id	sid	tid	token	lemma	pos
cord-290802-761wqgbe	1	1	key	key	NN
cord-290802-761wqgbe	1	2	:	:	:
cord-290802-761wqgbe	2	1	cord-290802	cord-290802	NNP
cord-290802-761wqgbe	2	2	-	-	HYPH
cord-290802-761wqgbe	2	3	761wqgbe	761wqgbe	CD
cord-290802-761wqgbe	2	4	authors	author	NNS
cord-290802-761wqgbe	2	5	:	:	:
cord-290802-761wqgbe	2	6	Zhao	Zhao	NNP
cord-290802-761wqgbe	2	7	,	,	,
cord-290802-761wqgbe	2	8	Zheng	Zheng	NNP
cord-290802-761wqgbe	2	9	;	;	:
cord-290802-761wqgbe	2	10	Bourne	Bourne	NNP
cord-290802-761wqgbe	2	11	,	,	,
cord-290802-761wqgbe	2	12	Philip	Philip	NNP
cord-290802-761wqgbe	2	13	E.	E.	NNP
cord-290802-761wqgbe	2	14	title	title	NN
cord-290802-761wqgbe	2	15	:	:	:
cord-290802-761wqgbe	2	16	Structural	Structural	NNP
cord-290802-761wqgbe	2	17	Insights	insight	NNS
cord-290802-761wqgbe	2	18	into	into	IN
cord-290802-761wqgbe	2	19	the	the	DT
cord-290802-761wqgbe	2	20	Binding	Binding	NNP
cord-290802-761wqgbe	2	21	Modes	Modes	NNPS
cord-290802-761wqgbe	2	22	of	of	IN
cord-290802-761wqgbe	2	23	Viral	Viral	NNP
cord-290802-761wqgbe	2	24	RNA	RNA	NNP
cord-290802-761wqgbe	2	25	-	-	HYPH
cord-290802-761wqgbe	2	26	Dependent	Dependent	NNP
cord-290802-761wqgbe	2	27	RNA	RNA	NNP
cord-290802-761wqgbe	2	28	Polymerases	Polymerases	NNP
cord-290802-761wqgbe	2	29	Using	use	VBG
cord-290802-761wqgbe	2	30	a	a	DT
cord-290802-761wqgbe	2	31	Function	function	NN
cord-290802-761wqgbe	2	32	-	-	HYPH
cord-290802-761wqgbe	2	33	Site	Site	NNP
cord-290802-761wqgbe	2	34	Interaction	Interaction	NNP
cord-290802-761wqgbe	2	35	Fingerprint	Fingerprint	NNP
cord-290802-761wqgbe	2	36	Method	Method	NNP
cord-290802-761wqgbe	2	37	for	for	IN
cord-290802-761wqgbe	2	38	RNA	RNA	NNP
cord-290802-761wqgbe	2	39	Virus	Virus	NNP
cord-290802-761wqgbe	2	40	Drug	Drug	NNP
cord-290802-761wqgbe	2	41	Discovery	Discovery	NNP
cord-290802-761wqgbe	2	42	date	date	NN
cord-290802-761wqgbe	2	43	:	:	:
cord-290802-761wqgbe	2	44	2020	2020	CD
cord-290802-761wqgbe	2	45	-	-	HYPH
cord-290802-761wqgbe	2	46	09	09	CD
cord-290802-761wqgbe	2	47	-	-	SYM
cord-290802-761wqgbe	2	48	18	18	CD
cord-290802-761wqgbe	2	49	journal	journal	NN
cord-290802-761wqgbe	2	50	:	:	:
cord-290802-761wqgbe	2	51	J	J	NNP
cord-290802-761wqgbe	2	52	Proteome	Proteome	NNP
cord-290802-761wqgbe	2	53	Res	res	NN
cord-290802-761wqgbe	2	54	DOI	doi	NN
cord-290802-761wqgbe	2	55	:	:	:
cord-290802-761wqgbe	3	1	10.1021	10.1021	CD
cord-290802-761wqgbe	3	2	/	/	SYM
cord-290802-761wqgbe	3	3	acs.jproteome.0c00623	acs.jproteome.0c00623	NNS
cord-290802-761wqgbe	3	4	sha	sha	NNP
cord-290802-761wqgbe	3	5	:	:	:
cord-290802-761wqgbe	3	6	c3f2ca673525fdd702e15188d225f6979527e89a	c3f2ca673525fdd702e15188d225f6979527e89a	NNS
cord-290802-761wqgbe	3	7	doc_id	doc_id	CD
cord-290802-761wqgbe	3	8	:	:	:
cord-290802-761wqgbe	3	9	290802	290802	CD
cord-290802-761wqgbe	3	10	cord_uid	cord_uid	NNS
cord-290802-761wqgbe	3	11	:	:	:
cord-290802-761wqgbe	4	1	761wqgbe	761wqgbe	CD
cord-290802-761wqgbe	5	1	[	[	-LRB-
cord-290802-761wqgbe	5	2	Image	image	NN
cord-290802-761wqgbe	5	3	:	:	:
cord-290802-761wqgbe	5	4	see	see	VB
cord-290802-761wqgbe	5	5	text	text	NN
cord-290802-761wqgbe	5	6	]	]	-RRB-
cord-290802-761wqgbe	6	1	The	the	DT
cord-290802-761wqgbe	6	2	coronavirus	coronavirus	NN
cord-290802-761wqgbe	6	3	disease	disease	NN
cord-290802-761wqgbe	6	4	of	of	IN
cord-290802-761wqgbe	6	5	2019	2019	CD
cord-290802-761wqgbe	6	6	(	(	-LRB-
cord-290802-761wqgbe	6	7	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	6	8	)	)	-RRB-
cord-290802-761wqgbe	6	9	pandemic	pandemic	NN
cord-290802-761wqgbe	6	10	speaks	speak	VBZ
cord-290802-761wqgbe	6	11	to	to	IN
cord-290802-761wqgbe	6	12	the	the	DT
cord-290802-761wqgbe	6	13	need	need	NN
cord-290802-761wqgbe	6	14	for	for	IN
cord-290802-761wqgbe	6	15	drugs	drug	NNS
cord-290802-761wqgbe	6	16	that	that	WDT
cord-290802-761wqgbe	6	17	not	not	RB
cord-290802-761wqgbe	6	18	only	only	RB
cord-290802-761wqgbe	6	19	are	be	VBP
cord-290802-761wqgbe	6	20	effective	effective	JJ
cord-290802-761wqgbe	6	21	but	but	CC
cord-290802-761wqgbe	6	22	also	also	RB
cord-290802-761wqgbe	6	23	remain	remain	VBP
cord-290802-761wqgbe	6	24	effective	effective	JJ
cord-290802-761wqgbe	6	25	given	give	VBN
cord-290802-761wqgbe	6	26	the	the	DT
cord-290802-761wqgbe	6	27	mutation	mutation	NN
cord-290802-761wqgbe	6	28	rate	rate	NN
cord-290802-761wqgbe	6	29	of	of	IN
cord-290802-761wqgbe	6	30	severe	severe	JJ
cord-290802-761wqgbe	6	31	acute	acute	JJ
cord-290802-761wqgbe	6	32	respiratory	respiratory	JJ
cord-290802-761wqgbe	6	33	syndrome	syndrome	NN
cord-290802-761wqgbe	6	34	coronavirus	coronavirus	NN
cord-290802-761wqgbe	6	35	2	2	CD
cord-290802-761wqgbe	7	1	(	(	-LRB-
cord-290802-761wqgbe	7	2	SARS	SARS	NNP
cord-290802-761wqgbe	7	3	-	-	HYPH
cord-290802-761wqgbe	7	4	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	7	5	)	)	-RRB-
cord-290802-761wqgbe	7	6	.	.	.
cord-290802-761wqgbe	8	1	To	to	IN
cord-290802-761wqgbe	8	2	this	this	DT
cord-290802-761wqgbe	8	3	end	end	NN
cord-290802-761wqgbe	8	4	,	,	,
cord-290802-761wqgbe	8	5	we	-PRON-	PRP
cord-290802-761wqgbe	8	6	describe	describe	VBP
cord-290802-761wqgbe	8	7	structural	structural	JJ
cord-290802-761wqgbe	8	8	binding	binding	NN
cord-290802-761wqgbe	8	9	-	-	HYPH
cord-290802-761wqgbe	8	10	site	site	NN
cord-290802-761wqgbe	8	11	insights	insight	NNS
cord-290802-761wqgbe	8	12	for	for	IN
cord-290802-761wqgbe	8	13	facilitating	facilitate	VBG
cord-290802-761wqgbe	8	14	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	8	15	drug	drug	NN
cord-290802-761wqgbe	8	16	design	design	NN
cord-290802-761wqgbe	8	17	when	when	WRB
cord-290802-761wqgbe	8	18	targeting	target	VBG
cord-290802-761wqgbe	8	19	RNA	rna	NN
cord-290802-761wqgbe	8	20	-	-	HYPH
cord-290802-761wqgbe	8	21	dependent	dependent	JJ
cord-290802-761wqgbe	8	22	RNA	RNA	NNP
cord-290802-761wqgbe	8	23	polymerase	polymerase	NN
cord-290802-761wqgbe	8	24	(	(	-LRB-
cord-290802-761wqgbe	8	25	RDRP	RDRP	NNP
cord-290802-761wqgbe	8	26	)	)	-RRB-
cord-290802-761wqgbe	8	27	,	,	,
cord-290802-761wqgbe	8	28	a	a	DT
cord-290802-761wqgbe	8	29	common	common	JJ
cord-290802-761wqgbe	8	30	conserved	conserve	VBN
cord-290802-761wqgbe	8	31	component	component	NN
cord-290802-761wqgbe	8	32	of	of	IN
cord-290802-761wqgbe	8	33	RNA	RNA	NNP
cord-290802-761wqgbe	8	34	viruses	virus	NNS
cord-290802-761wqgbe	8	35	.	.	.
cord-290802-761wqgbe	9	1	We	-PRON-	PRP
cord-290802-761wqgbe	9	2	combined	combine	VBD
cord-290802-761wqgbe	9	3	an	an	DT
cord-290802-761wqgbe	9	4	RDRP	RDRP	NNP
cord-290802-761wqgbe	9	5	structure	structure	NN
cord-290802-761wqgbe	9	6	data	datum	NNS
cord-290802-761wqgbe	9	7	set	set	NN
cord-290802-761wqgbe	9	8	,	,	,
cord-290802-761wqgbe	9	9	including	include	VBG
cord-290802-761wqgbe	9	10	384	384	CD
cord-290802-761wqgbe	9	11	RDRP	RDRP	NNP
cord-290802-761wqgbe	9	12	PDB	PDB	NNP
cord-290802-761wqgbe	9	13	structures	structure	NNS
cord-290802-761wqgbe	9	14	and	and	CC
cord-290802-761wqgbe	9	15	all	all	DT
cord-290802-761wqgbe	9	16	corresponding	correspond	VBG
cord-290802-761wqgbe	9	17	RDRP	rdrp	NN
cord-290802-761wqgbe	9	18	–	–	:
cord-290802-761wqgbe	9	19	ligand	ligand	NN
cord-290802-761wqgbe	9	20	interaction	interaction	NN
cord-290802-761wqgbe	9	21	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	9	22	,	,	,
cord-290802-761wqgbe	9	23	thereby	thereby	RB
cord-290802-761wqgbe	9	24	revealing	reveal	VBG
cord-290802-761wqgbe	9	25	the	the	DT
cord-290802-761wqgbe	9	26	structural	structural	JJ
cord-290802-761wqgbe	9	27	characteristics	characteristic	NNS
cord-290802-761wqgbe	9	28	of	of	IN
cord-290802-761wqgbe	9	29	the	the	DT
cord-290802-761wqgbe	9	30	active	active	JJ
cord-290802-761wqgbe	9	31	sites	site	NNS
cord-290802-761wqgbe	9	32	for	for	IN
cord-290802-761wqgbe	9	33	application	application	NN
cord-290802-761wqgbe	9	34	to	to	IN
cord-290802-761wqgbe	9	35	RDRP	RDRP	NNP
cord-290802-761wqgbe	9	36	-	-	HYPH
cord-290802-761wqgbe	9	37	targeted	target	VBN
cord-290802-761wqgbe	9	38	drug	drug	NN
cord-290802-761wqgbe	9	39	discovery	discovery	NN
cord-290802-761wqgbe	9	40	.	.	.
cord-290802-761wqgbe	10	1	Specifically	specifically	RB
cord-290802-761wqgbe	10	2	,	,	,
cord-290802-761wqgbe	10	3	we	-PRON-	PRP
cord-290802-761wqgbe	10	4	revealed	reveal	VBD
cord-290802-761wqgbe	10	5	the	the	DT
cord-290802-761wqgbe	10	6	intrinsic	intrinsic	JJ
cord-290802-761wqgbe	10	7	ligand	ligand	NN
cord-290802-761wqgbe	10	8	-	-	HYPH
cord-290802-761wqgbe	10	9	binding	bind	VBG
cord-290802-761wqgbe	10	10	modes	mode	NNS
cord-290802-761wqgbe	10	11	and	and	CC
cord-290802-761wqgbe	10	12	associated	associate	VBN
cord-290802-761wqgbe	10	13	RDRP	RDRP	NNP
cord-290802-761wqgbe	10	14	structural	structural	JJ
cord-290802-761wqgbe	10	15	characteristics	characteristic	NNS
cord-290802-761wqgbe	10	16	.	.	.
cord-290802-761wqgbe	11	1	Four	four	CD
cord-290802-761wqgbe	11	2	types	type	NNS
cord-290802-761wqgbe	11	3	of	of	IN
cord-290802-761wqgbe	11	4	binding	bind	VBG
cord-290802-761wqgbe	11	5	modes	mode	NNS
cord-290802-761wqgbe	11	6	with	with	IN
cord-290802-761wqgbe	11	7	corresponding	correspond	VBG
cord-290802-761wqgbe	11	8	binding	bind	VBG
cord-290802-761wqgbe	11	9	pockets	pocket	NNS
cord-290802-761wqgbe	11	10	were	be	VBD
cord-290802-761wqgbe	11	11	determined	determine	VBN
cord-290802-761wqgbe	11	12	,	,	,
cord-290802-761wqgbe	11	13	suggesting	suggest	VBG
cord-290802-761wqgbe	11	14	two	two	CD
cord-290802-761wqgbe	11	15	major	major	JJ
cord-290802-761wqgbe	11	16	subpockets	subpocket	NNS
cord-290802-761wqgbe	11	17	available	available	JJ
cord-290802-761wqgbe	11	18	for	for	IN
cord-290802-761wqgbe	11	19	drug	drug	NN
cord-290802-761wqgbe	11	20	discovery	discovery	NN
cord-290802-761wqgbe	11	21	.	.	.
cord-290802-761wqgbe	12	1	We	-PRON-	PRP
cord-290802-761wqgbe	12	2	screened	screen	VBD
cord-290802-761wqgbe	12	3	a	a	DT
cord-290802-761wqgbe	12	4	drug	drug	NN
cord-290802-761wqgbe	12	5	data	datum	NNS
cord-290802-761wqgbe	12	6	set	set	VBN
cord-290802-761wqgbe	12	7	of	of	IN
cord-290802-761wqgbe	12	8	7894	7894	CD
cord-290802-761wqgbe	12	9	compounds	compound	NNS
cord-290802-761wqgbe	12	10	against	against	IN
cord-290802-761wqgbe	12	11	these	these	DT
cord-290802-761wqgbe	12	12	binding	bind	VBG
cord-290802-761wqgbe	12	13	pockets	pocket	NNS
cord-290802-761wqgbe	12	14	and	and	CC
cord-290802-761wqgbe	12	15	presented	present	VBD
cord-290802-761wqgbe	12	16	the	the	DT
cord-290802-761wqgbe	12	17	top-10	top-10	JJ
cord-290802-761wqgbe	12	18	small	small	JJ
cord-290802-761wqgbe	12	19	molecules	molecule	NNS
cord-290802-761wqgbe	12	20	as	as	IN
cord-290802-761wqgbe	12	21	a	a	DT
cord-290802-761wqgbe	12	22	starting	starting	NN
cord-290802-761wqgbe	12	23	point	point	NN
cord-290802-761wqgbe	12	24	in	in	IN
cord-290802-761wqgbe	12	25	further	further	RB
cord-290802-761wqgbe	12	26	exploring	explore	VBG
cord-290802-761wqgbe	12	27	the	the	DT
cord-290802-761wqgbe	12	28	prevention	prevention	NN
cord-290802-761wqgbe	12	29	of	of	IN
cord-290802-761wqgbe	12	30	virus	virus	NN
cord-290802-761wqgbe	12	31	replication	replication	NN
cord-290802-761wqgbe	12	32	.	.	.
cord-290802-761wqgbe	13	1	In	in	IN
cord-290802-761wqgbe	13	2	summary	summary	NN
cord-290802-761wqgbe	13	3	,	,	,
cord-290802-761wqgbe	13	4	the	the	DT
cord-290802-761wqgbe	13	5	binding	bind	VBG
cord-290802-761wqgbe	13	6	characteristics	characteristic	NNS
cord-290802-761wqgbe	13	7	determined	determine	VBN
cord-290802-761wqgbe	13	8	here	here	RB
cord-290802-761wqgbe	13	9	help	help	VBP
cord-290802-761wqgbe	13	10	rationalize	rationalize	VB
cord-290802-761wqgbe	13	11	RDRP	RDRP	NNP
cord-290802-761wqgbe	13	12	-	-	HYPH
cord-290802-761wqgbe	13	13	targeted	target	VBN
cord-290802-761wqgbe	13	14	drug	drug	NN
cord-290802-761wqgbe	13	15	discovery	discovery	NN
cord-290802-761wqgbe	13	16	and	and	CC
cord-290802-761wqgbe	13	17	provide	provide	VB
cord-290802-761wqgbe	13	18	insights	insight	NNS
cord-290802-761wqgbe	13	19	into	into	IN
cord-290802-761wqgbe	13	20	the	the	DT
cord-290802-761wqgbe	13	21	specific	specific	JJ
cord-290802-761wqgbe	13	22	binding	binding	NN
cord-290802-761wqgbe	13	23	mechanisms	mechanism	NNS
cord-290802-761wqgbe	13	24	important	important	JJ
cord-290802-761wqgbe	13	25	for	for	IN
cord-290802-761wqgbe	13	26	containing	contain	VBG
cord-290802-761wqgbe	13	27	the	the	DT
cord-290802-761wqgbe	13	28	SARS	SARS	NNP
cord-290802-761wqgbe	13	29	-	-	HYPH
cord-290802-761wqgbe	13	30	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	13	31	virus	virus	NN
cord-290802-761wqgbe	13	32	.	.	.
cord-290802-761wqgbe	14	1	The	the	DT
cord-290802-761wqgbe	14	2	coronavirus	coronavirus	NN
cord-290802-761wqgbe	14	3	disease	disease	NN
cord-290802-761wqgbe	14	4	of	of	IN
cord-290802-761wqgbe	14	5	2019	2019	CD
cord-290802-761wqgbe	14	6	(	(	-LRB-
cord-290802-761wqgbe	14	7	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	14	8	)	)	-RRB-
cord-290802-761wqgbe	14	9	pandemic	pandemic	NN
cord-290802-761wqgbe	14	10	is	be	VBZ
cord-290802-761wqgbe	14	11	a	a	DT
cord-290802-761wqgbe	14	12	severe	severe	JJ
cord-290802-761wqgbe	14	13	threat	threat	NN
cord-290802-761wqgbe	14	14	to	to	IN
cord-290802-761wqgbe	14	15	global	global	JJ
cord-290802-761wqgbe	14	16	public	public	JJ
cord-290802-761wqgbe	14	17	health	health	NN
cord-290802-761wqgbe	14	18	,	,	,
cord-290802-761wqgbe	14	19	infecting	infect	VBG
cord-290802-761wqgbe	14	20	over	over	IN
cord-290802-761wqgbe	14	21	15	15	CD
cord-290802-761wqgbe	14	22	million	million	CD
cord-290802-761wqgbe	14	23	people	people	NNS
cord-290802-761wqgbe	14	24	,	,	,
cord-290802-761wqgbe	14	25	according	accord	VBG
cord-290802-761wqgbe	14	26	to	to	IN
cord-290802-761wqgbe	14	27	the	the	DT
cord-290802-761wqgbe	14	28	World	World	NNP
cord-290802-761wqgbe	14	29	Health	Health	NNP
cord-290802-761wqgbe	14	30	Organization	Organization	NNP
cord-290802-761wqgbe	14	31	(	(	-LRB-
cord-290802-761wqgbe	14	32	WHO	who	WP
cord-290802-761wqgbe	14	33	)	)	-RRB-
cord-290802-761wqgbe	14	34	situation	situation	NN
cord-290802-761wqgbe	14	35	report	report	NN
cord-290802-761wqgbe	14	36	.	.	.
cord-290802-761wqgbe	15	1	1	1	LS
cord-290802-761wqgbe	16	1	Consequently	consequently	RB
cord-290802-761wqgbe	16	2	,	,	,
cord-290802-761wqgbe	16	3	researchers	researcher	NNS
cord-290802-761wqgbe	16	4	have	have	VBP
cord-290802-761wqgbe	16	5	focused	focus	VBN
cord-290802-761wqgbe	16	6	on	on	IN
cord-290802-761wqgbe	16	7	developing	develop	VBG
cord-290802-761wqgbe	16	8	convenient	convenient	JJ
cord-290802-761wqgbe	16	9	testing	testing	NN
cord-290802-761wqgbe	16	10	techniques	technique	NNS
cord-290802-761wqgbe	16	11	,	,	,
cord-290802-761wqgbe	16	12	vaccines	vaccine	NNS
cord-290802-761wqgbe	16	13	,	,	,
cord-290802-761wqgbe	16	14	and	and	CC
cord-290802-761wqgbe	16	15	drug	drug	NN
cord-290802-761wqgbe	16	16	design	design	NN
cord-290802-761wqgbe	16	17	and	and	CC
cord-290802-761wqgbe	16	18	repurposing	repurpose	VBG
cord-290802-761wqgbe	16	19	to	to	TO
cord-290802-761wqgbe	16	20	mitigate	mitigate	VB
cord-290802-761wqgbe	16	21	the	the	DT
cord-290802-761wqgbe	16	22	causative	causative	JJ
cord-290802-761wqgbe	16	23	coronavirus	coronavirus	NN
cord-290802-761wqgbe	16	24	,	,	,
cord-290802-761wqgbe	16	25	severe	severe	JJ
cord-290802-761wqgbe	16	26	acute	acute	JJ
cord-290802-761wqgbe	16	27	respiratory	respiratory	JJ
cord-290802-761wqgbe	16	28	syndrome	syndrome	NN
cord-290802-761wqgbe	16	29	coronavirus	coronavirus	NN
cord-290802-761wqgbe	16	30	2	2	CD
cord-290802-761wqgbe	16	31	(	(	-LRB-
cord-290802-761wqgbe	16	32	SARS	SARS	NNP
cord-290802-761wqgbe	16	33	-	-	HYPH
cord-290802-761wqgbe	16	34	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	16	35	)	)	-RRB-
cord-290802-761wqgbe	16	36	.	.	.
cord-290802-761wqgbe	17	1	2−4	2−4	CD
cord-290802-761wqgbe	18	1	However	however	RB
cord-290802-761wqgbe	18	2	,	,	,
cord-290802-761wqgbe	18	3	to	to	IN
cord-290802-761wqgbe	18	4	date	date	NN
cord-290802-761wqgbe	18	5	,	,	,
cord-290802-761wqgbe	18	6	there	there	EX
cord-290802-761wqgbe	18	7	are	be	VBP
cord-290802-761wqgbe	18	8	no	no	DT
cord-290802-761wqgbe	18	9	effective	effective	JJ
cord-290802-761wqgbe	18	10	COVID-19specific	covid-19specific	NN
cord-290802-761wqgbe	18	11	therapeutic	therapeutic	JJ
cord-290802-761wqgbe	18	12	agents	agent	NNS
cord-290802-761wqgbe	18	13	being	be	VBG
cord-290802-761wqgbe	18	14	prescribed	prescribe	VBN
cord-290802-761wqgbe	18	15	.	.	.
cord-290802-761wqgbe	19	1	Laboratory	laboratory	NN
cord-290802-761wqgbe	19	2	testing	testing	NN
cord-290802-761wqgbe	19	3	techniques	technique	NNS
cord-290802-761wqgbe	19	4	have	have	VBP
cord-290802-761wqgbe	19	5	made	make	VBN
cord-290802-761wqgbe	19	6	breakthroughs	breakthrough	NNS
cord-290802-761wqgbe	19	7	:	:	:
cord-290802-761wqgbe	19	8	the	the	DT
cord-290802-761wqgbe	19	9	Food	Food	NNP
cord-290802-761wqgbe	19	10	and	and	CC
cord-290802-761wqgbe	19	11	Drug	Drug	NNP
cord-290802-761wqgbe	19	12	Administration	Administration	NNP
cord-290802-761wqgbe	19	13	has	have	VBZ
cord-290802-761wqgbe	19	14	recently	recently	RB
cord-290802-761wqgbe	19	15	granted	grant	VBN
cord-290802-761wqgbe	19	16	an	an	DT
cord-290802-761wqgbe	19	17	emergency	emergency	NN
cord-290802-761wqgbe	19	18	use	use	NN
cord-290802-761wqgbe	19	19	authorization	authorization	NN
cord-290802-761wqgbe	19	20	for	for	IN
cord-290802-761wqgbe	19	21	the	the	DT
cord-290802-761wqgbe	19	22	Sofia	Sofia	NNP
cord-290802-761wqgbe	19	23	2	2	CD
cord-290802-761wqgbe	19	24	SARS	SARS	NNP
cord-290802-761wqgbe	19	25	Antigen	Antigen	NNP
cord-290802-761wqgbe	19	26	FIA	FIA	NNP
cord-290802-761wqgbe	19	27	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	19	28	test	test	NN
cord-290802-761wqgbe	19	29	,	,	,
cord-290802-761wqgbe	19	30	5	5	CD
cord-290802-761wqgbe	19	31	which	which	WDT
cord-290802-761wqgbe	19	32	can	can	MD
cord-290802-761wqgbe	19	33	detect	detect	VB
cord-290802-761wqgbe	19	34	the	the	DT
cord-290802-761wqgbe	19	35	virus	virus	NN
cord-290802-761wqgbe	19	36	within	within	IN
cord-290802-761wqgbe	19	37	minutes	minute	NNS
cord-290802-761wqgbe	19	38	.	.	.
cord-290802-761wqgbe	20	1	Progress	progress	VB
cord-290802-761wqgbe	20	2	in	in	IN
cord-290802-761wqgbe	20	3	detection	detection	NN
cord-290802-761wqgbe	20	4	is	be	VBZ
cord-290802-761wqgbe	20	5	important	important	JJ
cord-290802-761wqgbe	20	6	,	,	,
cord-290802-761wqgbe	20	7	but	but	CC
cord-290802-761wqgbe	20	8	it	-PRON-	PRP
cord-290802-761wqgbe	20	9	does	do	VBZ
cord-290802-761wqgbe	20	10	not	not	RB
cord-290802-761wqgbe	20	11	speak	speak	VB
cord-290802-761wqgbe	20	12	to	to	IN
cord-290802-761wqgbe	20	13	a	a	DT
cord-290802-761wqgbe	20	14	treatment	treatment	NN
cord-290802-761wqgbe	20	15	;	;	:
cord-290802-761wqgbe	20	16	hence	hence	RB
cord-290802-761wqgbe	20	17	,	,	,
cord-290802-761wqgbe	20	18	the	the	DT
cord-290802-761wqgbe	20	19	research	research	NN
cord-290802-761wqgbe	20	20	community	community	NN
cord-290802-761wqgbe	20	21	is	be	VBZ
cord-290802-761wqgbe	20	22	developing	develop	VBG
cord-290802-761wqgbe	20	23	specialized	specialized	JJ
cord-290802-761wqgbe	20	24	SARS	SARS	NNP
cord-290802-761wqgbe	20	25	-	-	HYPH
cord-290802-761wqgbe	20	26	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	20	27	vaccines	vaccine	NNS
cord-290802-761wqgbe	20	28	and	and	CC
cord-290802-761wqgbe	20	29	drugs	drug	NNS
cord-290802-761wqgbe	20	30	to	to	TO
cord-290802-761wqgbe	20	31	mitigate	mitigate	VB
cord-290802-761wqgbe	20	32	and	and	CC
cord-290802-761wqgbe	20	33	treat	treat	VB
cord-290802-761wqgbe	20	34	the	the	DT
cord-290802-761wqgbe	20	35	pandemic	pandemic	NN
cord-290802-761wqgbe	20	36	.	.	.
cord-290802-761wqgbe	21	1	6	6	CD
cord-290802-761wqgbe	21	2	Drug	drug	NN
cord-290802-761wqgbe	21	3	discovery	discovery	NN
cord-290802-761wqgbe	21	4	is	be	VBZ
cord-290802-761wqgbe	21	5	thwarted	thwart	VBN
cord-290802-761wqgbe	21	6	by	by	IN
cord-290802-761wqgbe	21	7	the	the	DT
cord-290802-761wqgbe	21	8	multiple	multiple	JJ
cord-290802-761wqgbe	21	9	mutations	mutation	NNS
cord-290802-761wqgbe	21	10	found	find	VBN
cord-290802-761wqgbe	21	11	in	in	IN
cord-290802-761wqgbe	21	12	the	the	DT
cord-290802-761wqgbe	21	13	SARS	SARS	NNP
cord-290802-761wqgbe	21	14	-	-	HYPH
cord-290802-761wqgbe	21	15	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	21	16	family	family	NN
cord-290802-761wqgbe	21	17	.	.	.
cord-290802-761wqgbe	22	1	7	7	CD
cord-290802-761wqgbe	22	2	Three	three	CD
cord-290802-761wqgbe	22	3	distinct	distinct	JJ
cord-290802-761wqgbe	22	4	"	"	``
cord-290802-761wqgbe	22	5	variants	variant	NNS
cord-290802-761wqgbe	22	6	"	"	''
cord-290802-761wqgbe	22	7	from	from	IN
cord-290802-761wqgbe	22	8	the	the	DT
cord-290802-761wqgbe	22	9	SARS	SARS	NNP
cord-290802-761wqgbe	22	10	-	-	HYPH
cord-290802-761wqgbe	22	11	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	22	12	genomes	genome	NNS
cord-290802-761wqgbe	22	13	sampled	sample	VBD
cord-290802-761wqgbe	22	14	7	7	CD
cord-290802-761wqgbe	22	15	between	between	IN
cord-290802-761wqgbe	22	16	December	December	NNP
cord-290802-761wqgbe	22	17	24	24	CD
cord-290802-761wqgbe	22	18	,	,	,
cord-290802-761wqgbe	22	19	2019	2019	CD
cord-290802-761wqgbe	22	20	,	,	,
cord-290802-761wqgbe	22	21	and	and	CC
cord-290802-761wqgbe	22	22	March	March	NNP
cord-290802-761wqgbe	22	23	4	4	CD
cord-290802-761wqgbe	22	24	,	,	,
cord-290802-761wqgbe	22	25	2020	2020	CD
cord-290802-761wqgbe	22	26	,	,	,
cord-290802-761wqgbe	22	27	have	have	VBP
cord-290802-761wqgbe	22	28	been	be	VBN
cord-290802-761wqgbe	22	29	reported	report	VBN
cord-290802-761wqgbe	22	30	.	.	.
cord-290802-761wqgbe	23	1	Thus	thus	RB
cord-290802-761wqgbe	23	2	,	,	,
cord-290802-761wqgbe	23	3	it	-PRON-	PRP
cord-290802-761wqgbe	23	4	is	be	VBZ
cord-290802-761wqgbe	23	5	challenging	challenge	VBG
cord-290802-761wqgbe	23	6	to	to	TO
cord-290802-761wqgbe	23	7	design	design	VB
cord-290802-761wqgbe	23	8	novel	novel	NN
cord-290802-761wqgbe	23	9	COVID-19	covid-19	CD
cord-290802-761wqgbe	23	10	medications	medication	NNS
cord-290802-761wqgbe	23	11	,	,	,
cord-290802-761wqgbe	23	12	which	which	WDT
cord-290802-761wqgbe	23	13	not	not	RB
cord-290802-761wqgbe	23	14	only	only	RB
cord-290802-761wqgbe	23	15	are	be	VBP
cord-290802-761wqgbe	23	16	effective	effective	JJ
cord-290802-761wqgbe	23	17	but	but	CC
cord-290802-761wqgbe	23	18	also	also	RB
cord-290802-761wqgbe	23	19	remain	remain	VBP
cord-290802-761wqgbe	23	20	so	so	RB
cord-290802-761wqgbe	23	21	given	give	VBN
cord-290802-761wqgbe	23	22	the	the	DT
cord-290802-761wqgbe	23	23	mutation	mutation	NN
cord-290802-761wqgbe	23	24	rate	rate	NN
cord-290802-761wqgbe	23	25	.	.	.
cord-290802-761wqgbe	24	1	Scientists	scientist	NNS
cord-290802-761wqgbe	24	2	have	have	VBP
cord-290802-761wqgbe	24	3	established	establish	VBN
cord-290802-761wqgbe	24	4	SARS	SARS	NNP
cord-290802-761wqgbe	24	5	-	-	HYPH
cord-290802-761wqgbe	24	6	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	24	7	as	as	IN
cord-290802-761wqgbe	24	8	an	an	DT
cord-290802-761wqgbe	24	9	RNA	RNA	NNP
cord-290802-761wqgbe	24	10	virus	virus	NN
cord-290802-761wqgbe	24	11	containing	contain	VBG
cord-290802-761wqgbe	24	12	a	a	DT
cord-290802-761wqgbe	24	13	single	single	RB
cord-290802-761wqgbe	24	14	-	-	HYPH
cord-290802-761wqgbe	24	15	stranded	strand	VBN
cord-290802-761wqgbe	24	16	positive	positive	JJ
cord-290802-761wqgbe	24	17	-	-	HYPH
cord-290802-761wqgbe	24	18	sense	sense	NN
cord-290802-761wqgbe	24	19	RNA	RNA	NNP
cord-290802-761wqgbe	24	20	genome	genome	NN
cord-290802-761wqgbe	24	21	.	.	.
cord-290802-761wqgbe	25	1	2	2	LS
cord-290802-761wqgbe	26	1	RNA	RNA	NNP
cord-290802-761wqgbe	26	2	viruses	virus	NNS
cord-290802-761wqgbe	26	3	have	have	VBP
cord-290802-761wqgbe	26	4	been	be	VBN
cord-290802-761wqgbe	26	5	the	the	DT
cord-290802-761wqgbe	26	6	main	main	JJ
cord-290802-761wqgbe	26	7	cause	cause	NN
cord-290802-761wqgbe	26	8	of	of	IN
cord-290802-761wqgbe	26	9	epidemics	epidemic	NNS
cord-290802-761wqgbe	26	10	over	over	IN
cord-290802-761wqgbe	26	11	the	the	DT
cord-290802-761wqgbe	26	12	last	last	JJ
cord-290802-761wqgbe	26	13	two	two	CD
cord-290802-761wqgbe	26	14	decades	decade	NNS
cord-290802-761wqgbe	26	15	:	:	:
cord-290802-761wqgbe	26	16	SARS	SARS	NNP
cord-290802-761wqgbe	26	17	8	8	CD
cord-290802-761wqgbe	26	18	in	in	IN
cord-290802-761wqgbe	26	19	2003	2003	CD
cord-290802-761wqgbe	26	20	,	,	,
cord-290802-761wqgbe	26	21	MERS	MERS	NNP
cord-290802-761wqgbe	26	22	9	9	CD
cord-290802-761wqgbe	26	23	in	in	IN
cord-290802-761wqgbe	26	24	2012	2012	CD
cord-290802-761wqgbe	26	25	,	,	,
cord-290802-761wqgbe	26	26	Ebola	Ebola	NNP
cord-290802-761wqgbe	26	27	10	10	CD
cord-290802-761wqgbe	26	28	in	in	IN
cord-290802-761wqgbe	26	29	2014	2014	CD
cord-290802-761wqgbe	26	30	,	,	,
cord-290802-761wqgbe	26	31	Zika	Zika	NNP
cord-290802-761wqgbe	26	32	11	11	CD
cord-290802-761wqgbe	26	33	,	,	,
cord-290802-761wqgbe	26	34	12	12	CD
cord-290802-761wqgbe	26	35	in	in	IN
cord-290802-761wqgbe	26	36	2015	2015	CD
cord-290802-761wqgbe	26	37	,	,	,
cord-290802-761wqgbe	26	38	and	and	CC
cord-290802-761wqgbe	26	39	now	now	RB
cord-290802-761wqgbe	26	40	COVID-19	covid-19	VB
cord-290802-761wqgbe	26	41	.	.	.
cord-290802-761wqgbe	27	1	RNA	RNA	NNP
cord-290802-761wqgbe	27	2	viruses	virus	NNS
cord-290802-761wqgbe	27	3	are	be	VBP
cord-290802-761wqgbe	27	4	divided	divide	VBN
cord-290802-761wqgbe	27	5	into	into	IN
cord-290802-761wqgbe	27	6	4	4	CD
cord-290802-761wqgbe	27	7	classes	class	NNS
cord-290802-761wqgbe	27	8	:	:	:
cord-290802-761wqgbe	27	9	3	3	CD
cord-290802-761wqgbe	27	10	single	single	JJ
cord-290802-761wqgbe	27	11	positive	positive	JJ
cord-290802-761wqgbe	27	12	-	-	HYPH
cord-290802-761wqgbe	27	13	strand	strand	NN
cord-290802-761wqgbe	27	14	RNA	RNA	NNP
cord-290802-761wqgbe	27	15	(	(	-LRB-
cord-290802-761wqgbe	27	16	(	(	-LRB-
cord-290802-761wqgbe	27	17	+	+	JJ
cord-290802-761wqgbe	27	18	)	)	-RRB-
cord-290802-761wqgbe	27	19	-ssRNA	-ssRNA	NFP
cord-290802-761wqgbe	27	20	)	)	-RRB-
cord-290802-761wqgbe	27	21	such	such	JJ
cord-290802-761wqgbe	27	22	as	as	IN
cord-290802-761wqgbe	27	23	SARS	SARS	NNP
cord-290802-761wqgbe	27	24	,	,	,
cord-290802-761wqgbe	27	25	MERS	MERS	NNP
cord-290802-761wqgbe	27	26	,	,	,
cord-290802-761wqgbe	27	27	and	and	CC
cord-290802-761wqgbe	27	28	SARS	SARS	NNP
cord-290802-761wqgbe	27	29	-	-	HYPH
cord-290802-761wqgbe	27	30	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	27	31	;	;	:
cord-290802-761wqgbe	27	32	single	single	JJ
cord-290802-761wqgbe	27	33	negative	negative	JJ
cord-290802-761wqgbe	27	34	-	-	HYPH
cord-290802-761wqgbe	27	35	strand	strand	NN
cord-290802-761wqgbe	27	36	RNA	RNA	NNP
cord-290802-761wqgbe	27	37	(	(	-LRB-
cord-290802-761wqgbe	27	38	(	(	-LRB-
cord-290802-761wqgbe	27	39	−)ssRNA	−)ssrna	LS
cord-290802-761wqgbe	27	40	)	)	-RRB-
cord-290802-761wqgbe	27	41	such	such	JJ
cord-290802-761wqgbe	27	42	as	as	IN
cord-290802-761wqgbe	27	43	Ebola	Ebola	NNP
cord-290802-761wqgbe	27	44	;	;	,
cord-290802-761wqgbe	27	45	doublestrand	doublestrand	NNP
cord-290802-761wqgbe	27	46	RNA	RNA	NNP
cord-290802-761wqgbe	27	47	(	(	-LRB-
cord-290802-761wqgbe	27	48	dsRNA	dsrna	NN
cord-290802-761wqgbe	27	49	)	)	-RRB-
cord-290802-761wqgbe	27	50	;	;	:
cord-290802-761wqgbe	27	51	and	and	CC
cord-290802-761wqgbe	27	52	retroviruses	retrovirus	NNS
cord-290802-761wqgbe	27	53	such	such	JJ
cord-290802-761wqgbe	27	54	as	as	IN
cord-290802-761wqgbe	27	55	HIV	HIV	NNP
cord-290802-761wqgbe	27	56	.	.	.
cord-290802-761wqgbe	28	1	13	13	CD
cord-290802-761wqgbe	28	2	,	,	,
cord-290802-761wqgbe	28	3	14	14	CD
cord-290802-761wqgbe	29	1	These	these	DT
cord-290802-761wqgbe	29	2	viruses	virus	NNS
cord-290802-761wqgbe	29	3	replicate	replicate	VBP
cord-290802-761wqgbe	29	4	their	-PRON-	PRP$
cord-290802-761wqgbe	29	5	genetic	genetic	JJ
cord-290802-761wqgbe	29	6	material	material	NN
cord-290802-761wqgbe	29	7	within	within	IN
cord-290802-761wqgbe	29	8	host	host	NN
cord-290802-761wqgbe	29	9	cells	cell	NNS
cord-290802-761wqgbe	29	10	;	;	:
cord-290802-761wqgbe	29	11	15	15	CD
cord-290802-761wqgbe	29	12	hence	hence	RB
cord-290802-761wqgbe	29	13	,	,	,
cord-290802-761wqgbe	29	14	one	one	CD
cord-290802-761wqgbe	29	15	way	way	NN
cord-290802-761wqgbe	29	16	to	to	TO
cord-290802-761wqgbe	29	17	limit	limit	VB
cord-290802-761wqgbe	29	18	infection	infection	NN
cord-290802-761wqgbe	29	19	is	be	VBZ
cord-290802-761wqgbe	29	20	to	to	TO
cord-290802-761wqgbe	29	21	inhibit	inhibit	VB
cord-290802-761wqgbe	29	22	virus	virus	NN
cord-290802-761wqgbe	29	23	replication	replication	NN
cord-290802-761wqgbe	29	24	.	.	.
cord-290802-761wqgbe	30	1	Apart	apart	RB
cord-290802-761wqgbe	30	2	from	from	IN
cord-290802-761wqgbe	30	3	retroviruses	retrovirus	NNS
cord-290802-761wqgbe	30	4	,	,	,
cord-290802-761wqgbe	30	5	the	the	DT
cord-290802-761wqgbe	30	6	other	other	JJ
cord-290802-761wqgbe	30	7	classes	class	NNS
cord-290802-761wqgbe	30	8	all	all	PDT
cord-290802-761wqgbe	30	9	This	this	DT
cord-290802-761wqgbe	30	10	article	article	NN
cord-290802-761wqgbe	30	11	is	be	VBZ
cord-290802-761wqgbe	30	12	made	make	VBN
cord-290802-761wqgbe	30	13	available	available	JJ
cord-290802-761wqgbe	30	14	via	via	IN
cord-290802-761wqgbe	31	1	the	the	DT
cord-290802-761wqgbe	31	2	ACS	ACS	NNP
cord-290802-761wqgbe	31	3	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	31	4	subset	subset	VBN
cord-290802-761wqgbe	31	5	for	for	IN
cord-290802-761wqgbe	31	6	unrestricted	unrestricted	JJ
cord-290802-761wqgbe	31	7	RESEARCH	research	NN
cord-290802-761wqgbe	31	8	re	re	NN
cord-290802-761wqgbe	31	9	-	-	NN
cord-290802-761wqgbe	31	10	use	use	NN
cord-290802-761wqgbe	31	11	and	and	CC
cord-290802-761wqgbe	31	12	analyses	analysis	NNS
cord-290802-761wqgbe	31	13	in	in	IN
cord-290802-761wqgbe	31	14	any	any	DT
cord-290802-761wqgbe	31	15	form	form	NN
cord-290802-761wqgbe	31	16	or	or	CC
cord-290802-761wqgbe	31	17	by	by	IN
cord-290802-761wqgbe	31	18	any	any	DT
cord-290802-761wqgbe	31	19	means	mean	NNS
cord-290802-761wqgbe	31	20	with	with	IN
cord-290802-761wqgbe	31	21	acknowledgement	acknowledgement	NN
cord-290802-761wqgbe	31	22	of	of	IN
cord-290802-761wqgbe	31	23	the	the	DT
cord-290802-761wqgbe	31	24	original	original	JJ
cord-290802-761wqgbe	31	25	source	source	NN
cord-290802-761wqgbe	31	26	.	.	.
cord-290802-761wqgbe	32	1	These	these	DT
cord-290802-761wqgbe	32	2	permissions	permission	NNS
cord-290802-761wqgbe	32	3	are	be	VBP
cord-290802-761wqgbe	32	4	granted	grant	VBN
cord-290802-761wqgbe	32	5	for	for	IN
cord-290802-761wqgbe	32	6	the	the	DT
cord-290802-761wqgbe	32	7	duration	duration	NN
cord-290802-761wqgbe	32	8	of	of	IN
cord-290802-761wqgbe	32	9	the	the	DT
cord-290802-761wqgbe	32	10	World	World	NNP
cord-290802-761wqgbe	32	11	Health	Health	NNP
cord-290802-761wqgbe	32	12	Organization	Organization	NNP
cord-290802-761wqgbe	32	13	(	(	-LRB-
cord-290802-761wqgbe	32	14	WHO	who	WP
cord-290802-761wqgbe	32	15	)	)	-RRB-
cord-290802-761wqgbe	32	16	declaration	declaration	NN
cord-290802-761wqgbe	32	17	of	of	IN
cord-290802-761wqgbe	32	18	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	32	19	as	as	IN
cord-290802-761wqgbe	32	20	a	a	DT
cord-290802-761wqgbe	32	21	global	global	JJ
cord-290802-761wqgbe	32	22	pandemic	pandemic	NN
cord-290802-761wqgbe	32	23	.	.	.
cord-290802-761wqgbe	33	1	contain	contain	VB
cord-290802-761wqgbe	33	2	a	a	DT
cord-290802-761wqgbe	33	3	common	common	JJ
cord-290802-761wqgbe	33	4	RNA	rna	NN
cord-290802-761wqgbe	33	5	-	-	HYPH
cord-290802-761wqgbe	33	6	dependent	dependent	JJ
cord-290802-761wqgbe	33	7	RNA	RNA	NNP
cord-290802-761wqgbe	33	8	polymerase	polymerase	NN
cord-290802-761wqgbe	33	9	(	(	-LRB-
cord-290802-761wqgbe	33	10	RDRP	RDRP	NNP
cord-290802-761wqgbe	33	11	)	)	-RRB-
cord-290802-761wqgbe	33	12	,	,	,
cord-290802-761wqgbe	33	13	16	16	CD
cord-290802-761wqgbe	33	14	which	which	WDT
cord-290802-761wqgbe	33	15	catalyzes	catalyze	VBZ
cord-290802-761wqgbe	33	16	the	the	DT
cord-290802-761wqgbe	33	17	replication	replication	NN
cord-290802-761wqgbe	33	18	of	of	IN
cord-290802-761wqgbe	33	19	viral	viral	JJ
cord-290802-761wqgbe	33	20	RNA	RNA	NNP
cord-290802-761wqgbe	33	21	and	and	CC
cord-290802-761wqgbe	33	22	hence	hence	RB
cord-290802-761wqgbe	33	23	is	be	VBZ
cord-290802-761wqgbe	33	24	a	a	DT
cord-290802-761wqgbe	33	25	prime	prime	JJ
cord-290802-761wqgbe	33	26	drug	drug	NN
cord-290802-761wqgbe	33	27	target	target	NN
cord-290802-761wqgbe	33	28	.	.	.
cord-290802-761wqgbe	34	1	Multiple	multiple	JJ
cord-290802-761wqgbe	34	2	high	high	JJ
cord-290802-761wqgbe	34	3	-	-	HYPH
cord-290802-761wqgbe	34	4	resolution	resolution	NN
cord-290802-761wqgbe	34	5	RDRP	RDRP	NNP
cord-290802-761wqgbe	34	6	3D	3d	JJ
cord-290802-761wqgbe	34	7	structures	structure	NNS
cord-290802-761wqgbe	34	8	have	have	VBP
cord-290802-761wqgbe	34	9	been	be	VBN
cord-290802-761wqgbe	34	10	solved	solve	VBN
cord-290802-761wqgbe	34	11	,	,	,
cord-290802-761wqgbe	34	12	each	each	DT
cord-290802-761wqgbe	34	13	with	with	IN
cord-290802-761wqgbe	34	14	a	a	DT
cord-290802-761wqgbe	34	15	similar	similar	JJ
cord-290802-761wqgbe	34	16	core	core	NN
cord-290802-761wqgbe	34	17	architecture	architecture	NN
cord-290802-761wqgbe	34	18	,	,	,
cord-290802-761wqgbe	34	19	17	17	CD
cord-290802-761wqgbe	34	20	namely	namely	RB
cord-290802-761wqgbe	34	21	a	a	DT
cord-290802-761wqgbe	34	22	"	"	``
cord-290802-761wqgbe	34	23	cupped	cup	VBN
cord-290802-761wqgbe	34	24	right	right	JJ
cord-290802-761wqgbe	34	25	hand	hand	NN
cord-290802-761wqgbe	34	26	"	"	''
cord-290802-761wqgbe	34	27	with	with	IN
cord-290802-761wqgbe	34	28	7	7	CD
cord-290802-761wqgbe	34	29	motifs	motif	NNS
cord-290802-761wqgbe	34	30	(	(	-LRB-
cord-290802-761wqgbe	34	31	A−G	A−G	NNP
cord-290802-761wqgbe	34	32	)	)	-RRB-
cord-290802-761wqgbe	34	33	comprising	comprise	VBG
cord-290802-761wqgbe	34	34	"	"	``
cord-290802-761wqgbe	34	35	palm	palm	NN
cord-290802-761wqgbe	34	36	"	"	''
cord-290802-761wqgbe	34	37	,	,	,
cord-290802-761wqgbe	34	38	"	"	``
cord-290802-761wqgbe	34	39	fingers	finger	NNS
cord-290802-761wqgbe	34	40	"	"	''
cord-290802-761wqgbe	34	41	,	,	,
cord-290802-761wqgbe	34	42	and	and	CC
cord-290802-761wqgbe	34	43	"	"	``
cord-290802-761wqgbe	34	44	thumb	thumb	NN
cord-290802-761wqgbe	34	45	"	"	''
cord-290802-761wqgbe	34	46	(	(	-LRB-
cord-290802-761wqgbe	34	47	Figure	figure	NN
cord-290802-761wqgbe	34	48	1	1	CD
cord-290802-761wqgbe	34	49	and	and	CC
cord-290802-761wqgbe	34	50	Table	Table	NNP
cord-290802-761wqgbe	34	51	S1	S1	NNP
cord-290802-761wqgbe	34	52	)	)	-RRB-
cord-290802-761wqgbe	34	53	.	.	.
cord-290802-761wqgbe	35	1	18	18	CD
cord-290802-761wqgbe	35	2	,	,	,
cord-290802-761wqgbe	35	3	19	19	CD
cord-290802-761wqgbe	36	1	Here	here	RB
cord-290802-761wqgbe	36	2	,	,	,
cord-290802-761wqgbe	36	3	we	-PRON-	PRP
cord-290802-761wqgbe	36	4	propose	propose	VBP
cord-290802-761wqgbe	36	5	a	a	DT
cord-290802-761wqgbe	36	6	drug	drug	NN
cord-290802-761wqgbe	36	7	discovery	discovery	NN
cord-290802-761wqgbe	36	8	scheme	scheme	NN
cord-290802-761wqgbe	36	9	targeting	target	VBG
cord-290802-761wqgbe	36	10	the	the	DT
cord-290802-761wqgbe	36	11	conserved	conserve	VBN
cord-290802-761wqgbe	36	12	RDRP	rdrp	NN
cord-290802-761wqgbe	36	13	.	.	.
cord-290802-761wqgbe	37	1	On	on	IN
cord-290802-761wqgbe	37	2	April	April	NNP
cord-290802-761wqgbe	37	3	29	29	CD
cord-290802-761wqgbe	37	4	,	,	,
cord-290802-761wqgbe	37	5	2020	2020	CD
cord-290802-761wqgbe	37	6	,	,	,
cord-290802-761wqgbe	37	7	the	the	DT
cord-290802-761wqgbe	37	8	National	National	NNP
cord-290802-761wqgbe	37	9	Institutes	Institutes	NNPS
cord-290802-761wqgbe	37	10	of	of	IN
cord-290802-761wqgbe	37	11	Health	Health	NNP
cord-290802-761wqgbe	37	12	(	(	-LRB-
cord-290802-761wqgbe	37	13	NIH	NIH	NNP
cord-290802-761wqgbe	37	14	)	)	-RRB-
cord-290802-761wqgbe	37	15	indicated	indicate	VBD
cord-290802-761wqgbe	37	16	that	that	IN
cord-290802-761wqgbe	37	17	the	the	DT
cord-290802-761wqgbe	37	18	repurposed	repurpose	VBN
cord-290802-761wqgbe	37	19	drug	drug	NN
cord-290802-761wqgbe	37	20	remdesivir	remdesivir	NNP
cord-290802-761wqgbe	37	21	,	,	,
cord-290802-761wqgbe	37	22	targeting	target	VBG
cord-290802-761wqgbe	37	23	RDRP	RDRP	NNP
cord-290802-761wqgbe	37	24	,	,	,
cord-290802-761wqgbe	37	25	shortened	shorten	VBD
cord-290802-761wqgbe	37	26	patients	patient	NNS
cord-290802-761wqgbe	37	27	'	'	POS
cord-290802-761wqgbe	37	28	time	time	NN
cord-290802-761wqgbe	37	29	to	to	IN
cord-290802-761wqgbe	37	30	recovery	recovery	NN
cord-290802-761wqgbe	37	31	by	by	IN
cord-290802-761wqgbe	37	32	4	4	CD
cord-290802-761wqgbe	37	33	days	day	NNS
cord-290802-761wqgbe	37	34	,	,	,
cord-290802-761wqgbe	37	35	or	or	CC
cord-290802-761wqgbe	37	36	31	31	CD
cord-290802-761wqgbe	37	37	%	%	NN
cord-290802-761wqgbe	37	38	.	.	.
cord-290802-761wqgbe	38	1	However	however	RB
cord-290802-761wqgbe	38	2	,	,	,
cord-290802-761wqgbe	38	3	remdesivir	remdesivir	NNP
cord-290802-761wqgbe	38	4	did	do	VBD
cord-290802-761wqgbe	38	5	not	not	RB
cord-290802-761wqgbe	38	6	show	show	VB
cord-290802-761wqgbe	38	7	significant	significant	JJ
cord-290802-761wqgbe	38	8	efficacy	efficacy	NN
cord-290802-761wqgbe	38	9	in	in	IN
cord-290802-761wqgbe	38	10	reducing	reduce	VBG
cord-290802-761wqgbe	38	11	mortality	mortality	NN
cord-290802-761wqgbe	38	12	,	,	,
cord-290802-761wqgbe	38	13	20	20	CD
cord-290802-761wqgbe	38	14	but	but	CC
cord-290802-761wqgbe	38	15	it	-PRON-	PRP
cord-290802-761wqgbe	38	16	is	be	VBZ
cord-290802-761wqgbe	38	17	a	a	DT
cord-290802-761wqgbe	38	18	start	start	NN
cord-290802-761wqgbe	38	19	in	in	IN
cord-290802-761wqgbe	38	20	the	the	DT
cord-290802-761wqgbe	38	21	quest	quest	NN
cord-290802-761wqgbe	38	22	for	for	IN
cord-290802-761wqgbe	38	23	RDRPtargeted	rdrptargete	VBN
cord-290802-761wqgbe	38	24	drugs	drug	NNS
cord-290802-761wqgbe	38	25	.	.	.
cord-290802-761wqgbe	39	1	Here	here	RB
cord-290802-761wqgbe	39	2	,	,	,
cord-290802-761wqgbe	39	3	we	-PRON-	PRP
cord-290802-761wqgbe	39	4	advance	advance	VBP
cord-290802-761wqgbe	39	5	anti	anti	JJ
cord-290802-761wqgbe	39	6	-	-	JJ
cord-290802-761wqgbe	39	7	COVID-19	covid-19	JJ
cord-290802-761wqgbe	39	8	drug	drug	NN
cord-290802-761wqgbe	39	9	research	research	NN
cord-290802-761wqgbe	39	10	and	and	CC
cord-290802-761wqgbe	39	11	development	development	NN
cord-290802-761wqgbe	39	12	by	by	IN
cord-290802-761wqgbe	39	13	revealing	reveal	VBG
cord-290802-761wqgbe	39	14	new	new	JJ
cord-290802-761wqgbe	39	15	features	feature	NNS
cord-290802-761wqgbe	39	16	of	of	IN
cord-290802-761wqgbe	39	17	drug	drug	NN
cord-290802-761wqgbe	39	18	binding	bind	VBG
cord-290802-761wqgbe	39	19	to	to	IN
cord-290802-761wqgbe	39	20	RDRP	RDRP	NNP
cord-290802-761wqgbe	39	21	using	use	VBG
cord-290802-761wqgbe	39	22	a	a	DT
cord-290802-761wqgbe	39	23	computational	computational	JJ
cord-290802-761wqgbe	39	24	pharmacology	pharmacology	NN
cord-290802-761wqgbe	39	25	approach	approach	NN
cord-290802-761wqgbe	39	26	.	.	.
cord-290802-761wqgbe	40	1	We	-PRON-	PRP
cord-290802-761wqgbe	40	2	collected	collect	VBD
cord-290802-761wqgbe	40	3	384	384	CD
cord-290802-761wqgbe	40	4	PDB	PDB	NNP
cord-290802-761wqgbe	40	5	structures	structure	NNS
cord-290802-761wqgbe	40	6	of	of	IN
cord-290802-761wqgbe	40	7	RDRP	rdrp	NN
cord-290802-761wqgbe	40	8	catalytic	catalytic	JJ
cord-290802-761wqgbe	40	9	domains	domain	NNS
cord-290802-761wqgbe	40	10	and	and	CC
cord-290802-761wqgbe	40	11	their	-PRON-	PRP$
cord-290802-761wqgbe	40	12	complexes	complex	NNS
cord-290802-761wqgbe	40	13	(	(	-LRB-
cord-290802-761wqgbe	40	14	available	available	JJ
cord-290802-761wqgbe	40	15	as	as	IN
cord-290802-761wqgbe	40	16	of	of	IN
cord-290802-761wqgbe	40	17	July	July	NNP
cord-290802-761wqgbe	40	18	1	1	CD
cord-290802-761wqgbe	40	19	,	,	,
cord-290802-761wqgbe	40	20	2020	2020	CD
cord-290802-761wqgbe	40	21	)	)	-RRB-
cord-290802-761wqgbe	40	22	from	from	IN
cord-290802-761wqgbe	40	23	47	47	CD
cord-290802-761wqgbe	40	24	RNA	RNA	NNP
cord-290802-761wqgbe	40	25	viruses	virus	NNS
cord-290802-761wqgbe	40	26	,	,	,
cord-290802-761wqgbe	40	27	including	include	VBG
cord-290802-761wqgbe	40	28	coronavirus	coronavirus	NN
cord-290802-761wqgbe	40	29	,	,	,
cord-290802-761wqgbe	40	30	as	as	IN
cord-290802-761wqgbe	40	31	our	-PRON-	PRP$
cord-290802-761wqgbe	40	32	RDRP	RDRP	NNP
cord-290802-761wqgbe	40	33	data	datum	NNS
cord-290802-761wqgbe	40	34	set	set	NN
cord-290802-761wqgbe	40	35	(	(	-LRB-
cord-290802-761wqgbe	40	36	see	see	VB
cord-290802-761wqgbe	40	37	Methods	Methods	NNPS
cord-290802-761wqgbe	40	38	)	)	-RRB-
cord-290802-761wqgbe	40	39	.	.	.
cord-290802-761wqgbe	41	1	Then	then	RB
cord-290802-761wqgbe	41	2	,	,	,
cord-290802-761wqgbe	41	3	using	use	VBG
cord-290802-761wqgbe	41	4	computational	computational	JJ
cord-290802-761wqgbe	41	5	pharmacology	pharmacology	NN
cord-290802-761wqgbe	41	6	methods	method	NNS
cord-290802-761wqgbe	41	7	,	,	,
cord-290802-761wqgbe	41	8	notably	notably	RB
cord-290802-761wqgbe	41	9	a	a	DT
cord-290802-761wqgbe	41	10	function	function	NN
cord-290802-761wqgbe	41	11	-	-	HYPH
cord-290802-761wqgbe	41	12	site	site	NN
cord-290802-761wqgbe	41	13	interaction	interaction	NN
cord-290802-761wqgbe	41	14	fingerprint	fingerprint	NN
cord-290802-761wqgbe	41	15	method	method	NN
cord-290802-761wqgbe	41	16	,	,	,
cord-290802-761wqgbe	41	17	we	-PRON-	PRP
cord-290802-761wqgbe	41	18	characterized	characterize	VBD
cord-290802-761wqgbe	41	19	the	the	DT
cord-290802-761wqgbe	41	20	RDRP−ligand	rdrp−ligand	NN
cord-290802-761wqgbe	41	21	interactions	interaction	NNS
cord-290802-761wqgbe	41	22	to	to	TO
cord-290802-761wqgbe	41	23	provide	provide	VB
cord-290802-761wqgbe	41	24	new	new	JJ
cord-290802-761wqgbe	41	25	insights	insight	NNS
cord-290802-761wqgbe	41	26	into	into	IN
cord-290802-761wqgbe	41	27	antiviral	antiviral	JJ
cord-290802-761wqgbe	41	28	drug	drug	NN
cord-290802-761wqgbe	41	29	design	design	NN
cord-290802-761wqgbe	41	30	and	and	CC
cord-290802-761wqgbe	41	31	discovery	discovery	NN
cord-290802-761wqgbe	41	32	.	.	.
cord-290802-761wqgbe	42	1	Finally	finally	RB
cord-290802-761wqgbe	42	2	,	,	,
cord-290802-761wqgbe	42	3	combining	combine	VBG
cord-290802-761wqgbe	42	4	the	the	DT
cord-290802-761wqgbe	42	5	new	new	JJ
cord-290802-761wqgbe	42	6	structure	structure	NN
cord-290802-761wqgbe	42	7	-	-	HYPH
cord-290802-761wqgbe	42	8	based	base	VBN
cord-290802-761wqgbe	42	9	insights	insight	NNS
cord-290802-761wqgbe	42	10	and	and	CC
cord-290802-761wqgbe	42	11	a	a	DT
cord-290802-761wqgbe	42	12	virtual	virtual	JJ
cord-290802-761wqgbe	42	13	docking	docking	NN
cord-290802-761wqgbe	42	14	process	process	NN
cord-290802-761wqgbe	42	15	with	with	IN
cord-290802-761wqgbe	42	16	an	an	DT
cord-290802-761wqgbe	42	17	antiviral	antiviral	JJ
cord-290802-761wqgbe	42	18	compound	compound	NN
cord-290802-761wqgbe	42	19	library	library	NN
cord-290802-761wqgbe	42	20	from	from	IN
cord-290802-761wqgbe	42	21	Drugbank	Drugbank	NNP
cord-290802-761wqgbe	42	22	(	(	-LRB-
cord-290802-761wqgbe	42	23	www.drugbank.ca	www.drugbank.ca	NNP
cord-290802-761wqgbe	42	24	)	)	-RRB-
cord-290802-761wqgbe	42	25	,	,	,
cord-290802-761wqgbe	42	26	we	-PRON-	PRP
cord-290802-761wqgbe	42	27	determined	determine	VBD
cord-290802-761wqgbe	42	28	specific	specific	JJ
cord-290802-761wqgbe	42	29	potential	potential	JJ
cord-290802-761wqgbe	42	30	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	42	31	as	as	IN
cord-290802-761wqgbe	42	32	a	a	DT
cord-290802-761wqgbe	42	33	proof	proof	NN
cord-290802-761wqgbe	42	34	of	of	IN
cord-290802-761wqgbe	42	35	concept	concept	NN
cord-290802-761wqgbe	42	36	for	for	IN
cord-290802-761wqgbe	42	37	drug	drug	NN
cord-290802-761wqgbe	42	38	-	-	HYPH
cord-290802-761wqgbe	42	39	repurposing	repurpose	VBG
cord-290802-761wqgbe	42	40	opportunities	opportunity	NNS
cord-290802-761wqgbe	42	41	as	as	RB
cord-290802-761wqgbe	42	42	well	well	RB
cord-290802-761wqgbe	42	43	as	as	IN
cord-290802-761wqgbe	42	44	for	for	IN
cord-290802-761wqgbe	42	45	gaining	gain	VBG
cord-290802-761wqgbe	42	46	new	new	JJ
cord-290802-761wqgbe	42	47	insights	insight	NNS
cord-290802-761wqgbe	42	48	into	into	IN
cord-290802-761wqgbe	42	49	possible	possible	JJ
cord-290802-761wqgbe	42	50	modes	mode	NNS
cord-290802-761wqgbe	42	51	of	of	IN
cord-290802-761wqgbe	42	52	inhibition	inhibition	NN
cord-290802-761wqgbe	42	53	.	.	.
cord-290802-761wqgbe	43	1	We	-PRON-	PRP
cord-290802-761wqgbe	43	2	first	first	RB
cord-290802-761wqgbe	43	3	counted	count	VBD
cord-290802-761wqgbe	43	4	the	the	DT
cord-290802-761wqgbe	43	5	PDB	PDB	NNP
cord-290802-761wqgbe	43	6	IDs	id	NNS
cord-290802-761wqgbe	43	7	of	of	IN
cord-290802-761wqgbe	43	8	all	all	DT
cord-290802-761wqgbe	43	9	RDRP	RDRP	NNP
cord-290802-761wqgbe	43	10	structures	structure	NNS
cord-290802-761wqgbe	43	11	by	by	IN
cord-290802-761wqgbe	43	12	accessing	access	VBG
cord-290802-761wqgbe	43	13	the	the	DT
cord-290802-761wqgbe	43	14	ProRule	ProRule	NNP
cord-290802-761wqgbe	43	15	accession	accession	NN
cord-290802-761wqgbe	43	16	number	number	NN
cord-290802-761wqgbe	43	17	of	of	IN
cord-290802-761wqgbe	43	18	RDRP	RDRP	NNP
cord-290802-761wqgbe	43	19	(	(	-LRB-
cord-290802-761wqgbe	43	20	PRU00539	PRU00539	NNP
cord-290802-761wqgbe	43	21	)	)	-RRB-
cord-290802-761wqgbe	43	22	using	use	VBG
cord-290802-761wqgbe	43	23	the	the	DT
cord-290802-761wqgbe	43	24	PROSITE	PROSITE	NNP
cord-290802-761wqgbe	43	25	21	21	CD
cord-290802-761wqgbe	43	26	(	(	-LRB-
cord-290802-761wqgbe	43	27	Table	Table	NNP
cord-290802-761wqgbe	43	28	S2	S2	NNP
cord-290802-761wqgbe	43	29	)	)	-RRB-
cord-290802-761wqgbe	43	30	.	.	.
cord-290802-761wqgbe	44	1	We	-PRON-	PRP
cord-290802-761wqgbe	44	2	then	then	RB
cord-290802-761wqgbe	44	3	filtered	filter	VBD
cord-290802-761wqgbe	44	4	out	out	RP
cord-290802-761wqgbe	44	5	all	all	DT
cord-290802-761wqgbe	44	6	of	of	IN
cord-290802-761wqgbe	44	7	apo	apo	NNP
cord-290802-761wqgbe	44	8	-	-	HYPH
cord-290802-761wqgbe	44	9	RDRP	RDRP	NNP
cord-290802-761wqgbe	44	10	structures	structure	NNS
cord-290802-761wqgbe	44	11	and	and	CC
cord-290802-761wqgbe	44	12	complexes	complex	NNS
cord-290802-761wqgbe	44	13	with	with	IN
cord-290802-761wqgbe	44	14	invalid	invalid	JJ
cord-290802-761wqgbe	44	15	small	small	JJ
cord-290802-761wqgbe	44	16	molecules	molecule	NNS
cord-290802-761wqgbe	44	17	such	such	JJ
cord-290802-761wqgbe	44	18	as	as	IN
cord-290802-761wqgbe	44	19	buffers	buffer	NNS
cord-290802-761wqgbe	44	20	,	,	,
cord-290802-761wqgbe	44	21	organic	organic	JJ
cord-290802-761wqgbe	44	22	cofactors	cofactor	NNS
cord-290802-761wqgbe	44	23	,	,	,
cord-290802-761wqgbe	44	24	and	and	CC
cord-290802-761wqgbe	44	25	solvent	solvent	NN
cord-290802-761wqgbe	44	26	molecules	molecule	NNS
cord-290802-761wqgbe	44	27	such	such	JJ
cord-290802-761wqgbe	44	28	as	as	IN
cord-290802-761wqgbe	44	29	dimethyl	dimethyl	NN
cord-290802-761wqgbe	44	30	sulfoxide	sulfoxide	NN
cord-290802-761wqgbe	44	31	(	(	-LRB-
cord-290802-761wqgbe	44	32	DMSO	DMSO	NNP
cord-290802-761wqgbe	44	33	)	)	-RRB-
cord-290802-761wqgbe	44	34	,	,	,
cord-290802-761wqgbe	44	35	flavin	flavin	NN
cord-290802-761wqgbe	44	36	adenine	adenine	NN
cord-290802-761wqgbe	44	37	dinucleotide	dinucleotide	NN
cord-290802-761wqgbe	44	38	(	(	-LRB-
cord-290802-761wqgbe	44	39	FAD	fad	NN
cord-290802-761wqgbe	44	40	)	)	-RRB-
cord-290802-761wqgbe	44	41	,	,	,
cord-290802-761wqgbe	44	42	and	and	CC
cord-290802-761wqgbe	44	43	glycerol	glycerol	NN
cord-290802-761wqgbe	44	44	by	by	IN
cord-290802-761wqgbe	44	45	checking	check	VBG
cord-290802-761wqgbe	44	46	the	the	DT
cord-290802-761wqgbe	44	47	"	"	``
cord-290802-761wqgbe	44	48	SITE_DESCRIPTION	SITE_DESCRIPTION	NNP
cord-290802-761wqgbe	44	49	"	"	''
cord-290802-761wqgbe	44	50	keywords	keyword	NNS
cord-290802-761wqgbe	44	51	in	in	IN
cord-290802-761wqgbe	44	52	each	each	DT
cord-290802-761wqgbe	44	53	PDB	PDB	NNP
cord-290802-761wqgbe	44	54	structure	structure	NN
cord-290802-761wqgbe	44	55	.	.	.
cord-290802-761wqgbe	45	1	Furthermore	furthermore	RB
cord-290802-761wqgbe	45	2	,	,	,
cord-290802-761wqgbe	45	3	we	-PRON-	PRP
cord-290802-761wqgbe	45	4	removed	remove	VBD
cord-290802-761wqgbe	45	5	complexes	complex	NNS
cord-290802-761wqgbe	45	6	where	where	WRB
cord-290802-761wqgbe	45	7	the	the	DT
cord-290802-761wqgbe	45	8	ligands	ligand	NNS
cord-290802-761wqgbe	45	9	bind	bind	VBP
cord-290802-761wqgbe	45	10	the	the	DT
cord-290802-761wqgbe	45	11	surface	surface	NN
cord-290802-761wqgbe	45	12	,	,	,
cord-290802-761wqgbe	45	13	or	or	CC
cord-290802-761wqgbe	45	14	other	other	JJ
cord-290802-761wqgbe	45	15	parts	part	NNS
cord-290802-761wqgbe	45	16	of	of	IN
cord-290802-761wqgbe	45	17	the	the	DT
cord-290802-761wqgbe	45	18	RDRP	RDRP	NNP
cord-290802-761wqgbe	45	19	catalytic	catalytic	JJ
cord-290802-761wqgbe	45	20	domain	domain	NN
cord-290802-761wqgbe	45	21	,	,	,
cord-290802-761wqgbe	45	22	rather	rather	RB
cord-290802-761wqgbe	45	23	than	than	IN
cord-290802-761wqgbe	45	24	the	the	DT
cord-290802-761wqgbe	45	25	core	core	NN
cord-290802-761wqgbe	45	26	architecture	architecture	NN
cord-290802-761wqgbe	45	27	.	.	.
cord-290802-761wqgbe	46	1	Our	-PRON-	PRP$
cord-290802-761wqgbe	46	2	final	final	JJ
cord-290802-761wqgbe	46	3	list	list	NN
cord-290802-761wqgbe	46	4	contained	contain	VBD
cord-290802-761wqgbe	46	5	141	141	CD
cord-290802-761wqgbe	46	6	PDB	PDB	NNP
cord-290802-761wqgbe	46	7	structures	structure	NNS
cord-290802-761wqgbe	46	8	of	of	IN
cord-290802-761wqgbe	46	9	ligand	ligand	NN
cord-290802-761wqgbe	46	10	-	-	HYPH
cord-290802-761wqgbe	46	11	bound	bind	VBN
cord-290802-761wqgbe	46	12	complexes	complex	NNS
cord-290802-761wqgbe	46	13	used	use	VBN
cord-290802-761wqgbe	46	14	to	to	TO
cord-290802-761wqgbe	46	15	encode	encode	VB
cord-290802-761wqgbe	46	16	the	the	DT
cord-290802-761wqgbe	46	17	function	function	NN
cord-290802-761wqgbe	46	18	-	-	HYPH
cord-290802-761wqgbe	46	19	site	site	NN
cord-290802-761wqgbe	46	20	interaction	interaction	NN
cord-290802-761wqgbe	46	21	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	46	22	in	in	IN
cord-290802-761wqgbe	46	23	this	this	DT
cord-290802-761wqgbe	46	24	paper	paper	NN
cord-290802-761wqgbe	46	25	.	.	.
cord-290802-761wqgbe	47	1	The	the	DT
cord-290802-761wqgbe	47	2	pairwise	pairwise	JJ
cord-290802-761wqgbe	47	3	similarity	similarity	NN
cord-290802-761wqgbe	47	4	of	of	IN
cord-290802-761wqgbe	47	5	all	all	DT
cord-290802-761wqgbe	47	6	ligands	ligand	NNS
cord-290802-761wqgbe	47	7	was	be	VBD
cord-290802-761wqgbe	47	8	calculated	calculate	VBN
cord-290802-761wqgbe	47	9	using	use	VBG
cord-290802-761wqgbe	47	10	the	the	DT
cord-290802-761wqgbe	47	11	screenmd	screenmd	NN
cord-290802-761wqgbe	47	12	from	from	IN
cord-290802-761wqgbe	47	13	ChemAxon	ChemAxon	NNP
cord-290802-761wqgbe	47	14	.	.	.
cord-290802-761wqgbe	48	1	23	23	CD
cord-290802-761wqgbe	49	1	Each	each	DT
cord-290802-761wqgbe	49	2	ligand	ligand	NN
cord-290802-761wqgbe	49	3	is	be	VBZ
cord-290802-761wqgbe	49	4	described	describe	VBN
cord-290802-761wqgbe	49	5	using	use	VBG
cord-290802-761wqgbe	49	6	the	the	DT
cord-290802-761wqgbe	49	7	molecular	molecular	JJ
cord-290802-761wqgbe	49	8	descriptor	descriptor	NN
cord-290802-761wqgbe	49	9	ECFP	ECFP	NNP
cord-290802-761wqgbe	49	10	with	with	IN
cord-290802-761wqgbe	49	11	a	a	DT
cord-290802-761wqgbe	49	12	fixed	fix	VBN
cord-290802-761wqgbe	49	13	length	length	NN
cord-290802-761wqgbe	49	14	of	of	IN
cord-290802-761wqgbe	49	15	120	120	CD
cord-290802-761wqgbe	49	16	bits	bit	NNS
cord-290802-761wqgbe	49	17	,	,	,
cord-290802-761wqgbe	49	18	and	and	CC
cord-290802-761wqgbe	49	19	then	then	RB
cord-290802-761wqgbe	49	20	the	the	DT
cord-290802-761wqgbe	49	21	pairwise	pairwise	JJ
cord-290802-761wqgbe	49	22	similarity	similarity	NN
cord-290802-761wqgbe	49	23	is	be	VBZ
cord-290802-761wqgbe	49	24	calculated	calculate	VBN
cord-290802-761wqgbe	49	25	using	use	VBG
cord-290802-761wqgbe	49	26	a	a	DT
cord-290802-761wqgbe	49	27	Tanimoto	Tanimoto	NNP
cord-290802-761wqgbe	49	28	coefficient	coefficient	NN
cord-290802-761wqgbe	49	29	.	.	.
cord-290802-761wqgbe	50	1	24−26	24−26	LS
cord-290802-761wqgbe	51	1	In	in	IN
cord-290802-761wqgbe	51	2	the	the	DT
cord-290802-761wqgbe	51	3	paper	paper	NN
cord-290802-761wqgbe	51	4	,	,	,
cord-290802-761wqgbe	51	5	the	the	DT
cord-290802-761wqgbe	51	6	chemical	chemical	JJ
cord-290802-761wqgbe	51	7	structures	structure	NNS
cord-290802-761wqgbe	51	8	are	be	VBP
cord-290802-761wqgbe	51	9	drawn	draw	VBN
cord-290802-761wqgbe	51	10	using	use	VBG
cord-290802-761wqgbe	51	11	Marvinjs	Marvinjs	NNP
cord-290802-761wqgbe	51	12	from	from	IN
cord-290802-761wqgbe	51	13	ChemAxon	ChemAxon	NNP
cord-290802-761wqgbe	51	14	.	.	.
cord-290802-761wqgbe	52	1	27	27	CD
cord-290802-761wqgbe	53	1	The	the	DT
cord-290802-761wqgbe	53	2	Fs	Fs	NNP
cord-290802-761wqgbe	53	3	-	-	HYPH
cord-290802-761wqgbe	53	4	IFP	IFP	NNP
cord-290802-761wqgbe	53	5	represents	represent	VBZ
cord-290802-761wqgbe	53	6	the	the	DT
cord-290802-761wqgbe	53	7	characteristics	characteristic	NNS
cord-290802-761wqgbe	53	8	of	of	IN
cord-290802-761wqgbe	53	9	protein−ligand	protein−ligand	CD
cord-290802-761wqgbe	53	10	interactions	interaction	NNS
cord-290802-761wqgbe	53	11	at	at	IN
cord-290802-761wqgbe	53	12	functional	functional	JJ
cord-290802-761wqgbe	53	13	sites	site	NNS
cord-290802-761wqgbe	53	14	and	and	CC
cord-290802-761wqgbe	53	15	does	do	VBZ
cord-290802-761wqgbe	53	16	so	so	RB
cord-290802-761wqgbe	53	17	on	on	IN
cord-290802-761wqgbe	53	18	a	a	DT
cord-290802-761wqgbe	53	19	proteome	proteome	NN
cord-290802-761wqgbe	53	20	-	-	HYPH
cord-290802-761wqgbe	53	21	wide	wide	JJ
cord-290802-761wqgbe	53	22	scale	scale	NN
cord-290802-761wqgbe	53	23	,	,	,
cord-290802-761wqgbe	53	24	as	as	IN
cord-290802-761wqgbe	53	25	described	describe	VBN
cord-290802-761wqgbe	53	26	previously	previously	RB
cord-290802-761wqgbe	53	27	.	.	.
cord-290802-761wqgbe	54	1	28−31	28−31	CD
cord-290802-761wqgbe	55	1	Briefly	briefly	RB
cord-290802-761wqgbe	55	2	,	,	,
cord-290802-761wqgbe	55	3	the	the	DT
cord-290802-761wqgbe	55	4	Fs	Fs	NNP
cord-290802-761wqgbe	55	5	-	-	HYPH
cord-290802-761wqgbe	55	6	IFP	IFP	NNP
cord-290802-761wqgbe	55	7	method	method	NN
cord-290802-761wqgbe	55	8	combines	combine	VBZ
cord-290802-761wqgbe	55	9	a	a	DT
cord-290802-761wqgbe	55	10	sequence	sequence	NN
cord-290802-761wqgbe	55	11	-	-	HYPH
cord-290802-761wqgbe	55	12	order	order	NN
cord-290802-761wqgbe	55	13	-	-	HYPH
cord-290802-761wqgbe	55	14	independent	independent	JJ
cord-290802-761wqgbe	55	15	structural	structural	JJ
cord-290802-761wqgbe	55	16	binding	binding	NN
cord-290802-761wqgbe	55	17	-	-	HYPH
cord-290802-761wqgbe	55	18	site	site	NN
cord-290802-761wqgbe	55	19	alignment	alignment	NN
cord-290802-761wqgbe	55	20	method	method	NN
cord-290802-761wqgbe	55	21	32−36	32−36	CD
cord-290802-761wqgbe	55	22	with	with	IN
cord-290802-761wqgbe	55	23	the	the	DT
cord-290802-761wqgbe	55	24	protein−ligand	protein−ligand	NNP
cord-290802-761wqgbe	55	25	interaction	interaction	NN
cord-290802-761wqgbe	55	26	fingerprint	fingerprint	NN
cord-290802-761wqgbe	55	27	strategy	strategy	NN
cord-290802-761wqgbe	55	28	37−39	37−39	CD
cord-290802-761wqgbe	55	29	to	to	TO
cord-290802-761wqgbe	55	30	achieve	achieve	VB
cord-290802-761wqgbe	55	31	comparable	comparable	JJ
cord-290802-761wqgbe	55	32	binding	binding	NN
cord-290802-761wqgbe	55	33	features	feature	NNS
cord-290802-761wqgbe	55	34	.	.	.
cord-290802-761wqgbe	56	1	Application	application	NN
cord-290802-761wqgbe	56	2	of	of	IN
cord-290802-761wqgbe	56	3	the	the	DT
cord-290802-761wqgbe	56	4	Fs	Fs	NNP
cord-290802-761wqgbe	56	5	-	-	HYPH
cord-290802-761wqgbe	56	6	IFP	IFP	NNP
cord-290802-761wqgbe	56	7	method	method	NN
cord-290802-761wqgbe	56	8	involves	involve	VBZ
cord-290802-761wqgbe	56	9	three	three	CD
cord-290802-761wqgbe	56	10	steps	step	NNS
cord-290802-761wqgbe	56	11	.	.	.
cord-290802-761wqgbe	57	1	The	the	DT
cord-290802-761wqgbe	57	2	first	first	JJ
cord-290802-761wqgbe	57	3	step	step	NN
cord-290802-761wqgbe	57	4	is	be	VBZ
cord-290802-761wqgbe	57	5	to	to	TO
cord-290802-761wqgbe	57	6	align	align	VB
cord-290802-761wqgbe	57	7	all	all	DT
cord-290802-761wqgbe	57	8	of	of	IN
cord-290802-761wqgbe	57	9	the	the	DT
cord-290802-761wqgbe	57	10	binding	bind	VBG
cord-290802-761wqgbe	57	11	sites	site	NNS
cord-290802-761wqgbe	57	12	.	.	.
cord-290802-761wqgbe	58	1	The	the	DT
cord-290802-761wqgbe	58	2	secondary	secondary	JJ
cord-290802-761wqgbe	58	3	structures	structure	NNS
cord-290802-761wqgbe	58	4	of	of	IN
cord-290802-761wqgbe	58	5	all	all	DT
cord-290802-761wqgbe	58	6	RDRP	rdrp	NN
cord-290802-761wqgbe	58	7	catalytic	catalytic	JJ
cord-290802-761wqgbe	58	8	domains	domain	NNS
cord-290802-761wqgbe	58	9	are	be	VBP
cord-290802-761wqgbe	58	10	aligned	align	VBN
cord-290802-761wqgbe	58	11	against	against	IN
cord-290802-761wqgbe	58	12	the	the	DT
cord-290802-761wqgbe	58	13	SARS	SARS	NNP
cord-290802-761wqgbe	58	14	-	-	HYPH
cord-290802-761wqgbe	58	15	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	58	16	RDRP	RDRP	NNP
cord-290802-761wqgbe	58	17	structure	structure	NN
cord-290802-761wqgbe	58	18	template	template	NN
cord-290802-761wqgbe	58	19	using	use	VBG
cord-290802-761wqgbe	58	20	the	the	DT
cord-290802-761wqgbe	58	21	sequence	sequence	NN
cord-290802-761wqgbe	58	22	-	-	HYPH
cord-290802-761wqgbe	58	23	order	order	NN
cord-290802-761wqgbe	58	24	-	-	HYPH
cord-290802-761wqgbe	58	25	independent	independent	JJ
cord-290802-761wqgbe	58	26	structural	structural	JJ
cord-290802-761wqgbe	58	27	alignment	alignment	NN
cord-290802-761wqgbe	58	28	program	program	NN
cord-290802-761wqgbe	58	29	TM	TM	NNP
cord-290802-761wqgbe	58	30	-	-	HYPH
cord-290802-761wqgbe	58	31	align	align	VB
cord-290802-761wqgbe	58	32	with	with	IN
cord-290802-761wqgbe	58	33	the	the	DT
cord-290802-761wqgbe	58	34	default	default	NN
cord-290802-761wqgbe	58	35	scoring	scoring	NN
cord-290802-761wqgbe	58	36	function	function	NN
cord-290802-761wqgbe	58	37	.	.	.
cord-290802-761wqgbe	59	1	TM	TM	NNP
cord-290802-761wqgbe	59	2	-	-	HYPH
cord-290802-761wqgbe	59	3	align	align	NN
cord-290802-761wqgbe	59	4	results	result	NNS
cord-290802-761wqgbe	59	5	have	have	VBP
cord-290802-761wqgbe	59	6	a	a	DT
cord-290802-761wqgbe	59	7	value	value	NN
cord-290802-761wqgbe	59	8	between	between	IN
cord-290802-761wqgbe	59	9	0	0	CD
cord-290802-761wqgbe	59	10	and	and	CC
cord-290802-761wqgbe	59	11	1	1	CD
cord-290802-761wqgbe	59	12	.	.	.
cord-290802-761wqgbe	60	1	A	a	DT
cord-290802-761wqgbe	60	2	value	value	NN
cord-290802-761wqgbe	61	1	>	>	XX
cord-290802-761wqgbe	61	2	0.3	0.3	CD
cord-290802-761wqgbe	61	3	implies	imply	VBZ
cord-290802-761wqgbe	61	4	a	a	DT
cord-290802-761wqgbe	61	5	similar	similar	JJ
cord-290802-761wqgbe	61	6	fold	fold	NN
cord-290802-761wqgbe	61	7	,	,	,
cord-290802-761wqgbe	61	8	and	and	CC
cord-290802-761wqgbe	61	9	>	>	XX
cord-290802-761wqgbe	61	10	0.5	0.5	CD
cord-290802-761wqgbe	61	11	implies	imply	VBZ
cord-290802-761wqgbe	61	12	the	the	DT
cord-290802-761wqgbe	61	13	same	same	JJ
cord-290802-761wqgbe	61	14	fold	fold	NN
cord-290802-761wqgbe	61	15	.	.	.
cord-290802-761wqgbe	62	1	34	34	CD
cord-290802-761wqgbe	63	1	The	the	DT
cord-290802-761wqgbe	63	2	alignment	alignment	NN
cord-290802-761wqgbe	63	3	of	of	IN
cord-290802-761wqgbe	63	4	the	the	DT
cord-290802-761wqgbe	63	5	binding	bind	VBG
cord-290802-761wqgbe	63	6	sites	site	NNS
cord-290802-761wqgbe	63	7	was	be	VBD
cord-290802-761wqgbe	63	8	performed	perform	VBN
cord-290802-761wqgbe	63	9	using	use	VBG
cord-290802-761wqgbe	63	10	SMAP	SMAP	NNP
cord-290802-761wqgbe	63	11	with	with	IN
cord-290802-761wqgbe	63	12	default	default	NN
cord-290802-761wqgbe	63	13	parameters	parameter	NNS
cord-290802-761wqgbe	63	14	.	.	.
cord-290802-761wqgbe	64	1	32	32	CD
cord-290802-761wqgbe	64	2	,	,	,
cord-290802-761wqgbe	64	3	33	33	CD
cord-290802-761wqgbe	65	1	The	the	DT
cord-290802-761wqgbe	65	2	SARS	SARS	NNP
cord-290802-761wqgbe	65	3	-	-	HYPH
cord-290802-761wqgbe	65	4	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	65	5	RDRP−remdesivir	RDRP−remdesivir	NNS
cord-290802-761wqgbe	65	6	complex	complex	JJ
cord-290802-761wqgbe	65	7	(	(	-LRB-
cord-290802-761wqgbe	65	8	PDB	PDB	NNP
cord-290802-761wqgbe	65	9	7BV2	7bv2	CD
cord-290802-761wqgbe	65	10	)	)	-RRB-
cord-290802-761wqgbe	65	11	was	be	VBD
cord-290802-761wqgbe	65	12	used	use	VBN
cord-290802-761wqgbe	65	13	as	as	IN
cord-290802-761wqgbe	65	14	the	the	DT
cord-290802-761wqgbe	65	15	template	template	NN
cord-290802-761wqgbe	65	16	,	,	,
cord-290802-761wqgbe	65	17	and	and	CC
cord-290802-761wqgbe	65	18	residues	residue	NNS
cord-290802-761wqgbe	65	19	within	within	IN
cord-290802-761wqgbe	65	20	15	15	CD
cord-290802-761wqgbe	65	21	Å	å	NN
cord-290802-761wqgbe	65	22	of	of	IN
cord-290802-761wqgbe	65	23	the	the	DT
cord-290802-761wqgbe	65	24	ligand	ligand	NN
cord-290802-761wqgbe	65	25	defined	define	VBD
cord-290802-761wqgbe	65	26	the	the	DT
cord-290802-761wqgbe	65	27	binding	binding	NN
cord-290802-761wqgbe	65	28	site	site	NN
cord-290802-761wqgbe	65	29	.	.	.
cord-290802-761wqgbe	66	1	40	40	CD
cord-290802-761wqgbe	67	1	The	the	DT
cord-290802-761wqgbe	67	2	second	second	JJ
cord-290802-761wqgbe	67	3	step	step	NN
cord-290802-761wqgbe	67	4	is	be	VBZ
cord-290802-761wqgbe	67	5	to	to	TO
cord-290802-761wqgbe	67	6	determine	determine	VB
cord-290802-761wqgbe	67	7	the	the	DT
cord-290802-761wqgbe	67	8	Fs	Fs	NNP
cord-290802-761wqgbe	67	9	-	-	HYPH
cord-290802-761wqgbe	67	10	IFP	IFP	NNP
cord-290802-761wqgbe	67	11	of	of	IN
cord-290802-761wqgbe	67	12	every	every	DT
cord-290802-761wqgbe	67	13	complex	complex	NN
cord-290802-761wqgbe	67	14	.	.	.
cord-290802-761wqgbe	68	1	Here	here	RB
cord-290802-761wqgbe	68	2	,	,	,
cord-290802-761wqgbe	68	3	the	the	DT
cord-290802-761wqgbe	68	4	interaction	interaction	NN
cord-290802-761wqgbe	68	5	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	68	6	are	be	VBP
cord-290802-761wqgbe	68	7	encoded	encode	VBN
cord-290802-761wqgbe	68	8	using	use	VBG
cord-290802-761wqgbe	68	9	a	a	DT
cord-290802-761wqgbe	68	10	previously	previously	RB
cord-290802-761wqgbe	68	11	described	describe	VBN
cord-290802-761wqgbe	68	12	interaction	interaction	NN
cord-290802-761wqgbe	68	13	fingerprint	fingerprint	NN
cord-290802-761wqgbe	68	14	method	method	NN
cord-290802-761wqgbe	68	15	(	(	-LRB-
cord-290802-761wqgbe	68	16	IChem	IChem	NNP
cord-290802-761wqgbe	68	17	)	)	-RRB-
cord-290802-761wqgbe	68	18	.	.	.
cord-290802-761wqgbe	69	1	41	41	CD
cord-290802-761wqgbe	70	1	In	in	IN
cord-290802-761wqgbe	70	2	the	the	DT
cord-290802-761wqgbe	70	3	third	third	JJ
cord-290802-761wqgbe	70	4	step	step	NN
cord-290802-761wqgbe	70	5	,	,	,
cord-290802-761wqgbe	70	6	the	the	DT
cord-290802-761wqgbe	70	7	comparable	comparable	JJ
cord-290802-761wqgbe	70	8	interaction	interaction	NN
cord-290802-761wqgbe	70	9	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	70	10	of	of	IN
cord-290802-761wqgbe	70	11	each	each	DT
cord-290802-761wqgbe	70	12	complex	complex	NN
cord-290802-761wqgbe	70	13	are	be	VBP
cord-290802-761wqgbe	70	14	clustered	cluster	VBN
cord-290802-761wqgbe	70	15	using	use	VBG
cord-290802-761wqgbe	70	16	the	the	DT
cord-290802-761wqgbe	70	17	k	k	NN
cord-290802-761wqgbe	70	18	-	-	HYPH
cord-290802-761wqgbe	70	19	means	mean	VBZ
cord-290802-761wqgbe	70	20	method	method	NN
cord-290802-761wqgbe	70	21	in	in	IN
cord-290802-761wqgbe	70	22	the	the	DT
cord-290802-761wqgbe	70	23	R	r	NN
cord-290802-761wqgbe	70	24	package	package	NN
cord-290802-761wqgbe	70	25	.	.	.
cord-290802-761wqgbe	71	1	42	42	CD
cord-290802-761wqgbe	71	2	 	 	_SP
cord-290802-761wqgbe	72	1	For	for	IN
cord-290802-761wqgbe	72	2	screening	screening	NN
cord-290802-761wqgbe	72	3	,	,	,
cord-290802-761wqgbe	72	4	7894	7894	CD
cord-290802-761wqgbe	72	5	annotated	annotate	VBN
cord-290802-761wqgbe	72	6	drug	drug	NN
cord-290802-761wqgbe	72	7	molecules	molecule	NNS
cord-290802-761wqgbe	72	8	were	be	VBD
cord-290802-761wqgbe	72	9	downloaded	download	VBN
cord-290802-761wqgbe	72	10	from	from	IN
cord-290802-761wqgbe	72	11	Drugbank	Drugbank	NNP
cord-290802-761wqgbe	72	12	to	to	TO
cord-290802-761wqgbe	72	13	form	form	VB
cord-290802-761wqgbe	72	14	our	-PRON-	PRP$
cord-290802-761wqgbe	72	15	compound	compound	NN
cord-290802-761wqgbe	72	16	library	library	NN
cord-290802-761wqgbe	72	17	.	.	.
cord-290802-761wqgbe	73	1	43	43	CD
cord-290802-761wqgbe	74	1	These	these	DT
cord-290802-761wqgbe	74	2	drugs	drug	NNS
cord-290802-761wqgbe	74	3	were	be	VBD
cord-290802-761wqgbe	74	4	docked	dock	VBN
cord-290802-761wqgbe	74	5	to	to	IN
cord-290802-761wqgbe	74	6	the	the	DT
cord-290802-761wqgbe	74	7	RDRP	RDRP	NNP
cord-290802-761wqgbe	74	8	catalytic	catalytic	JJ
cord-290802-761wqgbe	74	9	domain	domain	NN
cord-290802-761wqgbe	74	10	using	use	VBG
cord-290802-761wqgbe	74	11	the	the	DT
cord-290802-761wqgbe	74	12	docking	docking	NN
cord-290802-761wqgbe	74	13	software	software	NN
cord-290802-761wqgbe	74	14	Surflex	Surflex	NNP
cord-290802-761wqgbe	74	15	44	44	CD
cord-290802-761wqgbe	75	1	v4.103	v4.103	NNP
cord-290802-761wqgbe	75	2	.	.	.
cord-290802-761wqgbe	76	1	Surflex	Surflex	NNP
cord-290802-761wqgbe	76	2	uses	use	VBZ
cord-290802-761wqgbe	76	3	a	a	DT
cord-290802-761wqgbe	76	4	pseudomolecule	pseudomolecule	NN
cord-290802-761wqgbe	76	5	(	(	-LRB-
cord-290802-761wqgbe	76	6	also	also	RB
cord-290802-761wqgbe	76	7	called	call	VBN
cord-290802-761wqgbe	76	8	an	an	DT
cord-290802-761wqgbe	76	9	idealized	idealized	JJ
cord-290802-761wqgbe	76	10	active	active	JJ
cord-290802-761wqgbe	76	11	ligand	ligand	NN
cord-290802-761wqgbe	76	12	or	or	CC
cord-290802-761wqgbe	76	13	protomol	protomol	NN
cord-290802-761wqgbe	76	14	)	)	-RRB-
cord-290802-761wqgbe	76	15	as	as	IN
cord-290802-761wqgbe	76	16	a	a	DT
cord-290802-761wqgbe	76	17	target	target	NN
cord-290802-761wqgbe	76	18	to	to	TO
cord-290802-761wqgbe	76	19	generate	generate	VB
cord-290802-761wqgbe	76	20	the	the	DT
cord-290802-761wqgbe	76	21	putative	putative	JJ
cord-290802-761wqgbe	76	22	poses	pose	NNS
cord-290802-761wqgbe	76	23	of	of	IN
cord-290802-761wqgbe	76	24	ligands	ligand	NNS
cord-290802-761wqgbe	76	25	in	in	IN
cord-290802-761wqgbe	76	26	the	the	DT
cord-290802-761wqgbe	76	27	protein	protein	NN
cord-290802-761wqgbe	76	28	binding	binding	NN
cord-290802-761wqgbe	76	29	site	site	NN
cord-290802-761wqgbe	76	30	.	.	.
cord-290802-761wqgbe	77	1	45	45	CD
cord-290802-761wqgbe	78	1	The	the	DT
cord-290802-761wqgbe	78	2	putative	putative	JJ
cord-290802-761wqgbe	78	3	poses	pose	NNS
cord-290802-761wqgbe	78	4	are	be	VBP
cord-290802-761wqgbe	78	5	scored	score	VBN
cord-290802-761wqgbe	78	6	using	use	VBG
cord-290802-761wqgbe	78	7	a	a	DT
cord-290802-761wqgbe	78	8	Hammerhead	Hammerhead	NNP
cord-290802-761wqgbe	78	9	scoring	scoring	NN
cord-290802-761wqgbe	78	10	function	function	NN
cord-290802-761wqgbe	78	11	.	.	.
cord-290802-761wqgbe	79	1	46	46	CD
cord-290802-761wqgbe	79	2	We	-PRON-	PRP
cord-290802-761wqgbe	79	3	use	use	VBP
cord-290802-761wqgbe	79	4	a	a	DT
cord-290802-761wqgbe	79	5	residue	residue	NN
cord-290802-761wqgbe	79	6	-	-	HYPH
cord-290802-761wqgbe	79	7	based	base	VBN
cord-290802-761wqgbe	79	8	method	method	NN
cord-290802-761wqgbe	79	9	to	to	TO
cord-290802-761wqgbe	79	10	generate	generate	VB
cord-290802-761wqgbe	79	11	the	the	DT
cord-290802-761wqgbe	79	12	protomol	protomol	NN
cord-290802-761wqgbe	79	13	,	,	,
cord-290802-761wqgbe	79	14	i.e.	i.e.	FW
cord-290802-761wqgbe	79	15	,	,	,
cord-290802-761wqgbe	79	16	the	the	DT
cord-290802-761wqgbe	79	17	residues	residue	NNS
cord-290802-761wqgbe	79	18	that	that	WDT
cord-290802-761wqgbe	79	19	border	border	VBP
cord-290802-761wqgbe	79	20	the	the	DT
cord-290802-761wqgbe	79	21	active	active	JJ
cord-290802-761wqgbe	79	22	site	site	NN
cord-290802-761wqgbe	79	23	.	.	.
cord-290802-761wqgbe	80	1	For	for	IN
cord-290802-761wqgbe	80	2	subpocket	subpocket	NNP
cord-290802-761wqgbe	80	3	1	1	CD
cord-290802-761wqgbe	80	4	,	,	,
cord-290802-761wqgbe	80	5	the	the	DT
cord-290802-761wqgbe	80	6	distilled	distil	VBN
cord-290802-761wqgbe	80	7	binding	binding	NN
cord-290802-761wqgbe	80	8	characteristics	characteristic	NNS
cord-290802-761wqgbe	80	9	(	(	-LRB-
cord-290802-761wqgbe	80	10	see	see	VB
cord-290802-761wqgbe	80	11	Results	result	NNS
cord-290802-761wqgbe	80	12	)	)	-RRB-
cord-290802-761wqgbe	80	13	show	show	VBP
cord-290802-761wqgbe	80	14	that	that	IN
cord-290802-761wqgbe	80	15	subpocket	subpocket	NNP
cord-290802-761wqgbe	80	16	1	1	CD
cord-290802-761wqgbe	80	17	is	be	VBZ
cord-290802-761wqgbe	80	18	located	locate	VBN
cord-290802-761wqgbe	80	19	within	within	IN
cord-290802-761wqgbe	80	20	motifs	motif	NNS
cord-290802-761wqgbe	80	21	A−D	A−D	NNP
cord-290802-761wqgbe	80	22	and	and	CC
cord-290802-761wqgbe	80	23	F−G.	F−G.	NNP
cord-290802-761wqgbe	80	24	From	from	IN
cord-290802-761wqgbe	80	25	these	these	DT
cord-290802-761wqgbe	80	26	motifs	motif	NNS
cord-290802-761wqgbe	80	27	,	,	,
cord-290802-761wqgbe	80	28	on	on	IN
cord-290802-761wqgbe	80	29	the	the	DT
cord-290802-761wqgbe	80	30	basis	basis	NN
cord-290802-761wqgbe	80	31	of	of	IN
cord-290802-761wqgbe	80	32	the	the	DT
cord-290802-761wqgbe	80	33	binding	bind	VBG
cord-290802-761wqgbe	80	34	characteristics	characteristic	NNS
cord-290802-761wqgbe	80	35	,	,	,
cord-290802-761wqgbe	80	36	we	-PRON-	PRP
cord-290802-761wqgbe	80	37	chose	choose	VBD
cord-290802-761wqgbe	80	38	residues	residue	NNS
cord-290802-761wqgbe	80	39	N497	N497	NNP
cord-290802-761wqgbe	80	40	,	,	,
cord-290802-761wqgbe	80	41	K551	K551	NNP
cord-290802-761wqgbe	80	42	,	,	,
cord-290802-761wqgbe	80	43	R553	R553	NNPS
cord-290802-761wqgbe	80	44	,	,	,
cord-290802-761wqgbe	80	45	D623	D623	NNS
cord-290802-761wqgbe	80	46	,	,	,
cord-290802-761wqgbe	80	47	S682	S682	NNP
cord-290802-761wqgbe	80	48	,	,	,
cord-290802-761wqgbe	80	49	D760	d760	UH
cord-290802-761wqgbe	80	50	,	,	,
cord-290802-761wqgbe	80	51	and	and	CC
cord-290802-761wqgbe	80	52	F793	F793	NNP
cord-290802-761wqgbe	80	53	as	as	IN
cord-290802-761wqgbe	80	54	bordering	border	VBG
cord-290802-761wqgbe	80	55	the	the	DT
cord-290802-761wqgbe	80	56	active	active	JJ
cord-290802-761wqgbe	80	57	site	site	NN
cord-290802-761wqgbe	80	58	and	and	CC
cord-290802-761wqgbe	80	59	hence	hence	RB
cord-290802-761wqgbe	80	60	to	to	TO
cord-290802-761wqgbe	80	61	generate	generate	VB
cord-290802-761wqgbe	80	62	the	the	DT
cord-290802-761wqgbe	80	63	protomol	protomol	JJ
cord-290802-761wqgbe	80	64	molecule	molecule	NN
cord-290802-761wqgbe	80	65	of	of	IN
cord-290802-761wqgbe	80	66	subpocket	subpocket	NNP
cord-290802-761wqgbe	80	67	1	1	CD
cord-290802-761wqgbe	80	68	.	.	.
cord-290802-761wqgbe	81	1	Similarly	similarly	RB
cord-290802-761wqgbe	81	2	,	,	,
cord-290802-761wqgbe	81	3	subpocket	subpocket	NNP
cord-290802-761wqgbe	81	4	2	2	CD
cord-290802-761wqgbe	81	5	involves	involve	VBZ
cord-290802-761wqgbe	81	6	motif	motif	NN
cord-290802-761wqgbe	81	7	E	e	NN
cord-290802-761wqgbe	81	8	,	,	,
cord-290802-761wqgbe	81	9	helix1	helix1	JJ
cord-290802-761wqgbe	81	10	,	,	,
cord-290802-761wqgbe	81	11	and	and	CC
cord-290802-761wqgbe	81	12	the	the	DT
cord-290802-761wqgbe	81	13	thumb	thumb	NN
cord-290802-761wqgbe	81	14	lobe	lobe	NN
cord-290802-761wqgbe	81	15	(	(	-LRB-
cord-290802-761wqgbe	81	16	see	see	VB
cord-290802-761wqgbe	81	17	Results	result	NNS
cord-290802-761wqgbe	81	18	)	)	-RRB-
cord-290802-761wqgbe	81	19	.	.	.
cord-290802-761wqgbe	82	1	Hence	hence	RB
cord-290802-761wqgbe	82	2	,	,	,
cord-290802-761wqgbe	82	3	we	-PRON-	PRP
cord-290802-761wqgbe	82	4	chose	choose	VBD
cord-290802-761wqgbe	82	5	residues	residue	NNS
cord-290802-761wqgbe	82	6	F594	F594	NNP
cord-290802-761wqgbe	82	7	,	,	,
cord-290802-761wqgbe	82	8	S814	s814	NN
cord-290802-761wqgbe	82	9	,	,	,
cord-290802-761wqgbe	82	10	and	and	CC
cord-290802-761wqgbe	82	11	P830	P830	NNP
cord-290802-761wqgbe	82	12	as	as	IN
cord-290802-761wqgbe	82	13	bordering	border	VBG
cord-290802-761wqgbe	82	14	the	the	DT
cord-290802-761wqgbe	82	15	active	active	JJ
cord-290802-761wqgbe	82	16	site	site	NN
cord-290802-761wqgbe	82	17	and	and	CC
cord-290802-761wqgbe	82	18	from	from	IN
cord-290802-761wqgbe	82	19	which	which	WDT
cord-290802-761wqgbe	82	20	to	to	TO
cord-290802-761wqgbe	82	21	generate	generate	VB
cord-290802-761wqgbe	82	22	a	a	DT
cord-290802-761wqgbe	82	23	protomol	protomol	JJ
cord-290802-761wqgbe	82	24	molecule	molecule	NN
cord-290802-761wqgbe	82	25	.	.	.
cord-290802-761wqgbe	83	1	44	44	CD
cord-290802-761wqgbe	84	1	These	these	DT
cord-290802-761wqgbe	84	2	two	two	CD
cord-290802-761wqgbe	84	3	protomol	protomol	JJ
cord-290802-761wqgbe	84	4	molecules	molecule	NNS
cord-290802-761wqgbe	84	5	that	that	WDT
cord-290802-761wqgbe	84	6	define	define	VBP
cord-290802-761wqgbe	84	7	different	different	JJ
cord-290802-761wqgbe	84	8	subpockets	subpocket	NNS
cord-290802-761wqgbe	84	9	were	be	VBD
cord-290802-761wqgbe	84	10	chosen	choose	VBN
cord-290802-761wqgbe	84	11	to	to	TO
cord-290802-761wqgbe	84	12	screen	screen	VB
cord-290802-761wqgbe	84	13	for	for	IN
cord-290802-761wqgbe	84	14	potential	potential	JJ
cord-290802-761wqgbe	84	15	compounds	compound	NNS
cord-290802-761wqgbe	84	16	using	use	VBG
cord-290802-761wqgbe	84	17	default	default	NN
cord-290802-761wqgbe	84	18	parameters	parameter	NNS
cord-290802-761wqgbe	84	19	and	and	CC
cord-290802-761wqgbe	84	20	the	the	DT
cord-290802-761wqgbe	84	21	scoring	scoring	NN
cord-290802-761wqgbe	84	22	function	function	NN
cord-290802-761wqgbe	84	23	.	.	.
cord-290802-761wqgbe	85	1	All	all	DT
cord-290802-761wqgbe	85	2	docked	dock	VBN
cord-290802-761wqgbe	85	3	small	small	JJ
cord-290802-761wqgbe	85	4	molecules	molecule	NNS
cord-290802-761wqgbe	85	5	with	with	IN
cord-290802-761wqgbe	85	6	different	different	JJ
cord-290802-761wqgbe	85	7	binding	binding	NN
cord-290802-761wqgbe	85	8	conformations	conformation	NNS
cord-290802-761wqgbe	85	9	were	be	VBD
cord-290802-761wqgbe	85	10	sorted	sort	VBN
cord-290802-761wqgbe	85	11	based	base	VBN
cord-290802-761wqgbe	85	12	on	on	IN
cord-290802-761wqgbe	85	13	the	the	DT
cord-290802-761wqgbe	85	14	binding	bind	VBG
cord-290802-761wqgbe	85	15	affinity	affinity	NN
cord-290802-761wqgbe	85	16	score	score	NN
cord-290802-761wqgbe	85	17	.	.	.
cord-290802-761wqgbe	86	1	The	the	DT
cord-290802-761wqgbe	86	2	topfive	topfive	NNP
cord-290802-761wqgbe	86	3	highest	highest	RBS
cord-290802-761wqgbe	86	4	scoring	scoring	NN
cord-290802-761wqgbe	86	5	molecules	molecule	NNS
cord-290802-761wqgbe	86	6	from	from	IN
cord-290802-761wqgbe	86	7	different	different	JJ
cord-290802-761wqgbe	86	8	subpockets	subpocket	NNS
cord-290802-761wqgbe	86	9	were	be	VBD
cord-290802-761wqgbe	86	10	further	further	RB
cord-290802-761wqgbe	86	11	analyzed	analyze	VBN
cord-290802-761wqgbe	86	12	.	.	.
cord-290802-761wqgbe	87	1	(	(	-LRB-
cord-290802-761wqgbe	87	2	Table	Table	NNP
cord-290802-761wqgbe	87	3	S2	S2	NNP
cord-290802-761wqgbe	87	4	)	)	-RRB-
cord-290802-761wqgbe	87	5	.	.	.
cord-290802-761wqgbe	88	1	All	all	DT
cord-290802-761wqgbe	88	2	RDRP	RDRP	NNP
cord-290802-761wqgbe	88	3	catalytic	catalytic	JJ
cord-290802-761wqgbe	88	4	domains	domain	NNS
cord-290802-761wqgbe	88	5	show	show	VBP
cord-290802-761wqgbe	88	6	high	high	JJ
cord-290802-761wqgbe	88	7	similarity	similarity	NN
cord-290802-761wqgbe	88	8	(	(	-LRB-
cord-290802-761wqgbe	88	9	Figure	figure	NN
cord-290802-761wqgbe	88	10	2b	2b	CD
cord-290802-761wqgbe	88	11	)	)	-RRB-
cord-290802-761wqgbe	88	12	based	base	VBN
cord-290802-761wqgbe	88	13	on	on	IN
cord-290802-761wqgbe	88	14	secondary	secondary	JJ
cord-290802-761wqgbe	88	15	structure	structure	NN
cord-290802-761wqgbe	88	16	alignment	alignment	NN
cord-290802-761wqgbe	88	17	(	(	-LRB-
cord-290802-761wqgbe	88	18	see	see	VB
cord-290802-761wqgbe	88	19	Methods	Methods	NNPS
cord-290802-761wqgbe	88	20	)	)	-RRB-
cord-290802-761wqgbe	88	21	.	.	.
cord-290802-761wqgbe	89	1	Specifically	specifically	RB
cord-290802-761wqgbe	89	2	,	,	,
cord-290802-761wqgbe	89	3	in	in	IN
cord-290802-761wqgbe	89	4	the	the	DT
cord-290802-761wqgbe	89	5	"	"	``
cord-290802-761wqgbe	89	6	finger	finger	NN
cord-290802-761wqgbe	89	7	"	"	''
cord-290802-761wqgbe	89	8	and	and	CC
cord-290802-761wqgbe	89	9	"	"	``
cord-290802-761wqgbe	89	10	thumb	thumb	NN
cord-290802-761wqgbe	89	11	"	"	''
cord-290802-761wqgbe	89	12	regions	region	NNS
cord-290802-761wqgbe	89	13	they	-PRON-	PRP
cord-290802-761wqgbe	89	14	have	have	VBP
cord-290802-761wqgbe	89	15	the	the	DT
cord-290802-761wqgbe	89	16	same	same	JJ
cord-290802-761wqgbe	89	17	folding	folding	NN
cord-290802-761wqgbe	89	18	patterns	pattern	NNS
cord-290802-761wqgbe	89	19	(	(	-LRB-
cord-290802-761wqgbe	89	20	helix	helix	NN
cord-290802-761wqgbe	89	21	and	and	CC
cord-290802-761wqgbe	89	22	sheet	sheet	NN
cord-290802-761wqgbe	89	23	)	)	-RRB-
cord-290802-761wqgbe	89	24	across	across	IN
cord-290802-761wqgbe	89	25	all	all	DT
cord-290802-761wqgbe	89	26	viruses	virus	NNS
cord-290802-761wqgbe	89	27	.	.	.
cord-290802-761wqgbe	90	1	Likewise	likewise	RB
cord-290802-761wqgbe	90	2	,	,	,
cord-290802-761wqgbe	90	3	the	the	DT
cord-290802-761wqgbe	90	4	conserved	conserve	VBN
cord-290802-761wqgbe	90	5	core	core	NN
cord-290802-761wqgbe	90	6	architectures	architecture	NNS
cord-290802-761wqgbe	90	7	of	of	IN
cord-290802-761wqgbe	90	8	all	all	DT
cord-290802-761wqgbe	90	9	RDRPs	rdrp	NNS
cord-290802-761wqgbe	90	10	,	,	,
cord-290802-761wqgbe	90	11	such	such	JJ
cord-290802-761wqgbe	90	12	as	as	IN
cord-290802-761wqgbe	90	13	motif	motif	NN
cord-290802-761wqgbe	90	14	C	C	NNP
cord-290802-761wqgbe	90	15	,	,	,
cord-290802-761wqgbe	90	16	are	be	VBP
cord-290802-761wqgbe	90	17	high	high	JJ
cord-290802-761wqgbe	90	18	similar	similar	JJ
cord-290802-761wqgbe	90	19	and	and	CC
cord-290802-761wqgbe	90	20	overlap	overlap	VBP
cord-290802-761wqgbe	90	21	(	(	-LRB-
cord-290802-761wqgbe	90	22	Figure	figure	NN
cord-290802-761wqgbe	90	23	 	 	_SP
cord-290802-761wqgbe	90	24	2b	2b	CD
cord-290802-761wqgbe	90	25	)	)	-RRB-
cord-290802-761wqgbe	90	26	.	.	.
cord-290802-761wqgbe	91	1	The	the	DT
cord-290802-761wqgbe	91	2	global	global	JJ
cord-290802-761wqgbe	91	3	structural	structural	JJ
cord-290802-761wqgbe	91	4	similarity	similarity	NN
cord-290802-761wqgbe	91	5	between	between	IN
cord-290802-761wqgbe	91	6	all	all	DT
cord-290802-761wqgbe	91	7	RDRP	rdrp	NN
cord-290802-761wqgbe	91	8	catalytic	catalytic	JJ
cord-290802-761wqgbe	91	9	domains	domain	NNS
cord-290802-761wqgbe	91	10	and	and	CC
cord-290802-761wqgbe	91	11	the	the	DT
cord-290802-761wqgbe	91	12	SARS	SARS	NNP
cord-290802-761wqgbe	91	13	-	-	HYPH
cord-290802-761wqgbe	91	14	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	91	15	RDRP	RDRP	NNP
cord-290802-761wqgbe	91	16	was	be	VBD
cord-290802-761wqgbe	91	17	calculated	calculate	VBN
cord-290802-761wqgbe	91	18	(	(	-LRB-
cord-290802-761wqgbe	91	19	see	see	VB
cord-290802-761wqgbe	91	20	Methods	Methods	NNPS
cord-290802-761wqgbe	91	21	)	)	-RRB-
cord-290802-761wqgbe	91	22	.	.	.
cord-290802-761wqgbe	92	1	The	the	DT
cord-290802-761wqgbe	92	2	lowest	low	JJS
cord-290802-761wqgbe	92	3	similarity	similarity	NN
cord-290802-761wqgbe	92	4	0.33	0.33	CD
cord-290802-761wqgbe	92	5	,	,	,
cord-290802-761wqgbe	92	6	is	be	VBZ
cord-290802-761wqgbe	92	7	from	from	IN
cord-290802-761wqgbe	92	8	bacteria	bacteria	NNS
cord-290802-761wqgbe	92	9	,	,	,
cord-290802-761wqgbe	92	10	Escherichia	escherichia	NN
cord-290802-761wqgbe	92	11	coli	coli	NNS
cord-290802-761wqgbe	92	12	(	(	-LRB-
cord-290802-761wqgbe	92	13	UniProt	UniProt	NNP
cord-290802-761wqgbe	92	14	P0A6P1	P0A6P1	NNS
cord-290802-761wqgbe	92	15	)	)	-RRB-
cord-290802-761wqgbe	92	16	.	.	.
cord-290802-761wqgbe	93	1	The	the	DT
cord-290802-761wqgbe	93	2	top	top	JJ
cord-290802-761wqgbe	93	3	-	-	HYPH
cord-290802-761wqgbe	93	4	three	three	CD
cord-290802-761wqgbe	93	5	viruses	virus	NNS
cord-290802-761wqgbe	93	6	with	with	IN
cord-290802-761wqgbe	93	7	a	a	DT
cord-290802-761wqgbe	93	8	RDRP	rdrp	NN
cord-290802-761wqgbe	93	9	similarity	similarity	NN
cord-290802-761wqgbe	93	10	above	above	IN
cord-290802-761wqgbe	93	11	0.65	0.65	CD
cord-290802-761wqgbe	93	12	are	be	VBP
cord-290802-761wqgbe	93	13	poliovirus	poliovirus	NN
cord-290802-761wqgbe	93	14	type	type	NN
cord-290802-761wqgbe	93	15	1	1	CD
cord-290802-761wqgbe	93	16	(	(	-LRB-
cord-290802-761wqgbe	93	17	UniProt	UniProt	NNP
cord-290802-761wqgbe	93	18	P03300	P03300	NNP
cord-290802-761wqgbe	93	19	)	)	-RRB-
cord-290802-761wqgbe	93	20	,	,	,
cord-290802-761wqgbe	93	21	hepatitis	hepatitis	NN
cord-290802-761wqgbe	93	22	C	C	NNP
cord-290802-761wqgbe	93	23	virus	virus	NN
cord-290802-761wqgbe	93	24	(	(	-LRB-
cord-290802-761wqgbe	93	25	HCV	HCV	NNP
cord-290802-761wqgbe	93	26	)	)	-RRB-
cord-290802-761wqgbe	93	27	genotype	genotype	NNP
cord-290802-761wqgbe	93	28	2a	2a	CD
cord-290802-761wqgbe	94	1	(	(	-LRB-
cord-290802-761wqgbe	94	2	UniProt	UniProt	NNP
cord-290802-761wqgbe	94	3	Q99IB8	Q99IB8	NNPS
cord-290802-761wqgbe	94	4	)	)	-RRB-
cord-290802-761wqgbe	94	5	,	,	,
cord-290802-761wqgbe	94	6	and	and	CC
cord-290802-761wqgbe	94	7	hepatitis	hepatitis	NNP
cord-290802-761wqgbe	94	8	C	C	NNP
cord-290802-761wqgbe	94	9	virus	virus	NN
cord-290802-761wqgbe	94	10	genotype	genotype	NN
cord-290802-761wqgbe	94	11	1b	1b	CD
cord-290802-761wqgbe	94	12	(	(	-LRB-
cord-290802-761wqgbe	94	13	UniProt	UniProt	NNP
cord-290802-761wqgbe	94	14	P26663	P26663	NNP
cord-290802-761wqgbe	94	15	,	,	,
cord-290802-761wqgbe	94	16	Figure	Figure	NNP
cord-290802-761wqgbe	94	17	S1	S1	NNP
cord-290802-761wqgbe	94	18	)	)	-RRB-
cord-290802-761wqgbe	94	19	.	.	.
cord-290802-761wqgbe	95	1	In	in	IN
cord-290802-761wqgbe	95	2	sum	sum	NN
cord-290802-761wqgbe	95	3	,	,	,
cord-290802-761wqgbe	95	4	structurally	structurally	RB
cord-290802-761wqgbe	95	5	,	,	,
cord-290802-761wqgbe	95	6	SARS	SARS	NNP
cord-290802-761wqgbe	95	7	-	-	HYPH
cord-290802-761wqgbe	95	8	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	95	9	has	have	VBZ
cord-290802-761wqgbe	95	10	high	high	JJ
cord-290802-761wqgbe	95	11	global/	global/	CD
cord-290802-761wqgbe	95	12	core	core	NN
cord-290802-761wqgbe	95	13	structural	structural	JJ
cord-290802-761wqgbe	95	14	similarity	similarity	NN
cord-290802-761wqgbe	95	15	to	to	IN
cord-290802-761wqgbe	95	16	the	the	DT
cord-290802-761wqgbe	95	17	RDRP	RDRP	NNP
cord-290802-761wqgbe	95	18	catalytic	catalytic	JJ
cord-290802-761wqgbe	95	19	domains	domain	NNS
cord-290802-761wqgbe	95	20	of	of	IN
cord-290802-761wqgbe	95	21	all	all	DT
cord-290802-761wqgbe	95	22	other	other	JJ
cord-290802-761wqgbe	95	23	RNA	RNA	NNP
cord-290802-761wqgbe	95	24	viruses	virus	NNS
cord-290802-761wqgbe	95	25	,	,	,
cord-290802-761wqgbe	95	26	which	which	WDT
cord-290802-761wqgbe	95	27	provides	provide	VBZ
cord-290802-761wqgbe	95	28	an	an	DT
cord-290802-761wqgbe	95	29	opportunity	opportunity	NN
cord-290802-761wqgbe	95	30	for	for	IN
cord-290802-761wqgbe	95	31	structure	structure	NN
cord-290802-761wqgbe	95	32	-	-	HYPH
cord-290802-761wqgbe	95	33	based	base	VBN
cord-290802-761wqgbe	95	34	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	95	35	drug	drug	NN
cord-290802-761wqgbe	95	36	design	design	NN
cord-290802-761wqgbe	95	37	and	and	CC
cord-290802-761wqgbe	95	38	repurposing	repurposing	NN
cord-290802-761wqgbe	95	39	,	,	,
cord-290802-761wqgbe	95	40	noting	note	VBG
cord-290802-761wqgbe	95	41	that	that	IN
cord-290802-761wqgbe	95	42	keys	key	NNS
cord-290802-761wqgbe	95	43	differences	difference	NNS
cord-290802-761wqgbe	95	44	lie	lie	VBP
cord-290802-761wqgbe	95	45	in	in	IN
cord-290802-761wqgbe	95	46	the	the	DT
cord-290802-761wqgbe	95	47	subtle	subtle	JJ
cord-290802-761wqgbe	95	48	details	detail	NNS
cord-290802-761wqgbe	95	49	.	.	.
cord-290802-761wqgbe	96	1	Table	table	NN
cord-290802-761wqgbe	96	2	S3	S3	NNP
cord-290802-761wqgbe	96	3	columns	column	NNS
cord-290802-761wqgbe	96	4	1−3	1−3	CD
cord-290802-761wqgbe	96	5	)	)	-RRB-
cord-290802-761wqgbe	96	6	.	.	.
cord-290802-761wqgbe	97	1	The	the	DT
cord-290802-761wqgbe	97	2	141	141	CD
cord-290802-761wqgbe	97	3	ligands	ligand	NNS
cord-290802-761wqgbe	97	4	come	come	VBP
cord-290802-761wqgbe	97	5	from	from	IN
cord-290802-761wqgbe	97	6	105	105	CD
cord-290802-761wqgbe	97	7	different	different	JJ
cord-290802-761wqgbe	97	8	compounds	compound	NNS
cord-290802-761wqgbe	97	9	,	,	,
cord-290802-761wqgbe	97	10	of	of	IN
cord-290802-761wqgbe	97	11	which	which	WDT
cord-290802-761wqgbe	97	12	16	16	CD
cord-290802-761wqgbe	97	13	compounds	compound	NNS
cord-290802-761wqgbe	97	14	occur	occur	VBP
cord-290802-761wqgbe	97	15	more	more	RBR
cord-290802-761wqgbe	97	16	than	than	IN
cord-290802-761wqgbe	97	17	once	once	RB
cord-290802-761wqgbe	97	18	(	(	-LRB-
cord-290802-761wqgbe	97	19	Figure	figure	NN
cord-290802-761wqgbe	97	20	3a	3a	CD
cord-290802-761wqgbe	97	21	)	)	-RRB-
cord-290802-761wqgbe	97	22	.	.	.
cord-290802-761wqgbe	98	1	The	the	DT
cord-290802-761wqgbe	98	2	top	top	JJ
cord-290802-761wqgbe	98	3	-	-	HYPH
cord-290802-761wqgbe	98	4	four	four	CD
cord-290802-761wqgbe	98	5	recurring	recur	VBG
cord-290802-761wqgbe	98	6	compounds	compound	NNS
cord-290802-761wqgbe	98	7	are	be	VBP
cord-290802-761wqgbe	98	8	GTP	GTP	NNP
cord-290802-761wqgbe	98	9	(	(	-LRB-
cord-290802-761wqgbe	98	10	15	15	CD
cord-290802-761wqgbe	98	11	)	)	-RRB-
cord-290802-761wqgbe	98	12	,	,	,
cord-290802-761wqgbe	98	13	UTP(5	utp(5	LS
cord-290802-761wqgbe	98	14	)	)	-RRB-
cord-290802-761wqgbe	98	15	,	,	,
cord-290802-761wqgbe	98	16	CH1(5	CH1(5	NNP
cord-290802-761wqgbe	98	17	)	)	-RRB-
cord-290802-761wqgbe	98	18	,	,	,
cord-290802-761wqgbe	98	19	and	and	CC
cord-290802-761wqgbe	98	20	ATP(5	ATP(5	NNP
cord-290802-761wqgbe	98	21	)	)	-RRB-
cord-290802-761wqgbe	98	22	,	,	,
cord-290802-761wqgbe	98	23	which	which	WDT
cord-290802-761wqgbe	98	24	all	all	DT
cord-290802-761wqgbe	98	25	have	have	VBP
cord-290802-761wqgbe	98	26	the	the	DT
cord-290802-761wqgbe	98	27	same	same	JJ
cord-290802-761wqgbe	98	28	triphosphate	triphosphate	NN
cord-290802-761wqgbe	98	29	fragment	fragment	NN
cord-290802-761wqgbe	98	30	.	.	.
cord-290802-761wqgbe	99	1	However	however	RB
cord-290802-761wqgbe	99	2	,	,	,
cord-290802-761wqgbe	99	3	the	the	DT
cord-290802-761wqgbe	99	4	pairwise	pairwise	JJ
cord-290802-761wqgbe	99	5	similarities	similarity	NNS
cord-290802-761wqgbe	99	6	of	of	IN
cord-290802-761wqgbe	99	7	85	85	CD
cord-290802-761wqgbe	99	8	%	%	NN
cord-290802-761wqgbe	99	9	compounds	compound	NNS
cord-290802-761wqgbe	99	10	are	be	VBP
cord-290802-761wqgbe	99	11	below	below	IN
cord-290802-761wqgbe	99	12	0.25	0.25	CD
cord-290802-761wqgbe	99	13	(	(	-LRB-
cord-290802-761wqgbe	99	14	Figure	figure	NN
cord-290802-761wqgbe	99	15	3b	3b	CD
cord-290802-761wqgbe	99	16	)	)	-RRB-
cord-290802-761wqgbe	99	17	,	,	,
cord-290802-761wqgbe	99	18	which	which	WDT
cord-290802-761wqgbe	99	19	guarantees	guarantee	VBZ
cord-290802-761wqgbe	99	20	ligand	ligand	NN
cord-290802-761wqgbe	99	21	diversity	diversity	NN
cord-290802-761wqgbe	99	22	and	and	CC
cord-290802-761wqgbe	99	23	diverse	diverse	JJ
cord-290802-761wqgbe	99	24	chemotypes	chemotype	NNS
cord-290802-761wqgbe	99	25	.	.	.
cord-290802-761wqgbe	100	1	Using	use	VBG
cord-290802-761wqgbe	100	2	the	the	DT
cord-290802-761wqgbe	100	3	SARS	SARS	NNP
cord-290802-761wqgbe	100	4	-	-	HYPH
cord-290802-761wqgbe	100	5	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	100	6	RDRP	RDRP	NNP
cord-290802-761wqgbe	100	7	binding	binding	NN
cord-290802-761wqgbe	100	8	site	site	NN
cord-290802-761wqgbe	100	9	as	as	IN
cord-290802-761wqgbe	100	10	a	a	DT
cord-290802-761wqgbe	100	11	template	template	NN
cord-290802-761wqgbe	100	12	,	,	,
cord-290802-761wqgbe	100	13	141	141	CD
cord-290802-761wqgbe	100	14	binding	binding	NN
cord-290802-761wqgbe	100	15	sites	site	NNS
cord-290802-761wqgbe	100	16	were	be	VBD
cord-290802-761wqgbe	100	17	aligned	align	VBN
cord-290802-761wqgbe	100	18	using	use	VBG
cord-290802-761wqgbe	100	19	a	a	DT
cord-290802-761wqgbe	100	20	sequence	sequence	NN
cord-290802-761wqgbe	100	21	-	-	HYPH
cord-290802-761wqgbe	100	22	order	order	NN
cord-290802-761wqgbe	100	23	-	-	HYPH
cord-290802-761wqgbe	100	24	independent	independent	JJ
cord-290802-761wqgbe	100	25	pocket	pocket	NN
cord-290802-761wqgbe	100	26	alignment	alignment	NN
cord-290802-761wqgbe	100	27	method	method	NN
cord-290802-761wqgbe	100	28	resulting	result	VBG
cord-290802-761wqgbe	100	29	in	in	IN
cord-290802-761wqgbe	100	30	a	a	DT
cord-290802-761wqgbe	100	31	comparison	comparison	NN
cord-290802-761wqgbe	100	32	matrix	matrix	NN
cord-290802-761wqgbe	100	33	of	of	IN
cord-290802-761wqgbe	100	34	interacting	interact	VBG
cord-290802-761wqgbe	100	35	amino	amino	NN
cord-290802-761wqgbe	100	36	acids	acid	NNS
cord-290802-761wqgbe	100	37	(	(	-LRB-
cord-290802-761wqgbe	100	38	see	see	VB
cord-290802-761wqgbe	100	39	Methods	Methods	NNPS
cord-290802-761wqgbe	100	40	)	)	-RRB-
cord-290802-761wqgbe	100	41	.	.	.
cord-290802-761wqgbe	101	1	Within	within	IN
cord-290802-761wqgbe	101	2	the	the	DT
cord-290802-761wqgbe	101	3	matrix	matrix	NN
cord-290802-761wqgbe	101	4	,	,	,
cord-290802-761wqgbe	101	5	columns	column	NNS
cord-290802-761wqgbe	101	6	of	of	IN
cord-290802-761wqgbe	101	7	amino	amino	JJ
cord-290802-761wqgbe	101	8	acids	acid	NNS
cord-290802-761wqgbe	101	9	without	without	IN
cord-290802-761wqgbe	101	10	any	any	DT
cord-290802-761wqgbe	101	11	encoded	encode	VBN
cord-290802-761wqgbe	101	12	interaction	interaction	NN
cord-290802-761wqgbe	101	13	information	information	NN
cord-290802-761wqgbe	101	14	were	be	VBD
cord-290802-761wqgbe	101	15	removed	remove	VBN
cord-290802-761wqgbe	101	16	.	.	.
cord-290802-761wqgbe	102	1	Thus	thus	RB
cord-290802-761wqgbe	102	2	,	,	,
cord-290802-761wqgbe	102	3	each	each	DT
cord-290802-761wqgbe	102	4	aligned	align	VBN
cord-290802-761wqgbe	102	5	binding	binding	JJ
cord-290802-761wqgbe	102	6	site	site	NN
cord-290802-761wqgbe	102	7	consists	consist	VBZ
cord-290802-761wqgbe	102	8	of	of	IN
cord-290802-761wqgbe	102	9	123	123	CD
cord-290802-761wqgbe	102	10	columns	column	NNS
cord-290802-761wqgbe	102	11	of	of	IN
cord-290802-761wqgbe	102	12	amino	amino	JJ
cord-290802-761wqgbe	102	13	acids	acid	NNS
cord-290802-761wqgbe	102	14	,	,	,
cord-290802-761wqgbe	102	15	i.e.	i.e.	FW
cord-290802-761wqgbe	102	16	,	,	,
cord-290802-761wqgbe	102	17	the	the	DT
cord-290802-761wqgbe	102	18	interaction	interaction	NN
cord-290802-761wqgbe	102	19	fingerprint	fingerprint	NN
cord-290802-761wqgbe	102	20	(	(	-LRB-
cord-290802-761wqgbe	102	21	Table	Table	NNP
cord-290802-761wqgbe	102	22	S3	S3	NNP
cord-290802-761wqgbe	102	23	)	)	-RRB-
cord-290802-761wqgbe	102	24	.	.	.
cord-290802-761wqgbe	103	1	According	accord	VBG
cord-290802-761wqgbe	103	2	to	to	IN
cord-290802-761wqgbe	103	3	the	the	DT
cord-290802-761wqgbe	103	4	similarity	similarity	NN
cord-290802-761wqgbe	103	5	of	of	IN
cord-290802-761wqgbe	103	6	functionsite	functionsite	JJ
cord-290802-761wqgbe	103	7	interaction	interaction	NN
cord-290802-761wqgbe	103	8	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	103	9	over	over	IN
cord-290802-761wqgbe	103	10	all	all	DT
cord-290802-761wqgbe	103	11	complexes	complex	NNS
cord-290802-761wqgbe	103	12	,	,	,
cord-290802-761wqgbe	103	13	it	-PRON-	PRP
cord-290802-761wqgbe	103	14	was	be	VBD
cord-290802-761wqgbe	103	15	possible	possible	JJ
cord-290802-761wqgbe	103	16	to	to	TO
cord-290802-761wqgbe	103	17	divide	divide	VB
cord-290802-761wqgbe	103	18	the	the	DT
cord-290802-761wqgbe	103	19	binding	bind	VBG
cord-290802-761wqgbe	103	20	modes	mode	NNS
cord-290802-761wqgbe	103	21	into	into	IN
cord-290802-761wqgbe	103	22	four	four	CD
cord-290802-761wqgbe	103	23	classes	class	NNS
cord-290802-761wqgbe	103	24	,	,	,
cord-290802-761wqgbe	103	25	where	where	WRB
cord-290802-761wqgbe	103	26	each	each	DT
cord-290802-761wqgbe	103	27	class	class	NN
cord-290802-761wqgbe	103	28	contains	contain	VBZ
cord-290802-761wqgbe	103	29	multiple	multiple	JJ
cord-290802-761wqgbe	103	30	PDB	PDB	NNP
cord-290802-761wqgbe	103	31	structures	structure	NNS
cord-290802-761wqgbe	103	32	from	from	IN
cord-290802-761wqgbe	103	33	different	different	JJ
cord-290802-761wqgbe	103	34	kinds	kind	NNS
cord-290802-761wqgbe	103	35	of	of	IN
cord-290802-761wqgbe	103	36	viruses	virus	NNS
cord-290802-761wqgbe	103	37	(	(	-LRB-
cord-290802-761wqgbe	103	38	Table	table	NN
cord-290802-761wqgbe	103	39	1	1	CD
cord-290802-761wqgbe	103	40	)	)	-RRB-
cord-290802-761wqgbe	103	41	.	.	.
cord-290802-761wqgbe	104	1	Each	each	DT
cord-290802-761wqgbe	104	2	class	class	NN
cord-290802-761wqgbe	104	3	possesses	possess	VBZ
cord-290802-761wqgbe	104	4	distinct	distinct	JJ
cord-290802-761wqgbe	104	5	binding	bind	VBG
cord-290802-761wqgbe	104	6	characteristics	characteristic	NNS
cord-290802-761wqgbe	104	7	(	(	-LRB-
cord-290802-761wqgbe	104	8	Figure	figure	NN
cord-290802-761wqgbe	104	9	4	4	CD
cord-290802-761wqgbe	104	10	)	)	-RRB-
cord-290802-761wqgbe	104	11	.	.	.
cord-290802-761wqgbe	105	1	3.2.1	3.2.1	CD
cord-290802-761wqgbe	105	2	.	.	.
cord-290802-761wqgbe	106	1	Class	class	NN
cord-290802-761wqgbe	106	2	I.	I.	NNP
cord-290802-761wqgbe	106	3	There	there	EX
cord-290802-761wqgbe	106	4	are	be	VBP
cord-290802-761wqgbe	106	5	11	11	CD
cord-290802-761wqgbe	106	6	aligned	align	VBN
cord-290802-761wqgbe	106	7	PDB	PDB	NNP
cord-290802-761wqgbe	106	8	structures	structure	NNS
cord-290802-761wqgbe	106	9	belonging	belong	VBG
cord-290802-761wqgbe	106	10	to	to	IN
cord-290802-761wqgbe	106	11	the	the	DT
cord-290802-761wqgbe	106	12	same	same	JJ
cord-290802-761wqgbe	106	13	Dengue	Dengue	NNP
cord-290802-761wqgbe	106	14	virus	virus	NN
cord-290802-761wqgbe	106	15	(	(	-LRB-
cord-290802-761wqgbe	106	16	UniProt	UniProt	NNP
cord-290802-761wqgbe	106	17	entry	entry	NN
cord-290802-761wqgbe	106	18	:	:	:
cord-290802-761wqgbe	106	19	Q6YMS4	q6yms4	NN
cord-290802-761wqgbe	106	20	)	)	-RRB-
cord-290802-761wqgbe	106	21	in	in	IN
cord-290802-761wqgbe	106	22	this	this	DT
cord-290802-761wqgbe	106	23	class	class	NN
cord-290802-761wqgbe	106	24	(	(	-LRB-
cord-290802-761wqgbe	106	25	Table	table	NN
cord-290802-761wqgbe	106	26	1	1	CD
cord-290802-761wqgbe	106	27	)	)	-RRB-
cord-290802-761wqgbe	106	28	.	.	.
cord-290802-761wqgbe	107	1	The	the	DT
cord-290802-761wqgbe	107	2	aligned	align	VBN
cord-290802-761wqgbe	107	3	binding	bind	VBG
cord-290802-761wqgbe	107	4	sites	site	NNS
cord-290802-761wqgbe	107	5	have	have	VBP
cord-290802-761wqgbe	107	6	almost	almost	RB
cord-290802-761wqgbe	107	7	the	the	DT
cord-290802-761wqgbe	107	8	same	same	JJ
cord-290802-761wqgbe	107	9	binding	binding	NN
cord-290802-761wqgbe	107	10	patterns	pattern	NNS
cord-290802-761wqgbe	107	11	(	(	-LRB-
cord-290802-761wqgbe	107	12	Figure	figure	NN
cord-290802-761wqgbe	107	13	4	4	CD
cord-290802-761wqgbe	107	14	)	)	-RRB-
cord-290802-761wqgbe	107	15	.	.	.
cord-290802-761wqgbe	108	1	Within	within	IN
cord-290802-761wqgbe	108	2	Motifs	Motifs	NNP
cord-290802-761wqgbe	108	3	A−D	A−D	NNP
cord-290802-761wqgbe	108	4	and	and	CC
cord-290802-761wqgbe	108	5	Motifs	Motifs	NNP
cord-290802-761wqgbe	108	6	F	F	NNP
cord-290802-761wqgbe	108	7	and	and	CC
cord-290802-761wqgbe	108	8	G	G	NNP
cord-290802-761wqgbe	109	1	there	there	EX
cord-290802-761wqgbe	109	2	are	be	VBP
cord-290802-761wqgbe	109	3	no	no	DT
cord-290802-761wqgbe	109	4	interaction	interaction	NN
cord-290802-761wqgbe	109	5	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	109	6	;	;	:
cord-290802-761wqgbe	109	7	however	however	RB
cord-290802-761wqgbe	109	8	,	,	,
cord-290802-761wqgbe	109	9	conserved	conserve	VBN
cord-290802-761wqgbe	109	10	interaction	interaction	NN
cord-290802-761wqgbe	109	11	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	109	12	exist	exist	VBP
cord-290802-761wqgbe	109	13	in	in	IN
cord-290802-761wqgbe	109	14	motif	motif	NN
cord-290802-761wqgbe	109	15	E	e	NN
cord-290802-761wqgbe	109	16	,	,	,
cord-290802-761wqgbe	109	17	helix1	helix1	JJ
cord-290802-761wqgbe	109	18	,	,	,
cord-290802-761wqgbe	109	19	and	and	CC
cord-290802-761wqgbe	109	20	the	the	DT
cord-290802-761wqgbe	109	21	thumb	thumb	NN
cord-290802-761wqgbe	109	22	domain	domain	NN
cord-290802-761wqgbe	109	23	,	,	,
cord-290802-761wqgbe	109	24	implying	imply	VBG
cord-290802-761wqgbe	109	25	the	the	DT
cord-290802-761wqgbe	109	26	ligandbinding	ligandbinde	VBG
cord-290802-761wqgbe	109	27	site	site	NN
cord-290802-761wqgbe	109	28	is	be	VBZ
cord-290802-761wqgbe	109	29	located	locate	VBN
cord-290802-761wqgbe	109	30	at	at	IN
cord-290802-761wqgbe	109	31	the	the	DT
cord-290802-761wqgbe	109	32	palm	palm	NN
cord-290802-761wqgbe	109	33	region	region	NN
cord-290802-761wqgbe	109	34	and	and	CC
cord-290802-761wqgbe	109	35	between	between	IN
cord-290802-761wqgbe	109	36	motif	motif	NN
cord-290802-761wqgbe	109	37	E	e	NN
cord-290802-761wqgbe	109	38	and	and	CC
cord-290802-761wqgbe	109	39	the	the	DT
cord-290802-761wqgbe	109	40	thumb	thumb	NN
cord-290802-761wqgbe	109	41	domain	domain	NN
cord-290802-761wqgbe	109	42	(	(	-LRB-
cord-290802-761wqgbe	109	43	Figure	figure	NN
cord-290802-761wqgbe	109	44	5a	5a	CD
cord-290802-761wqgbe	109	45	)	)	-RRB-
cord-290802-761wqgbe	109	46	.	.	.
cord-290802-761wqgbe	110	1	Residues	residue	NNS
cord-290802-761wqgbe	110	2	L511	L511	NNP
cord-290802-761wqgbe	110	3	,	,	,
cord-290802-761wqgbe	110	4	H512	H512	NNP
cord-290802-761wqgbe	110	5	,	,	,
cord-290802-761wqgbe	110	6	and	and	CC
cord-290802-761wqgbe	110	7	L514	L514	NNP
cord-290802-761wqgbe	110	8	of	of	IN
cord-290802-761wqgbe	110	9	helix1	helix1	NN
cord-290802-761wqgbe	110	10	and	and	CC
cord-290802-761wqgbe	110	11	C709	C709	NNP
cord-290802-761wqgbe	110	12	and	and	CC
cord-290802-761wqgbe	110	13	S710	S710	NNS
cord-290802-761wqgbe	110	14	of	of	IN
cord-290802-761wqgbe	110	15	motif	motif	NN
cord-290802-761wqgbe	111	1	E	E	NNS
cord-290802-761wqgbe	111	2	provide	provide	VBP
cord-290802-761wqgbe	111	3	the	the	DT
cord-290802-761wqgbe	111	4	conserved	conserve	VBN
cord-290802-761wqgbe	111	5	interactions	interaction	NNS
cord-290802-761wqgbe	111	6	(	(	-LRB-
cord-290802-761wqgbe	111	7	Figure	figure	NN
cord-290802-761wqgbe	111	8	5a	5a	CD
cord-290802-761wqgbe	111	9	)	)	-RRB-
cord-290802-761wqgbe	111	10	.	.	.
cord-290802-761wqgbe	112	1	In	in	IN
cord-290802-761wqgbe	112	2	the	the	DT
cord-290802-761wqgbe	112	3	thumb	thumb	NN
cord-290802-761wqgbe	112	4	domain	domain	NN
cord-290802-761wqgbe	112	5	,	,	,
cord-290802-761wqgbe	112	6	the	the	DT
cord-290802-761wqgbe	112	7	interaction	interaction	NN
cord-290802-761wqgbe	112	8	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	112	9	of	of	IN
cord-290802-761wqgbe	112	10	all	all	DT
cord-290802-761wqgbe	112	11	complexes	complex	NNS
cord-290802-761wqgbe	112	12	in	in	IN
cord-290802-761wqgbe	112	13	the	the	DT
cord-290802-761wqgbe	112	14	class	class	NN
cord-290802-761wqgbe	112	15	are	be	VBP
cord-290802-761wqgbe	112	16	similar	similar	JJ
cord-290802-761wqgbe	112	17	,	,	,
cord-290802-761wqgbe	112	18	especially	especially	RB
cord-290802-761wqgbe	112	19	in	in	IN
cord-290802-761wqgbe	112	20	the	the	DT
cord-290802-761wqgbe	112	21	columns	column	NNS
cord-290802-761wqgbe	112	22	marked	mark	VBN
cord-290802-761wqgbe	112	23	with	with	IN
cord-290802-761wqgbe	112	24	the	the	DT
cord-290802-761wqgbe	112	25	dashed	dash	VBN
cord-290802-761wqgbe	112	26	rectangle	rectangle	NN
cord-290802-761wqgbe	112	27	,	,	,
cord-290802-761wqgbe	112	28	(	(	-LRB-
cord-290802-761wqgbe	112	29	Figure	figure	NN
cord-290802-761wqgbe	112	30	4	4	CD
cord-290802-761wqgbe	112	31	)	)	-RRB-
cord-290802-761wqgbe	112	32	.	.	.
cord-290802-761wqgbe	113	1	The	the	DT
cord-290802-761wqgbe	113	2	role	role	NN
cord-290802-761wqgbe	113	3	of	of	IN
cord-290802-761wqgbe	113	4	this	this	DT
cord-290802-761wqgbe	113	5	class	class	NN
cord-290802-761wqgbe	113	6	I	-PRON-	PRP
cord-290802-761wqgbe	113	7	binding	bind	VBG
cord-290802-761wqgbe	113	8	pocket	pocket	NN
cord-290802-761wqgbe	113	9	has	have	VBZ
cord-290802-761wqgbe	113	10	been	be	VBN
cord-290802-761wqgbe	113	11	discussed	discuss	VBN
cord-290802-761wqgbe	113	12	by	by	IN
cord-290802-761wqgbe	113	13	other	other	JJ
cord-290802-761wqgbe	113	14	groups	group	NNS
cord-290802-761wqgbe	113	15	previously	previously	RB
cord-290802-761wqgbe	113	16	.	.	.
cord-290802-761wqgbe	114	1	47	47	CD
cord-290802-761wqgbe	115	1	Noble	Noble	NNP
cord-290802-761wqgbe	115	2	et	et	NNP
cord-290802-761wqgbe	115	3	al	al	NNP
cord-290802-761wqgbe	115	4	.	.	.
cord-290802-761wqgbe	116	1	inhibited	inhibited	JJ
cord-290802-761wqgbe	116	2	enzyme	enzyme	NN
cord-290802-761wqgbe	116	3	activity	activity	NN
cord-290802-761wqgbe	116	4	through	through	IN
cord-290802-761wqgbe	116	5	fragment	fragment	NN
cord-290802-761wqgbe	116	6	screening	screen	VBG
cord-290802-761wqgbe	116	7	47	47	CD
cord-290802-761wqgbe	116	8	that	that	WDT
cord-290802-761wqgbe	116	9	identified	identify	VBD
cord-290802-761wqgbe	116	10	this	this	DT
cord-290802-761wqgbe	116	11	binding	bind	VBG
cord-290802-761wqgbe	116	12	pocket	pocket	NN
cord-290802-761wqgbe	116	13	.	.	.
cord-290802-761wqgbe	117	1	As	as	IN
cord-290802-761wqgbe	117	2	part	part	NN
cord-290802-761wqgbe	117	3	of	of	IN
cord-290802-761wqgbe	117	4	their	-PRON-	PRP$
cord-290802-761wqgbe	117	5	study	study	NN
cord-290802-761wqgbe	117	6	,	,	,
cord-290802-761wqgbe	117	7	by	by	IN
cord-290802-761wqgbe	117	8	changing	change	VBG
cord-290802-761wqgbe	117	9	a	a	DT
cord-290802-761wqgbe	117	10	phenyl	phenyl	NN
cord-290802-761wqgbe	117	11	to	to	IN
cord-290802-761wqgbe	117	12	a	a	DT
cord-290802-761wqgbe	117	13	thiophene	thiophene	NN
cord-290802-761wqgbe	117	14	,	,	,
cord-290802-761wqgbe	117	15	a	a	DT
cord-290802-761wqgbe	117	16	higher	high	JJR
cord-290802-761wqgbe	117	17	binding	bind	VBG
cord-290802-761wqgbe	117	18	affinity	affinity	NN
cord-290802-761wqgbe	117	19	was	be	VBD
cord-290802-761wqgbe	117	20	obtained	obtain	VBN
cord-290802-761wqgbe	117	21	,	,	,
cord-290802-761wqgbe	117	22	highlighting	highlight	VBG
cord-290802-761wqgbe	117	23	the	the	DT
cord-290802-761wqgbe	117	24	role	role	NN
cord-290802-761wqgbe	117	25	of	of	IN
cord-290802-761wqgbe	117	26	this	this	DT
cord-290802-761wqgbe	117	27	pocket	pocket	NN
cord-290802-761wqgbe	117	28	in	in	IN
cord-290802-761wqgbe	117	29	subsequent	subsequent	JJ
cord-290802-761wqgbe	117	30	drug	drug	NN
cord-290802-761wqgbe	117	31	design	design	NN
cord-290802-761wqgbe	117	32	.	.	.
cord-290802-761wqgbe	118	1	3.2.2	3.2.2	NNP
cord-290802-761wqgbe	118	2	.	.	.
cord-290802-761wqgbe	119	1	Class	Class	NNP
cord-290802-761wqgbe	119	2	II	II	NNP
cord-290802-761wqgbe	119	3	.	.	.
cord-290802-761wqgbe	120	1	There	there	EX
cord-290802-761wqgbe	120	2	are	be	VBP
cord-290802-761wqgbe	120	3	50	50	CD
cord-290802-761wqgbe	120	4	PDB	PDB	NNP
cord-290802-761wqgbe	120	5	structures	structure	NNS
cord-290802-761wqgbe	120	6	from	from	IN
cord-290802-761wqgbe	120	7	15	15	CD
cord-290802-761wqgbe	120	8	viruses	virus	NNS
cord-290802-761wqgbe	120	9	(	(	-LRB-
cord-290802-761wqgbe	120	10	Table	table	NN
cord-290802-761wqgbe	120	11	1	1	CD
cord-290802-761wqgbe	120	12	)	)	-RRB-
cord-290802-761wqgbe	120	13	in	in	IN
cord-290802-761wqgbe	120	14	this	this	DT
cord-290802-761wqgbe	120	15	class	class	NN
cord-290802-761wqgbe	120	16	(	(	-LRB-
cord-290802-761wqgbe	120	17	Figure	figure	NN
cord-290802-761wqgbe	120	18	4	4	CD
cord-290802-761wqgbe	120	19	)	)	-RRB-
cord-290802-761wqgbe	120	20	.	.	.
cord-290802-761wqgbe	121	1	Class	Class	NNP
cord-290802-761wqgbe	121	2	II	II	NNP
cord-290802-761wqgbe	121	3	interaction	interaction	NN
cord-290802-761wqgbe	121	4	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	121	5	exist	exist	VBP
cord-290802-761wqgbe	121	6	mainly	mainly	RB
cord-290802-761wqgbe	121	7	in	in	IN
cord-290802-761wqgbe	121	8	the	the	DT
cord-290802-761wqgbe	121	9	region	region	NN
cord-290802-761wqgbe	121	10	of	of	IN
cord-290802-761wqgbe	121	11	motifs	motif	NNS
cord-290802-761wqgbe	121	12	A−D	A−D	NNP
cord-290802-761wqgbe	121	13	and	and	CC
cord-290802-761wqgbe	121	14	motifs	motifs	NNP
cord-290802-761wqgbe	121	15	F	F	NNP
cord-290802-761wqgbe	121	16	and	and	CC
cord-290802-761wqgbe	121	17	G	G	NNP
cord-290802-761wqgbe	121	18	,	,	,
cord-290802-761wqgbe	121	19	implying	imply	VBG
cord-290802-761wqgbe	121	20	the	the	DT
cord-290802-761wqgbe	121	21	ligand	ligand	NN
cord-290802-761wqgbe	121	22	is	be	VBZ
cord-290802-761wqgbe	121	23	located	locate	VBN
cord-290802-761wqgbe	121	24	at	at	IN
cord-290802-761wqgbe	121	25	the	the	DT
cord-290802-761wqgbe	121	26	regions	region	NNS
cord-290802-761wqgbe	121	27	of	of	IN
cord-290802-761wqgbe	121	28	the	the	DT
cord-290802-761wqgbe	121	29	"	"	``
cord-290802-761wqgbe	121	30	palm	palm	NN
cord-290802-761wqgbe	121	31	"	"	''
cord-290802-761wqgbe	121	32	and	and	CC
cord-290802-761wqgbe	121	33	"	"	``
cord-290802-761wqgbe	121	34	fingers	finger	NNS
cord-290802-761wqgbe	121	35	"	"	''
cord-290802-761wqgbe	121	36	(	(	-LRB-
cord-290802-761wqgbe	121	37	Figure	figure	NN
cord-290802-761wqgbe	121	38	5b	5b	CD
cord-290802-761wqgbe	121	39	)	)	-RRB-
cord-290802-761wqgbe	121	40	.	.	.
cord-290802-761wqgbe	122	1	Remdesivir	Remdesivir	NNP
cord-290802-761wqgbe	122	2	is	be	VBZ
cord-290802-761wqgbe	122	3	reported	report	VBN
cord-290802-761wqgbe	122	4	to	to	TO
cord-290802-761wqgbe	122	5	bind	bind	VB
cord-290802-761wqgbe	122	6	in	in	IN
cord-290802-761wqgbe	122	7	this	this	DT
cord-290802-761wqgbe	122	8	subpocket	subpocket	NN
cord-290802-761wqgbe	122	9	19	19	CD
cord-290802-761wqgbe	122	10	where	where	WRB
cord-290802-761wqgbe	122	11	K551	k551	CD
cord-290802-761wqgbe	122	12	and	and	CC
cord-290802-761wqgbe	122	13	R553	R553	NNS
cord-290802-761wqgbe	122	14	are	be	VBP
cord-290802-761wqgbe	122	15	located	locate	VBN
cord-290802-761wqgbe	122	16	within	within	IN
cord-290802-761wqgbe	122	17	motif	motif	NN
cord-290802-761wqgbe	122	18	F	F	NNP
cord-290802-761wqgbe	122	19	,	,	,
cord-290802-761wqgbe	122	20	D623	D623	VBZ
cord-290802-761wqgbe	122	21	located	locate	VBN
cord-290802-761wqgbe	122	22	within	within	IN
cord-290802-761wqgbe	122	23	motif	motif	NN
cord-290802-761wqgbe	122	24	A	a	NN
cord-290802-761wqgbe	122	25	,	,	,
cord-290802-761wqgbe	122	26	S682	S682	NNP
cord-290802-761wqgbe	122	27	located	locate	VBN
cord-290802-761wqgbe	122	28	within	within	IN
cord-290802-761wqgbe	122	29	motif	motif	NN
cord-290802-761wqgbe	122	30	B	b	NN
cord-290802-761wqgbe	122	31	,	,	,
cord-290802-761wqgbe	122	32	and	and	CC
cord-290802-761wqgbe	122	33	D760	D760	NNS
cord-290802-761wqgbe	122	34	located	locate	VBN
cord-290802-761wqgbe	122	35	within	within	IN
cord-290802-761wqgbe	122	36	motif	motif	NN
cord-290802-761wqgbe	122	37	C	C	NNP
cord-290802-761wqgbe	122	38	are	be	VBP
cord-290802-761wqgbe	122	39	the	the	DT
cord-290802-761wqgbe	122	40	major	major	JJ
cord-290802-761wqgbe	122	41	contributors	contributor	NNS
cord-290802-761wqgbe	122	42	to	to	IN
cord-290802-761wqgbe	122	43	ligand	ligand	NN
cord-290802-761wqgbe	122	44	binding	binding	NN
cord-290802-761wqgbe	122	45	(	(	-LRB-
cord-290802-761wqgbe	122	46	PDB	PDB	NNP
cord-290802-761wqgbe	122	47	7BV2	7bv2	CD
cord-290802-761wqgbe	122	48	)	)	-RRB-
cord-290802-761wqgbe	122	49	.	.	.
cord-290802-761wqgbe	123	1	While	while	IN
cord-290802-761wqgbe	123	2	these	these	DT
cord-290802-761wqgbe	123	3	amino	amino	NN
cord-290802-761wqgbe	123	4	acids	acid	NNS
cord-290802-761wqgbe	123	5	are	be	VBP
cord-290802-761wqgbe	123	6	conserved	conserve	VBN
cord-290802-761wqgbe	123	7	,	,	,
cord-290802-761wqgbe	123	8	remdesivir	remdesivir	NNP
cord-290802-761wqgbe	123	9	only	only	RB
cord-290802-761wqgbe	123	10	provides	provide	VBZ
cord-290802-761wqgbe	123	11	moderate	moderate	JJ
cord-290802-761wqgbe	123	12	improvement	improvement	NN
cord-290802-761wqgbe	123	13	in	in	IN
cord-290802-761wqgbe	123	14	the	the	DT
cord-290802-761wqgbe	123	15	recovery	recovery	NN
cord-290802-761wqgbe	123	16	time	time	NN
cord-290802-761wqgbe	123	17	of	of	IN
cord-290802-761wqgbe	123	18	patients	patient	NNS
cord-290802-761wqgbe	123	19	with	with	IN
cord-290802-761wqgbe	123	20	severe	severe	JJ
cord-290802-761wqgbe	123	21	symptoms	symptom	NNS
cord-290802-761wqgbe	123	22	of	of	IN
cord-290802-761wqgbe	123	23	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	123	24	.	.	.
cord-290802-761wqgbe	124	1	4	4	LS
cord-290802-761wqgbe	125	1	Further	further	RB
cord-290802-761wqgbe	125	2	exploring	explore	VBG
cord-290802-761wqgbe	125	3	this	this	DT
cord-290802-761wqgbe	125	4	binding	binding	JJ
cord-290802-761wqgbe	125	5	site	site	NN
cord-290802-761wqgbe	125	6	with	with	IN
cord-290802-761wqgbe	125	7	compounds	compound	NNS
cord-290802-761wqgbe	125	8	of	of	IN
cord-290802-761wqgbe	125	9	a	a	DT
cord-290802-761wqgbe	125	10	higher	high	JJR
cord-290802-761wqgbe	125	11	binding	bind	VBG
cord-290802-761wqgbe	125	12	affinity	affinity	NN
cord-290802-761wqgbe	125	13	would	would	MD
cord-290802-761wqgbe	125	14	seem	seem	VB
cord-290802-761wqgbe	125	15	warranted	warrant	VBN
cord-290802-761wqgbe	125	16	.	.	.
cord-290802-761wqgbe	126	1	3.2.3	3.2.3	CD
cord-290802-761wqgbe	126	2	.	.	.
cord-290802-761wqgbe	127	1	Class	class	NN
cord-290802-761wqgbe	127	2	III	III	NNP
cord-290802-761wqgbe	127	3	.	.	.
cord-290802-761wqgbe	128	1	There	there	EX
cord-290802-761wqgbe	128	2	are	be	VBP
cord-290802-761wqgbe	128	3	17	17	CD
cord-290802-761wqgbe	128	4	PDB	PDB	NNP
cord-290802-761wqgbe	128	5	structures	structure	NNS
cord-290802-761wqgbe	128	6	belonging	belong	VBG
cord-290802-761wqgbe	128	7	to	to	IN
cord-290802-761wqgbe	128	8	three	three	CD
cord-290802-761wqgbe	128	9	RNA	RNA	NNP
cord-290802-761wqgbe	128	10	viruses	virus	NNS
cord-290802-761wqgbe	128	11	(	(	-LRB-
cord-290802-761wqgbe	128	12	Table	table	NN
cord-290802-761wqgbe	128	13	1	1	CD
cord-290802-761wqgbe	128	14	)	)	-RRB-
cord-290802-761wqgbe	128	15	in	in	IN
cord-290802-761wqgbe	128	16	this	this	DT
cord-290802-761wqgbe	128	17	class	class	NN
cord-290802-761wqgbe	128	18	.	.	.
cord-290802-761wqgbe	129	1	The	the	DT
cord-290802-761wqgbe	129	2	interaction	interaction	NN
cord-290802-761wqgbe	129	3	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	129	4	are	be	VBP
cord-290802-761wqgbe	129	5	distributed	distribute	VBN
cord-290802-761wqgbe	129	6	in	in	IN
cord-290802-761wqgbe	129	7	the	the	DT
cord-290802-761wqgbe	129	8	regions	region	NNS
cord-290802-761wqgbe	129	9	helix1	helix1	JJ
cord-290802-761wqgbe	129	10	,	,	,
cord-290802-761wqgbe	129	11	motif	motif	NN
cord-290802-761wqgbe	129	12	C	c	NN
cord-290802-761wqgbe	129	13	,	,	,
cord-290802-761wqgbe	129	14	motif	motif	NN
cord-290802-761wqgbe	129	15	E	e	NN
cord-290802-761wqgbe	129	16	,	,	,
cord-290802-761wqgbe	129	17	and	and	CC
cord-290802-761wqgbe	129	18	the	the	DT
cord-290802-761wqgbe	129	19	thumb	thumb	NN
cord-290802-761wqgbe	129	20	(	(	-LRB-
cord-290802-761wqgbe	129	21	Figure	figure	NN
cord-290802-761wqgbe	129	22	4	4	CD
cord-290802-761wqgbe	129	23	)	)	-RRB-
cord-290802-761wqgbe	129	24	,	,	,
cord-290802-761wqgbe	129	25	which	which	WDT
cord-290802-761wqgbe	129	26	form	form	VBP
cord-290802-761wqgbe	129	27	a	a	DT
cord-290802-761wqgbe	129	28	binding	bind	VBG
cord-290802-761wqgbe	129	29	pocket	pocket	NN
cord-290802-761wqgbe	129	30	to	to	TO
cord-290802-761wqgbe	129	31	accommodate	accommodate	VB
cord-290802-761wqgbe	129	32	the	the	DT
cord-290802-761wqgbe	129	33	ligand	ligand	NN
cord-290802-761wqgbe	129	34	(	(	-LRB-
cord-290802-761wqgbe	129	35	Figure	figure	NN
cord-290802-761wqgbe	129	36	5c	5c	CD
cord-290802-761wqgbe	129	37	)	)	-RRB-
cord-290802-761wqgbe	129	38	.	.	.
cord-290802-761wqgbe	130	1	Specifically	specifically	RB
cord-290802-761wqgbe	130	2	,	,	,
cord-290802-761wqgbe	130	3	in	in	IN
cord-290802-761wqgbe	130	4	helix1	helix1	NN
cord-290802-761wqgbe	130	5	,	,	,
cord-290802-761wqgbe	130	6	the	the	DT
cord-290802-761wqgbe	130	7	three	three	CD
cord-290802-761wqgbe	130	8	residues	residue	NNS
cord-290802-761wqgbe	130	9	P197	P197	NNP
cord-290802-761wqgbe	130	10	,	,	,
cord-290802-761wqgbe	130	11	R200	R200	NNP
cord-290802-761wqgbe	130	12	,	,	,
cord-290802-761wqgbe	130	13	and	and	CC
cord-290802-761wqgbe	130	14	L204	l204	UH
cord-290802-761wqgbe	130	15	provide	provide	VB
cord-290802-761wqgbe	130	16	the	the	DT
cord-290802-761wqgbe	130	17	primary	primary	JJ
cord-290802-761wqgbe	130	18	interactions	interaction	NNS
cord-290802-761wqgbe	130	19	with	with	IN
cord-290802-761wqgbe	130	20	the	the	DT
cord-290802-761wqgbe	130	21	ligand	ligand	NN
cord-290802-761wqgbe	130	22	and	and	CC
cord-290802-761wqgbe	130	23	are	be	VBP
cord-290802-761wqgbe	130	24	conserved	conserve	VBN
cord-290802-761wqgbe	130	25	in	in	IN
cord-290802-761wqgbe	130	26	the	the	DT
cord-290802-761wqgbe	130	27	class	class	NN
cord-290802-761wqgbe	130	28	(	(	-LRB-
cord-290802-761wqgbe	130	29	Figure	figure	NN
cord-290802-761wqgbe	130	30	4	4	CD
cord-290802-761wqgbe	130	31	)	)	-RRB-
cord-290802-761wqgbe	130	32	.	.	.
cord-290802-761wqgbe	131	1	Motif	Motif	NNP
cord-290802-761wqgbe	131	2	C	C	NNP
cord-290802-761wqgbe	131	3	is	be	VBZ
cord-290802-761wqgbe	131	4	a	a	DT
cord-290802-761wqgbe	131	5	beta	beta	NN
cord-290802-761wqgbe	131	6	-	-	HYPH
cord-290802-761wqgbe	131	7	hairpin	hairpin	NN
cord-290802-761wqgbe	131	8	folding	folding	NN
cord-290802-761wqgbe	131	9	(	(	-LRB-
cord-290802-761wqgbe	131	10	Figure	figure	NN
cord-290802-761wqgbe	131	11	1	1	CD
cord-290802-761wqgbe	131	12	)	)	-RRB-
cord-290802-761wqgbe	131	13	,	,	,
cord-290802-761wqgbe	131	14	and	and	CC
cord-290802-761wqgbe	131	15	on	on	IN
cord-290802-761wqgbe	131	16	each	each	DT
cord-290802-761wqgbe	131	17	strand	strand	NN
cord-290802-761wqgbe	131	18	,	,	,
cord-290802-761wqgbe	131	19	there	there	EX
cord-290802-761wqgbe	131	20	are	be	VBP
cord-290802-761wqgbe	131	21	3	3	CD
cord-290802-761wqgbe	131	22	conserved	conserve	VBN
cord-290802-761wqgbe	131	23	amino	amino	NN
cord-290802-761wqgbe	131	24	acids	acid	NNS
cord-290802-761wqgbe	131	25	(	(	-LRB-
cord-290802-761wqgbe	131	26	residues	residue	NNS
cord-290802-761wqgbe	131	27	314−	314−	CD
cord-290802-761wqgbe	131	28	(	(	-LRB-
cord-290802-761wqgbe	131	29	Figures	figure	NNS
cord-290802-761wqgbe	131	30	4	4	CD
cord-290802-761wqgbe	131	31	and	and	CC
cord-290802-761wqgbe	131	32	5c	5c	CD
cord-290802-761wqgbe	131	33	)	)	-RRB-
cord-290802-761wqgbe	131	34	.	.	.
cord-290802-761wqgbe	132	1	Within	within	IN
cord-290802-761wqgbe	132	2	motif	motif	NN
cord-290802-761wqgbe	132	3	E	e	NN
cord-290802-761wqgbe	132	4	,	,	,
cord-290802-761wqgbe	132	5	L360	l360	CC
cord-290802-761wqgbe	132	6	,	,	,
cord-290802-761wqgbe	132	7	I363	I363	NNPS
cord-290802-761wqgbe	132	8	,	,	,
cord-290802-761wqgbe	132	9	S365	S365	NNPS
cord-290802-761wqgbe	132	10	,	,	,
cord-290802-761wqgbe	132	11	C366	C366	NNS
cord-290802-761wqgbe	132	12	,	,	,
cord-290802-761wqgbe	132	13	and	and	CC
cord-290802-761wqgbe	132	14	S368	S368	NNS
cord-290802-761wqgbe	132	15	provide	provide	VBP
cord-290802-761wqgbe	132	16	the	the	DT
cord-290802-761wqgbe	132	17	main	main	JJ
cord-290802-761wqgbe	132	18	binding	binding	NN
cord-290802-761wqgbe	132	19	interactions	interaction	NNS
cord-290802-761wqgbe	132	20	(	(	-LRB-
cord-290802-761wqgbe	132	21	Figure	figure	NN
cord-290802-761wqgbe	132	22	5c	5c	CD
cord-290802-761wqgbe	132	23	)	)	-RRB-
cord-290802-761wqgbe	132	24	.	.	.
cord-290802-761wqgbe	133	1	Two	two	CD
cord-290802-761wqgbe	133	2	conserved	conserved	JJ
cord-290802-761wqgbe	133	3	residues	residue	NNS
cord-290802-761wqgbe	133	4	(	(	-LRB-
cord-290802-761wqgbe	133	5	L360	L360	NNS
cord-290802-761wqgbe	133	6	and	and	CC
cord-290802-761wqgbe	133	7	I363	I363	NNPS
cord-290802-761wqgbe	133	8	)	)	-RRB-
cord-290802-761wqgbe	133	9	define	define	VB
cord-290802-761wqgbe	133	10	a	a	DT
cord-290802-761wqgbe	133	11	unique	unique	JJ
cord-290802-761wqgbe	133	12	fingerprint	fingerprint	NN
cord-290802-761wqgbe	133	13	for	for	IN
cord-290802-761wqgbe	133	14	the	the	DT
cord-290802-761wqgbe	133	15	class	class	NN
cord-290802-761wqgbe	133	16	.	.	.
cord-290802-761wqgbe	134	1	Compared	compare	VBN
cord-290802-761wqgbe	134	2	with	with	IN
cord-290802-761wqgbe	134	3	the	the	DT
cord-290802-761wqgbe	134	4	class	class	NN
cord-290802-761wqgbe	134	5	I	-PRON-	PRP
cord-290802-761wqgbe	134	6	binding	bind	VBG
cord-290802-761wqgbe	134	7	pocket	pocket	NN
cord-290802-761wqgbe	134	8	,	,	,
cord-290802-761wqgbe	134	9	both	both	DT
cord-290802-761wqgbe	134	10	pockets	pocket	NNS
cord-290802-761wqgbe	134	11	are	be	VBP
cord-290802-761wqgbe	134	12	composed	compose	VBN
cord-290802-761wqgbe	134	13	of	of	IN
cord-290802-761wqgbe	134	14	helix1	helix1	NN
cord-290802-761wqgbe	134	15	,	,	,
cord-290802-761wqgbe	134	16	motif	motif	NN
cord-290802-761wqgbe	134	17	E	e	NN
cord-290802-761wqgbe	134	18	,	,	,
cord-290802-761wqgbe	134	19	and	and	CC
cord-290802-761wqgbe	134	20	the	the	DT
cord-290802-761wqgbe	134	21	thumb	thumb	NN
cord-290802-761wqgbe	134	22	domain	domain	NN
cord-290802-761wqgbe	134	23	.	.	.
cord-290802-761wqgbe	135	1	However	however	RB
cord-290802-761wqgbe	135	2	,	,	,
cord-290802-761wqgbe	135	3	the	the	DT
cord-290802-761wqgbe	135	4	difference	difference	NN
cord-290802-761wqgbe	135	5	is	be	VBZ
cord-290802-761wqgbe	135	6	that	that	IN
cord-290802-761wqgbe	135	7	in	in	IN
cord-290802-761wqgbe	135	8	class	class	NN
cord-290802-761wqgbe	135	9	III	III	NNP
cord-290802-761wqgbe	135	10	,	,	,
cord-290802-761wqgbe	135	11	motif	motif	NN
cord-290802-761wqgbe	135	12	C	c	NN
cord-290802-761wqgbe	135	13	is	be	VBZ
cord-290802-761wqgbe	135	14	involved	involve	VBN
cord-290802-761wqgbe	135	15	as	as	RB
cord-290802-761wqgbe	135	16	well	well	RB
cord-290802-761wqgbe	135	17	;	;	:
cord-290802-761wqgbe	135	18	thus	thus	RB
cord-290802-761wqgbe	135	19	,	,	,
cord-290802-761wqgbe	135	20	the	the	DT
cord-290802-761wqgbe	135	21	binding	bind	VBG
cord-290802-761wqgbe	135	22	pockets	pocket	NNS
cord-290802-761wqgbe	135	23	partially	partially	RB
cord-290802-761wqgbe	135	24	overlap	overlap	VBP
cord-290802-761wqgbe	135	25	each	each	DT
cord-290802-761wqgbe	135	26	other	other	JJ
cord-290802-761wqgbe	135	27	.	.	.
cord-290802-761wqgbe	136	1	In	in	IN
cord-290802-761wqgbe	136	2	a	a	DT
cord-290802-761wqgbe	136	3	previous	previous	JJ
cord-290802-761wqgbe	136	4	report	report	NN
cord-290802-761wqgbe	136	5	,	,	,
cord-290802-761wqgbe	136	6	48	48	CD
cord-290802-761wqgbe	136	7	Mayland	Mayland	NNP
cord-290802-761wqgbe	136	8	et	et	NNP
cord-290802-761wqgbe	136	9	al	al	NNP
cord-290802-761wqgbe	136	10	.	.	NNP
cord-290802-761wqgbe	136	11	discovered	discover	VBD
cord-290802-761wqgbe	136	12	an	an	DT
cord-290802-761wqgbe	136	13	inhibitor	inhibitor	NN
cord-290802-761wqgbe	136	14	GSK-5852	gsk-5852	NN
cord-290802-761wqgbe	136	15	,	,	,
cord-290802-761wqgbe	136	16	which	which	WDT
cord-290802-761wqgbe	136	17	just	just	RB
cord-290802-761wqgbe	136	18	targets	target	VBZ
cord-290802-761wqgbe	136	19	the	the	DT
cord-290802-761wqgbe	136	20	class	class	NN
cord-290802-761wqgbe	136	21	III	iii	CD
cord-290802-761wqgbe	136	22	pocket	pocket	NN
cord-290802-761wqgbe	136	23	in	in	IN
cord-290802-761wqgbe	136	24	HCV	HCV	NNP
cord-290802-761wqgbe	136	25	RDRP	RDRP	NNP
cord-290802-761wqgbe	136	26	,	,	,
cord-290802-761wqgbe	136	27	to	to	TO
cord-290802-761wqgbe	136	28	treat	treat	VB
cord-290802-761wqgbe	136	29	HCV	HCV	NNP
cord-290802-761wqgbe	136	30	infection	infection	NN
cord-290802-761wqgbe	136	31	.	.	.
cord-290802-761wqgbe	137	1	48	48	CD
cord-290802-761wqgbe	137	2	3.2.4	3.2.4	CD
cord-290802-761wqgbe	137	3	.	.	.
cord-290802-761wqgbe	138	1	Class	Class	NNP
cord-290802-761wqgbe	138	2	IV	IV	NNP
cord-290802-761wqgbe	138	3	.	.	.
cord-290802-761wqgbe	139	1	This	this	DT
cord-290802-761wqgbe	139	2	is	be	VBZ
cord-290802-761wqgbe	139	3	the	the	DT
cord-290802-761wqgbe	139	4	largest	large	JJS
cord-290802-761wqgbe	139	5	class	class	NN
cord-290802-761wqgbe	139	6	with	with	IN
cord-290802-761wqgbe	139	7	63	63	CD
cord-290802-761wqgbe	139	8	PDB	PDB	NNP
cord-290802-761wqgbe	139	9	structures	structure	NNS
cord-290802-761wqgbe	139	10	belonging	belong	VBG
cord-290802-761wqgbe	139	11	to	to	IN
cord-290802-761wqgbe	139	12	4	4	CD
cord-290802-761wqgbe	139	13	viruses	virus	NNS
cord-290802-761wqgbe	139	14	(	(	-LRB-
cord-290802-761wqgbe	139	15	Table	table	NN
cord-290802-761wqgbe	139	16	1	1	CD
cord-290802-761wqgbe	139	17	)	)	-RRB-
cord-290802-761wqgbe	139	18	and	and	CC
cord-290802-761wqgbe	139	19	has	have	VBZ
cord-290802-761wqgbe	139	20	interaction	interaction	NN
cord-290802-761wqgbe	139	21	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	139	22	most	most	RBS
cord-290802-761wqgbe	139	23	similar	similar	JJ
cord-290802-761wqgbe	139	24	to	to	IN
cord-290802-761wqgbe	139	25	class	class	NN
cord-290802-761wqgbe	139	26	I	i	NN
cord-290802-761wqgbe	139	27	and	and	CC
cord-290802-761wqgbe	139	28	class	class	NN
cord-290802-761wqgbe	139	29	III	iii	CD
cord-290802-761wqgbe	139	30	(	(	-LRB-
cord-290802-761wqgbe	139	31	Figure	figure	NN
cord-290802-761wqgbe	139	32	4	4	CD
cord-290802-761wqgbe	139	33	)	)	-RRB-
cord-290802-761wqgbe	139	34	.	.	.
cord-290802-761wqgbe	140	1	Specifically	specifically	RB
cord-290802-761wqgbe	140	2	,	,	,
cord-290802-761wqgbe	140	3	using	use	VBG
cord-290802-761wqgbe	140	4	a	a	DT
cord-290802-761wqgbe	140	5	HCV	HCV	NNP
cord-290802-761wqgbe	140	6	complex	complex	NN
cord-290802-761wqgbe	140	7	(	(	-LRB-
cord-290802-761wqgbe	140	8	PDB	PDB	NNP
cord-290802-761wqgbe	140	9	ID	ID	NNP
cord-290802-761wqgbe	140	10	3cwj	3cwj	CD
cord-290802-761wqgbe	140	11	)	)	-RRB-
cord-290802-761wqgbe	140	12	as	as	IN
cord-290802-761wqgbe	140	13	the	the	DT
cord-290802-761wqgbe	140	14	representative	representative	NN
cord-290802-761wqgbe	140	15	(	(	-LRB-
cord-290802-761wqgbe	140	16	Figure	Figure	NNP
cord-290802-761wqgbe	140	17	5d	5d	CD
cord-290802-761wqgbe	140	18	)	)	-RRB-
cord-290802-761wqgbe	140	19	,	,	,
cord-290802-761wqgbe	140	20	in	in	IN
cord-290802-761wqgbe	140	21	the	the	DT
cord-290802-761wqgbe	140	22	region	region	NN
cord-290802-761wqgbe	140	23	of	of	IN
cord-290802-761wqgbe	140	24	helix1	helix1	NN
cord-290802-761wqgbe	140	25	,	,	,
cord-290802-761wqgbe	140	26	F193	F193	NNP
cord-290802-761wqgbe	140	27	,	,	,
cord-290802-761wqgbe	140	28	P197	P197	NNP
cord-290802-761wqgbe	140	29	,	,	,
cord-290802-761wqgbe	140	30	and	and	CC
cord-290802-761wqgbe	140	31	R200	R200	NNP
cord-290802-761wqgbe	140	32	interact	interact	VB
cord-290802-761wqgbe	140	33	with	with	IN
cord-290802-761wqgbe	140	34	the	the	DT
cord-290802-761wqgbe	140	35	ligand	ligand	NN
cord-290802-761wqgbe	140	36	.	.	.
cord-290802-761wqgbe	141	1	Residues	Residues	NNP
cord-290802-761wqgbe	141	2	D318	d318	POS
cord-290802-761wqgbe	141	3	and	and	CC
cord-290802-761wqgbe	141	4	D319	D319	NNPS
cord-290802-761wqgbe	141	5	from	from	IN
cord-290802-761wqgbe	141	6	motif	motif	NN
cord-290802-761wqgbe	141	7	C	c	NN
cord-290802-761wqgbe	141	8	and	and	CC
cord-290802-761wqgbe	141	9	residue	residue	NN
cord-290802-761wqgbe	141	10	C366	C366	NNS
cord-290802-761wqgbe	141	11	from	from	IN
cord-290802-761wqgbe	141	12	motif	motif	NN
cord-290802-761wqgbe	141	13	E	e	NN
cord-290802-761wqgbe	141	14	are	be	VBP
cord-290802-761wqgbe	141	15	also	also	RB
cord-290802-761wqgbe	141	16	conserved	conserve	VBN
cord-290802-761wqgbe	141	17	,	,	,
cord-290802-761wqgbe	141	18	as	as	IN
cord-290802-761wqgbe	141	19	was	be	VBD
cord-290802-761wqgbe	141	20	found	find	VBN
cord-290802-761wqgbe	141	21	in	in	IN
cord-290802-761wqgbe	141	22	class	class	NN
cord-290802-761wqgbe	141	23	III	III	NNP
cord-290802-761wqgbe	141	24	.	.	.
cord-290802-761wqgbe	142	1	Distinct	distinct	JJ
cord-290802-761wqgbe	142	2	from	from	IN
cord-290802-761wqgbe	142	3	classes	class	NNS
cord-290802-761wqgbe	143	1	I	-PRON-	PRP
cord-290802-761wqgbe	143	2	and	and	CC
cord-290802-761wqgbe	143	3	III	III	NNP
cord-290802-761wqgbe	143	4	,	,	,
cord-290802-761wqgbe	143	5	residues	residue	NNS
cord-290802-761wqgbe	143	6	from	from	IN
cord-290802-761wqgbe	143	7	motif	motif	NN
cord-290802-761wqgbe	143	8	B	B	NNP
cord-290802-761wqgbe	143	9	participate	participate	VB
cord-290802-761wqgbe	143	10	in	in	IN
cord-290802-761wqgbe	143	11	the	the	DT
cord-290802-761wqgbe	143	12	binding	bind	VBG
cord-290802-761wqgbe	143	13	interactions	interaction	NNS
cord-290802-761wqgbe	143	14	,	,	,
cord-290802-761wqgbe	143	15	notably	notably	RB
cord-290802-761wqgbe	143	16	N291	n291	JJ
cord-290802-761wqgbe	143	17	.	.	.
cord-290802-761wqgbe	144	1	Another	another	DT
cord-290802-761wqgbe	144	2	difference	difference	NN
cord-290802-761wqgbe	144	3	occurs	occur	VBZ
cord-290802-761wqgbe	144	4	in	in	IN
cord-290802-761wqgbe	144	5	motif	motif	NN
cord-290802-761wqgbe	144	6	E	e	NN
cord-290802-761wqgbe	144	7	;	;	:
cord-290802-761wqgbe	144	8	only	only	RB
cord-290802-761wqgbe	144	9	residue	residue	NN
cord-290802-761wqgbe	144	10	C366	C366	NNS
cord-290802-761wqgbe	144	11	from	from	IN
cord-290802-761wqgbe	144	12	the	the	DT
cord-290802-761wqgbe	144	13	hairpin	hairpin	NN
cord-290802-761wqgbe	144	14	loop	loop	NN
cord-290802-761wqgbe	144	15	interacts	interact	VBZ
cord-290802-761wqgbe	144	16	with	with	IN
cord-290802-761wqgbe	144	17	the	the	DT
cord-290802-761wqgbe	144	18	ligand	ligand	NN
cord-290802-761wqgbe	144	19	,	,	,
cord-290802-761wqgbe	144	20	differing	differ	VBG
cord-290802-761wqgbe	144	21	from	from	IN
cord-290802-761wqgbe	144	22	Class	Class	NNP
cord-290802-761wqgbe	144	23	III	III	NNP
cord-290802-761wqgbe	144	24	,	,	,
cord-290802-761wqgbe	144	25	which	which	WDT
cord-290802-761wqgbe	144	26	involves	involve	VBZ
cord-290802-761wqgbe	144	27	additional	additional	JJ
cord-290802-761wqgbe	144	28	residues	residue	NNS
cord-290802-761wqgbe	144	29	.	.	.
cord-290802-761wqgbe	145	1	Interestingly	interestingly	RB
cord-290802-761wqgbe	145	2	,	,	,
cord-290802-761wqgbe	145	3	within	within	IN
cord-290802-761wqgbe	145	4	motif	motif	NN
cord-290802-761wqgbe	145	5	E	e	NN
cord-290802-761wqgbe	145	6	,	,	,
cord-290802-761wqgbe	145	7	C366	C366	NNP
cord-290802-761wqgbe	145	8	is	be	VBZ
cord-290802-761wqgbe	145	9	highly	highly	RB
cord-290802-761wqgbe	145	10	conserved	conserve	VBN
cord-290802-761wqgbe	145	11	(	(	-LRB-
cord-290802-761wqgbe	145	12	Figure	figure	NN
cord-290802-761wqgbe	145	13	4	4	CD
cord-290802-761wqgbe	145	14	)	)	-RRB-
cord-290802-761wqgbe	145	15	.	.	.
cord-290802-761wqgbe	146	1	In	in	IN
cord-290802-761wqgbe	146	2	the	the	DT
cord-290802-761wqgbe	146	3	Thumb	Thumb	NNP
cord-290802-761wqgbe	146	4	domain	domain	NN
cord-290802-761wqgbe	146	5	,	,	,
cord-290802-761wqgbe	146	6	there	there	EX
cord-290802-761wqgbe	146	7	are	be	VBP
cord-290802-761wqgbe	146	8	interactions	interaction	NNS
cord-290802-761wqgbe	146	9	not	not	RB
cord-290802-761wqgbe	146	10	found	find	VBN
cord-290802-761wqgbe	146	11	in	in	IN
cord-290802-761wqgbe	146	12	the	the	DT
cord-290802-761wqgbe	146	13	other	other	JJ
cord-290802-761wqgbe	146	14	classes	class	NNS
cord-290802-761wqgbe	146	15	.	.	.
cord-290802-761wqgbe	147	1	Thus	thus	RB
cord-290802-761wqgbe	147	2	,	,	,
cord-290802-761wqgbe	147	3	in	in	IN
cord-290802-761wqgbe	147	4	class	class	NN
cord-290802-761wqgbe	147	5	IV	IV	NNP
cord-290802-761wqgbe	147	6	,	,	,
cord-290802-761wqgbe	147	7	the	the	DT
cord-290802-761wqgbe	147	8	pocket	pocket	NN
cord-290802-761wqgbe	147	9	is	be	VBZ
cord-290802-761wqgbe	147	10	composed	compose	VBN
cord-290802-761wqgbe	147	11	of	of	IN
cord-290802-761wqgbe	147	12	the	the	DT
cord-290802-761wqgbe	147	13	thumb	thumb	NN
cord-290802-761wqgbe	147	14	domain	domain	NN
cord-290802-761wqgbe	147	15	,	,	,
cord-290802-761wqgbe	147	16	motifs	motifs	NNP
cord-290802-761wqgbe	147	17	B	b	NN
cord-290802-761wqgbe	147	18	,	,	,
cord-290802-761wqgbe	147	19	C	C	NNP
cord-290802-761wqgbe	147	20	,	,	,
cord-290802-761wqgbe	147	21	and	and	CC
cord-290802-761wqgbe	147	22	E	e	LS
cord-290802-761wqgbe	147	23	(	(	-LRB-
cord-290802-761wqgbe	147	24	Figure	figure	NN
cord-290802-761wqgbe	147	25	5d	5d	CD
cord-290802-761wqgbe	147	26	)	)	-RRB-
cord-290802-761wqgbe	147	27	.	.	.
cord-290802-761wqgbe	148	1	In	in	IN
cord-290802-761wqgbe	148	2	summary	summary	NN
cord-290802-761wqgbe	148	3	,	,	,
cord-290802-761wqgbe	148	4	according	accord	VBG
cord-290802-761wqgbe	148	5	to	to	IN
cord-290802-761wqgbe	148	6	our	-PRON-	PRP$
cord-290802-761wqgbe	148	7	clustering	clustering	NN
cord-290802-761wqgbe	148	8	analysis	analysis	NN
cord-290802-761wqgbe	148	9	,	,	,
cord-290802-761wqgbe	148	10	there	there	EX
cord-290802-761wqgbe	148	11	are	be	VBP
cord-290802-761wqgbe	148	12	four	four	CD
cord-290802-761wqgbe	148	13	distinct	distinct	JJ
cord-290802-761wqgbe	148	14	binding	bind	VBG
cord-290802-761wqgbe	148	15	modes	mode	NNS
cord-290802-761wqgbe	148	16	in	in	IN
cord-290802-761wqgbe	148	17	the	the	DT
cord-290802-761wqgbe	148	18	conserved	conserve	VBN
cord-290802-761wqgbe	148	19	core	core	NN
cord-290802-761wqgbe	148	20	architecture	architecture	NN
cord-290802-761wqgbe	148	21	of	of	IN
cord-290802-761wqgbe	148	22	RDRP	RDRP	NNP
cord-290802-761wqgbe	148	23	,	,	,
cord-290802-761wqgbe	148	24	each	each	DT
cord-290802-761wqgbe	148	25	with	with	IN
cord-290802-761wqgbe	148	26	different	different	JJ
cord-290802-761wqgbe	148	27	subpockets	subpocket	NNS
cord-290802-761wqgbe	148	28	to	to	TO
cord-290802-761wqgbe	148	29	accommodate	accommodate	VB
cord-290802-761wqgbe	148	30	diverse	diverse	JJ
cord-290802-761wqgbe	148	31	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	148	32	.	.	.
cord-290802-761wqgbe	149	1	Classes	class	NNS
cord-290802-761wqgbe	150	1	I	-PRON-	PRP
cord-290802-761wqgbe	150	2	,	,	,
cord-290802-761wqgbe	150	3	III	III	NNP
cord-290802-761wqgbe	150	4	,	,	,
cord-290802-761wqgbe	150	5	and	and	CC
cord-290802-761wqgbe	150	6	IV	IV	NNP
cord-290802-761wqgbe	150	7	have	have	VBP
cord-290802-761wqgbe	150	8	helix1	helix1	NN
cord-290802-761wqgbe	150	9	and	and	CC
cord-290802-761wqgbe	150	10	motif	motif	NN
cord-290802-761wqgbe	150	11	E	e	NN
cord-290802-761wqgbe	151	1	that	that	IN
cord-290802-761wqgbe	151	2	always	always	RB
cord-290802-761wqgbe	151	3	participate	participate	VBP
cord-290802-761wqgbe	151	4	in	in	IN
cord-290802-761wqgbe	151	5	ligand	ligand	NN
cord-290802-761wqgbe	151	6	-	-	HYPH
cord-290802-761wqgbe	151	7	binding	bind	VBG
cord-290802-761wqgbe	151	8	interactions	interaction	NNS
cord-290802-761wqgbe	151	9	;	;	:
cord-290802-761wqgbe	151	10	hence	hence	RB
cord-290802-761wqgbe	151	11	,	,	,
cord-290802-761wqgbe	151	12	their	-PRON-	PRP$
cord-290802-761wqgbe	151	13	binding	bind	VBG
cord-290802-761wqgbe	151	14	pockets	pocket	NNS
cord-290802-761wqgbe	151	15	have	have	VBP
cord-290802-761wqgbe	151	16	a	a	DT
cord-290802-761wqgbe	151	17	common	common	JJ
cord-290802-761wqgbe	151	18	overlap	overlap	NN
cord-290802-761wqgbe	151	19	.	.	.
cord-290802-761wqgbe	152	1	Class	Class	NNP
cord-290802-761wqgbe	152	2	II	II	NNP
cord-290802-761wqgbe	152	3	has	have	VBZ
cord-290802-761wqgbe	152	4	a	a	DT
cord-290802-761wqgbe	152	5	different	different	JJ
cord-290802-761wqgbe	152	6	subpocket	subpocket	NN
cord-290802-761wqgbe	152	7	,	,	,
cord-290802-761wqgbe	152	8	which	which	WDT
cord-290802-761wqgbe	152	9	has	have	VBZ
cord-290802-761wqgbe	152	10	been	be	VBN
cord-290802-761wqgbe	152	11	exploited	exploit	VBN
cord-290802-761wqgbe	152	12	as	as	IN
cord-290802-761wqgbe	152	13	a	a	DT
cord-290802-761wqgbe	152	14	primary	primary	JJ
cord-290802-761wqgbe	152	15	target	target	NN
cord-290802-761wqgbe	152	16	11	11	CD
cord-290802-761wqgbe	152	17	for	for	IN
cord-290802-761wqgbe	152	18	studying	study	VBG
cord-290802-761wqgbe	152	19	the	the	DT
cord-290802-761wqgbe	152	20	drug	drug	NN
cord-290802-761wqgbe	152	21	remdesivir	remdesivir	NNP
cord-290802-761wqgbe	152	22	to	to	TO
cord-290802-761wqgbe	152	23	fight	fight	VB
cord-290802-761wqgbe	152	24	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	152	25	.	.	.
cord-290802-761wqgbe	152	26	11	11	CD
cord-290802-761wqgbe	153	1	With	with	IN
cord-290802-761wqgbe	153	2	the	the	DT
cord-290802-761wqgbe	153	3	above	above	RB
cord-290802-761wqgbe	153	4	-	-	HYPH
cord-290802-761wqgbe	153	5	mentioned	mention	VBN
cord-290802-761wqgbe	153	6	binding	binding	NN
cord-290802-761wqgbe	153	7	classes	class	NNS
cord-290802-761wqgbe	153	8	in	in	IN
cord-290802-761wqgbe	153	9	mind	mind	NN
cord-290802-761wqgbe	153	10	,	,	,
cord-290802-761wqgbe	153	11	we	-PRON-	PRP
cord-290802-761wqgbe	153	12	screened	screen	VBD
cord-290802-761wqgbe	153	13	7894	7894	CD
cord-290802-761wqgbe	153	14	FDA	FDA	NNP
cord-290802-761wqgbe	153	15	-	-	HYPH
cord-290802-761wqgbe	153	16	approved	approve	VBN
cord-290802-761wqgbe	153	17	small	small	JJ
cord-290802-761wqgbe	153	18	-	-	HYPH
cord-290802-761wqgbe	153	19	molecule	molecule	NN
cord-290802-761wqgbe	153	20	drugs	drug	NNS
cord-290802-761wqgbe	153	21	targeting	target	VBG
cord-290802-761wqgbe	153	22	the	the	DT
cord-290802-761wqgbe	153	23	RDRP	RDRP	NNP
cord-290802-761wqgbe	153	24	catalytic	catalytic	JJ
cord-290802-761wqgbe	153	25	domain	domain	NN
cord-290802-761wqgbe	153	26	.	.	.
cord-290802-761wqgbe	154	1	In	in	IN
cord-290802-761wqgbe	154	2	so	so	RB
cord-290802-761wqgbe	154	3	doing	do	VBG
cord-290802-761wqgbe	154	4	,	,	,
cord-290802-761wqgbe	154	5	we	-PRON-	PRP
cord-290802-761wqgbe	154	6	recognize	recognize	VBP
cord-290802-761wqgbe	154	7	the	the	DT
cord-290802-761wqgbe	154	8	limitations	limitation	NNS
cord-290802-761wqgbe	154	9	of	of	IN
cord-290802-761wqgbe	154	10	such	such	JJ
cord-290802-761wqgbe	154	11	in	in	IN
cord-290802-761wqgbe	154	12	silico	silico	NN
cord-290802-761wqgbe	154	13	findings	finding	NNS
cord-290802-761wqgbe	154	14	;	;	:
cord-290802-761wqgbe	154	15	they	-PRON-	PRP
cord-290802-761wqgbe	154	16	are	be	VBP
cord-290802-761wqgbe	154	17	nothing	nothing	NN
cord-290802-761wqgbe	154	18	more	more	JJR
cord-290802-761wqgbe	154	19	than	than	IN
cord-290802-761wqgbe	154	20	suggestions	suggestion	NNS
cord-290802-761wqgbe	154	21	requiring	require	VBG
cord-290802-761wqgbe	154	22	experimental	experimental	JJ
cord-290802-761wqgbe	154	23	validation	validation	NN
cord-290802-761wqgbe	154	24	.	.	.
cord-290802-761wqgbe	155	1	Two	two	CD
cord-290802-761wqgbe	155	2	different	different	JJ
cord-290802-761wqgbe	155	3	subpockets	subpocket	NNS
cord-290802-761wqgbe	155	4	were	be	VBD
cord-290802-761wqgbe	155	5	chosen	choose	VBN
cord-290802-761wqgbe	155	6	as	as	IN
cord-290802-761wqgbe	155	7	the	the	DT
cord-290802-761wqgbe	155	8	binding	bind	VBG
cord-290802-761wqgbe	155	9	pockets	pocket	NNS
cord-290802-761wqgbe	155	10	.	.	.
cord-290802-761wqgbe	156	1	Subpocket	subpocket	NN
cord-290802-761wqgbe	156	2	1	1	CD
cord-290802-761wqgbe	156	3	is	be	VBZ
cord-290802-761wqgbe	156	4	located	locate	VBN
cord-290802-761wqgbe	156	5	within	within	IN
cord-290802-761wqgbe	156	6	class	class	NN
cord-290802-761wqgbe	156	7	II	II	NNP
cord-290802-761wqgbe	156	8	and	and	CC
cord-290802-761wqgbe	156	9	subpocket	subpocket	NNP
cord-290802-761wqgbe	156	10	2	2	CD
cord-290802-761wqgbe	156	11	is	be	VBZ
cord-290802-761wqgbe	156	12	located	locate	VBN
cord-290802-761wqgbe	156	13	in	in	IN
cord-290802-761wqgbe	156	14	the	the	DT
cord-290802-761wqgbe	156	15	area	area	NN
cord-290802-761wqgbe	156	16	centered	center	VBN
cord-290802-761wqgbe	156	17	on	on	IN
cord-290802-761wqgbe	156	18	the	the	DT
cord-290802-761wqgbe	156	19	common	common	JJ
cord-290802-761wqgbe	156	20	region	region	NN
cord-290802-761wqgbe	156	21	of	of	IN
cord-290802-761wqgbe	156	22	classes	class	NNS
cord-290802-761wqgbe	156	23	I	-PRON-	PRP
cord-290802-761wqgbe	156	24	,	,	,
cord-290802-761wqgbe	156	25	III	III	NNP
cord-290802-761wqgbe	156	26	,	,	,
cord-290802-761wqgbe	156	27	and	and	CC
cord-290802-761wqgbe	156	28	IV	IV	NNP
cord-290802-761wqgbe	156	29	(	(	-LRB-
cord-290802-761wqgbe	156	30	see	see	VB
cord-290802-761wqgbe	156	31	the	the	DT
cord-290802-761wqgbe	156	32	two	two	CD
cord-290802-761wqgbe	156	33	subpockets	subpocket	NNS
cord-290802-761wqgbe	156	34	highlighted	highlight	VBN
cord-290802-761wqgbe	156	35	with	with	IN
cord-290802-761wqgbe	156	36	spheres	sphere	NNS
cord-290802-761wqgbe	156	37	44	44	CD
cord-290802-761wqgbe	156	38	in	in	IN
cord-290802-761wqgbe	156	39	Figure	Figure	NNP
cord-290802-761wqgbe	156	40	S3	S3	NNP
cord-290802-761wqgbe	156	41	)	)	-RRB-
cord-290802-761wqgbe	156	42	.	.	.
cord-290802-761wqgbe	157	1	Through	through	IN
cord-290802-761wqgbe	157	2	virtual	virtual	JJ
cord-290802-761wqgbe	157	3	screening	screening	NN
cord-290802-761wqgbe	157	4	(	(	-LRB-
cord-290802-761wqgbe	157	5	see	see	VB
cord-290802-761wqgbe	157	6	Methods	Methods	NNPS
cord-290802-761wqgbe	157	7	)	)	-RRB-
cord-290802-761wqgbe	157	8	,	,	,
cord-290802-761wqgbe	157	9	the	the	DT
cord-290802-761wqgbe	157	10	top	top	JJ
cord-290802-761wqgbe	157	11	-	-	HYPH
cord-290802-761wqgbe	157	12	five	five	CD
cord-290802-761wqgbe	157	13	highest	high	JJS
cord-290802-761wqgbe	157	14	scoring	scoring	NN
cord-290802-761wqgbe	157	15	compounds	compound	NNS
cord-290802-761wqgbe	157	16	against	against	IN
cord-290802-761wqgbe	157	17	each	each	DT
cord-290802-761wqgbe	157	18	subpocket	subpocket	NN
cord-290802-761wqgbe	157	19	are	be	VBP
cord-290802-761wqgbe	157	20	listed	list	VBN
cord-290802-761wqgbe	157	21	in	in	IN
cord-290802-761wqgbe	157	22	Table	Table	NNP
cord-290802-761wqgbe	157	23	2	2	CD
cord-290802-761wqgbe	157	24	.	.	.
cord-290802-761wqgbe	158	1	For	for	IN
cord-290802-761wqgbe	158	2	subpocket	subpocket	NNP
cord-290802-761wqgbe	158	3	1	1	CD
cord-290802-761wqgbe	158	4	,	,	,
cord-290802-761wqgbe	158	5	there	there	EX
cord-290802-761wqgbe	158	6	is	be	VBZ
cord-290802-761wqgbe	158	7	an	an	DT
cord-290802-761wqgbe	158	8	inhibitor	inhibitor	NN
cord-290802-761wqgbe	158	9	of	of	IN
cord-290802-761wqgbe	158	10	factor	factor	NN
cord-290802-761wqgbe	158	11	Xa	Xa	NNP
cord-290802-761wqgbe	158	12	(	(	-LRB-
cord-290802-761wqgbe	158	13	Darexaban	Darexaban	NNP
cord-290802-761wqgbe	158	14	)	)	-RRB-
cord-290802-761wqgbe	158	15	,	,	,
cord-290802-761wqgbe	158	16	49	49	CD
cord-290802-761wqgbe	158	17	which	which	WDT
cord-290802-761wqgbe	158	18	prevents	prevent	VBZ
cord-290802-761wqgbe	158	19	venous	venous	JJ
cord-290802-761wqgbe	158	20	thromboembolism	thromboembolism	NN
cord-290802-761wqgbe	158	21	by	by	IN
cord-290802-761wqgbe	158	22	acting	act	VBG
cord-290802-761wqgbe	158	23	as	as	IN
cord-290802-761wqgbe	158	24	an	an	DT
cord-290802-761wqgbe	158	25	anticoagulant	anticoagulant	JJ
cord-290802-761wqgbe	158	26	and	and	CC
cord-290802-761wqgbe	158	27	antithrombotic	antithrombotic	JJ
cord-290802-761wqgbe	158	28	after	after	IN
cord-290802-761wqgbe	158	29	surgery	surgery	NN
cord-290802-761wqgbe	158	30	;	;	:
cord-290802-761wqgbe	158	31	two	two	CD
cord-290802-761wqgbe	158	32	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	158	33	of	of	IN
cord-290802-761wqgbe	158	34	histone	histone	NN
cord-290802-761wqgbe	158	35	deacetylase	deacetylase	NN
cord-290802-761wqgbe	158	36	(	(	-LRB-
cord-290802-761wqgbe	158	37	4SC-202	4sc-202	CD
cord-290802-761wqgbe	158	38	and	and	CC
cord-290802-761wqgbe	158	39	CUDC-907	CUDC-907	NNP
cord-290802-761wqgbe	158	40	)	)	-RRB-
cord-290802-761wqgbe	158	41	;	;	:
cord-290802-761wqgbe	158	42	50,51	50,51	CD
cord-290802-761wqgbe	158	43	an	an	DT
cord-290802-761wqgbe	158	44	inhibitor	inhibitor	NN
cord-290802-761wqgbe	158	45	of	of	IN
cord-290802-761wqgbe	158	46	dipeptidyl	dipeptidyl	JJ
cord-290802-761wqgbe	158	47	peptidase	peptidase	NN
cord-290802-761wqgbe	158	48	4	4	CD
cord-290802-761wqgbe	158	49	(	(	-LRB-
cord-290802-761wqgbe	158	50	DB07779	DB07779	NNP
cord-290802-761wqgbe	158	51	)	)	-RRB-
cord-290802-761wqgbe	158	52	;	;	:
cord-290802-761wqgbe	158	53	22	22	CD
cord-290802-761wqgbe	158	54	and	and	CC
cord-290802-761wqgbe	158	55	an	an	DT
cord-290802-761wqgbe	158	56	inhibitor	inhibitor	NN
cord-290802-761wqgbe	158	57	of	of	IN
cord-290802-761wqgbe	158	58	EGFR	EGFR	NNP
cord-290802-761wqgbe	158	59	(	(	-LRB-
cord-290802-761wqgbe	158	60	Osimertinib	Osimertinib	NNP
cord-290802-761wqgbe	158	61	)	)	-RRB-
cord-290802-761wqgbe	158	62	.	.	.
cord-290802-761wqgbe	159	1	52	52	CD
cord-290802-761wqgbe	160	1	These	these	DT
cord-290802-761wqgbe	160	2	subpocket	subpocket	NN
cord-290802-761wqgbe	160	3	1	1	CD
cord-290802-761wqgbe	160	4	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	160	5	interact	interact	VBP
cord-290802-761wqgbe	160	6	with	with	IN
cord-290802-761wqgbe	160	7	Motifs	Motifs	NNP
cord-290802-761wqgbe	160	8	A−D	A−D	NNP
cord-290802-761wqgbe	160	9	and	and	CC
cord-290802-761wqgbe	160	10	F	F	NNP
cord-290802-761wqgbe	160	11	and	and	CC
cord-290802-761wqgbe	160	12	G	G	NNP
cord-290802-761wqgbe	160	13	(	(	-LRB-
cord-290802-761wqgbe	160	14	Figure	figure	NN
cord-290802-761wqgbe	160	15	6a	6a	CD
cord-290802-761wqgbe	160	16	)	)	-RRB-
cord-290802-761wqgbe	160	17	.	.	.
cord-290802-761wqgbe	161	1	For	for	IN
cord-290802-761wqgbe	161	2	comparison	comparison	NN
cord-290802-761wqgbe	161	3	,	,	,
cord-290802-761wqgbe	161	4	remdesivir	remdesivir	NNP
cord-290802-761wqgbe	161	5	(	(	-LRB-
cord-290802-761wqgbe	161	6	accession	accession	NN
cord-290802-761wqgbe	161	7	number	number	NN
cord-290802-761wqgbe	161	8	DB14761	DB14761	NNP
cord-290802-761wqgbe	161	9	)	)	-RRB-
cord-290802-761wqgbe	161	10	is	be	VBZ
cord-290802-761wqgbe	161	11	included	include	VBN
cord-290802-761wqgbe	161	12	in	in	IN
cord-290802-761wqgbe	161	13	our	-PRON-	PRP$
cord-290802-761wqgbe	161	14	compound	compound	NN
cord-290802-761wqgbe	161	15	library	library	NN
cord-290802-761wqgbe	161	16	,	,	,
cord-290802-761wqgbe	161	17	and	and	CC
cord-290802-761wqgbe	161	18	its	-PRON-	PRP$
cord-290802-761wqgbe	161	19	docking	docking	NN
cord-290802-761wqgbe	161	20	score	score	NN
cord-290802-761wqgbe	161	21	is	be	VBZ
cord-290802-761wqgbe	161	22	6.0	6.0	CD
cord-290802-761wqgbe	161	23	(	(	-LRB-
cord-290802-761wqgbe	161	24	Figure	figure	NN
cord-290802-761wqgbe	161	25	5b	5b	CD
cord-290802-761wqgbe	161	26	)	)	-RRB-
cord-290802-761wqgbe	161	27	,	,	,
cord-290802-761wqgbe	161	28	considerably	considerably	RB
cord-290802-761wqgbe	161	29	less	less	JJR
cord-290802-761wqgbe	161	30	than	than	IN
cord-290802-761wqgbe	161	31	our	-PRON-	PRP$
cord-290802-761wqgbe	161	32	top	top	JJ
cord-290802-761wqgbe	161	33	-	-	HYPH
cord-290802-761wqgbe	161	34	scoring	score	VBG
cord-290802-761wqgbe	161	35	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	161	36	.	.	.
cord-290802-761wqgbe	162	1	Screening	screening	NN
cord-290802-761wqgbe	162	2	of	of	IN
cord-290802-761wqgbe	162	3	subpocket	subpocket	NNP
cord-290802-761wqgbe	162	4	2	2	CD
cord-290802-761wqgbe	162	5	revealed	reveal	VBD
cord-290802-761wqgbe	162	6	five	five	CD
cord-290802-761wqgbe	162	7	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	162	8	with	with	IN
cord-290802-761wqgbe	162	9	a	a	DT
cord-290802-761wqgbe	162	10	binding	bind	VBG
cord-290802-761wqgbe	162	11	affinity	affinity	NN
cord-290802-761wqgbe	162	12	of	of	IN
cord-290802-761wqgbe	162	13	>	>	XX
cord-290802-761wqgbe	162	14	7.9	7.9	CD
cord-290802-761wqgbe	162	15	(	(	-LRB-
cord-290802-761wqgbe	162	16	Table	table	NN
cord-290802-761wqgbe	162	17	2	2	CD
cord-290802-761wqgbe	162	18	,	,	,
cord-290802-761wqgbe	162	19	Figure	figure	NN
cord-290802-761wqgbe	162	20	6b	6b	CD
cord-290802-761wqgbe	162	21	)	)	-RRB-
cord-290802-761wqgbe	162	22	.	.	.
cord-290802-761wqgbe	163	1	It	-PRON-	PRP
cord-290802-761wqgbe	163	2	is	be	VBZ
cord-290802-761wqgbe	163	3	noteworthy	noteworthy	JJ
cord-290802-761wqgbe	163	4	that	that	IN
cord-290802-761wqgbe	163	5	two	two	CD
cord-290802-761wqgbe	163	6	of	of	IN
cord-290802-761wqgbe	163	7	the	the	DT
cord-290802-761wqgbe	163	8	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	163	9	(	(	-LRB-
cord-290802-761wqgbe	163	10	LY-517717	LY-517717	NNS
cord-290802-761wqgbe	163	11	and	and	CC
cord-290802-761wqgbe	163	12	DB07074	db07074	NN
cord-290802-761wqgbe	163	13	)	)	-RRB-
cord-290802-761wqgbe	163	14	53	53	CD
cord-290802-761wqgbe	163	15	target	target	NN
cord-290802-761wqgbe	163	16	coagulation	coagulation	NN
cord-290802-761wqgbe	163	17	factors	factor	NNS
cord-290802-761wqgbe	163	18	X	X	NNS
cord-290802-761wqgbe	163	19	and	and	CC
cord-290802-761wqgbe	163	20	XI	XI	NNP
cord-290802-761wqgbe	163	21	,	,	,
cord-290802-761wqgbe	163	22	respectively	respectively	RB
cord-290802-761wqgbe	163	23	.	.	.
cord-290802-761wqgbe	164	1	It	-PRON-	PRP
cord-290802-761wqgbe	164	2	is	be	VBZ
cord-290802-761wqgbe	164	3	reported	report	VBN
cord-290802-761wqgbe	164	4	that	that	IN
cord-290802-761wqgbe	164	5	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	164	6	induces	induce	VBZ
cord-290802-761wqgbe	164	7	blood	blood	NN
cord-290802-761wqgbe	164	8	clotting	clotting	NN
cord-290802-761wqgbe	164	9	in	in	IN
cord-290802-761wqgbe	164	10	the	the	DT
cord-290802-761wqgbe	164	11	lungs	lung	NNS
cord-290802-761wqgbe	164	12	and	and	CC
cord-290802-761wqgbe	164	13	elsewhere	elsewhere	RB
cord-290802-761wqgbe	164	14	.	.	.
cord-290802-761wqgbe	165	1	54	54	CD
cord-290802-761wqgbe	165	2	,	,	,
cord-290802-761wqgbe	165	3	55	55	CD
cord-290802-761wqgbe	166	1	As	as	IN
cord-290802-761wqgbe	166	2	blood	blood	NN
cord-290802-761wqgbe	166	3	thinners	thinner	NNS
cord-290802-761wqgbe	166	4	,	,	,
cord-290802-761wqgbe	166	5	these	these	DT
cord-290802-761wqgbe	166	6	drugs	drug	NNS
cord-290802-761wqgbe	166	7	might	may	MD
cord-290802-761wqgbe	166	8	have	have	VB
cord-290802-761wqgbe	166	9	the	the	DT
cord-290802-761wqgbe	166	10	added	add	VBN
cord-290802-761wqgbe	166	11	value	value	NN
cord-290802-761wqgbe	166	12	of	of	IN
cord-290802-761wqgbe	166	13	reducing	reduce	VBG
cord-290802-761wqgbe	166	14	blood	blood	NN
cord-290802-761wqgbe	166	15	clotting	clotting	NN
cord-290802-761wqgbe	166	16	,	,	,
cord-290802-761wqgbe	166	17	56	56	CD
cord-290802-761wqgbe	166	18	and	and	CC
cord-290802-761wqgbe	166	19	indeed	indeed	RB
cord-290802-761wqgbe	166	20	,	,	,
cord-290802-761wqgbe	166	21	there	there	EX
cord-290802-761wqgbe	166	22	are	be	VBP
cord-290802-761wqgbe	166	23	multiple	multiple	JJ
cord-290802-761wqgbe	166	24	clinical	clinical	JJ
cord-290802-761wqgbe	166	25	trials	trial	NNS
cord-290802-761wqgbe	166	26	using	use	VBG
cord-290802-761wqgbe	166	27	anticoagulants	anticoagulant	NNS
cord-290802-761wqgbe	166	28	.	.	.
cord-290802-761wqgbe	167	1	57	57	CD
cord-290802-761wqgbe	168	1	Pentamidine	Pentamidine	NNP
cord-290802-761wqgbe	168	2	is	be	VBZ
cord-290802-761wqgbe	168	3	an	an	DT
cord-290802-761wqgbe	168	4	agent	agent	NN
cord-290802-761wqgbe	168	5	to	to	TO
cord-290802-761wqgbe	168	6	treat	treat	VB
cord-290802-761wqgbe	168	7	pneumocystis	pneumocystis	NN
cord-290802-761wqgbe	168	8	pneumonia	pneumonia	NN
cord-290802-761wqgbe	168	9	in	in	IN
cord-290802-761wqgbe	168	10	HIV	HIV	NNP
cord-290802-761wqgbe	168	11	-	-	HYPH
cord-290802-761wqgbe	168	12	infected	infect	VBN
cord-290802-761wqgbe	168	13	patients	patient	NNS
cord-290802-761wqgbe	168	14	.	.	.
cord-290802-761wqgbe	169	1	58	58	CD
cord-290802-761wqgbe	170	1	Nafamostat	Nafamostat	NNP
cord-290802-761wqgbe	170	2	is	be	VBZ
cord-290802-761wqgbe	170	3	a	a	DT
cord-290802-761wqgbe	170	4	short	short	RB
cord-290802-761wqgbe	170	5	-	-	HYPH
cord-290802-761wqgbe	170	6	acting	act	VBG
cord-290802-761wqgbe	170	7	anticoagulant	anticoagulant	NN
cord-290802-761wqgbe	170	8	,	,	,
cord-290802-761wqgbe	170	9	which	which	WDT
cord-290802-761wqgbe	170	10	acts	act	VBZ
cord-290802-761wqgbe	170	11	as	as	IN
cord-290802-761wqgbe	170	12	a	a	DT
cord-290802-761wqgbe	170	13	serine	serine	NN
cord-290802-761wqgbe	170	14	protease	protease	NN
cord-290802-761wqgbe	170	15	inhibitor	inhibitor	NN
cord-290802-761wqgbe	170	16	and	and	CC
cord-290802-761wqgbe	170	17	is	be	VBZ
cord-290802-761wqgbe	170	18	reported	report	VBN
cord-290802-761wqgbe	170	19	to	to	TO
cord-290802-761wqgbe	170	20	have	have	VB
cord-290802-761wqgbe	170	21	antiviral	antiviral	JJ
cord-290802-761wqgbe	170	22	properties	property	NNS
cord-290802-761wqgbe	170	23	,	,	,
cord-290802-761wqgbe	170	24	59	59	CD
cord-290802-761wqgbe	170	25	and	and	CC
cord-290802-761wqgbe	170	26	is	be	VBZ
cord-290802-761wqgbe	170	27	undergoing	undergo	VBG
cord-290802-761wqgbe	170	28	a	a	DT
cord-290802-761wqgbe	170	29	clinical	clinical	JJ
cord-290802-761wqgbe	170	30	trial	trial	NN
cord-290802-761wqgbe	170	31	in	in	IN
cord-290802-761wqgbe	170	32	Japan	Japan	NNP
cord-290802-761wqgbe	170	33	.	.	.
cord-290802-761wqgbe	171	1	To	to	TO
cord-290802-761wqgbe	171	2	summarize	summarize	VB
cord-290802-761wqgbe	171	3	,	,	,
cord-290802-761wqgbe	171	4	we	-PRON-	PRP
cord-290802-761wqgbe	171	5	characterized	characterize	VBD
cord-290802-761wqgbe	171	6	RDRP	RDRP	NNP
cord-290802-761wqgbe	171	7	binding	bind	VBG
cord-290802-761wqgbe	171	8	pockets	pocket	NNS
cord-290802-761wqgbe	171	9	,	,	,
cord-290802-761wqgbe	171	10	suggesting	suggest	VBG
cord-290802-761wqgbe	171	11	four	four	CD
cord-290802-761wqgbe	171	12	classes	class	NNS
cord-290802-761wqgbe	171	13	of	of	IN
cord-290802-761wqgbe	171	14	binding	bind	VBG
cord-290802-761wqgbe	171	15	modes	mode	NNS
cord-290802-761wqgbe	171	16	(	(	-LRB-
cord-290802-761wqgbe	171	17	classes	class	NNS
cord-290802-761wqgbe	171	18	I−IV	i−iv	JJ
cord-290802-761wqgbe	171	19	)	)	-RRB-
cord-290802-761wqgbe	171	20	.	.	.
cord-290802-761wqgbe	172	1	In	in	IN
cord-290802-761wqgbe	172	2	silico	silico	NN
cord-290802-761wqgbe	172	3	screening	screening	NN
cord-290802-761wqgbe	172	4	against	against	IN
cord-290802-761wqgbe	172	5	two	two	CD
cord-290802-761wqgbe	172	6	of	of	IN
cord-290802-761wqgbe	172	7	these	these	DT
cord-290802-761wqgbe	172	8	completely	completely	RB
cord-290802-761wqgbe	172	9	different	different	JJ
cord-290802-761wqgbe	172	10	pockets	pocket	NNS
cord-290802-761wqgbe	172	11	(	(	-LRB-
cord-290802-761wqgbe	172	12	subpockets	subpocket	NNS
cord-290802-761wqgbe	172	13	1	1	CD
cord-290802-761wqgbe	172	14	and	and	CC
cord-290802-761wqgbe	172	15	2	2	CD
cord-290802-761wqgbe	172	16	)	)	-RRB-
cord-290802-761wqgbe	172	17	provided	provide	VBD
cord-290802-761wqgbe	172	18	a	a	DT
cord-290802-761wqgbe	172	19	series	series	NN
cord-290802-761wqgbe	172	20	of	of	IN
cord-290802-761wqgbe	172	21	putative	putative	JJ
cord-290802-761wqgbe	172	22	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	172	23	with	with	IN
cord-290802-761wqgbe	172	24	a	a	DT
cord-290802-761wqgbe	172	25	high	high	JJ
cord-290802-761wqgbe	172	26	binding	binding	NN
cord-290802-761wqgbe	172	27	affinity	affinity	NN
cord-290802-761wqgbe	172	28	.	.	.
cord-290802-761wqgbe	173	1	Again	again	RB
cord-290802-761wqgbe	173	2	,	,	,
cord-290802-761wqgbe	173	3	we	-PRON-	PRP
cord-290802-761wqgbe	173	4	emphasize	emphasize	VBP
cord-290802-761wqgbe	173	5	that	that	IN
cord-290802-761wqgbe	173	6	experimental	experimental	JJ
cord-290802-761wqgbe	173	7	validation	validation	NN
cord-290802-761wqgbe	173	8	is	be	VBZ
cord-290802-761wqgbe	173	9	necessary	necessary	JJ
cord-290802-761wqgbe	173	10	to	to	TO
cord-290802-761wqgbe	173	11	draw	draw	VB
cord-290802-761wqgbe	173	12	any	any	DT
cord-290802-761wqgbe	173	13	meaning	meaning	NN
cord-290802-761wqgbe	173	14	from	from	IN
cord-290802-761wqgbe	173	15	this	this	DT
cord-290802-761wqgbe	173	16	putative	putative	JJ
cord-290802-761wqgbe	173	17	outcome	outcome	NN
cord-290802-761wqgbe	173	18	given	give	VBN
cord-290802-761wqgbe	173	19	,	,	,
cord-290802-761wqgbe	173	20	among	among	IN
cord-290802-761wqgbe	173	21	other	other	JJ
cord-290802-761wqgbe	173	22	possible	possible	JJ
cord-290802-761wqgbe	173	23	computational	computational	JJ
cord-290802-761wqgbe	173	24	inaccuracies	inaccuracy	NNS
cord-290802-761wqgbe	173	25	,	,	,
cord-290802-761wqgbe	173	26	the	the	DT
cord-290802-761wqgbe	173	27	unreliability	unreliability	NN
cord-290802-761wqgbe	173	28	of	of	IN
cord-290802-761wqgbe	173	29	such	such	JJ
cord-290802-761wqgbe	173	30	binding	binding	JJ
cord-290802-761wqgbe	173	31	affinities	affinity	NNS
cord-290802-761wqgbe	173	32	.	.	.
cord-290802-761wqgbe	174	1	In	in	IN
cord-290802-761wqgbe	174	2	this	this	DT
cord-290802-761wqgbe	174	3	paper	paper	NN
cord-290802-761wqgbe	174	4	,	,	,
cord-290802-761wqgbe	174	5	we	-PRON-	PRP
cord-290802-761wqgbe	174	6	explored	explore	VBD
cord-290802-761wqgbe	174	7	the	the	DT
cord-290802-761wqgbe	174	8	structural	structural	JJ
cord-290802-761wqgbe	174	9	characteristics	characteristic	NNS
cord-290802-761wqgbe	174	10	of	of	IN
cord-290802-761wqgbe	174	11	the	the	DT
cord-290802-761wqgbe	174	12	RDRP	RDRP	NNP
cord-290802-761wqgbe	174	13	catalytic	catalytic	JJ
cord-290802-761wqgbe	174	14	domain	domain	NN
cord-290802-761wqgbe	174	15	using	use	VBG
cord-290802-761wqgbe	174	16	a	a	DT
cord-290802-761wqgbe	174	17	computational	computational	JJ
cord-290802-761wqgbe	174	18	pharmacology	pharmacology	NN
cord-290802-761wqgbe	174	19	method	method	NN
cord-290802-761wqgbe	174	20	.	.	.
cord-290802-761wqgbe	175	1	More	more	RBR
cord-290802-761wqgbe	175	2	specifically	specifically	RB
cord-290802-761wqgbe	175	3	,	,	,
cord-290802-761wqgbe	175	4	we	-PRON-	PRP
cord-290802-761wqgbe	175	5	focused	focus	VBD
cord-290802-761wqgbe	175	6	on	on	IN
cord-290802-761wqgbe	175	7	the	the	DT
cord-290802-761wqgbe	175	8	ligand	ligand	NN
cord-290802-761wqgbe	175	9	-	-	HYPH
cord-290802-761wqgbe	175	10	binding	bind	VBG
cord-290802-761wqgbe	175	11	characteristics	characteristic	NNS
cord-290802-761wqgbe	175	12	of	of	IN
cord-290802-761wqgbe	175	13	the	the	DT
cord-290802-761wqgbe	175	14	RDRP	RDRP	NNP
cord-290802-761wqgbe	175	15	binding	binding	NN
cord-290802-761wqgbe	175	16	site	site	NN
cord-290802-761wqgbe	175	17	using	use	VBG
cord-290802-761wqgbe	175	18	a	a	DT
cord-290802-761wqgbe	175	19	receptor−	receptor−	NN
cord-290802-761wqgbe	175	20	ligand	ligand	NN
cord-290802-761wqgbe	175	21	function	function	NN
cord-290802-761wqgbe	175	22	-	-	HYPH
cord-290802-761wqgbe	175	23	site	site	NN
cord-290802-761wqgbe	175	24	interaction	interaction	NN
cord-290802-761wqgbe	175	25	fingerprint	fingerprint	NN
cord-290802-761wqgbe	175	26	strategy	strategy	NN
cord-290802-761wqgbe	175	27	.	.	.
cord-290802-761wqgbe	176	1	We	-PRON-	PRP
cord-290802-761wqgbe	176	2	collected	collect	VBD
cord-290802-761wqgbe	176	3	all	all	DT
cord-290802-761wqgbe	176	4	available	available	JJ
cord-290802-761wqgbe	176	5	RDRP	RDRP	NNP
cord-290802-761wqgbe	176	6	structures	structure	NNS
cord-290802-761wqgbe	176	7	and	and	CC
cord-290802-761wqgbe	176	8	analyzed	analyze	VBD
cord-290802-761wqgbe	176	9	the	the	DT
cord-290802-761wqgbe	176	10	conserved	conserve	VBN
cord-290802-761wqgbe	176	11	core	core	NN
cord-290802-761wqgbe	176	12	structure	structure	NN
cord-290802-761wqgbe	176	13	.	.	.
cord-290802-761wqgbe	177	1	Across	across	IN
cord-290802-761wqgbe	177	2	the	the	DT
cord-290802-761wqgbe	177	3	entire	entire	JJ
cord-290802-761wqgbe	177	4	data	data	NN
cord-290802-761wqgbe	177	5	set	set	NN
cord-290802-761wqgbe	177	6	,	,	,
cord-290802-761wqgbe	177	7	a	a	DT
cord-290802-761wqgbe	177	8	"	"	``
cord-290802-761wqgbe	177	9	cupped	cup	VBN
cord-290802-761wqgbe	177	10	right	right	JJ
cord-290802-761wqgbe	177	11	hand	hand	NN
cord-290802-761wqgbe	177	12	"	"	''
cord-290802-761wqgbe	177	13	folding	folding	NN
cord-290802-761wqgbe	177	14	pattern	pattern	NN
cord-290802-761wqgbe	177	15	and	and	CC
cord-290802-761wqgbe	177	16	7	7	CD
cord-290802-761wqgbe	177	17	conserved	conserved	JJ
cord-290802-761wqgbe	177	18	motifs	motif	NNS
cord-290802-761wqgbe	177	19	characterize	characterize	VBP
cord-290802-761wqgbe	177	20	a	a	DT
cord-290802-761wqgbe	177	21	highly	highly	RB
cord-290802-761wqgbe	177	22	similar	similar	JJ
cord-290802-761wqgbe	177	23	RDRP	rdrp	NN
cord-290802-761wqgbe	177	24	architecture	architecture	NN
cord-290802-761wqgbe	177	25	.	.	.
cord-290802-761wqgbe	178	1	By	by	IN
cord-290802-761wqgbe	178	2	analyzing	analyze	VBG
cord-290802-761wqgbe	178	3	these	these	DT
cord-290802-761wqgbe	178	4	protein−ligand	protein−ligand	CD
cord-290802-761wqgbe	178	5	complexes	complex	NNS
cord-290802-761wqgbe	178	6	with	with	IN
cord-290802-761wqgbe	178	7	an	an	DT
cord-290802-761wqgbe	178	8	overall	overall	JJ
cord-290802-761wqgbe	178	9	shared	share	VBN
cord-290802-761wqgbe	178	10	architecture	architecture	NN
cord-290802-761wqgbe	178	11	,	,	,
cord-290802-761wqgbe	178	12	four	four	CD
cord-290802-761wqgbe	178	13	different	different	JJ
cord-290802-761wqgbe	178	14	classes	class	NNS
cord-290802-761wqgbe	178	15	of	of	IN
cord-290802-761wqgbe	178	16	binding	bind	VBG
cord-290802-761wqgbe	178	17	modes	mode	NNS
cord-290802-761wqgbe	178	18	were	be	VBD
cord-290802-761wqgbe	178	19	revealed	reveal	VBN
cord-290802-761wqgbe	178	20	.	.	.
cord-290802-761wqgbe	179	1	Class	Class	NNP
cord-290802-761wqgbe	179	2	II	II	NNP
cord-290802-761wqgbe	179	3	is	be	VBZ
cord-290802-761wqgbe	179	4	based	base	VBN
cord-290802-761wqgbe	179	5	on	on	IN
cord-290802-761wqgbe	179	6	the	the	DT
cord-290802-761wqgbe	179	7	pocket	pocket	NN
cord-290802-761wqgbe	179	8	consisting	consist	VBG
cord-290802-761wqgbe	179	9	of	of	IN
cord-290802-761wqgbe	179	10	motifs	motif	NNS
cord-290802-761wqgbe	179	11	A−D	A−D	NNP
cord-290802-761wqgbe	179	12	and	and	CC
cord-290802-761wqgbe	179	13	F	F	NNP
cord-290802-761wqgbe	179	14	and	and	CC
cord-290802-761wqgbe	179	15	G	G	NNP
cord-290802-761wqgbe	179	16	,	,	,
cord-290802-761wqgbe	179	17	whereas	whereas	IN
cord-290802-761wqgbe	179	18	classes	class	NNS
cord-290802-761wqgbe	180	1	I	-PRON-	PRP
cord-290802-761wqgbe	180	2	,	,	,
cord-290802-761wqgbe	180	3	III	III	NNP
cord-290802-761wqgbe	180	4	,	,	,
cord-290802-761wqgbe	180	5	and	and	CC
cord-290802-761wqgbe	180	6	IV	IV	NNP
cord-290802-761wqgbe	180	7	have	have	VBP
cord-290802-761wqgbe	180	8	distinct	distinct	JJ
cord-290802-761wqgbe	180	9	yet	yet	CC
cord-290802-761wqgbe	180	10	somewhat	somewhat	RB
cord-290802-761wqgbe	180	11	overlapping	overlap	VBG
cord-290802-761wqgbe	180	12	characteristics	characteristic	NNS
cord-290802-761wqgbe	180	13	;	;	:
cord-290802-761wqgbe	180	14	for	for	IN
cord-290802-761wqgbe	180	15	example	example	NN
cord-290802-761wqgbe	180	16	,	,	,
cord-290802-761wqgbe	180	17	helix1	helix1	JJ
cord-290802-761wqgbe	180	18	and	and	CC
cord-290802-761wqgbe	180	19	motif	motif	NN
cord-290802-761wqgbe	180	20	E	e	NN
cord-290802-761wqgbe	180	21	always	always	RB
cord-290802-761wqgbe	180	22	participate	participate	VB
cord-290802-761wqgbe	180	23	in	in	IN
cord-290802-761wqgbe	180	24	ligand	ligand	NN
cord-290802-761wqgbe	180	25	binding	binding	NN
cord-290802-761wqgbe	180	26	.	.	.
cord-290802-761wqgbe	181	1	In	in	IN
cord-290802-761wqgbe	181	2	terms	term	NNS
cord-290802-761wqgbe	181	3	of	of	IN
cord-290802-761wqgbe	181	4	distinct	distinct	JJ
cord-290802-761wqgbe	181	5	characteristics	characteristic	NNS
cord-290802-761wqgbe	181	6	,	,	,
cord-290802-761wqgbe	181	7	class	class	NN
cord-290802-761wqgbe	181	8	I	-PRON-	PRP
cord-290802-761wqgbe	181	9	has	have	VBZ
cord-290802-761wqgbe	181	10	a	a	DT
cord-290802-761wqgbe	181	11	unique	unique	JJ
cord-290802-761wqgbe	181	12	binding	binding	NN
cord-290802-761wqgbe	181	13	mode	mode	NN
cord-290802-761wqgbe	181	14	in	in	IN
cord-290802-761wqgbe	181	15	the	the	DT
cord-290802-761wqgbe	181	16	thumb	thumb	NN
cord-290802-761wqgbe	181	17	domain	domain	NN
cord-290802-761wqgbe	181	18	,	,	,
cord-290802-761wqgbe	181	19	class	class	NN
cord-290802-761wqgbe	181	20	III	iii	NN
cord-290802-761wqgbe	181	21	in	in	IN
cord-290802-761wqgbe	181	22	motif	motif	NN
cord-290802-761wqgbe	181	23	E	e	NN
cord-290802-761wqgbe	181	24	,	,	,
cord-290802-761wqgbe	181	25	and	and	CC
cord-290802-761wqgbe	181	26	class	class	NN
cord-290802-761wqgbe	181	27	IV	IV	NNP
cord-290802-761wqgbe	181	28	in	in	IN
cord-290802-761wqgbe	181	29	motifs	motif	NNS
cord-290802-761wqgbe	181	30	B	B	NNP
cord-290802-761wqgbe	181	31	and	and	CC
cord-290802-761wqgbe	181	32	E.	E.	NNP
cord-290802-761wqgbe	182	1	On	on	IN
cord-290802-761wqgbe	182	2	the	the	DT
cord-290802-761wqgbe	182	3	basis	basis	NN
cord-290802-761wqgbe	182	4	of	of	IN
cord-290802-761wqgbe	182	5	these	these	DT
cord-290802-761wqgbe	182	6	RDRP−ligand	rdrp−ligand	NN
cord-290802-761wqgbe	182	7	-	-	HYPH
cord-290802-761wqgbe	182	8	binding	bind	VBG
cord-290802-761wqgbe	182	9	features	feature	NNS
cord-290802-761wqgbe	182	10	,	,	,
cord-290802-761wqgbe	182	11	multiple	multiple	JJ
cord-290802-761wqgbe	182	12	FDA	FDA	NNP
cord-290802-761wqgbe	182	13	drugs	drug	NNS
cord-290802-761wqgbe	182	14	were	be	VBD
cord-290802-761wqgbe	182	15	screened	screen	VBN
cord-290802-761wqgbe	182	16	to	to	TO
cord-290802-761wqgbe	182	17	determine	determine	VB
cord-290802-761wqgbe	182	18	possible	possible	JJ
cord-290802-761wqgbe	182	19	repurposing	repurposing	NN
cord-290802-761wqgbe	182	20	opportunities	opportunity	NNS
cord-290802-761wqgbe	182	21	.	.	.
cord-290802-761wqgbe	183	1	The	the	DT
cord-290802-761wqgbe	183	2	top-10	top-10	JJ
cord-290802-761wqgbe	183	3	speculative	speculative	JJ
cord-290802-761wqgbe	183	4	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	183	5	against	against	IN
cord-290802-761wqgbe	183	6	the	the	DT
cord-290802-761wqgbe	183	7	two	two	CD
cord-290802-761wqgbe	183	8	most	most	RBS
cord-290802-761wqgbe	183	9	distinct	distinct	JJ
cord-290802-761wqgbe	183	10	subpockets	subpocket	NNS
cord-290802-761wqgbe	183	11	are	be	VBP
cord-290802-761wqgbe	183	12	discussed	discuss	VBN
cord-290802-761wqgbe	183	13	.	.	.
cord-290802-761wqgbe	184	1	One	one	CD
cord-290802-761wqgbe	184	2	is	be	VBZ
cord-290802-761wqgbe	184	3	already	already	RB
cord-290802-761wqgbe	184	4	part	part	NN
cord-290802-761wqgbe	184	5	of	of	IN
cord-290802-761wqgbe	184	6	a	a	DT
cord-290802-761wqgbe	184	7	clinical	clinical	JJ
cord-290802-761wqgbe	184	8	trial	trial	NN
cord-290802-761wqgbe	184	9	as	as	IN
cord-290802-761wqgbe	184	10	a	a	DT
cord-290802-761wqgbe	184	11	potential	potential	JJ
cord-290802-761wqgbe	184	12	COVID-19	covid-19	CD
cord-290802-761wqgbe	184	13	drug	drug	NN
cord-290802-761wqgbe	184	14	,	,	,
cord-290802-761wqgbe	184	15	and	and	CC
cord-290802-761wqgbe	184	16	three	three	CD
cord-290802-761wqgbe	184	17	anticoagulants	anticoagulant	NNS
cord-290802-761wqgbe	184	18	are	be	VBP
cord-290802-761wqgbe	184	19	also	also	RB
cord-290802-761wqgbe	184	20	included	include	VBN
cord-290802-761wqgbe	184	21	.	.	.
cord-290802-761wqgbe	185	1	In	in	IN
cord-290802-761wqgbe	185	2	sum	sum	NN
cord-290802-761wqgbe	185	3	,	,	,
cord-290802-761wqgbe	185	4	these	these	DT
cord-290802-761wqgbe	185	5	results	result	NNS
cord-290802-761wqgbe	185	6	provide	provide	VBP
cord-290802-761wqgbe	185	7	structural	structural	JJ
cord-290802-761wqgbe	185	8	insights	insight	NNS
cord-290802-761wqgbe	185	9	into	into	IN
cord-290802-761wqgbe	185	10	targeting	target	VBG
cord-290802-761wqgbe	185	11	the	the	DT
cord-290802-761wqgbe	185	12	RDRP	RDRP	NNP
cord-290802-761wqgbe	185	13	catalytic	catalytic	JJ
cord-290802-761wqgbe	185	14	domain	domain	NN
cord-290802-761wqgbe	185	15	and	and	CC
cord-290802-761wqgbe	185	16	provide	provide	VB
cord-290802-761wqgbe	185	17	potential	potential	JJ
cord-290802-761wqgbe	185	18	repurposing	repurpose	VBG
cord-290802-761wqgbe	185	19	opportunities	opportunity	NNS
cord-290802-761wqgbe	185	20	that	that	WDT
cord-290802-761wqgbe	185	21	need	need	VBP
cord-290802-761wqgbe	185	22	experimental	experimental	JJ
cord-290802-761wqgbe	185	23	verification	verification	NN
cord-290802-761wqgbe	185	24	.	.	.
cord-290802-761wqgbe	186	1	The	the	DT
cord-290802-761wqgbe	186	2	Supporting	Supporting	NNP
cord-290802-761wqgbe	186	3	Information	Information	NNP
cord-290802-761wqgbe	186	4	is	be	VBZ
cord-290802-761wqgbe	186	5	available	available	JJ
cord-290802-761wqgbe	186	6	free	free	JJ
cord-290802-761wqgbe	186	7	of	of	IN
cord-290802-761wqgbe	186	8	charge	charge	NN
cord-290802-761wqgbe	186	9	at	at	IN
cord-290802-761wqgbe	186	10	https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00623	https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00623	NNS
cord-290802-761wqgbe	186	11	.	.	.
cord-290802-761wqgbe	187	1	(	(	-LRB-
cord-290802-761wqgbe	187	2	Table	Table	NNP
cord-290802-761wqgbe	187	3	S1	S1	NNP
cord-290802-761wqgbe	187	4	)	)	-RRB-
cord-290802-761wqgbe	187	5	,	,	,
cord-290802-761wqgbe	187	6	similarity	similarity	NN
cord-290802-761wqgbe	187	7	of	of	IN
cord-290802-761wqgbe	187	8	catalytic	catalytic	JJ
cord-290802-761wqgbe	187	9	domains	domain	NNS
cord-290802-761wqgbe	187	10	between	between	IN
cord-290802-761wqgbe	187	11	all	all	DT
cord-290802-761wqgbe	187	12	RDRPs	rdrp	NNS
cord-290802-761wqgbe	187	13	and	and	CC
cord-290802-761wqgbe	187	14	SARS	SARS	NNP
cord-290802-761wqgbe	187	15	-	-	HYPH
cord-290802-761wqgbe	187	16	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	187	17	RDRP	RDRP	NNP
cord-290802-761wqgbe	187	18	(	(	-LRB-
cord-290802-761wqgbe	187	19	Figure	figure	NN
cord-290802-761wqgbe	187	20	S1	S1	NNP
cord-290802-761wqgbe	187	21	)	)	-RRB-
cord-290802-761wqgbe	187	22	,	,	,
cord-290802-761wqgbe	187	23	RDRP	RDRP	NNP
cord-290802-761wqgbe	187	24	structure	structure	NN
cord-290802-761wqgbe	187	25	data	datum	NNS
cord-290802-761wqgbe	187	26	set	set	NN
cord-290802-761wqgbe	187	27	(	(	-LRB-
cord-290802-761wqgbe	187	28	Figure	Figure	NNP
cord-290802-761wqgbe	187	29	S2	S2	NNP
cord-290802-761wqgbe	187	30	)	)	-RRB-
cord-290802-761wqgbe	187	31	,	,	,
cord-290802-761wqgbe	187	32	and	and	CC
cord-290802-761wqgbe	187	33	two	two	CD
cord-290802-761wqgbe	187	34	subpockets	subpocket	NNS
cord-290802-761wqgbe	187	35	(	(	-LRB-
cord-290802-761wqgbe	187	36	gray	gray	JJ
cord-290802-761wqgbe	187	37	and	and	CC
cord-290802-761wqgbe	187	38	lime	lime	NN
cord-290802-761wqgbe	187	39	)	)	-RRB-
cord-290802-761wqgbe	187	40	used	use	VBD
cord-290802-761wqgbe	187	41	to	to	TO
cord-290802-761wqgbe	187	42	screen	screen	VB
cord-290802-761wqgbe	187	43	the	the	DT
cord-290802-761wqgbe	187	44	compound	compound	NN
cord-290802-761wqgbe	187	45	library	library	NN
cord-290802-761wqgbe	187	46	(	(	-LRB-
cord-290802-761wqgbe	187	47	Figure	figure	NN
cord-290802-761wqgbe	187	48	S3	s3	NN
cord-290802-761wqgbe	187	49	)	)	-RRB-
cord-290802-761wqgbe	187	50	(	(	-LRB-
cord-290802-761wqgbe	187	51	PDF	pdf	NN
cord-290802-761wqgbe	187	52	)	)	-RRB-
cord-290802-761wqgbe	188	1	The	the	DT
cord-290802-761wqgbe	188	2	complete	complete	JJ
cord-290802-761wqgbe	188	3	RDRP	rdrp	NN
cord-290802-761wqgbe	188	4	data	datum	NNS
cord-290802-761wqgbe	188	5	set	set	NN
cord-290802-761wqgbe	188	6	(	(	-LRB-
cord-290802-761wqgbe	188	7	Table	table	NN
cord-290802-761wqgbe	188	8	S2	s2	NN
cord-290802-761wqgbe	188	9	)	)	-RRB-
cord-290802-761wqgbe	189	1	(	(	-LRB-
cord-290802-761wqgbe	189	2	XLSX	XLSX	NNP
cord-290802-761wqgbe	189	3	)	)	-RRB-
cord-290802-761wqgbe	190	1	The	the	DT
cord-290802-761wqgbe	190	2	aligned	aligned	JJ
cord-290802-761wqgbe	190	3	ligand	ligand	NN
cord-290802-761wqgbe	190	4	-	-	HYPH
cord-290802-761wqgbe	190	5	binding	bind	VBG
cord-290802-761wqgbe	190	6	sites	site	NNS
cord-290802-761wqgbe	190	7	(	(	-LRB-
cord-290802-761wqgbe	190	8	Table	Table	NNP
cord-290802-761wqgbe	190	9	S3	s3	NN
cord-290802-761wqgbe	190	10	)	)	-RRB-
cord-290802-761wqgbe	190	11	(	(	-LRB-
cord-290802-761wqgbe	190	12	XLSX	XLSX	NNP
cord-290802-761wqgbe	190	13	)	)	-RRB-
cord-290802-761wqgbe	191	1	The	the	DT
cord-290802-761wqgbe	191	2	WHO	who	WP
cord-290802-761wqgbe	191	3	situation	situation	NN
cord-290802-761wqgbe	191	4	report	report	VBP
cord-290802-761wqgbe	191	5	A	a	DT
cord-290802-761wqgbe	191	6	pneumonia	pneumonia	NN
cord-290802-761wqgbe	191	7	outbreak	outbreak	NN
cord-290802-761wqgbe	191	8	associated	associate	VBN
cord-290802-761wqgbe	191	9	with	with	IN
cord-290802-761wqgbe	191	10	a	a	DT
cord-290802-761wqgbe	191	11	new	new	JJ
cord-290802-761wqgbe	191	12	coronavirus	coronavirus	NN
cord-290802-761wqgbe	191	13	of	of	IN
cord-290802-761wqgbe	191	14	probable	probable	JJ
cord-290802-761wqgbe	191	15	bat	bat	NN
cord-290802-761wqgbe	191	16	origin	origin	NN
cord-290802-761wqgbe	191	17	Research	Research	NNP
cord-290802-761wqgbe	191	18	and	and	CC
cord-290802-761wqgbe	191	19	Development	Development	NNP
cord-290802-761wqgbe	191	20	on	on	IN
cord-290802-761wqgbe	191	21	Therapeutic	therapeutic	JJ
cord-290802-761wqgbe	191	22	Agents	Agents	NNPS
cord-290802-761wqgbe	191	23	and	and	CC
cord-290802-761wqgbe	191	24	Vaccines	Vaccines	NNPS
cord-290802-761wqgbe	191	25	for	for	IN
cord-290802-761wqgbe	191	26	COVID-19	covid-19	CD
cord-290802-761wqgbe	191	27	and	and	CC
cord-290802-761wqgbe	191	28	Related	Related	NNP
cord-290802-761wqgbe	191	29	Human	Human	NNP
cord-290802-761wqgbe	191	30	Coronavirus	Coronavirus	NNP
cord-290802-761wqgbe	191	31	Diseases	Diseases	NNPS
cord-290802-761wqgbe	191	32	Vaccines	vaccine	NNS
cord-290802-761wqgbe	191	33	:	:	:
cord-290802-761wqgbe	191	34	Status	Status	NNP
cord-290802-761wqgbe	191	35	Report	Report	NNP
cord-290802-761wqgbe	191	36	Phylogenetic	Phylogenetic	NNP
cord-290802-761wqgbe	191	37	network	network	NN
cord-290802-761wqgbe	191	38	analysis	analysis	NN
cord-290802-761wqgbe	191	39	of	of	IN
cord-290802-761wqgbe	191	40	SARS	SARS	NNP
cord-290802-761wqgbe	191	41	-	-	HYPH
cord-290802-761wqgbe	191	42	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	191	43	genomes	genome	NNS
cord-290802-761wqgbe	191	44	Understanding	understand	VBG
cord-290802-761wqgbe	191	45	the	the	DT
cord-290802-761wqgbe	191	46	Latest	late	JJS
cord-290802-761wqgbe	191	47	Human	human	JJ
cord-290802-761wqgbe	191	48	Coronavirus	Coronavirus	NNP
cord-290802-761wqgbe	191	49	Threat	Threat	NNP
cord-290802-761wqgbe	191	50	.	.	.
cord-290802-761wqgbe	192	1	Viruses	virus	NNS
cord-290802-761wqgbe	192	2	Fall	fall	VBP
cord-290802-761wqgbe	192	3	,	,	,
cord-290802-761wqgbe	192	4	I.	i.	NN
cord-290802-761wqgbe	192	5	S.	S.	NNP
cord-290802-761wqgbe	192	6	Ebola	Ebola	NNP
cord-290802-761wqgbe	192	7	Virus	virus	NN
cord-290802-761wqgbe	192	8	Transmission	transmission	NN
cord-290802-761wqgbe	192	9	Caused	cause	VBN
cord-290802-761wqgbe	192	10	by	by	IN
cord-290802-761wqgbe	192	11	Persistently	persistently	RB
cord-290802-761wqgbe	192	12	Infected	infect	VBN
cord-290802-761wqgbe	192	13	Survivors	Survivors	NNPS
cord-290802-761wqgbe	192	14	of	of	IN
cord-290802-761wqgbe	192	15	the	the	DT
cord-290802-761wqgbe	192	16	2014−2016	2014−2016	JJ
cord-290802-761wqgbe	192	17	Outbreak	outbreak	NN
cord-290802-761wqgbe	192	18	in	in	IN
cord-290802-761wqgbe	192	19	West	West	NNP
cord-290802-761wqgbe	192	20	Africa	Africa	NNP
cord-290802-761wqgbe	193	1	An	an	DT
cord-290802-761wqgbe	193	2	update	update	NN
cord-290802-761wqgbe	193	3	on	on	IN
cord-290802-761wqgbe	193	4	Zika	Zika	NNP
cord-290802-761wqgbe	193	5	virus	virus	NN
cord-290802-761wqgbe	193	6	infection	infection	NN
cord-290802-761wqgbe	193	7	Drug	drug	NN
cord-290802-761wqgbe	193	8	repurposing	repurpose	VBG
cord-290802-761wqgbe	193	9	to	to	TO
cord-290802-761wqgbe	193	10	target	target	VB
cord-290802-761wqgbe	193	11	Ebola	Ebola	NNP
cord-290802-761wqgbe	193	12	virus	virus	NN
cord-290802-761wqgbe	193	13	replication	replication	NN
cord-290802-761wqgbe	193	14	and	and	CC
cord-290802-761wqgbe	193	15	virulence	virulence	NN
cord-290802-761wqgbe	193	16	using	use	VBG
cord-290802-761wqgbe	193	17	structural	structural	JJ
cord-290802-761wqgbe	193	18	systems	system	NNS
cord-290802-761wqgbe	193	19	pharmacology	pharmacology	NN
cord-290802-761wqgbe	193	20	Inhibition	Inhibition	NNP
cord-290802-761wqgbe	193	21	of	of	IN
cord-290802-761wqgbe	193	22	Influenza	Influenza	NNP
cord-290802-761wqgbe	193	23	A	A	NNP
cord-290802-761wqgbe	193	24	Virus	virus	NN
cord-290802-761wqgbe	193	25	Replication	replication	NN
cord-290802-761wqgbe	193	26	by	by	IN
cord-290802-761wqgbe	193	27	Compounds	compound	NNS
cord-290802-761wqgbe	193	28	Interfering	interfere	VBG
cord-290802-761wqgbe	193	29	with	with	IN
cord-290802-761wqgbe	193	30	the	the	DT
cord-290802-761wqgbe	193	31	Fusogenic	Fusogenic	NNP
cord-290802-761wqgbe	193	32	Function	Function	NNP
cord-290802-761wqgbe	193	33	of	of	IN
cord-290802-761wqgbe	193	34	the	the	DT
cord-290802-761wqgbe	193	35	Viral	Viral	NNP
cord-290802-761wqgbe	193	36	Hemagglutinin	Hemagglutinin	NNP
cord-290802-761wqgbe	194	1	The	the	DT
cord-290802-761wqgbe	194	2	uncoupling	uncoupling	NN
cord-290802-761wqgbe	194	3	of	of	IN
cord-290802-761wqgbe	194	4	catalysis	catalysis	NN
cord-290802-761wqgbe	194	5	and	and	CC
cord-290802-761wqgbe	194	6	translocation	translocation	NN
cord-290802-761wqgbe	194	7	in	in	IN
cord-290802-761wqgbe	194	8	the	the	DT
cord-290802-761wqgbe	194	9	viral	viral	JJ
cord-290802-761wqgbe	194	10	RNA	RNA	NNP
cord-290802-761wqgbe	194	11	-	-	HYPH
cord-290802-761wqgbe	194	12	dependent	dependent	JJ
cord-290802-761wqgbe	194	13	RNA	RNA	NNP
cord-290802-761wqgbe	194	14	polymerase	polymerase	NN
cord-290802-761wqgbe	194	15	A	a	DT
cord-290802-761wqgbe	194	16	Structural	Structural	NNP
cord-290802-761wqgbe	194	17	Overview	Overview	NNP
cord-290802-761wqgbe	194	18	of	of	IN
cord-290802-761wqgbe	194	19	RNA	RNA	NNP
cord-290802-761wqgbe	194	20	-	-	HYPH
cord-290802-761wqgbe	194	21	Dependent	Dependent	NNP
cord-290802-761wqgbe	194	22	RNA	RNA	NNP
cord-290802-761wqgbe	194	23	Polymerases	Polymerases	NNP
cord-290802-761wqgbe	194	24	from	from	IN
cord-290802-761wqgbe	194	25	the	the	DT
cord-290802-761wqgbe	194	26	Flaviviridae	Flaviviridae	NNP
cord-290802-761wqgbe	194	27	Family	Family	NNP
cord-290802-761wqgbe	194	28	Insights	Insights	NNP
cord-290802-761wqgbe	194	29	from	from	IN
cord-290802-761wqgbe	194	30	Structure	Structure	NNP
cord-290802-761wqgbe	194	31	,	,	,
cord-290802-761wqgbe	194	32	Function	Function	NNP
cord-290802-761wqgbe	194	33	and	and	CC
cord-290802-761wqgbe	194	34	Evolution	Evolution	NNP
cord-290802-761wqgbe	194	35	.	.	.
cord-290802-761wqgbe	195	1	Viruses	virus	NNS
cord-290802-761wqgbe	195	2	Structural	structural	JJ
cord-290802-761wqgbe	195	3	basis	basis	NN
cord-290802-761wqgbe	195	4	for	for	IN
cord-290802-761wqgbe	195	5	inhibition	inhibition	NN
cord-290802-761wqgbe	195	6	of	of	IN
cord-290802-761wqgbe	195	7	the	the	DT
cord-290802-761wqgbe	195	8	RNA	RNA	NNP
cord-290802-761wqgbe	195	9	-	-	HYPH
cord-290802-761wqgbe	195	10	dependent	dependent	JJ
cord-290802-761wqgbe	195	11	RNA	RNA	NNP
cord-290802-761wqgbe	195	12	polymerase	polymerase	NN
cord-290802-761wqgbe	195	13	from	from	IN
cord-290802-761wqgbe	195	14	SARS	SARS	NNP
cord-290802-761wqgbe	195	15	-	-	HYPH
cord-290802-761wqgbe	195	16	CoV-2	CoV-2	NNP
cord-290802-761wqgbe	195	17	by	by	IN
cord-290802-761wqgbe	195	18	remdesivir	remdesivir	NNP
cord-290802-761wqgbe	195	19	NIH	NIH	NNP
cord-290802-761wqgbe	195	20	clinical	clinical	JJ
cord-290802-761wqgbe	195	21	trial	trial	NN
cord-290802-761wqgbe	195	22	shows	show	VBZ
cord-290802-761wqgbe	195	23	Remdesivir	Remdesivir	NNP
cord-290802-761wqgbe	195	24	accelerates	accelerate	VBZ
cord-290802-761wqgbe	195	25	recovery	recovery	NN
cord-290802-761wqgbe	195	26	from	from	IN
cord-290802-761wqgbe	195	27	advanced	advanced	JJ
cord-290802-761wqgbe	195	28	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	195	29	Xenarios	Xenarios	NNP
cord-290802-761wqgbe	195	30	,	,	,
cord-290802-761wqgbe	195	31	I.	I.	NNP
cord-290802-761wqgbe	195	32	New	New	NNP
cord-290802-761wqgbe	195	33	and	and	CC
cord-290802-761wqgbe	195	34	continuing	continue	VBG
cord-290802-761wqgbe	195	35	developments	development	NNS
cord-290802-761wqgbe	195	36	at	at	IN
cord-290802-761wqgbe	195	37	PROSITE	PROSITE	NNP
cord-290802-761wqgbe	195	38	)	)	-RRB-
cord-290802-761wqgbe	196	1	JChem	jchem	DT
cord-290802-761wqgbe	196	2	6.2.0	6.2.0	CD
cord-290802-761wqgbe	196	3	;	;	:
cord-290802-761wqgbe	196	4	ChemAxon	ChemAxon	NNP
cord-290802-761wqgbe	196	5	Extended	extend	VBN
cord-290802-761wqgbe	196	6	-	-	HYPH
cord-290802-761wqgbe	196	7	connectivity	connectivity	NN
cord-290802-761wqgbe	196	8	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	196	9	Improving	improve	VBG
cord-290802-761wqgbe	196	10	the	the	DT
cord-290802-761wqgbe	196	11	search	search	NN
cord-290802-761wqgbe	196	12	performance	performance	NN
cord-290802-761wqgbe	196	13	of	of	IN
cord-290802-761wqgbe	196	14	extended	extended	JJ
cord-290802-761wqgbe	196	15	connectivity	connectivity	NN
cord-290802-761wqgbe	196	16	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	196	17	through	through	IN
cord-290802-761wqgbe	196	18	activityoriented	activityoriente	VBN
cord-290802-761wqgbe	196	19	feature	feature	NN
cord-290802-761wqgbe	196	20	filtering	filtering	NN
cord-290802-761wqgbe	196	21	and	and	CC
cord-290802-761wqgbe	196	22	application	application	NN
cord-290802-761wqgbe	196	23	of	of	IN
cord-290802-761wqgbe	196	24	a	a	DT
cord-290802-761wqgbe	196	25	bit	bit	NN
cord-290802-761wqgbe	196	26	-	-	HYPH
cord-290802-761wqgbe	196	27	density	density	NN
cord-290802-761wqgbe	196	28	-	-	HYPH
cord-290802-761wqgbe	196	29	dependent	dependent	JJ
cord-290802-761wqgbe	196	30	similarity	similarity	NN
cord-290802-761wqgbe	196	31	function	function	NN
cord-290802-761wqgbe	196	32	Molecular	molecular	JJ
cord-290802-761wqgbe	196	33	similarity	similarity	NN
cord-290802-761wqgbe	196	34	in	in	IN
cord-290802-761wqgbe	196	35	medicinal	medicinal	JJ
cord-290802-761wqgbe	196	36	chemistry	chemistry	NN
cord-290802-761wqgbe	196	37	Insights	insight	NNS
cord-290802-761wqgbe	196	38	into	into	IN
cord-290802-761wqgbe	196	39	the	the	DT
cord-290802-761wqgbe	196	40	binding	binding	NN
cord-290802-761wqgbe	196	41	mode	mode	NN
cord-290802-761wqgbe	196	42	of	of	IN
cord-290802-761wqgbe	196	43	MEK	MEK	NNP
cord-290802-761wqgbe	196	44	type	type	NN
cord-290802-761wqgbe	196	45	-	-	HYPH
cord-290802-761wqgbe	196	46	III	iii	CD
cord-290802-761wqgbe	196	47	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	196	48	.	.	.
cord-290802-761wqgbe	197	1	A	a	DT
cord-290802-761wqgbe	197	2	step	step	NN
cord-290802-761wqgbe	197	3	towards	towards	IN
cord-290802-761wqgbe	197	4	discovering	discover	VBG
cord-290802-761wqgbe	197	5	and	and	CC
cord-290802-761wqgbe	197	6	designing	design	VBG
cord-290802-761wqgbe	197	7	allosteric	allosteric	JJ
cord-290802-761wqgbe	197	8	kinase	kinase	NN
cord-290802-761wqgbe	197	9	inhibitors	inhibitor	NNS
cord-290802-761wqgbe	197	10	across	across	IN
cord-290802-761wqgbe	197	11	the	the	DT
cord-290802-761wqgbe	197	12	human	human	JJ
cord-290802-761wqgbe	197	13	kinome	kinome	FW
cord-290802-761wqgbe	197	14	Structural	Structural	NNP
cord-290802-761wqgbe	197	15	Insights	Insights	NNPS
cord-290802-761wqgbe	197	16	into	into	IN
cord-290802-761wqgbe	197	17	Characterizing	characterize	VBG
cord-290802-761wqgbe	197	18	Binding	Binding	NNP
cord-290802-761wqgbe	197	19	Sites	Sites	NNPS
cord-290802-761wqgbe	197	20	in	in	IN
cord-290802-761wqgbe	197	21	Epidermal	Epidermal	NNP
cord-290802-761wqgbe	197	22	Growth	Growth	NNP
cord-290802-761wqgbe	197	23	Factor	Factor	NNP
cord-290802-761wqgbe	197	24	Receptor	Receptor	NNP
cord-290802-761wqgbe	197	25	Kinase	Kinase	NNP
cord-290802-761wqgbe	197	26	Mutants	Mutants	NNPS
cord-290802-761wqgbe	197	27	Delineation	Delineation	NNP
cord-290802-761wqgbe	197	28	of	of	IN
cord-290802-761wqgbe	197	29	Polypharmacology	Polypharmacology	NNP
cord-290802-761wqgbe	197	30	across	across	IN
cord-290802-761wqgbe	197	31	the	the	DT
cord-290802-761wqgbe	197	32	Human	Human	NNP
cord-290802-761wqgbe	197	33	Structural	Structural	NNP
cord-290802-761wqgbe	197	34	Kinome	Kinome	NNP
cord-290802-761wqgbe	197	35	Using	use	VBG
cord-290802-761wqgbe	197	36	a	a	DT
cord-290802-761wqgbe	197	37	Functional	functional	JJ
cord-290802-761wqgbe	197	38	Site	Site	NNP
cord-290802-761wqgbe	197	39	Interaction	Interaction	NNP
cord-290802-761wqgbe	197	40	Fingerprint	Fingerprint	NNP
cord-290802-761wqgbe	197	41	Approach	Approach	NNP
cord-290802-761wqgbe	197	42	Revealing	reveal	VBG
cord-290802-761wqgbe	197	43	Acquired	Acquired	NNP
cord-290802-761wqgbe	197	44	Resistance	Resistance	NNP
cord-290802-761wqgbe	197	45	Mechanisms	Mechanisms	NNPS
cord-290802-761wqgbe	197	46	of	of	IN
cord-290802-761wqgbe	197	47	Kinase	Kinase	NNP
cord-290802-761wqgbe	197	48	-	-	HYPH
cord-290802-761wqgbe	197	49	Targeted	target	VBN
cord-290802-761wqgbe	197	50	Drugs	drug	NNS
cord-290802-761wqgbe	197	51	Using	use	VBG
cord-290802-761wqgbe	197	52	an	an	DT
cord-290802-761wqgbe	197	53	on	on	IN
cord-290802-761wqgbe	197	54	-	-	HYPH
cord-290802-761wqgbe	197	55	the	the	DT
cord-290802-761wqgbe	197	56	-	-	HYPH
cord-290802-761wqgbe	197	57	Fly	Fly	NNP
cord-290802-761wqgbe	197	58	,	,	,
cord-290802-761wqgbe	197	59	Function	function	NN
cord-290802-761wqgbe	197	60	-	-	HYPH
cord-290802-761wqgbe	197	61	Site	Site	NNP
cord-290802-761wqgbe	197	62	Interaction	Interaction	NNP
cord-290802-761wqgbe	197	63	Fingerprint	Fingerprint	NNP
cord-290802-761wqgbe	197	64	Approach	Approach	NNP
cord-290802-761wqgbe	197	65	A	a	DT
cord-290802-761wqgbe	197	66	robust	robust	JJ
cord-290802-761wqgbe	197	67	and	and	CC
cord-290802-761wqgbe	197	68	efficient	efficient	JJ
cord-290802-761wqgbe	197	69	algorithm	algorithm	NN
cord-290802-761wqgbe	197	70	for	for	IN
cord-290802-761wqgbe	197	71	the	the	DT
cord-290802-761wqgbe	197	72	shape	shape	NN
cord-290802-761wqgbe	197	73	description	description	NN
cord-290802-761wqgbe	197	74	of	of	IN
cord-290802-761wqgbe	197	75	protein	protein	NN
cord-290802-761wqgbe	197	76	structures	structure	NNS
cord-290802-761wqgbe	197	77	and	and	CC
cord-290802-761wqgbe	197	78	its	-PRON-	PRP$
cord-290802-761wqgbe	197	79	application	application	NN
cord-290802-761wqgbe	197	80	in	in	IN
cord-290802-761wqgbe	197	81	predicting	predict	VBG
cord-290802-761wqgbe	197	82	ligand	ligand	NN
cord-290802-761wqgbe	197	83	binding	bind	VBG
cord-290802-761wqgbe	197	84	sites	site	NNS
cord-290802-761wqgbe	197	85	Detecting	detect	VBG
cord-290802-761wqgbe	197	86	evolutionary	evolutionary	JJ
cord-290802-761wqgbe	197	87	relationships	relationship	NNS
cord-290802-761wqgbe	197	88	across	across	IN
cord-290802-761wqgbe	197	89	existing	exist	VBG
cord-290802-761wqgbe	197	90	fold	fold	JJ
cord-290802-761wqgbe	197	91	space	space	NN
cord-290802-761wqgbe	197	92	,	,	,
cord-290802-761wqgbe	197	93	using	use	VBG
cord-290802-761wqgbe	197	94	sequence	sequence	NN
cord-290802-761wqgbe	197	95	order	order	NN
cord-290802-761wqgbe	197	96	-	-	HYPH
cord-290802-761wqgbe	197	97	independent	independent	JJ
cord-290802-761wqgbe	197	98	profileprofile	profileprofile	NN
cord-290802-761wqgbe	197	99	alignments	alignment	NNS
cord-290802-761wqgbe	197	100	TM	TM	NNP
cord-290802-761wqgbe	197	101	-	-	HYPH
cord-290802-761wqgbe	197	102	align	align	NNP
cord-290802-761wqgbe	197	103	:	:	:
cord-290802-761wqgbe	197	104	a	a	DT
cord-290802-761wqgbe	197	105	protein	protein	NN
cord-290802-761wqgbe	197	106	structure	structure	NN
cord-290802-761wqgbe	197	107	alignment	alignment	NN
cord-290802-761wqgbe	197	108	algorithm	algorithm	NN
cord-290802-761wqgbe	197	109	based	base	VBN
cord-290802-761wqgbe	197	110	on	on	IN
cord-290802-761wqgbe	197	111	the	the	DT
cord-290802-761wqgbe	197	112	TM	TM	NNP
cord-290802-761wqgbe	197	113	-	-	HYPH
cord-290802-761wqgbe	197	114	score	score	NN
cord-290802-761wqgbe	197	115	Fast	fast	JJ
cord-290802-761wqgbe	197	116	protein	protein	NN
cord-290802-761wqgbe	197	117	structure	structure	NN
cord-290802-761wqgbe	197	118	alignment	alignment	NN
cord-290802-761wqgbe	197	119	using	use	VBG
cord-290802-761wqgbe	197	120	Gaussian	Gaussian	NNP
cord-290802-761wqgbe	197	121	overlap	overlap	VBP
cord-290802-761wqgbe	197	122	scoring	score	VBG
cord-290802-761wqgbe	197	123	of	of	IN
cord-290802-761wqgbe	197	124	backbone	backbone	NN
cord-290802-761wqgbe	197	125	peptide	peptide	NN
cord-290802-761wqgbe	197	126	fragment	fragment	NN
cord-290802-761wqgbe	197	127	similarity	similarity	NN
cord-290802-761wqgbe	197	128	Calculating	Calculating	NNP
cord-290802-761wqgbe	197	129	and	and	CC
cord-290802-761wqgbe	197	130	scoring	scoring	NN
cord-290802-761wqgbe	198	1	high	high	JJ
cord-290802-761wqgbe	198	2	quality	quality	NN
cord-290802-761wqgbe	198	3	multiple	multiple	JJ
cord-290802-761wqgbe	198	4	flexible	flexible	JJ
cord-290802-761wqgbe	198	5	protein	protein	NN
cord-290802-761wqgbe	198	6	structure	structure	NN
cord-290802-761wqgbe	198	7	alignments	alignment	NNS
cord-290802-761wqgbe	198	8	Structural	structural	JJ
cord-290802-761wqgbe	198	9	interaction	interaction	NN
cord-290802-761wqgbe	198	10	fingerprint	fingerprint	NN
cord-290802-761wqgbe	198	11	(	(	-LRB-
cord-290802-761wqgbe	198	12	SIFt	SIFt	NNP
cord-290802-761wqgbe	198	13	)	)	-RRB-
cord-290802-761wqgbe	198	14	:	:	:
cord-290802-761wqgbe	198	15	a	a	DT
cord-290802-761wqgbe	198	16	novel	novel	JJ
cord-290802-761wqgbe	198	17	method	method	NN
cord-290802-761wqgbe	198	18	for	for	IN
cord-290802-761wqgbe	198	19	analyzing	analyze	VBG
cord-290802-761wqgbe	198	20	three	three	CD
cord-290802-761wqgbe	198	21	-	-	HYPH
cord-290802-761wqgbe	198	22	dimensional	dimensional	JJ
cord-290802-761wqgbe	198	23	protein	protein	NN
cord-290802-761wqgbe	198	24	-	-	HYPH
cord-290802-761wqgbe	198	25	ligand	ligand	NN
cord-290802-761wqgbe	198	26	binding	binding	NN
cord-290802-761wqgbe	198	27	interactions	interaction	NNS
cord-290802-761wqgbe	198	28	Pythonbased	Pythonbased	NNP
cord-290802-761wqgbe	198	29	Protein	Protein	NNP
cord-290802-761wqgbe	198	30	-	-	HYPH
cord-290802-761wqgbe	198	31	Ligand	Ligand	NNP
cord-290802-761wqgbe	198	32	Interaction	Interaction	NNP
cord-290802-761wqgbe	198	33	Fingerprinting	fingerprinting	NN
cord-290802-761wqgbe	198	34	Optimizing	optimizing	NN
cord-290802-761wqgbe	198	35	fragment	fragment	NN
cord-290802-761wqgbe	198	36	and	and	CC
cord-290802-761wqgbe	198	37	scaffold	scaffold	NN
cord-290802-761wqgbe	198	38	docking	docking	NN
cord-290802-761wqgbe	198	39	by	by	IN
cord-290802-761wqgbe	198	40	use	use	NN
cord-290802-761wqgbe	198	41	of	of	IN
cord-290802-761wqgbe	198	42	molecular	molecular	JJ
cord-290802-761wqgbe	198	43	interaction	interaction	NN
cord-290802-761wqgbe	198	44	fingerprints	fingerprint	NNS
cord-290802-761wqgbe	199	1	sc	sc	NNP
cord-290802-761wqgbe	199	2	-	-	NNP
cord-290802-761wqgbe	199	3	PDB	PDB	NNP
cord-290802-761wqgbe	199	4	:	:	:
cord-290802-761wqgbe	199	5	an	an	DT
cord-290802-761wqgbe	199	6	annotated	annotated	JJ
cord-290802-761wqgbe	199	7	database	database	NN
cord-290802-761wqgbe	199	8	of	of	IN
cord-290802-761wqgbe	199	9	druggable	druggable	JJ
cord-290802-761wqgbe	199	10	binding	binding	NN
cord-290802-761wqgbe	199	11	sites	site	NNS
cord-290802-761wqgbe	199	12	from	from	IN
cord-290802-761wqgbe	199	13	the	the	DT
cord-290802-761wqgbe	199	14	Protein	Protein	NNP
cord-290802-761wqgbe	199	15	Data	Data	NNP
cord-290802-761wqgbe	199	16	Bank	Bank	NNP
cord-290802-761wqgbe	199	17	IChem	ichem	NN
cord-290802-761wqgbe	199	18	:	:	:
cord-290802-761wqgbe	200	1	A	a	DT
cord-290802-761wqgbe	200	2	Versatile	Versatile	NNP
cord-290802-761wqgbe	200	3	Toolkit	toolkit	NN
cord-290802-761wqgbe	200	4	for	for	IN
cord-290802-761wqgbe	200	5	Detecting	detect	VBG
cord-290802-761wqgbe	200	6	,	,	,
cord-290802-761wqgbe	200	7	Comparing	compare	VBG
cord-290802-761wqgbe	200	8	,	,	,
cord-290802-761wqgbe	200	9	and	and	CC
cord-290802-761wqgbe	200	10	Predicting	Predicting	NNP
cord-290802-761wqgbe	200	11	Protein	Protein	NNP
cord-290802-761wqgbe	200	12	-	-	HYPH
cord-290802-761wqgbe	200	13	Ligand	Ligand	NNP
cord-290802-761wqgbe	200	14	Interactions	Interactions	NNPS
cord-290802-761wqgbe	200	15	R	r	NN
cord-290802-761wqgbe	200	16	:	:	:
cord-290802-761wqgbe	201	1	A	a	DT
cord-290802-761wqgbe	201	2	language	language	NN
cord-290802-761wqgbe	201	3	and	and	CC
cord-290802-761wqgbe	201	4	environment	environment	NN
cord-290802-761wqgbe	201	5	for	for	IN
cord-290802-761wqgbe	201	6	statistical	statistical	JJ
cord-290802-761wqgbe	201	7	computing	computing	NN
cord-290802-761wqgbe	201	8	.	.	.
cord-290802-761wqgbe	202	1	R	R	NNP
cord-290802-761wqgbe	202	2	Foundation	Foundation	NNP
cord-290802-761wqgbe	202	3	for	for	IN
cord-290802-761wqgbe	202	4	Statistical	Statistical	NNP
cord-290802-761wqgbe	202	5	Computing	Computing	NNP
cord-290802-761wqgbe	202	6	DrugBank	DrugBank	NNP
cord-290802-761wqgbe	202	7	:	:	:
cord-290802-761wqgbe	203	1	a	a	DT
cord-290802-761wqgbe	203	2	knowledgebase	knowledgebase	NN
cord-290802-761wqgbe	203	3	for	for	IN
cord-290802-761wqgbe	203	4	drugs	drug	NNS
cord-290802-761wqgbe	203	5	,	,	,
cord-290802-761wqgbe	203	6	drug	drug	NN
cord-290802-761wqgbe	203	7	actions	action	NNS
cord-290802-761wqgbe	203	8	and	and	CC
cord-290802-761wqgbe	203	9	drug	drug	NN
cord-290802-761wqgbe	203	10	targets	target	NNS
cord-290802-761wqgbe	203	11	Surflex	Surflex	NNP
cord-290802-761wqgbe	203	12	-	-	HYPH
cord-290802-761wqgbe	203	13	Dock	Dock	NNP
cord-290802-761wqgbe	203	14	2.1	2.1	CD
cord-290802-761wqgbe	203	15	:	:	:
cord-290802-761wqgbe	203	16	robust	robust	JJ
cord-290802-761wqgbe	203	17	performance	performance	NN
cord-290802-761wqgbe	203	18	from	from	IN
cord-290802-761wqgbe	203	19	ligand	ligand	NN
cord-290802-761wqgbe	203	20	energetic	energetic	JJ
cord-290802-761wqgbe	203	21	modeling	modeling	NN
cord-290802-761wqgbe	203	22	,	,	,
cord-290802-761wqgbe	203	23	ring	ring	NN
cord-290802-761wqgbe	203	24	flexibility	flexibility	NN
cord-290802-761wqgbe	203	25	,	,	,
cord-290802-761wqgbe	203	26	and	and	CC
cord-290802-761wqgbe	203	27	knowledge	knowledge	NN
cord-290802-761wqgbe	203	28	-	-	HYPH
cord-290802-761wqgbe	203	29	based	base	VBN
cord-290802-761wqgbe	203	30	search	search	NN
cord-290802-761wqgbe	203	31	Surflex	Surflex	NNP
cord-290802-761wqgbe	203	32	:	:	:
cord-290802-761wqgbe	203	33	fully	fully	RB
cord-290802-761wqgbe	203	34	automatic	automatic	JJ
cord-290802-761wqgbe	203	35	flexible	flexible	JJ
cord-290802-761wqgbe	203	36	molecular	molecular	JJ
cord-290802-761wqgbe	203	37	docking	docking	NN
cord-290802-761wqgbe	203	38	using	use	VBG
cord-290802-761wqgbe	203	39	a	a	DT
cord-290802-761wqgbe	203	40	molecular	molecular	JJ
cord-290802-761wqgbe	203	41	similarity	similarity	NN
cord-290802-761wqgbe	203	42	-	-	HYPH
cord-290802-761wqgbe	203	43	based	base	VBN
cord-290802-761wqgbe	203	44	search	search	NN
cord-290802-761wqgbe	203	45	engine	engine	NN
cord-290802-761wqgbe	203	46	Scoring	score	VBG
cord-290802-761wqgbe	203	47	noncovalent	noncovalent	JJ
cord-290802-761wqgbe	203	48	protein	protein	NN
cord-290802-761wqgbe	203	49	-	-	HYPH
cord-290802-761wqgbe	203	50	ligand	ligand	NN
cord-290802-761wqgbe	203	51	interactions	interaction	NNS
cord-290802-761wqgbe	203	52	:	:	:
cord-290802-761wqgbe	203	53	a	a	DT
cord-290802-761wqgbe	203	54	continuous	continuous	JJ
cord-290802-761wqgbe	203	55	differentiable	differentiable	JJ
cord-290802-761wqgbe	203	56	function	function	NN
cord-290802-761wqgbe	203	57	tuned	tune	VBN
cord-290802-761wqgbe	203	58	to	to	TO
cord-290802-761wqgbe	203	59	compute	compute	VB
cord-290802-761wqgbe	203	60	binding	binding	JJ
cord-290802-761wqgbe	203	61	affinities	affinity	NNS
cord-290802-761wqgbe	204	1	A	a	DT
cord-290802-761wqgbe	204	2	Conserved	conserved	JJ
cord-290802-761wqgbe	204	3	Pocket	pocket	NN
cord-290802-761wqgbe	204	4	in	in	IN
cord-290802-761wqgbe	204	5	the	the	DT
cord-290802-761wqgbe	204	6	Dengue	Dengue	NNP
cord-290802-761wqgbe	204	7	Virus	virus	NN
cord-290802-761wqgbe	204	8	Polymerase	Polymerase	NNP
cord-290802-761wqgbe	204	9	Identified	identify	VBN
cord-290802-761wqgbe	204	10	through	through	IN
cord-290802-761wqgbe	204	11	Fragment	fragment	NN
cord-290802-761wqgbe	204	12	-	-	HYPH
cord-290802-761wqgbe	204	13	based	base	VBN
cord-290802-761wqgbe	204	14	Screening	Screening	NNP
cord-290802-761wqgbe	204	15	Discovery	Discovery	NNP
cord-290802-761wqgbe	204	16	of	of	IN
cord-290802-761wqgbe	204	17	a	a	DT
cord-290802-761wqgbe	204	18	potent	potent	JJ
cord-290802-761wqgbe	204	19	boronic	boronic	JJ
cord-290802-761wqgbe	204	20	acid	acid	NN
cord-290802-761wqgbe	204	21	derived	derive	VBN
cord-290802-761wqgbe	204	22	inhibitor	inhibitor	NN
cord-290802-761wqgbe	204	23	of	of	IN
cord-290802-761wqgbe	204	24	the	the	DT
cord-290802-761wqgbe	204	25	HCV	HCV	NNP
cord-290802-761wqgbe	204	26	RNA	RNA	NNP
cord-290802-761wqgbe	204	27	-	-	HYPH
cord-290802-761wqgbe	204	28	dependent	dependent	JJ
cord-290802-761wqgbe	204	29	RNA	RNA	NNP
cord-290802-761wqgbe	204	30	polymerase	polymerase	NN
cord-290802-761wqgbe	204	31	dose	dose	NN
cord-290802-761wqgbe	204	32	escalation	escalation	NN
cord-290802-761wqgbe	204	33	study	study	NN
cord-290802-761wqgbe	204	34	of	of	IN
cord-290802-761wqgbe	204	35	YM150	YM150	NNP
cord-290802-761wqgbe	204	36	,	,	,
cord-290802-761wqgbe	204	37	an	an	DT
cord-290802-761wqgbe	204	38	oral	oral	JJ
cord-290802-761wqgbe	204	39	direct	direct	JJ
cord-290802-761wqgbe	204	40	factor	factor	NN
cord-290802-761wqgbe	204	41	Xa	Xa	NNP
cord-290802-761wqgbe	204	42	inhibitor	inhibitor	NN
cord-290802-761wqgbe	204	43	,	,	,
cord-290802-761wqgbe	204	44	in	in	IN
cord-290802-761wqgbe	204	45	the	the	DT
cord-290802-761wqgbe	204	46	prevention	prevention	NN
cord-290802-761wqgbe	204	47	of	of	IN
cord-290802-761wqgbe	204	48	venous	venous	JJ
cord-290802-761wqgbe	204	49	thromboembolism	thromboembolism	NN
cord-290802-761wqgbe	204	50	in	in	IN
cord-290802-761wqgbe	204	51	elective	elective	JJ
cord-290802-761wqgbe	204	52	primary	primary	JJ
cord-290802-761wqgbe	204	53	hip	hip	NN
cord-290802-761wqgbe	204	54	replacement	replacement	NN
cord-290802-761wqgbe	204	55	surgery	surgery	NN
cord-290802-761wqgbe	204	56	Elucidating	elucidate	VBG
cord-290802-761wqgbe	204	57	the	the	DT
cord-290802-761wqgbe	204	58	mechanism	mechanism	NN
cord-290802-761wqgbe	204	59	of	of	IN
cord-290802-761wqgbe	204	60	action	action	NN
cord-290802-761wqgbe	204	61	of	of	IN
cord-290802-761wqgbe	204	62	domatinostat	domatinostat	NNP
cord-290802-761wqgbe	204	63	(	(	-LRB-
cord-290802-761wqgbe	204	64	4SC-202	4sc-202	LS
cord-290802-761wqgbe	204	65	)	)	-RRB-
cord-290802-761wqgbe	204	66	in	in	IN
cord-290802-761wqgbe	204	67	cutaneous	cutaneous	JJ
cord-290802-761wqgbe	204	68	T	T	NNP
cord-290802-761wqgbe	204	69	cell	cell	NN
cord-290802-761wqgbe	204	70	lymphoma	lymphoma	NN
cord-290802-761wqgbe	204	71	cells	cell	NNS
cord-290802-761wqgbe	204	72	CUDC-907	CUDC-907	NNP
cord-290802-761wqgbe	204	73	in	in	IN
cord-290802-761wqgbe	204	74	relapsed/	relapsed/	VBG
cord-290802-761wqgbe	204	75	refractory	refractory	JJ
cord-290802-761wqgbe	204	76	diffuse	diffuse	VBP
cord-290802-761wqgbe	204	77	large	large	JJ
cord-290802-761wqgbe	204	78	B	b	NN
cord-290802-761wqgbe	204	79	-	-	HYPH
cord-290802-761wqgbe	204	80	cell	cell	NN
cord-290802-761wqgbe	204	81	lymphoma	lymphoma	NN
cord-290802-761wqgbe	204	82	,	,	,
cord-290802-761wqgbe	204	83	including	include	VBG
cord-290802-761wqgbe	204	84	patients	patient	NNS
cord-290802-761wqgbe	204	85	with	with	IN
cord-290802-761wqgbe	204	86	MYC	MYC	NNP
cord-290802-761wqgbe	204	87	-	-	HYPH
cord-290802-761wqgbe	204	88	alterations	alteration	NNS
cord-290802-761wqgbe	204	89	:	:	:
cord-290802-761wqgbe	205	1	results	result	NNS
cord-290802-761wqgbe	205	2	from	from	IN
cord-290802-761wqgbe	205	3	an	an	DT
cord-290802-761wqgbe	205	4	expanded	expand	VBN
cord-290802-761wqgbe	205	5	phase	phase	NN
cord-290802-761wqgbe	205	6	I	-PRON-	PRP
cord-290802-761wqgbe	205	7	trial	trial	NN
cord-290802-761wqgbe	205	8	Treatment	treatment	NN
cord-290802-761wqgbe	205	9	approaches	approach	NNS
cord-290802-761wqgbe	205	10	for	for	IN
cord-290802-761wqgbe	205	11	EGFR	egfr	NN
cord-290802-761wqgbe	205	12	-	-	HYPH
cord-290802-761wqgbe	205	13	inhibitor	inhibitor	NN
cord-290802-761wqgbe	205	14	-	-	HYPH
cord-290802-761wqgbe	205	15	resistant	resistant	JJ
cord-290802-761wqgbe	205	16	patients	patient	NNS
cord-290802-761wqgbe	205	17	with	with	IN
cord-290802-761wqgbe	205	18	non	non	JJ
cord-290802-761wqgbe	205	19	-	-	JJ
cord-290802-761wqgbe	205	20	small	small	JJ
cord-290802-761wqgbe	205	21	-	-	HYPH
cord-290802-761wqgbe	205	22	cell	cell	NN
cord-290802-761wqgbe	205	23	lung	lung	NN
cord-290802-761wqgbe	205	24	cancer	cancer	NN
cord-290802-761wqgbe	205	25	A	a	DT
cord-290802-761wqgbe	205	26	phase	phase	NN
cord-290802-761wqgbe	205	27	II	ii	CD
cord-290802-761wqgbe	205	28	study	study	NN
cord-290802-761wqgbe	205	29	of	of	IN
cord-290802-761wqgbe	205	30	the	the	DT
cord-290802-761wqgbe	205	31	oral	oral	JJ
cord-290802-761wqgbe	205	32	factor	factor	NN
cord-290802-761wqgbe	205	33	Xa	Xa	NNP
cord-290802-761wqgbe	205	34	inhibitor	inhibitor	NN
cord-290802-761wqgbe	205	35	LY517717	LY517717	NNP
cord-290802-761wqgbe	205	36	for	for	IN
cord-290802-761wqgbe	205	37	the	the	DT
cord-290802-761wqgbe	205	38	prevention	prevention	NN
cord-290802-761wqgbe	205	39	of	of	IN
cord-290802-761wqgbe	205	40	venous	venous	JJ
cord-290802-761wqgbe	205	41	thromboembolism	thromboembolism	NN
cord-290802-761wqgbe	205	42	after	after	IN
cord-290802-761wqgbe	205	43	hip	hip	NN
cord-290802-761wqgbe	205	44	or	or	CC
cord-290802-761wqgbe	205	45	knee	knee	NN
cord-290802-761wqgbe	205	46	replacement	replacement	NN
cord-290802-761wqgbe	205	47	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	205	48	and	and	CC
cord-290802-761wqgbe	205	49	its	-PRON-	PRP$
cord-290802-761wqgbe	205	50	implications	implication	NNS
cord-290802-761wqgbe	205	51	for	for	IN
cord-290802-761wqgbe	205	52	thrombosis	thrombosis	NN
cord-290802-761wqgbe	205	53	and	and	CC
cord-290802-761wqgbe	205	54	anticoagulation	anticoagulation	NN
cord-290802-761wqgbe	205	55	Thromboembolism	Thromboembolism	NNP
cord-290802-761wqgbe	205	56	and	and	CC
cord-290802-761wqgbe	205	57	anticoagulant	anticoagulant	NN
cord-290802-761wqgbe	205	58	therapy	therapy	NN
cord-290802-761wqgbe	205	59	during	during	IN
cord-290802-761wqgbe	205	60	the	the	DT
cord-290802-761wqgbe	205	61	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	205	62	pandemic	pandemic	NN
cord-290802-761wqgbe	205	63	:	:	:
cord-290802-761wqgbe	205	64	interim	interim	JJ
cord-290802-761wqgbe	205	65	clinical	clinical	JJ
cord-290802-761wqgbe	205	66	guidance	guidance	NN
cord-290802-761wqgbe	205	67	from	from	IN
cord-290802-761wqgbe	205	68	the	the	DT
cord-290802-761wqgbe	205	69	anticoagulation	anticoagulation	NN
cord-290802-761wqgbe	205	70	forum	forum	NNP
cord-290802-761wqgbe	205	71	Association	Association	NNP
cord-290802-761wqgbe	205	72	of	of	IN
cord-290802-761wqgbe	205	73	Treatment	Treatment	NNP
cord-290802-761wqgbe	205	74	Dose	Dose	NNP
cord-290802-761wqgbe	205	75	Anticoagulation	Anticoagulation	NNP
cord-290802-761wqgbe	205	76	With	with	IN
cord-290802-761wqgbe	205	77	In	in	IN
cord-290802-761wqgbe	205	78	-	-	HYPH
cord-290802-761wqgbe	205	79	Hospital	Hospital	NNP
cord-290802-761wqgbe	205	80	Survival	survival	NN
cord-290802-761wqgbe	205	81	Among	among	IN
cord-290802-761wqgbe	205	82	Hospitalized	hospitalize	VBN
cord-290802-761wqgbe	205	83	Patients	Patients	NNP
cord-290802-761wqgbe	205	84	With	with	IN
cord-290802-761wqgbe	205	85	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	205	86	Trial	Trial	NNP
cord-290802-761wqgbe	205	87	Evaluating	Evaluating	NNP
cord-290802-761wqgbe	205	88	Efficacy	Efficacy	NNP
cord-290802-761wqgbe	205	89	and	and	CC
cord-290802-761wqgbe	205	90	Safety	Safety	NNP
cord-290802-761wqgbe	205	91	of	of	IN
cord-290802-761wqgbe	205	92	Anticoagulation	Anticoagulation	NNP
cord-290802-761wqgbe	205	93	in	in	IN
cord-290802-761wqgbe	205	94	Patients	Patients	NNP
cord-290802-761wqgbe	205	95	With	with	IN
cord-290802-761wqgbe	205	96	COVID-19	COVID-19	NNP
cord-290802-761wqgbe	205	97	Infection	Infection	NNP
cord-290802-761wqgbe	205	98	Repurposing	repurposing	NN
cord-290802-761wqgbe	205	99	of	of	IN
cord-290802-761wqgbe	205	100	Drugs	drug	NNS
cord-290802-761wqgbe	205	101	Is	be	VBZ
cord-290802-761wqgbe	205	102	a	a	DT
cord-290802-761wqgbe	205	103	Viable	viable	JJ
cord-290802-761wqgbe	205	104	Approach	approach	NN
cord-290802-761wqgbe	205	105	to	to	TO
cord-290802-761wqgbe	205	106	Develop	develop	VB
cord-290802-761wqgbe	205	107	Therapeutic	therapeutic	JJ
cord-290802-761wqgbe	205	108	Strategies	strategy	NNS
cord-290802-761wqgbe	205	109	against	against	IN
cord-290802-761wqgbe	205	110	Central	Central	NNP
cord-290802-761wqgbe	205	111	Nervous	Nervous	NNP
cord-290802-761wqgbe	205	112	System	System	NNP
cord-290802-761wqgbe	205	113	Related	relate	VBD
cord-290802-761wqgbe	205	114	Pathogenic	Pathogenic	NNP
cord-290802-761wqgbe	205	115	Amoebae	Amoebae	NNP
cord-290802-761wqgbe	205	116	Remdesivir	Remdesivir	NNP
cord-290802-761wqgbe	205	117	and	and	CC
cord-290802-761wqgbe	205	118	chloroquine	chloroquine	NN
cord-290802-761wqgbe	205	119	effectively	effectively	RB
cord-290802-761wqgbe	205	120	inhibit	inhibit	VBP
cord-290802-761wqgbe	205	121	the	the	DT
cord-290802-761wqgbe	205	122	recently	recently	RB
cord-290802-761wqgbe	205	123	emerged	emerge	VBN
cord-290802-761wqgbe	205	124	novel	novel	JJ
cord-290802-761wqgbe	205	125	coronavirus	coronavirus	NN
cord-290802-761wqgbe	205	126	(	(	-LRB-
cord-290802-761wqgbe	205	127	2019-nCoV	2019-ncov	CD
cord-290802-761wqgbe	205	128	)	)	-RRB-
cord-290802-761wqgbe	205	129	in	in	IN
cord-290802-761wqgbe	205	130	vitro	vitro	FW