id	sid	tid	token	lemma	pos
cord-277355-si3g5dih	1	1	key	key	JJ
cord-277355-si3g5dih	1	2	:	:	:
cord-277355-si3g5dih	1	3	cord-277355-si3g5dih	cord-277355-si3g5dih	NNP
cord-277355-si3g5dih	1	4	authors	author	NNS
cord-277355-si3g5dih	1	5	:	:	:
cord-277355-si3g5dih	2	1	He	-PRON-	PRP
cord-277355-si3g5dih	2	2	,	,	,
cord-277355-si3g5dih	2	3	Yu	Yu	NNP
cord-277355-si3g5dih	2	4	;	;	:
cord-277355-si3g5dih	2	5	Wang	Wang	NNP
cord-277355-si3g5dih	2	6	,	,	,
cord-277355-si3g5dih	2	7	Mingshu	Mingshu	NNP
cord-277355-si3g5dih	2	8	;	;	:
cord-277355-si3g5dih	2	9	Chen	Chen	NNP
cord-277355-si3g5dih	2	10	,	,	,
cord-277355-si3g5dih	2	11	Shun	Shun	NNP
cord-277355-si3g5dih	2	12	;	;	:
cord-277355-si3g5dih	2	13	Cheng	Cheng	NNP
cord-277355-si3g5dih	2	14	,	,	,
cord-277355-si3g5dih	2	15	Anchun	Anchun	NNP
cord-277355-si3g5dih	2	16	title	title	NN
cord-277355-si3g5dih	2	17	:	:	:
cord-277355-si3g5dih	2	18	The	the	DT
cord-277355-si3g5dih	2	19	role	role	NN
cord-277355-si3g5dih	2	20	of	of	IN
cord-277355-si3g5dih	2	21	capsid	capsid	NN
cord-277355-si3g5dih	2	22	in	in	IN
cord-277355-si3g5dih	2	23	the	the	DT
cord-277355-si3g5dih	2	24	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	2	25	life	life	NN
cord-277355-si3g5dih	2	26	cycle	cycle	NN
cord-277355-si3g5dih	2	27	and	and	CC
cord-277355-si3g5dih	2	28	perspectives	perspective	NNS
cord-277355-si3g5dih	2	29	for	for	IN
cord-277355-si3g5dih	2	30	vaccine	vaccine	NN
cord-277355-si3g5dih	2	31	development	development	NN
cord-277355-si3g5dih	2	32	date	date	NN
cord-277355-si3g5dih	2	33	:	:	:
cord-277355-si3g5dih	2	34	2020	2020	CD
cord-277355-si3g5dih	2	35	-	-	HYPH
cord-277355-si3g5dih	2	36	09	09	CD
cord-277355-si3g5dih	2	37	-	-	SYM
cord-277355-si3g5dih	2	38	17	17	CD
cord-277355-si3g5dih	2	39	journal	journal	NN
cord-277355-si3g5dih	2	40	:	:	:
cord-277355-si3g5dih	2	41	Vaccine	vaccine	NN
cord-277355-si3g5dih	2	42	DOI	DOI	NNP
cord-277355-si3g5dih	2	43	:	:	:
cord-277355-si3g5dih	2	44	10.1016	10.1016	CD
cord-277355-si3g5dih	2	45	/	/	SYM
cord-277355-si3g5dih	2	46	j.vaccine.2020.08.053	j.vaccine.2020.08.053	UH
cord-277355-si3g5dih	2	47	sha	sha	NNP
cord-277355-si3g5dih	2	48	:	:	:
cord-277355-si3g5dih	3	1	45b7fb1a28326ebd8f42df480e50783fe5b61cf7	45b7fb1a28326ebd8f42df480e50783fe5b61cf7	LS
cord-277355-si3g5dih	3	2	doc_id	doc_id	CD
cord-277355-si3g5dih	3	3	:	:	:
cord-277355-si3g5dih	3	4	277355	277355	CD
cord-277355-si3g5dih	3	5	cord_uid	cord_uid	NNS
cord-277355-si3g5dih	3	6	:	:	:
cord-277355-si3g5dih	4	1	si3g5dih	si3g5dih	NNP
cord-277355-si3g5dih	5	1	The	the	DT
cord-277355-si3g5dih	5	2	arthropod	arthropod	NN
cord-277355-si3g5dih	5	3	-	-	HYPH
cord-277355-si3g5dih	5	4	borne	bear	VBN
cord-277355-si3g5dih	5	5	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	5	6	cause	cause	VBP
cord-277355-si3g5dih	5	7	a	a	DT
cord-277355-si3g5dih	5	8	series	series	NN
cord-277355-si3g5dih	5	9	of	of	IN
cord-277355-si3g5dih	5	10	diseases	disease	NNS
cord-277355-si3g5dih	5	11	in	in	IN
cord-277355-si3g5dih	5	12	humans	human	NNS
cord-277355-si3g5dih	5	13	and	and	CC
cord-277355-si3g5dih	5	14	pose	pose	VBP
cord-277355-si3g5dih	5	15	a	a	DT
cord-277355-si3g5dih	5	16	significant	significant	JJ
cord-277355-si3g5dih	5	17	threat	threat	NN
cord-277355-si3g5dih	5	18	to	to	IN
cord-277355-si3g5dih	5	19	global	global	JJ
cord-277355-si3g5dih	5	20	public	public	JJ
cord-277355-si3g5dih	5	21	health	health	NN
cord-277355-si3g5dih	5	22	.	.	.
cord-277355-si3g5dih	6	1	In	in	IN
cord-277355-si3g5dih	6	2	this	this	DT
cord-277355-si3g5dih	6	3	review	review	NN
cord-277355-si3g5dih	6	4	,	,	,
cord-277355-si3g5dih	6	5	we	-PRON-	PRP
cord-277355-si3g5dih	6	6	aimed	aim	VBD
cord-277355-si3g5dih	6	7	to	to	TO
cord-277355-si3g5dih	6	8	summarize	summarize	VB
cord-277355-si3g5dih	6	9	the	the	DT
cord-277355-si3g5dih	6	10	structure	structure	NN
cord-277355-si3g5dih	6	11	of	of	IN
cord-277355-si3g5dih	6	12	the	the	DT
cord-277355-si3g5dih	6	13	capsid	capsid	NN
cord-277355-si3g5dih	6	14	protein	protein	NN
cord-277355-si3g5dih	6	15	(	(	-LRB-
cord-277355-si3g5dih	6	16	CP	CP	NNP
cord-277355-si3g5dih	6	17	)	)	-RRB-
cord-277355-si3g5dih	6	18	,	,	,
cord-277355-si3g5dih	6	19	its	-PRON-	PRP$
cord-277355-si3g5dih	6	20	relevant	relevant	JJ
cord-277355-si3g5dih	6	21	multiple	multiple	JJ
cord-277355-si3g5dih	6	22	functions	function	NNS
cord-277355-si3g5dih	6	23	in	in	IN
cord-277355-si3g5dih	6	24	the	the	DT
cord-277355-si3g5dih	6	25	viral	viral	JJ
cord-277355-si3g5dih	6	26	life	life	NN
cord-277355-si3g5dih	6	27	cycle	cycle	NN
cord-277355-si3g5dih	6	28	and	and	CC
cord-277355-si3g5dih	6	29	innovative	innovative	JJ
cord-277355-si3g5dih	6	30	vaccines	vaccine	NNS
cord-277355-si3g5dih	6	31	targeting	target	VBG
cord-277355-si3g5dih	6	32	CP	cp	NN
cord-277355-si3g5dih	6	33	.	.	.
cord-277355-si3g5dih	7	1	The	the	DT
cord-277355-si3g5dih	7	2	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	7	3	CP	cp	NN
cord-277355-si3g5dih	7	4	is	be	VBZ
cord-277355-si3g5dih	7	5	the	the	DT
cord-277355-si3g5dih	7	6	smallest	small	JJS
cord-277355-si3g5dih	7	7	structural	structural	JJ
cord-277355-si3g5dih	7	8	protein	protein	NN
cord-277355-si3g5dih	7	9	and	and	CC
cord-277355-si3g5dih	7	10	forms	form	VBZ
cord-277355-si3g5dih	7	11	a	a	DT
cord-277355-si3g5dih	7	12	homodimer	homodimer	JJ
cord-277355-si3g5dih	7	13	by	by	IN
cord-277355-si3g5dih	7	14	antiparallel	antiparallel	JJ
cord-277355-si3g5dih	7	15	α	α	NN
cord-277355-si3g5dih	7	16	-	-	HYPH
cord-277355-si3g5dih	7	17	helixes	helix	NNS
cord-277355-si3g5dih	7	18	.	.	.
cord-277355-si3g5dih	8	1	Its	-PRON-	PRP$
cord-277355-si3g5dih	8	2	primary	primary	JJ
cord-277355-si3g5dih	8	3	function	function	NN
cord-277355-si3g5dih	8	4	is	be	VBZ
cord-277355-si3g5dih	8	5	to	to	TO
cord-277355-si3g5dih	8	6	package	package	VB
cord-277355-si3g5dih	8	7	the	the	DT
cord-277355-si3g5dih	8	8	genomic	genomic	JJ
cord-277355-si3g5dih	8	9	RNA	rna	NN
cord-277355-si3g5dih	8	10	;	;	:
cord-277355-si3g5dih	8	11	however	however	RB
cord-277355-si3g5dih	8	12	,	,	,
cord-277355-si3g5dih	8	13	both	both	DT
cord-277355-si3g5dih	8	14	steps	step	NNS
cord-277355-si3g5dih	8	15	of	of	IN
cord-277355-si3g5dih	8	16	assembly	assembly	NN
cord-277355-si3g5dih	8	17	and	and	CC
cord-277355-si3g5dih	8	18	dissociation	dissociation	NN
cord-277355-si3g5dih	8	19	of	of	IN
cord-277355-si3g5dih	8	20	nucleocapsid	nucleocapsid	NNP
cord-277355-si3g5dih	8	21	complexes	complexes	NNP
cord-277355-si3g5dih	8	22	(	(	-LRB-
cord-277355-si3g5dih	8	23	NCs	NCs	NNP
cord-277355-si3g5dih	8	24	)	)	-RRB-
cord-277355-si3g5dih	8	25	have	have	VBP
cord-277355-si3g5dih	8	26	been	be	VBN
cord-277355-si3g5dih	8	27	obscure	obscure	JJ
cord-277355-si3g5dih	8	28	until	until	IN
cord-277355-si3g5dih	8	29	now	now	RB
cord-277355-si3g5dih	8	30	;	;	:
cord-277355-si3g5dih	8	31	in	in	IN
cord-277355-si3g5dih	8	32	fact	fact	NN
cord-277355-si3g5dih	8	33	,	,	,
cord-277355-si3g5dih	8	34	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	8	35	budding	budding	NN
cord-277355-si3g5dih	8	36	is	be	VBZ
cord-277355-si3g5dih	8	37	NC	NC	NNP
cord-277355-si3g5dih	8	38	-	-	HYPH
cord-277355-si3g5dih	8	39	free	free	JJ
cord-277355-si3g5dih	8	40	,	,	,
cord-277355-si3g5dih	8	41	demonstrated	demonstrate	VBN
cord-277355-si3g5dih	8	42	by	by	IN
cord-277355-si3g5dih	8	43	the	the	DT
cord-277355-si3g5dih	8	44	subviral	subviral	JJ
cord-277355-si3g5dih	8	45	particles	particle	NNS
cord-277355-si3g5dih	8	46	that	that	WDT
cord-277355-si3g5dih	8	47	generally	generally	RB
cord-277355-si3g5dih	8	48	exist	exist	VBP
cord-277355-si3g5dih	8	49	in	in	IN
cord-277355-si3g5dih	8	50	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	8	51	infection	infection	NN
cord-277355-si3g5dih	8	52	.	.	.
cord-277355-si3g5dih	9	1	In	in	IN
cord-277355-si3g5dih	9	2	infected	infected	JJ
cord-277355-si3g5dih	9	3	cells	cell	NNS
cord-277355-si3g5dih	9	4	,	,	,
cord-277355-si3g5dih	9	5	CPs	cp	NNS
cord-277355-si3g5dih	9	6	associate	associate	VBP
cord-277355-si3g5dih	9	7	with	with	IN
cord-277355-si3g5dih	9	8	lipid	lipid	NN
cord-277355-si3g5dih	9	9	droplets	droplet	NNS
cord-277355-si3g5dih	9	10	,	,	,
cord-277355-si3g5dih	9	11	which	which	WDT
cord-277355-si3g5dih	9	12	possibly	possibly	RB
cord-277355-si3g5dih	9	13	store	store	VBP
cord-277355-si3g5dih	9	14	CPs	cp	NNS
cord-277355-si3g5dih	9	15	prior	prior	RB
cord-277355-si3g5dih	9	16	to	to	IN
cord-277355-si3g5dih	9	17	packaging	packaging	NN
cord-277355-si3g5dih	9	18	.	.	.
cord-277355-si3g5dih	10	1	However	however	RB
cord-277355-si3g5dih	10	2	,	,	,
cord-277355-si3g5dih	10	3	the	the	DT
cord-277355-si3g5dih	10	4	function	function	NN
cord-277355-si3g5dih	10	5	of	of	IN
cord-277355-si3g5dih	10	6	nuclear	nuclear	JJ
cord-277355-si3g5dih	10	7	localization	localization	NN
cord-277355-si3g5dih	10	8	of	of	IN
cord-277355-si3g5dih	10	9	CPs	cp	NNS
cord-277355-si3g5dih	10	10	remains	remain	VBZ
cord-277355-si3g5dih	10	11	unknown	unknown	JJ
cord-277355-si3g5dih	10	12	.	.	.
cord-277355-si3g5dih	11	1	Moreover	moreover	RB
cord-277355-si3g5dih	11	2	,	,	,
cord-277355-si3g5dih	11	3	introducing	introduce	VBG
cord-277355-si3g5dih	11	4	deletions	deletion	NNS
cord-277355-si3g5dih	11	5	into	into	IN
cord-277355-si3g5dih	11	6	CPs	cp	NNS
cord-277355-si3g5dih	11	7	can	can	MD
cord-277355-si3g5dih	11	8	be	be	VB
cord-277355-si3g5dih	11	9	used	use	VBN
cord-277355-si3g5dih	11	10	to	to	TO
cord-277355-si3g5dih	11	11	rationally	rationally	RB
cord-277355-si3g5dih	11	12	design	design	VB
cord-277355-si3g5dih	11	13	safe	safe	JJ
cord-277355-si3g5dih	11	14	and	and	CC
cord-277355-si3g5dih	11	15	effective	effective	JJ
cord-277355-si3g5dih	11	16	live	live	RB
cord-277355-si3g5dih	11	17	-	-	HYPH
cord-277355-si3g5dih	11	18	attenuated	attenuate	VBN
cord-277355-si3g5dih	11	19	vaccines	vaccine	NNS
cord-277355-si3g5dih	11	20	or	or	CC
cord-277355-si3g5dih	11	21	noninfectious	noninfectious	JJ
cord-277355-si3g5dih	11	22	replicon	replicon	NN
cord-277355-si3g5dih	11	23	vaccines	vaccine	NNS
cord-277355-si3g5dih	11	24	and	and	CC
cord-277355-si3g5dih	11	25	single	single	JJ
cord-277355-si3g5dih	11	26	-	-	HYPH
cord-277355-si3g5dih	11	27	round	round	NN
cord-277355-si3g5dih	11	28	infectious	infectious	JJ
cord-277355-si3g5dih	11	29	particles	particle	NNS
cord-277355-si3g5dih	11	30	,	,	,
cord-277355-si3g5dih	11	31	the	the	DT
cord-277355-si3g5dih	11	32	latter	latter	JJ
cord-277355-si3g5dih	11	33	two	two	CD
cord-277355-si3g5dih	11	34	representing	represent	VBG
cord-277355-si3g5dih	11	35	promising	promising	JJ
cord-277355-si3g5dih	11	36	approaches	approach	NNS
cord-277355-si3g5dih	11	37	for	for	IN
cord-277355-si3g5dih	11	38	innovative	innovative	JJ
cord-277355-si3g5dih	11	39	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	11	40	vaccine	vaccine	NN
cord-277355-si3g5dih	11	41	development	development	NN
cord-277355-si3g5dih	11	42	.	.	.
cord-277355-si3g5dih	12	1	The	the	DT
cord-277355-si3g5dih	12	2	emergence	emergence	NN
cord-277355-si3g5dih	12	3	or	or	CC
cord-277355-si3g5dih	12	4	reemergence	reemergence	NN
cord-277355-si3g5dih	12	5	of	of	IN
cord-277355-si3g5dih	12	6	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	12	7	,	,	,
cord-277355-si3g5dih	12	8	including	include	VBG
cord-277355-si3g5dih	12	9	dengue	dengue	NN
cord-277355-si3g5dih	12	10	virus	virus	NN
cord-277355-si3g5dih	12	11	(	(	-LRB-
cord-277355-si3g5dih	12	12	DENV	DENV	NNP
cord-277355-si3g5dih	12	13	)	)	-RRB-
cord-277355-si3g5dih	12	14	,	,	,
cord-277355-si3g5dih	12	15	Zika	Zika	NNP
cord-277355-si3g5dih	12	16	virus	virus	NN
cord-277355-si3g5dih	12	17	(	(	-LRB-
cord-277355-si3g5dih	12	18	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	12	19	)	)	-RRB-
cord-277355-si3g5dih	12	20	,	,	,
cord-277355-si3g5dih	12	21	yellow	yellow	JJ
cord-277355-si3g5dih	12	22	fever	fever	NN
cord-277355-si3g5dih	12	23	virus	virus	NN
cord-277355-si3g5dih	12	24	(	(	-LRB-
cord-277355-si3g5dih	12	25	YFV	YFV	NNP
cord-277355-si3g5dih	12	26	)	)	-RRB-
cord-277355-si3g5dih	12	27	,	,	,
cord-277355-si3g5dih	12	28	Japanese	japanese	JJ
cord-277355-si3g5dih	12	29	encephalitis	encephalitis	RB
cord-277355-si3g5dih	12	30	virus	virus	NN
cord-277355-si3g5dih	12	31	(	(	-LRB-
cord-277355-si3g5dih	12	32	JEV	JEV	NNP
cord-277355-si3g5dih	12	33	)	)	-RRB-
cord-277355-si3g5dih	12	34	,	,	,
cord-277355-si3g5dih	12	35	West	West	NNP
cord-277355-si3g5dih	12	36	Nile	Nile	NNP
cord-277355-si3g5dih	12	37	virus	virus	NN
cord-277355-si3g5dih	12	38	(	(	-LRB-
cord-277355-si3g5dih	12	39	WNV	WNV	NNP
cord-277355-si3g5dih	12	40	)	)	-RRB-
cord-277355-si3g5dih	12	41	,	,	,
cord-277355-si3g5dih	12	42	and	and	CC
cord-277355-si3g5dih	12	43	tickborne	tickborne	NNP
cord-277355-si3g5dih	12	44	encephalitis	encephalitis	NN
cord-277355-si3g5dih	12	45	virus	virus	NN
cord-277355-si3g5dih	12	46	(	(	-LRB-
cord-277355-si3g5dih	12	47	TBEV	TBEV	NNP
cord-277355-si3g5dih	12	48	)	)	-RRB-
cord-277355-si3g5dih	12	49	,	,	,
cord-277355-si3g5dih	12	50	has	have	VBZ
cord-277355-si3g5dih	12	51	posed	pose	VBN
cord-277355-si3g5dih	12	52	an	an	DT
cord-277355-si3g5dih	12	53	enormous	enormous	JJ
cord-277355-si3g5dih	12	54	threat	threat	NN
cord-277355-si3g5dih	12	55	to	to	IN
cord-277355-si3g5dih	12	56	global	global	JJ
cord-277355-si3g5dih	12	57	public	public	JJ
cord-277355-si3g5dih	12	58	health	health	NN
cord-277355-si3g5dih	12	59	in	in	IN
cord-277355-si3g5dih	12	60	recent	recent	JJ
cord-277355-si3g5dih	12	61	decades	decade	NNS
cord-277355-si3g5dih	12	62	.	.	.
cord-277355-si3g5dih	13	1	Most	Most	JJS
cord-277355-si3g5dih	13	2	of	of	IN
cord-277355-si3g5dih	13	3	these	these	DT
cord-277355-si3g5dih	13	4	viruses	virus	NNS
cord-277355-si3g5dih	13	5	are	be	VBP
cord-277355-si3g5dih	13	6	arthropod	arthropod	NN
cord-277355-si3g5dih	13	7	-	-	HYPH
cord-277355-si3g5dih	13	8	borne	bear	VBN
cord-277355-si3g5dih	13	9	viruses	virus	NNS
cord-277355-si3g5dih	13	10	(	(	-LRB-
cord-277355-si3g5dih	13	11	i.e.	i.e.	FW
cord-277355-si3g5dih	13	12	,	,	,
cord-277355-si3g5dih	13	13	arboviruses	arboviruses	NNP
cord-277355-si3g5dih	13	14	)	)	-RRB-
cord-277355-si3g5dih	13	15	that	that	WDT
cord-277355-si3g5dih	13	16	are	be	VBP
cord-277355-si3g5dih	13	17	transmitted	transmit	VBN
cord-277355-si3g5dih	13	18	to	to	IN
cord-277355-si3g5dih	13	19	vertebrate	vertebrate	JJ
cord-277355-si3g5dih	13	20	hosts	host	NNS
cord-277355-si3g5dih	13	21	through	through	IN
cord-277355-si3g5dih	13	22	the	the	DT
cord-277355-si3g5dih	13	23	bites	bite	NNS
cord-277355-si3g5dih	13	24	of	of	IN
cord-277355-si3g5dih	13	25	infected	infected	JJ
cord-277355-si3g5dih	13	26	mosquitoes	mosquito	NNS
cord-277355-si3g5dih	13	27	or	or	CC
cord-277355-si3g5dih	13	28	ticks	tick	NNS
cord-277355-si3g5dih	13	29	,	,	,
cord-277355-si3g5dih	13	30	causing	cause	VBG
cord-277355-si3g5dih	13	31	diseases	disease	NNS
cord-277355-si3g5dih	13	32	in	in	IN
cord-277355-si3g5dih	13	33	animals	animal	NNS
cord-277355-si3g5dih	13	34	and	and	CC
cord-277355-si3g5dih	13	35	humans	human	NNS
cord-277355-si3g5dih	13	36	.	.	.
cord-277355-si3g5dih	14	1	Among	among	IN
cord-277355-si3g5dih	14	2	them	-PRON-	PRP
cord-277355-si3g5dih	14	3	,	,	,
cord-277355-si3g5dih	14	4	DENV	DENV	NNP
cord-277355-si3g5dih	14	5	is	be	VBZ
cord-277355-si3g5dih	14	6	the	the	DT
cord-277355-si3g5dih	14	7	most	most	RBS
cord-277355-si3g5dih	14	8	important	important	JJ
cord-277355-si3g5dih	14	9	human	human	JJ
cord-277355-si3g5dih	14	10	pathogen	pathogen	NN
cord-277355-si3g5dih	14	11	,	,	,
cord-277355-si3g5dih	14	12	with	with	IN
cord-277355-si3g5dih	14	13	approximately	approximately	RB
cord-277355-si3g5dih	14	14	390	390	CD
cord-277355-si3g5dih	14	15	million	million	CD
cord-277355-si3g5dih	14	16	infections	infection	NNS
cord-277355-si3g5dih	14	17	every	every	DT
cord-277355-si3g5dih	14	18	year	year	NN
cord-277355-si3g5dih	14	19	[	[	-LRB-
cord-277355-si3g5dih	14	20	1	1	CD
cord-277355-si3g5dih	14	21	]	]	-RRB-
cord-277355-si3g5dih	14	22	.	.	.
cord-277355-si3g5dih	15	1	Flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	15	2	are	be	VBP
cord-277355-si3g5dih	15	3	a	a	DT
cord-277355-si3g5dih	15	4	group	group	NN
cord-277355-si3g5dih	15	5	of	of	IN
cord-277355-si3g5dih	15	6	enveloped	envelop	VBN
cord-277355-si3g5dih	15	7	positive	positive	JJ
cord-277355-si3g5dih	15	8	-	-	HYPH
cord-277355-si3g5dih	15	9	sense	sense	NN
cord-277355-si3g5dih	15	10	RNA	RNA	NNP
cord-277355-si3g5dih	15	11	viruses	virus	NNS
cord-277355-si3g5dih	15	12	.	.	.
cord-277355-si3g5dih	16	1	The	the	DT
cord-277355-si3g5dih	16	2	viral	viral	JJ
cord-277355-si3g5dih	16	3	shell	shell	NN
cord-277355-si3g5dih	16	4	is	be	VBZ
cord-277355-si3g5dih	16	5	formed	form	VBN
cord-277355-si3g5dih	16	6	by	by	IN
cord-277355-si3g5dih	16	7	180	180	CD
cord-277355-si3g5dih	16	8	copies	copy	NNS
cord-277355-si3g5dih	16	9	of	of	IN
cord-277355-si3g5dih	16	10	glycosylated	glycosylated	JJ
cord-277355-si3g5dih	16	11	E	e	NN
cord-277355-si3g5dih	16	12	and	and	CC
cord-277355-si3g5dih	16	13	M	M	NNP
cord-277355-si3g5dih	16	14	proteins	protein	NNS
cord-277355-si3g5dih	16	15	,	,	,
cord-277355-si3g5dih	16	16	which	which	WDT
cord-277355-si3g5dih	16	17	are	be	VBP
cord-277355-si3g5dih	16	18	anchored	anchor	VBN
cord-277355-si3g5dih	16	19	to	to	IN
cord-277355-si3g5dih	16	20	a	a	DT
cord-277355-si3g5dih	16	21	lipid	lipid	NN
cord-277355-si3g5dih	16	22	bilayer	bilayer	NN
cord-277355-si3g5dih	16	23	;	;	:
cord-277355-si3g5dih	16	24	within	within	IN
cord-277355-si3g5dih	16	25	the	the	DT
cord-277355-si3g5dih	16	26	lipid	lipid	NN
cord-277355-si3g5dih	16	27	bilayer	bilayer	NN
cord-277355-si3g5dih	16	28	,	,	,
cord-277355-si3g5dih	16	29	the	the	DT
cord-277355-si3g5dih	16	30	core	core	NN
cord-277355-si3g5dih	16	31	of	of	IN
cord-277355-si3g5dih	16	32	the	the	DT
cord-277355-si3g5dih	16	33	viral	viral	JJ
cord-277355-si3g5dih	16	34	particle	particle	NN
cord-277355-si3g5dih	16	35	is	be	VBZ
cord-277355-si3g5dih	16	36	the	the	DT
cord-277355-si3g5dih	16	37	nucleocapsid	nucleocapsid	NN
cord-277355-si3g5dih	16	38	complex	complex	JJ
cord-277355-si3g5dih	16	39	(	(	-LRB-
cord-277355-si3g5dih	16	40	NC	NC	NNP
cord-277355-si3g5dih	16	41	)	)	-RRB-
cord-277355-si3g5dih	16	42	,	,	,
cord-277355-si3g5dih	16	43	which	which	WDT
cord-277355-si3g5dih	16	44	consists	consist	VBZ
cord-277355-si3g5dih	16	45	of	of	IN
cord-277355-si3g5dih	16	46	capsid	capsid	NN
cord-277355-si3g5dih	16	47	proteins	protein	NNS
cord-277355-si3g5dih	16	48	(	(	-LRB-
cord-277355-si3g5dih	16	49	CPs	cp	NNS
cord-277355-si3g5dih	16	50	)	)	-RRB-
cord-277355-si3g5dih	16	51	and	and	CC
cord-277355-si3g5dih	16	52	viral	viral	JJ
cord-277355-si3g5dih	16	53	genomic	genomic	JJ
cord-277355-si3g5dih	16	54	RNA	RNA	NNP
cord-277355-si3g5dih	16	55	(	(	-LRB-
cord-277355-si3g5dih	16	56	vRNA	vrna	JJ
cord-277355-si3g5dih	16	57	)	)	-RRB-
cord-277355-si3g5dih	17	1	[	[	-LRB-
cord-277355-si3g5dih	17	2	2	2	LS
cord-277355-si3g5dih	17	3	]	]	-RRB-
cord-277355-si3g5dih	17	4	[	[	-LRB-
cord-277355-si3g5dih	17	5	3	3	CD
cord-277355-si3g5dih	17	6	]	]	-RRB-
cord-277355-si3g5dih	17	7	[	[	-LRB-
cord-277355-si3g5dih	17	8	4	4	CD
cord-277355-si3g5dih	17	9	]	]	-RRB-
cord-277355-si3g5dih	17	10	[	[	-LRB-
cord-277355-si3g5dih	17	11	5	5	CD
cord-277355-si3g5dih	17	12	]	]	-RRB-
cord-277355-si3g5dih	17	13	[	[	-LRB-
cord-277355-si3g5dih	17	14	6	6	CD
cord-277355-si3g5dih	17	15	]	]	-RRB-
cord-277355-si3g5dih	17	16	.	.	.
cord-277355-si3g5dih	18	1	The	the	DT
cord-277355-si3g5dih	18	2	viral	viral	JJ
cord-277355-si3g5dih	18	3	genome	genome	NN
cord-277355-si3g5dih	18	4	is	be	VBZ
cord-277355-si3g5dih	18	5	approximately	approximately	RB
cord-277355-si3g5dih	18	6	11,000	11,000	CD
cord-277355-si3g5dih	18	7	nucleotides	nucleotide	NNS
cord-277355-si3g5dih	18	8	in	in	IN
cord-277355-si3g5dih	18	9	length	length	NN
cord-277355-si3g5dih	18	10	and	and	CC
cord-277355-si3g5dih	18	11	contains	contain	VBZ
cord-277355-si3g5dih	18	12	a	a	DT
cord-277355-si3g5dih	18	13	single	single	JJ
cord-277355-si3g5dih	18	14	open	open	JJ
cord-277355-si3g5dih	18	15	reading	reading	NN
cord-277355-si3g5dih	18	16	frame	frame	NN
cord-277355-si3g5dih	18	17	encoding	encode	VBG
cord-277355-si3g5dih	18	18	a	a	DT
cord-277355-si3g5dih	18	19	polyprotein	polyprotein	NN
cord-277355-si3g5dih	18	20	of	of	IN
cord-277355-si3g5dih	18	21	approximately	approximately	RB
cord-277355-si3g5dih	18	22	3400	3400	CD
cord-277355-si3g5dih	18	23	amino	amino	JJ
cord-277355-si3g5dih	18	24	acids	acid	NNS
cord-277355-si3g5dih	18	25	.	.	.
cord-277355-si3g5dih	19	1	After	after	IN
cord-277355-si3g5dih	19	2	cleavage	cleavage	NN
cord-277355-si3g5dih	19	3	by	by	IN
cord-277355-si3g5dih	19	4	the	the	DT
cord-277355-si3g5dih	19	5	viral	viral	JJ
cord-277355-si3g5dih	19	6	NS3	ns3	RB
cord-277355-si3g5dih	19	7	protease	protease	NN
cord-277355-si3g5dih	19	8	(	(	-LRB-
cord-277355-si3g5dih	19	9	with	with	IN
cord-277355-si3g5dih	19	10	cofactor	cofactor	NN
cord-277355-si3g5dih	19	11	NS2B	NS2B	NNP
cord-277355-si3g5dih	19	12	)	)	-RRB-
cord-277355-si3g5dih	19	13	and	and	CC
cord-277355-si3g5dih	19	14	host	host	NN
cord-277355-si3g5dih	19	15	signalase	signalase	NN
cord-277355-si3g5dih	19	16	,	,	,
cord-277355-si3g5dih	19	17	the	the	DT
cord-277355-si3g5dih	19	18	polyprotein	polyprotein	NN
cord-277355-si3g5dih	19	19	generates	generate	VBZ
cord-277355-si3g5dih	19	20	three	three	CD
cord-277355-si3g5dih	19	21	structural	structural	JJ
cord-277355-si3g5dih	19	22	proteins	protein	NNS
cord-277355-si3g5dih	19	23	(	(	-LRB-
cord-277355-si3g5dih	19	24	C	C	NNP
cord-277355-si3g5dih	19	25	,	,	,
cord-277355-si3g5dih	19	26	prM	prm	JJ
cord-277355-si3g5dih	19	27	,	,	,
cord-277355-si3g5dih	19	28	and	and	CC
cord-277355-si3g5dih	19	29	E	E	NNP
cord-277355-si3g5dih	19	30	)	)	-RRB-
cord-277355-si3g5dih	19	31	and	and	CC
cord-277355-si3g5dih	19	32	seven	seven	CD
cord-277355-si3g5dih	19	33	nonstructural	nonstructural	JJ
cord-277355-si3g5dih	19	34	proteins	protein	NNS
cord-277355-si3g5dih	19	35	(	(	-LRB-
cord-277355-si3g5dih	19	36	NS1	ns1	UH
cord-277355-si3g5dih	19	37	,	,	,
cord-277355-si3g5dih	19	38	NS2A/2B	NS2A/2B	NNP
cord-277355-si3g5dih	19	39	,	,	,
cord-277355-si3g5dih	19	40	NS3	ns3	RB
cord-277355-si3g5dih	19	41	,	,	,
cord-277355-si3g5dih	19	42	NS4A/4B	NS4A/4B	NNP
cord-277355-si3g5dih	19	43	,	,	,
cord-277355-si3g5dih	19	44	and	and	CC
cord-277355-si3g5dih	19	45	NS5	ns5	JJ
cord-277355-si3g5dih	19	46	)	)	-RRB-
cord-277355-si3g5dih	19	47	[	[	-LRB-
cord-277355-si3g5dih	19	48	7	7	CD
cord-277355-si3g5dih	19	49	]	]	-RRB-
cord-277355-si3g5dih	19	50	.	.	.
cord-277355-si3g5dih	20	1	Over	over	IN
cord-277355-si3g5dih	20	2	the	the	DT
cord-277355-si3g5dih	20	3	past	past	JJ
cord-277355-si3g5dih	20	4	decades	decade	NNS
cord-277355-si3g5dih	20	5	,	,	,
cord-277355-si3g5dih	20	6	great	great	JJ
cord-277355-si3g5dih	20	7	advances	advance	NNS
cord-277355-si3g5dih	20	8	have	have	VBP
cord-277355-si3g5dih	20	9	been	be	VBN
cord-277355-si3g5dih	20	10	made	make	VBN
cord-277355-si3g5dih	20	11	to	to	TO
cord-277355-si3g5dih	20	12	understand	understand	VB
cord-277355-si3g5dih	20	13	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	20	14	,	,	,
cord-277355-si3g5dih	20	15	but	but	CC
cord-277355-si3g5dih	20	16	the	the	DT
cord-277355-si3g5dih	20	17	CP	cp	NN
cord-277355-si3g5dih	20	18	-	-	HYPH
cord-277355-si3g5dih	20	19	related	relate	VBN
cord-277355-si3g5dih	20	20	processes	process	NNS
cord-277355-si3g5dih	20	21	,	,	,
cord-277355-si3g5dih	20	22	viral	viral	JJ
cord-277355-si3g5dih	20	23	encapsidation	encapsidation	NN
cord-277355-si3g5dih	20	24	and	and	CC
cord-277355-si3g5dih	20	25	uncoating	uncoating	NN
cord-277355-si3g5dih	20	26	are	be	VBP
cord-277355-si3g5dih	20	27	still	still	RB
cord-277355-si3g5dih	20	28	unclear	unclear	JJ
cord-277355-si3g5dih	20	29	.	.	.
cord-277355-si3g5dih	21	1	Although	although	IN
cord-277355-si3g5dih	21	2	vaccines	vaccine	NNS
cord-277355-si3g5dih	21	3	for	for	IN
cord-277355-si3g5dih	21	4	YFV	YFV	NNP
cord-277355-si3g5dih	21	5	,	,	,
cord-277355-si3g5dih	21	6	JEV	JEV	NNP
cord-277355-si3g5dih	21	7	,	,	,
cord-277355-si3g5dih	21	8	and	and	CC
cord-277355-si3g5dih	21	9	TBEV	TBEV	NNP
cord-277355-si3g5dih	21	10	have	have	VBP
cord-277355-si3g5dih	21	11	obtained	obtain	VBN
cord-277355-si3g5dih	21	12	successes	success	NNS
cord-277355-si3g5dih	21	13	and	and	CC
cord-277355-si3g5dih	21	14	progress	progress	NN
cord-277355-si3g5dih	21	15	has	have	VBZ
cord-277355-si3g5dih	21	16	been	be	VBN
cord-277355-si3g5dih	21	17	made	make	VBN
cord-277355-si3g5dih	21	18	in	in	IN
cord-277355-si3g5dih	21	19	DENV	DENV	NNP
cord-277355-si3g5dih	21	20	vaccine	vaccine	NN
cord-277355-si3g5dih	21	21	development	development	NN
cord-277355-si3g5dih	21	22	,	,	,
cord-277355-si3g5dih	21	23	there	there	EX
cord-277355-si3g5dih	21	24	are	be	VBP
cord-277355-si3g5dih	21	25	still	still	RB
cord-277355-si3g5dih	21	26	some	some	DT
cord-277355-si3g5dih	21	27	aspects	aspect	NNS
cord-277355-si3g5dih	21	28	that	that	WDT
cord-277355-si3g5dih	21	29	are	be	VBP
cord-277355-si3g5dih	21	30	less	less	JJR
cord-277355-si3g5dih	21	31	than	than	IN
cord-277355-si3g5dih	21	32	satisfactory	satisfactory	JJ
cord-277355-si3g5dih	21	33	,	,	,
cord-277355-si3g5dih	21	34	and	and	CC
cord-277355-si3g5dih	21	35	there	there	EX
cord-277355-si3g5dih	21	36	are	be	VBP
cord-277355-si3g5dih	21	37	still	still	RB
cord-277355-si3g5dih	21	38	no	no	DT
cord-277355-si3g5dih	21	39	available	available	JJ
cord-277355-si3g5dih	21	40	vaccines	vaccine	NNS
cord-277355-si3g5dih	21	41	for	for	IN
cord-277355-si3g5dih	21	42	WNV	WNV	NNP
cord-277355-si3g5dih	21	43	and	and	CC
cord-277355-si3g5dih	21	44	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	21	45	.	.	.
cord-277355-si3g5dih	22	1	Vaccines	vaccine	NNS
cord-277355-si3g5dih	22	2	play	play	VBP
cord-277355-si3g5dih	22	3	a	a	DT
cord-277355-si3g5dih	22	4	key	key	JJ
cord-277355-si3g5dih	22	5	role	role	NN
cord-277355-si3g5dih	22	6	in	in	IN
cord-277355-si3g5dih	22	7	preventing	prevent	VBG
cord-277355-si3g5dih	22	8	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	22	9	infection	infection	NN
cord-277355-si3g5dih	22	10	and	and	CC
cord-277355-si3g5dih	22	11	controlling	control	VBG
cord-277355-si3g5dih	22	12	viral	viral	JJ
cord-277355-si3g5dih	22	13	spread	spread	NN
cord-277355-si3g5dih	22	14	,	,	,
cord-277355-si3g5dih	22	15	considering	consider	VBG
cord-277355-si3g5dih	22	16	that	that	IN
cord-277355-si3g5dih	22	17	there	there	EX
cord-277355-si3g5dih	22	18	is	be	VBZ
cord-277355-si3g5dih	22	19	no	no	DT
cord-277355-si3g5dih	22	20	specific	specific	JJ
cord-277355-si3g5dih	22	21	treatment	treatment	NN
cord-277355-si3g5dih	22	22	available	available	JJ
cord-277355-si3g5dih	22	23	for	for	IN
cord-277355-si3g5dih	22	24	the	the	DT
cord-277355-si3g5dih	22	25	diseases	disease	NNS
cord-277355-si3g5dih	22	26	caused	cause	VBN
cord-277355-si3g5dih	22	27	by	by	IN
cord-277355-si3g5dih	22	28	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	22	29	;	;	:
cord-277355-si3g5dih	22	30	thus	thus	RB
cord-277355-si3g5dih	22	31	,	,	,
cord-277355-si3g5dih	22	32	vaccine	vaccine	NN
cord-277355-si3g5dih	22	33	development	development	NN
cord-277355-si3g5dih	22	34	is	be	VBZ
cord-277355-si3g5dih	22	35	a	a	DT
cord-277355-si3g5dih	22	36	consistently	consistently	RB
cord-277355-si3g5dih	22	37	important	important	JJ
cord-277355-si3g5dih	22	38	issue	issue	NN
cord-277355-si3g5dih	22	39	in	in	IN
cord-277355-si3g5dih	22	40	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	22	41	research	research	NN
cord-277355-si3g5dih	22	42	.	.	.
cord-277355-si3g5dih	23	1	The	the	DT
cord-277355-si3g5dih	23	2	mature	mature	JJ
cord-277355-si3g5dih	23	3	CP	cp	NN
cord-277355-si3g5dih	23	4	is	be	VBZ
cord-277355-si3g5dih	23	5	approximately	approximately	RB
cord-277355-si3g5dih	23	6	100	100	CD
cord-277355-si3g5dih	23	7	amino	amino	JJ
cord-277355-si3g5dih	23	8	acids	acid	NNS
cord-277355-si3g5dih	23	9	in	in	IN
cord-277355-si3g5dih	23	10	length	length	NN
cord-277355-si3g5dih	23	11	.	.	.
cord-277355-si3g5dih	24	1	Although	although	IN
cord-277355-si3g5dih	24	2	the	the	DT
cord-277355-si3g5dih	24	3	amino	amino	NN
cord-277355-si3g5dih	24	4	acid	acid	NN
cord-277355-si3g5dih	24	5	sequences	sequence	NNS
cord-277355-si3g5dih	24	6	of	of	IN
cord-277355-si3g5dih	24	7	CPs	cp	NNS
cord-277355-si3g5dih	24	8	are	be	VBP
cord-277355-si3g5dih	24	9	not	not	RB
cord-277355-si3g5dih	24	10	very	very	RB
cord-277355-si3g5dih	24	11	conserved	conserved	JJ
cord-277355-si3g5dih	24	12	among	among	IN
cord-277355-si3g5dih	24	13	the	the	DT
cord-277355-si3g5dih	24	14	Flavivirus	Flavivirus	NNP
cord-277355-si3g5dih	24	15	genus	genus	NN
cord-277355-si3g5dih	24	16	(	(	-LRB-
cord-277355-si3g5dih	24	17	Fig	Fig	NNP
cord-277355-si3g5dih	24	18	.	.	.
cord-277355-si3g5dih	24	19	1A	1a	NN
cord-277355-si3g5dih	24	20	)	)	-RRB-
cord-277355-si3g5dih	24	21	,	,	,
cord-277355-si3g5dih	24	22	similar	similar	JJ
cord-277355-si3g5dih	24	23	structures	structure	NNS
cord-277355-si3g5dih	24	24	and	and	CC
cord-277355-si3g5dih	24	25	properties	property	NNS
cord-277355-si3g5dih	24	26	are	be	VBP
cord-277355-si3g5dih	24	27	shared	share	VBN
cord-277355-si3g5dih	24	28	by	by	IN
cord-277355-si3g5dih	24	29	all	all	DT
cord-277355-si3g5dih	24	30	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	24	31	CPs	CPs	NNP
cord-277355-si3g5dih	24	32	.	.	.
cord-277355-si3g5dih	25	1	Approximately	approximately	RB
cord-277355-si3g5dih	25	2	one	one	CD
cord-277355-si3g5dih	25	3	-	-	HYPH
cord-277355-si3g5dih	25	4	quarter	quarter	NN
cord-277355-si3g5dih	25	5	of	of	IN
cord-277355-si3g5dih	25	6	the	the	DT
cord-277355-si3g5dih	25	7	residues	residue	NNS
cord-277355-si3g5dih	25	8	are	be	VBP
cord-277355-si3g5dih	25	9	basic	basic	JJ
cord-277355-si3g5dih	25	10	and	and	CC
cord-277355-si3g5dih	25	11	mainly	mainly	RB
cord-277355-si3g5dih	25	12	cluster	cluster	JJ
cord-277355-si3g5dih	25	13	at	at	IN
cord-277355-si3g5dih	25	14	the	the	DT
cord-277355-si3g5dih	25	15	N	n	CD
cord-277355-si3g5dih	25	16	-	-	HYPH
cord-277355-si3g5dih	25	17	terminus	terminus	NN
cord-277355-si3g5dih	25	18	and	and	CC
cord-277355-si3g5dih	25	19	Cterminus	Cterminus	NNP
cord-277355-si3g5dih	25	20	;	;	:
cord-277355-si3g5dih	25	21	this	this	DT
cord-277355-si3g5dih	25	22	property	property	NN
cord-277355-si3g5dih	25	23	is	be	VBZ
cord-277355-si3g5dih	25	24	in	in	IN
cord-277355-si3g5dih	25	25	accordance	accordance	NN
cord-277355-si3g5dih	25	26	with	with	IN
cord-277355-si3g5dih	25	27	their	-PRON-	PRP$
cord-277355-si3g5dih	25	28	function	function	NN
cord-277355-si3g5dih	25	29	in	in	IN
cord-277355-si3g5dih	25	30	the	the	DT
cord-277355-si3g5dih	25	31	vRNA	vrna	JJ
cord-277355-si3g5dih	25	32	package	package	NN
cord-277355-si3g5dih	25	33	.	.	.
cord-277355-si3g5dih	26	1	Moreover	moreover	RB
cord-277355-si3g5dih	26	2	,	,	,
cord-277355-si3g5dih	26	3	there	there	EX
cord-277355-si3g5dih	26	4	is	be	VBZ
cord-277355-si3g5dih	26	5	a	a	DT
cord-277355-si3g5dih	26	6	characteristic	characteristic	JJ
cord-277355-si3g5dih	26	7	region	region	NN
cord-277355-si3g5dih	26	8	predominately	predominately	RB
cord-277355-si3g5dih	26	9	composed	compose	VBN
cord-277355-si3g5dih	26	10	of	of	IN
cord-277355-si3g5dih	26	11	hydrophobic	hydrophobic	JJ
cord-277355-si3g5dih	26	12	residues	residue	NNS
cord-277355-si3g5dih	26	13	in	in	IN
cord-277355-si3g5dih	26	14	all	all	DT
cord-277355-si3g5dih	26	15	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	26	16	CPs	CPs	NNP
cord-277355-si3g5dih	26	17	,	,	,
cord-277355-si3g5dih	26	18	called	call	VBD
cord-277355-si3g5dih	26	19	the	the	DT
cord-277355-si3g5dih	26	20	'	'	``
cord-277355-si3g5dih	26	21	'	'	``
cord-277355-si3g5dih	26	22	central	central	JJ
cord-277355-si3g5dih	26	23	hydrophobic	hydrophobic	JJ
cord-277355-si3g5dih	26	24	domain	domain	NN
cord-277355-si3g5dih	26	25	"	"	''
cord-277355-si3g5dih	26	26	(	(	-LRB-
cord-277355-si3g5dih	26	27	Fig	fig	NN
cord-277355-si3g5dih	26	28	.	.	.
cord-277355-si3g5dih	26	29	1A	1a	LS
cord-277355-si3g5dih	26	30	)	)	-RRB-
cord-277355-si3g5dih	26	31	[	[	-LRB-
cord-277355-si3g5dih	26	32	8	8	CD
cord-277355-si3g5dih	26	33	]	]	-RRB-
cord-277355-si3g5dih	26	34	,	,	,
cord-277355-si3g5dih	26	35	which	which	WDT
cord-277355-si3g5dih	26	36	has	have	VBZ
cord-277355-si3g5dih	26	37	been	be	VBN
cord-277355-si3g5dih	26	38	proven	prove	VBN
cord-277355-si3g5dih	26	39	to	to	TO
cord-277355-si3g5dih	26	40	play	play	VB
cord-277355-si3g5dih	26	41	an	an	DT
cord-277355-si3g5dih	26	42	essential	essential	JJ
cord-277355-si3g5dih	26	43	role	role	NN
cord-277355-si3g5dih	26	44	in	in	IN
cord-277355-si3g5dih	26	45	viral	viral	JJ
cord-277355-si3g5dih	26	46	assembly	assembly	NN
cord-277355-si3g5dih	26	47	[	[	-LRB-
cord-277355-si3g5dih	26	48	9	9	CD
cord-277355-si3g5dih	26	49	]	]	-RRB-
cord-277355-si3g5dih	26	50	.	.	.
cord-277355-si3g5dih	27	1	The	the	DT
cord-277355-si3g5dih	27	2	structures	structure	NNS
cord-277355-si3g5dih	27	3	of	of	IN
cord-277355-si3g5dih	27	4	the	the	DT
cord-277355-si3g5dih	27	5	DENV	DENV	NNP
cord-277355-si3g5dih	27	6	,	,	,
cord-277355-si3g5dih	27	7	WNV	WNV	NNP
cord-277355-si3g5dih	27	8	(	(	-LRB-
cord-277355-si3g5dih	27	9	Kunjin	Kunjin	NNP
cord-277355-si3g5dih	27	10	subtype	subtype	NN
cord-277355-si3g5dih	27	11	)	)	-RRB-
cord-277355-si3g5dih	27	12	,	,	,
cord-277355-si3g5dih	27	13	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	27	14	and	and	CC
cord-277355-si3g5dih	27	15	JEV	JEV	NNP
cord-277355-si3g5dih	27	16	CPs	cp	NNS
cord-277355-si3g5dih	27	17	have	have	VBP
cord-277355-si3g5dih	27	18	been	be	VBN
cord-277355-si3g5dih	27	19	resolved	resolve	VBN
cord-277355-si3g5dih	27	20	by	by	IN
cord-277355-si3g5dih	27	21	different	different	JJ
cord-277355-si3g5dih	27	22	methods	method	NNS
cord-277355-si3g5dih	27	23	[	[	-LRB-
cord-277355-si3g5dih	27	24	10	10	CD
cord-277355-si3g5dih	27	25	]	]	-RRB-
cord-277355-si3g5dih	27	26	[	[	-LRB-
cord-277355-si3g5dih	27	27	11	11	CD
cord-277355-si3g5dih	27	28	]	]	-RRB-
cord-277355-si3g5dih	27	29	[	[	-LRB-
cord-277355-si3g5dih	27	30	12	12	CD
cord-277355-si3g5dih	27	31	]	]	-RRB-
cord-277355-si3g5dih	27	32	[	[	-LRB-
cord-277355-si3g5dih	27	33	13	13	CD
cord-277355-si3g5dih	27	34	]	]	-RRB-
cord-277355-si3g5dih	28	1	[	[	-LRB-
cord-277355-si3g5dih	28	2	14	14	CD
cord-277355-si3g5dih	28	3	]	]	-RRB-
cord-277355-si3g5dih	28	4	[	[	-LRB-
cord-277355-si3g5dih	28	5	15	15	CD
cord-277355-si3g5dih	28	6	]	]	-RRB-
cord-277355-si3g5dih	28	7	.	.	.
cord-277355-si3g5dih	29	1	All	all	PDT
cord-277355-si3g5dih	29	2	the	the	DT
cord-277355-si3g5dih	29	3	determined	determined	JJ
cord-277355-si3g5dih	29	4	structures	structure	NNS
cord-277355-si3g5dih	29	5	reveal	reveal	VBP
cord-277355-si3g5dih	29	6	that	that	IN
cord-277355-si3g5dih	29	7	CP	CP	NNP
cord-277355-si3g5dih	29	8	is	be	VBZ
cord-277355-si3g5dih	29	9	dimeric	dimeric	JJ
cord-277355-si3g5dih	29	10	(	(	-LRB-
cord-277355-si3g5dih	29	11	Fig	fig	NN
cord-277355-si3g5dih	29	12	.	.	.
cord-277355-si3g5dih	29	13	1B	1b	LS
cord-277355-si3g5dih	29	14	)	)	-RRB-
cord-277355-si3g5dih	29	15	and	and	CC
cord-277355-si3g5dih	29	16	that	that	IN
cord-277355-si3g5dih	29	17	each	each	DT
cord-277355-si3g5dih	29	18	monomer	monomer	NN
cord-277355-si3g5dih	29	19	contains	contain	VBZ
cord-277355-si3g5dih	29	20	4	4	CD
cord-277355-si3g5dih	29	21	distinct	distinct	JJ
cord-277355-si3g5dih	29	22	a	a	DT
cord-277355-si3g5dih	29	23	-	-	HYPH
cord-277355-si3g5dih	29	24	helices	helix	NNS
cord-277355-si3g5dih	29	25	(	(	-LRB-
cord-277355-si3g5dih	29	26	termed	term	VBN
cord-277355-si3g5dih	29	27	a1-a4	a1-a4	NNP
cord-277355-si3g5dih	29	28	,	,	,
cord-277355-si3g5dih	29	29	they	-PRON-	PRP
cord-277355-si3g5dih	29	30	are	be	VBP
cord-277355-si3g5dih	29	31	connected	connect	VBN
cord-277355-si3g5dih	29	32	by	by	IN
cord-277355-si3g5dih	29	33	loops	loop	NNS
cord-277355-si3g5dih	29	34	)	)	-RRB-
cord-277355-si3g5dih	29	35	,	,	,
cord-277355-si3g5dih	29	36	but	but	CC
cord-277355-si3g5dih	29	37	its	-PRON-	PRP$
cord-277355-si3g5dih	29	38	N	n	CD
cord-277355-si3g5dih	29	39	-	-	HYPH
cord-277355-si3g5dih	29	40	terminus	terminus	NN
cord-277355-si3g5dih	29	41	(	(	-LRB-
cord-277355-si3g5dih	29	42	approximately	approximately	RB
cord-277355-si3g5dih	29	43	20	20	CD
cord-277355-si3g5dih	29	44	aa	aa	NNP
cord-277355-si3g5dih	29	45	)	)	-RRB-
cord-277355-si3g5dih	29	46	is	be	VBZ
cord-277355-si3g5dih	29	47	intrinsically	intrinsically	RB
cord-277355-si3g5dih	29	48	disordered	disordered	JJ
cord-277355-si3g5dih	29	49	[	[	-LRB-
cord-277355-si3g5dih	29	50	11	11	CD
cord-277355-si3g5dih	29	51	,	,	,
cord-277355-si3g5dih	29	52	14	14	CD
cord-277355-si3g5dih	29	53	]	]	-RRB-
cord-277355-si3g5dih	29	54	.	.	.
cord-277355-si3g5dih	30	1	The	the	DT
cord-277355-si3g5dih	30	2	homodimers	homodimer	NNS
cord-277355-si3g5dih	30	3	are	be	VBP
cord-277355-si3g5dih	30	4	connected	connect	VBN
cord-277355-si3g5dih	30	5	mainly	mainly	RB
cord-277355-si3g5dih	30	6	by	by	IN
cord-277355-si3g5dih	30	7	extensive	extensive	JJ
cord-277355-si3g5dih	30	8	hydrophobic	hydrophobic	JJ
cord-277355-si3g5dih	30	9	interactions	interaction	NNS
cord-277355-si3g5dih	30	10	and	and	CC
cord-277355-si3g5dih	30	11	hydrogen	hydrogen	NN
cord-277355-si3g5dih	30	12	bonds	bond	NNS
cord-277355-si3g5dih	30	13	[	[	-LRB-
cord-277355-si3g5dih	30	14	10	10	CD
cord-277355-si3g5dih	30	15	,	,	,
cord-277355-si3g5dih	30	16	13	13	CD
cord-277355-si3g5dih	30	17	,	,	,
cord-277355-si3g5dih	30	18	14	14	CD
cord-277355-si3g5dih	30	19	]	]	-RRB-
cord-277355-si3g5dih	30	20	.	.	.
cord-277355-si3g5dih	31	1	All	all	DT
cord-277355-si3g5dih	31	2	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	31	3	CP	CP	NNP
cord-277355-si3g5dih	31	4	homodimers	homodimer	NNS
cord-277355-si3g5dih	31	5	contain	contain	VBP
cord-277355-si3g5dih	31	6	at	at	IN
cord-277355-si3g5dih	31	7	least	least	RBS
cord-277355-si3g5dih	31	8	two	two	CD
cord-277355-si3g5dih	31	9	layers	layer	NNS
cord-277355-si3g5dih	31	10	of	of	IN
cord-277355-si3g5dih	31	11	contact	contact	NN
cord-277355-si3g5dih	31	12	interface	interface	NN
cord-277355-si3g5dih	31	13	.	.	.
cord-277355-si3g5dih	32	1	The	the	DT
cord-277355-si3g5dih	32	2	a2-a2	a2-a2	JJ
cord-277355-si3g5dih	32	3	0	0	CD
cord-277355-si3g5dih	32	4	interface	interface	NN
cord-277355-si3g5dih	32	5	forms	form	VBZ
cord-277355-si3g5dih	32	6	the	the	DT
cord-277355-si3g5dih	32	7	bottom	bottom	NN
cord-277355-si3g5dih	32	8	of	of	IN
cord-277355-si3g5dih	32	9	a	a	DT
cord-277355-si3g5dih	32	10	hydrophobic	hydrophobic	JJ
cord-277355-si3g5dih	32	11	cleft	cleft	NN
cord-277355-si3g5dih	32	12	(	(	-LRB-
cord-277355-si3g5dih	32	13	Fig	Fig	NNP
cord-277355-si3g5dih	32	14	.	.	.
cord-277355-si3g5dih	32	15	1B	1b	LS
cord-277355-si3g5dih	32	16	)	)	-RRB-
cord-277355-si3g5dih	32	17	that	that	WDT
cord-277355-si3g5dih	32	18	is	be	VBZ
cord-277355-si3g5dih	32	19	crucial	crucial	JJ
cord-277355-si3g5dih	32	20	for	for	IN
cord-277355-si3g5dih	32	21	viral	viral	JJ
cord-277355-si3g5dih	32	22	association	association	NN
cord-277355-si3g5dih	32	23	with	with	IN
cord-277355-si3g5dih	32	24	biological	biological	JJ
cord-277355-si3g5dih	32	25	membranes	membrane	NNS
cord-277355-si3g5dih	32	26	[	[	-LRB-
cord-277355-si3g5dih	32	27	10	10	CD
cord-277355-si3g5dih	32	28	]	]	-RRB-
cord-277355-si3g5dih	32	29	and	and	CC
cord-277355-si3g5dih	32	30	lipid	lipid	NN
cord-277355-si3g5dih	32	31	droplets	droplet	NNS
cord-277355-si3g5dih	32	32	(	(	-LRB-
cord-277355-si3g5dih	32	33	LDs	LDs	NNP
cord-277355-si3g5dih	32	34	)	)	-RRB-
cord-277355-si3g5dih	32	35	(	(	-LRB-
cord-277355-si3g5dih	32	36	Fig	Fig	NNP
cord-277355-si3g5dih	32	37	.	.	.
cord-277355-si3g5dih	32	38	1C	1C	NNP
cord-277355-si3g5dih	32	39	)	)	-RRB-
cord-277355-si3g5dih	32	40	[	[	-LRB-
cord-277355-si3g5dih	32	41	16	16	CD
cord-277355-si3g5dih	32	42	]	]	-RRB-
cord-277355-si3g5dih	32	43	.	.	.
cord-277355-si3g5dih	33	1	The	the	DT
cord-277355-si3g5dih	33	2	longest	long	JJS
cord-277355-si3g5dih	33	3	helix	helix	NN
cord-277355-si3g5dih	33	4	pair	pair	NN
cord-277355-si3g5dih	33	5	,	,	,
cord-277355-si3g5dih	33	6	a4-a4	a4-a4	NNP
cord-277355-si3g5dih	33	7	0	0	NFP
cord-277355-si3g5dih	33	8	,	,	,
cord-277355-si3g5dih	33	9	is	be	VBZ
cord-277355-si3g5dih	33	10	at	at	IN
cord-277355-si3g5dih	33	11	the	the	DT
cord-277355-si3g5dih	33	12	bottom	bottom	NN
cord-277355-si3g5dih	33	13	of	of	IN
cord-277355-si3g5dih	33	14	the	the	DT
cord-277355-si3g5dih	33	15	homodimer	homodimer	JJ
cord-277355-si3g5dih	33	16	and	and	CC
cord-277355-si3g5dih	33	17	forms	form	VBZ
cord-277355-si3g5dih	33	18	an	an	DT
cord-277355-si3g5dih	33	19	interface	interface	NN
cord-277355-si3g5dih	33	20	with	with	IN
cord-277355-si3g5dih	33	21	a	a	DT
cord-277355-si3g5dih	33	22	high	high	JJ
cord-277355-si3g5dih	33	23	density	density	NN
cord-277355-si3g5dih	33	24	of	of	IN
cord-277355-si3g5dih	33	25	positive	positive	JJ
cord-277355-si3g5dih	33	26	charges	charge	NNS
cord-277355-si3g5dih	33	27	,	,	,
cord-277355-si3g5dih	33	28	and	and	CC
cord-277355-si3g5dih	33	29	this	this	DT
cord-277355-si3g5dih	33	30	interface	interface	NN
cord-277355-si3g5dih	33	31	is	be	VBZ
cord-277355-si3g5dih	33	32	proposed	propose	VBN
cord-277355-si3g5dih	33	33	as	as	IN
cord-277355-si3g5dih	33	34	the	the	DT
cord-277355-si3g5dih	33	35	vRNAbinding	vrnabinding	NN
cord-277355-si3g5dih	33	36	site	site	NN
cord-277355-si3g5dih	33	37	(	(	-LRB-
cord-277355-si3g5dih	33	38	Fig	Fig	NNP
cord-277355-si3g5dih	33	39	.	.	.
cord-277355-si3g5dih	33	40	1C	1C	NNP
cord-277355-si3g5dih	33	41	)	)	-RRB-
cord-277355-si3g5dih	33	42	[	[	-LRB-
cord-277355-si3g5dih	33	43	10	10	CD
cord-277355-si3g5dih	33	44	,	,	,
cord-277355-si3g5dih	33	45	13	13	CD
cord-277355-si3g5dih	33	46	]	]	-RRB-
cord-277355-si3g5dih	33	47	;	;	:
cord-277355-si3g5dih	33	48	the	the	DT
cord-277355-si3g5dih	33	49	a4-a4	a4-a4	NNP
cord-277355-si3g5dih	33	50	0	0	CD
cord-277355-si3g5dih	33	51	pairs	pair	NNS
cord-277355-si3g5dih	33	52	also	also	RB
cord-277355-si3g5dih	33	53	affect	affect	VBP
cord-277355-si3g5dih	33	54	protein	protein	NN
cord-277355-si3g5dih	33	55	stability	stability	NN
cord-277355-si3g5dih	33	56	and	and	CC
cord-277355-si3g5dih	33	57	overall	overall	JJ
cord-277355-si3g5dih	33	58	conformation	conformation	NN
cord-277355-si3g5dih	33	59	[	[	-LRB-
cord-277355-si3g5dih	33	60	17	17	CD
cord-277355-si3g5dih	33	61	]	]	-RRB-
cord-277355-si3g5dih	33	62	.	.	.
cord-277355-si3g5dih	34	1	The	the	DT
cord-277355-si3g5dih	34	2	N	N	NNP
cord-277355-si3g5dih	34	3	-	-	HYPH
cord-277355-si3g5dih	34	4	terminus	terminus	NN
cord-277355-si3g5dih	34	5	and	and	CC
cord-277355-si3g5dih	34	6	a1-helix	a1-helix	NNP
cord-277355-si3g5dih	34	7	of	of	IN
cord-277355-si3g5dih	34	8	CPs	cp	NNS
cord-277355-si3g5dih	34	9	are	be	VBP
cord-277355-si3g5dih	34	10	very	very	RB
cord-277355-si3g5dih	34	11	flexible	flexible	JJ
cord-277355-si3g5dih	34	12	among	among	IN
cord-277355-si3g5dih	34	13	the	the	DT
cord-277355-si3g5dih	34	14	Flavivirus	Flavivirus	NNP
cord-277355-si3g5dih	34	15	genus	genus	NN
cord-277355-si3g5dih	34	16	,	,	,
cord-277355-si3g5dih	34	17	which	which	WDT
cord-277355-si3g5dih	34	18	may	may	MD
cord-277355-si3g5dih	34	19	help	help	VB
cord-277355-si3g5dih	34	20	them	-PRON-	PRP
cord-277355-si3g5dih	34	21	to	to	TO
cord-277355-si3g5dih	34	22	adopt	adopt	VB
cord-277355-si3g5dih	34	23	different	different	JJ
cord-277355-si3g5dih	34	24	conformations	conformation	NNS
cord-277355-si3g5dih	34	25	for	for	IN
cord-277355-si3g5dih	34	26	various	various	JJ
cord-277355-si3g5dih	34	27	physiological	physiological	JJ
cord-277355-si3g5dih	34	28	processes	process	NNS
cord-277355-si3g5dih	34	29	[	[	-LRB-
cord-277355-si3g5dih	34	30	12	12	CD
cord-277355-si3g5dih	34	31	,	,	,
cord-277355-si3g5dih	34	32	15	15	CD
cord-277355-si3g5dih	34	33	]	]	-RRB-
cord-277355-si3g5dih	34	34	.	.	.
cord-277355-si3g5dih	35	1	The	the	DT
cord-277355-si3g5dih	35	2	a1	a1	NN
cord-277355-si3g5dih	35	3	of	of	IN
cord-277355-si3g5dih	35	4	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	35	5	CP	CP	NNP
cord-277355-si3g5dih	35	6	is	be	VBZ
cord-277355-si3g5dih	35	7	much	much	RB
cord-277355-si3g5dih	35	8	shorter	short	JJR
cord-277355-si3g5dih	35	9	than	than	IN
cord-277355-si3g5dih	35	10	that	that	DT
cord-277355-si3g5dih	35	11	of	of	IN
cord-277355-si3g5dih	35	12	other	other	JJ
cord-277355-si3g5dih	35	13	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	35	14	CPs	cp	NNS
cord-277355-si3g5dih	35	15	but	but	CC
cord-277355-si3g5dih	35	16	has	have	VBZ
cord-277355-si3g5dih	35	17	a	a	DT
cord-277355-si3g5dih	35	18	unique	unique	JJ
cord-277355-si3g5dih	35	19	long	long	JJ
cord-277355-si3g5dih	35	20	pre	pre	JJ
cord-277355-si3g5dih	35	21	-	-	JJ
cord-277355-si3g5dih	35	22	a1	a1	JJ
cord-277355-si3g5dih	35	23	loop	loop	NN
cord-277355-si3g5dih	35	24	.	.	.
cord-277355-si3g5dih	36	1	The	the	DT
cord-277355-si3g5dih	36	2	orientation	orientation	NN
cord-277355-si3g5dih	36	3	of	of	IN
cord-277355-si3g5dih	36	4	the	the	DT
cord-277355-si3g5dih	36	5	a1	a1	NN
cord-277355-si3g5dih	36	6	of	of	IN
cord-277355-si3g5dih	36	7	DENV	DENV	NNP
cord-277355-si3g5dih	36	8	CP	CP	NNP
cord-277355-si3g5dih	36	9	is	be	VBZ
cord-277355-si3g5dih	36	10	different	different	JJ
cord-277355-si3g5dih	36	11	from	from	IN
cord-277355-si3g5dih	36	12	that	that	DT
cord-277355-si3g5dih	36	13	of	of	IN
cord-277355-si3g5dih	36	14	others	other	NNS
cord-277355-si3g5dih	36	15	[	[	-LRB-
cord-277355-si3g5dih	36	16	14	14	CD
cord-277355-si3g5dih	36	17	]	]	-RRB-
cord-277355-si3g5dih	36	18	.	.	.
cord-277355-si3g5dih	37	1	The	the	DT
cord-277355-si3g5dih	37	2	third	third	JJ
cord-277355-si3g5dih	37	3	layer	layer	NN
cord-277355-si3g5dih	37	4	of	of	IN
cord-277355-si3g5dih	37	5	the	the	DT
cord-277355-si3g5dih	37	6	contact	contact	NN
cord-277355-si3g5dih	37	7	interface	interface	NN
cord-277355-si3g5dih	37	8	on	on	IN
cord-277355-si3g5dih	37	9	the	the	DT
cord-277355-si3g5dih	37	10	top	top	NN
cord-277355-si3g5dih	37	11	of	of	IN
cord-277355-si3g5dih	37	12	the	the	DT
cord-277355-si3g5dih	37	13	dimer	dimer	NN
cord-277355-si3g5dih	37	14	structures	structure	NNS
cord-277355-si3g5dih	37	15	,	,	,
cord-277355-si3g5dih	37	16	which	which	WDT
cord-277355-si3g5dih	37	17	is	be	VBZ
cord-277355-si3g5dih	37	18	formed	form	VBN
cord-277355-si3g5dih	37	19	by	by	IN
cord-277355-si3g5dih	37	20	antiparallel	antiparallel	NN
cord-277355-si3g5dih	37	21	(	(	-LRB-
cord-277355-si3g5dih	37	22	WNV	WNV	NNP
cord-277355-si3g5dih	37	23	and	and	CC
cord-277355-si3g5dih	37	24	JEV	JEV	NNP
cord-277355-si3g5dih	37	25	)	)	-RRB-
cord-277355-si3g5dih	38	1	a1-a1	a1-a1	LS
cord-277355-si3g5dih	38	2	0	0	CD
cord-277355-si3g5dih	38	3	[	[	-LRB-
cord-277355-si3g5dih	38	4	12	12	CD
cord-277355-si3g5dih	38	5	,	,	,
cord-277355-si3g5dih	38	6	14	14	CD
cord-277355-si3g5dih	38	7	]	]	-RRB-
cord-277355-si3g5dih	38	8	or	or	CC
cord-277355-si3g5dih	38	9	(	(	-LRB-
cord-277355-si3g5dih	38	10	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	38	11	)	)	-RRB-
cord-277355-si3g5dih	38	12	a1-a1	a1-a1	NN
cord-277355-si3g5dih	38	13	0	0	CD
cord-277355-si3g5dih	38	14	with	with	IN
cord-277355-si3g5dih	38	15	pre	pre	JJ
cord-277355-si3g5dih	38	16	-	-	JJ
cord-277355-si3g5dih	38	17	a1-pre	a1-pre	JJ
cord-277355-si3g5dih	38	18	-	-	HYPH
cord-277355-si3g5dih	38	19	a1	a1	NN
cord-277355-si3g5dih	38	20	0	0	CD
cord-277355-si3g5dih	38	21	loops	loop	NNS
cord-277355-si3g5dih	38	22	[	[	-LRB-
cord-277355-si3g5dih	38	23	11	11	CD
cord-277355-si3g5dih	38	24	,	,	,
cord-277355-si3g5dih	38	25	13	13	CD
cord-277355-si3g5dih	38	26	,	,	,
cord-277355-si3g5dih	38	27	15	15	CD
cord-277355-si3g5dih	38	28	]	]	-RRB-
cord-277355-si3g5dih	38	29	that	that	WDT
cord-277355-si3g5dih	38	30	occlude	occlude	VBP
cord-277355-si3g5dih	38	31	the	the	DT
cord-277355-si3g5dih	38	32	a2-a2	a2-a2	JJ
cord-277355-si3g5dih	38	33	0	0	CD
cord-277355-si3g5dih	38	34	hydrophobic	hydrophobic	JJ
cord-277355-si3g5dih	38	35	cleft	cleft	NN
cord-277355-si3g5dih	38	36	and	and	CC
cord-277355-si3g5dih	38	37	form	form	VB
cord-277355-si3g5dih	38	38	a	a	DT
cord-277355-si3g5dih	38	39	closed	closed	JJ
cord-277355-si3g5dih	38	40	conformation	conformation	NN
cord-277355-si3g5dih	38	41	,	,	,
cord-277355-si3g5dih	38	42	except	except	IN
cord-277355-si3g5dih	38	43	the	the	DT
cord-277355-si3g5dih	38	44	DENV	DENV	NNP
cord-277355-si3g5dih	38	45	CP	cp	NN
cord-277355-si3g5dih	38	46	dimer	dimer	NN
cord-277355-si3g5dih	38	47	.	.	.
cord-277355-si3g5dih	39	1	By	by	IN
cord-277355-si3g5dih	39	2	contrast	contrast	NN
cord-277355-si3g5dih	39	3	,	,	,
cord-277355-si3g5dih	39	4	the	the	DT
cord-277355-si3g5dih	39	5	a1	a1	NNP
cord-277355-si3g5dih	39	6	and	and	CC
cord-277355-si3g5dih	39	7	a1	a1	NNP
cord-277355-si3g5dih	39	8	0	0	CD
cord-277355-si3g5dih	39	9	-helices	-helices	CD
cord-277355-si3g5dih	39	10	of	of	IN
cord-277355-si3g5dih	39	11	the	the	DT
cord-277355-si3g5dih	39	12	DENV	DENV	NNP
cord-277355-si3g5dih	39	13	CP	CP	NNP
cord-277355-si3g5dih	39	14	dimer	dimer	NN
cord-277355-si3g5dih	39	15	form	form	VBP
cord-277355-si3g5dih	39	16	an	an	DT
cord-277355-si3g5dih	39	17	open	open	JJ
cord-277355-si3g5dih	39	18	conformation	conformation	NN
cord-277355-si3g5dih	39	19	without	without	IN
cord-277355-si3g5dih	39	20	pairing	pair	VBG
cord-277355-si3g5dih	39	21	,	,	,
cord-277355-si3g5dih	39	22	exposing	expose	VBG
cord-277355-si3g5dih	39	23	the	the	DT
cord-277355-si3g5dih	39	24	a2-a2	a2-a2	JJ
cord-277355-si3g5dih	39	25	0	0	CD
cord-277355-si3g5dih	39	26	hydrophobic	hydrophobic	JJ
cord-277355-si3g5dih	39	27	cleft	cleft	NN
cord-277355-si3g5dih	39	28	(	(	-LRB-
cord-277355-si3g5dih	39	29	Fig	Fig	NNP
cord-277355-si3g5dih	39	30	.	.	.
cord-277355-si3g5dih	39	31	1B	1b	CD
cord-277355-si3g5dih	39	32	)	)	-RRB-
cord-277355-si3g5dih	39	33	.	.	.
cord-277355-si3g5dih	40	1	However	however	RB
cord-277355-si3g5dih	40	2	,	,	,
cord-277355-si3g5dih	40	3	it	-PRON-	PRP
cord-277355-si3g5dih	40	4	should	should	MD
cord-277355-si3g5dih	40	5	be	be	VB
cord-277355-si3g5dih	40	6	noted	note	VBN
cord-277355-si3g5dih	40	7	that	that	IN
cord-277355-si3g5dih	40	8	the	the	DT
cord-277355-si3g5dih	40	9	only	only	JJ
cord-277355-si3g5dih	40	10	structure	structure	NN
cord-277355-si3g5dih	40	11	of	of	IN
cord-277355-si3g5dih	40	12	the	the	DT
cord-277355-si3g5dih	40	13	DENV	DENV	NNP
cord-277355-si3g5dih	40	14	CP	CP	NNP
cord-277355-si3g5dih	40	15	was	be	VBD
cord-277355-si3g5dih	40	16	solved	solve	VBN
cord-277355-si3g5dih	40	17	by	by	IN
cord-277355-si3g5dih	40	18	NMR	NMR	NNP
cord-277355-si3g5dih	40	19	in	in	IN
cord-277355-si3g5dih	40	20	solution	solution	NN
cord-277355-si3g5dih	40	21	,	,	,
cord-277355-si3g5dih	40	22	which	which	WDT
cord-277355-si3g5dih	40	23	is	be	VBZ
cord-277355-si3g5dih	40	24	relatively	relatively	RB
cord-277355-si3g5dih	40	25	less	less	RBR
cord-277355-si3g5dih	40	26	stable	stable	JJ
cord-277355-si3g5dih	40	27	than	than	IN
cord-277355-si3g5dih	40	28	the	the	DT
cord-277355-si3g5dih	40	29	structures	structure	NNS
cord-277355-si3g5dih	40	30	of	of	IN
cord-277355-si3g5dih	40	31	the	the	DT
cord-277355-si3g5dih	40	32	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	40	33	,	,	,
cord-277355-si3g5dih	40	34	WNV	WNV	NNP
cord-277355-si3g5dih	40	35	and	and	CC
cord-277355-si3g5dih	40	36	JEV	JEV	NNP
cord-277355-si3g5dih	40	37	CPs	cp	NNS
cord-277355-si3g5dih	40	38	in	in	IN
cord-277355-si3g5dih	40	39	crystals	crystal	NNS
cord-277355-si3g5dih	40	40	.	.	.
cord-277355-si3g5dih	41	1	A	a	DT
cord-277355-si3g5dih	41	2	subsequent	subsequent	JJ
cord-277355-si3g5dih	41	3	study	study	NN
cord-277355-si3g5dih	41	4	confirmed	confirm	VBD
cord-277355-si3g5dih	41	5	that	that	IN
cord-277355-si3g5dih	41	6	the	the	DT
cord-277355-si3g5dih	41	7	DENV	DENV	NNP
cord-277355-si3g5dih	41	8	a2-a2	a2-a2	JJ
cord-277355-si3g5dih	41	9	0	0	CD
cord-277355-si3g5dih	41	10	interface	interface	NN
cord-277355-si3g5dih	41	11	is	be	VBZ
cord-277355-si3g5dih	41	12	in	in	IN
cord-277355-si3g5dih	41	13	conformation	conformation	NN
cord-277355-si3g5dih	41	14	exchange	exchange	NN
cord-277355-si3g5dih	41	15	in	in	IN
cord-277355-si3g5dih	41	16	the	the	DT
cord-277355-si3g5dih	41	17	free	free	JJ
cord-277355-si3g5dih	41	18	state	state	NN
cord-277355-si3g5dih	41	19	,	,	,
cord-277355-si3g5dih	41	20	interconverting	interconverte	VBG
cord-277355-si3g5dih	41	21	between	between	IN
cord-277355-si3g5dih	41	22	an	an	DT
cord-277355-si3g5dih	41	23	open	open	JJ
cord-277355-si3g5dih	41	24	and	and	CC
cord-277355-si3g5dih	41	25	a	a	DT
cord-277355-si3g5dih	41	26	closed	closed	JJ
cord-277355-si3g5dih	41	27	state	state	NN
cord-277355-si3g5dih	41	28	regulated	regulate	VBN
cord-277355-si3g5dih	41	29	by	by	IN
cord-277355-si3g5dih	41	30	the	the	DT
cord-277355-si3g5dih	41	31	flexible	flexible	JJ
cord-277355-si3g5dih	41	32	N	n	CD
cord-277355-si3g5dih	41	33	-	-	HYPH
cord-277355-si3g5dih	41	34	terminus	terminus	NN
cord-277355-si3g5dih	41	35	[	[	-LRB-
cord-277355-si3g5dih	41	36	18	18	CD
cord-277355-si3g5dih	41	37	]	]	-RRB-
cord-277355-si3g5dih	41	38	.	.	.
cord-277355-si3g5dih	42	1	Whether	whether	IN
cord-277355-si3g5dih	42	2	other	other	JJ
cord-277355-si3g5dih	42	3	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	42	4	CPs	cp	NNS
cord-277355-si3g5dih	42	5	also	also	RB
cord-277355-si3g5dih	42	6	employ	employ	VBP
cord-277355-si3g5dih	42	7	the	the	DT
cord-277355-si3g5dih	42	8	same	same	JJ
cord-277355-si3g5dih	42	9	mechanism	mechanism	NN
cord-277355-si3g5dih	42	10	for	for	IN
cord-277355-si3g5dih	42	11	different	different	JJ
cord-277355-si3g5dih	42	12	biological	biological	JJ
cord-277355-si3g5dih	42	13	processes	process	NNS
cord-277355-si3g5dih	42	14	is	be	VBZ
cord-277355-si3g5dih	42	15	still	still	RB
cord-277355-si3g5dih	42	16	unclear	unclear	JJ
cord-277355-si3g5dih	42	17	.	.	.
cord-277355-si3g5dih	43	1	In	in	IN
cord-277355-si3g5dih	43	2	addition	addition	NN
cord-277355-si3g5dih	43	3	,	,	,
cord-277355-si3g5dih	43	4	tetrameric	tetrameric	JJ
cord-277355-si3g5dih	43	5	and	and	CC
cord-277355-si3g5dih	43	6	hexameric	hexameric	JJ
cord-277355-si3g5dih	43	7	arrangements	arrangement	NNS
cord-277355-si3g5dih	43	8	are	be	VBP
cord-277355-si3g5dih	43	9	also	also	RB
cord-277355-si3g5dih	43	10	observed	observe	VBN
cord-277355-si3g5dih	43	11	in	in	IN
cord-277355-si3g5dih	43	12	the	the	DT
cord-277355-si3g5dih	43	13	WNV	WNV	NNP
cord-277355-si3g5dih	43	14	[	[	-LRB-
cord-277355-si3g5dih	43	15	12	12	CD
cord-277355-si3g5dih	43	16	]	]	-RRB-
cord-277355-si3g5dih	43	17	and	and	CC
cord-277355-si3g5dih	43	18	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	43	19	[	[	-LRB-
cord-277355-si3g5dih	43	20	13	13	CD
cord-277355-si3g5dih	43	21	]	]	-RRB-
cord-277355-si3g5dih	43	22	CP	cp	NN
cord-277355-si3g5dih	43	23	crystal	crystal	NN
cord-277355-si3g5dih	43	24	structures	structure	NNS
cord-277355-si3g5dih	43	25	,	,	,
cord-277355-si3g5dih	43	26	respectively	respectively	RB
cord-277355-si3g5dih	43	27	.	.	.
cord-277355-si3g5dih	44	1	It	-PRON-	PRP
cord-277355-si3g5dih	44	2	was	be	VBD
cord-277355-si3g5dih	44	3	assumed	assume	VBN
cord-277355-si3g5dih	44	4	that	that	IN
cord-277355-si3g5dih	44	5	the	the	DT
cord-277355-si3g5dih	44	6	functional	functional	JJ
cord-277355-si3g5dih	44	7	CP	cp	NN
cord-277355-si3g5dih	44	8	requires	require	VBZ
cord-277355-si3g5dih	44	9	a	a	DT
cord-277355-si3g5dih	44	10	highly	highly	RB
cord-277355-si3g5dih	44	11	organized	organize	VBN
cord-277355-si3g5dih	44	12	arrangement	arrangement	NN
cord-277355-si3g5dih	44	13	,	,	,
cord-277355-si3g5dih	44	14	and	and	CC
cord-277355-si3g5dih	44	15	major	major	JJ
cord-277355-si3g5dih	44	16	mutations	mutation	NNS
cord-277355-si3g5dih	44	17	that	that	WDT
cord-277355-si3g5dih	44	18	transform	transform	VBP
cord-277355-si3g5dih	44	19	its	-PRON-	PRP$
cord-277355-si3g5dih	44	20	structure	structure	NN
cord-277355-si3g5dih	44	21	abrogate	abrogate	VB
cord-277355-si3g5dih	44	22	its	-PRON-	PRP$
cord-277355-si3g5dih	44	23	functions	function	NNS
cord-277355-si3g5dih	44	24	[	[	-LRB-
cord-277355-si3g5dih	44	25	19	19	CD
cord-277355-si3g5dih	44	26	]	]	-RRB-
cord-277355-si3g5dih	44	27	.	.	.
cord-277355-si3g5dih	45	1	Unexpectedly	unexpectedly	RB
cord-277355-si3g5dih	45	2	,	,	,
cord-277355-si3g5dih	45	3	the	the	DT
cord-277355-si3g5dih	45	4	research	research	NN
cord-277355-si3g5dih	45	5	team	team	NN
cord-277355-si3g5dih	45	6	of	of	IN
cord-277355-si3g5dih	45	7	W.	W.	NNP
cord-277355-si3g5dih	45	8	Mandl	Mandl	NNP
cord-277355-si3g5dih	45	9	showed	show	VBD
cord-277355-si3g5dih	45	10	that	that	IN
cord-277355-si3g5dih	45	11	TBEV	TBEV	NNP
cord-277355-si3g5dih	45	12	CP	CP	NNP
cord-277355-si3g5dih	45	13	tolerated	tolerate	VBD
cord-277355-si3g5dih	45	14	large	large	JJ
cord-277355-si3g5dih	45	15	internal	internal	JJ
cord-277355-si3g5dih	45	16	deletions	deletion	NNS
cord-277355-si3g5dih	45	17	,	,	,
cord-277355-si3g5dih	45	18	and	and	CC
cord-277355-si3g5dih	45	19	the	the	DT
cord-277355-si3g5dih	45	20	generated	generate	VBN
cord-277355-si3g5dih	45	21	mutants	mutant	NNS
cord-277355-si3g5dih	45	22	could	could	MD
cord-277355-si3g5dih	45	23	be	be	VB
cord-277355-si3g5dih	45	24	divided	divide	VBN
cord-277355-si3g5dih	45	25	into	into	IN
cord-277355-si3g5dih	45	26	three	three	CD
cord-277355-si3g5dih	45	27	groups	group	NNS
cord-277355-si3g5dih	45	28	according	accord	VBG
cord-277355-si3g5dih	45	29	to	to	IN
cord-277355-si3g5dih	45	30	their	-PRON-	PRP$
cord-277355-si3g5dih	45	31	viability	viability	NN
cord-277355-si3g5dih	45	32	in	in	IN
cord-277355-si3g5dih	45	33	cell	cell	NN
cord-277355-si3g5dih	45	34	culture	culture	NN
cord-277355-si3g5dih	45	35	[	[	-LRB-
cord-277355-si3g5dih	45	36	9	9	CD
cord-277355-si3g5dih	45	37	,	,	,
cord-277355-si3g5dih	45	38	19	19	CD
cord-277355-si3g5dih	45	39	,	,	,
cord-277355-si3g5dih	45	40	20	20	CD
cord-277355-si3g5dih	45	41	]	]	-RRB-
cord-277355-si3g5dih	45	42	.	.	.
cord-277355-si3g5dih	46	1	For	for	IN
cord-277355-si3g5dih	46	2	the	the	DT
cord-277355-si3g5dih	46	3	first	first	JJ
cord-277355-si3g5dih	46	4	group	group	NN
cord-277355-si3g5dih	46	5	,	,	,
cord-277355-si3g5dih	46	6	mutant	mutant	JJ
cord-277355-si3g5dih	46	7	RNA	RNA	NNP
cord-277355-si3g5dih	46	8	could	could	MD
cord-277355-si3g5dih	46	9	generate	generate	VB
cord-277355-si3g5dih	46	10	viable	viable	JJ
cord-277355-si3g5dih	46	11	infectious	infectious	JJ
cord-277355-si3g5dih	46	12	viruses	virus	NNS
cord-277355-si3g5dih	46	13	,	,	,
cord-277355-si3g5dih	46	14	albeit	albeit	IN
cord-277355-si3g5dih	46	15	viral	viral	JJ
cord-277355-si3g5dih	46	16	growth	growth	NN
cord-277355-si3g5dih	46	17	was	be	VBD
cord-277355-si3g5dih	46	18	correspondingly	correspondingly	RB
cord-277355-si3g5dih	46	19	decreased	decrease	VBN
cord-277355-si3g5dih	46	20	[	[	-LRB-
cord-277355-si3g5dih	46	21	20	20	CD
cord-277355-si3g5dih	46	22	]	]	-RRB-
cord-277355-si3g5dih	46	23	.	.	.
cord-277355-si3g5dih	47	1	For	for	IN
cord-277355-si3g5dih	47	2	the	the	DT
cord-277355-si3g5dih	47	3	second	second	JJ
cord-277355-si3g5dih	47	4	group	group	NN
cord-277355-si3g5dih	47	5	,	,	,
cord-277355-si3g5dih	47	6	the	the	DT
cord-277355-si3g5dih	47	7	viral	viral	JJ
cord-277355-si3g5dih	47	8	production	production	NN
cord-277355-si3g5dih	47	9	of	of	IN
cord-277355-si3g5dih	47	10	mutants	mutant	NNS
cord-277355-si3g5dih	47	11	carrying	carry	VBG
cord-277355-si3g5dih	47	12	large	large	JJ
cord-277355-si3g5dih	47	13	deletions	deletion	NNS
cord-277355-si3g5dih	47	14	was	be	VBD
cord-277355-si3g5dih	47	15	completely	completely	RB
cord-277355-si3g5dih	47	16	or	or	CC
cord-277355-si3g5dih	47	17	nearly	nearly	RB
cord-277355-si3g5dih	47	18	abolished	abolish	VBN
cord-277355-si3g5dih	47	19	,	,	,
cord-277355-si3g5dih	47	20	but	but	CC
cord-277355-si3g5dih	47	21	pseudorevertants	pseudorevertant	NNS
cord-277355-si3g5dih	47	22	could	could	MD
cord-277355-si3g5dih	47	23	easily	easily	RB
cord-277355-si3g5dih	47	24	be	be	VB
cord-277355-si3g5dih	47	25	restored	restore	VBN
cord-277355-si3g5dih	47	26	by	by	IN
cord-277355-si3g5dih	47	27	spontaneous	spontaneous	JJ
cord-277355-si3g5dih	47	28	second	second	JJ
cord-277355-si3g5dih	47	29	-	-	HYPH
cord-277355-si3g5dih	47	30	site	site	NN
cord-277355-si3g5dih	47	31	mutations	mutation	NNS
cord-277355-si3g5dih	47	32	in	in	IN
cord-277355-si3g5dih	47	33	the	the	DT
cord-277355-si3g5dih	47	34	capsid	capsid	NN
cord-277355-si3g5dih	47	35	gene	gene	NN
cord-277355-si3g5dih	47	36	[	[	-LRB-
cord-277355-si3g5dih	47	37	9	9	CD
cord-277355-si3g5dih	47	38	]	]	-RRB-
cord-277355-si3g5dih	47	39	.	.	.
cord-277355-si3g5dih	48	1	For	for	IN
cord-277355-si3g5dih	48	2	the	the	DT
cord-277355-si3g5dih	48	3	third	third	JJ
cord-277355-si3g5dih	48	4	group	group	NN
cord-277355-si3g5dih	48	5	,	,	,
cord-277355-si3g5dih	48	6	viral	viral	JJ
cord-277355-si3g5dih	48	7	infection	infection	NN
cord-277355-si3g5dih	48	8	spread	spread	NN
cord-277355-si3g5dih	48	9	was	be	VBD
cord-277355-si3g5dih	48	10	irreplaceably	irreplaceably	RB
cord-277355-si3g5dih	48	11	abolished	abolish	VBN
cord-277355-si3g5dih	48	12	by	by	IN
cord-277355-si3g5dih	48	13	deletions	deletion	NNS
cord-277355-si3g5dih	48	14	that	that	WDT
cord-277355-si3g5dih	48	15	were	be	VBD
cord-277355-si3g5dih	48	16	too	too	RB
cord-277355-si3g5dih	48	17	large	large	JJ
cord-277355-si3g5dih	48	18	;	;	:
cord-277355-si3g5dih	48	19	these	these	DT
cord-277355-si3g5dih	48	20	mutants	mutant	NNS
cord-277355-si3g5dih	48	21	became	become	VBD
cord-277355-si3g5dih	48	22	noninfectious	noninfectious	JJ
cord-277355-si3g5dih	48	23	replicons	replicon	NNS
cord-277355-si3g5dih	48	24	that	that	WDT
cord-277355-si3g5dih	48	25	secreted	secrete	VBD
cord-277355-si3g5dih	48	26	only	only	RB
cord-277355-si3g5dih	48	27	subviral	subviral	JJ
cord-277355-si3g5dih	48	28	particles	particle	NNS
cord-277355-si3g5dih	48	29	(	(	-LRB-
cord-277355-si3g5dih	48	30	SVPs	svp	NNS
cord-277355-si3g5dih	48	31	)	)	-RRB-
cord-277355-si3g5dih	48	32	[	[	-LRB-
cord-277355-si3g5dih	48	33	19	19	CD
cord-277355-si3g5dih	48	34	,	,	,
cord-277355-si3g5dih	48	35	21	21	CD
cord-277355-si3g5dih	48	36	]	]	-RRB-
cord-277355-si3g5dih	48	37	.	.	.
cord-277355-si3g5dih	49	1	Consistent	consistent	JJ
cord-277355-si3g5dih	49	2	with	with	IN
cord-277355-si3g5dih	49	3	TBEV	TBEV	NNP
cord-277355-si3g5dih	49	4	CP	CP	NNP
cord-277355-si3g5dih	49	5	,	,	,
cord-277355-si3g5dih	49	6	it	-PRON-	PRP
cord-277355-si3g5dih	49	7	was	be	VBD
cord-277355-si3g5dih	49	8	demonstrated	demonstrate	VBN
cord-277355-si3g5dih	49	9	that	that	IN
cord-277355-si3g5dih	49	10	YFV	YFV	NNP
cord-277355-si3g5dih	49	11	CP	CP	NNP
cord-277355-si3g5dih	49	12	,	,	,
cord-277355-si3g5dih	49	13	with	with	IN
cord-277355-si3g5dih	49	14	nearly	nearly	RB
cord-277355-si3g5dih	49	15	40	40	CD
cord-277355-si3g5dih	49	16	aa	aa	NN
cord-277355-si3g5dih	49	17	in	in	IN
cord-277355-si3g5dih	49	18	the	the	DT
cord-277355-si3g5dih	49	19	Nterminus	Nterminus	NNP
cord-277355-si3g5dih	49	20	or	or	CC
cord-277355-si3g5dih	49	21	27	27	CD
cord-277355-si3g5dih	49	22	aa	aa	NN
cord-277355-si3g5dih	49	23	in	in	IN
cord-277355-si3g5dih	49	24	the	the	DT
cord-277355-si3g5dih	49	25	C	C	NNP
cord-277355-si3g5dih	49	26	-	-	HYPH
cord-277355-si3g5dih	49	27	terminus	terminus	NN
cord-277355-si3g5dih	49	28	,	,	,
cord-277355-si3g5dih	49	29	was	be	VBD
cord-277355-si3g5dih	49	30	still	still	RB
cord-277355-si3g5dih	49	31	functional	functional	JJ
cord-277355-si3g5dih	49	32	in	in	IN
cord-277355-si3g5dih	49	33	RNA	RNA	NNP
cord-277355-si3g5dih	49	34	packaging	packaging	NN
cord-277355-si3g5dih	49	35	[	[	-LRB-
cord-277355-si3g5dih	49	36	22	22	CD
cord-277355-si3g5dih	49	37	]	]	-RRB-
cord-277355-si3g5dih	49	38	.	.	.
cord-277355-si3g5dih	50	1	Similar	similar	JJ
cord-277355-si3g5dih	50	2	properties	property	NNS
cord-277355-si3g5dih	50	3	were	be	VBD
cord-277355-si3g5dih	50	4	also	also	RB
cord-277355-si3g5dih	50	5	observed	observe	VBN
cord-277355-si3g5dih	50	6	in	in	IN
cord-277355-si3g5dih	50	7	WNV	WNV	NNP
cord-277355-si3g5dih	50	8	;	;	:
cord-277355-si3g5dih	50	9	when	when	WRB
cord-277355-si3g5dih	50	10	even	even	RB
cord-277355-si3g5dih	50	11	36	36	CD
cord-277355-si3g5dih	50	12	or	or	CC
cord-277355-si3g5dih	50	13	37	37	CD
cord-277355-si3g5dih	50	14	residue	residue	NN
cord-277355-si3g5dih	50	15	deletions	deletion	NNS
cord-277355-si3g5dih	50	16	were	be	VBD
cord-277355-si3g5dih	50	17	introduced	introduce	VBN
cord-277355-si3g5dih	50	18	into	into	IN
cord-277355-si3g5dih	50	19	CP	CP	NNP
cord-277355-si3g5dih	50	20	by	by	IN
cord-277355-si3g5dih	50	21	reverse	reverse	JJ
cord-277355-si3g5dih	50	22	genetics	genetics	NN
cord-277355-si3g5dih	50	23	technology	technology	NN
cord-277355-si3g5dih	50	24	,	,	,
cord-277355-si3g5dih	50	25	these	these	DT
cord-277355-si3g5dih	50	26	mutants	mutant	NNS
cord-277355-si3g5dih	50	27	were	be	VBD
cord-277355-si3g5dih	50	28	still	still	RB
cord-277355-si3g5dih	50	29	viable	viable	JJ
cord-277355-si3g5dih	50	30	[	[	-LRB-
cord-277355-si3g5dih	50	31	23	23	CD
cord-277355-si3g5dih	50	32	]	]	-RRB-
cord-277355-si3g5dih	50	33	.	.	.
cord-277355-si3g5dih	51	1	These	these	DT
cord-277355-si3g5dih	51	2	results	result	NNS
cord-277355-si3g5dih	51	3	together	together	RB
cord-277355-si3g5dih	51	4	suggest	suggest	VBP
cord-277355-si3g5dih	51	5	the	the	DT
cord-277355-si3g5dih	51	6	remarkable	remarkable	JJ
cord-277355-si3g5dih	51	7	flexibility	flexibility	NN
cord-277355-si3g5dih	51	8	of	of	IN
cord-277355-si3g5dih	51	9	flaviviral	flaviviral	NNP
cord-277355-si3g5dih	51	10	CPs	cp	NNS
cord-277355-si3g5dih	51	11	in	in	IN
cord-277355-si3g5dih	51	12	both	both	DT
cord-277355-si3g5dih	51	13	structure	structure	NN
cord-277355-si3g5dih	51	14	and	and	CC
cord-277355-si3g5dih	51	15	function	function	NN
cord-277355-si3g5dih	51	16	.	.	.
cord-277355-si3g5dih	52	1	However	however	RB
cord-277355-si3g5dih	52	2	,	,	,
cord-277355-si3g5dih	52	3	all	all	DT
cord-277355-si3g5dih	52	4	of	of	IN
cord-277355-si3g5dih	52	5	these	these	DT
cord-277355-si3g5dih	52	6	viable	viable	JJ
cord-277355-si3g5dih	52	7	mutants	mutant	NNS
cord-277355-si3g5dih	52	8	or	or	CC
cord-277355-si3g5dih	52	9	pseudorevertants	pseudorevertant	NNS
cord-277355-si3g5dih	52	10	displayed	display	VBD
cord-277355-si3g5dih	52	11	attenuated	attenuated	JJ
cord-277355-si3g5dih	52	12	viral	viral	JJ
cord-277355-si3g5dih	52	13	growth	growth	NN
cord-277355-si3g5dih	52	14	kinetics	kinetic	NNS
cord-277355-si3g5dih	52	15	in	in	IN
cord-277355-si3g5dih	52	16	cell	cell	NN
cord-277355-si3g5dih	52	17	culture	culture	NN
cord-277355-si3g5dih	52	18	compared	compare	VBN
cord-277355-si3g5dih	52	19	with	with	IN
cord-277355-si3g5dih	52	20	those	those	DT
cord-277355-si3g5dih	52	21	of	of	IN
cord-277355-si3g5dih	52	22	the	the	DT
cord-277355-si3g5dih	52	23	wild	wild	JJ
cord-277355-si3g5dih	52	24	type	type	NN
cord-277355-si3g5dih	52	25	,	,	,
cord-277355-si3g5dih	52	26	without	without	IN
cord-277355-si3g5dih	52	27	influences	influence	NNS
cord-277355-si3g5dih	52	28	on	on	IN
cord-277355-si3g5dih	52	29	RNA	RNA	NNP
cord-277355-si3g5dih	52	30	replication	replication	NN
cord-277355-si3g5dih	52	31	and	and	CC
cord-277355-si3g5dih	52	32	translation	translation	NN
cord-277355-si3g5dih	52	33	,	,	,
cord-277355-si3g5dih	52	34	but	but	CC
cord-277355-si3g5dih	52	35	producing	produce	VBG
cord-277355-si3g5dih	52	36	substantial	substantial	JJ
cord-277355-si3g5dih	52	37	amounts	amount	NNS
cord-277355-si3g5dih	52	38	of	of	IN
cord-277355-si3g5dih	52	39	SVPs	svp	NNS
cord-277355-si3g5dih	52	40	[	[	-LRB-
cord-277355-si3g5dih	52	41	9	9	CD
cord-277355-si3g5dih	52	42	,	,	,
cord-277355-si3g5dih	52	43	20	20	CD
cord-277355-si3g5dih	52	44	,	,	,
cord-277355-si3g5dih	52	45	22	22	CD
cord-277355-si3g5dih	52	46	,	,	,
cord-277355-si3g5dih	52	47	23	23	CD
cord-277355-si3g5dih	52	48	]	]	-RRB-
cord-277355-si3g5dih	52	49	.	.	.
cord-277355-si3g5dih	53	1	Post	post	JJ
cord-277355-si3g5dih	53	2	-	-	JJ
cord-277355-si3g5dih	53	3	translation	translation	NN
cord-277355-si3g5dih	53	4	,	,	,
cord-277355-si3g5dih	53	5	CP	CP	NNP
cord-277355-si3g5dih	53	6	anchors	anchor	NNS
cord-277355-si3g5dih	53	7	in	in	IN
cord-277355-si3g5dih	53	8	the	the	DT
cord-277355-si3g5dih	53	9	ER	ER	NNP
cord-277355-si3g5dih	53	10	membrane	membrane	NN
cord-277355-si3g5dih	53	11	via	via	IN
cord-277355-si3g5dih	53	12	an	an	DT
cord-277355-si3g5dih	53	13	internal	internal	JJ
cord-277355-si3g5dih	53	14	signal	signal	NN
cord-277355-si3g5dih	53	15	peptide	peptide	NN
cord-277355-si3g5dih	53	16	sequence	sequence	NN
cord-277355-si3g5dih	53	17	(	(	-LRB-
cord-277355-si3g5dih	53	18	known	know	VBN
cord-277355-si3g5dih	53	19	as	as	IN
cord-277355-si3g5dih	53	20	the	the	DT
cord-277355-si3g5dih	53	21	anchor	anchor	NN
cord-277355-si3g5dih	53	22	)	)	-RRB-
cord-277355-si3g5dih	53	23	at	at	IN
cord-277355-si3g5dih	53	24	its	-PRON-	PRP$
cord-277355-si3g5dih	53	25	C	c	NN
cord-277355-si3g5dih	53	26	-	-	HYPH
cord-277355-si3g5dih	53	27	terminus	terminus	NN
cord-277355-si3g5dih	53	28	.	.	.
cord-277355-si3g5dih	54	1	The	the	DT
cord-277355-si3g5dih	54	2	anchor	anchor	NN
cord-277355-si3g5dih	54	3	spans	span	VBZ
cord-277355-si3g5dih	54	4	the	the	DT
cord-277355-si3g5dih	54	5	ER	ER	NNP
cord-277355-si3g5dih	54	6	membrane	membrane	NN
cord-277355-si3g5dih	54	7	and	and	CC
cord-277355-si3g5dih	54	8	directs	direct	VBZ
cord-277355-si3g5dih	54	9	the	the	DT
cord-277355-si3g5dih	54	10	translocation	translocation	NN
cord-277355-si3g5dih	54	11	of	of	IN
cord-277355-si3g5dih	54	12	the	the	DT
cord-277355-si3g5dih	54	13	downstream	downstream	JJ
cord-277355-si3g5dih	54	14	prM	prm	JJ
cord-277355-si3g5dih	54	15	protein	protein	NN
cord-277355-si3g5dih	54	16	.	.	.
cord-277355-si3g5dih	55	1	Cleavage	cleavage	NN
cord-277355-si3g5dih	55	2	of	of	IN
cord-277355-si3g5dih	55	3	the	the	DT
cord-277355-si3g5dih	55	4	C	C	NNP
cord-277355-si3g5dih	55	5	-	-	HYPH
cord-277355-si3g5dih	55	6	prM	prm	JJ
cord-277355-si3g5dih	55	7	junction	junction	NN
cord-277355-si3g5dih	55	8	employs	employ	VBZ
cord-277355-si3g5dih	55	9	a	a	DT
cord-277355-si3g5dih	55	10	coordinated	coordinated	JJ
cord-277355-si3g5dih	55	11	two	two	CD
cord-277355-si3g5dih	55	12	-	-	HYPH
cord-277355-si3g5dih	55	13	step	step	NN
cord-277355-si3g5dih	55	14	proteolytic	proteolytic	JJ
cord-277355-si3g5dih	55	15	process	process	NN
cord-277355-si3g5dih	55	16	by	by	IN
cord-277355-si3g5dih	55	17	viral	viral	JJ
cord-277355-si3g5dih	55	18	NS2B3	ns2b3	NN
cord-277355-si3g5dih	55	19	and	and	CC
cord-277355-si3g5dih	55	20	signalase	signalase	NN
cord-277355-si3g5dih	55	21	at	at	IN
cord-277355-si3g5dih	55	22	the	the	DT
cord-277355-si3g5dih	55	23	two	two	CD
cord-277355-si3g5dih	55	24	termini	terminus	NNS
cord-277355-si3g5dih	55	25	of	of	IN
cord-277355-si3g5dih	55	26	the	the	DT
cord-277355-si3g5dih	55	27	anchor	anchor	NN
cord-277355-si3g5dih	55	28	,	,	,
cord-277355-si3g5dih	55	29	and	and	CC
cord-277355-si3g5dih	55	30	the	the	DT
cord-277355-si3g5dih	55	31	signalase	signalase	NN
cord-277355-si3g5dih	55	32	cleavage	cleavage	NN
cord-277355-si3g5dih	55	33	of	of	IN
cord-277355-si3g5dih	55	34	prM	prm	NN
cord-277355-si3g5dih	55	35	in	in	IN
cord-277355-si3g5dih	55	36	the	the	DT
cord-277355-si3g5dih	55	37	lumen	lumen	NN
cord-277355-si3g5dih	55	38	remains	remain	VBZ
cord-277355-si3g5dih	55	39	inefficient	inefficient	JJ
cord-277355-si3g5dih	55	40	until	until	IN
cord-277355-si3g5dih	55	41	NS2B3	ns2b3	NN
cord-277355-si3g5dih	55	42	cleavage	cleavage	NN
cord-277355-si3g5dih	55	43	occurs	occur	VBZ
cord-277355-si3g5dih	56	1	[	[	-LRB-
cord-277355-si3g5dih	56	2	24	24	CD
cord-277355-si3g5dih	56	3	]	]	-RRB-
cord-277355-si3g5dih	56	4	[	[	-LRB-
cord-277355-si3g5dih	56	5	25	25	CD
cord-277355-si3g5dih	56	6	]	]	-RRB-
cord-277355-si3g5dih	56	7	[	[	-LRB-
cord-277355-si3g5dih	56	8	26	26	CD
cord-277355-si3g5dih	56	9	]	]	-RRB-
cord-277355-si3g5dih	56	10	[	[	-LRB-
cord-277355-si3g5dih	56	11	27	27	CD
cord-277355-si3g5dih	56	12	]	]	-RRB-
cord-277355-si3g5dih	56	13	[	[	-LRB-
cord-277355-si3g5dih	56	14	28	28	CD
cord-277355-si3g5dih	56	15	]	]	-RRB-
cord-277355-si3g5dih	56	16	[	[	-LRB-
cord-277355-si3g5dih	56	17	29	29	CD
cord-277355-si3g5dih	56	18	]	]	-RRB-
cord-277355-si3g5dih	56	19	.	.	.
cord-277355-si3g5dih	57	1	The	the	DT
cord-277355-si3g5dih	57	2	lack	lack	NN
cord-277355-si3g5dih	57	3	of	of	IN
cord-277355-si3g5dih	57	4	polar	polar	JJ
cord-277355-si3g5dih	57	5	residues	residue	NNS
cord-277355-si3g5dih	57	6	in	in	IN
cord-277355-si3g5dih	57	7	the	the	DT
cord-277355-si3g5dih	57	8	c	c	NN
cord-277355-si3g5dih	57	9	-	-	HYPH
cord-277355-si3g5dih	57	10	region	region	NN
cord-277355-si3g5dih	57	11	of	of	IN
cord-277355-si3g5dih	57	12	the	the	DT
cord-277355-si3g5dih	57	13	anchor	anchor	NN
cord-277355-si3g5dih	57	14	sequence	sequence	NN
cord-277355-si3g5dih	57	15	indicates	indicate	VBZ
cord-277355-si3g5dih	57	16	that	that	IN
cord-277355-si3g5dih	57	17	it	-PRON-	PRP
cord-277355-si3g5dih	57	18	is	be	VBZ
cord-277355-si3g5dih	57	19	not	not	RB
cord-277355-si3g5dih	57	20	a	a	DT
cord-277355-si3g5dih	57	21	typical	typical	JJ
cord-277355-si3g5dih	57	22	signal	signal	NN
cord-277355-si3g5dih	57	23	sequence	sequence	NN
cord-277355-si3g5dih	57	24	,	,	,
cord-277355-si3g5dih	57	25	and	and	CC
cord-277355-si3g5dih	57	26	a	a	DT
cord-277355-si3g5dih	57	27	PQAQA	PQAQA	NNP
cord-277355-si3g5dih	57	28	mutant	mutant	NN
cord-277355-si3g5dih	57	29	of	of	IN
cord-277355-si3g5dih	57	30	the	the	DT
cord-277355-si3g5dih	57	31	c	c	NN
cord-277355-si3g5dih	57	32	-	-	HYPH
cord-277355-si3g5dih	57	33	region	region	NN
cord-277355-si3g5dih	57	34	with	with	IN
cord-277355-si3g5dih	57	35	polar	polar	JJ
cord-277355-si3g5dih	57	36	residues	residue	NNS
cord-277355-si3g5dih	57	37	dramatically	dramatically	RB
cord-277355-si3g5dih	57	38	uncoupled	uncouple	VBD
cord-277355-si3g5dih	57	39	the	the	DT
cord-277355-si3g5dih	57	40	coordinated	coordinated	JJ
cord-277355-si3g5dih	57	41	proteolytic	proteolytic	JJ
cord-277355-si3g5dih	57	42	process	process	NN
cord-277355-si3g5dih	57	43	[	[	-LRB-
cord-277355-si3g5dih	57	44	25	25	CD
cord-277355-si3g5dih	57	45	]	]	-RRB-
cord-277355-si3g5dih	57	46	.	.	.
cord-277355-si3g5dih	58	1	However	however	RB
cord-277355-si3g5dih	58	2	,	,	,
cord-277355-si3g5dih	58	3	the	the	DT
cord-277355-si3g5dih	58	4	PQAQA	PQAQA	NNP
cord-277355-si3g5dih	58	5	mutant	mutant	NN
cord-277355-si3g5dih	58	6	displayed	display	VBD
cord-277355-si3g5dih	58	7	impaired	impaired	JJ
cord-277355-si3g5dih	58	8	growth	growth	NN
cord-277355-si3g5dih	58	9	kinetics	kinetic	NNS
cord-277355-si3g5dih	58	10	because	because	IN
cord-277355-si3g5dih	58	11	enhanced	enhanced	JJ
cord-277355-si3g5dih	58	12	signalase	signalase	NN
cord-277355-si3g5dih	58	13	cleavage	cleavage	NN
cord-277355-si3g5dih	58	14	of	of	IN
cord-277355-si3g5dih	58	15	anchor	anchor	JJ
cord-277355-si3g5dih	58	16	-	-	HYPH
cord-277355-si3g5dih	58	17	prM	prm	JJ
cord-277355-si3g5dih	58	18	increased	increase	VBD
cord-277355-si3g5dih	58	19	the	the	DT
cord-277355-si3g5dih	58	20	assembly	assembly	NN
cord-277355-si3g5dih	58	21	and	and	CC
cord-277355-si3g5dih	58	22	release	release	NN
cord-277355-si3g5dih	58	23	of	of	IN
cord-277355-si3g5dih	58	24	SVPs	svp	NNS
cord-277355-si3g5dih	58	25	at	at	IN
cord-277355-si3g5dih	58	26	the	the	DT
cord-277355-si3g5dih	58	27	expense	expense	NN
cord-277355-si3g5dih	58	28	of	of	IN
cord-277355-si3g5dih	58	29	infectious	infectious	JJ
cord-277355-si3g5dih	58	30	virion	virion	NN
cord-277355-si3g5dih	58	31	production	production	NN
cord-277355-si3g5dih	58	32	[	[	-LRB-
cord-277355-si3g5dih	58	33	28	28	CD
cord-277355-si3g5dih	58	34	,	,	,
cord-277355-si3g5dih	58	35	29	29	CD
cord-277355-si3g5dih	58	36	]	]	-RRB-
cord-277355-si3g5dih	58	37	;	;	:
cord-277355-si3g5dih	58	38	for	for	IN
cord-277355-si3g5dih	58	39	YFV	YFV	NNP
cord-277355-si3g5dih	58	40	,	,	,
cord-277355-si3g5dih	58	41	the	the	DT
cord-277355-si3g5dih	58	42	PQAQA	PQAQA	NNP
cord-277355-si3g5dih	58	43	mutant	mutant	NN
cord-277355-si3g5dih	58	44	is	be	VBZ
cord-277355-si3g5dih	58	45	even	even	RB
cord-277355-si3g5dih	58	46	lethal	lethal	JJ
cord-277355-si3g5dih	58	47	for	for	IN
cord-277355-si3g5dih	58	48	viral	viral	JJ
cord-277355-si3g5dih	58	49	production	production	NN
cord-277355-si3g5dih	58	50	[	[	-LRB-
cord-277355-si3g5dih	58	51	27	27	CD
cord-277355-si3g5dih	58	52	]	]	-RRB-
cord-277355-si3g5dih	58	53	.	.	.
cord-277355-si3g5dih	59	1	This	this	DT
cord-277355-si3g5dih	59	2	finding	finding	NN
cord-277355-si3g5dih	59	3	indicates	indicate	VBZ
cord-277355-si3g5dih	59	4	that	that	IN
cord-277355-si3g5dih	59	5	sequential	sequential	JJ
cord-277355-si3g5dih	59	6	cleavage	cleavage	NN
cord-277355-si3g5dih	59	7	at	at	IN
cord-277355-si3g5dih	59	8	the	the	DT
cord-277355-si3g5dih	59	9	C	C	NNP
cord-277355-si3g5dih	59	10	-	-	HYPH
cord-277355-si3g5dih	59	11	prM	prm	JJ
cord-277355-si3g5dih	59	12	junction	junction	NN
cord-277355-si3g5dih	59	13	facilitates	facilitate	VBZ
cord-277355-si3g5dih	59	14	infectious	infectious	JJ
cord-277355-si3g5dih	59	15	particle	particle	NN
cord-277355-si3g5dih	59	16	assembly	assembly	NN
cord-277355-si3g5dih	59	17	.	.	.
cord-277355-si3g5dih	60	1	In	in	IN
cord-277355-si3g5dih	60	2	addition	addition	NN
cord-277355-si3g5dih	60	3	,	,	,
cord-277355-si3g5dih	60	4	the	the	DT
cord-277355-si3g5dih	60	5	anchor	anchor	NN
cord-277355-si3g5dih	60	6	also	also	RB
cord-277355-si3g5dih	60	7	contributes	contribute	VBZ
cord-277355-si3g5dih	60	8	to	to	IN
cord-277355-si3g5dih	60	9	E	e	NN
cord-277355-si3g5dih	60	10	protein	protein	NN
cord-277355-si3g5dih	60	11	stability	stability	NN
cord-277355-si3g5dih	60	12	to	to	TO
cord-277355-si3g5dih	60	13	prompt	prompt	VB
cord-277355-si3g5dih	60	14	assembly	assembly	NN
cord-277355-si3g5dih	60	15	of	of	IN
cord-277355-si3g5dih	60	16	infectious	infectious	JJ
cord-277355-si3g5dih	60	17	particles	particle	NNS
cord-277355-si3g5dih	60	18	[	[	-LRB-
cord-277355-si3g5dih	60	19	30	30	CD
cord-277355-si3g5dih	60	20	]	]	-RRB-
cord-277355-si3g5dih	60	21	,	,	,
cord-277355-si3g5dih	60	22	and	and	CC
cord-277355-si3g5dih	60	23	a	a	DT
cord-277355-si3g5dih	60	24	cleavable	cleavable	JJ
cord-277355-si3g5dih	60	25	anchor	anchor	NN
cord-277355-si3g5dih	60	26	in	in	IN
cord-277355-si3g5dih	60	27	context	context	NN
cord-277355-si3g5dih	60	28	is	be	VBZ
cord-277355-si3g5dih	60	29	more	more	RBR
cord-277355-si3g5dih	60	30	efficient	efficient	JJ
cord-277355-si3g5dih	60	31	than	than	IN
cord-277355-si3g5dih	60	32	separate	separate	JJ
cord-277355-si3g5dih	60	33	mature	mature	JJ
cord-277355-si3g5dih	60	34	CP	cp	NN
cord-277355-si3g5dih	60	35	for	for	IN
cord-277355-si3g5dih	60	36	particle	particle	NN
cord-277355-si3g5dih	60	37	assembly	assembly	NN
cord-277355-si3g5dih	60	38	[	[	-LRB-
cord-277355-si3g5dih	60	39	29	29	CD
cord-277355-si3g5dih	60	40	,	,	,
cord-277355-si3g5dih	60	41	31	31	CD
cord-277355-si3g5dih	60	42	]	]	-RRB-
cord-277355-si3g5dih	60	43	.	.	.
cord-277355-si3g5dih	61	1	Interestingly	interestingly	RB
cord-277355-si3g5dih	61	2	,	,	,
cord-277355-si3g5dih	61	3	a	a	DT
cord-277355-si3g5dih	61	4	noncleavable	noncleavable	JJ
cord-277355-si3g5dih	61	5	C	c	NN
cord-277355-si3g5dih	61	6	-	-	HYPH
cord-277355-si3g5dih	61	7	anchor	anchor	NN
cord-277355-si3g5dih	61	8	could	could	MD
cord-277355-si3g5dih	61	9	not	not	RB
cord-277355-si3g5dih	61	10	be	be	VB
cord-277355-si3g5dih	61	11	utilized	utilize	VBN
cord-277355-si3g5dih	61	12	for	for	IN
cord-277355-si3g5dih	61	13	packaging	package	VBG
cord-277355-si3g5dih	61	14	the	the	DT
cord-277355-si3g5dih	61	15	MVEV	MVEV	NNS
cord-277355-si3g5dih	61	16	replicon	replicon	NN
cord-277355-si3g5dih	61	17	,	,	,
cord-277355-si3g5dih	61	18	but	but	CC
cord-277355-si3g5dih	61	19	that	that	DT
cord-277355-si3g5dih	61	20	of	of	IN
cord-277355-si3g5dih	61	21	YFV	YFV	NNP
cord-277355-si3g5dih	61	22	and	and	CC
cord-277355-si3g5dih	61	23	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	61	24	could	could	MD
cord-277355-si3g5dih	61	25	,	,	,
cord-277355-si3g5dih	61	26	suggesting	suggest	VBG
cord-277355-si3g5dih	61	27	that	that	IN
cord-277355-si3g5dih	61	28	the	the	DT
cord-277355-si3g5dih	61	29	accessibility	accessibility	NN
cord-277355-si3g5dih	61	30	of	of	IN
cord-277355-si3g5dih	61	31	the	the	DT
cord-277355-si3g5dih	61	32	anchor	anchor	NN
cord-277355-si3g5dih	61	33	cleavage	cleavage	NN
cord-277355-si3g5dih	61	34	site	site	NN
cord-277355-si3g5dih	61	35	to	to	IN
cord-277355-si3g5dih	61	36	the	the	DT
cord-277355-si3g5dih	61	37	NS2B3	NS2B3	NNP
cord-277355-si3g5dih	61	38	protease	protease	NN
cord-277355-si3g5dih	61	39	is	be	VBZ
cord-277355-si3g5dih	61	40	virus	virus	NN
cord-277355-si3g5dih	61	41	specific	specific	JJ
cord-277355-si3g5dih	61	42	[	[	-LRB-
cord-277355-si3g5dih	61	43	29	29	CD
cord-277355-si3g5dih	61	44	,	,	,
cord-277355-si3g5dih	61	45	32	32	CD
cord-277355-si3g5dih	61	46	,	,	,
cord-277355-si3g5dih	61	47	33	33	CD
cord-277355-si3g5dih	61	48	]	]	-RRB-
cord-277355-si3g5dih	61	49	.	.	.
cord-277355-si3g5dih	62	1	Only	only	RB
cord-277355-si3g5dih	62	2	mature	mature	JJ
cord-277355-si3g5dih	62	3	CPs	cp	NNS
cord-277355-si3g5dih	62	4	are	be	VBP
cord-277355-si3g5dih	62	5	packaged	package	VBN
cord-277355-si3g5dih	62	6	into	into	IN
cord-277355-si3g5dih	62	7	virions	virion	NNS
cord-277355-si3g5dih	62	8	in	in	IN
cord-277355-si3g5dih	62	9	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	62	10	infection	infection	NN
cord-277355-si3g5dih	62	11	;	;	:
cord-277355-si3g5dih	62	12	surprisingly	surprisingly	RB
cord-277355-si3g5dih	62	13	,	,	,
cord-277355-si3g5dih	62	14	a	a	DT
cord-277355-si3g5dih	62	15	recent	recent	JJ
cord-277355-si3g5dih	62	16	study	study	NN
cord-277355-si3g5dih	62	17	reported	report	VBD
cord-277355-si3g5dih	62	18	that	that	IN
cord-277355-si3g5dih	62	19	unprocessed	unprocessed	JJ
cord-277355-si3g5dih	62	20	C	c	NN
cord-277355-si3g5dih	62	21	-	-	HYPH
cord-277355-si3g5dih	62	22	anchor	anchor	NN
cord-277355-si3g5dih	62	23	proteins	protein	NNS
cord-277355-si3g5dih	62	24	could	could	MD
cord-277355-si3g5dih	62	25	be	be	VB
cord-277355-si3g5dih	62	26	packaged	package	VBN
cord-277355-si3g5dih	62	27	into	into	IN
cord-277355-si3g5dih	62	28	DENV2	denv2	NN
cord-277355-si3g5dih	62	29	pseudoviruses	pseudoviruse	NNS
cord-277355-si3g5dih	62	30	[	[	-LRB-
cord-277355-si3g5dih	62	31	34	34	CD
cord-277355-si3g5dih	62	32	]	]	-RRB-
cord-277355-si3g5dih	62	33	.	.	.
cord-277355-si3g5dih	63	1	In	in	IN
cord-277355-si3g5dih	63	2	summary	summary	NN
cord-277355-si3g5dih	63	3	,	,	,
cord-277355-si3g5dih	63	4	the	the	DT
cord-277355-si3g5dih	63	5	sequential	sequential	JJ
cord-277355-si3g5dih	63	6	cleavage	cleavage	NN
cord-277355-si3g5dih	63	7	of	of	IN
cord-277355-si3g5dih	63	8	the	the	DT
cord-277355-si3g5dih	63	9	C	C	NNP
cord-277355-si3g5dih	63	10	-	-	HYPH
cord-277355-si3g5dih	63	11	prM	prm	JJ
cord-277355-si3g5dih	63	12	junction	junction	NN
cord-277355-si3g5dih	63	13	is	be	VBZ
cord-277355-si3g5dih	63	14	pivotal	pivotal	JJ
cord-277355-si3g5dih	63	15	for	for	IN
cord-277355-si3g5dih	63	16	efficient	efficient	JJ
cord-277355-si3g5dih	63	17	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	63	18	assembly	assembly	NN
cord-277355-si3g5dih	63	19	,	,	,
cord-277355-si3g5dih	63	20	and	and	CC
cord-277355-si3g5dih	63	21	this	this	DT
cord-277355-si3g5dih	63	22	process	process	NN
cord-277355-si3g5dih	63	23	is	be	VBZ
cord-277355-si3g5dih	63	24	controlled	control	VBN
cord-277355-si3g5dih	63	25	by	by	IN
cord-277355-si3g5dih	63	26	sequence	sequence	NN
cord-277355-si3g5dih	63	27	elements	element	NNS
cord-277355-si3g5dih	63	28	in	in	IN
cord-277355-si3g5dih	63	29	the	the	DT
cord-277355-si3g5dih	63	30	CP	cp	NN
cord-277355-si3g5dih	63	31	anchor	anchor	NN
cord-277355-si3g5dih	63	32	.	.	.
cord-277355-si3g5dih	64	1	Flavivirus	Flavivirus	NNP
cord-277355-si3g5dih	64	2	CP	CP	NNP
cord-277355-si3g5dih	64	3	is	be	VBZ
cord-277355-si3g5dih	64	4	involved	involve	VBN
cord-277355-si3g5dih	64	5	in	in	IN
cord-277355-si3g5dih	64	6	vRNA	vrna	JJ
cord-277355-si3g5dih	64	7	replication	replication	NN
cord-277355-si3g5dih	64	8	in	in	IN
cord-277355-si3g5dih	64	9	a	a	DT
cord-277355-si3g5dih	64	10	special	special	JJ
cord-277355-si3g5dih	64	11	manner	manner	NN
cord-277355-si3g5dih	64	12	.	.	.
cord-277355-si3g5dih	65	1	Although	although	IN
cord-277355-si3g5dih	65	2	RNA	RNA	NNP
cord-277355-si3g5dih	65	3	sequences	sequence	NNS
cord-277355-si3g5dih	65	4	are	be	VBP
cord-277355-si3g5dih	65	5	not	not	RB
cord-277355-si3g5dih	65	6	conserved	conserve	VBN
cord-277355-si3g5dih	65	7	among	among	IN
cord-277355-si3g5dih	65	8	divergent	divergent	JJ
cord-277355-si3g5dih	65	9	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	65	10	,	,	,
cord-277355-si3g5dih	65	11	there	there	EX
cord-277355-si3g5dih	65	12	are	be	VBP
cord-277355-si3g5dih	65	13	several	several	JJ
cord-277355-si3g5dih	65	14	conserved	conserve	VBN
cord-277355-si3g5dih	65	15	RNA	RNA	NNP
cord-277355-si3g5dih	65	16	secondary	secondary	JJ
cord-277355-si3g5dih	65	17	structures	structure	NNS
cord-277355-si3g5dih	65	18	in	in	IN
cord-277355-si3g5dih	65	19	the	the	DT
cord-277355-si3g5dih	65	20	5	5	CD
cord-277355-si3g5dih	65	21	0	0	CD
cord-277355-si3g5dih	65	22	-terminus	-terminus	:
cord-277355-si3g5dih	65	23	of	of	IN
cord-277355-si3g5dih	65	24	the	the	DT
cord-277355-si3g5dih	65	25	CP	cp	NN
cord-277355-si3g5dih	65	26	-	-	HYPH
cord-277355-si3g5dih	65	27	encoding	encoding	NN
cord-277355-si3g5dih	65	28	sequence	sequence	NN
cord-277355-si3g5dih	65	29	that	that	WDT
cord-277355-si3g5dih	65	30	are	be	VBP
cord-277355-si3g5dih	65	31	necessary	necessary	JJ
cord-277355-si3g5dih	65	32	for	for	IN
cord-277355-si3g5dih	65	33	vRNA	vrna	JJ
cord-277355-si3g5dih	65	34	replication	replication	NN
cord-277355-si3g5dih	65	35	.	.	.
cord-277355-si3g5dih	66	1	(	(	-LRB-
cord-277355-si3g5dih	66	2	1	1	CD
cord-277355-si3g5dih	66	3	)	)	-RRB-
cord-277355-si3g5dih	67	1	The	the	DT
cord-277355-si3g5dih	67	2	AUG	AUG	NNP
cord-277355-si3g5dih	67	3	codon	codon	NN
cord-277355-si3g5dih	67	4	of	of	IN
cord-277355-si3g5dih	67	5	CP	cp	NN
cord-277355-si3g5dih	67	6	starts	start	NNS
cord-277355-si3g5dih	67	7	from	from	IN
cord-277355-si3g5dih	67	8	the	the	DT
cord-277355-si3g5dih	67	9	stem	stem	NN
cord-277355-si3g5dih	67	10	loop	loop	NN
cord-277355-si3g5dih	67	11	B	b	NN
cord-277355-si3g5dih	67	12	(	(	-LRB-
cord-277355-si3g5dih	67	13	SLB	SLB	NNP
cord-277355-si3g5dih	67	14	)	)	-RRB-
cord-277355-si3g5dih	67	15	structure	structure	NN
cord-277355-si3g5dih	67	16	,	,	,
cord-277355-si3g5dih	67	17	and	and	CC
cord-277355-si3g5dih	67	18	a	a	DT
cord-277355-si3g5dih	67	19	partial	partial	JJ
cord-277355-si3g5dih	67	20	5	5	CD
cord-277355-si3g5dih	67	21	0	0	CD
cord-277355-si3g5dih	67	22	-upstream	-upstream	NN
cord-277355-si3g5dih	67	23	AUG	AUG	NNP
cord-277355-si3g5dih	67	24	region	region	NN
cord-277355-si3g5dih	67	25	(	(	-LRB-
cord-277355-si3g5dih	67	26	UAR)-flanking	uar)-flanke	VBG
cord-277355-si3g5dih	67	27	stem	stem	NN
cord-277355-si3g5dih	67	28	(	(	-LRB-
cord-277355-si3g5dih	67	29	UFS	UFS	NNP
cord-277355-si3g5dih	67	30	)	)	-RRB-
cord-277355-si3g5dih	67	31	is	be	VBZ
cord-277355-si3g5dih	67	32	located	locate	VBN
cord-277355-si3g5dih	67	33	in	in	IN
cord-277355-si3g5dih	67	34	the	the	DT
cord-277355-si3g5dih	67	35	CP	cp	NN
cord-277355-si3g5dih	67	36	coding	coding	NN
cord-277355-si3g5dih	67	37	sequence	sequence	NN
cord-277355-si3g5dih	67	38	[	[	-LRB-
cord-277355-si3g5dih	67	39	35	35	CD
cord-277355-si3g5dih	67	40	]	]	-RRB-
cord-277355-si3g5dih	67	41	.	.	.
cord-277355-si3g5dih	68	1	(	(	-LRB-
cord-277355-si3g5dih	68	2	2	2	LS
cord-277355-si3g5dih	68	3	)	)	-RRB-
cord-277355-si3g5dih	69	1	The	the	DT
cord-277355-si3g5dih	69	2	5	5	CD
cord-277355-si3g5dih	69	3	0	0	CD
cord-277355-si3g5dih	69	4	downstream	downstream	JJ
cord-277355-si3g5dih	69	5	AUG	AUG	NNP
cord-277355-si3g5dih	69	6	region	region	NN
cord-277355-si3g5dih	69	7	(	(	-LRB-
cord-277355-si3g5dih	69	8	5	5	CD
cord-277355-si3g5dih	69	9	0	0	CD
cord-277355-si3g5dih	69	10	DAR	DAR	NNP
cord-277355-si3g5dih	69	11	)	)	-RRB-
cord-277355-si3g5dih	69	12	and	and	CC
cord-277355-si3g5dih	69	13	(	(	-LRB-
cord-277355-si3g5dih	69	14	3	3	CD
cord-277355-si3g5dih	69	15	)	)	-RRB-
cord-277355-si3g5dih	69	16	5	5	CD
cord-277355-si3g5dih	69	17	0	0	CD
cord-277355-si3g5dih	69	18	cyclization	cyclization	NN
cord-277355-si3g5dih	69	19	sequence	sequence	NN
cord-277355-si3g5dih	69	20	(	(	-LRB-
cord-277355-si3g5dih	69	21	5	5	CD
cord-277355-si3g5dih	69	22	0	0	CD
cord-277355-si3g5dih	69	23	CS	CS	NNP
cord-277355-si3g5dih	69	24	)	)	-RRB-
cord-277355-si3g5dih	69	25	[	[	-LRB-
cord-277355-si3g5dih	69	26	36	36	CD
cord-277355-si3g5dih	69	27	]	]	-RRB-
cord-277355-si3g5dih	69	28	[	[	-LRB-
cord-277355-si3g5dih	69	29	37	37	CD
cord-277355-si3g5dih	69	30	]	]	-RRB-
cord-277355-si3g5dih	69	31	[	[	-LRB-
cord-277355-si3g5dih	69	32	38	38	CD
cord-277355-si3g5dih	69	33	]	]	-RRB-
cord-277355-si3g5dih	69	34	.	.	.
cord-277355-si3g5dih	70	1	(	(	-LRB-
cord-277355-si3g5dih	70	2	4	4	LS
cord-277355-si3g5dih	70	3	)	)	-RRB-
cord-277355-si3g5dih	71	1	A	a	DT
cord-277355-si3g5dih	71	2	stable	stable	JJ
cord-277355-si3g5dih	71	3	hairpin	hairpin	NN
cord-277355-si3g5dih	71	4	known	know	VBN
cord-277355-si3g5dih	71	5	as	as	IN
cord-277355-si3g5dih	71	6	capsidcoding	capsidcode	VBG
cord-277355-si3g5dih	71	7	hairpin	hairpin	NNP
cord-277355-si3g5dih	71	8	(	(	-LRB-
cord-277355-si3g5dih	71	9	cHP	cHP	NNP
cord-277355-si3g5dih	71	10	)	)	-RRB-
cord-277355-si3g5dih	71	11	is	be	VBZ
cord-277355-si3g5dih	71	12	surrounded	surround	VBN
cord-277355-si3g5dih	71	13	by	by	IN
cord-277355-si3g5dih	71	14	the	the	DT
cord-277355-si3g5dih	71	15	5	5	CD
cord-277355-si3g5dih	71	16	0	0	CD
cord-277355-si3g5dih	71	17	DAR	DAR	NNP
cord-277355-si3g5dih	71	18	and	and	CC
cord-277355-si3g5dih	71	19	3	3	CD
cord-277355-si3g5dih	71	20	0	0	CD
cord-277355-si3g5dih	71	21	CS	CS	NNP
cord-277355-si3g5dih	71	22	[	[	-LRB-
cord-277355-si3g5dih	71	23	39	39	CD
cord-277355-si3g5dih	71	24	,	,	,
cord-277355-si3g5dih	71	25	40	40	CD
cord-277355-si3g5dih	71	26	]	]	-RRB-
cord-277355-si3g5dih	71	27	.	.	.
cord-277355-si3g5dih	72	1	(	(	-LRB-
cord-277355-si3g5dih	72	2	5	5	LS
cord-277355-si3g5dih	72	3	)	)	-RRB-
cord-277355-si3g5dih	73	1	The	the	DT
cord-277355-si3g5dih	73	2	downstream	downstream	JJ
cord-277355-si3g5dih	73	3	5	5	CD
cord-277355-si3g5dih	73	4	0	0	CD
cord-277355-si3g5dih	73	5	CS	CS	NNP
cord-277355-si3g5dih	73	6	pseudoknot	pseudoknot	NNP
cord-277355-si3g5dih	73	7	(	(	-LRB-
cord-277355-si3g5dih	73	8	DCS	DCS	NNP
cord-277355-si3g5dih	73	9	-	-	HYPH
cord-277355-si3g5dih	73	10	PK	PK	NNP
cord-277355-si3g5dih	73	11	)	)	-RRB-
cord-277355-si3g5dih	73	12	element	element	NN
cord-277355-si3g5dih	73	13	contains	contain	VBZ
cord-277355-si3g5dih	73	14	sequences	sequence	NNS
cord-277355-si3g5dih	73	15	complementary	complementary	JJ
cord-277355-si3g5dih	73	16	to	to	IN
cord-277355-si3g5dih	73	17	a	a	DT
cord-277355-si3g5dih	73	18	region	region	NN
cord-277355-si3g5dih	73	19	in	in	IN
cord-277355-si3g5dih	73	20	the	the	DT
cord-277355-si3g5dih	73	21	3	3	CD
cord-277355-si3g5dih	73	22	0	0	CD
cord-277355-si3g5dih	73	23	UTR	UTR	NNP
cord-277355-si3g5dih	73	24	[	[	-LRB-
cord-277355-si3g5dih	73	25	41	41	CD
cord-277355-si3g5dih	73	26	]	]	-RRB-
cord-277355-si3g5dih	73	27	[	[	-LRB-
cord-277355-si3g5dih	73	28	42	42	CD
cord-277355-si3g5dih	73	29	]	]	-RRB-
cord-277355-si3g5dih	73	30	[	[	-LRB-
cord-277355-si3g5dih	73	31	43	43	CD
cord-277355-si3g5dih	73	32	]	]	-RRB-
cord-277355-si3g5dih	73	33	.	.	.
cord-277355-si3g5dih	74	1	Therefore	therefore	RB
cord-277355-si3g5dih	74	2	,	,	,
cord-277355-si3g5dih	74	3	these	these	DT
cord-277355-si3g5dih	74	4	cis	ci	NNS
cord-277355-si3g5dih	74	5	-	-	HYPH
cord-277355-si3g5dih	74	6	elements	element	NNS
cord-277355-si3g5dih	74	7	must	must	MD
cord-277355-si3g5dih	74	8	be	be	VB
cord-277355-si3g5dih	74	9	taken	take	VBN
cord-277355-si3g5dih	74	10	into	into	IN
cord-277355-si3g5dih	74	11	consideration	consideration	NN
cord-277355-si3g5dih	74	12	when	when	WRB
cord-277355-si3g5dih	74	13	studying	study	VBG
cord-277355-si3g5dih	74	14	CP	cp	NN
cord-277355-si3g5dih	74	15	functions	function	NNS
cord-277355-si3g5dih	74	16	or	or	CC
cord-277355-si3g5dih	74	17	constructing	construct	VBG
cord-277355-si3g5dih	74	18	subgenomic	subgenomic	JJ
cord-277355-si3g5dih	74	19	replicon	replicon	NN
cord-277355-si3g5dih	74	20	tools	tool	NNS
cord-277355-si3g5dih	74	21	and	and	CC
cord-277355-si3g5dih	74	22	inserting	insert	VBG
cord-277355-si3g5dih	74	23	markers	marker	NNS
cord-277355-si3g5dih	74	24	between	between	IN
cord-277355-si3g5dih	74	25	the	the	DT
cord-277355-si3g5dih	74	26	viral	viral	JJ
cord-277355-si3g5dih	74	27	5	5	CD
cord-277355-si3g5dih	74	28	0	0	CD
cord-277355-si3g5dih	74	29	UTR	UTR	NNP
cord-277355-si3g5dih	74	30	and	and	CC
cord-277355-si3g5dih	74	31	CP	cp	NN
cord-277355-si3g5dih	74	32	coding	coding	NN
cord-277355-si3g5dih	74	33	sequence	sequence	NN
cord-277355-si3g5dih	74	34	.	.	.
cord-277355-si3g5dih	75	1	Although	although	IN
cord-277355-si3g5dih	75	2	current	current	JJ
cord-277355-si3g5dih	75	3	studies	study	NNS
cord-277355-si3g5dih	75	4	on	on	IN
cord-277355-si3g5dih	75	5	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	75	6	have	have	VBP
cord-277355-si3g5dih	75	7	shown	show	VBN
cord-277355-si3g5dih	75	8	that	that	IN
cord-277355-si3g5dih	75	9	the	the	DT
cord-277355-si3g5dih	75	10	flaviviral	flaviviral	NNP
cord-277355-si3g5dih	75	11	assembly	assembly	NN
cord-277355-si3g5dih	75	12	process	process	NN
cord-277355-si3g5dih	75	13	does	do	VBZ
cord-277355-si3g5dih	75	14	not	not	RB
cord-277355-si3g5dih	75	15	exhibit	exhibit	VB
cord-277355-si3g5dih	75	16	a	a	DT
cord-277355-si3g5dih	75	17	necessary	necessary	JJ
cord-277355-si3g5dih	75	18	step	step	NN
cord-277355-si3g5dih	75	19	occurring	occur	VBG
cord-277355-si3g5dih	75	20	in	in	IN
cord-277355-si3g5dih	75	21	the	the	DT
cord-277355-si3g5dih	75	22	cell	cell	NN
cord-277355-si3g5dih	75	23	nucleus	nucleus	NN
cord-277355-si3g5dih	75	24	,	,	,
cord-277355-si3g5dih	75	25	it	-PRON-	PRP
cord-277355-si3g5dih	75	26	has	have	VBZ
cord-277355-si3g5dih	75	27	been	be	VBN
cord-277355-si3g5dih	75	28	well	well	RB
cord-277355-si3g5dih	75	29	demonstrated	demonstrate	VBN
cord-277355-si3g5dih	75	30	that	that	IN
cord-277355-si3g5dih	75	31	many	many	JJ
cord-277355-si3g5dih	75	32	mosquito	mosquito	NN
cord-277355-si3g5dih	75	33	-	-	HYPH
cord-277355-si3g5dih	75	34	borne	bear	VBN
cord-277355-si3g5dih	75	35	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	75	36	CPs	cp	NNS
cord-277355-si3g5dih	75	37	partially	partially	RB
cord-277355-si3g5dih	75	38	localize	localize	VBP
cord-277355-si3g5dih	75	39	in	in	IN
cord-277355-si3g5dih	75	40	the	the	DT
cord-277355-si3g5dih	75	41	cell	cell	NN
cord-277355-si3g5dih	75	42	nucleus	nucleus	NN
cord-277355-si3g5dih	75	43	[	[	-LRB-
cord-277355-si3g5dih	75	44	44	44	CD
cord-277355-si3g5dih	75	45	]	]	-RRB-
cord-277355-si3g5dih	75	46	[	[	-LRB-
cord-277355-si3g5dih	75	47	45	45	CD
cord-277355-si3g5dih	75	48	]	]	-RRB-
cord-277355-si3g5dih	76	1	[	[	-LRB-
cord-277355-si3g5dih	76	2	46	46	CD
cord-277355-si3g5dih	76	3	]	]	-RRB-
cord-277355-si3g5dih	77	1	[	[	-LRB-
cord-277355-si3g5dih	77	2	47	47	CD
cord-277355-si3g5dih	77	3	]	]	-RRB-
cord-277355-si3g5dih	78	1	[	[	-LRB-
cord-277355-si3g5dih	78	2	48	48	CD
cord-277355-si3g5dih	78	3	]	]	-RRB-
cord-277355-si3g5dih	78	4	;	;	:
cord-277355-si3g5dih	78	5	in	in	IN
cord-277355-si3g5dih	78	6	the	the	DT
cord-277355-si3g5dih	78	7	cytoplasm	cytoplasm	NN
cord-277355-si3g5dih	78	8	,	,	,
cord-277355-si3g5dih	78	9	in	in	IN
cord-277355-si3g5dih	78	10	addition	addition	NN
cord-277355-si3g5dih	78	11	to	to	IN
cord-277355-si3g5dih	78	12	localizing	localize	VBG
cord-277355-si3g5dih	78	13	in	in	IN
cord-277355-si3g5dih	78	14	the	the	DT
cord-277355-si3g5dih	78	15	ER	er	NN
cord-277355-si3g5dih	78	16	,	,	,
cord-277355-si3g5dih	78	17	DENV	DENV	NNP
cord-277355-si3g5dih	78	18	CP	CP	NNP
cord-277355-si3g5dih	78	19	and	and	CC
cord-277355-si3g5dih	78	20	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	78	21	CP	CP	NNP
cord-277355-si3g5dih	78	22	have	have	VBP
cord-277355-si3g5dih	78	23	also	also	RB
cord-277355-si3g5dih	78	24	been	be	VBN
cord-277355-si3g5dih	78	25	demonstrated	demonstrate	VBN
cord-277355-si3g5dih	78	26	to	to	TO
cord-277355-si3g5dih	78	27	accumulate	accumulate	VB
cord-277355-si3g5dih	78	28	on	on	IN
cord-277355-si3g5dih	78	29	LDs	LDs	NNP
cord-277355-si3g5dih	78	30	[	[	-LRB-
cord-277355-si3g5dih	78	31	13	13	CD
cord-277355-si3g5dih	78	32	,	,	,
cord-277355-si3g5dih	78	33	16	16	CD
cord-277355-si3g5dih	78	34	]	]	-RRB-
cord-277355-si3g5dih	78	35	,	,	,
cord-277355-si3g5dih	78	36	but	but	CC
cord-277355-si3g5dih	78	37	the	the	DT
cord-277355-si3g5dih	78	38	link	link	NN
cord-277355-si3g5dih	78	39	between	between	IN
cord-277355-si3g5dih	78	40	the	the	DT
cord-277355-si3g5dih	78	41	functional	functional	JJ
cord-277355-si3g5dih	78	42	importance	importance	NN
cord-277355-si3g5dih	78	43	and	and	CC
cord-277355-si3g5dih	78	44	the	the	DT
cord-277355-si3g5dih	78	45	subcellular	subcellular	JJ
cord-277355-si3g5dih	78	46	distribution	distribution	NN
cord-277355-si3g5dih	78	47	of	of	IN
cord-277355-si3g5dih	78	48	CPs	cp	NNS
cord-277355-si3g5dih	78	49	is	be	VBZ
cord-277355-si3g5dih	78	50	still	still	RB
cord-277355-si3g5dih	78	51	unclear	unclear	JJ
cord-277355-si3g5dih	78	52	.	.	.
cord-277355-si3g5dih	79	1	Flavivirus	Flavivirus	NNP
cord-277355-si3g5dih	79	2	CPs	cp	NNS
cord-277355-si3g5dih	79	3	localized	localize	VBN
cord-277355-si3g5dih	79	4	in	in	IN
cord-277355-si3g5dih	79	5	the	the	DT
cord-277355-si3g5dih	79	6	nucleus	nucleus	NN
cord-277355-si3g5dih	79	7	independent	independent	NN
cord-277355-si3g5dih	79	8	of	of	IN
cord-277355-si3g5dih	79	9	viral	viral	JJ
cord-277355-si3g5dih	79	10	infection	infection	NN
cord-277355-si3g5dih	79	11	,	,	,
cord-277355-si3g5dih	79	12	and	and	CC
cord-277355-si3g5dih	79	13	overexpression	overexpression	NN
cord-277355-si3g5dih	79	14	of	of	IN
cord-277355-si3g5dih	79	15	only	only	RB
cord-277355-si3g5dih	79	16	the	the	DT
cord-277355-si3g5dih	79	17	capsid	capsid	NN
cord-277355-si3g5dih	79	18	gene	gene	NN
cord-277355-si3g5dih	79	19	resulted	result	VBD
cord-277355-si3g5dih	79	20	in	in	IN
cord-277355-si3g5dih	79	21	its	-PRON-	PRP$
cord-277355-si3g5dih	79	22	nuclear	nuclear	JJ
cord-277355-si3g5dih	79	23	localization	localization	NN
cord-277355-si3g5dih	79	24	and	and	CC
cord-277355-si3g5dih	79	25	colocalization	colocalization	NN
cord-277355-si3g5dih	79	26	with	with	IN
cord-277355-si3g5dih	79	27	nucleoli	nucleoli	NNP
cord-277355-si3g5dih	79	28	[	[	-LRB-
cord-277355-si3g5dih	79	29	45	45	CD
cord-277355-si3g5dih	79	30	,	,	,
cord-277355-si3g5dih	79	31	49	49	CD
cord-277355-si3g5dih	79	32	]	]	-RRB-
cord-277355-si3g5dih	79	33	.	.	.
cord-277355-si3g5dih	80	1	Although	although	IN
cord-277355-si3g5dih	80	2	the	the	DT
cord-277355-si3g5dih	80	3	molecular	molecular	JJ
cord-277355-si3g5dih	80	4	weight	weight	NN
cord-277355-si3g5dih	80	5	of	of	IN
cord-277355-si3g5dih	80	6	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	80	7	CPs	CPs	NNP
cord-277355-si3g5dih	80	8	is	be	VBZ
cord-277355-si3g5dih	80	9	relatively	relatively	RB
cord-277355-si3g5dih	80	10	low	low	JJ
cord-277355-si3g5dih	80	11	,	,	,
cord-277355-si3g5dih	80	12	they	-PRON-	PRP
cord-277355-si3g5dih	80	13	are	be	VBP
cord-277355-si3g5dih	80	14	actively	actively	RB
cord-277355-si3g5dih	80	15	transported	transport	VBN
cord-277355-si3g5dih	80	16	into	into	IN
cord-277355-si3g5dih	80	17	the	the	DT
cord-277355-si3g5dih	80	18	nucleus	nucleus	NN
cord-277355-si3g5dih	80	19	but	but	CC
cord-277355-si3g5dih	80	20	not	not	RB
cord-277355-si3g5dih	80	21	by	by	IN
cord-277355-si3g5dih	80	22	simple	simple	JJ
cord-277355-si3g5dih	80	23	diffusion	diffusion	NN
cord-277355-si3g5dih	80	24	[	[	-LRB-
cord-277355-si3g5dih	80	25	44	44	CD
cord-277355-si3g5dih	80	26	,	,	,
cord-277355-si3g5dih	80	27	46	46	CD
cord-277355-si3g5dih	80	28	]	]	-RRB-
cord-277355-si3g5dih	80	29	.	.	.
cord-277355-si3g5dih	81	1	Interestingly	interestingly	RB
cord-277355-si3g5dih	81	2	,	,	,
cord-277355-si3g5dih	81	3	the	the	DT
cord-277355-si3g5dih	81	4	nuclear	nuclear	JJ
cord-277355-si3g5dih	81	5	localization	localization	NN
cord-277355-si3g5dih	81	6	signals	signal	NNS
cord-277355-si3g5dih	81	7	(	(	-LRB-
cord-277355-si3g5dih	81	8	NLSs	NLSs	NNP
cord-277355-si3g5dih	81	9	)	)	-RRB-
cord-277355-si3g5dih	81	10	of	of	IN
cord-277355-si3g5dih	81	11	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	81	12	CPs	CPs	NNP
cord-277355-si3g5dih	81	13	are	be	VBP
cord-277355-si3g5dih	81	14	heterogeneous	heterogeneous	JJ
cord-277355-si3g5dih	81	15	[	[	-LRB-
cord-277355-si3g5dih	81	16	44	44	CD
cord-277355-si3g5dih	81	17	]	]	-RRB-
cord-277355-si3g5dih	81	18	[	[	-LRB-
cord-277355-si3g5dih	81	19	45	45	CD
cord-277355-si3g5dih	81	20	]	]	-RRB-
cord-277355-si3g5dih	82	1	[	[	-LRB-
cord-277355-si3g5dih	82	2	46	46	CD
cord-277355-si3g5dih	82	3	]	]	-RRB-
cord-277355-si3g5dih	83	1	[	[	-LRB-
cord-277355-si3g5dih	83	2	49	49	CD
cord-277355-si3g5dih	83	3	]	]	-RRB-
cord-277355-si3g5dih	83	4	[	[	-LRB-
cord-277355-si3g5dih	83	5	50	50	CD
cord-277355-si3g5dih	83	6	]	]	-RRB-
cord-277355-si3g5dih	83	7	[	[	-LRB-
cord-277355-si3g5dih	83	8	51	51	CD
cord-277355-si3g5dih	83	9	]	]	-RRB-
cord-277355-si3g5dih	83	10	.	.	.
cord-277355-si3g5dih	84	1	It	-PRON-	PRP
cord-277355-si3g5dih	84	2	has	have	VBZ
cord-277355-si3g5dih	84	3	also	also	RB
cord-277355-si3g5dih	84	4	been	be	VBN
cord-277355-si3g5dih	84	5	demonstrated	demonstrate	VBN
cord-277355-si3g5dih	84	6	that	that	IN
cord-277355-si3g5dih	84	7	the	the	DT
cord-277355-si3g5dih	84	8	nuclear	nuclear	JJ
cord-277355-si3g5dih	84	9	localization	localization	NN
cord-277355-si3g5dih	84	10	of	of	IN
cord-277355-si3g5dih	84	11	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	84	12	CPs	CPs	NNP
cord-277355-si3g5dih	84	13	is	be	VBZ
cord-277355-si3g5dih	84	14	functionally	functionally	RB
cord-277355-si3g5dih	84	15	correlated	correlate	VBN
cord-277355-si3g5dih	84	16	with	with	IN
cord-277355-si3g5dih	84	17	virus	virus	NN
cord-277355-si3g5dih	84	18	production	production	NN
cord-277355-si3g5dih	84	19	[	[	-LRB-
cord-277355-si3g5dih	84	20	45	45	CD
cord-277355-si3g5dih	84	21	,	,	,
cord-277355-si3g5dih	84	22	49	49	CD
cord-277355-si3g5dih	84	23	,	,	,
cord-277355-si3g5dih	84	24	51	51	CD
cord-277355-si3g5dih	84	25	]	]	-RRB-
cord-277355-si3g5dih	84	26	.	.	.
cord-277355-si3g5dih	85	1	It	-PRON-	PRP
cord-277355-si3g5dih	85	2	is	be	VBZ
cord-277355-si3g5dih	85	3	worth	worth	JJ
cord-277355-si3g5dih	85	4	stressing	stress	VBG
cord-277355-si3g5dih	85	5	that	that	IN
cord-277355-si3g5dih	85	6	the	the	DT
cord-277355-si3g5dih	85	7	key	key	JJ
cord-277355-si3g5dih	85	8	sites	site	NNS
cord-277355-si3g5dih	85	9	of	of	IN
cord-277355-si3g5dih	85	10	the	the	DT
cord-277355-si3g5dih	85	11	predicted	predict	VBN
cord-277355-si3g5dih	85	12	NLS	NLS	NNP
cord-277355-si3g5dih	85	13	are	be	VBP
cord-277355-si3g5dih	85	14	usually	usually	RB
cord-277355-si3g5dih	85	15	basic	basic	JJ
cord-277355-si3g5dih	85	16	residues	residue	NNS
cord-277355-si3g5dih	85	17	,	,	,
cord-277355-si3g5dih	85	18	which	which	WDT
cord-277355-si3g5dih	85	19	play	play	VBP
cord-277355-si3g5dih	85	20	a	a	DT
cord-277355-si3g5dih	85	21	role	role	NN
cord-277355-si3g5dih	85	22	in	in	IN
cord-277355-si3g5dih	85	23	RNA	RNA	NNP
cord-277355-si3g5dih	85	24	binding	bind	VBG
cord-277355-si3g5dih	85	25	for	for	IN
cord-277355-si3g5dih	85	26	CPs	cp	NNS
cord-277355-si3g5dih	85	27	.	.	.
cord-277355-si3g5dih	86	1	However	however	RB
cord-277355-si3g5dih	86	2	,	,	,
cord-277355-si3g5dih	86	3	it	-PRON-	PRP
cord-277355-si3g5dih	86	4	is	be	VBZ
cord-277355-si3g5dih	86	5	still	still	RB
cord-277355-si3g5dih	86	6	to	to	TO
cord-277355-si3g5dih	86	7	be	be	VB
cord-277355-si3g5dih	86	8	solved	solve	VBN
cord-277355-si3g5dih	86	9	to	to	TO
cord-277355-si3g5dih	86	10	uncouple	uncouple	VB
cord-277355-si3g5dih	86	11	the	the	DT
cord-277355-si3g5dih	86	12	correlation	correlation	NN
cord-277355-si3g5dih	86	13	of	of	IN
cord-277355-si3g5dih	86	14	nucleolar	nucleolar	JJ
cord-277355-si3g5dih	86	15	localization	localization	NN
cord-277355-si3g5dih	86	16	and	and	CC
cord-277355-si3g5dih	86	17	RNA	RNA	NNP
cord-277355-si3g5dih	86	18	association	association	NN
cord-277355-si3g5dih	86	19	in	in	IN
cord-277355-si3g5dih	86	20	present	present	JJ
cord-277355-si3g5dih	86	21	studies	study	NNS
cord-277355-si3g5dih	86	22	.	.	.
cord-277355-si3g5dih	87	1	Both	both	DT
cord-277355-si3g5dih	87	2	the	the	DT
cord-277355-si3g5dih	87	3	DENV	DENV	NNP
cord-277355-si3g5dih	87	4	and	and	CC
cord-277355-si3g5dih	87	5	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	87	6	CPs	CPs	NNPS
cord-277355-si3g5dih	87	7	were	be	VBD
cord-277355-si3g5dih	87	8	observed	observe	VBN
cord-277355-si3g5dih	87	9	accumulating	accumulate	VBG
cord-277355-si3g5dih	87	10	on	on	IN
cord-277355-si3g5dih	87	11	the	the	DT
cord-277355-si3g5dih	87	12	surface	surface	NN
cord-277355-si3g5dih	87	13	of	of	IN
cord-277355-si3g5dih	87	14	LDs	LDs	NNP
cord-277355-si3g5dih	87	15	in	in	IN
cord-277355-si3g5dih	87	16	infected	infected	JJ
cord-277355-si3g5dih	87	17	cells	cell	NNS
cord-277355-si3g5dih	87	18	[	[	-LRB-
cord-277355-si3g5dih	87	19	13	13	CD
cord-277355-si3g5dih	87	20	,	,	,
cord-277355-si3g5dih	87	21	16	16	CD
cord-277355-si3g5dih	87	22	]	]	-RRB-
cord-277355-si3g5dih	87	23	.	.	.
cord-277355-si3g5dih	88	1	It	-PRON-	PRP
cord-277355-si3g5dih	88	2	can	can	MD
cord-277355-si3g5dih	88	3	be	be	VB
cord-277355-si3g5dih	88	4	speculated	speculate	VBN
cord-277355-si3g5dih	88	5	that	that	IN
cord-277355-si3g5dih	88	6	the	the	DT
cord-277355-si3g5dih	88	7	CP	cp	NN
cord-277355-si3g5dih	88	8	accumulation	accumulation	NN
cord-277355-si3g5dih	88	9	on	on	IN
cord-277355-si3g5dih	88	10	LDs	LDs	NNP
cord-277355-si3g5dih	88	11	may	may	MD
cord-277355-si3g5dih	88	12	be	be	VB
cord-277355-si3g5dih	88	13	a	a	DT
cord-277355-si3g5dih	88	14	common	common	JJ
cord-277355-si3g5dih	88	15	feature	feature	NN
cord-277355-si3g5dih	88	16	in	in	IN
cord-277355-si3g5dih	88	17	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	88	18	infection	infection	NN
cord-277355-si3g5dih	88	19	,	,	,
cord-277355-si3g5dih	88	20	but	but	CC
cord-277355-si3g5dih	88	21	further	further	JJ
cord-277355-si3g5dih	88	22	verification	verification	NN
cord-277355-si3g5dih	88	23	is	be	VBZ
cord-277355-si3g5dih	88	24	needed	need	VBN
cord-277355-si3g5dih	88	25	.	.	.
cord-277355-si3g5dih	89	1	Experimental	experimental	JJ
cord-277355-si3g5dih	89	2	evidence	evidence	NN
cord-277355-si3g5dih	89	3	indicated	indicate	VBD
cord-277355-si3g5dih	89	4	that	that	IN
cord-277355-si3g5dih	89	5	the	the	DT
cord-277355-si3g5dih	89	6	hydrophobic	hydrophobic	JJ
cord-277355-si3g5dih	89	7	a2-helix	a2-helix	NNS
cord-277355-si3g5dih	89	8	and	and	CC
cord-277355-si3g5dih	89	9	the	the	DT
cord-277355-si3g5dih	89	10	positively	positively	RB
cord-277355-si3g5dih	89	11	charged	charge	VBN
cord-277355-si3g5dih	89	12	N	n	CD
cord-277355-si3g5dih	89	13	-	-	HYPH
cord-277355-si3g5dih	89	14	terminal	terminal	NN
cord-277355-si3g5dih	89	15	region	region	NN
cord-277355-si3g5dih	89	16	participate	participate	VBP
cord-277355-si3g5dih	89	17	in	in	IN
cord-277355-si3g5dih	89	18	the	the	DT
cord-277355-si3g5dih	89	19	interaction	interaction	NN
cord-277355-si3g5dih	89	20	with	with	IN
cord-277355-si3g5dih	89	21	LDs	LDs	NNP
cord-277355-si3g5dih	89	22	[	[	-LRB-
cord-277355-si3g5dih	89	23	46	46	CD
cord-277355-si3g5dih	89	24	,	,	,
cord-277355-si3g5dih	89	25	52	52	CD
cord-277355-si3g5dih	89	26	]	]	-RRB-
cord-277355-si3g5dih	89	27	,	,	,
cord-277355-si3g5dih	89	28	but	but	CC
cord-277355-si3g5dih	89	29	these	these	DT
cord-277355-si3g5dih	89	30	regions	region	NNS
cord-277355-si3g5dih	89	31	are	be	VBP
cord-277355-si3g5dih	89	32	also	also	RB
cord-277355-si3g5dih	89	33	responsible	responsible	JJ
cord-277355-si3g5dih	89	34	for	for	IN
cord-277355-si3g5dih	89	35	ER	ER	NNP
cord-277355-si3g5dih	89	36	membrane	membrane	NNP
cord-277355-si3g5dih	89	37	association	association	NNP
cord-277355-si3g5dih	89	38	and	and	CC
cord-277355-si3g5dih	89	39	RNA	RNA	NNP
cord-277355-si3g5dih	89	40	binding	binding	NN
cord-277355-si3g5dih	89	41	,	,	,
cord-277355-si3g5dih	89	42	respectively	respectively	RB
cord-277355-si3g5dih	89	43	.	.	.
cord-277355-si3g5dih	90	1	Thus	thus	RB
cord-277355-si3g5dih	90	2	,	,	,
cord-277355-si3g5dih	90	3	studies	study	NNS
cord-277355-si3g5dih	90	4	to	to	TO
cord-277355-si3g5dih	90	5	define	define	VB
cord-277355-si3g5dih	90	6	the	the	DT
cord-277355-si3g5dih	90	7	significance	significance	NN
cord-277355-si3g5dih	90	8	of	of	IN
cord-277355-si3g5dih	90	9	LD	LD	NNP
cord-277355-si3g5dih	90	10	-	-	HYPH
cord-277355-si3g5dih	90	11	associated	associate	VBN
cord-277355-si3g5dih	90	12	CPs	cp	NNS
cord-277355-si3g5dih	90	13	during	during	IN
cord-277355-si3g5dih	90	14	viral	viral	JJ
cord-277355-si3g5dih	90	15	infection	infection	NN
cord-277355-si3g5dih	90	16	are	be	VBP
cord-277355-si3g5dih	90	17	complicated	complicated	JJ
cord-277355-si3g5dih	90	18	,	,	,
cord-277355-si3g5dih	90	19	although	although	IN
cord-277355-si3g5dih	90	20	the	the	DT
cord-277355-si3g5dih	90	21	numbers	number	NNS
cord-277355-si3g5dih	90	22	of	of	IN
cord-277355-si3g5dih	90	23	LDs	LDs	NNP
cord-277355-si3g5dih	90	24	and	and	CC
cord-277355-si3g5dih	90	25	viral	viral	JJ
cord-277355-si3g5dih	90	26	replication	replication	NN
cord-277355-si3g5dih	90	27	affect	affect	VBP
cord-277355-si3g5dih	90	28	each	each	DT
cord-277355-si3g5dih	90	29	other	other	JJ
cord-277355-si3g5dih	90	30	[	[	-LRB-
cord-277355-si3g5dih	90	31	16	16	CD
cord-277355-si3g5dih	90	32	]	]	-RRB-
cord-277355-si3g5dih	90	33	.	.	.
cord-277355-si3g5dih	91	1	It	-PRON-	PRP
cord-277355-si3g5dih	91	2	is	be	VBZ
cord-277355-si3g5dih	91	3	possible	possible	JJ
cord-277355-si3g5dih	91	4	that	that	IN
cord-277355-si3g5dih	91	5	LDs	LDs	NNP
cord-277355-si3g5dih	91	6	may	may	MD
cord-277355-si3g5dih	91	7	serve	serve	VB
cord-277355-si3g5dih	91	8	as	as	IN
cord-277355-si3g5dih	91	9	a	a	DT
cord-277355-si3g5dih	91	10	reservoir	reservoir	NN
cord-277355-si3g5dih	91	11	of	of	IN
cord-277355-si3g5dih	91	12	CPs	cp	NNS
cord-277355-si3g5dih	91	13	in	in	IN
cord-277355-si3g5dih	91	14	early	early	JJ
cord-277355-si3g5dih	91	15	infection	infection	NN
cord-277355-si3g5dih	91	16	and	and	CC
cord-277355-si3g5dih	91	17	are	be	VBP
cord-277355-si3g5dih	91	18	then	then	RB
cord-277355-si3g5dih	91	19	mobilized	mobilize	VBN
cord-277355-si3g5dih	91	20	to	to	IN
cord-277355-si3g5dih	91	21	the	the	DT
cord-277355-si3g5dih	91	22	ER	ER	NNP
cord-277355-si3g5dih	91	23	membrane	membrane	NN
cord-277355-si3g5dih	91	24	for	for	IN
cord-277355-si3g5dih	91	25	particle	particle	NN
cord-277355-si3g5dih	91	26	morphogenesis	morphogenesis	NN
cord-277355-si3g5dih	91	27	when	when	WRB
cord-277355-si3g5dih	91	28	needed	need	VBN
cord-277355-si3g5dih	91	29	[	[	-LRB-
cord-277355-si3g5dih	91	30	16	16	CD
cord-277355-si3g5dih	91	31	]	]	-RRB-
cord-277355-si3g5dih	91	32	.	.	.
cord-277355-si3g5dih	92	1	However	however	RB
cord-277355-si3g5dih	92	2	,	,	,
cord-277355-si3g5dih	92	3	the	the	DT
cord-277355-si3g5dih	92	4	functional	functional	JJ
cord-277355-si3g5dih	92	5	significance	significance	NN
cord-277355-si3g5dih	92	6	of	of	IN
cord-277355-si3g5dih	92	7	CP	cp	NN
cord-277355-si3g5dih	92	8	accumulation	accumulation	NN
cord-277355-si3g5dih	92	9	on	on	IN
cord-277355-si3g5dih	92	10	LDs	LDs	NNP
cord-277355-si3g5dih	92	11	still	still	RB
cord-277355-si3g5dih	92	12	deserves	deserve	VBZ
cord-277355-si3g5dih	92	13	further	further	JJ
cord-277355-si3g5dih	92	14	study	study	NN
cord-277355-si3g5dih	92	15	.	.	.
cord-277355-si3g5dih	93	1	One	one	CD
cord-277355-si3g5dih	93	2	of	of	IN
cord-277355-si3g5dih	93	3	the	the	DT
cord-277355-si3g5dih	93	4	most	most	RBS
cord-277355-si3g5dih	93	5	important	important	JJ
cord-277355-si3g5dih	93	6	roles	role	NNS
cord-277355-si3g5dih	93	7	of	of	IN
cord-277355-si3g5dih	93	8	CPs	cp	NNS
cord-277355-si3g5dih	93	9	in	in	IN
cord-277355-si3g5dih	93	10	the	the	DT
cord-277355-si3g5dih	93	11	viral	viral	JJ
cord-277355-si3g5dih	93	12	lifecycle	lifecycle	NN
cord-277355-si3g5dih	93	13	is	be	VBZ
cord-277355-si3g5dih	93	14	the	the	DT
cord-277355-si3g5dih	93	15	formation	formation	NN
cord-277355-si3g5dih	93	16	of	of	IN
cord-277355-si3g5dih	93	17	the	the	DT
cord-277355-si3g5dih	93	18	NC	NC	NNP
cord-277355-si3g5dih	93	19	,	,	,
cord-277355-si3g5dih	93	20	and	and	CC
cord-277355-si3g5dih	93	21	the	the	DT
cord-277355-si3g5dih	93	22	CP	cp	NN
cord-277355-si3g5dih	93	23	dimer	dimer	NN
cord-277355-si3g5dih	93	24	is	be	VBZ
cord-277355-si3g5dih	93	25	believed	believe	VBN
cord-277355-si3g5dih	93	26	to	to	TO
cord-277355-si3g5dih	93	27	be	be	VB
cord-277355-si3g5dih	93	28	the	the	DT
cord-277355-si3g5dih	93	29	building	building	NN
cord-277355-si3g5dih	93	30	block	block	NN
cord-277355-si3g5dih	93	31	for	for	IN
cord-277355-si3g5dih	93	32	NC	NC	NNP
cord-277355-si3g5dih	93	33	assembly	assembly	NN
cord-277355-si3g5dih	93	34	[	[	-LRB-
cord-277355-si3g5dih	93	35	53	53	CD
cord-277355-si3g5dih	93	36	]	]	-RRB-
cord-277355-si3g5dih	93	37	.	.	.
cord-277355-si3g5dih	94	1	Previously	previously	RB
cord-277355-si3g5dih	94	2	resolved	resolve	VBN
cord-277355-si3g5dih	94	3	cryo	cryo	NN
cord-277355-si3g5dih	94	4	-	-	HYPH
cord-277355-si3g5dih	94	5	EM	EM	NNP
cord-277355-si3g5dih	94	6	structures	structure	NNS
cord-277355-si3g5dih	94	7	of	of	IN
cord-277355-si3g5dih	94	8	both	both	CC
cord-277355-si3g5dih	94	9	mature	mature	JJ
cord-277355-si3g5dih	94	10	and	and	CC
cord-277355-si3g5dih	94	11	immature	immature	JJ
cord-277355-si3g5dih	94	12	DENV	DENV	NNP
cord-277355-si3g5dih	94	13	virions	virion	NNS
cord-277355-si3g5dih	94	14	revealed	reveal	VBD
cord-277355-si3g5dih	94	15	that	that	IN
cord-277355-si3g5dih	94	16	the	the	DT
cord-277355-si3g5dih	94	17	core	core	NN
cord-277355-si3g5dih	94	18	lacks	lack	VBZ
cord-277355-si3g5dih	94	19	a	a	DT
cord-277355-si3g5dih	94	20	well	well	RB
cord-277355-si3g5dih	94	21	-	-	HYPH
cord-277355-si3g5dih	94	22	formed	form	VBN
cord-277355-si3g5dih	94	23	protein	protein	NN
cord-277355-si3g5dih	94	24	organization	organization	NN
cord-277355-si3g5dih	94	25	[	[	-LRB-
cord-277355-si3g5dih	94	26	2	2	CD
cord-277355-si3g5dih	94	27	,	,	,
cord-277355-si3g5dih	94	28	54	54	CD
cord-277355-si3g5dih	94	29	]	]	-RRB-
cord-277355-si3g5dih	94	30	.	.	.
cord-277355-si3g5dih	95	1	According	accord	VBG
cord-277355-si3g5dih	95	2	to	to	IN
cord-277355-si3g5dih	95	3	a	a	DT
cord-277355-si3g5dih	95	4	recent	recent	JJ
cord-277355-si3g5dih	95	5	9-Å	9-å	CD
cord-277355-si3g5dih	95	6	-	-	HYPH
cord-277355-si3g5dih	95	7	resolution	resolution	NN
cord-277355-si3g5dih	95	8	structure	structure	NN
cord-277355-si3g5dih	95	9	of	of	IN
cord-277355-si3g5dih	95	10	immature	immature	JJ
cord-277355-si3g5dih	95	11	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	95	12	,	,	,
cord-277355-si3g5dih	95	13	the	the	DT
cord-277355-si3g5dih	95	14	NC	NC	NNP
cord-277355-si3g5dih	95	15	core	core	NN
cord-277355-si3g5dih	95	16	was	be	VBD
cord-277355-si3g5dih	95	17	observed	observe	VBN
cord-277355-si3g5dih	95	18	close	close	RB
cord-277355-si3g5dih	95	19	to	to	IN
cord-277355-si3g5dih	95	20	the	the	DT
cord-277355-si3g5dih	95	21	transmembrane	transmembrane	NN
cord-277355-si3g5dih	95	22	domains	domain	NNS
cord-277355-si3g5dih	95	23	of	of	IN
cord-277355-si3g5dih	95	24	the	the	DT
cord-277355-si3g5dih	95	25	E	e	NN
cord-277355-si3g5dih	95	26	and	and	CC
cord-277355-si3g5dih	95	27	prM	prm	JJ
cord-277355-si3g5dih	95	28	proteins	protein	NNS
cord-277355-si3g5dih	95	29	[	[	-LRB-
cord-277355-si3g5dih	95	30	55	55	CD
cord-277355-si3g5dih	95	31	]	]	-RRB-
cord-277355-si3g5dih	95	32	.	.	.
cord-277355-si3g5dih	96	1	The	the	DT
cord-277355-si3g5dih	96	2	NC	NC	NNP
cord-277355-si3g5dih	96	3	core	core	NN
cord-277355-si3g5dih	96	4	of	of	IN
cord-277355-si3g5dih	96	5	immature	immature	JJ
cord-277355-si3g5dih	96	6	Kunjin	Kunjin	NNP
cord-277355-si3g5dih	96	7	virus	virus	NN
cord-277355-si3g5dih	96	8	(	(	-LRB-
cord-277355-si3g5dih	96	9	KUNV	KUNV	NNP
cord-277355-si3g5dih	96	10	)	)	-RRB-
cord-277355-si3g5dih	96	11	was	be	VBD
cord-277355-si3g5dih	96	12	also	also	RB
cord-277355-si3g5dih	96	13	shown	show	VBN
cord-277355-si3g5dih	96	14	to	to	TO
cord-277355-si3g5dih	96	15	be	be	VB
cord-277355-si3g5dih	96	16	positioned	position	VBN
cord-277355-si3g5dih	96	17	asymmetrically	asymmetrically	RB
cord-277355-si3g5dih	96	18	with	with	IN
cord-277355-si3g5dih	96	19	respect	respect	NN
cord-277355-si3g5dih	96	20	to	to	IN
cord-277355-si3g5dih	96	21	the	the	DT
cord-277355-si3g5dih	96	22	glycoprotein	glycoprotein	NN
cord-277355-si3g5dih	96	23	shell	shell	NN
cord-277355-si3g5dih	96	24	[	[	-LRB-
cord-277355-si3g5dih	96	25	56	56	CD
cord-277355-si3g5dih	96	26	]	]	-RRB-
cord-277355-si3g5dih	96	27	.	.	.
cord-277355-si3g5dih	97	1	Therefore	therefore	RB
cord-277355-si3g5dih	97	2	,	,	,
cord-277355-si3g5dih	97	3	these	these	DT
cord-277355-si3g5dih	97	4	results	result	NNS
cord-277355-si3g5dih	97	5	indicate	indicate	VBP
cord-277355-si3g5dih	97	6	that	that	IN
cord-277355-si3g5dih	97	7	the	the	DT
cord-277355-si3g5dih	97	8	icosahedral	icosahedral	JJ
cord-277355-si3g5dih	97	9	axes	axis	NNS
cord-277355-si3g5dih	97	10	of	of	IN
cord-277355-si3g5dih	97	11	the	the	DT
cord-277355-si3g5dih	97	12	CP	cp	NN
cord-277355-si3g5dih	97	13	shell	shell	NN
cord-277355-si3g5dih	97	14	may	may	MD
cord-277355-si3g5dih	97	15	not	not	RB
cord-277355-si3g5dih	97	16	coincide	coincide	VB
cord-277355-si3g5dih	97	17	with	with	IN
cord-277355-si3g5dih	97	18	the	the	DT
cord-277355-si3g5dih	97	19	axes	axis	NNS
cord-277355-si3g5dih	97	20	of	of	IN
cord-277355-si3g5dih	97	21	the	the	DT
cord-277355-si3g5dih	97	22	dominant	dominant	JJ
cord-277355-si3g5dih	97	23	outer	outer	JJ
cord-277355-si3g5dih	97	24	glycoprotein	glycoprotein	NN
cord-277355-si3g5dih	97	25	shell	shell	NN
cord-277355-si3g5dih	97	26	,	,	,
cord-277355-si3g5dih	97	27	thus	thus	RB
cord-277355-si3g5dih	97	28	causing	cause	VBG
cord-277355-si3g5dih	97	29	poor	poor	JJ
cord-277355-si3g5dih	97	30	reconstruction	reconstruction	NN
cord-277355-si3g5dih	97	31	of	of	IN
cord-277355-si3g5dih	97	32	the	the	DT
cord-277355-si3g5dih	97	33	CP	cp	NN
cord-277355-si3g5dih	97	34	shell	shell	NN
cord-277355-si3g5dih	97	35	.	.	.
cord-277355-si3g5dih	98	1	To	to	TO
cord-277355-si3g5dih	98	2	assemble	assemble	VB
cord-277355-si3g5dih	98	3	the	the	DT
cord-277355-si3g5dih	98	4	NC	NC	NNP
cord-277355-si3g5dih	98	5	,	,	,
cord-277355-si3g5dih	98	6	CP	CP	NNP
cord-277355-si3g5dih	98	7	must	must	MD
cord-277355-si3g5dih	98	8	bind	bind	VB
cord-277355-si3g5dih	98	9	to	to	IN
cord-277355-si3g5dih	98	10	vRNA	vrna	NN
cord-277355-si3g5dih	98	11	.	.	.
cord-277355-si3g5dih	99	1	Based	base	VBN
cord-277355-si3g5dih	99	2	on	on	IN
cord-277355-si3g5dih	99	3	the	the	DT
cord-277355-si3g5dih	99	4	structures	structure	NNS
cord-277355-si3g5dih	99	5	of	of	IN
cord-277355-si3g5dih	99	6	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	99	7	CP	cp	NN
cord-277355-si3g5dih	99	8	dimers	dimer	NNS
cord-277355-si3g5dih	99	9	,	,	,
cord-277355-si3g5dih	99	10	the	the	DT
cord-277355-si3g5dih	99	11	positively	positively	RB
cord-277355-si3g5dih	99	12	charged	charge	VBN
cord-277355-si3g5dih	99	13	a4-a4	a4-a4	NNP
cord-277355-si3g5dih	99	14	0	0	CD
cord-277355-si3g5dih	99	15	interface	interface	NN
cord-277355-si3g5dih	99	16	is	be	VBZ
cord-277355-si3g5dih	99	17	proposed	propose	VBN
cord-277355-si3g5dih	99	18	as	as	IN
cord-277355-si3g5dih	99	19	the	the	DT
cord-277355-si3g5dih	99	20	main	main	JJ
cord-277355-si3g5dih	99	21	RNA	RNA	NNP
cord-277355-si3g5dih	99	22	binding	binding	NN
cord-277355-si3g5dih	99	23	site	site	NN
cord-277355-si3g5dih	99	24	[	[	-LRB-
cord-277355-si3g5dih	99	25	10	10	CD
cord-277355-si3g5dih	99	26	]	]	-RRB-
cord-277355-si3g5dih	99	27	.	.	.
cord-277355-si3g5dih	100	1	In	in	IN
cord-277355-si3g5dih	100	2	fact	fact	NN
cord-277355-si3g5dih	100	3	,	,	,
cord-277355-si3g5dih	100	4	in	in	IN
cord-277355-si3g5dih	100	5	vitro	vitro	FW
cord-277355-si3g5dih	100	6	studies	study	NNS
cord-277355-si3g5dih	100	7	have	have	VBP
cord-277355-si3g5dih	100	8	shown	show	VBN
cord-277355-si3g5dih	100	9	that	that	IN
cord-277355-si3g5dih	100	10	the	the	DT
cord-277355-si3g5dih	100	11	N	n	CD
cord-277355-si3g5dih	100	12	-	-	HYPH
cord-277355-si3g5dih	100	13	terminal	terminal	NN
cord-277355-si3g5dih	100	14	region	region	NN
cord-277355-si3g5dih	100	15	of	of	IN
cord-277355-si3g5dih	100	16	CP	CP	NNP
cord-277355-si3g5dih	100	17	also	also	RB
cord-277355-si3g5dih	100	18	binds	bind	VBZ
cord-277355-si3g5dih	100	19	to	to	IN
cord-277355-si3g5dih	100	20	RNA	RNA	NNP
cord-277355-si3g5dih	100	21	[	[	-LRB-
cord-277355-si3g5dih	100	22	15	15	CD
cord-277355-si3g5dih	100	23	,	,	,
cord-277355-si3g5dih	100	24	57	57	CD
cord-277355-si3g5dih	100	25	]	]	-RRB-
cord-277355-si3g5dih	100	26	,	,	,
cord-277355-si3g5dih	100	27	and	and	CC
cord-277355-si3g5dih	100	28	the	the	DT
cord-277355-si3g5dih	100	29	N	n	CD
cord-277355-si3g5dih	100	30	-	-	HYPH
cord-277355-si3g5dih	100	31	terminal	terminal	NN
cord-277355-si3g5dih	100	32	region	region	NN
cord-277355-si3g5dih	100	33	is	be	VBZ
cord-277355-si3g5dih	100	34	essential	essential	JJ
cord-277355-si3g5dih	100	35	for	for	IN
cord-277355-si3g5dih	100	36	viral	viral	JJ
cord-277355-si3g5dih	100	37	particle	particle	NN
cord-277355-si3g5dih	100	38	assembly	assembly	NN
cord-277355-si3g5dih	100	39	[	[	-LRB-
cord-277355-si3g5dih	100	40	58	58	CD
cord-277355-si3g5dih	100	41	]	]	-RRB-
cord-277355-si3g5dih	100	42	.	.	.
cord-277355-si3g5dih	101	1	The	the	DT
cord-277355-si3g5dih	101	2	CP	cp	NN
cord-277355-si3g5dih	101	3	dimers	dimer	NNS
cord-277355-si3g5dih	101	4	showed	show	VBD
cord-277355-si3g5dih	101	5	no	no	DT
cord-277355-si3g5dih	101	6	specificity	specificity	NN
cord-277355-si3g5dih	101	7	toward	toward	IN
cord-277355-si3g5dih	101	8	different	different	JJ
cord-277355-si3g5dih	101	9	nucleic	nucleic	JJ
cord-277355-si3g5dih	101	10	acids	acid	NNS
cord-277355-si3g5dih	101	11	in	in	IN
cord-277355-si3g5dih	101	12	vitro	vitro	FW
cord-277355-si3g5dih	101	13	[	[	-LRB-
cord-277355-si3g5dih	101	14	13	13	CD
cord-277355-si3g5dih	101	15	,	,	,
cord-277355-si3g5dih	101	16	17	17	CD
cord-277355-si3g5dih	101	17	]	]	-RRB-
cord-277355-si3g5dih	101	18	;	;	:
cord-277355-si3g5dih	101	19	however	however	RB
cord-277355-si3g5dih	101	20	,	,	,
cord-277355-si3g5dih	101	21	only	only	RB
cord-277355-si3g5dih	101	22	positive	positive	JJ
cord-277355-si3g5dih	101	23	-	-	HYPH
cord-277355-si3g5dih	101	24	sense	sense	NN
cord-277355-si3g5dih	101	25	vRNA	vrna	NN
cord-277355-si3g5dih	101	26	is	be	VBZ
cord-277355-si3g5dih	101	27	packaged	package	VBN
cord-277355-si3g5dih	101	28	in	in	IN
cord-277355-si3g5dih	101	29	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	101	30	virions	virion	NNS
cord-277355-si3g5dih	101	31	,	,	,
cord-277355-si3g5dih	101	32	and	and	CC
cord-277355-si3g5dih	101	33	a	a	DT
cord-277355-si3g5dih	101	34	study	study	NN
cord-277355-si3g5dih	101	35	in	in	IN
cord-277355-si3g5dih	101	36	vitro	vitro	FW
cord-277355-si3g5dih	101	37	showed	show	VBD
cord-277355-si3g5dih	101	38	that	that	IN
cord-277355-si3g5dih	101	39	the	the	DT
cord-277355-si3g5dih	101	40	DENV	DENV	NNP
cord-277355-si3g5dih	101	41	CPs	CPs	NNPS
cord-277355-si3g5dih	101	42	and	and	CC
cord-277355-si3g5dih	101	43	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	101	44	CPs	cp	NNS
cord-277355-si3g5dih	101	45	associate	associate	VBP
cord-277355-si3g5dih	101	46	with	with	IN
cord-277355-si3g5dih	101	47	vRNA	vrna	JJ
cord-277355-si3g5dih	101	48	at	at	IN
cord-277355-si3g5dih	101	49	specific	specific	JJ
cord-277355-si3g5dih	101	50	sites	site	NNS
cord-277355-si3g5dih	101	51	rather	rather	RB
cord-277355-si3g5dih	101	52	than	than	IN
cord-277355-si3g5dih	101	53	in	in	IN
cord-277355-si3g5dih	101	54	a	a	DT
cord-277355-si3g5dih	101	55	random	random	JJ
cord-277355-si3g5dih	101	56	manner	manner	NN
cord-277355-si3g5dih	101	57	[	[	-LRB-
cord-277355-si3g5dih	101	58	59	59	CD
cord-277355-si3g5dih	101	59	]	]	-RRB-
cord-277355-si3g5dih	101	60	.	.	.
cord-277355-si3g5dih	102	1	The	the	DT
cord-277355-si3g5dih	102	2	encapsidation	encapsidation	NN
cord-277355-si3g5dih	102	3	signals	signal	VBZ
cord-277355-si3g5dih	102	4	for	for	IN
cord-277355-si3g5dih	102	5	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	102	6	genomes	genome	NNS
cord-277355-si3g5dih	102	7	have	have	VBP
cord-277355-si3g5dih	102	8	not	not	RB
cord-277355-si3g5dih	102	9	been	be	VBN
cord-277355-si3g5dih	102	10	identified	identify	VBN
cord-277355-si3g5dih	102	11	to	to	IN
cord-277355-si3g5dih	102	12	date	date	NN
cord-277355-si3g5dih	102	13	;	;	:
cord-277355-si3g5dih	102	14	thus	thus	RB
cord-277355-si3g5dih	102	15	,	,	,
cord-277355-si3g5dih	102	16	the	the	DT
cord-277355-si3g5dih	102	17	specific	specific	JJ
cord-277355-si3g5dih	102	18	mechanism	mechanism	NN
cord-277355-si3g5dih	102	19	of	of	IN
cord-277355-si3g5dih	102	20	NC	NC	NNP
cord-277355-si3g5dih	102	21	formation	formation	NN
cord-277355-si3g5dih	102	22	remains	remain	VBZ
cord-277355-si3g5dih	102	23	unclear	unclear	JJ
cord-277355-si3g5dih	102	24	.	.	.
cord-277355-si3g5dih	103	1	The	the	DT
cord-277355-si3g5dih	103	2	nucleocapsid	nucleocapsid	NN
cord-277355-si3g5dih	103	3	-	-	HYPH
cord-277355-si3g5dih	103	4	like	like	JJ
cord-277355-si3g5dih	103	5	particles	particle	NNS
cord-277355-si3g5dih	103	6	(	(	-LRB-
cord-277355-si3g5dih	103	7	NLPs	NLPs	NNP
cord-277355-si3g5dih	103	8	)	)	-RRB-
cord-277355-si3g5dih	103	9	can	can	MD
cord-277355-si3g5dih	103	10	be	be	VB
cord-277355-si3g5dih	103	11	assembled	assemble	VBN
cord-277355-si3g5dih	103	12	in	in	IN
cord-277355-si3g5dih	103	13	vitro	vitro	FW
cord-277355-si3g5dih	103	14	but	but	CC
cord-277355-si3g5dih	103	15	are	be	VBP
cord-277355-si3g5dih	103	16	larger	large	JJR
cord-277355-si3g5dih	103	17	than	than	IN
cord-277355-si3g5dih	103	18	the	the	DT
cord-277355-si3g5dih	103	19	authentic	authentic	JJ
cord-277355-si3g5dih	103	20	NC	NC	NNP
cord-277355-si3g5dih	103	21	,	,	,
cord-277355-si3g5dih	103	22	which	which	WDT
cord-277355-si3g5dih	103	23	may	may	MD
cord-277355-si3g5dih	103	24	be	be	VB
cord-277355-si3g5dih	103	25	attributed	attribute	VBN
cord-277355-si3g5dih	103	26	to	to	IN
cord-277355-si3g5dih	103	27	cellular	cellular	JJ
cord-277355-si3g5dih	103	28	or	or	CC
cord-277355-si3g5dih	103	29	viral	viral	JJ
cord-277355-si3g5dih	103	30	components	component	NNS
cord-277355-si3g5dih	103	31	participating	participate	VBG
cord-277355-si3g5dih	103	32	in	in	IN
cord-277355-si3g5dih	103	33	NC	NC	NNP
cord-277355-si3g5dih	103	34	formation	formation	NN
cord-277355-si3g5dih	103	35	in	in	IN
cord-277355-si3g5dih	103	36	vivo	vivo	NNP
cord-277355-si3g5dih	103	37	[	[	-LRB-
cord-277355-si3g5dih	103	38	17	17	CD
cord-277355-si3g5dih	103	39	,	,	,
cord-277355-si3g5dih	103	40	60	60	CD
cord-277355-si3g5dih	103	41	]	]	-RRB-
cord-277355-si3g5dih	103	42	.	.	.
cord-277355-si3g5dih	104	1	The	the	DT
cord-277355-si3g5dih	104	2	formation	formation	NN
cord-277355-si3g5dih	104	3	of	of	IN
cord-277355-si3g5dih	104	4	CP	cp	NN
cord-277355-si3g5dih	104	5	-	-	HYPH
cord-277355-si3g5dih	104	6	only	only	RB
cord-277355-si3g5dih	104	7	particles	particle	NNS
cord-277355-si3g5dih	104	8	is	be	VBZ
cord-277355-si3g5dih	104	9	unlikely	unlikely	JJ
cord-277355-si3g5dih	104	10	due	due	IN
cord-277355-si3g5dih	104	11	to	to	IN
cord-277355-si3g5dih	104	12	the	the	DT
cord-277355-si3g5dih	104	13	highly	highly	RB
cord-277355-si3g5dih	104	14	positive	positive	JJ
cord-277355-si3g5dih	104	15	charge	charge	NN
cord-277355-si3g5dih	104	16	of	of	IN
cord-277355-si3g5dih	104	17	the	the	DT
cord-277355-si3g5dih	104	18	CP	cp	NN
cord-277355-si3g5dih	104	19	dimer	dimer	NN
cord-277355-si3g5dih	104	20	,	,	,
cord-277355-si3g5dih	104	21	which	which	WDT
cord-277355-si3g5dih	104	22	is	be	VBZ
cord-277355-si3g5dih	104	23	neutralized	neutralize	VBN
cord-277355-si3g5dih	104	24	by	by	IN
cord-277355-si3g5dih	104	25	the	the	DT
cord-277355-si3g5dih	104	26	packaged	package	VBN
cord-277355-si3g5dih	104	27	genome	genome	NN
cord-277355-si3g5dih	104	28	[	[	-LRB-
cord-277355-si3g5dih	104	29	17	17	CD
cord-277355-si3g5dih	104	30	]	]	-RRB-
cord-277355-si3g5dih	104	31	.	.	.
cord-277355-si3g5dih	105	1	In	in	IN
cord-277355-si3g5dih	105	2	cells	cell	NNS
cord-277355-si3g5dih	105	3	,	,	,
cord-277355-si3g5dih	105	4	the	the	DT
cord-277355-si3g5dih	105	5	NC	NC	NNP
cord-277355-si3g5dih	105	6	may	may	MD
cord-277355-si3g5dih	105	7	be	be	VB
cord-277355-si3g5dih	105	8	assembled	assemble	VBN
cord-277355-si3g5dih	105	9	in	in	IN
cord-277355-si3g5dih	105	10	a	a	DT
cord-277355-si3g5dih	105	11	near	near	RB
cord-277355-si3g5dih	105	12	-	-	HYPH
cord-277355-si3g5dih	105	13	neutral	neutral	JJ
cord-277355-si3g5dih	105	14	environment	environment	NN
cord-277355-si3g5dih	105	15	within	within	IN
cord-277355-si3g5dih	105	16	the	the	DT
cord-277355-si3g5dih	105	17	ER	ER	NNP
cord-277355-si3g5dih	105	18	membranous	membranous	JJ
cord-277355-si3g5dih	105	19	compartment	compartment	NN
cord-277355-si3g5dih	105	20	,	,	,
cord-277355-si3g5dih	105	21	which	which	WDT
cord-277355-si3g5dih	105	22	is	be	VBZ
cord-277355-si3g5dih	105	23	physically	physically	RB
cord-277355-si3g5dih	105	24	linked	link	VBN
cord-277355-si3g5dih	105	25	to	to	IN
cord-277355-si3g5dih	105	26	vesicles	vesicle	NNS
cord-277355-si3g5dih	105	27	and	and	CC
cord-277355-si3g5dih	105	28	contains	contain	VBZ
cord-277355-si3g5dih	105	29	the	the	DT
cord-277355-si3g5dih	105	30	prM	prm	JJ
cord-277355-si3g5dih	105	31	-	-	HYPH
cord-277355-si3g5dih	105	32	E	e	NN
cord-277355-si3g5dih	105	33	proteins	protein	NNS
cord-277355-si3g5dih	105	34	[	[	-LRB-
cord-277355-si3g5dih	105	35	61	61	CD
cord-277355-si3g5dih	105	36	]	]	-RRB-
cord-277355-si3g5dih	105	37	.	.	.
cord-277355-si3g5dih	106	1	It	-PRON-	PRP
cord-277355-si3g5dih	106	2	is	be	VBZ
cord-277355-si3g5dih	106	3	believed	believe	VBN
cord-277355-si3g5dih	106	4	that	that	IN
cord-277355-si3g5dih	106	5	viral	viral	JJ
cord-277355-si3g5dih	106	6	encapsidation	encapsidation	NN
cord-277355-si3g5dih	106	7	and	and	CC
cord-277355-si3g5dih	106	8	NC	NC	NNP
cord-277355-si3g5dih	106	9	incorporation	incorporation	NN
cord-277355-si3g5dih	106	10	into	into	IN
cord-277355-si3g5dih	106	11	viral	viral	JJ
cord-277355-si3g5dih	106	12	particles	particle	NNS
cord-277355-si3g5dih	106	13	is	be	VBZ
cord-277355-si3g5dih	106	14	a	a	DT
cord-277355-si3g5dih	106	15	coordinated	coordinated	JJ
cord-277355-si3g5dih	106	16	process	process	NN
cord-277355-si3g5dih	106	17	,	,	,
cord-277355-si3g5dih	106	18	supported	support	VBN
cord-277355-si3g5dih	106	19	by	by	IN
cord-277355-si3g5dih	106	20	the	the	DT
cord-277355-si3g5dih	106	21	fact	fact	NN
cord-277355-si3g5dih	106	22	that	that	IN
cord-277355-si3g5dih	106	23	the	the	DT
cord-277355-si3g5dih	106	24	NC	NC	NNP
cord-277355-si3g5dih	106	25	has	have	VBZ
cord-277355-si3g5dih	106	26	never	never	RB
cord-277355-si3g5dih	106	27	been	be	VBN
cord-277355-si3g5dih	106	28	isolated	isolate	VBN
cord-277355-si3g5dih	106	29	from	from	IN
cord-277355-si3g5dih	106	30	infected	infected	JJ
cord-277355-si3g5dih	106	31	cells	cell	NNS
cord-277355-si3g5dih	106	32	.	.	.
cord-277355-si3g5dih	107	1	Thus	thus	RB
cord-277355-si3g5dih	107	2	,	,	,
cord-277355-si3g5dih	107	3	the	the	DT
cord-277355-si3g5dih	107	4	NC	NC	NNP
cord-277355-si3g5dih	107	5	assembly	assembly	NN
cord-277355-si3g5dih	107	6	process	process	NN
cord-277355-si3g5dih	107	7	and	and	CC
cord-277355-si3g5dih	107	8	the	the	DT
cord-277355-si3g5dih	107	9	NC	NC	NNP
cord-277355-si3g5dih	107	10	structure	structure	NN
cord-277355-si3g5dih	107	11	are	be	VBP
cord-277355-si3g5dih	107	12	still	still	RB
cord-277355-si3g5dih	107	13	elusive	elusive	JJ
cord-277355-si3g5dih	107	14	.	.	.
cord-277355-si3g5dih	108	1	Previous	previous	JJ
cord-277355-si3g5dih	108	2	structural	structural	JJ
cord-277355-si3g5dih	108	3	studies	study	NNS
cord-277355-si3g5dih	108	4	observed	observe	VBD
cord-277355-si3g5dih	108	5	a	a	DT
cord-277355-si3g5dih	108	6	clearly	clearly	RB
cord-277355-si3g5dih	108	7	low	low	JJ
cord-277355-si3g5dih	108	8	-	-	HYPH
cord-277355-si3g5dih	108	9	density	density	NN
cord-277355-si3g5dih	108	10	gap	gap	NN
cord-277355-si3g5dih	108	11	between	between	IN
cord-277355-si3g5dih	108	12	the	the	DT
cord-277355-si3g5dih	108	13	NC	NC	NNP
cord-277355-si3g5dih	108	14	and	and	CC
cord-277355-si3g5dih	108	15	lipid	lipid	NN
cord-277355-si3g5dih	108	16	bilayer	bilayer	NN
cord-277355-si3g5dih	108	17	[	[	-LRB-
cord-277355-si3g5dih	108	18	2,3,54,62	2,3,54,62	ADD
cord-277355-si3g5dih	108	19	]	]	-RRB-
cord-277355-si3g5dih	108	20	;	;	:
cord-277355-si3g5dih	108	21	in	in	IN
cord-277355-si3g5dih	108	22	addition	addition	NN
cord-277355-si3g5dih	108	23	,	,	,
cord-277355-si3g5dih	108	24	unlike	unlike	IN
cord-277355-si3g5dih	108	25	in	in	IN
cord-277355-si3g5dih	108	26	coronavirus	coronavirus	NN
cord-277355-si3g5dih	108	27	and	and	CC
cord-277355-si3g5dih	108	28	hepatitis	hepatitis	NN
cord-277355-si3g5dih	108	29	B	B	NNP
cord-277355-si3g5dih	108	30	virus	virus	NN
cord-277355-si3g5dih	108	31	,	,	,
cord-277355-si3g5dih	108	32	the	the	DT
cord-277355-si3g5dih	108	33	cytoplasmic	cytoplasmic	JJ
cord-277355-si3g5dih	108	34	sides	side	NNS
cord-277355-si3g5dih	108	35	of	of	IN
cord-277355-si3g5dih	108	36	the	the	DT
cord-277355-si3g5dih	108	37	flaviviral	flaviviral	FW
cord-277355-si3g5dih	108	38	prM	prM	NNP
cord-277355-si3g5dih	108	39	and	and	CC
cord-277355-si3g5dih	108	40	E	e	NN
cord-277355-si3g5dih	108	41	proteins	protein	NNS
cord-277355-si3g5dih	108	42	on	on	IN
cord-277355-si3g5dih	108	43	ER	ER	NNP
cord-277355-si3g5dih	108	44	membranes	membrane	NNS
cord-277355-si3g5dih	108	45	are	be	VBP
cord-277355-si3g5dih	108	46	extremely	extremely	RB
cord-277355-si3g5dih	108	47	short	short	JJ
cord-277355-si3g5dih	108	48	and	and	CC
cord-277355-si3g5dih	108	49	are	be	VBP
cord-277355-si3g5dih	108	50	devoid	devoid	JJ
cord-277355-si3g5dih	108	51	of	of	IN
cord-277355-si3g5dih	108	52	a	a	DT
cord-277355-si3g5dih	108	53	distinct	distinct	JJ
cord-277355-si3g5dih	108	54	NC	NC	NNP
cord-277355-si3g5dih	108	55	-	-	HYPH
cord-277355-si3g5dih	108	56	binding	bind	VBG
cord-277355-si3g5dih	108	57	domain	domain	NN
cord-277355-si3g5dih	108	58	[	[	-LRB-
cord-277355-si3g5dih	108	59	20	20	CD
cord-277355-si3g5dih	108	60	]	]	-RRB-
cord-277355-si3g5dih	108	61	.	.	.
cord-277355-si3g5dih	109	1	These	these	DT
cord-277355-si3g5dih	109	2	traits	trait	NNS
cord-277355-si3g5dih	109	3	suggest	suggest	VBP
cord-277355-si3g5dih	109	4	that	that	IN
cord-277355-si3g5dih	109	5	the	the	DT
cord-277355-si3g5dih	109	6	NC	NC	NNP
cord-277355-si3g5dih	109	7	and	and	CC
cord-277355-si3g5dih	109	8	outer	outer	JJ
cord-277355-si3g5dih	109	9	glycoproteins	glycoprotein	NNS
cord-277355-si3g5dih	109	10	may	may	MD
cord-277355-si3g5dih	109	11	not	not	RB
cord-277355-si3g5dih	109	12	directly	directly	RB
cord-277355-si3g5dih	109	13	interact	interact	VB
cord-277355-si3g5dih	109	14	.	.	.
cord-277355-si3g5dih	110	1	However	however	RB
cord-277355-si3g5dih	110	2	,	,	,
cord-277355-si3g5dih	110	3	recently	recently	RB
cord-277355-si3g5dih	110	4	determined	determine	VBD
cord-277355-si3g5dih	110	5	structures	structure	NNS
cord-277355-si3g5dih	110	6	at	at	IN
cord-277355-si3g5dih	110	7	higher	high	JJR
cord-277355-si3g5dih	110	8	resolutions	resolution	NNS
cord-277355-si3g5dih	110	9	showed	show	VBD
cord-277355-si3g5dih	110	10	that	that	IN
cord-277355-si3g5dih	110	11	the	the	DT
cord-277355-si3g5dih	110	12	NC	NC	NNP
cord-277355-si3g5dih	110	13	is	be	VBZ
cord-277355-si3g5dih	110	14	asymmetrically	asymmetrically	RB
cord-277355-si3g5dih	110	15	positioned	position	VBN
cord-277355-si3g5dih	110	16	with	with	IN
cord-277355-si3g5dih	110	17	respect	respect	NN
cord-277355-si3g5dih	110	18	to	to	IN
cord-277355-si3g5dih	110	19	the	the	DT
cord-277355-si3g5dih	110	20	outer	outer	JJ
cord-277355-si3g5dih	110	21	glycoprotein	glycoprotein	NN
cord-277355-si3g5dih	110	22	shell	shell	NN
cord-277355-si3g5dih	110	23	in	in	IN
cord-277355-si3g5dih	110	24	both	both	DT
cord-277355-si3g5dih	110	25	immature	immature	JJ
cord-277355-si3g5dih	110	26	KUNV	KUNV	NNPS
cord-277355-si3g5dih	110	27	[	[	-LRB-
cord-277355-si3g5dih	110	28	56	56	CD
cord-277355-si3g5dih	110	29	]	]	-RRB-
cord-277355-si3g5dih	110	30	;	;	:
cord-277355-si3g5dih	110	31	however	however	RB
cord-277355-si3g5dih	110	32	,	,	,
cord-277355-si3g5dih	110	33	NC	NC	NNP
cord-277355-si3g5dih	110	34	is	be	VBZ
cord-277355-si3g5dih	110	35	still	still	RB
cord-277355-si3g5dih	110	36	positioned	position	VBN
cord-277355-si3g5dih	110	37	concentrically	concentrically	RB
cord-277355-si3g5dih	110	38	with	with	IN
cord-277355-si3g5dih	110	39	the	the	DT
cord-277355-si3g5dih	110	40	outer	outer	JJ
cord-277355-si3g5dih	110	41	glycoprotein	glycoprotein	NN
cord-277355-si3g5dih	110	42	shell	shell	NN
cord-277355-si3g5dih	110	43	in	in	IN
cord-277355-si3g5dih	110	44	mature	mature	JJ
cord-277355-si3g5dih	110	45	virions	virion	NNS
cord-277355-si3g5dih	110	46	[	[	-LRB-
cord-277355-si3g5dih	110	47	6	6	CD
cord-277355-si3g5dih	110	48	,	,	,
cord-277355-si3g5dih	110	49	56	56	CD
cord-277355-si3g5dih	110	50	]	]	-RRB-
cord-277355-si3g5dih	110	51	,	,	,
cord-277355-si3g5dih	110	52	suggesting	suggest	VBG
cord-277355-si3g5dih	110	53	a	a	DT
cord-277355-si3g5dih	110	54	rearrangement	rearrangement	NN
cord-277355-si3g5dih	110	55	of	of	IN
cord-277355-si3g5dih	110	56	the	the	DT
cord-277355-si3g5dih	110	57	NC	NC	NNP
cord-277355-si3g5dih	110	58	during	during	IN
cord-277355-si3g5dih	110	59	viral	viral	JJ
cord-277355-si3g5dih	110	60	maturation	maturation	NN
cord-277355-si3g5dih	110	61	.	.	.
cord-277355-si3g5dih	111	1	According	accord	VBG
cord-277355-si3g5dih	111	2	to	to	IN
cord-277355-si3g5dih	111	3	these	these	DT
cord-277355-si3g5dih	111	4	structural	structural	JJ
cord-277355-si3g5dih	111	5	studies	study	NNS
cord-277355-si3g5dih	111	6	,	,	,
cord-277355-si3g5dih	111	7	a	a	DT
cord-277355-si3g5dih	111	8	model	model	NN
cord-277355-si3g5dih	111	9	for	for	IN
cord-277355-si3g5dih	111	10	flaviviral	flaviviral	FW
cord-277355-si3g5dih	111	11	budding	budding	NN
cord-277355-si3g5dih	111	12	was	be	VBD
cord-277355-si3g5dih	111	13	put	put	VBN
cord-277355-si3g5dih	111	14	forward	forward	RB
cord-277355-si3g5dih	111	15	:	:	:
cord-277355-si3g5dih	111	16	the	the	DT
cord-277355-si3g5dih	111	17	NCs	NCs	NNP
cord-277355-si3g5dih	111	18	interact	interact	VBP
cord-277355-si3g5dih	111	19	with	with	IN
cord-277355-si3g5dih	111	20	glycoproteins	glycoprotein	NNS
cord-277355-si3g5dih	111	21	at	at	IN
cord-277355-si3g5dih	111	22	the	the	DT
cord-277355-si3g5dih	111	23	beginning	beginning	NN
cord-277355-si3g5dih	111	24	of	of	IN
cord-277355-si3g5dih	111	25	viral	viral	JJ
cord-277355-si3g5dih	111	26	budding	budding	NN
cord-277355-si3g5dih	111	27	and	and	CC
cord-277355-si3g5dih	111	28	form	form	VB
cord-277355-si3g5dih	111	29	an	an	DT
cord-277355-si3g5dih	111	30	immature	immature	JJ
cord-277355-si3g5dih	111	31	virion	virion	NN
cord-277355-si3g5dih	111	32	with	with	IN
cord-277355-si3g5dih	111	33	an	an	DT
cord-277355-si3g5dih	111	34	eccentrically	eccentrically	RB
cord-277355-si3g5dih	111	35	positioned	position	VBN
cord-277355-si3g5dih	111	36	NC	NC	NNP
cord-277355-si3g5dih	111	37	core	core	NN
cord-277355-si3g5dih	111	38	;	;	:
cord-277355-si3g5dih	111	39	during	during	IN
cord-277355-si3g5dih	111	40	viral	viral	JJ
cord-277355-si3g5dih	111	41	maturation	maturation	NN
cord-277355-si3g5dih	111	42	,	,	,
cord-277355-si3g5dih	111	43	the	the	DT
cord-277355-si3g5dih	111	44	conformational	conformational	JJ
cord-277355-si3g5dih	111	45	rearrangements	rearrangement	NNS
cord-277355-si3g5dih	111	46	of	of	IN
cord-277355-si3g5dih	111	47	outer	outer	JJ
cord-277355-si3g5dih	111	48	glycoproteins	glycoprotein	NNS
cord-277355-si3g5dih	111	49	possibly	possibly	RB
cord-277355-si3g5dih	111	50	result	result	VBP
cord-277355-si3g5dih	111	51	in	in	IN
cord-277355-si3g5dih	111	52	loosening	loosening	NN
cord-277355-si3g5dih	111	53	of	of	IN
cord-277355-si3g5dih	111	54	NC	NC	NNP
cord-277355-si3g5dih	111	55	-	-	HYPH
cord-277355-si3g5dih	111	56	glycoprotein	glycoprotein	NN
cord-277355-si3g5dih	111	57	interactions	interaction	NNS
cord-277355-si3g5dih	111	58	and	and	CC
cord-277355-si3g5dih	111	59	release	release	NN
cord-277355-si3g5dih	111	60	of	of	IN
cord-277355-si3g5dih	111	61	the	the	DT
cord-277355-si3g5dih	111	62	NC	NC	NNP
cord-277355-si3g5dih	111	63	core	core	NN
cord-277355-si3g5dih	111	64	to	to	IN
cord-277355-si3g5dih	111	65	the	the	DT
cord-277355-si3g5dih	111	66	center	center	NN
cord-277355-si3g5dih	111	67	[	[	-LRB-
cord-277355-si3g5dih	111	68	56	56	CD
cord-277355-si3g5dih	111	69	]	]	-RRB-
cord-277355-si3g5dih	111	70	.	.	.
cord-277355-si3g5dih	112	1	Recent	recent	JJ
cord-277355-si3g5dih	112	2	studies	study	NNS
cord-277355-si3g5dih	112	3	have	have	VBP
cord-277355-si3g5dih	112	4	also	also	RB
cord-277355-si3g5dih	112	5	proposed	propose	VBN
cord-277355-si3g5dih	112	6	a	a	DT
cord-277355-si3g5dih	112	7	general	general	JJ
cord-277355-si3g5dih	112	8	model	model	NN
cord-277355-si3g5dih	112	9	for	for	IN
cord-277355-si3g5dih	112	10	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	112	11	virion	virion	NNP
cord-277355-si3g5dih	112	12	assembly	assembly	NNP
cord-277355-si3g5dih	112	13	.	.	.
cord-277355-si3g5dih	113	1	In	in	IN
cord-277355-si3g5dih	113	2	this	this	DT
cord-277355-si3g5dih	113	3	model	model	NN
cord-277355-si3g5dih	113	4	,	,	,
cord-277355-si3g5dih	113	5	the	the	DT
cord-277355-si3g5dih	113	6	transmembrane	transmembrane	NN
cord-277355-si3g5dih	113	7	protein	protein	NN
cord-277355-si3g5dih	113	8	NS2A	NS2A	NNP
cord-277355-si3g5dih	113	9	plays	play	VBZ
cord-277355-si3g5dih	113	10	a	a	DT
cord-277355-si3g5dih	113	11	central	central	JJ
cord-277355-si3g5dih	113	12	role	role	NN
cord-277355-si3g5dih	113	13	in	in	IN
cord-277355-si3g5dih	113	14	orchestrating	orchestrate	VBG
cord-277355-si3g5dih	113	15	virion	virion	NN
cord-277355-si3g5dih	113	16	assembly	assembly	NN
cord-277355-si3g5dih	113	17	[	[	-LRB-
cord-277355-si3g5dih	113	18	63	63	CD
cord-277355-si3g5dih	113	19	]	]	-RRB-
cord-277355-si3g5dih	113	20	.	.	.
cord-277355-si3g5dih	114	1	SVPs	svp	NNS
cord-277355-si3g5dih	114	2	are	be	VBP
cord-277355-si3g5dih	114	3	routinely	routinely	RB
cord-277355-si3g5dih	114	4	generated	generate	VBN
cord-277355-si3g5dih	114	5	as	as	IN
cord-277355-si3g5dih	114	6	a	a	DT
cord-277355-si3g5dih	114	7	byproduct	byproduct	NN
cord-277355-si3g5dih	114	8	in	in	IN
cord-277355-si3g5dih	114	9	flavivirusinfected	flavivirusinfected	JJ
cord-277355-si3g5dih	114	10	cell	cell	NN
cord-277355-si3g5dih	114	11	cultures	culture	NNS
cord-277355-si3g5dih	114	12	;	;	,
cord-277355-si3g5dih	114	13	secreted	secrete	VBN
cord-277355-si3g5dih	114	14	particles	particle	NNS
cord-277355-si3g5dih	114	15	contain	contain	VBP
cord-277355-si3g5dih	114	16	only	only	RB
cord-277355-si3g5dih	114	17	the	the	DT
cord-277355-si3g5dih	114	18	M	M	NNP
cord-277355-si3g5dih	114	19	and	and	CC
cord-277355-si3g5dih	114	20	E	e	NN
cord-277355-si3g5dih	114	21	proteins	protein	NNS
cord-277355-si3g5dih	114	22	and	and	CC
cord-277355-si3g5dih	114	23	lipid	lipid	NN
cord-277355-si3g5dih	114	24	membrane	membrane	NN
cord-277355-si3g5dih	114	25	but	but	CC
cord-277355-si3g5dih	114	26	lack	lack	VBP
cord-277355-si3g5dih	114	27	the	the	DT
cord-277355-si3g5dih	114	28	NC	NC	NNP
cord-277355-si3g5dih	114	29	core	core	NN
cord-277355-si3g5dih	114	30	.	.	.
cord-277355-si3g5dih	115	1	Similar	similar	JJ
cord-277355-si3g5dih	115	2	recombinant	recombinant	JJ
cord-277355-si3g5dih	115	3	SVPs	svp	NNS
cord-277355-si3g5dih	115	4	can	can	MD
cord-277355-si3g5dih	115	5	be	be	VB
cord-277355-si3g5dih	115	6	produced	produce	VBN
cord-277355-si3g5dih	115	7	by	by	IN
cord-277355-si3g5dih	115	8	coexpressing	coexpresse	VBG
cord-277355-si3g5dih	115	9	the	the	DT
cord-277355-si3g5dih	115	10	prM	prm	JJ
cord-277355-si3g5dih	115	11	and	and	CC
cord-277355-si3g5dih	115	12	E	e	NN
cord-277355-si3g5dih	115	13	proteins	protein	NNS
cord-277355-si3g5dih	115	14	in	in	IN
cord-277355-si3g5dih	115	15	cell	cell	NN
cord-277355-si3g5dih	115	16	culture	culture	NN
cord-277355-si3g5dih	115	17	.	.	.
cord-277355-si3g5dih	116	1	The	the	DT
cord-277355-si3g5dih	116	2	assembly	assembly	NN
cord-277355-si3g5dih	116	3	and	and	CC
cord-277355-si3g5dih	116	4	budding	budding	NN
cord-277355-si3g5dih	116	5	of	of	IN
cord-277355-si3g5dih	116	6	these	these	DT
cord-277355-si3g5dih	116	7	particles	particle	NNS
cord-277355-si3g5dih	116	8	occur	occur	VBP
cord-277355-si3g5dih	116	9	in	in	IN
cord-277355-si3g5dih	116	10	an	an	DT
cord-277355-si3g5dih	116	11	NC	NC	NNP
cord-277355-si3g5dih	116	12	-	-	HYPH
cord-277355-si3g5dih	116	13	independent	independent	JJ
cord-277355-si3g5dih	116	14	manner	manner	NN
cord-277355-si3g5dih	116	15	;	;	:
cord-277355-si3g5dih	116	16	however	however	RB
cord-277355-si3g5dih	116	17	,	,	,
cord-277355-si3g5dih	116	18	these	these	DT
cord-277355-si3g5dih	116	19	particles	particle	NNS
cord-277355-si3g5dih	116	20	undergo	undergo	VBP
cord-277355-si3g5dih	116	21	the	the	DT
cord-277355-si3g5dih	116	22	same	same	JJ
cord-277355-si3g5dih	116	23	maturation	maturation	NN
cord-277355-si3g5dih	116	24	and	and	CC
cord-277355-si3g5dih	116	25	transport	transport	NN
cord-277355-si3g5dih	116	26	process	process	NN
cord-277355-si3g5dih	116	27	as	as	IN
cord-277355-si3g5dih	116	28	whole	whole	JJ
cord-277355-si3g5dih	116	29	virions	virion	NNS
cord-277355-si3g5dih	116	30	[	[	-LRB-
cord-277355-si3g5dih	116	31	64	64	CD
cord-277355-si3g5dih	116	32	]	]	-RRB-
cord-277355-si3g5dih	116	33	.	.	.
cord-277355-si3g5dih	117	1	Two	two	CD
cord-277355-si3g5dih	117	2	distinct	distinct	JJ
cord-277355-si3g5dih	117	3	sizes	size	NNS
cord-277355-si3g5dih	117	4	of	of	IN
cord-277355-si3g5dih	117	5	recombinant	recombinant	JJ
cord-277355-si3g5dih	117	6	SVPs	svp	NNS
cord-277355-si3g5dih	117	7	were	be	VBD
cord-277355-si3g5dih	117	8	observed	observe	VBN
cord-277355-si3g5dih	117	9	in	in	IN
cord-277355-si3g5dih	117	10	TBEV	TBEV	NNP
cord-277355-si3g5dih	117	11	;	;	:
cord-277355-si3g5dih	117	12	however	however	RB
cord-277355-si3g5dih	117	13	,	,	,
cord-277355-si3g5dih	117	14	smaller	small	JJR
cord-277355-si3g5dih	117	15	SVPs	svp	NNS
cord-277355-si3g5dih	117	16	(	(	-LRB-
cord-277355-si3g5dih	117	17	approximately	approximately	RB
cord-277355-si3g5dih	117	18	30	30	CD
cord-277355-si3g5dih	117	19	nm	nm	NN
cord-277355-si3g5dih	117	20	in	in	IN
cord-277355-si3g5dih	117	21	diameter	diameter	NN
cord-277355-si3g5dih	117	22	)	)	-RRB-
cord-277355-si3g5dih	117	23	were	be	VBD
cord-277355-si3g5dih	117	24	far	far	RB
cord-277355-si3g5dih	117	25	more	more	RBR
cord-277355-si3g5dih	117	26	prevalent	prevalent	JJ
cord-277355-si3g5dih	117	27	than	than	IN
cord-277355-si3g5dih	117	28	the	the	DT
cord-277355-si3g5dih	117	29	larger	large	JJR
cord-277355-si3g5dih	117	30	SVPs	svp	NNS
cord-277355-si3g5dih	117	31	(	(	-LRB-
cord-277355-si3g5dih	117	32	approximately	approximately	RB
cord-277355-si3g5dih	117	33	50	50	CD
cord-277355-si3g5dih	117	34	nm	nm	NN
cord-277355-si3g5dih	117	35	in	in	IN
cord-277355-si3g5dih	117	36	diameter	diameter	NN
cord-277355-si3g5dih	117	37	)	)	-RRB-
cord-277355-si3g5dih	118	1	[	[	-LRB-
cord-277355-si3g5dih	118	2	65	65	CD
cord-277355-si3g5dih	118	3	]	]	-RRB-
cord-277355-si3g5dih	118	4	.	.	.
cord-277355-si3g5dih	119	1	A	a	DT
cord-277355-si3g5dih	119	2	structural	structural	JJ
cord-277355-si3g5dih	119	3	study	study	NN
cord-277355-si3g5dih	119	4	revealed	reveal	VBD
cord-277355-si3g5dih	119	5	that	that	IN
cord-277355-si3g5dih	119	6	the	the	DT
cord-277355-si3g5dih	119	7	orga	orga	NNP
cord-277355-si3g5dih	119	8	-	-	HYPH
cord-277355-si3g5dih	119	9	nization	nization	NN
cord-277355-si3g5dih	119	10	of	of	IN
cord-277355-si3g5dih	119	11	the	the	DT
cord-277355-si3g5dih	119	12	E	e	NN
cord-277355-si3g5dih	119	13	protein	protein	NN
cord-277355-si3g5dih	119	14	is	be	VBZ
cord-277355-si3g5dih	119	15	different	different	JJ
cord-277355-si3g5dih	119	16	in	in	IN
cord-277355-si3g5dih	119	17	SVPs	svp	NNS
cord-277355-si3g5dih	119	18	than	than	IN
cord-277355-si3g5dih	119	19	in	in	IN
cord-277355-si3g5dih	119	20	the	the	DT
cord-277355-si3g5dih	119	21	whole	whole	JJ
cord-277355-si3g5dih	119	22	virus	virus	NN
cord-277355-si3g5dih	119	23	[	[	-LRB-
cord-277355-si3g5dih	119	24	66	66	CD
cord-277355-si3g5dih	119	25	]	]	-RRB-
cord-277355-si3g5dih	119	26	,	,	,
cord-277355-si3g5dih	119	27	but	but	CC
cord-277355-si3g5dih	119	28	SVPs	svp	NNS
cord-277355-si3g5dih	119	29	show	show	VBP
cord-277355-si3g5dih	119	30	hemagglutination	hemagglutination	NN
cord-277355-si3g5dih	119	31	and	and	CC
cord-277355-si3g5dih	119	32	fusion	fusion	NN
cord-277355-si3g5dih	119	33	activities	activity	NNS
cord-277355-si3g5dih	119	34	similar	similar	JJ
cord-277355-si3g5dih	119	35	to	to	IN
cord-277355-si3g5dih	119	36	those	those	DT
cord-277355-si3g5dih	119	37	of	of	IN
cord-277355-si3g5dih	119	38	whole	whole	JJ
cord-277355-si3g5dih	119	39	virions	virion	NNS
cord-277355-si3g5dih	119	40	and	and	CC
cord-277355-si3g5dih	119	41	have	have	VBP
cord-277355-si3g5dih	119	42	been	be	VBN
cord-277355-si3g5dih	119	43	proven	prove	VBN
cord-277355-si3g5dih	119	44	to	to	TO
cord-277355-si3g5dih	119	45	be	be	VB
cord-277355-si3g5dih	119	46	excellent	excellent	JJ
cord-277355-si3g5dih	119	47	immunogens	immunogen	NNS
cord-277355-si3g5dih	119	48	with	with	IN
cord-277355-si3g5dih	119	49	protective	protective	JJ
cord-277355-si3g5dih	119	50	capability	capability	NN
cord-277355-si3g5dih	119	51	[	[	-LRB-
cord-277355-si3g5dih	119	52	28	28	CD
cord-277355-si3g5dih	119	53	,	,	,
cord-277355-si3g5dih	119	54	67	67	CD
cord-277355-si3g5dih	119	55	,	,	,
cord-277355-si3g5dih	119	56	68	68	CD
cord-277355-si3g5dih	119	57	]	]	-RRB-
cord-277355-si3g5dih	119	58	.	.	.
cord-277355-si3g5dih	120	1	In	in	IN
cord-277355-si3g5dih	120	2	viral	viral	JJ
cord-277355-si3g5dih	120	3	infection	infection	NN
cord-277355-si3g5dih	120	4	,	,	,
cord-277355-si3g5dih	120	5	how	how	WRB
cord-277355-si3g5dih	120	6	the	the	DT
cord-277355-si3g5dih	120	7	NC	NC	NNP
cord-277355-si3g5dih	120	8	is	be	VBZ
cord-277355-si3g5dih	120	9	dissociated	dissociate	VBN
cord-277355-si3g5dih	120	10	and	and	CC
cord-277355-si3g5dih	120	11	how	how	WRB
cord-277355-si3g5dih	120	12	vRNA	vrna	JJ
cord-277355-si3g5dih	120	13	is	be	VBZ
cord-277355-si3g5dih	120	14	released	release	VBN
cord-277355-si3g5dih	120	15	to	to	TO
cord-277355-si3g5dih	120	16	enable	enable	VB
cord-277355-si3g5dih	120	17	protein	protein	NN
cord-277355-si3g5dih	120	18	synthesis	synthesis	NN
cord-277355-si3g5dih	120	19	are	be	VBP
cord-277355-si3g5dih	120	20	still	still	RB
cord-277355-si3g5dih	120	21	unknown	unknown	JJ
cord-277355-si3g5dih	120	22	steps	step	NNS
cord-277355-si3g5dih	120	23	in	in	IN
cord-277355-si3g5dih	120	24	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	120	25	biology	biology	NN
cord-277355-si3g5dih	120	26	because	because	IN
cord-277355-si3g5dih	120	27	there	there	EX
cord-277355-si3g5dih	120	28	is	be	VBZ
cord-277355-si3g5dih	120	29	little	little	JJ
cord-277355-si3g5dih	120	30	research	research	NN
cord-277355-si3g5dih	120	31	data	datum	NNS
cord-277355-si3g5dih	120	32	for	for	IN
cord-277355-si3g5dih	120	33	this	this	DT
cord-277355-si3g5dih	120	34	process	process	NN
cord-277355-si3g5dih	120	35	to	to	IN
cord-277355-si3g5dih	120	36	date	date	NN
cord-277355-si3g5dih	120	37	.	.	.
cord-277355-si3g5dih	121	1	Tracing	trace	VBG
cord-277355-si3g5dih	121	2	the	the	DT
cord-277355-si3g5dih	121	3	fate	fate	NN
cord-277355-si3g5dih	121	4	of	of	IN
cord-277355-si3g5dih	121	5	DENV	DENV	NNP
cord-277355-si3g5dih	121	6	CP	CP	NNP
cord-277355-si3g5dih	121	7	after	after	IN
cord-277355-si3g5dih	121	8	viral	viral	JJ
cord-277355-si3g5dih	121	9	entry	entry	NN
cord-277355-si3g5dih	121	10	,	,	,
cord-277355-si3g5dih	121	11	we	-PRON-	PRP
cord-277355-si3g5dih	121	12	found	find	VBD
cord-277355-si3g5dih	121	13	that	that	IN
cord-277355-si3g5dih	121	14	CP	CP	NNP
cord-277355-si3g5dih	121	15	was	be	VBD
cord-277355-si3g5dih	121	16	degraded	degrade	VBN
cord-277355-si3g5dih	121	17	after	after	IN
cord-277355-si3g5dih	121	18	internalization	internalization	NN
cord-277355-si3g5dih	121	19	by	by	IN
cord-277355-si3g5dih	121	20	a	a	DT
cord-277355-si3g5dih	121	21	ubiquitin	ubiquitin	NN
cord-277355-si3g5dih	121	22	proteasomedependent	proteasomedependent	NN
cord-277355-si3g5dih	121	23	process	process	NN
cord-277355-si3g5dih	121	24	;	;	:
cord-277355-si3g5dih	121	25	however	however	RB
cord-277355-si3g5dih	121	26	,	,	,
cord-277355-si3g5dih	121	27	mutational	mutational	JJ
cord-277355-si3g5dih	121	28	analysis	analysis	NN
cord-277355-si3g5dih	121	29	revealed	reveal	VBD
cord-277355-si3g5dih	121	30	that	that	IN
cord-277355-si3g5dih	121	31	DENV	DENV	NNP
cord-277355-si3g5dih	121	32	CP	cp	NN
cord-277355-si3g5dih	121	33	ubiquitination	ubiquitination	NN
cord-277355-si3g5dih	121	34	occurs	occur	VBZ
cord-277355-si3g5dih	121	35	at	at	IN
cord-277355-si3g5dih	121	36	noncanonical	noncanonical	JJ
cord-277355-si3g5dih	121	37	residues	residue	NNS
cord-277355-si3g5dih	121	38	but	but	CC
cord-277355-si3g5dih	121	39	not	not	RB
cord-277355-si3g5dih	121	40	Lys	Lys	NNP
cord-277355-si3g5dih	121	41	residues	residue	NNS
cord-277355-si3g5dih	121	42	[	[	-LRB-
cord-277355-si3g5dih	121	43	69	69	CD
cord-277355-si3g5dih	121	44	]	]	-RRB-
cord-277355-si3g5dih	121	45	.	.	.
cord-277355-si3g5dih	122	1	A	a	DT
cord-277355-si3g5dih	122	2	deletion	deletion	NN
cord-277355-si3g5dih	122	3	mutation	mutation	NN
cord-277355-si3g5dih	122	4	study	study	NN
cord-277355-si3g5dih	122	5	of	of	IN
cord-277355-si3g5dih	122	6	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	122	7	CP	CP	NNP
cord-277355-si3g5dih	122	8	using	use	VBG
cord-277355-si3g5dih	122	9	an	an	DT
cord-277355-si3g5dih	122	10	infectious	infectious	JJ
cord-277355-si3g5dih	122	11	clone	clone	NN
cord-277355-si3g5dih	122	12	indicated	indicate	VBD
cord-277355-si3g5dih	122	13	that	that	IN
cord-277355-si3g5dih	122	14	the	the	DT
cord-277355-si3g5dih	122	15	a3-helix	a3-helix	NN
cord-277355-si3g5dih	122	16	may	may	MD
cord-277355-si3g5dih	122	17	also	also	RB
cord-277355-si3g5dih	122	18	affect	affect	VB
cord-277355-si3g5dih	122	19	NC	NC	NNP
cord-277355-si3g5dih	122	20	uncoating	uncoating	NN
cord-277355-si3g5dih	122	21	steps	step	NNS
cord-277355-si3g5dih	122	22	[	[	-LRB-
cord-277355-si3g5dih	122	23	33	33	CD
cord-277355-si3g5dih	122	24	]	]	-RRB-
cord-277355-si3g5dih	122	25	.	.	.
cord-277355-si3g5dih	123	1	These	these	DT
cord-277355-si3g5dih	123	2	data	datum	NNS
cord-277355-si3g5dih	123	3	indicate	indicate	VBP
cord-277355-si3g5dih	123	4	that	that	IN
cord-277355-si3g5dih	123	5	both	both	CC
cord-277355-si3g5dih	123	6	viral	viral	JJ
cord-277355-si3g5dih	123	7	and	and	CC
cord-277355-si3g5dih	123	8	host	host	NN
cord-277355-si3g5dih	123	9	factors	factor	NNS
cord-277355-si3g5dih	123	10	are	be	VBP
cord-277355-si3g5dih	123	11	possibly	possibly	RB
cord-277355-si3g5dih	123	12	involved	involved	JJ
cord-277355-si3g5dih	123	13	in	in	IN
cord-277355-si3g5dih	123	14	the	the	DT
cord-277355-si3g5dih	123	15	viral	viral	JJ
cord-277355-si3g5dih	123	16	NC	NC	NNP
cord-277355-si3g5dih	123	17	uncoating	uncoating	NN
cord-277355-si3g5dih	123	18	process	process	NN
cord-277355-si3g5dih	123	19	;	;	:
cord-277355-si3g5dih	123	20	however	however	RB
cord-277355-si3g5dih	123	21	,	,	,
cord-277355-si3g5dih	123	22	as	as	IN
cord-277355-si3g5dih	123	23	one	one	CD
cord-277355-si3g5dih	123	24	of	of	IN
cord-277355-si3g5dih	123	25	the	the	DT
cord-277355-si3g5dih	123	26	most	most	RBS
cord-277355-si3g5dih	123	27	understudied	understudied	JJ
cord-277355-si3g5dih	123	28	viral	viral	JJ
cord-277355-si3g5dih	123	29	processes	process	NNS
cord-277355-si3g5dih	123	30	in	in	IN
cord-277355-si3g5dih	123	31	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	123	32	,	,	,
cord-277355-si3g5dih	123	33	further	further	JJ
cord-277355-si3g5dih	123	34	attention	attention	NN
cord-277355-si3g5dih	123	35	is	be	VBZ
cord-277355-si3g5dih	123	36	urgently	urgently	RB
cord-277355-si3g5dih	123	37	needed	need	VBN
cord-277355-si3g5dih	123	38	to	to	TO
cord-277355-si3g5dih	123	39	clarify	clarify	VB
cord-277355-si3g5dih	123	40	the	the	DT
cord-277355-si3g5dih	123	41	molecular	molecular	JJ
cord-277355-si3g5dih	123	42	mechanism	mechanism	NN
cord-277355-si3g5dih	123	43	of	of	IN
cord-277355-si3g5dih	123	44	the	the	DT
cord-277355-si3g5dih	123	45	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	123	46	uncoating	uncoating	NN
cord-277355-si3g5dih	123	47	process	process	NN
cord-277355-si3g5dih	123	48	.	.	.
cord-277355-si3g5dih	124	1	Due	due	IN
cord-277355-si3g5dih	124	2	to	to	IN
cord-277355-si3g5dih	124	3	increasing	increase	VBG
cord-277355-si3g5dih	124	4	transnational	transnational	JJ
cord-277355-si3g5dih	124	5	communication	communication	NN
cord-277355-si3g5dih	124	6	and	and	CC
cord-277355-si3g5dih	124	7	climatic	climatic	JJ
cord-277355-si3g5dih	124	8	and	and	CC
cord-277355-si3g5dih	124	9	socioeconomic	socioeconomic	JJ
cord-277355-si3g5dih	124	10	changes	change	NNS
cord-277355-si3g5dih	124	11	,	,	,
cord-277355-si3g5dih	124	12	emerging	emerge	VBG
cord-277355-si3g5dih	124	13	and	and	CC
cord-277355-si3g5dih	124	14	reemerging	reemerge	VBG
cord-277355-si3g5dih	124	15	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	124	16	have	have	VBP
cord-277355-si3g5dih	124	17	caused	cause	VBN
cord-277355-si3g5dih	124	18	an	an	DT
cord-277355-si3g5dih	124	19	ever	ever	RB
cord-277355-si3g5dih	124	20	-	-	HYPH
cord-277355-si3g5dih	124	21	growing	grow	VBG
cord-277355-si3g5dih	124	22	threat	threat	NN
cord-277355-si3g5dih	124	23	to	to	IN
cord-277355-si3g5dih	124	24	global	global	JJ
cord-277355-si3g5dih	124	25	public	public	JJ
cord-277355-si3g5dih	124	26	health	health	NN
cord-277355-si3g5dih	124	27	;	;	:
cord-277355-si3g5dih	124	28	a	a	DT
cord-277355-si3g5dih	124	29	recent	recent	JJ
cord-277355-si3g5dih	124	30	example	example	NN
cord-277355-si3g5dih	124	31	of	of	IN
cord-277355-si3g5dih	124	32	this	this	DT
cord-277355-si3g5dih	124	33	issue	issue	NN
cord-277355-si3g5dih	124	34	is	be	VBZ
cord-277355-si3g5dih	124	35	the	the	DT
cord-277355-si3g5dih	124	36	rapid	rapid	JJ
cord-277355-si3g5dih	124	37	and	and	CC
cord-277355-si3g5dih	124	38	wide	wide	JJ
cord-277355-si3g5dih	124	39	spread	spread	NN
cord-277355-si3g5dih	124	40	of	of	IN
cord-277355-si3g5dih	124	41	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	124	42	throughout	throughout	IN
cord-277355-si3g5dih	124	43	the	the	DT
cord-277355-si3g5dih	124	44	Americas	Americas	NNPS
cord-277355-si3g5dih	124	45	since	since	IN
cord-277355-si3g5dih	124	46	2015	2015	CD
cord-277355-si3g5dih	124	47	[	[	-LRB-
cord-277355-si3g5dih	124	48	70	70	CD
cord-277355-si3g5dih	124	49	]	]	-RRB-
cord-277355-si3g5dih	124	50	.	.	.
cord-277355-si3g5dih	125	1	There	there	EX
cord-277355-si3g5dih	125	2	is	be	VBZ
cord-277355-si3g5dih	125	3	currently	currently	RB
cord-277355-si3g5dih	125	4	no	no	DT
cord-277355-si3g5dih	125	5	efficient	efficient	JJ
cord-277355-si3g5dih	125	6	medical	medical	JJ
cord-277355-si3g5dih	125	7	treatment	treatment	NN
cord-277355-si3g5dih	125	8	against	against	IN
cord-277355-si3g5dih	125	9	these	these	DT
cord-277355-si3g5dih	125	10	important	important	JJ
cord-277355-si3g5dih	125	11	viral	viral	JJ
cord-277355-si3g5dih	125	12	diseases	disease	NNS
cord-277355-si3g5dih	125	13	;	;	:
cord-277355-si3g5dih	125	14	thus	thus	RB
cord-277355-si3g5dih	125	15	,	,	,
cord-277355-si3g5dih	125	16	safe	safe	JJ
cord-277355-si3g5dih	125	17	and	and	CC
cord-277355-si3g5dih	125	18	efficacious	efficacious	JJ
cord-277355-si3g5dih	125	19	vaccines	vaccine	NNS
cord-277355-si3g5dih	125	20	are	be	VBP
cord-277355-si3g5dih	125	21	of	of	IN
cord-277355-si3g5dih	125	22	great	great	JJ
cord-277355-si3g5dih	125	23	importance	importance	NN
cord-277355-si3g5dih	125	24	for	for	IN
cord-277355-si3g5dih	125	25	preventing	prevent	VBG
cord-277355-si3g5dih	125	26	viral	viral	JJ
cord-277355-si3g5dih	125	27	infection	infection	NN
cord-277355-si3g5dih	125	28	and	and	CC
cord-277355-si3g5dih	125	29	spread	spread	NN
cord-277355-si3g5dih	125	30	.	.	.
cord-277355-si3g5dih	126	1	In	in	IN
cord-277355-si3g5dih	126	2	many	many	JJ
cord-277355-si3g5dih	126	3	respects	respect	NNS
cord-277355-si3g5dih	126	4	,	,	,
cord-277355-si3g5dih	126	5	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	126	6	vac-	vac-	NNP
cord-277355-si3g5dih	126	7	cine	cine	NNP
cord-277355-si3g5dih	126	8	development	development	NNP
cord-277355-si3g5dih	126	9	has	have	VBZ
cord-277355-si3g5dih	126	10	historically	historically	RB
cord-277355-si3g5dih	126	11	achieved	achieve	VBN
cord-277355-si3g5dih	126	12	success	success	NN
cord-277355-si3g5dih	126	13	,	,	,
cord-277355-si3g5dih	126	14	such	such	JJ
cord-277355-si3g5dih	126	15	as	as	IN
cord-277355-si3g5dih	126	16	the	the	DT
cord-277355-si3g5dih	126	17	most	most	RBS
cord-277355-si3g5dih	126	18	successful	successful	JJ
cord-277355-si3g5dih	126	19	live	live	RB
cord-277355-si3g5dih	126	20	-	-	HYPH
cord-277355-si3g5dih	126	21	attenuated	attenuated	JJ
cord-277355-si3g5dih	126	22	vaccine	vaccine	NN
cord-277355-si3g5dih	126	23	YF-17D	YF-17D	NNP
cord-277355-si3g5dih	126	24	and	and	CC
cord-277355-si3g5dih	126	25	many	many	JJ
cord-277355-si3g5dih	126	26	other	other	JJ
cord-277355-si3g5dih	126	27	live	live	RB
cord-277355-si3g5dih	126	28	-	-	HYPH
cord-277355-si3g5dih	126	29	attenuated	attenuate	VBN
cord-277355-si3g5dih	126	30	or	or	CC
cord-277355-si3g5dih	126	31	inactivated	inactivate	VBN
cord-277355-si3g5dih	126	32	vaccines	vaccine	NNS
cord-277355-si3g5dih	126	33	against	against	IN
cord-277355-si3g5dih	126	34	YFV	YFV	NNP
cord-277355-si3g5dih	126	35	,	,	,
cord-277355-si3g5dih	126	36	JEV	JEV	NNP
cord-277355-si3g5dih	126	37	and	and	CC
cord-277355-si3g5dih	126	38	TBEV	TBEV	NNP
cord-277355-si3g5dih	126	39	infection	infection	NN
cord-277355-si3g5dih	126	40	[	[	-LRB-
cord-277355-si3g5dih	126	41	71	71	CD
cord-277355-si3g5dih	126	42	]	]	-RRB-
cord-277355-si3g5dih	126	43	.	.	.
cord-277355-si3g5dih	127	1	However	however	RB
cord-277355-si3g5dih	127	2	,	,	,
cord-277355-si3g5dih	127	3	concerns	concern	NNS
cord-277355-si3g5dih	127	4	about	about	IN
cord-277355-si3g5dih	127	5	safety	safety	NN
cord-277355-si3g5dih	127	6	have	have	VBP
cord-277355-si3g5dih	127	7	been	be	VBN
cord-277355-si3g5dih	127	8	raised	raise	VBN
cord-277355-si3g5dih	127	9	regarding	regard	VBG
cord-277355-si3g5dih	127	10	adverse	adverse	JJ
cord-277355-si3g5dih	127	11	reactions	reaction	NNS
cord-277355-si3g5dih	127	12	observed	observe	VBN
cord-277355-si3g5dih	127	13	with	with	IN
cord-277355-si3g5dih	127	14	YF-17D	YF-17D	NNP
cord-277355-si3g5dih	127	15	and	and	CC
cord-277355-si3g5dih	127	16	inactivated	inactivate	VBD
cord-277355-si3g5dih	127	17	JEV	JEV	NNP
cord-277355-si3g5dih	127	18	vaccines	vaccine	NNS
cord-277355-si3g5dih	127	19	[	[	-LRB-
cord-277355-si3g5dih	127	20	72	72	CD
cord-277355-si3g5dih	127	21	,	,	,
cord-277355-si3g5dih	127	22	73	73	CD
cord-277355-si3g5dih	127	23	]	]	-RRB-
cord-277355-si3g5dih	127	24	.	.	.
cord-277355-si3g5dih	128	1	In	in	IN
cord-277355-si3g5dih	128	2	addition	addition	NN
cord-277355-si3g5dih	128	3	,	,	,
cord-277355-si3g5dih	128	4	there	there	EX
cord-277355-si3g5dih	128	5	are	be	VBP
cord-277355-si3g5dih	128	6	still	still	RB
cord-277355-si3g5dih	128	7	no	no	DT
cord-277355-si3g5dih	128	8	available	available	JJ
cord-277355-si3g5dih	128	9	vaccines	vaccine	NNS
cord-277355-si3g5dih	128	10	for	for	IN
cord-277355-si3g5dih	128	11	human	human	NN
cord-277355-si3g5dih	128	12	against	against	IN
cord-277355-si3g5dih	128	13	WNV	WNV	NNP
cord-277355-si3g5dih	128	14	and	and	CC
cord-277355-si3g5dih	128	15	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	128	16	,	,	,
cord-277355-si3g5dih	128	17	and	and	CC
cord-277355-si3g5dih	128	18	the	the	DT
cord-277355-si3g5dih	128	19	only	only	JJ
cord-277355-si3g5dih	128	20	licensed	license	VBN
cord-277355-si3g5dih	128	21	DENV	DENV	NNP
cord-277355-si3g5dih	128	22	vaccine	vaccine	NN
cord-277355-si3g5dih	128	23	is	be	VBZ
cord-277355-si3g5dih	128	24	also	also	RB
cord-277355-si3g5dih	128	25	less	less	JJR
cord-277355-si3g5dih	128	26	than	than	IN
cord-277355-si3g5dih	128	27	satisfactory	satisfactory	JJ
cord-277355-si3g5dih	128	28	for	for	IN
cord-277355-si3g5dih	128	29	its	-PRON-	PRP$
cord-277355-si3g5dih	128	30	efficacy	efficacy	NN
cord-277355-si3g5dih	128	31	and	and	CC
cord-277355-si3g5dih	128	32	safety	safety	NN
cord-277355-si3g5dih	128	33	[	[	-LRB-
cord-277355-si3g5dih	128	34	71	71	CD
cord-277355-si3g5dih	128	35	,	,	,
cord-277355-si3g5dih	128	36	74	74	CD
cord-277355-si3g5dih	128	37	]	]	-RRB-
cord-277355-si3g5dih	128	38	.	.	.
cord-277355-si3g5dih	129	1	Hence	hence	RB
cord-277355-si3g5dih	129	2	,	,	,
cord-277355-si3g5dih	129	3	innovative	innovative	JJ
cord-277355-si3g5dih	129	4	vaccine	vaccine	NN
cord-277355-si3g5dih	129	5	development	development	NN
cord-277355-si3g5dih	129	6	must	must	MD
cord-277355-si3g5dih	129	7	meet	meet	VB
cord-277355-si3g5dih	129	8	the	the	DT
cord-277355-si3g5dih	129	9	stringent	stringent	JJ
cord-277355-si3g5dih	129	10	need	need	NN
cord-277355-si3g5dih	129	11	for	for	IN
cord-277355-si3g5dih	129	12	safety	safety	NN
cord-277355-si3g5dih	129	13	,	,	,
cord-277355-si3g5dih	129	14	efficacy	efficacy	NN
cord-277355-si3g5dih	129	15	and	and	CC
cord-277355-si3g5dih	129	16	cost	cost	NN
cord-277355-si3g5dih	129	17	effectiveness	effectiveness	NN
cord-277355-si3g5dih	129	18	and	and	CC
cord-277355-si3g5dih	129	19	face	face	VB
cord-277355-si3g5dih	129	20	the	the	DT
cord-277355-si3g5dih	129	21	challenge	challenge	NN
cord-277355-si3g5dih	129	22	of	of	IN
cord-277355-si3g5dih	129	23	the	the	DT
cord-277355-si3g5dih	129	24	complicated	complicated	JJ
cord-277355-si3g5dih	129	25	pathogenesis	pathogenesis	NN
cord-277355-si3g5dih	129	26	of	of	IN
cord-277355-si3g5dih	129	27	some	some	DT
cord-277355-si3g5dih	129	28	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	129	29	[	[	-LRB-
cord-277355-si3g5dih	129	30	19	19	CD
cord-277355-si3g5dih	129	31	]	]	-RRB-
cord-277355-si3g5dih	129	32	.	.	.
cord-277355-si3g5dih	130	1	Manipulation	manipulation	NN
cord-277355-si3g5dih	130	2	of	of	IN
cord-277355-si3g5dih	130	3	reverse	reverse	JJ
cord-277355-si3g5dih	130	4	genetics	genetics	NN
cord-277355-si3g5dih	130	5	technology	technology	NN
cord-277355-si3g5dih	130	6	has	have	VBZ
cord-277355-si3g5dih	130	7	identified	identify	VBN
cord-277355-si3g5dih	130	8	CP	CP	NNP
cord-277355-si3g5dih	130	9	as	as	IN
cord-277355-si3g5dih	130	10	a	a	DT
cord-277355-si3g5dih	130	11	target	target	NN
cord-277355-si3g5dih	130	12	for	for	IN
cord-277355-si3g5dih	130	13	flaviviral	flaviviral	NNP
cord-277355-si3g5dih	130	14	vaccine	vaccine	NN
cord-277355-si3g5dih	130	15	development	development	NN
cord-277355-si3g5dih	130	16	;	;	:
cord-277355-si3g5dih	130	17	both	both	DT
cord-277355-si3g5dih	130	18	live	live	RB
cord-277355-si3g5dih	130	19	-	-	HYPH
cord-277355-si3g5dih	130	20	attenuated	attenuate	VBN
cord-277355-si3g5dih	130	21	and	and	CC
cord-277355-si3g5dih	130	22	new	new	JJ
cord-277355-si3g5dih	130	23	-	-	HYPH
cord-277355-si3g5dih	130	24	style	style	NN
cord-277355-si3g5dih	130	25	replicon	replicon	NN
cord-277355-si3g5dih	130	26	vaccines	vaccine	NNS
cord-277355-si3g5dih	130	27	can	can	MD
cord-277355-si3g5dih	130	28	be	be	VB
cord-277355-si3g5dih	130	29	generated	generate	VBN
cord-277355-si3g5dih	130	30	by	by	IN
cord-277355-si3g5dih	130	31	introducing	introduce	VBG
cord-277355-si3g5dih	130	32	different	different	JJ
cord-277355-si3g5dih	130	33	sizes	size	NNS
cord-277355-si3g5dih	130	34	of	of	IN
cord-277355-si3g5dih	130	35	deletions	deletion	NNS
cord-277355-si3g5dih	130	36	into	into	IN
cord-277355-si3g5dih	130	37	the	the	DT
cord-277355-si3g5dih	130	38	CP	cp	NN
cord-277355-si3g5dih	130	39	gene	gene	NN
cord-277355-si3g5dih	130	40	of	of	IN
cord-277355-si3g5dih	130	41	the	the	DT
cord-277355-si3g5dih	130	42	viral	viral	JJ
cord-277355-si3g5dih	130	43	genome	genome	NN
cord-277355-si3g5dih	130	44	(	(	-LRB-
cord-277355-si3g5dih	130	45	Fig	Fig	NNP
cord-277355-si3g5dih	130	46	.	.	NNP
cord-277355-si3g5dih	130	47	2	2	CD
cord-277355-si3g5dih	130	48	)	)	-RRB-
cord-277355-si3g5dih	130	49	.	.	.
cord-277355-si3g5dih	131	1	We	-PRON-	PRP
cord-277355-si3g5dih	131	2	summarize	summarize	VBP
cord-277355-si3g5dih	131	3	these	these	DT
cord-277355-si3g5dih	131	4	reports	report	NNS
cord-277355-si3g5dih	131	5	here	here	RB
cord-277355-si3g5dih	131	6	,	,	,
cord-277355-si3g5dih	131	7	and	and	CC
cord-277355-si3g5dih	131	8	the	the	DT
cord-277355-si3g5dih	131	9	potential	potential	JJ
cord-277355-si3g5dih	131	10	benefits	benefit	NNS
cord-277355-si3g5dih	131	11	are	be	VBP
cord-277355-si3g5dih	131	12	discussed	discuss	VBN
cord-277355-si3g5dih	131	13	.	.	.
cord-277355-si3g5dih	132	1	As	as	IN
cord-277355-si3g5dih	132	2	mentioned	mention	VBN
cord-277355-si3g5dih	132	3	above	above	RB
cord-277355-si3g5dih	132	4	,	,	,
cord-277355-si3g5dih	132	5	the	the	DT
cord-277355-si3g5dih	132	6	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	132	7	CPs	cp	NNS
cord-277355-si3g5dih	132	8	display	display	VBP
cord-277355-si3g5dih	132	9	significant	significant	JJ
cord-277355-si3g5dih	132	10	flexibility	flexibility	NN
cord-277355-si3g5dih	132	11	in	in	IN
cord-277355-si3g5dih	132	12	structure	structure	NN
cord-277355-si3g5dih	132	13	and	and	CC
cord-277355-si3g5dih	132	14	function	function	NN
cord-277355-si3g5dih	132	15	.	.	.
cord-277355-si3g5dih	133	1	Introducing	introduce	VBG
cord-277355-si3g5dih	133	2	different	different	JJ
cord-277355-si3g5dih	133	3	sizes	size	NNS
cord-277355-si3g5dih	133	4	of	of	IN
cord-277355-si3g5dih	133	5	deletions	deletion	NNS
cord-277355-si3g5dih	133	6	into	into	IN
cord-277355-si3g5dih	133	7	CP	CP	NNP
cord-277355-si3g5dih	133	8	resulted	result	VBD
cord-277355-si3g5dih	133	9	in	in	IN
cord-277355-si3g5dih	133	10	various	various	JJ
cord-277355-si3g5dih	133	11	degrees	degree	NNS
cord-277355-si3g5dih	133	12	of	of	IN
cord-277355-si3g5dih	133	13	attenuation	attenuation	NN
cord-277355-si3g5dih	133	14	of	of	IN
cord-277355-si3g5dih	133	15	viral	viral	JJ
cord-277355-si3g5dih	133	16	replication	replication	NN
cord-277355-si3g5dih	133	17	in	in	IN
cord-277355-si3g5dih	133	18	vitro	vitro	FW
cord-277355-si3g5dih	133	19	.	.	.
cord-277355-si3g5dih	134	1	Do	do	VBP
cord-277355-si3g5dih	134	2	deletions	deletion	NNS
cord-277355-si3g5dih	134	3	in	in	IN
cord-277355-si3g5dih	134	4	CP	CP	NNP
cord-277355-si3g5dih	134	5	also	also	RB
cord-277355-si3g5dih	134	6	affect	affect	VBP
cord-277355-si3g5dih	134	7	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	134	8	virulence	virulence	NN
cord-277355-si3g5dih	134	9	in	in	IN
cord-277355-si3g5dih	134	10	vivo	vivo	NN
cord-277355-si3g5dih	134	11	?	?	.
cord-277355-si3g5dih	135	1	Assessing	assess	VBG
cord-277355-si3g5dih	135	2	the	the	DT
cord-277355-si3g5dih	135	3	50	50	CD
cord-277355-si3g5dih	135	4	%	%	NN
cord-277355-si3g5dih	135	5	lethal	lethal	JJ
cord-277355-si3g5dih	135	6	dose	dose	NN
cord-277355-si3g5dih	135	7	(	(	-LRB-
cord-277355-si3g5dih	135	8	LD	LD	NNP
cord-277355-si3g5dih	135	9	50	50	CD
cord-277355-si3g5dih	135	10	)	)	-RRB-
cord-277355-si3g5dih	135	11	and	and	CC
cord-277355-si3g5dih	135	12	the	the	DT
cord-277355-si3g5dih	135	13	50	50	CD
cord-277355-si3g5dih	135	14	%	%	NN
cord-277355-si3g5dih	135	15	infective	infective	JJ
cord-277355-si3g5dih	135	16	dose	dose	NN
cord-277355-si3g5dih	135	17	(	(	-LRB-
cord-277355-si3g5dih	135	18	ID	ID	NNP
cord-277355-si3g5dih	135	19	50	50	CD
cord-277355-si3g5dih	135	20	)	)	-RRB-
cord-277355-si3g5dih	135	21	of	of	IN
cord-277355-si3g5dih	135	22	TBEV	TBEV	NNP
cord-277355-si3g5dih	135	23	DC	DC	NNP
cord-277355-si3g5dih	135	24	mutants	mutant	NNS
cord-277355-si3g5dih	135	25	in	in	IN
cord-277355-si3g5dih	135	26	mouse	mouse	NN
cord-277355-si3g5dih	135	27	models	model	NNS
cord-277355-si3g5dih	135	28	,	,	,
cord-277355-si3g5dih	135	29	it	-PRON-	PRP
cord-277355-si3g5dih	135	30	was	be	VBD
cord-277355-si3g5dih	135	31	found	find	VBN
cord-277355-si3g5dih	135	32	that	that	IN
cord-277355-si3g5dih	135	33	a	a	DT
cord-277355-si3g5dih	135	34	small	small	JJ
cord-277355-si3g5dih	135	35	deletion	deletion	NN
cord-277355-si3g5dih	135	36	mutant	mutant	NN
cord-277355-si3g5dih	135	37	(	(	-LRB-
cord-277355-si3g5dih	135	38	CD28	CD28	NNP
cord-277355-si3g5dih	135	39	-	-	HYPH
cord-277355-si3g5dih	135	40	31	31	CD
cord-277355-si3g5dih	135	41	)	)	-RRB-
cord-277355-si3g5dih	135	42	exhibited	exhibit	VBD
cord-277355-si3g5dih	135	43	virulence	virulence	NN
cord-277355-si3g5dih	135	44	indistinguishable	indistinguishable	JJ
cord-277355-si3g5dih	135	45	from	from	IN
cord-277355-si3g5dih	135	46	that	that	DT
cord-277355-si3g5dih	135	47	of	of	IN
cord-277355-si3g5dih	135	48	the	the	DT
cord-277355-si3g5dih	135	49	wild	wild	JJ
cord-277355-si3g5dih	135	50	type	type	NN
cord-277355-si3g5dih	135	51	,	,	,
cord-277355-si3g5dih	135	52	but	but	CC
cord-277355-si3g5dih	135	53	a	a	DT
cord-277355-si3g5dih	135	54	viable	viable	JJ
cord-277355-si3g5dih	135	55	mutant	mutant	NN
cord-277355-si3g5dih	135	56	with	with	IN
cord-277355-si3g5dih	135	57	a	a	DT
cord-277355-si3g5dih	135	58	large	large	JJ
cord-277355-si3g5dih	135	59	deletion	deletion	NN
cord-277355-si3g5dih	135	60	(	(	-LRB-
cord-277355-si3g5dih	135	61	CD28	CD28	NNP
cord-277355-si3g5dih	135	62	-	-	HYPH
cord-277355-si3g5dih	135	63	35	35	CD
cord-277355-si3g5dih	135	64	)	)	-RRB-
cord-277355-si3g5dih	135	65	in	in	IN
cord-277355-si3g5dih	135	66	the	the	DT
cord-277355-si3g5dih	135	67	first	first	JJ
cord-277355-si3g5dih	135	68	group	group	NN
cord-277355-si3g5dih	135	69	was	be	VBD
cord-277355-si3g5dih	135	70	highly	highly	RB
cord-277355-si3g5dih	135	71	attenuated	attenuate	VBN
cord-277355-si3g5dih	135	72	,	,	,
cord-277355-si3g5dih	135	73	with	with	IN
cord-277355-si3g5dih	135	74	a	a	DT
cord-277355-si3g5dih	135	75	much	much	RB
cord-277355-si3g5dih	135	76	higher	high	JJR
cord-277355-si3g5dih	135	77	LD	LD	NNP
cord-277355-si3g5dih	135	78	50	50	CD
cord-277355-si3g5dih	135	79	than	than	IN
cord-277355-si3g5dih	135	80	the	the	DT
cord-277355-si3g5dih	135	81	wild	wild	JJ
cord-277355-si3g5dih	135	82	-	-	HYPH
cord-277355-si3g5dih	135	83	type	type	NN
cord-277355-si3g5dih	135	84	virus	virus	NN
cord-277355-si3g5dih	135	85	(	(	-LRB-
cord-277355-si3g5dih	135	86	!	!	.
cord-277355-si3g5dih	136	1	10	10	CD
cord-277355-si3g5dih	136	2	6.5	6.5	CD
cord-277355-si3g5dih	136	3	PFU	pfu	NN
cord-277355-si3g5dih	136	4	versus	versus	IN
cord-277355-si3g5dih	136	5	10	10	CD
cord-277355-si3g5dih	136	6	0.9	0.9	CD
cord-277355-si3g5dih	136	7	PFU	pfu	NN
cord-277355-si3g5dih	136	8	)	)	-RRB-
cord-277355-si3g5dih	136	9	[	[	-LRB-
cord-277355-si3g5dih	136	10	20	20	CD
cord-277355-si3g5dih	136	11	]	]	-RRB-
cord-277355-si3g5dih	136	12	;	;	:
cord-277355-si3g5dih	136	13	the	the	DT
cord-277355-si3g5dih	136	14	pseudorevertants	pseudorevertant	NNS
cord-277355-si3g5dih	137	1	C(D28	C(D28	NNP
cord-277355-si3g5dih	137	2	-	-	HYPH
cord-277355-si3g5dih	137	3	48	48	CD
cord-277355-si3g5dih	137	4	/	/	SYM
cord-277355-si3g5dih	137	5	Du78	Du78	NNP
cord-277355-si3g5dih	137	6	-	-	HYPH
cord-277355-si3g5dih	137	7	85	85	CD
cord-277355-si3g5dih	137	8	)	)	-RRB-
cord-277355-si3g5dih	137	9	and	and	CC
cord-277355-si3g5dih	137	10	C(D28	C(D28	NNP
cord-277355-si3g5dih	137	11	-	-	HYPH
cord-277355-si3g5dih	137	12	48	48	CD
cord-277355-si3g5dih	137	13	/	/	SYM
cord-277355-si3g5dih	137	14	Q70L	Q70L	NNP
cord-277355-si3g5dih	137	15	)	)	-RRB-
cord-277355-si3g5dih	137	16	were	be	VBD
cord-277355-si3g5dih	137	17	equally	equally	RB
cord-277355-si3g5dih	137	18	attenuated	attenuated	JJ
cord-277355-si3g5dih	137	19	(	(	-LRB-
cord-277355-si3g5dih	138	1	LD	LD	NNP
cord-277355-si3g5dih	138	2	50	50	CD
cord-277355-si3g5dih	138	3	!	!	.
cord-277355-si3g5dih	139	1	10	10	CD
cord-277355-si3g5dih	139	2	6.5	6.5	CD
cord-277355-si3g5dih	139	3	PFU	pfu	NN
cord-277355-si3g5dih	139	4	)	)	-RRB-
cord-277355-si3g5dih	139	5	but	but	CC
cord-277355-si3g5dih	139	6	more	more	RBR
cord-277355-si3g5dih	139	7	infective	infective	JJ
cord-277355-si3g5dih	139	8	than	than	IN
cord-277355-si3g5dih	139	9	the	the	DT
cord-277355-si3g5dih	139	10	mutant	mutant	JJ
cord-277355-si3g5dih	139	11	CD28	CD28	NNP
cord-277355-si3g5dih	139	12	-	-	HYPH
cord-277355-si3g5dih	139	13	35	35	CD
cord-277355-si3g5dih	139	14	(	(	-LRB-
cord-277355-si3g5dih	139	15	ID	ID	NNP
cord-277355-si3g5dih	139	16	50	50	CD
cord-277355-si3g5dih	139	17	of	of	IN
cord-277355-si3g5dih	139	18	10	10	CD
cord-277355-si3g5dih	139	19	PFU	pfu	NN
cord-277355-si3g5dih	139	20	versus	versus	IN
cord-277355-si3g5dih	139	21	10	10	CD
cord-277355-si3g5dih	139	22	2.6	2.6	CD
cord-277355-si3g5dih	139	23	PFU	pfu	NN
cord-277355-si3g5dih	139	24	)	)	-RRB-
cord-277355-si3g5dih	139	25	,	,	,
cord-277355-si3g5dih	139	26	so	so	IN
cord-277355-si3g5dih	139	27	a	a	DT
cord-277355-si3g5dih	139	28	larger	large	JJR
cord-277355-si3g5dih	139	29	attenuation	attenuation	NN
cord-277355-si3g5dih	139	30	index	index	NN
cord-277355-si3g5dih	139	31	was	be	VBD
cord-277355-si3g5dih	139	32	achieved	achieve	VBN
cord-277355-si3g5dih	139	33	(	(	-LRB-
cord-277355-si3g5dih	139	34	up	up	IN
cord-277355-si3g5dih	139	35	to	to	TO
cord-277355-si3g5dih	139	36	10	10	CD
cord-277355-si3g5dih	139	37	5.5	5.5	CD
cord-277355-si3g5dih	139	38	,	,	,
cord-277355-si3g5dih	139	39	calculated	calculate	VBN
cord-277355-si3g5dih	139	40	from	from	IN
cord-277355-si3g5dih	139	41	the	the	DT
cord-277355-si3g5dih	139	42	ratio	ratio	NN
cord-277355-si3g5dih	139	43	of	of	IN
cord-277355-si3g5dih	139	44	the	the	DT
cord-277355-si3g5dih	139	45	LD	LD	NNP
cord-277355-si3g5dih	140	1	50	50	CD
cord-277355-si3g5dih	140	2	/ID	/id	SYM
cord-277355-si3g5dih	140	3	50	50	CD
cord-277355-si3g5dih	140	4	)	)	-RRB-
cord-277355-si3g5dih	140	5	[	[	-LRB-
cord-277355-si3g5dih	140	6	9	9	CD
cord-277355-si3g5dih	140	7	,	,	,
cord-277355-si3g5dih	140	8	19	19	CD
cord-277355-si3g5dih	140	9	]	]	-RRB-
cord-277355-si3g5dih	140	10	.	.	.
cord-277355-si3g5dih	141	1	More	more	RBR
cord-277355-si3g5dih	141	2	importantly	importantly	RB
cord-277355-si3g5dih	141	3	,	,	,
cord-277355-si3g5dih	141	4	upon	upon	IN
cord-277355-si3g5dih	141	5	inoculation	inoculation	NN
cord-277355-si3g5dih	141	6	with	with	IN
cord-277355-si3g5dih	141	7	any	any	DT
cord-277355-si3g5dih	141	8	of	of	IN
cord-277355-si3g5dih	141	9	the	the	DT
cord-277355-si3g5dih	141	10	mutants	mutant	NNS
cord-277355-si3g5dih	141	11	,	,	,
cord-277355-si3g5dih	141	12	all	all	PDT
cord-277355-si3g5dih	141	13	the	the	DT
cord-277355-si3g5dih	141	14	seroconverted	seroconverte	VBN
cord-277355-si3g5dih	141	15	mice	mouse	NNS
cord-277355-si3g5dih	141	16	survived	survive	VBD
cord-277355-si3g5dih	141	17	a	a	DT
cord-277355-si3g5dih	141	18	challenge	challenge	NN
cord-277355-si3g5dih	141	19	with	with	IN
cord-277355-si3g5dih	141	20	a	a	DT
cord-277355-si3g5dih	141	21	lethal	lethal	JJ
cord-277355-si3g5dih	141	22	dose	dose	NN
cord-277355-si3g5dih	141	23	of	of	IN
cord-277355-si3g5dih	141	24	wild	wild	JJ
cord-277355-si3g5dih	141	25	-	-	HYPH
cord-277355-si3g5dih	141	26	type	type	NN
cord-277355-si3g5dih	141	27	virus	virus	NN
cord-277355-si3g5dih	141	28	;	;	:
cord-277355-si3g5dih	141	29	in	in	IN
cord-277355-si3g5dih	141	30	other	other	JJ
cord-277355-si3g5dih	141	31	words	word	NNS
cord-277355-si3g5dih	141	32	,	,	,
cord-277355-si3g5dih	141	33	the	the	DT
cord-277355-si3g5dih	141	34	50	50	CD
cord-277355-si3g5dih	141	35	%	%	NN
cord-277355-si3g5dih	141	36	protective	protective	JJ
cord-277355-si3g5dih	141	37	dose	dose	NN
cord-277355-si3g5dih	141	38	was	be	VBD
cord-277355-si3g5dih	141	39	equal	equal	JJ
cord-277355-si3g5dih	141	40	to	to	IN
cord-277355-si3g5dih	141	41	the	the	DT
cord-277355-si3g5dih	141	42	ID	ID	NNP
cord-277355-si3g5dih	141	43	50	50	CD
cord-277355-si3g5dih	141	44	,	,	,
cord-277355-si3g5dih	141	45	indicating	indicate	VBG
cord-277355-si3g5dih	141	46	that	that	IN
cord-277355-si3g5dih	141	47	all	all	DT
cord-277355-si3g5dih	141	48	of	of	IN
cord-277355-si3g5dih	141	49	these	these	DT
cord-277355-si3g5dih	141	50	mutants	mutant	NNS
cord-277355-si3g5dih	141	51	elicited	elicit	VBD
cord-277355-si3g5dih	141	52	a	a	DT
cord-277355-si3g5dih	141	53	protective	protective	JJ
cord-277355-si3g5dih	141	54	immunity	immunity	NN
cord-277355-si3g5dih	141	55	and	and	CC
cord-277355-si3g5dih	141	56	are	be	VBP
cord-277355-si3g5dih	141	57	ideal	ideal	JJ
cord-277355-si3g5dih	141	58	and	and	CC
cord-277355-si3g5dih	141	59	highly	highly	RB
cord-277355-si3g5dih	141	60	efficient	efficient	JJ
cord-277355-si3g5dih	141	61	immunogens	immunogen	NNS
cord-277355-si3g5dih	141	62	[	[	-LRB-
cord-277355-si3g5dih	141	63	9	9	CD
cord-277355-si3g5dih	141	64	,	,	,
cord-277355-si3g5dih	141	65	19	19	CD
cord-277355-si3g5dih	141	66	,	,	,
cord-277355-si3g5dih	141	67	20	20	CD
cord-277355-si3g5dih	141	68	]	]	-RRB-
cord-277355-si3g5dih	141	69	.	.	.
cord-277355-si3g5dih	142	1	In	in	IN
cord-277355-si3g5dih	142	2	addition	addition	NN
cord-277355-si3g5dih	142	3	to	to	IN
cord-277355-si3g5dih	142	4	TBEV	TBEV	NNP
cord-277355-si3g5dih	142	5	,	,	,
cord-277355-si3g5dih	142	6	DENV2	denv2	NN
cord-277355-si3g5dih	142	7	DC	DC	NNP
cord-277355-si3g5dih	142	8	mutants	mutant	NNS
cord-277355-si3g5dih	142	9	that	that	WDT
cord-277355-si3g5dih	142	10	were	be	VBD
cord-277355-si3g5dih	142	11	tested	test	VBN
cord-277355-si3g5dih	142	12	in	in	IN
cord-277355-si3g5dih	142	13	vivo	vivo	NNP
cord-277355-si3g5dih	142	14	also	also	RB
cord-277355-si3g5dih	142	15	showed	show	VBD
cord-277355-si3g5dih	142	16	significant	significant	JJ
cord-277355-si3g5dih	142	17	attenuation	attenuation	NN
cord-277355-si3g5dih	142	18	in	in	IN
cord-277355-si3g5dih	142	19	suckling	suckle	VBG
cord-277355-si3g5dih	142	20	mice	mouse	NNS
cord-277355-si3g5dih	142	21	and	and	CC
cord-277355-si3g5dih	142	22	efficiently	efficiently	RB
cord-277355-si3g5dih	142	23	induced	induce	VBN
cord-277355-si3g5dih	142	24	high	high	JJ
cord-277355-si3g5dih	142	25	antibody	antibody	NN
cord-277355-si3g5dih	142	26	titers	titer	NNS
cord-277355-si3g5dih	142	27	in	in	IN
cord-277355-si3g5dih	142	28	adult	adult	NN
cord-277355-si3g5dih	142	29	mice	mouse	NNS
cord-277355-si3g5dih	142	30	[	[	-LRB-
cord-277355-si3g5dih	142	31	75	75	CD
cord-277355-si3g5dih	142	32	]	]	-RRB-
cord-277355-si3g5dih	142	33	.	.	.
cord-277355-si3g5dih	143	1	Additionally	additionally	RB
cord-277355-si3g5dih	143	2	,	,	,
cord-277355-si3g5dih	143	3	DC	DC	NNP
cord-277355-si3g5dih	143	4	pseudorevertants	pseudorevertant	NNS
cord-277355-si3g5dih	143	5	of	of	IN
cord-277355-si3g5dih	143	6	WNV	WNV	NNP
cord-277355-si3g5dih	143	7	did	do	VBD
cord-277355-si3g5dih	143	8	not	not	RB
cord-277355-si3g5dih	143	9	cause	cause	VB
cord-277355-si3g5dih	143	10	disease	disease	NN
cord-277355-si3g5dih	143	11	but	but	CC
cord-277355-si3g5dih	143	12	could	could	MD
cord-277355-si3g5dih	143	13	induce	induce	VB
cord-277355-si3g5dih	143	14	protective	protective	JJ
cord-277355-si3g5dih	143	15	immunity	immunity	NN
cord-277355-si3g5dih	143	16	even	even	RB
cord-277355-si3g5dih	143	17	at	at	IN
cord-277355-si3g5dih	143	18	doses	dose	NNS
cord-277355-si3g5dih	143	19	of	of	IN
cord-277355-si3g5dih	143	20	10	10	CD
cord-277355-si3g5dih	143	21	1	1	CD
cord-277355-si3g5dih	143	22	-10	-10	CD
cord-277355-si3g5dih	143	23	6	6	CD
cord-277355-si3g5dih	143	24	FFU	FFU	NNP
cord-277355-si3g5dih	143	25	[	[	-LRB-
cord-277355-si3g5dih	143	26	76	76	CD
cord-277355-si3g5dih	143	27	]	]	-RRB-
cord-277355-si3g5dih	143	28	.	.	.
cord-277355-si3g5dih	144	1	Interestingly	interestingly	RB
cord-277355-si3g5dih	144	2	,	,	,
cord-277355-si3g5dih	144	3	a	a	DT
cord-277355-si3g5dih	144	4	study	study	NN
cord-277355-si3g5dih	144	5	showed	show	VBD
cord-277355-si3g5dih	144	6	that	that	IN
cord-277355-si3g5dih	144	7	a	a	DT
cord-277355-si3g5dih	144	8	CD61	CD61	NNP
cord-277355-si3g5dih	144	9	-	-	HYPH
cord-277355-si3g5dih	144	10	71	71	CD
cord-277355-si3g5dih	144	11	mutant	mutant	NN
cord-277355-si3g5dih	144	12	had	have	VBD
cord-277355-si3g5dih	144	13	abolished	abolish	VBN
cord-277355-si3g5dih	144	14	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	144	15	infectious	infectious	JJ
cord-277355-si3g5dih	144	16	virion	virion	NN
cord-277355-si3g5dih	144	17	production	production	NN
cord-277355-si3g5dih	144	18	that	that	WDT
cord-277355-si3g5dih	144	19	was	be	VBD
cord-277355-si3g5dih	144	20	then	then	RB
cord-277355-si3g5dih	144	21	restored	restore	VBN
cord-277355-si3g5dih	144	22	by	by	IN
cord-277355-si3g5dih	144	23	adaptive	adaptive	JJ
cord-277355-si3g5dih	144	24	mutations	mutation	NNS
cord-277355-si3g5dih	145	1	(	(	-LRB-
cord-277355-si3g5dih	145	2	prM	prm	JJ
cord-277355-si3g5dih	145	3	-	-	HYPH
cord-277355-si3g5dih	145	4	E21	E21	NNP
cord-277355-si3g5dih	145	5	K	K	NNP
cord-277355-si3g5dih	145	6	and	and	CC
cord-277355-si3g5dih	145	7	NS2B	NS2B	NNP
cord-277355-si3g5dih	145	8	-	-	HYPH
cord-277355-si3g5dih	145	9	E27	E27	NNP
cord-277355-si3g5dih	145	10	G	G	NNP
cord-277355-si3g5dih	145	11	)	)	-RRB-
cord-277355-si3g5dih	145	12	only	only	RB
cord-277355-si3g5dih	145	13	in	in	IN
cord-277355-si3g5dih	145	14	BHK21	BHK21	NNP
cord-277355-si3g5dih	145	15	cells	cell	NNS
cord-277355-si3g5dih	145	16	but	but	CC
cord-277355-si3g5dih	145	17	not	not	RB
cord-277355-si3g5dih	145	18	in	in	IN
cord-277355-si3g5dih	145	19	other	other	JJ
cord-277355-si3g5dih	145	20	cell	cell	NN
cord-277355-si3g5dih	145	21	lines	line	NNS
cord-277355-si3g5dih	145	22	(	(	-LRB-
cord-277355-si3g5dih	145	23	indicate	indicate	VBP
cord-277355-si3g5dih	145	24	complex	complex	JJ
cord-277355-si3g5dih	145	25	interactions	interaction	NNS
cord-277355-si3g5dih	145	26	that	that	WDT
cord-277355-si3g5dih	145	27	apparently	apparently	RB
cord-277355-si3g5dih	145	28	occur	occur	VBP
cord-277355-si3g5dih	145	29	between	between	IN
cord-277355-si3g5dih	145	30	structural	structural	JJ
cord-277355-si3g5dih	145	31	and	and	CC
cord-277355-si3g5dih	145	32	non	non	JJ
cord-277355-si3g5dih	145	33	-	-	JJ
cord-277355-si3g5dih	145	34	structural	structural	JJ
cord-277355-si3g5dih	145	35	proteins	protein	NNS
cord-277355-si3g5dih	145	36	during	during	IN
cord-277355-si3g5dih	145	37	virus	virus	NN
cord-277355-si3g5dih	145	38	replication	replication	NN
cord-277355-si3g5dih	145	39	and/or	and/or	CC
cord-277355-si3g5dih	145	40	assembly	assembly	NN
cord-277355-si3g5dih	145	41	)	)	-RRB-
cord-277355-si3g5dih	145	42	,	,	,
cord-277355-si3g5dih	145	43	making	make	VBG
cord-277355-si3g5dih	145	44	this	this	DT
cord-277355-si3g5dih	145	45	live	live	JJ
cord-277355-si3g5dih	145	46	virus	virus	NN
cord-277355-si3g5dih	145	47	function	function	NN
cord-277355-si3g5dih	145	48	like	like	IN
cord-277355-si3g5dih	145	49	a	a	DT
cord-277355-si3g5dih	145	50	single	single	JJ
cord-277355-si3g5dih	145	51	-	-	HYPH
cord-277355-si3g5dih	145	52	round	round	NN
cord-277355-si3g5dih	145	53	infectious	infectious	JJ
cord-277355-si3g5dih	145	54	particle	particle	NN
cord-277355-si3g5dih	145	55	(	(	-LRB-
cord-277355-si3g5dih	145	56	SRIP	SRIP	NNP
cord-277355-si3g5dih	145	57	)	)	-RRB-
cord-277355-si3g5dih	145	58	in	in	IN
cord-277355-si3g5dih	145	59	vivo	vivo	NN
cord-277355-si3g5dih	145	60	and	and	CC
cord-277355-si3g5dih	145	61	safely	safely	RB
cord-277355-si3g5dih	145	62	inducing	induce	VBG
cord-277355-si3g5dih	145	63	strong	strong	JJ
cord-277355-si3g5dih	145	64	immunity	immunity	NN
cord-277355-si3g5dih	145	65	protection	protection	NN
cord-277355-si3g5dih	145	66	against	against	IN
cord-277355-si3g5dih	145	67	vertical	vertical	JJ
cord-277355-si3g5dih	145	68	transmission	transmission	NN
cord-277355-si3g5dih	145	69	in	in	IN
cord-277355-si3g5dih	145	70	mice	mouse	NNS
cord-277355-si3g5dih	145	71	[	[	-LRB-
cord-277355-si3g5dih	145	72	33	33	CD
cord-277355-si3g5dih	145	73	]	]	-RRB-
cord-277355-si3g5dih	145	74	.	.	.
cord-277355-si3g5dih	146	1	These	these	DT
cord-277355-si3g5dih	146	2	data	datum	NNS
cord-277355-si3g5dih	146	3	indicate	indicate	VBP
cord-277355-si3g5dih	146	4	that	that	IN
cord-277355-si3g5dih	146	5	engineering	engineering	NN
cord-277355-si3g5dih	146	6	deletions	deletion	NNS
cord-277355-si3g5dih	146	7	into	into	IN
cord-277355-si3g5dih	146	8	the	the	DT
cord-277355-si3g5dih	146	9	capsid	capsid	JJ
cord-277355-si3g5dih	146	10	gene	gene	NN
cord-277355-si3g5dih	146	11	of	of	IN
cord-277355-si3g5dih	146	12	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	146	13	via	via	IN
cord-277355-si3g5dih	146	14	reverse	reverse	JJ
cord-277355-si3g5dih	146	15	genetics	genetics	NN
cord-277355-si3g5dih	146	16	is	be	VBZ
cord-277355-si3g5dih	146	17	a	a	DT
cord-277355-si3g5dih	146	18	feasible	feasible	JJ
cord-277355-si3g5dih	146	19	approach	approach	NN
cord-277355-si3g5dih	146	20	for	for	IN
cord-277355-si3g5dih	146	21	generating	generate	VBG
cord-277355-si3g5dih	146	22	efficient	efficient	JJ
cord-277355-si3g5dih	146	23	live	live	RB
cord-277355-si3g5dih	146	24	-	-	HYPH
cord-277355-si3g5dih	146	25	attenuated	attenuate	VBN
cord-277355-si3g5dih	146	26	vaccine	vaccine	NN
cord-277355-si3g5dih	146	27	candidates	candidate	NNS
cord-277355-si3g5dih	146	28	.	.	.
cord-277355-si3g5dih	147	1	The	the	DT
cord-277355-si3g5dih	147	2	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	147	3	live	live	RB
cord-277355-si3g5dih	147	4	-	-	HYPH
cord-277355-si3g5dih	147	5	attenuated	attenuate	VBN
cord-277355-si3g5dih	147	6	vaccines	vaccine	NNS
cord-277355-si3g5dih	147	7	are	be	VBP
cord-277355-si3g5dih	147	8	characterized	characterize	VBN
cord-277355-si3g5dih	147	9	by	by	IN
cord-277355-si3g5dih	147	10	their	-PRON-	PRP$
cord-277355-si3g5dih	147	11	high	high	JJ
cord-277355-si3g5dih	147	12	efficiency	efficiency	NN
cord-277355-si3g5dih	147	13	in	in	IN
cord-277355-si3g5dih	147	14	seroconversion	seroconversion	NN
cord-277355-si3g5dih	147	15	and	and	CC
cord-277355-si3g5dih	147	16	protection	protection	NN
cord-277355-si3g5dih	147	17	in	in	IN
cord-277355-si3g5dih	147	18	animals	animal	NNS
cord-277355-si3g5dih	147	19	.	.	.
cord-277355-si3g5dih	148	1	The	the	DT
cord-277355-si3g5dih	148	2	classical	classical	JJ
cord-277355-si3g5dih	148	3	live	live	RB
cord-277355-si3g5dih	148	4	-	-	HYPH
cord-277355-si3g5dih	148	5	attenuated	attenuate	VBN
cord-277355-si3g5dih	148	6	vaccines	vaccine	NNS
cord-277355-si3g5dih	148	7	were	be	VBD
cord-277355-si3g5dih	148	8	generated	generate	VBN
cord-277355-si3g5dih	148	9	by	by	IN
cord-277355-si3g5dih	148	10	continuous	continuous	JJ
cord-277355-si3g5dih	148	11	passaging	passaging	NN
cord-277355-si3g5dih	148	12	of	of	IN
cord-277355-si3g5dih	148	13	the	the	DT
cord-277355-si3g5dih	148	14	virus	virus	NN
cord-277355-si3g5dih	148	15	in	in	IN
cord-277355-si3g5dih	148	16	cell	cell	NN
cord-277355-si3g5dih	148	17	culture	culture	NN
cord-277355-si3g5dih	148	18	or	or	CC
cord-277355-si3g5dih	148	19	animal	animal	NN
cord-277355-si3g5dih	148	20	tissue	tissue	NN
cord-277355-si3g5dih	148	21	to	to	TO
cord-277355-si3g5dih	148	22	accumulate	accumulate	VB
cord-277355-si3g5dih	148	23	various	various	JJ
cord-277355-si3g5dih	148	24	mutations	mutation	NNS
cord-277355-si3g5dih	148	25	,	,	,
cord-277355-si3g5dih	148	26	finally	finally	RB
cord-277355-si3g5dih	148	27	achieving	achieve	VBG
cord-277355-si3g5dih	148	28	the	the	DT
cord-277355-si3g5dih	148	29	aim	aim	NN
cord-277355-si3g5dih	148	30	of	of	IN
cord-277355-si3g5dih	148	31	significant	significant	JJ
cord-277355-si3g5dih	148	32	attenuation	attenuation	NN
cord-277355-si3g5dih	148	33	but	but	CC
cord-277355-si3g5dih	148	34	immunogenicity	immunogenicity	NN
cord-277355-si3g5dih	148	35	in	in	IN
cord-277355-si3g5dih	148	36	vivo	vivo	NN
cord-277355-si3g5dih	148	37	.	.	.
cord-277355-si3g5dih	149	1	The	the	DT
cord-277355-si3g5dih	149	2	admirable	admirable	JJ
cord-277355-si3g5dih	149	3	example	example	NN
cord-277355-si3g5dih	149	4	is	be	VBZ
cord-277355-si3g5dih	149	5	the	the	DT
cord-277355-si3g5dih	149	6	YF-17D	YF-17D	NNP
cord-277355-si3g5dih	149	7	vaccine	vaccine	NN
cord-277355-si3g5dih	149	8	,	,	,
cord-277355-si3g5dih	149	9	which	which	WDT
cord-277355-si3g5dih	149	10	was	be	VBD
cord-277355-si3g5dih	149	11	developed	develop	VBN
cord-277355-si3g5dih	149	12	by	by	IN
cord-277355-si3g5dih	149	13	176	176	CD
cord-277355-si3g5dih	149	14	passages	passage	NNS
cord-277355-si3g5dih	149	15	of	of	IN
cord-277355-si3g5dih	149	16	the	the	DT
cord-277355-si3g5dih	149	17	Asibi	Asibi	NNP
cord-277355-si3g5dih	149	18	strain	strain	VBP
cord-277355-si3g5dih	149	19	in	in	IN
cord-277355-si3g5dih	149	20	mouse	mouse	NN
cord-277355-si3g5dih	149	21	embryo	embryo	NN
cord-277355-si3g5dih	149	22	tissue	tissue	NN
cord-277355-si3g5dih	149	23	and	and	CC
cord-277355-si3g5dih	149	24	chicken	chicken	NN
cord-277355-si3g5dih	149	25	embryo	embryo	NN
cord-277355-si3g5dih	149	26	tissue	tissue	NN
cord-277355-si3g5dih	149	27	,	,	,
cord-277355-si3g5dih	149	28	which	which	WDT
cord-277355-si3g5dih	149	29	markedly	markedly	RB
cord-277355-si3g5dih	149	30	reduced	reduce	VBD
cord-277355-si3g5dih	149	31	its	-PRON-	PRP$
cord-277355-si3g5dih	149	32	viscerotropism	viscerotropism	NN
cord-277355-si3g5dih	149	33	and	and	CC
cord-277355-si3g5dih	149	34	neurotropism	neurotropism	JJ
cord-277355-si3g5dih	149	35	[	[	-LRB-
cord-277355-si3g5dih	149	36	77	77	CD
cord-277355-si3g5dih	149	37	]	]	-RRB-
cord-277355-si3g5dih	149	38	.	.	.
cord-277355-si3g5dih	150	1	However	however	RB
cord-277355-si3g5dih	150	2	,	,	,
cord-277355-si3g5dih	150	3	this	this	DT
cord-277355-si3g5dih	150	4	traditional	traditional	JJ
cord-277355-si3g5dih	150	5	method	method	NN
cord-277355-si3g5dih	150	6	is	be	VBZ
cord-277355-si3g5dih	150	7	usually	usually	RB
cord-277355-si3g5dih	150	8	time	time	NN
cord-277355-si3g5dih	150	9	consuming	consume	VBG
cord-277355-si3g5dih	150	10	;	;	:
cord-277355-si3g5dih	150	11	it	-PRON-	PRP
cord-277355-si3g5dih	150	12	is	be	VBZ
cord-277355-si3g5dih	150	13	unpredictable	unpredictable	JJ
cord-277355-si3g5dih	150	14	whether	whether	IN
cord-277355-si3g5dih	150	15	the	the	DT
cord-277355-si3g5dih	150	16	obtained	obtain	VBN
cord-277355-si3g5dih	150	17	viruses	virus	NNS
cord-277355-si3g5dih	150	18	are	be	VBP
cord-277355-si3g5dih	150	19	attenuated	attenuated	JJ
cord-277355-si3g5dih	150	20	and	and	CC
cord-277355-si3g5dih	150	21	still	still	RB
cord-277355-si3g5dih	150	22	can	can	MD
cord-277355-si3g5dih	150	23	elicit	elicit	VB
cord-277355-si3g5dih	150	24	protective	protective	JJ
cord-277355-si3g5dih	150	25	immunity	immunity	NN
cord-277355-si3g5dih	150	26	.	.	.
cord-277355-si3g5dih	151	1	In	in	IN
cord-277355-si3g5dih	151	2	addition	addition	NN
cord-277355-si3g5dih	151	3	,	,	,
cord-277355-si3g5dih	151	4	because	because	IN
cord-277355-si3g5dih	151	5	multiple	multiple	JJ
cord-277355-si3g5dih	151	6	mutations	mutation	NNS
cord-277355-si3g5dih	151	7	spread	spread	VBN
cord-277355-si3g5dih	151	8	throughout	throughout	IN
cord-277355-si3g5dih	151	9	the	the	DT
cord-277355-si3g5dih	151	10	viral	viral	JJ
cord-277355-si3g5dih	151	11	genome	genome	NN
cord-277355-si3g5dih	151	12	,	,	,
cord-277355-si3g5dih	151	13	it	-PRON-	PRP
cord-277355-si3g5dih	151	14	is	be	VBZ
cord-277355-si3g5dih	151	15	toilsome	toilsome	JJ
cord-277355-si3g5dih	151	16	to	to	TO
cord-277355-si3g5dih	151	17	clarify	clarify	VB
cord-277355-si3g5dih	151	18	the	the	DT
cord-277355-si3g5dih	151	19	molecular	molecular	JJ
cord-277355-si3g5dih	151	20	mechanism	mechanism	NN
cord-277355-si3g5dih	151	21	responsible	responsible	JJ
cord-277355-si3g5dih	151	22	for	for	IN
cord-277355-si3g5dih	151	23	the	the	DT
cord-277355-si3g5dih	151	24	attenuated	attenuated	JJ
cord-277355-si3g5dih	151	25	phenotype	phenotype	NN
cord-277355-si3g5dih	151	26	,	,	,
cord-277355-si3g5dih	151	27	limiting	limit	VBG
cord-277355-si3g5dih	151	28	the	the	DT
cord-277355-si3g5dih	151	29	assessment	assessment	NN
cord-277355-si3g5dih	151	30	of	of	IN
cord-277355-si3g5dih	151	31	the	the	DT
cord-277355-si3g5dih	151	32	risk	risk	NN
cord-277355-si3g5dih	151	33	for	for	IN
cord-277355-si3g5dih	151	34	spontaneous	spontaneous	JJ
cord-277355-si3g5dih	151	35	reversions	reversion	NNS
cord-277355-si3g5dih	151	36	to	to	IN
cord-277355-si3g5dih	151	37	a	a	DT
cord-277355-si3g5dih	151	38	virulent	virulent	JJ
cord-277355-si3g5dih	151	39	phenotype	phenotype	NN
cord-277355-si3g5dih	151	40	.	.	.
cord-277355-si3g5dih	152	1	However	however	RB
cord-277355-si3g5dih	152	2	,	,	,
cord-277355-si3g5dih	152	3	using	use	VBG
cord-277355-si3g5dih	152	4	reverse	reverse	JJ
cord-277355-si3g5dih	152	5	genetics	genetics	NN
cord-277355-si3g5dih	152	6	tools	tool	NNS
cord-277355-si3g5dih	152	7	,	,	,
cord-277355-si3g5dih	152	8	we	-PRON-	PRP
cord-277355-si3g5dih	152	9	can	can	MD
cord-277355-si3g5dih	152	10	rationally	rationally	RB
cord-277355-si3g5dih	152	11	design	design	VB
cord-277355-si3g5dih	152	12	the	the	DT
cord-277355-si3g5dih	152	13	viral	viral	JJ
cord-277355-si3g5dih	152	14	genome	genome	NN
cord-277355-si3g5dih	152	15	to	to	TO
cord-277355-si3g5dih	152	16	obtain	obtain	VB
cord-277355-si3g5dih	152	17	a	a	DT
cord-277355-si3g5dih	152	18	desired	desire	VBN
cord-277355-si3g5dih	152	19	phenotype	phenotype	NN
cord-277355-si3g5dih	152	20	in	in	IN
cord-277355-si3g5dih	152	21	a	a	DT
cord-277355-si3g5dih	152	22	relatively	relatively	RB
cord-277355-si3g5dih	152	23	short	short	JJ
cord-277355-si3g5dih	152	24	time	time	NN
cord-277355-si3g5dih	152	25	,	,	,
cord-277355-si3g5dih	152	26	when	when	WRB
cord-277355-si3g5dih	152	27	the	the	DT
cord-277355-si3g5dih	152	28	desired	desire	VBN
cord-277355-si3g5dih	152	29	phenotype	phenotype	NN
cord-277355-si3g5dih	152	30	and	and	CC
cord-277355-si3g5dih	152	31	its	-PRON-	PRP$
cord-277355-si3g5dih	152	32	significance	significance	NN
cord-277355-si3g5dih	152	33	for	for	IN
cord-277355-si3g5dih	152	34	safety	safety	NN
cord-277355-si3g5dih	152	35	and	and	CC
cord-277355-si3g5dih	152	36	immunogenicity	immunogenicity	NN
cord-277355-si3g5dih	152	37	is	be	VBZ
cord-277355-si3g5dih	152	38	well	well	RB
cord-277355-si3g5dih	152	39	understood	understand	VBN
cord-277355-si3g5dih	152	40	,	,	,
cord-277355-si3g5dih	152	41	along	along	IN
cord-277355-si3g5dih	152	42	with	with	IN
cord-277355-si3g5dih	152	43	the	the	DT
cord-277355-si3g5dih	152	44	specific	specific	JJ
cord-277355-si3g5dih	152	45	molecular	molecular	JJ
cord-277355-si3g5dih	152	46	determinants	determinant	NNS
cord-277355-si3g5dih	152	47	behind	behind	IN
cord-277355-si3g5dih	152	48	them	-PRON-	PRP
cord-277355-si3g5dih	152	49	.	.	.
cord-277355-si3g5dih	153	1	Introducing	introduce	VBG
cord-277355-si3g5dih	153	2	deletional	deletional	JJ
cord-277355-si3g5dih	153	3	mutations	mutation	NNS
cord-277355-si3g5dih	153	4	into	into	IN
cord-277355-si3g5dih	153	5	the	the	DT
cord-277355-si3g5dih	153	6	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	153	7	capsid	capsid	NN
cord-277355-si3g5dih	153	8	gene	gene	NN
cord-277355-si3g5dih	153	9	on	on	IN
cord-277355-si3g5dih	153	10	the	the	DT
cord-277355-si3g5dih	153	11	basis	basis	NN
cord-277355-si3g5dih	153	12	of	of	IN
cord-277355-si3g5dih	153	13	a	a	DT
cord-277355-si3g5dih	153	14	well	well	RB
cord-277355-si3g5dih	153	15	-	-	HYPH
cord-277355-si3g5dih	153	16	understood	understand	VBN
cord-277355-si3g5dih	153	17	molecular	molecular	JJ
cord-277355-si3g5dih	153	18	mechanism	mechanism	NN
cord-277355-si3g5dih	153	19	is	be	VBZ
cord-277355-si3g5dih	153	20	a	a	DT
cord-277355-si3g5dih	153	21	unique	unique	JJ
cord-277355-si3g5dih	153	22	way	way	NN
cord-277355-si3g5dih	153	23	to	to	TO
cord-277355-si3g5dih	153	24	design	design	VB
cord-277355-si3g5dih	153	25	and	and	CC
cord-277355-si3g5dih	153	26	generate	generate	VB
cord-277355-si3g5dih	153	27	live	live	RB
cord-277355-si3g5dih	153	28	-	-	HYPH
cord-277355-si3g5dih	153	29	attenuated	attenuate	VBN
cord-277355-si3g5dih	153	30	vaccine	vaccine	NN
cord-277355-si3g5dih	153	31	candidates	candidate	NNS
cord-277355-si3g5dih	153	32	,	,	,
cord-277355-si3g5dih	153	33	and	and	CC
cord-277355-si3g5dih	153	34	this	this	DT
cord-277355-si3g5dih	153	35	approach	approach	NN
cord-277355-si3g5dih	153	36	has	have	VBZ
cord-277355-si3g5dih	153	37	several	several	JJ
cord-277355-si3g5dih	153	38	benefits	benefit	NNS
cord-277355-si3g5dih	153	39	.	.	.
cord-277355-si3g5dih	154	1	(	(	-LRB-
cord-277355-si3g5dih	154	2	1	1	CD
cord-277355-si3g5dih	154	3	)	)	-RRB-
cord-277355-si3g5dih	155	1	The	the	DT
cord-277355-si3g5dih	155	2	successful	successful	JJ
cord-277355-si3g5dih	155	3	application	application	NN
cord-277355-si3g5dih	155	4	of	of	IN
cord-277355-si3g5dih	155	5	this	this	DT
cord-277355-si3g5dih	155	6	approach	approach	NN
cord-277355-si3g5dih	155	7	in	in	IN
cord-277355-si3g5dih	155	8	TBEV	TBEV	NNP
cord-277355-si3g5dih	155	9	,	,	,
cord-277355-si3g5dih	155	10	DENV2	denv2	NN
cord-277355-si3g5dih	155	11	and	and	CC
cord-277355-si3g5dih	155	12	WNV	WNV	NNP
cord-277355-si3g5dih	155	13	,	,	,
cord-277355-si3g5dih	155	14	in	in	IN
cord-277355-si3g5dih	155	15	addition	addition	NN
cord-277355-si3g5dih	155	16	to	to	IN
cord-277355-si3g5dih	155	17	the	the	DT
cord-277355-si3g5dih	155	18	relatively	relatively	RB
cord-277355-si3g5dih	155	19	conserved	conserved	JJ
cord-277355-si3g5dih	155	20	structures	structure	NNS
cord-277355-si3g5dih	155	21	of	of	IN
cord-277355-si3g5dih	155	22	CPs	cp	NNS
cord-277355-si3g5dih	155	23	among	among	IN
cord-277355-si3g5dih	155	24	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	155	25	,	,	,
cord-277355-si3g5dih	155	26	suggests	suggest	VBZ
cord-277355-si3g5dih	155	27	that	that	IN
cord-277355-si3g5dih	155	28	this	this	DT
cord-277355-si3g5dih	155	29	approach	approach	NN
cord-277355-si3g5dih	155	30	can	can	MD
cord-277355-si3g5dih	155	31	be	be	VB
cord-277355-si3g5dih	155	32	a	a	DT
cord-277355-si3g5dih	155	33	universal	universal	JJ
cord-277355-si3g5dih	155	34	approach	approach	NN
cord-277355-si3g5dih	155	35	for	for	IN
cord-277355-si3g5dih	155	36	different	different	JJ
cord-277355-si3g5dih	155	37	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	155	38	,	,	,
cord-277355-si3g5dih	155	39	although	although	IN
cord-277355-si3g5dih	155	40	there	there	EX
cord-277355-si3g5dih	155	41	are	be	VBP
cord-277355-si3g5dih	155	42	possibly	possibly	RB
cord-277355-si3g5dih	155	43	intricate	intricate	JJ
cord-277355-si3g5dih	155	44	differences	difference	NNS
cord-277355-si3g5dih	155	45	in	in	IN
cord-277355-si3g5dih	155	46	the	the	DT
cord-277355-si3g5dih	155	47	length	length	NN
cord-277355-si3g5dih	155	48	and	and	CC
cord-277355-si3g5dih	155	49	location	location	NN
cord-277355-si3g5dih	155	50	of	of	IN
cord-277355-si3g5dih	155	51	deleted	delete	VBN
cord-277355-si3g5dih	155	52	mutations	mutation	NNS
cord-277355-si3g5dih	155	53	.	.	.
cord-277355-si3g5dih	156	1	(	(	-LRB-
cord-277355-si3g5dih	156	2	2	2	LS
cord-277355-si3g5dih	156	3	)	)	-RRB-
cord-277355-si3g5dih	156	4	With	with	IN
cord-277355-si3g5dih	156	5	regard	regard	NN
cord-277355-si3g5dih	156	6	to	to	IN
cord-277355-si3g5dih	156	7	safety	safety	NN
cord-277355-si3g5dih	156	8	,	,	,
cord-277355-si3g5dih	156	9	the	the	DT
cord-277355-si3g5dih	156	10	deleted	delete	VBN
cord-277355-si3g5dih	156	11	mutations	mutation	NNS
cord-277355-si3g5dih	156	12	are	be	VBP
cord-277355-si3g5dih	156	13	very	very	RB
cord-277355-si3g5dih	156	14	stable	stable	JJ
cord-277355-si3g5dih	156	15	,	,	,
cord-277355-si3g5dih	156	16	especially	especially	RB
cord-277355-si3g5dih	156	17	large	large	JJ
cord-277355-si3g5dih	156	18	deletions	deletion	NNS
cord-277355-si3g5dih	156	19	,	,	,
cord-277355-si3g5dih	156	20	and	and	CC
cord-277355-si3g5dih	156	21	it	-PRON-	PRP
cord-277355-si3g5dih	156	22	is	be	VBZ
cord-277355-si3g5dih	156	23	almost	almost	RB
cord-277355-si3g5dih	156	24	impossible	impossible	JJ
cord-277355-si3g5dih	156	25	to	to	TO
cord-277355-si3g5dih	156	26	revert	revert	VB
cord-277355-si3g5dih	156	27	to	to	IN
cord-277355-si3g5dih	156	28	a	a	DT
cord-277355-si3g5dih	156	29	wild	wild	JJ
cord-277355-si3g5dih	156	30	-	-	HYPH
cord-277355-si3g5dih	156	31	type	type	NN
cord-277355-si3g5dih	156	32	sequence	sequence	NN
cord-277355-si3g5dih	156	33	.	.	.
cord-277355-si3g5dih	157	1	Although	although	IN
cord-277355-si3g5dih	157	2	risks	risk	NNS
cord-277355-si3g5dih	157	3	can	can	MD
cord-277355-si3g5dih	157	4	arise	arise	VB
cord-277355-si3g5dih	157	5	from	from	IN
cord-277355-si3g5dih	157	6	intermolecular	intermolecular	NNP
cord-277355-si3g5dih	157	7	RNA	RNA	NNP
cord-277355-si3g5dih	157	8	recombination	recombination	NN
cord-277355-si3g5dih	157	9	events	event	NNS
cord-277355-si3g5dih	157	10	between	between	IN
cord-277355-si3g5dih	157	11	the	the	DT
cord-277355-si3g5dih	157	12	genomes	genome	NNS
cord-277355-si3g5dih	157	13	of	of	IN
cord-277355-si3g5dih	157	14	closely	closely	RB
cord-277355-si3g5dih	157	15	related	related	JJ
cord-277355-si3g5dih	157	16	viruses	virus	NNS
cord-277355-si3g5dih	157	17	,	,	,
cord-277355-si3g5dih	157	18	there	there	EX
cord-277355-si3g5dih	157	19	are	be	VBP
cord-277355-si3g5dih	157	20	few	few	JJ
cord-277355-si3g5dih	157	21	reports	report	NNS
cord-277355-si3g5dih	157	22	on	on	IN
cord-277355-si3g5dih	157	23	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	157	24	;	;	:
cord-277355-si3g5dih	157	25	thus	thus	RB
cord-277355-si3g5dih	157	26	,	,	,
cord-277355-si3g5dih	157	27	RNA	RNA	NNP
cord-277355-si3g5dih	157	28	combination	combination	NN
cord-277355-si3g5dih	157	29	is	be	VBZ
cord-277355-si3g5dih	157	30	not	not	RB
cord-277355-si3g5dih	157	31	a	a	DT
cord-277355-si3g5dih	157	32	major	major	JJ
cord-277355-si3g5dih	157	33	risk	risk	NN
cord-277355-si3g5dih	157	34	because	because	IN
cord-277355-si3g5dih	157	35	of	of	IN
cord-277355-si3g5dih	157	36	the	the	DT
cord-277355-si3g5dih	157	37	very	very	RB
cord-277355-si3g5dih	157	38	low	low	JJ
cord-277355-si3g5dih	157	39	frequency	frequency	NN
cord-277355-si3g5dih	157	40	[	[	-LRB-
cord-277355-si3g5dih	157	41	78	78	CD
cord-277355-si3g5dih	157	42	]	]	-RRB-
cord-277355-si3g5dih	157	43	.	.	.
cord-277355-si3g5dih	158	1	In	in	IN
cord-277355-si3g5dih	158	2	addition	addition	NN
cord-277355-si3g5dih	158	3	,	,	,
cord-277355-si3g5dih	158	4	CP	cp	NN
cord-277355-si3g5dih	158	5	deletions	deletion	NNS
cord-277355-si3g5dih	158	6	in	in	IN
cord-277355-si3g5dih	158	7	combination	combination	NN
cord-277355-si3g5dih	158	8	with	with	IN
cord-277355-si3g5dih	158	9	other	other	JJ
cord-277355-si3g5dih	158	10	well	well	RB
cord-277355-si3g5dih	158	11	-	-	HYPH
cord-277355-si3g5dih	158	12	understood	understand	VBN
cord-277355-si3g5dih	158	13	mutations	mutation	NNS
cord-277355-si3g5dih	158	14	,	,	,
cord-277355-si3g5dih	158	15	such	such	JJ
cord-277355-si3g5dih	158	16	as	as	IN
cord-277355-si3g5dih	158	17	point	point	NN
cord-277355-si3g5dih	158	18	mutations	mutation	NNS
cord-277355-si3g5dih	158	19	in	in	IN
cord-277355-si3g5dih	158	20	the	the	DT
cord-277355-si3g5dih	158	21	E	e	NN
cord-277355-si3g5dih	158	22	protein	protein	NN
cord-277355-si3g5dih	158	23	and	and	CC
cord-277355-si3g5dih	158	24	other	other	JJ
cord-277355-si3g5dih	158	25	different	different	JJ
cord-277355-si3g5dih	158	26	principles	principle	NNS
cord-277355-si3g5dih	158	27	,	,	,
cord-277355-si3g5dih	158	28	further	further	RB
cord-277355-si3g5dih	158	29	improve	improve	VB
cord-277355-si3g5dih	158	30	the	the	DT
cord-277355-si3g5dih	158	31	safety	safety	NN
cord-277355-si3g5dih	158	32	[	[	-LRB-
cord-277355-si3g5dih	158	33	19	19	CD
cord-277355-si3g5dih	158	34	,	,	,
cord-277355-si3g5dih	158	35	76	76	CD
cord-277355-si3g5dih	158	36	]	]	-RRB-
cord-277355-si3g5dih	158	37	.	.	.
cord-277355-si3g5dih	159	1	(	(	-LRB-
cord-277355-si3g5dih	159	2	3	3	LS
cord-277355-si3g5dih	159	3	)	)	-RRB-
cord-277355-si3g5dih	159	4	C	c	NN
cord-277355-si3g5dih	159	5	-	-	HYPH
cord-277355-si3g5dih	159	6	deleted	delete	VBN
cord-277355-si3g5dih	159	7	viruses	virus	NNS
cord-277355-si3g5dih	159	8	contain	contain	VBP
cord-277355-si3g5dih	159	9	authentic	authentic	JJ
cord-277355-si3g5dih	159	10	structural	structural	JJ
cord-277355-si3g5dih	159	11	proteins	protein	NNS
cord-277355-si3g5dih	159	12	(	(	-LRB-
cord-277355-si3g5dih	159	13	prM	prm	JJ
cord-277355-si3g5dih	159	14	/	/	SYM
cord-277355-si3g5dih	159	15	E	e	NN
cord-277355-si3g5dih	159	16	)	)	-RRB-
cord-277355-si3g5dih	159	17	and	and	CC
cord-277355-si3g5dih	159	18	nonstructural	nonstructural	JJ
cord-277355-si3g5dih	159	19	proteins	protein	NNS
cord-277355-si3g5dih	159	20	,	,	,
cord-277355-si3g5dih	159	21	so	so	IN
cord-277355-si3g5dih	159	22	they	-PRON-	PRP
cord-277355-si3g5dih	159	23	induce	induce	VBP
cord-277355-si3g5dih	159	24	only	only	RB
cord-277355-si3g5dih	159	25	specific	specific	JJ
cord-277355-si3g5dih	159	26	immune	immune	JJ
cord-277355-si3g5dih	159	27	responses	response	NNS
cord-277355-si3g5dih	159	28	,	,	,
cord-277355-si3g5dih	159	29	which	which	WDT
cord-277355-si3g5dih	159	30	should	should	MD
cord-277355-si3g5dih	159	31	be	be	VB
cord-277355-si3g5dih	159	32	considered	consider	VBN
cord-277355-si3g5dih	159	33	more	more	RBR
cord-277355-si3g5dih	159	34	advantageous	advantageous	JJ
cord-277355-si3g5dih	159	35	than	than	IN
cord-277355-si3g5dih	159	36	chimeric	chimeric	JJ
cord-277355-si3g5dih	159	37	viruses	virus	NNS
cord-277355-si3g5dih	159	38	[	[	-LRB-
cord-277355-si3g5dih	159	39	19	19	CD
cord-277355-si3g5dih	159	40	,	,	,
cord-277355-si3g5dih	159	41	33	33	CD
cord-277355-si3g5dih	159	42	]	]	-RRB-
cord-277355-si3g5dih	159	43	.	.	.
cord-277355-si3g5dih	160	1	In	in	IN
cord-277355-si3g5dih	160	2	addition	addition	NN
cord-277355-si3g5dih	160	3	,	,	,
cord-277355-si3g5dih	160	4	C	c	NN
cord-277355-si3g5dih	160	5	-	-	HYPH
cord-277355-si3g5dih	160	6	deleted	delete	VBN
cord-277355-si3g5dih	160	7	viruses	virus	NNS
cord-277355-si3g5dih	160	8	are	be	VBP
cord-277355-si3g5dih	160	9	highly	highly	RB
cord-277355-si3g5dih	160	10	immunogenic	immunogenic	JJ
cord-277355-si3g5dih	160	11	,	,	,
cord-277355-si3g5dih	160	12	which	which	WDT
cord-277355-si3g5dih	160	13	is	be	VBZ
cord-277355-si3g5dih	160	14	a	a	DT
cord-277355-si3g5dih	160	15	general	general	JJ
cord-277355-si3g5dih	160	16	advantage	advantage	NN
cord-277355-si3g5dih	160	17	of	of	IN
cord-277355-si3g5dih	160	18	live	live	JJ
cord-277355-si3g5dih	160	19	vaccines	vaccine	NNS
cord-277355-si3g5dih	160	20	;	;	:
cord-277355-si3g5dih	160	21	with	with	IN
cord-277355-si3g5dih	160	22	only	only	RB
cord-277355-si3g5dih	160	23	a	a	DT
cord-277355-si3g5dih	160	24	single	single	JJ
cord-277355-si3g5dih	160	25	-	-	HYPH
cord-277355-si3g5dih	160	26	dose	dose	NN
cord-277355-si3g5dih	160	27	vaccination	vaccination	NN
cord-277355-si3g5dih	160	28	,	,	,
cord-277355-si3g5dih	160	29	protective	protective	JJ
cord-277355-si3g5dih	160	30	immunity	immunity	NN
cord-277355-si3g5dih	160	31	can	can	MD
cord-277355-si3g5dih	160	32	be	be	VB
cord-277355-si3g5dih	160	33	elicited	elicit	VBN
cord-277355-si3g5dih	160	34	[	[	-LRB-
cord-277355-si3g5dih	160	35	9	9	CD
cord-277355-si3g5dih	160	36	,	,	,
cord-277355-si3g5dih	160	37	76	76	CD
cord-277355-si3g5dih	160	38	]	]	-RRB-
cord-277355-si3g5dih	160	39	.	.	.
cord-277355-si3g5dih	161	1	In	in	IN
cord-277355-si3g5dih	161	2	summary	summary	NN
cord-277355-si3g5dih	161	3	,	,	,
cord-277355-si3g5dih	161	4	introducing	introduce	VBG
cord-277355-si3g5dih	161	5	deletions	deletion	NNS
cord-277355-si3g5dih	161	6	into	into	IN
cord-277355-si3g5dih	161	7	the	the	DT
cord-277355-si3g5dih	161	8	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	161	9	capsid	capsid	NN
cord-277355-si3g5dih	161	10	gene	gene	NN
cord-277355-si3g5dih	161	11	is	be	VBZ
cord-277355-si3g5dih	161	12	a	a	DT
cord-277355-si3g5dih	161	13	promising	promising	JJ
cord-277355-si3g5dih	161	14	approach	approach	NN
cord-277355-si3g5dih	161	15	for	for	IN
cord-277355-si3g5dih	161	16	novel	novel	NNP
cord-277355-si3g5dih	161	17	flaviviral	flaviviral	NNP
cord-277355-si3g5dih	161	18	live	live	RB
cord-277355-si3g5dih	161	19	-	-	HYPH
cord-277355-si3g5dih	161	20	attenuated	attenuate	VBN
cord-277355-si3g5dih	161	21	vaccine	vaccine	NN
cord-277355-si3g5dih	161	22	development	development	NN
cord-277355-si3g5dih	161	23	(	(	-LRB-
cord-277355-si3g5dih	161	24	Summarized	summarize	VBN
cord-277355-si3g5dih	161	25	in	in	IN
cord-277355-si3g5dih	161	26	Table	Table	NNP
cord-277355-si3g5dih	161	27	1	1	CD
cord-277355-si3g5dih	161	28	)	)	-RRB-
cord-277355-si3g5dih	161	29	.	.	.
cord-277355-si3g5dih	162	1	Although	although	IN
cord-277355-si3g5dih	162	2	live	live	JJ
cord-277355-si3g5dih	162	3	vaccines	vaccine	NNS
cord-277355-si3g5dih	162	4	are	be	VBP
cord-277355-si3g5dih	162	5	highly	highly	RB
cord-277355-si3g5dih	162	6	efficacious	efficacious	JJ
cord-277355-si3g5dih	162	7	,	,	,
cord-277355-si3g5dih	162	8	there	there	EX
cord-277355-si3g5dih	162	9	are	be	VBP
cord-277355-si3g5dih	162	10	still	still	RB
cord-277355-si3g5dih	162	11	risks	risk	NNS
cord-277355-si3g5dih	162	12	of	of	IN
cord-277355-si3g5dih	162	13	rare	rare	JJ
cord-277355-si3g5dih	162	14	vaccine	vaccine	NN
cord-277355-si3g5dih	162	15	-	-	HYPH
cord-277355-si3g5dih	162	16	associated	associate	VBN
cord-277355-si3g5dih	162	17	diseases	disease	NNS
cord-277355-si3g5dih	162	18	,	,	,
cord-277355-si3g5dih	162	19	especially	especially	RB
cord-277355-si3g5dih	162	20	in	in	IN
cord-277355-si3g5dih	162	21	immunodeficient	immunodeficient	JJ
cord-277355-si3g5dih	162	22	individuals	individual	NNS
cord-277355-si3g5dih	162	23	.	.	.
cord-277355-si3g5dih	163	1	To	to	TO
cord-277355-si3g5dih	163	2	address	address	VB
cord-277355-si3g5dih	163	3	this	this	DT
cord-277355-si3g5dih	163	4	issue	issue	NN
cord-277355-si3g5dih	163	5	,	,	,
cord-277355-si3g5dih	163	6	limiting	limit	VBG
cord-277355-si3g5dih	163	7	the	the	DT
cord-277355-si3g5dih	163	8	infectivity	infectivity	NN
cord-277355-si3g5dih	163	9	of	of	IN
cord-277355-si3g5dih	163	10	a	a	DT
cord-277355-si3g5dih	163	11	vaccine	vaccine	NN
cord-277355-si3g5dih	163	12	by	by	IN
cord-277355-si3g5dih	163	13	disabling	disable	VBG
cord-277355-si3g5dih	163	14	its	-PRON-	PRP$
cord-277355-si3g5dih	163	15	viral	viral	JJ
cord-277355-si3g5dih	163	16	encapsidation	encapsidation	NN
cord-277355-si3g5dih	163	17	process	process	NN
cord-277355-si3g5dih	163	18	is	be	VBZ
cord-277355-si3g5dih	163	19	an	an	DT
cord-277355-si3g5dih	163	20	elegant	elegant	JJ
cord-277355-si3g5dih	163	21	solution	solution	NN
cord-277355-si3g5dih	163	22	.	.	.
cord-277355-si3g5dih	164	1	This	this	DT
cord-277355-si3g5dih	164	2	goal	goal	NN
cord-277355-si3g5dih	164	3	can	can	MD
cord-277355-si3g5dih	164	4	be	be	VB
cord-277355-si3g5dih	164	5	easily	easily	RB
cord-277355-si3g5dih	164	6	achieved	achieve	VBN
cord-277355-si3g5dih	164	7	by	by	IN
cord-277355-si3g5dih	164	8	introducing	introduce	VBG
cord-277355-si3g5dih	164	9	very	very	RB
cord-277355-si3g5dih	164	10	large	large	JJ
cord-277355-si3g5dih	164	11	internal	internal	JJ
cord-277355-si3g5dih	164	12	deletions	deletion	NNS
cord-277355-si3g5dih	164	13	into	into	IN
cord-277355-si3g5dih	164	14	CP	CP	NNP
cord-277355-si3g5dih	164	15	to	to	TO
cord-277355-si3g5dih	164	16	generate	generate	VB
cord-277355-si3g5dih	164	17	noninfectious	noninfectious	JJ
cord-277355-si3g5dih	164	18	DC	DC	NNP
cord-277355-si3g5dih	164	19	-	-	HYPH
cord-277355-si3g5dih	164	20	replicons	replicon	NNS
cord-277355-si3g5dih	164	21	,	,	,
cord-277355-si3g5dih	164	22	therefore	therefore	RB
cord-277355-si3g5dih	164	23	opening	open	VBG
cord-277355-si3g5dih	164	24	a	a	DT
cord-277355-si3g5dih	164	25	new	new	JJ
cord-277355-si3g5dih	164	26	approach	approach	NN
cord-277355-si3g5dih	164	27	for	for	IN
cord-277355-si3g5dih	164	28	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	164	29	vaccines	vaccine	NNS
cord-277355-si3g5dih	164	30	.	.	.
cord-277355-si3g5dih	165	1	A	a	DT
cord-277355-si3g5dih	165	2	selfamplifying	selfamplifye	VBG
cord-277355-si3g5dih	165	3	DC	DC	NNP
cord-277355-si3g5dih	165	4	-	-	HYPH
cord-277355-si3g5dih	165	5	replicon	replicon	NNP
cord-277355-si3g5dih	165	6	that	that	WDT
cord-277355-si3g5dih	165	7	is	be	VBZ
cord-277355-si3g5dih	165	8	able	able	JJ
cord-277355-si3g5dih	165	9	to	to	TO
cord-277355-si3g5dih	165	10	produce	produce	VB
cord-277355-si3g5dih	165	11	highly	highly	RB
cord-277355-si3g5dih	165	12	immunogenic	immunogenic	JJ
cord-277355-si3g5dih	165	13	SVPs	svp	NNS
cord-277355-si3g5dih	165	14	may	may	MD
cord-277355-si3g5dih	165	15	be	be	VB
cord-277355-si3g5dih	165	16	delivered	deliver	VBN
cord-277355-si3g5dih	165	17	as	as	IN
cord-277355-si3g5dih	165	18	RNA	RNA	NNP
cord-277355-si3g5dih	165	19	,	,	,
cord-277355-si3g5dih	165	20	DNA	DNA	NNP
cord-277355-si3g5dih	165	21	,	,	,
cord-277355-si3g5dih	165	22	or	or	CC
cord-277355-si3g5dih	165	23	virus	virus	NN
cord-277355-si3g5dih	165	24	-	-	HYPH
cord-277355-si3g5dih	165	25	like	like	JJ
cord-277355-si3g5dih	165	26	particles	particle	NNS
cord-277355-si3g5dih	165	27	(	(	-LRB-
cord-277355-si3g5dih	165	28	VLPs	vlp	NNS
cord-277355-si3g5dih	165	29	)	)	-RRB-
cord-277355-si3g5dih	165	30	[	[	-LRB-
cord-277355-si3g5dih	165	31	79	79	CD
cord-277355-si3g5dih	165	32	]	]	-RRB-
cord-277355-si3g5dih	165	33	.	.	.
cord-277355-si3g5dih	166	1	As	as	IN
cord-277355-si3g5dih	166	2	a	a	DT
cord-277355-si3g5dih	166	3	proof	proof	NN
cord-277355-si3g5dih	166	4	of	of	IN
cord-277355-si3g5dih	166	5	concept	concept	NN
cord-277355-si3g5dih	166	6	,	,	,
cord-277355-si3g5dih	166	7	this	this	DT
cord-277355-si3g5dih	166	8	approach	approach	NN
cord-277355-si3g5dih	166	9	was	be	VBD
cord-277355-si3g5dih	166	10	first	first	RB
cord-277355-si3g5dih	166	11	verified	verify	VBN
cord-277355-si3g5dih	166	12	with	with	IN
cord-277355-si3g5dih	166	13	TBEV	TBEV	NNP
cord-277355-si3g5dih	166	14	[	[	-LRB-
cord-277355-si3g5dih	166	15	21	21	CD
cord-277355-si3g5dih	166	16	]	]	-RRB-
cord-277355-si3g5dih	166	17	.	.	.
cord-277355-si3g5dih	167	1	A	a	DT
cord-277355-si3g5dih	167	2	62-residue	62-residue	CD
cord-277355-si3g5dih	167	3	deletion	deletion	NN
cord-277355-si3g5dih	167	4	in	in	IN
cord-277355-si3g5dih	167	5	TBEV	TBEV	NNP
cord-277355-si3g5dih	167	6	CP	CP	NNP
cord-277355-si3g5dih	167	7	(	(	-LRB-
cord-277355-si3g5dih	167	8	D28	D28	NNP
cord-277355-si3g5dih	167	9	-	-	HYPH
cord-277355-si3g5dih	167	10	89	89	NNP
cord-277355-si3g5dih	167	11	)	)	-RRB-
cord-277355-si3g5dih	167	12	irreversibly	irreversibly	RB
cord-277355-si3g5dih	167	13	abolished	abolish	VBD
cord-277355-si3g5dih	167	14	infectious	infectious	JJ
cord-277355-si3g5dih	167	15	virion	virion	NN
cord-277355-si3g5dih	167	16	formation	formation	NN
cord-277355-si3g5dih	167	17	but	but	CC
cord-277355-si3g5dih	167	18	maintained	maintain	VBD
cord-277355-si3g5dih	167	19	RNA	RNA	NNP
cord-277355-si3g5dih	167	20	replication	replication	NN
cord-277355-si3g5dih	167	21	and	and	CC
cord-277355-si3g5dih	167	22	promoted	promote	VBN
cord-277355-si3g5dih	167	23	SVP	SVP	NNP
cord-277355-si3g5dih	167	24	production	production	NN
cord-277355-si3g5dih	167	25	.	.	.
cord-277355-si3g5dih	168	1	By	by	IN
cord-277355-si3g5dih	168	2	engineering	engineer	VBG
cord-277355-si3g5dih	168	3	supplementary	supplementary	JJ
cord-277355-si3g5dih	168	4	mutations	mutation	NNS
cord-277355-si3g5dih	168	5	that	that	WDT
cord-277355-si3g5dih	168	6	uncouple	uncouple	VBP
cord-277355-si3g5dih	168	7	the	the	DT
cord-277355-si3g5dih	168	8	coordinated	coordinated	JJ
cord-277355-si3g5dih	168	9	cleavage	cleavage	NN
cord-277355-si3g5dih	168	10	events	event	NNS
cord-277355-si3g5dih	168	11	in	in	IN
cord-277355-si3g5dih	168	12	the	the	DT
cord-277355-si3g5dih	168	13	C	C	NNP
cord-277355-si3g5dih	168	14	-	-	HYPH
cord-277355-si3g5dih	168	15	prM	prm	JJ
cord-277355-si3g5dih	168	16	junction	junction	NN
cord-277355-si3g5dih	168	17	(	(	-LRB-
cord-277355-si3g5dih	168	18	see	see	VB
cord-277355-si3g5dih	168	19	previous	previous	JJ
cord-277355-si3g5dih	168	20	section	section	NN
cord-277355-si3g5dih	168	21	)	)	-RRB-
cord-277355-si3g5dih	168	22	,	,	,
cord-277355-si3g5dih	168	23	an	an	DT
cord-277355-si3g5dih	168	24	idealized	idealized	JJ
cord-277355-si3g5dih	168	25	mutant	mutant	JJ
cord-277355-si3g5dih	168	26	C	c	NN
cord-277355-si3g5dih	168	27	(	(	-LRB-
cord-277355-si3g5dih	168	28	D28	D28	NNP
cord-277355-si3g5dih	168	29	-	-	HYPH
cord-277355-si3g5dih	168	30	89)-S	89)-S	NNP
cord-277355-si3g5dih	168	31	that	that	WDT
cord-277355-si3g5dih	168	32	liberates	liberate	VBZ
cord-277355-si3g5dih	168	33	significantly	significantly	RB
cord-277355-si3g5dih	168	34	more	more	JJR
cord-277355-si3g5dih	168	35	SVPs	svp	NNS
cord-277355-si3g5dih	168	36	was	be	VBD
cord-277355-si3g5dih	168	37	created	create	VBN
cord-277355-si3g5dih	168	38	.	.	.
cord-277355-si3g5dih	169	1	Mouse	mouse	NN
cord-277355-si3g5dih	169	2	experiments	experiment	NNS
cord-277355-si3g5dih	169	3	showed	show	VBD
cord-277355-si3g5dih	169	4	that	that	IN
cord-277355-si3g5dih	169	5	this	this	DT
cord-277355-si3g5dih	169	6	replicon	replicon	NN
cord-277355-si3g5dih	169	7	mRNA	mRNA	NNP
cord-277355-si3g5dih	169	8	vaccine	vaccine	NN
cord-277355-si3g5dih	169	9	(	(	-LRB-
cord-277355-si3g5dih	169	10	delivered	deliver	VBN
cord-277355-si3g5dih	169	11	by	by	IN
cord-277355-si3g5dih	169	12	a	a	DT
cord-277355-si3g5dih	169	13	gene	gene	NN
cord-277355-si3g5dih	169	14	gun	gun	NN
cord-277355-si3g5dih	169	15	)	)	-RRB-
cord-277355-si3g5dih	169	16	induced	induce	VBD
cord-277355-si3g5dih	169	17	a	a	DT
cord-277355-si3g5dih	169	18	broad	broad	JJ
cord-277355-si3g5dih	169	19	humoral	humoral	JJ
cord-277355-si3g5dih	169	20	and	and	CC
cord-277355-si3g5dih	169	21	cellular	cellular	JJ
cord-277355-si3g5dih	169	22	immune	immune	JJ
cord-277355-si3g5dih	169	23	response	response	NN
cord-277355-si3g5dih	169	24	comparable	comparable	JJ
cord-277355-si3g5dih	169	25	to	to	IN
cord-277355-si3g5dih	169	26	that	that	DT
cord-277355-si3g5dih	169	27	of	of	IN
cord-277355-si3g5dih	169	28	a	a	DT
cord-277355-si3g5dih	169	29	live	live	JJ
cord-277355-si3g5dih	169	30	vaccine	vaccine	NN
cord-277355-si3g5dih	169	31	and	and	CC
cord-277355-si3g5dih	169	32	protected	protect	VBN
cord-277355-si3g5dih	169	33	mice	mouse	NNS
cord-277355-si3g5dih	169	34	from	from	IN
cord-277355-si3g5dih	169	35	challenge	challenge	NN
cord-277355-si3g5dih	169	36	;	;	:
cord-277355-si3g5dih	169	37	even	even	RB
cord-277355-si3g5dih	169	38	a	a	DT
cord-277355-si3g5dih	169	39	single	single	JJ
cord-277355-si3g5dih	169	40	immunization	immunization	NN
cord-277355-si3g5dih	169	41	induced	induce	VBN
cord-277355-si3g5dih	169	42	long	long	RB
cord-277355-si3g5dih	169	43	-	-	HYPH
cord-277355-si3g5dih	169	44	lasting	last	VBG
cord-277355-si3g5dih	169	45	(	(	-LRB-
cord-277355-si3g5dih	169	46	more	more	JJR
cord-277355-si3g5dih	169	47	than	than	IN
cord-277355-si3g5dih	169	48	1	1	CD
cord-277355-si3g5dih	169	49	year	year	NN
cord-277355-si3g5dih	169	50	)	)	-RRB-
cord-277355-si3g5dih	169	51	and	and	CC
cord-277355-si3g5dih	169	52	high	high	JJ
cord-277355-si3g5dih	169	53	titers	titer	NNS
cord-277355-si3g5dih	169	54	of	of	IN
cord-277355-si3g5dih	169	55	neutralizing	neutralize	VBG
cord-277355-si3g5dih	169	56	antibodies	antibody	NNS
cord-277355-si3g5dih	169	57	[	[	-LRB-
cord-277355-si3g5dih	169	58	80	80	CD
cord-277355-si3g5dih	169	59	]	]	-RRB-
cord-277355-si3g5dih	169	60	.	.	.
cord-277355-si3g5dih	170	1	Then	then	RB
cord-277355-si3g5dih	170	2	,	,	,
cord-277355-si3g5dih	170	3	a	a	DT
cord-277355-si3g5dih	170	4	DNA	dna	NN
cord-277355-si3g5dih	170	5	-	-	HYPH
cord-277355-si3g5dih	170	6	based	base	VBN
cord-277355-si3g5dih	170	7	noninfectious	noninfectious	JJ
cord-277355-si3g5dih	170	8	DC	DC	NNP
cord-277355-si3g5dih	170	9	replicon	replicon	NN
cord-277355-si3g5dih	170	10	for	for	IN
cord-277355-si3g5dih	170	11	WNV	WNV	NNP
cord-277355-si3g5dih	170	12	was	be	VBD
cord-277355-si3g5dih	170	13	also	also	RB
cord-277355-si3g5dih	170	14	tested	test	VBN
cord-277355-si3g5dih	170	15	in	in	IN
cord-277355-si3g5dih	170	16	mice	mouse	NNS
cord-277355-si3g5dih	170	17	,	,	,
cord-277355-si3g5dih	170	18	and	and	CC
cord-277355-si3g5dih	170	19	it	-PRON-	PRP
cord-277355-si3g5dih	170	20	induced	induce	VBD
cord-277355-si3g5dih	170	21	a	a	DT
cord-277355-si3g5dih	170	22	high	high	JJ
cord-277355-si3g5dih	170	23	-	-	HYPH
cord-277355-si3g5dih	170	24	quality	quality	NN
cord-277355-si3g5dih	170	25	immune	immune	JJ
cord-277355-si3g5dih	170	26	response	response	NN
cord-277355-si3g5dih	170	27	by	by	IN
cord-277355-si3g5dih	170	28	intramuscular	intramuscular	JJ
cord-277355-si3g5dih	170	29	injection	injection	NN
cord-277355-si3g5dih	170	30	and	and	CC
cord-277355-si3g5dih	170	31	effective	effective	JJ
cord-277355-si3g5dih	170	32	protection	protection	NN
cord-277355-si3g5dih	170	33	of	of	IN
cord-277355-si3g5dih	170	34	animals	animal	NNS
cord-277355-si3g5dih	170	35	,	,	,
cord-277355-si3g5dih	170	36	similar	similar	JJ
cord-277355-si3g5dih	170	37	to	to	IN
cord-277355-si3g5dih	170	38	those	those	DT
cord-277355-si3g5dih	170	39	of	of	IN
cord-277355-si3g5dih	170	40	the	the	DT
cord-277355-si3g5dih	170	41	virus	virus	NN
cord-277355-si3g5dih	170	42	or	or	CC
cord-277355-si3g5dih	170	43	infectious	infectious	JJ
cord-277355-si3g5dih	170	44	DNA	dna	NN
cord-277355-si3g5dih	170	45	,	,	,
cord-277355-si3g5dih	170	46	while	while	IN
cord-277355-si3g5dih	170	47	the	the	DT
cord-277355-si3g5dih	170	48	magnitude	magnitude	NN
cord-277355-si3g5dih	170	49	was	be	VBD
cord-277355-si3g5dih	170	50	relatively	relatively	RB
cord-277355-si3g5dih	170	51	lower	low	JJR
cord-277355-si3g5dih	170	52	[	[	-LRB-
cord-277355-si3g5dih	170	53	81	81	CD
cord-277355-si3g5dih	170	54	]	]	-RRB-
cord-277355-si3g5dih	170	55	.	.	.
cord-277355-si3g5dih	171	1	Therefore	therefore	RB
cord-277355-si3g5dih	171	2	,	,	,
cord-277355-si3g5dih	171	3	these	these	DT
cord-277355-si3g5dih	171	4	studies	study	NNS
cord-277355-si3g5dih	171	5	demonstrated	demonstrate	VBD
cord-277355-si3g5dih	171	6	the	the	DT
cord-277355-si3g5dih	171	7	enormous	enormous	JJ
cord-277355-si3g5dih	171	8	potential	potential	NN
cord-277355-si3g5dih	171	9	of	of	IN
cord-277355-si3g5dih	171	10	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	171	11	DC	DC	NNP
cord-277355-si3g5dih	171	12	replicons	replicon	NNS
cord-277355-si3g5dih	171	13	as	as	IN
cord-277355-si3g5dih	171	14	a	a	DT
cord-277355-si3g5dih	171	15	new	new	JJ
cord-277355-si3g5dih	171	16	type	type	NN
cord-277355-si3g5dih	171	17	of	of	IN
cord-277355-si3g5dih	171	18	nucleic	nucleic	JJ
cord-277355-si3g5dih	171	19	acid	acid	NN
cord-277355-si3g5dih	171	20	vaccine	vaccine	NN
cord-277355-si3g5dih	171	21	.	.	.
cord-277355-si3g5dih	172	1	Nevertheless	nevertheless	RB
cord-277355-si3g5dih	172	2	,	,	,
cord-277355-si3g5dih	172	3	in	in	IN
cord-277355-si3g5dih	172	4	the	the	DT
cord-277355-si3g5dih	172	5	early	early	JJ
cord-277355-si3g5dih	172	6	study	study	NN
cord-277355-si3g5dih	172	7	of	of	IN
cord-277355-si3g5dih	172	8	nucleic	nucleic	JJ
cord-277355-si3g5dih	172	9	acid	acid	NN
cord-277355-si3g5dih	172	10	vaccines	vaccine	NNS
cord-277355-si3g5dih	172	11	,	,	,
cord-277355-si3g5dih	172	12	booster	booster	NN
cord-277355-si3g5dih	172	13	immunizations	immunization	NNS
cord-277355-si3g5dih	172	14	are	be	VBP
cord-277355-si3g5dih	172	15	often	often	RB
cord-277355-si3g5dih	172	16	necessary	necessary	JJ
cord-277355-si3g5dih	172	17	for	for	IN
cord-277355-si3g5dih	172	18	providing	provide	VBG
cord-277355-si3g5dih	172	19	sufficient	sufficient	JJ
cord-277355-si3g5dih	172	20	protection	protection	NN
cord-277355-si3g5dih	172	21	against	against	IN
cord-277355-si3g5dih	172	22	virulent	virulent	JJ
cord-277355-si3g5dih	172	23	strain	strain	NN
cord-277355-si3g5dih	172	24	challenges	challenge	NNS
cord-277355-si3g5dih	172	25	due	due	JJ
cord-277355-si3g5dih	172	26	to	to	IN
cord-277355-si3g5dih	172	27	the	the	DT
cord-277355-si3g5dih	172	28	low	low	JJ
cord-277355-si3g5dih	172	29	delivery	delivery	NN
cord-277355-si3g5dih	172	30	efficiency	efficiency	NN
cord-277355-si3g5dih	172	31	of	of	IN
cord-277355-si3g5dih	172	32	DNA	DNA	NNP
cord-277355-si3g5dih	172	33	and	and	CC
cord-277355-si3g5dih	172	34	RNA	RNA	NNP
cord-277355-si3g5dih	172	35	in	in	IN
cord-277355-si3g5dih	172	36	vivo	vivo	NNP
cord-277355-si3g5dih	172	37	.	.	.
cord-277355-si3g5dih	173	1	To	to	TO
cord-277355-si3g5dih	173	2	overcome	overcome	VB
cord-277355-si3g5dih	173	3	this	this	DT
cord-277355-si3g5dih	173	4	barrier	barrier	NN
cord-277355-si3g5dih	173	5	,	,	,
cord-277355-si3g5dih	173	6	one	one	CD
cord-277355-si3g5dih	173	7	advisable	advisable	JJ
cord-277355-si3g5dih	173	8	alternative	alternative	NN
cord-277355-si3g5dih	173	9	is	be	VBZ
cord-277355-si3g5dih	173	10	viral	viral	JJ
cord-277355-si3g5dih	173	11	delivery	delivery	NN
cord-277355-si3g5dih	173	12	,	,	,
cord-277355-si3g5dih	173	13	which	which	WDT
cord-277355-si3g5dih	173	14	delivers	deliver	VBZ
cord-277355-si3g5dih	173	15	replicon	replicon	NNP
cord-277355-si3g5dih	173	16	RNA	RNA	NNP
cord-277355-si3g5dih	173	17	via	via	IN
cord-277355-si3g5dih	173	18	VLPs	vlp	NNS
cord-277355-si3g5dih	173	19	[	[	-LRB-
cord-277355-si3g5dih	173	20	79	79	CD
cord-277355-si3g5dih	173	21	]	]	-RRB-
cord-277355-si3g5dih	173	22	.	.	.
cord-277355-si3g5dih	174	1	The	the	DT
cord-277355-si3g5dih	174	2	DC	DC	NNP
cord-277355-si3g5dih	174	3	replicon	replicon	NN
cord-277355-si3g5dih	174	4	RNA	RNA	NNP
cord-277355-si3g5dih	174	5	can	can	MD
cord-277355-si3g5dih	174	6	be	be	VB
cord-277355-si3g5dih	174	7	packaged	package	VBN
cord-277355-si3g5dih	174	8	into	into	IN
cord-277355-si3g5dih	174	9	VLPs	vlp	NNS
cord-277355-si3g5dih	174	10	by	by	IN
cord-277355-si3g5dih	174	11	trans	trans	NNP
cord-277355-si3g5dih	174	12	-	-	JJ
cord-277355-si3g5dih	174	13	complemented	complement	VBN
cord-277355-si3g5dih	174	14	CPs	cp	NNS
cord-277355-si3g5dih	174	15	to	to	TO
cord-277355-si3g5dih	174	16	form	form	VB
cord-277355-si3g5dih	174	17	SRIPs	srip	NNS
cord-277355-si3g5dih	174	18	(	(	-LRB-
cord-277355-si3g5dih	174	19	or	or	CC
cord-277355-si3g5dih	174	20	pseudoviruses	pseudoviruse	NNS
cord-277355-si3g5dih	174	21	)	)	-RRB-
cord-277355-si3g5dih	174	22	.	.	.
cord-277355-si3g5dih	175	1	True	true	JJ
cord-277355-si3g5dih	175	2	to	to	IN
cord-277355-si3g5dih	175	3	the	the	DT
cord-277355-si3g5dih	175	4	SRIP	SRIP	NNP
cord-277355-si3g5dih	175	5	name	name	NN
cord-277355-si3g5dih	175	6	,	,	,
cord-277355-si3g5dih	175	7	these	these	DT
cord-277355-si3g5dih	175	8	particles	particle	NNS
cord-277355-si3g5dih	175	9	can	can	MD
cord-277355-si3g5dih	175	10	invade	invade	VB
cord-277355-si3g5dih	175	11	cells	cell	NNS
cord-277355-si3g5dih	175	12	and	and	CC
cord-277355-si3g5dih	175	13	release	release	VB
cord-277355-si3g5dih	175	14	the	the	DT
cord-277355-si3g5dih	175	15	replicon	replicon	NNP
cord-277355-si3g5dih	175	16	RNA	RNA	NNP
cord-277355-si3g5dih	175	17	to	to	IN
cord-277355-si3g5dih	175	18	the	the	DT
cord-277355-si3g5dih	175	19	cytoplasm	cytoplasm	NN
cord-277355-si3g5dih	175	20	,	,	,
cord-277355-si3g5dih	175	21	followed	follow	VBN
cord-277355-si3g5dih	175	22	by	by	IN
cord-277355-si3g5dih	175	23	initial	initial	JJ
cord-277355-si3g5dih	175	24	RNA	RNA	NNP
cord-277355-si3g5dih	175	25	replication	replication	NN
cord-277355-si3g5dih	175	26	but	but	CC
cord-277355-si3g5dih	175	27	inability	inability	NN
cord-277355-si3g5dih	175	28	to	to	TO
cord-277355-si3g5dih	175	29	form	form	VB
cord-277355-si3g5dih	175	30	infectious	infectious	JJ
cord-277355-si3g5dih	175	31	virions	virion	NNS
cord-277355-si3g5dih	175	32	because	because	IN
cord-277355-si3g5dih	175	33	of	of	IN
cord-277355-si3g5dih	175	34	the	the	DT
cord-277355-si3g5dih	175	35	lack	lack	NN
cord-277355-si3g5dih	175	36	of	of	IN
cord-277355-si3g5dih	175	37	a	a	DT
cord-277355-si3g5dih	175	38	functional	functional	JJ
cord-277355-si3g5dih	175	39	copy	copy	NN
cord-277355-si3g5dih	175	40	of	of	IN
cord-277355-si3g5dih	175	41	the	the	DT
cord-277355-si3g5dih	175	42	structural	structural	JJ
cord-277355-si3g5dih	175	43	gene	gene	NN
cord-277355-si3g5dih	175	44	in	in	IN
cord-277355-si3g5dih	175	45	the	the	DT
cord-277355-si3g5dih	175	46	genome	genome	NN
cord-277355-si3g5dih	175	47	[	[	-LRB-
cord-277355-si3g5dih	175	48	82	82	CD
cord-277355-si3g5dih	175	49	]	]	-RRB-
cord-277355-si3g5dih	175	50	[	[	-LRB-
cord-277355-si3g5dih	175	51	83	83	CD
cord-277355-si3g5dih	175	52	]	]	-RRB-
cord-277355-si3g5dih	175	53	[	[	-LRB-
cord-277355-si3g5dih	175	54	84	84	CD
cord-277355-si3g5dih	175	55	]	]	-RRB-
cord-277355-si3g5dih	175	56	;	;	:
cord-277355-si3g5dih	175	57	however	however	RB
cord-277355-si3g5dih	175	58	,	,	,
cord-277355-si3g5dih	175	59	the	the	DT
cord-277355-si3g5dih	175	60	cells	cell	NNS
cord-277355-si3g5dih	175	61	infected	infect	VBN
cord-277355-si3g5dih	175	62	by	by	IN
cord-277355-si3g5dih	175	63	SRIP	SRIP	NNP
cord-277355-si3g5dih	175	64	-	-	HYPH
cord-277355-si3g5dih	175	65	packaged	package	VBN
cord-277355-si3g5dih	175	66	DC	DC	NNP
cord-277355-si3g5dih	175	67	replicon	replicon	NN
cord-277355-si3g5dih	175	68	RNA	RNA	NNP
cord-277355-si3g5dih	175	69	should	should	MD
cord-277355-si3g5dih	175	70	produce	produce	VB
cord-277355-si3g5dih	175	71	a	a	DT
cord-277355-si3g5dih	175	72	mass	mass	NN
cord-277355-si3g5dih	175	73	of	of	IN
cord-277355-si3g5dih	175	74	SVPs	svp	NNS
cord-277355-si3g5dih	175	75	.	.	.
cord-277355-si3g5dih	176	1	To	to	IN
cord-277355-si3g5dih	176	2	date	date	NN
cord-277355-si3g5dih	176	3	,	,	,
cord-277355-si3g5dih	176	4	different	different	JJ
cord-277355-si3g5dih	176	5	expression	expression	NN
cord-277355-si3g5dih	176	6	systems	system	NNS
cord-277355-si3g5dih	176	7	have	have	VBP
cord-277355-si3g5dih	176	8	been	be	VBN
cord-277355-si3g5dih	176	9	used	use	VBN
cord-277355-si3g5dih	176	10	to	to	TO
cord-277355-si3g5dih	176	11	package	package	VB
cord-277355-si3g5dih	176	12	the	the	DT
cord-277355-si3g5dih	176	13	DC	DC	NNP
cord-277355-si3g5dih	176	14	replicons	replicon	NNS
cord-277355-si3g5dih	176	15	of	of	IN
cord-277355-si3g5dih	176	16	WNV	WNV	NNP
cord-277355-si3g5dih	176	17	[	[	-LRB-
cord-277355-si3g5dih	176	18	85	85	CD
cord-277355-si3g5dih	176	19	]	]	-RRB-
cord-277355-si3g5dih	176	20	,	,	,
cord-277355-si3g5dih	176	21	YFV	YFV	NNP
cord-277355-si3g5dih	176	22	[	[	-LRB-
cord-277355-si3g5dih	176	23	86	86	CD
cord-277355-si3g5dih	176	24	]	]	-RRB-
cord-277355-si3g5dih	176	25	and	and	CC
cord-277355-si3g5dih	176	26	DENV2	denv2	NN
cord-277355-si3g5dih	176	27	[	[	-LRB-
cord-277355-si3g5dih	176	28	87	87	CD
cord-277355-si3g5dih	176	29	,	,	,
cord-277355-si3g5dih	176	30	88	88	CD
cord-277355-si3g5dih	176	31	]	]	-RRB-
cord-277355-si3g5dih	176	32	to	to	TO
cord-277355-si3g5dih	176	33	produce	produce	VB
cord-277355-si3g5dih	176	34	SRIPs	srip	NNS
cord-277355-si3g5dih	176	35	.	.	.
cord-277355-si3g5dih	177	1	The	the	DT
cord-277355-si3g5dih	177	2	viral	viral	JJ
cord-277355-si3g5dih	177	3	delivery	delivery	NN
cord-277355-si3g5dih	177	4	approach	approach	NN
cord-277355-si3g5dih	177	5	of	of	IN
cord-277355-si3g5dih	177	6	the	the	DT
cord-277355-si3g5dih	177	7	DC	DC	NNP
cord-277355-si3g5dih	177	8	-	-	HYPH
cord-277355-si3g5dih	177	9	replicon	replicon	NNP
cord-277355-si3g5dih	177	10	was	be	VBD
cord-277355-si3g5dih	177	11	first	first	RB
cord-277355-si3g5dih	177	12	applied	apply	VBN
cord-277355-si3g5dih	177	13	for	for	IN
cord-277355-si3g5dih	177	14	YFV	YFV	NNP
cord-277355-si3g5dih	177	15	and	and	CC
cord-277355-si3g5dih	177	16	WNV	WNV	NNP
cord-277355-si3g5dih	177	17	[	[	-LRB-
cord-277355-si3g5dih	177	18	32	32	CD
cord-277355-si3g5dih	177	19	]	]	-RRB-
cord-277355-si3g5dih	177	20	,	,	,
cord-277355-si3g5dih	177	21	the	the	DT
cord-277355-si3g5dih	177	22	DC	DC	NNP
cord-277355-si3g5dih	177	23	-	-	HYPH
cord-277355-si3g5dih	177	24	replicons	replicon	NNS
cord-277355-si3g5dih	177	25	can	can	MD
cord-277355-si3g5dih	177	26	be	be	VB
cord-277355-si3g5dih	177	27	easily	easily	RB
cord-277355-si3g5dih	177	28	packaged	package	VBN
cord-277355-si3g5dih	177	29	into	into	IN
cord-277355-si3g5dih	177	30	VLPs	vlp	NNS
cord-277355-si3g5dih	177	31	,	,	,
cord-277355-si3g5dih	177	32	and	and	CC
cord-277355-si3g5dih	177	33	the	the	DT
cord-277355-si3g5dih	177	34	titer	titer	NN
cord-277355-si3g5dih	177	35	reached	reach	VBD
cord-277355-si3g5dih	177	36	approximately	approximately	RB
cord-277355-si3g5dih	177	37	10	10	CD
cord-277355-si3g5dih	177	38	8	8	CD
cord-277355-si3g5dih	177	39	SRIPs	srip	NNS
cord-277355-si3g5dih	177	40	/	/	SYM
cord-277355-si3g5dih	177	41	ml	ml	NN
cord-277355-si3g5dih	177	42	[	[	-LRB-
cord-277355-si3g5dih	177	43	32	32	CD
cord-277355-si3g5dih	177	44	]	]	-RRB-
cord-277355-si3g5dih	177	45	.	.	.
cord-277355-si3g5dih	178	1	A	a	DT
cord-277355-si3g5dih	178	2	single	single	JJ
cord-277355-si3g5dih	178	3	-	-	HYPH
cord-277355-si3g5dih	178	4	dose	dose	NN
cord-277355-si3g5dih	178	5	intraperitoneal	intraperitoneal	JJ
cord-277355-si3g5dih	178	6	immunization	immunization	NN
cord-277355-si3g5dih	178	7	of	of	IN
cord-277355-si3g5dih	178	8	mice	mouse	NNS
cord-277355-si3g5dih	178	9	with	with	IN
cord-277355-si3g5dih	179	1	3	3	CD
cord-277355-si3g5dih	179	2	Â	â	CD
cord-277355-si3g5dih	179	3	10	10	CD
cord-277355-si3g5dih	179	4	4	4	CD
cord-277355-si3g5dih	179	5	WNV	WNV	NNP
cord-277355-si3g5dih	179	6	SRIPs	srip	NNS
cord-277355-si3g5dih	179	7	completely	completely	RB
cord-277355-si3g5dih	179	8	protected	protect	VBD
cord-277355-si3g5dih	179	9	the	the	DT
cord-277355-si3g5dih	179	10	mice	mouse	NNS
cord-277355-si3g5dih	179	11	from	from	IN
cord-277355-si3g5dih	179	12	a	a	DT
cord-277355-si3g5dih	179	13	lethal	lethal	JJ
cord-277355-si3g5dih	179	14	challenge	challenge	NN
cord-277355-si3g5dih	179	15	with	with	IN
cord-277355-si3g5dih	179	16	a	a	DT
cord-277355-si3g5dih	179	17	virulent	virulent	JJ
cord-277355-si3g5dih	179	18	WNV	WNV	NNP
cord-277355-si3g5dih	179	19	strain	strain	NN
cord-277355-si3g5dih	179	20	[	[	-LRB-
cord-277355-si3g5dih	179	21	32	32	CD
cord-277355-si3g5dih	179	22	]	]	-RRB-
cord-277355-si3g5dih	179	23	.	.	.
cord-277355-si3g5dih	180	1	In	in	IN
cord-277355-si3g5dih	180	2	a	a	DT
cord-277355-si3g5dih	180	3	subsequent	subsequent	JJ
cord-277355-si3g5dih	180	4	study	study	NN
cord-277355-si3g5dih	180	5	,	,	,
cord-277355-si3g5dih	180	6	a	a	DT
cord-277355-si3g5dih	180	7	more	more	RBR
cord-277355-si3g5dih	180	8	efficient	efficient	JJ
cord-277355-si3g5dih	180	9	and	and	CC
cord-277355-si3g5dih	180	10	safer	safe	JJR
cord-277355-si3g5dih	180	11	cultivation	cultivation	NN
cord-277355-si3g5dih	180	12	system	system	NN
cord-277355-si3g5dih	180	13	was	be	VBD
cord-277355-si3g5dih	180	14	developed	develop	VBN
cord-277355-si3g5dih	180	15	for	for	IN
cord-277355-si3g5dih	180	16	the	the	DT
cord-277355-si3g5dih	180	17	production	production	NN
cord-277355-si3g5dih	180	18	of	of	IN
cord-277355-si3g5dih	180	19	second	second	JJ
cord-277355-si3g5dih	180	20	-	-	HYPH
cord-277355-si3g5dih	180	21	generation	generation	NN
cord-277355-si3g5dih	180	22	WNV	WNV	NNP
cord-277355-si3g5dih	180	23	SRIPs	srip	NNS
cord-277355-si3g5dih	180	24	,	,	,
cord-277355-si3g5dih	180	25	which	which	WDT
cord-277355-si3g5dih	180	26	was	be	VBD
cord-277355-si3g5dih	180	27	named	name	VBN
cord-277355-si3g5dih	180	28	RepliVAX	RepliVAX	NNP
cord-277355-si3g5dih	181	1	WN	WN	NNP
cord-277355-si3g5dih	181	2	[	[	-LRB-
cord-277355-si3g5dih	181	3	85	85	CD
cord-277355-si3g5dih	181	4	]	]	-RRB-
cord-277355-si3g5dih	181	5	.	.	.
cord-277355-si3g5dih	182	1	Single	single	JJ
cord-277355-si3g5dih	182	2	immunization	immunization	NN
cord-277355-si3g5dih	182	3	with	with	IN
cord-277355-si3g5dih	182	4	RepliVAX	RepliVAX	NNP
cord-277355-si3g5dih	183	1	WN	WN	NNP
cord-277355-si3g5dih	183	2	elicited	elicit	VBD
cord-277355-si3g5dih	183	3	strong	strong	JJ
cord-277355-si3g5dih	183	4	protective	protective	JJ
cord-277355-si3g5dih	183	5	immunity	immunity	NN
cord-277355-si3g5dih	183	6	against	against	IN
cord-277355-si3g5dih	183	7	WNV	WNV	NNP
cord-277355-si3g5dih	183	8	disease	disease	NN
cord-277355-si3g5dih	183	9	in	in	IN
cord-277355-si3g5dih	183	10	mice	mouse	NNS
cord-277355-si3g5dih	183	11	and	and	CC
cord-277355-si3g5dih	183	12	hamsters	hamster	NNS
cord-277355-si3g5dih	183	13	,	,	,
cord-277355-si3g5dih	183	14	and	and	CC
cord-277355-si3g5dih	183	15	durable	durable	JJ
cord-277355-si3g5dih	183	16	protective	protective	JJ
cord-277355-si3g5dih	183	17	immunity	immunity	NN
cord-277355-si3g5dih	183	18	in	in	IN
cord-277355-si3g5dih	183	19	hamsters	hamster	NNS
cord-277355-si3g5dih	183	20	lasted	last	VBD
cord-277355-si3g5dih	183	21	for	for	IN
cord-277355-si3g5dih	183	22	6	6	CD
cord-277355-si3g5dih	183	23	months	month	NNS
cord-277355-si3g5dih	183	24	[	[	-LRB-
cord-277355-si3g5dih	183	25	85	85	CD
cord-277355-si3g5dih	183	26	,	,	,
cord-277355-si3g5dih	183	27	89	89	CD
cord-277355-si3g5dih	183	28	]	]	-RRB-
cord-277355-si3g5dih	183	29	;	;	:
cord-277355-si3g5dih	183	30	in	in	IN
cord-277355-si3g5dih	183	31	mice	mouse	NNS
cord-277355-si3g5dih	183	32	,	,	,
cord-277355-si3g5dih	183	33	WNV	WNV	NNP
cord-277355-si3g5dih	183	34	-	-	HYPH
cord-277355-si3g5dih	183	35	specific	specific	JJ
cord-277355-si3g5dih	183	36	IgG	IgG	NNP
cord-277355-si3g5dih	183	37	antibody	antibody	NN
cord-277355-si3g5dih	183	38	responses	response	NNS
cord-277355-si3g5dih	183	39	and	and	CC
cord-277355-si3g5dih	183	40	vigorous	vigorous	JJ
cord-277355-si3g5dih	183	41	and	and	CC
cord-277355-si3g5dih	183	42	specific	specific	JJ
cord-277355-si3g5dih	183	43	CD4	CD4	NNP
cord-277355-si3g5dih	183	44	+	+	CC
cord-277355-si3g5dih	183	45	and	and	CC
cord-277355-si3g5dih	183	46	CD8	CD8	NNP
cord-277355-si3g5dih	183	47	+	+	CC
cord-277355-si3g5dih	183	48	T	T	NNP
cord-277355-si3g5dih	183	49	cell	cell	NN
cord-277355-si3g5dih	183	50	responses	response	NNS
cord-277355-si3g5dih	183	51	were	be	VBD
cord-277355-si3g5dih	183	52	detected	detect	VBN
cord-277355-si3g5dih	183	53	after	after	IN
cord-277355-si3g5dih	183	54	immunization	immunization	NN
cord-277355-si3g5dih	183	55	and	and	CC
cord-277355-si3g5dih	183	56	induced	induce	VBN
cord-277355-si3g5dih	183	57	a	a	DT
cord-277355-si3g5dih	183	58	Th1biased	th1biase	VBN
cord-277355-si3g5dih	183	59	immune	immune	JJ
cord-277355-si3g5dih	183	60	response	response	NN
cord-277355-si3g5dih	183	61	,	,	,
cord-277355-si3g5dih	183	62	similar	similar	JJ
cord-277355-si3g5dih	183	63	to	to	IN
cord-277355-si3g5dih	183	64	live	live	VB
cord-277355-si3g5dih	183	65	-	-	HYPH
cord-277355-si3g5dih	183	66	attenuated	attenuate	VBN
cord-277355-si3g5dih	183	67	vaccines	vaccine	NNS
cord-277355-si3g5dih	183	68	and	and	CC
cord-277355-si3g5dih	183	69	different	different	JJ
cord-277355-si3g5dih	183	70	from	from	IN
cord-277355-si3g5dih	183	71	inactivated	inactivate	VBN
cord-277355-si3g5dih	183	72	vaccines	vaccine	NNS
cord-277355-si3g5dih	183	73	[	[	-LRB-
cord-277355-si3g5dih	183	74	90	90	CD
cord-277355-si3g5dih	183	75	,	,	,
cord-277355-si3g5dih	183	76	91	91	CD
cord-277355-si3g5dih	183	77	]	]	-RRB-
cord-277355-si3g5dih	183	78	;	;	:
cord-277355-si3g5dih	183	79	importantly	importantly	RB
cord-277355-si3g5dih	183	80	,	,	,
cord-277355-si3g5dih	183	81	longlived	longlived	JJ
cord-277355-si3g5dih	183	82	plasma	plasma	NN
cord-277355-si3g5dih	183	83	cells	cell	NNS
cord-277355-si3g5dih	183	84	secreting	secrete	VBG
cord-277355-si3g5dih	183	85	WNV	WNV	NNP
cord-277355-si3g5dih	183	86	-	-	HYPH
cord-277355-si3g5dih	183	87	specific	specific	JJ
cord-277355-si3g5dih	183	88	IgG	igg	NN
cord-277355-si3g5dih	183	89	antibodies	antibody	NNS
cord-277355-si3g5dih	183	90	and	and	CC
cord-277355-si3g5dih	183	91	CD8	CD8	NNP
cord-277355-si3g5dih	183	92	+	+	CC
cord-277355-si3g5dih	183	93	memory	memory	NN
cord-277355-si3g5dih	183	94	T	T	NNP
cord-277355-si3g5dih	183	95	cell	cell	NN
cord-277355-si3g5dih	183	96	responses	response	NNS
cord-277355-si3g5dih	183	97	were	be	VBD
cord-277355-si3g5dih	183	98	detected	detect	VBN
cord-277355-si3g5dih	183	99	at	at	IN
cord-277355-si3g5dih	183	100	8	8	CD
cord-277355-si3g5dih	183	101	months	month	NNS
cord-277355-si3g5dih	183	102	post	post	NN
cord-277355-si3g5dih	183	103	immunization	immunization	NN
cord-277355-si3g5dih	183	104	[	[	-LRB-
cord-277355-si3g5dih	183	105	92	92	CD
cord-277355-si3g5dih	183	106	]	]	-RRB-
cord-277355-si3g5dih	183	107	.	.	.
cord-277355-si3g5dih	184	1	Furthermore	furthermore	RB
cord-277355-si3g5dih	184	2	,	,	,
cord-277355-si3g5dih	184	3	in	in	IN
cord-277355-si3g5dih	184	4	comparison	comparison	NN
cord-277355-si3g5dih	184	5	with	with	IN
cord-277355-si3g5dih	184	6	that	that	DT
cord-277355-si3g5dih	184	7	of	of	IN
cord-277355-si3g5dih	184	8	liveattenuated	liveattenuated	JJ
cord-277355-si3g5dih	184	9	vaccines	vaccine	NNS
cord-277355-si3g5dih	184	10	and	and	CC
cord-277355-si3g5dih	184	11	inactivated	inactivate	VBN
cord-277355-si3g5dih	184	12	vaccines	vaccine	NNS
cord-277355-si3g5dih	184	13	in	in	IN
cord-277355-si3g5dih	184	14	mice	mouse	NNS
cord-277355-si3g5dih	184	15	and	and	CC
cord-277355-si3g5dih	184	16	hamsters	hamster	NNS
cord-277355-si3g5dih	184	17	,	,	,
cord-277355-si3g5dih	184	18	the	the	DT
cord-277355-si3g5dih	184	19	immunogenicity	immunogenicity	NN
cord-277355-si3g5dih	184	20	of	of	IN
cord-277355-si3g5dih	184	21	RepliVax	RepliVax	NNP
cord-277355-si3g5dih	184	22	vaccines	vaccine	NNS
cord-277355-si3g5dih	184	23	(	(	-LRB-
cord-277355-si3g5dih	184	24	for	for	IN
cord-277355-si3g5dih	184	25	WNV	WNV	NNP
cord-277355-si3g5dih	184	26	and	and	CC
cord-277355-si3g5dih	184	27	YFV	YFV	NNP
cord-277355-si3g5dih	184	28	)	)	-RRB-
cord-277355-si3g5dih	184	29	was	be	VBD
cord-277355-si3g5dih	184	30	comparable	comparable	JJ
cord-277355-si3g5dih	184	31	in	in	IN
cord-277355-si3g5dih	184	32	terms	term	NNS
cord-277355-si3g5dih	184	33	of	of	IN
cord-277355-si3g5dih	184	34	both	both	CC
cord-277355-si3g5dih	184	35	the	the	DT
cord-277355-si3g5dih	184	36	magnitude	magnitude	NN
cord-277355-si3g5dih	184	37	and	and	CC
cord-277355-si3g5dih	184	38	durability	durability	NN
cord-277355-si3g5dih	184	39	of	of	IN
cord-277355-si3g5dih	184	40	the	the	DT
cord-277355-si3g5dih	184	41	response	response	NN
cord-277355-si3g5dih	184	42	[	[	-LRB-
cord-277355-si3g5dih	184	43	90	90	CD
cord-277355-si3g5dih	184	44	]	]	-RRB-
cord-277355-si3g5dih	184	45	.	.	.
cord-277355-si3g5dih	185	1	Based	base	VBN
cord-277355-si3g5dih	185	2	on	on	IN
cord-277355-si3g5dih	185	3	the	the	DT
cord-277355-si3g5dih	185	4	RepliVax	RepliVax	NNP
cord-277355-si3g5dih	185	5	pseudoviruses	pseudoviruse	NNS
cord-277355-si3g5dih	185	6	,	,	,
cord-277355-si3g5dih	185	7	different	different	JJ
cord-277355-si3g5dih	185	8	single	single	JJ
cord-277355-si3g5dih	185	9	-	-	HYPH
cord-277355-si3g5dih	185	10	cycle	cycle	NN
cord-277355-si3g5dih	185	11	chimeric	chimeric	JJ
cord-277355-si3g5dih	185	12	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	185	13	vaccines	vaccine	NNS
cord-277355-si3g5dih	185	14	were	be	VBD
cord-277355-si3g5dih	185	15	generated	generate	VBN
cord-277355-si3g5dih	185	16	for	for	IN
cord-277355-si3g5dih	185	17	JEV	JEV	NNP
cord-277355-si3g5dih	185	18	,	,	,
cord-277355-si3g5dih	185	19	DENV2	denv2	NN
cord-277355-si3g5dih	185	20	,	,	,
cord-277355-si3g5dih	185	21	and	and	CC
cord-277355-si3g5dih	185	22	TBV	TBV	NNP
cord-277355-si3g5dih	185	23	by	by	IN
cord-277355-si3g5dih	185	24	replacing	replace	VBG
cord-277355-si3g5dih	185	25	the	the	DT
cord-277355-si3g5dih	185	26	native	native	JJ
cord-277355-si3g5dih	185	27	prM	prm	JJ
cord-277355-si3g5dih	185	28	-	-	HYPH
cord-277355-si3g5dih	185	29	E	e	NN
cord-277355-si3g5dih	185	30	genes	gene	NNS
cord-277355-si3g5dih	185	31	of	of	IN
cord-277355-si3g5dih	185	32	Cdeleted	Cdeleted	NNP
cord-277355-si3g5dih	185	33	replicons	replicon	NNS
cord-277355-si3g5dih	185	34	with	with	IN
cord-277355-si3g5dih	185	35	those	those	DT
cord-277355-si3g5dih	185	36	of	of	IN
cord-277355-si3g5dih	185	37	other	other	JJ
cord-277355-si3g5dih	185	38	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	185	39	[	[	-LRB-
cord-277355-si3g5dih	185	40	90	90	CD
cord-277355-si3g5dih	185	41	,	,	,
cord-277355-si3g5dih	185	42	[	[	-LRB-
cord-277355-si3g5dih	185	43	93	93	CD
cord-277355-si3g5dih	185	44	]	]	-RRB-
cord-277355-si3g5dih	185	45	[	[	-LRB-
cord-277355-si3g5dih	185	46	94	94	CD
cord-277355-si3g5dih	185	47	]	]	-RRB-
cord-277355-si3g5dih	185	48	[	[	-LRB-
cord-277355-si3g5dih	185	49	95	95	CD
cord-277355-si3g5dih	185	50	]	]	-RRB-
cord-277355-si3g5dih	185	51	[	[	-LRB-
cord-277355-si3g5dih	185	52	96	96	CD
cord-277355-si3g5dih	185	53	]	]	-RRB-
cord-277355-si3g5dih	185	54	.	.	.
cord-277355-si3g5dih	186	1	All	all	DT
cord-277355-si3g5dih	186	2	of	of	IN
cord-277355-si3g5dih	186	3	these	these	DT
cord-277355-si3g5dih	186	4	constructs	construct	NNS
cord-277355-si3g5dih	186	5	revealed	reveal	VBD
cord-277355-si3g5dih	186	6	good	good	JJ
cord-277355-si3g5dih	186	7	capacity	capacity	NN
cord-277355-si3g5dih	186	8	to	to	TO
cord-277355-si3g5dih	186	9	induce	induce	VB
cord-277355-si3g5dih	186	10	a	a	DT
cord-277355-si3g5dih	186	11	potent	potent	JJ
cord-277355-si3g5dih	186	12	and	and	CC
cord-277355-si3g5dih	186	13	durable	durable	JJ
cord-277355-si3g5dih	186	14	immune	immune	JJ
cord-277355-si3g5dih	186	15	response	response	NN
cord-277355-si3g5dih	186	16	in	in	IN
cord-277355-si3g5dih	186	17	animal	animal	NN
cord-277355-si3g5dih	186	18	models	model	NNS
cord-277355-si3g5dih	186	19	,	,	,
cord-277355-si3g5dih	186	20	and	and	CC
cord-277355-si3g5dih	186	21	it	-PRON-	PRP
cord-277355-si3g5dih	186	22	is	be	VBZ
cord-277355-si3g5dih	186	23	important	important	JJ
cord-277355-si3g5dih	186	24	that	that	IN
cord-277355-si3g5dih	186	25	their	-PRON-	PRP$
cord-277355-si3g5dih	186	26	immunogenicity	immunogenicity	NN
cord-277355-si3g5dih	186	27	was	be	VBD
cord-277355-si3g5dih	186	28	not	not	RB
cord-277355-si3g5dih	186	29	significantly	significantly	RB
cord-277355-si3g5dih	186	30	affected	affect	VBN
cord-277355-si3g5dih	186	31	by	by	IN
cord-277355-si3g5dih	186	32	preexisting	preexist	VBG
cord-277355-si3g5dih	186	33	immunity	immunity	NN
cord-277355-si3g5dih	186	34	against	against	IN
cord-277355-si3g5dih	186	35	the	the	DT
cord-277355-si3g5dih	186	36	vector	vector	NN
cord-277355-si3g5dih	186	37	backbone	backbone	NN
cord-277355-si3g5dih	186	38	[	[	-LRB-
cord-277355-si3g5dih	186	39	80	80	CD
cord-277355-si3g5dih	186	40	,	,	,
cord-277355-si3g5dih	186	41	96	96	CD
cord-277355-si3g5dih	186	42	]	]	-RRB-
cord-277355-si3g5dih	186	43	.	.	.
cord-277355-si3g5dih	187	1	There	there	EX
cord-277355-si3g5dih	187	2	is	be	VBZ
cord-277355-si3g5dih	187	3	also	also	RB
cord-277355-si3g5dih	187	4	an	an	DT
cord-277355-si3g5dih	187	5	investigation	investigation	NN
cord-277355-si3g5dih	187	6	of	of	IN
cord-277355-si3g5dih	187	7	an	an	DT
cord-277355-si3g5dih	187	8	SRIP	SRIP	NNP
cord-277355-si3g5dih	187	9	-	-	HYPH
cord-277355-si3g5dih	187	10	producing	produce	VBG
cord-277355-si3g5dih	187	11	DNA	dna	NN
cord-277355-si3g5dih	187	12	vaccine	vaccine	NN
cord-277355-si3g5dih	187	13	.	.	.
cord-277355-si3g5dih	188	1	This	this	DT
cord-277355-si3g5dih	188	2	vaccine	vaccine	NN
cord-277355-si3g5dih	188	3	is	be	VBZ
cord-277355-si3g5dih	188	4	based	base	VBN
cord-277355-si3g5dih	188	5	on	on	IN
cord-277355-si3g5dih	188	6	a	a	DT
cord-277355-si3g5dih	188	7	C(D18	c(d18	NN
cord-277355-si3g5dih	188	8	-	-	HYPH
cord-277355-si3g5dih	188	9	100	100	CD
cord-277355-si3g5dih	188	10	)	)	-RRB-
cord-277355-si3g5dih	188	11	replicon	replicon	NNP
cord-277355-si3g5dih	188	12	cDNA	cdna	NN
cord-277355-si3g5dih	188	13	of	of	IN
cord-277355-si3g5dih	188	14	KUNV	KUNV	NNPS
cord-277355-si3g5dih	188	15	,	,	,
cord-277355-si3g5dih	188	16	and	and	CC
cord-277355-si3g5dih	188	17	a	a	DT
cord-277355-si3g5dih	188	18	separate	separate	JJ
cord-277355-si3g5dih	188	19	but	but	CC
cord-277355-si3g5dih	188	20	complete	complete	JJ
cord-277355-si3g5dih	188	21	CP	cp	NN
cord-277355-si3g5dih	188	22	is	be	VBZ
cord-277355-si3g5dih	188	23	encoded	encode	VBN
cord-277355-si3g5dih	188	24	in	in	IN
cord-277355-si3g5dih	188	25	reverse	reverse	JJ
cord-277355-si3g5dih	188	26	orientation	orientation	NN
cord-277355-si3g5dih	188	27	controlled	control	VBN
cord-277355-si3g5dih	188	28	by	by	IN
cord-277355-si3g5dih	188	29	a	a	DT
cord-277355-si3g5dih	188	30	second	second	JJ
cord-277355-si3g5dih	188	31	cytomegalovirus	cytomegalovirus	NN
cord-277355-si3g5dih	188	32	(	(	-LRB-
cord-277355-si3g5dih	188	33	CMV	CMV	NNP
cord-277355-si3g5dih	188	34	)	)	-RRB-
cord-277355-si3g5dih	188	35	promoter	promoter	NN
cord-277355-si3g5dih	188	36	in	in	IN
cord-277355-si3g5dih	188	37	the	the	DT
cord-277355-si3g5dih	188	38	same	same	JJ
cord-277355-si3g5dih	188	39	plasmid	plasmid	NN
cord-277355-si3g5dih	188	40	.	.	.
cord-277355-si3g5dih	189	1	After	after	IN
cord-277355-si3g5dih	189	2	transfection	transfection	NN
cord-277355-si3g5dih	189	3	,	,	,
cord-277355-si3g5dih	189	4	both	both	CC
cord-277355-si3g5dih	189	5	the	the	DT
cord-277355-si3g5dih	189	6	replicon	replicon	NNP
cord-277355-si3g5dih	189	7	RNA	RNA	NNP
cord-277355-si3g5dih	189	8	and	and	CC
cord-277355-si3g5dih	189	9	CP	CP	NNP
cord-277355-si3g5dih	189	10	are	be	VBP
cord-277355-si3g5dih	189	11	produced	produce	VBN
cord-277355-si3g5dih	189	12	in	in	IN
cord-277355-si3g5dih	189	13	the	the	DT
cord-277355-si3g5dih	189	14	cell	cell	NN
cord-277355-si3g5dih	189	15	,	,	,
cord-277355-si3g5dih	189	16	therefore	therefore	RB
cord-277355-si3g5dih	189	17	forming	form	VBG
cord-277355-si3g5dih	189	18	secreted	secrete	VBN
cord-277355-si3g5dih	189	19	SRIPs	srip	NNS
cord-277355-si3g5dih	189	20	that	that	WDT
cord-277355-si3g5dih	189	21	deliver	deliver	VBP
cord-277355-si3g5dih	189	22	the	the	DT
cord-277355-si3g5dih	189	23	DC	DC	NNP
cord-277355-si3g5dih	189	24	replicon	replicon	NN
cord-277355-si3g5dih	189	25	to	to	IN
cord-277355-si3g5dih	189	26	adjacent	adjacent	JJ
cord-277355-si3g5dih	189	27	cells	cell	NNS
cord-277355-si3g5dih	189	28	,	,	,
cord-277355-si3g5dih	189	29	and	and	CC
cord-277355-si3g5dih	189	30	both	both	DT
cord-277355-si3g5dih	189	31	DNA	dna	NN
cord-277355-si3g5dih	189	32	-	-	HYPH
cord-277355-si3g5dih	189	33	transfected	transfecte	VBN
cord-277355-si3g5dih	189	34	and	and	CC
cord-277355-si3g5dih	189	35	SRIP	SRIP	NNP
cord-277355-si3g5dih	189	36	-	-	HYPH
cord-277355-si3g5dih	189	37	infected	infect	VBN
cord-277355-si3g5dih	189	38	cells	cell	NNS
cord-277355-si3g5dih	189	39	contain	contain	VBP
cord-277355-si3g5dih	189	40	the	the	DT
cord-277355-si3g5dih	189	41	DC	DC	NNP
cord-277355-si3g5dih	189	42	replicon	replicon	NN
cord-277355-si3g5dih	189	43	,	,	,
cord-277355-si3g5dih	189	44	which	which	WDT
cord-277355-si3g5dih	189	45	produces	produce	VBZ
cord-277355-si3g5dih	189	46	SVPs	svp	NNS
cord-277355-si3g5dih	189	47	,	,	,
cord-277355-si3g5dih	189	48	resulting	result	VBG
cord-277355-si3g5dih	189	49	in	in	IN
cord-277355-si3g5dih	189	50	an	an	DT
cord-277355-si3g5dih	189	51	enhanced	enhanced	JJ
cord-277355-si3g5dih	189	52	immune	immune	JJ
cord-277355-si3g5dih	189	53	response	response	NN
cord-277355-si3g5dih	189	54	[	[	-LRB-
cord-277355-si3g5dih	189	55	31	31	CD
cord-277355-si3g5dih	189	56	,	,	,
cord-277355-si3g5dih	189	57	97	97	CD
cord-277355-si3g5dih	189	58	]	]	-RRB-
cord-277355-si3g5dih	189	59	.	.	.
cord-277355-si3g5dih	190	1	Both	both	DT
cord-277355-si3g5dih	190	2	DC	DC	NNP
cord-277355-si3g5dih	190	3	replicon	replicon	NN
cord-277355-si3g5dih	190	4	nucleic	nucleic	VBD
cord-277355-si3g5dih	190	5	acid	acid	NN
cord-277355-si3g5dih	190	6	vaccines	vaccine	NNS
cord-277355-si3g5dih	190	7	and	and	CC
cord-277355-si3g5dih	190	8	their	-PRON-	PRP$
cord-277355-si3g5dih	190	9	derived	derive	VBN
cord-277355-si3g5dih	190	10	SRIP	SRIP	NNP
cord-277355-si3g5dih	190	11	strategy	strategy	NN
cord-277355-si3g5dih	190	12	appear	appear	VBP
cord-277355-si3g5dih	190	13	promising	promise	VBG
cord-277355-si3g5dih	190	14	for	for	IN
cord-277355-si3g5dih	190	15	innovative	innovative	JJ
cord-277355-si3g5dih	190	16	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	190	17	vaccine	vaccine	NN
cord-277355-si3g5dih	190	18	development	development	NN
cord-277355-si3g5dih	190	19	,	,	,
cord-277355-si3g5dih	190	20	especially	especially	RB
cord-277355-si3g5dih	190	21	SRIPs	srip	NNS
cord-277355-si3g5dih	190	22	because	because	IN
cord-277355-si3g5dih	190	23	of	of	IN
cord-277355-si3g5dih	190	24	their	-PRON-	PRP$
cord-277355-si3g5dih	190	25	great	great	JJ
cord-277355-si3g5dih	190	26	capacity	capacity	NN
cord-277355-si3g5dih	190	27	to	to	TO
cord-277355-si3g5dih	190	28	provide	provide	VB
cord-277355-si3g5dih	190	29	protective	protective	JJ
cord-277355-si3g5dih	190	30	immunity	immunity	NN
cord-277355-si3g5dih	190	31	in	in	IN
cord-277355-si3g5dih	190	32	animal	animal	NN
cord-277355-si3g5dih	190	33	models	model	NNS
cord-277355-si3g5dih	190	34	after	after	IN
cord-277355-si3g5dih	190	35	only	only	RB
cord-277355-si3g5dih	190	36	a	a	DT
cord-277355-si3g5dih	190	37	single	single	JJ
cord-277355-si3g5dih	190	38	immunization	immunization	NN
cord-277355-si3g5dih	190	39	,	,	,
cord-277355-si3g5dih	190	40	and	and	CC
cord-277355-si3g5dih	190	41	they	-PRON-	PRP
cord-277355-si3g5dih	190	42	can	can	MD
cord-277355-si3g5dih	190	43	be	be	VB
cord-277355-si3g5dih	190	44	conveniently	conveniently	RB
cord-277355-si3g5dih	190	45	propagated	propagate	VBN
cord-277355-si3g5dih	190	46	and	and	CC
cord-277355-si3g5dih	190	47	produced	produce	VBN
cord-277355-si3g5dih	190	48	at	at	IN
cord-277355-si3g5dih	190	49	high	high	JJ
cord-277355-si3g5dih	190	50	titers	titer	NNS
cord-277355-si3g5dih	190	51	in	in	IN
cord-277355-si3g5dih	190	52	a	a	DT
cord-277355-si3g5dih	190	53	stable	stable	JJ
cord-277355-si3g5dih	190	54	cell	cell	NN
cord-277355-si3g5dih	190	55	line	line	NN
cord-277355-si3g5dih	190	56	;	;	:
cord-277355-si3g5dih	190	57	moreover	moreover	RB
cord-277355-si3g5dih	190	58	,	,	,
cord-277355-si3g5dih	190	59	they	-PRON-	PRP
cord-277355-si3g5dih	190	60	are	be	VBP
cord-277355-si3g5dih	190	61	reliably	reliably	RB
cord-277355-si3g5dih	190	62	safe	safe	JJ
cord-277355-si3g5dih	190	63	without	without	IN
cord-277355-si3g5dih	190	64	causing	cause	VBG
cord-277355-si3g5dih	190	65	spread	spread	NN
cord-277355-si3g5dih	190	66	infection	infection	NN
cord-277355-si3g5dih	190	67	.	.	.
cord-277355-si3g5dih	191	1	However	however	RB
cord-277355-si3g5dih	191	2	,	,	,
cord-277355-si3g5dih	191	3	SRIPs	srip	NNS
cord-277355-si3g5dih	191	4	suffer	suffer	VBP
cord-277355-si3g5dih	191	5	from	from	IN
cord-277355-si3g5dih	191	6	a	a	DT
cord-277355-si3g5dih	191	7	high	high	JJ
cord-277355-si3g5dih	191	8	cost	cost	NN
cord-277355-si3g5dih	191	9	of	of	IN
cord-277355-si3g5dih	191	10	production	production	NN
cord-277355-si3g5dih	191	11	and	and	CC
cord-277355-si3g5dih	191	12	storage	storage	NN
cord-277355-si3g5dih	191	13	and	and	CC
cord-277355-si3g5dih	191	14	are	be	VBP
cord-277355-si3g5dih	191	15	difficult	difficult	JJ
cord-277355-si3g5dih	191	16	to	to	TO
cord-277355-si3g5dih	191	17	purify	purify	VB
cord-277355-si3g5dih	191	18	[	[	-LRB-
cord-277355-si3g5dih	191	19	79	79	CD
cord-277355-si3g5dih	191	20	]	]	-RRB-
cord-277355-si3g5dih	191	21	.	.	.
cord-277355-si3g5dih	192	1	Currently	currently	RB
cord-277355-si3g5dih	192	2	,	,	,
cord-277355-si3g5dih	192	3	the	the	DT
cord-277355-si3g5dih	192	4	issues	issue	NNS
cord-277355-si3g5dih	192	5	of	of	IN
cord-277355-si3g5dih	192	6	mRNA	mrna	NN
cord-277355-si3g5dih	192	7	instability	instability	NN
cord-277355-si3g5dih	192	8	,	,	,
cord-277355-si3g5dih	192	9	inefficient	inefficient	JJ
cord-277355-si3g5dih	192	10	in	in	IN
cord-277355-si3g5dih	192	11	vivo	vivo	NN
cord-277355-si3g5dih	192	12	delivery	delivery	NN
cord-277355-si3g5dih	192	13	and	and	CC
cord-277355-si3g5dih	192	14	the	the	DT
cord-277355-si3g5dih	192	15	difficulty	difficulty	NN
cord-277355-si3g5dih	192	16	of	of	IN
cord-277355-si3g5dih	192	17	manufacturing	manufacturing	NN
cord-277355-si3g5dih	192	18	are	be	VBP
cord-277355-si3g5dih	192	19	no	no	RB
cord-277355-si3g5dih	192	20	longer	long	JJR
cord-277355-si3g5dih	192	21	barriers	barrier	NNS
cord-277355-si3g5dih	192	22	in	in	IN
cord-277355-si3g5dih	192	23	the	the	DT
cord-277355-si3g5dih	192	24	widespread	widespread	JJ
cord-277355-si3g5dih	192	25	implementation	implementation	NN
cord-277355-si3g5dih	192	26	of	of	IN
cord-277355-si3g5dih	192	27	mRNA	mRNA	NNP
cord-277355-si3g5dih	192	28	vaccines	vaccine	NNS
cord-277355-si3g5dih	192	29	.	.	.
cord-277355-si3g5dih	193	1	On	on	IN
cord-277355-si3g5dih	193	2	the	the	DT
cord-277355-si3g5dih	193	3	contrary	contrary	NN
cord-277355-si3g5dih	193	4	,	,	,
cord-277355-si3g5dih	193	5	mRNA	mRNA	NNP
cord-277355-si3g5dih	193	6	vaccines	vaccine	NNS
cord-277355-si3g5dih	193	7	have	have	VBP
cord-277355-si3g5dih	193	8	several	several	JJ
cord-277355-si3g5dih	193	9	beneficial	beneficial	JJ
cord-277355-si3g5dih	193	10	features	feature	NNS
cord-277355-si3g5dih	193	11	over	over	IN
cord-277355-si3g5dih	193	12	inactive	inactive	JJ
cord-277355-si3g5dih	193	13	and	and	CC
cord-277355-si3g5dih	193	14	live	live	RB
cord-277355-si3g5dih	193	15	-	-	HYPH
cord-277355-si3g5dih	193	16	attenuated	attenuate	VBN
cord-277355-si3g5dih	193	17	viruses	virus	NNS
cord-277355-si3g5dih	193	18	,	,	,
cord-277355-si3g5dih	193	19	as	as	RB
cord-277355-si3g5dih	193	20	well	well	RB
cord-277355-si3g5dih	193	21	as	as	IN
cord-277355-si3g5dih	193	22	DNA	dna	NN
cord-277355-si3g5dih	193	23	-	-	HYPH
cord-277355-si3g5dih	193	24	based	base	VBN
cord-277355-si3g5dih	193	25	vaccines	vaccine	NNS
cord-277355-si3g5dih	193	26	,	,	,
cord-277355-si3g5dih	193	27	such	such	JJ
cord-277355-si3g5dih	193	28	as	as	IN
cord-277355-si3g5dih	193	29	being	be	VBG
cord-277355-si3g5dih	193	30	safer	safe	JJR
cord-277355-si3g5dih	193	31	,	,	,
cord-277355-si3g5dih	193	32	being	be	VBG
cord-277355-si3g5dih	193	33	more	more	RBR
cord-277355-si3g5dih	193	34	efficient	efficient	JJ
cord-277355-si3g5dih	193	35	and	and	CC
cord-277355-si3g5dih	193	36	having	have	VBG
cord-277355-si3g5dih	193	37	the	the	DT
cord-277355-si3g5dih	193	38	potential	potential	NN
cord-277355-si3g5dih	193	39	for	for	IN
cord-277355-si3g5dih	193	40	rapid	rapid	JJ
cord-277355-si3g5dih	193	41	,	,	,
cord-277355-si3g5dih	193	42	low	low	JJ
cord-277355-si3g5dih	193	43	-	-	HYPH
cord-277355-si3g5dih	193	44	cost	cost	NN
cord-277355-si3g5dih	193	45	scalable	scalable	JJ
cord-277355-si3g5dih	193	46	manufacturing	manufacturing	NN
cord-277355-si3g5dih	193	47	(	(	-LRB-
cord-277355-si3g5dih	193	48	for	for	IN
cord-277355-si3g5dih	193	49	a	a	DT
cord-277355-si3g5dih	193	50	review	review	NN
cord-277355-si3g5dih	193	51	,	,	,
cord-277355-si3g5dih	193	52	see	see	VB
cord-277355-si3g5dih	193	53	[	[	-LRB-
cord-277355-si3g5dih	193	54	98	98	CD
cord-277355-si3g5dih	193	55	,	,	,
cord-277355-si3g5dih	193	56	99	99	CD
cord-277355-si3g5dih	193	57	]	]	-RRB-
cord-277355-si3g5dih	193	58	)	)	-RRB-
cord-277355-si3g5dih	193	59	,	,	,
cord-277355-si3g5dih	193	60	so	so	RB
cord-277355-si3g5dih	193	61	DC	DC	NNP
cord-277355-si3g5dih	193	62	replicon	replicon	NNP
cord-277355-si3g5dih	193	63	mRNA	mRNA	NNP
cord-277355-si3g5dih	193	64	vaccines	vaccine	NNS
cord-277355-si3g5dih	193	65	are	be	VBP
cord-277355-si3g5dih	193	66	also	also	RB
cord-277355-si3g5dih	193	67	very	very	RB
cord-277355-si3g5dih	193	68	promising	promising	JJ
cord-277355-si3g5dih	193	69	alternatives	alternative	NNS
cord-277355-si3g5dih	193	70	to	to	IN
cord-277355-si3g5dih	193	71	conventional	conventional	JJ
cord-277355-si3g5dih	193	72	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	193	73	vaccines	vaccine	NNS
cord-277355-si3g5dih	193	74	.	.	.
cord-277355-si3g5dih	194	1	In	in	IN
cord-277355-si3g5dih	194	2	addition	addition	NN
cord-277355-si3g5dih	194	3	to	to	IN
cord-277355-si3g5dih	194	4	having	have	VBG
cord-277355-si3g5dih	194	5	safety	safety	NN
cord-277355-si3g5dih	194	6	and	and	CC
cord-277355-si3g5dih	194	7	efficiency	efficiency	NN
cord-277355-si3g5dih	194	8	similar	similar	JJ
cord-277355-si3g5dih	194	9	to	to	IN
cord-277355-si3g5dih	194	10	those	those	DT
cord-277355-si3g5dih	194	11	of	of	IN
cord-277355-si3g5dih	194	12	SRIPs	srip	NNS
cord-277355-si3g5dih	194	13	,	,	,
cord-277355-si3g5dih	194	14	they	-PRON-	PRP
cord-277355-si3g5dih	194	15	are	be	VBP
cord-277355-si3g5dih	194	16	more	more	RBR
cord-277355-si3g5dih	194	17	suitable	suitable	JJ
cord-277355-si3g5dih	194	18	for	for	IN
cord-277355-si3g5dih	194	19	meeting	meet	VBG
cord-277355-si3g5dih	194	20	the	the	DT
cord-277355-si3g5dih	194	21	challenges	challenge	NNS
cord-277355-si3g5dih	194	22	of	of	IN
cord-277355-si3g5dih	194	23	rapid	rapid	JJ
cord-277355-si3g5dih	194	24	development	development	NN
cord-277355-si3g5dih	194	25	and	and	CC
cord-277355-si3g5dih	194	26	large	large	JJ
cord-277355-si3g5dih	194	27	-	-	HYPH
cord-277355-si3g5dih	194	28	scale	scale	NN
cord-277355-si3g5dih	194	29	deployment	deployment	NN
cord-277355-si3g5dih	194	30	for	for	IN
cord-277355-si3g5dih	194	31	emerging	emerge	VBG
cord-277355-si3g5dih	194	32	virus	virus	NN
cord-277355-si3g5dih	194	33	vaccines	vaccine	NNS
cord-277355-si3g5dih	194	34	[	[	-LRB-
cord-277355-si3g5dih	194	35	99	99	CD
cord-277355-si3g5dih	194	36	]	]	-RRB-
cord-277355-si3g5dih	194	37	.	.	.
cord-277355-si3g5dih	195	1	Over	over	IN
cord-277355-si3g5dih	195	2	the	the	DT
cord-277355-si3g5dih	195	3	past	past	JJ
cord-277355-si3g5dih	195	4	decades	decade	NNS
cord-277355-si3g5dih	195	5	,	,	,
cord-277355-si3g5dih	195	6	although	although	IN
cord-277355-si3g5dih	195	7	we	-PRON-	PRP
cord-277355-si3g5dih	195	8	have	have	VBP
cord-277355-si3g5dih	195	9	made	make	VBN
cord-277355-si3g5dih	195	10	important	important	JJ
cord-277355-si3g5dih	195	11	advances	advance	NNS
cord-277355-si3g5dih	195	12	in	in	IN
cord-277355-si3g5dih	195	13	our	-PRON-	PRP$
cord-277355-si3g5dih	195	14	understanding	understanding	NN
cord-277355-si3g5dih	195	15	of	of	IN
cord-277355-si3g5dih	195	16	key	key	JJ
cord-277355-si3g5dih	195	17	steps	step	NNS
cord-277355-si3g5dih	195	18	in	in	IN
cord-277355-si3g5dih	195	19	the	the	DT
cord-277355-si3g5dih	195	20	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	195	21	life	life	NN
cord-277355-si3g5dih	195	22	cycle	cycle	NN
cord-277355-si3g5dih	195	23	and	and	CC
cord-277355-si3g5dih	195	24	their	-PRON-	PRP$
cord-277355-si3g5dih	195	25	application	application	NN
cord-277355-si3g5dih	195	26	to	to	IN
cord-277355-si3g5dih	195	27	development	development	NN
cord-277355-si3g5dih	195	28	of	of	IN
cord-277355-si3g5dih	195	29	novel	novel	JJ
cord-277355-si3g5dih	195	30	vaccines	vaccine	NNS
cord-277355-si3g5dih	195	31	,	,	,
cord-277355-si3g5dih	195	32	many	many	JJ
cord-277355-si3g5dih	195	33	aspects	aspect	NNS
cord-277355-si3g5dih	195	34	of	of	IN
cord-277355-si3g5dih	195	35	the	the	DT
cord-277355-si3g5dih	195	36	viral	viral	JJ
cord-277355-si3g5dih	195	37	life	life	NN
cord-277355-si3g5dih	195	38	cycle	cycle	NN
cord-277355-si3g5dih	195	39	remain	remain	VBP
cord-277355-si3g5dih	195	40	obscure	obscure	JJ
cord-277355-si3g5dih	195	41	.	.	.
cord-277355-si3g5dih	196	1	Flaviviral	Flaviviral	NNP
cord-277355-si3g5dih	196	2	CP	CP	NNP
cord-277355-si3g5dih	196	3	plays	play	VBZ
cord-277355-si3g5dih	196	4	a	a	DT
cord-277355-si3g5dih	196	5	crucial	crucial	JJ
cord-277355-si3g5dih	196	6	role	role	NN
cord-277355-si3g5dih	196	7	in	in	IN
cord-277355-si3g5dih	196	8	viral	viral	JJ
cord-277355-si3g5dih	196	9	assembly	assembly	NN
cord-277355-si3g5dih	196	10	.	.	.
cord-277355-si3g5dih	197	1	We	-PRON-	PRP
cord-277355-si3g5dih	197	2	have	have	VBP
cord-277355-si3g5dih	197	3	learned	learn	VBN
cord-277355-si3g5dih	197	4	about	about	IN
cord-277355-si3g5dih	197	5	structures	structure	NNS
cord-277355-si3g5dih	197	6	,	,	,
cord-277355-si3g5dih	197	7	posttranslational	posttranslational	JJ
cord-277355-si3g5dih	197	8	cleavage	cleavage	NN
cord-277355-si3g5dih	197	9	and	and	CC
cord-277355-si3g5dih	197	10	maturation	maturation	NN
cord-277355-si3g5dih	197	11	,	,	,
cord-277355-si3g5dih	197	12	and	and	CC
cord-277355-si3g5dih	197	13	the	the	DT
cord-277355-si3g5dih	197	14	subcellular	subcellular	JJ
cord-277355-si3g5dih	197	15	distribution	distribution	NN
cord-277355-si3g5dih	197	16	of	of	IN
cord-277355-si3g5dih	197	17	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	197	18	CP	cp	NN
cord-277355-si3g5dih	197	19	;	;	:
cord-277355-si3g5dih	197	20	however	however	RB
cord-277355-si3g5dih	197	21	,	,	,
cord-277355-si3g5dih	197	22	how	how	WRB
cord-277355-si3g5dih	197	23	the	the	DT
cord-277355-si3g5dih	197	24	NC	NC	NNP
cord-277355-si3g5dih	197	25	is	be	VBZ
cord-277355-si3g5dih	197	26	assembled	assemble	VBN
cord-277355-si3g5dih	197	27	and	and	CC
cord-277355-si3g5dih	197	28	dissociated	dissociate	VBN
cord-277355-si3g5dih	197	29	,	,	,
cord-277355-si3g5dih	197	30	how	how	WRB
cord-277355-si3g5dih	197	31	the	the	DT
cord-277355-si3g5dih	197	32	NC	NC	NNP
cord-277355-si3g5dih	197	33	should	should	MD
cord-277355-si3g5dih	197	34	be	be	VB
cord-277355-si3g5dih	197	35	incorporated	incorporate	VBN
cord-277355-si3g5dih	197	36	into	into	IN
cord-277355-si3g5dih	197	37	viral	viral	JJ
cord-277355-si3g5dih	197	38	particles	particle	NNS
cord-277355-si3g5dih	197	39	and	and	CC
cord-277355-si3g5dih	197	40	the	the	DT
cord-277355-si3g5dih	197	41	process	process	NN
cord-277355-si3g5dih	197	42	of	of	IN
cord-277355-si3g5dih	197	43	NC	NC	NNP
cord-277355-si3g5dih	197	44	uncoating	uncoating	NN
cord-277355-si3g5dih	197	45	are	be	VBP
cord-277355-si3g5dih	197	46	not	not	RB
cord-277355-si3g5dih	197	47	well	well	RB
cord-277355-si3g5dih	197	48	explained	explain	VBN
cord-277355-si3g5dih	197	49	to	to	IN
cord-277355-si3g5dih	197	50	date	date	NN
cord-277355-si3g5dih	197	51	.	.	.
cord-277355-si3g5dih	198	1	Perhaps	perhaps	RB
cord-277355-si3g5dih	198	2	structural	structural	JJ
cord-277355-si3g5dih	198	3	studies	study	NNS
cord-277355-si3g5dih	198	4	on	on	IN
cord-277355-si3g5dih	198	5	the	the	DT
cord-277355-si3g5dih	198	6	NC	NC	NNP
cord-277355-si3g5dih	198	7	in	in	IN
cord-277355-si3g5dih	198	8	the	the	DT
cord-277355-si3g5dih	198	9	future	future	NN
cord-277355-si3g5dih	198	10	will	will	MD
cord-277355-si3g5dih	198	11	aid	aid	VB
cord-277355-si3g5dih	198	12	in	in	IN
cord-277355-si3g5dih	198	13	our	-PRON-	PRP$
cord-277355-si3g5dih	198	14	understanding	understanding	NN
cord-277355-si3g5dih	198	15	of	of	IN
cord-277355-si3g5dih	198	16	these	these	DT
cord-277355-si3g5dih	198	17	aspects	aspect	NNS
cord-277355-si3g5dih	198	18	.	.	.
cord-277355-si3g5dih	199	1	Due	due	IN
cord-277355-si3g5dih	199	2	to	to	IN
cord-277355-si3g5dih	199	3	the	the	DT
cord-277355-si3g5dih	199	4	lack	lack	NN
cord-277355-si3g5dih	199	5	of	of	IN
cord-277355-si3g5dih	199	6	specific	specific	JJ
cord-277355-si3g5dih	199	7	treatments	treatment	NNS
cord-277355-si3g5dih	199	8	for	for	IN
cord-277355-si3g5dih	199	9	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	199	10	-	-	HYPH
cord-277355-si3g5dih	199	11	related	relate	VBN
cord-277355-si3g5dih	199	12	diseases	disease	NNS
cord-277355-si3g5dih	199	13	,	,	,
cord-277355-si3g5dih	199	14	vaccines	vaccine	NNS
cord-277355-si3g5dih	199	15	are	be	VBP
cord-277355-si3g5dih	199	16	the	the	DT
cord-277355-si3g5dih	199	17	most	most	RBS
cord-277355-si3g5dih	199	18	powerful	powerful	JJ
cord-277355-si3g5dih	199	19	measures	measure	NNS
cord-277355-si3g5dih	199	20	to	to	TO
cord-277355-si3g5dih	199	21	prevent	prevent	VB
cord-277355-si3g5dih	199	22	flaviviral	flaviviral	JJ
cord-277355-si3g5dih	199	23	infection	infection	NN
cord-277355-si3g5dih	199	24	and	and	CC
cord-277355-si3g5dih	199	25	viral	viral	JJ
cord-277355-si3g5dih	199	26	spread	spread	NN
cord-277355-si3g5dih	199	27	.	.	.
cord-277355-si3g5dih	200	1	Although	although	IN
cord-277355-si3g5dih	200	2	vaccines	vaccine	NNS
cord-277355-si3g5dih	200	3	have	have	VBP
cord-277355-si3g5dih	200	4	achieved	achieve	VBN
cord-277355-si3g5dih	200	5	success	success	NN
cord-277355-si3g5dih	200	6	with	with	IN
cord-277355-si3g5dih	200	7	respect	respect	NN
cord-277355-si3g5dih	200	8	to	to	IN
cord-277355-si3g5dih	200	9	YFV	YFV	NNP
cord-277355-si3g5dih	200	10	,	,	,
cord-277355-si3g5dih	200	11	TBEV	TBEV	NNP
cord-277355-si3g5dih	200	12	and	and	CC
cord-277355-si3g5dih	200	13	JEV	JEV	NNP
cord-277355-si3g5dih	200	14	,	,	,
cord-277355-si3g5dih	200	15	there	there	EX
cord-277355-si3g5dih	200	16	is	be	VBZ
cord-277355-si3g5dih	200	17	still	still	RB
cord-277355-si3g5dih	200	18	room	room	NN
cord-277355-si3g5dih	200	19	for	for	IN
cord-277355-si3g5dih	200	20	improvement	improvement	NN
cord-277355-si3g5dih	200	21	concerning	concern	VBG
cord-277355-si3g5dih	200	22	safety	safety	NN
cord-277355-si3g5dih	200	23	,	,	,
cord-277355-si3g5dih	200	24	efficiency	efficiency	NN
cord-277355-si3g5dih	200	25	,	,	,
cord-277355-si3g5dih	200	26	and	and	CC
cord-277355-si3g5dih	200	27	low	low	JJ
cord-277355-si3g5dih	200	28	cost	cost	NN
cord-277355-si3g5dih	200	29	.	.	.
cord-277355-si3g5dih	201	1	As	as	IN
cord-277355-si3g5dih	201	2	a	a	DT
cord-277355-si3g5dih	201	3	viable	viable	JJ
cord-277355-si3g5dih	201	4	approach	approach	NN
cord-277355-si3g5dih	201	5	,	,	,
cord-277355-si3g5dih	201	6	C	c	NN
cord-277355-si3g5dih	201	7	-	-	HYPH
cord-277355-si3g5dih	201	8	deleted	delete	VBN
cord-277355-si3g5dih	201	9	genome	genome	NN
cord-277355-si3g5dih	201	10	-	-	HYPH
cord-277355-si3g5dih	201	11	generated	generate	VBN
cord-277355-si3g5dih	201	12	live	live	NN
cord-277355-si3g5dih	201	13	-	-	HYPH
cord-277355-si3g5dih	201	14	attenuated	attenuate	VBN
cord-277355-si3g5dih	201	15	viruses	virus	NNS
cord-277355-si3g5dih	201	16	are	be	VBP
cord-277355-si3g5dih	201	17	efficient	efficient	JJ
cord-277355-si3g5dih	201	18	and	and	CC
cord-277355-si3g5dih	201	19	convenient	convenient	JJ
cord-277355-si3g5dih	201	20	approaches	approach	NNS
cord-277355-si3g5dih	201	21	with	with	IN
cord-277355-si3g5dih	201	22	several	several	JJ
cord-277355-si3g5dih	201	23	advantages	advantage	NNS
cord-277355-si3g5dih	201	24	over	over	IN
cord-277355-si3g5dih	201	25	traditional	traditional	JJ
cord-277355-si3g5dih	201	26	methods	method	NNS
cord-277355-si3g5dih	201	27	for	for	IN
cord-277355-si3g5dih	201	28	attenuation	attenuation	NN
cord-277355-si3g5dih	201	29	of	of	IN
cord-277355-si3g5dih	201	30	viruses	virus	NNS
cord-277355-si3g5dih	201	31	,	,	,
cord-277355-si3g5dih	201	32	but	but	CC
cord-277355-si3g5dih	201	33	safety	safety	NN
cord-277355-si3g5dih	201	34	concerns	concern	NNS
cord-277355-si3g5dih	201	35	for	for	IN
cord-277355-si3g5dih	201	36	live	live	JJ
cord-277355-si3g5dih	201	37	viruses	virus	NNS
cord-277355-si3g5dih	201	38	still	still	RB
cord-277355-si3g5dih	201	39	exist	exist	VBP
cord-277355-si3g5dih	201	40	.	.	.
cord-277355-si3g5dih	202	1	By	by	IN
cord-277355-si3g5dih	202	2	contrast	contrast	NN
cord-277355-si3g5dih	202	3	,	,	,
cord-277355-si3g5dih	202	4	the	the	DT
cord-277355-si3g5dih	202	5	noninfectious	noninfectious	JJ
cord-277355-si3g5dih	202	6	DC	DC	NNP
cord-277355-si3g5dih	202	7	replicon	replicon	NN
cord-277355-si3g5dih	202	8	displays	display	VBZ
cord-277355-si3g5dih	202	9	significant	significant	JJ
cord-277355-si3g5dih	202	10	potential	potential	NN
cord-277355-si3g5dih	202	11	.	.	.
cord-277355-si3g5dih	203	1	Both	both	DT
cord-277355-si3g5dih	203	2	viral	viral	JJ
cord-277355-si3g5dih	203	3	delivery	delivery	NN
cord-277355-si3g5dih	203	4	(	(	-LRB-
cord-277355-si3g5dih	203	5	SRIPs	SRIPs	NNP
cord-277355-si3g5dih	203	6	)	)	-RRB-
cord-277355-si3g5dih	203	7	and	and	CC
cord-277355-si3g5dih	203	8	nonviral	nonviral	JJ
cord-277355-si3g5dih	203	9	delivery	delivery	NN
cord-277355-si3g5dih	203	10	(	(	-LRB-
cord-277355-si3g5dih	203	11	nucleic	nucleic	JJ
cord-277355-si3g5dih	203	12	acid	acid	NN
cord-277355-si3g5dih	203	13	vaccine	vaccine	NN
cord-277355-si3g5dih	203	14	)	)	-RRB-
cord-277355-si3g5dih	203	15	of	of	IN
cord-277355-si3g5dih	203	16	Table	Table	NNP
cord-277355-si3g5dih	203	17	1	1	CD
cord-277355-si3g5dih	203	18	Attenuated	attenuate	VBN
cord-277355-si3g5dih	203	19	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	203	20	generated	generate	VBN
cord-277355-si3g5dih	203	21	by	by	IN
cord-277355-si3g5dih	203	22	C	c	NN
cord-277355-si3g5dih	203	23	-	-	HYPH
cord-277355-si3g5dih	203	24	deletion	deletion	NN
cord-277355-si3g5dih	203	25	.	.	.
cord-277355-si3g5dih	204	1	Deletion	deletion	NN
cord-277355-si3g5dih	204	2	size	size	NN
cord-277355-si3g5dih	204	3	a	a	DT
cord-277355-si3g5dih	204	4	Minimal	minimal	JJ
cord-277355-si3g5dih	204	5	protective	protective	JJ
cord-277355-si3g5dih	204	6	dose	dose	NN
cord-277355-si3g5dih	204	7	Animal	Animal	NNP
cord-277355-si3g5dih	204	8	model	model	NN
cord-277355-si3g5dih	205	1	Reference	reference	NN
cord-277355-si3g5dih	205	2	TBEV	TBEV	NNP
cord-277355-si3g5dih	205	3	C(D28	C(D28	NNP
cord-277355-si3g5dih	205	4	-	-	HYPH
cord-277355-si3g5dih	205	5	43	43	CD
cord-277355-si3g5dih	205	6	)	)	-RRB-
cord-277355-si3g5dih	205	7	10	10	CD
cord-277355-si3g5dih	206	1	2.6	2.6	CD
cord-277355-si3g5dih	206	2	PFU	pfu	NN
cord-277355-si3g5dih	206	3	mouse	mouse	NN
cord-277355-si3g5dih	206	4	[	[	-LRB-
cord-277355-si3g5dih	206	5	20	20	CD
cord-277355-si3g5dih	206	6	]	]	-RRB-
cord-277355-si3g5dih	207	1	TBEV	TBEV	NNP
cord-277355-si3g5dih	207	2	C(D28	C(D28	NNP
cord-277355-si3g5dih	207	3	-	-	HYPH
cord-277355-si3g5dih	207	4	48	48	CD
cord-277355-si3g5dih	207	5	/	/	SYM
cord-277355-si3g5dih	207	6	Q70L	Q70L	NNP
cord-277355-si3g5dih	207	7	)	)	-RRB-
cord-277355-si3g5dih	207	8	and	and	CC
cord-277355-si3g5dih	207	9	C(D28	C(D28	NNP
cord-277355-si3g5dih	207	10	-	-	HYPH
cord-277355-si3g5dih	207	11	48	48	CD
cord-277355-si3g5dih	207	12	/	/	SYM
cord-277355-si3g5dih	207	13	Du78	Du78	NNP
cord-277355-si3g5dih	207	14	-	-	HYPH
cord-277355-si3g5dih	207	15	85)~1	85)~1	CD
cord-277355-si3g5dih	207	16	0	0	NFP
cord-277355-si3g5dih	208	1	PFU	pfu	NN
cord-277355-si3g5dih	208	2	mouse	mouse	NN
cord-277355-si3g5dih	208	3	[	[	-LRB-
cord-277355-si3g5dih	208	4	9	9	CD
cord-277355-si3g5dih	208	5	]	]	-RRB-
cord-277355-si3g5dih	209	1	WNV	WNV	NNP
cord-277355-si3g5dih	209	2	C(D40	C(D40	NNP
cord-277355-si3g5dih	209	3	-	-	HYPH
cord-277355-si3g5dih	209	4	75	75	NNP
cord-277355-si3g5dih	209	5	/	/	SYM
cord-277355-si3g5dih	209	6	D39E	d39e	NN
cord-277355-si3g5dih	209	7	)	)	-RRB-
cord-277355-si3g5dih	209	8	and	and	CC
cord-277355-si3g5dih	209	9	C(D51	C(D51	NNP
cord-277355-si3g5dih	209	10	-	-	HYPH
cord-277355-si3g5dih	209	11	87)~1	87)~1	CD
cord-277355-si3g5dih	209	12	0	0	NFP
cord-277355-si3g5dih	210	1	PFU	pfu	NN
cord-277355-si3g5dih	210	2	mouse	mouse	NN
cord-277355-si3g5dih	210	3	[	[	-LRB-
cord-277355-si3g5dih	210	4	23	23	CD
cord-277355-si3g5dih	210	5	,	,	,
cord-277355-si3g5dih	210	6	76	76	CD
cord-277355-si3g5dih	210	7	]	]	-RRB-
cord-277355-si3g5dih	210	8	DENV	DENV	NNP
cord-277355-si3g5dih	210	9	C(D41	C(D41	NNP
cord-277355-si3g5dih	210	10	-	-	HYPH
cord-277355-si3g5dih	210	11	49	49	CD
cord-277355-si3g5dih	210	12	)	)	-RRB-
cord-277355-si3g5dih	210	13	,	,	,
cord-277355-si3g5dih	210	14	C(D42	C(D42	NNP
cord-277355-si3g5dih	210	15	-	-	HYPH
cord-277355-si3g5dih	210	16	51	51	CD
cord-277355-si3g5dih	210	17	)	)	-RRB-
cord-277355-si3g5dih	211	1	ND	ND	NNP
cord-277355-si3g5dih	211	2	b	b	NNP
cord-277355-si3g5dih	211	3	mouse	mouse	NN
cord-277355-si3g5dih	211	4	[	[	-LRB-
cord-277355-si3g5dih	211	5	75	75	CD
cord-277355-si3g5dih	211	6	]	]	-RRB-
cord-277355-si3g5dih	212	1	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	212	2	C(D63	C(D63	NNP
cord-277355-si3g5dih	212	3	-	-	HYPH
cord-277355-si3g5dih	212	4	71	71	CD
cord-277355-si3g5dih	212	5	)	)	-RRB-
cord-277355-si3g5dih	213	1	+	+	CC
cord-277355-si3g5dih	213	2	prM	prm	JJ
cord-277355-si3g5dih	213	3	-	-	HYPH
cord-277355-si3g5dih	213	4	E21	e21	NN
cord-277355-si3g5dih	213	5	K	K	NNP
cord-277355-si3g5dih	213	6	+	+	CC
cord-277355-si3g5dih	213	7	NS2B	NS2B	NNP
cord-277355-si3g5dih	213	8	-	-	HYPH
cord-277355-si3g5dih	213	9	E27	E27	NNP
cord-277355-si3g5dih	213	10	G	G	NNP
cord-277355-si3g5dih	213	11	10	10	CD
cord-277355-si3g5dih	213	12	5	5	CD
cord-277355-si3g5dih	213	13	FFU	FFU	NNP
cord-277355-si3g5dih	213	14	mouse	mouse	NN
cord-277355-si3g5dih	213	15	[	[	-LRB-
cord-277355-si3g5dih	213	16	33	33	CD
cord-277355-si3g5dih	213	17	]	]	-RRB-
cord-277355-si3g5dih	214	1	a	a	LS
cord-277355-si3g5dih	215	1	The	the	DT
cord-277355-si3g5dih	215	2	deleted	delete	VBN
cord-277355-si3g5dih	215	3	amino	amino	NN
cord-277355-si3g5dih	215	4	acids	acid	NNS
cord-277355-si3g5dih	215	5	in	in	IN
cord-277355-si3g5dih	215	6	capsid	capsid	NN
cord-277355-si3g5dih	215	7	proteins	protein	NNS
cord-277355-si3g5dih	215	8	are	be	VBP
cord-277355-si3g5dih	215	9	highlighted	highlight	VBN
cord-277355-si3g5dih	215	10	with	with	IN
cord-277355-si3g5dih	215	11	underscores	underscore	NNS
cord-277355-si3g5dih	215	12	.	.	.
cord-277355-si3g5dih	216	1	b	b	LS
cord-277355-si3g5dih	216	2	ND	ND	NNP
cord-277355-si3g5dih	216	3	:	:	:
cord-277355-si3g5dih	216	4	not	not	RB
cord-277355-si3g5dih	216	5	determined	determine	VBN
cord-277355-si3g5dih	216	6	.	.	.
cord-277355-si3g5dih	217	1	the	the	DT
cord-277355-si3g5dih	217	2	DC	DC	NNP
cord-277355-si3g5dih	217	3	replicon	replicon	NN
cord-277355-si3g5dih	217	4	have	have	VBP
cord-277355-si3g5dih	217	5	potential	potential	NN
cord-277355-si3g5dih	217	6	,	,	,
cord-277355-si3g5dih	217	7	and	and	CC
cord-277355-si3g5dih	217	8	mRNA	mrna	NN
cord-277355-si3g5dih	217	9	vaccines	vaccine	NNS
cord-277355-si3g5dih	217	10	of	of	IN
cord-277355-si3g5dih	217	11	the	the	DT
cord-277355-si3g5dih	217	12	DC	DC	NNP
cord-277355-si3g5dih	217	13	replicon	replicon	NN
cord-277355-si3g5dih	217	14	are	be	VBP
cord-277355-si3g5dih	217	15	a	a	DT
cord-277355-si3g5dih	217	16	particularly	particularly	RB
cord-277355-si3g5dih	217	17	promising	promising	JJ
cord-277355-si3g5dih	217	18	alternative	alternative	JJ
cord-277355-si3g5dih	217	19	approach	approach	NN
cord-277355-si3g5dih	217	20	[	[	-LRB-
cord-277355-si3g5dih	217	21	79	79	CD
cord-277355-si3g5dih	217	22	,	,	,
cord-277355-si3g5dih	217	23	99	99	CD
cord-277355-si3g5dih	217	24	]	]	-RRB-
cord-277355-si3g5dih	217	25	.	.	.
cord-277355-si3g5dih	218	1	However	however	RB
cord-277355-si3g5dih	218	2	,	,	,
cord-277355-si3g5dih	218	3	to	to	TO
cord-277355-si3g5dih	218	4	meet	meet	VB
cord-277355-si3g5dih	218	5	the	the	DT
cord-277355-si3g5dih	218	6	need	need	NN
cord-277355-si3g5dih	218	7	of	of	IN
cord-277355-si3g5dih	218	8	public	public	JJ
cord-277355-si3g5dih	218	9	health	health	NN
cord-277355-si3g5dih	218	10	emergencies	emergency	NNS
cord-277355-si3g5dih	218	11	caused	cause	VBN
cord-277355-si3g5dih	218	12	by	by	IN
cord-277355-si3g5dih	218	13	novel	novel	NN
cord-277355-si3g5dih	218	14	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	218	15	(	(	-LRB-
cord-277355-si3g5dih	218	16	suggested	suggest	VBN
cord-277355-si3g5dih	218	17	by	by	IN
cord-277355-si3g5dih	218	18	ZIKV	ZIKV	NNP
cord-277355-si3g5dih	218	19	)	)	-RRB-
cord-277355-si3g5dih	218	20	,	,	,
cord-277355-si3g5dih	218	21	the	the	DT
cord-277355-si3g5dih	218	22	mRNA	mRNA	NNP
cord-277355-si3g5dih	218	23	vaccines	vaccine	NNS
cord-277355-si3g5dih	218	24	of	of	IN
cord-277355-si3g5dih	218	25	the	the	DT
cord-277355-si3g5dih	218	26	DC	DC	NNP
cord-277355-si3g5dih	218	27	replicon	replicon	NN
cord-277355-si3g5dih	218	28	can	can	MD
cord-277355-si3g5dih	218	29	be	be	VB
cord-277355-si3g5dih	218	30	rapidly	rapidly	RB
cord-277355-si3g5dih	218	31	put	put	VBN
cord-277355-si3g5dih	218	32	into	into	IN
cord-277355-si3g5dih	218	33	use	use	NN
cord-277355-si3g5dih	218	34	,	,	,
cord-277355-si3g5dih	218	35	which	which	WDT
cord-277355-si3g5dih	218	36	is	be	VBZ
cord-277355-si3g5dih	218	37	also	also	RB
cord-277355-si3g5dih	218	38	an	an	DT
cord-277355-si3g5dih	218	39	advantage	advantage	NN
cord-277355-si3g5dih	218	40	.	.	.
cord-277355-si3g5dih	218	41	 	 	_SP
cord-277355-si3g5dih	219	1	The	the	DT
cord-277355-si3g5dih	219	2	global	global	JJ
cord-277355-si3g5dih	219	3	distribution	distribution	NN
cord-277355-si3g5dih	219	4	and	and	CC
cord-277355-si3g5dih	219	5	burden	burden	NN
cord-277355-si3g5dih	219	6	of	of	IN
cord-277355-si3g5dih	219	7	dengue	dengue	NN
cord-277355-si3g5dih	219	8	Structure	structure	NN
cord-277355-si3g5dih	219	9	of	of	IN
cord-277355-si3g5dih	219	10	dengue	dengue	NN
cord-277355-si3g5dih	219	11	virus	virus	NN
cord-277355-si3g5dih	219	12	:	:	:
cord-277355-si3g5dih	219	13	implications	implication	NNS
cord-277355-si3g5dih	219	14	for	for	IN
cord-277355-si3g5dih	219	15	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	219	16	organization	organization	NN
cord-277355-si3g5dih	219	17	,	,	,
cord-277355-si3g5dih	219	18	maturation	maturation	NN
cord-277355-si3g5dih	219	19	,	,	,
cord-277355-si3g5dih	219	20	and	and	CC
cord-277355-si3g5dih	219	21	fusion	fusion	NN
cord-277355-si3g5dih	219	22	Visualization	visualization	NN
cord-277355-si3g5dih	219	23	of	of	IN
cord-277355-si3g5dih	219	24	membrane	membrane	NN
cord-277355-si3g5dih	219	25	protein	protein	NN
cord-277355-si3g5dih	219	26	domains	domain	NNS
cord-277355-si3g5dih	219	27	by	by	IN
cord-277355-si3g5dih	219	28	cryo	cryo	NN
cord-277355-si3g5dih	219	29	-	-	HYPH
cord-277355-si3g5dih	219	30	electron	electron	NN
cord-277355-si3g5dih	219	31	microscopy	microscopy	NN
cord-277355-si3g5dih	219	32	of	of	IN
cord-277355-si3g5dih	219	33	dengue	dengue	NN
cord-277355-si3g5dih	219	34	virus	virus	NN
cord-277355-si3g5dih	219	35	Structure	Structure	NNP
cord-277355-si3g5dih	219	36	of	of	IN
cord-277355-si3g5dih	219	37	immature	immature	JJ
cord-277355-si3g5dih	219	38	West	West	NNP
cord-277355-si3g5dih	219	39	Nile	Nile	NNP
cord-277355-si3g5dih	219	40	virus	virus	NN
cord-277355-si3g5dih	219	41	Structure	structure	NN
cord-277355-si3g5dih	219	42	of	of	IN
cord-277355-si3g5dih	219	43	the	the	DT
cord-277355-si3g5dih	219	44	immature	immature	JJ
cord-277355-si3g5dih	219	45	dengue	dengue	NN
cord-277355-si3g5dih	219	46	virus	virus	NN
cord-277355-si3g5dih	219	47	at	at	IN
cord-277355-si3g5dih	219	48	low	low	JJ
cord-277355-si3g5dih	219	49	pH	ph	NN
cord-277355-si3g5dih	219	50	primes	prime	NNS
cord-277355-si3g5dih	219	51	proteolytic	proteolytic	JJ
cord-277355-si3g5dih	219	52	maturation	maturation	NN
cord-277355-si3g5dih	220	1	The	the	DT
cord-277355-si3g5dih	220	2	3.8	3.8	CD
cord-277355-si3g5dih	220	3	angstrom	angstrom	NN
cord-277355-si3g5dih	220	4	resolution	resolution	NN
cord-277355-si3g5dih	220	5	cryo	cryo	NN
cord-277355-si3g5dih	220	6	-	-	HYPH
cord-277355-si3g5dih	220	7	EM	EM	NNP
cord-277355-si3g5dih	220	8	structure	structure	NN
cord-277355-si3g5dih	220	9	of	of	IN
cord-277355-si3g5dih	220	10	Zika	Zika	NNP
cord-277355-si3g5dih	220	11	virus	virus	NN
cord-277355-si3g5dih	221	1	A	a	DT
cord-277355-si3g5dih	221	2	conserved	conserved	JJ
cord-277355-si3g5dih	221	3	internal	internal	JJ
cord-277355-si3g5dih	221	4	hydrophobic	hydrophobic	JJ
cord-277355-si3g5dih	221	5	domain	domain	NN
cord-277355-si3g5dih	221	6	mediates	mediate	VBZ
cord-277355-si3g5dih	221	7	the	the	DT
cord-277355-si3g5dih	221	8	stable	stable	JJ
cord-277355-si3g5dih	221	9	membrane	membrane	NN
cord-277355-si3g5dih	221	10	integration	integration	NN
cord-277355-si3g5dih	221	11	of	of	IN
cord-277355-si3g5dih	221	12	the	the	DT
cord-277355-si3g5dih	221	13	dengue	dengue	NN
cord-277355-si3g5dih	221	14	virus	virus	NN
cord-277355-si3g5dih	221	15	capsid	capsid	NN
cord-277355-si3g5dih	221	16	protein	protein	NN
cord-277355-si3g5dih	221	17	Spontaneous	spontaneous	JJ
cord-277355-si3g5dih	221	18	mutations	mutation	NNS
cord-277355-si3g5dih	221	19	restore	restore	VBP
cord-277355-si3g5dih	221	20	the	the	DT
cord-277355-si3g5dih	221	21	viability	viability	NN
cord-277355-si3g5dih	221	22	of	of	IN
cord-277355-si3g5dih	221	23	tick	tick	NN
cord-277355-si3g5dih	221	24	-	-	HYPH
cord-277355-si3g5dih	221	25	borne	bear	VBN
cord-277355-si3g5dih	221	26	encephalitis	encephalitis	JJ
cord-277355-si3g5dih	221	27	virus	virus	NN
cord-277355-si3g5dih	221	28	mutants	mutant	NNS
cord-277355-si3g5dih	221	29	with	with	IN
cord-277355-si3g5dih	221	30	large	large	JJ
cord-277355-si3g5dih	221	31	deletions	deletion	NNS
cord-277355-si3g5dih	221	32	in	in	IN
cord-277355-si3g5dih	221	33	protein	protein	NN
cord-277355-si3g5dih	221	34	C	C	NNP
cord-277355-si3g5dih	221	35	Solution	Solution	NNP
cord-277355-si3g5dih	221	36	structure	structure	NN
cord-277355-si3g5dih	221	37	of	of	IN
cord-277355-si3g5dih	221	38	dengue	dengue	NN
cord-277355-si3g5dih	221	39	virus	virus	NN
cord-277355-si3g5dih	221	40	capsid	capsid	NN
cord-277355-si3g5dih	221	41	protein	protein	NN
cord-277355-si3g5dih	221	42	reveals	reveal	VBZ
cord-277355-si3g5dih	221	43	another	another	DT
cord-277355-si3g5dih	221	44	fold	fold	NNP
cord-277355-si3g5dih	221	45	Dynamics	Dynamics	NNPS
cord-277355-si3g5dih	221	46	of	of	IN
cord-277355-si3g5dih	221	47	zika	zika	NNP
cord-277355-si3g5dih	221	48	virus	virus	NNP
cord-277355-si3g5dih	221	49	capsid	capsid	NN
cord-277355-si3g5dih	221	50	protein	protein	NN
cord-277355-si3g5dih	221	51	in	in	IN
cord-277355-si3g5dih	221	52	solution	solution	NN
cord-277355-si3g5dih	221	53	:	:	:
cord-277355-si3g5dih	221	54	the	the	DT
cord-277355-si3g5dih	221	55	properties	property	NNS
cord-277355-si3g5dih	221	56	and	and	CC
cord-277355-si3g5dih	221	57	exposure	exposure	NN
cord-277355-si3g5dih	221	58	of	of	IN
cord-277355-si3g5dih	221	59	the	the	DT
cord-277355-si3g5dih	221	60	hydrophobic	hydrophobic	JJ
cord-277355-si3g5dih	221	61	cleft	cleft	NN
cord-277355-si3g5dih	221	62	are	be	VBP
cord-277355-si3g5dih	221	63	controlled	control	VBN
cord-277355-si3g5dih	221	64	by	by	IN
cord-277355-si3g5dih	221	65	the	the	DT
cord-277355-si3g5dih	221	66	alpha	alpha	NN
cord-277355-si3g5dih	221	67	-	-	HYPH
cord-277355-si3g5dih	221	68	helix	helix	NN
cord-277355-si3g5dih	221	69	1	1	CD
cord-277355-si3g5dih	221	70	sequence	sequence	NN
cord-277355-si3g5dih	222	1	West	West	NNP
cord-277355-si3g5dih	222	2	Nile	Nile	NNP
cord-277355-si3g5dih	222	3	virus	virus	NN
cord-277355-si3g5dih	222	4	core	core	NN
cord-277355-si3g5dih	222	5	protein	protein	NN
cord-277355-si3g5dih	222	6	;	;	:
cord-277355-si3g5dih	222	7	tetramer	tetramer	NN
cord-277355-si3g5dih	222	8	structure	structure	NN
cord-277355-si3g5dih	222	9	and	and	CC
cord-277355-si3g5dih	222	10	ribbon	ribbon	NN
cord-277355-si3g5dih	222	11	formation	formation	NN
cord-277355-si3g5dih	222	12	Crystal	Crystal	NNP
cord-277355-si3g5dih	222	13	structure	structure	NN
cord-277355-si3g5dih	222	14	of	of	IN
cord-277355-si3g5dih	222	15	the	the	DT
cord-277355-si3g5dih	222	16	capsid	capsid	JJ
cord-277355-si3g5dih	222	17	protein	protein	NN
cord-277355-si3g5dih	222	18	from	from	IN
cord-277355-si3g5dih	222	19	Zika	Zika	NNP
cord-277355-si3g5dih	222	20	virus	virus	NN
cord-277355-si3g5dih	222	21	Crystal	Crystal	NNP
cord-277355-si3g5dih	222	22	structure	structure	NN
cord-277355-si3g5dih	222	23	of	of	IN
cord-277355-si3g5dih	222	24	the	the	DT
cord-277355-si3g5dih	222	25	Japanese	japanese	JJ
cord-277355-si3g5dih	222	26	encephalitis	encephalitis	RB
cord-277355-si3g5dih	222	27	virus	virus	NN
cord-277355-si3g5dih	222	28	capsid	capsid	NN
cord-277355-si3g5dih	222	29	protein	protein	NN
cord-277355-si3g5dih	222	30	Structural	structural	JJ
cord-277355-si3g5dih	222	31	insight	insight	NN
cord-277355-si3g5dih	222	32	into	into	IN
cord-277355-si3g5dih	222	33	the	the	DT
cord-277355-si3g5dih	222	34	Zika	Zika	NNP
cord-277355-si3g5dih	222	35	virus	virus	NN
cord-277355-si3g5dih	222	36	capsid	capsid	NN
cord-277355-si3g5dih	222	37	encapsulating	encapsulate	VBG
cord-277355-si3g5dih	222	38	the	the	DT
cord-277355-si3g5dih	222	39	viral	viral	JJ
cord-277355-si3g5dih	222	40	genome	genome	NN
cord-277355-si3g5dih	222	41	Dengue	dengue	NN
cord-277355-si3g5dih	222	42	virus	virus	NN
cord-277355-si3g5dih	222	43	capsid	capsid	NN
cord-277355-si3g5dih	222	44	protein	protein	NN
cord-277355-si3g5dih	222	45	usurps	usurp	VBZ
cord-277355-si3g5dih	222	46	lipid	lipid	NN
cord-277355-si3g5dih	222	47	droplets	droplet	NNS
cord-277355-si3g5dih	222	48	for	for	IN
cord-277355-si3g5dih	222	49	viral	viral	JJ
cord-277355-si3g5dih	222	50	particle	particle	NN
cord-277355-si3g5dih	222	51	formation	formation	NN
cord-277355-si3g5dih	222	52	Maintenance	maintenance	NN
cord-277355-si3g5dih	222	53	of	of	IN
cord-277355-si3g5dih	222	54	dimer	dimer	NN
cord-277355-si3g5dih	222	55	conformation	conformation	NN
cord-277355-si3g5dih	222	56	by	by	IN
cord-277355-si3g5dih	223	1	the	the	DT
cord-277355-si3g5dih	223	2	dengue	dengue	NN
cord-277355-si3g5dih	223	3	virus	virus	NN
cord-277355-si3g5dih	223	4	core	core	NN
cord-277355-si3g5dih	223	5	protein	protein	NN
cord-277355-si3g5dih	223	6	alpha	alpha	NN
cord-277355-si3g5dih	223	7	4-alpha	4-alpha	CD
cord-277355-si3g5dih	223	8	4'=	4'=	CD
cord-277355-si3g5dih	223	9	helix	helix	NN
cord-277355-si3g5dih	223	10	pair	pair	NN
cord-277355-si3g5dih	223	11	is	be	VBZ
cord-277355-si3g5dih	223	12	critical	critical	JJ
cord-277355-si3g5dih	223	13	for	for	IN
cord-277355-si3g5dih	223	14	nucleocapsid	nucleocapsid	NNP
cord-277355-si3g5dih	223	15	formation	formation	NN
cord-277355-si3g5dih	223	16	and	and	CC
cord-277355-si3g5dih	223	17	virus	virus	NN
cord-277355-si3g5dih	223	18	production	production	NN
cord-277355-si3g5dih	223	19	Partial	partial	JJ
cord-277355-si3g5dih	223	20	intrinsic	intrinsic	JJ
cord-277355-si3g5dih	223	21	disorder	disorder	NN
cord-277355-si3g5dih	223	22	governs	govern	VBZ
cord-277355-si3g5dih	223	23	the	the	DT
cord-277355-si3g5dih	223	24	dengue	dengue	NN
cord-277355-si3g5dih	223	25	capsid	capsid	NN
cord-277355-si3g5dih	223	26	protein	protein	NN
cord-277355-si3g5dih	223	27	conformational	conformational	NN
cord-277355-si3g5dih	223	28	ensemble	ensemble	NN
cord-277355-si3g5dih	223	29	Flavivirus	Flavivirus	NNP
cord-277355-si3g5dih	223	30	immunization	immunization	NN
cord-277355-si3g5dih	223	31	with	with	IN
cord-277355-si3g5dih	223	32	capsid	capsid	NN
cord-277355-si3g5dih	223	33	-	-	HYPH
cord-277355-si3g5dih	223	34	deletion	deletion	NN
cord-277355-si3g5dih	223	35	mutants	mutant	NNS
cord-277355-si3g5dih	223	36	:	:	:
cord-277355-si3g5dih	223	37	basics	basic	NNS
cord-277355-si3g5dih	223	38	,	,	,
cord-277355-si3g5dih	223	39	benefits	benefit	NNS
cord-277355-si3g5dih	223	40	,	,	,
cord-277355-si3g5dih	223	41	and	and	CC
cord-277355-si3g5dih	223	42	barriers	barrier	NNS
cord-277355-si3g5dih	223	43	Capsid	Capsid	NNP
cord-277355-si3g5dih	223	44	protein	protein	NN
cord-277355-si3g5dih	223	45	C	c	NN
cord-277355-si3g5dih	223	46	of	of	IN
cord-277355-si3g5dih	223	47	tick	tick	NN
cord-277355-si3g5dih	223	48	-	-	HYPH
cord-277355-si3g5dih	223	49	borne	bear	VBN
cord-277355-si3g5dih	223	50	encephalitis	encephalitis	JJ
cord-277355-si3g5dih	223	51	virus	virus	NN
cord-277355-si3g5dih	223	52	tolerates	tolerate	VBZ
cord-277355-si3g5dih	223	53	large	large	JJ
cord-277355-si3g5dih	223	54	internal	internal	JJ
cord-277355-si3g5dih	223	55	deletions	deletion	NNS
cord-277355-si3g5dih	223	56	and	and	CC
cord-277355-si3g5dih	223	57	is	be	VBZ
cord-277355-si3g5dih	223	58	a	a	DT
cord-277355-si3g5dih	223	59	favorable	favorable	JJ
cord-277355-si3g5dih	223	60	target	target	NN
cord-277355-si3g5dih	223	61	for	for	IN
cord-277355-si3g5dih	223	62	attenuation	attenuation	NN
cord-277355-si3g5dih	223	63	of	of	IN
cord-277355-si3g5dih	223	64	virulence	virulence	NN
cord-277355-si3g5dih	223	65	Mimicking	mimic	VBG
cord-277355-si3g5dih	223	66	live	live	VB
cord-277355-si3g5dih	223	67	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	223	68	immunization	immunization	NN
cord-277355-si3g5dih	223	69	with	with	IN
cord-277355-si3g5dih	223	70	a	a	DT
cord-277355-si3g5dih	223	71	noninfectious	noninfectious	JJ
cord-277355-si3g5dih	223	72	RNA	RNA	NNP
cord-277355-si3g5dih	223	73	vaccine	vaccine	NN
cord-277355-si3g5dih	223	74	Functional	functional	JJ
cord-277355-si3g5dih	223	75	requirements	requirement	NNS
cord-277355-si3g5dih	223	76	of	of	IN
cord-277355-si3g5dih	223	77	the	the	DT
cord-277355-si3g5dih	223	78	yellow	yellow	JJ
cord-277355-si3g5dih	223	79	fever	fever	NNP
cord-277355-si3g5dih	223	80	virus	virus	NN
cord-277355-si3g5dih	223	81	capsid	capsid	NN
cord-277355-si3g5dih	223	82	protein	protein	NN
cord-277355-si3g5dih	223	83	Helices	Helices	NNP
cord-277355-si3g5dih	223	84	alpha	alpha	NN
cord-277355-si3g5dih	223	85	2	2	CD
cord-277355-si3g5dih	223	86	and	and	CC
cord-277355-si3g5dih	223	87	alpha	alpha	NN
cord-277355-si3g5dih	223	88	3	3	CD
cord-277355-si3g5dih	223	89	of	of	IN
cord-277355-si3g5dih	223	90	west	west	NNP
cord-277355-si3g5dih	223	91	Nile	Nile	NNP
cord-277355-si3g5dih	223	92	virus	virus	NN
cord-277355-si3g5dih	223	93	capsid	capsid	NN
cord-277355-si3g5dih	223	94	protein	protein	NN
cord-277355-si3g5dih	223	95	are	be	VBP
cord-277355-si3g5dih	223	96	dispensable	dispensable	JJ
cord-277355-si3g5dih	223	97	for	for	IN
cord-277355-si3g5dih	223	98	assembly	assembly	NN
cord-277355-si3g5dih	223	99	of	of	IN
cord-277355-si3g5dih	223	100	infectious	infectious	JJ
cord-277355-si3g5dih	223	101	virions	virion	NNS
cord-277355-si3g5dih	224	1	NS2B-3	NS2B-3	NNP
cord-277355-si3g5dih	224	2	proteinasemediated	proteinasemediate	VBD
cord-277355-si3g5dih	224	3	processing	processing	NN
cord-277355-si3g5dih	224	4	in	in	IN
cord-277355-si3g5dih	224	5	the	the	DT
cord-277355-si3g5dih	224	6	yellow	yellow	JJ
cord-277355-si3g5dih	224	7	fever	fever	NNP
cord-277355-si3g5dih	224	8	virus	virus	NN
cord-277355-si3g5dih	224	9	structural	structural	JJ
cord-277355-si3g5dih	224	10	region	region	NN
cord-277355-si3g5dih	224	11	:	:	:
cord-277355-si3g5dih	224	12	in	in	IN
cord-277355-si3g5dih	224	13	vitro	vitro	FW
cord-277355-si3g5dih	224	14	and	and	CC
cord-277355-si3g5dih	224	15	in	in	IN
cord-277355-si3g5dih	224	16	vivo	vivo	NNP
cord-277355-si3g5dih	224	17	studies	study	NNS
cord-277355-si3g5dih	225	1	Signal	signal	NN
cord-277355-si3g5dih	225	2	peptidase	peptidase	NN
cord-277355-si3g5dih	225	3	cleavage	cleavage	NN
cord-277355-si3g5dih	225	4	at	at	IN
cord-277355-si3g5dih	225	5	the	the	DT
cord-277355-si3g5dih	225	6	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	225	7	C	C	NNP
cord-277355-si3g5dih	225	8	-	-	HYPH
cord-277355-si3g5dih	225	9	prM	prm	JJ
cord-277355-si3g5dih	225	10	junction	junction	NN
cord-277355-si3g5dih	225	11	:	:	:
cord-277355-si3g5dih	225	12	dependence	dependence	NN
cord-277355-si3g5dih	225	13	on	on	IN
cord-277355-si3g5dih	225	14	the	the	DT
cord-277355-si3g5dih	225	15	viral	viral	JJ
cord-277355-si3g5dih	225	16	NS2B-3	NS2B-3	NNP
cord-277355-si3g5dih	225	17	protease	protease	NN
cord-277355-si3g5dih	225	18	for	for	IN
cord-277355-si3g5dih	225	19	efficient	efficient	JJ
cord-277355-si3g5dih	225	20	processing	processing	NN
cord-277355-si3g5dih	225	21	requires	require	VBZ
cord-277355-si3g5dih	225	22	determinants	determinant	NNS
cord-277355-si3g5dih	225	23	in	in	IN
cord-277355-si3g5dih	225	24	C	C	NNP
cord-277355-si3g5dih	225	25	,	,	,
cord-277355-si3g5dih	225	26	the	the	DT
cord-277355-si3g5dih	225	27	signal	signal	NN
cord-277355-si3g5dih	225	28	peptide	peptide	NN
cord-277355-si3g5dih	225	29	,	,	,
cord-277355-si3g5dih	225	30	and	and	CC
cord-277355-si3g5dih	225	31	prM	prM	NNP
cord-277355-si3g5dih	225	32	Mutagenesis	Mutagenesis	NNP
cord-277355-si3g5dih	225	33	of	of	IN
cord-277355-si3g5dih	225	34	the	the	DT
cord-277355-si3g5dih	225	35	NS2B	NS2B	NNP
cord-277355-si3g5dih	225	36	-	-	HYPH
cord-277355-si3g5dih	225	37	NS3-mediated	ns3-mediate	VBN
cord-277355-si3g5dih	225	38	cleavage	cleavage	NN
cord-277355-si3g5dih	225	39	site	site	NN
cord-277355-si3g5dih	225	40	in	in	IN
cord-277355-si3g5dih	225	41	the	the	DT
cord-277355-si3g5dih	225	42	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	225	43	capsid	capsid	NN
cord-277355-si3g5dih	225	44	protein	protein	NN
cord-277355-si3g5dih	225	45	demonstrates	demonstrate	VBZ
cord-277355-si3g5dih	225	46	a	a	DT
cord-277355-si3g5dih	225	47	requirement	requirement	NN
cord-277355-si3g5dih	225	48	for	for	IN
cord-277355-si3g5dih	225	49	coordinated	coordinated	JJ
cord-277355-si3g5dih	225	50	processing	processing	NN
cord-277355-si3g5dih	225	51	Mutagenesis	Mutagenesis	NNP
cord-277355-si3g5dih	225	52	of	of	IN
cord-277355-si3g5dih	225	53	the	the	DT
cord-277355-si3g5dih	225	54	signal	signal	JJ
cord-277355-si3g5dih	225	55	sequence	sequence	NN
cord-277355-si3g5dih	225	56	of	of	IN
cord-277355-si3g5dih	225	57	yellow	yellow	JJ
cord-277355-si3g5dih	225	58	fever	fever	NNP
cord-277355-si3g5dih	225	59	virus	virus	NN
cord-277355-si3g5dih	225	60	prM	prm	JJ
cord-277355-si3g5dih	225	61	protein	protein	NN
cord-277355-si3g5dih	225	62	:	:	:
cord-277355-si3g5dih	225	63	enhancement	enhancement	NN
cord-277355-si3g5dih	225	64	of	of	IN
cord-277355-si3g5dih	225	65	signalase	signalase	NN
cord-277355-si3g5dih	225	66	cleavage	cleavage	NN
cord-277355-si3g5dih	226	1	In	in	IN
cord-277355-si3g5dih	226	2	vitro	vitro	FW
cord-277355-si3g5dih	226	3	is	be	VBZ
cord-277355-si3g5dih	226	4	lethal	lethal	JJ
cord-277355-si3g5dih	226	5	for	for	IN
cord-277355-si3g5dih	226	6	virus	virus	NN
cord-277355-si3g5dih	226	7	production	production	NN
cord-277355-si3g5dih	226	8	Inefficient	inefficient	JJ
cord-277355-si3g5dih	226	9	signalase	signalase	NN
cord-277355-si3g5dih	226	10	cleavage	cleavage	NN
cord-277355-si3g5dih	226	11	promotes	promote	VBZ
cord-277355-si3g5dih	226	12	efficient	efficient	JJ
cord-277355-si3g5dih	226	13	nucleocapsid	nucleocapsid	NN
cord-277355-si3g5dih	226	14	incorporation	incorporation	NN
cord-277355-si3g5dih	226	15	into	into	IN
cord-277355-si3g5dih	226	16	budding	bud	VBG
cord-277355-si3g5dih	226	17	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	226	18	membranes	membrane	NNS
cord-277355-si3g5dih	227	1	A	a	DT
cord-277355-si3g5dih	227	2	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	227	3	signal	signal	NN
cord-277355-si3g5dih	227	4	peptide	peptide	NN
cord-277355-si3g5dih	227	5	balances	balance	VBZ
cord-277355-si3g5dih	227	6	the	the	DT
cord-277355-si3g5dih	227	7	catalytic	catalytic	JJ
cord-277355-si3g5dih	227	8	activity	activity	NN
cord-277355-si3g5dih	227	9	of	of	IN
cord-277355-si3g5dih	227	10	two	two	CD
cord-277355-si3g5dih	227	11	proteases	protease	NNS
cord-277355-si3g5dih	227	12	and	and	CC
cord-277355-si3g5dih	227	13	thereby	thereby	RB
cord-277355-si3g5dih	227	14	facilitates	facilitate	VBZ
cord-277355-si3g5dih	227	15	virus	virus	NN
cord-277355-si3g5dih	227	16	morphogenesis	morphogenesis	NN
cord-277355-si3g5dih	227	17	Role	role	NN
cord-277355-si3g5dih	227	18	of	of	IN
cord-277355-si3g5dih	227	19	capsid	capsid	NN
cord-277355-si3g5dih	227	20	anchor	anchor	NN
cord-277355-si3g5dih	227	21	in	in	IN
cord-277355-si3g5dih	227	22	the	the	DT
cord-277355-si3g5dih	227	23	morphogenesis	morphogenesis	NN
cord-277355-si3g5dih	227	24	of	of	IN
cord-277355-si3g5dih	227	25	Zika	Zika	NNP
cord-277355-si3g5dih	227	26	virus	virus	NN
cord-277355-si3g5dih	227	27	Increased	increase	VBN
cord-277355-si3g5dih	227	28	expression	expression	NN
cord-277355-si3g5dih	227	29	of	of	IN
cord-277355-si3g5dih	227	30	capsid	capsid	NN
cord-277355-si3g5dih	227	31	protein	protein	NN
cord-277355-si3g5dih	227	32	in	in	IN
cord-277355-si3g5dih	227	33	trans	trans	NNP
cord-277355-si3g5dih	227	34	enhances	enhance	VBZ
cord-277355-si3g5dih	227	35	production	production	NN
cord-277355-si3g5dih	227	36	of	of	IN
cord-277355-si3g5dih	227	37	singleround	singleround	JJ
cord-277355-si3g5dih	227	38	infectious	infectious	JJ
cord-277355-si3g5dih	227	39	particles	particle	NNS
cord-277355-si3g5dih	227	40	by	by	IN
cord-277355-si3g5dih	227	41	West	West	NNP
cord-277355-si3g5dih	227	42	Nile	Nile	NNP
cord-277355-si3g5dih	227	43	virus	virus	NN
cord-277355-si3g5dih	227	44	DNA	dna	NN
cord-277355-si3g5dih	227	45	vaccine	vaccine	NN
cord-277355-si3g5dih	227	46	candidate	candidate	NN
cord-277355-si3g5dih	227	47	Production	production	NN
cord-277355-si3g5dih	227	48	and	and	CC
cord-277355-si3g5dih	227	49	characterization	characterization	NN
cord-277355-si3g5dih	227	50	of	of	IN
cord-277355-si3g5dih	227	51	vaccines	vaccine	NNS
cord-277355-si3g5dih	227	52	based	base	VBN
cord-277355-si3g5dih	227	53	on	on	IN
cord-277355-si3g5dih	227	54	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	227	55	defective	defective	JJ
cord-277355-si3g5dih	227	56	in	in	IN
cord-277355-si3g5dih	227	57	replication	replication	NN
cord-277355-si3g5dih	228	1	A	a	DT
cord-277355-si3g5dih	228	2	single	single	JJ
cord-277355-si3g5dih	228	3	-	-	HYPH
cord-277355-si3g5dih	228	4	dose	dose	NN
cord-277355-si3g5dih	228	5	live	live	RB
cord-277355-si3g5dih	228	6	-	-	HYPH
cord-277355-si3g5dih	228	7	attenuated	attenuate	VBN
cord-277355-si3g5dih	228	8	Zika	Zika	NNP
cord-277355-si3g5dih	228	9	virus	virus	NN
cord-277355-si3g5dih	228	10	vaccine	vaccine	NN
cord-277355-si3g5dih	228	11	with	with	IN
cord-277355-si3g5dih	228	12	controlled	control	VBN
cord-277355-si3g5dih	228	13	infection	infection	NN
cord-277355-si3g5dih	228	14	rounds	round	NNS
cord-277355-si3g5dih	228	15	that	that	WDT
cord-277355-si3g5dih	228	16	protects	protect	VBZ
cord-277355-si3g5dih	228	17	against	against	IN
cord-277355-si3g5dih	228	18	vertical	vertical	JJ
cord-277355-si3g5dih	228	19	transmission	transmission	NN
cord-277355-si3g5dih	229	1	e485	e485	NNP
cord-277355-si3g5dih	229	2	DENV2	DENV2	NNP
cord-277355-si3g5dih	229	3	Pseudoviral	Pseudoviral	NNP
cord-277355-si3g5dih	229	4	Particles	Particles	NNPS
cord-277355-si3g5dih	229	5	with	with	IN
cord-277355-si3g5dih	229	6	Unprocessed	unprocessed	JJ
cord-277355-si3g5dih	229	7	Capsid	Capsid	NNP
cord-277355-si3g5dih	229	8	Protein	Protein	NNP
cord-277355-si3g5dih	229	9	Are	be	VBP
cord-277355-si3g5dih	229	10	Assembled	assemble	VBN
cord-277355-si3g5dih	229	11	and	and	CC
cord-277355-si3g5dih	229	12	Infectious	Infectious	NNP
cord-277355-si3g5dih	229	13	Viral	Viral	NNP
cord-277355-si3g5dih	229	14	RNA	RNA	NNP
cord-277355-si3g5dih	229	15	switch	switch	NN
cord-277355-si3g5dih	229	16	mediates	mediate	VBZ
cord-277355-si3g5dih	229	17	the	the	DT
cord-277355-si3g5dih	229	18	dynamic	dynamic	JJ
cord-277355-si3g5dih	229	19	control	control	NN
cord-277355-si3g5dih	229	20	of	of	IN
cord-277355-si3g5dih	229	21	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	229	22	replicase	replicase	NNP
cord-277355-si3g5dih	229	23	recruitment	recruitment	NNP
cord-277355-si3g5dih	229	24	by	by	IN
cord-277355-si3g5dih	229	25	genome	genome	NN
cord-277355-si3g5dih	229	26	cyclization	cyclization	NN
cord-277355-si3g5dih	230	1	Long	long	JJ
cord-277355-si3g5dih	230	2	-	-	HYPH
cord-277355-si3g5dih	230	3	range	range	NNP
cord-277355-si3g5dih	230	4	RNA	RNA	NNP
cord-277355-si3g5dih	230	5	-	-	HYPH
cord-277355-si3g5dih	230	6	RNA	RNA	NNP
cord-277355-si3g5dih	230	7	interactions	interaction	NNS
cord-277355-si3g5dih	230	8	circularize	circularize	VBP
cord-277355-si3g5dih	230	9	the	the	DT
cord-277355-si3g5dih	230	10	dengue	dengue	NN
cord-277355-si3g5dih	230	11	virus	virus	NN
cord-277355-si3g5dih	230	12	genome	genome	NN
cord-277355-si3g5dih	230	13	Essential	essential	JJ
cord-277355-si3g5dih	230	14	role	role	NN
cord-277355-si3g5dih	230	15	of	of	IN
cord-277355-si3g5dih	230	16	cyclization	cyclization	NN
cord-277355-si3g5dih	230	17	sequences	sequence	NNS
cord-277355-si3g5dih	230	18	in	in	IN
cord-277355-si3g5dih	230	19	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	230	20	RNA	RNA	NNP
cord-277355-si3g5dih	230	21	replication	replication	NN
cord-277355-si3g5dih	231	1	The	the	DT
cord-277355-si3g5dih	231	2	5	5	CD
cord-277355-si3g5dih	231	3	'	'	''
cord-277355-si3g5dih	231	4	and	and	CC
cord-277355-si3g5dih	231	5	3	3	CD
cord-277355-si3g5dih	231	6	'	'	''
cord-277355-si3g5dih	231	7	downstream	downstream	JJ
cord-277355-si3g5dih	231	8	AUG	AUG	NNP
cord-277355-si3g5dih	231	9	region	region	NN
cord-277355-si3g5dih	231	10	elements	element	NNS
cord-277355-si3g5dih	231	11	are	be	VBP
cord-277355-si3g5dih	231	12	required	require	VBN
cord-277355-si3g5dih	231	13	for	for	IN
cord-277355-si3g5dih	232	1	mosquito	mosquito	NN
cord-277355-si3g5dih	232	2	-	-	HYPH
cord-277355-si3g5dih	232	3	borne	bear	VBN
cord-277355-si3g5dih	232	4	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	232	5	RNA	RNA	NNP
cord-277355-si3g5dih	232	6	replication	replication	NN
cord-277355-si3g5dih	232	7	RNA	RNA	NNP
cord-277355-si3g5dih	232	8	secondary	secondary	JJ
cord-277355-si3g5dih	232	9	structure	structure	NN
cord-277355-si3g5dih	232	10	in	in	IN
cord-277355-si3g5dih	232	11	the	the	DT
cord-277355-si3g5dih	232	12	coding	code	VBG
cord-277355-si3g5dih	232	13	region	region	NN
cord-277355-si3g5dih	232	14	of	of	IN
cord-277355-si3g5dih	232	15	dengue	dengue	NN
cord-277355-si3g5dih	232	16	virus	virus	NN
cord-277355-si3g5dih	232	17	type	type	NN
cord-277355-si3g5dih	232	18	2	2	CD
cord-277355-si3g5dih	232	19	directs	direct	VBZ
cord-277355-si3g5dih	232	20	translation	translation	NN
cord-277355-si3g5dih	232	21	start	start	NN
cord-277355-si3g5dih	232	22	codon	codon	NN
cord-277355-si3g5dih	232	23	selection	selection	NN
cord-277355-si3g5dih	232	24	and	and	CC
cord-277355-si3g5dih	232	25	is	be	VBZ
cord-277355-si3g5dih	232	26	required	require	VBN
cord-277355-si3g5dih	232	27	for	for	IN
cord-277355-si3g5dih	232	28	viral	viral	JJ
cord-277355-si3g5dih	232	29	replication	replication	NN
cord-277355-si3g5dih	233	1	The	the	DT
cord-277355-si3g5dih	233	2	capsid	capsid	RB
cord-277355-si3g5dih	233	3	-	-	HYPH
cord-277355-si3g5dih	233	4	coding	code	VBG
cord-277355-si3g5dih	233	5	region	region	NN
cord-277355-si3g5dih	233	6	hairpin	hairpin	NN
cord-277355-si3g5dih	233	7	element	element	NN
cord-277355-si3g5dih	233	8	(	(	-LRB-
cord-277355-si3g5dih	233	9	cHP	cHP	NNP
cord-277355-si3g5dih	233	10	)	)	-RRB-
cord-277355-si3g5dih	233	11	is	be	VBZ
cord-277355-si3g5dih	233	12	a	a	DT
cord-277355-si3g5dih	233	13	critical	critical	JJ
cord-277355-si3g5dih	233	14	determinant	determinant	NN
cord-277355-si3g5dih	233	15	of	of	IN
cord-277355-si3g5dih	233	16	dengue	dengue	NN
cord-277355-si3g5dih	233	17	virus	virus	NN
cord-277355-si3g5dih	233	18	and	and	CC
cord-277355-si3g5dih	233	19	West	West	NNP
cord-277355-si3g5dih	233	20	Nile	Nile	NNP
cord-277355-si3g5dih	233	21	virus	virus	NN
cord-277355-si3g5dih	233	22	RNA	RNA	NNP
cord-277355-si3g5dih	233	23	synthesis	synthesis	NN
cord-277355-si3g5dih	233	24	Novel	Novel	NNP
cord-277355-si3g5dih	233	25	cis	cis	NNP
cord-277355-si3g5dih	233	26	-	-	HYPH
cord-277355-si3g5dih	233	27	Acting	Acting	NNP
cord-277355-si3g5dih	233	28	element	element	NN
cord-277355-si3g5dih	233	29	within	within	IN
cord-277355-si3g5dih	233	30	the	the	DT
cord-277355-si3g5dih	233	31	capsid	capsid	RB
cord-277355-si3g5dih	233	32	-	-	HYPH
cord-277355-si3g5dih	233	33	coding	code	VBG
cord-277355-si3g5dih	233	34	region	region	NN
cord-277355-si3g5dih	233	35	enhances	enhance	VBZ
cord-277355-si3g5dih	233	36	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	233	37	viral	viral	NNP
cord-277355-si3g5dih	233	38	-	-	HYPH
cord-277355-si3g5dih	233	39	RNA	rna	NN
cord-277355-si3g5dih	233	40	replication	replication	NN
cord-277355-si3g5dih	233	41	by	by	IN
cord-277355-si3g5dih	233	42	regulating	regulate	VBG
cord-277355-si3g5dih	233	43	genome	genome	NN
cord-277355-si3g5dih	233	44	cyclization	cyclization	NN
cord-277355-si3g5dih	234	1	Overlapping	overlap	VBG
cord-277355-si3g5dih	234	2	local	local	JJ
cord-277355-si3g5dih	234	3	and	and	CC
cord-277355-si3g5dih	234	4	long	long	JJ
cord-277355-si3g5dih	234	5	-	-	HYPH
cord-277355-si3g5dih	234	6	range	range	NN
cord-277355-si3g5dih	234	7	RNA	RNA	NNP
cord-277355-si3g5dih	234	8	-	-	HYPH
cord-277355-si3g5dih	234	9	RNA	RNA	NNP
cord-277355-si3g5dih	234	10	interactions	interaction	NNS
cord-277355-si3g5dih	234	11	modulate	modulate	VBP
cord-277355-si3g5dih	234	12	dengue	dengue	NN
cord-277355-si3g5dih	234	13	virus	virus	NN
cord-277355-si3g5dih	234	14	genome	genome	NN
cord-277355-si3g5dih	234	15	cyclization	cyclization	NN
cord-277355-si3g5dih	234	16	and	and	CC
cord-277355-si3g5dih	234	17	replication	replication	NN
cord-277355-si3g5dih	234	18	Composition	composition	NN
cord-277355-si3g5dih	234	19	of	of	IN
cord-277355-si3g5dih	234	20	the	the	DT
cord-277355-si3g5dih	234	21	sequence	sequence	NN
cord-277355-si3g5dih	234	22	downstream	downstream	RB
cord-277355-si3g5dih	234	23	of	of	IN
cord-277355-si3g5dih	234	24	the	the	DT
cord-277355-si3g5dih	234	25	dengue	dengue	NN
cord-277355-si3g5dih	234	26	virus	virus	NN
cord-277355-si3g5dih	234	27	5	5	CD
cord-277355-si3g5dih	234	28	'	'	''
cord-277355-si3g5dih	234	29	cyclization	cyclization	NN
cord-277355-si3g5dih	234	30	sequence	sequence	NN
cord-277355-si3g5dih	234	31	(	(	-LRB-
cord-277355-si3g5dih	234	32	dCS	dCS	NNP
cord-277355-si3g5dih	234	33	)	)	-RRB-
cord-277355-si3g5dih	234	34	affects	affect	VBZ
cord-277355-si3g5dih	234	35	viral	viral	JJ
cord-277355-si3g5dih	234	36	RNA	RNA	NNP
cord-277355-si3g5dih	234	37	replication	replication	NN
cord-277355-si3g5dih	235	1	Intracellular	Intracellular	NNP
cord-277355-si3g5dih	235	2	localization	localization	NN
cord-277355-si3g5dih	235	3	and	and	CC
cord-277355-si3g5dih	235	4	determination	determination	NN
cord-277355-si3g5dih	235	5	of	of	IN
cord-277355-si3g5dih	235	6	a	a	DT
cord-277355-si3g5dih	235	7	nuclear	nuclear	JJ
cord-277355-si3g5dih	235	8	localization	localization	NN
cord-277355-si3g5dih	235	9	signal	signal	NN
cord-277355-si3g5dih	235	10	of	of	IN
cord-277355-si3g5dih	235	11	the	the	DT
cord-277355-si3g5dih	235	12	core	core	NN
cord-277355-si3g5dih	235	13	protein	protein	NN
cord-277355-si3g5dih	235	14	of	of	IN
cord-277355-si3g5dih	235	15	dengue	dengue	NN
cord-277355-si3g5dih	235	16	virus	virus	NN
cord-277355-si3g5dih	235	17	Nuclear	nuclear	JJ
cord-277355-si3g5dih	235	18	localization	localization	NN
cord-277355-si3g5dih	235	19	of	of	IN
cord-277355-si3g5dih	235	20	Japanese	japanese	JJ
cord-277355-si3g5dih	235	21	encephalitis	encephalitis	RB
cord-277355-si3g5dih	235	22	virus	virus	NN
cord-277355-si3g5dih	235	23	core	core	NN
cord-277355-si3g5dih	235	24	protein	protein	NN
cord-277355-si3g5dih	235	25	enhances	enhance	VBZ
cord-277355-si3g5dih	235	26	viral	viral	JJ
cord-277355-si3g5dih	235	27	replication	replication	NN
cord-277355-si3g5dih	235	28	Specific	specific	JJ
cord-277355-si3g5dih	235	29	interaction	interaction	NN
cord-277355-si3g5dih	235	30	of	of	IN
cord-277355-si3g5dih	235	31	capsid	capsid	NN
cord-277355-si3g5dih	235	32	protein	protein	NN
cord-277355-si3g5dih	235	33	and	and	CC
cord-277355-si3g5dih	236	1	importin	importin	JJ
cord-277355-si3g5dih	236	2	-	-	HYPH
cord-277355-si3g5dih	236	3	alpha	alpha	NN
cord-277355-si3g5dih	236	4	/	/	SYM
cord-277355-si3g5dih	236	5	beta	beta	NN
cord-277355-si3g5dih	236	6	influences	influence	NNS
cord-277355-si3g5dih	236	7	West	West	NNP
cord-277355-si3g5dih	236	8	Nile	Nile	NNP
cord-277355-si3g5dih	236	9	virus	virus	NN
cord-277355-si3g5dih	236	10	production	production	NN
cord-277355-si3g5dih	236	11	Detection	detection	NN
cord-277355-si3g5dih	236	12	of	of	IN
cord-277355-si3g5dih	236	13	dengue	dengue	NN
cord-277355-si3g5dih	236	14	4	4	CD
cord-277355-si3g5dih	236	15	virus	virus	NN
cord-277355-si3g5dih	236	16	core	core	NN
cord-277355-si3g5dih	236	17	protein	protein	NN
cord-277355-si3g5dih	236	18	in	in	IN
cord-277355-si3g5dih	236	19	the	the	DT
cord-277355-si3g5dih	236	20	nucleus	nucleus	NN
cord-277355-si3g5dih	236	21	.	.	.
cord-277355-si3g5dih	237	1	I.	I.	NNP
cord-277355-si3g5dih	237	2	A	a	DT
cord-277355-si3g5dih	237	3	monoclonal	monoclonal	JJ
cord-277355-si3g5dih	237	4	antibody	antibody	NN
cord-277355-si3g5dih	237	5	to	to	IN
cord-277355-si3g5dih	237	6	dengue	dengue	NN
cord-277355-si3g5dih	237	7	4	4	CD
cord-277355-si3g5dih	237	8	virus	virus	NN
cord-277355-si3g5dih	237	9	reacts	react	VBZ
cord-277355-si3g5dih	237	10	with	with	IN
cord-277355-si3g5dih	237	11	the	the	DT
cord-277355-si3g5dih	237	12	antigen	antigen	NN
cord-277355-si3g5dih	237	13	in	in	IN
cord-277355-si3g5dih	237	14	the	the	DT
cord-277355-si3g5dih	237	15	nucleus	nucleus	NN
cord-277355-si3g5dih	237	16	and	and	CC
cord-277355-si3g5dih	237	17	cytoplasm	cytoplasm	JJ
cord-277355-si3g5dih	237	18	Nuclear	nuclear	JJ
cord-277355-si3g5dih	237	19	localization	localization	NN
cord-277355-si3g5dih	237	20	of	of	IN
cord-277355-si3g5dih	237	21	dengue	dengue	NN
cord-277355-si3g5dih	237	22	2	2	CD
cord-277355-si3g5dih	237	23	virus	virus	NN
cord-277355-si3g5dih	237	24	core	core	NN
cord-277355-si3g5dih	237	25	protein	protein	NN
cord-277355-si3g5dih	237	26	detected	detect	VBD
cord-277355-si3g5dih	237	27	with	with	IN
cord-277355-si3g5dih	237	28	monoclonal	monoclonal	JJ
cord-277355-si3g5dih	237	29	antibodies	antibody	NNS
cord-277355-si3g5dih	237	30	Multiple	multiple	JJ
cord-277355-si3g5dih	237	31	regions	region	NNS
cord-277355-si3g5dih	237	32	in	in	IN
cord-277355-si3g5dih	237	33	dengue	dengue	NN
cord-277355-si3g5dih	237	34	virus	virus	NN
cord-277355-si3g5dih	237	35	capsid	capsid	NN
cord-277355-si3g5dih	237	36	protein	protein	NN
cord-277355-si3g5dih	237	37	contribute	contribute	VBP
cord-277355-si3g5dih	237	38	to	to	IN
cord-277355-si3g5dih	237	39	nuclear	nuclear	JJ
cord-277355-si3g5dih	237	40	localization	localization	NN
cord-277355-si3g5dih	237	41	during	during	IN
cord-277355-si3g5dih	237	42	virus	virus	NN
cord-277355-si3g5dih	237	43	infection	infection	NN
cord-277355-si3g5dih	237	44	Nucleolar	Nucleolar	NNP
cord-277355-si3g5dih	237	45	protein	protein	NN
cord-277355-si3g5dih	237	46	B23	B23	NNP
cord-277355-si3g5dih	237	47	interacts	interact	VBZ
cord-277355-si3g5dih	237	48	with	with	IN
cord-277355-si3g5dih	237	49	Japanese	japanese	JJ
cord-277355-si3g5dih	237	50	encephalitis	encephalitis	JJ
cord-277355-si3g5dih	237	51	virus	virus	NN
cord-277355-si3g5dih	237	52	core	core	NN
cord-277355-si3g5dih	237	53	protein	protein	NN
cord-277355-si3g5dih	237	54	and	and	CC
cord-277355-si3g5dih	237	55	participates	participate	VBZ
cord-277355-si3g5dih	237	56	in	in	IN
cord-277355-si3g5dih	237	57	viral	viral	JJ
cord-277355-si3g5dih	237	58	replication	replication	NN
cord-277355-si3g5dih	237	59	Functional	functional	JJ
cord-277355-si3g5dih	237	60	correlation	correlation	NN
cord-277355-si3g5dih	237	61	between	between	IN
cord-277355-si3g5dih	237	62	subcellular	subcellular	JJ
cord-277355-si3g5dih	237	63	localizations	localization	NNS
cord-277355-si3g5dih	237	64	of	of	IN
cord-277355-si3g5dih	237	65	Japanese	japanese	JJ
cord-277355-si3g5dih	237	66	encephalitis	encephalitis	RB
cord-277355-si3g5dih	237	67	virus	virus	NN
cord-277355-si3g5dih	237	68	capsid	capsid	NN
cord-277355-si3g5dih	237	69	protein	protein	NN
cord-277355-si3g5dih	237	70	and	and	CC
cord-277355-si3g5dih	237	71	virus	virus	NN
cord-277355-si3g5dih	237	72	production	production	NN
cord-277355-si3g5dih	238	1	The	the	DT
cord-277355-si3g5dih	238	2	disordered	disordered	JJ
cord-277355-si3g5dih	238	3	N	n	CD
cord-277355-si3g5dih	238	4	-	-	HYPH
cord-277355-si3g5dih	238	5	terminal	terminal	NN
cord-277355-si3g5dih	238	6	region	region	NN
cord-277355-si3g5dih	238	7	of	of	IN
cord-277355-si3g5dih	238	8	dengue	dengue	NN
cord-277355-si3g5dih	238	9	virus	virus	NN
cord-277355-si3g5dih	238	10	capsid	capsid	NN
cord-277355-si3g5dih	238	11	protein	protein	NN
cord-277355-si3g5dih	238	12	contains	contain	VBZ
cord-277355-si3g5dih	238	13	a	a	DT
cord-277355-si3g5dih	238	14	lipid	lipid	NN
cord-277355-si3g5dih	238	15	-	-	HYPH
cord-277355-si3g5dih	238	16	dropletbinding	dropletbinding	NN
cord-277355-si3g5dih	238	17	motif	motif	NN
cord-277355-si3g5dih	238	18	Isolation	isolation	NN
cord-277355-si3g5dih	238	19	of	of	IN
cord-277355-si3g5dih	238	20	capsid	capsid	NN
cord-277355-si3g5dih	238	21	protein	protein	NN
cord-277355-si3g5dih	238	22	dimers	dimer	NNS
cord-277355-si3g5dih	238	23	from	from	IN
cord-277355-si3g5dih	238	24	the	the	DT
cord-277355-si3g5dih	238	25	tick	tick	NN
cord-277355-si3g5dih	238	26	-	-	HYPH
cord-277355-si3g5dih	238	27	borne	bear	VBN
cord-277355-si3g5dih	238	28	encephalitis	encephalitis	RB
cord-277355-si3g5dih	238	29	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	238	30	and	and	CC
cord-277355-si3g5dih	238	31	in	in	IN
cord-277355-si3g5dih	238	32	vitro	vitro	FW
cord-277355-si3g5dih	238	33	assembly	assembly	NN
cord-277355-si3g5dih	238	34	of	of	IN
cord-277355-si3g5dih	238	35	capsid	capsid	NN
cord-277355-si3g5dih	238	36	-	-	HYPH
cord-277355-si3g5dih	238	37	like	like	JJ
cord-277355-si3g5dih	238	38	particles	particle	NNS
cord-277355-si3g5dih	238	39	Cryo	cryo	NN
cord-277355-si3g5dih	238	40	-	-	HYPH
cord-277355-si3g5dih	238	41	EM	EM	NNP
cord-277355-si3g5dih	238	42	structure	structure	NN
cord-277355-si3g5dih	238	43	of	of	IN
cord-277355-si3g5dih	238	44	the	the	DT
cord-277355-si3g5dih	238	45	mature	mature	JJ
cord-277355-si3g5dih	238	46	dengue	dengue	NN
cord-277355-si3g5dih	238	47	virus	virus	NN
cord-277355-si3g5dih	238	48	at	at	IN
cord-277355-si3g5dih	238	49	3.5-A	3.5-a	CD
cord-277355-si3g5dih	238	50	resolution	resolution	NN
cord-277355-si3g5dih	238	51	Structure	structure	NN
cord-277355-si3g5dih	238	52	of	of	IN
cord-277355-si3g5dih	238	53	the	the	DT
cord-277355-si3g5dih	238	54	immature	immature	JJ
cord-277355-si3g5dih	238	55	Zika	Zika	NNP
cord-277355-si3g5dih	238	56	virus	virus	NN
cord-277355-si3g5dih	238	57	at	at	IN
cord-277355-si3g5dih	238	58	9	9	CD
cord-277355-si3g5dih	239	1	A	a	DT
cord-277355-si3g5dih	239	2	resolution	resolution	NN
cord-277355-si3g5dih	239	3	Flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	239	4	have	have	VBP
cord-277355-si3g5dih	239	5	imperfect	imperfect	JJ
cord-277355-si3g5dih	239	6	icosahedral	icosahedral	JJ
cord-277355-si3g5dih	239	7	symmetry	symmetry	NN
cord-277355-si3g5dih	239	8	RNA	RNA	NNP
cord-277355-si3g5dih	239	9	binding	bind	VBG
cord-277355-si3g5dih	239	10	properties	property	NNS
cord-277355-si3g5dih	239	11	of	of	IN
cord-277355-si3g5dih	239	12	core	core	NN
cord-277355-si3g5dih	239	13	protein	protein	NN
cord-277355-si3g5dih	239	14	of	of	IN
cord-277355-si3g5dih	239	15	the	the	DT
cord-277355-si3g5dih	239	16	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	239	17	Kunjin	Kunjin	NNP
cord-277355-si3g5dih	239	18	Uncoupling	Uncoupling	NNP
cord-277355-si3g5dih	239	19	cis	cis	NNP
cord-277355-si3g5dih	239	20	-	-	HYPH
cord-277355-si3g5dih	239	21	Acting	Acting	NNP
cord-277355-si3g5dih	239	22	RNA	RNA	NNP
cord-277355-si3g5dih	239	23	elements	element	NNS
cord-277355-si3g5dih	239	24	from	from	IN
cord-277355-si3g5dih	239	25	coding	code	VBG
cord-277355-si3g5dih	239	26	sequences	sequence	NNS
cord-277355-si3g5dih	239	27	revealed	reveal	VBD
cord-277355-si3g5dih	239	28	a	a	DT
cord-277355-si3g5dih	239	29	requirement	requirement	NN
cord-277355-si3g5dih	239	30	of	of	IN
cord-277355-si3g5dih	239	31	the	the	DT
cord-277355-si3g5dih	239	32	Nterminal	Nterminal	NNP
cord-277355-si3g5dih	239	33	region	region	NN
cord-277355-si3g5dih	239	34	of	of	IN
cord-277355-si3g5dih	239	35	dengue	dengue	NN
cord-277355-si3g5dih	239	36	virus	virus	NN
cord-277355-si3g5dih	239	37	capsid	capsid	NN
cord-277355-si3g5dih	239	38	protein	protein	NN
cord-277355-si3g5dih	239	39	in	in	IN
cord-277355-si3g5dih	239	40	virus	virus	NN
cord-277355-si3g5dih	239	41	particle	particle	NN
cord-277355-si3g5dih	239	42	formation	formation	NN
cord-277355-si3g5dih	239	43	Genome	genome	NN
cord-277355-si3g5dih	239	44	-	-	HYPH
cord-277355-si3g5dih	239	45	wide	wide	JJ
cord-277355-si3g5dih	239	46	Associations	association	NNS
cord-277355-si3g5dih	239	47	of	of	IN
cord-277355-si3g5dih	239	48	Flavivirus	Flavivirus	NNP
cord-277355-si3g5dih	239	49	Capsid	Capsid	NNP
cord-277355-si3g5dih	239	50	Proteins	protein	NNS
cord-277355-si3g5dih	239	51	.	.	.
cord-277355-si3g5dih	240	1	bioRxiv	biorxiv	RB
cord-277355-si3g5dih	241	1	In	in	IN
cord-277355-si3g5dih	241	2	vitro	vitro	FW
cord-277355-si3g5dih	241	3	assembly	assembly	NN
cord-277355-si3g5dih	241	4	of	of	IN
cord-277355-si3g5dih	241	5	nucleocapsid	nucleocapsid	NN
cord-277355-si3g5dih	241	6	-	-	HYPH
cord-277355-si3g5dih	241	7	like	like	JJ
cord-277355-si3g5dih	241	8	particles	particle	NNS
cord-277355-si3g5dih	241	9	from	from	IN
cord-277355-si3g5dih	241	10	purified	purify	VBN
cord-277355-si3g5dih	241	11	recombinant	recombinant	JJ
cord-277355-si3g5dih	241	12	capsid	capsid	NN
cord-277355-si3g5dih	241	13	protein	protein	NN
cord-277355-si3g5dih	241	14	of	of	IN
cord-277355-si3g5dih	241	15	dengue-2	dengue-2	NNP
cord-277355-si3g5dih	241	16	virus	virus	NN
cord-277355-si3g5dih	241	17	Composition	composition	NN
cord-277355-si3g5dih	241	18	and	and	CC
cord-277355-si3g5dih	241	19	three	three	CD
cord-277355-si3g5dih	241	20	-	-	HYPH
cord-277355-si3g5dih	241	21	dimensional	dimensional	JJ
cord-277355-si3g5dih	241	22	architecture	architecture	NN
cord-277355-si3g5dih	241	23	of	of	IN
cord-277355-si3g5dih	241	24	the	the	DT
cord-277355-si3g5dih	241	25	dengue	dengue	NN
cord-277355-si3g5dih	241	26	virus	virus	NN
cord-277355-si3g5dih	241	27	replication	replication	NN
cord-277355-si3g5dih	241	28	and	and	CC
cord-277355-si3g5dih	241	29	assembly	assembly	NN
cord-277355-si3g5dih	241	30	sites	site	NNS
cord-277355-si3g5dih	242	1	Immature	immature	JJ
cord-277355-si3g5dih	242	2	and	and	CC
cord-277355-si3g5dih	242	3	mature	mature	JJ
cord-277355-si3g5dih	242	4	dengue	dengue	NN
cord-277355-si3g5dih	242	5	serotype	serotype	NN
cord-277355-si3g5dih	242	6	1	1	CD
cord-277355-si3g5dih	242	7	virus	virus	NN
cord-277355-si3g5dih	242	8	structures	structure	NNS
cord-277355-si3g5dih	242	9	provide	provide	VBP
cord-277355-si3g5dih	242	10	insight	insight	NN
cord-277355-si3g5dih	242	11	into	into	IN
cord-277355-si3g5dih	242	12	the	the	DT
cord-277355-si3g5dih	242	13	maturation	maturation	NN
cord-277355-si3g5dih	242	14	process	process	NN
cord-277355-si3g5dih	242	15	Dengue	dengue	NN
cord-277355-si3g5dih	243	1	NS2A	NS2A	NNP
cord-277355-si3g5dih	243	2	protein	protein	NN
cord-277355-si3g5dih	243	3	orchestrates	orchestrate	VBZ
cord-277355-si3g5dih	243	4	virus	virus	NN
cord-277355-si3g5dih	243	5	assembly	assembly	NN
cord-277355-si3g5dih	244	1	e608	e608	NNP
cord-277355-si3g5dih	245	1	A	a	DT
cord-277355-si3g5dih	245	2	structural	structural	JJ
cord-277355-si3g5dih	245	3	perspective	perspective	NN
cord-277355-si3g5dih	245	4	of	of	IN
cord-277355-si3g5dih	245	5	the	the	DT
cord-277355-si3g5dih	245	6	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	245	7	life	life	NN
cord-277355-si3g5dih	245	8	cycle	cycle	NN
cord-277355-si3g5dih	245	9	Two	two	CD
cord-277355-si3g5dih	245	10	distinct	distinct	JJ
cord-277355-si3g5dih	245	11	size	size	NN
cord-277355-si3g5dih	245	12	classes	class	NNS
cord-277355-si3g5dih	245	13	of	of	IN
cord-277355-si3g5dih	245	14	immature	immature	JJ
cord-277355-si3g5dih	245	15	and	and	CC
cord-277355-si3g5dih	245	16	mature	mature	JJ
cord-277355-si3g5dih	245	17	subviral	subviral	JJ
cord-277355-si3g5dih	245	18	particles	particle	NNS
cord-277355-si3g5dih	245	19	from	from	IN
cord-277355-si3g5dih	245	20	tick	tick	VB
cord-277355-si3g5dih	245	21	-	-	HYPH
cord-277355-si3g5dih	245	22	borne	bear	VBN
cord-277355-si3g5dih	245	23	encephalitis	encephalitis	JJ
cord-277355-si3g5dih	245	24	virus	virus	NN
cord-277355-si3g5dih	245	25	Molecular	molecular	JJ
cord-277355-si3g5dih	245	26	organization	organization	NN
cord-277355-si3g5dih	245	27	of	of	IN
cord-277355-si3g5dih	245	28	a	a	DT
cord-277355-si3g5dih	245	29	recombinant	recombinant	JJ
cord-277355-si3g5dih	245	30	subviral	subviral	JJ
cord-277355-si3g5dih	245	31	particle	particle	NN
cord-277355-si3g5dih	245	32	from	from	IN
cord-277355-si3g5dih	245	33	tick	tick	NN
cord-277355-si3g5dih	245	34	-	-	HYPH
cord-277355-si3g5dih	245	35	borne	bear	VBN
cord-277355-si3g5dih	245	36	encephalitis	encephalitis	JJ
cord-277355-si3g5dih	245	37	virus	virus	NN
cord-277355-si3g5dih	245	38	Recombinant	recombinant	JJ
cord-277355-si3g5dih	245	39	and	and	CC
cord-277355-si3g5dih	245	40	virion	virion	NN
cord-277355-si3g5dih	245	41	-	-	HYPH
cord-277355-si3g5dih	245	42	derived	derive	VBN
cord-277355-si3g5dih	245	43	soluble	soluble	JJ
cord-277355-si3g5dih	245	44	and	and	CC
cord-277355-si3g5dih	245	45	particulate	particulate	JJ
cord-277355-si3g5dih	245	46	immunogens	immunogen	NNS
cord-277355-si3g5dih	245	47	for	for	IN
cord-277355-si3g5dih	245	48	vaccination	vaccination	NN
cord-277355-si3g5dih	245	49	against	against	IN
cord-277355-si3g5dih	245	50	tick	tick	NN
cord-277355-si3g5dih	245	51	-	-	HYPH
cord-277355-si3g5dih	245	52	borne	bear	VBN
cord-277355-si3g5dih	245	53	encephalitis	encephalitis	JJ
cord-277355-si3g5dih	245	54	Membrane	membrane	NN
cord-277355-si3g5dih	245	55	fusion	fusion	NN
cord-277355-si3g5dih	245	56	activity	activity	NN
cord-277355-si3g5dih	245	57	of	of	IN
cord-277355-si3g5dih	245	58	tick	tick	NN
cord-277355-si3g5dih	245	59	-	-	HYPH
cord-277355-si3g5dih	245	60	borne	bear	VBN
cord-277355-si3g5dih	245	61	encephalitis	encephalitis	JJ
cord-277355-si3g5dih	245	62	virus	virus	NN
cord-277355-si3g5dih	245	63	and	and	CC
cord-277355-si3g5dih	245	64	recombinant	recombinant	JJ
cord-277355-si3g5dih	245	65	subviral	subviral	JJ
cord-277355-si3g5dih	245	66	particles	particle	NNS
cord-277355-si3g5dih	245	67	in	in	IN
cord-277355-si3g5dih	245	68	a	a	DT
cord-277355-si3g5dih	245	69	liposomal	liposomal	JJ
cord-277355-si3g5dih	245	70	model	model	NN
cord-277355-si3g5dih	245	71	system	system	NN
cord-277355-si3g5dih	245	72	Dengue	Dengue	NNP
cord-277355-si3g5dih	245	73	virus	virus	NN
cord-277355-si3g5dih	245	74	genome	genome	NN
cord-277355-si3g5dih	245	75	uncoating	uncoating	NN
cord-277355-si3g5dih	245	76	requires	require	VBZ
cord-277355-si3g5dih	245	77	ubiquitination	ubiquitination	JJ
cord-277355-si3g5dih	245	78	Zika	Zika	NNP
cord-277355-si3g5dih	245	79	virus	virus	NN
cord-277355-si3g5dih	245	80	outbreak	outbreak	NN
cord-277355-si3g5dih	245	81	:	:	:
cord-277355-si3g5dih	245	82	'	'	''
cord-277355-si3g5dih	245	83	a	a	DT
cord-277355-si3g5dih	245	84	perfect	perfect	JJ
cord-277355-si3g5dih	245	85	storm	storm	NN
cord-277355-si3g5dih	246	1	A	a	DT
cord-277355-si3g5dih	246	2	review	review	NN
cord-277355-si3g5dih	246	3	of	of	IN
cord-277355-si3g5dih	246	4	successful	successful	JJ
cord-277355-si3g5dih	246	5	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	246	6	vaccines	vaccine	NNS
cord-277355-si3g5dih	246	7	and	and	CC
cord-277355-si3g5dih	246	8	the	the	DT
cord-277355-si3g5dih	246	9	problems	problem	NNS
cord-277355-si3g5dih	246	10	with	with	IN
cord-277355-si3g5dih	246	11	those	those	DT
cord-277355-si3g5dih	246	12	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	246	13	for	for	IN
cord-277355-si3g5dih	246	14	which	which	WDT
cord-277355-si3g5dih	246	15	vaccines	vaccine	NNS
cord-277355-si3g5dih	246	16	are	be	VBP
cord-277355-si3g5dih	246	17	not	not	RB
cord-277355-si3g5dih	246	18	yet	yet	RB
cord-277355-si3g5dih	246	19	available	available	JJ
cord-277355-si3g5dih	246	20	Viscerotropic	Viscerotropic	NNP
cord-277355-si3g5dih	246	21	and	and	CC
cord-277355-si3g5dih	246	22	neurotropic	neurotropic	NNP
cord-277355-si3g5dih	246	23	disease	disease	NN
cord-277355-si3g5dih	246	24	following	follow	VBG
cord-277355-si3g5dih	246	25	vaccination	vaccination	NN
cord-277355-si3g5dih	246	26	with	with	IN
cord-277355-si3g5dih	246	27	the	the	DT
cord-277355-si3g5dih	246	28	17D	17D	NNP
cord-277355-si3g5dih	246	29	yellow	yellow	JJ
cord-277355-si3g5dih	246	30	fever	fever	NN
cord-277355-si3g5dih	246	31	vaccine	vaccine	NN
cord-277355-si3g5dih	246	32	,	,	,
cord-277355-si3g5dih	246	33	ARILVAX	ARILVAX	NNP
cord-277355-si3g5dih	246	34	Ò	Ò	NNP
cord-277355-si3g5dih	246	35	New	New	NNP
cord-277355-si3g5dih	246	36	developments	development	NNS
cord-277355-si3g5dih	246	37	in	in	IN
cord-277355-si3g5dih	246	38	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	246	39	vaccines	vaccine	NNS
cord-277355-si3g5dih	246	40	with	with	IN
cord-277355-si3g5dih	246	41	special	special	JJ
cord-277355-si3g5dih	246	42	attention	attention	NN
cord-277355-si3g5dih	246	43	to	to	IN
cord-277355-si3g5dih	246	44	yellow	yellow	JJ
cord-277355-si3g5dih	246	45	fever	fever	NN
cord-277355-si3g5dih	247	1	Recent	recent	JJ
cord-277355-si3g5dih	247	2	advances	advance	NNS
cord-277355-si3g5dih	247	3	in	in	IN
cord-277355-si3g5dih	247	4	human	human	JJ
cord-277355-si3g5dih	247	5	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	247	6	vaccines	vaccine	NNS
cord-277355-si3g5dih	247	7	Attenuated	attenuate	VBN
cord-277355-si3g5dih	247	8	dengue	dengue	NN
cord-277355-si3g5dih	247	9	2	2	CD
cord-277355-si3g5dih	247	10	viruses	virus	NNS
cord-277355-si3g5dih	247	11	with	with	IN
cord-277355-si3g5dih	247	12	deletions	deletion	NNS
cord-277355-si3g5dih	247	13	in	in	IN
cord-277355-si3g5dih	247	14	capsid	capsid	NN
cord-277355-si3g5dih	247	15	protein	protein	NN
cord-277355-si3g5dih	247	16	derived	derive	VBN
cord-277355-si3g5dih	247	17	from	from	IN
cord-277355-si3g5dih	247	18	an	an	DT
cord-277355-si3g5dih	247	19	infectious	infectious	JJ
cord-277355-si3g5dih	247	20	full	full	JJ
cord-277355-si3g5dih	247	21	-	-	HYPH
cord-277355-si3g5dih	247	22	length	length	NN
cord-277355-si3g5dih	247	23	cDNA	cdna	NN
cord-277355-si3g5dih	247	24	clone	clone	NN
cord-277355-si3g5dih	247	25	Characterization	characterization	NN
cord-277355-si3g5dih	247	26	of	of	IN
cord-277355-si3g5dih	247	27	West	West	NNP
cord-277355-si3g5dih	247	28	Nile	Nile	NNP
cord-277355-si3g5dih	247	29	virus	virus	NN
cord-277355-si3g5dih	247	30	live	live	VBP
cord-277355-si3g5dih	247	31	vaccine	vaccine	NN
cord-277355-si3g5dih	247	32	candidates	candidate	NNS
cord-277355-si3g5dih	247	33	attenuated	attenuate	VBN
cord-277355-si3g5dih	247	34	by	by	IN
cord-277355-si3g5dih	247	35	capsid	capsid	NN
cord-277355-si3g5dih	247	36	deletion	deletion	NN
cord-277355-si3g5dih	247	37	mutations	mutation	NNS
cord-277355-si3g5dih	248	1	The	the	DT
cord-277355-si3g5dih	248	2	yellow	yellow	JJ
cord-277355-si3g5dih	248	3	fever	fever	NN
cord-277355-si3g5dih	248	4	17D	17d	CD
cord-277355-si3g5dih	248	5	vaccine	vaccine	NN
cord-277355-si3g5dih	248	6	virus	virus	NN
cord-277355-si3g5dih	248	7	as	as	IN
cord-277355-si3g5dih	248	8	a	a	DT
cord-277355-si3g5dih	248	9	vector	vector	NN
cord-277355-si3g5dih	248	10	for	for	IN
cord-277355-si3g5dih	248	11	the	the	DT
cord-277355-si3g5dih	248	12	expression	expression	NN
cord-277355-si3g5dih	248	13	of	of	IN
cord-277355-si3g5dih	248	14	foreign	foreign	JJ
cord-277355-si3g5dih	248	15	proteins	protein	NNS
cord-277355-si3g5dih	248	16	:	:	:
cord-277355-si3g5dih	248	17	development	development	NN
cord-277355-si3g5dih	248	18	of	of	IN
cord-277355-si3g5dih	248	19	new	new	JJ
cord-277355-si3g5dih	248	20	live	live	NNP
cord-277355-si3g5dih	248	21	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	249	1	vaccines	vaccine	NNS
cord-277355-si3g5dih	249	2	A	a	DT
cord-277355-si3g5dih	249	3	trans	trans	NN
cord-277355-si3g5dih	249	4	-	-	JJ
cord-277355-si3g5dih	249	5	Complementing	complement	VBG
cord-277355-si3g5dih	249	6	recombination	recombination	NN
cord-277355-si3g5dih	249	7	trap	trap	NN
cord-277355-si3g5dih	249	8	demonstrates	demonstrate	VBZ
cord-277355-si3g5dih	249	9	a	a	DT
cord-277355-si3g5dih	249	10	low	low	JJ
cord-277355-si3g5dih	249	11	propensity	propensity	NN
cord-277355-si3g5dih	249	12	of	of	IN
cord-277355-si3g5dih	249	13	flaviviruses	flavivirus	NNS
cord-277355-si3g5dih	249	14	for	for	IN
cord-277355-si3g5dih	249	15	intermolecular	intermolecular	JJ
cord-277355-si3g5dih	249	16	recombination	recombination	NN
cord-277355-si3g5dih	249	17	Nucleic	nucleic	CD
cord-277355-si3g5dih	249	18	acid	acid	NN
cord-277355-si3g5dih	249	19	-	-	HYPH
cord-277355-si3g5dih	249	20	based	base	VBN
cord-277355-si3g5dih	249	21	infectious	infectious	JJ
cord-277355-si3g5dih	249	22	and	and	CC
cord-277355-si3g5dih	249	23	pseudoinfectious	pseudoinfectious	JJ
cord-277355-si3g5dih	249	24	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	249	25	vaccines	vaccine	NNS
cord-277355-si3g5dih	249	26	Humoral	Humoral	NNP
cord-277355-si3g5dih	249	27	and	and	CC
cord-277355-si3g5dih	249	28	cellular	cellular	JJ
cord-277355-si3g5dih	249	29	immune	immune	JJ
cord-277355-si3g5dih	249	30	response	response	NN
cord-277355-si3g5dih	249	31	to	to	IN
cord-277355-si3g5dih	249	32	RNA	RNA	NNP
cord-277355-si3g5dih	249	33	immunization	immunization	NN
cord-277355-si3g5dih	249	34	with	with	IN
cord-277355-si3g5dih	249	35	flavivirus	flavivirus	NNP
cord-277355-si3g5dih	249	36	replicons	replicon	NNS
cord-277355-si3g5dih	249	37	derived	derive	VBN
cord-277355-si3g5dih	249	38	from	from	IN
cord-277355-si3g5dih	249	39	tickborne	tickborne	NNP
cord-277355-si3g5dih	249	40	encephalitis	encephalitis	NN
cord-277355-si3g5dih	249	41	virus	virus	NN
cord-277355-si3g5dih	249	42	Immunogenicity	Immunogenicity	NNP
cord-277355-si3g5dih	249	43	of	of	IN
cord-277355-si3g5dih	249	44	West	West	NNP
cord-277355-si3g5dih	249	45	Nile	Nile	NNP
cord-277355-si3g5dih	249	46	virus	virus	NN
cord-277355-si3g5dih	249	47	infectious	infectious	JJ
cord-277355-si3g5dih	249	48	DNA	dna	NN
cord-277355-si3g5dih	249	49	and	and	CC
cord-277355-si3g5dih	249	50	its	-PRON-	PRP$
cord-277355-si3g5dih	249	51	noninfectious	noninfectious	JJ
cord-277355-si3g5dih	249	52	derivatives	derivative	NNS
cord-277355-si3g5dih	249	53	trans	trans	NNP
cord-277355-si3g5dih	249	54	-	-	HYPH
cord-277355-si3g5dih	249	55	Packaged	package	VBN
cord-277355-si3g5dih	249	56	West	West	NNP
cord-277355-si3g5dih	249	57	Nile	Nile	NNP
cord-277355-si3g5dih	249	58	virus	virus	NN
cord-277355-si3g5dih	249	59	-	-	HYPH
cord-277355-si3g5dih	249	60	like	like	JJ
cord-277355-si3g5dih	249	61	particles	particle	NNS
cord-277355-si3g5dih	249	62	:	:	:
cord-277355-si3g5dih	249	63	infectious	infectious	JJ
cord-277355-si3g5dih	249	64	properties	property	NNS
cord-277355-si3g5dih	249	65	in	in	IN
cord-277355-si3g5dih	249	66	vitro	vitro	FW
cord-277355-si3g5dih	249	67	and	and	CC
cord-277355-si3g5dih	249	68	in	in	IN
cord-277355-si3g5dih	249	69	infected	infected	JJ
cord-277355-si3g5dih	249	70	mosquito	mosquito	NN
cord-277355-si3g5dih	249	71	vectors	vector	NNS
cord-277355-si3g5dih	249	72	Packaging	package	VBG
cord-277355-si3g5dih	249	73	the	the	DT
cord-277355-si3g5dih	249	74	replicon	replicon	NNP
cord-277355-si3g5dih	249	75	RNA	RNA	NNP
cord-277355-si3g5dih	249	76	of	of	IN
cord-277355-si3g5dih	249	77	the	the	DT
cord-277355-si3g5dih	249	78	Far	far	JJ
cord-277355-si3g5dih	249	79	-	-	HYPH
cord-277355-si3g5dih	249	80	Eastern	eastern	JJ
cord-277355-si3g5dih	249	81	subtype	subtype	NN
cord-277355-si3g5dih	249	82	of	of	IN
cord-277355-si3g5dih	249	83	tick	tick	NN
cord-277355-si3g5dih	249	84	-	-	HYPH
cord-277355-si3g5dih	249	85	borne	bear	VBN
cord-277355-si3g5dih	249	86	encephalitis	encephalitis	JJ
cord-277355-si3g5dih	249	87	virus	virus	NN
cord-277355-si3g5dih	249	88	into	into	IN
cord-277355-si3g5dih	249	89	single	single	JJ
cord-277355-si3g5dih	249	90	-	-	HYPH
cord-277355-si3g5dih	249	91	round	round	NN
cord-277355-si3g5dih	249	92	infectious	infectious	JJ
cord-277355-si3g5dih	249	93	particles	particle	NNS
cord-277355-si3g5dih	249	94	:	:	:
cord-277355-si3g5dih	249	95	development	development	NN
cord-277355-si3g5dih	249	96	of	of	IN
cord-277355-si3g5dih	249	97	a	a	DT
cord-277355-si3g5dih	249	98	heterologous	heterologous	JJ
cord-277355-si3g5dih	249	99	gene	gene	NN
cord-277355-si3g5dih	249	100	delivery	delivery	NN
cord-277355-si3g5dih	249	101	system	system	NN
cord-277355-si3g5dih	250	1	A	a	DT
cord-277355-si3g5dih	250	2	rapid	rapid	JJ
cord-277355-si3g5dih	250	3	and	and	CC
cord-277355-si3g5dih	250	4	quantitative	quantitative	JJ
cord-277355-si3g5dih	250	5	assay	assay	NN
cord-277355-si3g5dih	250	6	for	for	IN
cord-277355-si3g5dih	250	7	measuring	measure	VBG
cord-277355-si3g5dih	250	8	antibody	antibody	NN
cord-277355-si3g5dih	250	9	-	-	HYPH
cord-277355-si3g5dih	250	10	mediated	mediate	VBN
cord-277355-si3g5dih	250	11	neutralization	neutralization	NN
cord-277355-si3g5dih	250	12	of	of	IN
cord-277355-si3g5dih	250	13	West	West	NNP
cord-277355-si3g5dih	250	14	Nile	Nile	NNP
cord-277355-si3g5dih	250	15	virus	virus	NN
cord-277355-si3g5dih	250	16	infection	infection	NN
cord-277355-si3g5dih	250	17	Construction	construction	NN
cord-277355-si3g5dih	250	18	and	and	CC
cord-277355-si3g5dih	250	19	characterization	characterization	NN
cord-277355-si3g5dih	250	20	of	of	IN
cord-277355-si3g5dih	250	21	a	a	DT
cord-277355-si3g5dih	250	22	second	second	JJ
cord-277355-si3g5dih	250	23	-	-	HYPH
cord-277355-si3g5dih	250	24	generation	generation	NN
cord-277355-si3g5dih	250	25	pseudoinfectious	pseudoinfectious	JJ
cord-277355-si3g5dih	250	26	West	West	NNP
cord-277355-si3g5dih	250	27	Nile	Nile	NNP
cord-277355-si3g5dih	250	28	virus	virus	NN
cord-277355-si3g5dih	250	29	vaccine	vaccine	NN
cord-277355-si3g5dih	250	30	propagated	propagate	VBD
cord-277355-si3g5dih	250	31	using	use	VBG
cord-277355-si3g5dih	250	32	a	a	DT
cord-277355-si3g5dih	250	33	new	new	JJ
cord-277355-si3g5dih	250	34	cultivation	cultivation	NN
cord-277355-si3g5dih	250	35	system	system	NN
cord-277355-si3g5dih	250	36	Production	production	NN
cord-277355-si3g5dih	250	37	of	of	IN
cord-277355-si3g5dih	250	38	pseudoinfectious	pseudoinfectious	JJ
cord-277355-si3g5dih	250	39	yellow	yellow	JJ
cord-277355-si3g5dih	250	40	fever	fever	NN
cord-277355-si3g5dih	250	41	virus	virus	NN
cord-277355-si3g5dih	250	42	with	with	IN
cord-277355-si3g5dih	250	43	a	a	DT
cord-277355-si3g5dih	250	44	two	two	CD
cord-277355-si3g5dih	250	45	-	-	HYPH
cord-277355-si3g5dih	250	46	component	component	NN
cord-277355-si3g5dih	250	47	genome	genome	NN
cord-277355-si3g5dih	250	48	Highly	highly	RB
cord-277355-si3g5dih	250	49	efficient	efficient	JJ
cord-277355-si3g5dih	250	50	production	production	NN
cord-277355-si3g5dih	250	51	of	of	IN
cord-277355-si3g5dih	250	52	a	a	DT
cord-277355-si3g5dih	250	53	dengue	dengue	NN
cord-277355-si3g5dih	250	54	pseudoinfectious	pseudoinfectious	JJ
cord-277355-si3g5dih	250	55	virus	virus	NN
cord-277355-si3g5dih	250	56	Enhanced	enhanced	JJ
cord-277355-si3g5dih	250	57	production	production	NN
cord-277355-si3g5dih	250	58	of	of	IN
cord-277355-si3g5dih	250	59	infectious	infectious	JJ
cord-277355-si3g5dih	250	60	particles	particle	NNS
cord-277355-si3g5dih	250	61	by	by	IN
cord-277355-si3g5dih	250	62	adaptive	adaptive	JJ
cord-277355-si3g5dih	250	63	modulation	modulation	NN
cord-277355-si3g5dih	250	64	of	of	IN
cord-277355-si3g5dih	250	65	C	c	NN
cord-277355-si3g5dih	250	66	-	-	HYPH
cord-277355-si3g5dih	250	67	prM	prm	JJ
cord-277355-si3g5dih	250	68	processing	processing	NN
cord-277355-si3g5dih	250	69	and	and	CC
cord-277355-si3g5dih	250	70	C	C	NNP
cord-277355-si3g5dih	250	71	-	-	HYPH
cord-277355-si3g5dih	250	72	C	c	NN
cord-277355-si3g5dih	250	73	interaction	interaction	NN
cord-277355-si3g5dih	250	74	during	during	IN
cord-277355-si3g5dih	250	75	propagation	propagation	NN
cord-277355-si3g5dih	250	76	of	of	IN
cord-277355-si3g5dih	250	77	dengue	dengue	NN
cord-277355-si3g5dih	250	78	pseudoinfectious	pseudoinfectious	JJ
cord-277355-si3g5dih	250	79	virus	virus	NN
cord-277355-si3g5dih	250	80	in	in	IN
cord-277355-si3g5dih	250	81	stable	stable	JJ
cord-277355-si3g5dih	250	82	CprME	cprme	NN
cord-277355-si3g5dih	250	83	-	-	HYPH
cord-277355-si3g5dih	250	84	expressing	express	VBG
cord-277355-si3g5dih	250	85	cells	cell	NNS
cord-277355-si3g5dih	250	86	RepliVAX	RepliVAX	.
cord-277355-si3g5dih	251	1	WN	WN	NNP
cord-277355-si3g5dih	251	2	,	,	,
cord-277355-si3g5dih	251	3	a	a	DT
cord-277355-si3g5dih	251	4	single	single	JJ
cord-277355-si3g5dih	251	5	-	-	HYPH
cord-277355-si3g5dih	251	6	cycle	cycle	NN
cord-277355-si3g5dih	251	7	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	251	8	vaccine	vaccine	NN
cord-277355-si3g5dih	251	9	to	to	TO
cord-277355-si3g5dih	251	10	prevent	prevent	VB
cord-277355-si3g5dih	251	11	West	West	NNP
cord-277355-si3g5dih	251	12	Nile	Nile	NNP
cord-277355-si3g5dih	251	13	disease	disease	NN
cord-277355-si3g5dih	251	14	,	,	,
cord-277355-si3g5dih	251	15	elicits	elicit	VBZ
cord-277355-si3g5dih	251	16	durable	durable	JJ
cord-277355-si3g5dih	251	17	protective	protective	JJ
cord-277355-si3g5dih	251	18	immunity	immunity	NN
cord-277355-si3g5dih	251	19	in	in	IN
cord-277355-si3g5dih	251	20	hamsters	hamster	NNS
cord-277355-si3g5dih	251	21	Characterization	characterization	NN
cord-277355-si3g5dih	251	22	of	of	IN
cord-277355-si3g5dih	251	23	the	the	DT
cord-277355-si3g5dih	251	24	RepliVax	RepliVax	NNP
cord-277355-si3g5dih	251	25	platform	platform	NN
cord-277355-si3g5dih	251	26	for	for	IN
cord-277355-si3g5dih	251	27	replication	replication	NN
cord-277355-si3g5dih	251	28	-	-	HYPH
cord-277355-si3g5dih	251	29	defective	defective	JJ
cord-277355-si3g5dih	251	30	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	251	31	vaccines	vaccine	NNS
cord-277355-si3g5dih	251	32	Repeated	repeat	VBN
cord-277355-si3g5dih	251	33	in	in	IN
cord-277355-si3g5dih	251	34	vivo	vivo	NN
cord-277355-si3g5dih	251	35	stimulation	stimulation	NN
cord-277355-si3g5dih	251	36	of	of	IN
cord-277355-si3g5dih	251	37	T	T	NNP
cord-277355-si3g5dih	251	38	and	and	CC
cord-277355-si3g5dih	251	39	B	b	NN
cord-277355-si3g5dih	251	40	cell	cell	NN
cord-277355-si3g5dih	251	41	responses	response	NNS
cord-277355-si3g5dih	251	42	in	in	IN
cord-277355-si3g5dih	251	43	old	old	JJ
cord-277355-si3g5dih	251	44	mice	mouse	NNS
cord-277355-si3g5dih	252	1	generates	generate	VBZ
cord-277355-si3g5dih	252	2	protective	protective	JJ
cord-277355-si3g5dih	252	3	immunity	immunity	NN
cord-277355-si3g5dih	252	4	against	against	IN
cord-277355-si3g5dih	252	5	lethal	lethal	JJ
cord-277355-si3g5dih	252	6	West	West	NNP
cord-277355-si3g5dih	252	7	Nile	Nile	NNP
cord-277355-si3g5dih	252	8	virus	virus	NN
cord-277355-si3g5dih	252	9	encephalitis	encephalitis	RB
cord-277355-si3g5dih	252	10	Immunogenicity	immunogenicity	NN
cord-277355-si3g5dih	252	11	of	of	IN
cord-277355-si3g5dih	252	12	RepliVAX	RepliVAX	NNP
cord-277355-si3g5dih	252	13	WN	WN	NNP
cord-277355-si3g5dih	252	14	,	,	,
cord-277355-si3g5dih	252	15	a	a	DT
cord-277355-si3g5dih	252	16	novel	novel	JJ
cord-277355-si3g5dih	252	17	single	single	JJ
cord-277355-si3g5dih	252	18	-	-	HYPH
cord-277355-si3g5dih	252	19	cycle	cycle	NN
cord-277355-si3g5dih	252	20	West	West	NNP
cord-277355-si3g5dih	252	21	Nile	Nile	NNP
cord-277355-si3g5dih	252	22	virus	virus	NN
cord-277355-si3g5dih	252	23	vaccine	vaccine	NN
cord-277355-si3g5dih	252	24	Construction	construction	NN
cord-277355-si3g5dih	252	25	and	and	CC
cord-277355-si3g5dih	252	26	evaluation	evaluation	NN
cord-277355-si3g5dih	252	27	of	of	IN
cord-277355-si3g5dih	252	28	a	a	DT
cord-277355-si3g5dih	252	29	chimeric	chimeric	JJ
cord-277355-si3g5dih	252	30	pseudoinfectious	pseudoinfectious	JJ
cord-277355-si3g5dih	252	31	virus	virus	NN
cord-277355-si3g5dih	252	32	vaccine	vaccine	NN
cord-277355-si3g5dih	252	33	to	to	TO
cord-277355-si3g5dih	252	34	prevent	prevent	VB
cord-277355-si3g5dih	252	35	Japanese	japanese	JJ
cord-277355-si3g5dih	252	36	encephalitis	encephalitis	NN
cord-277355-si3g5dih	252	37	Construction	construction	NN
cord-277355-si3g5dih	252	38	and	and	CC
cord-277355-si3g5dih	252	39	characterization	characterization	NN
cord-277355-si3g5dih	252	40	of	of	IN
cord-277355-si3g5dih	252	41	a	a	DT
cord-277355-si3g5dih	252	42	single	single	JJ
cord-277355-si3g5dih	252	43	-	-	HYPH
cord-277355-si3g5dih	252	44	cycle	cycle	NN
cord-277355-si3g5dih	252	45	chimeric	chimeric	JJ
cord-277355-si3g5dih	252	46	flavivirus	flavivirus	JJ
cord-277355-si3g5dih	252	47	vaccine	vaccine	NN
cord-277355-si3g5dih	252	48	candidate	candidate	NN
cord-277355-si3g5dih	252	49	that	that	WDT
cord-277355-si3g5dih	252	50	protects	protect	VBZ
cord-277355-si3g5dih	252	51	mice	mouse	NNS
cord-277355-si3g5dih	252	52	against	against	IN
cord-277355-si3g5dih	252	53	lethal	lethal	JJ
cord-277355-si3g5dih	252	54	challenge	challenge	NN
cord-277355-si3g5dih	252	55	with	with	IN
cord-277355-si3g5dih	252	56	dengue	dengue	NN
cord-277355-si3g5dih	252	57	virus	virus	NN
cord-277355-si3g5dih	252	58	type	type	NN
cord-277355-si3g5dih	252	59	2	2	CD
cord-277355-si3g5dih	252	60	Efficient	efficient	JJ
cord-277355-si3g5dih	252	61	,	,	,
cord-277355-si3g5dih	252	62	trans	trans	JJ
cord-277355-si3g5dih	252	63	-	-	JJ
cord-277355-si3g5dih	252	64	complementing	complement	VBG
cord-277355-si3g5dih	252	65	packaging	packaging	NN
cord-277355-si3g5dih	252	66	systems	system	NNS
cord-277355-si3g5dih	252	67	for	for	IN
cord-277355-si3g5dih	252	68	chimeric	chimeric	JJ
cord-277355-si3g5dih	252	69	,	,	,
cord-277355-si3g5dih	252	70	pseudoinfectious	pseudoinfectious	JJ
cord-277355-si3g5dih	252	71	dengue	dengue	NN
cord-277355-si3g5dih	252	72	2	2	CD
cord-277355-si3g5dih	253	1	/yellow	/yellow	,
cord-277355-si3g5dih	253	2	fever	fever	NN
cord-277355-si3g5dih	253	3	viruses	viruse	VBZ
cord-277355-si3g5dih	253	4	Single	single	JJ
cord-277355-si3g5dih	253	5	-	-	HYPH
cord-277355-si3g5dih	253	6	dose	dose	NN
cord-277355-si3g5dih	253	7	vaccine	vaccine	NN
cord-277355-si3g5dih	253	8	against	against	IN
cord-277355-si3g5dih	253	9	tick	tick	VB
cord-277355-si3g5dih	253	10	-	-	HYPH
cord-277355-si3g5dih	253	11	borne	bear	VBN
cord-277355-si3g5dih	253	12	encephalitis	encephalitis	JJ
cord-277355-si3g5dih	253	13	Single	single	JJ
cord-277355-si3g5dih	253	14	-	-	HYPH
cord-277355-si3g5dih	253	15	round	round	NN
cord-277355-si3g5dih	253	16	infectious	infectious	JJ
cord-277355-si3g5dih	253	17	particles	particle	NNS
cord-277355-si3g5dih	253	18	enhance	enhance	VBP
cord-277355-si3g5dih	253	19	immunogenicity	immunogenicity	NN
cord-277355-si3g5dih	253	20	of	of	IN
cord-277355-si3g5dih	253	21	a	a	DT
cord-277355-si3g5dih	253	22	DNA	dna	NN
cord-277355-si3g5dih	253	23	vaccine	vaccine	NN
cord-277355-si3g5dih	253	24	against	against	IN
cord-277355-si3g5dih	253	25	West	West	NNP
cord-277355-si3g5dih	253	26	Nile	Nile	NNP
cord-277355-si3g5dih	253	27	virus	virus	NN
cord-277355-si3g5dih	254	1	Selfamplifying	Selfamplifying	NNP
cord-277355-si3g5dih	254	2	mRNA	mRNA	NNP
cord-277355-si3g5dih	255	1	vaccines	vaccine	NNS
cord-277355-si3g5dih	255	2	mRNA	mRNA	NNP
cord-277355-si3g5dih	256	1	vaccines	vaccine	NNS
cord-277355-si3g5dih	256	2	-	-	:
cord-277355-si3g5dih	256	3	a	a	DT
cord-277355-si3g5dih	256	4	new	new	JJ
cord-277355-si3g5dih	256	5	era	era	NN
cord-277355-si3g5dih	256	6	in	in	IN
cord-277355-si3g5dih	256	7	vaccinology	vaccinology	NN
cord-277355-si3g5dih	257	1	The	the	DT
cord-277355-si3g5dih	257	2	authors	author	NNS
cord-277355-si3g5dih	257	3	declare	declare	VBP
cord-277355-si3g5dih	257	4	that	that	IN
cord-277355-si3g5dih	257	5	they	-PRON-	PRP
cord-277355-si3g5dih	257	6	have	have	VBP
cord-277355-si3g5dih	257	7	no	no	DT
cord-277355-si3g5dih	257	8	known	know	VBN
cord-277355-si3g5dih	257	9	competing	compete	VBG
cord-277355-si3g5dih	257	10	financial	financial	JJ
cord-277355-si3g5dih	257	11	interests	interest	NNS
cord-277355-si3g5dih	257	12	or	or	CC
cord-277355-si3g5dih	257	13	personal	personal	JJ
cord-277355-si3g5dih	257	14	relationships	relationship	NNS
cord-277355-si3g5dih	257	15	that	that	WDT
cord-277355-si3g5dih	257	16	could	could	MD
cord-277355-si3g5dih	257	17	have	have	VB
cord-277355-si3g5dih	257	18	appeared	appear	VBN
cord-277355-si3g5dih	257	19	to	to	TO
cord-277355-si3g5dih	257	20	influence	influence	VB
cord-277355-si3g5dih	257	21	the	the	DT
cord-277355-si3g5dih	257	22	work	work	NN
cord-277355-si3g5dih	257	23	reported	report	VBN
cord-277355-si3g5dih	257	24	in	in	IN
cord-277355-si3g5dih	257	25	this	this	DT
cord-277355-si3g5dih	257	26	paper	paper	NN
cord-277355-si3g5dih	257	27	.	.	.