h3cck 932 25 nonsense nonsense NN cord-267475-6f4h3cck 932 26 mutation mutation NN cord-267475-6f4h3cck 932 27 and and CC cord-267475-6f4h3cck 932 28 a a DT cord-267475-6f4h3cck 932 29 naturally naturally RB cord-267475-6f4h3cck 932 30 occurring occur VBG cord-267475-6f4h3cck 932 31 transcript transcript NN cord-267475-6f4h3cck 932 32 with with IN cord-267475-6f4h3cck 932 33 an an DT cord-267475-6f4h3cck 932 34 in in IN cord-267475-6f4h3cck 932 35 - - HYPH cord-267475-6f4h3cck 932 36 frame frame NN cord-267475-6f4h3cck 932 37 deletion deletion NN cord-267475-6f4h3cck 932 38 of of IN cord-267475-6f4h3cck 932 39 exon exon NN cord-267475-6f4h3cck 932 40 2 2 CD cord-267475-6f4h3cck 932 41 Initiation initiation NN cord-267475-6f4h3cck 932 42 of of IN cord-267475-6f4h3cck 932 43 protein protein NN cord-267475-6f4h3cck 932 44 synthesis synthesis NN cord-267475-6f4h3cck 932 45 by by IN cord-267475-6f4h3cck 932 46 the the DT cord-267475-6f4h3cck 932 47 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 932 48 translational translational JJ cord-267475-6f4h3cck 932 49 apparatus apparatus NN cord-267475-6f4h3cck 932 50 on on IN cord-267475-6f4h3cck 932 51 circular circular JJ cord-267475-6f4h3cck 932 52 RNAs rna NNS cord-267475-6f4h3cck 933 1 A a DT cord-267475-6f4h3cck 933 2 novel novel JJ cord-267475-6f4h3cck 933 3 influenza influenza NN cord-267475-6f4h3cck 933 4 A a DT cord-267475-6f4h3cck 933 5 virus virus NN cord-267475-6f4h3cck 933 6 mitochondrial mitochondrial NN cord-267475-6f4h3cck 933 7 protein protein NN cord-267475-6f4h3cck 933 8 that that WDT cord-267475-6f4h3cck 933 9 induces induce VBZ cord-267475-6f4h3cck 933 10 cell cell NN cord-267475-6f4h3cck 933 11 death death NN cord-267475-6f4h3cck 933 12 Translation translation NN cord-267475-6f4h3cck 933 13 initiation initiation NN cord-267475-6f4h3cck 933 14 at at IN cord-267475-6f4h3cck 933 15 alternate alternate JJ cord-267475-6f4h3cck 933 16 in in IN cord-267475-6f4h3cck 933 17 - - HYPH cord-267475-6f4h3cck 933 18 frame frame NN cord-267475-6f4h3cck 933 19 AUG AUG NNP cord-267475-6f4h3cck 933 20 codons codon NNS cord-267475-6f4h3cck 933 21 in in IN cord-267475-6f4h3cck 933 22 the the DT cord-267475-6f4h3cck 933 23 rabies rabies NN cord-267475-6f4h3cck 933 24 virus virus NN cord-267475-6f4h3cck 934 1 phosphoprotein phosphoprotein NNP cord-267475-6f4h3cck 934 2 mRNA mRNA NNP cord-267475-6f4h3cck 934 3 is be VBZ cord-267475-6f4h3cck 934 4 mediated mediate VBN cord-267475-6f4h3cck 934 5 by by IN cord-267475-6f4h3cck 934 6 a a DT cord-267475-6f4h3cck 934 7 ribosomal ribosomal JJ cord-267475-6f4h3cck 934 8 leaky leaky JJ cord-267475-6f4h3cck 934 9 scanning scanning NN cord-267475-6f4h3cck 934 10 mechanism mechanism NN cord-267475-6f4h3cck 934 11 Translational translational JJ cord-267475-6f4h3cck 934 12 control control NN cord-267475-6f4h3cck 934 13 by by IN cord-267475-6f4h3cck 934 14 an an DT cord-267475-6f4h3cck 934 15 upstream upstream JJ cord-267475-6f4h3cck 934 16 open open JJ cord-267475-6f4h3cck 934 17 reading reading NN cord-267475-6f4h3cck 934 18 frame frame NN cord-267475-6f4h3cck 934 19 in in IN cord-267475-6f4h3cck 934 20 the the DT cord-267475-6f4h3cck 934 21 HER-2 HER-2 NNP cord-267475-6f4h3cck 934 22 / / SYM cord-267475-6f4h3cck 934 23 neu neu NNP cord-267475-6f4h3cck 934 24 transcript transcript NN cord-267475-6f4h3cck 934 25 Cell Cell NNP cord-267475-6f4h3cck 934 26 type type NN cord-267475-6f4h3cck 934 27 - - HYPH cord-267475-6f4h3cck 934 28 dependent dependent JJ cord-267475-6f4h3cck 934 29 andindependent andindependent JJ cord-267475-6f4h3cck 934 30 control control NN cord-267475-6f4h3cck 934 31 of of IN cord-267475-6f4h3cck 934 32 HER-2 HER-2 NNP cord-267475-6f4h3cck 934 33 / / SYM cord-267475-6f4h3cck 934 34 neu neu NNP cord-267475-6f4h3cck 934 35 translation translation NN cord-267475-6f4h3cck 935 1 A a DT cord-267475-6f4h3cck 935 2 novel novel JJ cord-267475-6f4h3cck 935 3 missense missense NN cord-267475-6f4h3cck 935 4 mutation mutation NN cord-267475-6f4h3cck 935 5 in in IN cord-267475-6f4h3cck 935 6 the the DT cord-267475-6f4h3cck 935 7 amino amino NN cord-267475-6f4h3cck 935 8 - - HYPH cord-267475-6f4h3cck 935 9 terminal terminal NN cord-267475-6f4h3cck 935 10 domain domain NN cord-267475-6f4h3cck 935 11 of of IN cord-267475-6f4h3cck 935 12 the the DT cord-267475-6f4h3cck 935 13 human human JJ cord-267475-6f4h3cck 935 14 androgen androgen NN cord-267475-6f4h3cck 935 15 receptor receptor NN cord-267475-6f4h3cck 935 16 gene gene NN cord-267475-6f4h3cck 935 17 in in IN cord-267475-6f4h3cck 935 18 a a DT cord-267475-6f4h3cck 935 19 family family NN cord-267475-6f4h3cck 935 20 with with IN cord-267475-6f4h3cck 935 21 partial partial JJ cord-267475-6f4h3cck 935 22 androgen androgen NN cord-267475-6f4h3cck 935 23 insensitivity insensitivity NN cord-267475-6f4h3cck 935 24 syndrome syndrome NN cord-267475-6f4h3cck 935 25 causes cause VBZ cord-267475-6f4h3cck 935 26 reduced reduce VBN cord-267475-6f4h3cck 935 27 efficiency efficiency NN cord-267475-6f4h3cck 935 28 of of IN cord-267475-6f4h3cck 935 29 protein protein NN cord-267475-6f4h3cck 935 30 translation translation NN cord-267475-6f4h3cck 936 1 Two two CD cord-267475-6f4h3cck 936 2 distinct distinct JJ cord-267475-6f4h3cck 936 3 protein protein NN cord-267475-6f4h3cck 936 4 isoforms isoform NNS cord-267475-6f4h3cck 936 5 are be VBP cord-267475-6f4h3cck 936 6 encoded encode VBN cord-267475-6f4h3cck 936 7 by by IN cord-267475-6f4h3cck 936 8 ntk ntk NNP cord-267475-6f4h3cck 936 9 , , , cord-267475-6f4h3cck 936 10 a a DT cord-267475-6f4h3cck 936 11 csk csk NNP cord-267475-6f4h3cck 936 12 - - HYPH cord-267475-6f4h3cck 936 13 related relate VBN cord-267475-6f4h3cck 936 14 tyrosine tyrosine NN cord-267475-6f4h3cck 936 15 protein protein NN cord-267475-6f4h3cck 936 16 kinase kinase NN cord-267475-6f4h3cck 936 17 gene gene NN cord-267475-6f4h3cck 936 18 Alternative alternative JJ cord-267475-6f4h3cck 936 19 transcription transcription NN cord-267475-6f4h3cck 936 20 and and CC cord-267475-6f4h3cck 936 21 splicing splicing NN cord-267475-6f4h3cck 936 22 of of IN cord-267475-6f4h3cck 936 23 the the DT cord-267475-6f4h3cck 936 24 human human JJ cord-267475-6f4h3cck 936 25 porphobilinogen porphobilinogen NNP cord-267475-6f4h3cck 936 26 deaminase deaminase NNP cord-267475-6f4h3cck 936 27 gene gene NN cord-267475-6f4h3cck 936 28 result result NN cord-267475-6f4h3cck 936 29 either either CC cord-267475-6f4h3cck 936 30 in in IN cord-267475-6f4h3cck 936 31 tissue tissue NN cord-267475-6f4h3cck 936 32 - - HYPH cord-267475-6f4h3cck 936 33 specific specific JJ cord-267475-6f4h3cck 936 34 or or CC cord-267475-6f4h3cck 936 35 in in IN cord-267475-6f4h3cck 936 36 housekeeping housekeeping NN cord-267475-6f4h3cck 936 37 expression expression NN cord-267475-6f4h3cck 936 38 tRNA tRNA NNP cord-267475-6f4h3cck 936 39 met meet VBD cord-267475-6f4h3cck 936 40 functions function NNS cord-267475-6f4h3cck 936 41 in in IN cord-267475-6f4h3cck 936 42 directing direct VBG cord-267475-6f4h3cck 936 43 the the DT cord-267475-6f4h3cck 936 44 scanning scanning NN cord-267475-6f4h3cck 936 45 ribosome ribosome NN cord-267475-6f4h3cck 936 46 to to IN cord-267475-6f4h3cck 936 47 the the DT cord-267475-6f4h3cck 936 48 start start NN cord-267475-6f4h3cck 936 49 site site NN cord-267475-6f4h3cck 936 50 of of IN cord-267475-6f4h3cck 936 51 translation translation NN cord-267475-6f4h3cck 936 52 Mutational Mutational NNP cord-267475-6f4h3cck 936 53 analysis analysis NN cord-267475-6f4h3cck 936 54 of of IN cord-267475-6f4h3cck 936 55 the the DT cord-267475-6f4h3cck 936 56 HIS4 HIS4 NNP cord-267475-6f4h3cck 936 57 translational translational JJ cord-267475-6f4h3cck 936 58 initiator initiator NN cord-267475-6f4h3cck 936 59 region region NN cord-267475-6f4h3cck 936 60 in in IN cord-267475-6f4h3cck 936 61 Saccharomyces Saccharomyces NNP cord-267475-6f4h3cck 936 62 cerevisiae cerevisiae VBZ cord-267475-6f4h3cck 936 63 Initiation initiation NN cord-267475-6f4h3cck 936 64 factor factor NN cord-267475-6f4h3cck 936 65 eIF2a eif2a JJ cord-267475-6f4h3cck 936 66 phosphorylation phosphorylation NN cord-267475-6f4h3cck 936 67 in in IN cord-267475-6f4h3cck 936 68 stress stress NN cord-267475-6f4h3cck 936 69 responses response NNS cord-267475-6f4h3cck 936 70 and and CC cord-267475-6f4h3cck 936 71 apoptosis apoptosis NN cord-267475-6f4h3cck 936 72 Tissue tissue NN cord-267475-6f4h3cck 936 73 - - HYPH cord-267475-6f4h3cck 936 74 and and CC cord-267475-6f4h3cck 936 75 development development NN cord-267475-6f4h3cck 936 76 - - HYPH cord-267475-6f4h3cck 936 77 specific specific JJ cord-267475-6f4h3cck 936 78 alternative alternative JJ cord-267475-6f4h3cck 936 79 RNA RNA NNP cord-267475-6f4h3cck 936 80 splicing splicing NN cord-267475-6f4h3cck 936 81 regulates regulate VBZ cord-267475-6f4h3cck 936 82 expression expression NN cord-267475-6f4h3cck 936 83 of of IN cord-267475-6f4h3cck 936 84 multiple multiple JJ cord-267475-6f4h3cck 936 85 isoforms isoform NNS cord-267475-6f4h3cck 936 86 of of IN cord-267475-6f4h3cck 936 87 erythroid erythroid NN cord-267475-6f4h3cck 936 88 membrane membrane NN cord-267475-6f4h3cck 936 89 protein protein NN cord-267475-6f4h3cck 936 90 4.1 4.1 CD cord-267475-6f4h3cck 936 91 Identification identification NN cord-267475-6f4h3cck 936 92 of of IN cord-267475-6f4h3cck 936 93 the the DT cord-267475-6f4h3cck 936 94 serum serum NN cord-267475-6f4h3cck 936 95 - - HYPH cord-267475-6f4h3cck 936 96 responsive responsive JJ cord-267475-6f4h3cck 936 97 transcription transcription NN cord-267475-6f4h3cck 936 98 initiation initiation NN cord-267475-6f4h3cck 936 99 site site NN cord-267475-6f4h3cck 936 100 of of IN cord-267475-6f4h3cck 936 101 the the DT cord-267475-6f4h3cck 936 102 zinc zinc NN cord-267475-6f4h3cck 936 103 finger finger NN cord-267475-6f4h3cck 936 104 gene gene NN cord-267475-6f4h3cck 936 105 Krox-20 Krox-20 NNP cord-267475-6f4h3cck 937 1 Fibroblast fibroblast JJ cord-267475-6f4h3cck 937 2 growth growth NN cord-267475-6f4h3cck 937 3 factor factor NN cord-267475-6f4h3cck 937 4 2 2 CD cord-267475-6f4h3cck 937 5 internal internal JJ cord-267475-6f4h3cck 937 6 ribosome ribosome NN cord-267475-6f4h3cck 937 7 entry entry NN cord-267475-6f4h3cck 937 8 site site NN cord-267475-6f4h3cck 937 9 ( ( -LRB- cord-267475-6f4h3cck 937 10 IRES IRES NNP cord-267475-6f4h3cck 937 11 ) ) -RRB- cord-267475-6f4h3cck 937 12 activity activity NN cord-267475-6f4h3cck 938 1 ex ex NNP cord-267475-6f4h3cck 938 2 vivo vivo NNP cord-267475-6f4h3cck 938 3 and and CC cord-267475-6f4h3cck 938 4 in in IN cord-267475-6f4h3cck 938 5 transgenic transgenic JJ cord-267475-6f4h3cck 938 6 mice mouse NNS cord-267475-6f4h3cck 938 7 reveals reveal VBZ cord-267475-6f4h3cck 938 8 a a DT cord-267475-6f4h3cck 938 9 stringent stringent JJ cord-267475-6f4h3cck 938 10 tissue tissue NN cord-267475-6f4h3cck 938 11 - - HYPH cord-267475-6f4h3cck 938 12 specific specific JJ cord-267475-6f4h3cck 938 13 regulation regulation NN cord-267475-6f4h3cck 938 14 c c NN cord-267475-6f4h3cck 938 15 - - HYPH cord-267475-6f4h3cck 938 16 myc myc NNP cord-267475-6f4h3cck 938 17 internal internal JJ cord-267475-6f4h3cck 938 18 ribosome ribosome NN cord-267475-6f4h3cck 938 19 entry entry NN cord-267475-6f4h3cck 938 20 site site NN cord-267475-6f4h3cck 938 21 activity activity NN cord-267475-6f4h3cck 938 22 is be VBZ cord-267475-6f4h3cck 938 23 developmentally developmentally RB cord-267475-6f4h3cck 938 24 controlled control VBN cord-267475-6f4h3cck 938 25 and and CC cord-267475-6f4h3cck 938 26 subjected subject VBN cord-267475-6f4h3cck 938 27 to to IN cord-267475-6f4h3cck 938 28 a a DT cord-267475-6f4h3cck 938 29 strong strong JJ cord-267475-6f4h3cck 938 30 translational translational JJ cord-267475-6f4h3cck 938 31 repression repression NN cord-267475-6f4h3cck 938 32 in in IN cord-267475-6f4h3cck 938 33 adult adult NN cord-267475-6f4h3cck 938 34 transgenic transgenic JJ cord-267475-6f4h3cck 938 35 mice mouse NNS cord-267475-6f4h3cck 939 1 The the DT cord-267475-6f4h3cck 939 2 Arabidopsis Arabidopsis NNP cord-267475-6f4h3cck 939 3 thaliana thaliana NN cord-267475-6f4h3cck 939 4 FPS1 FPS1 NNP cord-267475-6f4h3cck 939 5 gene gene NN cord-267475-6f4h3cck 939 6 generates generate VBZ cord-267475-6f4h3cck 939 7 a a DT cord-267475-6f4h3cck 939 8 novel novel NN cord-267475-6f4h3cck 939 9 mRNA mrna NN cord-267475-6f4h3cck 939 10 that that WDT cord-267475-6f4h3cck 939 11 encodes encode VBZ cord-267475-6f4h3cck 939 12 a a DT cord-267475-6f4h3cck 939 13 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 939 14 farnesyldiphosphate farnesyldiphosphate NN cord-267475-6f4h3cck 939 15 synthase synthase NN cord-267475-6f4h3cck 939 16 isoform isoform NN cord-267475-6f4h3cck 939 17 Alternatively alternatively RB cord-267475-6f4h3cck 939 18 spliced splice VBD cord-267475-6f4h3cck 939 19 human human JJ cord-267475-6f4h3cck 939 20 type type NN cord-267475-6f4h3cck 939 21 1 1 CD cord-267475-6f4h3cck 939 22 angiotensin angiotensin NN cord-267475-6f4h3cck 939 23 II ii CD cord-267475-6f4h3cck 939 24 receptor receptor NN cord-267475-6f4h3cck 939 25 mRNAs mrnas WDT cord-267475-6f4h3cck 939 26 are be VBP cord-267475-6f4h3cck 939 27 translated translate VBN cord-267475-6f4h3cck 939 28 at at IN cord-267475-6f4h3cck 939 29 different different JJ cord-267475-6f4h3cck 939 30 efficiencies efficiency NNS cord-267475-6f4h3cck 939 31 and and CC cord-267475-6f4h3cck 939 32 encode encode VB cord-267475-6f4h3cck 939 33 two two CD cord-267475-6f4h3cck 939 34 receptor receptor NN cord-267475-6f4h3cck 939 35 isoforms isoform NNS cord-267475-6f4h3cck 939 36 Eukaryotic eukaryotic JJ cord-267475-6f4h3cck 939 37 translation translation NN cord-267475-6f4h3cck 939 38 initiation initiation NN cord-267475-6f4h3cck 939 39 factor factor NN cord-267475-6f4h3cck 939 40 5 5 CD cord-267475-6f4h3cck 939 41 functions function NNS cord-267475-6f4h3cck 939 42 as as IN cord-267475-6f4h3cck 939 43 a a DT cord-267475-6f4h3cck 939 44 GTPase GTPase NNP cord-267475-6f4h3cck 939 45 - - HYPH cord-267475-6f4h3cck 939 46 activating activate VBG cord-267475-6f4h3cck 939 47 protein protein NN cord-267475-6f4h3cck 940 1 The the DT cord-267475-6f4h3cck 940 2 S4 S4 NNP cord-267475-6f4h3cck 940 3 genome genome NN cord-267475-6f4h3cck 940 4 segment segment NN cord-267475-6f4h3cck 940 5 of of IN cord-267475-6f4h3cck 940 6 baboon baboon NN cord-267475-6f4h3cck 940 7 reovirus reovirus NNP cord-267475-6f4h3cck 940 8 is be VBZ cord-267475-6f4h3cck 940 9 bicistronic bicistronic JJ cord-267475-6f4h3cck 940 10 and and CC cord-267475-6f4h3cck 940 11 encodes encode VBZ cord-267475-6f4h3cck 940 12 a a DT cord-267475-6f4h3cck 940 13 novel novel JJ cord-267475-6f4h3cck 940 14 fusion fusion NN cord-267475-6f4h3cck 940 15 - - HYPH cord-267475-6f4h3cck 940 16 associated associate VBN cord-267475-6f4h3cck 940 17 small small JJ cord-267475-6f4h3cck 940 18 transmembrane transmembrane NN cord-267475-6f4h3cck 940 19 protein protein NN cord-267475-6f4h3cck 940 20 Expression expression NN cord-267475-6f4h3cck 940 21 and and CC cord-267475-6f4h3cck 940 22 function function NN cord-267475-6f4h3cck 940 23 of of IN cord-267475-6f4h3cck 940 24 CCAAT CCAAT NNP cord-267475-6f4h3cck 940 25 / / SYM cord-267475-6f4h3cck 940 26 enhancer enhancer NN cord-267475-6f4h3cck 940 27 binding bind VBG cord-267475-6f4h3cck 940 28 protein protein NN cord-267475-6f4h3cck 940 29 b b LS cord-267475-6f4h3cck 940 30 ( ( -LRB- cord-267475-6f4h3cck 940 31 C/ C/ NNP cord-267475-6f4h3cck 940 32 EBPb EBPb NNS cord-267475-6f4h3cck 940 33 ) ) -RRB- cord-267475-6f4h3cck 940 34 LAP lap NN cord-267475-6f4h3cck 940 35 and and CC cord-267475-6f4h3cck 940 36 LIP lip NN cord-267475-6f4h3cck 940 37 isoforms isoform NNS cord-267475-6f4h3cck 940 38 in in IN cord-267475-6f4h3cck 940 39 mouse mouse NN cord-267475-6f4h3cck 940 40 mammary mammary JJ cord-267475-6f4h3cck 940 41 gland gland NN cord-267475-6f4h3cck 940 42 , , , cord-267475-6f4h3cck 940 43 tumors tumor NNS cord-267475-6f4h3cck 940 44 and and CC cord-267475-6f4h3cck 940 45 cultured cultured JJ cord-267475-6f4h3cck 940 46 mammary mammary JJ cord-267475-6f4h3cck 940 47 epithelial epithelial JJ cord-267475-6f4h3cck 940 48 cells cell NNS cord-267475-6f4h3cck 941 1 rlk/ rlk/ NNP cord-267475-6f4h3cck 942 1 TXK TXK NNP cord-267475-6f4h3cck 942 2 encodes encode VBZ cord-267475-6f4h3cck 942 3 two two CD cord-267475-6f4h3cck 942 4 forms form NNS cord-267475-6f4h3cck 942 5 of of IN cord-267475-6f4h3cck 942 6 a a DT cord-267475-6f4h3cck 942 7 novel novel JJ cord-267475-6f4h3cck 942 8 cysteine cysteine NN cord-267475-6f4h3cck 942 9 string string NN cord-267475-6f4h3cck 942 10 tyrosine tyrosine NN cord-267475-6f4h3cck 942 11 kinase kinase NN cord-267475-6f4h3cck 942 12 activated activate VBN cord-267475-6f4h3cck 942 13 by by IN cord-267475-6f4h3cck 942 14 Src Src NNP cord-267475-6f4h3cck 942 15 family family NN cord-267475-6f4h3cck 942 16 kinases kinase VBZ cord-267475-6f4h3cck 942 17 Characterization characterization NN cord-267475-6f4h3cck 942 18 of of IN cord-267475-6f4h3cck 942 19 an an DT cord-267475-6f4h3cck 942 20 internal internal JJ cord-267475-6f4h3cck 942 21 ribosomal ribosomal NN cord-267475-6f4h3cck 942 22 entry entry NN cord-267475-6f4h3cck 942 23 segment segment NN cord-267475-6f4h3cck 942 24 in in IN cord-267475-6f4h3cck 942 25 the the DT cord-267475-6f4h3cck 942 26 5 5 CD cord-267475-6f4h3cck 942 27 0 0 CD cord-267475-6f4h3cck 942 28 leader leader NN cord-267475-6f4h3cck 942 29 of of IN cord-267475-6f4h3cck 942 30 murine murine JJ cord-267475-6f4h3cck 942 31 leukemia leukemia NN cord-267475-6f4h3cck 942 32 virus virus NN cord-267475-6f4h3cck 942 33 env env NNP cord-267475-6f4h3cck 942 34 RNA RNA NNP cord-267475-6f4h3cck 942 35 A A NNP cord-267475-6f4h3cck 942 36 novel novel JJ cord-267475-6f4h3cck 942 37 subgenomic subgenomic NNP cord-267475-6f4h3cck 942 38 murine murine NNP cord-267475-6f4h3cck 942 39 leukemia leukemia NNP cord-267475-6f4h3cck 942 40 virus virus NN cord-267475-6f4h3cck 942 41 RNA RNA NNP cord-267475-6f4h3cck 942 42 transcript transcript NN cord-267475-6f4h3cck 942 43 results result VBZ cord-267475-6f4h3cck 942 44 from from IN cord-267475-6f4h3cck 942 45 alternative alternative JJ cord-267475-6f4h3cck 942 46 splicing splicing NN cord-267475-6f4h3cck 942 47 EIF2AK3 eif2ak3 NN cord-267475-6f4h3cck 942 48 , , , cord-267475-6f4h3cck 942 49 encoding encode VBG cord-267475-6f4h3cck 942 50 translation translation NN cord-267475-6f4h3cck 942 51 initiation initiation NN cord-267475-6f4h3cck 942 52 factor factor NN cord-267475-6f4h3cck 942 53 2-a 2-a CD cord-267475-6f4h3cck 942 54 kinase kinase NN cord-267475-6f4h3cck 942 55 3 3 CD cord-267475-6f4h3cck 942 56 , , , cord-267475-6f4h3cck 942 57 is be VBZ cord-267475-6f4h3cck 942 58 mutated mutate VBN cord-267475-6f4h3cck 942 59 in in IN cord-267475-6f4h3cck 942 60 patients patient NNS cord-267475-6f4h3cck 942 61 with with IN cord-267475-6f4h3cck 942 62 Wolcott Wolcott NNP cord-267475-6f4h3cck 942 63 - - HYPH cord-267475-6f4h3cck 942 64 Rallison Rallison NNP cord-267475-6f4h3cck 942 65 syndrome syndrome NN cord-267475-6f4h3cck 942 66 Transcriptional Transcriptional NNP cord-267475-6f4h3cck 942 67 regulation regulation NN cord-267475-6f4h3cck 942 68 of of IN cord-267475-6f4h3cck 942 69 the the DT cord-267475-6f4h3cck 942 70 interleukin-6 interleukin-6 NNP cord-267475-6f4h3cck 942 71 gene gene NN cord-267475-6f4h3cck 942 72 of of IN cord-267475-6f4h3cck 942 73 human human JJ cord-267475-6f4h3cck 942 74 herpesvirus herpesvirus NNP cord-267475-6f4h3cck 942 75 8 8 CD cord-267475-6f4h3cck 942 76 ( ( -LRB- cord-267475-6f4h3cck 942 77 Kaposi Kaposi NNP cord-267475-6f4h3cck 942 78 's 's POS cord-267475-6f4h3cck 942 79 sarcomaassociated sarcomaassociate VBN cord-267475-6f4h3cck 942 80 herpesvirus herpesvirus NNP cord-267475-6f4h3cck 942 81 ) ) -RRB- cord-267475-6f4h3cck 942 82 ERa era NN cord-267475-6f4h3cck 942 83 gene gene NN cord-267475-6f4h3cck 942 84 expression expression NN cord-267475-6f4h3cck 942 85 in in IN cord-267475-6f4h3cck 942 86 human human JJ cord-267475-6f4h3cck 942 87 primary primary JJ cord-267475-6f4h3cck 942 88 osteoblasts osteoblast NNS cord-267475-6f4h3cck 942 89 : : : cord-267475-6f4h3cck 943 1 evidence evidence NN cord-267475-6f4h3cck 943 2 for for IN cord-267475-6f4h3cck 943 3 the the DT cord-267475-6f4h3cck 943 4 expression expression NN cord-267475-6f4h3cck 943 5 of of IN cord-267475-6f4h3cck 943 6 two two CD cord-267475-6f4h3cck 943 7 receptor receptor NN cord-267475-6f4h3cck 943 8 proteins protein NNS cord-267475-6f4h3cck 944 1 A a DT cord-267475-6f4h3cck 944 2 liver liver NN cord-267475-6f4h3cck 944 3 - - HYPH cord-267475-6f4h3cck 944 4 enriched enrich VBN cord-267475-6f4h3cck 944 5 transcriptional transcriptional JJ cord-267475-6f4h3cck 944 6 activator activator NN cord-267475-6f4h3cck 944 7 protein protein NN cord-267475-6f4h3cck 944 8 , , , cord-267475-6f4h3cck 944 9 LAP LAP NNP cord-267475-6f4h3cck 944 10 , , , cord-267475-6f4h3cck 944 11 and and CC cord-267475-6f4h3cck 944 12 a a DT cord-267475-6f4h3cck 944 13 transcriptional transcriptional JJ cord-267475-6f4h3cck 944 14 inhibitory inhibitory JJ cord-267475-6f4h3cck 944 15 protein protein NN cord-267475-6f4h3cck 944 16 , , , cord-267475-6f4h3cck 944 17 LIP lip NN cord-267475-6f4h3cck 944 18 , , , cord-267475-6f4h3cck 944 19 are be VBP cord-267475-6f4h3cck 944 20 translated translate VBN cord-267475-6f4h3cck 944 21 from from IN cord-267475-6f4h3cck 944 22 the the DT cord-267475-6f4h3cck 944 23 same same JJ cord-267475-6f4h3cck 944 24 mRNA mRNA NNP cord-267475-6f4h3cck 944 25 Gene gene NN cord-267475-6f4h3cck 944 26 - - HYPH cord-267475-6f4h3cck 944 27 specific specific JJ cord-267475-6f4h3cck 944 28 regulation regulation NN cord-267475-6f4h3cck 944 29 by by IN cord-267475-6f4h3cck 944 30 general general JJ cord-267475-6f4h3cck 944 31 translation translation NN cord-267475-6f4h3cck 944 32 factors factor NNS cord-267475-6f4h3cck 945 1 Genomic genomic JJ cord-267475-6f4h3cck 945 2 structure structure NN cord-267475-6f4h3cck 945 3 of of IN cord-267475-6f4h3cck 945 4 Unp Unp NNP cord-267475-6f4h3cck 945 5 , , , cord-267475-6f4h3cck 945 6 a a DT cord-267475-6f4h3cck 945 7 murine murine JJ cord-267475-6f4h3cck 945 8 gene gene NN cord-267475-6f4h3cck 945 9 encoding encode VBG cord-267475-6f4h3cck 945 10 a a DT cord-267475-6f4h3cck 945 11 ubiquitin ubiquitin NN cord-267475-6f4h3cck 945 12 - - HYPH cord-267475-6f4h3cck 945 13 specific specific JJ cord-267475-6f4h3cck 945 14 protease protease NN cord-267475-6f4h3cck 945 15 Control Control NNP cord-267475-6f4h3cck 945 16 of of IN cord-267475-6f4h3cck 945 17 start start NN cord-267475-6f4h3cck 945 18 codon codon NN cord-267475-6f4h3cck 945 19 choice choice NN cord-267475-6f4h3cck 945 20 on on IN cord-267475-6f4h3cck 945 21 a a DT cord-267475-6f4h3cck 945 22 plant plant NN cord-267475-6f4h3cck 945 23 viral viral JJ cord-267475-6f4h3cck 945 24 RNA rna NN cord-267475-6f4h3cck 945 25 encoding encode VBG cord-267475-6f4h3cck 945 26 overlapping overlap VBG cord-267475-6f4h3cck 945 27 genes gene NNS cord-267475-6f4h3cck 945 28 The the DT cord-267475-6f4h3cck 945 29 first first JJ cord-267475-6f4h3cck 945 30 and and CC cord-267475-6f4h3cck 945 31 third third JJ cord-267475-6f4h3cck 945 32 uORFs uorfs CD cord-267475-6f4h3cck 945 33 in in IN cord-267475-6f4h3cck 945 34 RSV RSV NNP cord-267475-6f4h3cck 945 35 leader leader NN cord-267475-6f4h3cck 945 36 RNA RNA NNP cord-267475-6f4h3cck 945 37 are be VBP cord-267475-6f4h3cck 945 38 efficiently efficiently RB cord-267475-6f4h3cck 945 39 translated translate VBN cord-267475-6f4h3cck 945 40 : : : cord-267475-6f4h3cck 945 41 implications implication NNS cord-267475-6f4h3cck 945 42 for for IN cord-267475-6f4h3cck 945 43 translational translational JJ cord-267475-6f4h3cck 945 44 regulation regulation NN cord-267475-6f4h3cck 945 45 and and CC cord-267475-6f4h3cck 945 46 viral viral JJ cord-267475-6f4h3cck 945 47 RNA RNA NNP cord-267475-6f4h3cck 945 48 packaging packaging NN cord-267475-6f4h3cck 945 49 Identification identification NN cord-267475-6f4h3cck 945 50 of of IN cord-267475-6f4h3cck 945 51 eight eight CD cord-267475-6f4h3cck 945 52 novel novel JJ cord-267475-6f4h3cck 945 53 5 5 CD cord-267475-6f4h3cck 945 54 0 0 CD cord-267475-6f4h3cck 945 55 -exons -exon NNS cord-267475-6f4h3cck 945 56 in in IN cord-267475-6f4h3cck 945 57 cerebral cerebral JJ cord-267475-6f4h3cck 945 58 capillary capillary JJ cord-267475-6f4h3cck 945 59 malformation malformation NN cord-267475-6f4h3cck 945 60 gene-1 gene-1 NNP cord-267475-6f4h3cck 946 1 ( ( -LRB- cord-267475-6f4h3cck 946 2 CCM1 CCM1 NNP cord-267475-6f4h3cck 946 3 ) ) -RRB- cord-267475-6f4h3cck 946 4 encoding encoding NN cord-267475-6f4h3cck 947 1 KRIT1 krit1 VB cord-267475-6f4h3cck 948 1 Picornavirus Picornavirus NNP cord-267475-6f4h3cck 948 2 internal internal JJ cord-267475-6f4h3cck 948 3 ribosome ribosome NN cord-267475-6f4h3cck 948 4 entry entry NN cord-267475-6f4h3cck 948 5 site site NN cord-267475-6f4h3cck 948 6 elements element NNS cord-267475-6f4h3cck 948 7 target target VBP cord-267475-6f4h3cck 948 8 RNA RNA NNP cord-267475-6f4h3cck 948 9 cleavage cleavage NN cord-267475-6f4h3cck 948 10 events event NNS cord-267475-6f4h3cck 948 11 induced induce VBN cord-267475-6f4h3cck 948 12 by by IN cord-267475-6f4h3cck 948 13 the the DT cord-267475-6f4h3cck 948 14 herpes herpes NNP cord-267475-6f4h3cck 948 15 simplex simplex NNP cord-267475-6f4h3cck 948 16 virus virus NN cord-267475-6f4h3cck 948 17 virion virion NN cord-267475-6f4h3cck 948 18 host host NN cord-267475-6f4h3cck 948 19 - - HYPH cord-267475-6f4h3cck 948 20 shutoff shutoff NN cord-267475-6f4h3cck 948 21 protein protein NN cord-267475-6f4h3cck 948 22 Nucleotide nucleotide JJ cord-267475-6f4h3cck 948 23 sequence sequence NN cord-267475-6f4h3cck 948 24 and and CC cord-267475-6f4h3cck 948 25 expression expression NN cord-267475-6f4h3cck 948 26 of of IN cord-267475-6f4h3cck 948 27 the the DT cord-267475-6f4h3cck 948 28 small small JJ cord-267475-6f4h3cck 948 29 ( ( -LRB- cord-267475-6f4h3cck 948 30 S S NNP cord-267475-6f4h3cck 948 31 ) ) -RRB- cord-267475-6f4h3cck 948 32 RNA rna NN cord-267475-6f4h3cck 948 33 segment segment NN cord-267475-6f4h3cck 948 34 of of IN cord-267475-6f4h3cck 948 35 Maguari Maguari NNP cord-267475-6f4h3cck 948 36 bunyavirus bunyavirus NN cord-267475-6f4h3cck 948 37 Amino amino NN cord-267475-6f4h3cck 948 38 - - HYPH cord-267475-6f4h3cck 948 39 terminal terminal NN cord-267475-6f4h3cck 948 40 extension extension NN cord-267475-6f4h3cck 948 41 generated generate VBN cord-267475-6f4h3cck 948 42 from from IN cord-267475-6f4h3cck 948 43 an an DT cord-267475-6f4h3cck 948 44 upstream upstream JJ cord-267475-6f4h3cck 948 45 AUG AUG NNP cord-267475-6f4h3cck 948 46 codon codon NN cord-267475-6f4h3cck 948 47 increases increase VBZ cord-267475-6f4h3cck 948 48 the the DT cord-267475-6f4h3cck 948 49 efficiency efficiency NN cord-267475-6f4h3cck 948 50 of of IN cord-267475-6f4h3cck 948 51 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 948 52 import import NN cord-267475-6f4h3cck 948 53 of of IN cord-267475-6f4h3cck 948 54 yeast yeast NN cord-267475-6f4h3cck 948 55 N n CD cord-267475-6f4h3cck 948 56 2 2 CD cord-267475-6f4h3cck 948 57 , , , cord-267475-6f4h3cck 948 58 N n CD cord-267475-6f4h3cck 948 59 2 2 CD cord-267475-6f4h3cck 948 60 -dimethylguanosine -dimethylguanosine CD cord-267475-6f4h3cck 948 61 - - HYPH cord-267475-6f4h3cck 948 62 specific specific JJ cord-267475-6f4h3cck 948 63 tRNA trna NN cord-267475-6f4h3cck 948 64 methyltransferases methyltransferase NNS cord-267475-6f4h3cck 948 65 Gastric gastric JJ cord-267475-6f4h3cck 948 66 cancers cancer NNS cord-267475-6f4h3cck 948 67 overexpress overexpress VBP cord-267475-6f4h3cck 948 68 DARPP-32 darpp-32 CD cord-267475-6f4h3cck 948 69 and and CC cord-267475-6f4h3cck 948 70 a a DT cord-267475-6f4h3cck 948 71 novel novel JJ cord-267475-6f4h3cck 948 72 isoform isoform NN cord-267475-6f4h3cck 948 73 , , , cord-267475-6f4h3cck 948 74 t t NN cord-267475-6f4h3cck 948 75 - - HYPH cord-267475-6f4h3cck 948 76 DARPP DARPP NNP cord-267475-6f4h3cck 949 1 A a DT cord-267475-6f4h3cck 949 2 common common JJ cord-267475-6f4h3cck 949 3 C c NN cord-267475-6f4h3cck 949 4 ! ! . cord-267475-6f4h3cck 950 1 T T NNP cord-267475-6f4h3cck 950 2 polymorphism polymorphism NN cord-267475-6f4h3cck 950 3 at at IN cord-267475-6f4h3cck 950 4 nt nt RB cord-267475-6f4h3cck 950 5 46 46 CD cord-267475-6f4h3cck 950 6 in in IN cord-267475-6f4h3cck 950 7 the the DT cord-267475-6f4h3cck 950 8 promoter promoter NN cord-267475-6f4h3cck 950 9 region region NN cord-267475-6f4h3cck 950 10 of of IN cord-267475-6f4h3cck 950 11 coagulation coagulation NN cord-267475-6f4h3cck 950 12 factor factor NN cord-267475-6f4h3cck 951 1 XII XII NNP cord-267475-6f4h3cck 951 2 is be VBZ cord-267475-6f4h3cck 951 3 associated associate VBN cord-267475-6f4h3cck 951 4 with with IN cord-267475-6f4h3cck 951 5 decreased decreased JJ cord-267475-6f4h3cck 951 6 factor factor NN cord-267475-6f4h3cck 951 7 XII xii NN cord-267475-6f4h3cck 951 8 activity activity NN cord-267475-6f4h3cck 951 9 Translation translation NN cord-267475-6f4h3cck 951 10 of of IN cord-267475-6f4h3cck 951 11 bicistronic bicistronic JJ cord-267475-6f4h3cck 951 12 viral viral JJ cord-267475-6f4h3cck 951 13 mRNA mrna NN cord-267475-6f4h3cck 951 14 in in IN cord-267475-6f4h3cck 951 15 transfected transfecte VBN cord-267475-6f4h3cck 951 16 cells cell NNS cord-267475-6f4h3cck 951 17 : : : cord-267475-6f4h3cck 951 18 regulation regulation NN cord-267475-6f4h3cck 951 19 at at IN cord-267475-6f4h3cck 951 20 the the DT cord-267475-6f4h3cck 951 21 level level NN cord-267475-6f4h3cck 951 22 of of IN cord-267475-6f4h3cck 951 23 elongation elongation NN cord-267475-6f4h3cck 951 24 A a DT cord-267475-6f4h3cck 951 25 31-amino 31-amino CD cord-267475-6f4h3cck 951 26 acid acid NN cord-267475-6f4h3cck 951 27 N n CD cord-267475-6f4h3cck 951 28 - - HYPH cord-267475-6f4h3cck 951 29 terminal terminal NN cord-267475-6f4h3cck 951 30 extension extension NN cord-267475-6f4h3cck 951 31 regulates regulate VBZ cord-267475-6f4h3cck 951 32 c c NNP cord-267475-6f4h3cck 951 33 - - HYPH cord-267475-6f4h3cck 951 34 Crk Crk NNP cord-267475-6f4h3cck 951 35 binding bind VBG cord-267475-6f4h3cck 951 36 to to IN cord-267475-6f4h3cck 951 37 tyrosine tyrosine NN cord-267475-6f4h3cck 951 38 - - HYPH cord-267475-6f4h3cck 951 39 phosphorylated phosphorylate VBN cord-267475-6f4h3cck 951 40 proteins protein NNS cord-267475-6f4h3cck 952 1 The the DT cord-267475-6f4h3cck 952 2 rat rat NN cord-267475-6f4h3cck 952 3 hepatic hepatic JJ cord-267475-6f4h3cck 952 4 leukemia leukemia NN cord-267475-6f4h3cck 952 5 factor factor NN cord-267475-6f4h3cck 952 6 ( ( -LRB- cord-267475-6f4h3cck 952 7 HLF HLF NNP cord-267475-6f4h3cck 952 8 ) ) -RRB- cord-267475-6f4h3cck 952 9 gene gene NN cord-267475-6f4h3cck 952 10 encodes encode VBZ cord-267475-6f4h3cck 952 11 two two CD cord-267475-6f4h3cck 952 12 transcriptional transcriptional JJ cord-267475-6f4h3cck 952 13 activators activator NNS cord-267475-6f4h3cck 952 14 with with IN cord-267475-6f4h3cck 952 15 distinct distinct JJ cord-267475-6f4h3cck 952 16 circadian circadian NN cord-267475-6f4h3cck 952 17 rhythms rhythm NNS cord-267475-6f4h3cck 952 18 , , , cord-267475-6f4h3cck 952 19 tissue tissue NN cord-267475-6f4h3cck 952 20 distributions distribution NNS cord-267475-6f4h3cck 952 21 and and CC cord-267475-6f4h3cck 952 22 target target NN cord-267475-6f4h3cck 952 23 preferences preference NNS cord-267475-6f4h3cck 953 1 Molecular molecular JJ cord-267475-6f4h3cck 953 2 characterization characterization NN cord-267475-6f4h3cck 953 3 of of IN cord-267475-6f4h3cck 953 4 Pax6 Pax6 NNP cord-267475-6f4h3cck 953 5 2Neu 2neu NN cord-267475-6f4h3cck 953 6 through through IN cord-267475-6f4h3cck 953 7 Pax6 Pax6 NNP cord-267475-6f4h3cck 953 8 10Neu 10Neu NNP cord-267475-6f4h3cck 953 9 : : : cord-267475-6f4h3cck 953 10 an an DT cord-267475-6f4h3cck 953 11 extension extension NN cord-267475-6f4h3cck 953 12 of of IN cord-267475-6f4h3cck 953 13 the the DT cord-267475-6f4h3cck 953 14 Pax6 Pax6 NNP cord-267475-6f4h3cck 953 15 allelic allelic JJ cord-267475-6f4h3cck 953 16 series series NN cord-267475-6f4h3cck 953 17 and and CC cord-267475-6f4h3cck 953 18 the the DT cord-267475-6f4h3cck 953 19 identification identification NN cord-267475-6f4h3cck 953 20 of of IN cord-267475-6f4h3cck 953 21 two two CD cord-267475-6f4h3cck 953 22 possible possible JJ cord-267475-6f4h3cck 953 23 hypomorph hypomorph NN cord-267475-6f4h3cck 953 24 alleles allele NNS cord-267475-6f4h3cck 953 25 in in IN cord-267475-6f4h3cck 953 26 the the DT cord-267475-6f4h3cck 953 27 mouse mouse NN cord-267475-6f4h3cck 953 28 Mus Mus NNP cord-267475-6f4h3cck 953 29 musculus musculus NN cord-267475-6f4h3cck 953 30 Human Human NNP cord-267475-6f4h3cck 953 31 basic basic JJ cord-267475-6f4h3cck 953 32 fibroblast fibroblast NN cord-267475-6f4h3cck 953 33 growth growth NN cord-267475-6f4h3cck 953 34 factor factor NN cord-267475-6f4h3cck 954 1 gene gene NNP cord-267475-6f4h3cck 954 2 encodes encode VBZ cord-267475-6f4h3cck 954 3 four four CD cord-267475-6f4h3cck 954 4 polypeptides polypeptide NNS cord-267475-6f4h3cck 954 5 : : : cord-267475-6f4h3cck 954 6 three three CD cord-267475-6f4h3cck 954 7 initiate initiate VB cord-267475-6f4h3cck 954 8 translation translation NN cord-267475-6f4h3cck 954 9 from from IN cord-267475-6f4h3cck 954 10 non non JJ cord-267475-6f4h3cck 954 11 - - JJ cord-267475-6f4h3cck 954 12 AUG AUG NNP cord-267475-6f4h3cck 954 13 codons codon NNS cord-267475-6f4h3cck 954 14 Identification Identification NNP cord-267475-6f4h3cck 954 15 of of IN cord-267475-6f4h3cck 954 16 a a DT cord-267475-6f4h3cck 954 17 new new JJ cord-267475-6f4h3cck 954 18 isoform isoform NN cord-267475-6f4h3cck 954 19 of of IN cord-267475-6f4h3cck 954 20 the the DT cord-267475-6f4h3cck 954 21 human human JJ cord-267475-6f4h3cck 954 22 estrogen estrogen NN cord-267475-6f4h3cck 954 23 receptor receptor NN cord-267475-6f4h3cck 954 24 - - HYPH cord-267475-6f4h3cck 954 25 alpha alpha NN cord-267475-6f4h3cck 954 26 ( ( -LRB- cord-267475-6f4h3cck 954 27 hER hER NNP cord-267475-6f4h3cck 954 28 - - HYPH cord-267475-6f4h3cck 954 29 a a LS cord-267475-6f4h3cck 954 30 ) ) -RRB- cord-267475-6f4h3cck 954 31 that that WDT cord-267475-6f4h3cck 954 32 is be VBZ cord-267475-6f4h3cck 954 33 encoded encode VBN cord-267475-6f4h3cck 954 34 by by IN cord-267475-6f4h3cck 954 35 distinct distinct JJ cord-267475-6f4h3cck 954 36 transcripts transcript NNS cord-267475-6f4h3cck 954 37 and and CC cord-267475-6f4h3cck 954 38 that that DT cord-267475-6f4h3cck 954 39 is be VBZ cord-267475-6f4h3cck 954 40 able able JJ cord-267475-6f4h3cck 954 41 to to TO cord-267475-6f4h3cck 954 42 repress repress VB cord-267475-6f4h3cck 954 43 hER her PRP cord-267475-6f4h3cck 954 44 - - : cord-267475-6f4h3cck 954 45 a a DT cord-267475-6f4h3cck 954 46 activation activation NN cord-267475-6f4h3cck 954 47 function function NN cord-267475-6f4h3cck 954 48 1 1 CD cord-267475-6f4h3cck 954 49 A a DT cord-267475-6f4h3cck 954 50 testisspecific testisspecific JJ cord-267475-6f4h3cck 954 51 promoter promoter NN cord-267475-6f4h3cck 954 52 in in IN cord-267475-6f4h3cck 954 53 the the DT cord-267475-6f4h3cck 954 54 rat rat NN cord-267475-6f4h3cck 954 55 vasopressin vasopressin NNP cord-267475-6f4h3cck 954 56 gene gene NN cord-267475-6f4h3cck 954 57 Translational Translational NNP cord-267475-6f4h3cck 954 58 stop stop NN cord-267475-6f4h3cck 954 59 codons codon NNS cord-267475-6f4h3cck 954 60 in in IN cord-267475-6f4h3cck 954 61 the the DT cord-267475-6f4h3cck 954 62 precore precore NN cord-267475-6f4h3cck 954 63 sequence sequence NN cord-267475-6f4h3cck 954 64 of of IN cord-267475-6f4h3cck 954 65 hepatitis hepatitis NN cord-267475-6f4h3cck 954 66 B B NNP cord-267475-6f4h3cck 954 67 virus virus NN cord-267475-6f4h3cck 954 68 pre pre NN cord-267475-6f4h3cck 954 69 - - NN cord-267475-6f4h3cck 954 70 C C NNP cord-267475-6f4h3cck 954 71 RNA RNA NNP cord-267475-6f4h3cck 955 1 allow allow VB cord-267475-6f4h3cck 955 2 translation translation NN cord-267475-6f4h3cck 955 3 reinitiation reinitiation NN cord-267475-6f4h3cck 955 4 at at IN cord-267475-6f4h3cck 955 5 downstream downstream JJ cord-267475-6f4h3cck 955 6 AUGs aug NNS cord-267475-6f4h3cck 955 7 Translation translation NN cord-267475-6f4h3cck 955 8 of of IN cord-267475-6f4h3cck 955 9 the the DT cord-267475-6f4h3cck 955 10 hepatitis hepatitis NN cord-267475-6f4h3cck 955 11 B B NNP cord-267475-6f4h3cck 955 12 virus virus NN cord-267475-6f4h3cck 955 13 P p NN cord-267475-6f4h3cck 955 14 gene gene NN cord-267475-6f4h3cck 955 15 by by IN cord-267475-6f4h3cck 955 16 ribosomal ribosomal JJ cord-267475-6f4h3cck 955 17 scanning scanning NN cord-267475-6f4h3cck 955 18 as as IN cord-267475-6f4h3cck 955 19 an an DT cord-267475-6f4h3cck 955 20 alternative alternative NN cord-267475-6f4h3cck 955 21 to to IN cord-267475-6f4h3cck 955 22 internal internal JJ cord-267475-6f4h3cck 955 23 initiation initiation NN cord-267475-6f4h3cck 955 24 Upstream Upstream NNP cord-267475-6f4h3cck 955 25 organization organization NN cord-267475-6f4h3cck 955 26 of of IN cord-267475-6f4h3cck 955 27 and and CC cord-267475-6f4h3cck 955 28 multiple multiple JJ cord-267475-6f4h3cck 955 29 transcripts transcript NNS cord-267475-6f4h3cck 955 30 from from IN cord-267475-6f4h3cck 955 31 the the DT cord-267475-6f4h3cck 955 32 human human JJ cord-267475-6f4h3cck 955 33 folylpoly folylpoly JJ cord-267475-6f4h3cck 955 34 - - HYPH cord-267475-6f4h3cck 955 35 gglutamate gglutamate JJ cord-267475-6f4h3cck 955 36 synthetase synthetase NN cord-267475-6f4h3cck 955 37 gene gene NN cord-267475-6f4h3cck 955 38 Nonsense nonsense NN cord-267475-6f4h3cck 955 39 - - HYPH cord-267475-6f4h3cck 955 40 mediated mediate VBN cord-267475-6f4h3cck 955 41 mRNA mrna NN cord-267475-6f4h3cck 955 42 decay decay NN cord-267475-6f4h3cck 955 43 in in IN cord-267475-6f4h3cck 955 44 health health NN cord-267475-6f4h3cck 955 45 and and CC cord-267475-6f4h3cck 955 46 disease disease NN cord-267475-6f4h3cck 956 1 HYAL1 HYAL1 NNP cord-267475-6f4h3cck 956 2 LUCA-1 LUCA-1 NNP cord-267475-6f4h3cck 956 3 , , , cord-267475-6f4h3cck 956 4 a a DT cord-267475-6f4h3cck 956 5 candidate candidate NN cord-267475-6f4h3cck 956 6 tumor tumor NN cord-267475-6f4h3cck 956 7 suppressor suppressor NN cord-267475-6f4h3cck 956 8 gene gene NN cord-267475-6f4h3cck 956 9 on on IN cord-267475-6f4h3cck 956 10 chromosome chromosome NN cord-267475-6f4h3cck 956 11 3p21.3 3p21.3 CD cord-267475-6f4h3cck 956 12 , , , cord-267475-6f4h3cck 956 13 is be VBZ cord-267475-6f4h3cck 956 14 inactivated inactivate VBN cord-267475-6f4h3cck 956 15 in in IN cord-267475-6f4h3cck 956 16 head head NN cord-267475-6f4h3cck 956 17 and and CC cord-267475-6f4h3cck 956 18 neck neck NN cord-267475-6f4h3cck 956 19 squamous squamous JJ cord-267475-6f4h3cck 956 20 cell cell NN cord-267475-6f4h3cck 956 21 carcinomas carcinoma NNS cord-267475-6f4h3cck 956 22 by by IN cord-267475-6f4h3cck 956 23 aberrant aberrant JJ cord-267475-6f4h3cck 956 24 splicing splicing NN cord-267475-6f4h3cck 956 25 of of IN cord-267475-6f4h3cck 956 26 pre pre JJ cord-267475-6f4h3cck 956 27 - - JJ cord-267475-6f4h3cck 956 28 mRNA mrna JJ cord-267475-6f4h3cck 956 29 Viral viral JJ cord-267475-6f4h3cck 956 30 and and CC cord-267475-6f4h3cck 956 31 cellular cellular JJ cord-267475-6f4h3cck 956 32 mRNA mrna NN cord-267475-6f4h3cck 956 33 capping capping NN cord-267475-6f4h3cck 956 34 : : : cord-267475-6f4h3cck 956 35 past past NN cord-267475-6f4h3cck 956 36 and and CC cord-267475-6f4h3cck 956 37 prospects prospect NNS cord-267475-6f4h3cck 956 38 Splicing splice VBG cord-267475-6f4h3cck 956 39 in in IN cord-267475-6f4h3cck 956 40 a a DT cord-267475-6f4h3cck 956 41 plant plant NN cord-267475-6f4h3cck 956 42 pararetrovirus pararetrovirus NNP cord-267475-6f4h3cck 956 43 Position position NN cord-267475-6f4h3cck 956 44 - - HYPH cord-267475-6f4h3cck 956 45 dependent dependent JJ cord-267475-6f4h3cck 956 46 ATT ATT NNP cord-267475-6f4h3cck 956 47 initiation initiation NN cord-267475-6f4h3cck 956 48 during during IN cord-267475-6f4h3cck 956 49 plant plant NN cord-267475-6f4h3cck 956 50 pararetrovirus pararetrovirus NNP cord-267475-6f4h3cck 956 51 rice rice NNP cord-267475-6f4h3cck 956 52 tungro tungro NNP cord-267475-6f4h3cck 957 1 bacilliform bacilliform NNP cord-267475-6f4h3cck 957 2 virus virus NNP cord-267475-6f4h3cck 957 3 translation translation NN cord-267475-6f4h3cck 958 1 Rice Rice NNP cord-267475-6f4h3cck 958 2 tungro tungro NNP cord-267475-6f4h3cck 958 3 bacilliform bacilliform NNP cord-267475-6f4h3cck 958 4 virus virus NN cord-267475-6f4h3cck 958 5 open open JJ cord-267475-6f4h3cck 958 6 reading reading NN cord-267475-6f4h3cck 958 7 frames frame NNS cord-267475-6f4h3cck 958 8 II II NNP cord-267475-6f4h3cck 958 9 and and CC cord-267475-6f4h3cck 958 10 III III NNP cord-267475-6f4h3cck 958 11 are be VBP cord-267475-6f4h3cck 958 12 translated translate VBN cord-267475-6f4h3cck 958 13 from from IN cord-267475-6f4h3cck 958 14 polycistronic polycistronic NNP cord-267475-6f4h3cck 958 15 pregenomic pregenomic NNP cord-267475-6f4h3cck 958 16 RNA RNA NNP cord-267475-6f4h3cck 958 17 by by IN cord-267475-6f4h3cck 958 18 leaky leaky JJ cord-267475-6f4h3cck 958 19 scanning scanning NN cord-267475-6f4h3cck 958 20 Translation translation NN cord-267475-6f4h3cck 958 21 of of IN cord-267475-6f4h3cck 958 22 p15.5 p15.5 NNP cord-267475-6f4h3cck 958 23 INK4B INK4B NNS cord-267475-6f4h3cck 958 24 , , , cord-267475-6f4h3cck 958 25 an an DT cord-267475-6f4h3cck 958 26 N n NN cord-267475-6f4h3cck 958 27 - - HYPH cord-267475-6f4h3cck 958 28 terminally terminally RB cord-267475-6f4h3cck 958 29 extended extended JJ cord-267475-6f4h3cck 958 30 and and CC cord-267475-6f4h3cck 958 31 fully fully RB cord-267475-6f4h3cck 958 32 active active JJ cord-267475-6f4h3cck 958 33 form form NN cord-267475-6f4h3cck 958 34 of of IN cord-267475-6f4h3cck 958 35 p15 p15 NN cord-267475-6f4h3cck 958 36 INK4B INK4B NNS cord-267475-6f4h3cck 958 37 , , , cord-267475-6f4h3cck 958 38 is be VBZ cord-267475-6f4h3cck 958 39 initiated initiate VBN cord-267475-6f4h3cck 958 40 from from IN cord-267475-6f4h3cck 958 41 an an DT cord-267475-6f4h3cck 958 42 upstream upstream JJ cord-267475-6f4h3cck 958 43 GUG GUG NNP cord-267475-6f4h3cck 958 44 codon codon NN cord-267475-6f4h3cck 958 45 Physical physical JJ cord-267475-6f4h3cck 958 46 evidence evidence NN cord-267475-6f4h3cck 958 47 for for IN cord-267475-6f4h3cck 958 48 distinct distinct JJ cord-267475-6f4h3cck 958 49 mechanisms mechanism NNS cord-267475-6f4h3cck 958 50 of of IN cord-267475-6f4h3cck 958 51 translational translational JJ cord-267475-6f4h3cck 958 52 control control NN cord-267475-6f4h3cck 958 53 by by IN cord-267475-6f4h3cck 958 54 upstream upstream JJ cord-267475-6f4h3cck 958 55 open open JJ cord-267475-6f4h3cck 958 56 reading reading NN cord-267475-6f4h3cck 958 57 frames frame NNS cord-267475-6f4h3cck 958 58 The the DT cord-267475-6f4h3cck 958 59 role role NN cord-267475-6f4h3cck 958 60 of of IN cord-267475-6f4h3cck 958 61 5 5 CD cord-267475-6f4h3cck 958 62 0 0 CD cord-267475-6f4h3cck 958 63 -leader -leader SYM cord-267475-6f4h3cck 958 64 length length NN cord-267475-6f4h3cck 958 65 , , , cord-267475-6f4h3cck 958 66 secondary secondary JJ cord-267475-6f4h3cck 958 67 structure structure NN cord-267475-6f4h3cck 958 68 and and CC cord-267475-6f4h3cck 958 69 PABP PABP NNP cord-267475-6f4h3cck 958 70 concentration concentration NN cord-267475-6f4h3cck 958 71 on on IN cord-267475-6f4h3cck 958 72 cap cap NN cord-267475-6f4h3cck 958 73 and and CC cord-267475-6f4h3cck 958 74 poly(A poly(a JJ cord-267475-6f4h3cck 958 75 ) ) -RRB- cord-267475-6f4h3cck 958 76 tail tail NN cord-267475-6f4h3cck 958 77 function function NN cord-267475-6f4h3cck 958 78 during during IN cord-267475-6f4h3cck 958 79 translation translation NN cord-267475-6f4h3cck 958 80 in in IN cord-267475-6f4h3cck 958 81 Xenopus Xenopus NNP cord-267475-6f4h3cck 958 82 oocytes oocyte NNS cord-267475-6f4h3cck 959 1 The the DT cord-267475-6f4h3cck 959 2 two two CD cord-267475-6f4h3cck 959 3 forms form NNS cord-267475-6f4h3cck 959 4 of of IN cord-267475-6f4h3cck 959 5 karyogamy karyogamy NN cord-267475-6f4h3cck 959 6 transcription transcription NN cord-267475-6f4h3cck 959 7 factor factor NN cord-267475-6f4h3cck 959 8 Kar4p Kar4p NNP cord-267475-6f4h3cck 959 9 are be VBP cord-267475-6f4h3cck 959 10 regulated regulate VBN cord-267475-6f4h3cck 959 11 by by IN cord-267475-6f4h3cck 959 12 differential differential JJ cord-267475-6f4h3cck 959 13 initiation initiation NN cord-267475-6f4h3cck 959 14 of of IN cord-267475-6f4h3cck 959 15 transcription transcription NN cord-267475-6f4h3cck 959 16 , , , cord-267475-6f4h3cck 959 17 translation translation NN cord-267475-6f4h3cck 959 18 , , , cord-267475-6f4h3cck 959 19 and and CC cord-267475-6f4h3cck 959 20 protein protein NN cord-267475-6f4h3cck 959 21 turnover turnover NN cord-267475-6f4h3cck 959 22 GCD10 GCD10 NNP cord-267475-6f4h3cck 959 23 , , , cord-267475-6f4h3cck 959 24 a a DT cord-267475-6f4h3cck 959 25 translational translational JJ cord-267475-6f4h3cck 959 26 repressor repressor NN cord-267475-6f4h3cck 959 27 of of IN cord-267475-6f4h3cck 959 28 GCN4 GCN4 NNP cord-267475-6f4h3cck 959 29 , , , cord-267475-6f4h3cck 959 30 is be VBZ cord-267475-6f4h3cck 959 31 the the DT cord-267475-6f4h3cck 959 32 RNA RNA NNP cord-267475-6f4h3cck 959 33 - - HYPH cord-267475-6f4h3cck 959 34 binding bind VBG cord-267475-6f4h3cck 959 35 subunit subunit NN cord-267475-6f4h3cck 959 36 of of IN cord-267475-6f4h3cck 959 37 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 959 38 translation translation NN cord-267475-6f4h3cck 959 39 initiation initiation NN cord-267475-6f4h3cck 959 40 factor-3 factor-3 NNP cord-267475-6f4h3cck 960 1 The the DT cord-267475-6f4h3cck 960 2 mRNA mRNA NNP cord-267475-6f4h3cck 960 3 structure structure NN cord-267475-6f4h3cck 960 4 has have VBZ cord-267475-6f4h3cck 960 5 potent potent JJ cord-267475-6f4h3cck 960 6 regulatory regulatory JJ cord-267475-6f4h3cck 960 7 effects effect NNS cord-267475-6f4h3cck 960 8 on on IN cord-267475-6f4h3cck 960 9 type type NN cord-267475-6f4h3cck 960 10 2 2 CD cord-267475-6f4h3cck 960 11 iodothyronine iodothyronine NNP cord-267475-6f4h3cck 960 12 deiodinase deiodinase NN cord-267475-6f4h3cck 960 13 expression expression NN cord-267475-6f4h3cck 961 1 A a DT cord-267475-6f4h3cck 961 2 single single JJ cord-267475-6f4h3cck 961 3 - - HYPH cord-267475-6f4h3cck 961 4 base base NN cord-267475-6f4h3cck 961 5 deletion deletion NN cord-267475-6f4h3cck 961 6 in in IN cord-267475-6f4h3cck 961 7 the the DT cord-267475-6f4h3cck 961 8 thrombopoietin thrombopoietin NNP cord-267475-6f4h3cck 961 9 ( ( -LRB- cord-267475-6f4h3cck 961 10 TPO TPO NNP cord-267475-6f4h3cck 961 11 ) ) -RRB- cord-267475-6f4h3cck 961 12 gene gene NN cord-267475-6f4h3cck 961 13 causes cause VBZ cord-267475-6f4h3cck 961 14 familial familial JJ cord-267475-6f4h3cck 961 15 essential essential JJ cord-267475-6f4h3cck 961 16 thrombocythemia thrombocythemia NN cord-267475-6f4h3cck 961 17 through through IN cord-267475-6f4h3cck 961 18 a a DT cord-267475-6f4h3cck 961 19 mechanism mechanism NN cord-267475-6f4h3cck 961 20 of of IN cord-267475-6f4h3cck 961 21 more more RBR cord-267475-6f4h3cck 961 22 efficient efficient JJ cord-267475-6f4h3cck 961 23 translation translation NN cord-267475-6f4h3cck 961 24 of of IN cord-267475-6f4h3cck 961 25 TPO TPO NNP cord-267475-6f4h3cck 961 26 mRNA mRNA NNP cord-267475-6f4h3cck 961 27 Thrombopoietin Thrombopoietin NNP cord-267475-6f4h3cck 961 28 production production NN cord-267475-6f4h3cck 961 29 is be VBZ cord-267475-6f4h3cck 961 30 inhibited inhibit VBN cord-267475-6f4h3cck 961 31 by by IN cord-267475-6f4h3cck 961 32 a a DT cord-267475-6f4h3cck 961 33 translational translational JJ cord-267475-6f4h3cck 961 34 mechanism mechanism NN cord-267475-6f4h3cck 961 35 Hereditary hereditary JJ cord-267475-6f4h3cck 961 36 thrombocythaemia thrombocythaemia NN cord-267475-6f4h3cck 961 37 in in IN cord-267475-6f4h3cck 961 38 a a DT cord-267475-6f4h3cck 961 39 Japanese japanese JJ cord-267475-6f4h3cck 961 40 family family NN cord-267475-6f4h3cck 961 41 is be VBZ cord-267475-6f4h3cck 961 42 caused cause VBN cord-267475-6f4h3cck 961 43 by by IN cord-267475-6f4h3cck 961 44 a a DT cord-267475-6f4h3cck 961 45 novel novel JJ cord-267475-6f4h3cck 961 46 point point NN cord-267475-6f4h3cck 961 47 mutation mutation NN cord-267475-6f4h3cck 961 48 in in IN cord-267475-6f4h3cck 961 49 the the DT cord-267475-6f4h3cck 961 50 thrombopoietin thrombopoietin NNP cord-267475-6f4h3cck 961 51 gene gene NN cord-267475-6f4h3cck 961 52 Initiation Initiation NNP cord-267475-6f4h3cck 961 53 of of IN cord-267475-6f4h3cck 961 54 translation translation NN cord-267475-6f4h3cck 961 55 directed direct VBN cord-267475-6f4h3cck 961 56 by by IN cord-267475-6f4h3cck 961 57 42S 42S NNP cord-267475-6f4h3cck 961 58 and and CC cord-267475-6f4h3cck 961 59 26S 26S NNP cord-267475-6f4h3cck 961 60 RNAs rna NNS cord-267475-6f4h3cck 961 61 from from IN cord-267475-6f4h3cck 961 62 Semliki Semliki NNP cord-267475-6f4h3cck 961 63 Forest Forest NNP cord-267475-6f4h3cck 961 64 virus virus NN cord-267475-6f4h3cck 961 65 in in IN cord-267475-6f4h3cck 961 66 vitro vitro FW cord-267475-6f4h3cck 961 67 A a DT cord-267475-6f4h3cck 961 68 common common JJ cord-267475-6f4h3cck 961 69 polymorphism polymorphism NN cord-267475-6f4h3cck 961 70 in in IN cord-267475-6f4h3cck 961 71 the the DT cord-267475-6f4h3cck 961 72 annexin annexin NN cord-267475-6f4h3cck 961 73 V V NNP cord-267475-6f4h3cck 961 74 Kozak Kozak NNP cord-267475-6f4h3cck 961 75 sequence sequence NN cord-267475-6f4h3cck 961 76 ( ( -LRB- cord-267475-6f4h3cck 961 77 21 21 CD cord-267475-6f4h3cck 961 78 C c NN cord-267475-6f4h3cck 961 79 . . . cord-267475-6f4h3cck 962 1 T T NNP cord-267475-6f4h3cck 962 2 ) ) -RRB- cord-267475-6f4h3cck 962 3 increases increase VBZ cord-267475-6f4h3cck 962 4 translation translation NN cord-267475-6f4h3cck 962 5 efficiency efficiency NN cord-267475-6f4h3cck 962 6 and and CC cord-267475-6f4h3cck 962 7 plasma plasma NN cord-267475-6f4h3cck 962 8 levels level NNS cord-267475-6f4h3cck 962 9 of of IN cord-267475-6f4h3cck 962 10 annexin annexin NNP cord-267475-6f4h3cck 962 11 V V NNP cord-267475-6f4h3cck 962 12 , , , cord-267475-6f4h3cck 962 13 and and CC cord-267475-6f4h3cck 962 14 decreases decrease VBZ cord-267475-6f4h3cck 962 15 the the DT cord-267475-6f4h3cck 962 16 risk risk NN cord-267475-6f4h3cck 962 17 of of IN cord-267475-6f4h3cck 962 18 myocardial myocardial JJ cord-267475-6f4h3cck 962 19 infarction infarction NN cord-267475-6f4h3cck 962 20 in in IN cord-267475-6f4h3cck 962 21 young young JJ cord-267475-6f4h3cck 962 22 patients patient NNS cord-267475-6f4h3cck 963 1 Position position NN cord-267475-6f4h3cck 963 2 is be VBZ cord-267475-6f4h3cck 963 3 the the DT cord-267475-6f4h3cck 963 4 critical critical JJ cord-267475-6f4h3cck 963 5 determinant determinant NN cord-267475-6f4h3cck 963 6 for for IN cord-267475-6f4h3cck 963 7 function function NN cord-267475-6f4h3cck 963 8 of of IN cord-267475-6f4h3cck 963 9 iron iron NN cord-267475-6f4h3cck 963 10 - - HYPH cord-267475-6f4h3cck 963 11 responsive responsive JJ cord-267475-6f4h3cck 963 12 elements element NNS cord-267475-6f4h3cck 963 13 as as IN cord-267475-6f4h3cck 964 1 translational translational JJ cord-267475-6f4h3cck 964 2 regulators regulator NNS cord-267475-6f4h3cck 964 3 Attenuated attenuate VBD cord-267475-6f4h3cck 964 4 APC APC NNP cord-267475-6f4h3cck 964 5 alleles allele NNS cord-267475-6f4h3cck 964 6 produce produce VBP cord-267475-6f4h3cck 964 7 functional functional JJ cord-267475-6f4h3cck 964 8 protein protein NN cord-267475-6f4h3cck 964 9 from from IN cord-267475-6f4h3cck 964 10 internal internal JJ cord-267475-6f4h3cck 964 11 translation translation NN cord-267475-6f4h3cck 964 12 initiation initiation NN cord-267475-6f4h3cck 964 13 Characterization characterization NN cord-267475-6f4h3cck 964 14 of of IN cord-267475-6f4h3cck 964 15 the the DT cord-267475-6f4h3cck 964 16 cis cis NNP cord-267475-6f4h3cck 964 17 - - HYPH cord-267475-6f4h3cck 964 18 acting act VBG cord-267475-6f4h3cck 964 19 elements element NNS cord-267475-6f4h3cck 964 20 controlling control VBG cord-267475-6f4h3cck 964 21 subgenomic subgenomic NNP cord-267475-6f4h3cck 964 22 mRNAs mRNAs NNPS cord-267475-6f4h3cck 964 23 of of IN cord-267475-6f4h3cck 964 24 Citrus Citrus NNP cord-267475-6f4h3cck 964 25 tristeza tristeza NNP cord-267475-6f4h3cck 964 26 virus virus NN cord-267475-6f4h3cck 964 27 : : : cord-267475-6f4h3cck 964 28 production production NN cord-267475-6f4h3cck 964 29 of of IN cord-267475-6f4h3cck 964 30 positive positive JJ cord-267475-6f4h3cck 964 31 - - HYPH cord-267475-6f4h3cck 964 32 and and CC cord-267475-6f4h3cck 964 33 negativestranded negativestranded JJ cord-267475-6f4h3cck 964 34 3 3 CD cord-267475-6f4h3cck 964 35 0 0 CD cord-267475-6f4h3cck 964 36 -terminal -terminal JJ cord-267475-6f4h3cck 964 37 and and CC cord-267475-6f4h3cck 964 38 positive positive JJ cord-267475-6f4h3cck 964 39 - - HYPH cord-267475-6f4h3cck 964 40 stranded strand VBN cord-267475-6f4h3cck 964 41 5 5 CD cord-267475-6f4h3cck 964 42 0 0 CD cord-267475-6f4h3cck 965 1 -terminal -terminal JJ cord-267475-6f4h3cck 965 2 RNAs RNAs NNPS cord-267475-6f4h3cck 965 3 Effect Effect NNP cord-267475-6f4h3cck 965 4 of of IN cord-267475-6f4h3cck 965 5 sequence sequence NN cord-267475-6f4h3cck 965 6 context context NN cord-267475-6f4h3cck 965 7 at at IN cord-267475-6f4h3cck 965 8 stop stop NN cord-267475-6f4h3cck 965 9 codons codon NNS cord-267475-6f4h3cck 965 10 on on IN cord-267475-6f4h3cck 965 11 efficiency efficiency NN cord-267475-6f4h3cck 965 12 of of IN cord-267475-6f4h3cck 965 13 reinitiation reinitiation NN cord-267475-6f4h3cck 965 14 in in IN cord-267475-6f4h3cck 965 15 GCN4 GCN4 NNP cord-267475-6f4h3cck 966 1 translational translational JJ cord-267475-6f4h3cck 966 2 control control NNP cord-267475-6f4h3cck 967 1 Diverse diverse JJ cord-267475-6f4h3cck 967 2 splicing splicing NN cord-267475-6f4h3cck 967 3 mechanisms mechanism NNS cord-267475-6f4h3cck 967 4 fuse fuse VBP cord-267475-6f4h3cck 967 5 the the DT cord-267475-6f4h3cck 967 6 evolutionarily evolutionarily RB cord-267475-6f4h3cck 967 7 conserved conserve VBN cord-267475-6f4h3cck 967 8 bicistronic bicistronic JJ cord-267475-6f4h3cck 967 9 MOCS1A MOCS1A NNP cord-267475-6f4h3cck 967 10 and and CC cord-267475-6f4h3cck 967 11 MOCS1B MOCS1B NNP cord-267475-6f4h3cck 967 12 open open JJ cord-267475-6f4h3cck 967 13 reading reading NN cord-267475-6f4h3cck 967 14 frames frame NNS cord-267475-6f4h3cck 968 1 An an DT cord-267475-6f4h3cck 968 2 imprinted imprinted JJ cord-267475-6f4h3cck 968 3 , , , cord-267475-6f4h3cck 968 4 mammalian mammalian JJ cord-267475-6f4h3cck 968 5 bicistronic bicistronic NNP cord-267475-6f4h3cck 968 6 transcript transcript NN cord-267475-6f4h3cck 968 7 encodes encode VBZ cord-267475-6f4h3cck 968 8 two two CD cord-267475-6f4h3cck 968 9 independent independent JJ cord-267475-6f4h3cck 968 10 proteins protein NNS cord-267475-6f4h3cck 968 11 Mapping mapping NN cord-267475-6f4h3cck 968 12 of of IN cord-267475-6f4h3cck 968 13 the the DT cord-267475-6f4h3cck 968 14 tobacco tobacco NN cord-267475-6f4h3cck 968 15 mosaic mosaic NNP cord-267475-6f4h3cck 968 16 virus virus NN cord-267475-6f4h3cck 968 17 movement movement NN cord-267475-6f4h3cck 968 18 protein protein NN cord-267475-6f4h3cck 968 19 and and CC cord-267475-6f4h3cck 968 20 coat coat NN cord-267475-6f4h3cck 968 21 protein protein NNP cord-267475-6f4h3cck 968 22 subgenomic subgenomic NNP cord-267475-6f4h3cck 968 23 RNA RNA NNP cord-267475-6f4h3cck 968 24 promoters promoter NNS cord-267475-6f4h3cck 968 25 A a DT cord-267475-6f4h3cck 968 26 link link NN cord-267475-6f4h3cck 968 27 between between IN cord-267475-6f4h3cck 968 28 diabetes diabetes NN cord-267475-6f4h3cck 968 29 and and CC cord-267475-6f4h3cck 968 30 atherosclerosis atherosclerosis NN cord-267475-6f4h3cck 968 31 : : : cord-267475-6f4h3cck 968 32 glucose glucose NN cord-267475-6f4h3cck 968 33 regulates regulate VBZ cord-267475-6f4h3cck 968 34 expression expression NN cord-267475-6f4h3cck 968 35 of of IN cord-267475-6f4h3cck 968 36 CD36 CD36 NNP cord-267475-6f4h3cck 968 37 at at IN cord-267475-6f4h3cck 968 38 the the DT cord-267475-6f4h3cck 968 39 level level NN cord-267475-6f4h3cck 968 40 of of IN cord-267475-6f4h3cck 968 41 translation translation NN cord-267475-6f4h3cck 969 1 The the DT cord-267475-6f4h3cck 969 2 vitamin vitamin NN cord-267475-6f4h3cck 969 3 D D NNP cord-267475-6f4h3cck 969 4 receptor receptor NN cord-267475-6f4h3cck 969 5 gene gene NN cord-267475-6f4h3cck 969 6 start start NN cord-267475-6f4h3cck 969 7 codon codon NN cord-267475-6f4h3cck 969 8 polymorphism polymorphism NN cord-267475-6f4h3cck 969 9 : : : cord-267475-6f4h3cck 969 10 a a DT cord-267475-6f4h3cck 969 11 functional functional JJ cord-267475-6f4h3cck 969 12 analysis analysis NN cord-267475-6f4h3cck 969 13 of of IN cord-267475-6f4h3cck 969 14 Fok Fok NNP cord-267475-6f4h3cck 970 1 I -PRON- PRP cord-267475-6f4h3cck 970 2 variants variant VBZ cord-267475-6f4h3cck 970 3 Cloning clone VBG cord-267475-6f4h3cck 970 4 and and CC cord-267475-6f4h3cck 970 5 expression expression NN cord-267475-6f4h3cck 970 6 of of IN cord-267475-6f4h3cck 970 7 two two CD cord-267475-6f4h3cck 970 8 human human JJ cord-267475-6f4h3cck 970 9 p70 p70 CD cord-267475-6f4h3cck 970 10 S6 S6 NNP cord-267475-6f4h3cck 970 11 kinase kinase NN cord-267475-6f4h3cck 970 12 polypeptides polypeptide NNS cord-267475-6f4h3cck 970 13 differing differ VBG cord-267475-6f4h3cck 970 14 only only RB cord-267475-6f4h3cck 970 15 at at IN cord-267475-6f4h3cck 970 16 their -PRON- PRP$ cord-267475-6f4h3cck 970 17 amino amino NN cord-267475-6f4h3cck 970 18 termini terminus NNS cord-267475-6f4h3cck 970 19 Mechanisms Mechanisms NNPS cord-267475-6f4h3cck 970 20 governing govern VBG cord-267475-6f4h3cck 970 21 expression expression NN cord-267475-6f4h3cck 970 22 of of IN cord-267475-6f4h3cck 970 23 the the DT cord-267475-6f4h3cck 970 24 v v NN cord-267475-6f4h3cck 970 25 - - HYPH cord-267475-6f4h3cck 970 26 FLIP flip NN cord-267475-6f4h3cck 970 27 gene gene NN cord-267475-6f4h3cck 970 28 of of IN cord-267475-6f4h3cck 970 29 Kaposi Kaposi NNP cord-267475-6f4h3cck 970 30 's 's POS cord-267475-6f4h3cck 970 31 sarcoma sarcoma NN cord-267475-6f4h3cck 970 32 - - HYPH cord-267475-6f4h3cck 970 33 associated associate VBN cord-267475-6f4h3cck 970 34 herpesvirus herpesvirus NN cord-267475-6f4h3cck 970 35 T t NN cord-267475-6f4h3cck 970 36 - - HYPH cord-267475-6f4h3cck 970 37 cell cell NN cord-267475-6f4h3cck 970 38 receptor receptor NN cord-267475-6f4h3cck 970 39 sequences sequence NNS cord-267475-6f4h3cck 970 40 that that WDT cord-267475-6f4h3cck 970 41 elicit elicit VBP cord-267475-6f4h3cck 970 42 strong strong JJ cord-267475-6f4h3cck 970 43 down down JJ cord-267475-6f4h3cck 970 44 - - HYPH cord-267475-6f4h3cck 970 45 regulation regulation NN cord-267475-6f4h3cck 970 46 of of IN cord-267475-6f4h3cck 970 47 premature premature JJ cord-267475-6f4h3cck 970 48 termination termination NN cord-267475-6f4h3cck 970 49 codon codon NN cord-267475-6f4h3cck 970 50 - - HYPH cord-267475-6f4h3cck 970 51 bearing bear VBG cord-267475-6f4h3cck 970 52 transcripts transcript NNS cord-267475-6f4h3cck 970 53 Mapping mapping NN cord-267475-6f4h3cck 970 54 and and CC cord-267475-6f4h3cck 970 55 expression expression NN cord-267475-6f4h3cck 970 56 of of IN cord-267475-6f4h3cck 970 57 southern southern JJ cord-267475-6f4h3cck 970 58 bean bean NN cord-267475-6f4h3cck 970 59 mosaic mosaic NNP cord-267475-6f4h3cck 970 60 virus virus NN cord-267475-6f4h3cck 970 61 genomic genomic JJ cord-267475-6f4h3cck 970 62 and and CC cord-267475-6f4h3cck 970 63 subgenomic subgenomic NNP cord-267475-6f4h3cck 970 64 RNAs RNAs NNPS cord-267475-6f4h3cck 970 65 Synthesis Synthesis NNP cord-267475-6f4h3cck 970 66 in in IN cord-267475-6f4h3cck 970 67 vitro vitro FW cord-267475-6f4h3cck 970 68 of of IN cord-267475-6f4h3cck 970 69 a a DT cord-267475-6f4h3cck 970 70 seven seven CD cord-267475-6f4h3cck 970 71 amino amino NN cord-267475-6f4h3cck 970 72 acid acid NN cord-267475-6f4h3cck 970 73 peptide peptide NN cord-267475-6f4h3cck 970 74 encoded encode VBN cord-267475-6f4h3cck 970 75 in in IN cord-267475-6f4h3cck 970 76 the the DT cord-267475-6f4h3cck 970 77 leader leader NN cord-267475-6f4h3cck 970 78 RNA RNA NNP cord-267475-6f4h3cck 970 79 of of IN cord-267475-6f4h3cck 970 80 Rous rous JJ cord-267475-6f4h3cck 970 81 sarcoma sarcoma NN cord-267475-6f4h3cck 970 82 virus virus NN cord-267475-6f4h3cck 970 83 Utilization utilization NN cord-267475-6f4h3cck 970 84 of of IN cord-267475-6f4h3cck 970 85 an an DT cord-267475-6f4h3cck 970 86 alternative alternative JJ cord-267475-6f4h3cck 970 87 transcription transcription NN cord-267475-6f4h3cck 970 88 initiation initiation NN cord-267475-6f4h3cck 970 89 site site NN cord-267475-6f4h3cck 970 90 of of IN cord-267475-6f4h3cck 970 91 somatic somatic JJ cord-267475-6f4h3cck 970 92 cytochrome cytochrome NN cord-267475-6f4h3cck 970 93 c c NN cord-267475-6f4h3cck 970 94 in in IN cord-267475-6f4h3cck 970 95 the the DT cord-267475-6f4h3cck 970 96 mouse mouse NN cord-267475-6f4h3cck 970 97 produces produce VBZ cord-267475-6f4h3cck 970 98 a a DT cord-267475-6f4h3cck 970 99 testisspecific testisspecific JJ cord-267475-6f4h3cck 970 100 cytochrome cytochrome NN cord-267475-6f4h3cck 970 101 c c NN cord-267475-6f4h3cck 971 1 mRNA mRNA NNP cord-267475-6f4h3cck 971 2 Heme Heme NNP cord-267475-6f4h3cck 971 3 - - HYPH cord-267475-6f4h3cck 971 4 regulated regulate VBN cord-267475-6f4h3cck 971 5 eIF2a eif2a JJ cord-267475-6f4h3cck 971 6 kinase kinase NN cord-267475-6f4h3cck 971 7 ( ( -LRB- cord-267475-6f4h3cck 971 8 HRI HRI NNP cord-267475-6f4h3cck 971 9 ) ) -RRB- cord-267475-6f4h3cck 971 10 is be VBZ cord-267475-6f4h3cck 971 11 required require VBN cord-267475-6f4h3cck 971 12 for for IN cord-267475-6f4h3cck 971 13 translational translational JJ cord-267475-6f4h3cck 971 14 regulation regulation NN cord-267475-6f4h3cck 971 15 and and CC cord-267475-6f4h3cck 971 16 survival survival NN cord-267475-6f4h3cck 971 17 of of IN cord-267475-6f4h3cck 971 18 erythroid erythroid JJ cord-267475-6f4h3cck 971 19 precursors precursor NNS cord-267475-6f4h3cck 971 20 in in IN cord-267475-6f4h3cck 971 21 iron iron NN cord-267475-6f4h3cck 971 22 deficiency deficiency NN cord-267475-6f4h3cck 971 23 Regulation regulation NN cord-267475-6f4h3cck 971 24 of of IN cord-267475-6f4h3cck 971 25 gene gene NN cord-267475-6f4h3cck 971 26 expression expression NN cord-267475-6f4h3cck 971 27 by by IN cord-267475-6f4h3cck 971 28 internal internal JJ cord-267475-6f4h3cck 971 29 ribosome ribosome NN cord-267475-6f4h3cck 971 30 entry entry NN cord-267475-6f4h3cck 971 31 sites site NNS cord-267475-6f4h3cck 971 32 or or CC cord-267475-6f4h3cck 971 33 cryptic cryptic JJ cord-267475-6f4h3cck 971 34 promoters promoter NNS cord-267475-6f4h3cck 971 35 : : : cord-267475-6f4h3cck 971 36 the the DT cord-267475-6f4h3cck 971 37 eIF4 eIF4 NNP cord-267475-6f4h3cck 971 38 G G NNP cord-267475-6f4h3cck 971 39 story story NN cord-267475-6f4h3cck 971 40 Human human JJ cord-267475-6f4h3cck 971 41 ubiquitin ubiquitin NN cord-267475-6f4h3cck 971 42 - - HYPH cord-267475-6f4h3cck 971 43 activating activate VBG cord-267475-6f4h3cck 971 44 enzyme enzyme NN cord-267475-6f4h3cck 971 45 , , , cord-267475-6f4h3cck 971 46 E1 E1 NNP cord-267475-6f4h3cck 971 47 . . . cord-267475-6f4h3cck 972 1 Indication indication NN cord-267475-6f4h3cck 972 2 of of IN cord-267475-6f4h3cck 972 3 potential potential JJ cord-267475-6f4h3cck 972 4 nuclear nuclear JJ cord-267475-6f4h3cck 972 5 and and CC cord-267475-6f4h3cck 972 6 cytoplasmic cytoplasmic JJ cord-267475-6f4h3cck 972 7 subpopulations subpopulation NNS cord-267475-6f4h3cck 972 8 using use VBG cord-267475-6f4h3cck 972 9 epitope epitope NN cord-267475-6f4h3cck 972 10 - - HYPH cord-267475-6f4h3cck 972 11 tagged tag VBN cord-267475-6f4h3cck 972 12 cDNA cdna NN cord-267475-6f4h3cck 972 13 constructs construct VBZ cord-267475-6f4h3cck 972 14 Abrogation abrogation NN cord-267475-6f4h3cck 972 15 of of IN cord-267475-6f4h3cck 972 16 upstream upstream JJ cord-267475-6f4h3cck 972 17 open open JJ cord-267475-6f4h3cck 972 18 reading reading NN cord-267475-6f4h3cck 972 19 frame frame NN cord-267475-6f4h3cck 972 20 - - HYPH cord-267475-6f4h3cck 972 21 mediated mediate VBN cord-267475-6f4h3cck 972 22 translational translational JJ cord-267475-6f4h3cck 972 23 control control NN cord-267475-6f4h3cck 972 24 of of IN cord-267475-6f4h3cck 972 25 a a DT cord-267475-6f4h3cck 972 26 plant plant NN cord-267475-6f4h3cck 972 27 S s NN cord-267475-6f4h3cck 972 28 - - HYPH cord-267475-6f4h3cck 972 29 adenosylmethionine adenosylmethionine NN cord-267475-6f4h3cck 972 30 decarboxylase decarboxylase NN cord-267475-6f4h3cck 972 31 results result NNS cord-267475-6f4h3cck 972 32 in in IN cord-267475-6f4h3cck 972 33 polyamine polyamine NN cord-267475-6f4h3cck 972 34 disruption disruption NN cord-267475-6f4h3cck 972 35 and and CC cord-267475-6f4h3cck 972 36 growth growth NN cord-267475-6f4h3cck 972 37 perturbations perturbation NNS cord-267475-6f4h3cck 972 38 Mouse Mouse NNP cord-267475-6f4h3cck 972 39 Atf5 Atf5 NNP cord-267475-6f4h3cck 972 40 : : : cord-267475-6f4h3cck 972 41 molecular molecular JJ cord-267475-6f4h3cck 972 42 cloning cloning NN cord-267475-6f4h3cck 972 43 of of IN cord-267475-6f4h3cck 972 44 two two CD cord-267475-6f4h3cck 972 45 novel novel NN cord-267475-6f4h3cck 972 46 mRNAs mrnas CD cord-267475-6f4h3cck 972 47 , , , cord-267475-6f4h3cck 972 48 genomic genomic JJ cord-267475-6f4h3cck 972 49 organization organization NN cord-267475-6f4h3cck 972 50 , , , cord-267475-6f4h3cck 972 51 and and CC cord-267475-6f4h3cck 972 52 odorant odorant NNP cord-267475-6f4h3cck 972 53 sensory sensory JJ cord-267475-6f4h3cck 972 54 neuron neuron NN cord-267475-6f4h3cck 972 55 localization localization NN cord-267475-6f4h3cck 972 56 Functionality Functionality NNP cord-267475-6f4h3cck 972 57 of of IN cord-267475-6f4h3cck 972 58 alternative alternative JJ cord-267475-6f4h3cck 972 59 splice splice NN cord-267475-6f4h3cck 972 60 forms form NNS cord-267475-6f4h3cck 972 61 of of IN cord-267475-6f4h3cck 972 62 the the DT cord-267475-6f4h3cck 972 63 first first JJ cord-267475-6f4h3cck 972 64 enzymes enzyme NNS cord-267475-6f4h3cck 972 65 involved involve VBN cord-267475-6f4h3cck 972 66 in in IN cord-267475-6f4h3cck 972 67 human human JJ cord-267475-6f4h3cck 972 68 molybdenum molybdenum NN cord-267475-6f4h3cck 972 69 cofactor cofactor NN cord-267475-6f4h3cck 972 70 biosynthesis biosynthesis NN cord-267475-6f4h3cck 972 71 Regulated regulate VBN cord-267475-6f4h3cck 972 72 translation translation NN cord-267475-6f4h3cck 972 73 initiation initiation NN cord-267475-6f4h3cck 972 74 controls control VBZ cord-267475-6f4h3cck 972 75 stress stress NN cord-267475-6f4h3cck 972 76 - - HYPH cord-267475-6f4h3cck 972 77 induced induce VBN cord-267475-6f4h3cck 972 78 gene gene NN cord-267475-6f4h3cck 972 79 expression expression NN cord-267475-6f4h3cck 972 80 in in IN cord-267475-6f4h3cck 972 81 mammalian mammalian JJ cord-267475-6f4h3cck 972 82 cells cell NNS cord-267475-6f4h3cck 972 83 Diabetes diabete VBZ cord-267475-6f4h3cck 972 84 mellitus mellitus NN cord-267475-6f4h3cck 972 85 and and CC cord-267475-6f4h3cck 972 86 exocrine exocrine JJ cord-267475-6f4h3cck 972 87 pancreatic pancreatic JJ cord-267475-6f4h3cck 972 88 dysfunction dysfunction NN cord-267475-6f4h3cck 972 89 in in IN cord-267475-6f4h3cck 972 90 Perk Perk NNP cord-267475-6f4h3cck 973 1 2 2 LS cord-267475-6f4h3cck 973 2 /2 /2 CD cord-267475-6f4h3cck 973 3 mice mouse NNS cord-267475-6f4h3cck 973 4 reveals reveal VBZ cord-267475-6f4h3cck 973 5 a a DT cord-267475-6f4h3cck 973 6 role role NN cord-267475-6f4h3cck 973 7 for for IN cord-267475-6f4h3cck 973 8 translational translational JJ cord-267475-6f4h3cck 973 9 control control NN cord-267475-6f4h3cck 973 10 in in IN cord-267475-6f4h3cck 973 11 secretory secretory JJ cord-267475-6f4h3cck 973 12 cell cell NN cord-267475-6f4h3cck 973 13 survival survival NN cord-267475-6f4h3cck 973 14 Characterization characterization NN cord-267475-6f4h3cck 973 15 of of IN cord-267475-6f4h3cck 973 16 two two CD cord-267475-6f4h3cck 973 17 cis cis JJ cord-267475-6f4h3cck 973 18 - - HYPH cord-267475-6f4h3cck 973 19 regulatory regulatory JJ cord-267475-6f4h3cck 973 20 regions region NNS cord-267475-6f4h3cck 973 21 in in IN cord-267475-6f4h3cck 973 22 the the DT cord-267475-6f4h3cck 973 23 murine murine NN cord-267475-6f4h3cck 973 24 b1,4-galactosyltransferase b1,4-galactosyltransferase NNP cord-267475-6f4h3cck 973 25 gene gene NN cord-267475-6f4h3cck 974 1 A a DT cord-267475-6f4h3cck 974 2 cis cis NN cord-267475-6f4h3cck 974 3 - - HYPH cord-267475-6f4h3cck 974 4 acting act VBG cord-267475-6f4h3cck 974 5 element element NN cord-267475-6f4h3cck 974 6 in in IN cord-267475-6f4h3cck 974 7 the the DT cord-267475-6f4h3cck 974 8 BCL-2 BCL-2 NNP cord-267475-6f4h3cck 974 9 gene gene NN cord-267475-6f4h3cck 974 10 controls control VBZ cord-267475-6f4h3cck 974 11 expression expression NN cord-267475-6f4h3cck 974 12 through through IN cord-267475-6f4h3cck 974 13 translational translational JJ cord-267475-6f4h3cck 974 14 mechanisms mechanism NNS cord-267475-6f4h3cck 975 1 Subcellular subcellular JJ cord-267475-6f4h3cck 975 2 relocalization relocalization NN cord-267475-6f4h3cck 975 3 of of IN cord-267475-6f4h3cck 975 4 a a DT cord-267475-6f4h3cck 975 5 long long JJ cord-267475-6f4h3cck 975 6 - - HYPH cord-267475-6f4h3cck 975 7 chain chain NN cord-267475-6f4h3cck 975 8 fatty fatty JJ cord-267475-6f4h3cck 975 9 acid acid NN cord-267475-6f4h3cck 975 10 CoA coa NN cord-267475-6f4h3cck 975 11 ligase ligase NN cord-267475-6f4h3cck 975 12 by by IN cord-267475-6f4h3cck 975 13 a a DT cord-267475-6f4h3cck 975 14 suppressor suppressor NN cord-267475-6f4h3cck 975 15 mutation mutation NN cord-267475-6f4h3cck 975 16 alleviates alleviate VBZ cord-267475-6f4h3cck 975 17 a a DT cord-267475-6f4h3cck 975 18 respiration respiration NN cord-267475-6f4h3cck 975 19 deficiency deficiency NN cord-267475-6f4h3cck 975 20 in in IN cord-267475-6f4h3cck 975 21 Saccharomyces Saccharomyces NNP cord-267475-6f4h3cck 975 22 cerevisiae cerevisiae VBZ cord-267475-6f4h3cck 975 23 Translation translation NN cord-267475-6f4h3cck 975 24 initiation initiation NN cord-267475-6f4h3cck 975 25 start start VB cord-267475-6f4h3cck 975 26 prediction prediction NN cord-267475-6f4h3cck 975 27 in in IN cord-267475-6f4h3cck 975 28 human human NN cord-267475-6f4h3cck 975 29 cDNAs cdna NNS cord-267475-6f4h3cck 975 30 with with IN cord-267475-6f4h3cck 975 31 high high JJ cord-267475-6f4h3cck 975 32 accuracy accuracy NN cord-267475-6f4h3cck 975 33 Upflp Upflp NNP cord-267475-6f4h3cck 975 34 , , , cord-267475-6f4h3cck 975 35 Nmd2p Nmd2p NNP cord-267475-6f4h3cck 975 36 , , , cord-267475-6f4h3cck 975 37 and and CC cord-267475-6f4h3cck 975 38 Upf3p upf3p RB cord-267475-6f4h3cck 975 39 regulate regulate VB cord-267475-6f4h3cck 975 40 the the DT cord-267475-6f4h3cck 975 41 decapping decapping NN cord-267475-6f4h3cck 975 42 and and CC cord-267475-6f4h3cck 975 43 exonucleolytic exonucleolytic JJ cord-267475-6f4h3cck 975 44 degradation degradation NN cord-267475-6f4h3cck 975 45 of of IN cord-267475-6f4h3cck 975 46 both both DT cord-267475-6f4h3cck 975 47 nonsense nonsense NN cord-267475-6f4h3cck 975 48 - - HYPH cord-267475-6f4h3cck 975 49 containing contain VBG cord-267475-6f4h3cck 975 50 mRNAs mRNAs NNPS cord-267475-6f4h3cck 975 51 and and CC cord-267475-6f4h3cck 975 52 wild wild JJ cord-267475-6f4h3cck 975 53 - - HYPH cord-267475-6f4h3cck 975 54 type type NN cord-267475-6f4h3cck 975 55 mRNAs mrnas CD cord-267475-6f4h3cck 976 1 Human Human NNP cord-267475-6f4h3cck 976 2 wig-1 wig-1 NNP cord-267475-6f4h3cck 976 3 , , , cord-267475-6f4h3cck 976 4 a a DT cord-267475-6f4h3cck 976 5 p53 p53 NN cord-267475-6f4h3cck 976 6 target target NN cord-267475-6f4h3cck 976 7 gene gene NN cord-267475-6f4h3cck 976 8 that that WDT cord-267475-6f4h3cck 976 9 encodes encode VBZ cord-267475-6f4h3cck 976 10 a a DT cord-267475-6f4h3cck 976 11 growth growth NN cord-267475-6f4h3cck 976 12 inhibitory inhibitory JJ cord-267475-6f4h3cck 976 13 zinc zinc NN cord-267475-6f4h3cck 976 14 finger finger NN cord-267475-6f4h3cck 976 15 protein protein NN cord-267475-6f4h3cck 976 16 Internal internal JJ cord-267475-6f4h3cck 976 17 ribosome ribosome NN cord-267475-6f4h3cck 976 18 entry entry NN cord-267475-6f4h3cck 976 19 sites site NNS cord-267475-6f4h3cck 976 20 in in IN cord-267475-6f4h3cck 976 21 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 976 22 mRNA mRNA NNP cord-267475-6f4h3cck 976 23 molecules molecule NNS cord-267475-6f4h3cck 976 24 Composition composition NN cord-267475-6f4h3cck 976 25 and and CC cord-267475-6f4h3cck 976 26 arrangement arrangement NN cord-267475-6f4h3cck 976 27 of of IN cord-267475-6f4h3cck 976 28 genes gene NNS cord-267475-6f4h3cck 976 29 define define VBP cord-267475-6f4h3cck 976 30 the the DT cord-267475-6f4h3cck 976 31 strength strength NN cord-267475-6f4h3cck 976 32 of of IN cord-267475-6f4h3cck 976 33 IRES IRES NNP cord-267475-6f4h3cck 976 34 - - HYPH cord-267475-6f4h3cck 976 35 driven drive VBN cord-267475-6f4h3cck 976 36 translation translation NN cord-267475-6f4h3cck 976 37 in in IN cord-267475-6f4h3cck 976 38 bicistronic bicistronic NNP cord-267475-6f4h3cck 976 39 mRNAs mRNAs . cord-267475-6f4h3cck 977 1 The the DT cord-267475-6f4h3cck 977 2 conserved conserved JJ cord-267475-6f4h3cck 977 3 5 5 CD cord-267475-6f4h3cck 977 4 0 0 CD cord-267475-6f4h3cck 977 5 -untranslated -untranslated JJ cord-267475-6f4h3cck 977 6 leader leader NN cord-267475-6f4h3cck 977 7 of of IN cord-267475-6f4h3cck 977 8 Spi-1 Spi-1 NNP cord-267475-6f4h3cck 977 9 ( ( -LRB- cord-267475-6f4h3cck 977 10 PU.1 PU.1 NNP cord-267475-6f4h3cck 977 11 ) ) -RRB- cord-267475-6f4h3cck 978 1 mRNA mRNA NNP cord-267475-6f4h3cck 978 2 is be VBZ cord-267475-6f4h3cck 978 3 highly highly RB cord-267475-6f4h3cck 978 4 structured structured JJ cord-267475-6f4h3cck 978 5 and and CC cord-267475-6f4h3cck 978 6 potently potently RB cord-267475-6f4h3cck 978 7 inhibits inhibit VBZ cord-267475-6f4h3cck 978 8 translation translation NN cord-267475-6f4h3cck 978 9 in in IN cord-267475-6f4h3cck 978 10 vitro vitro FW cord-267475-6f4h3cck 978 11 but but CC cord-267475-6f4h3cck 978 12 not not RB cord-267475-6f4h3cck 978 13 in in IN cord-267475-6f4h3cck 978 14 vivo vivo NNP cord-267475-6f4h3cck 978 15 Detection detection NN cord-267475-6f4h3cck 978 16 of of IN cord-267475-6f4h3cck 978 17 the the DT cord-267475-6f4h3cck 978 18 ORF3 ORF3 NNP cord-267475-6f4h3cck 978 19 polypeptide polypeptide NN cord-267475-6f4h3cck 978 20 of of IN cord-267475-6f4h3cck 978 21 feline feline JJ cord-267475-6f4h3cck 978 22 calicivirus calicivirus NN cord-267475-6f4h3cck 978 23 in in IN cord-267475-6f4h3cck 978 24 infected infected JJ cord-267475-6f4h3cck 978 25 cells cell NNS cord-267475-6f4h3cck 978 26 and and CC cord-267475-6f4h3cck 978 27 evidence evidence NN cord-267475-6f4h3cck 978 28 for for IN cord-267475-6f4h3cck 978 29 its -PRON- PRP$ cord-267475-6f4h3cck 978 30 expression expression NN cord-267475-6f4h3cck 978 31 from from IN cord-267475-6f4h3cck 978 32 a a DT cord-267475-6f4h3cck 978 33 single single JJ cord-267475-6f4h3cck 978 34 , , , cord-267475-6f4h3cck 978 35 functionally functionally RB cord-267475-6f4h3cck 978 36 bicistronic bicistronic JJ cord-267475-6f4h3cck 978 37 subgenomic subgenomic NNP cord-267475-6f4h3cck 979 1 mRNA mRNA NNP cord-267475-6f4h3cck 980 1 An an DT cord-267475-6f4h3cck 980 2 altered altered JJ cord-267475-6f4h3cck 980 3 ribosomal ribosomal JJ cord-267475-6f4h3cck 980 4 protein protein NN cord-267475-6f4h3cck 980 5 in in IN cord-267475-6f4h3cck 980 6 an an DT cord-267475-6f4h3cck 980 7 edeine edeine NN cord-267475-6f4h3cck 980 8 - - HYPH cord-267475-6f4h3cck 980 9 resistant resistant JJ cord-267475-6f4h3cck 980 10 mutant mutant NN cord-267475-6f4h3cck 980 11 of of IN cord-267475-6f4h3cck 980 12 Saccharomyces Saccharomyces NNP cord-267475-6f4h3cck 980 13 cerevisiae cerevisiae VBZ cord-267475-6f4h3cck 980 14 Translation translation NN cord-267475-6f4h3cck 980 15 of of IN cord-267475-6f4h3cck 980 16 the the DT cord-267475-6f4h3cck 980 17 second second JJ cord-267475-6f4h3cck 980 18 gene gene NN cord-267475-6f4h3cck 980 19 of of IN cord-267475-6f4h3cck 980 20 peanut peanut NN cord-267475-6f4h3cck 980 21 clump clump NN cord-267475-6f4h3cck 980 22 virus virus NN cord-267475-6f4h3cck 980 23 RNA RNA NNP cord-267475-6f4h3cck 980 24 2 2 CD cord-267475-6f4h3cck 980 25 occurs occur VBZ cord-267475-6f4h3cck 980 26 by by IN cord-267475-6f4h3cck 980 27 leaky leaky JJ cord-267475-6f4h3cck 980 28 scanning scanning NN cord-267475-6f4h3cck 980 29 in in IN cord-267475-6f4h3cck 980 30 vitro vitro FW cord-267475-6f4h3cck 980 31 Characterization characterization NN cord-267475-6f4h3cck 980 32 of of IN cord-267475-6f4h3cck 980 33 the the DT cord-267475-6f4h3cck 980 34 gene gene NN cord-267475-6f4h3cck 980 35 encoding encode VBG cord-267475-6f4h3cck 980 36 human human JJ cord-267475-6f4h3cck 980 37 platelet platelet NN cord-267475-6f4h3cck 980 38 glycoprotein glycoprotein NN cord-267475-6f4h3cck 980 39 IX IX NNP cord-267475-6f4h3cck 980 40 Translational Translational NNP cord-267475-6f4h3cck 980 41 regulation regulation NN cord-267475-6f4h3cck 980 42 of of IN cord-267475-6f4h3cck 980 43 yeast yeast NN cord-267475-6f4h3cck 980 44 GCN4 GCN4 NNP cord-267475-6f4h3cck 980 45 . . . cord-267475-6f4h3cck 981 1 A a DT cord-267475-6f4h3cck 981 2 window window NN cord-267475-6f4h3cck 981 3 on on IN cord-267475-6f4h3cck 981 4 factors factor NNS cord-267475-6f4h3cck 981 5 that that WDT cord-267475-6f4h3cck 981 6 control control VBP cord-267475-6f4h3cck 981 7 initiator initiator NN cord-267475-6f4h3cck 981 8 - - HYPH cord-267475-6f4h3cck 981 9 tRNA trna NN cord-267475-6f4h3cck 981 10 binding bind VBG cord-267475-6f4h3cck 981 11 to to IN cord-267475-6f4h3cck 981 12 the the DT cord-267475-6f4h3cck 981 13 ribosome ribosome NN cord-267475-6f4h3cck 981 14 Translation translation NN cord-267475-6f4h3cck 981 15 initiation initiation NN cord-267475-6f4h3cck 981 16 and and CC cord-267475-6f4h3cck 981 17 assembly assembly NN cord-267475-6f4h3cck 981 18 of of IN cord-267475-6f4h3cck 981 19 peripherin peripherin NNP cord-267475-6f4h3cck 981 20 in in IN cord-267475-6f4h3cck 981 21 cultured cultured JJ cord-267475-6f4h3cck 981 22 cells cell NNS cord-267475-6f4h3cck 982 1 A a DT cord-267475-6f4h3cck 982 2 translationattenuating translationattenuating NN cord-267475-6f4h3cck 982 3 intraleader intraleader NN cord-267475-6f4h3cck 982 4 open open JJ cord-267475-6f4h3cck 982 5 reading reading NN cord-267475-6f4h3cck 982 6 frame frame NN cord-267475-6f4h3cck 982 7 is be VBZ cord-267475-6f4h3cck 982 8 selected select VBN cord-267475-6f4h3cck 982 9 on on IN cord-267475-6f4h3cck 982 10 coronavirus coronavirus NN cord-267475-6f4h3cck 983 1 mRNAs mrnas WDT cord-267475-6f4h3cck 983 2 during during IN cord-267475-6f4h3cck 983 3 persistent persistent JJ cord-267475-6f4h3cck 983 4 infection infection NN cord-267475-6f4h3cck 983 5 Molecular molecular JJ cord-267475-6f4h3cck 983 6 basis basis NN cord-267475-6f4h3cck 983 7 for for IN cord-267475-6f4h3cck 983 8 the the DT cord-267475-6f4h3cck 983 9 dual dual JJ cord-267475-6f4h3cck 983 10 mitochondrial mitochondrial NN cord-267475-6f4h3cck 983 11 and and CC cord-267475-6f4h3cck 983 12 cytosolic cytosolic JJ cord-267475-6f4h3cck 983 13 localization localization NN cord-267475-6f4h3cck 983 14 of of IN cord-267475-6f4h3cck 983 15 alanine alanine NN cord-267475-6f4h3cck 983 16 : : : cord-267475-6f4h3cck 984 1 glyoxylate glyoxylate NNP cord-267475-6f4h3cck 984 2 aminotransferase aminotransferase NN cord-267475-6f4h3cck 984 3 in in IN cord-267475-6f4h3cck 984 4 amphibian amphibian NN cord-267475-6f4h3cck 984 5 liver liver NN cord-267475-6f4h3cck 984 6 cells cell NNS cord-267475-6f4h3cck 984 7 Pim-1 Pim-1 NNP cord-267475-6f4h3cck 984 8 protein protein NN cord-267475-6f4h3cck 984 9 expression expression NN cord-267475-6f4h3cck 984 10 is be VBZ cord-267475-6f4h3cck 984 11 regulated regulate VBN cord-267475-6f4h3cck 984 12 by by IN cord-267475-6f4h3cck 984 13 its -PRON- PRP$ cord-267475-6f4h3cck 984 14 5 5 CD cord-267475-6f4h3cck 984 15 0 0 CD cord-267475-6f4h3cck 984 16 -untranslated -untranslated JJ cord-267475-6f4h3cck 984 17 region region NN cord-267475-6f4h3cck 984 18 and and CC cord-267475-6f4h3cck 984 19 translation translation NN cord-267475-6f4h3cck 984 20 initiation initiation NN cord-267475-6f4h3cck 984 21 factor factor NN cord-267475-6f4h3cck 984 22 eIF-4E eIF-4E . cord-267475-6f4h3cck 984 23 Characterization characterization NN cord-267475-6f4h3cck 984 24 of of IN cord-267475-6f4h3cck 984 25 the the DT cord-267475-6f4h3cck 984 26 infections infection NNS cord-267475-6f4h3cck 984 27 of of IN cord-267475-6f4h3cck 984 28 permissive permissive JJ cord-267475-6f4h3cck 984 29 and and CC cord-267475-6f4h3cck 984 30 nonpermissive nonpermissive JJ cord-267475-6f4h3cck 984 31 cells cell NNS cord-267475-6f4h3cck 984 32 by by IN cord-267475-6f4h3cck 984 33 host host NN cord-267475-6f4h3cck 984 34 range range NN cord-267475-6f4h3cck 984 35 mutants mutant NNS cord-267475-6f4h3cck 984 36 of of IN cord-267475-6f4h3cck 984 37 vesicular vesicular JJ cord-267475-6f4h3cck 984 38 stomatitis stomatitis NN cord-267475-6f4h3cck 984 39 virus virus NN cord-267475-6f4h3cck 984 40 defective defective JJ cord-267475-6f4h3cck 984 41 in in IN cord-267475-6f4h3cck 984 42 RNA RNA NNP cord-267475-6f4h3cck 984 43 methylation methylation NN cord-267475-6f4h3cck 984 44 Translational translational JJ cord-267475-6f4h3cck 984 45 regulation regulation NN cord-267475-6f4h3cck 984 46 of of IN cord-267475-6f4h3cck 984 47 complement complement JJ cord-267475-6f4h3cck 984 48 protein protein NN cord-267475-6f4h3cck 984 49 C2 C2 NNP cord-267475-6f4h3cck 984 50 expression expression NN cord-267475-6f4h3cck 984 51 by by IN cord-267475-6f4h3cck 984 52 differential differential JJ cord-267475-6f4h3cck 984 53 utilization utilization NN cord-267475-6f4h3cck 984 54 of of IN cord-267475-6f4h3cck 984 55 the the DT cord-267475-6f4h3cck 984 56 5 5 CD cord-267475-6f4h3cck 984 57 0 0 CD cord-267475-6f4h3cck 984 58 -untranslated -untranslated JJ cord-267475-6f4h3cck 984 59 region region NN cord-267475-6f4h3cck 984 60 of of IN cord-267475-6f4h3cck 984 61 mRNA mRNA NNP cord-267475-6f4h3cck 984 62 Multiple multiple JJ cord-267475-6f4h3cck 984 63 elements element NNS cord-267475-6f4h3cck 984 64 in in IN cord-267475-6f4h3cck 984 65 the the DT cord-267475-6f4h3cck 984 66 5 5 CD cord-267475-6f4h3cck 984 67 0 0 CD cord-267475-6f4h3cck 984 68 untranslated untranslated JJ cord-267475-6f4h3cck 984 69 region region NN cord-267475-6f4h3cck 984 70 down down RB cord-267475-6f4h3cck 984 71 - - HYPH cord-267475-6f4h3cck 984 72 regulate regulate VB cord-267475-6f4h3cck 984 73 c c NN cord-267475-6f4h3cck 984 74 - - HYPH cord-267475-6f4h3cck 984 75 sis sis NNP cord-267475-6f4h3cck 984 76 messenger messenger NNP cord-267475-6f4h3cck 984 77 RNA RNA NNP cord-267475-6f4h3cck 984 78 translation translation NN cord-267475-6f4h3cck 984 79 Caenorhabditis Caenorhabditis NNP cord-267475-6f4h3cck 984 80 elegans elegan NNS cord-267475-6f4h3cck 984 81 mRNAs mrna VBD cord-267475-6f4h3cck 984 82 that that WDT cord-267475-6f4h3cck 984 83 encode encode VBP cord-267475-6f4h3cck 984 84 a a DT cord-267475-6f4h3cck 984 85 protein protein NN cord-267475-6f4h3cck 984 86 similar similar JJ cord-267475-6f4h3cck 984 87 to to IN cord-267475-6f4h3cck 984 88 ADARs adar NNS cord-267475-6f4h3cck 984 89 derive derive VB cord-267475-6f4h3cck 984 90 from from IN cord-267475-6f4h3cck 984 91 an an DT cord-267475-6f4h3cck 984 92 operon operon NN cord-267475-6f4h3cck 984 93 containing contain VBG cord-267475-6f4h3cck 984 94 six six CD cord-267475-6f4h3cck 984 95 genes gene NNS cord-267475-6f4h3cck 984 96 b b LS cord-267475-6f4h3cck 984 97 - - : cord-267475-6f4h3cck 984 98 Cateninsensitive Cateninsensitive NNP cord-267475-6f4h3cck 984 99 isoforms isoform NNS cord-267475-6f4h3cck 984 100 of of IN cord-267475-6f4h3cck 984 101 lymphoid lymphoid JJ cord-267475-6f4h3cck 984 102 enhancer enhancer NN cord-267475-6f4h3cck 984 103 factor-1 factor-1 NNP cord-267475-6f4h3cck 984 104 are be VBP cord-267475-6f4h3cck 984 105 selectively selectively RB cord-267475-6f4h3cck 984 106 expressed express VBN cord-267475-6f4h3cck 984 107 in in IN cord-267475-6f4h3cck 984 108 colon colon NN cord-267475-6f4h3cck 984 109 cancer cancer NN cord-267475-6f4h3cck 984 110 Rh Rh NNP cord-267475-6f4h3cck 984 111 mod mod NN cord-267475-6f4h3cck 984 112 syndrome syndrome NN cord-267475-6f4h3cck 984 113 : : : cord-267475-6f4h3cck 985 1 a a DT cord-267475-6f4h3cck 985 2 family family NN cord-267475-6f4h3cck 985 3 study study NN cord-267475-6f4h3cck 985 4 of of IN cord-267475-6f4h3cck 985 5 the the DT cord-267475-6f4h3cck 985 6 translation translation NN cord-267475-6f4h3cck 985 7 - - HYPH cord-267475-6f4h3cck 985 8 initiator initiator NN cord-267475-6f4h3cck 985 9 mutation mutation NN cord-267475-6f4h3cck 985 10 in in IN cord-267475-6f4h3cck 985 11 the the DT cord-267475-6f4h3cck 985 12 Rh50 Rh50 NNP cord-267475-6f4h3cck 985 13 glycoprotein glycoprotein NN cord-267475-6f4h3cck 985 14 gene gene NN cord-267475-6f4h3cck 985 15 GTP GTP NNP cord-267475-6f4h3cck 985 16 hydrolysis hydrolysis NN cord-267475-6f4h3cck 985 17 controls control VBZ cord-267475-6f4h3cck 985 18 stringent stringent JJ cord-267475-6f4h3cck 985 19 selection selection NN cord-267475-6f4h3cck 985 20 of of IN cord-267475-6f4h3cck 985 21 the the DT cord-267475-6f4h3cck 985 22 AUG AUG NNP cord-267475-6f4h3cck 985 23 start start NN cord-267475-6f4h3cck 985 24 codon codon NN cord-267475-6f4h3cck 985 25 during during IN cord-267475-6f4h3cck 985 26 translation translation NN cord-267475-6f4h3cck 985 27 initiation initiation NN cord-267475-6f4h3cck 985 28 in in IN cord-267475-6f4h3cck 985 29 Saccharomyces Saccharomyces NNP cord-267475-6f4h3cck 985 30 cerevisiae cerevisiae VBZ cord-267475-6f4h3cck 985 31 Genomic genomic JJ cord-267475-6f4h3cck 985 32 structure structure NN cord-267475-6f4h3cck 985 33 of of IN cord-267475-6f4h3cck 985 34 the the DT cord-267475-6f4h3cck 985 35 locus locus NN cord-267475-6f4h3cck 985 36 encoding encode VBG cord-267475-6f4h3cck 985 37 protein protein NN cord-267475-6f4h3cck 985 38 4.1 4.1 CD cord-267475-6f4h3cck 985 39 . . . cord-267475-6f4h3cck 986 1 Structural structural JJ cord-267475-6f4h3cck 986 2 basis basis NN cord-267475-6f4h3cck 986 3 for for IN cord-267475-6f4h3cck 986 4 complex complex JJ cord-267475-6f4h3cck 986 5 combinatorial combinatorial JJ cord-267475-6f4h3cck 986 6 patterns pattern NNS cord-267475-6f4h3cck 986 7 of of IN cord-267475-6f4h3cck 986 8 tissue tissue NN cord-267475-6f4h3cck 986 9 - - HYPH cord-267475-6f4h3cck 986 10 specific specific JJ cord-267475-6f4h3cck 986 11 alternative alternative JJ cord-267475-6f4h3cck 986 12 RNA rna NN cord-267475-6f4h3cck 986 13 splicing splicing NN cord-267475-6f4h3cck 986 14 Restriction Restriction NNP cord-267475-6f4h3cck 986 15 of of IN cord-267475-6f4h3cck 986 16 fusion fusion NN cord-267475-6f4h3cck 986 17 protein protein NN cord-267475-6f4h3cck 986 18 mRNA mRNA NNP cord-267475-6f4h3cck 986 19 as as IN cord-267475-6f4h3cck 986 20 a a DT cord-267475-6f4h3cck 986 21 mechanism mechanism NN cord-267475-6f4h3cck 986 22 of of IN cord-267475-6f4h3cck 986 23 measles measle NNS cord-267475-6f4h3cck 986 24 virus virus NN cord-267475-6f4h3cck 986 25 persistence persistence NN cord-267475-6f4h3cck 986 26 Messenger Messenger NNP cord-267475-6f4h3cck 986 27 RNA RNA NNP cord-267475-6f4h3cck 986 28 for for IN cord-267475-6f4h3cck 986 29 the the DT cord-267475-6f4h3cck 986 30 coat coat NN cord-267475-6f4h3cck 986 31 protein protein NN cord-267475-6f4h3cck 986 32 of of IN cord-267475-6f4h3cck 986 33 tobacco tobacco NN cord-267475-6f4h3cck 986 34 mosaic mosaic NNP cord-267475-6f4h3cck 986 35 virus virus NN cord-267475-6f4h3cck 986 36 Multiple multiple JJ cord-267475-6f4h3cck 986 37 5 5 CD cord-267475-6f4h3cck 986 38 0 0 CD cord-267475-6f4h3cck 987 1 -untranslated -untranslated JJ cord-267475-6f4h3cck 987 2 exons exon NNS cord-267475-6f4h3cck 987 3 in in IN cord-267475-6f4h3cck 987 4 the the DT cord-267475-6f4h3cck 987 5 nuclear nuclear JJ cord-267475-6f4h3cck 987 6 respiratory respiratory JJ cord-267475-6f4h3cck 987 7 factor factor NN cord-267475-6f4h3cck 987 8 1 1 CD cord-267475-6f4h3cck 987 9 gene gene NN cord-267475-6f4h3cck 987 10 span span NN cord-267475-6f4h3cck 987 11 47 47 CD cord-267475-6f4h3cck 987 12 kb kb NNP cord-267475-6f4h3cck 987 13 and and CC cord-267475-6f4h3cck 987 14 contribute contribute VB cord-267475-6f4h3cck 987 15 to to IN cord-267475-6f4h3cck 987 16 transcript transcript NN cord-267475-6f4h3cck 987 17 heterogeneity heterogeneity NN cord-267475-6f4h3cck 987 18 and and CC cord-267475-6f4h3cck 987 19 translational translational JJ cord-267475-6f4h3cck 987 20 efficiency efficiency NN cord-267475-6f4h3cck 988 1 Translational translational JJ cord-267475-6f4h3cck 988 2 regulation regulation NN cord-267475-6f4h3cck 988 3 of of IN cord-267475-6f4h3cck 988 4 hepatitis hepatitis NN cord-267475-6f4h3cck 988 5 B B NNP cord-267475-6f4h3cck 988 6 virus virus NN cord-267475-6f4h3cck 988 7 polymerase polymerase NN cord-267475-6f4h3cck 988 8 gene gene NN cord-267475-6f4h3cck 988 9 by by IN cord-267475-6f4h3cck 988 10 termination termination NN cord-267475-6f4h3cck 988 11 - - HYPH cord-267475-6f4h3cck 988 12 reinitiation reinitiation NN cord-267475-6f4h3cck 988 13 of of IN cord-267475-6f4h3cck 988 14 an an DT cord-267475-6f4h3cck 988 15 upstream upstream JJ cord-267475-6f4h3cck 988 16 minicistron minicistron NN cord-267475-6f4h3cck 988 17 in in IN cord-267475-6f4h3cck 988 18 a a DT cord-267475-6f4h3cck 988 19 length length NN cord-267475-6f4h3cck 988 20 - - HYPH cord-267475-6f4h3cck 988 21 dependent dependent JJ cord-267475-6f4h3cck 988 22 manner manner NN cord-267475-6f4h3cck 989 1 pVHL pVHL NNP cord-267475-6f4h3cck 989 2 19 19 CD cord-267475-6f4h3cck 989 3 is be VBZ cord-267475-6f4h3cck 989 4 a a DT cord-267475-6f4h3cck 989 5 biologically biologically RB cord-267475-6f4h3cck 989 6 active active JJ cord-267475-6f4h3cck 989 7 product product NN cord-267475-6f4h3cck 989 8 of of IN cord-267475-6f4h3cck 989 9 the the DT cord-267475-6f4h3cck 989 10 von von NNP cord-267475-6f4h3cck 989 11 Hippel Hippel NNP cord-267475-6f4h3cck 989 12 - - HYPH cord-267475-6f4h3cck 989 13 Lindau Lindau NNP cord-267475-6f4h3cck 989 14 gene gene NN cord-267475-6f4h3cck 989 15 arising arise VBG cord-267475-6f4h3cck 989 16 from from IN cord-267475-6f4h3cck 989 17 internal internal JJ cord-267475-6f4h3cck 989 18 translation translation NN cord-267475-6f4h3cck 989 19 initiation initiation NN cord-267475-6f4h3cck 989 20 Conservation Conservation NNP cord-267475-6f4h3cck 989 21 of of IN cord-267475-6f4h3cck 989 22 polyamine polyamine NN cord-267475-6f4h3cck 989 23 regulation regulation NN cord-267475-6f4h3cck 989 24 by by IN cord-267475-6f4h3cck 989 25 translational translational JJ cord-267475-6f4h3cck 989 26 frameshifting frameshifting NN cord-267475-6f4h3cck 989 27 from from IN cord-267475-6f4h3cck 989 28 yeast yeast NN cord-267475-6f4h3cck 989 29 to to IN cord-267475-6f4h3cck 989 30 mammals mammal NNS cord-267475-6f4h3cck 989 31 Identification identification NN cord-267475-6f4h3cck 989 32 of of IN cord-267475-6f4h3cck 989 33 two two CD cord-267475-6f4h3cck 989 34 additional additional JJ cord-267475-6f4h3cck 989 35 translation translation NN cord-267475-6f4h3cck 989 36 products product NNS cord-267475-6f4h3cck 989 37 from from IN cord-267475-6f4h3cck 989 38 the the DT cord-267475-6f4h3cck 989 39 matrix matrix NN cord-267475-6f4h3cck 989 40 ( ( -LRB- cord-267475-6f4h3cck 989 41 M M NNP cord-267475-6f4h3cck 989 42 ) ) -RRB- cord-267475-6f4h3cck 989 43 gene gene NN cord-267475-6f4h3cck 989 44 that that WDT cord-267475-6f4h3cck 989 45 contribute contribute VBP cord-267475-6f4h3cck 989 46 to to IN cord-267475-6f4h3cck 989 47 vesicular vesicular JJ cord-267475-6f4h3cck 989 48 stomatitis stomatitis NN cord-267475-6f4h3cck 989 49 virus virus NN cord-267475-6f4h3cck 989 50 cytopathology cytopathology NN cord-267475-6f4h3cck 989 51 Decreased decrease VBD cord-267475-6f4h3cck 989 52 RIZ1 RIZ1 NNP cord-267475-6f4h3cck 989 53 expression expression NN cord-267475-6f4h3cck 989 54 but but CC cord-267475-6f4h3cck 989 55 not not RB cord-267475-6f4h3cck 989 56 RIZ2 RIZ2 NNP cord-267475-6f4h3cck 989 57 in in IN cord-267475-6f4h3cck 989 58 hepatoma hepatoma NNP cord-267475-6f4h3cck 989 59 and and CC cord-267475-6f4h3cck 989 60 suppression suppression NN cord-267475-6f4h3cck 989 61 of of IN cord-267475-6f4h3cck 989 62 hepatoma hepatoma NNP cord-267475-6f4h3cck 989 63 tumorigenicity tumorigenicity NN cord-267475-6f4h3cck 989 64 by by IN cord-267475-6f4h3cck 989 65 RIZ1 RIZ1 NNP cord-267475-6f4h3cck 989 66 Variants Variants NNPS cord-267475-6f4h3cck 989 67 of of IN cord-267475-6f4h3cck 989 68 the the DT cord-267475-6f4h3cck 989 69 5 5 CD cord-267475-6f4h3cck 989 70 0 0 CD cord-267475-6f4h3cck 989 71 -untranslated -untranslated JJ cord-267475-6f4h3cck 989 72 region region NN cord-267475-6f4h3cck 989 73 of of IN cord-267475-6f4h3cck 989 74 the the DT cord-267475-6f4h3cck 989 75 bovine bovine JJ cord-267475-6f4h3cck 989 76 growth growth NN cord-267475-6f4h3cck 989 77 hormone hormone NN cord-267475-6f4h3cck 989 78 receptor receptor NN cord-267475-6f4h3cck 989 79 mRNA mrna NN cord-267475-6f4h3cck 989 80 : : : cord-267475-6f4h3cck 989 81 isolation isolation NN cord-267475-6f4h3cck 989 82 , , , cord-267475-6f4h3cck 989 83 expression expression NN cord-267475-6f4h3cck 989 84 and and CC cord-267475-6f4h3cck 989 85 effects effect NNS cord-267475-6f4h3cck 989 86 on on IN cord-267475-6f4h3cck 989 87 translational translational JJ cord-267475-6f4h3cck 989 88 efficiency efficiency NN cord-267475-6f4h3cck 989 89 Minimal minimal JJ cord-267475-6f4h3cck 989 90 truncation truncation NN cord-267475-6f4h3cck 989 91 of of IN cord-267475-6f4h3cck 989 92 the the DT cord-267475-6f4h3cck 989 93 c c NNP cord-267475-6f4h3cck 989 94 - - HYPH cord-267475-6f4h3cck 989 95 myb myb NNP cord-267475-6f4h3cck 989 96 gene gene NN cord-267475-6f4h3cck 989 97 product product NN cord-267475-6f4h3cck 989 98 in in IN cord-267475-6f4h3cck 989 99 rapid rapid JJ cord-267475-6f4h3cck 989 100 - - HYPH cord-267475-6f4h3cck 989 101 onset onset NN cord-267475-6f4h3cck 989 102 B b NN cord-267475-6f4h3cck 989 103 - - HYPH cord-267475-6f4h3cck 989 104 cell cell NN cord-267475-6f4h3cck 989 105 lymphoma lymphoma NN cord-267475-6f4h3cck 990 1 Both both DT cord-267475-6f4h3cck 990 2 codon codon NN cord-267475-6f4h3cck 990 3 context context NN cord-267475-6f4h3cck 990 4 and and CC cord-267475-6f4h3cck 990 5 leader leader NN cord-267475-6f4h3cck 990 6 length length NN cord-267475-6f4h3cck 990 7 contribute contribute VB cord-267475-6f4h3cck 990 8 to to IN cord-267475-6f4h3cck 990 9 efficient efficient JJ cord-267475-6f4h3cck 990 10 expression expression NN cord-267475-6f4h3cck 990 11 of of IN cord-267475-6f4h3cck 990 12 two two CD cord-267475-6f4h3cck 990 13 overlapping overlap VBG cord-267475-6f4h3cck 990 14 open open JJ cord-267475-6f4h3cck 990 15 reading reading NN cord-267475-6f4h3cck 990 16 frames frame NNS cord-267475-6f4h3cck 990 17 of of IN cord-267475-6f4h3cck 990 18 a a DT cord-267475-6f4h3cck 990 19 cucumber cucumber NN cord-267475-6f4h3cck 990 20 necrosis necrosis NN cord-267475-6f4h3cck 990 21 virus virus NN cord-267475-6f4h3cck 990 22 bifunctional bifunctional JJ cord-267475-6f4h3cck 990 23 subgenomic subgenomic NNP cord-267475-6f4h3cck 991 1 mRNA mRNA NNP cord-267475-6f4h3cck 991 2 Expression Expression NNP cord-267475-6f4h3cck 991 3 of of IN cord-267475-6f4h3cck 991 4 bacterial bacterial JJ cord-267475-6f4h3cck 991 5 chitinase chitinase NNP cord-267475-6f4h3cck 991 6 protein protein NN cord-267475-6f4h3cck 991 7 in in IN cord-267475-6f4h3cck 991 8 tobacco tobacco NN cord-267475-6f4h3cck 991 9 leaves leave NNS cord-267475-6f4h3cck 991 10 using use VBG cord-267475-6f4h3cck 991 11 two two CD cord-267475-6f4h3cck 991 12 photosynthetic photosynthetic JJ cord-267475-6f4h3cck 991 13 gene gene NN cord-267475-6f4h3cck 991 14 promoters promoter NNS cord-267475-6f4h3cck 991 15 N N NNP cord-267475-6f4h3cck 991 16 - - HYPH cord-267475-6f4h3cck 991 17 myc myc NNP cord-267475-6f4h3cck 991 18 translation translation NN cord-267475-6f4h3cck 991 19 is be VBZ cord-267475-6f4h3cck 991 20 initiated initiate VBN cord-267475-6f4h3cck 991 21 via via IN cord-267475-6f4h3cck 991 22 an an DT cord-267475-6f4h3cck 991 23 internal internal JJ cord-267475-6f4h3cck 991 24 ribosome ribosome NN cord-267475-6f4h3cck 991 25 entry entry NN cord-267475-6f4h3cck 991 26 segment segment NN cord-267475-6f4h3cck 991 27 that that WDT cord-267475-6f4h3cck 991 28 displays display VBZ cord-267475-6f4h3cck 991 29 enhanced enhanced JJ cord-267475-6f4h3cck 991 30 activity activity NN cord-267475-6f4h3cck 991 31 in in IN cord-267475-6f4h3cck 991 32 neuronal neuronal JJ cord-267475-6f4h3cck 991 33 cells cell NNS cord-267475-6f4h3cck 991 34 Expression expression NN cord-267475-6f4h3cck 991 35 of of IN cord-267475-6f4h3cck 991 36 human human JJ cord-267475-6f4h3cck 991 37 foamy foamy NN cord-267475-6f4h3cck 991 38 virus virus NN cord-267475-6f4h3cck 991 39 reverse reverse NN cord-267475-6f4h3cck 991 40 transcriptase transcriptase NN cord-267475-6f4h3cck 991 41 involves involve VBZ cord-267475-6f4h3cck 991 42 a a DT cord-267475-6f4h3cck 991 43 spliced splice VBN cord-267475-6f4h3cck 991 44 pol pol NN cord-267475-6f4h3cck 991 45 mRNA mrna NN cord-267475-6f4h3cck 991 46 A a DT cord-267475-6f4h3cck 991 47 common common JJ cord-267475-6f4h3cck 991 48 genetic genetic JJ cord-267475-6f4h3cck 991 49 polymorphism polymorphism NN cord-267475-6f4h3cck 991 50 ( ( -LRB- cord-267475-6f4h3cck 991 51 46 46 CD cord-267475-6f4h3cck 991 52 C c NN cord-267475-6f4h3cck 991 53 to to IN cord-267475-6f4h3cck 991 54 T t NN cord-267475-6f4h3cck 991 55 substitution substitution NN cord-267475-6f4h3cck 991 56 ) ) -RRB- cord-267475-6f4h3cck 991 57 in in IN cord-267475-6f4h3cck 991 58 the the DT cord-267475-6f4h3cck 991 59 5 5 CD cord-267475-6f4h3cck 991 60 0 0 CD cord-267475-6f4h3cck 991 61 -untranslated -untranslated JJ cord-267475-6f4h3cck 991 62 region region NN cord-267475-6f4h3cck 991 63 of of IN cord-267475-6f4h3cck 991 64 the the DT cord-267475-6f4h3cck 991 65 coagulation coagulation NN cord-267475-6f4h3cck 991 66 factor factor NN cord-267475-6f4h3cck 991 67 XII XII NNP cord-267475-6f4h3cck 991 68 gene gene NN cord-267475-6f4h3cck 991 69 is be VBZ cord-267475-6f4h3cck 991 70 associated associate VBN cord-267475-6f4h3cck 991 71 with with IN cord-267475-6f4h3cck 991 72 low low JJ cord-267475-6f4h3cck 991 73 translation translation NN cord-267475-6f4h3cck 991 74 efficiency efficiency NN cord-267475-6f4h3cck 991 75 and and CC cord-267475-6f4h3cck 991 76 decrease decrease NN cord-267475-6f4h3cck 991 77 in in IN cord-267475-6f4h3cck 991 78 plasma plasma NN cord-267475-6f4h3cck 991 79 factor factor NN cord-267475-6f4h3cck 991 80 XII xii NN cord-267475-6f4h3cck 991 81 level level NN cord-267475-6f4h3cck 991 82 Production production NN cord-267475-6f4h3cck 991 83 of of IN cord-267475-6f4h3cck 991 84 three three CD cord-267475-6f4h3cck 991 85 distinct distinct JJ cord-267475-6f4h3cck 991 86 mRNAs mrna NNS cord-267475-6f4h3cck 991 87 of of IN cord-267475-6f4h3cck 991 88 150 150 CD cord-267475-6f4h3cck 991 89 kDa kDa NNS cord-267475-6f4h3cck 991 90 oxygen oxygen NN cord-267475-6f4h3cck 991 91 - - HYPH cord-267475-6f4h3cck 991 92 regulated regulate VBN cord-267475-6f4h3cck 991 93 protein protein NN cord-267475-6f4h3cck 991 94 ( ( -LRB- cord-267475-6f4h3cck 991 95 ORP150 ORP150 NNP cord-267475-6f4h3cck 991 96 ) ) -RRB- cord-267475-6f4h3cck 991 97 by by IN cord-267475-6f4h3cck 991 98 alternative alternative JJ cord-267475-6f4h3cck 991 99 promoters promoter NNS cord-267475-6f4h3cck 991 100 : : : cord-267475-6f4h3cck 991 101 preferential preferential JJ cord-267475-6f4h3cck 991 102 induction induction NN cord-267475-6f4h3cck 991 103 of of IN cord-267475-6f4h3cck 991 104 one one CD cord-267475-6f4h3cck 991 105 species specie NNS cord-267475-6f4h3cck 991 106 under under IN cord-267475-6f4h3cck 991 107 stress stress NN cord-267475-6f4h3cck 991 108 conditions condition NNS cord-267475-6f4h3cck 992 1 Two two CD cord-267475-6f4h3cck 992 2 distinct distinct JJ cord-267475-6f4h3cck 992 3 estrogen estrogen NN cord-267475-6f4h3cck 992 4 - - HYPH cord-267475-6f4h3cck 992 5 regulated regulate VBN cord-267475-6f4h3cck 992 6 promoters promoter NNS cord-267475-6f4h3cck 992 7 generate generate VBP cord-267475-6f4h3cck 992 8 transcripts transcript NNS cord-267475-6f4h3cck 992 9 encoding encode VBG cord-267475-6f4h3cck 992 10 the the DT cord-267475-6f4h3cck 992 11 two two CD cord-267475-6f4h3cck 992 12 functionally functionally RB cord-267475-6f4h3cck 992 13 different different JJ cord-267475-6f4h3cck 992 14 human human JJ cord-267475-6f4h3cck 992 15 progesterone progesterone NN cord-267475-6f4h3cck 992 16 receptor receptor NN cord-267475-6f4h3cck 992 17 forms form VBZ cord-267475-6f4h3cck 992 18 A A NNP cord-267475-6f4h3cck 992 19 and and CC cord-267475-6f4h3cck 992 20 B B NNP cord-267475-6f4h3cck 992 21 Transient transient JJ cord-267475-6f4h3cck 992 22 expression expression NN cord-267475-6f4h3cck 992 23 of of IN cord-267475-6f4h3cck 992 24 human human JJ cord-267475-6f4h3cck 992 25 and and CC cord-267475-6f4h3cck 992 26 chicken chicken NN cord-267475-6f4h3cck 992 27 progesterone progesterone NN cord-267475-6f4h3cck 992 28 receptors receptor NNS cord-267475-6f4h3cck 992 29 does do VBZ cord-267475-6f4h3cck 992 30 not not RB cord-267475-6f4h3cck 992 31 support support VB cord-267475-6f4h3cck 992 32 alternative alternative JJ cord-267475-6f4h3cck 992 33 translational translational JJ cord-267475-6f4h3cck 992 34 initiation initiation NN cord-267475-6f4h3cck 992 35 from from IN cord-267475-6f4h3cck 992 36 a a DT cord-267475-6f4h3cck 992 37 single single JJ cord-267475-6f4h3cck 992 38 mRNA mrna NN cord-267475-6f4h3cck 992 39 as as IN cord-267475-6f4h3cck 992 40 the the DT cord-267475-6f4h3cck 992 41 mechanism mechanism NN cord-267475-6f4h3cck 992 42 generating generate VBG cord-267475-6f4h3cck 992 43 two two CD cord-267475-6f4h3cck 992 44 receptor receptor NN cord-267475-6f4h3cck 992 45 isoforms isoform NNS cord-267475-6f4h3cck 992 46 Human Human NNP cord-267475-6f4h3cck 992 47 RNA RNA NNP cord-267475-6f4h3cck 992 48 - - HYPH cord-267475-6f4h3cck 992 49 specific specific JJ cord-267475-6f4h3cck 992 50 adenosine adenosine NN cord-267475-6f4h3cck 992 51 deaminase deaminase XX cord-267475-6f4h3cck 993 1 ( ( -LRB- cord-267475-6f4h3cck 993 2 ADAR1 ADAR1 NNP cord-267475-6f4h3cck 993 3 ) ) -RRB- cord-267475-6f4h3cck 993 4 gene gene NN cord-267475-6f4h3cck 993 5 specifies specify VBZ cord-267475-6f4h3cck 993 6 transcripts transcript NNS cord-267475-6f4h3cck 993 7 that that WDT cord-267475-6f4h3cck 993 8 initiate initiate VBP cord-267475-6f4h3cck 993 9 from from IN cord-267475-6f4h3cck 993 10 a a DT cord-267475-6f4h3cck 993 11 constitutively constitutively RB cord-267475-6f4h3cck 993 12 active active JJ cord-267475-6f4h3cck 993 13 alternative alternative JJ cord-267475-6f4h3cck 993 14 promoter promoter NN cord-267475-6f4h3cck 993 15 RNA RNA NNP cord-267475-6f4h3cck 993 16 targets target NNS cord-267475-6f4h3cck 993 17 of of IN cord-267475-6f4h3cck 993 18 the the DT cord-267475-6f4h3cck 993 19 fragile fragile JJ cord-267475-6f4h3cck 993 20 X x NN cord-267475-6f4h3cck 993 21 protein protein NN cord-267475-6f4h3cck 993 22 Molecular molecular JJ cord-267475-6f4h3cck 993 23 cloning cloning NN cord-267475-6f4h3cck 993 24 of of IN cord-267475-6f4h3cck 993 25 the the DT cord-267475-6f4h3cck 993 26 human human JJ cord-267475-6f4h3cck 993 27 p120 p120 NNP cord-267475-6f4h3cck 993 28 ctn ctn NNP cord-267475-6f4h3cck 993 29 catenin catenin NNP cord-267475-6f4h3cck 993 30 gene gene NNP cord-267475-6f4h3cck 993 31 ( ( -LRB- cord-267475-6f4h3cck 993 32 CTNND1 ctnnd1 NN cord-267475-6f4h3cck 993 33 ) ) -RRB- cord-267475-6f4h3cck 993 34 : : : cord-267475-6f4h3cck 993 35 expression expression NN cord-267475-6f4h3cck 993 36 of of IN cord-267475-6f4h3cck 993 37 multiple multiple JJ cord-267475-6f4h3cck 993 38 alternatively alternatively RB cord-267475-6f4h3cck 993 39 spliced splice VBN cord-267475-6f4h3cck 993 40 isoforms isoform NNS cord-267475-6f4h3cck 993 41 Competition Competition NNP cord-267475-6f4h3cck 993 42 between between IN cord-267475-6f4h3cck 993 43 nuclear nuclear JJ cord-267475-6f4h3cck 993 44 localization localization NN cord-267475-6f4h3cck 993 45 and and CC cord-267475-6f4h3cck 993 46 secretory secretory NN cord-267475-6f4h3cck 993 47 signals signal NNS cord-267475-6f4h3cck 993 48 determines determine VBZ cord-267475-6f4h3cck 993 49 the the DT cord-267475-6f4h3cck 993 50 subcellular subcellular JJ cord-267475-6f4h3cck 993 51 fate fate NN cord-267475-6f4h3cck 993 52 of of IN cord-267475-6f4h3cck 993 53 a a DT cord-267475-6f4h3cck 993 54 single single JJ cord-267475-6f4h3cck 993 55 CUG CUG NNP cord-267475-6f4h3cck 993 56 - - HYPH cord-267475-6f4h3cck 993 57 initiated initiate VBN cord-267475-6f4h3cck 993 58 form form NN cord-267475-6f4h3cck 993 59 of of IN cord-267475-6f4h3cck 993 60 FGF3 FGF3 NNP cord-267475-6f4h3cck 993 61 Expression Expression NNP cord-267475-6f4h3cck 993 62 of of IN cord-267475-6f4h3cck 993 63 the the DT cord-267475-6f4h3cck 993 64 open open JJ cord-267475-6f4h3cck 993 65 reading reading NN cord-267475-6f4h3cck 993 66 frame frame NN cord-267475-6f4h3cck 993 67 74 74 CD cord-267475-6f4h3cck 993 68 ( ( -LRB- cord-267475-6f4h3cck 993 69 G g NN cord-267475-6f4h3cck 993 70 - - HYPH cord-267475-6f4h3cck 993 71 protein protein NN cord-267475-6f4h3cck 993 72 - - HYPH cord-267475-6f4h3cck 993 73 coupled couple VBN cord-267475-6f4h3cck 993 74 receptor receptor NN cord-267475-6f4h3cck 993 75 ) ) -RRB- cord-267475-6f4h3cck 993 76 gene gene NN cord-267475-6f4h3cck 993 77 of of IN cord-267475-6f4h3cck 993 78 Kaposi Kaposi NNP cord-267475-6f4h3cck 993 79 's 's POS cord-267475-6f4h3cck 993 80 sarcoma sarcoma NN cord-267475-6f4h3cck 993 81 ( ( -LRB- cord-267475-6f4h3cck 993 82 KS)-associated ks)-associated CD cord-267475-6f4h3cck 993 83 herpesvirus herpesvirus NN cord-267475-6f4h3cck 993 84 : : : cord-267475-6f4h3cck 993 85 implications implication NNS cord-267475-6f4h3cck 993 86 for for IN cord-267475-6f4h3cck 993 87 KS KS NNP cord-267475-6f4h3cck 993 88 pathogenesis pathogenesis NN cord-267475-6f4h3cck 993 89 Splicing splicing NN cord-267475-6f4h3cck 993 90 of of IN cord-267475-6f4h3cck 993 91 cauliflower cauliflower NN cord-267475-6f4h3cck 993 92 mosaic mosaic JJ cord-267475-6f4h3cck 993 93 virus virus NN cord-267475-6f4h3cck 993 94 35S 35S NNP cord-267475-6f4h3cck 993 95 RNA RNA NNP cord-267475-6f4h3cck 993 96 is be VBZ cord-267475-6f4h3cck 993 97 essential essential JJ cord-267475-6f4h3cck 993 98 for for IN cord-267475-6f4h3cck 993 99 viral viral JJ cord-267475-6f4h3cck 993 100 infectivity infectivity NN cord-267475-6f4h3cck 993 101 Two two CD cord-267475-6f4h3cck 993 102 overlapping overlap VBG cord-267475-6f4h3cck 993 103 reading reading NN cord-267475-6f4h3cck 993 104 frames frame NNS cord-267475-6f4h3cck 993 105 in in IN cord-267475-6f4h3cck 993 106 a a DT cord-267475-6f4h3cck 993 107 single single JJ cord-267475-6f4h3cck 993 108 exon exon NN cord-267475-6f4h3cck 993 109 encode encode NN cord-267475-6f4h3cck 993 110 interacting interact VBG cord-267475-6f4h3cck 993 111 proteins protein NNS cord-267475-6f4h3cck 993 112 -a -a : cord-267475-6f4h3cck 993 113 novel novel JJ cord-267475-6f4h3cck 993 114 way way NN cord-267475-6f4h3cck 993 115 of of IN cord-267475-6f4h3cck 993 116 gene gene NN cord-267475-6f4h3cck 993 117 usage usage NN cord-267475-6f4h3cck 993 118 Murine murine JJ cord-267475-6f4h3cck 993 119 phospholipid phospholipid NN cord-267475-6f4h3cck 993 120 hydroperoxide hydroperoxide NN cord-267475-6f4h3cck 993 121 glutathione glutathione NN cord-267475-6f4h3cck 993 122 peroxidase peroxidase NN cord-267475-6f4h3cck 993 123 : : : cord-267475-6f4h3cck 993 124 cDNA cdna NN cord-267475-6f4h3cck 993 125 sequence sequence NN cord-267475-6f4h3cck 993 126 , , , cord-267475-6f4h3cck 993 127 tissue tissue NN cord-267475-6f4h3cck 993 128 expression expression NN cord-267475-6f4h3cck 993 129 , , , cord-267475-6f4h3cck 993 130 and and CC cord-267475-6f4h3cck 993 131 mapping map VBG cord-267475-6f4h3cck 993 132 A a DT cord-267475-6f4h3cck 993 133 positive positive JJ cord-267475-6f4h3cck 993 134 - - HYPH cord-267475-6f4h3cck 993 135 strand strand NN cord-267475-6f4h3cck 993 136 RNA RNA NNP cord-267475-6f4h3cck 993 137 virus virus NN cord-267475-6f4h3cck 993 138 with with IN cord-267475-6f4h3cck 993 139 three three CD cord-267475-6f4h3cck 993 140 very very RB cord-267475-6f4h3cck 993 141 different different JJ cord-267475-6f4h3cck 993 142 subgenomic subgenomic NNP cord-267475-6f4h3cck 993 143 RNA RNA NNP cord-267475-6f4h3cck 993 144 promoters promoter NNS cord-267475-6f4h3cck 993 145 Caveolin-1 Caveolin-1 NNP cord-267475-6f4h3cck 993 146 isoforms isoform NNS cord-267475-6f4h3cck 993 147 are be VBP cord-267475-6f4h3cck 993 148 encoded encode VBN cord-267475-6f4h3cck 993 149 by by IN cord-267475-6f4h3cck 993 150 distinct distinct JJ cord-267475-6f4h3cck 993 151 mRNAs mrna NNS cord-267475-6f4h3cck 994 1 The the DT cord-267475-6f4h3cck 994 2 position position NN cord-267475-6f4h3cck 994 3 dependence dependence NN cord-267475-6f4h3cck 994 4 of of IN cord-267475-6f4h3cck 994 5 translational translational JJ cord-267475-6f4h3cck 994 6 regulation regulation NN cord-267475-6f4h3cck 994 7 via via IN cord-267475-6f4h3cck 994 8 RNA RNA NNP cord-267475-6f4h3cck 994 9 - - HYPH cord-267475-6f4h3cck 994 10 RNA RNA NNP cord-267475-6f4h3cck 994 11 and and CC cord-267475-6f4h3cck 994 12 RNAprotein RNAprotein NNP cord-267475-6f4h3cck 994 13 interactions interaction NNS cord-267475-6f4h3cck 994 14 in in IN cord-267475-6f4h3cck 994 15 the the DT cord-267475-6f4h3cck 994 16 5 5 CD cord-267475-6f4h3cck 994 17 0 0 CD cord-267475-6f4h3cck 994 18 -untranslated -untranslated JJ cord-267475-6f4h3cck 994 19 region region NN cord-267475-6f4h3cck 994 20 of of IN cord-267475-6f4h3cck 994 21 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 994 22 mRNA mRNA NNP cord-267475-6f4h3cck 994 23 is be VBZ cord-267475-6f4h3cck 994 24 a a DT cord-267475-6f4h3cck 994 25 function function NN cord-267475-6f4h3cck 994 26 of of IN cord-267475-6f4h3cck 994 27 the the DT cord-267475-6f4h3cck 994 28 thermodynamic thermodynamic JJ cord-267475-6f4h3cck 994 29 competence competence NN cord-267475-6f4h3cck 994 30 of of IN cord-267475-6f4h3cck 994 31 40S 40s CD cord-267475-6f4h3cck 994 32 ribosomes ribosome NNS cord-267475-6f4h3cck 994 33 in in IN cord-267475-6f4h3cck 994 34 translational translational JJ cord-267475-6f4h3cck 994 35 initiation initiation NN cord-267475-6f4h3cck 994 36 Binding Binding NNP cord-267475-6f4h3cck 994 37 of of IN cord-267475-6f4h3cck 994 38 ribosomes ribosome NNS cord-267475-6f4h3cck 994 39 to to TO cord-267475-6f4h3cck 994 40 linear linear JJ cord-267475-6f4h3cck 994 41 and and CC cord-267475-6f4h3cck 994 42 circular circular JJ cord-267475-6f4h3cck 994 43 forms form NNS cord-267475-6f4h3cck 994 44 of of IN cord-267475-6f4h3cck 994 45 the the DT cord-267475-6f4h3cck 994 46 5 5 CD cord-267475-6f4h3cck 994 47 0 0 CD cord-267475-6f4h3cck 994 48 -terminal -terminal JJ cord-267475-6f4h3cck 994 49 leader leader NN cord-267475-6f4h3cck 994 50 fragment fragment NN cord-267475-6f4h3cck 994 51 of of IN cord-267475-6f4h3cck 994 52 tobacco tobacco NN cord-267475-6f4h3cck 994 53 mosaic mosaic NNP cord-267475-6f4h3cck 994 54 virus virus NN cord-267475-6f4h3cck 994 55 RNA RNA NNP cord-267475-6f4h3cck 994 56 Familial familial JJ cord-267475-6f4h3cck 994 57 essential essential JJ cord-267475-6f4h3cck 994 58 thrombocythemia thrombocythemia NN cord-267475-6f4h3cck 994 59 associated associate VBN cord-267475-6f4h3cck 994 60 with with IN cord-267475-6f4h3cck 994 61 one one CD cord-267475-6f4h3cck 994 62 - - HYPH cord-267475-6f4h3cck 994 63 base base NN cord-267475-6f4h3cck 994 64 deletion deletion NN cord-267475-6f4h3cck 994 65 in in IN cord-267475-6f4h3cck 994 66 the the DT cord-267475-6f4h3cck 994 67 5 5 CD cord-267475-6f4h3cck 994 68 0 0 CD cord-267475-6f4h3cck 994 69 -untranslated -untranslated JJ cord-267475-6f4h3cck 994 70 region region NN cord-267475-6f4h3cck 994 71 of of IN cord-267475-6f4h3cck 994 72 the the DT cord-267475-6f4h3cck 994 73 thrombopoietin thrombopoietin NNP cord-267475-6f4h3cck 994 74 gene gene NN cord-267475-6f4h3cck 994 75 Upstream upstream IN cord-267475-6f4h3cck 994 76 open open JJ cord-267475-6f4h3cck 994 77 reading reading NN cord-267475-6f4h3cck 994 78 frames frame NNS cord-267475-6f4h3cck 994 79 regulate regulate VBP cord-267475-6f4h3cck 994 80 the the DT cord-267475-6f4h3cck 994 81 translation translation NN cord-267475-6f4h3cck 994 82 of of IN cord-267475-6f4h3cck 994 83 multiple multiple JJ cord-267475-6f4h3cck 994 84 mRNA mRNA NNP cord-267475-6f4h3cck 994 85 variants variant NNS cord-267475-6f4h3cck 994 86 of of IN cord-267475-6f4h3cck 994 87 the the DT cord-267475-6f4h3cck 994 88 estrogen estrogen NN cord-267475-6f4h3cck 994 89 receptor receptor NN cord-267475-6f4h3cck 994 90 alpha alpha NN cord-267475-6f4h3cck 994 91 Independent Independent NNP cord-267475-6f4h3cck 994 92 promoters promoter NNS cord-267475-6f4h3cck 994 93 regulate regulate VBP cord-267475-6f4h3cck 994 94 the the DT cord-267475-6f4h3cck 994 95 expression expression NN cord-267475-6f4h3cck 994 96 of of IN cord-267475-6f4h3cck 994 97 two two CD cord-267475-6f4h3cck 994 98 amino amino NNS cord-267475-6f4h3cck 994 99 terminally terminally RB cord-267475-6f4h3cck 994 100 distinct distinct JJ cord-267475-6f4h3cck 994 101 forms form NNS cord-267475-6f4h3cck 994 102 of of IN cord-267475-6f4h3cck 994 103 latent latent JJ cord-267475-6f4h3cck 994 104 transforming transform VBG cord-267475-6f4h3cck 994 105 growth growth NN cord-267475-6f4h3cck 994 106 factor factor NN cord-267475-6f4h3cck 994 107 - - HYPH cord-267475-6f4h3cck 994 108 b b NN cord-267475-6f4h3cck 994 109 binding bind VBG cord-267475-6f4h3cck 994 110 protein-1 protein-1 NNP cord-267475-6f4h3cck 994 111 ( ( -LRB- cord-267475-6f4h3cck 994 112 LTBP-1 LTBP-1 NNP cord-267475-6f4h3cck 994 113 ) ) -RRB- cord-267475-6f4h3cck 994 114 in in IN cord-267475-6f4h3cck 994 115 a a DT cord-267475-6f4h3cck 994 116 cell cell NN cord-267475-6f4h3cck 994 117 typespecific typespecific NN cord-267475-6f4h3cck 994 118 manner manner NN cord-267475-6f4h3cck 994 119 Inability Inability NNP cord-267475-6f4h3cck 994 120 of of IN cord-267475-6f4h3cck 994 121 circular circular JJ cord-267475-6f4h3cck 994 122 mRNA mrna NN cord-267475-6f4h3cck 994 123 to to TO cord-267475-6f4h3cck 994 124 attach attach VB cord-267475-6f4h3cck 994 125 to to IN cord-267475-6f4h3cck 994 126 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 994 127 ribosomes ribosome NNS cord-267475-6f4h3cck 994 128 Migration migration NN cord-267475-6f4h3cck 994 129 of of IN cord-267475-6f4h3cck 994 130 40S 40s CD cord-267475-6f4h3cck 994 131 ribosomal ribosomal JJ cord-267475-6f4h3cck 994 132 subunits subunit NNS cord-267475-6f4h3cck 994 133 on on IN cord-267475-6f4h3cck 994 134 messenger messenger NN cord-267475-6f4h3cck 994 135 RNA RNA NNP cord-267475-6f4h3cck 994 136 when when WRB cord-267475-6f4h3cck 994 137 initiation initiation NN cord-267475-6f4h3cck 994 138 is be VBZ cord-267475-6f4h3cck 994 139 perturbed perturb VBN cord-267475-6f4h3cck 994 140 by by IN cord-267475-6f4h3cck 994 141 lowering lower VBG cord-267475-6f4h3cck 994 142 magnesium magnesium NN cord-267475-6f4h3cck 994 143 or or CC cord-267475-6f4h3cck 994 144 adding add VBG cord-267475-6f4h3cck 994 145 drugs drug NNS cord-267475-6f4h3cck 994 146 Role role NN cord-267475-6f4h3cck 994 147 of of IN cord-267475-6f4h3cck 994 148 ATP ATP NNP cord-267475-6f4h3cck 994 149 in in IN cord-267475-6f4h3cck 994 150 binding binding NN cord-267475-6f4h3cck 994 151 and and CC cord-267475-6f4h3cck 994 152 migration migration NN cord-267475-6f4h3cck 994 153 of of IN cord-267475-6f4h3cck 994 154 40S 40s CD cord-267475-6f4h3cck 994 155 ribosomal ribosomal JJ cord-267475-6f4h3cck 994 156 subunits subunit NNS cord-267475-6f4h3cck 994 157 Analysis Analysis NNP cord-267475-6f4h3cck 994 158 of of IN cord-267475-6f4h3cck 994 159 ribosome ribosome NN cord-267475-6f4h3cck 994 160 binding binding NN cord-267475-6f4h3cck 994 161 sites site NNS cord-267475-6f4h3cck 994 162 from from IN cord-267475-6f4h3cck 994 163 the the DT cord-267475-6f4h3cck 994 164 s1 s1 NNP cord-267475-6f4h3cck 994 165 message message NN cord-267475-6f4h3cck 994 166 of of IN cord-267475-6f4h3cck 994 167 reovirus reovirus NNP cord-267475-6f4h3cck 994 168 . . . cord-267475-6f4h3cck 995 1 Initiation initiation NN cord-267475-6f4h3cck 995 2 at at IN cord-267475-6f4h3cck 995 3 the the DT cord-267475-6f4h3cck 995 4 first first JJ cord-267475-6f4h3cck 995 5 and and CC cord-267475-6f4h3cck 995 6 second second JJ cord-267475-6f4h3cck 995 7 AUG AUG NNP cord-267475-6f4h3cck 995 8 codons codon NNS cord-267475-6f4h3cck 995 9 Translation translation NN cord-267475-6f4h3cck 995 10 of of IN cord-267475-6f4h3cck 995 11 insulin insulin NN cord-267475-6f4h3cck 995 12 - - HYPH cord-267475-6f4h3cck 995 13 related relate VBN cord-267475-6f4h3cck 995 14 polypeptides polypeptide NNS cord-267475-6f4h3cck 995 15 from from IN cord-267475-6f4h3cck 995 16 messenger messenger NN cord-267475-6f4h3cck 995 17 RNAs rna NNS cord-267475-6f4h3cck 995 18 with with IN cord-267475-6f4h3cck 995 19 tandemly tandemly NNP cord-267475-6f4h3cck 995 20 reiterated reiterate VBD cord-267475-6f4h3cck 995 21 copies copy NNS cord-267475-6f4h3cck 995 22 of of IN cord-267475-6f4h3cck 995 23 the the DT cord-267475-6f4h3cck 995 24 ribosome ribosome NN cord-267475-6f4h3cck 995 25 binding bind VBG cord-267475-6f4h3cck 995 26 site site NN cord-267475-6f4h3cck 995 27 Influences Influences NNPS cord-267475-6f4h3cck 995 28 of of IN cord-267475-6f4h3cck 995 29 mRNA mRNA NNP cord-267475-6f4h3cck 995 30 secondary secondary JJ cord-267475-6f4h3cck 995 31 structure structure NN cord-267475-6f4h3cck 995 32 on on IN cord-267475-6f4h3cck 995 33 initiation initiation NN cord-267475-6f4h3cck 995 34 by by IN cord-267475-6f4h3cck 995 35 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 995 36 ribosomes ribosome NNS cord-267475-6f4h3cck 995 37 Point Point NNP cord-267475-6f4h3cck 995 38 mutations mutation NNS cord-267475-6f4h3cck 995 39 define define VBP cord-267475-6f4h3cck 995 40 a a DT cord-267475-6f4h3cck 995 41 sequence sequence NN cord-267475-6f4h3cck 995 42 flanking flank VBG cord-267475-6f4h3cck 995 43 the the DT cord-267475-6f4h3cck 995 44 AUG AUG NNP cord-267475-6f4h3cck 995 45 initiator initiator NN cord-267475-6f4h3cck 995 46 codon codon NN cord-267475-6f4h3cck 995 47 that that WDT cord-267475-6f4h3cck 995 48 modulates modulate VBZ cord-267475-6f4h3cck 995 49 translation translation NN cord-267475-6f4h3cck 995 50 by by IN cord-267475-6f4h3cck 995 51 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 995 52 ribosomes ribosome NNS cord-267475-6f4h3cck 996 1 An an DT cord-267475-6f4h3cck 996 2 analysis analysis NN cord-267475-6f4h3cck 996 3 of of IN cord-267475-6f4h3cck 996 4 5 5 CD cord-267475-6f4h3cck 996 5 0 0 CD cord-267475-6f4h3cck 996 6 -noncoding -noncoding NN cord-267475-6f4h3cck 996 7 sequences sequence NNS cord-267475-6f4h3cck 996 8 from from IN cord-267475-6f4h3cck 996 9 699 699 CD cord-267475-6f4h3cck 996 10 vertebrate vertebrate JJ cord-267475-6f4h3cck 996 11 messenger messenger NN cord-267475-6f4h3cck 996 12 RNAs rna NNS cord-267475-6f4h3cck 996 13 At at IN cord-267475-6f4h3cck 996 14 least least JJS cord-267475-6f4h3cck 996 15 six six CD cord-267475-6f4h3cck 996 16 nucleotides nucleotide NNS cord-267475-6f4h3cck 996 17 preceding precede VBG cord-267475-6f4h3cck 996 18 the the DT cord-267475-6f4h3cck 996 19 AUG AUG NNP cord-267475-6f4h3cck 996 20 initiator initiator NN cord-267475-6f4h3cck 996 21 codon codon NN cord-267475-6f4h3cck 996 22 enhance enhance VB cord-267475-6f4h3cck 996 23 translation translation NN cord-267475-6f4h3cck 996 24 in in IN cord-267475-6f4h3cck 996 25 mammalian mammalian JJ cord-267475-6f4h3cck 996 26 cells cell NNS cord-267475-6f4h3cck 996 27 Effects effect NNS cord-267475-6f4h3cck 996 28 of of IN cord-267475-6f4h3cck 996 29 intercistronic intercistronic JJ cord-267475-6f4h3cck 996 30 length length NN cord-267475-6f4h3cck 996 31 on on IN cord-267475-6f4h3cck 996 32 the the DT cord-267475-6f4h3cck 996 33 efficiency efficiency NN cord-267475-6f4h3cck 996 34 of of IN cord-267475-6f4h3cck 996 35 reinitiation reinitiation NN cord-267475-6f4h3cck 996 36 by by IN cord-267475-6f4h3cck 996 37 eucaryotic eucaryotic JJ cord-267475-6f4h3cck 996 38 ribosomes ribosome NNS cord-267475-6f4h3cck 996 39 Circumstances circumstance NNS cord-267475-6f4h3cck 996 40 and and CC cord-267475-6f4h3cck 996 41 mechanisms mechanism NNS cord-267475-6f4h3cck 996 42 of of IN cord-267475-6f4h3cck 996 43 inhibition inhibition NN cord-267475-6f4h3cck 996 44 of of IN cord-267475-6f4h3cck 996 45 translation translation NN cord-267475-6f4h3cck 996 46 by by IN cord-267475-6f4h3cck 996 47 secondary secondary JJ cord-267475-6f4h3cck 996 48 structure structure NN cord-267475-6f4h3cck 996 49 in in IN cord-267475-6f4h3cck 996 50 eucaryotic eucaryotic JJ cord-267475-6f4h3cck 996 51 mRNAs mrnas CD cord-267475-6f4h3cck 996 52 Downstream downstream JJ cord-267475-6f4h3cck 996 53 secondary secondary JJ cord-267475-6f4h3cck 996 54 structure structure NN cord-267475-6f4h3cck 996 55 facilitates facilitate VBZ cord-267475-6f4h3cck 996 56 recognition recognition NN cord-267475-6f4h3cck 996 57 of of IN cord-267475-6f4h3cck 996 58 initiator initiator NN cord-267475-6f4h3cck 996 59 codons codon NNS cord-267475-6f4h3cck 996 60 by by IN cord-267475-6f4h3cck 996 61 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 996 62 ribosomes ribosome NNS cord-267475-6f4h3cck 996 63 Evaluation Evaluation NNP cord-267475-6f4h3cck 996 64 of of IN cord-267475-6f4h3cck 996 65 the the DT cord-267475-6f4h3cck 996 66 fidelity fidelity NN cord-267475-6f4h3cck 996 67 of of IN cord-267475-6f4h3cck 996 68 initiation initiation NN cord-267475-6f4h3cck 996 69 of of IN cord-267475-6f4h3cck 996 70 translation translation NN cord-267475-6f4h3cck 996 71 in in IN cord-267475-6f4h3cck 996 72 reticulocyte reticulocyte NNP cord-267475-6f4h3cck 996 73 lysates lysate NNS cord-267475-6f4h3cck 996 74 from from IN cord-267475-6f4h3cck 996 75 commercial commercial JJ cord-267475-6f4h3cck 996 76 sources source NNS cord-267475-6f4h3cck 997 1 An an DT cord-267475-6f4h3cck 997 2 analysis analysis NN cord-267475-6f4h3cck 997 3 of of IN cord-267475-6f4h3cck 997 4 vertebrate vertebrate JJ cord-267475-6f4h3cck 997 5 mRNA mRNA NNP cord-267475-6f4h3cck 997 6 sequences sequence NNS cord-267475-6f4h3cck 997 7 : : : cord-267475-6f4h3cck 997 8 intimations intimation NNS cord-267475-6f4h3cck 997 9 of of IN cord-267475-6f4h3cck 997 10 translational translational JJ cord-267475-6f4h3cck 997 11 control control NN cord-267475-6f4h3cck 997 12 Structural structural JJ cord-267475-6f4h3cck 997 13 features feature NNS cord-267475-6f4h3cck 997 14 in in IN cord-267475-6f4h3cck 997 15 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 997 16 mRNAs mRNAs NNPS cord-267475-6f4h3cck 997 17 that that WDT cord-267475-6f4h3cck 997 18 modulate modulate VBP cord-267475-6f4h3cck 997 19 the the DT cord-267475-6f4h3cck 997 20 initiation initiation NN cord-267475-6f4h3cck 997 21 of of IN cord-267475-6f4h3cck 997 22 translation translation NN cord-267475-6f4h3cck 998 1 A a DT cord-267475-6f4h3cck 998 2 short short JJ cord-267475-6f4h3cck 998 3 leader leader NN cord-267475-6f4h3cck 998 4 sequence sequence NN cord-267475-6f4h3cck 998 5 impairs impair VBZ cord-267475-6f4h3cck 998 6 the the DT cord-267475-6f4h3cck 998 7 fidelity fidelity NN cord-267475-6f4h3cck 998 8 of of IN cord-267475-6f4h3cck 998 9 initiation initiation NN cord-267475-6f4h3cck 998 10 by by IN cord-267475-6f4h3cck 998 11 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 998 12 ribosomes ribosome NNS cord-267475-6f4h3cck 998 13 Adherence adherence NN cord-267475-6f4h3cck 998 14 to to IN cord-267475-6f4h3cck 998 15 the the DT cord-267475-6f4h3cck 998 16 first first JJ cord-267475-6f4h3cck 998 17 - - HYPH cord-267475-6f4h3cck 998 18 AUG aug NN cord-267475-6f4h3cck 998 19 rule rule NN cord-267475-6f4h3cck 998 20 when when WRB cord-267475-6f4h3cck 998 21 a a DT cord-267475-6f4h3cck 998 22 second second JJ cord-267475-6f4h3cck 998 23 AUG AUG NNP cord-267475-6f4h3cck 998 24 codon codon NN cord-267475-6f4h3cck 998 25 follows follow VBZ cord-267475-6f4h3cck 998 26 closely closely RB cord-267475-6f4h3cck 998 27 upon upon IN cord-267475-6f4h3cck 998 28 the the DT cord-267475-6f4h3cck 998 29 first first JJ cord-267475-6f4h3cck 998 30 Interpreting interpret VBG cord-267475-6f4h3cck 998 31 cDNA cdna NN cord-267475-6f4h3cck 998 32 sequences sequence NNS cord-267475-6f4h3cck 998 33 : : : cord-267475-6f4h3cck 998 34 some some DT cord-267475-6f4h3cck 998 35 insights insight NNS cord-267475-6f4h3cck 998 36 from from IN cord-267475-6f4h3cck 998 37 studies study NNS cord-267475-6f4h3cck 998 38 on on IN cord-267475-6f4h3cck 998 39 translation translation NN cord-267475-6f4h3cck 998 40 Recognition Recognition NNP cord-267475-6f4h3cck 998 41 of of IN cord-267475-6f4h3cck 998 42 AUG AUG NNP cord-267475-6f4h3cck 998 43 and and CC cord-267475-6f4h3cck 998 44 alternative alternative JJ cord-267475-6f4h3cck 998 45 initiator initiator NN cord-267475-6f4h3cck 998 46 codons codon NNS cord-267475-6f4h3cck 998 47 is be VBZ cord-267475-6f4h3cck 998 48 augmented augment VBN cord-267475-6f4h3cck 998 49 by by IN cord-267475-6f4h3cck 998 50 G g NN cord-267475-6f4h3cck 998 51 in in IN cord-267475-6f4h3cck 998 52 position position NN cord-267475-6f4h3cck 998 53 þ þ NNP cord-267475-6f4h3cck 998 54 4 4 CD cord-267475-6f4h3cck 998 55 but but CC cord-267475-6f4h3cck 998 56 is be VBZ cord-267475-6f4h3cck 998 57 not not RB cord-267475-6f4h3cck 998 58 generally generally RB cord-267475-6f4h3cck 998 59 affected affect VBN cord-267475-6f4h3cck 998 60 by by IN cord-267475-6f4h3cck 998 61 the the DT cord-267475-6f4h3cck 998 62 nucleotides nucleotide NNS cord-267475-6f4h3cck 998 63 in in IN cord-267475-6f4h3cck 998 64 positions position NNS cord-267475-6f4h3cck 998 65 þ5 þ5 NNP cord-267475-6f4h3cck 998 66 and and CC cord-267475-6f4h3cck 998 67 þ6 þ6 NNP cord-267475-6f4h3cck 998 68 Primer primer NN cord-267475-6f4h3cck 998 69 - - HYPH cord-267475-6f4h3cck 998 70 extension extension NN cord-267475-6f4h3cck 998 71 analysis analysis NN cord-267475-6f4h3cck 998 72 of of IN cord-267475-6f4h3cck 998 73 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 998 74 ribosome ribosome NN cord-267475-6f4h3cck 998 75 - - HYPH cord-267475-6f4h3cck 998 76 mRNA mrna NN cord-267475-6f4h3cck 998 77 complexes complex NNS cord-267475-6f4h3cck 998 78 Initiation Initiation NNP cord-267475-6f4h3cck 998 79 of of IN cord-267475-6f4h3cck 998 80 translation translation NN cord-267475-6f4h3cck 998 81 in in IN cord-267475-6f4h3cck 998 82 prokaryotes prokaryote NNS cord-267475-6f4h3cck 998 83 and and CC cord-267475-6f4h3cck 998 84 eukaryotes eukaryote NNS cord-267475-6f4h3cck 999 1 Do do VB cord-267475-6f4h3cck 999 2 the the DT cord-267475-6f4h3cck 999 3 5 5 CD cord-267475-6f4h3cck 999 4 0 0 CD cord-267475-6f4h3cck 999 5 untranslated untranslated JJ cord-267475-6f4h3cck 999 6 domains domain NNS cord-267475-6f4h3cck 999 7 of of IN cord-267475-6f4h3cck 999 8 human human JJ cord-267475-6f4h3cck 999 9 cDNAs cdna NNS cord-267475-6f4h3cck 999 10 challenge challenge VBP cord-267475-6f4h3cck 999 11 the the DT cord-267475-6f4h3cck 999 12 rules rule NNS cord-267475-6f4h3cck 999 13 for for IN cord-267475-6f4h3cck 999 14 initiation initiation NN cord-267475-6f4h3cck 999 15 of of IN cord-267475-6f4h3cck 999 16 translation translation NN cord-267475-6f4h3cck 999 17 ( ( -LRB- cord-267475-6f4h3cck 999 18 or or CC cord-267475-6f4h3cck 999 19 is be VBZ cord-267475-6f4h3cck 999 20 it -PRON- PRP cord-267475-6f4h3cck 999 21 vice vice RB cord-267475-6f4h3cck 999 22 versa versa RB cord-267475-6f4h3cck 999 23 New new JJ cord-267475-6f4h3cck 999 24 ways way NNS cord-267475-6f4h3cck 999 25 of of IN cord-267475-6f4h3cck 999 26 initiating initiate VBG cord-267475-6f4h3cck 999 27 translation translation NN cord-267475-6f4h3cck 999 28 in in IN cord-267475-6f4h3cck 999 29 eukaryotes eukaryote NNS cord-267475-6f4h3cck 999 30 ? ? . cord-267475-6f4h3cck 1000 1 Constraints constraint NNS cord-267475-6f4h3cck 1000 2 on on IN cord-267475-6f4h3cck 1000 3 reinitiation reinitiation NN cord-267475-6f4h3cck 1000 4 of of IN cord-267475-6f4h3cck 1000 5 translation translation NN cord-267475-6f4h3cck 1000 6 in in IN cord-267475-6f4h3cck 1000 7 mammals mammal NNS cord-267475-6f4h3cck 1000 8 Emerging emerge VBG cord-267475-6f4h3cck 1000 9 links link NNS cord-267475-6f4h3cck 1000 10 between between IN cord-267475-6f4h3cck 1000 11 initiation initiation NN cord-267475-6f4h3cck 1000 12 of of IN cord-267475-6f4h3cck 1000 13 translation translation NN cord-267475-6f4h3cck 1000 14 and and CC cord-267475-6f4h3cck 1000 15 human human JJ cord-267475-6f4h3cck 1000 16 diseases disease NNS cord-267475-6f4h3cck 1000 17 Migration migration NN cord-267475-6f4h3cck 1000 18 of of IN cord-267475-6f4h3cck 1000 19 40S 40s CD cord-267475-6f4h3cck 1000 20 ribosomal ribosomal JJ cord-267475-6f4h3cck 1000 21 subunits subunit NNS cord-267475-6f4h3cck 1000 22 on on IN cord-267475-6f4h3cck 1000 23 messenger messenger NN cord-267475-6f4h3cck 1000 24 RNA RNA NNP cord-267475-6f4h3cck 1000 25 in in IN cord-267475-6f4h3cck 1000 26 the the DT cord-267475-6f4h3cck 1000 27 presence presence NN cord-267475-6f4h3cck 1000 28 of of IN cord-267475-6f4h3cck 1000 29 edeine edeine NN cord-267475-6f4h3cck 1000 30 Significant significant JJ cord-267475-6f4h3cck 1000 31 impact impact NN cord-267475-6f4h3cck 1000 32 of of IN cord-267475-6f4h3cck 1000 33 the the DT cord-267475-6f4h3cck 1000 34 þ þ NNP cord-267475-6f4h3cck 1000 35 93 93 CD cord-267475-6f4h3cck 1000 36 C C NNP cord-267475-6f4h3cck 1000 37 / / SYM cord-267475-6f4h3cck 1000 38 T t NN cord-267475-6f4h3cck 1000 39 polymorphism polymorphism NN cord-267475-6f4h3cck 1000 40 in in IN cord-267475-6f4h3cck 1000 41 the the DT cord-267475-6f4h3cck 1000 42 apolipoprotein(a apolipoprotein(a NNP cord-267475-6f4h3cck 1000 43 ) ) -RRB- cord-267475-6f4h3cck 1000 44 gene gene NN cord-267475-6f4h3cck 1000 45 on on IN cord-267475-6f4h3cck 1000 46 Lp(a Lp(a NNP cord-267475-6f4h3cck 1000 47 ) ) -RRB- cord-267475-6f4h3cck 1000 48 concentrations concentration NNS cord-267475-6f4h3cck 1000 49 in in IN cord-267475-6f4h3cck 1000 50 Africans Africans NNPS cord-267475-6f4h3cck 1000 51 but but CC cord-267475-6f4h3cck 1000 52 not not RB cord-267475-6f4h3cck 1000 53 in in IN cord-267475-6f4h3cck 1000 54 Caucasians Caucasians NNPS cord-267475-6f4h3cck 1000 55 : : : cord-267475-6f4h3cck 1000 56 confounding confound VBG cord-267475-6f4h3cck 1000 57 effect effect NN cord-267475-6f4h3cck 1000 58 of of IN cord-267475-6f4h3cck 1000 59 linkage linkage NN cord-267475-6f4h3cck 1000 60 disequilibrium disequilibrium NN cord-267475-6f4h3cck 1000 61 Identification identification NN cord-267475-6f4h3cck 1000 62 of of IN cord-267475-6f4h3cck 1000 63 the the DT cord-267475-6f4h3cck 1000 64 translational translational JJ cord-267475-6f4h3cck 1000 65 initiation initiation NN cord-267475-6f4h3cck 1000 66 codon codon NN cord-267475-6f4h3cck 1000 67 in in IN cord-267475-6f4h3cck 1000 68 human human JJ cord-267475-6f4h3cck 1000 69 MAGED1 MAGED1 . cord-267475-6f4h3cck 1000 70 Genomic Genomic NNP cord-267475-6f4h3cck 1000 71 organization organization NN cord-267475-6f4h3cck 1000 72 and and CC cord-267475-6f4h3cck 1000 73 biosynthesis biosynthesis NN cord-267475-6f4h3cck 1000 74 of of IN cord-267475-6f4h3cck 1000 75 secreted secrete VBN cord-267475-6f4h3cck 1000 76 and and CC cord-267475-6f4h3cck 1000 77 cytoplasmic cytoplasmic JJ cord-267475-6f4h3cck 1000 78 forms form NNS cord-267475-6f4h3cck 1000 79 of of IN cord-267475-6f4h3cck 1000 80 gelsolin gelsolin NNP cord-267475-6f4h3cck 1000 81 Archaeal Archaeal NNP cord-267475-6f4h3cck 1000 82 translation translation NN cord-267475-6f4h3cck 1000 83 initiation initiation NN cord-267475-6f4h3cck 1000 84 revisited revisit VBD cord-267475-6f4h3cck 1000 85 : : : cord-267475-6f4h3cck 1000 86 the the DT cord-267475-6f4h3cck 1000 87 initiation initiation NN cord-267475-6f4h3cck 1000 88 factor factor NN cord-267475-6f4h3cck 1000 89 2 2 CD cord-267475-6f4h3cck 1000 90 and and CC cord-267475-6f4h3cck 1000 91 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 1000 92 initiation initiation NN cord-267475-6f4h3cck 1000 93 factor factor NN cord-267475-6f4h3cck 1000 94 2B 2b CD cord-267475-6f4h3cck 1000 95 ab ab NNP cord-267475-6f4h3cck 1000 96 - - HYPH cord-267475-6f4h3cck 1000 97 d d NNP cord-267475-6f4h3cck 1000 98 subunit subunit NN cord-267475-6f4h3cck 1000 99 families family NNS cord-267475-6f4h3cck 1001 1 The the DT cord-267475-6f4h3cck 1001 2 molecular molecular JJ cord-267475-6f4h3cck 1001 3 biology biology NN cord-267475-6f4h3cck 1001 4 of of IN cord-267475-6f4h3cck 1001 5 coronaviruses coronaviruse NNS cord-267475-6f4h3cck 1002 1 A a DT cord-267475-6f4h3cck 1002 2 transcriptional transcriptional JJ cord-267475-6f4h3cck 1002 3 repressor repressor NN cord-267475-6f4h3cck 1002 4 encoded encode VBN cord-267475-6f4h3cck 1002 5 by by IN cord-267475-6f4h3cck 1002 6 BPV-1 BPV-1 NNP cord-267475-6f4h3cck 1002 7 shares share VBZ cord-267475-6f4h3cck 1002 8 a a DT cord-267475-6f4h3cck 1002 9 common common JJ cord-267475-6f4h3cck 1002 10 carboxy carboxy JJ cord-267475-6f4h3cck 1002 11 - - HYPH cord-267475-6f4h3cck 1002 12 terminal terminal NN cord-267475-6f4h3cck 1002 13 domain domain NN cord-267475-6f4h3cck 1002 14 with with IN cord-267475-6f4h3cck 1002 15 the the DT cord-267475-6f4h3cck 1002 16 E2 E2 NNP cord-267475-6f4h3cck 1002 17 transactivator transactivator NNP cord-267475-6f4h3cck 1003 1 The the DT cord-267475-6f4h3cck 1003 2 genetics genetic NNS cord-267475-6f4h3cck 1003 3 of of IN cord-267475-6f4h3cck 1003 4 bovine bovine JJ cord-267475-6f4h3cck 1003 5 papillomavirus papillomavirus NN cord-267475-6f4h3cck 1003 6 type type NN cord-267475-6f4h3cck 1003 7 1 1 CD cord-267475-6f4h3cck 1003 8 Targeting targeting NN cord-267475-6f4h3cck 1003 9 of of IN cord-267475-6f4h3cck 1003 10 a a DT cord-267475-6f4h3cck 1003 11 human human JJ cord-267475-6f4h3cck 1003 12 iron iron NN cord-267475-6f4h3cck 1003 13 - - HYPH cord-267475-6f4h3cck 1003 14 sulfur sulfur NN cord-267475-6f4h3cck 1003 15 cluster cluster NN cord-267475-6f4h3cck 1003 16 assembly assembly NN cord-267475-6f4h3cck 1003 17 enzyme enzyme NN cord-267475-6f4h3cck 1003 18 , , , cord-267475-6f4h3cck 1003 19 nifs nifs NNP cord-267475-6f4h3cck 1003 20 , , , cord-267475-6f4h3cck 1003 21 to to IN cord-267475-6f4h3cck 1003 22 different different JJ cord-267475-6f4h3cck 1003 23 subcellular subcellular JJ cord-267475-6f4h3cck 1003 24 compartments compartment NNS cord-267475-6f4h3cck 1003 25 is be VBZ cord-267475-6f4h3cck 1003 26 regulated regulate VBN cord-267475-6f4h3cck 1003 27 through through IN cord-267475-6f4h3cck 1003 28 alternative alternative JJ cord-267475-6f4h3cck 1003 29 AUG AUG NNP cord-267475-6f4h3cck 1003 30 utilization utilization NN cord-267475-6f4h3cck 1003 31 Translational translational JJ cord-267475-6f4h3cck 1003 32 enhancement enhancement NN cord-267475-6f4h3cck 1003 33 of of IN cord-267475-6f4h3cck 1003 34 mdm2 mdm2 JJ cord-267475-6f4h3cck 1003 35 oncogene oncogene NN cord-267475-6f4h3cck 1003 36 expression expression NN cord-267475-6f4h3cck 1003 37 in in IN cord-267475-6f4h3cck 1003 38 human human JJ cord-267475-6f4h3cck 1003 39 tumor tumor NN cord-267475-6f4h3cck 1003 40 cells cell NNS cord-267475-6f4h3cck 1003 41 containing contain VBG cord-267475-6f4h3cck 1003 42 a a DT cord-267475-6f4h3cck 1003 43 stabilized stabilize VBN cord-267475-6f4h3cck 1003 44 wild wild JJ cord-267475-6f4h3cck 1003 45 - - HYPH cord-267475-6f4h3cck 1003 46 type type NN cord-267475-6f4h3cck 1003 47 p53 p53 NN cord-267475-6f4h3cck 1003 48 protein protein NN cord-267475-6f4h3cck 1003 49 Nucleotide nucleotide JJ cord-267475-6f4h3cck 1003 50 sequence sequence NN cord-267475-6f4h3cck 1003 51 of of IN cord-267475-6f4h3cck 1003 52 the the DT cord-267475-6f4h3cck 1003 53 gag gag NN cord-267475-6f4h3cck 1003 54 gene gene NN cord-267475-6f4h3cck 1003 55 and and CC cord-267475-6f4h3cck 1003 56 gag gag NN cord-267475-6f4h3cck 1003 57 - - HYPH cord-267475-6f4h3cck 1003 58 pol pol NN cord-267475-6f4h3cck 1003 59 junction junction NN cord-267475-6f4h3cck 1003 60 of of IN cord-267475-6f4h3cck 1003 61 feline feline JJ cord-267475-6f4h3cck 1003 62 leukemia leukemia NN cord-267475-6f4h3cck 1003 63 virus virus NN cord-267475-6f4h3cck 1003 64 Genomic Genomic NNP cord-267475-6f4h3cck 1003 65 organization organization NN cord-267475-6f4h3cck 1003 66 of of IN cord-267475-6f4h3cck 1003 67 the the DT cord-267475-6f4h3cck 1003 68 mouse mouse NN cord-267475-6f4h3cck 1003 69 peroxisome peroxisome NN cord-267475-6f4h3cck 1003 70 proliferator proliferator NN cord-267475-6f4h3cck 1003 71 activated activate VBN cord-267475-6f4h3cck 1003 72 receptor receptor NN cord-267475-6f4h3cck 1003 73 b b NNP cord-267475-6f4h3cck 1003 74 / / SYM cord-267475-6f4h3cck 1003 75 g g NN cord-267475-6f4h3cck 1003 76 gene gene NN cord-267475-6f4h3cck 1003 77 . . . cord-267475-6f4h3cck 1004 1 Alternative alternative JJ cord-267475-6f4h3cck 1004 2 promoter promoter NN cord-267475-6f4h3cck 1004 3 usage usage NN cord-267475-6f4h3cck 1004 4 and and CC cord-267475-6f4h3cck 1004 5 splicing splicing NN cord-267475-6f4h3cck 1004 6 yield yield NN cord-267475-6f4h3cck 1004 7 transcripts transcript NNS cord-267475-6f4h3cck 1004 8 exhibiting exhibit VBG cord-267475-6f4h3cck 1004 9 differential differential JJ cord-267475-6f4h3cck 1004 10 translational translational JJ cord-267475-6f4h3cck 1004 11 efficiency efficiency NN cord-267475-6f4h3cck 1005 1 The the DT cord-267475-6f4h3cck 1005 2 hormone hormone NN cord-267475-6f4h3cck 1005 3 - - HYPH cord-267475-6f4h3cck 1005 4 sensitive sensitive JJ cord-267475-6f4h3cck 1005 5 lipase lipase NN cord-267475-6f4h3cck 1005 6 gene gene NN cord-267475-6f4h3cck 1005 7 is be VBZ cord-267475-6f4h3cck 1005 8 transcribed transcribe VBN cord-267475-6f4h3cck 1005 9 from from IN cord-267475-6f4h3cck 1005 10 at at RB cord-267475-6f4h3cck 1005 11 least least RBS cord-267475-6f4h3cck 1005 12 five five CD cord-267475-6f4h3cck 1005 13 alternative alternative JJ cord-267475-6f4h3cck 1005 14 first first JJ cord-267475-6f4h3cck 1005 15 exons exon NNS cord-267475-6f4h3cck 1005 16 in in IN cord-267475-6f4h3cck 1005 17 mouse mouse NN cord-267475-6f4h3cck 1005 18 adipose adipose JJ cord-267475-6f4h3cck 1005 19 tissue tissue NN cord-267475-6f4h3cck 1005 20 Polyamine polyamine JJ cord-267475-6f4h3cck 1005 21 regulation regulation NN cord-267475-6f4h3cck 1005 22 of of IN cord-267475-6f4h3cck 1005 23 ribosome ribosome NN cord-267475-6f4h3cck 1005 24 pausing pause VBG cord-267475-6f4h3cck 1005 25 at at IN cord-267475-6f4h3cck 1005 26 the the DT cord-267475-6f4h3cck 1005 27 upstream upstream JJ cord-267475-6f4h3cck 1005 28 open open JJ cord-267475-6f4h3cck 1005 29 reading reading NN cord-267475-6f4h3cck 1005 30 frame frame NN cord-267475-6f4h3cck 1005 31 of of IN cord-267475-6f4h3cck 1005 32 Sadenosylmethionine Sadenosylmethionine NNP cord-267475-6f4h3cck 1005 33 decarboxylase decarboxylase NN cord-267475-6f4h3cck 1005 34 Mutation Mutation NNP cord-267475-6f4h3cck 1005 35 eliminating eliminate VBG cord-267475-6f4h3cck 1005 36 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 1005 37 leader leader NN cord-267475-6f4h3cck 1005 38 sequence sequence NN cord-267475-6f4h3cck 1005 39 of of IN cord-267475-6f4h3cck 1005 40 methylmalonyl methylmalonyl NNP cord-267475-6f4h3cck 1005 41 - - HYPH cord-267475-6f4h3cck 1005 42 CoA CoA NNP cord-267475-6f4h3cck 1005 43 mutase mutase NN cord-267475-6f4h3cck 1005 44 causes cause VBZ cord-267475-6f4h3cck 1005 45 mut mut NNP cord-267475-6f4h3cck 1005 46 o o NNP cord-267475-6f4h3cck 1005 47 methylmalonic methylmalonic NNP cord-267475-6f4h3cck 1005 48 acidemia acidemia NN cord-267475-6f4h3cck 1006 1 Molecular molecular JJ cord-267475-6f4h3cck 1006 2 cloning cloning NN cord-267475-6f4h3cck 1006 3 and and CC cord-267475-6f4h3cck 1006 4 characterization characterization NN cord-267475-6f4h3cck 1006 5 of of IN cord-267475-6f4h3cck 1006 6 the the DT cord-267475-6f4h3cck 1006 7 mouse mouse NN cord-267475-6f4h3cck 1006 8 peroxiredoxin peroxiredoxin NNP cord-267475-6f4h3cck 1006 9 V V NNP cord-267475-6f4h3cck 1006 10 gene gene NN cord-267475-6f4h3cck 1007 1 The the DT cord-267475-6f4h3cck 1007 2 5 5 CD cord-267475-6f4h3cck 1007 3 0 0 CD cord-267475-6f4h3cck 1007 4 untranslated untranslated JJ cord-267475-6f4h3cck 1007 5 regions region NNS cord-267475-6f4h3cck 1007 6 of of IN cord-267475-6f4h3cck 1007 7 the the DT cord-267475-6f4h3cck 1007 8 rat rat NN cord-267475-6f4h3cck 1007 9 A A NNP cord-267475-6f4h3cck 1007 10 2A 2a CD cord-267475-6f4h3cck 1007 11 adenosine adenosine NN cord-267475-6f4h3cck 1007 12 receptor receptor NN cord-267475-6f4h3cck 1007 13 gene gene NN cord-267475-6f4h3cck 1007 14 function function NN cord-267475-6f4h3cck 1007 15 as as IN cord-267475-6f4h3cck 1007 16 negative negative JJ cord-267475-6f4h3cck 1007 17 translational translational JJ cord-267475-6f4h3cck 1007 18 regulators regulator NNS cord-267475-6f4h3cck 1007 19 Zebrafish Zebrafish NNP cord-267475-6f4h3cck 1007 20 wnt8 wnt8 WP cord-267475-6f4h3cck 1007 21 encodes encode VBZ cord-267475-6f4h3cck 1007 22 two two CD cord-267475-6f4h3cck 1007 23 Wnt8 Wnt8 NNP cord-267475-6f4h3cck 1007 24 proteins protein NNS cord-267475-6f4h3cck 1007 25 on on IN cord-267475-6f4h3cck 1007 26 a a DT cord-267475-6f4h3cck 1007 27 bicistronic bicistronic JJ cord-267475-6f4h3cck 1007 28 transcript transcript NN cord-267475-6f4h3cck 1007 29 and and CC cord-267475-6f4h3cck 1007 30 is be VBZ cord-267475-6f4h3cck 1007 31 required require VBN cord-267475-6f4h3cck 1007 32 for for IN cord-267475-6f4h3cck 1007 33 mesoderm mesoderm NNS cord-267475-6f4h3cck 1007 34 and and CC cord-267475-6f4h3cck 1007 35 neurectoderm neurectoderm NNP cord-267475-6f4h3cck 1007 36 patterning pattern VBG cord-267475-6f4h3cck 1007 37 The the DT cord-267475-6f4h3cck 1007 38 human human JJ cord-267475-6f4h3cck 1007 39 galactose-1-phosphate galactose-1-phosphate NNP cord-267475-6f4h3cck 1007 40 uridyltransferase uridyltransferase NN cord-267475-6f4h3cck 1007 41 gene gene NN cord-267475-6f4h3cck 1007 42 Translational translational JJ cord-267475-6f4h3cck 1007 43 control control NN cord-267475-6f4h3cck 1007 44 of of IN cord-267475-6f4h3cck 1007 45 cell cell NN cord-267475-6f4h3cck 1007 46 fate fate NN cord-267475-6f4h3cck 1007 47 : : : cord-267475-6f4h3cck 1008 1 availability availability NN cord-267475-6f4h3cck 1008 2 of of IN cord-267475-6f4h3cck 1008 3 phosphorylation phosphorylation NN cord-267475-6f4h3cck 1008 4 sites site NNS cord-267475-6f4h3cck 1008 5 on on IN cord-267475-6f4h3cck 1008 6 translational translational JJ cord-267475-6f4h3cck 1008 7 repressor repressor NN cord-267475-6f4h3cck 1008 8 4E 4E NNP cord-267475-6f4h3cck 1008 9 - - HYPH cord-267475-6f4h3cck 1008 10 BP1 BP1 NNP cord-267475-6f4h3cck 1008 11 governs govern VBZ cord-267475-6f4h3cck 1008 12 its -PRON- PRP$ cord-267475-6f4h3cck 1008 13 proapoptotic proapoptotic JJ cord-267475-6f4h3cck 1008 14 potency potency NN cord-267475-6f4h3cck 1009 1 Cell cell NN cord-267475-6f4h3cck 1009 2 - - HYPH cord-267475-6f4h3cck 1009 3 to to IN cord-267475-6f4h3cck 1009 4 - - HYPH cord-267475-6f4h3cck 1009 5 cell cell NN cord-267475-6f4h3cck 1009 6 movement movement NN cord-267475-6f4h3cck 1009 7 of of IN cord-267475-6f4h3cck 1009 8 turnip turnip NN cord-267475-6f4h3cck 1009 9 crinkle crinkle NN cord-267475-6f4h3cck 1009 10 virus virus NN cord-267475-6f4h3cck 1009 11 is be VBZ cord-267475-6f4h3cck 1009 12 controlled control VBN cord-267475-6f4h3cck 1009 13 by by IN cord-267475-6f4h3cck 1009 14 two two CD cord-267475-6f4h3cck 1009 15 small small JJ cord-267475-6f4h3cck 1009 16 open open JJ cord-267475-6f4h3cck 1009 17 reading reading NN cord-267475-6f4h3cck 1009 18 frames frame NNS cord-267475-6f4h3cck 1009 19 that that WDT cord-267475-6f4h3cck 1009 20 function function VBP cord-267475-6f4h3cck 1009 21 in in IN cord-267475-6f4h3cck 1009 22 trans trans NNP cord-267475-6f4h3cck 1010 1 A a DT cord-267475-6f4h3cck 1010 2 translationally translationally RB cord-267475-6f4h3cck 1010 3 regulated regulate VBN cord-267475-6f4h3cck 1010 4 Tousled tousled JJ cord-267475-6f4h3cck 1010 5 kinase kinase NN cord-267475-6f4h3cck 1010 6 phosphorylates phosphorylate VBZ cord-267475-6f4h3cck 1010 7 histone histone NN cord-267475-6f4h3cck 1010 8 H3 H3 NNP cord-267475-6f4h3cck 1010 9 and and CC cord-267475-6f4h3cck 1010 10 confers confer VBZ cord-267475-6f4h3cck 1010 11 radioresistance radioresistance NN cord-267475-6f4h3cck 1010 12 when when WRB cord-267475-6f4h3cck 1010 13 overexpressed overexpresse VBN cord-267475-6f4h3cck 1010 14 A a DT cord-267475-6f4h3cck 1010 15 30-kDa 30-kda CD cord-267475-6f4h3cck 1010 16 alternative alternative JJ cord-267475-6f4h3cck 1010 17 translation translation NN cord-267475-6f4h3cck 1010 18 product product NN cord-267475-6f4h3cck 1010 19 of of IN cord-267475-6f4h3cck 1010 20 the the DT cord-267475-6f4h3cck 1010 21 CCAAT CCAAT NNP cord-267475-6f4h3cck 1010 22 / / SYM cord-267475-6f4h3cck 1010 23 enhancer enhancer NN cord-267475-6f4h3cck 1010 24 binding bind VBG cord-267475-6f4h3cck 1010 25 protein protein NN cord-267475-6f4h3cck 1010 26 a a DT cord-267475-6f4h3cck 1010 27 message message NN cord-267475-6f4h3cck 1010 28 : : : cord-267475-6f4h3cck 1011 1 transcriptional transcriptional JJ cord-267475-6f4h3cck 1011 2 activator activator NN cord-267475-6f4h3cck 1011 3 lacking lack VBG cord-267475-6f4h3cck 1011 4 antimitotic antimitotic JJ cord-267475-6f4h3cck 1011 5 activity activity NN cord-267475-6f4h3cck 1011 6 Intron intron NN cord-267475-6f4h3cck 1011 7 - - HYPH cord-267475-6f4h3cck 1011 8 exon exon NN cord-267475-6f4h3cck 1011 9 structure structure NN cord-267475-6f4h3cck 1011 10 of of IN cord-267475-6f4h3cck 1011 11 the the DT cord-267475-6f4h3cck 1011 12 MET MET NNP cord-267475-6f4h3cck 1011 13 gene gene NN cord-267475-6f4h3cck 1011 14 and and CC cord-267475-6f4h3cck 1011 15 cloning cloning NN cord-267475-6f4h3cck 1011 16 of of IN cord-267475-6f4h3cck 1011 17 an an DT cord-267475-6f4h3cck 1011 18 alternatively alternatively RB cord-267475-6f4h3cck 1011 19 - - HYPH cord-267475-6f4h3cck 1011 20 spliced splice VBN cord-267475-6f4h3cck 1011 21 Met Met NNP cord-267475-6f4h3cck 1011 22 isoform isoform NN cord-267475-6f4h3cck 1011 23 reveals reveal VBZ cord-267475-6f4h3cck 1011 24 frequent frequent JJ cord-267475-6f4h3cck 1011 25 exon exon NN cord-267475-6f4h3cck 1011 26 - - HYPH cord-267475-6f4h3cck 1011 27 skipping skipping NN cord-267475-6f4h3cck 1011 28 of of IN cord-267475-6f4h3cck 1011 29 a a DT cord-267475-6f4h3cck 1011 30 single single JJ cord-267475-6f4h3cck 1011 31 large large JJ cord-267475-6f4h3cck 1011 32 internal internal JJ cord-267475-6f4h3cck 1011 33 exon exon NN cord-267475-6f4h3cck 1012 1 An an DT cord-267475-6f4h3cck 1012 2 extended extended JJ cord-267475-6f4h3cck 1012 3 RNA RNA NNP cord-267475-6f4h3cck 1012 4 / / SYM cord-267475-6f4h3cck 1012 5 RNA RNA NNP cord-267475-6f4h3cck 1012 6 duplex duplex NN cord-267475-6f4h3cck 1012 7 structure structure NN cord-267475-6f4h3cck 1012 8 within within IN cord-267475-6f4h3cck 1012 9 the the DT cord-267475-6f4h3cck 1012 10 coding code VBG cord-267475-6f4h3cck 1012 11 region region NN cord-267475-6f4h3cck 1012 12 of of IN cord-267475-6f4h3cck 1012 13 mRNA mRNA NNP cord-267475-6f4h3cck 1012 14 does do VBZ cord-267475-6f4h3cck 1012 15 not not RB cord-267475-6f4h3cck 1012 16 block block VB cord-267475-6f4h3cck 1012 17 translational translational JJ cord-267475-6f4h3cck 1012 18 elongation elongation NN cord-267475-6f4h3cck 1012 19 Characterization characterization NN cord-267475-6f4h3cck 1012 20 of of IN cord-267475-6f4h3cck 1012 21 the the DT cord-267475-6f4h3cck 1012 22 5 5 CD cord-267475-6f4h3cck 1012 23 0 0 CD cord-267475-6f4h3cck 1012 24 untranslated untranslated JJ cord-267475-6f4h3cck 1012 25 region region NN cord-267475-6f4h3cck 1012 26 of of IN cord-267475-6f4h3cck 1012 27 the the DT cord-267475-6f4h3cck 1012 28 human human NNP cord-267475-6f4h3cck 1012 29 c c NNP cord-267475-6f4h3cck 1012 30 - - HYPH cord-267475-6f4h3cck 1012 31 fgr fgr NNP cord-267475-6f4h3cck 1012 32 gene gene NN cord-267475-6f4h3cck 1012 33 and and CC cord-267475-6f4h3cck 1012 34 identification identification NN cord-267475-6f4h3cck 1012 35 of of IN cord-267475-6f4h3cck 1012 36 the the DT cord-267475-6f4h3cck 1012 37 major major JJ cord-267475-6f4h3cck 1012 38 myelomonocytic myelomonocytic NNP cord-267475-6f4h3cck 1012 39 c c NNP cord-267475-6f4h3cck 1012 40 - - HYPH cord-267475-6f4h3cck 1012 41 fgr fgr NNP cord-267475-6f4h3cck 1012 42 promoter promoter NN cord-267475-6f4h3cck 1012 43 The the DT cord-267475-6f4h3cck 1012 44 promoter promoter NN cord-267475-6f4h3cck 1012 45 , , , cord-267475-6f4h3cck 1012 46 transcriptional transcriptional JJ cord-267475-6f4h3cck 1012 47 unit unit NN cord-267475-6f4h3cck 1012 48 , , , cord-267475-6f4h3cck 1012 49 and and CC cord-267475-6f4h3cck 1012 50 coding code VBG cord-267475-6f4h3cck 1012 51 sequence sequence NN cord-267475-6f4h3cck 1012 52 of of IN cord-267475-6f4h3cck 1012 53 herpes herpes NNP cord-267475-6f4h3cck 1012 54 simplex simplex NNP cord-267475-6f4h3cck 1012 55 virus virus NN cord-267475-6f4h3cck 1012 56 1 1 CD cord-267475-6f4h3cck 1012 57 family family NN cord-267475-6f4h3cck 1012 58 35 35 CD cord-267475-6f4h3cck 1012 59 proteins protein NNS cord-267475-6f4h3cck 1012 60 are be VBP cord-267475-6f4h3cck 1012 61 contained contain VBN cord-267475-6f4h3cck 1012 62 within within IN cord-267475-6f4h3cck 1012 63 and and CC cord-267475-6f4h3cck 1012 64 in in IN cord-267475-6f4h3cck 1012 65 frame frame NN cord-267475-6f4h3cck 1012 66 with with IN cord-267475-6f4h3cck 1012 67 the the DT cord-267475-6f4h3cck 1012 68 U U NNP cord-267475-6f4h3cck 1012 69 L L NNP cord-267475-6f4h3cck 1012 70 26 26 CD cord-267475-6f4h3cck 1012 71 open open JJ cord-267475-6f4h3cck 1012 72 reading reading NN cord-267475-6f4h3cck 1012 73 frame frame NN cord-267475-6f4h3cck 1012 74 Initiation initiation NN cord-267475-6f4h3cck 1012 75 of of IN cord-267475-6f4h3cck 1012 76 translation translation NN cord-267475-6f4h3cck 1012 77 from from IN cord-267475-6f4h3cck 1012 78 a a DT cord-267475-6f4h3cck 1012 79 downstream downstream NN cord-267475-6f4h3cck 1012 80 in in IN cord-267475-6f4h3cck 1012 81 - - HYPH cord-267475-6f4h3cck 1012 82 frame frame NN cord-267475-6f4h3cck 1012 83 AUG AUG NNP cord-267475-6f4h3cck 1012 84 codon codon NN cord-267475-6f4h3cck 1012 85 on on IN cord-267475-6f4h3cck 1012 86 BRCA1 BRCA1 NNP cord-267475-6f4h3cck 1012 87 can can MD cord-267475-6f4h3cck 1012 88 generate generate VB cord-267475-6f4h3cck 1012 89 the the DT cord-267475-6f4h3cck 1012 90 novel novel JJ cord-267475-6f4h3cck 1012 91 isoform isoform NN cord-267475-6f4h3cck 1012 92 protein protein NN cord-267475-6f4h3cck 1012 93 DBRCA1(17aa DBRCA1(17aa NNP cord-267475-6f4h3cck 1012 94 ) ) -RRB- cord-267475-6f4h3cck 1013 1 The the DT cord-267475-6f4h3cck 1013 2 retinoblastoma retinoblastoma NN cord-267475-6f4h3cck 1013 3 interacting interact VBG cord-267475-6f4h3cck 1014 1 zinc zinc NNP cord-267475-6f4h3cck 1014 2 finger finger NN cord-267475-6f4h3cck 1014 3 gene gene NN cord-267475-6f4h3cck 1014 4 RIZ RIZ NNP cord-267475-6f4h3cck 1014 5 produces produce VBZ cord-267475-6f4h3cck 1014 6 a a DT cord-267475-6f4h3cck 1014 7 PR PR NNP cord-267475-6f4h3cck 1014 8 domain domain NN cord-267475-6f4h3cck 1014 9 - - HYPH cord-267475-6f4h3cck 1014 10 lacking lack VBG cord-267475-6f4h3cck 1014 11 product product NN cord-267475-6f4h3cck 1014 12 through through IN cord-267475-6f4h3cck 1014 13 an an DT cord-267475-6f4h3cck 1014 14 internal internal JJ cord-267475-6f4h3cck 1014 15 promoter promoter NN cord-267475-6f4h3cck 1014 16 Mutation Mutation NNP cord-267475-6f4h3cck 1014 17 of of IN cord-267475-6f4h3cck 1014 18 the the DT cord-267475-6f4h3cck 1014 19 CDKN2A CDKN2A NNP cord-267475-6f4h3cck 1014 20 5 5 CD cord-267475-6f4h3cck 1014 21 0 0 CD cord-267475-6f4h3cck 1015 1 UTR UTR NNP cord-267475-6f4h3cck 1015 2 creates create VBZ cord-267475-6f4h3cck 1015 3 an an DT cord-267475-6f4h3cck 1015 4 aberrant aberrant JJ cord-267475-6f4h3cck 1015 5 initiation initiation NN cord-267475-6f4h3cck 1015 6 codon codon NN cord-267475-6f4h3cck 1015 7 and and CC cord-267475-6f4h3cck 1015 8 predisposes predispose VBZ cord-267475-6f4h3cck 1015 9 to to IN cord-267475-6f4h3cck 1015 10 melanoma melanoma NN cord-267475-6f4h3cck 1016 1 The the DT cord-267475-6f4h3cck 1016 2 human human JJ cord-267475-6f4h3cck 1016 3 cytomegalovirus cytomegalovirus NN cord-267475-6f4h3cck 1016 4 UL35 UL35 NNP cord-267475-6f4h3cck 1016 5 gene gene NN cord-267475-6f4h3cck 1016 6 encodes encode VBZ cord-267475-6f4h3cck 1016 7 two two CD cord-267475-6f4h3cck 1016 8 proteins protein NNS cord-267475-6f4h3cck 1016 9 with with IN cord-267475-6f4h3cck 1016 10 different different JJ cord-267475-6f4h3cck 1016 11 functions function NNS cord-267475-6f4h3cck 1016 12 RNA RNA NNP cord-267475-6f4h3cck 1016 13 polymerase polymerase NN cord-267475-6f4h3cck 1016 14 I I NNP cord-267475-6f4h3cck 1016 15 - - HYPH cord-267475-6f4h3cck 1016 16 promoted promote VBN cord-267475-6f4h3cck 1016 17 HIS4 HIS4 NNP cord-267475-6f4h3cck 1016 18 expression expression NN cord-267475-6f4h3cck 1016 19 yields yield NNS cord-267475-6f4h3cck 1016 20 uncapped uncapped JJ cord-267475-6f4h3cck 1016 21 , , , cord-267475-6f4h3cck 1016 22 polyadenylated polyadenylated JJ cord-267475-6f4h3cck 1016 23 mRNA mrna NN cord-267475-6f4h3cck 1017 1 that that DT cord-267475-6f4h3cck 1017 2 is be VBZ cord-267475-6f4h3cck 1017 3 unstable unstable JJ cord-267475-6f4h3cck 1017 4 and and CC cord-267475-6f4h3cck 1017 5 inefficiently inefficiently RB cord-267475-6f4h3cck 1017 6 translated translate VBN cord-267475-6f4h3cck 1017 7 in in IN cord-267475-6f4h3cck 1017 8 Saccharomyces Saccharomyces NNP cord-267475-6f4h3cck 1017 9 cerevisiae cerevisiae VBZ cord-267475-6f4h3cck 1017 10 Two two CD cord-267475-6f4h3cck 1017 11 isoforms isoform NNS cord-267475-6f4h3cck 1017 12 of of IN cord-267475-6f4h3cck 1017 13 murine murine JJ cord-267475-6f4h3cck 1017 14 hck hck NN cord-267475-6f4h3cck 1017 15 , , , cord-267475-6f4h3cck 1017 16 generated generate VBN cord-267475-6f4h3cck 1017 17 by by IN cord-267475-6f4h3cck 1017 18 utilization utilization NN cord-267475-6f4h3cck 1017 19 of of IN cord-267475-6f4h3cck 1017 20 alternative alternative JJ cord-267475-6f4h3cck 1017 21 translational translational JJ cord-267475-6f4h3cck 1017 22 initiation initiation NN cord-267475-6f4h3cck 1017 23 codons codon NNS cord-267475-6f4h3cck 1017 24 , , , cord-267475-6f4h3cck 1017 25 exhibit exhibit VBP cord-267475-6f4h3cck 1017 26 different different JJ cord-267475-6f4h3cck 1017 27 patterns pattern NNS cord-267475-6f4h3cck 1017 28 of of IN cord-267475-6f4h3cck 1017 29 subcellular subcellular JJ cord-267475-6f4h3cck 1017 30 localization localization NN cord-267475-6f4h3cck 1018 1 The the DT cord-267475-6f4h3cck 1018 2 human human NN cord-267475-6f4h3cck 1018 3 AQP4 AQP4 NNP cord-267475-6f4h3cck 1018 4 gene gene NN cord-267475-6f4h3cck 1018 5 : : : cord-267475-6f4h3cck 1018 6 definition definition NN cord-267475-6f4h3cck 1018 7 of of IN cord-267475-6f4h3cck 1018 8 the the DT cord-267475-6f4h3cck 1018 9 locus locus NN cord-267475-6f4h3cck 1018 10 encoding encode VBG cord-267475-6f4h3cck 1018 11 two two CD cord-267475-6f4h3cck 1018 12 water water NN cord-267475-6f4h3cck 1018 13 channel channel NN cord-267475-6f4h3cck 1018 14 polypeptides polypeptide NNS cord-267475-6f4h3cck 1018 15 in in IN cord-267475-6f4h3cck 1018 16 brain brain NN cord-267475-6f4h3cck 1018 17 Cloning cloning NN cord-267475-6f4h3cck 1018 18 and and CC cord-267475-6f4h3cck 1018 19 origin origin NN cord-267475-6f4h3cck 1018 20 of of IN cord-267475-6f4h3cck 1018 21 the the DT cord-267475-6f4h3cck 1018 22 two two CD cord-267475-6f4h3cck 1018 23 forms form NNS cord-267475-6f4h3cck 1018 24 of of IN cord-267475-6f4h3cck 1018 25 chicken chicken NN cord-267475-6f4h3cck 1018 26 vitamin vitamin NN cord-267475-6f4h3cck 1018 27 D D NNP cord-267475-6f4h3cck 1018 28 receptor receptor NN cord-267475-6f4h3cck 1019 1 In in IN cord-267475-6f4h3cck 1019 2 vivo vivo NN cord-267475-6f4h3cck 1019 3 evaluation evaluation NN cord-267475-6f4h3cck 1019 4 of of IN cord-267475-6f4h3cck 1019 5 the the DT cord-267475-6f4h3cck 1019 6 context context NN cord-267475-6f4h3cck 1019 7 sequence sequence NN cord-267475-6f4h3cck 1019 8 of of IN cord-267475-6f4h3cck 1019 9 the the DT cord-267475-6f4h3cck 1019 10 translation translation NN cord-267475-6f4h3cck 1019 11 initiation initiation NN cord-267475-6f4h3cck 1019 12 codon codon NN cord-267475-6f4h3cck 1019 13 in in IN cord-267475-6f4h3cck 1019 14 plants plant NNS cord-267475-6f4h3cck 1019 15 Alternative alternative JJ cord-267475-6f4h3cck 1019 16 splicing splicing NN cord-267475-6f4h3cck 1019 17 and and CC cord-267475-6f4h3cck 1019 18 promoter promoter NN cord-267475-6f4h3cck 1019 19 usage usage NN cord-267475-6f4h3cck 1019 20 generates generate VBZ cord-267475-6f4h3cck 1019 21 an an DT cord-267475-6f4h3cck 1019 22 intracellular intracellular JJ cord-267475-6f4h3cck 1019 23 stromelysin stromelysin NNS cord-267475-6f4h3cck 1019 24 3 3 CD cord-267475-6f4h3cck 1019 25 isoform isoform NN cord-267475-6f4h3cck 1019 26 directly directly RB cord-267475-6f4h3cck 1019 27 translated translate VBN cord-267475-6f4h3cck 1019 28 as as IN cord-267475-6f4h3cck 1019 29 an an DT cord-267475-6f4h3cck 1019 30 active active JJ cord-267475-6f4h3cck 1019 31 matrix matrix NN cord-267475-6f4h3cck 1019 32 metalloproteinase metalloproteinase NN cord-267475-6f4h3cck 1019 33 Efficiency efficiency NN cord-267475-6f4h3cck 1019 34 of of IN cord-267475-6f4h3cck 1019 35 reinitiation reinitiation NN cord-267475-6f4h3cck 1019 36 of of IN cord-267475-6f4h3cck 1019 37 translation translation NN cord-267475-6f4h3cck 1019 38 on on IN cord-267475-6f4h3cck 1019 39 human human JJ cord-267475-6f4h3cck 1019 40 immunodeficiency immunodeficiency NN cord-267475-6f4h3cck 1019 41 virus virus NN cord-267475-6f4h3cck 1019 42 type type NN cord-267475-6f4h3cck 1019 43 1 1 CD cord-267475-6f4h3cck 1019 44 mRNAs mRNAs NNPS cord-267475-6f4h3cck 1019 45 is be VBZ cord-267475-6f4h3cck 1019 46 determined determine VBN cord-267475-6f4h3cck 1019 47 by by IN cord-267475-6f4h3cck 1019 48 the the DT cord-267475-6f4h3cck 1019 49 length length NN cord-267475-6f4h3cck 1019 50 of of IN cord-267475-6f4h3cck 1019 51 the the DT cord-267475-6f4h3cck 1019 52 upstream upstream JJ cord-267475-6f4h3cck 1019 53 open open JJ cord-267475-6f4h3cck 1019 54 reading reading NN cord-267475-6f4h3cck 1019 55 frame frame NN cord-267475-6f4h3cck 1019 56 and and CC cord-267475-6f4h3cck 1019 57 by by IN cord-267475-6f4h3cck 1019 58 intercistronic intercistronic JJ cord-267475-6f4h3cck 1019 59 distance distance NNP cord-267475-6f4h3cck 1019 60 Expression Expression NNP cord-267475-6f4h3cck 1019 61 of of IN cord-267475-6f4h3cck 1019 62 NFAT NFAT NNP cord-267475-6f4h3cck 1019 63 - - HYPH cord-267475-6f4h3cck 1019 64 family family NN cord-267475-6f4h3cck 1019 65 proteins protein NNS cord-267475-6f4h3cck 1019 66 in in IN cord-267475-6f4h3cck 1019 67 normal normal JJ cord-267475-6f4h3cck 1019 68 human human JJ cord-267475-6f4h3cck 1019 69 T t NN cord-267475-6f4h3cck 1019 70 cells cell NNS cord-267475-6f4h3cck 1020 1 An an DT cord-267475-6f4h3cck 1020 2 alternative alternative JJ cord-267475-6f4h3cck 1020 3 promoter promoter NN cord-267475-6f4h3cck 1020 4 in in IN cord-267475-6f4h3cck 1020 5 the the DT cord-267475-6f4h3cck 1020 6 mouse mouse NN cord-267475-6f4h3cck 1020 7 major major JJ cord-267475-6f4h3cck 1020 8 histocompatibility histocompatibility NN cord-267475-6f4h3cck 1020 9 complex complex JJ cord-267475-6f4h3cck 1020 10 class class NN cord-267475-6f4h3cck 1020 11 II ii NN cord-267475-6f4h3cck 1021 1 I -PRON- PRP cord-267475-6f4h3cck 1021 2 - - HYPH cord-267475-6f4h3cck 1021 3 Ab Ab NNP cord-267475-6f4h3cck 1021 4 gene gene NN cord-267475-6f4h3cck 1021 5 : : : cord-267475-6f4h3cck 1021 6 implications implication NNS cord-267475-6f4h3cck 1021 7 for for IN cord-267475-6f4h3cck 1021 8 the the DT cord-267475-6f4h3cck 1021 9 origin origin NN cord-267475-6f4h3cck 1021 10 of of IN cord-267475-6f4h3cck 1021 11 CpG CpG NNP cord-267475-6f4h3cck 1021 12 islands islands NNPS cord-267475-6f4h3cck 1021 13 Regulation Regulation NNP cord-267475-6f4h3cck 1021 14 of of IN cord-267475-6f4h3cck 1021 15 rat rat NN cord-267475-6f4h3cck 1021 16 ornithine ornithine NN cord-267475-6f4h3cck 1021 17 decarboxylase decarboxylase NN cord-267475-6f4h3cck 1022 1 mRNA mrna NN cord-267475-6f4h3cck 1022 2 translation translation NN cord-267475-6f4h3cck 1022 3 by by IN cord-267475-6f4h3cck 1022 4 its -PRON- PRP$ cord-267475-6f4h3cck 1022 5 5 5 CD cord-267475-6f4h3cck 1022 6 0 0 CD cord-267475-6f4h3cck 1022 7 -untranslated -untranslated JJ cord-267475-6f4h3cck 1022 8 region region NN cord-267475-6f4h3cck 1022 9 Translational translational JJ cord-267475-6f4h3cck 1022 10 activation activation NN cord-267475-6f4h3cck 1022 11 of of IN cord-267475-6f4h3cck 1022 12 the the DT cord-267475-6f4h3cck 1022 13 lck lck NNP cord-267475-6f4h3cck 1022 14 proto proto JJ cord-267475-6f4h3cck 1022 15 - - HYPH cord-267475-6f4h3cck 1022 16 oncogene oncogene NN cord-267475-6f4h3cck 1022 17 An an DT cord-267475-6f4h3cck 1022 18 alternative alternative JJ cord-267475-6f4h3cck 1022 19 mode mode NN cord-267475-6f4h3cck 1022 20 of of IN cord-267475-6f4h3cck 1022 21 translation translation NN cord-267475-6f4h3cck 1022 22 permits permit VBZ cord-267475-6f4h3cck 1022 23 production production NN cord-267475-6f4h3cck 1022 24 of of IN cord-267475-6f4h3cck 1022 25 a a DT cord-267475-6f4h3cck 1022 26 variant variant JJ cord-267475-6f4h3cck 1022 27 NBS1 NBS1 NNP cord-267475-6f4h3cck 1022 28 protein protein NN cord-267475-6f4h3cck 1022 29 from from IN cord-267475-6f4h3cck 1022 30 the the DT cord-267475-6f4h3cck 1022 31 common common JJ cord-267475-6f4h3cck 1022 32 Nijmegen Nijmegen NNP cord-267475-6f4h3cck 1022 33 breakage breakage NN cord-267475-6f4h3cck 1022 34 syndrome syndrome NN cord-267475-6f4h3cck 1022 35 allele allele NN cord-267475-6f4h3cck 1022 36 Lost lose VBN cord-267475-6f4h3cck 1022 37 in in IN cord-267475-6f4h3cck 1022 38 translation translation NN cord-267475-6f4h3cck 1022 39 Molecular molecular JJ cord-267475-6f4h3cck 1022 40 biology biology NN cord-267475-6f4h3cck 1022 41 of of IN cord-267475-6f4h3cck 1022 42 luteoviruses luteoviruses NNP cord-267475-6f4h3cck 1023 1 Posttranscriptional posttranscriptional JJ cord-267475-6f4h3cck 1023 2 control control NN cord-267475-6f4h3cck 1023 3 of of IN cord-267475-6f4h3cck 1023 4 gene gene NN cord-267475-6f4h3cck 1023 5 expression expression NN cord-267475-6f4h3cck 1023 6 in in IN cord-267475-6f4h3cck 1023 7 yeast yeast NN cord-267475-6f4h3cck 1023 8 . . . cord-267475-6f4h3cck 1024 1 Microbiol Microbiol NNP cord-267475-6f4h3cck 1024 2 Isolation Isolation NNP cord-267475-6f4h3cck 1024 3 , , , cord-267475-6f4h3cck 1024 4 characterization characterization NN cord-267475-6f4h3cck 1024 5 , , , cord-267475-6f4h3cck 1024 6 and and CC cord-267475-6f4h3cck 1024 7 transcription transcription NN cord-267475-6f4h3cck 1024 8 of of IN cord-267475-6f4h3cck 1024 9 the the DT cord-267475-6f4h3cck 1024 10 gene gene NN cord-267475-6f4h3cck 1024 11 encoding encode VBG cord-267475-6f4h3cck 1024 12 mouse mouse NN cord-267475-6f4h3cck 1024 13 mast mast NN cord-267475-6f4h3cck 1024 14 cell cell NN cord-267475-6f4h3cck 1024 15 protease protease NN cord-267475-6f4h3cck 1024 16 7 7 CD cord-267475-6f4h3cck 1024 17 Translational translational JJ cord-267475-6f4h3cck 1024 18 control control NN cord-267475-6f4h3cck 1024 19 of of IN cord-267475-6f4h3cck 1024 20 the the DT cord-267475-6f4h3cck 1024 21 Xenopus Xenopus NNP cord-267475-6f4h3cck 1024 22 laevis laevi NNS cord-267475-6f4h3cck 1024 23 connexin-41 connexin-41 NN cord-267475-6f4h3cck 1024 24 5 5 CD cord-267475-6f4h3cck 1024 25 0 0 CD cord-267475-6f4h3cck 1024 26 -untranslated -untranslated JJ cord-267475-6f4h3cck 1024 27 region region NN cord-267475-6f4h3cck 1024 28 by by IN cord-267475-6f4h3cck 1024 29 three three CD cord-267475-6f4h3cck 1024 30 upstream upstream RB cord-267475-6f4h3cck 1024 31 open open JJ cord-267475-6f4h3cck 1024 32 reading reading NN cord-267475-6f4h3cck 1024 33 frames frame NNS cord-267475-6f4h3cck 1024 34 Human Human NNP cord-267475-6f4h3cck 1024 35 MxB mxb JJ cord-267475-6f4h3cck 1024 36 protein protein NN cord-267475-6f4h3cck 1024 37 , , , cord-267475-6f4h3cck 1024 38 an an DT cord-267475-6f4h3cck 1024 39 interferon interferon NN cord-267475-6f4h3cck 1024 40 - - HYPH cord-267475-6f4h3cck 1024 41 a a DT cord-267475-6f4h3cck 1024 42 - - HYPH cord-267475-6f4h3cck 1024 43 inducible inducible JJ cord-267475-6f4h3cck 1024 44 GTPase GTPase NNP cord-267475-6f4h3cck 1024 45 , , , cord-267475-6f4h3cck 1024 46 contains contain VBZ cord-267475-6f4h3cck 1024 47 a a DT cord-267475-6f4h3cck 1024 48 nuclear nuclear JJ cord-267475-6f4h3cck 1024 49 targeting targeting NN cord-267475-6f4h3cck 1024 50 signal signal NN cord-267475-6f4h3cck 1024 51 and and CC cord-267475-6f4h3cck 1024 52 is be VBZ cord-267475-6f4h3cck 1024 53 localized localize VBN cord-267475-6f4h3cck 1024 54 in in IN cord-267475-6f4h3cck 1024 55 the the DT cord-267475-6f4h3cck 1024 56 heterochromatin heterochromatin NN cord-267475-6f4h3cck 1024 57 region region NN cord-267475-6f4h3cck 1024 58 beneath beneath IN cord-267475-6f4h3cck 1024 59 the the DT cord-267475-6f4h3cck 1024 60 nuclear nuclear JJ cord-267475-6f4h3cck 1024 61 envelope envelope NN cord-267475-6f4h3cck 1024 62 Subgenomic Subgenomic NNP cord-267475-6f4h3cck 1024 63 RNAs rna NNS cord-267475-6f4h3cck 1024 64 mediate mediate VBP cord-267475-6f4h3cck 1024 65 expression expression NN cord-267475-6f4h3cck 1024 66 of of IN cord-267475-6f4h3cck 1024 67 cistrons cistron NNS cord-267475-6f4h3cck 1024 68 located locate VBN cord-267475-6f4h3cck 1024 69 internally internally RB cord-267475-6f4h3cck 1024 70 on on IN cord-267475-6f4h3cck 1024 71 the the DT cord-267475-6f4h3cck 1024 72 genomic genomic JJ cord-267475-6f4h3cck 1024 73 RNA RNA NNP cord-267475-6f4h3cck 1024 74 of of IN cord-267475-6f4h3cck 1024 75 tobacco tobacco NN cord-267475-6f4h3cck 1024 76 necrosis necrosis NN cord-267475-6f4h3cck 1024 77 virus virus NN cord-267475-6f4h3cck 1024 78 strain strain NN cord-267475-6f4h3cck 1025 1 A a DT cord-267475-6f4h3cck 1026 1 The the DT cord-267475-6f4h3cck 1026 2 three three CD cord-267475-6f4h3cck 1026 3 dominant dominant JJ cord-267475-6f4h3cck 1026 4 female female NN cord-267475-6f4h3cck 1026 5 - - HYPH cord-267475-6f4h3cck 1026 6 sterile sterile JJ cord-267475-6f4h3cck 1026 7 mutations mutation NNS cord-267475-6f4h3cck 1026 8 of of IN cord-267475-6f4h3cck 1026 9 the the DT cord-267475-6f4h3cck 1026 10 Drosophila Drosophila NNP cord-267475-6f4h3cck 1026 11 ovo ovo NNP cord-267475-6f4h3cck 1026 12 gene gene NN cord-267475-6f4h3cck 1026 13 are be VBP cord-267475-6f4h3cck 1026 14 point point NN cord-267475-6f4h3cck 1026 15 mutations mutation NNS cord-267475-6f4h3cck 1026 16 that that WDT cord-267475-6f4h3cck 1026 17 create create VBP cord-267475-6f4h3cck 1026 18 new new JJ cord-267475-6f4h3cck 1026 19 translation translation NN cord-267475-6f4h3cck 1026 20 - - HYPH cord-267475-6f4h3cck 1026 21 initiator initiator NN cord-267475-6f4h3cck 1026 22 AUG AUG NNP cord-267475-6f4h3cck 1026 23 codons codon NNS cord-267475-6f4h3cck 1026 24 Posttranscriptional Posttranscriptional NNP cord-267475-6f4h3cck 1026 25 control control NN cord-267475-6f4h3cck 1026 26 via via IN cord-267475-6f4h3cck 1026 27 iron iron NN cord-267475-6f4h3cck 1026 28 - - HYPH cord-267475-6f4h3cck 1026 29 responsive responsive JJ cord-267475-6f4h3cck 1026 30 elements element NNS cord-267475-6f4h3cck 1026 31 : : : cord-267475-6f4h3cck 1026 32 the the DT cord-267475-6f4h3cck 1026 33 impact impact NN cord-267475-6f4h3cck 1026 34 of of IN cord-267475-6f4h3cck 1026 35 aberrations aberration NNS cord-267475-6f4h3cck 1026 36 in in IN cord-267475-6f4h3cck 1026 37 hereditary hereditary JJ cord-267475-6f4h3cck 1026 38 disease disease NN cord-267475-6f4h3cck 1026 39 Synthesis Synthesis NNP cord-267475-6f4h3cck 1026 40 of of IN cord-267475-6f4h3cck 1026 41 subgenomic subgenomic NNP cord-267475-6f4h3cck 1026 42 RNAs RNAs NNPS cord-267475-6f4h3cck 1026 43 by by IN cord-267475-6f4h3cck 1026 44 positivestrand positivestrand NNP cord-267475-6f4h3cck 1026 45 RNA RNA NNP cord-267475-6f4h3cck 1026 46 viruses virus NNS cord-267475-6f4h3cck 1026 47 Synthesis Synthesis NNP cord-267475-6f4h3cck 1026 48 of of IN cord-267475-6f4h3cck 1026 49 brome brome NNP cord-267475-6f4h3cck 1026 50 mosaic mosaic NNP cord-267475-6f4h3cck 1026 51 virus virus NN cord-267475-6f4h3cck 1026 52 subgenomic subgenomic NNP cord-267475-6f4h3cck 1026 53 RNA RNA NNP cord-267475-6f4h3cck 1026 54 in in IN cord-267475-6f4h3cck 1026 55 vitro vitro FW cord-267475-6f4h3cck 1026 56 by by IN cord-267475-6f4h3cck 1026 57 internal internal JJ cord-267475-6f4h3cck 1026 58 initiation initiation NN cord-267475-6f4h3cck 1026 59 on on IN cord-267475-6f4h3cck 1026 60 ( ( -LRB- cord-267475-6f4h3cck 1026 61 2)-sense 2)-sense CD cord-267475-6f4h3cck 1026 62 genomic genomic JJ cord-267475-6f4h3cck 1026 63 RNA RNA NNP cord-267475-6f4h3cck 1026 64 Transforming transform VBG cord-267475-6f4h3cck 1026 65 growth growth NN cord-267475-6f4h3cck 1026 66 factor factor NN cord-267475-6f4h3cck 1027 1 -b -b SYM cord-267475-6f4h3cck 1027 2 1 1 CD cord-267475-6f4h3cck 1027 3 -mediated -mediated JJ cord-267475-6f4h3cck 1027 4 inhibition inhibition NN cord-267475-6f4h3cck 1027 5 of of IN cord-267475-6f4h3cck 1027 6 the the DT cord-267475-6f4h3cck 1027 7 flk-1 flk-1 NNP cord-267475-6f4h3cck 1027 8 / / SYM cord-267475-6f4h3cck 1027 9 KDR KDR NNP cord-267475-6f4h3cck 1027 10 gene gene NN cord-267475-6f4h3cck 1027 11 is be VBZ cord-267475-6f4h3cck 1027 12 mediated mediate VBN cord-267475-6f4h3cck 1027 13 by by IN cord-267475-6f4h3cck 1027 14 a a DT cord-267475-6f4h3cck 1027 15 5 5 CD cord-267475-6f4h3cck 1027 16 0 0 CD cord-267475-6f4h3cck 1027 17 -untranslated -untranslated JJ cord-267475-6f4h3cck 1027 18 region region NN cord-267475-6f4h3cck 1027 19 palindromic palindromic JJ cord-267475-6f4h3cck 1027 20 GATA GATA NNP cord-267475-6f4h3cck 1027 21 site site NN cord-267475-6f4h3cck 1027 22 Characterization characterization NN cord-267475-6f4h3cck 1027 23 of of IN cord-267475-6f4h3cck 1027 24 two two CD cord-267475-6f4h3cck 1027 25 novel novel JJ cord-267475-6f4h3cck 1027 26 nuclear nuclear JJ cord-267475-6f4h3cck 1027 27 BTB BTB NNP cord-267475-6f4h3cck 1027 28 / / SYM cord-267475-6f4h3cck 1027 29 POZ POZ NNP cord-267475-6f4h3cck 1027 30 domain domain NN cord-267475-6f4h3cck 1027 31 zinc zinc NN cord-267475-6f4h3cck 1027 32 finger finger NN cord-267475-6f4h3cck 1027 33 isoforms isoform NNS cord-267475-6f4h3cck 1027 34 . . . cord-267475-6f4h3cck 1028 1 Association Association NNP cord-267475-6f4h3cck 1028 2 with with IN cord-267475-6f4h3cck 1028 3 differentiation differentiation NN cord-267475-6f4h3cck 1028 4 of of IN cord-267475-6f4h3cck 1028 5 hippocampal hippocampal JJ cord-267475-6f4h3cck 1028 6 neurons neuron NNS cord-267475-6f4h3cck 1028 7 , , , cord-267475-6f4h3cck 1028 8 cerebellar cerebellar JJ cord-267475-6f4h3cck 1028 9 granule granule NN cord-267475-6f4h3cck 1028 10 cells cell NNS cord-267475-6f4h3cck 1028 11 , , , cord-267475-6f4h3cck 1028 12 and and CC cord-267475-6f4h3cck 1028 13 macroglia macroglia NNP cord-267475-6f4h3cck 1028 14 Regulation Regulation NNP cord-267475-6f4h3cck 1028 15 of of IN cord-267475-6f4h3cck 1028 16 expression expression NN cord-267475-6f4h3cck 1028 17 of of IN cord-267475-6f4h3cck 1028 18 the the DT cord-267475-6f4h3cck 1028 19 alternative alternative NN cord-267475-6f4h3cck 1028 20 mRNAs mrnas CD cord-267475-6f4h3cck 1028 21 of of IN cord-267475-6f4h3cck 1028 22 the the DT cord-267475-6f4h3cck 1028 23 rat rat NN cord-267475-6f4h3cck 1028 24 a a DT cord-267475-6f4h3cck 1028 25 - - HYPH cord-267475-6f4h3cck 1028 26 thyroid thyroid NN cord-267475-6f4h3cck 1028 27 hormone hormone NN cord-267475-6f4h3cck 1028 28 receptor receptor NN cord-267475-6f4h3cck 1028 29 gene gene NN cord-267475-6f4h3cck 1029 1 Differential differential JJ cord-267475-6f4h3cck 1029 2 translational translational JJ cord-267475-6f4h3cck 1029 3 initiation initiation NN cord-267475-6f4h3cck 1029 4 of of IN cord-267475-6f4h3cck 1029 5 lbp lbp NNP cord-267475-6f4h3cck 1029 6 mRNA mRNA NNP cord-267475-6f4h3cck 1029 7 is be VBZ cord-267475-6f4h3cck 1029 8 caused cause VBN cord-267475-6f4h3cck 1029 9 by by IN cord-267475-6f4h3cck 1029 10 a a DT cord-267475-6f4h3cck 1029 11 5 5 CD cord-267475-6f4h3cck 1029 12 0 0 CD cord-267475-6f4h3cck 1029 13 upstream upstream NN cord-267475-6f4h3cck 1029 14 open open JJ cord-267475-6f4h3cck 1029 15 reading reading NN cord-267475-6f4h3cck 1029 16 frame frame NN cord-267475-6f4h3cck 1029 17 Identification identification NN cord-267475-6f4h3cck 1029 18 of of IN cord-267475-6f4h3cck 1029 19 murine murine JJ cord-267475-6f4h3cck 1029 20 p120 p120 NNP cord-267475-6f4h3cck 1029 21 cas cas NNP cord-267475-6f4h3cck 1029 22 isoforms isoform NNS cord-267475-6f4h3cck 1029 23 and and CC cord-267475-6f4h3cck 1029 24 heterogeneous heterogeneous JJ cord-267475-6f4h3cck 1029 25 expression expression NN cord-267475-6f4h3cck 1029 26 of of IN cord-267475-6f4h3cck 1029 27 p120 p120 NNP cord-267475-6f4h3cck 1029 28 cas cas NNP cord-267475-6f4h3cck 1029 29 isoforms isoform NNS cord-267475-6f4h3cck 1029 30 in in IN cord-267475-6f4h3cck 1029 31 human human JJ cord-267475-6f4h3cck 1029 32 tumor tumor NN cord-267475-6f4h3cck 1029 33 cell cell NN cord-267475-6f4h3cck 1029 34 lines line NNS cord-267475-6f4h3cck 1029 35 Inducibility Inducibility NNP cord-267475-6f4h3cck 1029 36 and and CC cord-267475-6f4h3cck 1029 37 negative negative JJ cord-267475-6f4h3cck 1029 38 autoregulation autoregulation NN cord-267475-6f4h3cck 1029 39 of of IN cord-267475-6f4h3cck 1029 40 CREM CREM NNP cord-267475-6f4h3cck 1029 41 : : : cord-267475-6f4h3cck 1029 42 an an DT cord-267475-6f4h3cck 1029 43 alternative alternative JJ cord-267475-6f4h3cck 1029 44 promoter promoter NN cord-267475-6f4h3cck 1029 45 directs direct VBZ cord-267475-6f4h3cck 1029 46 the the DT cord-267475-6f4h3cck 1029 47 expression expression NN cord-267475-6f4h3cck 1029 48 of of IN cord-267475-6f4h3cck 1029 49 ICER ICER NNP cord-267475-6f4h3cck 1029 50 , , , cord-267475-6f4h3cck 1029 51 an an DT cord-267475-6f4h3cck 1029 52 early early JJ cord-267475-6f4h3cck 1029 53 response response NN cord-267475-6f4h3cck 1029 54 repressor repressor NN cord-267475-6f4h3cck 1029 55 a a DT cord-267475-6f4h3cck 1029 56 - - HYPH cord-267475-6f4h3cck 1029 57 Thalassaemia thalassaemia NN cord-267475-6f4h3cck 1029 58 associated associate VBN cord-267475-6f4h3cck 1029 59 with with IN cord-267475-6f4h3cck 1029 60 the the DT cord-267475-6f4h3cck 1029 61 deletion deletion NN cord-267475-6f4h3cck 1029 62 of of IN cord-267475-6f4h3cck 1029 63 two two CD cord-267475-6f4h3cck 1029 64 nucleotides nucleotide NNS cord-267475-6f4h3cck 1029 65 at at IN cord-267475-6f4h3cck 1029 66 position position NN cord-267475-6f4h3cck 1029 67 22 22 CD cord-267475-6f4h3cck 1029 68 and and CC cord-267475-6f4h3cck 1029 69 23 23 CD cord-267475-6f4h3cck 1029 70 preceding precede VBG cord-267475-6f4h3cck 1029 71 the the DT cord-267475-6f4h3cck 1029 72 AUG AUG NNP cord-267475-6f4h3cck 1029 73 codon codon NN cord-267475-6f4h3cck 1029 74 Upstream upstream IN cord-267475-6f4h3cck 1029 75 open open JJ cord-267475-6f4h3cck 1029 76 reading reading NN cord-267475-6f4h3cck 1029 77 frames frame NNS cord-267475-6f4h3cck 1029 78 as as IN cord-267475-6f4h3cck 1029 79 regulators regulator NNS cord-267475-6f4h3cck 1029 80 of of IN cord-267475-6f4h3cck 1029 81 mRNA mRNA NNP cord-267475-6f4h3cck 1029 82 translation translation NN cord-267475-6f4h3cck 1030 1 The the DT cord-267475-6f4h3cck 1030 2 5 5 CD cord-267475-6f4h3cck 1030 3 0 0 CD cord-267475-6f4h3cck 1030 4 UTR UTR NNP cord-267475-6f4h3cck 1030 5 of of IN cord-267475-6f4h3cck 1030 6 protein protein NN cord-267475-6f4h3cck 1030 7 kinase kinase NN cord-267475-6f4h3cck 1030 8 C C NNP cord-267475-6f4h3cck 1030 9 1 1 CD cord-267475-6f4h3cck 1030 10 confers confer VBZ cord-267475-6f4h3cck 1030 11 translational translational JJ cord-267475-6f4h3cck 1030 12 regulation regulation NN cord-267475-6f4h3cck 1030 13 in in IN cord-267475-6f4h3cck 1030 14 vitro vitro FW cord-267475-6f4h3cck 1030 15 and and CC cord-267475-6f4h3cck 1030 16 in in IN cord-267475-6f4h3cck 1030 17 vivo vivo NNP cord-267475-6f4h3cck 1030 18 Complex Complex NNP cord-267475-6f4h3cck 1030 19 organisation organisation NN cord-267475-6f4h3cck 1030 20 of of IN cord-267475-6f4h3cck 1030 21 the the DT cord-267475-6f4h3cck 1030 22 5 5 CD cord-267475-6f4h3cck 1030 23 0 0 CD cord-267475-6f4h3cck 1030 24 -end -end : cord-267475-6f4h3cck 1030 25 of of IN cord-267475-6f4h3cck 1030 26 the the DT cord-267475-6f4h3cck 1030 27 human human JJ cord-267475-6f4h3cck 1030 28 glycine glycine NN cord-267475-6f4h3cck 1030 29 tRNA tRNA NNP cord-267475-6f4h3cck 1030 30 synthetase synthetase NNP cord-267475-6f4h3cck 1030 31 gene gene NN cord-267475-6f4h3cck 1030 32 Mapping mapping NN cord-267475-6f4h3cck 1030 33 of of IN cord-267475-6f4h3cck 1030 34 the the DT cord-267475-6f4h3cck 1030 35 polycistronic polycistronic JJ cord-267475-6f4h3cck 1030 36 RNAs rna NNS cord-267475-6f4h3cck 1030 37 of of IN cord-267475-6f4h3cck 1030 38 tomato tomato NN cord-267475-6f4h3cck 1030 39 leaf leaf NN cord-267475-6f4h3cck 1030 40 curl curl NN cord-267475-6f4h3cck 1030 41 geminivirus geminivirus NNP cord-267475-6f4h3cck 1030 42 Site site NN cord-267475-6f4h3cck 1030 43 - - HYPH cord-267475-6f4h3cck 1030 44 directed direct VBN cord-267475-6f4h3cck 1030 45 mutagenesis mutagenesis NN cord-267475-6f4h3cck 1030 46 of of IN cord-267475-6f4h3cck 1030 47 adeno adeno NN cord-267475-6f4h3cck 1030 48 - - HYPH cord-267475-6f4h3cck 1030 49 associated associate VBN cord-267475-6f4h3cck 1030 50 virus virus NN cord-267475-6f4h3cck 1030 51 type type NN cord-267475-6f4h3cck 1030 52 2 2 CD cord-267475-6f4h3cck 1030 53 structural structural JJ cord-267475-6f4h3cck 1030 54 protein protein NN cord-267475-6f4h3cck 1030 55 initiation initiation NN cord-267475-6f4h3cck 1030 56 codons codon NNS cord-267475-6f4h3cck 1030 57 : : : cord-267475-6f4h3cck 1030 58 effects effect NNS cord-267475-6f4h3cck 1030 59 on on IN cord-267475-6f4h3cck 1030 60 regulation regulation NN cord-267475-6f4h3cck 1030 61 of of IN cord-267475-6f4h3cck 1030 62 synthesis synthesis NN cord-267475-6f4h3cck 1030 63 and and CC cord-267475-6f4h3cck 1030 64 biological biological JJ cord-267475-6f4h3cck 1030 65 activity activity NN cord-267475-6f4h3cck 1030 66 Specific specific JJ cord-267475-6f4h3cck 1030 67 cleavage cleavage NN cord-267475-6f4h3cck 1030 68 of of IN cord-267475-6f4h3cck 1030 69 hepatitis hepatitis NN cord-267475-6f4h3cck 1030 70 C C NNP cord-267475-6f4h3cck 1030 71 virus virus NN cord-267475-6f4h3cck 1030 72 RNA RNA NNP cord-267475-6f4h3cck 1030 73 genome genome NN cord-267475-6f4h3cck 1030 74 by by IN cord-267475-6f4h3cck 1030 75 human human JJ cord-267475-6f4h3cck 1030 76 RNase rnase NN cord-267475-6f4h3cck 1030 77 P P NNP cord-267475-6f4h3cck 1030 78 Expression expression NN cord-267475-6f4h3cck 1030 79 of of IN cord-267475-6f4h3cck 1030 80 Kaposi Kaposi NNP cord-267475-6f4h3cck 1030 81 's 's POS cord-267475-6f4h3cck 1030 82 sarcoma sarcoma NN cord-267475-6f4h3cck 1030 83 - - HYPH cord-267475-6f4h3cck 1030 84 associated associate VBN cord-267475-6f4h3cck 1030 85 herpesvirus herpesvirus NN cord-267475-6f4h3cck 1030 86 G g NN cord-267475-6f4h3cck 1030 87 protein protein NN cord-267475-6f4h3cck 1030 88 - - HYPH cord-267475-6f4h3cck 1030 89 coupled couple VBN cord-267475-6f4h3cck 1030 90 receptor receptor NN cord-267475-6f4h3cck 1030 91 monocistronic monocistronic NN cord-267475-6f4h3cck 1030 92 and and CC cord-267475-6f4h3cck 1030 93 bicistronic bicistronic JJ cord-267475-6f4h3cck 1030 94 transcripts transcript NNS cord-267475-6f4h3cck 1030 95 in in IN cord-267475-6f4h3cck 1030 96 primary primary JJ cord-267475-6f4h3cck 1030 97 effusion effusion NN cord-267475-6f4h3cck 1030 98 lymphocytes lymphocyte VBZ cord-267475-6f4h3cck 1030 99 RAR RAR NNP cord-267475-6f4h3cck 1030 100 - - HYPH cord-267475-6f4h3cck 1030 101 b4 b4 NNP cord-267475-6f4h3cck 1030 102 , , , cord-267475-6f4h3cck 1030 103 a a DT cord-267475-6f4h3cck 1030 104 retinoic retinoic JJ cord-267475-6f4h3cck 1030 105 acid acid NN cord-267475-6f4h3cck 1030 106 receptor receptor NN cord-267475-6f4h3cck 1030 107 isoform isoform NN cord-267475-6f4h3cck 1030 108 is be VBZ cord-267475-6f4h3cck 1030 109 generated generate VBN cord-267475-6f4h3cck 1030 110 from from IN cord-267475-6f4h3cck 1030 111 RAR rar NN cord-267475-6f4h3cck 1030 112 - - HYPH cord-267475-6f4h3cck 1030 113 b2 b2 NN cord-267475-6f4h3cck 1030 114 by by IN cord-267475-6f4h3cck 1030 115 alternative alternative JJ cord-267475-6f4h3cck 1030 116 splicing splicing NN cord-267475-6f4h3cck 1030 117 and and CC cord-267475-6f4h3cck 1030 118 usage usage NN cord-267475-6f4h3cck 1030 119 of of IN cord-267475-6f4h3cck 1030 120 a a DT cord-267475-6f4h3cck 1030 121 CUG CUG NNP cord-267475-6f4h3cck 1030 122 initiator initiator NN cord-267475-6f4h3cck 1030 123 codon codon NN cord-267475-6f4h3cck 1031 1 The the DT cord-267475-6f4h3cck 1031 2 HTS1 HTS1 NNP cord-267475-6f4h3cck 1031 3 gene gene NN cord-267475-6f4h3cck 1031 4 encodes encode VBZ cord-267475-6f4h3cck 1031 5 both both PDT cord-267475-6f4h3cck 1031 6 the the DT cord-267475-6f4h3cck 1031 7 cytoplasmic cytoplasmic JJ cord-267475-6f4h3cck 1031 8 and and CC cord-267475-6f4h3cck 1031 9 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 1031 10 histidine histidine NN cord-267475-6f4h3cck 1031 11 tRNA tRNA NNP cord-267475-6f4h3cck 1031 12 synthetases synthetase NNS cord-267475-6f4h3cck 1031 13 of of IN cord-267475-6f4h3cck 1031 14 S. S. NNP cord-267475-6f4h3cck 1031 15 cerevisiae cerevisiae NN cord-267475-6f4h3cck 1031 16 Translation translation NN cord-267475-6f4h3cck 1031 17 of of IN cord-267475-6f4h3cck 1031 18 a a DT cord-267475-6f4h3cck 1031 19 nonpolyadenylated nonpolyadenylated JJ cord-267475-6f4h3cck 1031 20 viral viral JJ cord-267475-6f4h3cck 1031 21 RNA RNA NNP cord-267475-6f4h3cck 1031 22 is be VBZ cord-267475-6f4h3cck 1031 23 enhanced enhance VBN cord-267475-6f4h3cck 1031 24 by by IN cord-267475-6f4h3cck 1031 25 binding bind VBG cord-267475-6f4h3cck 1031 26 of of IN cord-267475-6f4h3cck 1031 27 viral viral JJ cord-267475-6f4h3cck 1031 28 coat coat NN cord-267475-6f4h3cck 1031 29 protein protein NN cord-267475-6f4h3cck 1031 30 or or CC cord-267475-6f4h3cck 1031 31 polyadenylation polyadenylation NN cord-267475-6f4h3cck 1031 32 of of IN cord-267475-6f4h3cck 1031 33 the the DT cord-267475-6f4h3cck 1031 34 RNA RNA NNP cord-267475-6f4h3cck 1031 35 Nucleotide Nucleotide NNP cord-267475-6f4h3cck 1031 36 sequence sequence NN cord-267475-6f4h3cck 1031 37 and and CC cord-267475-6f4h3cck 1031 38 expression expression NN cord-267475-6f4h3cck 1031 39 of of IN cord-267475-6f4h3cck 1031 40 the the DT cord-267475-6f4h3cck 1031 41 capsid capsid JJ cord-267475-6f4h3cck 1031 42 protein protein NN cord-267475-6f4h3cck 1031 43 gene gene NN cord-267475-6f4h3cck 1031 44 of of IN cord-267475-6f4h3cck 1031 45 feline feline JJ cord-267475-6f4h3cck 1031 46 calicivirus calicivirus NNP cord-267475-6f4h3cck 1031 47 Translational translational JJ cord-267475-6f4h3cck 1031 48 discrimination discrimination NN cord-267475-6f4h3cck 1031 49 of of IN cord-267475-6f4h3cck 1031 50 mRNAs mRNAs NNPS cord-267475-6f4h3cck 1031 51 coding code VBG cord-267475-6f4h3cck 1031 52 for for IN cord-267475-6f4h3cck 1031 53 human human JJ cord-267475-6f4h3cck 1031 54 insulin insulin NN cord-267475-6f4h3cck 1031 55 - - HYPH cord-267475-6f4h3cck 1031 56 like like JJ cord-267475-6f4h3cck 1031 57 growth growth NN cord-267475-6f4h3cck 1031 58 factor factor NN cord-267475-6f4h3cck 1031 59 II II NNP cord-267475-6f4h3cck 1031 60 Growthdependent Growthdependent NNP cord-267475-6f4h3cck 1031 61 translation translation NN cord-267475-6f4h3cck 1031 62 of of IN cord-267475-6f4h3cck 1031 63 IGF IGF NNP cord-267475-6f4h3cck 1031 64 - - HYPH cord-267475-6f4h3cck 1031 65 II II NNP cord-267475-6f4h3cck 1031 66 mRNA mrna NN cord-267475-6f4h3cck 1031 67 by by IN cord-267475-6f4h3cck 1031 68 a a DT cord-267475-6f4h3cck 1031 69 rapamycin rapamycin NN cord-267475-6f4h3cck 1031 70 - - HYPH cord-267475-6f4h3cck 1031 71 sensitive sensitive JJ cord-267475-6f4h3cck 1031 72 pathway pathway NN cord-267475-6f4h3cck 1031 73 Full full JJ cord-267475-6f4h3cck 1031 74 - - HYPH cord-267475-6f4h3cck 1031 75 sized sized JJ cord-267475-6f4h3cck 1031 76 RanBPM RanBPM NNP cord-267475-6f4h3cck 1031 77 cDNA cDNA NNP cord-267475-6f4h3cck 1031 78 encodes encode VBZ cord-267475-6f4h3cck 1031 79 a a DT cord-267475-6f4h3cck 1031 80 protein protein NN cord-267475-6f4h3cck 1031 81 possessing possess VBG cord-267475-6f4h3cck 1031 82 a a DT cord-267475-6f4h3cck 1031 83 long long JJ cord-267475-6f4h3cck 1031 84 stretch stretch NN cord-267475-6f4h3cck 1031 85 of of IN cord-267475-6f4h3cck 1031 86 proline proline NN cord-267475-6f4h3cck 1031 87 and and CC cord-267475-6f4h3cck 1031 88 glutamine glutamine NN cord-267475-6f4h3cck 1031 89 within within IN cord-267475-6f4h3cck 1031 90 the the DT cord-267475-6f4h3cck 1031 91 Nterminal Nterminal NNP cord-267475-6f4h3cck 1031 92 region region NN cord-267475-6f4h3cck 1031 93 , , , cord-267475-6f4h3cck 1031 94 comprising comprise VBG cord-267475-6f4h3cck 1031 95 a a DT cord-267475-6f4h3cck 1031 96 large large JJ cord-267475-6f4h3cck 1031 97 protein protein NN cord-267475-6f4h3cck 1031 98 complex complex NN cord-267475-6f4h3cck 1031 99 Human Human NNP cord-267475-6f4h3cck 1031 100 O O NNP cord-267475-6f4h3cck 1031 101 - - HYPH cord-267475-6f4h3cck 1031 102 GlcNAc glcnac NN cord-267475-6f4h3cck 1031 103 transferase transferase NN cord-267475-6f4h3cck 1031 104 ( ( -LRB- cord-267475-6f4h3cck 1031 105 OGT OGT NNP cord-267475-6f4h3cck 1031 106 ) ) -RRB- cord-267475-6f4h3cck 1031 107 : : : cord-267475-6f4h3cck 1031 108 genomic genomic JJ cord-267475-6f4h3cck 1031 109 structure structure NN cord-267475-6f4h3cck 1031 110 , , , cord-267475-6f4h3cck 1031 111 analysis analysis NN cord-267475-6f4h3cck 1031 112 of of IN cord-267475-6f4h3cck 1031 113 splice splice NN cord-267475-6f4h3cck 1031 114 variants variant NNS cord-267475-6f4h3cck 1031 115 , , , cord-267475-6f4h3cck 1031 116 fine fine JJ cord-267475-6f4h3cck 1031 117 mapping mapping NN cord-267475-6f4h3cck 1031 118 in in IN cord-267475-6f4h3cck 1031 119 Xq13 Xq13 . cord-267475-6f4h3cck 1031 120 Tissue tissue NN cord-267475-6f4h3cck 1031 121 - - HYPH cord-267475-6f4h3cck 1031 122 specific specific JJ cord-267475-6f4h3cck 1031 123 initiation initiation NN cord-267475-6f4h3cck 1031 124 of of IN cord-267475-6f4h3cck 1031 125 murine murine JJ cord-267475-6f4h3cck 1031 126 complement complement NN cord-267475-6f4h3cck 1031 127 factor factor NN cord-267475-6f4h3cck 1031 128 B B NNP cord-267475-6f4h3cck 1031 129 mRNA mrna NN cord-267475-6f4h3cck 1031 130 transcription transcription NN cord-267475-6f4h3cck 1031 131 Downstream Downstream NNP cord-267475-6f4h3cck 1031 132 ribosomal ribosomal JJ cord-267475-6f4h3cck 1031 133 entry entry NN cord-267475-6f4h3cck 1031 134 for for IN cord-267475-6f4h3cck 1031 135 translation translation NN cord-267475-6f4h3cck 1031 136 of of IN cord-267475-6f4h3cck 1031 137 coronavirus coronavirus NN cord-267475-6f4h3cck 1031 138 TGEV TGEV NNP cord-267475-6f4h3cck 1031 139 gene gene NN cord-267475-6f4h3cck 1031 140 3b 3b CD cord-267475-6f4h3cck 1031 141 Generation Generation NNP cord-267475-6f4h3cck 1031 142 from from IN cord-267475-6f4h3cck 1031 143 a a DT cord-267475-6f4h3cck 1031 144 single single JJ cord-267475-6f4h3cck 1031 145 gene gene NN cord-267475-6f4h3cck 1031 146 of of IN cord-267475-6f4h3cck 1031 147 two two CD cord-267475-6f4h3cck 1031 148 mRNAs mrna NNS cord-267475-6f4h3cck 1031 149 that that WDT cord-267475-6f4h3cck 1031 150 encode encode VBP cord-267475-6f4h3cck 1031 151 the the DT cord-267475-6f4h3cck 1031 152 mitochondrial mitochondrial NN cord-267475-6f4h3cck 1031 153 and and CC cord-267475-6f4h3cck 1031 154 peroxisomal peroxisomal JJ cord-267475-6f4h3cck 1031 155 serine serine NN cord-267475-6f4h3cck 1031 156 : : : cord-267475-6f4h3cck 1031 157 pyruvate pyruvate NNP cord-267475-6f4h3cck 1031 158 aminotransferase aminotransferase NN cord-267475-6f4h3cck 1031 159 of of IN cord-267475-6f4h3cck 1031 160 rat rat NN cord-267475-6f4h3cck 1031 161 liver liver NN cord-267475-6f4h3cck 1031 162 ABCD1 ABCD1 NNP cord-267475-6f4h3cck 1032 1 translation translation NN cord-267475-6f4h3cck 1032 2 - - HYPH cord-267475-6f4h3cck 1032 3 initiator initiator NN cord-267475-6f4h3cck 1032 4 mutation mutation NN cord-267475-6f4h3cck 1032 5 demonstrates demonstrate VBZ cord-267475-6f4h3cck 1032 6 genotype genotype NN cord-267475-6f4h3cck 1032 7 - - HYPH cord-267475-6f4h3cck 1032 8 phenotype phenotype NN cord-267475-6f4h3cck 1032 9 correlation correlation NN cord-267475-6f4h3cck 1032 10 for for IN cord-267475-6f4h3cck 1032 11 AMN AMN NNP cord-267475-6f4h3cck 1032 12 CCAAT CCAAT NNP cord-267475-6f4h3cck 1032 13 / / SYM cord-267475-6f4h3cck 1032 14 enhancer enhancer NN cord-267475-6f4h3cck 1032 15 - - HYPH cord-267475-6f4h3cck 1032 16 binding bind VBG cord-267475-6f4h3cck 1032 17 protein protein NN cord-267475-6f4h3cck 1032 18 mRNA mRNA NNP cord-267475-6f4h3cck 1032 19 is be VBZ cord-267475-6f4h3cck 1032 20 translated translate VBN cord-267475-6f4h3cck 1032 21 into into IN cord-267475-6f4h3cck 1032 22 multiple multiple JJ cord-267475-6f4h3cck 1032 23 proteins protein NNS cord-267475-6f4h3cck 1032 24 with with IN cord-267475-6f4h3cck 1032 25 different different JJ cord-267475-6f4h3cck 1032 26 transcription transcription NN cord-267475-6f4h3cck 1032 27 activation activation NN cord-267475-6f4h3cck 1032 28 potentials potential NNS cord-267475-6f4h3cck 1032 29 Dominant dominant JJ cord-267475-6f4h3cck 1032 30 - - HYPH cord-267475-6f4h3cck 1032 31 negative negative JJ cord-267475-6f4h3cck 1032 32 mutations mutation NNS cord-267475-6f4h3cck 1032 33 of of IN cord-267475-6f4h3cck 1032 34 CEBPA CEBPA NNP cord-267475-6f4h3cck 1032 35 , , , cord-267475-6f4h3cck 1032 36 encoding encode VBG cord-267475-6f4h3cck 1032 37 CCAAT CCAAT NNP cord-267475-6f4h3cck 1032 38 / / SYM cord-267475-6f4h3cck 1032 39 enhancer enhancer NN cord-267475-6f4h3cck 1032 40 binding bind VBG cord-267475-6f4h3cck 1032 41 protein protein NN cord-267475-6f4h3cck 1032 42 - - : cord-267475-6f4h3cck 1032 43 a a NN cord-267475-6f4h3cck 1032 44 ( ( -LRB- cord-267475-6f4h3cck 1032 45 C C NNP cord-267475-6f4h3cck 1032 46 / / SYM cord-267475-6f4h3cck 1032 47 EBPa EBPa NNS cord-267475-6f4h3cck 1032 48 ) ) -RRB- cord-267475-6f4h3cck 1032 49 , , , cord-267475-6f4h3cck 1032 50 in in IN cord-267475-6f4h3cck 1032 51 acute acute JJ cord-267475-6f4h3cck 1032 52 myeloid myeloid NN cord-267475-6f4h3cck 1032 53 leukemia leukemia NN cord-267475-6f4h3cck 1032 54 Mammalian mammalian JJ cord-267475-6f4h3cck 1032 55 cells cell NNS cord-267475-6f4h3cck 1032 56 express express VBP cord-267475-6f4h3cck 1032 57 two two CD cord-267475-6f4h3cck 1032 58 differently differently RB cord-267475-6f4h3cck 1032 59 localized localize VBN cord-267475-6f4h3cck 1032 60 Bag-1 Bag-1 NNP cord-267475-6f4h3cck 1032 61 isoforms isoform NNS cord-267475-6f4h3cck 1032 62 generated generate VBN cord-267475-6f4h3cck 1032 63 by by IN cord-267475-6f4h3cck 1032 64 alternative alternative JJ cord-267475-6f4h3cck 1032 65 translation translation NN cord-267475-6f4h3cck 1032 66 initiation initiation NN cord-267475-6f4h3cck 1032 67 Spliced splice VBN cord-267475-6f4h3cck 1032 68 and and CC cord-267475-6f4h3cck 1032 69 prematurely prematurely RB cord-267475-6f4h3cck 1032 70 polyadenylated polyadenylate VBN cord-267475-6f4h3cck 1032 71 Jaagsiekte Jaagsiekte NNP cord-267475-6f4h3cck 1032 72 sheep sheep NN cord-267475-6f4h3cck 1032 73 retrovirus retrovirus NN cord-267475-6f4h3cck 1032 74 - - HYPH cord-267475-6f4h3cck 1032 75 specific specific JJ cord-267475-6f4h3cck 1032 76 RNAs rna NNS cord-267475-6f4h3cck 1032 77 from from IN cord-267475-6f4h3cck 1032 78 infected infected JJ cord-267475-6f4h3cck 1032 79 or or CC cord-267475-6f4h3cck 1032 80 transfected transfecte VBN cord-267475-6f4h3cck 1032 81 cells cell NNS cord-267475-6f4h3cck 1033 1 Ribosomal Ribosomal NNP cord-267475-6f4h3cck 1033 2 pausing pause VBG cord-267475-6f4h3cck 1033 3 and and CC cord-267475-6f4h3cck 1033 4 scanning scanning NN cord-267475-6f4h3cck 1033 5 arrest arrest NN cord-267475-6f4h3cck 1033 6 as as IN cord-267475-6f4h3cck 1033 7 mechanisms mechanism NNS cord-267475-6f4h3cck 1033 8 of of IN cord-267475-6f4h3cck 1033 9 translational translational JJ cord-267475-6f4h3cck 1033 10 regulation regulation NN cord-267475-6f4h3cck 1033 11 from from IN cord-267475-6f4h3cck 1033 12 cap cap NN cord-267475-6f4h3cck 1033 13 - - HYPH cord-267475-6f4h3cck 1033 14 distal distal JJ cord-267475-6f4h3cck 1033 15 iron iron NN cord-267475-6f4h3cck 1033 16 - - HYPH cord-267475-6f4h3cck 1033 17 responsive responsive JJ cord-267475-6f4h3cck 1033 18 elements element NNS cord-267475-6f4h3cck 1033 19 HCC-2 HCC-2 NNP cord-267475-6f4h3cck 1033 20 , , , cord-267475-6f4h3cck 1033 21 a a DT cord-267475-6f4h3cck 1033 22 human human JJ cord-267475-6f4h3cck 1033 23 chemokine chemokine NN cord-267475-6f4h3cck 1033 24 : : : cord-267475-6f4h3cck 1033 25 gene gene NN cord-267475-6f4h3cck 1033 26 structure structure NN cord-267475-6f4h3cck 1033 27 , , , cord-267475-6f4h3cck 1033 28 expression expression NN cord-267475-6f4h3cck 1033 29 pattern pattern NN cord-267475-6f4h3cck 1033 30 , , , cord-267475-6f4h3cck 1033 31 and and CC cord-267475-6f4h3cck 1033 32 biological biological JJ cord-267475-6f4h3cck 1033 33 activity activity NN cord-267475-6f4h3cck 1034 1 A a DT cord-267475-6f4h3cck 1034 2 plant plant NN cord-267475-6f4h3cck 1034 3 viral viral JJ cord-267475-6f4h3cck 1034 4 " " `` cord-267475-6f4h3cck 1034 5 reinitiation reinitiation NN cord-267475-6f4h3cck 1034 6 " " '' cord-267475-6f4h3cck 1034 7 factor factor NN cord-267475-6f4h3cck 1034 8 interacts interact VBZ cord-267475-6f4h3cck 1034 9 with with IN cord-267475-6f4h3cck 1034 10 the the DT cord-267475-6f4h3cck 1034 11 host host NN cord-267475-6f4h3cck 1034 12 translational translational JJ cord-267475-6f4h3cck 1034 13 machinery machinery NN cord-267475-6f4h3cck 1034 14 Genetic genetic JJ cord-267475-6f4h3cck 1034 15 manipulation manipulation NN cord-267475-6f4h3cck 1034 16 of of IN cord-267475-6f4h3cck 1034 17 arterivirus arterivirus NNP cord-267475-6f4h3cck 1034 18 alternative alternative NNP cord-267475-6f4h3cck 1034 19 mRNA mRNA NNP cord-267475-6f4h3cck 1034 20 leader leader NN cord-267475-6f4h3cck 1034 21 - - HYPH cord-267475-6f4h3cck 1034 22 body body NN cord-267475-6f4h3cck 1034 23 junction junction NN cord-267475-6f4h3cck 1034 24 sites site NNS cord-267475-6f4h3cck 1034 25 reveals reveal VBZ cord-267475-6f4h3cck 1034 26 tight tight JJ cord-267475-6f4h3cck 1034 27 regulation regulation NN cord-267475-6f4h3cck 1034 28 of of IN cord-267475-6f4h3cck 1034 29 structural structural JJ cord-267475-6f4h3cck 1034 30 protein protein NN cord-267475-6f4h3cck 1034 31 expression expression NN cord-267475-6f4h3cck 1035 1 The the DT cord-267475-6f4h3cck 1035 2 size size NN cord-267475-6f4h3cck 1035 3 of of IN cord-267475-6f4h3cck 1035 4 Rous rous JJ cord-267475-6f4h3cck 1035 5 sarcoma sarcoma NN cord-267475-6f4h3cck 1035 6 virus virus NN cord-267475-6f4h3cck 1035 7 mRNAs mrnas XX cord-267475-6f4h3cck 1035 8 active active JJ cord-267475-6f4h3cck 1035 9 in in IN cord-267475-6f4h3cck 1035 10 cell cell NN cord-267475-6f4h3cck 1035 11 - - HYPH cord-267475-6f4h3cck 1035 12 free free JJ cord-267475-6f4h3cck 1035 13 translation translation NN cord-267475-6f4h3cck 1036 1 Starved starved JJ cord-267475-6f4h3cck 1036 2 Saccharomyces Saccharomyces NNP cord-267475-6f4h3cck 1036 3 cerevisiae cerevisiae NN cord-267475-6f4h3cck 1036 4 cells cell NNS cord-267475-6f4h3cck 1036 5 have have VBP cord-267475-6f4h3cck 1036 6 the the DT cord-267475-6f4h3cck 1036 7 capacity capacity NN cord-267475-6f4h3cck 1036 8 to to TO cord-267475-6f4h3cck 1036 9 support support VB cord-267475-6f4h3cck 1036 10 internal internal JJ cord-267475-6f4h3cck 1036 11 initiation initiation NN cord-267475-6f4h3cck 1036 12 of of IN cord-267475-6f4h3cck 1036 13 translation translation NN cord-267475-6f4h3cck 1036 14 Effect effect NN cord-267475-6f4h3cck 1036 15 of of IN cord-267475-6f4h3cck 1036 16 upstream upstream JJ cord-267475-6f4h3cck 1036 17 reading reading NN cord-267475-6f4h3cck 1036 18 frames frame NNS cord-267475-6f4h3cck 1036 19 on on IN cord-267475-6f4h3cck 1036 20 translation translation NN cord-267475-6f4h3cck 1036 21 efficiency efficiency NN cord-267475-6f4h3cck 1036 22 in in IN cord-267475-6f4h3cck 1036 23 simian simian JJ cord-267475-6f4h3cck 1036 24 virus virus NN cord-267475-6f4h3cck 1036 25 40 40 CD cord-267475-6f4h3cck 1036 26 recombinants recombinant NNS cord-267475-6f4h3cck 1036 27 Promoter Promoter NNP cord-267475-6f4h3cck 1036 28 choice choice NN cord-267475-6f4h3cck 1036 29 influences influence VBZ cord-267475-6f4h3cck 1036 30 alternative alternative JJ cord-267475-6f4h3cck 1036 31 splicing splicing NN cord-267475-6f4h3cck 1036 32 and and CC cord-267475-6f4h3cck 1036 33 determines determine VBZ cord-267475-6f4h3cck 1036 34 the the DT cord-267475-6f4h3cck 1036 35 balance balance NN cord-267475-6f4h3cck 1036 36 of of IN cord-267475-6f4h3cck 1036 37 isoforms isoform NNS cord-267475-6f4h3cck 1036 38 expressed express VBN cord-267475-6f4h3cck 1036 39 from from IN cord-267475-6f4h3cck 1036 40 the the DT cord-267475-6f4h3cck 1036 41 mouse mouse NN cord-267475-6f4h3cck 1036 42 bcl bcl NNP cord-267475-6f4h3cck 1036 43 - - HYPH cord-267475-6f4h3cck 1036 44 X X NNP cord-267475-6f4h3cck 1036 45 gene gene NN cord-267475-6f4h3cck 1036 46 Functional functional JJ cord-267475-6f4h3cck 1036 47 organization organization NN cord-267475-6f4h3cck 1036 48 of of IN cord-267475-6f4h3cck 1036 49 the the DT cord-267475-6f4h3cck 1036 50 human human JJ cord-267475-6f4h3cck 1036 51 uncoupling uncoupling NN cord-267475-6f4h3cck 1036 52 protein-2 protein-2 POS cord-267475-6f4h3cck 1036 53 gene gene NN cord-267475-6f4h3cck 1036 54 , , , cord-267475-6f4h3cck 1036 55 and and CC cord-267475-6f4h3cck 1036 56 juxtaposition juxtaposition NN cord-267475-6f4h3cck 1036 57 to to IN cord-267475-6f4h3cck 1036 58 the the DT cord-267475-6f4h3cck 1036 59 uncoupling uncouple VBG cord-267475-6f4h3cck 1036 60 protein-3 protein-3 NNP cord-267475-6f4h3cck 1036 61 gene gene NN cord-267475-6f4h3cck 1036 62 Uncoupling uncouple VBG cord-267475-6f4h3cck 1036 63 protein protein NN cord-267475-6f4h3cck 1036 64 2 2 CD cord-267475-6f4h3cck 1036 65 , , , cord-267475-6f4h3cck 1036 66 in in IN cord-267475-6f4h3cck 1036 67 vivo vivo NN cord-267475-6f4h3cck 1036 68 distribution distribution NN cord-267475-6f4h3cck 1036 69 , , , cord-267475-6f4h3cck 1036 70 induction induction NN cord-267475-6f4h3cck 1036 71 upon upon IN cord-267475-6f4h3cck 1036 72 oxidative oxidative JJ cord-267475-6f4h3cck 1036 73 stress stress NN cord-267475-6f4h3cck 1036 74 , , , cord-267475-6f4h3cck 1036 75 and and CC cord-267475-6f4h3cck 1036 76 evidence evidence NN cord-267475-6f4h3cck 1036 77 for for IN cord-267475-6f4h3cck 1036 78 translational translational JJ cord-267475-6f4h3cck 1036 79 regulation regulation NN cord-267475-6f4h3cck 1037 1 The the DT cord-267475-6f4h3cck 1037 2 exon exon NN cord-267475-6f4h3cck 1037 3 structure structure NN cord-267475-6f4h3cck 1037 4 of of IN cord-267475-6f4h3cck 1037 5 the the DT cord-267475-6f4h3cck 1037 6 mouse mouse NN cord-267475-6f4h3cck 1037 7 a2(IX a2(ix ADD cord-267475-6f4h3cck 1037 8 ) ) -RRB- cord-267475-6f4h3cck 1038 1 collagen collagen NNP cord-267475-6f4h3cck 1038 2 gene gene NN cord-267475-6f4h3cck 1038 3 shows show VBZ cord-267475-6f4h3cck 1038 4 unexpected unexpected JJ cord-267475-6f4h3cck 1038 5 divergence divergence NN cord-267475-6f4h3cck 1038 6 from from IN cord-267475-6f4h3cck 1038 7 the the DT cord-267475-6f4h3cck 1038 8 chick chick NN cord-267475-6f4h3cck 1038 9 gene gene NN cord-267475-6f4h3cck 1038 10 Identification Identification NNP cord-267475-6f4h3cck 1038 11 of of IN cord-267475-6f4h3cck 1038 12 the the DT cord-267475-6f4h3cck 1038 13 subgenomic subgenomic NNP cord-267475-6f4h3cck 1038 14 mRNAs mRNAs NNPS cord-267475-6f4h3cck 1038 15 that that WDT cord-267475-6f4h3cck 1038 16 encode encode VBP cord-267475-6f4h3cck 1038 17 6-kDa 6-kDa NNP cord-267475-6f4h3cck 1038 18 movement movement NN cord-267475-6f4h3cck 1038 19 protein protein NN cord-267475-6f4h3cck 1038 20 and and CC cord-267475-6f4h3cck 1038 21 Hsp70 Hsp70 NNP cord-267475-6f4h3cck 1038 22 homolog homolog NN cord-267475-6f4h3cck 1038 23 of of IN cord-267475-6f4h3cck 1039 1 Beet beet NN cord-267475-6f4h3cck 1039 2 yellows yellow NNS cord-267475-6f4h3cck 1039 3 virus virus NN cord-267475-6f4h3cck 1039 4 A a DT cord-267475-6f4h3cck 1039 5 reassessment reassessment NN cord-267475-6f4h3cck 1039 6 of of IN cord-267475-6f4h3cck 1039 7 the the DT cord-267475-6f4h3cck 1039 8 translation translation NN cord-267475-6f4h3cck 1039 9 initiation initiation NN cord-267475-6f4h3cck 1039 10 codon codon NN cord-267475-6f4h3cck 1039 11 in in IN cord-267475-6f4h3cck 1039 12 vertebrates vertebrate NNS cord-267475-6f4h3cck 1039 13 Characterization characterization NN cord-267475-6f4h3cck 1039 14 of of IN cord-267475-6f4h3cck 1039 15 human human JJ cord-267475-6f4h3cck 1039 16 mucin mucin NN cord-267475-6f4h3cck 1039 17 gene gene NN cord-267475-6f4h3cck 1039 18 MUC4 MUC4 NNP cord-267475-6f4h3cck 1039 19 promoter promoter NN cord-267475-6f4h3cck 1039 20 p76 p76 NN cord-267475-6f4h3cck 1039 21 MDM2 MDM2 NNPS cord-267475-6f4h3cck 1039 22 inhibits inhibit VBZ cord-267475-6f4h3cck 1039 23 the the DT cord-267475-6f4h3cck 1039 24 ability ability NN cord-267475-6f4h3cck 1039 25 of of IN cord-267475-6f4h3cck 1039 26 p90 p90 NNP cord-267475-6f4h3cck 1039 27 MDM2 MDM2 NNP cord-267475-6f4h3cck 1039 28 to to TO cord-267475-6f4h3cck 1039 29 destabilize destabilize VB cord-267475-6f4h3cck 1039 30 p53 p53 NN cord-267475-6f4h3cck 1039 31 Analysis Analysis NNP cord-267475-6f4h3cck 1039 32 of of IN cord-267475-6f4h3cck 1039 33 oligonucleotide oligonucleotide JJ cord-267475-6f4h3cck 1039 34 AUG AUG NNP cord-267475-6f4h3cck 1039 35 start start NN cord-267475-6f4h3cck 1039 36 codon codon NN cord-267475-6f4h3cck 1039 37 context context NN cord-267475-6f4h3cck 1039 38 in in IN cord-267475-6f4h3cck 1039 39 eukariotic eukariotic NN cord-267475-6f4h3cck 1039 40 mRNAs mrnas CD cord-267475-6f4h3cck 1040 1 Structural structural JJ cord-267475-6f4h3cck 1040 2 and and CC cord-267475-6f4h3cck 1040 3 functional functional JJ cord-267475-6f4h3cck 1040 4 features feature NNS cord-267475-6f4h3cck 1040 5 of of IN cord-267475-6f4h3cck 1040 6 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 1040 7 mRNA mRNA NNP cord-267475-6f4h3cck 1040 8 untranslated untranslated JJ cord-267475-6f4h3cck 1040 9 regions region NNS cord-267475-6f4h3cck 1040 10 Molecular Molecular NNP cord-267475-6f4h3cck 1040 11 mechanisms mechanism NNS cord-267475-6f4h3cck 1040 12 of of IN cord-267475-6f4h3cck 1040 13 translation translation NN cord-267475-6f4h3cck 1040 14 initiation initiation NN cord-267475-6f4h3cck 1040 15 in in IN cord-267475-6f4h3cck 1040 16 eukaryotes eukaryote NNS cord-267475-6f4h3cck 1041 1 Human human JJ cord-267475-6f4h3cck 1041 2 myeloid myeloid NN cord-267475-6f4h3cck 1041 3 zinc zinc NN cord-267475-6f4h3cck 1041 4 finger finger NN cord-267475-6f4h3cck 1041 5 gene gene NN cord-267475-6f4h3cck 1041 6 MZF MZF NNP cord-267475-6f4h3cck 1041 7 produces produce VBZ cord-267475-6f4h3cck 1041 8 multiple multiple JJ cord-267475-6f4h3cck 1041 9 transcripts transcript NNS cord-267475-6f4h3cck 1041 10 and and CC cord-267475-6f4h3cck 1041 11 encodes encode VBZ cord-267475-6f4h3cck 1041 12 a a DT cord-267475-6f4h3cck 1041 13 SCAN scan JJ cord-267475-6f4h3cck 1041 14 box box NN cord-267475-6f4h3cck 1041 15 protein protein NN cord-267475-6f4h3cck 1041 16 Systematic systematic JJ cord-267475-6f4h3cck 1041 17 movement movement NN cord-267475-6f4h3cck 1041 18 of of IN cord-267475-6f4h3cck 1041 19 an an DT cord-267475-6f4h3cck 1041 20 RNA RNA NNP cord-267475-6f4h3cck 1041 21 plant plant NN cord-267475-6f4h3cck 1041 22 virus virus NN cord-267475-6f4h3cck 1041 23 determined determine VBN cord-267475-6f4h3cck 1041 24 by by IN cord-267475-6f4h3cck 1041 25 a a DT cord-267475-6f4h3cck 1041 26 point point NN cord-267475-6f4h3cck 1041 27 substitution substitution NN cord-267475-6f4h3cck 1041 28 in in IN cord-267475-6f4h3cck 1041 29 a a DT cord-267475-6f4h3cck 1041 30 5 5 CD cord-267475-6f4h3cck 1041 31 0 0 CD cord-267475-6f4h3cck 1041 32 leader leader NN cord-267475-6f4h3cck 1041 33 sequence sequence NN cord-267475-6f4h3cck 1041 34 Coupled couple VBN cord-267475-6f4h3cck 1041 35 transcriptional transcriptional JJ cord-267475-6f4h3cck 1041 36 and and CC cord-267475-6f4h3cck 1041 37 translational translational JJ cord-267475-6f4h3cck 1041 38 control control NN cord-267475-6f4h3cck 1041 39 of of IN cord-267475-6f4h3cck 1041 40 cyclin cyclin NN cord-267475-6f4h3cck 1041 41 - - HYPH cord-267475-6f4h3cck 1041 42 dependent dependent JJ cord-267475-6f4h3cck 1041 43 kinase kinase NN cord-267475-6f4h3cck 1041 44 inhibitor inhibitor NN cord-267475-6f4h3cck 1042 1 p18 p18 CD cord-267475-6f4h3cck 1043 1 INK4c ink4c NN cord-267475-6f4h3cck 1043 2 expression expression NN cord-267475-6f4h3cck 1043 3 during during IN cord-267475-6f4h3cck 1043 4 myogenesis myogenesis NN cord-267475-6f4h3cck 1043 5 Hepatocyte Hepatocyte NNP cord-267475-6f4h3cck 1043 6 - - HYPH cord-267475-6f4h3cck 1043 7 nuclear nuclear JJ cord-267475-6f4h3cck 1043 8 factor factor NN cord-267475-6f4h3cck 1044 1 3b 3b NNP cord-267475-6f4h3cck 1044 2 gene gene NN cord-267475-6f4h3cck 1044 3 transcripts transcript NNS cord-267475-6f4h3cck 1044 4 generate generate VBP cord-267475-6f4h3cck 1044 5 protein protein NN cord-267475-6f4h3cck 1044 6 isoforms isoform NNS cord-267475-6f4h3cck 1044 7 with with IN cord-267475-6f4h3cck 1044 8 different different JJ cord-267475-6f4h3cck 1044 9 transactivation transactivation NN cord-267475-6f4h3cck 1044 10 properties property NNS cord-267475-6f4h3cck 1044 11 on on IN cord-267475-6f4h3cck 1044 12 the the DT cord-267475-6f4h3cck 1044 13 glucagon glucagon NN cord-267475-6f4h3cck 1044 14 gene gene NN cord-267475-6f4h3cck 1044 15 Internal internal JJ cord-267475-6f4h3cck 1044 16 initiation initiation NN cord-267475-6f4h3cck 1044 17 of of IN cord-267475-6f4h3cck 1044 18 translation translation NN cord-267475-6f4h3cck 1044 19 of of IN cord-267475-6f4h3cck 1044 20 five five CD cord-267475-6f4h3cck 1044 21 dendritically dendritically RB cord-267475-6f4h3cck 1044 22 localized localize VBN cord-267475-6f4h3cck 1044 23 neuronal neuronal JJ cord-267475-6f4h3cck 1044 24 mRNAs mrnas CD cord-267475-6f4h3cck 1045 1 The the DT cord-267475-6f4h3cck 1045 2 amphiregulin amphiregulin NN cord-267475-6f4h3cck 1045 3 gene gene NN cord-267475-6f4h3cck 1045 4 encodes encode VBZ cord-267475-6f4h3cck 1045 5 a a DT cord-267475-6f4h3cck 1045 6 novel novel JJ cord-267475-6f4h3cck 1045 7 epidermal epidermal JJ cord-267475-6f4h3cck 1045 8 growth growth NN cord-267475-6f4h3cck 1045 9 factor factor NN cord-267475-6f4h3cck 1045 10 - - HYPH cord-267475-6f4h3cck 1045 11 related relate VBN cord-267475-6f4h3cck 1045 12 protein protein NN cord-267475-6f4h3cck 1045 13 with with IN cord-267475-6f4h3cck 1045 14 tumor tumor NN cord-267475-6f4h3cck 1045 15 - - HYPH cord-267475-6f4h3cck 1045 16 inhibitory inhibitory JJ cord-267475-6f4h3cck 1045 17 activity activity NN cord-267475-6f4h3cck 1045 18 Characterization characterization NN cord-267475-6f4h3cck 1045 19 of of IN cord-267475-6f4h3cck 1045 20 hypersensitive hypersensitive JJ cord-267475-6f4h3cck 1045 21 sites site NNS cord-267475-6f4h3cck 1045 22 , , , cord-267475-6f4h3cck 1045 23 protein protein NN cord-267475-6f4h3cck 1045 24 - - HYPH cord-267475-6f4h3cck 1045 25 binding bind VBG cord-267475-6f4h3cck 1045 26 motifs motif NNS cord-267475-6f4h3cck 1045 27 , , , cord-267475-6f4h3cck 1045 28 and and CC cord-267475-6f4h3cck 1045 29 regulatory regulatory JJ cord-267475-6f4h3cck 1045 30 elements element NNS cord-267475-6f4h3cck 1045 31 in in IN cord-267475-6f4h3cck 1045 32 both both DT cord-267475-6f4h3cck 1045 33 promoters promoter NNS cord-267475-6f4h3cck 1045 34 of of IN cord-267475-6f4h3cck 1045 35 the the DT cord-267475-6f4h3cck 1045 36 mouse mouse NN cord-267475-6f4h3cck 1045 37 porphobilinogen porphobilinogen NNP cord-267475-6f4h3cck 1045 38 deaminase deaminase NNP cord-267475-6f4h3cck 1045 39 gene gene NN cord-267475-6f4h3cck 1045 40 Identification Identification NNP cord-267475-6f4h3cck 1045 41 of of IN cord-267475-6f4h3cck 1045 42 a a DT cord-267475-6f4h3cck 1045 43 sequence sequence NN cord-267475-6f4h3cck 1045 44 in in IN cord-267475-6f4h3cck 1045 45 the the DT cord-267475-6f4h3cck 1045 46 unique unique JJ cord-267475-6f4h3cck 1045 47 5 5 CD cord-267475-6f4h3cck 1045 48 0 0 CD cord-267475-6f4h3cck 1045 49 open open JJ cord-267475-6f4h3cck 1045 50 reading reading NN cord-267475-6f4h3cck 1045 51 frame frame NN cord-267475-6f4h3cck 1045 52 of of IN cord-267475-6f4h3cck 1045 53 the the DT cord-267475-6f4h3cck 1045 54 gene gene NN cord-267475-6f4h3cck 1045 55 encoding encode VBG cord-267475-6f4h3cck 1045 56 glycosylated glycosylated JJ cord-267475-6f4h3cck 1045 57 gag gag NN cord-267475-6f4h3cck 1045 58 which which WDT cord-267475-6f4h3cck 1045 59 influences influence VBZ cord-267475-6f4h3cck 1045 60 the the DT cord-267475-6f4h3cck 1045 61 incubation incubation NN cord-267475-6f4h3cck 1045 62 period period NN cord-267475-6f4h3cck 1045 63 of of IN cord-267475-6f4h3cck 1045 64 neurodegenerative neurodegenerative JJ cord-267475-6f4h3cck 1045 65 disease disease NN cord-267475-6f4h3cck 1045 66 induced induce VBN cord-267475-6f4h3cck 1045 67 by by IN cord-267475-6f4h3cck 1045 68 a a DT cord-267475-6f4h3cck 1045 69 murine murine JJ cord-267475-6f4h3cck 1045 70 retrovirus retrovirus NN cord-267475-6f4h3cck 1046 1 The the DT cord-267475-6f4h3cck 1046 2 glycosylated glycosylated JJ cord-267475-6f4h3cck 1046 3 gag gag NN cord-267475-6f4h3cck 1046 4 protein protein NN cord-267475-6f4h3cck 1046 5 of of IN cord-267475-6f4h3cck 1046 6 MuLV MuLV NNP cord-267475-6f4h3cck 1046 7 is be VBZ cord-267475-6f4h3cck 1046 8 a a DT cord-267475-6f4h3cck 1046 9 determinant determinant NN cord-267475-6f4h3cck 1046 10 of of IN cord-267475-6f4h3cck 1046 11 neuroinvasiveness neuroinvasiveness NN cord-267475-6f4h3cck 1046 12 : : : cord-267475-6f4h3cck 1046 13 analysis analysis NN cord-267475-6f4h3cck 1046 14 of of IN cord-267475-6f4h3cck 1046 15 second second JJ cord-267475-6f4h3cck 1046 16 site site NN cord-267475-6f4h3cck 1046 17 revertants revertant NNS cord-267475-6f4h3cck 1046 18 of of IN cord-267475-6f4h3cck 1046 19 a a DT cord-267475-6f4h3cck 1046 20 mutant mutant JJ cord-267475-6f4h3cck 1046 21 MuLV MuLV NNP cord-267475-6f4h3cck 1046 22 virus virus NN cord-267475-6f4h3cck 1046 23 lacking lack VBG cord-267475-6f4h3cck 1046 24 expression expression NN cord-267475-6f4h3cck 1046 25 of of IN cord-267475-6f4h3cck 1046 26 this this DT cord-267475-6f4h3cck 1046 27 protein protein NN cord-267475-6f4h3cck 1046 28 An an DT cord-267475-6f4h3cck 1046 29 alternative alternative JJ cord-267475-6f4h3cck 1046 30 open open JJ cord-267475-6f4h3cck 1046 31 reading reading NN cord-267475-6f4h3cck 1046 32 frame frame NN cord-267475-6f4h3cck 1046 33 of of IN cord-267475-6f4h3cck 1046 34 the the DT cord-267475-6f4h3cck 1046 35 human human JJ cord-267475-6f4h3cck 1046 36 macrophage macrophage NN cord-267475-6f4h3cck 1046 37 colony colony NN cord-267475-6f4h3cck 1046 38 - - HYPH cord-267475-6f4h3cck 1046 39 stimulating stimulate VBG cord-267475-6f4h3cck 1046 40 factor factor NN cord-267475-6f4h3cck 1046 41 gene gene NN cord-267475-6f4h3cck 1046 42 is be VBZ cord-267475-6f4h3cck 1046 43 independently independently RB cord-267475-6f4h3cck 1046 44 translated translate VBN cord-267475-6f4h3cck 1046 45 and and CC cord-267475-6f4h3cck 1046 46 codes code NNS cord-267475-6f4h3cck 1046 47 for for IN cord-267475-6f4h3cck 1046 48 an an DT cord-267475-6f4h3cck 1046 49 antigenic antigenic JJ cord-267475-6f4h3cck 1046 50 peptide peptide NN cord-267475-6f4h3cck 1046 51 of of IN cord-267475-6f4h3cck 1046 52 14 14 CD cord-267475-6f4h3cck 1046 53 amino amino JJ cord-267475-6f4h3cck 1046 54 acids acid NNS cord-267475-6f4h3cck 1046 55 recognized recognize VBN cord-267475-6f4h3cck 1046 56 by by IN cord-267475-6f4h3cck 1046 57 tumorinfiltrating tumorinfiltrate VBG cord-267475-6f4h3cck 1046 58 CD8 CD8 NNP cord-267475-6f4h3cck 1046 59 T T NNP cord-267475-6f4h3cck 1046 60 lymphocytes lymphocyte NNS cord-267475-6f4h3cck 1047 1 Introducing introduce VBG cord-267475-6f4h3cck 1047 2 RefSeq RefSeq NNP cord-267475-6f4h3cck 1047 3 and and CC cord-267475-6f4h3cck 1047 4 LocusLink LocusLink NNP cord-267475-6f4h3cck 1047 5 : : : cord-267475-6f4h3cck 1047 6 curated curate VBN cord-267475-6f4h3cck 1047 7 human human JJ cord-267475-6f4h3cck 1047 8 genome genome NN cord-267475-6f4h3cck 1047 9 resources resource NNS cord-267475-6f4h3cck 1047 10 at at IN cord-267475-6f4h3cck 1047 11 the the DT cord-267475-6f4h3cck 1047 12 NCBI NCBI NNP cord-267475-6f4h3cck 1047 13 Rat Rat NNP cord-267475-6f4h3cck 1047 14 phospholipid phospholipid NN cord-267475-6f4h3cck 1047 15 - - HYPH cord-267475-6f4h3cck 1047 16 hydroperoxide hydroperoxide NN cord-267475-6f4h3cck 1047 17 glutathione glutathione NN cord-267475-6f4h3cck 1047 18 peroxidase peroxidase NN cord-267475-6f4h3cck 1047 19 . . . cord-267475-6f4h3cck 1048 1 cDNA cdna NN cord-267475-6f4h3cck 1048 2 cloning cloning NN cord-267475-6f4h3cck 1048 3 and and CC cord-267475-6f4h3cck 1048 4 identification identification NN cord-267475-6f4h3cck 1048 5 of of IN cord-267475-6f4h3cck 1048 6 multiple multiple JJ cord-267475-6f4h3cck 1048 7 transcription transcription NN cord-267475-6f4h3cck 1048 8 and and CC cord-267475-6f4h3cck 1048 9 translation translation NN cord-267475-6f4h3cck 1048 10 start start NN cord-267475-6f4h3cck 1048 11 sites site NNS cord-267475-6f4h3cck 1048 12 Mechanisms mechanism NNS cord-267475-6f4h3cck 1048 13 of of IN cord-267475-6f4h3cck 1048 14 loss loss NN cord-267475-6f4h3cck 1048 15 of of IN cord-267475-6f4h3cck 1048 16 foreign foreign JJ cord-267475-6f4h3cck 1048 17 gene gene NN cord-267475-6f4h3cck 1048 18 expression expression NN cord-267475-6f4h3cck 1048 19 in in IN cord-267475-6f4h3cck 1048 20 recombinant recombinant JJ cord-267475-6f4h3cck 1048 21 vesicular vesicular JJ cord-267475-6f4h3cck 1048 22 stomatitis stomatitis NN cord-267475-6f4h3cck 1048 23 viruses virus NNS cord-267475-6f4h3cck 1049 1 In in IN cord-267475-6f4h3cck 1049 2 vitro vitro FW cord-267475-6f4h3cck 1049 3 translation translation NN cord-267475-6f4h3cck 1049 4 of of IN cord-267475-6f4h3cck 1049 5 the the DT cord-267475-6f4h3cck 1049 6 upstream upstream JJ cord-267475-6f4h3cck 1049 7 open open JJ cord-267475-6f4h3cck 1049 8 reading reading NN cord-267475-6f4h3cck 1049 9 frame frame NN cord-267475-6f4h3cck 1049 10 in in IN cord-267475-6f4h3cck 1049 11 the the DT cord-267475-6f4h3cck 1049 12 mammalian mammalian JJ cord-267475-6f4h3cck 1049 13 mRNA mrna NN cord-267475-6f4h3cck 1049 14 encoding encode VBG cord-267475-6f4h3cck 1049 15 S S NNP cord-267475-6f4h3cck 1049 16 - - HYPH cord-267475-6f4h3cck 1049 17 adenosylmethionine adenosylmethionine NN cord-267475-6f4h3cck 1049 18 decarboxylase decarboxylase NN cord-267475-6f4h3cck 1050 1 The the DT cord-267475-6f4h3cck 1050 2 5 5 CD cord-267475-6f4h3cck 1050 3 0 0 CD cord-267475-6f4h3cck 1050 4 untranslated untranslated JJ cord-267475-6f4h3cck 1050 5 sequence sequence NN cord-267475-6f4h3cck 1050 6 of of IN cord-267475-6f4h3cck 1050 7 the the DT cord-267475-6f4h3cck 1050 8 c c NNP cord-267475-6f4h3cck 1050 9 - - HYPH cord-267475-6f4h3cck 1050 10 sis sis NNP cord-267475-6f4h3cck 1050 11 platelet platelet NN cord-267475-6f4h3cck 1050 12 - - HYPH cord-267475-6f4h3cck 1050 13 derived derive VBN cord-267475-6f4h3cck 1050 14 growth growth NN cord-267475-6f4h3cck 1050 15 factor factor NN cord-267475-6f4h3cck 1050 16 2 2 CD cord-267475-6f4h3cck 1050 17 transcript transcript NN cord-267475-6f4h3cck 1050 18 is be VBZ cord-267475-6f4h3cck 1050 19 a a DT cord-267475-6f4h3cck 1050 20 potent potent JJ cord-267475-6f4h3cck 1050 21 translational translational JJ cord-267475-6f4h3cck 1050 22 inhibitor inhibitor NN cord-267475-6f4h3cck 1051 1 A a DT cord-267475-6f4h3cck 1051 2 single single JJ cord-267475-6f4h3cck 1051 3 gene gene NN cord-267475-6f4h3cck 1051 4 encodes encode VBZ cord-267475-6f4h3cck 1051 5 two two CD cord-267475-6f4h3cck 1051 6 isoforms isoform NNS cord-267475-6f4h3cck 1051 7 of of IN cord-267475-6f4h3cck 1051 8 the the DT cord-267475-6f4h3cck 1051 9 p70 p70 CD cord-267475-6f4h3cck 1051 10 S6 S6 NNP cord-267475-6f4h3cck 1051 11 kinase kinase NN cord-267475-6f4h3cck 1051 12 : : : cord-267475-6f4h3cck 1051 13 activation activation NN cord-267475-6f4h3cck 1051 14 upon upon IN cord-267475-6f4h3cck 1051 15 mitogenic mitogenic NNP cord-267475-6f4h3cck 1051 16 stimulation stimulation NN cord-267475-6f4h3cck 1052 1 Posttranscriptional Posttranscriptional NNP cord-267475-6f4h3cck 1052 2 mRNA mRNA NNP cord-267475-6f4h3cck 1052 3 processing process VBG cord-267475-6f4h3cck 1052 4 as as IN cord-267475-6f4h3cck 1052 5 a a DT cord-267475-6f4h3cck 1052 6 mechanism mechanism NN cord-267475-6f4h3cck 1052 7 for for IN cord-267475-6f4h3cck 1052 8 regulation regulation NN cord-267475-6f4h3cck 1052 9 of of IN cord-267475-6f4h3cck 1052 10 human human NN cord-267475-6f4h3cck 1052 11 A a DT cord-267475-6f4h3cck 1052 12 1 1 CD cord-267475-6f4h3cck 1052 13 adenosine adenosine NN cord-267475-6f4h3cck 1052 14 receptor receptor NN cord-267475-6f4h3cck 1052 15 expression expression NN cord-267475-6f4h3cck 1052 16 Expression expression NN cord-267475-6f4h3cck 1052 17 of of IN cord-267475-6f4h3cck 1052 18 the the DT cord-267475-6f4h3cck 1052 19 smoothelin smoothelin NNP cord-267475-6f4h3cck 1052 20 gene gene NN cord-267475-6f4h3cck 1052 21 is be VBZ cord-267475-6f4h3cck 1052 22 mediated mediate VBN cord-267475-6f4h3cck 1052 23 by by IN cord-267475-6f4h3cck 1052 24 alternative alternative JJ cord-267475-6f4h3cck 1052 25 promoters promoter NNS cord-267475-6f4h3cck 1052 26 Mouse Mouse NNP cord-267475-6f4h3cck 1052 27 mammary mammary JJ cord-267475-6f4h3cck 1052 28 tumor tumor NN cord-267475-6f4h3cck 1052 29 virus virus NN cord-267475-6f4h3cck 1052 30 superantigen superantigen NN cord-267475-6f4h3cck 1052 31 expression expression NN cord-267475-6f4h3cck 1052 32 in in IN cord-267475-6f4h3cck 1052 33 B b NN cord-267475-6f4h3cck 1052 34 cells cell NNS cord-267475-6f4h3cck 1052 35 is be VBZ cord-267475-6f4h3cck 1052 36 regulated regulate VBN cord-267475-6f4h3cck 1052 37 by by IN cord-267475-6f4h3cck 1052 38 a a DT cord-267475-6f4h3cck 1052 39 central central JJ cord-267475-6f4h3cck 1052 40 enhancer enhancer NN cord-267475-6f4h3cck 1052 41 within within IN cord-267475-6f4h3cck 1052 42 the the DT cord-267475-6f4h3cck 1052 43 pol pol NN cord-267475-6f4h3cck 1052 44 gene gene NN cord-267475-6f4h3cck 1052 45 Non Non NNP cord-267475-6f4h3cck 1052 46 - - NNP cord-267475-6f4h3cck 1052 47 AUG AUG NNP cord-267475-6f4h3cck 1052 48 initiation initiation NN cord-267475-6f4h3cck 1052 49 of of IN cord-267475-6f4h3cck 1052 50 AGAMOUS AGAMOUS NNP cord-267475-6f4h3cck 1052 51 mRNA mRNA NNP cord-267475-6f4h3cck 1052 52 translation translation NN cord-267475-6f4h3cck 1052 53 in in IN cord-267475-6f4h3cck 1052 54 Arabidopsis Arabidopsis NNP cord-267475-6f4h3cck 1052 55 thaliana thaliana NN cord-267475-6f4h3cck 1053 1 Efficient efficient JJ cord-267475-6f4h3cck 1053 2 simultaneous simultaneous JJ cord-267475-6f4h3cck 1053 3 presentation presentation NN cord-267475-6f4h3cck 1053 4 of of IN cord-267475-6f4h3cck 1053 5 NY NY NNP cord-267475-6f4h3cck 1053 6 - - HYPH cord-267475-6f4h3cck 1053 7 ESO-1 ESO-1 NNP cord-267475-6f4h3cck 1053 8 / / SYM cord-267475-6f4h3cck 1053 9 LAGE-1 LAGE-1 NNP cord-267475-6f4h3cck 1053 10 primary primary NN cord-267475-6f4h3cck 1053 11 and and CC cord-267475-6f4h3cck 1053 12 nonprimary nonprimary JJ cord-267475-6f4h3cck 1053 13 open open JJ cord-267475-6f4h3cck 1053 14 reading read VBG cord-267475-6f4h3cck 1053 15 frame frame NN cord-267475-6f4h3cck 1053 16 - - HYPH cord-267475-6f4h3cck 1053 17 derived derive VBN cord-267475-6f4h3cck 1053 18 CTL CTL NNP cord-267475-6f4h3cck 1053 19 epitopes epitope NNS cord-267475-6f4h3cck 1053 20 in in IN cord-267475-6f4h3cck 1053 21 melanoma melanoma NN cord-267475-6f4h3cck 1053 22 Presence Presence NNP cord-267475-6f4h3cck 1053 23 of of IN cord-267475-6f4h3cck 1053 24 ATG ATG NNP cord-267475-6f4h3cck 1053 25 triplets triplet NNS cord-267475-6f4h3cck 1053 26 in in IN cord-267475-6f4h3cck 1053 27 5 5 CD cord-267475-6f4h3cck 1053 28 0 0 CD cord-267475-6f4h3cck 1053 29 untranslated untranslated JJ cord-267475-6f4h3cck 1053 30 regions region NNS cord-267475-6f4h3cck 1053 31 of of IN cord-267475-6f4h3cck 1053 32 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 1053 33 cDNAs cdna NNS cord-267475-6f4h3cck 1053 34 correlates correlate VBZ cord-267475-6f4h3cck 1053 35 with with IN cord-267475-6f4h3cck 1053 36 a a DT cord-267475-6f4h3cck 1053 37 ' ' `` cord-267475-6f4h3cck 1053 38 weak weak JJ cord-267475-6f4h3cck 1053 39 ' ' '' cord-267475-6f4h3cck 1053 40 context context NN cord-267475-6f4h3cck 1053 41 of of IN cord-267475-6f4h3cck 1053 42 the the DT cord-267475-6f4h3cck 1053 43 start start NN cord-267475-6f4h3cck 1054 1 codon codon NNP cord-267475-6f4h3cck 1054 2 A a DT cord-267475-6f4h3cck 1054 3 non non JJ cord-267475-6f4h3cck 1054 4 - - JJ cord-267475-6f4h3cck 1054 5 AUG aug NN cord-267475-6f4h3cck 1054 6 - - HYPH cord-267475-6f4h3cck 1054 7 defined define VBN cord-267475-6f4h3cck 1054 8 alternative alternative JJ cord-267475-6f4h3cck 1054 9 open open JJ cord-267475-6f4h3cck 1054 10 reading reading NN cord-267475-6f4h3cck 1054 11 frame frame NN cord-267475-6f4h3cck 1054 12 of of IN cord-267475-6f4h3cck 1054 13 the the DT cord-267475-6f4h3cck 1054 14 intestinal intestinal JJ cord-267475-6f4h3cck 1054 15 carboxyl carboxyl NN cord-267475-6f4h3cck 1054 16 esterase esterase NN cord-267475-6f4h3cck 1054 17 mRNA mRNA NNP cord-267475-6f4h3cck 1054 18 generates generate VBZ cord-267475-6f4h3cck 1054 19 an an DT cord-267475-6f4h3cck 1054 20 epitope epitope NN cord-267475-6f4h3cck 1054 21 recognized recognize VBN cord-267475-6f4h3cck 1054 22 by by IN cord-267475-6f4h3cck 1054 23 renal renal JJ cord-267475-6f4h3cck 1054 24 cell cell NN cord-267475-6f4h3cck 1054 25 carcinoma carcinoma NN cord-267475-6f4h3cck 1054 26 - - HYPH cord-267475-6f4h3cck 1054 27 reactive reactive JJ cord-267475-6f4h3cck 1054 28 tumor tumor NN cord-267475-6f4h3cck 1054 29 - - HYPH cord-267475-6f4h3cck 1054 30 infiltrating infiltrate VBG cord-267475-6f4h3cck 1054 31 lymphocytes lymphocyte NNS cord-267475-6f4h3cck 1054 32 in in IN cord-267475-6f4h3cck 1054 33 situ situ JJ cord-267475-6f4h3cck 1054 34 Identification identification NN cord-267475-6f4h3cck 1054 35 of of IN cord-267475-6f4h3cck 1054 36 BING-4 BING-4 NNP cord-267475-6f4h3cck 1054 37 cancer cancer NN cord-267475-6f4h3cck 1054 38 antigen antigen NN cord-267475-6f4h3cck 1054 39 translated translate VBN cord-267475-6f4h3cck 1054 40 from from IN cord-267475-6f4h3cck 1054 41 an an DT cord-267475-6f4h3cck 1054 42 alternative alternative JJ cord-267475-6f4h3cck 1054 43 open open JJ cord-267475-6f4h3cck 1054 44 reading reading NN cord-267475-6f4h3cck 1054 45 frame frame NN cord-267475-6f4h3cck 1054 46 of of IN cord-267475-6f4h3cck 1054 47 a a DT cord-267475-6f4h3cck 1054 48 gene gene NN cord-267475-6f4h3cck 1054 49 in in IN cord-267475-6f4h3cck 1054 50 the the DT cord-267475-6f4h3cck 1054 51 extended extended JJ cord-267475-6f4h3cck 1054 52 MHC MHC NNP cord-267475-6f4h3cck 1054 53 class class NN cord-267475-6f4h3cck 1054 54 II II NNP cord-267475-6f4h3cck 1054 55 region region NN cord-267475-6f4h3cck 1054 56 using use VBG cord-267475-6f4h3cck 1054 57 lymphocytes lymphocyte NNS cord-267475-6f4h3cck 1054 58 from from IN cord-267475-6f4h3cck 1054 59 a a DT cord-267475-6f4h3cck 1054 60 patient patient NN cord-267475-6f4h3cck 1054 61 with with IN cord-267475-6f4h3cck 1054 62 a a DT cord-267475-6f4h3cck 1054 63 durable durable JJ cord-267475-6f4h3cck 1054 64 complete complete JJ cord-267475-6f4h3cck 1054 65 regression regression NN cord-267475-6f4h3cck 1054 66 following follow VBG cord-267475-6f4h3cck 1054 67 immunotherapy immunotherapy NN cord-267475-6f4h3cck 1054 68 Cell cell NN cord-267475-6f4h3cck 1054 69 - - HYPH cord-267475-6f4h3cck 1054 70 specific specific JJ cord-267475-6f4h3cck 1054 71 translational translational JJ cord-267475-6f4h3cck 1054 72 regulation regulation NN cord-267475-6f4h3cck 1054 73 of of IN cord-267475-6f4h3cck 1054 74 S S NNP cord-267475-6f4h3cck 1054 75 - - HYPH cord-267475-6f4h3cck 1054 76 adenosylmethionine adenosylmethionine NNP cord-267475-6f4h3cck 1054 77 decarboxylase decarboxylase NN cord-267475-6f4h3cck 1054 78 mRNA mRNA NNP cord-267475-6f4h3cck 1054 79 . . . cord-267475-6f4h3cck 1055 1 Influence influence NN cord-267475-6f4h3cck 1055 2 of of IN cord-267475-6f4h3cck 1055 3 the the DT cord-267475-6f4h3cck 1055 4 structure structure NN cord-267475-6f4h3cck 1055 5 of of IN cord-267475-6f4h3cck 1055 6 the the DT cord-267475-6f4h3cck 1055 7 5 5 CD cord-267475-6f4h3cck 1055 8 0 0 CD cord-267475-6f4h3cck 1055 9 transcript transcript NN cord-267475-6f4h3cck 1055 10 leader leader NN cord-267475-6f4h3cck 1055 11 on on IN cord-267475-6f4h3cck 1055 12 regulation regulation NN cord-267475-6f4h3cck 1055 13 by by IN cord-267475-6f4h3cck 1055 14 the the DT cord-267475-6f4h3cck 1055 15 upstream upstream JJ cord-267475-6f4h3cck 1055 16 open open JJ cord-267475-6f4h3cck 1055 17 reading reading NN cord-267475-6f4h3cck 1055 18 frame frame NN cord-267475-6f4h3cck 1055 19 Block Block NNP cord-267475-6f4h3cck 1055 20 of of IN cord-267475-6f4h3cck 1055 21 HAC1 HAC1 NNP cord-267475-6f4h3cck 1056 1 mRNA mRNA NNP cord-267475-6f4h3cck 1056 2 translation translation NN cord-267475-6f4h3cck 1056 3 by by IN cord-267475-6f4h3cck 1056 4 long long JJ cord-267475-6f4h3cck 1056 5 - - HYPH cord-267475-6f4h3cck 1056 6 range range NN cord-267475-6f4h3cck 1056 7 base base NN cord-267475-6f4h3cck 1056 8 pairing pairing NN cord-267475-6f4h3cck 1056 9 is be VBZ cord-267475-6f4h3cck 1056 10 released release VBN cord-267475-6f4h3cck 1056 11 by by IN cord-267475-6f4h3cck 1056 12 cytoplasmic cytoplasmic JJ cord-267475-6f4h3cck 1056 13 splicing splicing NN cord-267475-6f4h3cck 1056 14 upon upon IN cord-267475-6f4h3cck 1056 15 induction induction NN cord-267475-6f4h3cck 1056 16 of of IN cord-267475-6f4h3cck 1056 17 the the DT cord-267475-6f4h3cck 1056 18 unfolded unfolded JJ cord-267475-6f4h3cck 1056 19 protein protein NN cord-267475-6f4h3cck 1056 20 response response NN cord-267475-6f4h3cck 1056 21 Regulation regulation NN cord-267475-6f4h3cck 1056 22 of of IN cord-267475-6f4h3cck 1056 23 alternative alternative JJ cord-267475-6f4h3cck 1056 24 splicing splicing NN cord-267475-6f4h3cck 1056 25 by by IN cord-267475-6f4h3cck 1056 26 RNA RNA NNP cord-267475-6f4h3cck 1056 27 editing edit VBG cord-267475-6f4h3cck 1056 28 Continuous continuous JJ cord-267475-6f4h3cck 1056 29 and and CC cord-267475-6f4h3cck 1056 30 discontinuous discontinuous JJ cord-267475-6f4h3cck 1056 31 ribosome ribosome NN cord-267475-6f4h3cck 1056 32 scanning scanning NN cord-267475-6f4h3cck 1056 33 on on IN cord-267475-6f4h3cck 1056 34 the the DT cord-267475-6f4h3cck 1056 35 cauliflower cauliflower NN cord-267475-6f4h3cck 1056 36 mosaic mosaic NNP cord-267475-6f4h3cck 1056 37 virus virus NN cord-267475-6f4h3cck 1057 1 35S 35S NNP cord-267475-6f4h3cck 1057 2 RNA RNA NNP cord-267475-6f4h3cck 1057 3 leader leader NN cord-267475-6f4h3cck 1057 4 is be VBZ cord-267475-6f4h3cck 1057 5 controlled control VBN cord-267475-6f4h3cck 1057 6 by by IN cord-267475-6f4h3cck 1057 7 short short JJ cord-267475-6f4h3cck 1057 8 open open JJ cord-267475-6f4h3cck 1057 9 reading reading NN cord-267475-6f4h3cck 1057 10 frames frame NNS cord-267475-6f4h3cck 1057 11 A a DT cord-267475-6f4h3cck 1057 12 complex complex JJ cord-267475-6f4h3cck 1057 13 translational translational JJ cord-267475-6f4h3cck 1057 14 program program NN cord-267475-6f4h3cck 1057 15 generates generate VBZ cord-267475-6f4h3cck 1057 16 multiple multiple JJ cord-267475-6f4h3cck 1057 17 novel novel JJ cord-267475-6f4h3cck 1057 18 proteins protein NNS cord-267475-6f4h3cck 1057 19 from from IN cord-267475-6f4h3cck 1057 20 the the DT cord-267475-6f4h3cck 1057 21 latently latently RB cord-267475-6f4h3cck 1057 22 expressed express VBN cord-267475-6f4h3cck 1057 23 Kaposin Kaposin NNP cord-267475-6f4h3cck 1057 24 ( ( -LRB- cord-267475-6f4h3cck 1057 25 K12 K12 NNP cord-267475-6f4h3cck 1057 26 ) ) -RRB- cord-267475-6f4h3cck 1057 27 locus locus NN cord-267475-6f4h3cck 1057 28 of of IN cord-267475-6f4h3cck 1057 29 Kaposi Kaposi NNP cord-267475-6f4h3cck 1057 30 's 's POS cord-267475-6f4h3cck 1057 31 sarcoma sarcoma NN cord-267475-6f4h3cck 1057 32 - - HYPH cord-267475-6f4h3cck 1057 33 associated associate VBN cord-267475-6f4h3cck 1057 34 herpesvirus herpesvirus NN cord-267475-6f4h3cck 1057 35 Correlation correlation NN cord-267475-6f4h3cck 1057 36 between between IN cord-267475-6f4h3cck 1057 37 sequence sequence NN cord-267475-6f4h3cck 1057 38 conservation conservation NN cord-267475-6f4h3cck 1057 39 of of IN cord-267475-6f4h3cck 1057 40 the the DT cord-267475-6f4h3cck 1057 41 5 5 CD cord-267475-6f4h3cck 1057 42 0 0 CD cord-267475-6f4h3cck 1057 43 untranslated untranslated JJ cord-267475-6f4h3cck 1057 44 region region NN cord-267475-6f4h3cck 1057 45 and and CC cord-267475-6f4h3cck 1057 46 codon codon NN cord-267475-6f4h3cck 1057 47 usage usage NN cord-267475-6f4h3cck 1057 48 bias bias NN cord-267475-6f4h3cck 1057 49 in in IN cord-267475-6f4h3cck 1057 50 Mus Mus NNP cord-267475-6f4h3cck 1057 51 musculus musculus NN cord-267475-6f4h3cck 1057 52 genes gene NNS cord-267475-6f4h3cck 1057 53 COT COT NNP cord-267475-6f4h3cck 1057 54 kinase kinase NN cord-267475-6f4h3cck 1057 55 proto proto JJ cord-267475-6f4h3cck 1057 56 - - HYPH cord-267475-6f4h3cck 1057 57 oncogene oncogene NN cord-267475-6f4h3cck 1057 58 expression expression NN cord-267475-6f4h3cck 1057 59 in in IN cord-267475-6f4h3cck 1057 60 T t NN cord-267475-6f4h3cck 1057 61 cells cell NNS cord-267475-6f4h3cck 1057 62 N n CD cord-267475-6f4h3cck 1057 63 - - HYPH cord-267475-6f4h3cck 1057 64 terminal terminal JJ cord-267475-6f4h3cck 1057 65 RAG1 RAG1 NNP cord-267475-6f4h3cck 1057 66 frameshift frameshift NN cord-267475-6f4h3cck 1057 67 mutations mutation NNS cord-267475-6f4h3cck 1057 68 in in IN cord-267475-6f4h3cck 1057 69 Omenn Omenn NNP cord-267475-6f4h3cck 1057 70 's 's POS cord-267475-6f4h3cck 1057 71 syndrome syndrome NN cord-267475-6f4h3cck 1057 72 : : : cord-267475-6f4h3cck 1057 73 internal internal JJ cord-267475-6f4h3cck 1057 74 methionine methionine NN cord-267475-6f4h3cck 1057 75 usage usage NN cord-267475-6f4h3cck 1057 76 leads lead NNS cord-267475-6f4h3cck 1057 77 to to IN cord-267475-6f4h3cck 1057 78 partial partial JJ cord-267475-6f4h3cck 1057 79 V(D)J V(D)J NNP cord-267475-6f4h3cck 1057 80 recombination recombination NN cord-267475-6f4h3cck 1057 81 activity activity NN cord-267475-6f4h3cck 1057 82 and and CC cord-267475-6f4h3cck 1057 83 reveals reveal VBZ cord-267475-6f4h3cck 1057 84 a a DT cord-267475-6f4h3cck 1057 85 fundamental fundamental JJ cord-267475-6f4h3cck 1057 86 role role NN cord-267475-6f4h3cck 1057 87 in in IN cord-267475-6f4h3cck 1057 88 vivo vivo NN cord-267475-6f4h3cck 1057 89 for for IN cord-267475-6f4h3cck 1057 90 the the DT cord-267475-6f4h3cck 1057 91 N n CD cord-267475-6f4h3cck 1057 92 - - HYPH cord-267475-6f4h3cck 1057 93 terminal terminal NN cord-267475-6f4h3cck 1057 94 domains domain NNS cord-267475-6f4h3cck 1057 95 Complete complete VBP cord-267475-6f4h3cck 1057 96 genomic genomic JJ cord-267475-6f4h3cck 1057 97 sequence sequence NN cord-267475-6f4h3cck 1057 98 of of IN cord-267475-6f4h3cck 1057 99 the the DT cord-267475-6f4h3cck 1057 100 human human JJ cord-267475-6f4h3cck 1057 101 ABCA1 ABCA1 NNP cord-267475-6f4h3cck 1057 102 gene gene NN cord-267475-6f4h3cck 1057 103 : : : cord-267475-6f4h3cck 1057 104 analysis analysis NN cord-267475-6f4h3cck 1057 105 of of IN cord-267475-6f4h3cck 1057 106 the the DT cord-267475-6f4h3cck 1057 107 human human NN cord-267475-6f4h3cck 1057 108 and and CC cord-267475-6f4h3cck 1057 109 mouse mouse NN cord-267475-6f4h3cck 1057 110 ATP ATP NNP cord-267475-6f4h3cck 1057 111 - - HYPH cord-267475-6f4h3cck 1057 112 binding bind VBG cord-267475-6f4h3cck 1057 113 cassette cassette NN cord-267475-6f4h3cck 1057 114 A A NNP cord-267475-6f4h3cck 1057 115 promoter promoter NN cord-267475-6f4h3cck 1057 116 The the DT cord-267475-6f4h3cck 1057 117 pim-1 pim-1 NNP cord-267475-6f4h3cck 1057 118 oncogene oncogene NN cord-267475-6f4h3cck 1057 119 encodes encode VBZ cord-267475-6f4h3cck 1057 120 two two CD cord-267475-6f4h3cck 1057 121 related related JJ cord-267475-6f4h3cck 1057 122 protein protein NN cord-267475-6f4h3cck 1057 123 - - HYPH cord-267475-6f4h3cck 1057 124 serine serine NN cord-267475-6f4h3cck 1057 125 / / SYM cord-267475-6f4h3cck 1057 126 threonine threonine NN cord-267475-6f4h3cck 1057 127 kinases kinase NNS cord-267475-6f4h3cck 1057 128 by by IN cord-267475-6f4h3cck 1057 129 alternative alternative JJ cord-267475-6f4h3cck 1057 130 initiation initiation NN cord-267475-6f4h3cck 1057 131 at at IN cord-267475-6f4h3cck 1057 132 AUG AUG NNP cord-267475-6f4h3cck 1057 133 and and CC cord-267475-6f4h3cck 1057 134 CUG CUG NNP cord-267475-6f4h3cck 1057 135 Negative negative JJ cord-267475-6f4h3cck 1057 136 and and CC cord-267475-6f4h3cck 1057 137 translation translation NN cord-267475-6f4h3cck 1057 138 termination termination NN cord-267475-6f4h3cck 1057 139 - - HYPH cord-267475-6f4h3cck 1057 140 dependent dependent JJ cord-267475-6f4h3cck 1057 141 positive positive JJ cord-267475-6f4h3cck 1057 142 control control NN cord-267475-6f4h3cck 1057 143 of of IN cord-267475-6f4h3cck 1057 144 FLI-1 FLI-1 NNP cord-267475-6f4h3cck 1057 145 protein protein NN cord-267475-6f4h3cck 1057 146 synthesis synthesis NN cord-267475-6f4h3cck 1057 147 by by IN cord-267475-6f4h3cck 1057 148 conserved conserve VBN cord-267475-6f4h3cck 1057 149 overlapping overlap VBG cord-267475-6f4h3cck 1057 150 5 5 CD cord-267475-6f4h3cck 1057 151 0 0 CD cord-267475-6f4h3cck 1057 152 upstream upstream NN cord-267475-6f4h3cck 1057 153 open open JJ cord-267475-6f4h3cck 1057 154 reading reading NN cord-267475-6f4h3cck 1057 155 frames frame NNS cord-267475-6f4h3cck 1057 156 in in IN cord-267475-6f4h3cck 1057 157 Fli-1 Fli-1 NNP cord-267475-6f4h3cck 1057 158 mRNA mRNA NNP cord-267475-6f4h3cck 1057 159 Normal normal JJ cord-267475-6f4h3cck 1057 160 developing develop VBG cord-267475-6f4h3cck 1057 161 rat rat NN cord-267475-6f4h3cck 1057 162 brain brain NN cord-267475-6f4h3cck 1057 163 expresses express VBZ cord-267475-6f4h3cck 1057 164 a a DT cord-267475-6f4h3cck 1057 165 platelet platelet NN cord-267475-6f4h3cck 1057 166 - - HYPH cord-267475-6f4h3cck 1057 167 derived derive VBN cord-267475-6f4h3cck 1057 168 growth growth NN cord-267475-6f4h3cck 1057 169 factor factor NN cord-267475-6f4h3cck 1057 170 B B NNP cord-267475-6f4h3cck 1057 171 chain chain NN cord-267475-6f4h3cck 1058 1 ( ( -LRB- cord-267475-6f4h3cck 1058 2 c c NNP cord-267475-6f4h3cck 1058 3 - - HYPH cord-267475-6f4h3cck 1058 4 sis sis NNP cord-267475-6f4h3cck 1058 5 ) ) -RRB- cord-267475-6f4h3cck 1058 6 mRNA mRNA NNP cord-267475-6f4h3cck 1058 7 truncated truncate VBD cord-267475-6f4h3cck 1058 8 at at IN cord-267475-6f4h3cck 1059 1 the the DT cord-267475-6f4h3cck 1059 2 5 5 CD cord-267475-6f4h3cck 1059 3 0 0 CD cord-267475-6f4h3cck 1059 4 end end NN cord-267475-6f4h3cck 1059 5 Multiple multiple JJ cord-267475-6f4h3cck 1059 6 murine murine JJ cord-267475-6f4h3cck 1059 7 double double JJ cord-267475-6f4h3cck 1059 8 minute minute NN cord-267475-6f4h3cck 1059 9 gene gene NN cord-267475-6f4h3cck 1059 10 2 2 CD cord-267475-6f4h3cck 1059 11 ( ( -LRB- cord-267475-6f4h3cck 1059 12 MDM2 MDM2 NNP cord-267475-6f4h3cck 1059 13 ) ) -RRB- cord-267475-6f4h3cck 1059 14 proteins protein NNS cord-267475-6f4h3cck 1059 15 are be VBP cord-267475-6f4h3cck 1059 16 induced induce VBN cord-267475-6f4h3cck 1059 17 by by IN cord-267475-6f4h3cck 1059 18 ultraviolet ultraviolet NN cord-267475-6f4h3cck 1059 19 light light NN cord-267475-6f4h3cck 1059 20 Transcriptional Transcriptional NNP cord-267475-6f4h3cck 1059 21 control control NN cord-267475-6f4h3cck 1059 22 of of IN cord-267475-6f4h3cck 1059 23 hepadnavirus hepadnavirus NNP cord-267475-6f4h3cck 1059 24 gene gene NNP cord-267475-6f4h3cck 1059 25 expression expression NN cord-267475-6f4h3cck 1059 26 Internal internal JJ cord-267475-6f4h3cck 1059 27 translation translation NN cord-267475-6f4h3cck 1059 28 initiation initiation NN cord-267475-6f4h3cck 1059 29 generates generate VBZ cord-267475-6f4h3cck 1059 30 novel novel NN cord-267475-6f4h3cck 1059 31 WT1 WT1 NNP cord-267475-6f4h3cck 1059 32 protein protein NN cord-267475-6f4h3cck 1059 33 isoforms isoform NNS cord-267475-6f4h3cck 1059 34 with with IN cord-267475-6f4h3cck 1059 35 distinct distinct JJ cord-267475-6f4h3cck 1059 36 biological biological JJ cord-267475-6f4h3cck 1059 37 properties property NNS cord-267475-6f4h3cck 1059 38 Caveolin Caveolin NNP cord-267475-6f4h3cck 1059 39 isoforms isoform NNS cord-267475-6f4h3cck 1059 40 differ differ VBP cord-267475-6f4h3cck 1059 41 in in IN cord-267475-6f4h3cck 1059 42 their -PRON- PRP$ cord-267475-6f4h3cck 1059 43 N n CD cord-267475-6f4h3cck 1059 44 - - HYPH cord-267475-6f4h3cck 1059 45 terminal terminal NN cord-267475-6f4h3cck 1059 46 protein protein NN cord-267475-6f4h3cck 1059 47 sequence sequence NN cord-267475-6f4h3cck 1059 48 and and CC cord-267475-6f4h3cck 1059 49 subcellular subcellular JJ cord-267475-6f4h3cck 1059 50 distribution distribution NN cord-267475-6f4h3cck 1059 51 Identification identification NN cord-267475-6f4h3cck 1059 52 and and CC cord-267475-6f4h3cck 1059 53 functional functional JJ cord-267475-6f4h3cck 1059 54 analysis analysis NN cord-267475-6f4h3cck 1059 55 of of IN cord-267475-6f4h3cck 1059 56 the the DT cord-267475-6f4h3cck 1059 57 turnip turnip NN cord-267475-6f4h3cck 1059 58 yellow yellow NN cord-267475-6f4h3cck 1059 59 mosaic mosaic NNP cord-267475-6f4h3cck 1059 60 tymovirus tymovirus NNP cord-267475-6f4h3cck 1059 61 subgenomic subgenomic NNP cord-267475-6f4h3cck 1059 62 promoter promoter NNP cord-267475-6f4h3cck 1059 63 A a DT cord-267475-6f4h3cck 1059 64 second second JJ cord-267475-6f4h3cck 1059 65 major major JJ cord-267475-6f4h3cck 1059 66 native native NN cord-267475-6f4h3cck 1059 67 von von NNP cord-267475-6f4h3cck 1059 68 Hippel Hippel NNP cord-267475-6f4h3cck 1059 69 - - HYPH cord-267475-6f4h3cck 1059 70 Lindau Lindau NNP cord-267475-6f4h3cck 1059 71 gene gene NN cord-267475-6f4h3cck 1059 72 product product NN cord-267475-6f4h3cck 1059 73 , , , cord-267475-6f4h3cck 1059 74 initiated initiate VBN cord-267475-6f4h3cck 1059 75 from from IN cord-267475-6f4h3cck 1059 76 an an DT cord-267475-6f4h3cck 1059 77 internal internal JJ cord-267475-6f4h3cck 1059 78 translation translation NN cord-267475-6f4h3cck 1059 79 start start NN cord-267475-6f4h3cck 1059 80 site site NN cord-267475-6f4h3cck 1059 81 , , , cord-267475-6f4h3cck 1059 82 functions function VBZ cord-267475-6f4h3cck 1059 83 as as IN cord-267475-6f4h3cck 1059 84 a a DT cord-267475-6f4h3cck 1059 85 tumor tumor NN cord-267475-6f4h3cck 1059 86 suppressor suppressor NN cord-267475-6f4h3cck 1060 1 An an DT cord-267475-6f4h3cck 1060 2 amino amino NN cord-267475-6f4h3cck 1060 3 - - HYPH cord-267475-6f4h3cck 1060 4 terminal terminal NN cord-267475-6f4h3cck 1060 5 domain domain NN cord-267475-6f4h3cck 1060 6 of of IN cord-267475-6f4h3cck 1060 7 Mxi1 Mxi1 NNP cord-267475-6f4h3cck 1060 8 mediates mediate VBZ cord-267475-6f4h3cck 1060 9 anti anti JJ cord-267475-6f4h3cck 1060 10 - - JJ cord-267475-6f4h3cck 1060 11 myc myc JJ cord-267475-6f4h3cck 1060 12 oncogenic oncogenic JJ cord-267475-6f4h3cck 1060 13 activity activity NN cord-267475-6f4h3cck 1060 14 and and CC cord-267475-6f4h3cck 1060 15 interacts interact VBZ cord-267475-6f4h3cck 1060 16 with with IN cord-267475-6f4h3cck 1060 17 a a DT cord-267475-6f4h3cck 1060 18 homolog homolog NN cord-267475-6f4h3cck 1060 19 of of IN cord-267475-6f4h3cck 1060 20 the the DT cord-267475-6f4h3cck 1060 21 yeast yeast NN cord-267475-6f4h3cck 1060 22 transcriptional transcriptional NN cord-267475-6f4h3cck 1060 23 repressor repressor NN cord-267475-6f4h3cck 1060 24 SIN3 SIN3 NNP cord-267475-6f4h3cck 1060 25 Mechanism Mechanism NNP cord-267475-6f4h3cck 1060 26 of of IN cord-267475-6f4h3cck 1060 27 translation translation NN cord-267475-6f4h3cck 1060 28 of of IN cord-267475-6f4h3cck 1060 29 monocistronic monocistronic NNP cord-267475-6f4h3cck 1060 30 and and CC cord-267475-6f4h3cck 1060 31 multicistronic multicistronic NNP cord-267475-6f4h3cck 1060 32 human human JJ cord-267475-6f4h3cck 1060 33 immunodeficiency immunodeficiency NN cord-267475-6f4h3cck 1060 34 virus virus NN cord-267475-6f4h3cck 1060 35 type type NN cord-267475-6f4h3cck 1060 36 1 1 CD cord-267475-6f4h3cck 1061 1 mRNAs mrnas LS cord-267475-6f4h3cck 1061 2 Mechanisms mechanism NNS cord-267475-6f4h3cck 1061 3 of of IN cord-267475-6f4h3cck 1061 4 synthesis synthesis NN cord-267475-6f4h3cck 1061 5 of of IN cord-267475-6f4h3cck 1061 6 virion virion NN cord-267475-6f4h3cck 1061 7 proteins protein NNS cord-267475-6f4h3cck 1061 8 from from IN cord-267475-6f4h3cck 1061 9 the the DT cord-267475-6f4h3cck 1061 10 functionally functionally RB cord-267475-6f4h3cck 1061 11 bigenic bigenic JJ cord-267475-6f4h3cck 1061 12 late late RB cord-267475-6f4h3cck 1061 13 mRNAs mrnas CD cord-267475-6f4h3cck 1061 14 of of IN cord-267475-6f4h3cck 1061 15 simian simian JJ cord-267475-6f4h3cck 1061 16 virus virus NN cord-267475-6f4h3cck 1061 17 40 40 CD cord-267475-6f4h3cck 1061 18 Translation translation NN cord-267475-6f4h3cck 1061 19 initiation initiation NN cord-267475-6f4h3cck 1061 20 at at IN cord-267475-6f4h3cck 1061 21 a a DT cord-267475-6f4h3cck 1061 22 downstream downstream JJ cord-267475-6f4h3cck 1061 23 AUG AUG NNP cord-267475-6f4h3cck 1061 24 occurs occur VBZ cord-267475-6f4h3cck 1061 25 with with IN cord-267475-6f4h3cck 1061 26 increased increase VBN cord-267475-6f4h3cck 1061 27 efficiency efficiency NN cord-267475-6f4h3cck 1061 28 when when WRB cord-267475-6f4h3cck 1061 29 the the DT cord-267475-6f4h3cck 1061 30 upstream upstream JJ cord-267475-6f4h3cck 1061 31 AUG AUG NNP cord-267475-6f4h3cck 1061 32 is be VBZ cord-267475-6f4h3cck 1061 33 located locate VBN cord-267475-6f4h3cck 1061 34 very very RB cord-267475-6f4h3cck 1061 35 close close RB cord-267475-6f4h3cck 1061 36 to to IN cord-267475-6f4h3cck 1061 37 the the DT cord-267475-6f4h3cck 1061 38 5 5 CD cord-267475-6f4h3cck 1061 39 0 0 CD cord-267475-6f4h3cck 1061 40 cap cap NN cord-267475-6f4h3cck 1061 41 Cloning cloning NN cord-267475-6f4h3cck 1061 42 , , , cord-267475-6f4h3cck 1061 43 expression expression NN cord-267475-6f4h3cck 1061 44 , , , cord-267475-6f4h3cck 1061 45 and and CC cord-267475-6f4h3cck 1061 46 nucleotide nucleotide JJ cord-267475-6f4h3cck 1061 47 sequence sequence NN cord-267475-6f4h3cck 1061 48 of of IN cord-267475-6f4h3cck 1061 49 rat rat NN cord-267475-6f4h3cck 1061 50 liver liver NN cord-267475-6f4h3cck 1061 51 sterol sterol NN cord-267475-6f4h3cck 1061 52 carrier carrier NN cord-267475-6f4h3cck 1061 53 protein protein NN cord-267475-6f4h3cck 1061 54 2 2 CD cord-267475-6f4h3cck 1062 1 cDNAs cdnas LS cord-267475-6f4h3cck 1062 2 Bovine bovine JJ cord-267475-6f4h3cck 1062 3 coronavirus coronavirus NN cord-267475-6f4h3cck 1063 1 I -PRON- PRP cord-267475-6f4h3cck 1063 2 protein protein NN cord-267475-6f4h3cck 1063 3 synthesis synthesis NN cord-267475-6f4h3cck 1063 4 follows follow VBZ cord-267475-6f4h3cck 1063 5 ribosomal ribosomal JJ cord-267475-6f4h3cck 1063 6 scanning scanning NN cord-267475-6f4h3cck 1063 7 on on IN cord-267475-6f4h3cck 1063 8 the the DT cord-267475-6f4h3cck 1063 9 bicistronic bicistronic JJ cord-267475-6f4h3cck 1063 10 N N NNP cord-267475-6f4h3cck 1063 11 mRNA mRNA NNP cord-267475-6f4h3cck 1063 12 Ubiquitinactivating Ubiquitinactivating NNP cord-267475-6f4h3cck 1063 13 enzyme enzyme NN cord-267475-6f4h3cck 1063 14 ( ( -LRB- cord-267475-6f4h3cck 1063 15 E1 E1 NNP cord-267475-6f4h3cck 1063 16 ) ) -RRB- cord-267475-6f4h3cck 1063 17 isoforms isoform NNS cord-267475-6f4h3cck 1063 18 in in IN cord-267475-6f4h3cck 1063 19 lens lens NN cord-267475-6f4h3cck 1063 20 epithelial epithelial JJ cord-267475-6f4h3cck 1063 21 cells cell NNS cord-267475-6f4h3cck 1063 22 : : : cord-267475-6f4h3cck 1063 23 origin origin NN cord-267475-6f4h3cck 1063 24 of of IN cord-267475-6f4h3cck 1063 25 translation translation NN cord-267475-6f4h3cck 1063 26 , , , cord-267475-6f4h3cck 1063 27 E2 E2 NNP cord-267475-6f4h3cck 1063 28 specificity specificity NN cord-267475-6f4h3cck 1063 29 and and CC cord-267475-6f4h3cck 1063 30 cellular cellular JJ cord-267475-6f4h3cck 1063 31 localization localization NN cord-267475-6f4h3cck 1063 32 determined determine VBN cord-267475-6f4h3cck 1063 33 with with IN cord-267475-6f4h3cck 1063 34 novel novel JJ cord-267475-6f4h3cck 1063 35 site site NN cord-267475-6f4h3cck 1063 36 - - HYPH cord-267475-6f4h3cck 1063 37 specific specific JJ cord-267475-6f4h3cck 1063 38 antibodies antibody NNS cord-267475-6f4h3cck 1063 39 Cloning clone VBG cord-267475-6f4h3cck 1063 40 and and CC cord-267475-6f4h3cck 1063 41 characterization characterization NN cord-267475-6f4h3cck 1063 42 of of IN cord-267475-6f4h3cck 1063 43 liverspecific liverspecific NNP cord-267475-6f4h3cck 1063 44 isoform isoform NN cord-267475-6f4h3cck 1063 45 of of IN cord-267475-6f4h3cck 1063 46 Chk1 Chk1 NNP cord-267475-6f4h3cck 1063 47 gene gene NN cord-267475-6f4h3cck 1063 48 from from IN cord-267475-6f4h3cck 1063 49 rat rat NN cord-267475-6f4h3cck 1063 50 Producing Producing NNP cord-267475-6f4h3cck 1063 51 nature nature NN cord-267475-6f4h3cck 1063 52 's 's POS cord-267475-6f4h3cck 1063 53 gene gene NN cord-267475-6f4h3cck 1063 54 - - HYPH cord-267475-6f4h3cck 1063 55 chips chip NNS cord-267475-6f4h3cck 1063 56 : : : cord-267475-6f4h3cck 1063 57 the the DT cord-267475-6f4h3cck 1063 58 generation generation NN cord-267475-6f4h3cck 1063 59 of of IN cord-267475-6f4h3cck 1063 60 peptides peptide NNS cord-267475-6f4h3cck 1063 61 for for IN cord-267475-6f4h3cck 1063 62 display display NN cord-267475-6f4h3cck 1063 63 by by IN cord-267475-6f4h3cck 1063 64 MHC MHC NNP cord-267475-6f4h3cck 1063 65 class class NN cord-267475-6f4h3cck 1064 1 I -PRON- PRP cord-267475-6f4h3cck 1064 2 molecules molecule NNS cord-267475-6f4h3cck 1065 1 Preferential preferential JJ cord-267475-6f4h3cck 1065 2 ribosomal ribosomal JJ cord-267475-6f4h3cck 1065 3 scanning scanning NN cord-267475-6f4h3cck 1065 4 is be VBZ cord-267475-6f4h3cck 1065 5 involved involve VBN cord-267475-6f4h3cck 1065 6 in in IN cord-267475-6f4h3cck 1065 7 the the DT cord-267475-6f4h3cck 1065 8 differential differential JJ cord-267475-6f4h3cck 1065 9 synthesis synthesis NN cord-267475-6f4h3cck 1065 10 of of IN cord-267475-6f4h3cck 1065 11 the the DT cord-267475-6f4h3cck 1065 12 hepatitis hepatitis NN cord-267475-6f4h3cck 1065 13 B b NN cord-267475-6f4h3cck 1065 14 viral viral JJ cord-267475-6f4h3cck 1065 15 surface surface NN cord-267475-6f4h3cck 1065 16 antigens antigen NNS cord-267475-6f4h3cck 1065 17 from from IN cord-267475-6f4h3cck 1065 18 subgenomic subgenomic NNP cord-267475-6f4h3cck 1065 19 transcripts transcripts NNPS cord-267475-6f4h3cck 1065 20 Translation Translation NNP cord-267475-6f4h3cck 1065 21 of of IN cord-267475-6f4h3cck 1065 22 the the DT cord-267475-6f4h3cck 1065 23 RNAs rna NNS cord-267475-6f4h3cck 1065 24 of of IN cord-267475-6f4h3cck 1065 25 brome brome NNP cord-267475-6f4h3cck 1065 26 mosaic mosaic NNP cord-267475-6f4h3cck 1065 27 virus virus NN cord-267475-6f4h3cck 1065 28 : : : cord-267475-6f4h3cck 1065 29 the the DT cord-267475-6f4h3cck 1065 30 monocistronic monocistronic NNP cord-267475-6f4h3cck 1065 31 nature nature NN cord-267475-6f4h3cck 1065 32 of of IN cord-267475-6f4h3cck 1065 33 RNA1 RNA1 NNP cord-267475-6f4h3cck 1065 34 and and CC cord-267475-6f4h3cck 1065 35 RNA2 RNA2 NNP cord-267475-6f4h3cck 1065 36 Analysis Analysis NNP cord-267475-6f4h3cck 1065 37 of of IN cord-267475-6f4h3cck 1065 38 capsid capsid NN cord-267475-6f4h3cck 1065 39 formation formation NN cord-267475-6f4h3cck 1065 40 of of IN cord-267475-6f4h3cck 1065 41 human human JJ cord-267475-6f4h3cck 1065 42 polyomavirus polyomavirus JJ cord-267475-6f4h3cck 1065 43 JC JC NNP cord-267475-6f4h3cck 1065 44 ( ( -LRB- cord-267475-6f4h3cck 1065 45 Tokyo-1 Tokyo-1 NNP cord-267475-6f4h3cck 1065 46 strain strain NN cord-267475-6f4h3cck 1065 47 ) ) -RRB- cord-267475-6f4h3cck 1065 48 by by IN cord-267475-6f4h3cck 1065 49 a a DT cord-267475-6f4h3cck 1065 50 eukaryotic eukaryotic JJ cord-267475-6f4h3cck 1065 51 expression expression NN cord-267475-6f4h3cck 1065 52 system system NN cord-267475-6f4h3cck 1065 53 : : : cord-267475-6f4h3cck 1065 54 splicing splicing NN cord-267475-6f4h3cck 1065 55 of of IN cord-267475-6f4h3cck 1065 56 late late JJ cord-267475-6f4h3cck 1065 57 RNAs rna NNS cord-267475-6f4h3cck 1065 58 , , , cord-267475-6f4h3cck 1065 59 translation translation NN cord-267475-6f4h3cck 1065 60 and and CC cord-267475-6f4h3cck 1065 61 nuclear nuclear JJ cord-267475-6f4h3cck 1065 62 transport transport NN cord-267475-6f4h3cck 1065 63 of of IN cord-267475-6f4h3cck 1065 64 major major JJ cord-267475-6f4h3cck 1065 65 capsid capsid NN cord-267475-6f4h3cck 1065 66 protein protein NN cord-267475-6f4h3cck 1065 67 VP1 VP1 NNP cord-267475-6f4h3cck 1065 68 , , , cord-267475-6f4h3cck 1065 69 and and CC cord-267475-6f4h3cck 1065 70 capsid capsid NN cord-267475-6f4h3cck 1065 71 assembly assembly NN cord-267475-6f4h3cck 1065 72 Sequential Sequential NNP cord-267475-6f4h3cck 1065 73 partially partially RB cord-267475-6f4h3cck 1065 74 overlapping overlap VBG cord-267475-6f4h3cck 1065 75 gene gene NN cord-267475-6f4h3cck 1065 76 arrangement arrangement NN cord-267475-6f4h3cck 1065 77 in in IN cord-267475-6f4h3cck 1065 78 the the DT cord-267475-6f4h3cck 1065 79 tricistronic tricistronic NNP cord-267475-6f4h3cck 1065 80 S1 S1 NNP cord-267475-6f4h3cck 1065 81 genome genome NN cord-267475-6f4h3cck 1065 82 segments segment NNS cord-267475-6f4h3cck 1065 83 of of IN cord-267475-6f4h3cck 1065 84 avian avian JJ cord-267475-6f4h3cck 1065 85 reovirus reovirus NNP cord-267475-6f4h3cck 1065 86 and and CC cord-267475-6f4h3cck 1065 87 Nelson Nelson NNP cord-267475-6f4h3cck 1065 88 Bay Bay NNP cord-267475-6f4h3cck 1065 89 reovirus reovirus NNP cord-267475-6f4h3cck 1065 90 : : : cord-267475-6f4h3cck 1065 91 implications implication NNS cord-267475-6f4h3cck 1065 92 for for IN cord-267475-6f4h3cck 1065 93 translation translation NN cord-267475-6f4h3cck 1065 94 initiation initiation NN cord-267475-6f4h3cck 1065 95 Translational translational JJ cord-267475-6f4h3cck 1065 96 regulation regulation NN cord-267475-6f4h3cck 1065 97 of of IN cord-267475-6f4h3cck 1065 98 the the DT cord-267475-6f4h3cck 1065 99 JunD JunD NNP cord-267475-6f4h3cck 1065 100 messenger messenger NN cord-267475-6f4h3cck 1065 101 RNA RNA NNP cord-267475-6f4h3cck 1065 102 Characterization Characterization NNP cord-267475-6f4h3cck 1065 103 of of IN cord-267475-6f4h3cck 1065 104 the the DT cord-267475-6f4h3cck 1065 105 murine murine JJ cord-267475-6f4h3cck 1065 106 hyaluronidase hyaluronidase NNP cord-267475-6f4h3cck 1065 107 gene gene NN cord-267475-6f4h3cck 1065 108 region region NN cord-267475-6f4h3cck 1065 109 reveals reveal VBZ cord-267475-6f4h3cck 1065 110 complex complex JJ cord-267475-6f4h3cck 1065 111 organization organization NN cord-267475-6f4h3cck 1065 112 and and CC cord-267475-6f4h3cck 1065 113 cotranscription cotranscription NN cord-267475-6f4h3cck 1065 114 of of IN cord-267475-6f4h3cck 1065 115 Hyal1 Hyal1 NNS cord-267475-6f4h3cck 1065 116 with with IN cord-267475-6f4h3cck 1065 117 downstream downstream JJ cord-267475-6f4h3cck 1065 118 genes gene NNS cord-267475-6f4h3cck 1065 119 , , , cord-267475-6f4h3cck 1065 120 Fus2 Fus2 NNP cord-267475-6f4h3cck 1065 121 and and CC cord-267475-6f4h3cck 1065 122 Hyal3 Hyal3 NNP cord-267475-6f4h3cck 1066 1 Polyoma polyoma NN cord-267475-6f4h3cck 1066 2 virus virus NN cord-267475-6f4h3cck 1066 3 has have VBZ cord-267475-6f4h3cck 1066 4 three three CD cord-267475-6f4h3cck 1066 5 late late RB cord-267475-6f4h3cck 1066 6 mRNAs mrnas CD cord-267475-6f4h3cck 1066 7 : : : cord-267475-6f4h3cck 1067 1 one one CD cord-267475-6f4h3cck 1067 2 for for IN cord-267475-6f4h3cck 1067 3 each each DT cord-267475-6f4h3cck 1067 4 virion virion NN cord-267475-6f4h3cck 1067 5 protein protein NN cord-267475-6f4h3cck 1067 6 A a DT cord-267475-6f4h3cck 1067 7 somatic somatic JJ cord-267475-6f4h3cck 1067 8 mutation mutation NN cord-267475-6f4h3cck 1067 9 in in IN cord-267475-6f4h3cck 1067 10 the the DT cord-267475-6f4h3cck 1067 11 5 5 CD cord-267475-6f4h3cck 1067 12 0 0 CD cord-267475-6f4h3cck 1067 13 UTR UTR NNP cord-267475-6f4h3cck 1067 14 of of IN cord-267475-6f4h3cck 1067 15 BRCA1 BRCA1 NNP cord-267475-6f4h3cck 1067 16 gene gene NN cord-267475-6f4h3cck 1067 17 in in IN cord-267475-6f4h3cck 1067 18 sporadic sporadic JJ cord-267475-6f4h3cck 1067 19 breast breast NN cord-267475-6f4h3cck 1067 20 cancer cancer NN cord-267475-6f4h3cck 1067 21 causes cause VBZ cord-267475-6f4h3cck 1067 22 down down IN cord-267475-6f4h3cck 1067 23 - - HYPH cord-267475-6f4h3cck 1067 24 modulation modulation NN cord-267475-6f4h3cck 1067 25 of of IN cord-267475-6f4h3cck 1067 26 translation translation NN cord-267475-6f4h3cck 1067 27 efficiency efficiency NN cord-267475-6f4h3cck 1068 1 The the DT cord-267475-6f4h3cck 1068 2 105-kDa 105-kda CD cord-267475-6f4h3cck 1068 3 polyprotein polyprotein NN cord-267475-6f4h3cck 1068 4 of of IN cord-267475-6f4h3cck 1068 5 southern southern JJ cord-267475-6f4h3cck 1068 6 bean bean NNP cord-267475-6f4h3cck 1068 7 mosaic mosaic NNP cord-267475-6f4h3cck 1068 8 virus virus NN cord-267475-6f4h3cck 1068 9 is be VBZ cord-267475-6f4h3cck 1068 10 translated translate VBN cord-267475-6f4h3cck 1068 11 by by IN cord-267475-6f4h3cck 1068 12 scanning scanning NN cord-267475-6f4h3cck 1068 13 ribosomes ribosome NNS cord-267475-6f4h3cck 1068 14 The the DT cord-267475-6f4h3cck 1068 15 two two CD cord-267475-6f4h3cck 1068 16 subunits subunit NNS cord-267475-6f4h3cck 1068 17 of of IN cord-267475-6f4h3cck 1068 18 human human JJ cord-267475-6f4h3cck 1068 19 molybdopterin molybdopterin NN cord-267475-6f4h3cck 1068 20 synthase synthase NN cord-267475-6f4h3cck 1068 21 : : : cord-267475-6f4h3cck 1068 22 evidence evidence NN cord-267475-6f4h3cck 1068 23 for for IN cord-267475-6f4h3cck 1068 24 a a DT cord-267475-6f4h3cck 1068 25 bicistronic bicistronic JJ cord-267475-6f4h3cck 1068 26 messenger messenger NN cord-267475-6f4h3cck 1068 27 RNA RNA NNP cord-267475-6f4h3cck 1068 28 with with IN cord-267475-6f4h3cck 1068 29 overlapping overlap VBG cord-267475-6f4h3cck 1068 30 reading reading NN cord-267475-6f4h3cck 1068 31 frames frame NNS cord-267475-6f4h3cck 1068 32 Poliovirus Poliovirus NNP cord-267475-6f4h3cck 1068 33 neurovirulence neurovirulence NNP cord-267475-6f4h3cck 1068 34 correlates correlate VBZ cord-267475-6f4h3cck 1068 35 with with IN cord-267475-6f4h3cck 1068 36 the the DT cord-267475-6f4h3cck 1068 37 presence presence NN cord-267475-6f4h3cck 1068 38 of of IN cord-267475-6f4h3cck 1068 39 a a DT cord-267475-6f4h3cck 1068 40 cryptic cryptic JJ cord-267475-6f4h3cck 1068 41 AUG AUG NNP cord-267475-6f4h3cck 1068 42 upstream upstream RB cord-267475-6f4h3cck 1068 43 of of IN cord-267475-6f4h3cck 1069 1 the the DT cord-267475-6f4h3cck 1069 2 initiator initiator NN cord-267475-6f4h3cck 1069 3 codon codon NNP cord-267475-6f4h3cck 1070 1 mRNA mRNA NNP cord-267475-6f4h3cck 1070 2 leader leader NN cord-267475-6f4h3cck 1070 3 length length NN cord-267475-6f4h3cck 1070 4 and and CC cord-267475-6f4h3cck 1071 1 initiation initiation NNP cord-267475-6f4h3cck 1071 2 codon codon NNP cord-267475-6f4h3cck 1071 3 context context NN cord-267475-6f4h3cck 1071 4 determine determine NN cord-267475-6f4h3cck 1071 5 alternative alternative JJ cord-267475-6f4h3cck 1071 6 AUG AUG NNP cord-267475-6f4h3cck 1071 7 selection selection NN cord-267475-6f4h3cck 1071 8 for for IN cord-267475-6f4h3cck 1071 9 the the DT cord-267475-6f4h3cck 1071 10 yeast yeast NN cord-267475-6f4h3cck 1071 11 gene gene NN cord-267475-6f4h3cck 1071 12 MOD5 MOD5 NNP cord-267475-6f4h3cck 1071 13 CHOP chop NN cord-267475-6f4h3cck 1071 14 - - HYPH cord-267475-6f4h3cck 1071 15 dependent dependent JJ cord-267475-6f4h3cck 1071 16 stress stress NN cord-267475-6f4h3cck 1071 17 - - HYPH cord-267475-6f4h3cck 1071 18 inducible inducible JJ cord-267475-6f4h3cck 1071 19 expression expression NN cord-267475-6f4h3cck 1071 20 of of IN cord-267475-6f4h3cck 1071 21 a a DT cord-267475-6f4h3cck 1071 22 novel novel JJ cord-267475-6f4h3cck 1071 23 form form NN cord-267475-6f4h3cck 1071 24 of of IN cord-267475-6f4h3cck 1071 25 carbonic carbonic JJ cord-267475-6f4h3cck 1071 26 anhydrase anhydrase NN cord-267475-6f4h3cck 1071 27 VI VI NNP cord-267475-6f4h3cck 1072 1 The the DT cord-267475-6f4h3cck 1072 2 promoters promoter NNS cord-267475-6f4h3cck 1072 3 for for IN cord-267475-6f4h3cck 1072 4 human human NN cord-267475-6f4h3cck 1072 5 and and CC cord-267475-6f4h3cck 1072 6 monkey monkey NN cord-267475-6f4h3cck 1072 7 poliovirus poliovirus NN cord-267475-6f4h3cck 1072 8 receptors receptor NNS cord-267475-6f4h3cck 1072 9 Characterization characterization NN cord-267475-6f4h3cck 1072 10 of of IN cord-267475-6f4h3cck 1072 11 two two CD cord-267475-6f4h3cck 1072 12 bifunctional bifunctional JJ cord-267475-6f4h3cck 1072 13 Arabidopsis Arabidopsis NNP cord-267475-6f4h3cck 1072 14 thaliana thaliana NN cord-267475-6f4h3cck 1072 15 genes gene NNS cord-267475-6f4h3cck 1072 16 coding code VBG cord-267475-6f4h3cck 1072 17 for for IN cord-267475-6f4h3cck 1072 18 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 1072 19 and and CC cord-267475-6f4h3cck 1072 20 cytosolic cytosolic JJ cord-267475-6f4h3cck 1072 21 forms form NNS cord-267475-6f4h3cck 1072 22 of of IN cord-267475-6f4h3cck 1072 23 valyl valyl JJ cord-267475-6f4h3cck 1072 24 - - HYPH cord-267475-6f4h3cck 1072 25 tRNA trna NN cord-267475-6f4h3cck 1072 26 synthetase synthetase NN cord-267475-6f4h3cck 1072 27 and and CC cord-267475-6f4h3cck 1072 28 threonyl threonyl NNP cord-267475-6f4h3cck 1072 29 - - HYPH cord-267475-6f4h3cck 1072 30 tRNA trna NN cord-267475-6f4h3cck 1072 31 synthetase synthetase NN cord-267475-6f4h3cck 1072 32 by by IN cord-267475-6f4h3cck 1072 33 alternative alternative JJ cord-267475-6f4h3cck 1072 34 use use NN cord-267475-6f4h3cck 1072 35 of of IN cord-267475-6f4h3cck 1072 36 two two CD cord-267475-6f4h3cck 1072 37 in in IN cord-267475-6f4h3cck 1072 38 - - HYPH cord-267475-6f4h3cck 1072 39 frame frame NN cord-267475-6f4h3cck 1072 40 AUGs aug NNS cord-267475-6f4h3cck 1073 1 A a DT cord-267475-6f4h3cck 1073 2 small small JJ cord-267475-6f4h3cck 1073 3 highly highly RB cord-267475-6f4h3cck 1073 4 basic basic JJ cord-267475-6f4h3cck 1073 5 protein protein NN cord-267475-6f4h3cck 1073 6 is be VBZ cord-267475-6f4h3cck 1073 7 encoded encode VBN cord-267475-6f4h3cck 1073 8 in in IN cord-267475-6f4h3cck 1073 9 overlapping overlap VBG cord-267475-6f4h3cck 1073 10 frame frame NN cord-267475-6f4h3cck 1073 11 within within IN cord-267475-6f4h3cck 1073 12 the the DT cord-267475-6f4h3cck 1073 13 P p NN cord-267475-6f4h3cck 1073 14 gene gene NN cord-267475-6f4h3cck 1073 15 of of IN cord-267475-6f4h3cck 1073 16 vesicular vesicular JJ cord-267475-6f4h3cck 1073 17 stomatitis stomatitis NN cord-267475-6f4h3cck 1073 18 virus virus NN cord-267475-6f4h3cck 1073 19 Identification identification NN cord-267475-6f4h3cck 1073 20 of of IN cord-267475-6f4h3cck 1073 21 downstream downstream RB cord-267475-6f4h3cck 1073 22 - - HYPH cord-267475-6f4h3cck 1073 23 initiated initiate VBN cord-267475-6f4h3cck 1073 24 c c NN cord-267475-6f4h3cck 1073 25 - - HYPH cord-267475-6f4h3cck 1073 26 myc myc NNP cord-267475-6f4h3cck 1073 27 proteins protein NNS cord-267475-6f4h3cck 1073 28 which which WDT cord-267475-6f4h3cck 1073 29 are be VBP cord-267475-6f4h3cck 1073 30 dominant dominant JJ cord-267475-6f4h3cck 1073 31 - - HYPH cord-267475-6f4h3cck 1073 32 negative negative JJ cord-267475-6f4h3cck 1073 33 inhibitors inhibitor NNS cord-267475-6f4h3cck 1073 34 of of IN cord-267475-6f4h3cck 1073 35 transactivation transactivation NN cord-267475-6f4h3cck 1073 36 by by IN cord-267475-6f4h3cck 1073 37 full full JJ cord-267475-6f4h3cck 1073 38 - - HYPH cord-267475-6f4h3cck 1073 39 length length NN cord-267475-6f4h3cck 1073 40 c c NN cord-267475-6f4h3cck 1073 41 - - HYPH cord-267475-6f4h3cck 1073 42 myc myc NN cord-267475-6f4h3cck 1073 43 proteins protein NNS cord-267475-6f4h3cck 1073 44 Leaky leaky JJ cord-267475-6f4h3cck 1073 45 scanning scanning NN cord-267475-6f4h3cck 1073 46 is be VBZ cord-267475-6f4h3cck 1073 47 the the DT cord-267475-6f4h3cck 1073 48 predominant predominant JJ cord-267475-6f4h3cck 1073 49 mechanism mechanism NN cord-267475-6f4h3cck 1073 50 for for IN cord-267475-6f4h3cck 1073 51 translation translation NN cord-267475-6f4h3cck 1073 52 of of IN cord-267475-6f4h3cck 1073 53 human human JJ cord-267475-6f4h3cck 1073 54 papillomavirus papillomavirus NN cord-267475-6f4h3cck 1073 55 type type NN cord-267475-6f4h3cck 1073 56 16 16 CD cord-267475-6f4h3cck 1073 57 E7 E7 NNP cord-267475-6f4h3cck 1073 58 oncoprotein oncoprotein NNP cord-267475-6f4h3cck 1073 59 from from IN cord-267475-6f4h3cck 1073 60 E6/ E6/ NNP cord-267475-6f4h3cck 1073 61 E7 E7 NNP cord-267475-6f4h3cck 1073 62 bicistronic bicistronic NNP cord-267475-6f4h3cck 1073 63 mRNA mRNA NNP cord-267475-6f4h3cck 1073 64 Human human JJ cord-267475-6f4h3cck 1073 65 molybdopterin molybdopterin NNP cord-267475-6f4h3cck 1073 66 synthase synthase NN cord-267475-6f4h3cck 1073 67 gene gene NN cord-267475-6f4h3cck 1073 68 : : : cord-267475-6f4h3cck 1073 69 identification identification NN cord-267475-6f4h3cck 1073 70 of of IN cord-267475-6f4h3cck 1073 71 a a DT cord-267475-6f4h3cck 1073 72 bicistronic bicistronic JJ cord-267475-6f4h3cck 1073 73 transcript transcript NN cord-267475-6f4h3cck 1073 74 with with IN cord-267475-6f4h3cck 1073 75 overlapping overlap VBG cord-267475-6f4h3cck 1073 76 reading reading NN cord-267475-6f4h3cck 1073 77 frames frame NNS cord-267475-6f4h3cck 1073 78 Elements element NNS cord-267475-6f4h3cck 1073 79 in in IN cord-267475-6f4h3cck 1073 80 the the DT cord-267475-6f4h3cck 1073 81 murine murine JJ cord-267475-6f4h3cck 1073 82 c c NNP cord-267475-6f4h3cck 1073 83 - - HYPH cord-267475-6f4h3cck 1073 84 mos mos NNP cord-267475-6f4h3cck 1073 85 messenger messenger NNP cord-267475-6f4h3cck 1073 86 RNA RNA NNP cord-267475-6f4h3cck 1074 1 5 5 LS cord-267475-6f4h3cck 1074 2 0 0 CD cord-267475-6f4h3cck 1074 3 -untranslated -untranslated JJ cord-267475-6f4h3cck 1074 4 region region NN cord-267475-6f4h3cck 1074 5 repress repress VB cord-267475-6f4h3cck 1074 6 translation translation NN cord-267475-6f4h3cck 1074 7 of of IN cord-267475-6f4h3cck 1074 8 downstream downstream JJ cord-267475-6f4h3cck 1074 9 coding coding NN cord-267475-6f4h3cck 1074 10 sequences sequence NNS cord-267475-6f4h3cck 1074 11 Regulatory regulatory JJ cord-267475-6f4h3cck 1074 12 role role NN cord-267475-6f4h3cck 1074 13 of of IN cord-267475-6f4h3cck 1074 14 the the DT cord-267475-6f4h3cck 1074 15 conserved conserve VBN cord-267475-6f4h3cck 1074 16 stem stem NN cord-267475-6f4h3cck 1074 17 - - HYPH cord-267475-6f4h3cck 1074 18 loop loop NN cord-267475-6f4h3cck 1074 19 structure structure NN cord-267475-6f4h3cck 1074 20 at at IN cord-267475-6f4h3cck 1074 21 the the DT cord-267475-6f4h3cck 1074 22 5 5 CD cord-267475-6f4h3cck 1074 23 0 0 CD cord-267475-6f4h3cck 1074 24 end end NN cord-267475-6f4h3cck 1074 25 of of IN cord-267475-6f4h3cck 1074 26 collagen collagen NN cord-267475-6f4h3cck 1074 27 a1(I a1(i NN cord-267475-6f4h3cck 1074 28 ) ) -RRB- cord-267475-6f4h3cck 1074 29 mRNA mrna NN cord-267475-6f4h3cck 1075 1 The the DT cord-267475-6f4h3cck 1075 2 alphaviruses alphavirus NNS cord-267475-6f4h3cck 1075 3 : : : cord-267475-6f4h3cck 1075 4 gene gene NN cord-267475-6f4h3cck 1075 5 expression expression NN cord-267475-6f4h3cck 1075 6 , , , cord-267475-6f4h3cck 1075 7 replication replication NN cord-267475-6f4h3cck 1075 8 , , , cord-267475-6f4h3cck 1075 9 and and CC cord-267475-6f4h3cck 1075 10 evolution evolution NN cord-267475-6f4h3cck 1075 11 Characterization characterization NN cord-267475-6f4h3cck 1075 12 of of IN cord-267475-6f4h3cck 1075 13 human human JJ cord-267475-6f4h3cck 1075 14 MAPRE MAPRE NNP cord-267475-6f4h3cck 1075 15 genes gene NNS cord-267475-6f4h3cck 1075 16 and and CC cord-267475-6f4h3cck 1075 17 their -PRON- PRP$ cord-267475-6f4h3cck 1075 18 proteins protein NNS cord-267475-6f4h3cck 1076 1 Calspermin Calspermin NNP cord-267475-6f4h3cck 1076 2 gene gene NN cord-267475-6f4h3cck 1076 3 transcription transcription NN cord-267475-6f4h3cck 1076 4 is be VBZ cord-267475-6f4h3cck 1076 5 regulated regulate VBN cord-267475-6f4h3cck 1076 6 by by IN cord-267475-6f4h3cck 1076 7 two two CD cord-267475-6f4h3cck 1076 8 cyclic cyclic JJ cord-267475-6f4h3cck 1076 9 AMP AMP NNP cord-267475-6f4h3cck 1076 10 response response NN cord-267475-6f4h3cck 1076 11 elements element NNS cord-267475-6f4h3cck 1076 12 contained contain VBN cord-267475-6f4h3cck 1076 13 in in IN cord-267475-6f4h3cck 1076 14 an an DT cord-267475-6f4h3cck 1076 15 alternative alternative JJ cord-267475-6f4h3cck 1076 16 promoter promoter NN cord-267475-6f4h3cck 1076 17 in in IN cord-267475-6f4h3cck 1076 18 the the DT cord-267475-6f4h3cck 1076 19 calmodulin calmodulin NN cord-267475-6f4h3cck 1076 20 kinase kinase VBZ cord-267475-6f4h3cck 1076 21 IV IV NNP cord-267475-6f4h3cck 1076 22 gene gene NN cord-267475-6f4h3cck 1076 23 Structure Structure NNP cord-267475-6f4h3cck 1076 24 of of IN cord-267475-6f4h3cck 1076 25 the the DT cord-267475-6f4h3cck 1076 26 5 5 CD cord-267475-6f4h3cck 1076 27 0 0 CD cord-267475-6f4h3cck 1076 28 flanking flanking NN cord-267475-6f4h3cck 1076 29 region region NN cord-267475-6f4h3cck 1076 30 of of IN cord-267475-6f4h3cck 1076 31 the the DT cord-267475-6f4h3cck 1076 32 gene gene NN cord-267475-6f4h3cck 1076 33 encoding encode VBG cord-267475-6f4h3cck 1076 34 human human JJ cord-267475-6f4h3cck 1076 35 parathyroid parathyroid NN cord-267475-6f4h3cck 1076 36 - - HYPH cord-267475-6f4h3cck 1076 37 hormonerelated hormonerelate VBN cord-267475-6f4h3cck 1076 38 protein protein NN cord-267475-6f4h3cck 1076 39 ( ( -LRB- cord-267475-6f4h3cck 1076 40 PTHrP PTHrP NNP cord-267475-6f4h3cck 1076 41 ) ) -RRB- cord-267475-6f4h3cck 1077 1 Statistical statistical JJ cord-267475-6f4h3cck 1077 2 analysis analysis NN cord-267475-6f4h3cck 1077 3 of of IN cord-267475-6f4h3cck 1077 4 the the DT cord-267475-6f4h3cck 1077 5 5 5 CD cord-267475-6f4h3cck 1077 6 0 0 CD cord-267475-6f4h3cck 1077 7 untranslated untranslated JJ cord-267475-6f4h3cck 1077 8 region region NN cord-267475-6f4h3cck 1077 9 of of IN cord-267475-6f4h3cck 1077 10 human human NN cord-267475-6f4h3cck 1077 11 mRNA mrna NN cord-267475-6f4h3cck 1077 12 using use VBG cord-267475-6f4h3cck 1077 13 " " `` cord-267475-6f4h3cck 1077 14 oligo oligo NN cord-267475-6f4h3cck 1077 15 - - HYPH cord-267475-6f4h3cck 1077 16 capped cap VBN cord-267475-6f4h3cck 1077 17 " " `` cord-267475-6f4h3cck 1077 18 cDNA cdna NN cord-267475-6f4h3cck 1077 19 libraries library NNS cord-267475-6f4h3cck 1077 20 Evidence evidence NN cord-267475-6f4h3cck 1077 21 for for IN cord-267475-6f4h3cck 1077 22 the the DT cord-267475-6f4h3cck 1077 23 existence existence NN cord-267475-6f4h3cck 1077 24 of of IN cord-267475-6f4h3cck 1077 25 a a DT cord-267475-6f4h3cck 1077 26 coat coat NN cord-267475-6f4h3cck 1077 27 protein protein NN cord-267475-6f4h3cck 1077 28 messenger messenger NN cord-267475-6f4h3cck 1077 29 RNA RNA NNP cord-267475-6f4h3cck 1077 30 associated associate VBN cord-267475-6f4h3cck 1077 31 with with IN cord-267475-6f4h3cck 1077 32 the the DT cord-267475-6f4h3cck 1077 33 top top JJ cord-267475-6f4h3cck 1077 34 component component NN cord-267475-6f4h3cck 1077 35 of of IN cord-267475-6f4h3cck 1077 36 each each DT cord-267475-6f4h3cck 1077 37 of of IN cord-267475-6f4h3cck 1077 38 three three CD cord-267475-6f4h3cck 1077 39 tymoviruses tymoviruse NNS cord-267475-6f4h3cck 1077 40 Truncated truncate VBN cord-267475-6f4h3cck 1077 41 forms form NNS cord-267475-6f4h3cck 1077 42 of of IN cord-267475-6f4h3cck 1077 43 the the DT cord-267475-6f4h3cck 1077 44 dual dual JJ cord-267475-6f4h3cck 1077 45 function function NN cord-267475-6f4h3cck 1077 46 human human JJ cord-267475-6f4h3cck 1077 47 ASCT2 asct2 NN cord-267475-6f4h3cck 1077 48 neutral neutral JJ cord-267475-6f4h3cck 1077 49 amino amino NN cord-267475-6f4h3cck 1077 50 acid acid NN cord-267475-6f4h3cck 1077 51 transporter transporter NN cord-267475-6f4h3cck 1077 52 / / SYM cord-267475-6f4h3cck 1077 53 retroviral retroviral JJ cord-267475-6f4h3cck 1077 54 receptor receptor NN cord-267475-6f4h3cck 1077 55 are be VBP cord-267475-6f4h3cck 1077 56 translationally translationally RB cord-267475-6f4h3cck 1077 57 initiated initiate VBN cord-267475-6f4h3cck 1077 58 at at IN cord-267475-6f4h3cck 1077 59 multiple multiple JJ cord-267475-6f4h3cck 1077 60 alternative alternative JJ cord-267475-6f4h3cck 1077 61 CUG CUG NNP cord-267475-6f4h3cck 1077 62 and and CC cord-267475-6f4h3cck 1077 63 GUG GUG NNP cord-267475-6f4h3cck 1077 64 codons codon NNS cord-267475-6f4h3cck 1078 1 The the DT cord-267475-6f4h3cck 1078 2 5 5 CD cord-267475-6f4h3cck 1078 3 0 0 CD cord-267475-6f4h3cck 1078 4 -untranslated -untranslated JJ cord-267475-6f4h3cck 1078 5 region region NN cord-267475-6f4h3cck 1078 6 of of IN cord-267475-6f4h3cck 1078 7 the the DT cord-267475-6f4h3cck 1078 8 mouse mouse NN cord-267475-6f4h3cck 1078 9 glial glial JJ cord-267475-6f4h3cck 1078 10 cell cell NN cord-267475-6f4h3cck 1078 11 line line NN cord-267475-6f4h3cck 1078 12 - - HYPH cord-267475-6f4h3cck 1078 13 derived derive VBN cord-267475-6f4h3cck 1078 14 neurotrophic neurotrophic NN cord-267475-6f4h3cck 1078 15 factor factor NN cord-267475-6f4h3cck 1078 16 gene gene NN cord-267475-6f4h3cck 1078 17 regulates regulate VBZ cord-267475-6f4h3cck 1078 18 expression expression NN cord-267475-6f4h3cck 1078 19 at at IN cord-267475-6f4h3cck 1078 20 both both CC cord-267475-6f4h3cck 1078 21 the the DT cord-267475-6f4h3cck 1078 22 transcriptional transcriptional JJ cord-267475-6f4h3cck 1078 23 and and CC cord-267475-6f4h3cck 1078 24 translational translational JJ cord-267475-6f4h3cck 1078 25 levels level NNS cord-267475-6f4h3cck 1078 26 Testis testis NN cord-267475-6f4h3cck 1078 27 - - HYPH cord-267475-6f4h3cck 1078 28 specific specific JJ cord-267475-6f4h3cck 1078 29 transcription transcription NN cord-267475-6f4h3cck 1078 30 initiation initiation NN cord-267475-6f4h3cck 1078 31 sites site NNS cord-267475-6f4h3cck 1078 32 of of IN cord-267475-6f4h3cck 1078 33 rat rat NNP cord-267475-6f4h3cck 1078 34 farnesyl farnesyl NNP cord-267475-6f4h3cck 1078 35 pyrophosphate pyrophosphate NNP cord-267475-6f4h3cck 1078 36 synthetase synthetase NNP cord-267475-6f4h3cck 1079 1 mRNA mRNA NNP cord-267475-6f4h3cck 1080 1 The the DT cord-267475-6f4h3cck 1080 2 baculovirus baculovirus NN cord-267475-6f4h3cck 1080 3 transcriptional transcriptional JJ cord-267475-6f4h3cck 1080 4 transactivator transactivator NNP cord-267475-6f4h3cck 1080 5 ieO ieO NNP cord-267475-6f4h3cck 1080 6 produces produce VBZ cord-267475-6f4h3cck 1080 7 multiple multiple JJ cord-267475-6f4h3cck 1080 8 products product NNS cord-267475-6f4h3cck 1080 9 by by IN cord-267475-6f4h3cck 1080 10 internal internal JJ cord-267475-6f4h3cck 1080 11 initiation initiation NN cord-267475-6f4h3cck 1080 12 of of IN cord-267475-6f4h3cck 1080 13 translation translation NN cord-267475-6f4h3cck 1080 14 Generation generation NN cord-267475-6f4h3cck 1080 15 of of IN cord-267475-6f4h3cck 1080 16 stable stable JJ cord-267475-6f4h3cck 1080 17 mRNA mrna NN cord-267475-6f4h3cck 1080 18 fragments fragment NNS cord-267475-6f4h3cck 1080 19 and and CC cord-267475-6f4h3cck 1080 20 translation translation NN cord-267475-6f4h3cck 1080 21 of of IN cord-267475-6f4h3cck 1080 22 Ntruncated Ntruncated NNP cord-267475-6f4h3cck 1080 23 proteins protein NNS cord-267475-6f4h3cck 1080 24 induced induce VBN cord-267475-6f4h3cck 1080 25 by by IN cord-267475-6f4h3cck 1080 26 antisense antisense NN cord-267475-6f4h3cck 1080 27 oligonucleotides oligonucleotide NNS cord-267475-6f4h3cck 1081 1 Transcriptional transcriptional JJ cord-267475-6f4h3cck 1081 2 regulation regulation NN cord-267475-6f4h3cck 1081 3 of of IN cord-267475-6f4h3cck 1081 4 the the DT cord-267475-6f4h3cck 1081 5 interferon interferon NN cord-267475-6f4h3cck 1081 6 - - HYPH cord-267475-6f4h3cck 1081 7 g g NN cord-267475-6f4h3cck 1081 8 - - HYPH cord-267475-6f4h3cck 1081 9 inducible inducible JJ cord-267475-6f4h3cck 1081 10 tryptophanyl tryptophanyl NNP cord-267475-6f4h3cck 1081 11 - - HYPH cord-267475-6f4h3cck 1081 12 tRNA tRNA NNP cord-267475-6f4h3cck 1081 13 synthetase synthetase NN cord-267475-6f4h3cck 1081 14 includes include VBZ cord-267475-6f4h3cck 1081 15 alternative alternative JJ cord-267475-6f4h3cck 1081 16 splicing splice VBG cord-267475-6f4h3cck 1081 17 Evidence evidence NN cord-267475-6f4h3cck 1081 18 for for IN cord-267475-6f4h3cck 1081 19 translational translational JJ cord-267475-6f4h3cck 1081 20 regulation regulation NN cord-267475-6f4h3cck 1081 21 of of IN cord-267475-6f4h3cck 1081 22 the the DT cord-267475-6f4h3cck 1081 23 imprinted imprint VBN cord-267475-6f4h3cck 1081 24 Snurf Snurf NNP cord-267475-6f4h3cck 1081 25 - - HYPH cord-267475-6f4h3cck 1081 26 Snrpn Snrpn NNP cord-267475-6f4h3cck 1081 27 locus locus NN cord-267475-6f4h3cck 1081 28 in in IN cord-267475-6f4h3cck 1081 29 mice mouse NNS cord-267475-6f4h3cck 1082 1 Cancerassociated cancerassociated JJ cord-267475-6f4h3cck 1082 2 alternative alternative JJ cord-267475-6f4h3cck 1082 3 usage usage NN cord-267475-6f4h3cck 1082 4 of of IN cord-267475-6f4h3cck 1082 5 multiple multiple JJ cord-267475-6f4h3cck 1082 6 promoters promoter NNS cord-267475-6f4h3cck 1082 7 of of IN cord-267475-6f4h3cck 1082 8 human human JJ cord-267475-6f4h3cck 1082 9 GalCer GalCer NNP cord-267475-6f4h3cck 1082 10 sulfotransferase sulfotransferase NNP cord-267475-6f4h3cck 1082 11 gene gene NN cord-267475-6f4h3cck 1083 1 The the DT cord-267475-6f4h3cck 1083 2 eyeless eyeless JJ cord-267475-6f4h3cck 1083 3 mouse mouse NN cord-267475-6f4h3cck 1083 4 mutation mutation NN cord-267475-6f4h3cck 1083 5 ( ( -LRB- cord-267475-6f4h3cck 1083 6 ey1 ey1 NNP cord-267475-6f4h3cck 1083 7 ) ) -RRB- cord-267475-6f4h3cck 1083 8 removes remove VBZ cord-267475-6f4h3cck 1083 9 an an DT cord-267475-6f4h3cck 1083 10 alternative alternative JJ cord-267475-6f4h3cck 1083 11 start start NN cord-267475-6f4h3cck 1083 12 codon codon NN cord-267475-6f4h3cck 1083 13 from from IN cord-267475-6f4h3cck 1083 14 the the DT cord-267475-6f4h3cck 1083 15 Rx Rx NNP cord-267475-6f4h3cck 1083 16 / / SYM cord-267475-6f4h3cck 1083 17 rax rax NNP cord-267475-6f4h3cck 1083 18 homeobox homeobox NNP cord-267475-6f4h3cck 1083 19 gene gene NN cord-267475-6f4h3cck 1083 20 Expression expression NN cord-267475-6f4h3cck 1083 21 patterns pattern NNS cord-267475-6f4h3cck 1083 22 of of IN cord-267475-6f4h3cck 1083 23 the the DT cord-267475-6f4h3cck 1083 24 multiple multiple JJ cord-267475-6f4h3cck 1083 25 transcripts transcript NNS cord-267475-6f4h3cck 1083 26 from from IN cord-267475-6f4h3cck 1083 27 the the DT cord-267475-6f4h3cck 1083 28 folylpolyglutamate folylpolyglutamate NNP cord-267475-6f4h3cck 1083 29 synthetase synthetase NN cord-267475-6f4h3cck 1083 30 gene gene NN cord-267475-6f4h3cck 1083 31 in in IN cord-267475-6f4h3cck 1083 32 human human JJ cord-267475-6f4h3cck 1083 33 leukemias leukemia NNS cord-267475-6f4h3cck 1083 34 and and CC cord-267475-6f4h3cck 1083 35 normal normal JJ cord-267475-6f4h3cck 1083 36 differentiated differentiated JJ cord-267475-6f4h3cck 1083 37 tissues tissue NNS cord-267475-6f4h3cck 1084 1 Ataxia Ataxia NNP cord-267475-6f4h3cck 1084 2 caused cause VBN cord-267475-6f4h3cck 1084 3 by by IN cord-267475-6f4h3cck 1084 4 mutations mutation NNS cord-267475-6f4h3cck 1084 5 in in IN cord-267475-6f4h3cck 1084 6 the the DT cord-267475-6f4h3cck 1084 7 atocopherol atocopherol NNP cord-267475-6f4h3cck 1084 8 transfer transfer NN cord-267475-6f4h3cck 1084 9 protein protein NN cord-267475-6f4h3cck 1084 10 gene gene NN cord-267475-6f4h3cck 1084 11 Mutations Mutations NNPS cord-267475-6f4h3cck 1084 12 in in IN cord-267475-6f4h3cck 1084 13 each each DT cord-267475-6f4h3cck 1084 14 of of IN cord-267475-6f4h3cck 1084 15 the the DT cord-267475-6f4h3cck 1084 16 five five CD cord-267475-6f4h3cck 1084 17 subunits subunit NNS cord-267475-6f4h3cck 1084 18 of of IN cord-267475-6f4h3cck 1084 19 translation translation NN cord-267475-6f4h3cck 1084 20 initiation initiation NN cord-267475-6f4h3cck 1084 21 factor factor NN cord-267475-6f4h3cck 1084 22 eIF2B eif2b CC cord-267475-6f4h3cck 1084 23 can can MD cord-267475-6f4h3cck 1084 24 cause cause VB cord-267475-6f4h3cck 1084 25 leukoencephalopathy leukoencephalopathy NNP cord-267475-6f4h3cck 1084 26 with with IN cord-267475-6f4h3cck 1084 27 vanishing vanish VBG cord-267475-6f4h3cck 1084 28 white white JJ cord-267475-6f4h3cck 1084 29 matter matter NN cord-267475-6f4h3cck 1084 30 Structural structural JJ cord-267475-6f4h3cck 1084 31 and and CC cord-267475-6f4h3cck 1084 32 functional functional JJ cord-267475-6f4h3cck 1084 33 genomics genomic NNS cord-267475-6f4h3cck 1084 34 of of IN cord-267475-6f4h3cck 1084 35 the the DT cord-267475-6f4h3cck 1084 36 CPT1B cpt1b CD cord-267475-6f4h3cck 1084 37 gene gene NN cord-267475-6f4h3cck 1084 38 for for IN cord-267475-6f4h3cck 1084 39 muscle muscle NN cord-267475-6f4h3cck 1084 40 - - HYPH cord-267475-6f4h3cck 1084 41 type type NN cord-267475-6f4h3cck 1084 42 carnitine carnitine NN cord-267475-6f4h3cck 1085 1 palmitoyltransferase palmitoyltransferase NNP cord-267475-6f4h3cck 1086 1 I -PRON- PRP cord-267475-6f4h3cck 1086 2 in in IN cord-267475-6f4h3cck 1086 3 mammals mammal NNS cord-267475-6f4h3cck 1086 4 Ribosomal Ribosomal NNP cord-267475-6f4h3cck 1086 5 scanning scan VBG cord-267475-6f4h3cck 1086 6 on on IN cord-267475-6f4h3cck 1086 7 the the DT cord-267475-6f4h3cck 1086 8 highly highly RB cord-267475-6f4h3cck 1086 9 structured structured JJ cord-267475-6f4h3cck 1086 10 insulin insulin NN cord-267475-6f4h3cck 1086 11 - - HYPH cord-267475-6f4h3cck 1086 12 like like JJ cord-267475-6f4h3cck 1086 13 growth growth NN cord-267475-6f4h3cck 1086 14 factor factor NN cord-267475-6f4h3cck 1086 15 II II NNP cord-267475-6f4h3cck 1086 16 - - HYPH cord-267475-6f4h3cck 1086 17 leader leader NN cord-267475-6f4h3cck 1086 18 1 1 CD cord-267475-6f4h3cck 1086 19 Opposing oppose VBG cord-267475-6f4h3cck 1086 20 roles role NNS cord-267475-6f4h3cck 1086 21 of of IN cord-267475-6f4h3cck 1086 22 Elk-1 Elk-1 NNP cord-267475-6f4h3cck 1086 23 and and CC cord-267475-6f4h3cck 1086 24 its -PRON- PRP$ cord-267475-6f4h3cck 1086 25 brain brain NN cord-267475-6f4h3cck 1086 26 - - HYPH cord-267475-6f4h3cck 1086 27 specific specific JJ cord-267475-6f4h3cck 1086 28 isoform isoform NN cord-267475-6f4h3cck 1086 29 , , , cord-267475-6f4h3cck 1086 30 short short JJ cord-267475-6f4h3cck 1086 31 elk-1 elk-1 NNP cord-267475-6f4h3cck 1086 32 , , , cord-267475-6f4h3cck 1086 33 in in IN cord-267475-6f4h3cck 1086 34 nerve nerve NN cord-267475-6f4h3cck 1086 35 growth growth NN cord-267475-6f4h3cck 1086 36 factor factor NN cord-267475-6f4h3cck 1086 37 - - HYPH cord-267475-6f4h3cck 1086 38 induced induce VBN cord-267475-6f4h3cck 1086 39 PC12 pc12 JJ cord-267475-6f4h3cck 1086 40 differentiation differentiation NN cord-267475-6f4h3cck 1086 41 Identification identification NN cord-267475-6f4h3cck 1086 42 of of IN cord-267475-6f4h3cck 1086 43 Rauscher Rauscher NNP cord-267475-6f4h3cck 1086 44 murine murine JJ cord-267475-6f4h3cck 1086 45 leukemia leukemia NN cord-267475-6f4h3cck 1086 46 virus virus NN cord-267475-6f4h3cck 1086 47 - - : cord-267475-6f4h3cck 1086 48 specific specific JJ cord-267475-6f4h3cck 1086 49 mRNAs mRNAs NNPS cord-267475-6f4h3cck 1086 50 for for IN cord-267475-6f4h3cck 1086 51 the the DT cord-267475-6f4h3cck 1086 52 synthesis synthesis NN cord-267475-6f4h3cck 1086 53 of of IN cord-267475-6f4h3cck 1086 54 gag gag NN cord-267475-6f4h3cck 1086 55 - - HYPH cord-267475-6f4h3cck 1086 56 and and CC cord-267475-6f4h3cck 1086 57 env env NN cord-267475-6f4h3cck 1086 58 - - HYPH cord-267475-6f4h3cck 1086 59 gene gene NN cord-267475-6f4h3cck 1086 60 products product NNS cord-267475-6f4h3cck 1086 61 In in IN cord-267475-6f4h3cck 1086 62 vivo vivo NN cord-267475-6f4h3cck 1086 63 translation translation NN cord-267475-6f4h3cck 1086 64 of of IN cord-267475-6f4h3cck 1086 65 the the DT cord-267475-6f4h3cck 1086 66 triple triple JJ cord-267475-6f4h3cck 1086 67 gene gene NN cord-267475-6f4h3cck 1086 68 block block NN cord-267475-6f4h3cck 1086 69 of of IN cord-267475-6f4h3cck 1086 70 potato potato NN cord-267475-6f4h3cck 1086 71 virus virus NN cord-267475-6f4h3cck 1086 72 X x NN cord-267475-6f4h3cck 1086 73 requires require VBZ cord-267475-6f4h3cck 1086 74 two two CD cord-267475-6f4h3cck 1086 75 subgenomic subgenomic JJ cord-267475-6f4h3cck 1086 76 mRNAs mRNAs NNPS cord-267475-6f4h3cck 1087 1 The the DT cord-267475-6f4h3cck 1087 2 yeast yeast NN cord-267475-6f4h3cck 1087 3 transcription transcription NN cord-267475-6f4h3cck 1087 4 factor factor NN cord-267475-6f4h3cck 1087 5 genes gene NNS cord-267475-6f4h3cck 1087 6 YAP1 YAP1 NNP cord-267475-6f4h3cck 1087 7 and and CC cord-267475-6f4h3cck 1087 8 YAP2 YAP2 NNP cord-267475-6f4h3cck 1087 9 are be VBP cord-267475-6f4h3cck 1087 10 subject subject JJ cord-267475-6f4h3cck 1087 11 to to IN cord-267475-6f4h3cck 1087 12 differential differential JJ cord-267475-6f4h3cck 1087 13 control control NN cord-267475-6f4h3cck 1087 14 at at IN cord-267475-6f4h3cck 1087 15 the the DT cord-267475-6f4h3cck 1087 16 levels level NNS cord-267475-6f4h3cck 1087 17 of of IN cord-267475-6f4h3cck 1087 18 both both DT cord-267475-6f4h3cck 1087 19 translation translation NN cord-267475-6f4h3cck 1087 20 and and CC cord-267475-6f4h3cck 1087 21 mRNA mRNA NNP cord-267475-6f4h3cck 1087 22 stability stability NN cord-267475-6f4h3cck 1087 23 Rejection Rejection NNP cord-267475-6f4h3cck 1087 24 antigen antigen NN cord-267475-6f4h3cck 1087 25 peptides peptide NNS cord-267475-6f4h3cck 1087 26 on on IN cord-267475-6f4h3cck 1087 27 BALB BALB NNP cord-267475-6f4h3cck 1087 28 / / SYM cord-267475-6f4h3cck 1087 29 c c NNP cord-267475-6f4h3cck 1087 30 RLF1 RLF1 NNP cord-267475-6f4h3cck 1087 31 leukemia leukemia NN cord-267475-6f4h3cck 1087 32 recognized recognize VBN cord-267475-6f4h3cck 1087 33 by by IN cord-267475-6f4h3cck 1087 34 cytotoxic cytotoxic JJ cord-267475-6f4h3cck 1087 35 T t NN cord-267475-6f4h3cck 1087 36 lymphocytes lymphocyte NNS cord-267475-6f4h3cck 1087 37 : : : cord-267475-6f4h3cck 1088 1 derivation derivation NN cord-267475-6f4h3cck 1088 2 from from IN cord-267475-6f4h3cck 1088 3 the the DT cord-267475-6f4h3cck 1088 4 normally normally RB cord-267475-6f4h3cck 1088 5 untranslated untranslate VBN cord-267475-6f4h3cck 1088 6 5 5 CD cord-267475-6f4h3cck 1088 7 0 0 CD cord-267475-6f4h3cck 1088 8 region region NN cord-267475-6f4h3cck 1088 9 of of IN cord-267475-6f4h3cck 1088 10 the the DT cord-267475-6f4h3cck 1088 11 c c NNP cord-267475-6f4h3cck 1088 12 - - HYPH cord-267475-6f4h3cck 1088 13 Akt Akt NNP cord-267475-6f4h3cck 1088 14 proto proto JJ cord-267475-6f4h3cck 1088 15 - - HYPH cord-267475-6f4h3cck 1088 16 oncogene oncogene NN cord-267475-6f4h3cck 1088 17 activated activate VBN cord-267475-6f4h3cck 1088 18 by by IN cord-267475-6f4h3cck 1088 19 long long JJ cord-267475-6f4h3cck 1088 20 terminal terminal NN cord-267475-6f4h3cck 1088 21 repeat repeat NN cord-267475-6f4h3cck 1088 22 Genomic genomic JJ cord-267475-6f4h3cck 1088 23 architecture architecture NN cord-267475-6f4h3cck 1088 24 and and CC cord-267475-6f4h3cck 1088 25 transcriptional transcriptional JJ cord-267475-6f4h3cck 1088 26 activation activation NN cord-267475-6f4h3cck 1088 27 of of IN cord-267475-6f4h3cck 1088 28 the the DT cord-267475-6f4h3cck 1088 29 mouse mouse NN cord-267475-6f4h3cck 1088 30 and and CC cord-267475-6f4h3cck 1088 31 human human JJ cord-267475-6f4h3cck 1088 32 tumor tumor NN cord-267475-6f4h3cck 1088 33 susceptibility susceptibility NN cord-267475-6f4h3cck 1088 34 gene gene NN cord-267475-6f4h3cck 1088 35 TSG101 TSG101 NNP cord-267475-6f4h3cck 1088 36 : : : cord-267475-6f4h3cck 1088 37 common common JJ cord-267475-6f4h3cck 1088 38 types type NNS cord-267475-6f4h3cck 1088 39 of of IN cord-267475-6f4h3cck 1088 40 shorter short JJR cord-267475-6f4h3cck 1088 41 transcripts transcript NNS cord-267475-6f4h3cck 1088 42 are be VBP cord-267475-6f4h3cck 1088 43 true true JJ cord-267475-6f4h3cck 1088 44 alternative alternative JJ cord-267475-6f4h3cck 1088 45 splice splice NN cord-267475-6f4h3cck 1088 46 variants variant NNS cord-267475-6f4h3cck 1089 1 A a DT cord-267475-6f4h3cck 1089 2 human human JJ cord-267475-6f4h3cck 1089 3 aminoacyl aminoacyl NNP cord-267475-6f4h3cck 1089 4 - - HYPH cord-267475-6f4h3cck 1089 5 tRNA trna NN cord-267475-6f4h3cck 1089 6 synthetase synthetase NN cord-267475-6f4h3cck 1089 7 as as IN cord-267475-6f4h3cck 1089 8 a a DT cord-267475-6f4h3cck 1089 9 regulator regulator NN cord-267475-6f4h3cck 1089 10 of of IN cord-267475-6f4h3cck 1089 11 angiogenesis angiogenesis NN cord-267475-6f4h3cck 1089 12 Analysis Analysis NNP cord-267475-6f4h3cck 1089 13 of of IN cord-267475-6f4h3cck 1089 14 the the DT cord-267475-6f4h3cck 1089 15 two two CD cord-267475-6f4h3cck 1089 16 subgenomic subgenomic NNP cord-267475-6f4h3cck 1089 17 RNA RNA NNP cord-267475-6f4h3cck 1089 18 promoters promoter NNS cord-267475-6f4h3cck 1089 19 for for IN cord-267475-6f4h3cck 1089 20 turnip turnip NN cord-267475-6f4h3cck 1089 21 crinkle crinkle NN cord-267475-6f4h3cck 1089 22 virus virus NN cord-267475-6f4h3cck 1089 23 in in IN cord-267475-6f4h3cck 1089 24 vivo vivo NN cord-267475-6f4h3cck 1089 25 and and CC cord-267475-6f4h3cck 1089 26 in in IN cord-267475-6f4h3cck 1089 27 vitro vitro FW cord-267475-6f4h3cck 1089 28 Inefficient inefficient JJ cord-267475-6f4h3cck 1089 29 reinitiation reinitiation NN cord-267475-6f4h3cck 1089 30 is be VBZ cord-267475-6f4h3cck 1089 31 responsible responsible JJ cord-267475-6f4h3cck 1089 32 for for IN cord-267475-6f4h3cck 1089 33 upstream upstream JJ cord-267475-6f4h3cck 1089 34 open open JJ cord-267475-6f4h3cck 1089 35 reading reading NN cord-267475-6f4h3cck 1089 36 frame frame NN cord-267475-6f4h3cck 1089 37 - - HYPH cord-267475-6f4h3cck 1089 38 mediated mediate VBN cord-267475-6f4h3cck 1089 39 translational translational JJ cord-267475-6f4h3cck 1089 40 repression repression NN cord-267475-6f4h3cck 1089 41 of of IN cord-267475-6f4h3cck 1089 42 the the DT cord-267475-6f4h3cck 1089 43 maize maize NN cord-267475-6f4h3cck 1089 44 R r NN cord-267475-6f4h3cck 1089 45 gene gene NN cord-267475-6f4h3cck 1089 46 Role role NN cord-267475-6f4h3cck 1089 47 of of IN cord-267475-6f4h3cck 1089 48 mRNA mRNA NNP cord-267475-6f4h3cck 1089 49 secondary secondary JJ cord-267475-6f4h3cck 1089 50 structure structure NN cord-267475-6f4h3cck 1089 51 in in IN cord-267475-6f4h3cck 1089 52 translational translational JJ cord-267475-6f4h3cck 1089 53 repression repression NN cord-267475-6f4h3cck 1089 54 of of IN cord-267475-6f4h3cck 1089 55 the the DT cord-267475-6f4h3cck 1089 56 maize maize NN cord-267475-6f4h3cck 1089 57 transcriptional transcriptional NN cord-267475-6f4h3cck 1089 58 activator activator NN cord-267475-6f4h3cck 1089 59 Lc Lc NNP cord-267475-6f4h3cck 1089 60 Utilization Utilization NNP cord-267475-6f4h3cck 1089 61 of of IN cord-267475-6f4h3cck 1089 62 an an DT cord-267475-6f4h3cck 1089 63 alternative alternative JJ cord-267475-6f4h3cck 1089 64 open open JJ cord-267475-6f4h3cck 1089 65 reading reading NN cord-267475-6f4h3cck 1089 66 frame frame NN cord-267475-6f4h3cck 1089 67 of of IN cord-267475-6f4h3cck 1089 68 a a DT cord-267475-6f4h3cck 1089 69 normal normal JJ cord-267475-6f4h3cck 1089 70 gene gene NN cord-267475-6f4h3cck 1089 71 in in IN cord-267475-6f4h3cck 1089 72 generating generate VBG cord-267475-6f4h3cck 1089 73 a a DT cord-267475-6f4h3cck 1089 74 novel novel JJ cord-267475-6f4h3cck 1089 75 human human JJ cord-267475-6f4h3cck 1089 76 cancer cancer NN cord-267475-6f4h3cck 1089 77 antigen antigen NN cord-267475-6f4h3cck 1089 78 Post post JJ cord-267475-6f4h3cck 1089 79 - - JJ cord-267475-6f4h3cck 1089 80 transcriptional transcriptional JJ cord-267475-6f4h3cck 1089 81 regulation regulation NN cord-267475-6f4h3cck 1089 82 of of IN cord-267475-6f4h3cck 1089 83 the the DT cord-267475-6f4h3cck 1089 84 GLI1 GLI1 NNP cord-267475-6f4h3cck 1089 85 oncogene oncogene NN cord-267475-6f4h3cck 1089 86 by by IN cord-267475-6f4h3cck 1089 87 the the DT cord-267475-6f4h3cck 1089 88 expression expression NN cord-267475-6f4h3cck 1089 89 of of IN cord-267475-6f4h3cck 1089 90 alternative alternative JJ cord-267475-6f4h3cck 1089 91 5 5 CD cord-267475-6f4h3cck 1089 92 0 0 CD cord-267475-6f4h3cck 1089 93 untranslated untranslated JJ cord-267475-6f4h3cck 1089 94 regions region NNS cord-267475-6f4h3cck 1090 1 A a DT cord-267475-6f4h3cck 1090 2 novel novel NN cord-267475-6f4h3cck 1090 3 , , , cord-267475-6f4h3cck 1090 4 testis testis NN cord-267475-6f4h3cck 1090 5 - - HYPH cord-267475-6f4h3cck 1090 6 specific specific JJ cord-267475-6f4h3cck 1090 7 mRNA mRNA NNP cord-267475-6f4h3cck 1090 8 transcript transcript NN cord-267475-6f4h3cck 1090 9 encoding encode VBG cord-267475-6f4h3cck 1090 10 an an DT cord-267475-6f4h3cck 1090 11 NH NH NNP cord-267475-6f4h3cck 1090 12 2 2 CD cord-267475-6f4h3cck 1090 13 -terminal -terminal JJ cord-267475-6f4h3cck 1090 14 truncated truncated JJ cord-267475-6f4h3cck 1090 15 nitric nitric JJ cord-267475-6f4h3cck 1090 16 - - HYPH cord-267475-6f4h3cck 1090 17 oxide oxide NN cord-267475-6f4h3cck 1090 18 synthase synthase NN cord-267475-6f4h3cck 1090 19 RNA RNA NNP cord-267475-6f4h3cck 1090 20 diversity diversity NN cord-267475-6f4h3cck 1090 21 has have VBZ cord-267475-6f4h3cck 1090 22 profound profound JJ cord-267475-6f4h3cck 1090 23 effects effect NNS cord-267475-6f4h3cck 1090 24 on on IN cord-267475-6f4h3cck 1090 25 the the DT cord-267475-6f4h3cck 1090 26 translation translation NN cord-267475-6f4h3cck 1090 27 of of IN cord-267475-6f4h3cck 1090 28 neuronal neuronal JJ cord-267475-6f4h3cck 1090 29 nitric nitric NN cord-267475-6f4h3cck 1090 30 oxide oxide NN cord-267475-6f4h3cck 1090 31 synthase synthase NN cord-267475-6f4h3cck 1090 32 Bunyamwera Bunyamwera NNP cord-267475-6f4h3cck 1090 33 bunyavirus bunyavirus NN cord-267475-6f4h3cck 1090 34 nonstructural nonstructural JJ cord-267475-6f4h3cck 1090 35 protein protein NN cord-267475-6f4h3cck 1090 36 NSs NSs NNP cord-267475-6f4h3cck 1090 37 counteracts counteract VBZ cord-267475-6f4h3cck 1090 38 the the DT cord-267475-6f4h3cck 1090 39 induction induction NN cord-267475-6f4h3cck 1090 40 of of IN cord-267475-6f4h3cck 1090 41 alpha alpha NN cord-267475-6f4h3cck 1090 42 / / SYM cord-267475-6f4h3cck 1090 43 beta beta NN cord-267475-6f4h3cck 1090 44 interferon interferon NNP cord-267475-6f4h3cck 1090 45 Genomic Genomic NNP cord-267475-6f4h3cck 1090 46 organization organization NN cord-267475-6f4h3cck 1090 47 of of IN cord-267475-6f4h3cck 1090 48 human human NNP cord-267475-6f4h3cck 1090 49 MXI1 MXI1 NNP cord-267475-6f4h3cck 1090 50 , , , cord-267475-6f4h3cck 1091 1 a a DT cord-267475-6f4h3cck 1091 2 putative putative JJ cord-267475-6f4h3cck 1091 3 tumor tumor NN cord-267475-6f4h3cck 1091 4 suppressor suppressor NN cord-267475-6f4h3cck 1091 5 gene gene NN cord-267475-6f4h3cck 1091 6 Acquired acquire VBN cord-267475-6f4h3cck 1091 7 mutations mutation NNS cord-267475-6f4h3cck 1091 8 in in IN cord-267475-6f4h3cck 1091 9 GATA1 gata1 CD cord-267475-6f4h3cck 1091 10 in in IN cord-267475-6f4h3cck 1091 11 the the DT cord-267475-6f4h3cck 1091 12 megakaryoblastic megakaryoblastic JJ cord-267475-6f4h3cck 1091 13 leukemia leukemia NN cord-267475-6f4h3cck 1091 14 of of IN cord-267475-6f4h3cck 1091 15 Down Down NNP cord-267475-6f4h3cck 1091 16 syndrome syndrome NN cord-267475-6f4h3cck 1091 17 Infectious Infectious NNP cord-267475-6f4h3cck 1091 18 TYMV TYMV NNP cord-267475-6f4h3cck 1091 19 RNA RNA NNP cord-267475-6f4h3cck 1091 20 from from IN cord-267475-6f4h3cck 1091 21 cloned clone VBN cord-267475-6f4h3cck 1091 22 cDNA cdna NN cord-267475-6f4h3cck 1091 23 : : : cord-267475-6f4h3cck 1091 24 effects effect NNS cord-267475-6f4h3cck 1091 25 in in IN cord-267475-6f4h3cck 1091 26 vitro vitro FW cord-267475-6f4h3cck 1091 27 and and CC cord-267475-6f4h3cck 1091 28 in in IN cord-267475-6f4h3cck 1091 29 vivo vivo NN cord-267475-6f4h3cck 1091 30 of of IN cord-267475-6f4h3cck 1091 31 point point NN cord-267475-6f4h3cck 1091 32 substitutions substitution NNS cord-267475-6f4h3cck 1091 33 in in IN cord-267475-6f4h3cck 1091 34 the the DT cord-267475-6f4h3cck 1091 35 initiation initiation NN cord-267475-6f4h3cck 1091 36 codons codon NNS cord-267475-6f4h3cck 1091 37 of of IN cord-267475-6f4h3cck 1091 38 two two CD cord-267475-6f4h3cck 1091 39 extensively extensively RB cord-267475-6f4h3cck 1091 40 overlapping overlap VBG cord-267475-6f4h3cck 1091 41 ORFs orfs JJ cord-267475-6f4h3cck 1091 42 Expression expression NN cord-267475-6f4h3cck 1091 43 of of IN cord-267475-6f4h3cck 1091 44 the the DT cord-267475-6f4h3cck 1091 45 hepatitis hepatitis NN cord-267475-6f4h3cck 1091 46 B B NNP cord-267475-6f4h3cck 1091 47 virus virus NN cord-267475-6f4h3cck 1091 48 core core NN cord-267475-6f4h3cck 1091 49 gene gene NN cord-267475-6f4h3cck 1091 50 in in IN cord-267475-6f4h3cck 1091 51 vitro vitro FW cord-267475-6f4h3cck 1091 52 and and CC cord-267475-6f4h3cck 1091 53 in in IN cord-267475-6f4h3cck 1091 54 vivo vivo NNP cord-267475-6f4h3cck 1091 55 Cytomegalovirus Cytomegalovirus NNP cord-267475-6f4h3cck 1091 56 assembly assembly NN cord-267475-6f4h3cck 1091 57 protein protein NN cord-267475-6f4h3cck 1091 58 nested nest VBD cord-267475-6f4h3cck 1091 59 gene gene NN cord-267475-6f4h3cck 1091 60 family family NN cord-267475-6f4h3cck 1091 61 : : : cord-267475-6f4h3cck 1091 62 four four CD cord-267475-6f4h3cck 1091 63 3 3 CD cord-267475-6f4h3cck 1091 64 0 0 CD cord-267475-6f4h3cck 1092 1 -coterminal -coterminal JJ cord-267475-6f4h3cck 1092 2 transcripts transcript NNS cord-267475-6f4h3cck 1092 3 encode encode VBP cord-267475-6f4h3cck 1092 4 four four CD cord-267475-6f4h3cck 1092 5 in in IN cord-267475-6f4h3cck 1092 6 - - HYPH cord-267475-6f4h3cck 1092 7 frame frame NN cord-267475-6f4h3cck 1092 8 overlapping overlap VBG cord-267475-6f4h3cck 1092 9 proteins protein NNS cord-267475-6f4h3cck 1093 1 An an DT cord-267475-6f4h3cck 1093 2 internal internal JJ cord-267475-6f4h3cck 1093 3 open open JJ cord-267475-6f4h3cck 1093 4 reading reading NN cord-267475-6f4h3cck 1093 5 frame frame NN cord-267475-6f4h3cck 1093 6 triggers trigger VBZ cord-267475-6f4h3cck 1093 7 nonsense nonsense NN cord-267475-6f4h3cck 1093 8 - - HYPH cord-267475-6f4h3cck 1093 9 mediated mediate VBN cord-267475-6f4h3cck 1093 10 decay decay NN cord-267475-6f4h3cck 1093 11 of of IN cord-267475-6f4h3cck 1093 12 the the DT cord-267475-6f4h3cck 1093 13 yeast yeast NN cord-267475-6f4h3cck 1094 1 SPT10 SPT10 NNP cord-267475-6f4h3cck 1095 1 mRNA mRNA NNP cord-267475-6f4h3cck 1095 2 Deregulation deregulation NN cord-267475-6f4h3cck 1095 3 of of IN cord-267475-6f4h3cck 1095 4 translational translational JJ cord-267475-6f4h3cck 1095 5 control control NN cord-267475-6f4h3cck 1095 6 of of IN cord-267475-6f4h3cck 1095 7 the the DT cord-267475-6f4h3cck 1095 8 65-kDa 65-kda CD cord-267475-6f4h3cck 1095 9 regulatory regulatory JJ cord-267475-6f4h3cck 1095 10 subunit subunit NN cord-267475-6f4h3cck 1095 11 ( ( -LRB- cord-267475-6f4h3cck 1095 12 PR65a PR65a NNP cord-267475-6f4h3cck 1095 13 ) ) -RRB- cord-267475-6f4h3cck 1095 14 of of IN cord-267475-6f4h3cck 1095 15 protein protein NN cord-267475-6f4h3cck 1095 16 phosphatase phosphatase NN cord-267475-6f4h3cck 1095 17 2A 2a NN cord-267475-6f4h3cck 1095 18 leads lead VBZ cord-267475-6f4h3cck 1095 19 to to IN cord-267475-6f4h3cck 1095 20 multinucleated multinucleate VBN cord-267475-6f4h3cck 1095 21 cells cell NNS cord-267475-6f4h3cck 1096 1 The the DT cord-267475-6f4h3cck 1096 2 short short JJ cord-267475-6f4h3cck 1096 3 5 5 CD cord-267475-6f4h3cck 1096 4 0 0 CD cord-267475-6f4h3cck 1096 5 untranslated untranslated JJ cord-267475-6f4h3cck 1096 6 region region NN cord-267475-6f4h3cck 1096 7 of of IN cord-267475-6f4h3cck 1096 8 the the DT cord-267475-6f4h3cck 1096 9 betaA3 betaA3 NNS cord-267475-6f4h3cck 1096 10 / / SYM cord-267475-6f4h3cck 1096 11 A1-crystallin A1-crystallin NNP cord-267475-6f4h3cck 1096 12 mRNA mrna NN cord-267475-6f4h3cck 1096 13 is be VBZ cord-267475-6f4h3cck 1096 14 responsible responsible JJ cord-267475-6f4h3cck 1096 15 for for IN cord-267475-6f4h3cck 1096 16 leaky leaky JJ cord-267475-6f4h3cck 1096 17 ribosomal ribosomal NN cord-267475-6f4h3cck 1096 18 scanning scan VBG cord-267475-6f4h3cck 1096 19 The the DT cord-267475-6f4h3cck 1096 20 human human JJ cord-267475-6f4h3cck 1096 21 achaete achaete NN cord-267475-6f4h3cck 1096 22 scute scute NNP cord-267475-6f4h3cck 1096 23 homolog homolog NN cord-267475-6f4h3cck 1096 24 2 2 CD cord-267475-6f4h3cck 1096 25 gene gene NN cord-267475-6f4h3cck 1096 26 contains contain VBZ cord-267475-6f4h3cck 1096 27 two two CD cord-267475-6f4h3cck 1096 28 promoters promoter NNS cord-267475-6f4h3cck 1096 29 , , , cord-267475-6f4h3cck 1096 30 generating generate VBG cord-267475-6f4h3cck 1096 31 overlapping overlap VBG cord-267475-6f4h3cck 1096 32 transcripts transcript NNS cord-267475-6f4h3cck 1096 33 and and CC cord-267475-6f4h3cck 1096 34 encoding encode VBG cord-267475-6f4h3cck 1096 35 two two CD cord-267475-6f4h3cck 1096 36 proteins protein NNS cord-267475-6f4h3cck 1096 37 with with IN cord-267475-6f4h3cck 1096 38 different different JJ cord-267475-6f4h3cck 1096 39 nuclear nuclear JJ cord-267475-6f4h3cck 1096 40 localization localization NN cord-267475-6f4h3cck 1097 1 An an DT cord-267475-6f4h3cck 1097 2 activating activate VBG cord-267475-6f4h3cck 1097 3 splice splice NN cord-267475-6f4h3cck 1097 4 donor donor NN cord-267475-6f4h3cck 1097 5 mutation mutation NN cord-267475-6f4h3cck 1097 6 in in IN cord-267475-6f4h3cck 1097 7 the the DT cord-267475-6f4h3cck 1097 8 thrombopoietin thrombopoietin NNP cord-267475-6f4h3cck 1097 9 gene gene NN cord-267475-6f4h3cck 1097 10 causes cause VBZ cord-267475-6f4h3cck 1097 11 hereditary hereditary JJ cord-267475-6f4h3cck 1097 12 thrombocythaemia thrombocythaemia NN cord-267475-6f4h3cck 1097 13 Cloning cloning NN cord-267475-6f4h3cck 1097 14 and and CC cord-267475-6f4h3cck 1097 15 characterization characterization NN cord-267475-6f4h3cck 1097 16 of of IN cord-267475-6f4h3cck 1097 17 two two CD cord-267475-6f4h3cck 1097 18 novel novel JJ cord-267475-6f4h3cck 1097 19 thyroid thyroid NN cord-267475-6f4h3cck 1097 20 hormone hormone NN cord-267475-6f4h3cck 1097 21 receptor receptor NN cord-267475-6f4h3cck 1097 22 b b NN cord-267475-6f4h3cck 1097 23 isoforms isoform NNS cord-267475-6f4h3cck 1098 1 A a DT cord-267475-6f4h3cck 1098 2 6700 6700 CD cord-267475-6f4h3cck 1098 3 MW mw NN cord-267475-6f4h3cck 1098 4 membrane membrane NN cord-267475-6f4h3cck 1098 5 protein protein NN cord-267475-6f4h3cck 1098 6 is be VBZ cord-267475-6f4h3cck 1098 7 encoded encode VBN cord-267475-6f4h3cck 1098 8 by by IN cord-267475-6f4h3cck 1098 9 region region NN cord-267475-6f4h3cck 1098 10 E3 E3 NNP cord-267475-6f4h3cck 1098 11 of of IN cord-267475-6f4h3cck 1098 12 adenovirus adenovirus NN cord-267475-6f4h3cck 1098 13 type type NN cord-267475-6f4h3cck 1098 14 2 2 CD cord-267475-6f4h3cck 1099 1 The the DT cord-267475-6f4h3cck 1099 2 glyoxysomal glyoxysomal JJ cord-267475-6f4h3cck 1099 3 and and CC cord-267475-6f4h3cck 1099 4 plastid plastid NN cord-267475-6f4h3cck 1099 5 molecular molecular JJ cord-267475-6f4h3cck 1099 6 chaperones chaperone NNS cord-267475-6f4h3cck 1099 7 ( ( -LRB- cord-267475-6f4h3cck 1099 8 70-kDa 70-kda CD cord-267475-6f4h3cck 1099 9 heat heat NN cord-267475-6f4h3cck 1099 10 shock shock NN cord-267475-6f4h3cck 1099 11 protein protein NN cord-267475-6f4h3cck 1099 12 ) ) -RRB- cord-267475-6f4h3cck 1099 13 of of IN cord-267475-6f4h3cck 1099 14 watermelon watermelon NN cord-267475-6f4h3cck 1099 15 cotyledons cotyledon NNS cord-267475-6f4h3cck 1099 16 are be VBP cord-267475-6f4h3cck 1099 17 encoded encode VBN cord-267475-6f4h3cck 1099 18 by by IN cord-267475-6f4h3cck 1099 19 a a DT cord-267475-6f4h3cck 1099 20 single single JJ cord-267475-6f4h3cck 1099 21 gene gene NN cord-267475-6f4h3cck 1099 22 Analysis analysis NN cord-267475-6f4h3cck 1099 23 and and CC cord-267475-6f4h3cck 1099 24 mapping mapping NN cord-267475-6f4h3cck 1099 25 of of IN cord-267475-6f4h3cck 1099 26 a a DT cord-267475-6f4h3cck 1099 27 family family NN cord-267475-6f4h3cck 1099 28 of of IN cord-267475-6f4h3cck 1099 29 3 3 CD cord-267475-6f4h3cck 1099 30 0 0 CD cord-267475-6f4h3cck 1099 31 -coterminal -coterminal JJ cord-267475-6f4h3cck 1099 32 transcripts transcript NNS cord-267475-6f4h3cck 1099 33 containing contain VBG cord-267475-6f4h3cck 1099 34 coding coding NN cord-267475-6f4h3cck 1099 35 sequences sequence NNS cord-267475-6f4h3cck 1099 36 of of IN cord-267475-6f4h3cck 1099 37 human human JJ cord-267475-6f4h3cck 1099 38 cytomegalovirus cytomegalovirus NN cord-267475-6f4h3cck 1099 39 open open JJ cord-267475-6f4h3cck 1099 40 reading reading NN cord-267475-6f4h3cck 1099 41 frames frame NNS cord-267475-6f4h3cck 1099 42 UL93 UL93 NNP cord-267475-6f4h3cck 1099 43 through through IN cord-267475-6f4h3cck 1099 44 UL99 UL99 NNP cord-267475-6f4h3cck 1099 45 Evidence evidence NN cord-267475-6f4h3cck 1099 46 that that IN cord-267475-6f4h3cck 1099 47 AGUAUAUGA AGUAUAUGA NNP cord-267475-6f4h3cck 1099 48 and and CC cord-267475-6f4h3cck 1099 49 CCAAGAUGA CCAAGAUGA NNP cord-267475-6f4h3cck 1099 50 initiate initiate VB cord-267475-6f4h3cck 1099 51 translation translation NN cord-267475-6f4h3cck 1099 52 in in IN cord-267475-6f4h3cck 1099 53 the the DT cord-267475-6f4h3cck 1099 54 same same JJ cord-267475-6f4h3cck 1099 55 mRNA mrna NN cord-267475-6f4h3cck 1099 56 in in IN cord-267475-6f4h3cck 1099 57 region region NN cord-267475-6f4h3cck 1099 58 E3 E3 NNP cord-267475-6f4h3cck 1099 59 of of IN cord-267475-6f4h3cck 1099 60 adenovirus adenovirus NN cord-267475-6f4h3cck 1099 61 E3 E3 NNP cord-267475-6f4h3cck 1099 62 transcription transcription NN cord-267475-6f4h3cck 1099 63 unit unit NN cord-267475-6f4h3cck 1099 64 of of IN cord-267475-6f4h3cck 1099 65 adenovirus adenovirus NN cord-267475-6f4h3cck 1099 66 Interplay interplay NN cord-267475-6f4h3cck 1099 67 of of IN cord-267475-6f4h3cck 1099 68 heterogeneous heterogeneous JJ cord-267475-6f4h3cck 1099 69 transcriptional transcriptional NN cord-267475-6f4h3cck 1100 1 start start VB cord-267475-6f4h3cck 1100 2 sites site NNS cord-267475-6f4h3cck 1100 3 and and CC cord-267475-6f4h3cck 1100 4 translational translational JJ cord-267475-6f4h3cck 1100 5 selection selection NN cord-267475-6f4h3cck 1100 6 of of IN cord-267475-6f4h3cck 1100 7 AUGs aug NNS cord-267475-6f4h3cck 1100 8 dictate dictate VBP cord-267475-6f4h3cck 1100 9 the the DT cord-267475-6f4h3cck 1100 10 production production NN cord-267475-6f4h3cck 1100 11 of of IN cord-267475-6f4h3cck 1100 12 mitochondrial mitochondrial JJ cord-267475-6f4h3cck 1100 13 and and CC cord-267475-6f4h3cck 1100 14 cytosolic cytosolic JJ cord-267475-6f4h3cck 1100 15 / / SYM cord-267475-6f4h3cck 1100 16 nuclear nuclear JJ cord-267475-6f4h3cck 1100 17 tRNA tRNA NNP cord-267475-6f4h3cck 1100 18 nucleotidyltransferase nucleotidyltransferase NNP cord-267475-6f4h3cck 1100 19 form form NN cord-267475-6f4h3cck 1100 20 the the DT cord-267475-6f4h3cck 1100 21 same same JJ cord-267475-6f4h3cck 1100 22 gene gene NN cord-267475-6f4h3cck 1100 23 in in IN cord-267475-6f4h3cck 1100 24 yeast yeast NN cord-267475-6f4h3cck 1100 25 Mechanisms mechanism NNS cord-267475-6f4h3cck 1100 26 leading lead VBG cord-267475-6f4h3cck 1100 27 to to IN cord-267475-6f4h3cck 1100 28 and and CC cord-267475-6f4h3cck 1100 29 the the DT cord-267475-6f4h3cck 1100 30 consequences consequence NNS cord-267475-6f4h3cck 1100 31 of of IN cord-267475-6f4h3cck 1100 32 altering alter VBG cord-267475-6f4h3cck 1100 33 the the DT cord-267475-6f4h3cck 1100 34 normal normal JJ cord-267475-6f4h3cck 1100 35 distribution distribution NN cord-267475-6f4h3cck 1100 36 of of IN cord-267475-6f4h3cck 1100 37 ATP(CTP):tRNA ATP(CTP):tRNA NNP cord-267475-6f4h3cck 1100 38 nucleotidyltransferase nucleotidyltransferase NN cord-267475-6f4h3cck 1100 39 in in IN cord-267475-6f4h3cck 1100 40 yeast yeast NN cord-267475-6f4h3cck 1101 1 The the DT cord-267475-6f4h3cck 1101 2 5 5 CD cord-267475-6f4h3cck 1101 3 0 0 CD cord-267475-6f4h3cck 1101 4 -untranslated -untranslated JJ cord-267475-6f4h3cck 1101 5 region region NN cord-267475-6f4h3cck 1101 6 of of IN cord-267475-6f4h3cck 1101 7 the the DT cord-267475-6f4h3cck 1101 8 N n CD cord-267475-6f4h3cck 1101 9 - - HYPH cord-267475-6f4h3cck 1101 10 methyl methyl NN cord-267475-6f4h3cck 1101 11 - - HYPH cord-267475-6f4h3cck 1101 12 D d NN cord-267475-6f4h3cck 1101 13 - - HYPH cord-267475-6f4h3cck 1101 14 aspartate aspartate NN cord-267475-6f4h3cck 1101 15 receptor receptor NN cord-267475-6f4h3cck 1101 16 NR2A NR2A NNP cord-267475-6f4h3cck 1101 17 subunit subunit NN cord-267475-6f4h3cck 1101 18 controls control VBZ cord-267475-6f4h3cck 1101 19 efficiency efficiency NN cord-267475-6f4h3cck 1101 20 of of IN cord-267475-6f4h3cck 1101 21 translation translation NN cord-267475-6f4h3cck 1101 22 Characterization characterization NN cord-267475-6f4h3cck 1101 23 of of IN cord-267475-6f4h3cck 1101 24 an an DT cord-267475-6f4h3cck 1101 25 upstream upstream JJ cord-267475-6f4h3cck 1101 26 open open JJ cord-267475-6f4h3cck 1101 27 reading reading NN cord-267475-6f4h3cck 1101 28 frame frame NN cord-267475-6f4h3cck 1101 29 in in IN cord-267475-6f4h3cck 1101 30 the the DT cord-267475-6f4h3cck 1101 31 5 5 CD cord-267475-6f4h3cck 1101 32 0 0 CD cord-267475-6f4h3cck 1101 33 untranslated untranslated JJ cord-267475-6f4h3cck 1101 34 region region NN cord-267475-6f4h3cck 1101 35 of of IN cord-267475-6f4h3cck 1101 36 PR-39 PR-39 NNP cord-267475-6f4h3cck 1101 37 , , , cord-267475-6f4h3cck 1101 38 a a DT cord-267475-6f4h3cck 1101 39 cathelicidin cathelicidin NNP cord-267475-6f4h3cck 1101 40 antimicrobial antimicrobial NN cord-267475-6f4h3cck 1101 41 peptide peptide NN cord-267475-6f4h3cck 1101 42 Identification identification NN cord-267475-6f4h3cck 1101 43 and and CC cord-267475-6f4h3cck 1101 44 characterization characterization NN cord-267475-6f4h3cck 1101 45 of of IN cord-267475-6f4h3cck 1101 46 a a DT cord-267475-6f4h3cck 1101 47 new new JJ cord-267475-6f4h3cck 1101 48 mammalian mammalian JJ cord-267475-6f4h3cck 1101 49 mitogen mitogen NN cord-267475-6f4h3cck 1101 50 - - HYPH cord-267475-6f4h3cck 1101 51 activated activate VBN cord-267475-6f4h3cck 1101 52 protein protein NN cord-267475-6f4h3cck 1101 53 kinase kinase NN cord-267475-6f4h3cck 1101 54 kinase kinase NN cord-267475-6f4h3cck 1101 55 , , , cord-267475-6f4h3cck 1101 56 MKK2 MKK2 NNP cord-267475-6f4h3cck 1101 57 Alternative alternative JJ cord-267475-6f4h3cck 1101 58 transcriptional transcriptional JJ cord-267475-6f4h3cck 1101 59 initiation initiation NN cord-267475-6f4h3cck 1101 60 as as IN cord-267475-6f4h3cck 1101 61 a a DT cord-267475-6f4h3cck 1101 62 novel novel JJ cord-267475-6f4h3cck 1101 63 mechanism mechanism NN cord-267475-6f4h3cck 1101 64 for for IN cord-267475-6f4h3cck 1101 65 regulating regulate VBG cord-267475-6f4h3cck 1101 66 expression expression NN cord-267475-6f4h3cck 1101 67 of of IN cord-267475-6f4h3cck 1101 68 a a DT cord-267475-6f4h3cck 1101 69 baculovirus baculovirus NNP cord-267475-6f4h3cck 1101 70 trans trans NNP cord-267475-6f4h3cck 1101 71 activator activator NN cord-267475-6f4h3cck 1101 72 Expression Expression NNP cord-267475-6f4h3cck 1101 73 of of IN cord-267475-6f4h3cck 1101 74 a a DT cord-267475-6f4h3cck 1101 75 mitogen mitogen NN cord-267475-6f4h3cck 1101 76 - - HYPH cord-267475-6f4h3cck 1101 77 responsive responsive JJ cord-267475-6f4h3cck 1101 78 gene gene NN cord-267475-6f4h3cck 1101 79 encoding encoding NN cord-267475-6f4h3cck 1102 1 prostaglandin prostaglandin NN cord-267475-6f4h3cck 1102 2 synthase synthase NN cord-267475-6f4h3cck 1102 3 is be VBZ cord-267475-6f4h3cck 1102 4 regulated regulate VBN cord-267475-6f4h3cck 1102 5 by by IN cord-267475-6f4h3cck 1102 6 mRNA mrna NN cord-267475-6f4h3cck 1102 7 splicing splice VBG cord-267475-6f4h3cck 1102 8 Inhibition Inhibition NNP cord-267475-6f4h3cck 1102 9 of of IN cord-267475-6f4h3cck 1102 10 corticotropin corticotropin NNP cord-267475-6f4h3cck 1102 11 releasing release VBG cord-267475-6f4h3cck 1102 12 hormone hormone NN cord-267475-6f4h3cck 1102 13 type-1 type-1 NNP cord-267475-6f4h3cck 1102 14 receptor receptor NN cord-267475-6f4h3cck 1102 15 translation translation NN cord-267475-6f4h3cck 1102 16 by by IN cord-267475-6f4h3cck 1102 17 an an DT cord-267475-6f4h3cck 1102 18 upstream upstream JJ cord-267475-6f4h3cck 1102 19 AUG AUG NNP cord-267475-6f4h3cck 1102 20 triplet triplet NN cord-267475-6f4h3cck 1102 21 in in IN cord-267475-6f4h3cck 1102 22 the the DT cord-267475-6f4h3cck 1102 23 5 5 CD cord-267475-6f4h3cck 1102 24 0 0 CD cord-267475-6f4h3cck 1102 25 untranslated untranslated JJ cord-267475-6f4h3cck 1102 26 region region NN cord-267475-6f4h3cck 1103 1 CCAAT/ ccaat/ JJ cord-267475-6f4h3cck 1103 2 enhancer enhancer NN cord-267475-6f4h3cck 1103 3 binding bind VBG cord-267475-6f4h3cck 1103 4 protein protein NN cord-267475-6f4h3cck 1103 5 1 1 CD cord-267475-6f4h3cck 1103 6 is be VBZ cord-267475-6f4h3cck 1103 7 preferentially preferentially RB cord-267475-6f4h3cck 1103 8 up up RB cord-267475-6f4h3cck 1103 9 - - HYPH cord-267475-6f4h3cck 1103 10 regulated regulate VBN cord-267475-6f4h3cck 1103 11 during during IN cord-267475-6f4h3cck 1103 12 granulocyte granulocyte NN cord-267475-6f4h3cck 1103 13 differentiation differentiation NN cord-267475-6f4h3cck 1103 14 and and CC cord-267475-6f4h3cck 1103 15 its -PRON- PRP$ cord-267475-6f4h3cck 1103 16 functional functional JJ cord-267475-6f4h3cck 1103 17 versatility versatility NN cord-267475-6f4h3cck 1103 18 is be VBZ cord-267475-6f4h3cck 1103 19 determined determine VBN cord-267475-6f4h3cck 1103 20 by by IN cord-267475-6f4h3cck 1103 21 alternative alternative JJ cord-267475-6f4h3cck 1103 22 use use NN cord-267475-6f4h3cck 1103 23 of of IN cord-267475-6f4h3cck 1103 24 promoters promoter NNS cord-267475-6f4h3cck 1103 25 and and CC cord-267475-6f4h3cck 1103 26 differential differential JJ cord-267475-6f4h3cck 1103 27 splicing splicing NN cord-267475-6f4h3cck 1103 28 Identification identification NN cord-267475-6f4h3cck 1103 29 of of IN cord-267475-6f4h3cck 1103 30 the the DT cord-267475-6f4h3cck 1103 31 start start NN cord-267475-6f4h3cck 1103 32 sites site NNS cord-267475-6f4h3cck 1103 33 for for IN cord-267475-6f4h3cck 1103 34 the the DT cord-267475-6f4h3cck 1103 35 1.9-and 1.9-and CD cord-267475-6f4h3cck 1103 36 1.4-kb 1.4-kb CD cord-267475-6f4h3cck 1103 37 rat rat NN cord-267475-6f4h3cck 1103 38 transforming transform VBG cord-267475-6f4h3cck 1103 39 growth growth NN cord-267475-6f4h3cck 1103 40 factor factor NN cord-267475-6f4h3cck 1103 41 - - HYPH cord-267475-6f4h3cck 1103 42 b1 b1 NN cord-267475-6f4h3cck 1103 43 transcripts transcript NNS cord-267475-6f4h3cck 1103 44 and and CC cord-267475-6f4h3cck 1103 45 their -PRON- PRP$ cord-267475-6f4h3cck 1103 46 effect effect NN cord-267475-6f4h3cck 1103 47 on on IN cord-267475-6f4h3cck 1103 48 translational translational JJ cord-267475-6f4h3cck 1103 49 efficiency efficiency NN cord-267475-6f4h3cck 1103 50 DNA dna NN cord-267475-6f4h3cck 1103 51 methylation methylation NN cord-267475-6f4h3cck 1103 52 represses repress VBZ cord-267475-6f4h3cck 1103 53 the the DT cord-267475-6f4h3cck 1103 54 expression expression NN cord-267475-6f4h3cck 1103 55 of of IN cord-267475-6f4h3cck 1103 56 the the DT cord-267475-6f4h3cck 1103 57 human human JJ cord-267475-6f4h3cck 1103 58 erythropoietin erythropoietin NN cord-267475-6f4h3cck 1103 59 gene gene NN cord-267475-6f4h3cck 1103 60 by by IN cord-267475-6f4h3cck 1103 61 two two CD cord-267475-6f4h3cck 1103 62 different different JJ cord-267475-6f4h3cck 1103 63 mechanisms mechanism NNS cord-267475-6f4h3cck 1104 1 An an DT cord-267475-6f4h3cck 1104 2 ERCC1 ercc1 NN cord-267475-6f4h3cck 1104 3 splicing splicing NN cord-267475-6f4h3cck 1104 4 variant variant NN cord-267475-6f4h3cck 1104 5 involving involve VBG cord-267475-6f4h3cck 1104 6 the the DT cord-267475-6f4h3cck 1104 7 5 5 CD cord-267475-6f4h3cck 1104 8 0 0 CD cord-267475-6f4h3cck 1104 9 -UTR -utr NN cord-267475-6f4h3cck 1104 10 of of IN cord-267475-6f4h3cck 1104 11 the the DT cord-267475-6f4h3cck 1104 12 mRNA mRNA NNP cord-267475-6f4h3cck 1104 13 may may MD cord-267475-6f4h3cck 1104 14 have have VB cord-267475-6f4h3cck 1104 15 a a DT cord-267475-6f4h3cck 1104 16 transcriptional transcriptional JJ cord-267475-6f4h3cck 1104 17 modulatory modulatory JJ cord-267475-6f4h3cck 1104 18 function function NN cord-267475-6f4h3cck 1104 19 Molecular molecular JJ cord-267475-6f4h3cck 1104 20 identification identification NN cord-267475-6f4h3cck 1104 21 and and CC cord-267475-6f4h3cck 1104 22 characterization characterization NN cord-267475-6f4h3cck 1104 23 of of IN cord-267475-6f4h3cck 1104 24 A a NN cord-267475-6f4h3cck 1104 25 and and CC cord-267475-6f4h3cck 1104 26 B b NN cord-267475-6f4h3cck 1104 27 forms form NNS cord-267475-6f4h3cck 1104 28 of of IN cord-267475-6f4h3cck 1104 29 the the DT cord-267475-6f4h3cck 1104 30 glucocorticoid glucocorticoid NN cord-267475-6f4h3cck 1104 31 receptor receptor NN cord-267475-6f4h3cck 1104 32 Evidence evidence NN cord-267475-6f4h3cck 1104 33 that that IN cord-267475-6f4h3cck 1104 34 a a DT cord-267475-6f4h3cck 1104 35 regulatory regulatory JJ cord-267475-6f4h3cck 1104 36 gene gene NN cord-267475-6f4h3cck 1104 37 autoregulates autoregulate NNS cord-267475-6f4h3cck 1104 38 splicing splicing NN cord-267475-6f4h3cck 1104 39 of of IN cord-267475-6f4h3cck 1104 40 its -PRON- PRP$ cord-267475-6f4h3cck 1104 41 transcript transcript NN cord-267475-6f4h3cck 1104 42 Identification identification NN cord-267475-6f4h3cck 1104 43 of of IN cord-267475-6f4h3cck 1104 44 a a DT cord-267475-6f4h3cck 1104 45 new new JJ cord-267475-6f4h3cck 1104 46 form form NN cord-267475-6f4h3cck 1104 47 of of IN cord-267475-6f4h3cck 1104 48 AQP4 AQP4 NNP cord-267475-6f4h3cck 1104 49 mRNA mRNA NNP cord-267475-6f4h3cck 1104 50 that that WDT cord-267475-6f4h3cck 1104 51 is be VBZ cord-267475-6f4h3cck 1104 52 developmentally developmentally RB cord-267475-6f4h3cck 1104 53 expressed express VBN cord-267475-6f4h3cck 1104 54 in in IN cord-267475-6f4h3cck 1104 55 mouse mouse NN cord-267475-6f4h3cck 1104 56 brain brain NN cord-267475-6f4h3cck 1104 57 Identification identification NN cord-267475-6f4h3cck 1104 58 of of IN cord-267475-6f4h3cck 1104 59 a a DT cord-267475-6f4h3cck 1104 60 noncanonical noncanonical JJ cord-267475-6f4h3cck 1104 61 signal signal NN cord-267475-6f4h3cck 1104 62 for for IN cord-267475-6f4h3cck 1104 63 transcription transcription NN cord-267475-6f4h3cck 1104 64 of of IN cord-267475-6f4h3cck 1104 65 a a DT cord-267475-6f4h3cck 1104 66 novel novel JJ cord-267475-6f4h3cck 1104 67 subgenomic subgenomic NNP cord-267475-6f4h3cck 1104 68 mRNA mRNA NNP cord-267475-6f4h3cck 1104 69 of of IN cord-267475-6f4h3cck 1104 70 mouse mouse NNP cord-267475-6f4h3cck 1104 71 hepatitis hepatitis NNP cord-267475-6f4h3cck 1104 72 virus virus NN cord-267475-6f4h3cck 1104 73 : : : cord-267475-6f4h3cck 1105 1 implication implication NN cord-267475-6f4h3cck 1105 2 for for IN cord-267475-6f4h3cck 1105 3 the the DT cord-267475-6f4h3cck 1105 4 mechanism mechanism NN cord-267475-6f4h3cck 1105 5 of of IN cord-267475-6f4h3cck 1105 6 coronavirus coronavirus NN cord-267475-6f4h3cck 1105 7 RNA RNA NNP cord-267475-6f4h3cck 1105 8 transcription transcription NN cord-267475-6f4h3cck 1105 9 Novel Novel NNP cord-267475-6f4h3cck 1105 10 short short JJ cord-267475-6f4h3cck 1105 11 transcripts transcript NNS cord-267475-6f4h3cck 1105 12 of of IN cord-267475-6f4h3cck 1105 13 hepatitis hepatitis NNP cord-267475-6f4h3cck 1105 14 B B NNP cord-267475-6f4h3cck 1105 15 virus virus NN cord-267475-6f4h3cck 1105 16 X x NN cord-267475-6f4h3cck 1105 17 gene gene NN cord-267475-6f4h3cck 1105 18 derived derive VBN cord-267475-6f4h3cck 1105 19 from from IN cord-267475-6f4h3cck 1105 20 intragenic intragenic JJ cord-267475-6f4h3cck 1105 21 promoter promoter NN cord-267475-6f4h3cck 1105 22 Splicing Splicing NNP cord-267475-6f4h3cck 1105 23 in in IN cord-267475-6f4h3cck 1105 24 adenovirus adenovirus NN cord-267475-6f4h3cck 1105 25 and and CC cord-267475-6f4h3cck 1105 26 other other JJ cord-267475-6f4h3cck 1105 27 animal animal NN cord-267475-6f4h3cck 1105 28 viruses virus NNS cord-267475-6f4h3cck 1105 29 Tissue tissue IN cord-267475-6f4h3cck 1105 30 specific specific JJ cord-267475-6f4h3cck 1105 31 expression expression NN cord-267475-6f4h3cck 1105 32 of of IN cord-267475-6f4h3cck 1105 33 the the DT cord-267475-6f4h3cck 1105 34 retinoic retinoic JJ cord-267475-6f4h3cck 1105 35 acid acid NN cord-267475-6f4h3cck 1105 36 receptor receptor NN cord-267475-6f4h3cck 1105 37 - - HYPH cord-267475-6f4h3cck 1105 38 b2 b2 NN cord-267475-6f4h3cck 1105 39 : : : cord-267475-6f4h3cck 1105 40 regulation regulation NN cord-267475-6f4h3cck 1105 41 by by IN cord-267475-6f4h3cck 1105 42 short short JJ cord-267475-6f4h3cck 1105 43 open open JJ cord-267475-6f4h3cck 1105 44 reading reading NN cord-267475-6f4h3cck 1105 45 frames frame NNS cord-267475-6f4h3cck 1105 46 in in IN cord-267475-6f4h3cck 1105 47 the the DT cord-267475-6f4h3cck 1105 48 5 5 CD cord-267475-6f4h3cck 1105 49 0 0 CD cord-267475-6f4h3cck 1105 50 -noncoding -noncoding NN cord-267475-6f4h3cck 1105 51 region region NN cord-267475-6f4h3cck 1105 52 Analysis analysis NN cord-267475-6f4h3cck 1105 53 of of IN cord-267475-6f4h3cck 1105 54 the the DT cord-267475-6f4h3cck 1105 55 CC CC NNP cord-267475-6f4h3cck 1105 56 chemokine chemokine NN cord-267475-6f4h3cck 1105 57 receptor receptor NN cord-267475-6f4h3cck 1105 58 3 3 CD cord-267475-6f4h3cck 1105 59 gene gene NN cord-267475-6f4h3cck 1105 60 reveals reveal VBZ cord-267475-6f4h3cck 1105 61 a a DT cord-267475-6f4h3cck 1105 62 complex complex JJ cord-267475-6f4h3cck 1105 63 5 5 CD cord-267475-6f4h3cck 1105 64 0 0 CD cord-267475-6f4h3cck 1105 65 exon exon NN cord-267475-6f4h3cck 1105 66 organization organization NN cord-267475-6f4h3cck 1105 67 , , , cord-267475-6f4h3cck 1105 68 a a DT cord-267475-6f4h3cck 1105 69 functional functional JJ cord-267475-6f4h3cck 1105 70 role role NN cord-267475-6f4h3cck 1105 71 for for IN cord-267475-6f4h3cck 1105 72 untranslated untranslated JJ cord-267475-6f4h3cck 1105 73 exon exon NN cord-267475-6f4h3cck 1105 74 1 1 CD cord-267475-6f4h3cck 1105 75 , , , cord-267475-6f4h3cck 1105 76 and and CC cord-267475-6f4h3cck 1105 77 a a DT cord-267475-6f4h3cck 1105 78 broadly broadly RB cord-267475-6f4h3cck 1105 79 active active JJ cord-267475-6f4h3cck 1105 80 promoter promoter NN cord-267475-6f4h3cck 1105 81 with with IN cord-267475-6f4h3cck 1105 82 eosinophil eosinophil JJ cord-267475-6f4h3cck 1105 83 - - HYPH cord-267475-6f4h3cck 1105 84 selective selective JJ cord-267475-6f4h3cck 1105 85 elements element NNS cord-267475-6f4h3cck 1106 1 Complete complete JJ cord-267475-6f4h3cck 1106 2 testicular testicular JJ cord-267475-6f4h3cck 1106 3 feminization feminization NN cord-267475-6f4h3cck 1106 4 caused cause VBN cord-267475-6f4h3cck 1106 5 by by IN cord-267475-6f4h3cck 1106 6 an an DT cord-267475-6f4h3cck 1106 7 amino amino NN cord-267475-6f4h3cck 1106 8 - - HYPH cord-267475-6f4h3cck 1106 9 terminal terminal NN cord-267475-6f4h3cck 1106 10 truncation truncation NN cord-267475-6f4h3cck 1106 11 of of IN cord-267475-6f4h3cck 1106 12 the the DT cord-267475-6f4h3cck 1106 13 androgen androgen NN cord-267475-6f4h3cck 1106 14 receptor receptor NN cord-267475-6f4h3cck 1106 15 with with IN cord-267475-6f4h3cck 1106 16 downstream downstream JJ cord-267475-6f4h3cck 1106 17 initiation initiation NN cord-267475-6f4h3cck 1106 18 C C NNP cord-267475-6f4h3cck 1106 19 / / SYM cord-267475-6f4h3cck 1106 20 T t NN cord-267475-6f4h3cck 1106 21 polymorphism polymorphism NN cord-267475-6f4h3cck 1106 22 in in IN cord-267475-6f4h3cck 1106 23 the the DT cord-267475-6f4h3cck 1106 24 5 5 CD cord-267475-6f4h3cck 1106 25 0 0 CD cord-267475-6f4h3cck 1106 26 untranslated untranslated JJ cord-267475-6f4h3cck 1106 27 region region NN cord-267475-6f4h3cck 1106 28 of of IN cord-267475-6f4h3cck 1106 29 the the DT cord-267475-6f4h3cck 1106 30 apolipoprotein(a apolipoprotein(a NNP cord-267475-6f4h3cck 1106 31 ) ) -RRB- cord-267475-6f4h3cck 1106 32 gene gene NN cord-267475-6f4h3cck 1106 33 introduces introduce VBZ cord-267475-6f4h3cck 1106 34 an an DT cord-267475-6f4h3cck 1106 35 upstream upstream JJ cord-267475-6f4h3cck 1106 36 AUG AUG NNP cord-267475-6f4h3cck 1106 37 and and CC cord-267475-6f4h3cck 1106 38 reduces reduce VBZ cord-267475-6f4h3cck 1106 39 in in IN cord-267475-6f4h3cck 1106 40 vitro vitro FW cord-267475-6f4h3cck 1106 41 translation translation NN cord-267475-6f4h3cck 1106 42 Research Research NNP cord-267475-6f4h3cck 1106 43 in in IN cord-267475-6f4h3cck 1106 44 my -PRON- PRP$ cord-267475-6f4h3cck 1106 45 laboratory laboratory NN cord-267475-6f4h3cck 1106 46 is be VBZ cord-267475-6f4h3cck 1106 47 supported support VBN cord-267475-6f4h3cck 1106 48 by by IN cord-267475-6f4h3cck 1106 49 grant grant NN cord-267475-6f4h3cck 1106 50 GM33915 GM33915 NNP cord-267475-6f4h3cck 1106 51 from from IN cord-267475-6f4h3cck 1106 52 the the DT cord-267475-6f4h3cck 1106 53 National National NNP cord-267475-6f4h3cck 1106 54 Institutes Institutes NNPS cord-267475-6f4h3cck 1106 55 of of IN cord-267475-6f4h3cck 1106 56 Health Health NNP cord-267475-6f4h3cck 1106 57 . . .