id sid tid token lemma pos cord-309048-emmtplv3 1 1 key key JJ cord-309048-emmtplv3 1 2 : : : cord-309048-emmtplv3 1 3 cord-309048-emmtplv3 cord-309048-emmtplv3 NNS cord-309048-emmtplv3 1 4 authors author NNS cord-309048-emmtplv3 1 5 : : : cord-309048-emmtplv3 1 6 Lomonossoff Lomonossoff NNP cord-309048-emmtplv3 1 7 , , , cord-309048-emmtplv3 1 8 George George NNP cord-309048-emmtplv3 1 9 P. P. NNP cord-309048-emmtplv3 1 10 ; ; : cord-309048-emmtplv3 1 11 Wege Wege NNP cord-309048-emmtplv3 1 12 , , , cord-309048-emmtplv3 1 13 Christina Christina NNP cord-309048-emmtplv3 1 14 title title NN cord-309048-emmtplv3 1 15 : : : cord-309048-emmtplv3 1 16 TMV TMV NNP cord-309048-emmtplv3 1 17 Particles particle NNS cord-309048-emmtplv3 1 18 : : : cord-309048-emmtplv3 2 1 The the DT cord-309048-emmtplv3 2 2 Journey Journey NNP cord-309048-emmtplv3 2 3 From from IN cord-309048-emmtplv3 2 4 Fundamental Fundamental NNP cord-309048-emmtplv3 2 5 Studies Studies NNPS cord-309048-emmtplv3 2 6 to to IN cord-309048-emmtplv3 2 7 Bionanotechnology Bionanotechnology NNP cord-309048-emmtplv3 2 8 Applications Applications NNP cord-309048-emmtplv3 2 9 date date NN cord-309048-emmtplv3 2 10 : : : cord-309048-emmtplv3 2 11 2018 2018 CD cord-309048-emmtplv3 2 12 - - HYPH cord-309048-emmtplv3 2 13 07 07 CD cord-309048-emmtplv3 2 14 - - SYM cord-309048-emmtplv3 2 15 26 26 CD cord-309048-emmtplv3 2 16 journal journal NN cord-309048-emmtplv3 2 17 : : : cord-309048-emmtplv3 3 1 Adv Adv NNP cord-309048-emmtplv3 3 2 Virus virus NN cord-309048-emmtplv3 3 3 Res res NN cord-309048-emmtplv3 3 4 DOI doi NN cord-309048-emmtplv3 3 5 : : : cord-309048-emmtplv3 4 1 10.1016/ 10.1016/ CD cord-309048-emmtplv3 5 1 bs.aivir.2018.06.003 bs.aivir.2018.06.003 NNP cord-309048-emmtplv3 5 2 sha sha NNP cord-309048-emmtplv3 5 3 : : : cord-309048-emmtplv3 5 4 43caea63f88af0488b96da42e9b5ae8d978c1bf6 43caea63f88af0488b96da42e9b5ae8d978c1bf6 CD cord-309048-emmtplv3 5 5 doc_id doc_id CD cord-309048-emmtplv3 5 6 : : : cord-309048-emmtplv3 5 7 309048 309048 CD cord-309048-emmtplv3 5 8 cord_uid cord_uid NNS cord-309048-emmtplv3 5 9 : : : cord-309048-emmtplv3 5 10 emmtplv3 emmtplv3 NNP cord-309048-emmtplv3 6 1 Ever ever RB cord-309048-emmtplv3 6 2 since since IN cord-309048-emmtplv3 6 3 its -PRON- PRP$ cord-309048-emmtplv3 6 4 initial initial JJ cord-309048-emmtplv3 6 5 characterization characterization NN cord-309048-emmtplv3 6 6 in in IN cord-309048-emmtplv3 6 7 the the DT cord-309048-emmtplv3 6 8 19th 19th JJ cord-309048-emmtplv3 6 9 century century NN cord-309048-emmtplv3 6 10 , , , cord-309048-emmtplv3 6 11 tobacco tobacco NN cord-309048-emmtplv3 6 12 mosaic mosaic NN cord-309048-emmtplv3 6 13 virus virus NN cord-309048-emmtplv3 6 14 ( ( -LRB- cord-309048-emmtplv3 6 15 TMV TMV NNP cord-309048-emmtplv3 6 16 ) ) -RRB- cord-309048-emmtplv3 6 17 has have VBZ cord-309048-emmtplv3 6 18 played play VBN cord-309048-emmtplv3 6 19 a a DT cord-309048-emmtplv3 6 20 prominent prominent JJ cord-309048-emmtplv3 6 21 role role NN cord-309048-emmtplv3 6 22 in in IN cord-309048-emmtplv3 6 23 the the DT cord-309048-emmtplv3 6 24 development development NN cord-309048-emmtplv3 6 25 of of IN cord-309048-emmtplv3 6 26 modern modern JJ cord-309048-emmtplv3 6 27 virology virology NN cord-309048-emmtplv3 6 28 and and CC cord-309048-emmtplv3 6 29 molecular molecular JJ cord-309048-emmtplv3 6 30 biology biology NN cord-309048-emmtplv3 6 31 . . . cord-309048-emmtplv3 7 1 In in IN cord-309048-emmtplv3 7 2 particular particular JJ cord-309048-emmtplv3 7 3 , , , cord-309048-emmtplv3 7 4 research research NN cord-309048-emmtplv3 7 5 on on IN cord-309048-emmtplv3 7 6 the the DT cord-309048-emmtplv3 7 7 three three CD cord-309048-emmtplv3 7 8 - - HYPH cord-309048-emmtplv3 7 9 dimensional dimensional JJ cord-309048-emmtplv3 7 10 structure structure NN cord-309048-emmtplv3 7 11 of of IN cord-309048-emmtplv3 7 12 the the DT cord-309048-emmtplv3 7 13 virus virus NN cord-309048-emmtplv3 7 14 particles particle NNS cord-309048-emmtplv3 7 15 and and CC cord-309048-emmtplv3 7 16 the the DT cord-309048-emmtplv3 7 17 mechanism mechanism NN cord-309048-emmtplv3 7 18 by by IN cord-309048-emmtplv3 7 19 which which WDT cord-309048-emmtplv3 7 20 these these DT cord-309048-emmtplv3 7 21 assemble assemble VBP cord-309048-emmtplv3 7 22 from from IN cord-309048-emmtplv3 7 23 their -PRON- PRP$ cord-309048-emmtplv3 7 24 constituent constituent NN cord-309048-emmtplv3 7 25 protein protein NN cord-309048-emmtplv3 7 26 and and CC cord-309048-emmtplv3 7 27 RNA RNA NNP cord-309048-emmtplv3 7 28 components component NNS cord-309048-emmtplv3 7 29 has have VBZ cord-309048-emmtplv3 7 30 made make VBN cord-309048-emmtplv3 7 31 TMV TMV NNP cord-309048-emmtplv3 7 32 a a DT cord-309048-emmtplv3 7 33 paradigm paradigm NN cord-309048-emmtplv3 7 34 for for IN cord-309048-emmtplv3 7 35 our -PRON- PRP$ cord-309048-emmtplv3 7 36 current current JJ cord-309048-emmtplv3 7 37 view view NN cord-309048-emmtplv3 7 38 of of IN cord-309048-emmtplv3 7 39 the the DT cord-309048-emmtplv3 7 40 morphogenesis morphogenesis NN cord-309048-emmtplv3 7 41 of of IN cord-309048-emmtplv3 7 42 self self NN cord-309048-emmtplv3 7 43 - - HYPH cord-309048-emmtplv3 7 44 assembling assemble VBG cord-309048-emmtplv3 7 45 structures structure NNS cord-309048-emmtplv3 7 46 , , , cord-309048-emmtplv3 7 47 including include VBG cord-309048-emmtplv3 7 48 viral viral JJ cord-309048-emmtplv3 7 49 particles particle NNS cord-309048-emmtplv3 7 50 . . . cord-309048-emmtplv3 8 1 More more RBR cord-309048-emmtplv3 8 2 recently recently RB cord-309048-emmtplv3 8 3 , , , cord-309048-emmtplv3 8 4 this this DT cord-309048-emmtplv3 8 5 knowledge knowledge NN cord-309048-emmtplv3 8 6 has have VBZ cord-309048-emmtplv3 8 7 been be VBN cord-309048-emmtplv3 8 8 applied apply VBN cord-309048-emmtplv3 8 9 to to IN cord-309048-emmtplv3 8 10 the the DT cord-309048-emmtplv3 8 11 development development NN cord-309048-emmtplv3 8 12 of of IN cord-309048-emmtplv3 8 13 novel novel JJ cord-309048-emmtplv3 8 14 reagents reagent NNS cord-309048-emmtplv3 8 15 and and CC cord-309048-emmtplv3 8 16 structures structure NNS cord-309048-emmtplv3 8 17 for for IN cord-309048-emmtplv3 8 18 applications application NNS cord-309048-emmtplv3 8 19 in in IN cord-309048-emmtplv3 8 20 biomedicine biomedicine NN cord-309048-emmtplv3 8 21 and and CC cord-309048-emmtplv3 8 22 bionanotechnology bionanotechnology NN cord-309048-emmtplv3 8 23 . . . cord-309048-emmtplv3 9 1 In in IN cord-309048-emmtplv3 9 2 this this DT cord-309048-emmtplv3 9 3 article article NN cord-309048-emmtplv3 9 4 , , , cord-309048-emmtplv3 9 5 we -PRON- PRP cord-309048-emmtplv3 9 6 review review VBP cord-309048-emmtplv3 9 7 how how WRB cord-309048-emmtplv3 9 8 fundamental fundamental JJ cord-309048-emmtplv3 9 9 science science NN cord-309048-emmtplv3 9 10 has have VBZ cord-309048-emmtplv3 9 11 led lead VBN cord-309048-emmtplv3 9 12 to to IN cord-309048-emmtplv3 9 13 TMV TMV NNP cord-309048-emmtplv3 9 14 being be VBG cord-309048-emmtplv3 9 15 at at IN cord-309048-emmtplv3 9 16 the the DT cord-309048-emmtplv3 9 17 vanguard vanguard NN cord-309048-emmtplv3 9 18 of of IN cord-309048-emmtplv3 9 19 these these DT cord-309048-emmtplv3 9 20 new new JJ cord-309048-emmtplv3 9 21 technologies technology NNS cord-309048-emmtplv3 9 22 . . . cord-309048-emmtplv3 10 1 Tobacco tobacco NN cord-309048-emmtplv3 10 2 mosaic mosaic JJ cord-309048-emmtplv3 10 3 virus virus NN cord-309048-emmtplv3 10 4 ( ( -LRB- cord-309048-emmtplv3 10 5 TMV TMV NNP cord-309048-emmtplv3 10 6 ) ) -RRB- cord-309048-emmtplv3 10 7 has have VBZ cord-309048-emmtplv3 10 8 been be VBN cord-309048-emmtplv3 10 9 an an DT cord-309048-emmtplv3 10 10 object object NN cord-309048-emmtplv3 10 11 of of IN cord-309048-emmtplv3 10 12 intense intense JJ cord-309048-emmtplv3 10 13 scientific scientific JJ cord-309048-emmtplv3 10 14 study study NN cord-309048-emmtplv3 10 15 for for IN cord-309048-emmtplv3 10 16 more more JJR cord-309048-emmtplv3 10 17 than than IN cord-309048-emmtplv3 10 18 a a DT cord-309048-emmtplv3 10 19 century century NN cord-309048-emmtplv3 10 20 and and CC cord-309048-emmtplv3 10 21 was be VBD cord-309048-emmtplv3 10 22 the the DT cord-309048-emmtplv3 10 23 first first JJ cord-309048-emmtplv3 10 24 virus virus NN cord-309048-emmtplv3 10 25 to to TO cord-309048-emmtplv3 10 26 be be VB cord-309048-emmtplv3 10 27 so so RB cord-309048-emmtplv3 10 28 - - HYPH cord-309048-emmtplv3 10 29 named name VBN cord-309048-emmtplv3 10 30 ( ( -LRB- cord-309048-emmtplv3 10 31 Beijerinck Beijerinck NNP cord-309048-emmtplv3 10 32 , , , cord-309048-emmtplv3 10 33 1898 1898 CD cord-309048-emmtplv3 10 34 ) ) -RRB- cord-309048-emmtplv3 10 35 . . . cord-309048-emmtplv3 11 1 The the DT cord-309048-emmtplv3 11 2 fact fact NN cord-309048-emmtplv3 11 3 that that IN cord-309048-emmtplv3 11 4 it -PRON- PRP cord-309048-emmtplv3 11 5 could could MD cord-309048-emmtplv3 11 6 be be VB cord-309048-emmtplv3 11 7 propagated propagate VBN cord-309048-emmtplv3 11 8 and and CC cord-309048-emmtplv3 11 9 purified purify VBN cord-309048-emmtplv3 11 10 in in IN cord-309048-emmtplv3 11 11 large large JJ cord-309048-emmtplv3 11 12 quantities quantity NNS cord-309048-emmtplv3 11 13 led lead VBN cord-309048-emmtplv3 11 14 to to IN cord-309048-emmtplv3 11 15 TMV TMV NNP cord-309048-emmtplv3 11 16 being be VBG cord-309048-emmtplv3 11 17 at at IN cord-309048-emmtplv3 11 18 the the DT cord-309048-emmtplv3 11 19 forefront forefront NN cord-309048-emmtplv3 11 20 of of IN cord-309048-emmtplv3 11 21 developments development NNS cord-309048-emmtplv3 11 22 in in IN cord-309048-emmtplv3 11 23 modern modern JJ cord-309048-emmtplv3 11 24 virology virology NN cord-309048-emmtplv3 11 25 and and CC cord-309048-emmtplv3 11 26 molecular molecular JJ cord-309048-emmtplv3 11 27 biology biology NN cord-309048-emmtplv3 11 28 ( ( -LRB- cord-309048-emmtplv3 11 29 recently recently RB cord-309048-emmtplv3 11 30 reviewed review VBN cord-309048-emmtplv3 11 31 by by IN cord-309048-emmtplv3 11 32 Lomonossoff Lomonossoff NNP cord-309048-emmtplv3 11 33 , , , cord-309048-emmtplv3 11 34 2018 2018 CD cord-309048-emmtplv3 11 35 ) ) -RRB- cord-309048-emmtplv3 11 36 . . . cord-309048-emmtplv3 12 1 As as IN cord-309048-emmtplv3 12 2 a a DT cord-309048-emmtplv3 12 3 result result NN cord-309048-emmtplv3 12 4 of of IN cord-309048-emmtplv3 12 5 these these DT cord-309048-emmtplv3 12 6 fundamental fundamental JJ cord-309048-emmtplv3 12 7 studies study NNS cord-309048-emmtplv3 12 8 , , , cord-309048-emmtplv3 12 9 by by IN cord-309048-emmtplv3 12 10 the the DT cord-309048-emmtplv3 12 11 1980s 1980 NNS cord-309048-emmtplv3 12 12 there there EX cord-309048-emmtplv3 12 13 was be VBD cord-309048-emmtplv3 12 14 a a DT cord-309048-emmtplv3 12 15 huge huge JJ cord-309048-emmtplv3 12 16 amount amount NN cord-309048-emmtplv3 12 17 of of IN cord-309048-emmtplv3 12 18 data datum NNS cord-309048-emmtplv3 12 19 available available JJ cord-309048-emmtplv3 12 20 concerning concern VBG cord-309048-emmtplv3 12 21 both both CC cord-309048-emmtplv3 12 22 the the DT cord-309048-emmtplv3 12 23 molecular molecular JJ cord-309048-emmtplv3 12 24 genetics genetic NNS cord-309048-emmtplv3 12 25 of of IN cord-309048-emmtplv3 12 26 the the DT cord-309048-emmtplv3 12 27 virus virus NN cord-309048-emmtplv3 12 28 and and CC cord-309048-emmtplv3 12 29 the the DT cord-309048-emmtplv3 12 30 structure structure NN cord-309048-emmtplv3 12 31 of of IN cord-309048-emmtplv3 12 32 its -PRON- PRP$ cord-309048-emmtplv3 12 33 particles particle NNS cord-309048-emmtplv3 12 34 . . . cord-309048-emmtplv3 13 1 This this DT cord-309048-emmtplv3 13 2 led lead VBD cord-309048-emmtplv3 13 3 to to IN cord-309048-emmtplv3 13 4 a a DT cord-309048-emmtplv3 13 5 burgeoning burgeon VBG cord-309048-emmtplv3 13 6 interest interest NN cord-309048-emmtplv3 13 7 in in IN cord-309048-emmtplv3 13 8 the the DT cord-309048-emmtplv3 13 9 use use NN cord-309048-emmtplv3 13 10 of of IN cord-309048-emmtplv3 13 11 TMV TMV NNP cord-309048-emmtplv3 13 12 , , , cord-309048-emmtplv3 13 13 and and CC cord-309048-emmtplv3 13 14 its -PRON- PRP$ cord-309048-emmtplv3 13 15 constituent constituent JJ cord-309048-emmtplv3 13 16 parts part NNS cord-309048-emmtplv3 13 17 , , , cord-309048-emmtplv3 13 18 in in IN cord-309048-emmtplv3 13 19 bio bio NNP cord-309048-emmtplv3 13 20 - - : cord-309048-emmtplv3 13 21 and and CC cord-309048-emmtplv3 13 22 nanotechnology nanotechnology NN cord-309048-emmtplv3 13 23 . . . cord-309048-emmtplv3 14 1 Such such JJ cord-309048-emmtplv3 14 2 uses use NNS cord-309048-emmtplv3 14 3 have have VBP cord-309048-emmtplv3 14 4 included include VBN cord-309048-emmtplv3 14 5 : : : cord-309048-emmtplv3 14 6 the the DT cord-309048-emmtplv3 14 7 identification identification NN cord-309048-emmtplv3 14 8 and and CC cord-309048-emmtplv3 14 9 development development NN cord-309048-emmtplv3 14 10 of of IN cord-309048-emmtplv3 14 11 translational translational JJ cord-309048-emmtplv3 14 12 enhancers enhancer NNS cord-309048-emmtplv3 14 13 for for IN cord-309048-emmtplv3 14 14 the the DT cord-309048-emmtplv3 14 15 enhanced enhanced JJ cord-309048-emmtplv3 14 16 expression expression NN cord-309048-emmtplv3 14 17 of of IN cord-309048-emmtplv3 14 18 heterologous heterologous JJ cord-309048-emmtplv3 14 19 genes gene NNS cord-309048-emmtplv3 14 20 ( ( -LRB- cord-309048-emmtplv3 14 21 Gallie Gallie NNP cord-309048-emmtplv3 14 22 et et FW cord-309048-emmtplv3 14 23 al al NNP cord-309048-emmtplv3 14 24 . . NNP cord-309048-emmtplv3 14 25 , , , cord-309048-emmtplv3 14 26 1987a 1987a CD cord-309048-emmtplv3 14 27 ; ; : cord-309048-emmtplv3 14 28 Wilson Wilson NNP cord-309048-emmtplv3 14 29 , , , cord-309048-emmtplv3 14 30 1989 1989 CD cord-309048-emmtplv3 14 31 ) ) -RRB- cord-309048-emmtplv3 14 32 , , , cord-309048-emmtplv3 14 33 the the DT cord-309048-emmtplv3 14 34 development development NN cord-309048-emmtplv3 14 35 of of IN cord-309048-emmtplv3 14 36 efficient efficient JJ cord-309048-emmtplv3 14 37 vectors vector NNS cord-309048-emmtplv3 14 38 for for IN cord-309048-emmtplv3 14 39 transient transient JJ cord-309048-emmtplv3 14 40 expression expression NN cord-309048-emmtplv3 14 41 and and CC cord-309048-emmtplv3 14 42 virus virus NN cord-309048-emmtplv3 14 43 - - HYPH cord-309048-emmtplv3 14 44 induced induce VBN cord-309048-emmtplv3 14 45 gene gene NN cord-309048-emmtplv3 14 46 silencing silencing NN cord-309048-emmtplv3 14 47 ( ( -LRB- cord-309048-emmtplv3 14 48 VIGS VIGS NNP cord-309048-emmtplv3 14 49 ) ) -RRB- cord-309048-emmtplv3 14 50 in in IN cord-309048-emmtplv3 14 51 plants plant NNS cord-309048-emmtplv3 14 52 ( ( -LRB- cord-309048-emmtplv3 14 53 reviewed review VBN cord-309048-emmtplv3 14 54 by by IN cord-309048-emmtplv3 14 55 Peyret Peyret NNP cord-309048-emmtplv3 14 56 and and CC cord-309048-emmtplv3 14 57 Lomonossoff Lomonossoff NNP cord-309048-emmtplv3 14 58 , , , cord-309048-emmtplv3 14 59 2015 2015 CD cord-309048-emmtplv3 14 60 ) ) -RRB- cord-309048-emmtplv3 14 61 , , , cord-309048-emmtplv3 14 62 and and CC cord-309048-emmtplv3 14 63 the the DT cord-309048-emmtplv3 14 64 use use NN cord-309048-emmtplv3 14 65 of of IN cord-309048-emmtplv3 14 66 virus virus NN cord-309048-emmtplv3 14 67 - - HYPH cord-309048-emmtplv3 14 68 derived derive VBN cord-309048-emmtplv3 14 69 sequences sequence NNS cord-309048-emmtplv3 14 70 for for IN cord-309048-emmtplv3 14 71 the the DT cord-309048-emmtplv3 14 72 creation creation NN cord-309048-emmtplv3 14 73 of of IN cord-309048-emmtplv3 14 74 virus virus NN cord-309048-emmtplv3 14 75 - - HYPH cord-309048-emmtplv3 14 76 resistant resistant JJ cord-309048-emmtplv3 14 77 lines line NNS cord-309048-emmtplv3 14 78 of of IN cord-309048-emmtplv3 14 79 plants plant NNS cord-309048-emmtplv3 15 1 ( ( -LRB- cord-309048-emmtplv3 15 2 Golemboski Golemboski NNP cord-309048-emmtplv3 15 3 et et NNP cord-309048-emmtplv3 15 4 al al NNP cord-309048-emmtplv3 15 5 . . NNP cord-309048-emmtplv3 15 6 , , , cord-309048-emmtplv3 15 7 1990 1990 CD cord-309048-emmtplv3 15 8 ; ; : cord-309048-emmtplv3 15 9 Powell Powell NNP cord-309048-emmtplv3 15 10 Abel Abel NNP cord-309048-emmtplv3 15 11 et et NNP cord-309048-emmtplv3 15 12 al al NNP cord-309048-emmtplv3 15 13 . . NNP cord-309048-emmtplv3 15 14 , , , cord-309048-emmtplv3 15 15 1986 1986 CD cord-309048-emmtplv3 15 16 ) ) -RRB- cord-309048-emmtplv3 15 17 . . . cord-309048-emmtplv3 16 1 Consideration consideration NN cord-309048-emmtplv3 16 2 of of IN cord-309048-emmtplv3 16 3 all all PDT cord-309048-emmtplv3 16 4 these these DT cord-309048-emmtplv3 16 5 aspects aspect NNS cord-309048-emmtplv3 16 6 would would MD cord-309048-emmtplv3 16 7 require require VB cord-309048-emmtplv3 16 8 an an DT cord-309048-emmtplv3 16 9 extremely extremely RB cord-309048-emmtplv3 16 10 long long JJ cord-309048-emmtplv3 16 11 article article NN cord-309048-emmtplv3 16 12 , , , cord-309048-emmtplv3 16 13 possibly possibly RB cord-309048-emmtplv3 16 14 even even RB cord-309048-emmtplv3 16 15 a a DT cord-309048-emmtplv3 16 16 book book NN cord-309048-emmtplv3 16 17 . . . cord-309048-emmtplv3 17 1 Thus thus RB cord-309048-emmtplv3 17 2 , , , cord-309048-emmtplv3 17 3 this this DT cord-309048-emmtplv3 17 4 review review NN cord-309048-emmtplv3 17 5 will will MD cord-309048-emmtplv3 17 6 concentrate concentrate VB cord-309048-emmtplv3 17 7 on on IN cord-309048-emmtplv3 17 8 the the DT cord-309048-emmtplv3 17 9 contributions contribution NNS cord-309048-emmtplv3 17 10 that that WDT cord-309048-emmtplv3 17 11 TMV TMV NNP cord-309048-emmtplv3 17 12 particles particle NNS cord-309048-emmtplv3 17 13 , , , cord-309048-emmtplv3 17 14 and and CC cord-309048-emmtplv3 17 15 their -PRON- PRP$ cord-309048-emmtplv3 17 16 assembly assembly NN cord-309048-emmtplv3 17 17 properties property NNS cord-309048-emmtplv3 17 18 , , , cord-309048-emmtplv3 17 19 have have VBP cord-309048-emmtplv3 17 20 made make VBN cord-309048-emmtplv3 17 21 to to IN cord-309048-emmtplv3 17 22 bionanotechnology bionanotechnology NNP cord-309048-emmtplv3 17 23 . . . cord-309048-emmtplv3 18 1 In in IN cord-309048-emmtplv3 18 2 addition addition NN cord-309048-emmtplv3 18 3 to to IN cord-309048-emmtplv3 18 4 the the DT cord-309048-emmtplv3 18 5 ease ease NN cord-309048-emmtplv3 18 6 of of IN cord-309048-emmtplv3 18 7 its -PRON- PRP$ cord-309048-emmtplv3 18 8 propagation propagation NN cord-309048-emmtplv3 18 9 and and CC cord-309048-emmtplv3 18 10 purification purification NN cord-309048-emmtplv3 18 11 , , , cord-309048-emmtplv3 18 12 the the DT cord-309048-emmtplv3 18 13 sheer sheer JJ cord-309048-emmtplv3 18 14 simplicity simplicity NN cord-309048-emmtplv3 18 15 of of IN cord-309048-emmtplv3 18 16 its -PRON- PRP$ cord-309048-emmtplv3 18 17 genome genome NN cord-309048-emmtplv3 18 18 and and CC cord-309048-emmtplv3 18 19 particle particle NN cord-309048-emmtplv3 18 20 structure structure NN cord-309048-emmtplv3 18 21 has have VBZ cord-309048-emmtplv3 18 22 made make VBN cord-309048-emmtplv3 18 23 TMV TMV NNP cord-309048-emmtplv3 18 24 a a DT cord-309048-emmtplv3 18 25 highly highly RB cord-309048-emmtplv3 18 26 tractable tractable JJ cord-309048-emmtplv3 18 27 experimental experimental JJ cord-309048-emmtplv3 18 28 system system NN cord-309048-emmtplv3 18 29 for for IN cord-309048-emmtplv3 18 30 a a DT cord-309048-emmtplv3 18 31 number number NN cord-309048-emmtplv3 18 32 of of IN cord-309048-emmtplv3 18 33 applications application NNS cord-309048-emmtplv3 18 34 . . . cord-309048-emmtplv3 19 1 The the DT cord-309048-emmtplv3 19 2 genome genome NN cord-309048-emmtplv3 19 3 of of IN cord-309048-emmtplv3 19 4 TMV TMV NNP cord-309048-emmtplv3 19 5 consists consist VBZ cord-309048-emmtplv3 19 6 of of IN cord-309048-emmtplv3 19 7 one one CD cord-309048-emmtplv3 19 8 molecule molecule NN cord-309048-emmtplv3 19 9 of of IN cord-309048-emmtplv3 19 10 single single RB cord-309048-emmtplv3 19 11 - - HYPH cord-309048-emmtplv3 19 12 stranded stranded JJ cord-309048-emmtplv3 19 13 , , , cord-309048-emmtplv3 19 14 positive positive JJ cord-309048-emmtplv3 19 15 - - HYPH cord-309048-emmtplv3 19 16 sense sense NN cord-309048-emmtplv3 19 17 RNA RNA NNP cord-309048-emmtplv3 19 18 of of IN cord-309048-emmtplv3 19 19 6395 6395 CD cord-309048-emmtplv3 19 20 nucleotides nucleotide NNS cord-309048-emmtplv3 19 21 that that WDT cord-309048-emmtplv3 19 22 contains contain VBZ cord-309048-emmtplv3 19 23 only only RB cord-309048-emmtplv3 19 24 three three CD cord-309048-emmtplv3 19 25 open open JJ cord-309048-emmtplv3 19 26 reading reading NN cord-309048-emmtplv3 19 27 frames frame NNS cord-309048-emmtplv3 19 28 ( ( -LRB- cord-309048-emmtplv3 19 29 ORFs ORFs NNP cord-309048-emmtplv3 19 30 ; ; : cord-309048-emmtplv3 19 31 Goelet Goelet NNP cord-309048-emmtplv3 19 32 et et NNP cord-309048-emmtplv3 19 33 al al NNP cord-309048-emmtplv3 19 34 . . NNP cord-309048-emmtplv3 19 35 , , , cord-309048-emmtplv3 19 36 1982 1982 CD cord-309048-emmtplv3 19 37 ; ; . cord-309048-emmtplv3 20 1 Fig Fig NNP cord-309048-emmtplv3 20 2 . . . cord-309048-emmtplv3 20 3 1A 1a NN cord-309048-emmtplv3 20 4 ; ; : cord-309048-emmtplv3 20 5 Note note VB cord-309048-emmtplv3 20 6 : : : cord-309048-emmtplv3 20 7 All all PDT cord-309048-emmtplv3 20 8 the the DT cord-309048-emmtplv3 20 9 numbers number NNS cord-309048-emmtplv3 20 10 quoted quote VBN cord-309048-emmtplv3 20 11 here here RB cord-309048-emmtplv3 20 12 and and CC cord-309048-emmtplv3 20 13 below below IN cord-309048-emmtplv3 20 14 refer refer NN cord-309048-emmtplv3 20 15 to to IN cord-309048-emmtplv3 20 16 the the DT cord-309048-emmtplv3 20 17 U1 u1 NN cord-309048-emmtplv3 20 18 or or CC cord-309048-emmtplv3 20 19 vulgare vulgare NN cord-309048-emmtplv3 20 20 strain strain NN cord-309048-emmtplv3 20 21 of of IN cord-309048-emmtplv3 20 22 TMV TMV NNP cord-309048-emmtplv3 20 23 unless unless IN cord-309048-emmtplv3 20 24 otherwise otherwise RB cord-309048-emmtplv3 20 25 specified specify VBN cord-309048-emmtplv3 20 26 ) ) -RRB- cord-309048-emmtplv3 20 27 . . . cord-309048-emmtplv3 21 1 The the DT cord-309048-emmtplv3 21 2 5 5 CD cord-309048-emmtplv3 21 3 0 0 CD cord-309048-emmtplv3 21 4 -proximal -proximal . cord-309048-emmtplv3 22 1 ORF ORF NNP cord-309048-emmtplv3 22 2 encodes encode VBZ cord-309048-emmtplv3 22 3 the the DT cord-309048-emmtplv3 22 4 126 126 CD cord-309048-emmtplv3 22 5 and and CC cord-309048-emmtplv3 22 6 183 183 CD cord-309048-emmtplv3 22 7 kDa kDa NNS cord-309048-emmtplv3 22 8 proteins protein NNS cord-309048-emmtplv3 22 9 , , , cord-309048-emmtplv3 22 10 the the DT cord-309048-emmtplv3 22 11 longer long JJR cord-309048-emmtplv3 22 12 of of IN cord-309048-emmtplv3 22 13 which which WDT cord-309048-emmtplv3 22 14 is be VBZ cord-309048-emmtplv3 22 15 produced produce VBN cord-309048-emmtplv3 22 16 via via IN cord-309048-emmtplv3 22 17 read read NN cord-309048-emmtplv3 22 18 - - HYPH cord-309048-emmtplv3 22 19 through through NN cord-309048-emmtplv3 22 20 of of IN cord-309048-emmtplv3 22 21 a a DT cord-309048-emmtplv3 22 22 leaky leaky JJ cord-309048-emmtplv3 22 23 UAG UAG NNP cord-309048-emmtplv3 22 24 stop stop NN cord-309048-emmtplv3 22 25 codon codon NN cord-309048-emmtplv3 22 26 at at IN cord-309048-emmtplv3 22 27 the the DT cord-309048-emmtplv3 22 28 end end NN cord-309048-emmtplv3 22 29 of of IN cord-309048-emmtplv3 22 30 the the DT cord-309048-emmtplv3 22 31 126 126 CD cord-309048-emmtplv3 22 32 kDa kDa NNS cord-309048-emmtplv3 22 33 coding coding NN cord-309048-emmtplv3 22 34 sequence sequence NN cord-309048-emmtplv3 22 35 ; ; : cord-309048-emmtplv3 22 36 both both CC cord-309048-emmtplv3 22 37 these these DT cord-309048-emmtplv3 22 38 proteins protein NNS cord-309048-emmtplv3 22 39 are be VBP cord-309048-emmtplv3 22 40 translated translate VBN cord-309048-emmtplv3 22 41 from from IN cord-309048-emmtplv3 22 42 the the DT cord-309048-emmtplv3 22 43 genomic genomic JJ cord-309048-emmtplv3 22 44 RNA RNA NNP cord-309048-emmtplv3 22 45 and and CC cord-309048-emmtplv3 22 46 are be VBP cord-309048-emmtplv3 22 47 involved involve VBN cord-309048-emmtplv3 22 48 in in IN cord-309048-emmtplv3 22 49 the the DT cord-309048-emmtplv3 22 50 replication replication NN cord-309048-emmtplv3 22 51 of of IN cord-309048-emmtplv3 22 52 the the DT cord-309048-emmtplv3 22 53 viral viral JJ cord-309048-emmtplv3 22 54 RNA RNA NNP cord-309048-emmtplv3 22 55 ( ( -LRB- cord-309048-emmtplv3 22 56 Young Young NNP cord-309048-emmtplv3 22 57 et et FW cord-309048-emmtplv3 22 58 al al NNP cord-309048-emmtplv3 22 59 . . NNP cord-309048-emmtplv3 22 60 , , , cord-309048-emmtplv3 22 61 1987 1987 CD cord-309048-emmtplv3 22 62 ; ; : cord-309048-emmtplv3 22 63 Fig Fig NNP cord-309048-emmtplv3 22 64 . . . cord-309048-emmtplv3 22 65 1A 1a NN cord-309048-emmtplv3 22 66 ) ) -RRB- cord-309048-emmtplv3 22 67 . . . cord-309048-emmtplv3 23 1 To to IN cord-309048-emmtplv3 23 2 the the DT cord-309048-emmtplv3 23 3 3 3 CD cord-309048-emmtplv3 23 4 0 0 CD cord-309048-emmtplv3 23 5 side side NN cord-309048-emmtplv3 23 6 of of IN cord-309048-emmtplv3 23 7 this this DT cord-309048-emmtplv3 23 8 ORF ORF NNP cord-309048-emmtplv3 23 9 lie lie VBP cord-309048-emmtplv3 23 10 the the DT cord-309048-emmtplv3 23 11 regions region NNS cord-309048-emmtplv3 23 12 encoding encode VBG cord-309048-emmtplv3 23 13 the the DT cord-309048-emmtplv3 23 14 30 30 CD cord-309048-emmtplv3 23 15 kDa kDa NNP cord-309048-emmtplv3 23 16 viral viral JJ cord-309048-emmtplv3 23 17 movement movement NN cord-309048-emmtplv3 23 18 protein protein NN cord-309048-emmtplv3 23 19 ( ( -LRB- cord-309048-emmtplv3 23 20 MP MP NNP cord-309048-emmtplv3 23 21 ) ) -RRB- cord-309048-emmtplv3 23 22 and and CC cord-309048-emmtplv3 23 23 the the DT cord-309048-emmtplv3 23 24 17.5 17.5 CD cord-309048-emmtplv3 23 25 kDa kDa NNP cord-309048-emmtplv3 23 26 coat coat NN cord-309048-emmtplv3 23 27 protein protein NN cord-309048-emmtplv3 23 28 ( ( -LRB- cord-309048-emmtplv3 23 29 CP CP NNP cord-309048-emmtplv3 23 30 ) ) -RRB- cord-309048-emmtplv3 23 31 ; ; . cord-309048-emmtplv3 24 1 both both DT cord-309048-emmtplv3 24 2 the the DT cord-309048-emmtplv3 24 3 MP MP NNP cord-309048-emmtplv3 24 4 and and CC cord-309048-emmtplv3 24 5 CP CP NNP cord-309048-emmtplv3 24 6 are be VBP cord-309048-emmtplv3 24 7 translated translate VBN cord-309048-emmtplv3 24 8 from from IN cord-309048-emmtplv3 24 9 subgenomic subgenomic NNP cord-309048-emmtplv3 24 10 mRNAs mRNAs NNPS cord-309048-emmtplv3 25 1 ( ( -LRB- cord-309048-emmtplv3 25 2 Beachy Beachy NNP cord-309048-emmtplv3 25 3 and and CC cord-309048-emmtplv3 25 4 Zaitlin Zaitlin NNP cord-309048-emmtplv3 25 5 , , , cord-309048-emmtplv3 25 6 1977 1977 CD cord-309048-emmtplv3 25 7 ; ; : cord-309048-emmtplv3 25 8 Hunter Hunter NNP cord-309048-emmtplv3 25 9 et et NNP cord-309048-emmtplv3 25 10 al al NNP cord-309048-emmtplv3 25 11 . . NNP cord-309048-emmtplv3 25 12 , , , cord-309048-emmtplv3 25 13 1976 1976 CD cord-309048-emmtplv3 25 14 ) ) -RRB- cord-309048-emmtplv3 25 15 . . . cord-309048-emmtplv3 26 1 The the DT cord-309048-emmtplv3 26 2 genomic genomic JJ cord-309048-emmtplv3 26 3 RNA rna NN cord-309048-emmtplv3 26 4 is be VBZ cord-309048-emmtplv3 26 5 encapsidated encapsidate VBN cord-309048-emmtplv3 26 6 by by IN cord-309048-emmtplv3 26 7 approximately approximately RB cord-309048-emmtplv3 26 8 2130 2130 CD cord-309048-emmtplv3 26 9 copies copy NNS cord-309048-emmtplv3 26 10 of of IN cord-309048-emmtplv3 26 11 the the DT cord-309048-emmtplv3 26 12 CP cp NN cord-309048-emmtplv3 26 13 to to TO cord-309048-emmtplv3 26 14 give give VB cord-309048-emmtplv3 26 15 virus virus NN cord-309048-emmtplv3 26 16 particles particle NNS cord-309048-emmtplv3 26 17 with with IN cord-309048-emmtplv3 26 18 helical helical JJ cord-309048-emmtplv3 26 19 symmetry symmetry NN cord-309048-emmtplv3 26 20 . . . cord-309048-emmtplv3 27 1 The the DT cord-309048-emmtplv3 27 2 particles particle NNS cord-309048-emmtplv3 27 3 are be VBP cord-309048-emmtplv3 27 4 hollow hollow JJ cord-309048-emmtplv3 27 5 The the DT cord-309048-emmtplv3 27 6 position position NN cord-309048-emmtplv3 27 7 of of IN cord-309048-emmtplv3 27 8 the the DT cord-309048-emmtplv3 27 9 leaky leaky JJ cord-309048-emmtplv3 27 10 UAG UAG NNP cord-309048-emmtplv3 27 11 codon codon NN cord-309048-emmtplv3 27 12 within within IN cord-309048-emmtplv3 27 13 the the DT cord-309048-emmtplv3 27 14 polymerase polymerase NN cord-309048-emmtplv3 27 15 ORF ORF NNP cord-309048-emmtplv3 27 16 is be VBZ cord-309048-emmtplv3 27 17 indicated indicate VBN cord-309048-emmtplv3 27 18 . . . cord-309048-emmtplv3 28 1 The the DT cord-309048-emmtplv3 28 2 sites site NNS cord-309048-emmtplv3 28 3 for for IN cord-309048-emmtplv3 28 4 insertion insertion NN cord-309048-emmtplv3 28 5 into into IN cord-309048-emmtplv3 28 6 a a DT cord-309048-emmtplv3 28 7 surface surface NN cord-309048-emmtplv3 28 8 loop loop NN cord-309048-emmtplv3 28 9 ( ( -LRB- cord-309048-emmtplv3 28 10 L L NNP cord-309048-emmtplv3 28 11 ) ) -RRB- cord-309048-emmtplv3 28 12 and and CC cord-309048-emmtplv3 28 13 the the DT cord-309048-emmtplv3 28 14 C C NNP cord-309048-emmtplv3 28 15 - - HYPH cord-309048-emmtplv3 28 16 terminus terminus NN cord-309048-emmtplv3 28 17 ( ( -LRB- cord-309048-emmtplv3 28 18 C C NNP cord-309048-emmtplv3 28 19 ) ) -RRB- cord-309048-emmtplv3 28 20 are be VBP cord-309048-emmtplv3 28 21 shown show VBN cord-309048-emmtplv3 28 22 by by IN cord-309048-emmtplv3 28 23 red red JJ cord-309048-emmtplv3 28 24 arrows arrow NNS cord-309048-emmtplv3 28 25 above above IN cord-309048-emmtplv3 28 26 the the DT cord-309048-emmtplv3 28 27 CP CP NNP cord-309048-emmtplv3 28 28 ORF ORF NNP cord-309048-emmtplv3 28 29 . . . cord-309048-emmtplv3 29 1 ( ( -LRB- cord-309048-emmtplv3 29 2 B b NN cord-309048-emmtplv3 29 3 ) ) -RRB- cord-309048-emmtplv3 29 4 Tertiary tertiary JJ cord-309048-emmtplv3 29 5 structure structure NN cord-309048-emmtplv3 29 6 of of IN cord-309048-emmtplv3 29 7 an an DT cord-309048-emmtplv3 29 8 isolated isolated JJ cord-309048-emmtplv3 29 9 CP cp NN cord-309048-emmtplv3 29 10 subunit subunit NN cord-309048-emmtplv3 29 11 . . . cord-309048-emmtplv3 30 1 ( ( -LRB- cord-309048-emmtplv3 30 2 C C NNP cord-309048-emmtplv3 30 3 ) ) -RRB- cord-309048-emmtplv3 30 4 Structure Structure NNP cord-309048-emmtplv3 30 5 of of IN cord-309048-emmtplv3 30 6 the the DT cord-309048-emmtplv3 30 7 two two CD cord-309048-emmtplv3 30 8 - - HYPH cord-309048-emmtplv3 30 9 layer layer NN cord-309048-emmtplv3 30 10 disk disk NN cord-309048-emmtplv3 30 11 as as IN cord-309048-emmtplv3 30 12 seen see VBN cord-309048-emmtplv3 30 13 in in IN cord-309048-emmtplv3 30 14 the the DT cord-309048-emmtplv3 30 15 crystal crystal JJ cord-309048-emmtplv3 30 16 structure structure NN cord-309048-emmtplv3 30 17 of of IN cord-309048-emmtplv3 30 18 the the DT cord-309048-emmtplv3 30 19 four four CD cord-309048-emmtplv3 30 20 - - HYPH cord-309048-emmtplv3 30 21 layer layer NN cord-309048-emmtplv3 30 22 aggregate aggregate NN cord-309048-emmtplv3 30 23 described describe VBN cord-309048-emmtplv3 30 24 by by IN cord-309048-emmtplv3 30 25 Bhyravbhatla Bhyravbhatla NNP cord-309048-emmtplv3 30 26 et et NNP cord-309048-emmtplv3 30 27 al al NNP cord-309048-emmtplv3 30 28 . . . cord-309048-emmtplv3 31 1 ( ( -LRB- cord-309048-emmtplv3 31 2 1998 1998 CD cord-309048-emmtplv3 31 3 ) ) -RRB- cord-309048-emmtplv3 31 4 . . . cord-309048-emmtplv3 32 1 ( ( -LRB- cord-309048-emmtplv3 32 2 D D NNP cord-309048-emmtplv3 32 3 ) ) -RRB- cord-309048-emmtplv3 32 4 View view VB cord-309048-emmtplv3 32 5 down down RP cord-309048-emmtplv3 32 6 the the DT cord-309048-emmtplv3 32 7 assembled assemble VBN cord-309048-emmtplv3 32 8 nucleoprotein nucleoprotein NNP cord-309048-emmtplv3 32 9 helix helix NNP cord-309048-emmtplv3 32 10 . . . cord-309048-emmtplv3 33 1 ( ( -LRB- cord-309048-emmtplv3 33 2 E e NN cord-309048-emmtplv3 33 3 ) ) -RRB- cord-309048-emmtplv3 33 4 View view VB cord-309048-emmtplv3 33 5 along along IN cord-309048-emmtplv3 33 6 the the DT cord-309048-emmtplv3 33 7 TMV TMV NNP cord-309048-emmtplv3 33 8 rod rod NN cord-309048-emmtplv3 33 9 . . . cord-309048-emmtplv3 34 1 In in IN cord-309048-emmtplv3 34 2 each each DT cord-309048-emmtplv3 34 3 case case NN cord-309048-emmtplv3 34 4 the the DT cord-309048-emmtplv3 34 5 exposed expose VBN cord-309048-emmtplv3 34 6 surface surface NN cord-309048-emmtplv3 34 7 loop loop NN cord-309048-emmtplv3 34 8 and and CC cord-309048-emmtplv3 34 9 C c NN cord-309048-emmtplv3 34 10 - - HYPH cord-309048-emmtplv3 34 11 terminus terminus NN cord-309048-emmtplv3 34 12 of of IN cord-309048-emmtplv3 34 13 the the DT cord-309048-emmtplv3 34 14 CP CP NNP cord-309048-emmtplv3 34 15 are be VBP cord-309048-emmtplv3 34 16 indicated indicate VBN cord-309048-emmtplv3 34 17 in in IN cord-309048-emmtplv3 34 18 red red NN cord-309048-emmtplv3 34 19 . . . cord-309048-emmtplv3 35 1 cylinders cylinder NNS cord-309048-emmtplv3 36 1 300 300 CD cord-309048-emmtplv3 36 2 nm nm NN cord-309048-emmtplv3 36 3 in in IN cord-309048-emmtplv3 36 4 length length NN cord-309048-emmtplv3 36 5 with with IN cord-309048-emmtplv3 36 6 external external JJ cord-309048-emmtplv3 36 7 and and CC cord-309048-emmtplv3 36 8 internal internal JJ cord-309048-emmtplv3 36 9 diameters diameter NNS cord-309048-emmtplv3 36 10 of of IN cord-309048-emmtplv3 36 11 18 18 CD cord-309048-emmtplv3 36 12 and and CC cord-309048-emmtplv3 36 13 4 4 CD cord-309048-emmtplv3 36 14 nm nm NN cord-309048-emmtplv3 36 15 , , , cord-309048-emmtplv3 36 16 respectively respectively RB cord-309048-emmtplv3 36 17 . . . cord-309048-emmtplv3 37 1 The the DT cord-309048-emmtplv3 37 2 three three CD cord-309048-emmtplv3 37 3 - - HYPH cord-309048-emmtplv3 37 4 dimensional dimensional JJ cord-309048-emmtplv3 37 5 ( ( -LRB- cord-309048-emmtplv3 37 6 3D 3D NNP cord-309048-emmtplv3 37 7 ) ) -RRB- cord-309048-emmtplv3 37 8 structures structure NNS cord-309048-emmtplv3 37 9 of of IN cord-309048-emmtplv3 37 10 both both CC cord-309048-emmtplv3 37 11 the the DT cord-309048-emmtplv3 37 12 assembled assemble VBN cord-309048-emmtplv3 37 13 particles particle NNS cord-309048-emmtplv3 37 14 and and CC cord-309048-emmtplv3 37 15 the the DT cord-309048-emmtplv3 37 16 CP cp NN cord-309048-emmtplv3 37 17 subunits subunit NNS cord-309048-emmtplv3 37 18 have have VBP cord-309048-emmtplv3 37 19 been be VBN cord-309048-emmtplv3 37 20 subjected subject VBN cord-309048-emmtplv3 37 21 to to IN cord-309048-emmtplv3 37 22 detailed detailed JJ cord-309048-emmtplv3 37 23 analysis analysis NN cord-309048-emmtplv3 37 24 over over IN cord-309048-emmtplv3 37 25 many many JJ cord-309048-emmtplv3 37 26 years year NNS cord-309048-emmtplv3 37 27 by by IN cord-309048-emmtplv3 37 28 electron electron NN cord-309048-emmtplv3 37 29 microscopy microscopy NN cord-309048-emmtplv3 37 30 , , , cord-309048-emmtplv3 37 31 fiber fiber NN cord-309048-emmtplv3 37 32 diffraction diffraction NN cord-309048-emmtplv3 37 33 , , , cord-309048-emmtplv3 37 34 and and CC cord-309048-emmtplv3 37 35 X x NN cord-309048-emmtplv3 37 36 - - NN cord-309048-emmtplv3 37 37 ray ray NN cord-309048-emmtplv3 37 38 crystallography crystallography NN cord-309048-emmtplv3 37 39 . . . cord-309048-emmtplv3 38 1 These these DT cord-309048-emmtplv3 38 2 have have VBP cord-309048-emmtplv3 38 3 resulted result VBN cord-309048-emmtplv3 38 4 in in IN cord-309048-emmtplv3 38 5 an an DT cord-309048-emmtplv3 38 6 atomic atomic JJ cord-309048-emmtplv3 38 7 - - HYPH cord-309048-emmtplv3 38 8 resolution resolution NN cord-309048-emmtplv3 38 9 picture picture NN cord-309048-emmtplv3 38 10 of of IN cord-309048-emmtplv3 38 11 the the DT cord-309048-emmtplv3 38 12 viral viral JJ cord-309048-emmtplv3 38 13 particles particle NNS cord-309048-emmtplv3 38 14 and and CC cord-309048-emmtplv3 38 15 the the DT cord-309048-emmtplv3 38 16 protein protein NN cord-309048-emmtplv3 38 17 - - HYPH cord-309048-emmtplv3 38 18 protein protein NN cord-309048-emmtplv3 38 19 and and CC cord-309048-emmtplv3 38 20 protein protein NN cord-309048-emmtplv3 38 21 - - HYPH cord-309048-emmtplv3 38 22 RNA rna NN cord-309048-emmtplv3 38 23 interactions interaction NNS cord-309048-emmtplv3 38 24 that that WDT cord-309048-emmtplv3 38 25 hold hold VBP cord-309048-emmtplv3 38 26 them -PRON- PRP cord-309048-emmtplv3 38 27 together together RB cord-309048-emmtplv3 38 28 ( ( -LRB- cord-309048-emmtplv3 38 29 Bloomer Bloomer NNP cord-309048-emmtplv3 38 30 et et NNP cord-309048-emmtplv3 38 31 al al NNP cord-309048-emmtplv3 38 32 . . NNP cord-309048-emmtplv3 38 33 , , , cord-309048-emmtplv3 38 34 1978 1978 CD cord-309048-emmtplv3 38 35 ; ; : cord-309048-emmtplv3 38 36 Champness Champness NNP cord-309048-emmtplv3 38 37 et et NNP cord-309048-emmtplv3 38 38 al al NNP cord-309048-emmtplv3 38 39 . . NNP cord-309048-emmtplv3 38 40 , , , cord-309048-emmtplv3 38 41 1976 1976 CD cord-309048-emmtplv3 38 42 ; ; : cord-309048-emmtplv3 38 43 Namba Namba NNP cord-309048-emmtplv3 38 44 et et NNP cord-309048-emmtplv3 38 45 al al NNP cord-309048-emmtplv3 38 46 . . . cord-309048-emmtplv3 39 1 , , , cord-309048-emmtplv3 39 2 1989 1989 CD cord-309048-emmtplv3 39 3 ; ; : cord-309048-emmtplv3 39 4 Stubbs Stubbs NNP cord-309048-emmtplv3 39 5 et et NNP cord-309048-emmtplv3 39 6 al al NNP cord-309048-emmtplv3 39 7 . . NNP cord-309048-emmtplv3 39 8 , , , cord-309048-emmtplv3 39 9 1977 1977 CD cord-309048-emmtplv3 39 10 ) ) -RRB- cord-309048-emmtplv3 39 11 . . . cord-309048-emmtplv3 40 1 Recently recently RB cord-309048-emmtplv3 40 2 , , , cord-309048-emmtplv3 40 3 TMV TMV NNP cord-309048-emmtplv3 40 4 single single JJ cord-309048-emmtplv3 40 5 - - HYPH cord-309048-emmtplv3 40 6 particle particle NN cord-309048-emmtplv3 40 7 3D 3d JJ cord-309048-emmtplv3 40 8 reconstructions reconstruction NNS cord-309048-emmtplv3 40 9 to to IN cord-309048-emmtplv3 40 10 3.2 3.2 CD cord-309048-emmtplv3 40 11 Å å NN cord-309048-emmtplv3 40 12 resolution resolution NN cord-309048-emmtplv3 40 13 have have VBP cord-309048-emmtplv3 40 14 been be VBN cord-309048-emmtplv3 40 15 achieved achieve VBN cord-309048-emmtplv3 40 16 by by IN cord-309048-emmtplv3 40 17 cryo cryo NN cord-309048-emmtplv3 40 18 - - HYPH cord-309048-emmtplv3 40 19 electron electron NN cord-309048-emmtplv3 40 20 microscopy microscopy NN cord-309048-emmtplv3 40 21 ( ( -LRB- cord-309048-emmtplv3 40 22 cryo cryo NN cord-309048-emmtplv3 40 23 - - HYPH cord-309048-emmtplv3 40 24 EM EM NNP cord-309048-emmtplv3 40 25 ) ) -RRB- cord-309048-emmtplv3 40 26 using use VBG cord-309048-emmtplv3 40 27 direct direct JJ cord-309048-emmtplv3 40 28 electron electron NN cord-309048-emmtplv3 40 29 detectors detector NNS cord-309048-emmtplv3 40 30 confirming confirm VBG cord-309048-emmtplv3 40 31 that that IN cord-309048-emmtplv3 40 32 fiber fiber NN cord-309048-emmtplv3 40 33 diffraction diffraction NN cord-309048-emmtplv3 40 34 and and CC cord-309048-emmtplv3 40 35 cryo cryo NN cord-309048-emmtplv3 40 36 - - HYPH cord-309048-emmtplv3 40 37 EM em NN cord-309048-emmtplv3 40 38 yield yield NN cord-309048-emmtplv3 40 39 equivalent equivalent JJ cord-309048-emmtplv3 40 40 data datum NNS cord-309048-emmtplv3 40 41 ( ( -LRB- cord-309048-emmtplv3 40 42 Fromm Fromm NNP cord-309048-emmtplv3 40 43 et et NNP cord-309048-emmtplv3 40 44 al al NNP cord-309048-emmtplv3 40 45 . . NNP cord-309048-emmtplv3 40 46 , , , cord-309048-emmtplv3 40 47 2015 2015 CD cord-309048-emmtplv3 40 48 ) ) -RRB- cord-309048-emmtplv3 40 49 . . . cord-309048-emmtplv3 41 1 The the DT cord-309048-emmtplv3 41 2 CP cp NN cord-309048-emmtplv3 41 3 comprises comprise VBZ cord-309048-emmtplv3 41 4 158 158 CD cord-309048-emmtplv3 41 5 amino amino NN cord-309048-emmtplv3 41 6 acids acid NNS cord-309048-emmtplv3 41 7 and and CC cord-309048-emmtplv3 41 8 is be VBZ cord-309048-emmtplv3 41 9 wedge wedge NN cord-309048-emmtplv3 41 10 shaped shape VBN cord-309048-emmtplv3 41 11 with with IN cord-309048-emmtplv3 41 12 the the DT cord-309048-emmtplv3 41 13 wider wide JJR cord-309048-emmtplv3 41 14 end end NN cord-309048-emmtplv3 41 15 at at IN cord-309048-emmtplv3 41 16 the the DT cord-309048-emmtplv3 41 17 outer outer JJ cord-309048-emmtplv3 41 18 radius radius NN cord-309048-emmtplv3 41 19 of of IN cord-309048-emmtplv3 41 20 the the DT cord-309048-emmtplv3 41 21 virus virus NN cord-309048-emmtplv3 41 22 particle particle NN cord-309048-emmtplv3 41 23 ( ( -LRB- cord-309048-emmtplv3 41 24 Fig Fig NNP cord-309048-emmtplv3 41 25 . . . cord-309048-emmtplv3 41 26 1B 1b CD cord-309048-emmtplv3 41 27 ) ) -RRB- cord-309048-emmtplv3 41 28 . . . cord-309048-emmtplv3 42 1 Each each DT cord-309048-emmtplv3 42 2 subunit subunit NN cord-309048-emmtplv3 42 3 comprises comprise VBZ cord-309048-emmtplv3 42 4 four four CD cord-309048-emmtplv3 42 5 α α NN cord-309048-emmtplv3 42 6 - - HYPH cord-309048-emmtplv3 42 7 helices helix NNS cord-309048-emmtplv3 42 8 with with IN cord-309048-emmtplv3 42 9 both both CC cord-309048-emmtplv3 42 10 the the DT cord-309048-emmtplv3 42 11 N N NNP cord-309048-emmtplv3 42 12 - - HYPH cord-309048-emmtplv3 42 13 and and CC cord-309048-emmtplv3 42 14 C C NNP cord-309048-emmtplv3 42 15 - - HYPH cord-309048-emmtplv3 42 16 termini termini NNP cord-309048-emmtplv3 42 17 lying lie VBG cord-309048-emmtplv3 42 18 on on IN cord-309048-emmtplv3 42 19 the the DT cord-309048-emmtplv3 42 20 external external JJ cord-309048-emmtplv3 42 21 surface surface NN cord-309048-emmtplv3 42 22 of of IN cord-309048-emmtplv3 42 23 the the DT cord-309048-emmtplv3 42 24 particle particle NN cord-309048-emmtplv3 42 25 . . . cord-309048-emmtplv3 43 1 At at IN cord-309048-emmtplv3 43 2 pHs ph NNS cord-309048-emmtplv3 43 3 above above IN cord-309048-emmtplv3 43 4 neutrality neutrality NN cord-309048-emmtplv3 43 5 , , , cord-309048-emmtplv3 43 6 the the DT cord-309048-emmtplv3 43 7 isolated isolate VBN cord-309048-emmtplv3 43 8 CP cp NN cord-309048-emmtplv3 43 9 assembles assemble VBZ cord-309048-emmtplv3 43 10 into into IN cord-309048-emmtplv3 43 11 a a DT cord-309048-emmtplv3 43 12 variety variety NN cord-309048-emmtplv3 43 13 of of IN cord-309048-emmtplv3 43 14 two two CD cord-309048-emmtplv3 43 15 - - HYPH cord-309048-emmtplv3 43 16 layer layer NN cord-309048-emmtplv3 43 17 structures structure NNS cord-309048-emmtplv3 43 18 , , , cord-309048-emmtplv3 43 19 including include VBG cord-309048-emmtplv3 43 20 a a DT cord-309048-emmtplv3 43 21 disk disk NN cord-309048-emmtplv3 43 22 aggregate aggregate NN cord-309048-emmtplv3 43 23 that that WDT cord-309048-emmtplv3 43 24 has have VBZ cord-309048-emmtplv3 43 25 more more RBR cord-309048-emmtplv3 43 26 recently recently RB cord-309048-emmtplv3 43 27 been be VBN cord-309048-emmtplv3 43 28 referred refer VBN cord-309048-emmtplv3 43 29 to to IN cord-309048-emmtplv3 43 30 as as IN cord-309048-emmtplv3 43 31 a a DT cord-309048-emmtplv3 43 32 " " `` cord-309048-emmtplv3 43 33 nanoring nanoring NN cord-309048-emmtplv3 43 34 " " '' cord-309048-emmtplv3 43 35 ( ( -LRB- cord-309048-emmtplv3 43 36 Bhyravbhatla Bhyravbhatla NNP cord-309048-emmtplv3 43 37 et et NNP cord-309048-emmtplv3 43 38 al al NNP cord-309048-emmtplv3 43 39 . . NNP cord-309048-emmtplv3 43 40 , , , cord-309048-emmtplv3 43 41 1998 1998 CD cord-309048-emmtplv3 43 42 ; ; : cord-309048-emmtplv3 43 43 Bloomer Bloomer NNP cord-309048-emmtplv3 43 44 et et NNP cord-309048-emmtplv3 43 45 al al NNP cord-309048-emmtplv3 43 46 . . NNP cord-309048-emmtplv3 43 47 , , , cord-309048-emmtplv3 43 48 1978 1978 CD cord-309048-emmtplv3 43 49 ; ; : cord-309048-emmtplv3 43 50 Durham Durham NNP cord-309048-emmtplv3 43 51 et et NNP cord-309048-emmtplv3 43 52 al al NNP cord-309048-emmtplv3 43 53 . . NNP cord-309048-emmtplv3 43 54 , , , cord-309048-emmtplv3 43 55 1971 1971 CD cord-309048-emmtplv3 43 56 ; ; . cord-309048-emmtplv3 44 1 Fig Fig NNP cord-309048-emmtplv3 44 2 . . . cord-309048-emmtplv3 44 3 1C 1C NNP cord-309048-emmtplv3 44 4 ) ) -RRB- cord-309048-emmtplv3 44 5 . . . cord-309048-emmtplv3 45 1 Within within IN cord-309048-emmtplv3 45 2 the the DT cord-309048-emmtplv3 45 3 fully fully RB cord-309048-emmtplv3 45 4 assembled assemble VBN cord-309048-emmtplv3 45 5 particles particle NNS cord-309048-emmtplv3 45 6 , , , cord-309048-emmtplv3 45 7 the the DT cord-309048-emmtplv3 45 8 subunits subunit NNS cord-309048-emmtplv3 45 9 form form VBP cord-309048-emmtplv3 45 10 a a DT cord-309048-emmtplv3 45 11 right right RB cord-309048-emmtplv3 45 12 - - HYPH cord-309048-emmtplv3 45 13 handed handed JJ cord-309048-emmtplv3 45 14 helix helix NN cord-309048-emmtplv3 45 15 with with IN cord-309048-emmtplv3 45 16 a a DT cord-309048-emmtplv3 45 17 pitch pitch NN cord-309048-emmtplv3 45 18 of of IN cord-309048-emmtplv3 45 19 2.3 2.3 CD cord-309048-emmtplv3 45 20 nm nm NN cord-309048-emmtplv3 45 21 with with IN cord-309048-emmtplv3 45 22 16⅓ 16⅓ CD cord-309048-emmtplv3 45 23 subunits subunit NNS cord-309048-emmtplv3 45 24 per per IN cord-309048-emmtplv3 45 25 turn turn NN cord-309048-emmtplv3 45 26 , , , cord-309048-emmtplv3 45 27 resulting result VBG cord-309048-emmtplv3 45 28 in in IN cord-309048-emmtplv3 45 29 an an DT cord-309048-emmtplv3 45 30 average average JJ cord-309048-emmtplv3 45 31 distance distance NN cord-309048-emmtplv3 45 32 of of IN cord-309048-emmtplv3 45 33 about about RB cord-309048-emmtplv3 45 34 2.5 2.5 CD cord-309048-emmtplv3 45 35 nm nm CD cord-309048-emmtplv3 45 36 between between IN cord-309048-emmtplv3 45 37 the the DT cord-309048-emmtplv3 45 38 N N NNP cord-309048-emmtplv3 45 39 - - HYPH cord-309048-emmtplv3 45 40 or or CC cord-309048-emmtplv3 45 41 C C NNP cord-309048-emmtplv3 45 42 - - HYPH cord-309048-emmtplv3 45 43 termini termini NNP cord-309048-emmtplv3 45 44 , , , cord-309048-emmtplv3 45 45 respectively respectively RB cord-309048-emmtplv3 45 46 , , , cord-309048-emmtplv3 45 47 of of IN cord-309048-emmtplv3 45 48 adjacent adjacent JJ cord-309048-emmtplv3 45 49 CPs cp NNS cord-309048-emmtplv3 45 50 ( ( -LRB- cord-309048-emmtplv3 45 51 Fig Fig NNP cord-309048-emmtplv3 45 52 . . . cord-309048-emmtplv3 45 53 1D 1D NNP cord-309048-emmtplv3 45 54 and and CC cord-309048-emmtplv3 45 55 E E NNP cord-309048-emmtplv3 45 56 ) ) -RRB- cord-309048-emmtplv3 45 57 . . . cord-309048-emmtplv3 46 1 The the DT cord-309048-emmtplv3 46 2 RNA RNA NNP cord-309048-emmtplv3 46 3 lies lie VBZ cord-309048-emmtplv3 46 4 at at IN cord-309048-emmtplv3 46 5 a a DT cord-309048-emmtplv3 46 6 radius radius NN cord-309048-emmtplv3 46 7 of of IN cord-309048-emmtplv3 46 8 4 4 CD cord-309048-emmtplv3 46 9 nm nm NN cord-309048-emmtplv3 46 10 and and CC cord-309048-emmtplv3 46 11 three three CD cord-309048-emmtplv3 46 12 nucleotides nucleotide NNS cord-309048-emmtplv3 46 13 are be VBP cord-309048-emmtplv3 46 14 associated associate VBN cord-309048-emmtplv3 46 15 with with IN cord-309048-emmtplv3 46 16 each each DT cord-309048-emmtplv3 46 17 CP cp NN cord-309048-emmtplv3 46 18 subunit subunit NN cord-309048-emmtplv3 46 19 ( ( -LRB- cord-309048-emmtplv3 46 20 Franklin Franklin NNP cord-309048-emmtplv3 46 21 , , , cord-309048-emmtplv3 46 22 1956 1956 CD cord-309048-emmtplv3 46 23 ) ) -RRB- cord-309048-emmtplv3 46 24 . . . cord-309048-emmtplv3 47 1 The the DT cord-309048-emmtplv3 47 2 purified purify VBN cord-309048-emmtplv3 47 3 CP cp NN cord-309048-emmtplv3 47 4 forms form NNS cord-309048-emmtplv3 47 5 helical helical JJ cord-309048-emmtplv3 47 6 rods rod NNS cord-309048-emmtplv3 47 7 in in IN cord-309048-emmtplv3 47 8 the the DT cord-309048-emmtplv3 47 9 absence absence NN cord-309048-emmtplv3 47 10 of of IN cord-309048-emmtplv3 47 11 RNA RNA NNP cord-309048-emmtplv3 47 12 at at IN cord-309048-emmtplv3 47 13 pH pH NNP cord-309048-emmtplv3 47 14 less less JJR cord-309048-emmtplv3 47 15 than than IN cord-309048-emmtplv3 47 16 6.0 6.0 CD cord-309048-emmtplv3 47 17 . . . cord-309048-emmtplv3 48 1 These these DT cord-309048-emmtplv3 48 2 rods rod NNS cord-309048-emmtplv3 48 3 have have VBP cord-309048-emmtplv3 48 4 an an DT cord-309048-emmtplv3 48 5 identical identical JJ cord-309048-emmtplv3 48 6 structure structure NN cord-309048-emmtplv3 48 7 to to IN cord-309048-emmtplv3 48 8 the the DT cord-309048-emmtplv3 48 9 virus virus NN cord-309048-emmtplv3 48 10 but but CC cord-309048-emmtplv3 48 11 are be VBP cord-309048-emmtplv3 48 12 of of IN cord-309048-emmtplv3 48 13 indeterminate indeterminate JJ cord-309048-emmtplv3 48 14 length length NN cord-309048-emmtplv3 48 15 , , , cord-309048-emmtplv3 48 16 suggesting suggest VBG cord-309048-emmtplv3 48 17 that that IN cord-309048-emmtplv3 48 18 the the DT cord-309048-emmtplv3 48 19 RNA RNA NNP cord-309048-emmtplv3 48 20 effectively effectively RB cord-309048-emmtplv3 48 21 acts act VBZ cord-309048-emmtplv3 48 22 as as IN cord-309048-emmtplv3 48 23 a a DT cord-309048-emmtplv3 48 24 ruler ruler NN cord-309048-emmtplv3 48 25 that that WDT cord-309048-emmtplv3 48 26 determines determine VBZ cord-309048-emmtplv3 48 27 the the DT cord-309048-emmtplv3 48 28 particle particle NN cord-309048-emmtplv3 48 29 length length NN cord-309048-emmtplv3 48 30 . . . cord-309048-emmtplv3 49 1 In in IN cord-309048-emmtplv3 49 2 addition addition NN cord-309048-emmtplv3 49 3 to to IN cord-309048-emmtplv3 49 4 the the DT cord-309048-emmtplv3 49 5 detailed detailed JJ cord-309048-emmtplv3 49 6 structural structural JJ cord-309048-emmtplv3 49 7 information information NN cord-309048-emmtplv3 49 8 about about IN cord-309048-emmtplv3 49 9 the the DT cord-309048-emmtplv3 49 10 genome genome NN cord-309048-emmtplv3 49 11 and and CC cord-309048-emmtplv3 49 12 the the DT cord-309048-emmtplv3 49 13 virus virus NN cord-309048-emmtplv3 49 14 particles particle NNS cord-309048-emmtplv3 49 15 , , , cord-309048-emmtplv3 49 16 there there EX cord-309048-emmtplv3 49 17 is be VBZ cord-309048-emmtplv3 49 18 another another DT cord-309048-emmtplv3 49 19 feature feature NN cord-309048-emmtplv3 49 20 about about IN cord-309048-emmtplv3 49 21 TMV TMV NNP cord-309048-emmtplv3 49 22 that that WDT cord-309048-emmtplv3 49 23 has have VBZ cord-309048-emmtplv3 49 24 made make VBN cord-309048-emmtplv3 49 25 the the DT cord-309048-emmtplv3 49 26 virus virus NN cord-309048-emmtplv3 49 27 of of IN cord-309048-emmtplv3 49 28 great great JJ cord-309048-emmtplv3 49 29 interest interest NN cord-309048-emmtplv3 49 30 for for IN cord-309048-emmtplv3 49 31 potential potential JJ cord-309048-emmtplv3 49 32 applications application NNS cord-309048-emmtplv3 49 33 in in IN cord-309048-emmtplv3 49 34 bionanotechnology bionanotechnology NN cord-309048-emmtplv3 49 35 : : : cord-309048-emmtplv3 49 36 the the DT cord-309048-emmtplv3 49 37 availability availability NN cord-309048-emmtplv3 49 38 of of IN cord-309048-emmtplv3 49 39 a a DT cord-309048-emmtplv3 49 40 self self NN cord-309048-emmtplv3 49 41 - - HYPH cord-309048-emmtplv3 49 42 assembly assembly NN cord-309048-emmtplv3 49 43 system system NN cord-309048-emmtplv3 49 44 that that WDT cord-309048-emmtplv3 49 45 can can MD cord-309048-emmtplv3 49 46 operate operate VB cord-309048-emmtplv3 49 47 both both CC cord-309048-emmtplv3 49 48 in in IN cord-309048-emmtplv3 49 49 vivo vivo NN cord-309048-emmtplv3 49 50 and and CC cord-309048-emmtplv3 49 51 in in IN cord-309048-emmtplv3 49 52 vitro vitro FW cord-309048-emmtplv3 49 53 . . . cord-309048-emmtplv3 50 1 Ever ever RB cord-309048-emmtplv3 50 2 since since IN cord-309048-emmtplv3 50 3 the the DT cord-309048-emmtplv3 50 4 discovery discovery NN cord-309048-emmtplv3 50 5 that that WDT cord-309048-emmtplv3 50 6 purified purify VBD cord-309048-emmtplv3 50 7 CP CP NNP cord-309048-emmtplv3 50 8 and and CC cord-309048-emmtplv3 50 9 RNA RNA NNP cord-309048-emmtplv3 50 10 can can MD cord-309048-emmtplv3 50 11 selfassemble selfassemble VB cord-309048-emmtplv3 50 12 to to TO cord-309048-emmtplv3 50 13 produce produce VB cord-309048-emmtplv3 50 14 infectious infectious JJ cord-309048-emmtplv3 50 15 virus virus NN cord-309048-emmtplv3 50 16 particles particle NNS cord-309048-emmtplv3 50 17 in in IN cord-309048-emmtplv3 50 18 vitro vitro FW cord-309048-emmtplv3 50 19 ( ( -LRB- cord-309048-emmtplv3 50 20 Fraenkel Fraenkel NNP cord-309048-emmtplv3 50 21 - - HYPH cord-309048-emmtplv3 50 22 Conrat Conrat NNP cord-309048-emmtplv3 50 23 and and CC cord-309048-emmtplv3 50 24 Williams Williams NNP cord-309048-emmtplv3 50 25 , , , cord-309048-emmtplv3 50 26 1955 1955 CD cord-309048-emmtplv3 50 27 ) ) -RRB- cord-309048-emmtplv3 50 28 , , , cord-309048-emmtplv3 50 29 TMV TMV NNP cord-309048-emmtplv3 50 30 has have VBZ cord-309048-emmtplv3 50 31 become become VBN cord-309048-emmtplv3 50 32 a a DT cord-309048-emmtplv3 50 33 paradigm paradigm NN cord-309048-emmtplv3 50 34 for for IN cord-309048-emmtplv3 50 35 RNA rna NN cord-309048-emmtplv3 50 36 - - HYPH cord-309048-emmtplv3 50 37 protein protein NN cord-309048-emmtplv3 50 38 recognition recognition NN cord-309048-emmtplv3 50 39 . . . cord-309048-emmtplv3 51 1 In in IN cord-309048-emmtplv3 51 2 the the DT cord-309048-emmtplv3 51 3 1970s 1970 NNS cord-309048-emmtplv3 51 4 it -PRON- PRP cord-309048-emmtplv3 51 5 was be VBD cord-309048-emmtplv3 51 6 shown show VBN cord-309048-emmtplv3 51 7 that that IN cord-309048-emmtplv3 51 8 assembly assembly NN cord-309048-emmtplv3 51 9 is be VBZ cord-309048-emmtplv3 51 10 initiated initiate VBN cord-309048-emmtplv3 51 11 at at IN cord-309048-emmtplv3 51 12 a a DT cord-309048-emmtplv3 51 13 single single JJ cord-309048-emmtplv3 51 14 " " `` cord-309048-emmtplv3 51 15 origin origin NN cord-309048-emmtplv3 51 16 of of IN cord-309048-emmtplv3 51 17 assembly assembly NN cord-309048-emmtplv3 51 18 sequence sequence NN cord-309048-emmtplv3 51 19 " " '' cord-309048-emmtplv3 51 20 ( ( -LRB- cord-309048-emmtplv3 51 21 OAS OAS NNP cord-309048-emmtplv3 51 22 ) ) -RRB- cord-309048-emmtplv3 51 23 positioned position VBD cord-309048-emmtplv3 51 24 approximately approximately RB cord-309048-emmtplv3 51 25 1 1 CD cord-309048-emmtplv3 51 26 kb kb NNS cord-309048-emmtplv3 51 27 from from IN cord-309048-emmtplv3 51 28 the the DT cord-309048-emmtplv3 51 29 3 3 CD cord-309048-emmtplv3 51 30 0 0 CD cord-309048-emmtplv3 51 31 end end NN cord-309048-emmtplv3 51 32 of of IN cord-309048-emmtplv3 51 33 the the DT cord-309048-emmtplv3 51 34 genomic genomic JJ cord-309048-emmtplv3 51 35 RNA RNA NNP cord-309048-emmtplv3 51 36 ( ( -LRB- cord-309048-emmtplv3 51 37 Zimmern Zimmern NNP cord-309048-emmtplv3 51 38 , , , cord-309048-emmtplv3 51 39 1977 1977 CD cord-309048-emmtplv3 51 40 ; ; : cord-309048-emmtplv3 51 41 Zimmern Zimmern NNP cord-309048-emmtplv3 51 42 and and CC cord-309048-emmtplv3 51 43 Butler Butler NNP cord-309048-emmtplv3 51 44 , , , cord-309048-emmtplv3 51 45 1977 1977 CD cord-309048-emmtplv3 51 46 ; ; : cord-309048-emmtplv3 51 47 Zimmern Zimmern NNP cord-309048-emmtplv3 51 48 and and CC cord-309048-emmtplv3 51 49 Wilson Wilson NNP cord-309048-emmtplv3 51 50 , , , cord-309048-emmtplv3 51 51 1976 1976 CD cord-309048-emmtplv3 51 52 ) ) -RRB- cord-309048-emmtplv3 51 53 . . . cord-309048-emmtplv3 52 1 Initiation initiation NN cord-309048-emmtplv3 52 2 of of IN cord-309048-emmtplv3 52 3 the the DT cord-309048-emmtplv3 52 4 process process NN cord-309048-emmtplv3 52 5 requires require VBZ cord-309048-emmtplv3 52 6 that that IN cord-309048-emmtplv3 52 7 the the DT cord-309048-emmtplv3 52 8 CP cp NN cord-309048-emmtplv3 52 9 be be VB cord-309048-emmtplv3 52 10 in in IN cord-309048-emmtplv3 52 11 the the DT cord-309048-emmtplv3 52 12 form form NN cord-309048-emmtplv3 52 13 of of IN cord-309048-emmtplv3 52 14 a a DT cord-309048-emmtplv3 52 15 subassembly subassembly NN cord-309048-emmtplv3 52 16 , , , cord-309048-emmtplv3 52 17 consisting consist VBG cord-309048-emmtplv3 52 18 of of IN cord-309048-emmtplv3 52 19 a a DT cord-309048-emmtplv3 52 20 two two CD cord-309048-emmtplv3 52 21 - - HYPH cord-309048-emmtplv3 52 22 layer layer NN cord-309048-emmtplv3 52 23 disk disk NN cord-309048-emmtplv3 52 24 aggregate aggregate NN cord-309048-emmtplv3 52 25 , , , cord-309048-emmtplv3 52 26 rather rather RB cord-309048-emmtplv3 52 27 than than IN cord-309048-emmtplv3 52 28 individual individual JJ cord-309048-emmtplv3 52 29 subunits subunit NNS cord-309048-emmtplv3 52 30 or or CC cord-309048-emmtplv3 52 31 the the DT cord-309048-emmtplv3 52 32 helical helical JJ cord-309048-emmtplv3 52 33 aggregates aggregate NNS cord-309048-emmtplv3 52 34 that that WDT cord-309048-emmtplv3 52 35 the the DT cord-309048-emmtplv3 52 36 CP cp NN cord-309048-emmtplv3 52 37 can can MD cord-309048-emmtplv3 52 38 form form VB cord-309048-emmtplv3 52 39 under under IN cord-309048-emmtplv3 52 40 acidic acidic JJ cord-309048-emmtplv3 52 41 conditions condition NNS cord-309048-emmtplv3 52 42 ( ( -LRB- cord-309048-emmtplv3 52 43 Butler Butler NNP cord-309048-emmtplv3 52 44 and and CC cord-309048-emmtplv3 52 45 Klug Klug NNP cord-309048-emmtplv3 52 46 , , , cord-309048-emmtplv3 52 47 1971 1971 CD cord-309048-emmtplv3 52 48 ) ) -RRB- cord-309048-emmtplv3 52 49 ; ; : cord-309048-emmtplv3 52 50 the the DT cord-309048-emmtplv3 52 51 disks disk NNS cord-309048-emmtplv3 52 52 , , , cord-309048-emmtplv3 52 53 containing contain VBG cord-309048-emmtplv3 52 54 34 34 CD cord-309048-emmtplv3 52 55 CP cp NN cord-309048-emmtplv3 52 56 subunits subunit NNS cord-309048-emmtplv3 52 57 ( ( -LRB- cord-309048-emmtplv3 52 58 Fig Fig NNP cord-309048-emmtplv3 52 59 . . . cord-309048-emmtplv3 52 60 1C 1C NNP cord-309048-emmtplv3 52 61 ) ) -RRB- cord-309048-emmtplv3 52 62 , , , cord-309048-emmtplv3 52 63 interact interact VB cord-309048-emmtplv3 52 64 with with IN cord-309048-emmtplv3 52 65 a a DT cord-309048-emmtplv3 52 66 hairpin hairpin JJ cord-309048-emmtplv3 52 67 structure structure NN cord-309048-emmtplv3 52 68 formed form VBN cord-309048-emmtplv3 52 69 by by IN cord-309048-emmtplv3 52 70 the the DT cord-309048-emmtplv3 52 71 OAS OAS NNP cord-309048-emmtplv3 52 72 . . . cord-309048-emmtplv3 53 1 Assembly Assembly NNP cord-309048-emmtplv3 53 2 then then RB cord-309048-emmtplv3 53 3 proceeds proceed VBZ cord-309048-emmtplv3 53 4 bidirectionally bidirectionally RB cord-309048-emmtplv3 53 5 , , , cord-309048-emmtplv3 53 6 with with IN cord-309048-emmtplv3 53 7 assembly assembly NN cord-309048-emmtplv3 53 8 toward toward IN cord-309048-emmtplv3 53 9 the the DT cord-309048-emmtplv3 53 10 5 5 CD cord-309048-emmtplv3 53 11 0 0 CD cord-309048-emmtplv3 53 12 end end NN cord-309048-emmtplv3 53 13 of of IN cord-309048-emmtplv3 53 14 the the DT cord-309048-emmtplv3 53 15 RNA RNA NNP cord-309048-emmtplv3 53 16 being be VBG cord-309048-emmtplv3 53 17 considerably considerably RB cord-309048-emmtplv3 53 18 faster fast RBR cord-309048-emmtplv3 53 19 than than IN cord-309048-emmtplv3 53 20 that that DT cord-309048-emmtplv3 53 21 toward toward IN cord-309048-emmtplv3 53 22 the the DT cord-309048-emmtplv3 53 23 3 3 CD cord-309048-emmtplv3 53 24 0 0 CD cord-309048-emmtplv3 53 25 end end NN cord-309048-emmtplv3 53 26 . . . cord-309048-emmtplv3 54 1 This this DT cord-309048-emmtplv3 54 2 is be VBZ cord-309048-emmtplv3 54 3 due due JJ cord-309048-emmtplv3 54 4 to to IN cord-309048-emmtplv3 54 5 an an DT cord-309048-emmtplv3 54 6 asymmetric asymmetric JJ cord-309048-emmtplv3 54 7 mode mode NN cord-309048-emmtplv3 54 8 of of IN cord-309048-emmtplv3 54 9 particle particle NN cord-309048-emmtplv3 54 10 growth growth NN cord-309048-emmtplv3 54 11 : : : cord-309048-emmtplv3 54 12 further further JJ cord-309048-emmtplv3 54 13 CP cp NN cord-309048-emmtplv3 54 14 disks disk NNS cord-309048-emmtplv3 54 15 or or CC cord-309048-emmtplv3 54 16 smaller small JJR cord-309048-emmtplv3 54 17 two two CD cord-309048-emmtplv3 54 18 - - HYPH cord-309048-emmtplv3 54 19 layer layer NN cord-309048-emmtplv3 54 20 aggregates aggregate NNS cord-309048-emmtplv3 54 21 are be VBP cord-309048-emmtplv3 54 22 added add VBN cord-309048-emmtplv3 54 23 at at IN cord-309048-emmtplv3 54 24 the the DT cord-309048-emmtplv3 54 25 5 5 CD cord-309048-emmtplv3 54 26 0 0 CD cord-309048-emmtplv3 54 27 -protruding -protruding NN cord-309048-emmtplv3 54 28 traveling travel VBG cord-309048-emmtplv3 54 29 loop loop NN cord-309048-emmtplv3 54 30 of of IN cord-309048-emmtplv3 54 31 the the DT cord-309048-emmtplv3 54 32 viral viral JJ cord-309048-emmtplv3 54 33 RNA RNA NNP cord-309048-emmtplv3 54 34 ( ( -LRB- cord-309048-emmtplv3 54 35 Fig Fig NNP cord-309048-emmtplv3 54 36 . . NNP cord-309048-emmtplv3 54 37 2 2 CD cord-309048-emmtplv3 54 38 ) ) -RRB- cord-309048-emmtplv3 54 39 , , , cord-309048-emmtplv3 54 40 pulling pull VBG cord-309048-emmtplv3 54 41 the the DT cord-309048-emmtplv3 54 42 5 5 CD cord-309048-emmtplv3 54 43 0 0 CD cord-309048-emmtplv3 54 44 end end NN cord-309048-emmtplv3 54 45 the the DT cord-309048-emmtplv3 54 46 RNA RNA NNP cord-309048-emmtplv3 54 47 through through IN cord-309048-emmtplv3 54 48 the the DT cord-309048-emmtplv3 54 49 central central JJ cord-309048-emmtplv3 54 50 channel channel NN cord-309048-emmtplv3 54 51 of of IN cord-309048-emmtplv3 54 52 the the DT cord-309048-emmtplv3 54 53 nascent nascent JJ cord-309048-emmtplv3 54 54 particle particle NN cord-309048-emmtplv3 54 55 . . . cord-309048-emmtplv3 55 1 Assembly assembly NN cord-309048-emmtplv3 55 2 toward toward IN cord-309048-emmtplv3 55 3 the the DT cord-309048-emmtplv3 55 4 3 3 CD cord-309048-emmtplv3 55 5 0 0 CD cord-309048-emmtplv3 55 6 end end NN cord-309048-emmtplv3 55 7 of of IN cord-309048-emmtplv3 55 8 the the DT cord-309048-emmtplv3 55 9 RNA RNA NNP cord-309048-emmtplv3 55 10 occurs occur VBZ cord-309048-emmtplv3 55 11 through through IN cord-309048-emmtplv3 55 12 the the DT cord-309048-emmtplv3 55 13 addition addition NN cord-309048-emmtplv3 55 14 of of IN cord-309048-emmtplv3 55 15 smaller small JJR cord-309048-emmtplv3 55 16 CP cp NN cord-309048-emmtplv3 55 17 oligomers oligomer NNS cord-309048-emmtplv3 55 18 , , , cord-309048-emmtplv3 55 19 and and CC cord-309048-emmtplv3 55 20 this this DT cord-309048-emmtplv3 55 21 portion portion NN cord-309048-emmtplv3 55 22 of of IN cord-309048-emmtplv3 55 23 the the DT cord-309048-emmtplv3 55 24 RNA RNA NNP cord-309048-emmtplv3 55 25 remains remain VBZ cord-309048-emmtplv3 55 26 accessible accessible JJ cord-309048-emmtplv3 55 27 until until IN cord-309048-emmtplv3 55 28 assembly assembly NN cord-309048-emmtplv3 55 29 is be VBZ cord-309048-emmtplv3 55 30 complete complete JJ cord-309048-emmtplv3 55 31 . . . cord-309048-emmtplv3 56 1 For for IN cord-309048-emmtplv3 56 2 detailed detailed JJ cord-309048-emmtplv3 56 3 reviews review NNS cord-309048-emmtplv3 56 4 of of IN cord-309048-emmtplv3 56 5 these these DT cord-309048-emmtplv3 56 6 seminal seminal JJ cord-309048-emmtplv3 56 7 studies study NNS cord-309048-emmtplv3 56 8 on on IN cord-309048-emmtplv3 56 9 TMV TMV NNP cord-309048-emmtplv3 56 10 selfassembly selfassembly NNP cord-309048-emmtplv3 56 11 , , , cord-309048-emmtplv3 56 12 the the DT cord-309048-emmtplv3 56 13 reader reader NN cord-309048-emmtplv3 56 14 is be VBZ cord-309048-emmtplv3 56 15 referred refer VBN cord-309048-emmtplv3 56 16 to to IN cord-309048-emmtplv3 56 17 Butler Butler NNP cord-309048-emmtplv3 56 18 ( ( -LRB- cord-309048-emmtplv3 56 19 1984 1984 CD cord-309048-emmtplv3 56 20 Butler Butler NNP cord-309048-emmtplv3 56 21 ( ( -LRB- cord-309048-emmtplv3 56 22 , , , cord-309048-emmtplv3 56 23 1999 1999 CD cord-309048-emmtplv3 56 24 and and CC cord-309048-emmtplv3 56 25 Lomonossoff Lomonossoff NNP cord-309048-emmtplv3 56 26 and and CC cord-309048-emmtplv3 56 27 Wilson Wilson NNP cord-309048-emmtplv3 56 28 ( ( -LRB- cord-309048-emmtplv3 56 29 1985 1985 CD cord-309048-emmtplv3 56 30 ) ) -RRB- cord-309048-emmtplv3 56 31 . . . cord-309048-emmtplv3 57 1 In in IN cord-309048-emmtplv3 57 2 addition addition NN cord-309048-emmtplv3 57 3 to to IN cord-309048-emmtplv3 57 4 controlled control VBN cord-309048-emmtplv3 57 5 assembly assembly NN cord-309048-emmtplv3 57 6 of of IN cord-309048-emmtplv3 57 7 TMV TMV NNP cord-309048-emmtplv3 57 8 rods rod NNS cord-309048-emmtplv3 57 9 , , , cord-309048-emmtplv3 57 10 it -PRON- PRP cord-309048-emmtplv3 57 11 is be VBZ cord-309048-emmtplv3 57 12 also also RB cord-309048-emmtplv3 57 13 possible possible JJ cord-309048-emmtplv3 57 14 to to TO cord-309048-emmtplv3 57 15 sequentially sequentially RB cord-309048-emmtplv3 57 16 remove remove VB cord-309048-emmtplv3 57 17 protein protein NN cord-309048-emmtplv3 57 18 subunits subunit NNS cord-309048-emmtplv3 57 19 to to TO cord-309048-emmtplv3 57 20 expose expose VB cord-309048-emmtplv3 57 21 the the DT cord-309048-emmtplv3 57 22 5 5 CD cord-309048-emmtplv3 57 23 0 0 CD cord-309048-emmtplv3 57 24 end end NN cord-309048-emmtplv3 57 25 of of IN cord-309048-emmtplv3 57 26 the the DT cord-309048-emmtplv3 57 27 RNA RNA NNP cord-309048-emmtplv3 57 28 within within IN cord-309048-emmtplv3 57 29 rods rod NNS cord-309048-emmtplv3 57 30 by by IN cord-309048-emmtplv3 57 31 treatment treatment NN cord-309048-emmtplv3 57 32 at at IN cord-309048-emmtplv3 57 33 alkaline alkaline JJ cord-309048-emmtplv3 57 34 pH pH NNP cord-309048-emmtplv3 58 1 ( ( -LRB- cord-309048-emmtplv3 58 2 Perham Perham NNP cord-309048-emmtplv3 58 3 and and CC cord-309048-emmtplv3 58 4 Wilson Wilson NNP cord-309048-emmtplv3 58 5 , , , cord-309048-emmtplv3 58 6 1978 1978 CD cord-309048-emmtplv3 58 7 ) ) -RRB- cord-309048-emmtplv3 58 8 . . . cord-309048-emmtplv3 59 1 The the DT cord-309048-emmtplv3 59 2 processes process NNS cord-309048-emmtplv3 59 3 of of IN cord-309048-emmtplv3 59 4 controlled control VBN cord-309048-emmtplv3 59 5 nucleoprotein nucleoprotein NNP cord-309048-emmtplv3 59 6 assembly assembly NNP cord-309048-emmtplv3 59 7 and and CC cord-309048-emmtplv3 59 8 disassembly disassembly NNP cord-309048-emmtplv3 59 9 have have VBP cord-309048-emmtplv3 59 10 been be VBN cord-309048-emmtplv3 59 11 exploited exploit VBN cord-309048-emmtplv3 59 12 to to TO cord-309048-emmtplv3 59 13 generate generate VB cord-309048-emmtplv3 59 14 TMV TMV NNP cord-309048-emmtplv3 59 15 - - HYPH cord-309048-emmtplv3 59 16 derived derive VBN cord-309048-emmtplv3 59 17 nanostructures nanostructure NNS cord-309048-emmtplv3 59 18 and and CC cord-309048-emmtplv3 59 19 hybrid hybrid JJ cord-309048-emmtplv3 59 20 nanoobjects nanoobject NNS cord-309048-emmtplv3 59 21 as as IN cord-309048-emmtplv3 59 22 discussed discuss VBN cord-309048-emmtplv3 59 23 later later RB cord-309048-emmtplv3 60 1 ( ( -LRB- cord-309048-emmtplv3 60 2 Fig Fig NNP cord-309048-emmtplv3 60 3 . . NNP cord-309048-emmtplv3 60 4 2 2 CD cord-309048-emmtplv3 60 5 ) ) -RRB- cord-309048-emmtplv3 60 6 . . . cord-309048-emmtplv3 60 7 _SP cord-309048-emmtplv3 61 1 Since since IN cord-309048-emmtplv3 61 2 TMV TMV NNP cord-309048-emmtplv3 61 3 is be VBZ cord-309048-emmtplv3 61 4 mechanically mechanically RB cord-309048-emmtplv3 61 5 transmissible transmissible JJ cord-309048-emmtplv3 61 6 , , , cord-309048-emmtplv3 61 7 it -PRON- PRP cord-309048-emmtplv3 61 8 is be VBZ cord-309048-emmtplv3 61 9 very very RB cord-309048-emmtplv3 61 10 easy easy JJ cord-309048-emmtplv3 61 11 to to TO cord-309048-emmtplv3 61 12 produce produce VB cord-309048-emmtplv3 61 13 large large JJ cord-309048-emmtplv3 61 14 quantities quantity NNS cord-309048-emmtplv3 61 15 of of IN cord-309048-emmtplv3 61 16 wild wild JJ cord-309048-emmtplv3 61 17 - - HYPH cord-309048-emmtplv3 61 18 type type NN cord-309048-emmtplv3 61 19 particles particle NNS cord-309048-emmtplv3 61 20 by by IN cord-309048-emmtplv3 61 21 simply simply RB cord-309048-emmtplv3 61 22 inoculating inoculate VBG cord-309048-emmtplv3 61 23 plants plant NNS cord-309048-emmtplv3 61 24 with with IN cord-309048-emmtplv3 61 25 sap sap NN cord-309048-emmtplv3 61 26 from from IN cord-309048-emmtplv3 61 27 infected infected JJ cord-309048-emmtplv3 61 28 plants plant NNS cord-309048-emmtplv3 61 29 or or CC cord-309048-emmtplv3 61 30 with with IN cord-309048-emmtplv3 61 31 purified purify VBN cord-309048-emmtplv3 61 32 virus virus NN cord-309048-emmtplv3 61 33 . . . cord-309048-emmtplv3 62 1 However however RB cord-309048-emmtplv3 62 2 , , , cord-309048-emmtplv3 62 3 the the DT cord-309048-emmtplv3 62 4 advent advent NN cord-309048-emmtplv3 62 5 of of IN cord-309048-emmtplv3 62 6 reverse reverse JJ cord-309048-emmtplv3 62 7 genetic genetic JJ cord-309048-emmtplv3 62 8 systems system NNS cord-309048-emmtplv3 62 9 for for IN cord-309048-emmtplv3 62 10 the the DT cord-309048-emmtplv3 62 11 manipulation manipulation NN cord-309048-emmtplv3 62 12 of of IN cord-309048-emmtplv3 62 13 the the DT cord-309048-emmtplv3 62 14 TMV TMV NNP cord-309048-emmtplv3 62 15 genome genome NN cord-309048-emmtplv3 62 16 ( ( -LRB- cord-309048-emmtplv3 62 17 Dawson Dawson NNP cord-309048-emmtplv3 62 18 et et NNP cord-309048-emmtplv3 62 19 al al NNP cord-309048-emmtplv3 62 20 . . NNP cord-309048-emmtplv3 62 21 , , , cord-309048-emmtplv3 62 22 1986 1986 CD cord-309048-emmtplv3 62 23 ; ; : cord-309048-emmtplv3 62 24 Meshi Meshi NNP cord-309048-emmtplv3 62 25 et et NNP cord-309048-emmtplv3 62 26 al al NNP cord-309048-emmtplv3 62 27 . . NNP cord-309048-emmtplv3 62 28 , , , cord-309048-emmtplv3 62 29 1986 1986 CD cord-309048-emmtplv3 62 30 ) ) -RRB- cord-309048-emmtplv3 62 31 opened open VBD cord-309048-emmtplv3 62 32 up up RP cord-309048-emmtplv3 62 33 the the DT cord-309048-emmtplv3 62 34 possibility possibility NN cord-309048-emmtplv3 62 35 of of IN cord-309048-emmtplv3 62 36 genetically genetically RB cord-309048-emmtplv3 62 37 manipulating manipulate VBG cord-309048-emmtplv3 62 38 the the DT cord-309048-emmtplv3 62 39 CP cp NN cord-309048-emmtplv3 62 40 sequence sequence NN cord-309048-emmtplv3 62 41 . . . cord-309048-emmtplv3 63 1 Subsequent subsequent JJ cord-309048-emmtplv3 63 2 advances advance NNS cord-309048-emmtplv3 63 3 in in IN cord-309048-emmtplv3 63 4 the the DT cord-309048-emmtplv3 63 5 technology technology NN cord-309048-emmtplv3 63 6 for for IN cord-309048-emmtplv3 63 7 efficiently efficiently RB cord-309048-emmtplv3 63 8 initiating initiate VBG cord-309048-emmtplv3 63 9 infections infection NNS cord-309048-emmtplv3 63 10 , , , cord-309048-emmtplv3 63 11 such such JJ cord-309048-emmtplv3 63 12 as as IN cord-309048-emmtplv3 63 13 the the DT cord-309048-emmtplv3 63 14 use use NN cord-309048-emmtplv3 63 15 of of IN cord-309048-emmtplv3 63 16 agroinfiltration agroinfiltration NN cord-309048-emmtplv3 63 17 ( ( -LRB- cord-309048-emmtplv3 63 18 Lindbo Lindbo NNP cord-309048-emmtplv3 63 19 , , , cord-309048-emmtplv3 63 20 2007 2007 CD cord-309048-emmtplv3 63 21 ; ; : cord-309048-emmtplv3 63 22 Marillonnet Marillonnet NNP cord-309048-emmtplv3 63 23 et et NNP cord-309048-emmtplv3 63 24 al al NNP cord-309048-emmtplv3 63 25 . . NNP cord-309048-emmtplv3 63 26 , , , cord-309048-emmtplv3 63 27 2004 2004 CD cord-309048-emmtplv3 63 28 ) ) -RRB- cord-309048-emmtplv3 63 29 or or CC cord-309048-emmtplv3 63 30 the the DT cord-309048-emmtplv3 63 31 use use NN cord-309048-emmtplv3 63 32 of of IN cord-309048-emmtplv3 63 33 plant plant NN cord-309048-emmtplv3 63 34 - - HYPH cord-309048-emmtplv3 63 35 infectious infectious JJ cord-309048-emmtplv3 63 36 plasmids plasmid NNS cord-309048-emmtplv3 63 37 , , , cord-309048-emmtplv3 63 38 in in IN cord-309048-emmtplv3 63 39 which which WDT cord-309048-emmtplv3 63 40 the the DT cord-309048-emmtplv3 63 41 viral viral JJ cord-309048-emmtplv3 63 42 cDNA cdna NN cord-309048-emmtplv3 63 43 is be VBZ cord-309048-emmtplv3 63 44 cloned clone VBN cord-309048-emmtplv3 63 45 between between IN cord-309048-emmtplv3 63 46 a a DT cord-309048-emmtplv3 63 47 strong strong JJ cord-309048-emmtplv3 63 48 promoter promoter NN cord-309048-emmtplv3 63 49 and and CC cord-309048-emmtplv3 63 50 a a DT cord-309048-emmtplv3 63 51 self self NN cord-309048-emmtplv3 63 52 - - HYPH cord-309048-emmtplv3 63 53 cleaving cleave VBG cord-309048-emmtplv3 63 54 ribozyme ribozyme NNS cord-309048-emmtplv3 63 55 to to TO cord-309048-emmtplv3 63 56 trim trim VB cord-309048-emmtplv3 63 57 the the DT cord-309048-emmtplv3 63 58 3 3 CD cord-309048-emmtplv3 63 59 0 0 CD cord-309048-emmtplv3 63 60 -terminus -terminus : cord-309048-emmtplv3 63 61 of of IN cord-309048-emmtplv3 63 62 the the DT cord-309048-emmtplv3 63 63 in in IN cord-309048-emmtplv3 63 64 vivo vivo NN cord-309048-emmtplv3 63 65 - - HYPH cord-309048-emmtplv3 63 66 transcribed transcribe VBN cord-309048-emmtplv3 63 67 RNA RNA NNP cord-309048-emmtplv3 63 68 ( ( -LRB- cord-309048-emmtplv3 63 69 Bittner Bittner NNP cord-309048-emmtplv3 63 70 et et NNP cord-309048-emmtplv3 63 71 al al NNP cord-309048-emmtplv3 63 72 . . NNP cord-309048-emmtplv3 63 73 , , , cord-309048-emmtplv3 63 74 2013 2013 CD cord-309048-emmtplv3 63 75 ; ; : cord-309048-emmtplv3 63 76 Kadri Kadri NNP cord-309048-emmtplv3 63 77 et et NNP cord-309048-emmtplv3 63 78 al al NNP cord-309048-emmtplv3 63 79 . . NNP cord-309048-emmtplv3 63 80 , , , cord-309048-emmtplv3 63 81 2011 2011 CD cord-309048-emmtplv3 63 82 ) ) -RRB- cord-309048-emmtplv3 63 83 , , , cord-309048-emmtplv3 63 84 mean mean VBP cord-309048-emmtplv3 63 85 that that IN cord-309048-emmtplv3 63 86 it -PRON- PRP cord-309048-emmtplv3 63 87 is be VBZ cord-309048-emmtplv3 63 88 now now RB cord-309048-emmtplv3 63 89 relatively relatively RB cord-309048-emmtplv3 63 90 straightforward straightforward JJ cord-309048-emmtplv3 63 91 to to TO cord-309048-emmtplv3 63 92 produce produce VB cord-309048-emmtplv3 63 93 genetically genetically RB cord-309048-emmtplv3 63 94 modified modify VBN cord-309048-emmtplv3 63 95 particles particle NNS cord-309048-emmtplv3 63 96 in in IN cord-309048-emmtplv3 63 97 plants plant NNS cord-309048-emmtplv3 63 98 . . . cord-309048-emmtplv3 64 1 Furthermore furthermore RB cord-309048-emmtplv3 64 2 , , , cord-309048-emmtplv3 64 3 developments development NNS cord-309048-emmtplv3 64 4 in in IN cord-309048-emmtplv3 64 5 the the DT cord-309048-emmtplv3 64 6 field field NN cord-309048-emmtplv3 64 7 of of IN cord-309048-emmtplv3 64 8 chemistry chemistry NN cord-309048-emmtplv3 64 9 have have VBP cord-309048-emmtplv3 64 10 opened open VBN cord-309048-emmtplv3 64 11 up up RP cord-309048-emmtplv3 64 12 possibilities possibility NNS cord-309048-emmtplv3 64 13 for for IN cord-309048-emmtplv3 64 14 the the DT cord-309048-emmtplv3 64 15 chemical chemical JJ cord-309048-emmtplv3 64 16 modification modification NN cord-309048-emmtplv3 64 17 of of IN cord-309048-emmtplv3 64 18 both both DT cord-309048-emmtplv3 64 19 wild wild JJ cord-309048-emmtplv3 64 20 - - HYPH cord-309048-emmtplv3 64 21 type type NN cord-309048-emmtplv3 64 22 and and CC cord-309048-emmtplv3 64 23 genetically genetically RB cord-309048-emmtplv3 64 24 altered alter VBN cord-309048-emmtplv3 64 25 particles particle NNS cord-309048-emmtplv3 64 26 ( ( -LRB- cord-309048-emmtplv3 64 27 Strable Strable NNP cord-309048-emmtplv3 64 28 and and CC cord-309048-emmtplv3 64 29 Finn Finn NNP cord-309048-emmtplv3 64 30 , , , cord-309048-emmtplv3 64 31 2009 2009 CD cord-309048-emmtplv3 64 32 ; ; : cord-309048-emmtplv3 64 33 Wen Wen NNP cord-309048-emmtplv3 64 34 and and CC cord-309048-emmtplv3 64 35 Steinmetz Steinmetz NNP cord-309048-emmtplv3 64 36 , , , cord-309048-emmtplv3 64 37 2016 2016 CD cord-309048-emmtplv3 64 38 ) ) -RRB- cord-309048-emmtplv3 64 39 . . . cord-309048-emmtplv3 65 1 These these DT cord-309048-emmtplv3 65 2 developments development NNS cord-309048-emmtplv3 65 3 are be VBP cord-309048-emmtplv3 65 4 outlined outline VBN cord-309048-emmtplv3 65 5 in in IN cord-309048-emmtplv3 65 6 Fig Fig NNP cord-309048-emmtplv3 65 7 . . . cord-309048-emmtplv3 66 1 2 2 LS cord-309048-emmtplv3 66 2 . . . cord-309048-emmtplv3 67 1 Their -PRON- PRP$ cord-309048-emmtplv3 67 2 highly highly RB cord-309048-emmtplv3 67 3 repetitive repetitive JJ cord-309048-emmtplv3 67 4 structure structure NN cord-309048-emmtplv3 67 5 and and CC cord-309048-emmtplv3 67 6 size size NN cord-309048-emmtplv3 67 7 , , , cord-309048-emmtplv3 67 8 coupled couple VBN cord-309048-emmtplv3 67 9 with with IN cord-309048-emmtplv3 67 10 detailed detailed JJ cord-309048-emmtplv3 67 11 knowledge knowledge NN cord-309048-emmtplv3 67 12 of of IN cord-309048-emmtplv3 67 13 their -PRON- PRP$ cord-309048-emmtplv3 67 14 3D 3d JJ cord-309048-emmtplv3 67 15 structure structure NN cord-309048-emmtplv3 67 16 , , , cord-309048-emmtplv3 67 17 make make VB cord-309048-emmtplv3 67 18 TMV TMV NNP cord-309048-emmtplv3 67 19 particles particle NNS cord-309048-emmtplv3 67 20 attractive attractive JJ cord-309048-emmtplv3 67 21 candidates candidate NNS cord-309048-emmtplv3 67 22 for for IN cord-309048-emmtplv3 67 23 the the DT cord-309048-emmtplv3 67 24 display display NN cord-309048-emmtplv3 67 25 of of IN cord-309048-emmtplv3 67 26 multiple multiple JJ cord-309048-emmtplv3 67 27 copies copy NNS cord-309048-emmtplv3 67 28 of of IN cord-309048-emmtplv3 67 29 peptides peptide NNS cord-309048-emmtplv3 67 30 . . . cord-309048-emmtplv3 68 1 To to TO cord-309048-emmtplv3 68 2 avoid avoid VB cord-309048-emmtplv3 68 3 disrupting disrupt VBG cord-309048-emmtplv3 68 4 CP cp NN cord-309048-emmtplv3 68 5 intersubunit intersubunit JJ cord-309048-emmtplv3 68 6 contacts contact NNS cord-309048-emmtplv3 68 7 and and CC cord-309048-emmtplv3 68 8 thereby thereby RB cord-309048-emmtplv3 68 9 interfering interfere VBG cord-309048-emmtplv3 68 10 with with IN cord-309048-emmtplv3 68 11 particle particle NN cord-309048-emmtplv3 68 12 formation formation NN cord-309048-emmtplv3 68 13 , , , cord-309048-emmtplv3 68 14 it -PRON- PRP cord-309048-emmtplv3 68 15 is be VBZ cord-309048-emmtplv3 68 16 essential essential JJ cord-309048-emmtplv3 68 17 that that IN cord-309048-emmtplv3 68 18 any any DT cord-309048-emmtplv3 68 19 inserted insert VBN cord-309048-emmtplv3 68 20 peptides peptide NNS cord-309048-emmtplv3 68 21 be be VB cord-309048-emmtplv3 68 22 presented present VBN cord-309048-emmtplv3 68 23 on on IN cord-309048-emmtplv3 68 24 a a DT cord-309048-emmtplv3 68 25 solvent solvent NN cord-309048-emmtplv3 68 26 - - HYPH cord-309048-emmtplv3 68 27 exposed expose VBN cord-309048-emmtplv3 68 28 surface surface NN cord-309048-emmtplv3 68 29 ; ; : cord-309048-emmtplv3 68 30 this this DT cord-309048-emmtplv3 68 31 should should MD cord-309048-emmtplv3 68 32 also also RB cord-309048-emmtplv3 68 33 ensure ensure VB cord-309048-emmtplv3 68 34 an an DT cord-309048-emmtplv3 68 35 effective effective JJ cord-309048-emmtplv3 68 36 interaction interaction NN cord-309048-emmtplv3 68 37 with with IN cord-309048-emmtplv3 68 38 the the DT cord-309048-emmtplv3 68 39 immune immune JJ cord-309048-emmtplv3 68 40 system system NN cord-309048-emmtplv3 68 41 if if IN cord-309048-emmtplv3 68 42 the the DT cord-309048-emmtplv3 68 43 displayed display VBN cord-309048-emmtplv3 68 44 peptides peptide NNS cord-309048-emmtplv3 68 45 are be VBP cord-309048-emmtplv3 68 46 intended intend VBN cord-309048-emmtplv3 68 47 to to TO cord-309048-emmtplv3 68 48 provoke provoke VB cord-309048-emmtplv3 68 49 an an DT cord-309048-emmtplv3 68 50 immune immune JJ cord-309048-emmtplv3 68 51 response response NN cord-309048-emmtplv3 68 52 . . . cord-309048-emmtplv3 69 1 The the DT cord-309048-emmtplv3 69 2 most most RBS cord-309048-emmtplv3 69 3 commonly commonly RB cord-309048-emmtplv3 69 4 used use VBN cord-309048-emmtplv3 69 5 position position NN cord-309048-emmtplv3 69 6 for for IN cord-309048-emmtplv3 69 7 the the DT cord-309048-emmtplv3 69 8 fusion fusion NN cord-309048-emmtplv3 69 9 of of IN cord-309048-emmtplv3 69 10 peptides peptide NNS cord-309048-emmtplv3 69 11 to to IN cord-309048-emmtplv3 69 12 the the DT cord-309048-emmtplv3 69 13 CP cp NN cord-309048-emmtplv3 69 14 is be VBZ cord-309048-emmtplv3 69 15 the the DT cord-309048-emmtplv3 69 16 C C NNP cord-309048-emmtplv3 69 17 - - HYPH cord-309048-emmtplv3 69 18 terminus terminus NN cord-309048-emmtplv3 69 19 ( ( -LRB- cord-309048-emmtplv3 69 20 Fig fig NN cord-309048-emmtplv3 69 21 . . . cord-309048-emmtplv3 70 1 1 1 LS cord-309048-emmtplv3 70 2 ) ) -RRB- cord-309048-emmtplv3 70 3 , , , cord-309048-emmtplv3 70 4 which which WDT cord-309048-emmtplv3 70 5 lies lie VBZ cord-309048-emmtplv3 70 6 on on IN cord-309048-emmtplv3 70 7 the the DT cord-309048-emmtplv3 70 8 outer outer JJ cord-309048-emmtplv3 70 9 surface surface NN cord-309048-emmtplv3 70 10 of of IN cord-309048-emmtplv3 70 11 assembled assemble VBN cord-309048-emmtplv3 70 12 virions virion NNS cord-309048-emmtplv3 70 13 . . . cord-309048-emmtplv3 71 1 Though though IN cord-309048-emmtplv3 71 2 the the DT cord-309048-emmtplv3 71 3 N n CD cord-309048-emmtplv3 71 4 - - HYPH cord-309048-emmtplv3 71 5 terminus terminus NN cord-309048-emmtplv3 71 6 is be VBZ cord-309048-emmtplv3 71 7 also also RB cord-309048-emmtplv3 71 8 surface surface NN cord-309048-emmtplv3 71 9 - - HYPH cord-309048-emmtplv3 71 10 exposed expose VBN cord-309048-emmtplv3 71 11 , , , cord-309048-emmtplv3 71 12 attempts attempt NNS cord-309048-emmtplv3 71 13 at at IN cord-309048-emmtplv3 71 14 fusing fuse VBG cord-309048-emmtplv3 71 15 peptides peptide NNS cord-309048-emmtplv3 71 16 to to IN cord-309048-emmtplv3 71 17 this this DT cord-309048-emmtplv3 71 18 position position NN cord-309048-emmtplv3 71 19 have have VBP cord-309048-emmtplv3 71 20 generally generally RB cord-309048-emmtplv3 71 21 prevented prevent VBN cord-309048-emmtplv3 71 22 particle particle NN cord-309048-emmtplv3 71 23 formation formation NN cord-309048-emmtplv3 71 24 , , , cord-309048-emmtplv3 71 25 probably probably RB cord-309048-emmtplv3 71 26 because because IN cord-309048-emmtplv3 71 27 of of IN cord-309048-emmtplv3 71 28 the the DT cord-309048-emmtplv3 71 29 proximity proximity NN cord-309048-emmtplv3 71 30 of of IN cord-309048-emmtplv3 71 31 amino amino NN cord-309048-emmtplv3 71 32 acids acid NNS cord-309048-emmtplv3 71 33 , , , cord-309048-emmtplv3 71 34 such such JJ cord-309048-emmtplv3 71 35 as as IN cord-309048-emmtplv3 71 36 the the DT cord-309048-emmtplv3 71 37 buried bury VBN cord-309048-emmtplv3 71 38 invariant invariant JJ cord-309048-emmtplv3 71 39 tyrosine tyrosine NN cord-309048-emmtplv3 71 40 at at IN cord-309048-emmtplv3 71 41 position position NN cord-309048-emmtplv3 71 42 2 2 CD cord-309048-emmtplv3 71 43 , , , cord-309048-emmtplv3 71 44 critical critical JJ cord-309048-emmtplv3 71 45 for for IN cord-309048-emmtplv3 71 46 particle particle NN cord-309048-emmtplv3 71 47 formation formation NN cord-309048-emmtplv3 71 48 ( ( -LRB- cord-309048-emmtplv3 71 49 Altschuh Altschuh NNP cord-309048-emmtplv3 71 50 et et NNP cord-309048-emmtplv3 71 51 al al NNP cord-309048-emmtplv3 71 52 . . NNP cord-309048-emmtplv3 71 53 , , , cord-309048-emmtplv3 71 54 1987 1987 CD cord-309048-emmtplv3 71 55 ) ) -RRB- cord-309048-emmtplv3 71 56 . . . cord-309048-emmtplv3 72 1 An an DT cord-309048-emmtplv3 72 2 early early JJ cord-309048-emmtplv3 72 3 report report NN cord-309048-emmtplv3 72 4 of of IN cord-309048-emmtplv3 72 5 the the DT cord-309048-emmtplv3 72 6 use use NN cord-309048-emmtplv3 72 7 TMV TMV NNP cord-309048-emmtplv3 72 8 particles particle NNS cord-309048-emmtplv3 72 9 to to TO cord-309048-emmtplv3 72 10 present present JJ cord-309048-emmtplv3 72 11 peptides peptide NNS cord-309048-emmtplv3 72 12 involved involve VBN cord-309048-emmtplv3 72 13 the the DT cord-309048-emmtplv3 72 14 CP CP NNP cord-309048-emmtplv3 72 15 expressed express VBN cord-309048-emmtplv3 72 16 in in IN cord-309048-emmtplv3 72 17 Escherichia Escherichia NNP cord-309048-emmtplv3 72 18 coli coli NNS cord-309048-emmtplv3 72 19 ( ( -LRB- cord-309048-emmtplv3 72 20 Haynes Haynes NNP cord-309048-emmtplv3 72 21 et et NNP cord-309048-emmtplv3 72 22 al al NNP cord-309048-emmtplv3 72 23 . . NNP cord-309048-emmtplv3 72 24 , , , cord-309048-emmtplv3 72 25 1986 1986 CD cord-309048-emmtplv3 72 26 ; ; : cord-309048-emmtplv3 72 27 discussed discuss VBN cord-309048-emmtplv3 72 28 in in IN cord-309048-emmtplv3 72 29 Section section NN cord-309048-emmtplv3 72 30 4 4 CD cord-309048-emmtplv3 72 31 ) ) -RRB- cord-309048-emmtplv3 72 32 . . . cord-309048-emmtplv3 73 1 The the DT cord-309048-emmtplv3 73 2 first first JJ cord-309048-emmtplv3 73 3 attempt attempt NN cord-309048-emmtplv3 73 4 to to TO cord-309048-emmtplv3 73 5 produce produce VB cord-309048-emmtplv3 73 6 TMV TMV NNP cord-309048-emmtplv3 73 7 particles particle NNS cord-309048-emmtplv3 73 8 containing contain VBG cord-309048-emmtplv3 73 9 a a DT cord-309048-emmtplv3 73 10 modified modify VBN cord-309048-emmtplv3 73 11 CP cp NN cord-309048-emmtplv3 73 12 in in IN cord-309048-emmtplv3 73 13 plants plant NNS cord-309048-emmtplv3 73 14 was be VBD cord-309048-emmtplv3 73 15 reported report VBN cord-309048-emmtplv3 73 16 by by IN cord-309048-emmtplv3 73 17 Takamatsu Takamatsu NNP cord-309048-emmtplv3 73 18 et et NNP cord-309048-emmtplv3 73 19 al al NNP cord-309048-emmtplv3 73 20 . . . cord-309048-emmtplv3 74 1 ( ( -LRB- cord-309048-emmtplv3 74 2 1990 1990 CD cord-309048-emmtplv3 74 3 ) ) -RRB- cord-309048-emmtplv3 74 4 . . . cord-309048-emmtplv3 75 1 A a DT cord-309048-emmtplv3 75 2 sequence sequence NN cord-309048-emmtplv3 75 3 encoding encode VBG cord-309048-emmtplv3 75 4 Leu Leu NNP cord-309048-emmtplv3 75 5 - - HYPH cord-309048-emmtplv3 75 6 enkephalin enkephalin NNP cord-309048-emmtplv3 75 7 was be VBD cord-309048-emmtplv3 75 8 fused fuse VBN cord-309048-emmtplv3 75 9 to to IN cord-309048-emmtplv3 75 10 the the DT cord-309048-emmtplv3 75 11 C c NN cord-309048-emmtplv3 75 12 - - HYPH cord-309048-emmtplv3 75 13 terminus terminus NN cord-309048-emmtplv3 75 14 of of IN cord-309048-emmtplv3 75 15 the the DT cord-309048-emmtplv3 75 16 viral viral JJ cord-309048-emmtplv3 75 17 CP cp NN cord-309048-emmtplv3 75 18 in in IN cord-309048-emmtplv3 75 19 an an DT cord-309048-emmtplv3 75 20 infectious infectious JJ cord-309048-emmtplv3 75 21 cDNA cdna NN cord-309048-emmtplv3 75 22 clone clone NN cord-309048-emmtplv3 75 23 of of IN cord-309048-emmtplv3 75 24 the the DT cord-309048-emmtplv3 75 25 virus virus NN cord-309048-emmtplv3 75 26 . . . cord-309048-emmtplv3 76 1 Inoculation inoculation NN cord-309048-emmtplv3 76 2 of of IN cord-309048-emmtplv3 76 3 tobacco tobacco NN cord-309048-emmtplv3 76 4 plants plant NNS cord-309048-emmtplv3 76 5 gave give VBD cord-309048-emmtplv3 76 6 only only JJ cord-309048-emmtplv3 76 7 local local JJ cord-309048-emmtplv3 76 8 lesions lesion NNS cord-309048-emmtplv3 76 9 , , , cord-309048-emmtplv3 76 10 and and CC cord-309048-emmtplv3 76 11 no no DT cord-309048-emmtplv3 76 12 particles particle NNS cord-309048-emmtplv3 76 13 could could MD cord-309048-emmtplv3 76 14 be be VB cord-309048-emmtplv3 76 15 purified purify VBN cord-309048-emmtplv3 76 16 despite despite IN cord-309048-emmtplv3 76 17 the the DT cord-309048-emmtplv3 76 18 efficient efficient JJ cord-309048-emmtplv3 76 19 synthesis synthesis NN cord-309048-emmtplv3 76 20 of of IN cord-309048-emmtplv3 76 21 the the DT cord-309048-emmtplv3 76 22 modified modify VBN cord-309048-emmtplv3 76 23 CP cp NN cord-309048-emmtplv3 76 24 . . . cord-309048-emmtplv3 77 1 This this DT cord-309048-emmtplv3 77 2 was be VBD cord-309048-emmtplv3 77 3 the the DT cord-309048-emmtplv3 77 4 first first JJ cord-309048-emmtplv3 77 5 indication indication NN cord-309048-emmtplv3 77 6 of of IN cord-309048-emmtplv3 77 7 a a DT cord-309048-emmtplv3 77 8 significant significant JJ cord-309048-emmtplv3 77 9 problem problem NN cord-309048-emmtplv3 77 10 with with IN cord-309048-emmtplv3 77 11 using use VBG cord-309048-emmtplv3 77 12 TMV TMV NNP cord-309048-emmtplv3 77 13 particles particle NNS cord-309048-emmtplv3 77 14 to to TO cord-309048-emmtplv3 77 15 display display VB cord-309048-emmtplv3 77 16 foreign foreign JJ cord-309048-emmtplv3 77 17 peptides peptide NNS cord-309048-emmtplv3 77 18 . . . cord-309048-emmtplv3 78 1 Although although IN cord-309048-emmtplv3 78 2 the the DT cord-309048-emmtplv3 78 3 large large JJ cord-309048-emmtplv3 78 4 number number NN cord-309048-emmtplv3 78 5 of of IN cord-309048-emmtplv3 78 6 subunits subunit NNS cord-309048-emmtplv3 78 7 within within IN cord-309048-emmtplv3 78 8 a a DT cord-309048-emmtplv3 78 9 virus virus NN cord-309048-emmtplv3 78 10 particle particle NN cord-309048-emmtplv3 78 11 makes make VBZ cord-309048-emmtplv3 78 12 TMV TMV NNP cord-309048-emmtplv3 78 13 very very RB cord-309048-emmtplv3 78 14 attractive attractive JJ cord-309048-emmtplv3 78 15 as as IN cord-309048-emmtplv3 78 16 a a DT cord-309048-emmtplv3 78 17 potential potential JJ cord-309048-emmtplv3 78 18 peptide peptide NN cord-309048-emmtplv3 78 19 display display NN cord-309048-emmtplv3 78 20 system system NN cord-309048-emmtplv3 78 21 , , , cord-309048-emmtplv3 78 22 it -PRON- PRP cord-309048-emmtplv3 78 23 has have VBZ cord-309048-emmtplv3 78 24 the the DT cord-309048-emmtplv3 78 25 drawback drawback NN cord-309048-emmtplv3 78 26 that that IN cord-309048-emmtplv3 78 27 the the DT cord-309048-emmtplv3 78 28 subunits subunit NNS cord-309048-emmtplv3 78 29 are be VBP cord-309048-emmtplv3 78 30 very very RB cord-309048-emmtplv3 78 31 tightly tightly RB cord-309048-emmtplv3 78 32 packed packed JJ cord-309048-emmtplv3 78 33 , , , cord-309048-emmtplv3 78 34 allowing allow VBG cord-309048-emmtplv3 78 35 little little JJ cord-309048-emmtplv3 78 36 space space NN cord-309048-emmtplv3 78 37 on on IN cord-309048-emmtplv3 78 38 the the DT cord-309048-emmtplv3 78 39 virus virus NN cord-309048-emmtplv3 78 40 surface surface NN cord-309048-emmtplv3 78 41 for for IN cord-309048-emmtplv3 78 42 the the DT cord-309048-emmtplv3 78 43 accommodation accommodation NN cord-309048-emmtplv3 78 44 of of IN cord-309048-emmtplv3 78 45 multiple multiple JJ cord-309048-emmtplv3 78 46 copies copy NNS cord-309048-emmtplv3 78 47 of of IN cord-309048-emmtplv3 78 48 a a DT cord-309048-emmtplv3 78 49 heterologous heterologous JJ cord-309048-emmtplv3 78 50 peptide peptide NN cord-309048-emmtplv3 78 51 . . . cord-309048-emmtplv3 79 1 In in IN cord-309048-emmtplv3 79 2 addition addition NN cord-309048-emmtplv3 79 3 , , , cord-309048-emmtplv3 79 4 mutations mutation NNS cord-309048-emmtplv3 79 5 near near IN cord-309048-emmtplv3 79 6 the the DT cord-309048-emmtplv3 79 7 C C NNP cord-309048-emmtplv3 79 8 - - HYPH cord-309048-emmtplv3 79 9 terminus terminus NN cord-309048-emmtplv3 79 10 adversely adversely RB cord-309048-emmtplv3 79 11 affect affect VBP cord-309048-emmtplv3 79 12 the the DT cord-309048-emmtplv3 79 13 ability ability NN cord-309048-emmtplv3 79 14 of of IN cord-309048-emmtplv3 79 15 CP cp NN cord-309048-emmtplv3 79 16 subunits subunit NNS cord-309048-emmtplv3 79 17 to to IN cord-309048-emmtplv3 79 18 oligomerize oligomerize NNP cord-309048-emmtplv3 79 19 , , , cord-309048-emmtplv3 79 20 thereby thereby RB cord-309048-emmtplv3 79 21 compromising compromise VBG cord-309048-emmtplv3 79 22 assembly assembly NN cord-309048-emmtplv3 79 23 . . . cord-309048-emmtplv3 80 1 Nonetheless nonetheless RB cord-309048-emmtplv3 80 2 , , , cord-309048-emmtplv3 80 3 the the DT cord-309048-emmtplv3 80 4 successful successful JJ cord-309048-emmtplv3 80 5 formation formation NN cord-309048-emmtplv3 80 6 of of IN cord-309048-emmtplv3 80 7 particles particle NNS cord-309048-emmtplv3 80 8 was be VBD cord-309048-emmtplv3 80 9 later later RB cord-309048-emmtplv3 80 10 reported report VBN cord-309048-emmtplv3 80 11 when when WRB cord-309048-emmtplv3 80 12 an an DT cord-309048-emmtplv3 80 13 11-amino 11-amino CD cord-309048-emmtplv3 80 14 acid acid NN cord-309048-emmtplv3 80 15 epitope epitope NN cord-309048-emmtplv3 80 16 from from IN cord-309048-emmtplv3 80 17 VP1 VP1 NNP cord-309048-emmtplv3 80 18 of of IN cord-309048-emmtplv3 80 19 foot foot NN cord-309048-emmtplv3 80 20 and and CC cord-309048-emmtplv3 80 21 mouth mouth NN cord-309048-emmtplv3 80 22 disease disease NN cord-309048-emmtplv3 80 23 virus virus NN cord-309048-emmtplv3 80 24 ( ( -LRB- cord-309048-emmtplv3 80 25 FMDV FMDV NNP cord-309048-emmtplv3 80 26 ) ) -RRB- cord-309048-emmtplv3 80 27 was be VBD cord-309048-emmtplv3 80 28 fused fuse VBN cord-309048-emmtplv3 80 29 to to IN cord-309048-emmtplv3 80 30 the the DT cord-309048-emmtplv3 80 31 extreme extreme JJ cord-309048-emmtplv3 80 32 C c NN cord-309048-emmtplv3 80 33 - - HYPH cord-309048-emmtplv3 80 34 terminus terminus NN cord-309048-emmtplv3 80 35 of of IN cord-309048-emmtplv3 80 36 the the DT cord-309048-emmtplv3 80 37 CP cp NN cord-309048-emmtplv3 81 1 ( ( -LRB- cord-309048-emmtplv3 81 2 Wu Wu NNP cord-309048-emmtplv3 81 3 et et NNP cord-309048-emmtplv3 81 4 al al NNP cord-309048-emmtplv3 81 5 . . NNP cord-309048-emmtplv3 81 6 , , , cord-309048-emmtplv3 81 7 2003 2003 CD cord-309048-emmtplv3 81 8 ) ) -RRB- cord-309048-emmtplv3 81 9 . . . cord-309048-emmtplv3 82 1 The the DT cord-309048-emmtplv3 82 2 purified purify VBN cord-309048-emmtplv3 82 3 particles particle NNS cord-309048-emmtplv3 82 4 could could MD cord-309048-emmtplv3 82 5 protect protect VB cord-309048-emmtplv3 82 6 a a DT cord-309048-emmtplv3 82 7 number number NN cord-309048-emmtplv3 82 8 of of IN cord-309048-emmtplv3 82 9 target target NN cord-309048-emmtplv3 82 10 animals animal NNS cord-309048-emmtplv3 82 11 , , , cord-309048-emmtplv3 82 12 including include VBG cord-309048-emmtplv3 82 13 pigs pig NNS cord-309048-emmtplv3 82 14 , , , cord-309048-emmtplv3 82 15 against against IN cord-309048-emmtplv3 82 16 challenge challenge NN cord-309048-emmtplv3 82 17 with with IN cord-309048-emmtplv3 82 18 FMDV FMDV NNP cord-309048-emmtplv3 82 19 . . . cord-309048-emmtplv3 83 1 Hexahistidine Hexahistidine NNP cord-309048-emmtplv3 83 2 tags tag NNS cord-309048-emmtplv3 83 3 were be VBD cord-309048-emmtplv3 83 4 also also RB cord-309048-emmtplv3 83 5 shown show VBN cord-309048-emmtplv3 83 6 to to TO cord-309048-emmtplv3 83 7 be be VB cord-309048-emmtplv3 83 8 tolerated tolerate VBN cord-309048-emmtplv3 83 9 as as IN cord-309048-emmtplv3 83 10 3 3 CD cord-309048-emmtplv3 83 11 0 0 CD cord-309048-emmtplv3 83 12 -terminal -terminal JJ cord-309048-emmtplv3 83 13 extensions extension NNS cord-309048-emmtplv3 83 14 to to IN cord-309048-emmtplv3 83 15 all all DT cord-309048-emmtplv3 83 16 TMV TMV NNP cord-309048-emmtplv3 83 17 CPs cp NNS cord-309048-emmtplv3 83 18 but but CC cord-309048-emmtplv3 83 19 substantially substantially RB cord-309048-emmtplv3 83 20 reduced reduce VBN cord-309048-emmtplv3 83 21 particle particle NN cord-309048-emmtplv3 83 22 formation formation NN cord-309048-emmtplv3 83 23 . . . cord-309048-emmtplv3 84 1 An an DT cord-309048-emmtplv3 84 2 initial initial JJ cord-309048-emmtplv3 84 3 approach approach NN cord-309048-emmtplv3 84 4 to to IN cord-309048-emmtplv3 84 5 solving solve VBG cord-309048-emmtplv3 84 6 the the DT cord-309048-emmtplv3 84 7 problem problem NN cord-309048-emmtplv3 84 8 of of IN cord-309048-emmtplv3 84 9 steric steric JJ cord-309048-emmtplv3 84 10 crowding crowding NN cord-309048-emmtplv3 84 11 was be VBD cord-309048-emmtplv3 84 12 the the DT cord-309048-emmtplv3 84 13 creation creation NN cord-309048-emmtplv3 84 14 of of IN cord-309048-emmtplv3 84 15 mosaic mosaic JJ cord-309048-emmtplv3 84 16 particles particle NNS cord-309048-emmtplv3 84 17 containing contain VBG cord-309048-emmtplv3 84 18 a a DT cord-309048-emmtplv3 84 19 mixture mixture NN cord-309048-emmtplv3 84 20 of of IN cord-309048-emmtplv3 84 21 wild wild JJ cord-309048-emmtplv3 84 22 - - HYPH cord-309048-emmtplv3 84 23 type type NN cord-309048-emmtplv3 84 24 and and CC cord-309048-emmtplv3 84 25 modified modify VBN cord-309048-emmtplv3 84 26 subunits subunit NNS cord-309048-emmtplv3 84 27 . . . cord-309048-emmtplv3 85 1 This this DT cord-309048-emmtplv3 85 2 was be VBD cord-309048-emmtplv3 85 3 achieved achieve VBN cord-309048-emmtplv3 85 4 by by IN cord-309048-emmtplv3 85 5 incorporating incorporate VBG cord-309048-emmtplv3 85 6 a a DT cord-309048-emmtplv3 85 7 leaky leaky JJ cord-309048-emmtplv3 85 8 termination termination NN cord-309048-emmtplv3 85 9 codon codon NN cord-309048-emmtplv3 85 10 at at IN cord-309048-emmtplv3 85 11 the the DT cord-309048-emmtplv3 85 12 C C NNP cord-309048-emmtplv3 85 13 - - HYPH cord-309048-emmtplv3 85 14 terminus terminus NN cord-309048-emmtplv3 85 15 of of IN cord-309048-emmtplv3 85 16 the the DT cord-309048-emmtplv3 85 17 CP cp NN cord-309048-emmtplv3 85 18 gene gene NN cord-309048-emmtplv3 85 19 and and CC cord-309048-emmtplv3 85 20 placing place VBG cord-309048-emmtplv3 85 21 the the DT cord-309048-emmtplv3 85 22 sequence sequence NN cord-309048-emmtplv3 85 23 of of IN cord-309048-emmtplv3 85 24 the the DT cord-309048-emmtplv3 85 25 target target NN cord-309048-emmtplv3 85 26 , , , cord-309048-emmtplv3 85 27 antigenic antigenic JJ cord-309048-emmtplv3 85 28 peptides peptide NNS cord-309048-emmtplv3 85 29 immediately immediately RB cord-309048-emmtplv3 85 30 downstream downstream RB cord-309048-emmtplv3 86 1 ( ( -LRB- cord-309048-emmtplv3 86 2 Hamamoto Hamamoto NNP cord-309048-emmtplv3 86 3 et et NNP cord-309048-emmtplv3 86 4 al al NNP cord-309048-emmtplv3 86 5 . . NNP cord-309048-emmtplv3 86 6 , , , cord-309048-emmtplv3 86 7 1993 1993 CD cord-309048-emmtplv3 87 1 ; ; : cord-309048-emmtplv3 87 2 Sugiyama Sugiyama NNP cord-309048-emmtplv3 87 3 et et NNP cord-309048-emmtplv3 87 4 al al NNP cord-309048-emmtplv3 87 5 . . NNP cord-309048-emmtplv3 87 6 , , , cord-309048-emmtplv3 87 7 1995 1995 CD cord-309048-emmtplv3 87 8 ; ; : cord-309048-emmtplv3 87 9 Turpen Turpen NNP cord-309048-emmtplv3 87 10 et et FW cord-309048-emmtplv3 87 11 al al NNP cord-309048-emmtplv3 87 12 . . NNP cord-309048-emmtplv3 87 13 , , , cord-309048-emmtplv3 87 14 1995 1995 CD cord-309048-emmtplv3 87 15 ) ) -RRB- cord-309048-emmtplv3 87 16 . . . cord-309048-emmtplv3 88 1 This this DT cord-309048-emmtplv3 88 2 resulted result VBD cord-309048-emmtplv3 88 3 in in IN cord-309048-emmtplv3 88 4 the the DT cord-309048-emmtplv3 88 5 production production NN cord-309048-emmtplv3 88 6 of of IN cord-309048-emmtplv3 88 7 particles particle NNS cord-309048-emmtplv3 88 8 in in IN cord-309048-emmtplv3 88 9 which which WDT cord-309048-emmtplv3 88 10 up up IN cord-309048-emmtplv3 88 11 to to TO cord-309048-emmtplv3 88 12 5 5 CD cord-309048-emmtplv3 88 13 % % NN cord-309048-emmtplv3 88 14 of of IN cord-309048-emmtplv3 88 15 the the DT cord-309048-emmtplv3 88 16 subunits subunit NNS cord-309048-emmtplv3 88 17 were be VBD cord-309048-emmtplv3 88 18 fusion fusion NN cord-309048-emmtplv3 88 19 proteins protein NNS cord-309048-emmtplv3 88 20 containing contain VBG cord-309048-emmtplv3 88 21 the the DT cord-309048-emmtplv3 88 22 heterologous heterologous JJ cord-309048-emmtplv3 88 23 peptide peptide NN cord-309048-emmtplv3 88 24 at at IN cord-309048-emmtplv3 88 25 their -PRON- PRP$ cord-309048-emmtplv3 88 26 C C NNP cord-309048-emmtplv3 88 27 - - HYPH cord-309048-emmtplv3 88 28 termini termini NNP cord-309048-emmtplv3 88 29 . . . cord-309048-emmtplv3 89 1 However however RB cord-309048-emmtplv3 89 2 , , , cord-309048-emmtplv3 89 3 in in IN cord-309048-emmtplv3 89 4 each each DT cord-309048-emmtplv3 89 5 case case NN cord-309048-emmtplv3 89 6 the the DT cord-309048-emmtplv3 89 7 presented present VBN cord-309048-emmtplv3 89 8 peptide peptide NN cord-309048-emmtplv3 89 9 was be VBD cord-309048-emmtplv3 89 10 quite quite RB cord-309048-emmtplv3 89 11 short short JJ cord-309048-emmtplv3 89 12 ( ( -LRB- cord-309048-emmtplv3 89 13 less less JJR cord-309048-emmtplv3 89 14 than than IN cord-309048-emmtplv3 89 15 20 20 CD cord-309048-emmtplv3 89 16 amino amino JJ cord-309048-emmtplv3 89 17 acids acid NNS cord-309048-emmtplv3 89 18 ) ) -RRB- cord-309048-emmtplv3 89 19 . . . cord-309048-emmtplv3 90 1 A a DT cord-309048-emmtplv3 90 2 conceptually conceptually RB cord-309048-emmtplv3 90 3 similar similar JJ cord-309048-emmtplv3 90 4 , , , cord-309048-emmtplv3 90 5 but but CC cord-309048-emmtplv3 90 6 mechanistically mechanistically RB cord-309048-emmtplv3 90 7 different different JJ cord-309048-emmtplv3 90 8 , , , cord-309048-emmtplv3 90 9 approach approach VBP cord-309048-emmtplv3 90 10 to to IN cord-309048-emmtplv3 90 11 creating create VBG cord-309048-emmtplv3 90 12 mosaic mosaic JJ cord-309048-emmtplv3 90 13 particles particle NNS cord-309048-emmtplv3 90 14 was be VBD cord-309048-emmtplv3 90 15 adopted adopt VBN cord-309048-emmtplv3 90 16 by by IN cord-309048-emmtplv3 90 17 R€ R€ NNP cord-309048-emmtplv3 90 18 oder oder NNP cord-309048-emmtplv3 90 19 et et NNP cord-309048-emmtplv3 90 20 al al NNP cord-309048-emmtplv3 90 21 . . . cord-309048-emmtplv3 91 1 ( ( -LRB- cord-309048-emmtplv3 91 2 2017 2017 CD cord-309048-emmtplv3 91 3 ) ) -RRB- cord-309048-emmtplv3 91 4 to to TO cord-309048-emmtplv3 91 5 express express VB cord-309048-emmtplv3 91 6 longer long JJR cord-309048-emmtplv3 91 7 peptides peptide NNS cord-309048-emmtplv3 91 8 . . . cord-309048-emmtplv3 92 1 In in IN cord-309048-emmtplv3 92 2 this this DT cord-309048-emmtplv3 92 3 case case NN cord-309048-emmtplv3 92 4 the the DT cord-309048-emmtplv3 92 5 sequence sequence NN cord-309048-emmtplv3 92 6 of of IN cord-309048-emmtplv3 92 7 the the DT cord-309048-emmtplv3 92 8 113-amino 113-amino CD cord-309048-emmtplv3 92 9 acid acid NN cord-309048-emmtplv3 92 10 fluorescent fluorescent NN cord-309048-emmtplv3 92 11 protein protein NN cord-309048-emmtplv3 92 12 iLOV ilov NN cord-309048-emmtplv3 92 13 was be VBD cord-309048-emmtplv3 92 14 fused fuse VBN cord-309048-emmtplv3 92 15 to to IN cord-309048-emmtplv3 92 16 the the DT cord-309048-emmtplv3 92 17 C c NN cord-309048-emmtplv3 92 18 - - HYPH cord-309048-emmtplv3 92 19 terminus terminus NN cord-309048-emmtplv3 92 20 of of IN cord-309048-emmtplv3 92 21 the the DT cord-309048-emmtplv3 92 22 CP cp NN cord-309048-emmtplv3 92 23 via via IN cord-309048-emmtplv3 92 24 a a DT cord-309048-emmtplv3 92 25 16-amino 16-amino CD cord-309048-emmtplv3 92 26 acid acid NN cord-309048-emmtplv3 92 27 2A 2a NN cord-309048-emmtplv3 92 28 " " '' cord-309048-emmtplv3 92 29 ribosomal ribosomal JJ cord-309048-emmtplv3 92 30 skip skip VBP cord-309048-emmtplv3 92 31 " " '' cord-309048-emmtplv3 92 32 peptide peptide NN cord-309048-emmtplv3 92 33 from from IN cord-309048-emmtplv3 92 34 FMDV FMDV NNP cord-309048-emmtplv3 93 1 ( ( -LRB- cord-309048-emmtplv3 93 2 Donnelly Donnelly NNP cord-309048-emmtplv3 93 3 et et NNP cord-309048-emmtplv3 93 4 al al NNP cord-309048-emmtplv3 93 5 . . NNP cord-309048-emmtplv3 93 6 , , , cord-309048-emmtplv3 93 7 2001 2001 CD cord-309048-emmtplv3 93 8 ) ) -RRB- cord-309048-emmtplv3 93 9 . . . cord-309048-emmtplv3 94 1 Particles particle NNS cord-309048-emmtplv3 94 2 isolated isolate VBN cord-309048-emmtplv3 94 3 from from IN cord-309048-emmtplv3 94 4 plants plant NNS cord-309048-emmtplv3 94 5 infected infect VBN cord-309048-emmtplv3 94 6 with with IN cord-309048-emmtplv3 94 7 this this DT cord-309048-emmtplv3 94 8 construct construct NN cord-309048-emmtplv3 94 9 contained contain VBN cord-309048-emmtplv3 94 10 iLOV ilov NN cord-309048-emmtplv3 94 11 fusion fusion NN cord-309048-emmtplv3 94 12 subunits subunit NNS cord-309048-emmtplv3 94 13 , , , cord-309048-emmtplv3 94 14 suggesting suggest VBG cord-309048-emmtplv3 94 15 this this DT cord-309048-emmtplv3 94 16 approach approach NN cord-309048-emmtplv3 94 17 could could MD cord-309048-emmtplv3 94 18 be be VB cord-309048-emmtplv3 94 19 used use VBN cord-309048-emmtplv3 94 20 to to TO cord-309048-emmtplv3 94 21 express express VB cord-309048-emmtplv3 94 22 whole whole JJ cord-309048-emmtplv3 94 23 proteins protein NNS cord-309048-emmtplv3 94 24 on on IN cord-309048-emmtplv3 94 25 the the DT cord-309048-emmtplv3 94 26 surface surface NN cord-309048-emmtplv3 94 27 of of IN cord-309048-emmtplv3 94 28 TMV TMV NNP cord-309048-emmtplv3 94 29 particles particle NNS cord-309048-emmtplv3 94 30 . . . cord-309048-emmtplv3 95 1 The the DT cord-309048-emmtplv3 95 2 disadvantage disadvantage NN cord-309048-emmtplv3 95 3 of of IN cord-309048-emmtplv3 95 4 the the DT cord-309048-emmtplv3 95 5 mosaic mosaic JJ cord-309048-emmtplv3 95 6 approach approach NN cord-309048-emmtplv3 95 7 is be VBZ cord-309048-emmtplv3 95 8 that that IN cord-309048-emmtplv3 95 9 it -PRON- PRP cord-309048-emmtplv3 95 10 is be VBZ cord-309048-emmtplv3 95 11 difficult difficult JJ cord-309048-emmtplv3 95 12 to to TO cord-309048-emmtplv3 95 13 control control VB cord-309048-emmtplv3 95 14 the the DT cord-309048-emmtplv3 95 15 number number NN cord-309048-emmtplv3 95 16 and and CC cord-309048-emmtplv3 95 17 spatial spatial JJ cord-309048-emmtplv3 95 18 distribution distribution NN cord-309048-emmtplv3 95 19 of of IN cord-309048-emmtplv3 95 20 modified modify VBN cord-309048-emmtplv3 95 21 subunits subunit NNS cord-309048-emmtplv3 95 22 within within IN cord-309048-emmtplv3 95 23 the the DT cord-309048-emmtplv3 95 24 particles particle NNS cord-309048-emmtplv3 95 25 . . . cord-309048-emmtplv3 96 1 Thus thus RB cord-309048-emmtplv3 96 2 , , , cord-309048-emmtplv3 96 3 several several JJ cord-309048-emmtplv3 96 4 alternative alternative JJ cord-309048-emmtplv3 96 5 approaches approach NNS cord-309048-emmtplv3 96 6 for for IN cord-309048-emmtplv3 96 7 peptide peptide JJ cord-309048-emmtplv3 96 8 insertion insertion NN cord-309048-emmtplv3 96 9 into into IN cord-309048-emmtplv3 96 10 the the DT cord-309048-emmtplv3 96 11 CP cp NN cord-309048-emmtplv3 96 12 have have VBP cord-309048-emmtplv3 96 13 been be VBN cord-309048-emmtplv3 96 14 developed develop VBN cord-309048-emmtplv3 96 15 to to TO cord-309048-emmtplv3 96 16 produce produce VB cord-309048-emmtplv3 96 17 particles particle NNS cord-309048-emmtplv3 96 18 in in IN cord-309048-emmtplv3 96 19 which which WDT cord-309048-emmtplv3 96 20 all all PDT cord-309048-emmtplv3 96 21 the the DT cord-309048-emmtplv3 96 22 CP cp NN cord-309048-emmtplv3 96 23 subunits subunit NNS cord-309048-emmtplv3 96 24 are be VBP cord-309048-emmtplv3 96 25 modified modify VBN cord-309048-emmtplv3 96 26 while while IN cord-309048-emmtplv3 96 27 retaining retain VBG cord-309048-emmtplv3 96 28 virus virus NN cord-309048-emmtplv3 96 29 viability viability NN cord-309048-emmtplv3 96 30 . . . cord-309048-emmtplv3 97 1 Turpen Turpen NNP cord-309048-emmtplv3 97 2 et et FW cord-309048-emmtplv3 97 3 al al NNP cord-309048-emmtplv3 97 4 . . . cord-309048-emmtplv3 98 1 ( ( -LRB- cord-309048-emmtplv3 98 2 1995 1995 CD cord-309048-emmtplv3 98 3 ) ) -RRB- cord-309048-emmtplv3 98 4 investigated investigate VBD cord-309048-emmtplv3 98 5 the the DT cord-309048-emmtplv3 98 6 use use NN cord-309048-emmtplv3 98 7 of of IN cord-309048-emmtplv3 98 8 a a DT cord-309048-emmtplv3 98 9 surface surface NN cord-309048-emmtplv3 98 10 - - HYPH cord-309048-emmtplv3 98 11 exposed expose VBN cord-309048-emmtplv3 98 12 loop loop NN cord-309048-emmtplv3 98 13 , , , cord-309048-emmtplv3 98 14 downstream downstream RB cord-309048-emmtplv3 98 15 of of IN cord-309048-emmtplv3 98 16 proline proline NNP cord-309048-emmtplv3 98 17 63 63 CD cord-309048-emmtplv3 98 18 , , , cord-309048-emmtplv3 98 19 between between IN cord-309048-emmtplv3 98 20 two two CD cord-309048-emmtplv3 98 21 of of IN cord-309048-emmtplv3 98 22 the the DT cord-309048-emmtplv3 98 23 α α NN cord-309048-emmtplv3 98 24 - - HYPH cord-309048-emmtplv3 98 25 helices helix NNS cord-309048-emmtplv3 98 26 ( ( -LRB- cord-309048-emmtplv3 98 27 Fig Fig NNP cord-309048-emmtplv3 98 28 . . . cord-309048-emmtplv3 98 29 1A 1a NN cord-309048-emmtplv3 98 30 and and CC cord-309048-emmtplv3 98 31 B B NNP cord-309048-emmtplv3 98 32 ) ) -RRB- cord-309048-emmtplv3 98 33 , , , cord-309048-emmtplv3 98 34 to to TO cord-309048-emmtplv3 98 35 express express VB cord-309048-emmtplv3 98 36 malarial malarial JJ cord-309048-emmtplv3 98 37 epitopes epitope NNS cord-309048-emmtplv3 98 38 on on IN cord-309048-emmtplv3 98 39 the the DT cord-309048-emmtplv3 98 40 virus virus NN cord-309048-emmtplv3 98 41 surface surface NN cord-309048-emmtplv3 98 42 , , , cord-309048-emmtplv3 98 43 and and CC cord-309048-emmtplv3 98 44 demonstrated demonstrate VBD cord-309048-emmtplv3 98 45 particle particle NN cord-309048-emmtplv3 98 46 formation formation NN cord-309048-emmtplv3 98 47 . . . cord-309048-emmtplv3 99 1 A a DT cord-309048-emmtplv3 99 2 similar similar JJ cord-309048-emmtplv3 99 3 site site NN cord-309048-emmtplv3 99 4 was be VBD cord-309048-emmtplv3 99 5 later later RB cord-309048-emmtplv3 99 6 used use VBN cord-309048-emmtplv3 99 7 to to TO cord-309048-emmtplv3 99 8 express express VB cord-309048-emmtplv3 99 9 a a DT cord-309048-emmtplv3 99 10 10-amino 10-amino CD cord-309048-emmtplv3 99 11 acid acid NN cord-309048-emmtplv3 99 12 metal metal NN cord-309048-emmtplv3 99 13 - - HYPH cord-309048-emmtplv3 99 14 binding bind VBG cord-309048-emmtplv3 99 15 peptide peptide NN cord-309048-emmtplv3 99 16 that that WDT cord-309048-emmtplv3 99 17 catalyzed catalyze VBD cord-309048-emmtplv3 99 18 the the DT cord-309048-emmtplv3 99 19 deposition deposition NN cord-309048-emmtplv3 99 20 of of IN cord-309048-emmtplv3 99 21 gold gold NN cord-309048-emmtplv3 99 22 on on IN cord-309048-emmtplv3 99 23 the the DT cord-309048-emmtplv3 99 24 surface surface NN cord-309048-emmtplv3 99 25 of of IN cord-309048-emmtplv3 99 26 purified purify VBN cord-309048-emmtplv3 99 27 particles particle NNS cord-309048-emmtplv3 100 1 ( ( -LRB- cord-309048-emmtplv3 100 2 Love love NN cord-309048-emmtplv3 100 3 et et NNP cord-309048-emmtplv3 100 4 al al NNP cord-309048-emmtplv3 100 5 . . . cord-309048-emmtplv3 101 1 , , , cord-309048-emmtplv3 101 2 2015 2015 CD cord-309048-emmtplv3 101 3 ) ) -RRB- cord-309048-emmtplv3 101 4 . . . cord-309048-emmtplv3 102 1 Using use VBG cord-309048-emmtplv3 102 2 a a DT cord-309048-emmtplv3 102 3 TMV TMV NNP cord-309048-emmtplv3 102 4 vector vector NN cord-309048-emmtplv3 102 5 that that WDT cord-309048-emmtplv3 102 6 allowed allow VBD cord-309048-emmtplv3 102 7 peptides peptide NNS cord-309048-emmtplv3 102 8 to to TO cord-309048-emmtplv3 102 9 be be VB cord-309048-emmtplv3 102 10 inserted insert VBN cord-309048-emmtplv3 102 11 just just RB cord-309048-emmtplv3 102 12 upstream upstream RB cord-309048-emmtplv3 102 13 of of IN cord-309048-emmtplv3 102 14 the the DT cord-309048-emmtplv3 102 15 C c NN cord-309048-emmtplv3 102 16 - - HYPH cord-309048-emmtplv3 102 17 terminus terminus NN cord-309048-emmtplv3 102 18 of of IN cord-309048-emmtplv3 102 19 the the DT cord-309048-emmtplv3 102 20 CP cp NN cord-309048-emmtplv3 102 21 ( ( -LRB- cord-309048-emmtplv3 102 22 after after IN cord-309048-emmtplv3 102 23 amino amino NN cord-309048-emmtplv3 102 24 acid acid NN cord-309048-emmtplv3 102 25 154 154 CD cord-309048-emmtplv3 102 26 ) ) -RRB- cord-309048-emmtplv3 102 27 , , , cord-309048-emmtplv3 102 28 Fitchen Fitchen NNP cord-309048-emmtplv3 102 29 et et NNP cord-309048-emmtplv3 102 30 al al NNP cord-309048-emmtplv3 102 31 . . . cord-309048-emmtplv3 103 1 ( ( -LRB- cord-309048-emmtplv3 103 2 1995 1995 CD cord-309048-emmtplv3 103 3 ) ) -RRB- cord-309048-emmtplv3 103 4 expressed express VBD cord-309048-emmtplv3 103 5 a a DT cord-309048-emmtplv3 103 6 13-amino 13-amino CD cord-309048-emmtplv3 103 7 acid acid NN cord-309048-emmtplv3 103 8 peptide peptide NN cord-309048-emmtplv3 103 9 from from IN cord-309048-emmtplv3 103 10 the the DT cord-309048-emmtplv3 103 11 glycoprotein glycoprotein NN cord-309048-emmtplv3 103 12 ZP3 zp3 NN cord-309048-emmtplv3 103 13 from from IN cord-309048-emmtplv3 103 14 the the DT cord-309048-emmtplv3 103 15 murine murine JJ cord-309048-emmtplv3 103 16 zona zona NNP cord-309048-emmtplv3 103 17 pellucida pellucida NN cord-309048-emmtplv3 103 18 . . . cord-309048-emmtplv3 104 1 A a DT cord-309048-emmtplv3 104 2 detailed detailed JJ cord-309048-emmtplv3 104 3 analysis analysis NN cord-309048-emmtplv3 104 4 of of IN cord-309048-emmtplv3 104 5 the the DT cord-309048-emmtplv3 104 6 size size NN cord-309048-emmtplv3 104 7 and and CC cord-309048-emmtplv3 104 8 charge charge NN cord-309048-emmtplv3 104 9 of of IN cord-309048-emmtplv3 104 10 peptides peptide NNS cord-309048-emmtplv3 104 11 that that WDT cord-309048-emmtplv3 104 12 could could MD cord-309048-emmtplv3 104 13 be be VB cord-309048-emmtplv3 104 14 successfully successfully RB cord-309048-emmtplv3 104 15 displayed display VBN cord-309048-emmtplv3 104 16 at at IN cord-309048-emmtplv3 104 17 this this DT cord-309048-emmtplv3 104 18 site site NN cord-309048-emmtplv3 104 19 showed show VBD cord-309048-emmtplv3 104 20 that that IN cord-309048-emmtplv3 104 21 sequences sequence NNS cord-309048-emmtplv3 104 22 of of IN cord-309048-emmtplv3 104 23 up up IN cord-309048-emmtplv3 104 24 to to TO cord-309048-emmtplv3 104 25 23 23 CD cord-309048-emmtplv3 104 26 amino amino NN cord-309048-emmtplv3 104 27 acids acid NNS cord-309048-emmtplv3 104 28 were be VBD cord-309048-emmtplv3 104 29 tolerated tolerate VBN cord-309048-emmtplv3 104 30 provided provide VBN cord-309048-emmtplv3 104 31 their -PRON- PRP$ cord-309048-emmtplv3 104 32 isoelectric isoelectric JJ cord-309048-emmtplv3 104 33 point point NN cord-309048-emmtplv3 104 34 was be VBD cord-309048-emmtplv3 104 35 below below IN cord-309048-emmtplv3 104 36 7.0 7.0 CD cord-309048-emmtplv3 104 37 . . . cord-309048-emmtplv3 105 1 Using use VBG cord-309048-emmtplv3 105 2 this this DT cord-309048-emmtplv3 105 3 information information NN cord-309048-emmtplv3 105 4 , , , cord-309048-emmtplv3 105 5 Koo Koo NNP cord-309048-emmtplv3 105 6 et et FW cord-309048-emmtplv3 105 7 al al NNP cord-309048-emmtplv3 105 8 . . . cord-309048-emmtplv3 106 1 ( ( -LRB- cord-309048-emmtplv3 106 2 1999 1999 CD cord-309048-emmtplv3 106 3 ) ) -RRB- cord-309048-emmtplv3 106 4 displayed display VBD cord-309048-emmtplv3 106 5 peptides peptide NNS cord-309048-emmtplv3 106 6 of of IN cord-309048-emmtplv3 106 7 either either DT cord-309048-emmtplv3 106 8 10 10 CD cord-309048-emmtplv3 106 9 or or CC cord-309048-emmtplv3 106 10 15 15 CD cord-309048-emmtplv3 106 11 amino amino NN cord-309048-emmtplv3 106 12 acids acid NNS cord-309048-emmtplv3 106 13 from from IN cord-309048-emmtplv3 106 14 the the DT cord-309048-emmtplv3 106 15 spike spike NN cord-309048-emmtplv3 106 16 protein protein NN cord-309048-emmtplv3 106 17 of of IN cord-309048-emmtplv3 106 18 the the DT cord-309048-emmtplv3 106 19 coronavirus coronavirus NN cord-309048-emmtplv3 106 20 murine murine JJ cord-309048-emmtplv3 106 21 hepatitis hepatitis NN cord-309048-emmtplv3 106 22 virus virus NN cord-309048-emmtplv3 106 23 on on IN cord-309048-emmtplv3 106 24 the the DT cord-309048-emmtplv3 106 25 surface surface NN cord-309048-emmtplv3 106 26 of of IN cord-309048-emmtplv3 106 27 assembled assemble VBN cord-309048-emmtplv3 106 28 particles particle NNS cord-309048-emmtplv3 106 29 . . . cord-309048-emmtplv3 107 1 When when WRB cord-309048-emmtplv3 107 2 purified purify VBN cord-309048-emmtplv3 107 3 virions virion NNS cord-309048-emmtplv3 107 4 were be VBD cord-309048-emmtplv3 107 5 used use VBN cord-309048-emmtplv3 107 6 to to TO cord-309048-emmtplv3 107 7 immunize immunize VB cord-309048-emmtplv3 107 8 mice mouse NNS cord-309048-emmtplv3 107 9 , , , cord-309048-emmtplv3 107 10 animals animal NNS cord-309048-emmtplv3 107 11 with with IN cord-309048-emmtplv3 107 12 high high JJ cord-309048-emmtplv3 107 13 antibody antibody NN cord-309048-emmtplv3 107 14 titers titer NNS cord-309048-emmtplv3 107 15 were be VBD cord-309048-emmtplv3 107 16 protected protect VBN cord-309048-emmtplv3 107 17 from from IN cord-309048-emmtplv3 107 18 subsequent subsequent JJ cord-309048-emmtplv3 107 19 challenge challenge NN cord-309048-emmtplv3 107 20 with with IN cord-309048-emmtplv3 107 21 infectious infectious JJ cord-309048-emmtplv3 107 22 murine murine JJ cord-309048-emmtplv3 107 23 hepatitis hepatitis NN cord-309048-emmtplv3 107 24 virus virus NN cord-309048-emmtplv3 107 25 . . . cord-309048-emmtplv3 108 1 This this DT cord-309048-emmtplv3 108 2 was be VBD cord-309048-emmtplv3 108 3 a a DT cord-309048-emmtplv3 108 4 highly highly RB cord-309048-emmtplv3 108 5 significant significant JJ cord-309048-emmtplv3 108 6 result result NN cord-309048-emmtplv3 108 7 as as IN cord-309048-emmtplv3 108 8 it -PRON- PRP cord-309048-emmtplv3 108 9 showed show VBD cord-309048-emmtplv3 108 10 , , , cord-309048-emmtplv3 108 11 for for IN cord-309048-emmtplv3 108 12 the the DT cord-309048-emmtplv3 108 13 first first JJ cord-309048-emmtplv3 108 14 time time NN cord-309048-emmtplv3 108 15 , , , cord-309048-emmtplv3 108 16 that that IN cord-309048-emmtplv3 108 17 TMV TMV NNP cord-309048-emmtplv3 108 18 particles particle NNS cord-309048-emmtplv3 108 19 expressing express VBG cord-309048-emmtplv3 108 20 a a DT cord-309048-emmtplv3 108 21 foreign foreign JJ cord-309048-emmtplv3 108 22 epitope epitope NN cord-309048-emmtplv3 108 23 could could MD cord-309048-emmtplv3 108 24 act act VB cord-309048-emmtplv3 108 25 as as IN cord-309048-emmtplv3 108 26 effective effective JJ cord-309048-emmtplv3 108 27 candidate candidate NN cord-309048-emmtplv3 108 28 vaccines vaccine NNS cord-309048-emmtplv3 108 29 . . . cord-309048-emmtplv3 109 1 It -PRON- PRP cord-309048-emmtplv3 109 2 also also RB cord-309048-emmtplv3 109 3 cemented cement VBD cord-309048-emmtplv3 109 4 the the DT cord-309048-emmtplv3 109 5 idea idea NN cord-309048-emmtplv3 109 6 that that IN cord-309048-emmtplv3 109 7 modified modify VBN cord-309048-emmtplv3 109 8 plant plant NN cord-309048-emmtplv3 109 9 virus virus NN cord-309048-emmtplv3 109 10 particles particle NNS cord-309048-emmtplv3 109 11 can can MD cord-309048-emmtplv3 109 12 act act VB cord-309048-emmtplv3 109 13 as as IN cord-309048-emmtplv3 109 14 candidate candidate NN cord-309048-emmtplv3 109 15 vaccines vaccine NNS cord-309048-emmtplv3 109 16 as as IN cord-309048-emmtplv3 109 17 originally originally RB cord-309048-emmtplv3 109 18 demonstrated demonstrate VBN cord-309048-emmtplv3 109 19 with with IN cord-309048-emmtplv3 109 20 cowpea cowpea NNP cord-309048-emmtplv3 109 21 mosaic mosaic NNP cord-309048-emmtplv3 109 22 virus virus NN cord-309048-emmtplv3 109 23 ( ( -LRB- cord-309048-emmtplv3 109 24 Dalsgaard Dalsgaard NNP cord-309048-emmtplv3 109 25 et et NNP cord-309048-emmtplv3 109 26 al al NNP cord-309048-emmtplv3 109 27 . . NNP cord-309048-emmtplv3 109 28 , , , cord-309048-emmtplv3 109 29 1997 1997 CD cord-309048-emmtplv3 109 30 ) ) -RRB- cord-309048-emmtplv3 109 31 . . . cord-309048-emmtplv3 110 1 Subsequently subsequently RB cord-309048-emmtplv3 110 2 , , , cord-309048-emmtplv3 110 3 Staczek Staczek NNP cord-309048-emmtplv3 110 4 et et NNP cord-309048-emmtplv3 110 5 al al NNP cord-309048-emmtplv3 110 6 . . . cord-309048-emmtplv3 111 1 ( ( -LRB- cord-309048-emmtplv3 111 2 2000 2000 CD cord-309048-emmtplv3 111 3 ) ) -RRB- cord-309048-emmtplv3 111 4 demonstrated demonstrate VBD cord-309048-emmtplv3 111 5 protection protection NN cord-309048-emmtplv3 111 6 using use VBG cord-309048-emmtplv3 111 7 an an DT cord-309048-emmtplv3 111 8 epitope epitope NN cord-309048-emmtplv3 111 9 from from IN cord-309048-emmtplv3 111 10 the the DT cord-309048-emmtplv3 111 11 outer outer JJ cord-309048-emmtplv3 111 12 membrane membrane NN cord-309048-emmtplv3 111 13 protein protein NN cord-309048-emmtplv3 111 14 F F NNP cord-309048-emmtplv3 111 15 of of IN cord-309048-emmtplv3 111 16 Pseudomonas Pseudomonas NNP cord-309048-emmtplv3 111 17 aeruginosa aeruginosa NN cord-309048-emmtplv3 111 18 expressed express VBN cord-309048-emmtplv3 111 19 at at IN cord-309048-emmtplv3 111 20 the the DT cord-309048-emmtplv3 111 21 same same JJ cord-309048-emmtplv3 111 22 site site NN cord-309048-emmtplv3 111 23 in in IN cord-309048-emmtplv3 111 24 the the DT cord-309048-emmtplv3 111 25 virus virus NN cord-309048-emmtplv3 111 26 particles particle NNS cord-309048-emmtplv3 111 27 , , , cord-309048-emmtplv3 111 28 and and CC cord-309048-emmtplv3 111 29 , , , cord-309048-emmtplv3 111 30 more more RBR cord-309048-emmtplv3 111 31 recently recently RB cord-309048-emmtplv3 111 32 , , , cord-309048-emmtplv3 111 33 Petukhova Petukhova NNP cord-309048-emmtplv3 111 34 et et NNP cord-309048-emmtplv3 111 35 al al NNP cord-309048-emmtplv3 111 36 . . . cord-309048-emmtplv3 112 1 ( ( -LRB- cord-309048-emmtplv3 112 2 2013 2013 CD cord-309048-emmtplv3 112 3 ) ) -RRB- cord-309048-emmtplv3 112 4 were be VBD cord-309048-emmtplv3 112 5 able able JJ cord-309048-emmtplv3 112 6 to to TO cord-309048-emmtplv3 112 7 demonstrate demonstrate VB cord-309048-emmtplv3 112 8 protective protective JJ cord-309048-emmtplv3 112 9 immunity immunity NN cord-309048-emmtplv3 112 10 in in IN cord-309048-emmtplv3 112 11 mice mouse NNS cord-309048-emmtplv3 112 12 using use VBG cord-309048-emmtplv3 112 13 TMV TMV NNP cord-309048-emmtplv3 112 14 particles particle NNS cord-309048-emmtplv3 112 15 displaying display VBG cord-309048-emmtplv3 112 16 the the DT cord-309048-emmtplv3 112 17 influenza influenza NN cord-309048-emmtplv3 112 18 virus virus NN cord-309048-emmtplv3 112 19 M2e m2e CD cord-309048-emmtplv3 112 20 epitope epitope NN cord-309048-emmtplv3 112 21 at at IN cord-309048-emmtplv3 112 22 a a DT cord-309048-emmtplv3 112 23 site site NN cord-309048-emmtplv3 112 24 near near IN cord-309048-emmtplv3 112 25 the the DT cord-309048-emmtplv3 112 26 C C NNP cord-309048-emmtplv3 112 27 - - HYPH cord-309048-emmtplv3 112 28 terminus terminus NN cord-309048-emmtplv3 112 29 of of IN cord-309048-emmtplv3 112 30 the the DT cord-309048-emmtplv3 112 31 CP cp NN cord-309048-emmtplv3 112 32 . . . cord-309048-emmtplv3 113 1 Despite despite IN cord-309048-emmtplv3 113 2 these these DT cord-309048-emmtplv3 113 3 successes success NNS cord-309048-emmtplv3 113 4 , , , cord-309048-emmtplv3 113 5 it -PRON- PRP cord-309048-emmtplv3 113 6 is be VBZ cord-309048-emmtplv3 113 7 reasonable reasonable JJ cord-309048-emmtplv3 113 8 to to TO cord-309048-emmtplv3 113 9 conclude conclude VB cord-309048-emmtplv3 113 10 that that IN cord-309048-emmtplv3 113 11 the the DT cord-309048-emmtplv3 113 12 direct direct JJ cord-309048-emmtplv3 113 13 fusion fusion NN cord-309048-emmtplv3 113 14 of of IN cord-309048-emmtplv3 113 15 peptides peptide NNS cord-309048-emmtplv3 113 16 at at IN cord-309048-emmtplv3 113 17 or or CC cord-309048-emmtplv3 113 18 near near IN cord-309048-emmtplv3 113 19 the the DT cord-309048-emmtplv3 113 20 C c NN cord-309048-emmtplv3 113 21 - - HYPH cord-309048-emmtplv3 113 22 terminus terminus NN cord-309048-emmtplv3 113 23 , , , cord-309048-emmtplv3 113 24 or or CC cord-309048-emmtplv3 113 25 at at IN cord-309048-emmtplv3 113 26 an an DT cord-309048-emmtplv3 113 27 exposed expose VBN cord-309048-emmtplv3 113 28 loop loop NN cord-309048-emmtplv3 113 29 within within IN cord-309048-emmtplv3 113 30 it -PRON- PRP cord-309048-emmtplv3 113 31 , , , cord-309048-emmtplv3 113 32 imposes impose VBZ cord-309048-emmtplv3 113 33 severe severe JJ cord-309048-emmtplv3 113 34 limitations limitation NNS cord-309048-emmtplv3 113 35 on on IN cord-309048-emmtplv3 113 36 the the DT cord-309048-emmtplv3 113 37 size size NN cord-309048-emmtplv3 113 38 of of IN cord-309048-emmtplv3 113 39 sequence sequence NN cord-309048-emmtplv3 113 40 that that WDT cord-309048-emmtplv3 113 41 can can MD cord-309048-emmtplv3 113 42 be be VB cord-309048-emmtplv3 113 43 displayed display VBN cord-309048-emmtplv3 113 44 on on IN cord-309048-emmtplv3 113 45 assembled assemble VBN cord-309048-emmtplv3 113 46 particles particle NNS cord-309048-emmtplv3 113 47 , , , cord-309048-emmtplv3 113 48 probably probably RB cord-309048-emmtplv3 113 49 a a DT cord-309048-emmtplv3 113 50 consequence consequence NN cord-309048-emmtplv3 113 51 of of IN cord-309048-emmtplv3 113 52 the the DT cord-309048-emmtplv3 113 53 close close RB cord-309048-emmtplv3 113 54 - - HYPH cord-309048-emmtplv3 113 55 packed pack VBN cord-309048-emmtplv3 113 56 nature nature NN cord-309048-emmtplv3 113 57 of of IN cord-309048-emmtplv3 113 58 the the DT cord-309048-emmtplv3 113 59 subunits subunit NNS cord-309048-emmtplv3 113 60 . . . cord-309048-emmtplv3 114 1 This this DT cord-309048-emmtplv3 114 2 sparked spark VBD cord-309048-emmtplv3 114 3 the the DT cord-309048-emmtplv3 114 4 development development NN cord-309048-emmtplv3 114 5 of of IN cord-309048-emmtplv3 114 6 a a DT cord-309048-emmtplv3 114 7 number number NN cord-309048-emmtplv3 114 8 of of IN cord-309048-emmtplv3 114 9 approaches approach NNS cord-309048-emmtplv3 114 10 to to IN cord-309048-emmtplv3 114 11 increasing increase VBG cord-309048-emmtplv3 114 12 the the DT cord-309048-emmtplv3 114 13 size size NN cord-309048-emmtplv3 114 14 of of IN cord-309048-emmtplv3 114 15 peptides peptide NNS cord-309048-emmtplv3 114 16 that that WDT cord-309048-emmtplv3 114 17 can can MD cord-309048-emmtplv3 114 18 be be VB cord-309048-emmtplv3 114 19 presented present VBN cord-309048-emmtplv3 114 20 by by IN cord-309048-emmtplv3 114 21 modifying modify VBG cord-309048-emmtplv3 114 22 the the DT cord-309048-emmtplv3 114 23 C C NNP cord-309048-emmtplv3 114 24 - - HYPH cord-309048-emmtplv3 114 25 terminus terminus NN cord-309048-emmtplv3 114 26 of of IN cord-309048-emmtplv3 114 27 the the DT cord-309048-emmtplv3 114 28 CP cp NN cord-309048-emmtplv3 114 29 . . . cord-309048-emmtplv3 115 1 By by IN cord-309048-emmtplv3 115 2 deleting delete VBG cord-309048-emmtplv3 115 3 four four CD cord-309048-emmtplv3 115 4 to to TO cord-309048-emmtplv3 115 5 six six CD cord-309048-emmtplv3 115 6 amino amino NN cord-309048-emmtplv3 115 7 acids acid NNS cord-309048-emmtplv3 115 8 from from IN cord-309048-emmtplv3 115 9 the the DT cord-309048-emmtplv3 115 10 C C NNP cord-309048-emmtplv3 115 11 - - HYPH cord-309048-emmtplv3 115 12 terminus terminus NN cord-309048-emmtplv3 115 13 amino amino NN cord-309048-emmtplv3 115 14 acids acid NNS cord-309048-emmtplv3 115 15 of of IN cord-309048-emmtplv3 115 16 the the DT cord-309048-emmtplv3 115 17 CP cp NN cord-309048-emmtplv3 115 18 , , , cord-309048-emmtplv3 115 19 Jiang Jiang NNP cord-309048-emmtplv3 115 20 et et FW cord-309048-emmtplv3 115 21 al al NNP cord-309048-emmtplv3 115 22 . . . cord-309048-emmtplv3 116 1 ( ( -LRB- cord-309048-emmtplv3 116 2 2006 2006 CD cord-309048-emmtplv3 116 3 ) ) -RRB- cord-309048-emmtplv3 116 4 were be VBD cord-309048-emmtplv3 116 5 able able JJ cord-309048-emmtplv3 116 6 to to TO cord-309048-emmtplv3 116 7 present present VB cord-309048-emmtplv3 116 8 a a DT cord-309048-emmtplv3 116 9 peptide peptide NN cord-309048-emmtplv3 116 10 of of IN cord-309048-emmtplv3 116 11 25 25 CD cord-309048-emmtplv3 116 12 amino amino JJ cord-309048-emmtplv3 116 13 acids acid NNS cord-309048-emmtplv3 116 14 from from IN cord-309048-emmtplv3 116 15 FMDV FMDV NNP cord-309048-emmtplv3 116 16 VP1 vp1 NN cord-309048-emmtplv3 116 17 on on IN cord-309048-emmtplv3 116 18 the the DT cord-309048-emmtplv3 116 19 virus virus NN cord-309048-emmtplv3 116 20 surface surface NN cord-309048-emmtplv3 116 21 - - : cord-309048-emmtplv3 116 22 a a DT cord-309048-emmtplv3 116 23 modest modest JJ cord-309048-emmtplv3 116 24 increase increase NN cord-309048-emmtplv3 116 25 over over IN cord-309048-emmtplv3 116 26 the the DT cord-309048-emmtplv3 116 27 previously previously RB cord-309048-emmtplv3 116 28 reported report VBN cord-309048-emmtplv3 116 29 maximum maximum NN cord-309048-emmtplv3 116 30 . . . cord-309048-emmtplv3 117 1 An an DT cord-309048-emmtplv3 117 2 alternative alternative JJ cord-309048-emmtplv3 117 3 approach approach NN cord-309048-emmtplv3 117 4 has have VBZ cord-309048-emmtplv3 117 5 been be VBN cord-309048-emmtplv3 117 6 to to TO cord-309048-emmtplv3 117 7 insert insert VB cord-309048-emmtplv3 117 8 linker linker NN cord-309048-emmtplv3 117 9 sequences sequence NNS cord-309048-emmtplv3 117 10 between between IN cord-309048-emmtplv3 117 11 the the DT cord-309048-emmtplv3 117 12 C C NNP cord-309048-emmtplv3 117 13 - - HYPH cord-309048-emmtplv3 117 14 terminus terminus NN cord-309048-emmtplv3 117 15 and and CC cord-309048-emmtplv3 117 16 the the DT cord-309048-emmtplv3 117 17 sequence sequence NN cord-309048-emmtplv3 117 18 to to TO cord-309048-emmtplv3 117 19 be be VB cord-309048-emmtplv3 117 20 presented present VBN cord-309048-emmtplv3 117 21 . . . cord-309048-emmtplv3 118 1 By by IN cord-309048-emmtplv3 118 2 incorporating incorporate VBG cord-309048-emmtplv3 118 3 a a DT cord-309048-emmtplv3 118 4 15-amino 15-amino CD cord-309048-emmtplv3 118 5 acid acid NN cord-309048-emmtplv3 118 6 linker linker NN cord-309048-emmtplv3 118 7 , , , cord-309048-emmtplv3 118 8 Werner Werner NNP cord-309048-emmtplv3 118 9 et et NNP cord-309048-emmtplv3 118 10 al al NNP cord-309048-emmtplv3 118 11 . . . cord-309048-emmtplv3 119 1 ( ( -LRB- cord-309048-emmtplv3 119 2 2006 2006 CD cord-309048-emmtplv3 119 3 ) ) -RRB- cord-309048-emmtplv3 119 4 were be VBD cord-309048-emmtplv3 119 5 able able JJ cord-309048-emmtplv3 119 6 to to TO cord-309048-emmtplv3 119 7 display display VB cord-309048-emmtplv3 119 8 a a DT cord-309048-emmtplv3 119 9 133-amino 133-amino CD cord-309048-emmtplv3 119 10 acid acid NN cord-309048-emmtplv3 119 11 segment segment NN cord-309048-emmtplv3 119 12 of of IN cord-309048-emmtplv3 119 13 protein protein NN cord-309048-emmtplv3 119 14 A A NNP cord-309048-emmtplv3 119 15 , , , cord-309048-emmtplv3 119 16 on on IN cord-309048-emmtplv3 119 17 the the DT cord-309048-emmtplv3 119 18 surface surface NN cord-309048-emmtplv3 119 19 of of IN cord-309048-emmtplv3 119 20 particles particle NNS cord-309048-emmtplv3 119 21 of of IN cord-309048-emmtplv3 119 22 a a DT cord-309048-emmtplv3 119 23 close close JJ cord-309048-emmtplv3 119 24 relative relative NN cord-309048-emmtplv3 119 25 of of IN cord-309048-emmtplv3 119 26 TMV TMV NNP cord-309048-emmtplv3 119 27 , , , cord-309048-emmtplv3 119 28 the the DT cord-309048-emmtplv3 119 29 tobamovirus tobamovirus NNP cord-309048-emmtplv3 119 30 turnip turnip NN cord-309048-emmtplv3 119 31 vein vein NN cord-309048-emmtplv3 119 32 clearing clear VBG cord-309048-emmtplv3 119 33 virus virus NN cord-309048-emmtplv3 119 34 - - : cord-309048-emmtplv3 119 35 a a DT cord-309048-emmtplv3 119 36 dramatic dramatic JJ cord-309048-emmtplv3 119 37 increase increase NN cord-309048-emmtplv3 119 38 over over IN cord-309048-emmtplv3 119 39 what what WP cord-309048-emmtplv3 119 40 had have VBD cord-309048-emmtplv3 119 41 been be VBN cord-309048-emmtplv3 119 42 reported report VBN cord-309048-emmtplv3 119 43 previously previously RB cord-309048-emmtplv3 119 44 . . . cord-309048-emmtplv3 120 1 The the DT cord-309048-emmtplv3 120 2 protein protein NN cord-309048-emmtplv3 120 3 A a DT cord-309048-emmtplv3 120 4 fragment fragment NN cord-309048-emmtplv3 120 5 could could MD cord-309048-emmtplv3 120 6 bind bind VB cord-309048-emmtplv3 120 7 IgG igg NN cord-309048-emmtplv3 120 8 indicating indicate VBG cord-309048-emmtplv3 120 9 that that IN cord-309048-emmtplv3 120 10 the the DT cord-309048-emmtplv3 120 11 modified modify VBN cord-309048-emmtplv3 120 12 virus virus NN cord-309048-emmtplv3 120 13 particles particle NNS cord-309048-emmtplv3 120 14 could could MD cord-309048-emmtplv3 120 15 potentially potentially RB cord-309048-emmtplv3 120 16 be be VB cord-309048-emmtplv3 120 17 used use VBN cord-309048-emmtplv3 120 18 to to TO cord-309048-emmtplv3 120 19 purify purify VB cord-309048-emmtplv3 120 20 antibodies antibody NNS cord-309048-emmtplv3 120 21 . . . cord-309048-emmtplv3 121 1 Using use VBG cord-309048-emmtplv3 121 2 a a DT cord-309048-emmtplv3 121 3 similar similar JJ cord-309048-emmtplv3 121 4 linker linker NN cord-309048-emmtplv3 121 5 strategy strategy NN cord-309048-emmtplv3 121 6 , , , cord-309048-emmtplv3 121 7 Frolova Frolova NNP cord-309048-emmtplv3 121 8 et et NNP cord-309048-emmtplv3 121 9 al al NNP cord-309048-emmtplv3 121 10 . . . cord-309048-emmtplv3 122 1 ( ( -LRB- cord-309048-emmtplv3 122 2 2010 2010 CD cord-309048-emmtplv3 122 3 ) ) -RRB- cord-309048-emmtplv3 122 4 were be VBD cord-309048-emmtplv3 122 5 able able JJ cord-309048-emmtplv3 122 6 to to TO cord-309048-emmtplv3 122 7 display display VB cord-309048-emmtplv3 122 8 trastuzumab trastuzumab NNS cord-309048-emmtplv3 122 9 - - HYPH cord-309048-emmtplv3 122 10 binding bind VBG cord-309048-emmtplv3 122 11 peptides peptide NNS cord-309048-emmtplv3 122 12 of of IN cord-309048-emmtplv3 122 13 HER2 HER2 NNP cord-309048-emmtplv3 122 14 / / SYM cord-309048-emmtplv3 122 15 neu neu NNP cord-309048-emmtplv3 122 16 on on IN cord-309048-emmtplv3 122 17 the the DT cord-309048-emmtplv3 122 18 surface surface NN cord-309048-emmtplv3 122 19 of of IN cord-309048-emmtplv3 122 20 virus virus NN cord-309048-emmtplv3 122 21 particles particle NNS cord-309048-emmtplv3 122 22 and and CC cord-309048-emmtplv3 122 23 showed show VBD cord-309048-emmtplv3 122 24 that that IN cord-309048-emmtplv3 122 25 the the DT cord-309048-emmtplv3 122 26 peptides peptide NNS cord-309048-emmtplv3 122 27 retained retain VBD cord-309048-emmtplv3 122 28 their -PRON- PRP$ cord-309048-emmtplv3 122 29 trastuzumabbinding trastuzumabbinding NN cord-309048-emmtplv3 122 30 capacity capacity NN cord-309048-emmtplv3 122 31 . . . cord-309048-emmtplv3 123 1 The the DT cord-309048-emmtplv3 123 2 development development NN cord-309048-emmtplv3 123 3 of of IN cord-309048-emmtplv3 123 4 TMV TMV NNP cord-309048-emmtplv3 123 5 - - HYPH cord-309048-emmtplv3 123 6 based base VBN cord-309048-emmtplv3 123 7 systems system NNS cord-309048-emmtplv3 123 8 for for IN cord-309048-emmtplv3 123 9 the the DT cord-309048-emmtplv3 123 10 display display NN cord-309048-emmtplv3 123 11 of of IN cord-309048-emmtplv3 123 12 increasingly increasingly RB cord-309048-emmtplv3 123 13 large large JJ cord-309048-emmtplv3 123 14 peptides peptide NNS cord-309048-emmtplv3 123 15 has have VBZ cord-309048-emmtplv3 123 16 led lead VBN cord-309048-emmtplv3 123 17 to to IN cord-309048-emmtplv3 123 18 a a DT cord-309048-emmtplv3 123 19 number number NN cord-309048-emmtplv3 123 20 of of IN cord-309048-emmtplv3 123 21 detailed detailed JJ cord-309048-emmtplv3 123 22 immunological immunological JJ cord-309048-emmtplv3 123 23 studies study NNS cord-309048-emmtplv3 123 24 and and CC cord-309048-emmtplv3 123 25 the the DT cord-309048-emmtplv3 123 26 commercial commercial JJ cord-309048-emmtplv3 123 27 development development NN cord-309048-emmtplv3 123 28 of of IN cord-309048-emmtplv3 123 29 the the DT cord-309048-emmtplv3 123 30 technology technology NN cord-309048-emmtplv3 123 31 . . . cord-309048-emmtplv3 124 1 These these DT cord-309048-emmtplv3 124 2 aspects aspect NNS cord-309048-emmtplv3 124 3 are be VBP cord-309048-emmtplv3 124 4 beyond beyond IN cord-309048-emmtplv3 124 5 the the DT cord-309048-emmtplv3 124 6 scope scope NN cord-309048-emmtplv3 124 7 of of IN cord-309048-emmtplv3 124 8 this this DT cord-309048-emmtplv3 124 9 review review NN cord-309048-emmtplv3 124 10 and and CC cord-309048-emmtplv3 124 11 the the DT cord-309048-emmtplv3 124 12 reader reader NN cord-309048-emmtplv3 124 13 is be VBZ cord-309048-emmtplv3 124 14 referred refer VBN cord-309048-emmtplv3 124 15 to to IN cord-309048-emmtplv3 124 16 articles article NNS cord-309048-emmtplv3 124 17 by by IN cord-309048-emmtplv3 124 18 McCormick McCormick NNP cord-309048-emmtplv3 124 19 and and CC cord-309048-emmtplv3 124 20 Palmer Palmer NNP cord-309048-emmtplv3 124 21 ( ( -LRB- cord-309048-emmtplv3 124 22 2008 2008 CD cord-309048-emmtplv3 124 23 ) ) -RRB- cord-309048-emmtplv3 124 24 2017 2017 CD cord-309048-emmtplv3 124 25 ) ) -RRB- cord-309048-emmtplv3 124 26 for for IN cord-309048-emmtplv3 124 27 a a DT cord-309048-emmtplv3 124 28 detailed detailed JJ cord-309048-emmtplv3 124 29 discussion discussion NN cord-309048-emmtplv3 124 30 of of IN cord-309048-emmtplv3 124 31 progress progress NN cord-309048-emmtplv3 124 32 in in IN cord-309048-emmtplv3 124 33 these these DT cord-309048-emmtplv3 124 34 areas area NNS cord-309048-emmtplv3 124 35 . . . cord-309048-emmtplv3 125 1 The the DT cord-309048-emmtplv3 125 2 outer outer JJ cord-309048-emmtplv3 125 3 surface surface NN cord-309048-emmtplv3 125 4 of of IN cord-309048-emmtplv3 125 5 natural natural JJ cord-309048-emmtplv3 125 6 TMV TMV NNP cord-309048-emmtplv3 125 7 particles particle NNS cord-309048-emmtplv3 125 8 has have VBZ cord-309048-emmtplv3 125 9 relatively relatively RB cord-309048-emmtplv3 125 10 few few JJ cord-309048-emmtplv3 125 11 chemically chemically RB cord-309048-emmtplv3 125 12 reactive reactive JJ cord-309048-emmtplv3 125 13 amino amino NN cord-309048-emmtplv3 125 14 acids acid NNS cord-309048-emmtplv3 125 15 such such JJ cord-309048-emmtplv3 125 16 as as IN cord-309048-emmtplv3 125 17 cysteine cysteine NN cord-309048-emmtplv3 125 18 and and CC cord-309048-emmtplv3 125 19 lysine lysine NN cord-309048-emmtplv3 125 20 , , , cord-309048-emmtplv3 125 21 making make VBG cord-309048-emmtplv3 125 22 the the DT cord-309048-emmtplv3 125 23 chemical chemical JJ cord-309048-emmtplv3 125 24 functionalization functionalization NN cord-309048-emmtplv3 125 25 of of IN cord-309048-emmtplv3 125 26 such such JJ cord-309048-emmtplv3 125 27 particles particle NNS cord-309048-emmtplv3 125 28 problematic problematic JJ cord-309048-emmtplv3 125 29 . . . cord-309048-emmtplv3 126 1 However however RB cord-309048-emmtplv3 126 2 , , , cord-309048-emmtplv3 126 3 Schlick Schlick NNP cord-309048-emmtplv3 126 4 et et NNP cord-309048-emmtplv3 126 5 al al NNP cord-309048-emmtplv3 126 6 . . . cord-309048-emmtplv3 127 1 ( ( -LRB- cord-309048-emmtplv3 127 2 2005 2005 CD cord-309048-emmtplv3 127 3 ) ) -RRB- cord-309048-emmtplv3 127 4 reported report VBD cord-309048-emmtplv3 127 5 the the DT cord-309048-emmtplv3 127 6 derivatization derivatization NN cord-309048-emmtplv3 127 7 of of IN cord-309048-emmtplv3 127 8 exterior exterior NN cord-309048-emmtplv3 127 9 - - HYPH cord-309048-emmtplv3 127 10 exposed expose VBN cord-309048-emmtplv3 127 11 tyrosine tyrosine NN cord-309048-emmtplv3 127 12 residues residue NNS cord-309048-emmtplv3 127 13 with with IN cord-309048-emmtplv3 127 14 diazonium diazonium NN cord-309048-emmtplv3 127 15 salts salt NNS cord-309048-emmtplv3 127 16 , , , cord-309048-emmtplv3 127 17 resulting result VBG cord-309048-emmtplv3 127 18 in in IN cord-309048-emmtplv3 127 19 a a DT cord-309048-emmtplv3 127 20 conjugate conjugate NN cord-309048-emmtplv3 127 21 that that WDT cord-309048-emmtplv3 127 22 could could MD cord-309048-emmtplv3 127 23 react react VB cord-309048-emmtplv3 127 24 with with IN cord-309048-emmtplv3 127 25 a a DT cord-309048-emmtplv3 127 26 wide wide JJ cord-309048-emmtplv3 127 27 range range NN cord-309048-emmtplv3 127 28 of of IN cord-309048-emmtplv3 127 29 other other JJ cord-309048-emmtplv3 127 30 molecules molecule NNS cord-309048-emmtplv3 127 31 including include VBG cord-309048-emmtplv3 127 32 polyethylene polyethylene NN cord-309048-emmtplv3 127 33 glycol glycol NN cord-309048-emmtplv3 127 34 derivatives derivative NNS cord-309048-emmtplv3 127 35 . . . cord-309048-emmtplv3 128 1 To to TO cord-309048-emmtplv3 128 2 overcome overcome VB cord-309048-emmtplv3 128 3 the the DT cord-309048-emmtplv3 128 4 lack lack NN cord-309048-emmtplv3 128 5 of of IN cord-309048-emmtplv3 128 6 reactive reactive JJ cord-309048-emmtplv3 128 7 amino amino NN cord-309048-emmtplv3 128 8 acid acid NN cord-309048-emmtplv3 128 9 chains chain NNS cord-309048-emmtplv3 128 10 on on IN cord-309048-emmtplv3 128 11 the the DT cord-309048-emmtplv3 128 12 virus virus NN cord-309048-emmtplv3 128 13 surface surface NN cord-309048-emmtplv3 128 14 , , , cord-309048-emmtplv3 128 15 several several JJ cord-309048-emmtplv3 128 16 mutants mutant NNS cord-309048-emmtplv3 128 17 displaying display VBG cord-309048-emmtplv3 128 18 reactive reactive JJ cord-309048-emmtplv3 128 19 cysteine cysteine NN cord-309048-emmtplv3 128 20 or or CC cord-309048-emmtplv3 128 21 lysine lysine NN cord-309048-emmtplv3 128 22 residues residue NNS cord-309048-emmtplv3 128 23 on on IN cord-309048-emmtplv3 128 24 the the DT cord-309048-emmtplv3 128 25 solventexposed solventexpose VBN cord-309048-emmtplv3 128 26 exterior exterior NN cord-309048-emmtplv3 128 27 of of IN cord-309048-emmtplv3 128 28 the the DT cord-309048-emmtplv3 128 29 virus virus NN cord-309048-emmtplv3 128 30 have have VBP cord-309048-emmtplv3 128 31 been be VBN cord-309048-emmtplv3 128 32 made make VBN cord-309048-emmtplv3 128 33 , , , cord-309048-emmtplv3 128 34 allowing allow VBG cord-309048-emmtplv3 128 35 decoration decoration NN cord-309048-emmtplv3 128 36 via via IN cord-309048-emmtplv3 128 37 thiol thiol NN cord-309048-emmtplv3 128 38 - - HYPH cord-309048-emmtplv3 128 39 or or CC cord-309048-emmtplv3 128 40 amine amine NN cord-309048-emmtplv3 128 41 - - HYPH cord-309048-emmtplv3 128 42 selective selective JJ cord-309048-emmtplv3 128 43 chemistry chemistry NN cord-309048-emmtplv3 128 44 ( ( -LRB- cord-309048-emmtplv3 128 45 Demir Demir NNP cord-309048-emmtplv3 128 46 and and CC cord-309048-emmtplv3 128 47 Stowell Stowell NNP cord-309048-emmtplv3 128 48 , , , cord-309048-emmtplv3 128 49 2002 2002 CD cord-309048-emmtplv3 128 50 ; ; : cord-309048-emmtplv3 128 51 Geiger Geiger NNP cord-309048-emmtplv3 128 52 et et NNP cord-309048-emmtplv3 128 53 al al NNP cord-309048-emmtplv3 128 54 . . NNP cord-309048-emmtplv3 128 55 , , , cord-309048-emmtplv3 128 56 2013 2013 CD cord-309048-emmtplv3 128 57 ; ; : cord-309048-emmtplv3 129 1 Yi Yi NNP cord-309048-emmtplv3 129 2 et et FW cord-309048-emmtplv3 129 3 al al NNP cord-309048-emmtplv3 129 4 . . NNP cord-309048-emmtplv3 129 5 , , , cord-309048-emmtplv3 130 1 2005 2005 CD cord-309048-emmtplv3 131 1 Yi Yi NNP cord-309048-emmtplv3 131 2 et et FW cord-309048-emmtplv3 131 3 al al NNP cord-309048-emmtplv3 131 4 . . NNP cord-309048-emmtplv3 131 5 , , , cord-309048-emmtplv3 131 6 , , , cord-309048-emmtplv3 131 7 2007 2007 CD cord-309048-emmtplv3 131 8 . . . cord-309048-emmtplv3 132 1 However however RB cord-309048-emmtplv3 132 2 , , , cord-309048-emmtplv3 132 3 in in IN cord-309048-emmtplv3 132 4 several several JJ cord-309048-emmtplv3 132 5 cases case NNS cord-309048-emmtplv3 132 6 the the DT cord-309048-emmtplv3 132 7 presence presence NN cord-309048-emmtplv3 132 8 of of IN cord-309048-emmtplv3 132 9 these these DT cord-309048-emmtplv3 132 10 added add VBN cord-309048-emmtplv3 132 11 residues residue NNS cord-309048-emmtplv3 132 12 adversely adversely RB cord-309048-emmtplv3 132 13 affected affect VBD cord-309048-emmtplv3 132 14 virus virus NN cord-309048-emmtplv3 132 15 yield yield NN cord-309048-emmtplv3 132 16 . . . cord-309048-emmtplv3 133 1 To to TO cord-309048-emmtplv3 133 2 address address VB cord-309048-emmtplv3 133 3 this this DT cord-309048-emmtplv3 133 4 , , , cord-309048-emmtplv3 133 5 Smith Smith NNP cord-309048-emmtplv3 133 6 et et NNP cord-309048-emmtplv3 133 7 al al NNP cord-309048-emmtplv3 133 8 . . . cord-309048-emmtplv3 134 1 ( ( -LRB- cord-309048-emmtplv3 134 2 2006 2006 CD cord-309048-emmtplv3 134 3 ) ) -RRB- cord-309048-emmtplv3 134 4 screened screen VBD cord-309048-emmtplv3 134 5 a a DT cord-309048-emmtplv3 134 6 collection collection NN cord-309048-emmtplv3 134 7 of of IN cord-309048-emmtplv3 134 8 random random JJ cord-309048-emmtplv3 134 9 TMV TMV NNP cord-309048-emmtplv3 134 10 mutants mutant NNS cord-309048-emmtplv3 134 11 that that WDT cord-309048-emmtplv3 134 12 had have VBD cord-309048-emmtplv3 134 13 additional additional JJ cord-309048-emmtplv3 134 14 amino amino JJ cord-309048-emmtplv3 134 15 acids acid NNS cord-309048-emmtplv3 134 16 , , , cord-309048-emmtplv3 134 17 including include VBG cord-309048-emmtplv3 134 18 a a DT cord-309048-emmtplv3 134 19 single single JJ cord-309048-emmtplv3 134 20 lysine lysine NN cord-309048-emmtplv3 134 21 , , , cord-309048-emmtplv3 134 22 inserted insert VBN cord-309048-emmtplv3 134 23 near near IN cord-309048-emmtplv3 134 24 the the DT cord-309048-emmtplv3 134 25 N n CD cord-309048-emmtplv3 134 26 - - HYPH cord-309048-emmtplv3 134 27 terminus terminus NN cord-309048-emmtplv3 134 28 of of IN cord-309048-emmtplv3 134 29 the the DT cord-309048-emmtplv3 134 30 CP cp NN cord-309048-emmtplv3 134 31 . . . cord-309048-emmtplv3 135 1 By by IN cord-309048-emmtplv3 135 2 selecting select VBG cord-309048-emmtplv3 135 3 those those DT cord-309048-emmtplv3 135 4 mutants mutant NNS cord-309048-emmtplv3 135 5 that that WDT cord-309048-emmtplv3 135 6 grew grow VBD cord-309048-emmtplv3 135 7 well well RB cord-309048-emmtplv3 135 8 , , , cord-309048-emmtplv3 135 9 the the DT cord-309048-emmtplv3 135 10 authors author NNS cord-309048-emmtplv3 135 11 were be VBD cord-309048-emmtplv3 135 12 able able JJ cord-309048-emmtplv3 135 13 to to TO cord-309048-emmtplv3 135 14 identify identify VB cord-309048-emmtplv3 135 15 a a DT cord-309048-emmtplv3 135 16 mutant mutant JJ cord-309048-emmtplv3 135 17 suitable suitable NN cord-309048-emmtplv3 135 18 for for IN cord-309048-emmtplv3 135 19 the the DT cord-309048-emmtplv3 135 20 chemical chemical NN cord-309048-emmtplv3 135 21 coupling coupling NN cord-309048-emmtplv3 135 22 of of IN cord-309048-emmtplv3 135 23 a a DT cord-309048-emmtplv3 135 24 variety variety NN cord-309048-emmtplv3 135 25 of of IN cord-309048-emmtplv3 135 26 peptides peptide NNS cord-309048-emmtplv3 135 27 ( ( -LRB- cord-309048-emmtplv3 135 28 McCormick McCormick NNP cord-309048-emmtplv3 135 29 and and CC cord-309048-emmtplv3 135 30 Palmer Palmer NNP cord-309048-emmtplv3 135 31 , , , cord-309048-emmtplv3 135 32 2008 2008 CD cord-309048-emmtplv3 135 33 ) ) -RRB- cord-309048-emmtplv3 135 34 . . . cord-309048-emmtplv3 136 1 The the DT cord-309048-emmtplv3 136 2 external external JJ cord-309048-emmtplv3 136 3 surface surface NN cord-309048-emmtplv3 136 4 of of IN cord-309048-emmtplv3 136 5 TMV TMV NNP cord-309048-emmtplv3 136 6 has have VBZ cord-309048-emmtplv3 136 7 also also RB cord-309048-emmtplv3 136 8 been be VBN cord-309048-emmtplv3 136 9 used use VBN cord-309048-emmtplv3 136 10 as as IN cord-309048-emmtplv3 136 11 a a DT cord-309048-emmtplv3 136 12 template template NN cord-309048-emmtplv3 136 13 for for IN cord-309048-emmtplv3 136 14 a a DT cord-309048-emmtplv3 136 15 diversity diversity NN cord-309048-emmtplv3 136 16 of of IN cord-309048-emmtplv3 136 17 chemical chemical JJ cord-309048-emmtplv3 136 18 deposition deposition NN cord-309048-emmtplv3 136 19 reactions reaction NNS cord-309048-emmtplv3 136 20 . . . cord-309048-emmtplv3 137 1 These these DT cord-309048-emmtplv3 137 2 include include VBP cord-309048-emmtplv3 137 3 the the DT cord-309048-emmtplv3 137 4 cocrystallization cocrystallization NN cord-309048-emmtplv3 137 5 of of IN cord-309048-emmtplv3 137 6 CdS CdS NNPS cord-309048-emmtplv3 137 7 and and CC cord-309048-emmtplv3 137 8 PbS pbs NN cord-309048-emmtplv3 137 9 , , , cord-309048-emmtplv3 137 10 oxidative oxidative JJ cord-309048-emmtplv3 137 11 hydrolysis hydrolysis NN cord-309048-emmtplv3 137 12 yielding yield VBG cord-309048-emmtplv3 137 13 iron iron NN cord-309048-emmtplv3 137 14 oxides oxide NNS cord-309048-emmtplv3 137 15 , , , cord-309048-emmtplv3 137 16 condensation condensation NN cord-309048-emmtplv3 137 17 of of IN cord-309048-emmtplv3 137 18 SiO SiO NNP cord-309048-emmtplv3 137 19 2 2 CD cord-309048-emmtplv3 137 20 , , , cord-309048-emmtplv3 137 21 and and CC cord-309048-emmtplv3 137 22 ( ( -LRB- cord-309048-emmtplv3 137 23 NH NH NNP cord-309048-emmtplv3 137 24 4 4 CD cord-309048-emmtplv3 137 25 ) ) -RRB- cord-309048-emmtplv3 137 26 2 2 CD cord-309048-emmtplv3 137 27 CO co NN cord-309048-emmtplv3 137 28 3 3 CD cord-309048-emmtplv3 137 29 decomposition decomposition NN cord-309048-emmtplv3 137 30 producing produce VBG cord-309048-emmtplv3 137 31 electrocatalytically electrocatalytically RB cord-309048-emmtplv3 137 32 active active JJ cord-309048-emmtplv3 138 1 Co Co NNP cord-309048-emmtplv3 139 1 3 3 CD cord-309048-emmtplv3 139 2 O o NN cord-309048-emmtplv3 139 3 4 4 CD cord-309048-emmtplv3 140 1 ( ( -LRB- cord-309048-emmtplv3 140 2 Fowler Fowler NNP cord-309048-emmtplv3 140 3 et et NNP cord-309048-emmtplv3 140 4 al al NNP cord-309048-emmtplv3 140 5 . . NNP cord-309048-emmtplv3 140 6 , , , cord-309048-emmtplv3 140 7 2001 2001 CD cord-309048-emmtplv3 140 8 ; ; : cord-309048-emmtplv3 140 9 Schenk Schenk NNP cord-309048-emmtplv3 140 10 et et NNP cord-309048-emmtplv3 140 11 al al NNP cord-309048-emmtplv3 140 12 . . NNP cord-309048-emmtplv3 140 13 , , , cord-309048-emmtplv3 140 14 2017 2017 CD cord-309048-emmtplv3 140 15 ; ; : cord-309048-emmtplv3 140 16 Shenton Shenton NNP cord-309048-emmtplv3 140 17 et et NNP cord-309048-emmtplv3 140 18 al al NNP cord-309048-emmtplv3 140 19 . . NNP cord-309048-emmtplv3 140 20 , , , cord-309048-emmtplv3 140 21 1999 1999 CD cord-309048-emmtplv3 140 22 ) ) -RRB- cord-309048-emmtplv3 140 23 . . . cord-309048-emmtplv3 141 1 Such such JJ cord-309048-emmtplv3 141 2 deposition deposition NN cord-309048-emmtplv3 141 3 is be VBZ cord-309048-emmtplv3 141 4 often often RB cord-309048-emmtplv3 141 5 carried carry VBN cord-309048-emmtplv3 141 6 out out RP cord-309048-emmtplv3 141 7 using use VBG cord-309048-emmtplv3 141 8 particles particle NNS cord-309048-emmtplv3 141 9 displaying display VBG cord-309048-emmtplv3 141 10 mineralizationdirecting mineralizationdirecte VBG cord-309048-emmtplv3 141 11 peptides peptide NNS cord-309048-emmtplv3 141 12 either either CC cord-309048-emmtplv3 141 13 genetically genetically RB cord-309048-emmtplv3 141 14 or or CC cord-309048-emmtplv3 141 15 chemically chemically RB cord-309048-emmtplv3 141 16 attached attach VBN cord-309048-emmtplv3 141 17 to to IN cord-309048-emmtplv3 141 18 the the DT cord-309048-emmtplv3 141 19 particle particle NN cord-309048-emmtplv3 141 20 surface surface NN cord-309048-emmtplv3 141 21 ( ( -LRB- cord-309048-emmtplv3 141 22 Altintoprak Altintoprak NNPS cord-309048-emmtplv3 141 23 et et NNP cord-309048-emmtplv3 141 24 al al NNP cord-309048-emmtplv3 141 25 . . NNP cord-309048-emmtplv3 141 26 , , , cord-309048-emmtplv3 141 27 2015 2015 CD cord-309048-emmtplv3 141 28 ; ; : cord-309048-emmtplv3 141 29 Love Love NNP cord-309048-emmtplv3 141 30 et et NNP cord-309048-emmtplv3 141 31 al al NNP cord-309048-emmtplv3 141 32 . . NNP cord-309048-emmtplv3 141 33 , , , cord-309048-emmtplv3 141 34 2015 2015 CD cord-309048-emmtplv3 141 35 ) ) -RRB- cord-309048-emmtplv3 141 36 . . . cord-309048-emmtplv3 142 1 In in IN cord-309048-emmtplv3 142 2 some some DT cord-309048-emmtplv3 142 3 cases case NNS cord-309048-emmtplv3 142 4 , , , cord-309048-emmtplv3 142 5 striking strike VBG cord-309048-emmtplv3 142 6 mesostructured mesostructured JJ cord-309048-emmtplv3 142 7 superassemblies superassemblie NNS cord-309048-emmtplv3 142 8 such such JJ cord-309048-emmtplv3 142 9 as as IN cord-309048-emmtplv3 142 10 composite composite JJ cord-309048-emmtplv3 142 11 threads thread NNS cord-309048-emmtplv3 142 12 , , , cord-309048-emmtplv3 142 13 nanoparticles nanoparticle NNS cord-309048-emmtplv3 142 14 with with IN cord-309048-emmtplv3 142 15 radial radial JJ cord-309048-emmtplv3 142 16 channels channel NNS cord-309048-emmtplv3 142 17 , , , cord-309048-emmtplv3 142 18 and and CC cord-309048-emmtplv3 142 19 hierarchically hierarchically RB cord-309048-emmtplv3 142 20 arranged arrange VBN cord-309048-emmtplv3 142 21 microtubes microtubes NNP cord-309048-emmtplv3 142 22 were be VBD cord-309048-emmtplv3 142 23 obtained obtain VBN cord-309048-emmtplv3 142 24 ( ( -LRB- cord-309048-emmtplv3 143 1 Fowler Fowler NNP cord-309048-emmtplv3 143 2 et et NNP cord-309048-emmtplv3 143 3 al al NNP cord-309048-emmtplv3 143 4 . . . cord-309048-emmtplv3 144 1 , , , cord-309048-emmtplv3 144 2 2001 2001 CD cord-309048-emmtplv3 144 3 ; ; : cord-309048-emmtplv3 144 4 Schenk Schenk NNP cord-309048-emmtplv3 144 5 et et NNP cord-309048-emmtplv3 144 6 al al NNP cord-309048-emmtplv3 144 7 . . NNP cord-309048-emmtplv3 144 8 , , , cord-309048-emmtplv3 144 9 2017 2017 CD cord-309048-emmtplv3 144 10 ) ) -RRB- cord-309048-emmtplv3 144 11 . . . cord-309048-emmtplv3 145 1 In in IN cord-309048-emmtplv3 145 2 fact fact NN cord-309048-emmtplv3 145 3 , , , cord-309048-emmtplv3 145 4 the the DT cord-309048-emmtplv3 145 5 use use NN cord-309048-emmtplv3 145 6 of of IN cord-309048-emmtplv3 145 7 plant plant NN cord-309048-emmtplv3 145 8 virus virus NN cord-309048-emmtplv3 145 9 particles particle NNS cord-309048-emmtplv3 145 10 , , , cord-309048-emmtplv3 145 11 including include VBG cord-309048-emmtplv3 145 12 TMV TMV NNP cord-309048-emmtplv3 145 13 Shenton Shenton NNP cord-309048-emmtplv3 145 14 et et NNP cord-309048-emmtplv3 145 15 al al NNP cord-309048-emmtplv3 145 16 . . NNP cord-309048-emmtplv3 145 17 , , , cord-309048-emmtplv3 145 18 1999 1999 CD cord-309048-emmtplv3 145 19 ) ) -RRB- cord-309048-emmtplv3 145 20 as as IN cord-309048-emmtplv3 145 21 mineralization mineralization NN cord-309048-emmtplv3 145 22 - - HYPH cord-309048-emmtplv3 145 23 guiding guide VBG cord-309048-emmtplv3 145 24 agents agent NNS cord-309048-emmtplv3 145 25 , , , cord-309048-emmtplv3 145 26 may may MD cord-309048-emmtplv3 145 27 be be VB cord-309048-emmtplv3 145 28 regarded regard VBN cord-309048-emmtplv3 145 29 the the DT cord-309048-emmtplv3 145 30 dawn dawn NN cord-309048-emmtplv3 145 31 of of IN cord-309048-emmtplv3 145 32 " " `` cord-309048-emmtplv3 145 33 structural structural JJ cord-309048-emmtplv3 145 34 TMV TMV NNP cord-309048-emmtplv3 145 35 nanotechnology nanotechnology NN cord-309048-emmtplv3 145 36 " " '' cord-309048-emmtplv3 145 37 ( ( -LRB- cord-309048-emmtplv3 145 38 Fig fig NN cord-309048-emmtplv3 145 39 . . NNP cord-309048-emmtplv3 145 40 2 2 CD cord-309048-emmtplv3 145 41 ) ) -RRB- cord-309048-emmtplv3 145 42 . . . cord-309048-emmtplv3 146 1 The the DT cord-309048-emmtplv3 146 2 deposition deposition NN cord-309048-emmtplv3 146 3 approach approach NN cord-309048-emmtplv3 146 4 has have VBZ cord-309048-emmtplv3 146 5 included include VBN cord-309048-emmtplv3 146 6 the the DT cord-309048-emmtplv3 146 7 creation creation NN cord-309048-emmtplv3 146 8 of of IN cord-309048-emmtplv3 146 9 metal metal NN cord-309048-emmtplv3 146 10 nanoparticles nanoparticle NNS cord-309048-emmtplv3 146 11 and and CC cord-309048-emmtplv3 146 12 nanotubes nanotube NNS cord-309048-emmtplv3 146 13 ( ( -LRB- cord-309048-emmtplv3 146 14 Dujardin Dujardin NNP cord-309048-emmtplv3 146 15 et et NNP cord-309048-emmtplv3 146 16 al al NNP cord-309048-emmtplv3 146 17 . . NNP cord-309048-emmtplv3 146 18 , , , cord-309048-emmtplv3 146 19 2003 2003 CD cord-309048-emmtplv3 146 20 ; ; : cord-309048-emmtplv3 146 21 Knez Knez NNP cord-309048-emmtplv3 146 22 et et FW cord-309048-emmtplv3 146 23 al al NNP cord-309048-emmtplv3 146 24 . . . cord-309048-emmtplv3 147 1 , , , cord-309048-emmtplv3 147 2 2002 2002 CD cord-309048-emmtplv3 148 1 Knez Knez NNP cord-309048-emmtplv3 148 2 et et FW cord-309048-emmtplv3 148 3 al al NNP cord-309048-emmtplv3 148 4 . . . cord-309048-emmtplv3 149 1 , , , cord-309048-emmtplv3 149 2 , , , cord-309048-emmtplv3 149 3 2003 2003 CD cord-309048-emmtplv3 150 1 Knez Knez NNP cord-309048-emmtplv3 150 2 et et FW cord-309048-emmtplv3 150 3 al al NNP cord-309048-emmtplv3 150 4 . . . cord-309048-emmtplv3 151 1 , , , cord-309048-emmtplv3 151 2 , , , cord-309048-emmtplv3 151 3 2004b 2004b CD cord-309048-emmtplv3 151 4 . . . cord-309048-emmtplv3 152 1 Such such JJ cord-309048-emmtplv3 152 2 tubes tube NNS cord-309048-emmtplv3 152 3 can can MD cord-309048-emmtplv3 152 4 be be VB cord-309048-emmtplv3 152 5 grown grow VBN cord-309048-emmtplv3 152 6 from from IN cord-309048-emmtplv3 152 7 deposited deposit VBN cord-309048-emmtplv3 152 8 clusters cluster NNS cord-309048-emmtplv3 152 9 of of IN cord-309048-emmtplv3 152 10 palladium palladium NN cord-309048-emmtplv3 152 11 , , , cord-309048-emmtplv3 152 12 platinum platinum NN cord-309048-emmtplv3 152 13 , , , cord-309048-emmtplv3 152 14 and and CC cord-309048-emmtplv3 152 15 gold gold NN cord-309048-emmtplv3 152 16 on on IN cord-309048-emmtplv3 152 17 the the DT cord-309048-emmtplv3 152 18 exterior exterior JJ cord-309048-emmtplv3 152 19 TMV TMV NNP cord-309048-emmtplv3 152 20 surface surface NN cord-309048-emmtplv3 152 21 and and CC cord-309048-emmtplv3 152 22 result result VB cord-309048-emmtplv3 152 23 in in IN cord-309048-emmtplv3 152 24 a a DT cord-309048-emmtplv3 152 25 metallic metallic JJ cord-309048-emmtplv3 152 26 coat coat NN cord-309048-emmtplv3 152 27 on on IN cord-309048-emmtplv3 152 28 the the DT cord-309048-emmtplv3 152 29 virion virion NN cord-309048-emmtplv3 152 30 that that WDT cord-309048-emmtplv3 152 31 serves serve VBZ cord-309048-emmtplv3 152 32 as as IN cord-309048-emmtplv3 152 33 a a DT cord-309048-emmtplv3 152 34 basal basal NN cord-309048-emmtplv3 152 35 layer layer NN cord-309048-emmtplv3 152 36 for for IN cord-309048-emmtplv3 152 37 electroless electroless NNP cord-309048-emmtplv3 152 38 plating plating NN cord-309048-emmtplv3 152 39 of of IN cord-309048-emmtplv3 152 40 other other JJ cord-309048-emmtplv3 152 41 metals metal NNS cord-309048-emmtplv3 152 42 including include VBG cord-309048-emmtplv3 152 43 nickel nickel NN cord-309048-emmtplv3 152 44 and and CC cord-309048-emmtplv3 152 45 cobalt cobalt NN cord-309048-emmtplv3 152 46 . . . cord-309048-emmtplv3 153 1 For for IN cord-309048-emmtplv3 153 2 example example NN cord-309048-emmtplv3 153 3 , , , cord-309048-emmtplv3 153 4 Royston Royston NNP cord-309048-emmtplv3 153 5 et et NNP cord-309048-emmtplv3 153 6 al al NNP cord-309048-emmtplv3 153 7 . . . cord-309048-emmtplv3 154 1 ( ( -LRB- cord-309048-emmtplv3 154 2 2008 2008 CD cord-309048-emmtplv3 154 3 ) ) -RRB- cord-309048-emmtplv3 154 4 reported report VBD cord-309048-emmtplv3 154 5 the the DT cord-309048-emmtplv3 154 6 deposition deposition NN cord-309048-emmtplv3 154 7 of of IN cord-309048-emmtplv3 154 8 nickel nickel NN cord-309048-emmtplv3 154 9 and and CC cord-309048-emmtplv3 154 10 cobalt cobalt NN cord-309048-emmtplv3 154 11 on on IN cord-309048-emmtplv3 154 12 the the DT cord-309048-emmtplv3 154 13 exterior exterior JJ cord-309048-emmtplv3 154 14 surface surface NN cord-309048-emmtplv3 154 15 of of IN cord-309048-emmtplv3 154 16 the the DT cord-309048-emmtplv3 154 17 virus virus NN cord-309048-emmtplv3 154 18 to to TO cord-309048-emmtplv3 154 19 create create VB cord-309048-emmtplv3 154 20 metallic metallic JJ cord-309048-emmtplv3 154 21 coatings coating NNS cord-309048-emmtplv3 154 22 up up IN cord-309048-emmtplv3 154 23 to to TO cord-309048-emmtplv3 154 24 40 40 CD cord-309048-emmtplv3 154 25 nm nm NN cord-309048-emmtplv3 154 26 in in IN cord-309048-emmtplv3 154 27 thickness thickness NN cord-309048-emmtplv3 154 28 . . . cord-309048-emmtplv3 155 1 When when WRB cord-309048-emmtplv3 155 2 the the DT cord-309048-emmtplv3 155 3 nickel nickel NN cord-309048-emmtplv3 155 4 - - HYPH cord-309048-emmtplv3 155 5 coated coat VBN cord-309048-emmtplv3 155 6 virions virion NNS cord-309048-emmtplv3 155 7 were be VBD cord-309048-emmtplv3 155 8 incorporated incorporate VBN cord-309048-emmtplv3 155 9 into into IN cord-309048-emmtplv3 155 10 a a DT cord-309048-emmtplv3 155 11 nickel nickel NN cord-309048-emmtplv3 155 12 - - HYPH cord-309048-emmtplv3 155 13 zinc zinc NN cord-309048-emmtplv3 155 14 battery battery NN cord-309048-emmtplv3 155 15 system system NN cord-309048-emmtplv3 155 16 , , , cord-309048-emmtplv3 155 17 the the DT cord-309048-emmtplv3 155 18 electrode electrode JJ cord-309048-emmtplv3 155 19 capacity capacity NN cord-309048-emmtplv3 155 20 of of IN cord-309048-emmtplv3 155 21 the the DT cord-309048-emmtplv3 155 22 battery battery NN cord-309048-emmtplv3 155 23 more more RBR cord-309048-emmtplv3 155 24 than than IN cord-309048-emmtplv3 155 25 doubled double VBD cord-309048-emmtplv3 155 26 due due IN cord-309048-emmtplv3 155 27 to to IN cord-309048-emmtplv3 155 28 the the DT cord-309048-emmtplv3 155 29 large large JJ cord-309048-emmtplv3 155 30 increase increase NN cord-309048-emmtplv3 155 31 of of IN cord-309048-emmtplv3 155 32 its -PRON- PRP$ cord-309048-emmtplv3 155 33 active active JJ cord-309048-emmtplv3 155 34 surface surface NN cord-309048-emmtplv3 155 35 area area NN cord-309048-emmtplv3 155 36 through through IN cord-309048-emmtplv3 155 37 the the DT cord-309048-emmtplv3 155 38 TMV TMV NNP cord-309048-emmtplv3 155 39 - - HYPH cord-309048-emmtplv3 155 40 derived derive VBN cord-309048-emmtplv3 155 41 nanostructures nanostructure NNS cord-309048-emmtplv3 155 42 . . . cord-309048-emmtplv3 156 1 Similarly similarly RB cord-309048-emmtplv3 156 2 , , , cord-309048-emmtplv3 156 3 TMV TMV NNP cord-309048-emmtplv3 156 4 nanorods nanorods NNP cord-309048-emmtplv3 156 5 immobilized immobilize VBN cord-309048-emmtplv3 156 6 on on IN cord-309048-emmtplv3 156 7 semiconducting semiconducte VBG cord-309048-emmtplv3 156 8 electrodes electrode NNS cord-309048-emmtplv3 156 9 and and CC cord-309048-emmtplv3 156 10 coated coat VBN cord-309048-emmtplv3 156 11 with with IN cord-309048-emmtplv3 156 12 nickel nickel NN cord-309048-emmtplv3 156 13 from from IN cord-309048-emmtplv3 156 14 solution solution NN cord-309048-emmtplv3 156 15 , , , cord-309048-emmtplv3 156 16 and and CC cord-309048-emmtplv3 156 17 subsequently subsequently RB cord-309048-emmtplv3 156 18 with with IN cord-309048-emmtplv3 156 19 indium indium JJ cord-309048-emmtplv3 156 20 - - HYPH cord-309048-emmtplv3 156 21 tin tin NN cord-309048-emmtplv3 156 22 oxide oxide NN cord-309048-emmtplv3 156 23 and and CC cord-309048-emmtplv3 156 24 copper copper NN cord-309048-emmtplv3 156 25 oxide oxide NN cord-309048-emmtplv3 156 26 layers layer NNS cord-309048-emmtplv3 156 27 by by IN cord-309048-emmtplv3 156 28 sputtering sputter VBG cord-309048-emmtplv3 156 29 and and CC cord-309048-emmtplv3 156 30 annealing annealing NN cord-309048-emmtplv3 156 31 , , , cord-309048-emmtplv3 156 32 yielded yield VBD cord-309048-emmtplv3 156 33 excellently excellently RB cord-309048-emmtplv3 156 34 performing perform VBG cord-309048-emmtplv3 156 35 photoelectrochemical photoelectrochemical JJ cord-309048-emmtplv3 156 36 cells cell NNS cord-309048-emmtplv3 156 37 . . . cord-309048-emmtplv3 157 1 The the DT cord-309048-emmtplv3 157 2 performance performance NN cord-309048-emmtplv3 157 3 of of IN cord-309048-emmtplv3 157 4 these these DT cord-309048-emmtplv3 157 5 structures structure NNS cord-309048-emmtplv3 157 6 also also RB cord-309048-emmtplv3 157 7 profited profit VBD cord-309048-emmtplv3 157 8 from from IN cord-309048-emmtplv3 157 9 the the DT cord-309048-emmtplv3 157 10 antireflective antireflective NNP cord-309048-emmtplv3 157 11 properties property NNS cord-309048-emmtplv3 157 12 of of IN cord-309048-emmtplv3 157 13 the the DT cord-309048-emmtplv3 157 14 3D 3d JJ cord-309048-emmtplv3 157 15 nanorod nanorod NNP cord-309048-emmtplv3 157 16 structures structure NNS cord-309048-emmtplv3 157 17 ( ( -LRB- cord-309048-emmtplv3 157 18 Chiang Chiang NNP cord-309048-emmtplv3 157 19 et et NNP cord-309048-emmtplv3 157 20 al al NNP cord-309048-emmtplv3 157 21 . . NNP cord-309048-emmtplv3 157 22 , , , cord-309048-emmtplv3 157 23 2012 2012 CD cord-309048-emmtplv3 157 24 ) ) -RRB- cord-309048-emmtplv3 157 25 . . . cord-309048-emmtplv3 158 1 Hydrogen hydrogen NN cord-309048-emmtplv3 158 2 generation generation NN cord-309048-emmtplv3 158 3 in in IN cord-309048-emmtplv3 158 4 these these DT cord-309048-emmtplv3 158 5 water water NN cord-309048-emmtplv3 158 6 - - HYPH cord-309048-emmtplv3 158 7 splitting split VBG cord-309048-emmtplv3 158 8 solar solar JJ cord-309048-emmtplv3 158 9 cells cell NNS cord-309048-emmtplv3 158 10 resulted result VBD cord-309048-emmtplv3 158 11 in in IN cord-309048-emmtplv3 158 12 higher high JJR cord-309048-emmtplv3 158 13 photocurrent photocurrent NN cord-309048-emmtplv3 158 14 densities density NNS cord-309048-emmtplv3 158 15 than than IN cord-309048-emmtplv3 158 16 reported report VBN cord-309048-emmtplv3 158 17 previously previously RB cord-309048-emmtplv3 158 18 for for IN cord-309048-emmtplv3 158 19 any any DT cord-309048-emmtplv3 158 20 other other JJ cord-309048-emmtplv3 158 21 system system NN cord-309048-emmtplv3 158 22 based base VBN cord-309048-emmtplv3 158 23 on on IN cord-309048-emmtplv3 158 24 similarly similarly RB cord-309048-emmtplv3 158 25 sized sized JJ cord-309048-emmtplv3 158 26 copper copper NN cord-309048-emmtplv3 158 27 oxide oxide NN cord-309048-emmtplv3 158 28 structures structure NNS cord-309048-emmtplv3 158 29 . . . cord-309048-emmtplv3 159 1 TMV TMV NNP cord-309048-emmtplv3 159 2 particles particle NNS cord-309048-emmtplv3 159 3 are be VBP cord-309048-emmtplv3 159 4 hollow hollow JJ cord-309048-emmtplv3 159 5 cylinders cylinder NNS cord-309048-emmtplv3 159 6 with with IN cord-309048-emmtplv3 159 7 an an DT cord-309048-emmtplv3 159 8 internal internal JJ cord-309048-emmtplv3 159 9 diameter diameter NN cord-309048-emmtplv3 159 10 of of IN cord-309048-emmtplv3 159 11 4 4 CD cord-309048-emmtplv3 159 12 nm nm NN cord-309048-emmtplv3 160 1 ( ( -LRB- cord-309048-emmtplv3 160 2 Fig Fig NNP cord-309048-emmtplv3 160 3 . . . cord-309048-emmtplv3 160 4 1E 1E NNP cord-309048-emmtplv3 160 5 ) ) -RRB- cord-309048-emmtplv3 160 6 . . . cord-309048-emmtplv3 161 1 The the DT cord-309048-emmtplv3 161 2 interior interior JJ cord-309048-emmtplv3 161 3 channel channel NN cord-309048-emmtplv3 161 4 is be VBZ cord-309048-emmtplv3 161 5 lined line VBN cord-309048-emmtplv3 161 6 with with IN cord-309048-emmtplv3 161 7 aspartic aspartic JJ cord-309048-emmtplv3 161 8 and and CC cord-309048-emmtplv3 161 9 glutamic glutamic NN cord-309048-emmtplv3 161 10 acid acid NN cord-309048-emmtplv3 161 11 residues residue NNS cord-309048-emmtplv3 161 12 and and CC cord-309048-emmtplv3 161 13 these these DT cord-309048-emmtplv3 161 14 have have VBP cord-309048-emmtplv3 161 15 been be VBN cord-309048-emmtplv3 161 16 labeled label VBN cord-309048-emmtplv3 161 17 with with IN cord-309048-emmtplv3 161 18 a a DT cord-309048-emmtplv3 161 19 variety variety NN cord-309048-emmtplv3 161 20 of of IN cord-309048-emmtplv3 161 21 small small JJ cord-309048-emmtplv3 161 22 molecules molecule NNS cord-309048-emmtplv3 161 23 , , , cord-309048-emmtplv3 161 24 such such JJ cord-309048-emmtplv3 161 25 as as IN cord-309048-emmtplv3 161 26 biotin biotin NN cord-309048-emmtplv3 161 27 , , , cord-309048-emmtplv3 161 28 using use VBG cord-309048-emmtplv3 161 29 carbodiimide carbodiimide NN cord-309048-emmtplv3 161 30 coupling coupling NN cord-309048-emmtplv3 161 31 reactions reaction NNS cord-309048-emmtplv3 161 32 ( ( -LRB- cord-309048-emmtplv3 161 33 Schlick Schlick NNP cord-309048-emmtplv3 161 34 et et FW cord-309048-emmtplv3 161 35 al al NNP cord-309048-emmtplv3 161 36 . . NNP cord-309048-emmtplv3 161 37 , , , cord-309048-emmtplv3 161 38 2005 2005 CD cord-309048-emmtplv3 161 39 ) ) -RRB- cord-309048-emmtplv3 161 40 . . . cord-309048-emmtplv3 162 1 Nanowires Nanowires NNP cord-309048-emmtplv3 162 2 consisting consist VBG cord-309048-emmtplv3 162 3 of of IN cord-309048-emmtplv3 162 4 bimetallic bimetallic JJ cord-309048-emmtplv3 162 5 alloys alloy NNS cord-309048-emmtplv3 162 6 of of IN cord-309048-emmtplv3 162 7 CoPt CoPt NNP cord-309048-emmtplv3 162 8 , , , cord-309048-emmtplv3 162 9 CoPt CoPt NNP cord-309048-emmtplv3 162 10 3 3 CD cord-309048-emmtplv3 162 11 , , , cord-309048-emmtplv3 162 12 and and CC cord-309048-emmtplv3 162 13 FePt FePt NNP cord-309048-emmtplv3 162 14 3 3 CD cord-309048-emmtplv3 162 15 with with IN cord-309048-emmtplv3 162 16 lengths length NNS cord-309048-emmtplv3 162 17 up up IN cord-309048-emmtplv3 162 18 to to TO cord-309048-emmtplv3 162 19 100 100 CD cord-309048-emmtplv3 162 20 and and CC cord-309048-emmtplv3 162 21 4 4 CD cord-309048-emmtplv3 162 22 nm nm NN cord-309048-emmtplv3 162 23 diameter diameter NN cord-309048-emmtplv3 162 24 have have VBP cord-309048-emmtplv3 162 25 been be VBN cord-309048-emmtplv3 162 26 synthesized synthesize VBN cord-309048-emmtplv3 162 27 within within IN cord-309048-emmtplv3 162 28 the the DT cord-309048-emmtplv3 162 29 TMV TMV NNP cord-309048-emmtplv3 162 30 capsid capsid NN cord-309048-emmtplv3 162 31 channel channel NN cord-309048-emmtplv3 162 32 ( ( -LRB- cord-309048-emmtplv3 162 33 Tsukamoto Tsukamoto NNP cord-309048-emmtplv3 162 34 et et FW cord-309048-emmtplv3 162 35 al al NNP cord-309048-emmtplv3 162 36 . . NNP cord-309048-emmtplv3 162 37 , , , cord-309048-emmtplv3 162 38 2007 2007 CD cord-309048-emmtplv3 162 39 ) ) -RRB- cord-309048-emmtplv3 162 40 , , , cord-309048-emmtplv3 162 41 and and CC cord-309048-emmtplv3 162 42 the the DT cord-309048-emmtplv3 162 43 formation formation NN cord-309048-emmtplv3 162 44 of of IN cord-309048-emmtplv3 162 45 small small JJ cord-309048-emmtplv3 162 46 isolated isolate VBN cord-309048-emmtplv3 162 47 nanoparticles nanoparticle NNS cord-309048-emmtplv3 162 48 of of IN cord-309048-emmtplv3 162 49 silver silver NN cord-309048-emmtplv3 162 50 and and CC cord-309048-emmtplv3 162 51 nickel nickel NN cord-309048-emmtplv3 162 52 within within IN cord-309048-emmtplv3 162 53 the the DT cord-309048-emmtplv3 162 54 channel channel NN cord-309048-emmtplv3 162 55 has have VBZ cord-309048-emmtplv3 162 56 also also RB cord-309048-emmtplv3 162 57 been be VBN cord-309048-emmtplv3 162 58 reported report VBN cord-309048-emmtplv3 163 1 ( ( -LRB- cord-309048-emmtplv3 163 2 Dujardin Dujardin NNP cord-309048-emmtplv3 163 3 et et NNP cord-309048-emmtplv3 163 4 al al NNP cord-309048-emmtplv3 163 5 . . NNP cord-309048-emmtplv3 163 6 , , , cord-309048-emmtplv3 163 7 2003 2003 CD cord-309048-emmtplv3 163 8 ) ) -RRB- cord-309048-emmtplv3 163 9 . . . cord-309048-emmtplv3 164 1 Taken take VBN cord-309048-emmtplv3 164 2 together together RB cord-309048-emmtplv3 164 3 , , , cord-309048-emmtplv3 164 4 these these DT cord-309048-emmtplv3 164 5 examples example NNS cord-309048-emmtplv3 164 6 demonstrate demonstrate VBP cord-309048-emmtplv3 164 7 effective effective JJ cord-309048-emmtplv3 164 8 templating templating NN cord-309048-emmtplv3 164 9 of of IN cord-309048-emmtplv3 164 10 inorganic inorganic JJ cord-309048-emmtplv3 164 11 solid solid JJ cord-309048-emmtplv3 164 12 and and CC cord-309048-emmtplv3 164 13 tubular tubular JJ cord-309048-emmtplv3 164 14 structures structure NNS cord-309048-emmtplv3 164 15 by by IN cord-309048-emmtplv3 164 16 TMV TMV NNP cord-309048-emmtplv3 164 17 , , , cord-309048-emmtplv3 164 18 and and CC cord-309048-emmtplv3 164 19 the the DT cord-309048-emmtplv3 164 20 process process NN cord-309048-emmtplv3 164 21 has have VBZ cord-309048-emmtplv3 164 22 now now RB cord-309048-emmtplv3 164 23 reached reach VBN cord-309048-emmtplv3 164 24 the the DT cord-309048-emmtplv3 164 25 state state NN cord-309048-emmtplv3 164 26 of of IN cord-309048-emmtplv3 164 27 being be VBG cord-309048-emmtplv3 164 28 competitive competitive JJ cord-309048-emmtplv3 164 29 with with IN cord-309048-emmtplv3 164 30 conventional conventional JJ cord-309048-emmtplv3 164 31 production production NN cord-309048-emmtplv3 164 32 processes process NNS cord-309048-emmtplv3 164 33 for for IN cord-309048-emmtplv3 164 34 several several JJ cord-309048-emmtplv3 164 35 applications application NNS cord-309048-emmtplv3 164 36 ( ( -LRB- cord-309048-emmtplv3 164 37 Fig Fig NNP cord-309048-emmtplv3 164 38 . . NNP cord-309048-emmtplv3 164 39 2 2 CD cord-309048-emmtplv3 164 40 ) ) -RRB- cord-309048-emmtplv3 164 41 . . . cord-309048-emmtplv3 165 1 These these DT cord-309048-emmtplv3 165 2 range range VBP cord-309048-emmtplv3 165 3 from from IN cord-309048-emmtplv3 165 4 conductive conductive JJ cord-309048-emmtplv3 165 5 to to IN cord-309048-emmtplv3 165 6 electronically electronically RB cord-309048-emmtplv3 165 7 , , , cord-309048-emmtplv3 165 8 plasmonically plasmonically RB cord-309048-emmtplv3 165 9 , , , cord-309048-emmtplv3 165 10 and and CC cord-309048-emmtplv3 165 11 catalytically catalytically RB cord-309048-emmtplv3 165 12 ( ( -LRB- cord-309048-emmtplv3 165 13 Manocchi Manocchi NNP cord-309048-emmtplv3 165 14 et et NNP cord-309048-emmtplv3 165 15 al al NNP cord-309048-emmtplv3 165 16 . . NNP cord-309048-emmtplv3 165 17 , , , cord-309048-emmtplv3 165 18 2010 2010 CD cord-309048-emmtplv3 165 19 ) ) -RRB- cord-309048-emmtplv3 165 20 active active JJ cord-309048-emmtplv3 165 21 parts part NNS cord-309048-emmtplv3 165 22 ( ( -LRB- cord-309048-emmtplv3 165 23 for for IN cord-309048-emmtplv3 165 24 reviews review NNS cord-309048-emmtplv3 165 25 , , , cord-309048-emmtplv3 165 26 see see VB cord-309048-emmtplv3 165 27 Culver Culver NNP cord-309048-emmtplv3 165 28 et et NNP cord-309048-emmtplv3 165 29 al al NNP cord-309048-emmtplv3 165 30 . . . cord-309048-emmtplv3 166 1 , , , cord-309048-emmtplv3 166 2 2015 2015 CD cord-309048-emmtplv3 166 3 ; ; : cord-309048-emmtplv3 166 4 Fan Fan NNP cord-309048-emmtplv3 166 5 et et NNP cord-309048-emmtplv3 166 6 al al NNP cord-309048-emmtplv3 166 7 . . NNP cord-309048-emmtplv3 166 8 , , , cord-309048-emmtplv3 166 9 2013 2013 CD cord-309048-emmtplv3 166 10 ) ) -RRB- cord-309048-emmtplv3 166 11 . . . cord-309048-emmtplv3 167 1 Because because IN cord-309048-emmtplv3 167 2 of of IN cord-309048-emmtplv3 167 3 their -PRON- PRP$ cord-309048-emmtplv3 167 4 size size NN cord-309048-emmtplv3 167 5 and and CC cord-309048-emmtplv3 167 6 biocompatibility biocompatibility NN cord-309048-emmtplv3 167 7 , , , cord-309048-emmtplv3 167 8 for for IN cord-309048-emmtplv3 167 9 the the DT cord-309048-emmtplv3 167 10 past past JJ cord-309048-emmtplv3 167 11 decade decade NN cord-309048-emmtplv3 167 12 or or CC cord-309048-emmtplv3 167 13 so so RB cord-309048-emmtplv3 167 14 plant plant NN cord-309048-emmtplv3 167 15 virus virus NN cord-309048-emmtplv3 167 16 particles particle NNS cord-309048-emmtplv3 167 17 have have VBP cord-309048-emmtplv3 167 18 been be VBN cord-309048-emmtplv3 167 19 considered consider VBN cord-309048-emmtplv3 167 20 as as IN cord-309048-emmtplv3 167 21 promising promising JJ cord-309048-emmtplv3 167 22 drug drug NN cord-309048-emmtplv3 167 23 delivery delivery NN cord-309048-emmtplv3 167 24 vehicles vehicle NNS cord-309048-emmtplv3 167 25 , , , cord-309048-emmtplv3 167 26 particularly particularly RB cord-309048-emmtplv3 167 27 in in IN cord-309048-emmtplv3 167 28 relation relation NN cord-309048-emmtplv3 167 29 to to IN cord-309048-emmtplv3 167 30 anticancer anticancer JJ cord-309048-emmtplv3 167 31 drugs drug NNS cord-309048-emmtplv3 167 32 ( ( -LRB- cord-309048-emmtplv3 167 33 Franzen Franzen NNP cord-309048-emmtplv3 167 34 and and CC cord-309048-emmtplv3 167 35 Lommel Lommel NNP cord-309048-emmtplv3 167 36 , , , cord-309048-emmtplv3 167 37 2009 2009 CD cord-309048-emmtplv3 167 38 ) ) -RRB- cord-309048-emmtplv3 167 39 . . . cord-309048-emmtplv3 168 1 Much much JJ cord-309048-emmtplv3 168 2 of of IN cord-309048-emmtplv3 168 3 the the DT cord-309048-emmtplv3 168 4 research research NN cord-309048-emmtplv3 168 5 in in IN cord-309048-emmtplv3 168 6 this this DT cord-309048-emmtplv3 168 7 area area NN cord-309048-emmtplv3 168 8 has have VBZ cord-309048-emmtplv3 168 9 focussed focusse VBN cord-309048-emmtplv3 168 10 on on IN cord-309048-emmtplv3 168 11 spherical spherical JJ cord-309048-emmtplv3 168 12 viruses virus NNS cord-309048-emmtplv3 168 13 since since IN cord-309048-emmtplv3 168 14 the the DT cord-309048-emmtplv3 168 15 capsid capsid NN cord-309048-emmtplv3 168 16 subunits subunit NNS cord-309048-emmtplv3 168 17 form form NN cord-309048-emmtplv3 168 18 closed close VBN cord-309048-emmtplv3 168 19 shells shell NNS cord-309048-emmtplv3 168 20 Wen Wen NNP cord-309048-emmtplv3 168 21 and and CC cord-309048-emmtplv3 168 22 Steinmetz Steinmetz NNP cord-309048-emmtplv3 168 23 , , , cord-309048-emmtplv3 168 24 2016 2016 CD cord-309048-emmtplv3 168 25 ) ) -RRB- cord-309048-emmtplv3 168 26 ; ; : cord-309048-emmtplv3 168 27 by by IN cord-309048-emmtplv3 168 28 contrast contrast NN cord-309048-emmtplv3 168 29 , , , cord-309048-emmtplv3 168 30 the the DT cord-309048-emmtplv3 168 31 open open RB cord-309048-emmtplv3 168 32 - - HYPH cord-309048-emmtplv3 168 33 ended ended JJ cord-309048-emmtplv3 168 34 tubular tubular JJ cord-309048-emmtplv3 168 35 particles particle NNS cord-309048-emmtplv3 168 36 are be VBP cord-309048-emmtplv3 168 37 less less RBR cord-309048-emmtplv3 168 38 obvious obvious JJ cord-309048-emmtplv3 168 39 candidates candidate NNS cord-309048-emmtplv3 168 40 . . . cord-309048-emmtplv3 169 1 However however RB cord-309048-emmtplv3 169 2 , , , cord-309048-emmtplv3 169 3 Czapar Czapar NNP cord-309048-emmtplv3 169 4 et et NNP cord-309048-emmtplv3 169 5 al al NNP cord-309048-emmtplv3 169 6 . . . cord-309048-emmtplv3 170 1 ( ( -LRB- cord-309048-emmtplv3 170 2 2016 2016 CD cord-309048-emmtplv3 170 3 ) ) -RRB- cord-309048-emmtplv3 170 4 made make VBD cord-309048-emmtplv3 170 5 use use NN cord-309048-emmtplv3 170 6 of of IN cord-309048-emmtplv3 170 7 the the DT cord-309048-emmtplv3 170 8 density density NN cord-309048-emmtplv3 170 9 of of IN cord-309048-emmtplv3 170 10 negative negative JJ cord-309048-emmtplv3 170 11 charges charge NNS cord-309048-emmtplv3 170 12 lining line VBG cord-309048-emmtplv3 170 13 the the DT cord-309048-emmtplv3 170 14 inner inner JJ cord-309048-emmtplv3 170 15 channel channel NN cord-309048-emmtplv3 170 16 to to TO cord-309048-emmtplv3 170 17 load load VB cord-309048-emmtplv3 170 18 TMV TMV NNP cord-309048-emmtplv3 170 19 particles particle NNS cord-309048-emmtplv3 170 20 with with IN cord-309048-emmtplv3 170 21 a a DT cord-309048-emmtplv3 170 22 potent potent JJ cord-309048-emmtplv3 170 23 platinum platinum NN cord-309048-emmtplv3 170 24 - - HYPH cord-309048-emmtplv3 170 25 based base VBN cord-309048-emmtplv3 170 26 anticancer anticancer JJ cord-309048-emmtplv3 170 27 agent agent NN cord-309048-emmtplv3 170 28 , , , cord-309048-emmtplv3 170 29 phenanthriplatin phenanthriplatin NNP cord-309048-emmtplv3 170 30 ( ( -LRB- cord-309048-emmtplv3 170 31 PhenPt PhenPt NNP cord-309048-emmtplv3 170 32 ) ) -RRB- cord-309048-emmtplv3 170 33 . . . cord-309048-emmtplv3 171 1 When when WRB cord-309048-emmtplv3 171 2 TMV TMV NNP cord-309048-emmtplv3 171 3 rods rod NNS cord-309048-emmtplv3 171 4 were be VBD cord-309048-emmtplv3 171 5 incubated incubate VBN cord-309048-emmtplv3 171 6 with with IN cord-309048-emmtplv3 171 7 a a DT cord-309048-emmtplv3 171 8 cationic cationic JJ cord-309048-emmtplv3 171 9 form form NN cord-309048-emmtplv3 171 10 of of IN cord-309048-emmtplv3 171 11 the the DT cord-309048-emmtplv3 171 12 drug drug NN cord-309048-emmtplv3 171 13 , , , cord-309048-emmtplv3 171 14 approximately approximately RB cord-309048-emmtplv3 171 15 2000 2000 CD cord-309048-emmtplv3 171 16 PhenPt phenpt CD cord-309048-emmtplv3 171 17 2 2 CD cord-309048-emmtplv3 171 18 + + SYM cord-309048-emmtplv3 171 19 cations cation NNS cord-309048-emmtplv3 171 20 were be VBD cord-309048-emmtplv3 171 21 incorporated incorporate VBN cord-309048-emmtplv3 171 22 , , , cord-309048-emmtplv3 171 23 consistent consistent JJ cord-309048-emmtplv3 171 24 with with IN cord-309048-emmtplv3 171 25 the the DT cord-309048-emmtplv3 171 26 idea idea NN cord-309048-emmtplv3 171 27 that that IN cord-309048-emmtplv3 171 28 binding binding NN cord-309048-emmtplv3 171 29 occurs occur VBZ cord-309048-emmtplv3 171 30 through through IN cord-309048-emmtplv3 171 31 ionic ionic JJ cord-309048-emmtplv3 171 32 interaction interaction NN cord-309048-emmtplv3 171 33 with with IN cord-309048-emmtplv3 171 34 the the DT cord-309048-emmtplv3 171 35 carboxylate carboxylate NNP cord-309048-emmtplv3 171 36 groups group NNS cord-309048-emmtplv3 171 37 lining line VBG cord-309048-emmtplv3 171 38 the the DT cord-309048-emmtplv3 171 39 inner inner JJ cord-309048-emmtplv3 171 40 channel channel NN cord-309048-emmtplv3 171 41 of of IN cord-309048-emmtplv3 171 42 the the DT cord-309048-emmtplv3 171 43 virus virus NN cord-309048-emmtplv3 171 44 particles particle NNS cord-309048-emmtplv3 171 45 . . . cord-309048-emmtplv3 172 1 The the DT cord-309048-emmtplv3 172 2 drug drug NN cord-309048-emmtplv3 172 3 could could MD cord-309048-emmtplv3 172 4 be be VB cord-309048-emmtplv3 172 5 released release VBN cord-309048-emmtplv3 172 6 by by IN cord-309048-emmtplv3 172 7 lowering lower VBG cord-309048-emmtplv3 172 8 the the DT cord-309048-emmtplv3 172 9 pH ph NN cord-309048-emmtplv3 172 10 of of IN cord-309048-emmtplv3 172 11 the the DT cord-309048-emmtplv3 172 12 medium medium NN cord-309048-emmtplv3 172 13 . . . cord-309048-emmtplv3 173 1 Subsequent subsequent JJ cord-309048-emmtplv3 173 2 work work NN cord-309048-emmtplv3 173 3 using use VBG cord-309048-emmtplv3 173 4 TMV TMV NNP cord-309048-emmtplv3 173 5 particles particle NNS cord-309048-emmtplv3 173 6 loaded load VBN cord-309048-emmtplv3 173 7 with with IN cord-309048-emmtplv3 173 8 a a DT cord-309048-emmtplv3 173 9 related related JJ cord-309048-emmtplv3 173 10 drug drug NN cord-309048-emmtplv3 173 11 , , , cord-309048-emmtplv3 173 12 cisplatin cisplatin NN cord-309048-emmtplv3 173 13 , , , cord-309048-emmtplv3 173 14 showed show VBD cord-309048-emmtplv3 173 15 that that IN cord-309048-emmtplv3 173 16 TMV TMV NNP cord-309048-emmtplv3 173 17 particles particle NNS cord-309048-emmtplv3 173 18 are be VBP cord-309048-emmtplv3 173 19 an an DT cord-309048-emmtplv3 173 20 efficient efficient JJ cord-309048-emmtplv3 173 21 way way NN cord-309048-emmtplv3 173 22 of of IN cord-309048-emmtplv3 173 23 delivering deliver VBG cord-309048-emmtplv3 173 24 anticancer anticancer JJ cord-309048-emmtplv3 173 25 therapeutics therapeutic NNS cord-309048-emmtplv3 173 26 ( ( -LRB- cord-309048-emmtplv3 173 27 Franke Franke NNP cord-309048-emmtplv3 173 28 et et NNP cord-309048-emmtplv3 173 29 al al NNP cord-309048-emmtplv3 173 30 . . NNP cord-309048-emmtplv3 173 31 , , , cord-309048-emmtplv3 173 32 2017 2017 CD cord-309048-emmtplv3 173 33 ) ) -RRB- cord-309048-emmtplv3 173 34 . . . cord-309048-emmtplv3 174 1 Although although IN cord-309048-emmtplv3 174 2 infection infection NN cord-309048-emmtplv3 174 3 of of IN cord-309048-emmtplv3 174 4 plants plant NNS cord-309048-emmtplv3 174 5 can can MD cord-309048-emmtplv3 174 6 lead lead VB cord-309048-emmtplv3 174 7 to to IN cord-309048-emmtplv3 174 8 the the DT cord-309048-emmtplv3 174 9 production production NN cord-309048-emmtplv3 174 10 of of IN cord-309048-emmtplv3 174 11 very very RB cord-309048-emmtplv3 174 12 high high JJ cord-309048-emmtplv3 174 13 levels level NNS cord-309048-emmtplv3 174 14 of of IN cord-309048-emmtplv3 174 15 assembled assemble VBN cord-309048-emmtplv3 174 16 particles particle NNS cord-309048-emmtplv3 174 17 , , , cord-309048-emmtplv3 174 18 this this DT cord-309048-emmtplv3 174 19 approach approach NN cord-309048-emmtplv3 174 20 has have VBZ cord-309048-emmtplv3 174 21 some some DT cord-309048-emmtplv3 174 22 limitations limitation NNS cord-309048-emmtplv3 174 23 . . . cord-309048-emmtplv3 175 1 For for IN cord-309048-emmtplv3 175 2 example example NN cord-309048-emmtplv3 175 3 , , , cord-309048-emmtplv3 175 4 the the DT cord-309048-emmtplv3 175 5 length length NN cord-309048-emmtplv3 175 6 of of IN cord-309048-emmtplv3 175 7 the the DT cord-309048-emmtplv3 175 8 genomic genomic JJ cord-309048-emmtplv3 175 9 RNA RNA NNP cord-309048-emmtplv3 175 10 inevitably inevitably RB cord-309048-emmtplv3 175 11 governs govern VBZ cord-309048-emmtplv3 175 12 the the DT cord-309048-emmtplv3 175 13 length length NN cord-309048-emmtplv3 175 14 of of IN cord-309048-emmtplv3 175 15 the the DT cord-309048-emmtplv3 175 16 particles particle NNS cord-309048-emmtplv3 175 17 . . . cord-309048-emmtplv3 176 1 Although although IN cord-309048-emmtplv3 176 2 the the DT cord-309048-emmtplv3 176 3 genomic genomic JJ cord-309048-emmtplv3 176 4 RNA RNA NNP cord-309048-emmtplv3 176 5 can can MD cord-309048-emmtplv3 176 6 be be VB cord-309048-emmtplv3 176 7 modified modify VBN cord-309048-emmtplv3 176 8 to to IN cord-309048-emmtplv3 176 9 a a DT cord-309048-emmtplv3 176 10 certain certain JJ cord-309048-emmtplv3 176 11 extent extent NN cord-309048-emmtplv3 176 12 by by IN cord-309048-emmtplv3 176 13 inserting insert VBG cord-309048-emmtplv3 176 14 or or CC cord-309048-emmtplv3 176 15 deleting delete VBG cord-309048-emmtplv3 176 16 viral viral JJ cord-309048-emmtplv3 176 17 sequences sequence NNS cord-309048-emmtplv3 176 18 , , , cord-309048-emmtplv3 176 19 the the DT cord-309048-emmtplv3 176 20 range range NN cord-309048-emmtplv3 176 21 of of IN cord-309048-emmtplv3 176 22 variation variation NN cord-309048-emmtplv3 176 23 is be VBZ cord-309048-emmtplv3 176 24 quite quite RB cord-309048-emmtplv3 176 25 limited limit VBN cord-309048-emmtplv3 176 26 if if IN cord-309048-emmtplv3 176 27 infectivity infectivity NN cord-309048-emmtplv3 176 28 is be VBZ cord-309048-emmtplv3 176 29 to to TO cord-309048-emmtplv3 176 30 be be VB cord-309048-emmtplv3 176 31 retained retain VBN cord-309048-emmtplv3 176 32 . . . cord-309048-emmtplv3 177 1 Additional additional JJ cord-309048-emmtplv3 177 2 issues issue NNS cord-309048-emmtplv3 177 3 include include VBP cord-309048-emmtplv3 177 4 the the DT cord-309048-emmtplv3 177 5 very very RB cord-309048-emmtplv3 177 6 infectious infectious JJ cord-309048-emmtplv3 177 7 nature nature NN cord-309048-emmtplv3 177 8 of of IN cord-309048-emmtplv3 177 9 the the DT cord-309048-emmtplv3 177 10 particles particle NNS cord-309048-emmtplv3 177 11 meaning mean VBG cord-309048-emmtplv3 177 12 that that IN cord-309048-emmtplv3 177 13 some some DT cord-309048-emmtplv3 177 14 degree degree NN cord-309048-emmtplv3 177 15 of of IN cord-309048-emmtplv3 177 16 containment containment NN cord-309048-emmtplv3 177 17 is be VBZ cord-309048-emmtplv3 177 18 required require VBN cord-309048-emmtplv3 177 19 during during IN cord-309048-emmtplv3 177 20 their -PRON- PRP$ cord-309048-emmtplv3 177 21 production production NN cord-309048-emmtplv3 177 22 and and CC cord-309048-emmtplv3 177 23 the the DT cord-309048-emmtplv3 177 24 fact fact NN cord-309048-emmtplv3 177 25 modifications modification NNS cord-309048-emmtplv3 177 26 to to IN cord-309048-emmtplv3 177 27 the the DT cord-309048-emmtplv3 177 28 CP cp NN cord-309048-emmtplv3 177 29 can can MD cord-309048-emmtplv3 177 30 make make VB cord-309048-emmtplv3 177 31 virions virion NNS cord-309048-emmtplv3 177 32 difficult difficult JJ cord-309048-emmtplv3 177 33 to to TO cord-309048-emmtplv3 177 34 purify purify VB cord-309048-emmtplv3 177 35 . . . cord-309048-emmtplv3 178 1 For for IN cord-309048-emmtplv3 178 2 these these DT cord-309048-emmtplv3 178 3 reasons reason NNS cord-309048-emmtplv3 178 4 , , , cord-309048-emmtplv3 178 5 there there EX cord-309048-emmtplv3 178 6 have have VBP cord-309048-emmtplv3 178 7 been be VBN cord-309048-emmtplv3 178 8 many many JJ cord-309048-emmtplv3 178 9 attempts attempt NNS cord-309048-emmtplv3 178 10 to to TO cord-309048-emmtplv3 178 11 produce produce VB cord-309048-emmtplv3 178 12 virus virus NN cord-309048-emmtplv3 178 13 particles particle NNS cord-309048-emmtplv3 178 14 in in IN cord-309048-emmtplv3 178 15 a a DT cord-309048-emmtplv3 178 16 variety variety NN cord-309048-emmtplv3 178 17 of of IN cord-309048-emmtplv3 178 18 expression expression NN cord-309048-emmtplv3 178 19 systems system NNS cord-309048-emmtplv3 178 20 in in IN cord-309048-emmtplv3 178 21 the the DT cord-309048-emmtplv3 178 22 absence absence NN cord-309048-emmtplv3 178 23 of of IN cord-309048-emmtplv3 178 24 infection infection NN cord-309048-emmtplv3 178 25 . . . cord-309048-emmtplv3 179 1 An an DT cord-309048-emmtplv3 179 2 early early JJ cord-309048-emmtplv3 179 3 attempt attempt NN cord-309048-emmtplv3 179 4 to to TO cord-309048-emmtplv3 179 5 exploit exploit VB cord-309048-emmtplv3 179 6 TMV TMV NNP cord-309048-emmtplv3 179 7 particles particle NNS cord-309048-emmtplv3 179 8 as as IN cord-309048-emmtplv3 179 9 a a DT cord-309048-emmtplv3 179 10 platform platform NN cord-309048-emmtplv3 179 11 for for IN cord-309048-emmtplv3 179 12 the the DT cord-309048-emmtplv3 179 13 display display NN cord-309048-emmtplv3 179 14 of of IN cord-309048-emmtplv3 179 15 foreign foreign JJ cord-309048-emmtplv3 179 16 peptides peptide NNS cord-309048-emmtplv3 179 17 involved involve VBN cord-309048-emmtplv3 179 18 expressing express VBG cord-309048-emmtplv3 179 19 a a DT cord-309048-emmtplv3 179 20 version version NN cord-309048-emmtplv3 179 21 of of IN cord-309048-emmtplv3 179 22 the the DT cord-309048-emmtplv3 179 23 CP cp NN cord-309048-emmtplv3 179 24 , , , cord-309048-emmtplv3 179 25 modified modify VBN cord-309048-emmtplv3 179 26 to to TO cord-309048-emmtplv3 179 27 carry carry VB cord-309048-emmtplv3 179 28 an an DT cord-309048-emmtplv3 179 29 eight eight CD cord-309048-emmtplv3 179 30 - - HYPH cord-309048-emmtplv3 179 31 amino amino NN cord-309048-emmtplv3 179 32 acid acid NN cord-309048-emmtplv3 179 33 poliovirus poliovirus NN cord-309048-emmtplv3 179 34 epitope epitope NN cord-309048-emmtplv3 179 35 at at IN cord-309048-emmtplv3 179 36 its -PRON- PRP$ cord-309048-emmtplv3 179 37 C c NN cord-309048-emmtplv3 179 38 - - HYPH cord-309048-emmtplv3 179 39 terminus terminus NN cord-309048-emmtplv3 179 40 , , , cord-309048-emmtplv3 179 41 in in IN cord-309048-emmtplv3 179 42 E. E. NNP cord-309048-emmtplv3 179 43 coli coli NNS cord-309048-emmtplv3 179 44 ( ( -LRB- cord-309048-emmtplv3 179 45 Haynes Haynes NNP cord-309048-emmtplv3 179 46 et et NNP cord-309048-emmtplv3 179 47 al al NNP cord-309048-emmtplv3 179 48 . . NNP cord-309048-emmtplv3 179 49 , , , cord-309048-emmtplv3 179 50 1986 1986 CD cord-309048-emmtplv3 179 51 ) ) -RRB- cord-309048-emmtplv3 179 52 . . . cord-309048-emmtplv3 180 1 Particles particle NNS cord-309048-emmtplv3 180 2 were be VBD cord-309048-emmtplv3 180 3 formed form VBN cord-309048-emmtplv3 180 4 and and CC cord-309048-emmtplv3 180 5 purified purify VBN cord-309048-emmtplv3 180 6 after after IN cord-309048-emmtplv3 180 7 acidification acidification NN cord-309048-emmtplv3 180 8 of of IN cord-309048-emmtplv3 180 9 bacterial bacterial JJ cord-309048-emmtplv3 180 10 extracts extract NNS cord-309048-emmtplv3 180 11 expressing express VBG cord-309048-emmtplv3 180 12 soluble soluble JJ cord-309048-emmtplv3 180 13 CP cp NN cord-309048-emmtplv3 180 14 . . . cord-309048-emmtplv3 181 1 The the DT cord-309048-emmtplv3 181 2 polymerized polymerize VBN cord-309048-emmtplv3 181 3 protein protein NN cord-309048-emmtplv3 181 4 - - HYPH cord-309048-emmtplv3 181 5 only only JJ cord-309048-emmtplv3 181 6 rods rod NNS cord-309048-emmtplv3 181 7 were be VBD cord-309048-emmtplv3 181 8 able able JJ cord-309048-emmtplv3 181 9 to to TO cord-309048-emmtplv3 181 10 elicit elicit VB cord-309048-emmtplv3 181 11 the the DT cord-309048-emmtplv3 181 12 production production NN cord-309048-emmtplv3 181 13 of of IN cord-309048-emmtplv3 181 14 higher high JJR cord-309048-emmtplv3 181 15 titers titer NNS cord-309048-emmtplv3 181 16 of of IN cord-309048-emmtplv3 181 17 neutralizing neutralize VBG cord-309048-emmtplv3 181 18 antibodies antibody NNS cord-309048-emmtplv3 181 19 in in IN cord-309048-emmtplv3 181 20 rats rat NNS cord-309048-emmtplv3 181 21 compared compare VBN cord-309048-emmtplv3 181 22 to to IN cord-309048-emmtplv3 181 23 the the DT cord-309048-emmtplv3 181 24 same same JJ cord-309048-emmtplv3 181 25 modified modify VBN cord-309048-emmtplv3 181 26 CP cp NN cord-309048-emmtplv3 181 27 that that WDT cord-309048-emmtplv3 181 28 had have VBD cord-309048-emmtplv3 181 29 been be VBN cord-309048-emmtplv3 181 30 disaggregated disaggregate VBN cord-309048-emmtplv3 181 31 by by IN cord-309048-emmtplv3 181 32 treatment treatment NN cord-309048-emmtplv3 181 33 at at IN cord-309048-emmtplv3 181 34 pH pH NNP cord-309048-emmtplv3 181 35 8.0 8.0 CD cord-309048-emmtplv3 181 36 , , , cord-309048-emmtplv3 181 37 indicating indicate VBG cord-309048-emmtplv3 181 38 the the DT cord-309048-emmtplv3 181 39 importance importance NN cord-309048-emmtplv3 181 40 of of IN cord-309048-emmtplv3 181 41 a a DT cord-309048-emmtplv3 181 42 repetitive repetitive JJ cord-309048-emmtplv3 181 43 structure structure NN cord-309048-emmtplv3 181 44 for for IN cord-309048-emmtplv3 181 45 the the DT cord-309048-emmtplv3 181 46 stimulation stimulation NN cord-309048-emmtplv3 181 47 of of IN cord-309048-emmtplv3 181 48 a a DT cord-309048-emmtplv3 181 49 strong strong JJ cord-309048-emmtplv3 181 50 immune immune JJ cord-309048-emmtplv3 181 51 reaction reaction NN cord-309048-emmtplv3 181 52 . . . cord-309048-emmtplv3 182 1 The the DT cord-309048-emmtplv3 182 2 authors author NNS cord-309048-emmtplv3 182 3 also also RB cord-309048-emmtplv3 182 4 stated state VBD cord-309048-emmtplv3 182 5 that that IN cord-309048-emmtplv3 182 6 the the DT cord-309048-emmtplv3 182 7 bacterially bacterially RB cord-309048-emmtplv3 182 8 expressed express VBN cord-309048-emmtplv3 182 9 protein protein NN cord-309048-emmtplv3 182 10 was be VBD cord-309048-emmtplv3 182 11 capable capable JJ cord-309048-emmtplv3 182 12 of of IN cord-309048-emmtplv3 182 13 assembly assembly NN cord-309048-emmtplv3 182 14 with with IN cord-309048-emmtplv3 182 15 added add VBN cord-309048-emmtplv3 182 16 TMV TMV NNP cord-309048-emmtplv3 182 17 RNA RNA NNP cord-309048-emmtplv3 182 18 in in IN cord-309048-emmtplv3 182 19 vitro vitro FW cord-309048-emmtplv3 182 20 , , , cord-309048-emmtplv3 182 21 though though IN cord-309048-emmtplv3 182 22 no no DT cord-309048-emmtplv3 182 23 data datum NNS cord-309048-emmtplv3 182 24 were be VBD cord-309048-emmtplv3 182 25 provided provide VBN cord-309048-emmtplv3 182 26 . . . cord-309048-emmtplv3 183 1 Expression expression NN cord-309048-emmtplv3 183 2 of of IN cord-309048-emmtplv3 183 3 TMV TMV NNP cord-309048-emmtplv3 183 4 CP CP NNP cord-309048-emmtplv3 183 5 in in IN cord-309048-emmtplv3 183 6 E. E. NNP cord-309048-emmtplv3 183 7 coli coli NNS cord-309048-emmtplv3 183 8 was be VBD cord-309048-emmtplv3 183 9 initially initially RB cord-309048-emmtplv3 183 10 considered consider VBN cord-309048-emmtplv3 183 11 to to TO cord-309048-emmtplv3 183 12 be be VB cord-309048-emmtplv3 183 13 a a DT cord-309048-emmtplv3 183 14 highly highly RB cord-309048-emmtplv3 183 15 promising promising JJ cord-309048-emmtplv3 183 16 method method NN cord-309048-emmtplv3 183 17 of of IN cord-309048-emmtplv3 183 18 producing produce VBG cord-309048-emmtplv3 183 19 variants variant NNS cord-309048-emmtplv3 183 20 that that WDT cord-309048-emmtplv3 183 21 could could MD cord-309048-emmtplv3 183 22 subsequently subsequently RB cord-309048-emmtplv3 183 23 be be VB cord-309048-emmtplv3 183 24 used use VBN cord-309048-emmtplv3 183 25 to to TO cord-309048-emmtplv3 183 26 generate generate VB cord-309048-emmtplv3 183 27 particles particle NNS cord-309048-emmtplv3 183 28 with with IN cord-309048-emmtplv3 183 29 varying vary VBG cord-309048-emmtplv3 183 30 properties property NNS cord-309048-emmtplv3 183 31 . . . cord-309048-emmtplv3 184 1 However however RB cord-309048-emmtplv3 184 2 , , , cord-309048-emmtplv3 184 3 Shire Shire NNP cord-309048-emmtplv3 184 4 et et NNP cord-309048-emmtplv3 184 5 al al NNP cord-309048-emmtplv3 184 6 . . . cord-309048-emmtplv3 185 1 ( ( -LRB- cord-309048-emmtplv3 185 2 1990 1990 CD cord-309048-emmtplv3 185 3 ) ) -RRB- cord-309048-emmtplv3 185 4 found find VBD cord-309048-emmtplv3 185 5 that that IN cord-309048-emmtplv3 185 6 wild wild JJ cord-309048-emmtplv3 185 7 - - HYPH cord-309048-emmtplv3 185 8 type type NN cord-309048-emmtplv3 185 9 TMV TMV NNP cord-309048-emmtplv3 185 10 CP CP NNP cord-309048-emmtplv3 185 11 produced produce VBN cord-309048-emmtplv3 185 12 in in IN cord-309048-emmtplv3 185 13 E. E. NNP cord-309048-emmtplv3 185 14 coli coli NNS cord-309048-emmtplv3 185 15 was be VBD cord-309048-emmtplv3 185 16 unable unable JJ cord-309048-emmtplv3 185 17 to to TO cord-309048-emmtplv3 185 18 assemble assemble VB cord-309048-emmtplv3 185 19 with with IN cord-309048-emmtplv3 185 20 TMV TMV NNP cord-309048-emmtplv3 185 21 RNA RNA NNP cord-309048-emmtplv3 185 22 in in IN cord-309048-emmtplv3 185 23 vitro vitro FW cord-309048-emmtplv3 185 24 , , , cord-309048-emmtplv3 185 25 a a DT cord-309048-emmtplv3 185 26 problem problem NN cord-309048-emmtplv3 185 27 also also RB cord-309048-emmtplv3 185 28 encountered encounter VBD cord-309048-emmtplv3 185 29 when when WRB cord-309048-emmtplv3 185 30 expression expression NN cord-309048-emmtplv3 185 31 of of IN cord-309048-emmtplv3 185 32 modified modify VBN cord-309048-emmtplv3 185 33 forms form NNS cord-309048-emmtplv3 185 34 of of IN cord-309048-emmtplv3 185 35 CP CP NNP cord-309048-emmtplv3 185 36 was be VBD cord-309048-emmtplv3 185 37 attempted attempt VBN cord-309048-emmtplv3 185 38 Wnek Wnek NNP cord-309048-emmtplv3 185 39 et et NNP cord-309048-emmtplv3 185 40 al al NNP cord-309048-emmtplv3 185 41 . . . cord-309048-emmtplv3 186 1 , , , cord-309048-emmtplv3 186 2 2013 2013 CD cord-309048-emmtplv3 186 3 ) ) -RRB- cord-309048-emmtplv3 186 4 . . . cord-309048-emmtplv3 187 1 The the DT cord-309048-emmtplv3 187 2 alternative alternative JJ cord-309048-emmtplv3 187 3 approach approach NN cord-309048-emmtplv3 187 4 of of IN cord-309048-emmtplv3 187 5 coexpressing coexpresse VBG cord-309048-emmtplv3 187 6 the the DT cord-309048-emmtplv3 187 7 CP CP NNP cord-309048-emmtplv3 187 8 and and CC cord-309048-emmtplv3 187 9 RNA RNA NNP cord-309048-emmtplv3 187 10 molecules molecule NNS cord-309048-emmtplv3 187 11 containing contain VBG cord-309048-emmtplv3 187 12 the the DT cord-309048-emmtplv3 187 13 OAS OAS NNP cord-309048-emmtplv3 187 14 within within IN cord-309048-emmtplv3 187 15 bacteria bacteria NNS cord-309048-emmtplv3 187 16 or or CC cord-309048-emmtplv3 187 17 yeast yeast NN cord-309048-emmtplv3 187 18 cells cell NNS cord-309048-emmtplv3 187 19 was be VBD cord-309048-emmtplv3 187 20 only only RB cord-309048-emmtplv3 187 21 partially partially RB cord-309048-emmtplv3 187 22 successful successful JJ cord-309048-emmtplv3 187 23 , , , cord-309048-emmtplv3 187 24 with with IN cord-309048-emmtplv3 187 25 only only RB cord-309048-emmtplv3 187 26 a a DT cord-309048-emmtplv3 187 27 small small JJ cord-309048-emmtplv3 187 28 number number NN cord-309048-emmtplv3 187 29 of of IN cord-309048-emmtplv3 187 30 virus virus NN cord-309048-emmtplv3 187 31 - - HYPH cord-309048-emmtplv3 187 32 like like JJ cord-309048-emmtplv3 187 33 particles particle NNS cord-309048-emmtplv3 187 34 or or CC cord-309048-emmtplv3 187 35 correctly correctly RB cord-309048-emmtplv3 187 36 formed form VBN cord-309048-emmtplv3 187 37 rods rod NNS cord-309048-emmtplv3 187 38 being be VBG cord-309048-emmtplv3 187 39 obtained obtain VBN cord-309048-emmtplv3 187 40 ( ( -LRB- cord-309048-emmtplv3 187 41 Hwang Hwang NNP cord-309048-emmtplv3 187 42 et et NNP cord-309048-emmtplv3 187 43 al al NNP cord-309048-emmtplv3 187 44 . . . cord-309048-emmtplv3 188 1 , , , cord-309048-emmtplv3 188 2 1994 1994 CD cord-309048-emmtplv3 188 3 ; ; : cord-309048-emmtplv3 188 4 Kadri Kadri NNP cord-309048-emmtplv3 188 5 et et NNP cord-309048-emmtplv3 188 6 al al NNP cord-309048-emmtplv3 188 7 . . NNP cord-309048-emmtplv3 188 8 , , , cord-309048-emmtplv3 188 9 2013 2013 CD cord-309048-emmtplv3 188 10 ) ) -RRB- cord-309048-emmtplv3 188 11 . . . cord-309048-emmtplv3 189 1 The the DT cord-309048-emmtplv3 189 2 aberrant aberrant JJ cord-309048-emmtplv3 189 3 assembly assembly NN cord-309048-emmtplv3 189 4 properties property NNS cord-309048-emmtplv3 189 5 of of IN cord-309048-emmtplv3 189 6 CP CP NNP cord-309048-emmtplv3 189 7 expressed express VBD cord-309048-emmtplv3 189 8 in in IN cord-309048-emmtplv3 189 9 bacteria bacteria NNS cord-309048-emmtplv3 189 10 have have VBP cord-309048-emmtplv3 189 11 been be VBN cord-309048-emmtplv3 189 12 ascribed ascribe VBN cord-309048-emmtplv3 189 13 to to IN cord-309048-emmtplv3 189 14 the the DT cord-309048-emmtplv3 189 15 lack lack NN cord-309048-emmtplv3 189 16 of of IN cord-309048-emmtplv3 189 17 acetylation acetylation NN cord-309048-emmtplv3 189 18 of of IN cord-309048-emmtplv3 189 19 the the DT cord-309048-emmtplv3 189 20 N n CD cord-309048-emmtplv3 189 21 - - HYPH cord-309048-emmtplv3 189 22 terminal terminal JJ cord-309048-emmtplv3 189 23 serine serine NN cord-309048-emmtplv3 189 24 , , , cord-309048-emmtplv3 189 25 which which WDT cord-309048-emmtplv3 189 26 prevents prevent VBZ cord-309048-emmtplv3 189 27 the the DT cord-309048-emmtplv3 189 28 formation formation NN cord-309048-emmtplv3 189 29 of of IN cord-309048-emmtplv3 189 30 the the DT cord-309048-emmtplv3 189 31 disk disk NN cord-309048-emmtplv3 189 32 structures structure NNS cord-309048-emmtplv3 189 33 necessary necessary JJ cord-309048-emmtplv3 189 34 to to TO cord-309048-emmtplv3 189 35 initiate initiate VB cord-309048-emmtplv3 189 36 the the DT cord-309048-emmtplv3 189 37 process process NN cord-309048-emmtplv3 189 38 ( ( -LRB- cord-309048-emmtplv3 189 39 Shire Shire NNP cord-309048-emmtplv3 189 40 et et NNP cord-309048-emmtplv3 189 41 al al NNP cord-309048-emmtplv3 189 42 . . NNP cord-309048-emmtplv3 189 43 , , , cord-309048-emmtplv3 189 44 1990 1990 CD cord-309048-emmtplv3 189 45 ; ; : cord-309048-emmtplv3 189 46 Wnek Wnek NNP cord-309048-emmtplv3 189 47 et et NNP cord-309048-emmtplv3 189 48 al al NNP cord-309048-emmtplv3 189 49 . . NNP cord-309048-emmtplv3 189 50 , , , cord-309048-emmtplv3 189 51 2013 2013 CD cord-309048-emmtplv3 189 52 ) ) -RRB- cord-309048-emmtplv3 189 53 . . . cord-309048-emmtplv3 190 1 This this DT cord-309048-emmtplv3 190 2 problem problem NN cord-309048-emmtplv3 190 3 could could MD cord-309048-emmtplv3 190 4 be be VB cord-309048-emmtplv3 190 5 alleviated alleviate VBN cord-309048-emmtplv3 190 6 by by IN cord-309048-emmtplv3 190 7 spiking spike VBG cord-309048-emmtplv3 190 8 the the DT cord-309048-emmtplv3 190 9 E. E. NNP cord-309048-emmtplv3 190 10 coli coli NNS cord-309048-emmtplv3 190 11 - - HYPH cord-309048-emmtplv3 190 12 produced produce VBN cord-309048-emmtplv3 190 13 protein protein NN cord-309048-emmtplv3 190 14 with with IN cord-309048-emmtplv3 190 15 a a DT cord-309048-emmtplv3 190 16 minimum minimum NN cord-309048-emmtplv3 190 17 of of IN cord-309048-emmtplv3 190 18 20 20 CD cord-309048-emmtplv3 190 19 % % NN cord-309048-emmtplv3 190 20 of of IN cord-309048-emmtplv3 190 21 plant plant NN cord-309048-emmtplv3 190 22 - - HYPH cord-309048-emmtplv3 190 23 made make VBN cord-309048-emmtplv3 190 24 TMV TMV NNP cord-309048-emmtplv3 190 25 CP CP NNP cord-309048-emmtplv3 190 26 , , , cord-309048-emmtplv3 190 27 an an DT cord-309048-emmtplv3 190 28 approach approach NN cord-309048-emmtplv3 190 29 that that WDT cord-309048-emmtplv3 190 30 enabled enable VBD cord-309048-emmtplv3 190 31 efficient efficient JJ cord-309048-emmtplv3 190 32 RNA RNA NNP cord-309048-emmtplv3 190 33 - - HYPH cord-309048-emmtplv3 190 34 guided guide VBN cord-309048-emmtplv3 190 35 assembly assembly NN cord-309048-emmtplv3 190 36 of of IN cord-309048-emmtplv3 190 37 TMV TMV NNP cord-309048-emmtplv3 190 38 - - HYPH cord-309048-emmtplv3 190 39 CP CP NNP cord-309048-emmtplv3 190 40 His6 His6 NNP cord-309048-emmtplv3 190 41 into into IN cord-309048-emmtplv3 190 42 particles particle NNS cord-309048-emmtplv3 190 43 of of IN cord-309048-emmtplv3 190 44 the the DT cord-309048-emmtplv3 190 45 expected expect VBN cord-309048-emmtplv3 190 46 length length NN cord-309048-emmtplv3 190 47 ( ( -LRB- cord-309048-emmtplv3 190 48 Eiben eiben FW cord-309048-emmtplv3 190 49 et et FW cord-309048-emmtplv3 190 50 al al NNP cord-309048-emmtplv3 190 51 . . . cord-309048-emmtplv3 191 1 , , , cord-309048-emmtplv3 191 2 2014 2014 CD cord-309048-emmtplv3 191 3 ) ) -RRB- cord-309048-emmtplv3 191 4 . . . cord-309048-emmtplv3 192 1 This this DT cord-309048-emmtplv3 192 2 approach approach NN cord-309048-emmtplv3 192 3 , , , cord-309048-emmtplv3 192 4 akin akin JJ cord-309048-emmtplv3 192 5 to to IN cord-309048-emmtplv3 192 6 the the DT cord-309048-emmtplv3 192 7 production production NN cord-309048-emmtplv3 192 8 of of IN cord-309048-emmtplv3 192 9 mosaic mosaic JJ cord-309048-emmtplv3 192 10 particles particle NNS cord-309048-emmtplv3 192 11 in in IN cord-309048-emmtplv3 192 12 plants plant NNS cord-309048-emmtplv3 192 13 , , , cord-309048-emmtplv3 192 14 provides provide VBZ cord-309048-emmtplv3 192 15 a a DT cord-309048-emmtplv3 192 16 further further JJ cord-309048-emmtplv3 192 17 option option NN cord-309048-emmtplv3 192 18 for for IN cord-309048-emmtplv3 192 19 tailoring tailor VBG cord-309048-emmtplv3 192 20 the the DT cord-309048-emmtplv3 192 21 properties property NNS cord-309048-emmtplv3 192 22 and and CC cord-309048-emmtplv3 192 23 addressability addressability NN cord-309048-emmtplv3 192 24 of of IN cord-309048-emmtplv3 192 25 TMV TMV NNP cord-309048-emmtplv3 192 26 - - HYPH cord-309048-emmtplv3 192 27 like like JJ cord-309048-emmtplv3 192 28 particles particle NNS cord-309048-emmtplv3 192 29 assembled assemble VBN cord-309048-emmtplv3 192 30 in in IN cord-309048-emmtplv3 192 31 vitro vitro FW cord-309048-emmtplv3 192 32 . . . cord-309048-emmtplv3 193 1 Bacterial bacterial JJ cord-309048-emmtplv3 193 2 production production NN cord-309048-emmtplv3 193 3 has have VBZ cord-309048-emmtplv3 193 4 been be VBN cord-309048-emmtplv3 193 5 successfully successfully RB cord-309048-emmtplv3 193 6 used use VBN cord-309048-emmtplv3 193 7 to to TO cord-309048-emmtplv3 193 8 produce produce VB cord-309048-emmtplv3 193 9 a a DT cord-309048-emmtplv3 193 10 number number NN cord-309048-emmtplv3 193 11 of of IN cord-309048-emmtplv3 193 12 CP cp NN cord-309048-emmtplv3 193 13 variants variant NNS cord-309048-emmtplv3 193 14 . . . cord-309048-emmtplv3 194 1 For for IN cord-309048-emmtplv3 194 2 example example NN cord-309048-emmtplv3 194 3 , , , cord-309048-emmtplv3 194 4 expression expression NN cord-309048-emmtplv3 194 5 of of IN cord-309048-emmtplv3 194 6 mutant mutant JJ cord-309048-emmtplv3 194 7 T103C T103C NNP cord-309048-emmtplv3 194 8 allowed allow VBD cord-309048-emmtplv3 194 9 the the DT cord-309048-emmtplv3 194 10 formation formation NN cord-309048-emmtplv3 194 11 of of IN cord-309048-emmtplv3 194 12 disulfide disulfide JJ cord-309048-emmtplv3 194 13 bonds bond NNS cord-309048-emmtplv3 194 14 between between IN cord-309048-emmtplv3 194 15 the the DT cord-309048-emmtplv3 194 16 exposed expose VBN cord-309048-emmtplv3 194 17 loops loop NNS cord-309048-emmtplv3 194 18 of of IN cord-309048-emmtplv3 194 19 adjacent adjacent JJ cord-309048-emmtplv3 194 20 subunits subunit NNS cord-309048-emmtplv3 194 21 in in IN cord-309048-emmtplv3 194 22 the the DT cord-309048-emmtplv3 194 23 central central JJ cord-309048-emmtplv3 194 24 channel channel NN cord-309048-emmtplv3 194 25 of of IN cord-309048-emmtplv3 194 26 assembled assemble VBN cord-309048-emmtplv3 194 27 TMV TMV NNP cord-309048-emmtplv3 194 28 - - HYPH cord-309048-emmtplv3 194 29 like like JJ cord-309048-emmtplv3 194 30 nanotubes nanotube NNS cord-309048-emmtplv3 195 1 ( ( -LRB- cord-309048-emmtplv3 195 2 Zhou Zhou NNP cord-309048-emmtplv3 195 3 et et NNP cord-309048-emmtplv3 195 4 al al NNP cord-309048-emmtplv3 195 5 . . NNP cord-309048-emmtplv3 195 6 , , , cord-309048-emmtplv3 195 7 2013 2013 CD cord-309048-emmtplv3 195 8 ) ) -RRB- cord-309048-emmtplv3 195 9 . . . cord-309048-emmtplv3 196 1 This this DT cord-309048-emmtplv3 196 2 expanded expand VBD cord-309048-emmtplv3 196 3 the the DT cord-309048-emmtplv3 196 4 spectrum spectrum NN cord-309048-emmtplv3 196 5 of of IN cord-309048-emmtplv3 196 6 metal metal NN cord-309048-emmtplv3 196 7 fabrication fabrication NN cord-309048-emmtplv3 196 8 within within IN cord-309048-emmtplv3 196 9 the the DT cord-309048-emmtplv3 196 10 channel channel NN cord-309048-emmtplv3 196 11 to to TO cord-309048-emmtplv3 196 12 include include VB cord-309048-emmtplv3 196 13 gold gold NN cord-309048-emmtplv3 196 14 nanobeads nanobead NNS cord-309048-emmtplv3 196 15 and and CC cord-309048-emmtplv3 196 16 -rods -rods . cord-309048-emmtplv3 197 1 ( ( -LRB- cord-309048-emmtplv3 197 2 Zhou Zhou NNP cord-309048-emmtplv3 197 3 et et NNP cord-309048-emmtplv3 197 4 al al NNP cord-309048-emmtplv3 197 5 . . NNP cord-309048-emmtplv3 197 6 , , , cord-309048-emmtplv3 197 7 2015 2015 CD cord-309048-emmtplv3 197 8 ) ) -RRB- cord-309048-emmtplv3 197 9 . . . cord-309048-emmtplv3 198 1 Likewise likewise RB cord-309048-emmtplv3 198 2 , , , cord-309048-emmtplv3 198 3 Finbloom Finbloom NNP cord-309048-emmtplv3 198 4 et et NNP cord-309048-emmtplv3 198 5 al al NNP cord-309048-emmtplv3 198 6 . . . cord-309048-emmtplv3 199 1 ( ( -LRB- cord-309048-emmtplv3 199 2 2016 2016 CD cord-309048-emmtplv3 199 3 ) ) -RRB- cord-309048-emmtplv3 199 4 produced produce VBD cord-309048-emmtplv3 199 5 a a DT cord-309048-emmtplv3 199 6 mutant mutant JJ cord-309048-emmtplv3 199 7 CP cp NN cord-309048-emmtplv3 199 8 in in IN cord-309048-emmtplv3 199 9 E. E. NNP cord-309048-emmtplv3 199 10 coli coli NNS cord-309048-emmtplv3 199 11 in in IN cord-309048-emmtplv3 199 12 which which WDT cord-309048-emmtplv3 199 13 two two CD cord-309048-emmtplv3 199 14 lysine lysine NN cord-309048-emmtplv3 199 15 residues residue NNS cord-309048-emmtplv3 199 16 ( ( -LRB- cord-309048-emmtplv3 199 17 positions position NNS cord-309048-emmtplv3 199 18 53 53 CD cord-309048-emmtplv3 199 19 and and CC cord-309048-emmtplv3 199 20 68 68 CD cord-309048-emmtplv3 199 21 ) ) -RRB- cord-309048-emmtplv3 199 22 were be VBD cord-309048-emmtplv3 199 23 mutated mutate VBN cord-309048-emmtplv3 199 24 to to IN cord-309048-emmtplv3 199 25 arginines arginine NNS cord-309048-emmtplv3 199 26 . . . cord-309048-emmtplv3 200 1 The the DT cord-309048-emmtplv3 200 2 modified modify VBN cord-309048-emmtplv3 200 3 CP CP NNP cord-309048-emmtplv3 200 4 was be VBD cord-309048-emmtplv3 200 5 able able JJ cord-309048-emmtplv3 200 6 to to TO cord-309048-emmtplv3 200 7 form form VB cord-309048-emmtplv3 200 8 stable stable JJ cord-309048-emmtplv3 200 9 disk disk NN cord-309048-emmtplv3 200 10 structures structure NNS cord-309048-emmtplv3 200 11 that that WDT cord-309048-emmtplv3 200 12 were be VBD cord-309048-emmtplv3 200 13 subsequently subsequently RB cord-309048-emmtplv3 200 14 modified modify VBN cord-309048-emmtplv3 200 15 for for IN cord-309048-emmtplv3 200 16 drug drug NN cord-309048-emmtplv3 200 17 delivery delivery NN cord-309048-emmtplv3 200 18 purposes purpose NNS cord-309048-emmtplv3 200 19 . . . cord-309048-emmtplv3 201 1 The the DT cord-309048-emmtplv3 201 2 first first JJ cord-309048-emmtplv3 201 3 attempt attempt NN cord-309048-emmtplv3 201 4 to to TO cord-309048-emmtplv3 201 5 produce produce VB cord-309048-emmtplv3 201 6 the the DT cord-309048-emmtplv3 201 7 TMV TMV NNP cord-309048-emmtplv3 201 8 CP CP NNP cord-309048-emmtplv3 201 9 in in IN cord-309048-emmtplv3 201 10 plants plant NNS cord-309048-emmtplv3 201 11 involved involve VBD cord-309048-emmtplv3 201 12 the the DT cord-309048-emmtplv3 201 13 transformation transformation NN cord-309048-emmtplv3 201 14 of of IN cord-309048-emmtplv3 201 15 tobacco tobacco NN cord-309048-emmtplv3 201 16 plants plant NNS cord-309048-emmtplv3 201 17 with with IN cord-309048-emmtplv3 201 18 a a DT cord-309048-emmtplv3 201 19 copy copy NN cord-309048-emmtplv3 201 20 of of IN cord-309048-emmtplv3 201 21 the the DT cord-309048-emmtplv3 201 22 CP cp NN cord-309048-emmtplv3 201 23 , , , cord-309048-emmtplv3 201 24 with with IN cord-309048-emmtplv3 201 25 expression expression NN cord-309048-emmtplv3 201 26 being be VBG cord-309048-emmtplv3 201 27 driven drive VBN cord-309048-emmtplv3 201 28 by by IN cord-309048-emmtplv3 201 29 the the DT cord-309048-emmtplv3 201 30 cauliflower cauliflower NNP cord-309048-emmtplv3 201 31 mosaic mosaic NNP cord-309048-emmtplv3 201 32 virus virus NN cord-309048-emmtplv3 201 33 35S 35S NNP cord-309048-emmtplv3 201 34 promoter promoter NN cord-309048-emmtplv3 201 35 ( ( -LRB- cord-309048-emmtplv3 201 36 Bevan Bevan NNP cord-309048-emmtplv3 201 37 et et NNP cord-309048-emmtplv3 201 38 al al NNP cord-309048-emmtplv3 201 39 . . NNP cord-309048-emmtplv3 201 40 , , , cord-309048-emmtplv3 201 41 1985 1985 CD cord-309048-emmtplv3 201 42 ) ) -RRB- cord-309048-emmtplv3 201 43 . . . cord-309048-emmtplv3 202 1 Although although IN cord-309048-emmtplv3 202 2 CP CP NNP cord-309048-emmtplv3 202 3 was be VBD cord-309048-emmtplv3 202 4 detected detect VBN cord-309048-emmtplv3 202 5 immunologically immunologically RB cord-309048-emmtplv3 202 6 , , , cord-309048-emmtplv3 202 7 no no DT cord-309048-emmtplv3 202 8 attempt attempt NN cord-309048-emmtplv3 202 9 was be VBD cord-309048-emmtplv3 202 10 made make VBN cord-309048-emmtplv3 202 11 to to TO cord-309048-emmtplv3 202 12 assess assess VB cord-309048-emmtplv3 202 13 its -PRON- PRP$ cord-309048-emmtplv3 202 14 aggregation aggregation NN cord-309048-emmtplv3 202 15 state state NN cord-309048-emmtplv3 202 16 . . . cord-309048-emmtplv3 203 1 It -PRON- PRP cord-309048-emmtplv3 203 2 soon soon RB cord-309048-emmtplv3 203 3 transpired transpire VBD cord-309048-emmtplv3 203 4 that that DT cord-309048-emmtplv3 203 5 tobacco tobacco NN cord-309048-emmtplv3 203 6 plants plant NNS cord-309048-emmtplv3 203 7 transgenic transgenic JJ cord-309048-emmtplv3 203 8 for for IN cord-309048-emmtplv3 203 9 the the DT cord-309048-emmtplv3 203 10 TMV TMV NNP cord-309048-emmtplv3 203 11 CP CP NNP cord-309048-emmtplv3 203 12 were be VBD cord-309048-emmtplv3 203 13 resistant resistant JJ cord-309048-emmtplv3 203 14 to to IN cord-309048-emmtplv3 203 15 subsequent subsequent JJ cord-309048-emmtplv3 203 16 challenge challenge NN cord-309048-emmtplv3 203 17 with with IN cord-309048-emmtplv3 203 18 virus virus NN cord-309048-emmtplv3 203 19 ( ( -LRB- cord-309048-emmtplv3 204 1 Powell Powell NNP cord-309048-emmtplv3 204 2 Abel Abel NNP cord-309048-emmtplv3 204 3 et et NNP cord-309048-emmtplv3 204 4 al al NNP cord-309048-emmtplv3 204 5 . . NNP cord-309048-emmtplv3 204 6 , , , cord-309048-emmtplv3 204 7 1986 1986 CD cord-309048-emmtplv3 204 8 ) ) -RRB- cord-309048-emmtplv3 204 9 , , , cord-309048-emmtplv3 204 10 and and CC cord-309048-emmtplv3 204 11 the the DT cord-309048-emmtplv3 204 12 concept concept NN cord-309048-emmtplv3 204 13 of of IN cord-309048-emmtplv3 204 14 " " `` cord-309048-emmtplv3 204 15 coat coat NN cord-309048-emmtplv3 204 16 protein protein NN cord-309048-emmtplv3 204 17 - - HYPH cord-309048-emmtplv3 204 18 mediated mediate VBN cord-309048-emmtplv3 204 19 resistance resistance NN cord-309048-emmtplv3 204 20 " " '' cord-309048-emmtplv3 204 21 was be VBD cord-309048-emmtplv3 204 22 born bear VBN cord-309048-emmtplv3 204 23 ( ( -LRB- cord-309048-emmtplv3 204 24 Beachy Beachy NNP cord-309048-emmtplv3 204 25 , , , cord-309048-emmtplv3 204 26 1999 1999 CD cord-309048-emmtplv3 204 27 ) ) -RRB- cord-309048-emmtplv3 204 28 . . . cord-309048-emmtplv3 205 1 As as IN cord-309048-emmtplv3 205 2 part part NN cord-309048-emmtplv3 205 3 of of IN cord-309048-emmtplv3 205 4 their -PRON- PRP$ cord-309048-emmtplv3 205 5 studies study NNS cord-309048-emmtplv3 205 6 on on IN cord-309048-emmtplv3 205 7 the the DT cord-309048-emmtplv3 205 8 mechanism mechanism NN cord-309048-emmtplv3 205 9 of of IN cord-309048-emmtplv3 205 10 CP cp NN cord-309048-emmtplv3 205 11 - - HYPH cord-309048-emmtplv3 205 12 mediated mediate VBN cord-309048-emmtplv3 205 13 resistance resistance NN cord-309048-emmtplv3 205 14 , , , cord-309048-emmtplv3 205 15 Asurmendi Asurmendi NNP cord-309048-emmtplv3 205 16 et et NNP cord-309048-emmtplv3 205 17 al al NNP cord-309048-emmtplv3 205 18 . . . cord-309048-emmtplv3 206 1 ( ( -LRB- cord-309048-emmtplv3 206 2 2007 2007 CD cord-309048-emmtplv3 206 3 ) ) -RRB- cord-309048-emmtplv3 206 4 examined examine VBD cord-309048-emmtplv3 206 5 the the DT cord-309048-emmtplv3 206 6 aggregation aggregation NN cord-309048-emmtplv3 206 7 state state NN cord-309048-emmtplv3 206 8 of of IN cord-309048-emmtplv3 206 9 the the DT cord-309048-emmtplv3 206 10 TMV TMV NNP cord-309048-emmtplv3 206 11 CP CP NNP cord-309048-emmtplv3 206 12 in in IN cord-309048-emmtplv3 206 13 transgenic transgenic JJ cord-309048-emmtplv3 206 14 tobacco tobacco NN cord-309048-emmtplv3 206 15 and and CC cord-309048-emmtplv3 206 16 showed show VBD cord-309048-emmtplv3 206 17 that that IN cord-309048-emmtplv3 206 18 the the DT cord-309048-emmtplv3 206 19 subunits subunit NNS cord-309048-emmtplv3 206 20 formed form VBD cord-309048-emmtplv3 206 21 higher high JJR cord-309048-emmtplv3 206 22 aggregates aggregate NNS cord-309048-emmtplv3 206 23 , , , cord-309048-emmtplv3 206 24 suggesting suggest VBG cord-309048-emmtplv3 206 25 that that IN cord-309048-emmtplv3 206 26 they -PRON- PRP cord-309048-emmtplv3 206 27 are be VBP cord-309048-emmtplv3 206 28 assembly assembly NN cord-309048-emmtplv3 206 29 competent competent JJ cord-309048-emmtplv3 206 30 . . . cord-309048-emmtplv3 207 1 However however RB cord-309048-emmtplv3 207 2 , , , cord-309048-emmtplv3 207 3 the the DT cord-309048-emmtplv3 207 4 levels level NNS cord-309048-emmtplv3 207 5 of of IN cord-309048-emmtplv3 207 6 CP cp NN cord-309048-emmtplv3 207 7 produced produce VBN cord-309048-emmtplv3 207 8 in in IN cord-309048-emmtplv3 207 9 transgenic transgenic JJ cord-309048-emmtplv3 207 10 plants plant NNS cord-309048-emmtplv3 207 11 were be VBD cord-309048-emmtplv3 207 12 too too RB cord-309048-emmtplv3 207 13 low low JJ cord-309048-emmtplv3 207 14 for for IN cord-309048-emmtplv3 207 15 this this DT cord-309048-emmtplv3 207 16 system system NN cord-309048-emmtplv3 207 17 to to TO cord-309048-emmtplv3 207 18 be be VB cord-309048-emmtplv3 207 19 considered consider VBN cord-309048-emmtplv3 207 20 a a DT cord-309048-emmtplv3 207 21 practical practical JJ cord-309048-emmtplv3 207 22 method method NN cord-309048-emmtplv3 207 23 of of IN cord-309048-emmtplv3 207 24 CP cp NN cord-309048-emmtplv3 207 25 production production NN cord-309048-emmtplv3 207 26 . . . cord-309048-emmtplv3 208 1 To to TO cord-309048-emmtplv3 208 2 increase increase VB cord-309048-emmtplv3 208 3 the the DT cord-309048-emmtplv3 208 4 levels level NNS cord-309048-emmtplv3 208 5 of of IN cord-309048-emmtplv3 208 6 TMV TMV NNP cord-309048-emmtplv3 208 7 CP CP NNP cord-309048-emmtplv3 208 8 in in IN cord-309048-emmtplv3 208 9 plants plant NNS cord-309048-emmtplv3 208 10 , , , cord-309048-emmtplv3 208 11 Saunders Saunders NNP cord-309048-emmtplv3 208 12 and and CC cord-309048-emmtplv3 208 13 Lomonossoff Lomonossoff NNP cord-309048-emmtplv3 208 14 ( ( -LRB- cord-309048-emmtplv3 208 15 2017 2017 CD cord-309048-emmtplv3 208 16 ) ) -RRB- cord-309048-emmtplv3 208 17 used use VBN cord-309048-emmtplv3 208 18 transient transient JJ cord-309048-emmtplv3 208 19 expression expression NN cord-309048-emmtplv3 208 20 of of IN cord-309048-emmtplv3 208 21 the the DT cord-309048-emmtplv3 208 22 CP cp NN cord-309048-emmtplv3 208 23 coding coding NN cord-309048-emmtplv3 208 24 sequence sequence NN cord-309048-emmtplv3 208 25 in in IN cord-309048-emmtplv3 208 26 Nicotiana Nicotiana NNP cord-309048-emmtplv3 208 27 benthamiana benthamiana NNP cord-309048-emmtplv3 208 28 . . . cord-309048-emmtplv3 209 1 No no DT cord-309048-emmtplv3 209 2 detectable detectable JJ cord-309048-emmtplv3 209 3 material material NN cord-309048-emmtplv3 209 4 accumulated accumulate VBN cord-309048-emmtplv3 209 5 when when WRB cord-309048-emmtplv3 209 6 the the DT cord-309048-emmtplv3 209 7 CP cp NN cord-309048-emmtplv3 209 8 was be VBD cord-309048-emmtplv3 209 9 expressed express VBN cord-309048-emmtplv3 209 10 alone alone RB cord-309048-emmtplv3 209 11 , , , cord-309048-emmtplv3 209 12 indicating indicate VBG cord-309048-emmtplv3 209 13 that that IN cord-309048-emmtplv3 209 14 assembly assembly NN cord-309048-emmtplv3 209 15 is be VBZ cord-309048-emmtplv3 209 16 crucial crucial JJ cord-309048-emmtplv3 209 17 for for IN cord-309048-emmtplv3 209 18 CP cp NN cord-309048-emmtplv3 209 19 accumulation accumulation NN cord-309048-emmtplv3 209 20 in in IN cord-309048-emmtplv3 209 21 plants plant NNS cord-309048-emmtplv3 209 22 . . . cord-309048-emmtplv3 210 1 However however RB cord-309048-emmtplv3 210 2 , , , cord-309048-emmtplv3 210 3 when when WRB cord-309048-emmtplv3 210 4 the the DT cord-309048-emmtplv3 210 5 CP CP NNP cord-309048-emmtplv3 210 6 was be VBD cord-309048-emmtplv3 210 7 expressed express VBN cord-309048-emmtplv3 210 8 in in IN cord-309048-emmtplv3 210 9 the the DT cord-309048-emmtplv3 210 10 presence presence NN cord-309048-emmtplv3 210 11 of of IN cord-309048-emmtplv3 210 12 RNA RNA NNP cord-309048-emmtplv3 210 13 molecules molecule NNS cord-309048-emmtplv3 210 14 containing contain VBG cord-309048-emmtplv3 210 15 the the DT cord-309048-emmtplv3 210 16 OAS OAS NNP cord-309048-emmtplv3 210 17 , , , cord-309048-emmtplv3 210 18 virus virus NN cord-309048-emmtplv3 210 19 - - HYPH cord-309048-emmtplv3 210 20 like like JJ cord-309048-emmtplv3 210 21 rods rod NNS cord-309048-emmtplv3 210 22 readily readily RB cord-309048-emmtplv3 210 23 formed form VBN cord-309048-emmtplv3 210 24 , , , cord-309048-emmtplv3 210 25 the the DT cord-309048-emmtplv3 210 26 length length NN cord-309048-emmtplv3 210 27 of of IN cord-309048-emmtplv3 210 28 which which WDT cord-309048-emmtplv3 210 29 was be VBD cord-309048-emmtplv3 210 30 controlled control VBN cord-309048-emmtplv3 210 31 by by IN cord-309048-emmtplv3 210 32 the the DT cord-309048-emmtplv3 210 33 length length NN cord-309048-emmtplv3 210 34 of of IN cord-309048-emmtplv3 210 35 the the DT cord-309048-emmtplv3 210 36 RNA RNA NNP cord-309048-emmtplv3 210 37 . . . cord-309048-emmtplv3 211 1 Furthermore furthermore RB cord-309048-emmtplv3 211 2 , , , cord-309048-emmtplv3 211 3 it -PRON- PRP cord-309048-emmtplv3 211 4 was be VBD cord-309048-emmtplv3 211 5 possible possible JJ cord-309048-emmtplv3 211 6 to to TO cord-309048-emmtplv3 211 7 fuse fuse VB cord-309048-emmtplv3 211 8 a a DT cord-309048-emmtplv3 211 9 nine nine CD cord-309048-emmtplv3 211 10 - - HYPH cord-309048-emmtplv3 211 11 amino amino NN cord-309048-emmtplv3 211 12 acid acid NN cord-309048-emmtplv3 211 13 cobalt cobalt NN cord-309048-emmtplv3 211 14 - - HYPH cord-309048-emmtplv3 211 15 platinum platinum NN cord-309048-emmtplv3 211 16 ( ( -LRB- cord-309048-emmtplv3 211 17 CoPt)-binding copt)-binde VBG cord-309048-emmtplv3 211 18 peptide peptide JJ cord-309048-emmtplv3 211 19 to to IN cord-309048-emmtplv3 211 20 the the DT cord-309048-emmtplv3 211 21 C c NN cord-309048-emmtplv3 211 22 - - HYPH cord-309048-emmtplv3 211 23 terminus terminus NN cord-309048-emmtplv3 211 24 of of IN cord-309048-emmtplv3 211 25 the the DT cord-309048-emmtplv3 211 26 CP cp NN cord-309048-emmtplv3 211 27 without without IN cord-309048-emmtplv3 211 28 abolishing abolish VBG cord-309048-emmtplv3 211 29 particle particle NN cord-309048-emmtplv3 211 30 assembly assembly NN cord-309048-emmtplv3 211 31 in in IN cord-309048-emmtplv3 211 32 planta planta NNP cord-309048-emmtplv3 211 33 . . . cord-309048-emmtplv3 212 1 CoPt CoPt NNP cord-309048-emmtplv3 212 2 could could MD cord-309048-emmtplv3 212 3 be be VB cord-309048-emmtplv3 212 4 deposited deposit VBN cord-309048-emmtplv3 212 5 on on IN cord-309048-emmtplv3 212 6 the the DT cord-309048-emmtplv3 212 7 surface surface NN cord-309048-emmtplv3 212 8 of of IN cord-309048-emmtplv3 212 9 particles particle NNS cord-309048-emmtplv3 212 10 harboring harbor VBG cord-309048-emmtplv3 212 11 the the DT cord-309048-emmtplv3 212 12 peptide peptide NN cord-309048-emmtplv3 212 13 but but CC cord-309048-emmtplv3 212 14 not not RB cord-309048-emmtplv3 212 15 on on IN cord-309048-emmtplv3 212 16 particles particle NNS cord-309048-emmtplv3 212 17 containing contain VBG cord-309048-emmtplv3 212 18 wild wild JJ cord-309048-emmtplv3 212 19 - - HYPH cord-309048-emmtplv3 212 20 type type NN cord-309048-emmtplv3 212 21 CP cp NN cord-309048-emmtplv3 212 22 . . . cord-309048-emmtplv3 213 1 Thus thus RB cord-309048-emmtplv3 213 2 , , , cord-309048-emmtplv3 213 3 plant plant NN cord-309048-emmtplv3 213 4 - - HYPH cord-309048-emmtplv3 213 5 based base VBN cord-309048-emmtplv3 213 6 expression expression NN cord-309048-emmtplv3 213 7 may may MD cord-309048-emmtplv3 213 8 be be VB cord-309048-emmtplv3 213 9 an an DT cord-309048-emmtplv3 213 10 effective effective JJ cord-309048-emmtplv3 213 11 approach approach NN cord-309048-emmtplv3 213 12 to to IN cord-309048-emmtplv3 213 13 the the DT cord-309048-emmtplv3 213 14 creation creation NN cord-309048-emmtplv3 213 15 of of IN cord-309048-emmtplv3 213 16 defined define VBN cord-309048-emmtplv3 213 17 - - HYPH cord-309048-emmtplv3 213 18 length length NN cord-309048-emmtplv3 213 19 conducting conduct VBG cord-309048-emmtplv3 213 20 nanowires nanowire NNS cord-309048-emmtplv3 213 21 . . . cord-309048-emmtplv3 214 1 Mueller Mueller NNP cord-309048-emmtplv3 214 2 et et NNP cord-309048-emmtplv3 214 3 al al NNP cord-309048-emmtplv3 214 4 . . . cord-309048-emmtplv3 215 1 ( ( -LRB- cord-309048-emmtplv3 215 2 2011 2011 CD cord-309048-emmtplv3 215 3 ) ) -RRB- cord-309048-emmtplv3 215 4 demonstrated demonstrate VBD cord-309048-emmtplv3 215 5 that that IN cord-309048-emmtplv3 215 6 it -PRON- PRP cord-309048-emmtplv3 215 7 is be VBZ cord-309048-emmtplv3 215 8 possible possible JJ cord-309048-emmtplv3 215 9 to to TO cord-309048-emmtplv3 215 10 express express VB cord-309048-emmtplv3 215 11 both both DT cord-309048-emmtplv3 215 12 wildtype wildtype JJ cord-309048-emmtplv3 215 13 and and CC cord-309048-emmtplv3 215 14 variant variant JJ cord-309048-emmtplv3 215 15 versions version NNS cord-309048-emmtplv3 215 16 of of IN cord-309048-emmtplv3 215 17 TMV TMV NNP cord-309048-emmtplv3 215 18 CP CP NNP cord-309048-emmtplv3 215 19 in in IN cord-309048-emmtplv3 215 20 the the DT cord-309048-emmtplv3 215 21 yeast yeast NN cord-309048-emmtplv3 215 22 , , , cord-309048-emmtplv3 215 23 Schizosaccharomyces Schizosaccharomyces NNP cord-309048-emmtplv3 215 24 pombe pombe NN cord-309048-emmtplv3 215 25 , , , cord-309048-emmtplv3 215 26 and and CC cord-309048-emmtplv3 215 27 the the DT cord-309048-emmtplv3 215 28 yeast yeast NN cord-309048-emmtplv3 215 29 - - HYPH cord-309048-emmtplv3 215 30 expressed express VBN cord-309048-emmtplv3 215 31 CP CP NNP cord-309048-emmtplv3 215 32 retained retain VBD cord-309048-emmtplv3 215 33 its -PRON- PRP$ cord-309048-emmtplv3 215 34 ability ability NN cord-309048-emmtplv3 215 35 to to TO cord-309048-emmtplv3 215 36 assemble assemble VB cord-309048-emmtplv3 215 37 with with IN cord-309048-emmtplv3 215 38 TMV TMV NNP cord-309048-emmtplv3 215 39 RNA RNA NNP cord-309048-emmtplv3 215 40 in in IN cord-309048-emmtplv3 215 41 vitro vitro FW cord-309048-emmtplv3 215 42 . . . cord-309048-emmtplv3 216 1 Subsequently subsequently RB cord-309048-emmtplv3 216 2 , , , cord-309048-emmtplv3 216 3 Kadri Kadri NNP cord-309048-emmtplv3 216 4 et et NNP cord-309048-emmtplv3 216 5 al al NNP cord-309048-emmtplv3 216 6 . . . cord-309048-emmtplv3 217 1 ( ( -LRB- cord-309048-emmtplv3 217 2 2013 2013 CD cord-309048-emmtplv3 217 3 ) ) -RRB- cord-309048-emmtplv3 217 4 demonstrated demonstrate VBD cord-309048-emmtplv3 217 5 the the DT cord-309048-emmtplv3 217 6 ability ability NN cord-309048-emmtplv3 217 7 of of IN cord-309048-emmtplv3 217 8 the the DT cord-309048-emmtplv3 217 9 yeast yeast NN cord-309048-emmtplv3 217 10 - - HYPH cord-309048-emmtplv3 217 11 expressed express VBN cord-309048-emmtplv3 217 12 material material NN cord-309048-emmtplv3 217 13 to to TO cord-309048-emmtplv3 217 14 assemble assemble VB cord-309048-emmtplv3 217 15 with with IN cord-309048-emmtplv3 217 16 coexpressed coexpresse VBN cord-309048-emmtplv3 217 17 OAS OAS NNP cord-309048-emmtplv3 217 18 - - HYPH cord-309048-emmtplv3 217 19 containing contain VBG cord-309048-emmtplv3 217 20 RNA RNA NNP cord-309048-emmtplv3 217 21 similarly similarly RB cord-309048-emmtplv3 217 22 to to IN cord-309048-emmtplv3 217 23 CP CP NNP cord-309048-emmtplv3 217 24 coexpressed coexpresse VBN cord-309048-emmtplv3 217 25 with with IN cord-309048-emmtplv3 217 26 RNA RNA NNP cord-309048-emmtplv3 217 27 in in IN cord-309048-emmtplv3 217 28 E. E. NNP cord-309048-emmtplv3 217 29 coli coli NNS cord-309048-emmtplv3 217 30 . . . cord-309048-emmtplv3 218 1 The the DT cord-309048-emmtplv3 218 2 results result NNS cord-309048-emmtplv3 218 3 suggested suggest VBD cord-309048-emmtplv3 218 4 that that IN cord-309048-emmtplv3 218 5 the the DT cord-309048-emmtplv3 218 6 yeast yeast NN cord-309048-emmtplv3 218 7 - - HYPH cord-309048-emmtplv3 218 8 expressed express VBN cord-309048-emmtplv3 218 9 CP CP NNP cord-309048-emmtplv3 218 10 was be VBD cord-309048-emmtplv3 218 11 more more RBR cord-309048-emmtplv3 218 12 similar similar JJ cord-309048-emmtplv3 218 13 to to IN cord-309048-emmtplv3 218 14 that that DT cord-309048-emmtplv3 218 15 expressed express VBN cord-309048-emmtplv3 218 16 in in IN cord-309048-emmtplv3 218 17 plants plant NNS cord-309048-emmtplv3 218 18 than than IN cord-309048-emmtplv3 218 19 was be VBD cord-309048-emmtplv3 218 20 CP CP NNP cord-309048-emmtplv3 218 21 expressed express VBN cord-309048-emmtplv3 218 22 in in IN cord-309048-emmtplv3 218 23 bacteria bacteria NNS cord-309048-emmtplv3 218 24 , , , cord-309048-emmtplv3 218 25 probably probably RB cord-309048-emmtplv3 218 26 as as IN cord-309048-emmtplv3 218 27 a a DT cord-309048-emmtplv3 218 28 result result NN cord-309048-emmtplv3 218 29 of of IN cord-309048-emmtplv3 218 30 the the DT cord-309048-emmtplv3 218 31 correct correct JJ cord-309048-emmtplv3 218 32 acetylation acetylation NN cord-309048-emmtplv3 218 33 of of IN cord-309048-emmtplv3 218 34 the the DT cord-309048-emmtplv3 218 35 N N NNP cord-309048-emmtplv3 218 36 - - HYPH cord-309048-emmtplv3 218 37 terminus terminus NN cord-309048-emmtplv3 218 38 . . . cord-309048-emmtplv3 219 1 Experiments experiment NNS cord-309048-emmtplv3 219 2 designed design VBN cord-309048-emmtplv3 219 3 to to TO cord-309048-emmtplv3 219 4 develop develop VB cord-309048-emmtplv3 219 5 an an DT cord-309048-emmtplv3 219 6 efficient efficient JJ cord-309048-emmtplv3 219 7 TMV tmv NN cord-309048-emmtplv3 219 8 - - HYPH cord-309048-emmtplv3 219 9 based base VBN cord-309048-emmtplv3 219 10 VIGS vigs NN cord-309048-emmtplv3 219 11 system system NN cord-309048-emmtplv3 219 12 for for IN cord-309048-emmtplv3 219 13 the the DT cord-309048-emmtplv3 219 14 phytopathogenic phytopathogenic JJ cord-309048-emmtplv3 219 15 fungus fungus NN cord-309048-emmtplv3 219 16 , , , cord-309048-emmtplv3 219 17 Colletotrichum Colletotrichum NNP cord-309048-emmtplv3 219 18 acutatum acutatum NNP cord-309048-emmtplv3 219 19 , , , cord-309048-emmtplv3 219 20 incidentally incidentally RB cord-309048-emmtplv3 219 21 demonstrated demonstrate VBD cord-309048-emmtplv3 219 22 efficient efficient JJ cord-309048-emmtplv3 219 23 assembly assembly NN cord-309048-emmtplv3 219 24 of of IN cord-309048-emmtplv3 219 25 particles particle NNS cord-309048-emmtplv3 219 26 within within IN cord-309048-emmtplv3 219 27 the the DT cord-309048-emmtplv3 219 28 hyphal hyphal NN cord-309048-emmtplv3 219 29 cells cell NNS cord-309048-emmtplv3 219 30 ( ( -LRB- cord-309048-emmtplv3 219 31 Mascia Mascia NNP cord-309048-emmtplv3 219 32 et et NNP cord-309048-emmtplv3 219 33 al al NNP cord-309048-emmtplv3 219 34 . . . cord-309048-emmtplv3 220 1 , , , cord-309048-emmtplv3 220 2 2014 2014 CD cord-309048-emmtplv3 220 3 ) ) -RRB- cord-309048-emmtplv3 220 4 . . . cord-309048-emmtplv3 221 1 These these DT cord-309048-emmtplv3 221 2 results result NNS cord-309048-emmtplv3 221 3 suggest suggest VBP cord-309048-emmtplv3 221 4 that that IN cord-309048-emmtplv3 221 5 it -PRON- PRP cord-309048-emmtplv3 221 6 is be VBZ cord-309048-emmtplv3 221 7 likely likely JJ cord-309048-emmtplv3 221 8 that that IN cord-309048-emmtplv3 221 9 assembly assembly NN cord-309048-emmtplv3 221 10 competent competent JJ cord-309048-emmtplv3 221 11 TMV TMV NNP cord-309048-emmtplv3 221 12 CP CP NNP cord-309048-emmtplv3 221 13 can can MD cord-309048-emmtplv3 221 14 be be VB cord-309048-emmtplv3 221 15 generated generate VBN cord-309048-emmtplv3 221 16 in in IN cord-309048-emmtplv3 221 17 most most JJS cord-309048-emmtplv3 221 18 eukaryotic eukaryotic JJ cord-309048-emmtplv3 221 19 expression expression NN cord-309048-emmtplv3 221 20 systems system NNS cord-309048-emmtplv3 221 21 . . . cord-309048-emmtplv3 222 1 Indeed indeed RB cord-309048-emmtplv3 222 2 , , , cord-309048-emmtplv3 222 3 work work VB cord-309048-emmtplv3 222 4 on on IN cord-309048-emmtplv3 222 5 the the DT cord-309048-emmtplv3 222 6 identification identification NN cord-309048-emmtplv3 222 7 of of IN cord-309048-emmtplv3 222 8 the the DT cord-309048-emmtplv3 222 9 TMV TMV NNP cord-309048-emmtplv3 222 10 CP CP NNP cord-309048-emmtplv3 222 11 subgenomic subgenomic NNP cord-309048-emmtplv3 222 12 mRNA mrna NN cord-309048-emmtplv3 222 13 showed show VBD cord-309048-emmtplv3 222 14 that that IN cord-309048-emmtplv3 222 15 CP CP NNP cord-309048-emmtplv3 222 16 produced produce VBN cord-309048-emmtplv3 222 17 via via IN cord-309048-emmtplv3 222 18 in in FW cord-309048-emmtplv3 222 19 vitro vitro FW cord-309048-emmtplv3 222 20 translation translation NN cord-309048-emmtplv3 222 21 in in IN cord-309048-emmtplv3 222 22 wheat wheat NN cord-309048-emmtplv3 222 23 germ germ NN cord-309048-emmtplv3 222 24 extracts extract NNS cord-309048-emmtplv3 222 25 could could MD cord-309048-emmtplv3 222 26 assemble assemble VB cord-309048-emmtplv3 222 27 with with IN cord-309048-emmtplv3 222 28 exogenously exogenously RB cord-309048-emmtplv3 222 29 added add VBN cord-309048-emmtplv3 222 30 TMV TMV NNP cord-309048-emmtplv3 222 31 RNA RNA NNP cord-309048-emmtplv3 222 32 ( ( -LRB- cord-309048-emmtplv3 222 33 Hunter Hunter NNP cord-309048-emmtplv3 222 34 et et NNP cord-309048-emmtplv3 222 35 al al NNP cord-309048-emmtplv3 222 36 . . NNP cord-309048-emmtplv3 222 37 , , , cord-309048-emmtplv3 222 38 1976 1976 CD cord-309048-emmtplv3 222 39 ) ) -RRB- cord-309048-emmtplv3 222 40 . . . cord-309048-emmtplv3 223 1 Following follow VBG cord-309048-emmtplv3 223 2 the the DT cord-309048-emmtplv3 223 3 detailed detailed JJ cord-309048-emmtplv3 223 4 characterization characterization NN cord-309048-emmtplv3 223 5 of of IN cord-309048-emmtplv3 223 6 the the DT cord-309048-emmtplv3 223 7 OAS OAS NNP cord-309048-emmtplv3 223 8 , , , cord-309048-emmtplv3 223 9 it -PRON- PRP cord-309048-emmtplv3 223 10 was be VBD cord-309048-emmtplv3 223 11 shown show VBN cord-309048-emmtplv3 223 12 that that IN cord-309048-emmtplv3 223 13 it -PRON- PRP cord-309048-emmtplv3 223 14 is be VBZ cord-309048-emmtplv3 223 15 possible possible JJ cord-309048-emmtplv3 223 16 to to TO cord-309048-emmtplv3 223 17 efficiently efficiently RB cord-309048-emmtplv3 223 18 encapsidate encapsidate VB cord-309048-emmtplv3 223 19 essentially essentially RB cord-309048-emmtplv3 223 20 any any DT cord-309048-emmtplv3 223 21 RNA RNA NNP cord-309048-emmtplv3 223 22 molecule molecule NN cord-309048-emmtplv3 223 23 provided provide VBN cord-309048-emmtplv3 223 24 it -PRON- PRP cord-309048-emmtplv3 224 1 contains contain VBZ cord-309048-emmtplv3 224 2 the the DT cord-309048-emmtplv3 224 3 OAS OAS NNP cord-309048-emmtplv3 224 4 ( ( -LRB- cord-309048-emmtplv3 225 1 Gallie Gallie NNP cord-309048-emmtplv3 225 2 et et FW cord-309048-emmtplv3 225 3 al al NNP cord-309048-emmtplv3 225 4 . . . cord-309048-emmtplv3 226 1 , , , cord-309048-emmtplv3 226 2 1987b 1987b CD cord-309048-emmtplv3 226 3 ; ; : cord-309048-emmtplv3 226 4 Sleat Sleat NNP cord-309048-emmtplv3 226 5 et et NNP cord-309048-emmtplv3 226 6 al al NNP cord-309048-emmtplv3 226 7 . . NNP cord-309048-emmtplv3 226 8 , , , cord-309048-emmtplv3 226 9 1986 1986 CD cord-309048-emmtplv3 226 10 ; ; : cord-309048-emmtplv3 226 11 Turner Turner NNP cord-309048-emmtplv3 226 12 et et NNP cord-309048-emmtplv3 226 13 al al NNP cord-309048-emmtplv3 226 14 . . NNP cord-309048-emmtplv3 226 15 , , , cord-309048-emmtplv3 226 16 1989 1989 CD cord-309048-emmtplv3 226 17 ) ) -RRB- cord-309048-emmtplv3 226 18 . . . cord-309048-emmtplv3 227 1 The the DT cord-309048-emmtplv3 227 2 initial initial JJ cord-309048-emmtplv3 227 3 experiments experiment NNS cord-309048-emmtplv3 227 4 involved involve VBD cord-309048-emmtplv3 227 5 the the DT cord-309048-emmtplv3 227 6 use use NN cord-309048-emmtplv3 227 7 of of IN cord-309048-emmtplv3 227 8 wild wild JJ cord-309048-emmtplv3 227 9 - - HYPH cord-309048-emmtplv3 227 10 type type NN cord-309048-emmtplv3 227 11 CP cp NN cord-309048-emmtplv3 227 12 purified purify VBN cord-309048-emmtplv3 227 13 from from IN cord-309048-emmtplv3 227 14 TMV TMV NNP cord-309048-emmtplv3 227 15 particles particle NNS cord-309048-emmtplv3 227 16 produced produce VBN cord-309048-emmtplv3 227 17 by by IN cord-309048-emmtplv3 227 18 infection infection NN cord-309048-emmtplv3 227 19 although although IN cord-309048-emmtplv3 227 20 they -PRON- PRP cord-309048-emmtplv3 227 21 also also RB cord-309048-emmtplv3 227 22 demonstrated demonstrate VBD cord-309048-emmtplv3 227 23 that that IN cord-309048-emmtplv3 227 24 RNA RNA NNP cord-309048-emmtplv3 227 25 containing contain VBG cord-309048-emmtplv3 227 26 an an DT cord-309048-emmtplv3 227 27 OAS OAS NNP cord-309048-emmtplv3 227 28 transcribed transcribe VBN cord-309048-emmtplv3 227 29 from from IN cord-309048-emmtplv3 227 30 a a DT cord-309048-emmtplv3 227 31 transgene transgene NN cord-309048-emmtplv3 227 32 could could MD cord-309048-emmtplv3 227 33 assemble assemble VB cord-309048-emmtplv3 227 34 with with IN cord-309048-emmtplv3 227 35 CP CP NNP cord-309048-emmtplv3 227 36 produced produce VBN cord-309048-emmtplv3 227 37 via via IN cord-309048-emmtplv3 227 38 TMV TMV NNP cord-309048-emmtplv3 227 39 infection infection NN cord-309048-emmtplv3 228 1 ( ( -LRB- cord-309048-emmtplv3 228 2 Sleat Sleat NNP cord-309048-emmtplv3 228 3 et et NNP cord-309048-emmtplv3 228 4 al al NNP cord-309048-emmtplv3 228 5 . . NNP cord-309048-emmtplv3 228 6 , , , cord-309048-emmtplv3 228 7 1988 1988 CD cord-309048-emmtplv3 228 8 ) ) -RRB- cord-309048-emmtplv3 228 9 . . . cord-309048-emmtplv3 229 1 Jupin Jupin NNP cord-309048-emmtplv3 229 2 et et FW cord-309048-emmtplv3 229 3 al al NNP cord-309048-emmtplv3 229 4 . . . cord-309048-emmtplv3 230 1 ( ( -LRB- cord-309048-emmtplv3 230 2 1989 1989 CD cord-309048-emmtplv3 230 3 ) ) -RRB- cord-309048-emmtplv3 230 4 proposed propose VBD cord-309048-emmtplv3 230 5 that that IN cord-309048-emmtplv3 230 6 the the DT cord-309048-emmtplv3 230 7 ability ability NN cord-309048-emmtplv3 230 8 to to TO cord-309048-emmtplv3 230 9 package package VB cord-309048-emmtplv3 230 10 transcripts transcript NNS cord-309048-emmtplv3 230 11 containing contain VBG cord-309048-emmtplv3 230 12 the the DT cord-309048-emmtplv3 230 13 OAS OAS NNP cord-309048-emmtplv3 230 14 might may MD cord-309048-emmtplv3 230 15 provide provide VB cord-309048-emmtplv3 230 16 a a DT cord-309048-emmtplv3 230 17 means means NN cord-309048-emmtplv3 230 18 of of IN cord-309048-emmtplv3 230 19 protecting protect VBG cord-309048-emmtplv3 230 20 labile labile JJ cord-309048-emmtplv3 230 21 RNA RNA NNP cord-309048-emmtplv3 230 22 molecules molecule NNS cord-309048-emmtplv3 230 23 during during IN cord-309048-emmtplv3 230 24 shipping shipping NN cord-309048-emmtplv3 230 25 . . . cord-309048-emmtplv3 231 1 A a DT cord-309048-emmtplv3 231 2 similar similar JJ cord-309048-emmtplv3 231 3 protective protective JJ cord-309048-emmtplv3 231 4 role role NN cord-309048-emmtplv3 231 5 of of IN cord-309048-emmtplv3 231 6 the the DT cord-309048-emmtplv3 231 7 CP cp NN cord-309048-emmtplv3 231 8 has have VBZ cord-309048-emmtplv3 231 9 been be VBN cord-309048-emmtplv3 231 10 used use VBN cord-309048-emmtplv3 231 11 in in IN cord-309048-emmtplv3 231 12 the the DT cord-309048-emmtplv3 231 13 development development NN cord-309048-emmtplv3 231 14 of of IN cord-309048-emmtplv3 231 15 positive positive JJ cord-309048-emmtplv3 231 16 controls control NNS cord-309048-emmtplv3 231 17 for for IN cord-309048-emmtplv3 231 18 PCR PCR NNP cord-309048-emmtplv3 231 19 - - HYPH cord-309048-emmtplv3 231 20 based base VBN cord-309048-emmtplv3 231 21 diagnosis diagnosis NN cord-309048-emmtplv3 231 22 of of IN cord-309048-emmtplv3 231 23 Ebola Ebola NNP cord-309048-emmtplv3 231 24 infections infection NNS cord-309048-emmtplv3 232 1 ( ( -LRB- cord-309048-emmtplv3 232 2 Lam Lam NNP cord-309048-emmtplv3 232 3 et et FW cord-309048-emmtplv3 232 4 al al NNP cord-309048-emmtplv3 232 5 . . NNP cord-309048-emmtplv3 232 6 , , , cord-309048-emmtplv3 232 7 2016 2016 CD cord-309048-emmtplv3 232 8 ) ) -RRB- cord-309048-emmtplv3 232 9 . . . cord-309048-emmtplv3 233 1 In in IN cord-309048-emmtplv3 233 2 vitro vitro FW cord-309048-emmtplv3 233 3 assembled assemble VBN cord-309048-emmtplv3 233 4 rods rod NNS cord-309048-emmtplv3 233 5 also also RB cord-309048-emmtplv3 233 6 have have VBP cord-309048-emmtplv3 233 7 been be VBN cord-309048-emmtplv3 233 8 shown show VBN cord-309048-emmtplv3 233 9 to to TO cord-309048-emmtplv3 233 10 be be VB cord-309048-emmtplv3 233 11 an an DT cord-309048-emmtplv3 233 12 effective effective JJ cord-309048-emmtplv3 233 13 method method NN cord-309048-emmtplv3 233 14 of of IN cord-309048-emmtplv3 233 15 delivering deliver VBG cord-309048-emmtplv3 233 16 specific specific JJ cord-309048-emmtplv3 233 17 transcripts transcript NNS cord-309048-emmtplv3 233 18 since since IN cord-309048-emmtplv3 233 19 they -PRON- PRP cord-309048-emmtplv3 233 20 uncoat uncoat VBP cord-309048-emmtplv3 233 21 to to TO cord-309048-emmtplv3 233 22 allow allow VB cord-309048-emmtplv3 233 23 translation translation NN cord-309048-emmtplv3 233 24 of of IN cord-309048-emmtplv3 233 25 incorporated incorporate VBN cord-309048-emmtplv3 233 26 RNA RNA NNP cord-309048-emmtplv3 233 27 within within IN cord-309048-emmtplv3 233 28 target target NN cord-309048-emmtplv3 233 29 cells cell NNS cord-309048-emmtplv3 233 30 ( ( -LRB- cord-309048-emmtplv3 233 31 Gallie Gallie NNP cord-309048-emmtplv3 233 32 et et FW cord-309048-emmtplv3 233 33 al al NNP cord-309048-emmtplv3 233 34 . . NNP cord-309048-emmtplv3 233 35 , , , cord-309048-emmtplv3 233 36 1987b 1987b CD cord-309048-emmtplv3 233 37 ) ) -RRB- cord-309048-emmtplv3 233 38 . . . cord-309048-emmtplv3 234 1 Smith Smith NNP cord-309048-emmtplv3 234 2 et et NNP cord-309048-emmtplv3 234 3 al al NNP cord-309048-emmtplv3 234 4 . . . cord-309048-emmtplv3 235 1 ( ( -LRB- cord-309048-emmtplv3 235 2 2007 2007 CD cord-309048-emmtplv3 235 3 ) ) -RRB- cord-309048-emmtplv3 235 4 made make VBD cord-309048-emmtplv3 235 5 use use NN cord-309048-emmtplv3 235 6 of of IN cord-309048-emmtplv3 235 7 this this DT cord-309048-emmtplv3 235 8 phenomenon phenomenon NN cord-309048-emmtplv3 235 9 to to TO cord-309048-emmtplv3 235 10 deliver deliver VB cord-309048-emmtplv3 235 11 RNA RNA NNP cord-309048-emmtplv3 235 12 encoding encode VBG cord-309048-emmtplv3 235 13 the the DT cord-309048-emmtplv3 235 14 nonstructural nonstructural JJ cord-309048-emmtplv3 235 15 proteins protein NNS cord-309048-emmtplv3 235 16 from from IN cord-309048-emmtplv3 235 17 Semliki Semliki NNP cord-309048-emmtplv3 235 18 forest forest NN cord-309048-emmtplv3 235 19 virus virus NN cord-309048-emmtplv3 235 20 into into IN cord-309048-emmtplv3 235 21 mammalian mammalian JJ cord-309048-emmtplv3 235 22 cells cell NNS cord-309048-emmtplv3 235 23 . . . cord-309048-emmtplv3 236 1 They -PRON- PRP cord-309048-emmtplv3 236 2 showed show VBD cord-309048-emmtplv3 236 3 that that IN cord-309048-emmtplv3 236 4 the the DT cord-309048-emmtplv3 236 5 encapsidated encapsidate VBN cord-309048-emmtplv3 236 6 RNA RNA NNP cord-309048-emmtplv3 236 7 was be VBD cord-309048-emmtplv3 236 8 uncoated uncoate VBN cord-309048-emmtplv3 236 9 and and CC cord-309048-emmtplv3 236 10 translated translate VBN cord-309048-emmtplv3 236 11 within within IN cord-309048-emmtplv3 236 12 the the DT cord-309048-emmtplv3 236 13 cells cell NNS cord-309048-emmtplv3 236 14 , , , cord-309048-emmtplv3 236 15 and and CC cord-309048-emmtplv3 236 16 that that IN cord-309048-emmtplv3 236 17 the the DT cord-309048-emmtplv3 236 18 expressed express VBN cord-309048-emmtplv3 236 19 protein protein NN cord-309048-emmtplv3 236 20 stimulated stimulate VBD cord-309048-emmtplv3 236 21 an an DT cord-309048-emmtplv3 236 22 immune immune JJ cord-309048-emmtplv3 236 23 response response NN cord-309048-emmtplv3 236 24 in in IN cord-309048-emmtplv3 236 25 mice mouse NNS cord-309048-emmtplv3 236 26 . . . cord-309048-emmtplv3 237 1 While while IN cord-309048-emmtplv3 237 2 natural natural JJ cord-309048-emmtplv3 237 3 TMV TMV NNP cord-309048-emmtplv3 237 4 RNA RNA NNP cord-309048-emmtplv3 237 5 has have VBZ cord-309048-emmtplv3 237 6 only only RB cord-309048-emmtplv3 237 7 a a DT cord-309048-emmtplv3 237 8 single single JJ cord-309048-emmtplv3 237 9 copy copy NN cord-309048-emmtplv3 237 10 of of IN cord-309048-emmtplv3 237 11 the the DT cord-309048-emmtplv3 237 12 OAS OAS NNP cord-309048-emmtplv3 237 13 resulting result VBG cord-309048-emmtplv3 237 14 in in IN cord-309048-emmtplv3 237 15 the the DT cord-309048-emmtplv3 237 16 production production NN cord-309048-emmtplv3 237 17 of of IN cord-309048-emmtplv3 237 18 linear linear JJ cord-309048-emmtplv3 237 19 particles particle NNS cord-309048-emmtplv3 237 20 , , , cord-309048-emmtplv3 237 21 it -PRON- PRP cord-309048-emmtplv3 237 22 is be VBZ cord-309048-emmtplv3 237 23 possible possible JJ cord-309048-emmtplv3 237 24 to to TO cord-309048-emmtplv3 237 25 generate generate VB cord-309048-emmtplv3 237 26 more more JJR cord-309048-emmtplv3 237 27 complex complex JJ cord-309048-emmtplv3 237 28 structures structure NNS cord-309048-emmtplv3 237 29 through through IN cord-309048-emmtplv3 237 30 the the DT cord-309048-emmtplv3 237 31 incorporation incorporation NN cord-309048-emmtplv3 237 32 of of IN cord-309048-emmtplv3 237 33 more more JJR cord-309048-emmtplv3 237 34 than than IN cord-309048-emmtplv3 237 35 one one CD cord-309048-emmtplv3 237 36 OAS OAS NNP cord-309048-emmtplv3 237 37 on on IN cord-309048-emmtplv3 237 38 the the DT cord-309048-emmtplv3 237 39 same same JJ cord-309048-emmtplv3 237 40 transcript transcript NN cord-309048-emmtplv3 237 41 ( ( -LRB- cord-309048-emmtplv3 237 42 Gallie Gallie NNP cord-309048-emmtplv3 237 43 et et FW cord-309048-emmtplv3 237 44 al al NNP cord-309048-emmtplv3 237 45 . . NNP cord-309048-emmtplv3 237 46 , , , cord-309048-emmtplv3 237 47 1987c 1987c CD cord-309048-emmtplv3 237 48 ; ; : cord-309048-emmtplv3 237 49 Fig fig NN cord-309048-emmtplv3 237 50 . . . cord-309048-emmtplv3 237 51 3 3 CD cord-309048-emmtplv3 237 52 ) ) -RRB- cord-309048-emmtplv3 237 53 . . . cord-309048-emmtplv3 238 1 Systematic systematic JJ cord-309048-emmtplv3 238 2 studies study NNS cord-309048-emmtplv3 238 3 have have VBP cord-309048-emmtplv3 238 4 shown show VBN cord-309048-emmtplv3 238 5 that that IN cord-309048-emmtplv3 238 6 the the DT cord-309048-emmtplv3 238 7 incorporation incorporation NN cord-309048-emmtplv3 238 8 of of IN cord-309048-emmtplv3 238 9 multiple multiple JJ cord-309048-emmtplv3 238 10 OAS OAS NNP cord-309048-emmtplv3 238 11 sequences sequence NNS cord-309048-emmtplv3 238 12 can can MD cord-309048-emmtplv3 238 13 generate generate VB cord-309048-emmtplv3 238 14 TMV TMV NNP cord-309048-emmtplv3 238 15 - - HYPH cord-309048-emmtplv3 238 16 based base VBN cord-309048-emmtplv3 238 17 rods rod NNS cord-309048-emmtplv3 238 18 with with IN cord-309048-emmtplv3 238 19 a a DT cord-309048-emmtplv3 238 20 number number NN cord-309048-emmtplv3 238 21 of of IN cord-309048-emmtplv3 238 22 different different JJ cord-309048-emmtplv3 238 23 morphologies morphology NNS cord-309048-emmtplv3 238 24 including include VBG cord-309048-emmtplv3 238 25 kinked kinked JJ cord-309048-emmtplv3 238 26 " " `` cord-309048-emmtplv3 238 27 nanoboomerangs nanoboomerang NNS cord-309048-emmtplv3 238 28 " " '' cord-309048-emmtplv3 238 29 as as RB cord-309048-emmtplv3 238 30 well well RB cord-309048-emmtplv3 238 31 as as IN cord-309048-emmtplv3 238 32 tri tri JJ cord-309048-emmtplv3 238 33 - - JJ cord-309048-emmtplv3 238 34 and and CC cord-309048-emmtplv3 238 35 tetrapod tetrapod JJ cord-309048-emmtplv3 238 36 structures structure NNS cord-309048-emmtplv3 238 37 Fig Fig NNP cord-309048-emmtplv3 238 38 . . . cord-309048-emmtplv3 238 39 3 3 CD cord-309048-emmtplv3 238 40 ) ) -RRB- cord-309048-emmtplv3 238 41 . . . cord-309048-emmtplv3 239 1 The the DT cord-309048-emmtplv3 239 2 applications application NNS cord-309048-emmtplv3 239 3 of of IN cord-309048-emmtplv3 239 4 such such JJ cord-309048-emmtplv3 239 5 variants variant NNS cord-309048-emmtplv3 239 6 are be VBP cord-309048-emmtplv3 239 7 described describe VBN cord-309048-emmtplv3 239 8 in in IN cord-309048-emmtplv3 239 9 Section section NN cord-309048-emmtplv3 239 10 6 6 CD cord-309048-emmtplv3 239 11 . . . cord-309048-emmtplv3 240 1 TMV TMV NNP cord-309048-emmtplv3 240 2 and and CC cord-309048-emmtplv3 240 3 TMV TMV NNP cord-309048-emmtplv3 240 4 - - HYPH cord-309048-emmtplv3 240 5 like like JJ cord-309048-emmtplv3 240 6 particles particle NNS cord-309048-emmtplv3 240 7 have have VBP cord-309048-emmtplv3 240 8 been be VBN cord-309048-emmtplv3 240 9 coupled couple VBN cord-309048-emmtplv3 240 10 to to IN cord-309048-emmtplv3 240 11 a a DT cord-309048-emmtplv3 240 12 number number NN cord-309048-emmtplv3 240 13 of of IN cord-309048-emmtplv3 240 14 organic organic JJ cord-309048-emmtplv3 240 15 molecules molecule NNS cord-309048-emmtplv3 240 16 , , , cord-309048-emmtplv3 240 17 including include VBG cord-309048-emmtplv3 240 18 chromophores chromophore NNS cord-309048-emmtplv3 240 19 , , , cord-309048-emmtplv3 240 20 polymers polymer NNS cord-309048-emmtplv3 240 21 , , , cord-309048-emmtplv3 240 22 or or CC cord-309048-emmtplv3 240 23 certain certain JJ cord-309048-emmtplv3 240 24 heavy heavy JJ cord-309048-emmtplv3 240 25 metal metal NN cord-309048-emmtplv3 240 26 complexes complex NNS cord-309048-emmtplv3 240 27 , , , cord-309048-emmtplv3 240 28 to to TO cord-309048-emmtplv3 240 29 create create VB cord-309048-emmtplv3 240 30 classes class NNS cord-309048-emmtplv3 240 31 of of IN cord-309048-emmtplv3 240 32 TMV TMV NNP cord-309048-emmtplv3 240 33 - - HYPH cord-309048-emmtplv3 240 34 derived derive VBN cord-309048-emmtplv3 240 35 effector effector NN cord-309048-emmtplv3 240 36 colloids colloid NNS cord-309048-emmtplv3 240 37 . . . cord-309048-emmtplv3 241 1 Such such JJ cord-309048-emmtplv3 241 2 hybrid hybrid JJ cord-309048-emmtplv3 241 3 objects object NNS cord-309048-emmtplv3 241 4 are be VBP cord-309048-emmtplv3 241 5 envisaged envisage VBN cord-309048-emmtplv3 241 6 for for IN cord-309048-emmtplv3 241 7 biomedical biomedical JJ cord-309048-emmtplv3 241 8 applications application NNS cord-309048-emmtplv3 241 9 inside inside IN cord-309048-emmtplv3 241 10 living live VBG cord-309048-emmtplv3 241 11 organisms organism NNS cord-309048-emmtplv3 241 12 . . . cord-309048-emmtplv3 242 1 As as IN cord-309048-emmtplv3 242 2 such such JJ cord-309048-emmtplv3 242 3 applications application NNS cord-309048-emmtplv3 242 4 are be VBP cord-309048-emmtplv3 242 5 many many JJ cord-309048-emmtplv3 242 6 and and CC cord-309048-emmtplv3 242 7 varied varied JJ cord-309048-emmtplv3 242 8 , , , cord-309048-emmtplv3 242 9 this this DT cord-309048-emmtplv3 242 10 section section NN cord-309048-emmtplv3 242 11 is be VBZ cord-309048-emmtplv3 242 12 intended intend VBN cord-309048-emmtplv3 242 13 more more JJR cord-309048-emmtplv3 242 14 to to TO cord-309048-emmtplv3 242 15 indicate indicate VB cord-309048-emmtplv3 242 16 the the DT cord-309048-emmtplv3 242 17 possible possible JJ cord-309048-emmtplv3 242 18 range range NN cord-309048-emmtplv3 242 19 of of IN cord-309048-emmtplv3 242 20 applications application NNS cord-309048-emmtplv3 242 21 rather rather RB cord-309048-emmtplv3 242 22 than than IN cord-309048-emmtplv3 242 23 to to TO cord-309048-emmtplv3 242 24 provide provide VB cord-309048-emmtplv3 242 25 a a DT cord-309048-emmtplv3 242 26 comprehensive comprehensive JJ cord-309048-emmtplv3 242 27 account account NN cord-309048-emmtplv3 242 28 . . . cord-309048-emmtplv3 243 1 For for IN cord-309048-emmtplv3 243 2 those those DT cord-309048-emmtplv3 243 3 readers reader NNS cord-309048-emmtplv3 243 4 interested interested JJ cord-309048-emmtplv3 243 5 in in IN cord-309048-emmtplv3 243 6 this this DT cord-309048-emmtplv3 243 7 aspect aspect NN cord-309048-emmtplv3 243 8 , , , cord-309048-emmtplv3 243 9 there there EX cord-309048-emmtplv3 243 10 are be VBP cord-309048-emmtplv3 243 11 several several JJ cord-309048-emmtplv3 243 12 excellent excellent JJ cord-309048-emmtplv3 243 13 recent recent JJ cord-309048-emmtplv3 243 14 reviews review NNS cord-309048-emmtplv3 243 15 ( ( -LRB- cord-309048-emmtplv3 243 16 e.g. e.g. RB cord-309048-emmtplv3 243 17 , , , cord-309048-emmtplv3 243 18 Koch Koch NNP cord-309048-emmtplv3 243 19 et et NNP cord-309048-emmtplv3 243 20 al al NNP cord-309048-emmtplv3 243 21 . . NNP cord-309048-emmtplv3 243 22 , , , cord-309048-emmtplv3 243 23 2016 2016 CD cord-309048-emmtplv3 243 24 ; ; : cord-309048-emmtplv3 243 25 Wen Wen NNP cord-309048-emmtplv3 243 26 and and CC cord-309048-emmtplv3 243 27 Steinmetz Steinmetz NNP cord-309048-emmtplv3 243 28 , , , cord-309048-emmtplv3 243 29 2016 2016 CD cord-309048-emmtplv3 243 30 ) ) -RRB- cord-309048-emmtplv3 243 31 . . . cord-309048-emmtplv3 244 1 branched branch VBN cord-309048-emmtplv3 244 2 boomerang boomerang NN cord-309048-emmtplv3 244 3 up up IN cord-309048-emmtplv3 244 4 to to IN cord-309048-emmtplv3 244 5 tetrapod tetrapod JJ cord-309048-emmtplv3 244 6 products product NNS cord-309048-emmtplv3 244 7 accessed access VBN cord-309048-emmtplv3 244 8 through through IN cord-309048-emmtplv3 244 9 colliding collide VBG cord-309048-emmtplv3 244 10 nanotube nanotube NN cord-309048-emmtplv3 244 11 domain domain NN cord-309048-emmtplv3 244 12 ends end VBZ cord-309048-emmtplv3 244 13 growing grow VBG cord-309048-emmtplv3 244 14 on on IN cord-309048-emmtplv3 244 15 RNA RNA NNP cord-309048-emmtplv3 244 16 scaffolds scaffold NNS cord-309048-emmtplv3 244 17 with with IN cord-309048-emmtplv3 244 18 two two CD cord-309048-emmtplv3 244 19 up up IN cord-309048-emmtplv3 244 20 to to IN cord-309048-emmtplv3 244 21 five five CD cord-309048-emmtplv3 244 22 OAS OAS NNP cord-309048-emmtplv3 244 23 . . . cord-309048-emmtplv3 245 1 ( ( -LRB- cord-309048-emmtplv3 245 2 C C NNP cord-309048-emmtplv3 245 3 ) ) -RRB- cord-309048-emmtplv3 245 4 TMV TMV NNP cord-309048-emmtplv3 245 5 - - HYPH cord-309048-emmtplv3 245 6 like like JJ cord-309048-emmtplv3 245 7 nanorods nanorods NNP cord-309048-emmtplv3 245 8 with with IN cord-309048-emmtplv3 245 9 selectively selectively RB cord-309048-emmtplv3 245 10 addressable addressable JJ cord-309048-emmtplv3 245 11 longitudinal longitudinal JJ cord-309048-emmtplv3 245 12 subdomains subdomain NNS cord-309048-emmtplv3 245 13 , , , cord-309048-emmtplv3 245 14 obtained obtain VBN cord-309048-emmtplv3 245 15 either either CC cord-309048-emmtplv3 245 16 by by IN cord-309048-emmtplv3 245 17 serial serial JJ cord-309048-emmtplv3 245 18 assembly assembly NN cord-309048-emmtplv3 245 19 with with IN cord-309048-emmtplv3 245 20 limited limited JJ cord-309048-emmtplv3 245 21 amounts amount NNS cord-309048-emmtplv3 245 22 of of IN cord-309048-emmtplv3 245 23 distinct distinct JJ cord-309048-emmtplv3 245 24 CP cp NN cord-309048-emmtplv3 245 25 species specie NNS cord-309048-emmtplv3 245 26 or or CC cord-309048-emmtplv3 245 27 in in IN cord-309048-emmtplv3 245 28 a a DT cord-309048-emmtplv3 245 29 nanometrically nanometrically RB cord-309048-emmtplv3 245 30 defined define VBN cord-309048-emmtplv3 245 31 manner manner NN cord-309048-emmtplv3 245 32 by by IN cord-309048-emmtplv3 245 33 a a DT cord-309048-emmtplv3 245 34 DNA dna NN cord-309048-emmtplv3 245 35 blocking block VBG cord-309048-emmtplv3 245 36 element element NN cord-309048-emmtplv3 245 37 - - HYPH cord-309048-emmtplv3 245 38 enabled enable VBN cord-309048-emmtplv3 245 39 stop stop VB cord-309048-emmtplv3 245 40 - - HYPH cord-309048-emmtplv3 245 41 and and CC cord-309048-emmtplv3 245 42 - - HYPH cord-309048-emmtplv3 245 43 go go NN cord-309048-emmtplv3 245 44 procedure procedure NN cord-309048-emmtplv3 245 45 . . . cord-309048-emmtplv3 246 1 Bottom bottom JJ cord-309048-emmtplv3 246 2 row row NN cord-309048-emmtplv3 246 3 : : : cord-309048-emmtplv3 247 1 Hybrid hybrid JJ cord-309048-emmtplv3 247 2 assemblies assembly NNS cord-309048-emmtplv3 247 3 with with IN cord-309048-emmtplv3 247 4 nonbiomolecular nonbiomolecular NNP cord-309048-emmtplv3 247 5 core core NN cord-309048-emmtplv3 247 6 structures structure NNS cord-309048-emmtplv3 247 7 : : : cord-309048-emmtplv3 247 8 ( ( -LRB- cord-309048-emmtplv3 247 9 D D NNP cord-309048-emmtplv3 247 10 ) ) -RRB- cord-309048-emmtplv3 247 11 nanostars nanostar NNS cord-309048-emmtplv3 247 12 with with IN cord-309048-emmtplv3 247 13 TMV TMV NNP cord-309048-emmtplv3 247 14 - - HYPH cord-309048-emmtplv3 247 15 deduced deduce VBN cord-309048-emmtplv3 247 16 arms arm NNS cord-309048-emmtplv3 247 17 , , , cord-309048-emmtplv3 247 18 grown grow VBN cord-309048-emmtplv3 247 19 by by IN cord-309048-emmtplv3 247 20 bottom bottom NN cord-309048-emmtplv3 247 21 - - HYPH cord-309048-emmtplv3 247 22 up up NN cord-309048-emmtplv3 247 23 technology technology NN cord-309048-emmtplv3 247 24 on on IN cord-309048-emmtplv3 247 25 DNA dna NN cord-309048-emmtplv3 247 26 - - HYPH cord-309048-emmtplv3 247 27 programmed program VBN cord-309048-emmtplv3 247 28 gold gold NN cord-309048-emmtplv3 247 29 beads bead NNS cord-309048-emmtplv3 247 30 . . . cord-309048-emmtplv3 248 1 ( ( -LRB- cord-309048-emmtplv3 248 2 E e NN cord-309048-emmtplv3 248 3 1 1 CD cord-309048-emmtplv3 248 4 -E -e SYM cord-309048-emmtplv3 248 5 4 4 CD cord-309048-emmtplv3 248 6 ) ) -RRB- cord-309048-emmtplv3 248 7 Expanded expand VBN cord-309048-emmtplv3 248 8 nanoarchitectures nanoarchitecture NNS cord-309048-emmtplv3 248 9 with with IN cord-309048-emmtplv3 248 10 up up IN cord-309048-emmtplv3 248 11 to to TO cord-309048-emmtplv3 248 12 four four CD cord-309048-emmtplv3 248 13 TMV TMV NNP cord-309048-emmtplv3 248 14 arms arm NNS cord-309048-emmtplv3 248 15 linked link VBN cord-309048-emmtplv3 248 16 covalently covalently RB cord-309048-emmtplv3 248 17 to to IN cord-309048-emmtplv3 248 18 tetrahedral tetrahedral JJ cord-309048-emmtplv3 248 19 adamantane adamantane NNS cord-309048-emmtplv3 248 20 - - HYPH cord-309048-emmtplv3 248 21 based base VBN cord-309048-emmtplv3 248 22 organic organic JJ cord-309048-emmtplv3 248 23 cores core NNS cord-309048-emmtplv3 248 24 . . . cord-309048-emmtplv3 249 1 Panel Panel NNP cord-309048-emmtplv3 249 2 ( ( -LRB- cord-309048-emmtplv3 249 3 A a NN cord-309048-emmtplv3 249 4 ) ) -RRB- cord-309048-emmtplv3 249 5 reproduced reproduce VBN cord-309048-emmtplv3 249 6 according accord VBG cord-309048-emmtplv3 249 7 to to IN cord-309048-emmtplv3 249 8 the the DT cord-309048-emmtplv3 249 9 copyright copyright NN cord-309048-emmtplv3 249 10 terms term NNS cord-309048-emmtplv3 249 11 from from IN cord-309048-emmtplv3 249 12 Altintoprak Altintoprak NNPS cord-309048-emmtplv3 249 13 , , , cord-309048-emmtplv3 249 14 K. K. NNP cord-309048-emmtplv3 249 15 , , , cord-309048-emmtplv3 249 16 Seidenst€ Seidenst€ NNP cord-309048-emmtplv3 249 17 ucker ucker NN cord-309048-emmtplv3 249 18 , , , cord-309048-emmtplv3 249 19 A. A. NNP cord-309048-emmtplv3 249 20 , , , cord-309048-emmtplv3 249 21 Krolla Krolla NNP cord-309048-emmtplv3 249 22 - - HYPH cord-309048-emmtplv3 249 23 Sidenstein Sidenstein NNP cord-309048-emmtplv3 249 24 , , , cord-309048-emmtplv3 249 25 P. P. NNP cord-309048-emmtplv3 249 26 , , , cord-309048-emmtplv3 249 27 Plettl Plettl NNP cord-309048-emmtplv3 249 28 , , , cord-309048-emmtplv3 249 29 A. A. NNP cord-309048-emmtplv3 249 30 , , , cord-309048-emmtplv3 249 31 Jeske Jeske NNP cord-309048-emmtplv3 249 32 , , , cord-309048-emmtplv3 249 33 H. H. NNP cord-309048-emmtplv3 249 34 , , , cord-309048-emmtplv3 249 35 Gliemann Gliemann NNP cord-309048-emmtplv3 249 36 , , , cord-309048-emmtplv3 249 37 H. H. NNP cord-309048-emmtplv3 249 38 , , , cord-309048-emmtplv3 249 39 Wege Wege NNP cord-309048-emmtplv3 249 40 , , , cord-309048-emmtplv3 249 41 C. C. NNP cord-309048-emmtplv3 249 42 , , , cord-309048-emmtplv3 249 43 2017 2017 CD cord-309048-emmtplv3 249 44 . . . cord-309048-emmtplv3 250 1 RNA RNA NNP cord-309048-emmtplv3 250 2 - - HYPH cord-309048-emmtplv3 250 3 stabilized stabilize VBN cord-309048-emmtplv3 250 4 protein protein NN cord-309048-emmtplv3 250 5 nanorings nanoring NNS cord-309048-emmtplv3 250 6 : : : cord-309048-emmtplv3 250 7 high high JJ cord-309048-emmtplv3 250 8 - - HYPH cord-309048-emmtplv3 250 9 precision precision NN cord-309048-emmtplv3 250 10 adapters adapter NNS cord-309048-emmtplv3 250 11 for for IN cord-309048-emmtplv3 250 12 biohybrid biohybrid NNP cord-309048-emmtplv3 250 13 design design NN cord-309048-emmtplv3 250 14 . . . cord-309048-emmtplv3 251 1 Bioinspired Bioinspired NNP cord-309048-emmtplv3 251 2 Biomimetic Biomimetic NNP cord-309048-emmtplv3 251 3 Nanobiomater Nanobiomater NNP cord-309048-emmtplv3 251 4 . . . cord-309048-emmtplv3 251 5 6 6 CD cord-309048-emmtplv3 251 6 , , , cord-309048-emmtplv3 251 7 208 208 CD cord-309048-emmtplv3 251 8 ; ; : cord-309048-emmtplv3 251 9 panel panel NN cord-309048-emmtplv3 251 10 ( ( -LRB- cord-309048-emmtplv3 251 11 B b NN cord-309048-emmtplv3 251 12 ) ) -RRB- cord-309048-emmtplv3 251 13 reproduced reproduce VBN cord-309048-emmtplv3 251 14 according accord VBG cord-309048-emmtplv3 251 15 to to IN cord-309048-emmtplv3 251 16 the the DT cord-309048-emmtplv3 251 17 copyright copyright NN cord-309048-emmtplv3 251 18 permission permission NN cord-309048-emmtplv3 251 19 terms term NNS cord-309048-emmtplv3 251 20 in in IN cord-309048-emmtplv3 251 21 modified modify VBN cord-309048-emmtplv3 251 22 arrangements arrangement NNS cord-309048-emmtplv3 251 23 from from IN cord-309048-emmtplv3 251 24 Eber Eber NNP cord-309048-emmtplv3 251 25 , , , cord-309048-emmtplv3 251 26 F.J. F.J. NNP cord-309048-emmtplv3 251 27 , , , cord-309048-emmtplv3 251 28 Eiben Eiben NNP cord-309048-emmtplv3 251 29 , , , cord-309048-emmtplv3 251 30 S. S. NNP cord-309048-emmtplv3 251 31 , , , cord-309048-emmtplv3 251 32 Jeske Jeske NNP cord-309048-emmtplv3 251 33 , , , cord-309048-emmtplv3 251 34 H. H. NNP cord-309048-emmtplv3 251 35 , , , cord-309048-emmtplv3 251 36 Wege Wege NNP cord-309048-emmtplv3 251 37 , , , cord-309048-emmtplv3 251 38 C. C. NNP cord-309048-emmtplv3 251 39 , , , cord-309048-emmtplv3 251 40 2015 2015 CD cord-309048-emmtplv3 251 41 . . . cord-309048-emmtplv3 252 1 RNA RNA NNP cord-309048-emmtplv3 252 2 - - HYPH cord-309048-emmtplv3 252 3 controlled control VBN cord-309048-emmtplv3 252 4 assembly assembly NN cord-309048-emmtplv3 252 5 of of IN cord-309048-emmtplv3 252 6 tobacco tobacco NN cord-309048-emmtplv3 252 7 mosaic mosaic NNP cord-309048-emmtplv3 252 8 virus virus NN cord-309048-emmtplv3 252 9 - - HYPH cord-309048-emmtplv3 252 10 derived derive VBN cord-309048-emmtplv3 252 11 complex complex JJ cord-309048-emmtplv3 252 12 structures structure NNS cord-309048-emmtplv3 252 13 : : : cord-309048-emmtplv3 252 14 from from IN cord-309048-emmtplv3 252 15 nanoboomerangs nanoboomerang NNS cord-309048-emmtplv3 252 16 to to IN cord-309048-emmtplv3 252 17 tetrapods tetrapod NNS cord-309048-emmtplv3 252 18 . . . cord-309048-emmtplv3 253 1 Nanoscale Nanoscale NNP cord-309048-emmtplv3 253 2 7 7 CD cord-309048-emmtplv3 253 3 , , , cord-309048-emmtplv3 253 4 344 344 CD cord-309048-emmtplv3 253 5 ; ; : cord-309048-emmtplv3 253 6 panel panel NN cord-309048-emmtplv3 253 7 ( ( -LRB- cord-309048-emmtplv3 253 8 C C NNP cord-309048-emmtplv3 253 9 ) ) -RRB- cord-309048-emmtplv3 253 10 left leave VBD cord-309048-emmtplv3 253 11 : : : cord-309048-emmtplv3 253 12 reproduced reproduce VBN cord-309048-emmtplv3 253 13 from from IN cord-309048-emmtplv3 253 14 Geiger Geiger NNP cord-309048-emmtplv3 253 15 , , , cord-309048-emmtplv3 253 16 F.C. F.C. NNP cord-309048-emmtplv3 253 17 , , , cord-309048-emmtplv3 253 18 Eber Eber NNP cord-309048-emmtplv3 253 19 , , , cord-309048-emmtplv3 253 20 F.J. F.J. NNP cord-309048-emmtplv3 253 21 , , , cord-309048-emmtplv3 253 22 Eiben Eiben NNP cord-309048-emmtplv3 253 23 , , , cord-309048-emmtplv3 253 24 S. S. NNP cord-309048-emmtplv3 253 25 , , , cord-309048-emmtplv3 253 26 Mueller Mueller NNP cord-309048-emmtplv3 253 27 , , , cord-309048-emmtplv3 253 28 A. a. NN cord-309048-emmtplv3 253 29 , , , cord-309048-emmtplv3 253 30 Jeske Jeske NNP cord-309048-emmtplv3 253 31 , , , cord-309048-emmtplv3 253 32 H. H. NNP cord-309048-emmtplv3 253 33 , , , cord-309048-emmtplv3 253 34 Spatz Spatz NNP cord-309048-emmtplv3 253 35 , , , cord-309048-emmtplv3 253 36 J.P. J.P. NNP cord-309048-emmtplv3 253 37 , , , cord-309048-emmtplv3 253 38 Wege Wege NNP cord-309048-emmtplv3 253 39 , , , cord-309048-emmtplv3 253 40 C. C. NNP cord-309048-emmtplv3 253 41 , , , cord-309048-emmtplv3 253 42 2013 2013 CD cord-309048-emmtplv3 253 43 . . . cord-309048-emmtplv3 254 1 TMV TMV NNP cord-309048-emmtplv3 254 2 nanorods nanorods NNP cord-309048-emmtplv3 254 3 with with IN cord-309048-emmtplv3 254 4 programmed program VBN cord-309048-emmtplv3 254 5 longitudinal longitudinal JJ cord-309048-emmtplv3 254 6 domains domain NNS cord-309048-emmtplv3 254 7 of of IN cord-309048-emmtplv3 254 8 differently differently RB cord-309048-emmtplv3 254 9 addressable addressable JJ cord-309048-emmtplv3 254 10 coat coat NN cord-309048-emmtplv3 254 11 proteins protein NNS cord-309048-emmtplv3 254 12 . . . cord-309048-emmtplv3 255 1 Nanoscale nanoscale NN cord-309048-emmtplv3 255 2 5 5 CD cord-309048-emmtplv3 255 3 , , , cord-309048-emmtplv3 255 4 3803 3803 CD cord-309048-emmtplv3 255 5 ; ; : cord-309048-emmtplv3 255 6 scheme scheme NN cord-309048-emmtplv3 255 7 and and CC cord-309048-emmtplv3 255 8 right right NN cord-309048-emmtplv3 255 9 : : : cord-309048-emmtplv3 255 10 reproduced reproduce VBN cord-309048-emmtplv3 255 11 from from IN cord-309048-emmtplv3 255 12 Schneider Schneider NNP cord-309048-emmtplv3 255 13 , , , cord-309048-emmtplv3 255 14 A. a. NN cord-309048-emmtplv3 255 15 , , , cord-309048-emmtplv3 255 16 Eber Eber NNP cord-309048-emmtplv3 255 17 , , , cord-309048-emmtplv3 255 18 F.J. F.J. NNP cord-309048-emmtplv3 255 19 , , , cord-309048-emmtplv3 255 20 Wenz Wenz NNP cord-309048-emmtplv3 255 21 , , , cord-309048-emmtplv3 255 22 N. N. NNP cord-309048-emmtplv3 255 23 , , , cord-309048-emmtplv3 255 24 Altintoprak Altintoprak NNP cord-309048-emmtplv3 255 25 , , , cord-309048-emmtplv3 255 26 K. K. NNP cord-309048-emmtplv3 255 27 , , , cord-309048-emmtplv3 255 28 Jeske Jeske NNP cord-309048-emmtplv3 255 29 , , , cord-309048-emmtplv3 255 30 H. H. NNP cord-309048-emmtplv3 255 31 , , , cord-309048-emmtplv3 255 32 Eiben Eiben NNP cord-309048-emmtplv3 255 33 , , , cord-309048-emmtplv3 255 34 S. S. NNP cord-309048-emmtplv3 255 35 , , , cord-309048-emmtplv3 255 36 Wege Wege NNP cord-309048-emmtplv3 255 37 , , , cord-309048-emmtplv3 255 38 C. C. NNP cord-309048-emmtplv3 255 39 , , , cord-309048-emmtplv3 255 40 2016 2016 CD cord-309048-emmtplv3 255 41 . . . cord-309048-emmtplv3 256 1 Dynamic dynamic JJ cord-309048-emmtplv3 256 2 DNA dna NN cord-309048-emmtplv3 256 3 - - HYPH cord-309048-emmtplv3 256 4 controlled control VBN cord-309048-emmtplv3 256 5 " " `` cord-309048-emmtplv3 256 6 stop stop NN cord-309048-emmtplv3 256 7 - - HYPH cord-309048-emmtplv3 256 8 and- and- NN cord-309048-emmtplv3 256 9 go go VB cord-309048-emmtplv3 256 10 " " '' cord-309048-emmtplv3 256 11 assembly assembly NN cord-309048-emmtplv3 256 12 of of IN cord-309048-emmtplv3 256 13 well well RB cord-309048-emmtplv3 256 14 - - HYPH cord-309048-emmtplv3 256 15 defined define VBN cord-309048-emmtplv3 256 16 protein protein NN cord-309048-emmtplv3 256 17 domains domain NNS cord-309048-emmtplv3 256 18 on on IN cord-309048-emmtplv3 256 19 RNA RNA NNP cord-309048-emmtplv3 256 20 - - HYPH cord-309048-emmtplv3 256 21 scaffolded scaffold VBN cord-309048-emmtplv3 256 22 TMV TMV NNP cord-309048-emmtplv3 256 23 - - HYPH cord-309048-emmtplv3 256 24 like like JJ cord-309048-emmtplv3 256 25 nanotubes nanotube NNS cord-309048-emmtplv3 256 26 . . . cord-309048-emmtplv3 257 1 Nanoscale Nanoscale NNP cord-309048-emmtplv3 257 2 8 8 CD cord-309048-emmtplv3 257 3 , , , cord-309048-emmtplv3 257 4 19853 19853 CD cord-309048-emmtplv3 257 5 ; ; : cord-309048-emmtplv3 257 6 panel panel NN cord-309048-emmtplv3 257 7 ( ( -LRB- cord-309048-emmtplv3 257 8 D D NNP cord-309048-emmtplv3 257 9 ) ) -RRB- cord-309048-emmtplv3 257 10 reproduced reproduce VBN cord-309048-emmtplv3 257 11 with with IN cord-309048-emmtplv3 257 12 permission permission NN cord-309048-emmtplv3 257 13 from from IN cord-309048-emmtplv3 257 14 Eber Eber NNP cord-309048-emmtplv3 257 15 , , , cord-309048-emmtplv3 257 16 F.J. F.J. NNP cord-309048-emmtplv3 257 17 , , , cord-309048-emmtplv3 257 18 Eiben Eiben NNP cord-309048-emmtplv3 257 19 , , , cord-309048-emmtplv3 257 20 S. S. NNP cord-309048-emmtplv3 257 21 , , , cord-309048-emmtplv3 257 22 Jeske Jeske NNP cord-309048-emmtplv3 257 23 , , , cord-309048-emmtplv3 257 24 H. H. NNP cord-309048-emmtplv3 257 25 , , , cord-309048-emmtplv3 257 26 Wege Wege NNP cord-309048-emmtplv3 257 27 , , , cord-309048-emmtplv3 257 28 C. C. NNP cord-309048-emmtplv3 257 29 , , , cord-309048-emmtplv3 257 30 2013 2013 CD cord-309048-emmtplv3 257 31 . . . cord-309048-emmtplv3 258 1 Bottom bottom JJ cord-309048-emmtplv3 258 2 - - HYPH cord-309048-emmtplv3 258 3 up up RB cord-309048-emmtplv3 258 4 - - HYPH cord-309048-emmtplv3 258 5 assembled assemble VBN cord-309048-emmtplv3 258 6 nanostar nanostar JJ cord-309048-emmtplv3 258 7 colloids colloid NNS cord-309048-emmtplv3 258 8 of of IN cord-309048-emmtplv3 258 9 gold gold NN cord-309048-emmtplv3 258 10 cores core NNS cord-309048-emmtplv3 258 11 and and CC cord-309048-emmtplv3 258 12 tubes tube NNS cord-309048-emmtplv3 258 13 derived derive VBN cord-309048-emmtplv3 258 14 from from IN cord-309048-emmtplv3 258 15 tobacco tobacco NN cord-309048-emmtplv3 258 16 mosaic mosaic JJ cord-309048-emmtplv3 258 17 virus virus NN cord-309048-emmtplv3 258 18 . . . cord-309048-emmtplv3 259 1 Angew Angew NNP cord-309048-emmtplv3 259 2 . . . cord-309048-emmtplv3 260 1 Chem Chem NNP cord-309048-emmtplv3 260 2 . . . cord-309048-emmtplv3 261 1 Int Int NNP cord-309048-emmtplv3 261 2 . . . cord-309048-emmtplv3 262 1 Ed Ed NNP cord-309048-emmtplv3 262 2 . . . cord-309048-emmtplv3 263 1 52 52 CD cord-309048-emmtplv3 263 2 , , , cord-309048-emmtplv3 263 3 7203 7203 CD cord-309048-emmtplv3 263 4 ; ; : cord-309048-emmtplv3 263 5 reproduced reproduce VBN cord-309048-emmtplv3 263 6 in in IN cord-309048-emmtplv3 263 7 agreement agreement NN cord-309048-emmtplv3 263 8 with with IN cord-309048-emmtplv3 263 9 the the DT cord-309048-emmtplv3 263 10 copyright copyright NN cord-309048-emmtplv3 263 11 terms term NNS cord-309048-emmtplv3 263 12 from from IN cord-309048-emmtplv3 263 13 Wenz Wenz NNP cord-309048-emmtplv3 263 14 , , , cord-309048-emmtplv3 263 15 N. N. NNP cord-309048-emmtplv3 263 16 , , , cord-309048-emmtplv3 263 17 Piasecka Piasecka NNP cord-309048-emmtplv3 263 18 , , , cord-309048-emmtplv3 263 19 S. S. NNP cord-309048-emmtplv3 263 20 , , , cord-309048-emmtplv3 263 21 Kalinowski Kalinowski NNP cord-309048-emmtplv3 263 22 , , , cord-309048-emmtplv3 263 23 M. M. NNP cord-309048-emmtplv3 263 24 , , , cord-309048-emmtplv3 263 25 Schneider Schneider NNP cord-309048-emmtplv3 263 26 , , , cord-309048-emmtplv3 263 27 A. A. NNP cord-309048-emmtplv3 263 28 , , , cord-309048-emmtplv3 263 29 Richert Richert NNP cord-309048-emmtplv3 263 30 , , , cord-309048-emmtplv3 263 31 C. C. NNP cord-309048-emmtplv3 263 32 , , , cord-309048-emmtplv3 263 33 Wege Wege NNP cord-309048-emmtplv3 263 34 , , , cord-309048-emmtplv3 263 35 C. C. NNP cord-309048-emmtplv3 263 36 , , , cord-309048-emmtplv3 263 37 2018 2018 CD cord-309048-emmtplv3 263 38 . . . cord-309048-emmtplv3 264 1 Building building NN cord-309048-emmtplv3 264 2 expanded expand VBD cord-309048-emmtplv3 264 3 structures structure NNS cord-309048-emmtplv3 264 4 from from IN cord-309048-emmtplv3 264 5 tetrahedral tetrahedral JJ cord-309048-emmtplv3 264 6 DNA dna NN cord-309048-emmtplv3 264 7 branching branching NN cord-309048-emmtplv3 264 8 elements element NNS cord-309048-emmtplv3 264 9 , , , cord-309048-emmtplv3 264 10 RNA RNA NNP cord-309048-emmtplv3 264 11 and and CC cord-309048-emmtplv3 264 12 TMV TMV NNP cord-309048-emmtplv3 264 13 protein protein NN cord-309048-emmtplv3 264 14 . . . cord-309048-emmtplv3 265 1 Nanoscale nanoscale NN cord-309048-emmtplv3 265 2 10 10 CD cord-309048-emmtplv3 265 3 , , , cord-309048-emmtplv3 265 4 6496 6496 CD cord-309048-emmtplv3 265 5 . . . cord-309048-emmtplv3 266 1 The the DT cord-309048-emmtplv3 266 2 display display NN cord-309048-emmtplv3 266 3 of of IN cord-309048-emmtplv3 266 4 active active JJ cord-309048-emmtplv3 266 5 enzymes enzyme NNS cord-309048-emmtplv3 266 6 of of IN cord-309048-emmtplv3 266 7 the the DT cord-309048-emmtplv3 266 8 surface surface NN cord-309048-emmtplv3 266 9 of of IN cord-309048-emmtplv3 266 10 TMV TMV NNP cord-309048-emmtplv3 266 11 particles particle NNS cord-309048-emmtplv3 266 12 is be VBZ cord-309048-emmtplv3 266 13 of of IN cord-309048-emmtplv3 266 14 great great JJ cord-309048-emmtplv3 266 15 interest interest NN cord-309048-emmtplv3 266 16 to to IN cord-309048-emmtplv3 266 17 many many JJ cord-309048-emmtplv3 266 18 fields field NNS cord-309048-emmtplv3 266 19 , , , cord-309048-emmtplv3 266 20 including include VBG cord-309048-emmtplv3 266 21 medicine medicine NN cord-309048-emmtplv3 266 22 , , , cord-309048-emmtplv3 266 23 biodetection biodetection NN cord-309048-emmtplv3 266 24 , , , cord-309048-emmtplv3 266 25 the the DT cord-309048-emmtplv3 266 26 development development NN cord-309048-emmtplv3 266 27 of of IN cord-309048-emmtplv3 266 28 sensors sensor NNS cord-309048-emmtplv3 266 29 , , , cord-309048-emmtplv3 266 30 and and CC cord-309048-emmtplv3 266 31 even even RB cord-309048-emmtplv3 266 32 small small JJ cord-309048-emmtplv3 266 33 - - HYPH cord-309048-emmtplv3 266 34 scale scale NN cord-309048-emmtplv3 266 35 enzymatic enzymatic JJ cord-309048-emmtplv3 266 36 conversions conversion NNS cord-309048-emmtplv3 266 37 ( ( -LRB- cord-309048-emmtplv3 266 38 Fig fig NN cord-309048-emmtplv3 266 39 . . NNP cord-309048-emmtplv3 266 40 2 2 CD cord-309048-emmtplv3 266 41 ) ) -RRB- cord-309048-emmtplv3 266 42 . . . cord-309048-emmtplv3 267 1 The the DT cord-309048-emmtplv3 267 2 surface surface NN cord-309048-emmtplv3 267 3 of of IN cord-309048-emmtplv3 267 4 TMV TMV NNP cord-309048-emmtplv3 267 5 has have VBZ cord-309048-emmtplv3 267 6 a a DT cord-309048-emmtplv3 267 7 strong strong JJ cord-309048-emmtplv3 267 8 stabilizing stabilize VBG cord-309048-emmtplv3 267 9 effect effect NN cord-309048-emmtplv3 267 10 on on IN cord-309048-emmtplv3 267 11 different different JJ cord-309048-emmtplv3 267 12 enzymes enzyme NNS cord-309048-emmtplv3 267 13 , , , cord-309048-emmtplv3 267 14 including include VBG cord-309048-emmtplv3 267 15 glucose glucose NN cord-309048-emmtplv3 267 16 oxidase oxidase NN cord-309048-emmtplv3 267 17 , , , cord-309048-emmtplv3 267 18 horseradish horseradish NN cord-309048-emmtplv3 267 19 peroxidase peroxidase NN cord-309048-emmtplv3 267 20 ( ( -LRB- cord-309048-emmtplv3 267 21 Baecker Baecker NNP cord-309048-emmtplv3 267 22 et et NNP cord-309048-emmtplv3 267 23 al al NNP cord-309048-emmtplv3 267 24 . . NNP cord-309048-emmtplv3 267 25 , , , cord-309048-emmtplv3 267 26 2017 2017 CD cord-309048-emmtplv3 267 27 ; ; : cord-309048-emmtplv3 267 28 Koch Koch NNP cord-309048-emmtplv3 267 29 et et NNP cord-309048-emmtplv3 267 30 al al NNP cord-309048-emmtplv3 267 31 . . NNP cord-309048-emmtplv3 267 32 , , , cord-309048-emmtplv3 267 33 2015 2015 CD cord-309048-emmtplv3 267 34 ) ) -RRB- cord-309048-emmtplv3 267 35 , , , cord-309048-emmtplv3 267 36 and and CC cord-309048-emmtplv3 267 37 penicillinase penicillinase NNP cord-309048-emmtplv3 267 38 Poghossian Poghossian NNP cord-309048-emmtplv3 267 39 et et NNP cord-309048-emmtplv3 267 40 al al NNP cord-309048-emmtplv3 267 41 . . NNP cord-309048-emmtplv3 267 42 , , , cord-309048-emmtplv3 267 43 2018 2018 CD cord-309048-emmtplv3 267 44 ) ) -RRB- cord-309048-emmtplv3 267 45 . . . cord-309048-emmtplv3 268 1 The the DT cord-309048-emmtplv3 268 2 use use NN cord-309048-emmtplv3 268 3 of of IN cord-309048-emmtplv3 268 4 TMV TMV NNP cord-309048-emmtplv3 268 5 adapter adapter NN cord-309048-emmtplv3 268 6 rods rod NNS cord-309048-emmtplv3 268 7 on on IN cord-309048-emmtplv3 268 8 sensor sensor NN cord-309048-emmtplv3 268 9 surfaces surface NNS cord-309048-emmtplv3 268 10 ( ( -LRB- cord-309048-emmtplv3 268 11 see see VB cord-309048-emmtplv3 268 12 below below RB cord-309048-emmtplv3 268 13 ) ) -RRB- cord-309048-emmtplv3 268 14 also also RB cord-309048-emmtplv3 268 15 has have VBZ cord-309048-emmtplv3 268 16 enabled enable VBN cord-309048-emmtplv3 268 17 bioaffinity bioaffinity NN cord-309048-emmtplv3 268 18 - - HYPH cord-309048-emmtplv3 268 19 based base VBN cord-309048-emmtplv3 268 20 display display NN cord-309048-emmtplv3 268 21 of of IN cord-309048-emmtplv3 268 22 streptavidin streptavidin NNP cord-309048-emmtplv3 268 23 conjugates conjugate NNS cord-309048-emmtplv3 268 24 of of IN cord-309048-emmtplv3 268 25 these these DT cord-309048-emmtplv3 268 26 enzymes enzyme NNS cord-309048-emmtplv3 268 27 at at IN cord-309048-emmtplv3 268 28 surface surface NN cord-309048-emmtplv3 268 29 densities density NNS cord-309048-emmtplv3 268 30 not not RB cord-309048-emmtplv3 268 31 achievable achievable JJ cord-309048-emmtplv3 268 32 on on IN cord-309048-emmtplv3 268 33 TMV TMV NNP cord-309048-emmtplv3 268 34 - - HYPH cord-309048-emmtplv3 268 35 free free JJ cord-309048-emmtplv3 268 36 supports support NNS cord-309048-emmtplv3 268 37 , , , cord-309048-emmtplv3 268 38 with with IN cord-309048-emmtplv3 268 39 the the DT cord-309048-emmtplv3 268 40 additional additional JJ cord-309048-emmtplv3 268 41 advantages advantage NNS cord-309048-emmtplv3 268 42 of of IN cord-309048-emmtplv3 268 43 increased increase VBN cord-309048-emmtplv3 268 44 reusability reusability NN cord-309048-emmtplv3 268 45 and and CC cord-309048-emmtplv3 268 46 enhanced enhanced JJ cord-309048-emmtplv3 268 47 target target NN cord-309048-emmtplv3 268 48 detection detection NN cord-309048-emmtplv3 268 49 ranges range NNS cord-309048-emmtplv3 268 50 of of IN cord-309048-emmtplv3 268 51 such such JJ cord-309048-emmtplv3 268 52 devices device NNS cord-309048-emmtplv3 268 53 . . . cord-309048-emmtplv3 269 1 Thus thus RB cord-309048-emmtplv3 269 2 , , , cord-309048-emmtplv3 269 3 it -PRON- PRP cord-309048-emmtplv3 269 4 is be VBZ cord-309048-emmtplv3 269 5 anticipated anticipate VBN cord-309048-emmtplv3 269 6 that that IN cord-309048-emmtplv3 269 7 high high JJ cord-309048-emmtplv3 269 8 - - HYPH cord-309048-emmtplv3 269 9 performance performance NN cord-309048-emmtplv3 269 10 biosensors biosensor NNS cord-309048-emmtplv3 269 11 employing employ VBG cord-309048-emmtplv3 269 12 TMV TMV NNP cord-309048-emmtplv3 269 13 rods rod NNS cord-309048-emmtplv3 269 14 will will MD cord-309048-emmtplv3 269 15 soon soon RB cord-309048-emmtplv3 269 16 be be VB cord-309048-emmtplv3 269 17 used use VBN cord-309048-emmtplv3 269 18 in in IN cord-309048-emmtplv3 269 19 proof proof NN cord-309048-emmtplv3 269 20 - - HYPH cord-309048-emmtplv3 269 21 of of IN cord-309048-emmtplv3 269 22 - - HYPH cord-309048-emmtplv3 269 23 concept concept NN cord-309048-emmtplv3 269 24 applications application NNS cord-309048-emmtplv3 269 25 . . . cord-309048-emmtplv3 270 1 The the DT cord-309048-emmtplv3 270 2 adsorption adsorption NN cord-309048-emmtplv3 270 3 properties property NNS cord-309048-emmtplv3 270 4 of of IN cord-309048-emmtplv3 270 5 TMV TMV NNP cord-309048-emmtplv3 270 6 on on IN cord-309048-emmtplv3 270 7 various various JJ cord-309048-emmtplv3 270 8 surfaces surface NNS cord-309048-emmtplv3 270 9 such such JJ cord-309048-emmtplv3 270 10 as as IN cord-309048-emmtplv3 270 11 gold gold NN cord-309048-emmtplv3 270 12 , , , cord-309048-emmtplv3 270 13 mica mica NN cord-309048-emmtplv3 270 14 , , , cord-309048-emmtplv3 270 15 glass glass NN cord-309048-emmtplv3 270 16 , , , cord-309048-emmtplv3 270 17 and and CC cord-309048-emmtplv3 270 18 silicon silicon NN cord-309048-emmtplv3 270 19 wafers wafer NNS cord-309048-emmtplv3 270 20 have have VBP cord-309048-emmtplv3 270 21 been be VBN cord-309048-emmtplv3 270 22 investigated investigate VBN cord-309048-emmtplv3 270 23 in in IN cord-309048-emmtplv3 270 24 detail detail NN cord-309048-emmtplv3 270 25 ( ( -LRB- cord-309048-emmtplv3 271 1 Knez Knez NNP cord-309048-emmtplv3 271 2 et et FW cord-309048-emmtplv3 271 3 al al NNP cord-309048-emmtplv3 271 4 . . NNP cord-309048-emmtplv3 271 5 , , , cord-309048-emmtplv3 271 6 2004a 2004a CD cord-309048-emmtplv3 271 7 ) ) -RRB- cord-309048-emmtplv3 271 8 . . . cord-309048-emmtplv3 272 1 Techniques technique NNS cord-309048-emmtplv3 272 2 such such JJ cord-309048-emmtplv3 272 3 as as IN cord-309048-emmtplv3 272 4 convective convective JJ cord-309048-emmtplv3 272 5 deposition deposition NN cord-309048-emmtplv3 272 6 , , , cord-309048-emmtplv3 272 7 microcontact microcontact NNP cord-309048-emmtplv3 272 8 printing printing NN cord-309048-emmtplv3 272 9 ( ( -LRB- cord-309048-emmtplv3 272 10 e.g. e.g. RB cord-309048-emmtplv3 272 11 , , , cord-309048-emmtplv3 272 12 Kuncicky Kuncicky NNP cord-309048-emmtplv3 272 13 et et NNP cord-309048-emmtplv3 272 14 al al NNP cord-309048-emmtplv3 272 15 . . NNP cord-309048-emmtplv3 272 16 , , , cord-309048-emmtplv3 272 17 2006 2006 CD cord-309048-emmtplv3 272 18 ) ) -RRB- cord-309048-emmtplv3 272 19 , , , cord-309048-emmtplv3 272 20 and and CC cord-309048-emmtplv3 272 21 a a DT cord-309048-emmtplv3 272 22 number number NN cord-309048-emmtplv3 272 23 of of IN cord-309048-emmtplv3 272 24 evaporation evaporation NN cord-309048-emmtplv3 272 25 - - HYPH cord-309048-emmtplv3 272 26 based base VBN cord-309048-emmtplv3 272 27 methods method NNS cord-309048-emmtplv3 272 28 for for IN cord-309048-emmtplv3 272 29 rapid rapid JJ cord-309048-emmtplv3 272 30 and and CC cord-309048-emmtplv3 272 31 large large JJ cord-309048-emmtplv3 272 32 - - HYPH cord-309048-emmtplv3 272 33 scale scale NN cord-309048-emmtplv3 272 34 assembly assembly NN cord-309048-emmtplv3 272 35 of of IN cord-309048-emmtplv3 272 36 thin thin JJ cord-309048-emmtplv3 272 37 film film NN cord-309048-emmtplv3 272 38 coatings coating NNS cord-309048-emmtplv3 272 39 and and CC cord-309048-emmtplv3 272 40 ordered order VBN cord-309048-emmtplv3 272 41 fibers fiber NNS cord-309048-emmtplv3 272 42 consisting consist VBG cord-309048-emmtplv3 272 43 of of IN cord-309048-emmtplv3 272 44 aligned align VBN cord-309048-emmtplv3 272 45 TMV TMV NNP cord-309048-emmtplv3 272 46 particles particle NNS cord-309048-emmtplv3 272 47 also also RB cord-309048-emmtplv3 272 48 have have VBP cord-309048-emmtplv3 272 49 been be VBN cord-309048-emmtplv3 272 50 reported report VBN cord-309048-emmtplv3 272 51 . . . cord-309048-emmtplv3 273 1 The the DT cord-309048-emmtplv3 273 2 effects effect NNS cord-309048-emmtplv3 273 3 of of IN cord-309048-emmtplv3 273 4 divalent divalent JJ cord-309048-emmtplv3 273 5 metal metal NN cord-309048-emmtplv3 273 6 ions ion NNS cord-309048-emmtplv3 273 7 ( ( -LRB- cord-309048-emmtplv3 273 8 Nedoluzhko Nedoluzhko NNP cord-309048-emmtplv3 273 9 and and CC cord-309048-emmtplv3 273 10 Douglas Douglas NNP cord-309048-emmtplv3 273 11 , , , cord-309048-emmtplv3 273 12 2001 2001 CD cord-309048-emmtplv3 273 13 ) ) -RRB- cord-309048-emmtplv3 273 14 and and CC cord-309048-emmtplv3 273 15 other other JJ cord-309048-emmtplv3 273 16 additives additive NNS cord-309048-emmtplv3 273 17 also also RB cord-309048-emmtplv3 273 18 have have VBP cord-309048-emmtplv3 273 19 been be VBN cord-309048-emmtplv3 273 20 evaluated evaluate VBN cord-309048-emmtplv3 273 21 in in IN cord-309048-emmtplv3 273 22 detail detail NN cord-309048-emmtplv3 273 23 , , , cord-309048-emmtplv3 273 24 resulting result VBG cord-309048-emmtplv3 273 25 in in IN cord-309048-emmtplv3 273 26 the the DT cord-309048-emmtplv3 273 27 development development NN cord-309048-emmtplv3 273 28 of of IN cord-309048-emmtplv3 273 29 long long JJ cord-309048-emmtplv3 273 30 - - HYPH cord-309048-emmtplv3 273 31 range range NN cord-309048-emmtplv3 273 32 deposition deposition NN cord-309048-emmtplv3 273 33 techniques technique NNS cord-309048-emmtplv3 273 34 as as RB cord-309048-emmtplv3 273 35 well well RB cord-309048-emmtplv3 273 36 as as IN cord-309048-emmtplv3 273 37 several several JJ cord-309048-emmtplv3 273 38 unique unique JJ cord-309048-emmtplv3 273 39 approaches approach NNS cord-309048-emmtplv3 273 40 . . . cord-309048-emmtplv3 274 1 These these DT cord-309048-emmtplv3 274 2 comprise comprise VBP cord-309048-emmtplv3 274 3 , , , cord-309048-emmtplv3 274 4 among among IN cord-309048-emmtplv3 274 5 others other NNS cord-309048-emmtplv3 274 6 , , , cord-309048-emmtplv3 274 7 the the DT cord-309048-emmtplv3 274 8 spatially spatially RB cord-309048-emmtplv3 274 9 directed direct VBN cord-309048-emmtplv3 274 10 assembly assembly NN cord-309048-emmtplv3 274 11 of of IN cord-309048-emmtplv3 274 12 patterned pattern VBN cord-309048-emmtplv3 274 13 TMV TMV NNP cord-309048-emmtplv3 274 14 structures structure NNS cord-309048-emmtplv3 274 15 in in IN cord-309048-emmtplv3 274 16 capillary capillary JJ cord-309048-emmtplv3 274 17 tubes tube NNS cord-309048-emmtplv3 274 18 ( ( -LRB- cord-309048-emmtplv3 274 19 Lin Lin NNP cord-309048-emmtplv3 274 20 et et NNP cord-309048-emmtplv3 274 21 al al NNP cord-309048-emmtplv3 274 22 . . NNP cord-309048-emmtplv3 274 23 , , , cord-309048-emmtplv3 274 24 2010 2010 CD cord-309048-emmtplv3 274 25 ) ) -RRB- cord-309048-emmtplv3 274 26 and and CC cord-309048-emmtplv3 274 27 the the DT cord-309048-emmtplv3 274 28 oriented orient VBN cord-309048-emmtplv3 274 29 growth growth NN cord-309048-emmtplv3 274 30 of of IN cord-309048-emmtplv3 274 31 TMV TMV NNP cord-309048-emmtplv3 274 32 fiber fiber NN cord-309048-emmtplv3 274 33 bundles bundle NNS cord-309048-emmtplv3 274 34 on on IN cord-309048-emmtplv3 274 35 nanopillar nanopillar JJ cord-309048-emmtplv3 274 36 structured structured JJ cord-309048-emmtplv3 274 37 superhydrophobic superhydrophobic JJ cord-309048-emmtplv3 274 38 surfaces surface NNS cord-309048-emmtplv3 274 39 ( ( -LRB- cord-309048-emmtplv3 274 40 Marinaro Marinaro NNP cord-309048-emmtplv3 274 41 et et FW cord-309048-emmtplv3 274 42 al al NNP cord-309048-emmtplv3 274 43 . . NNP cord-309048-emmtplv3 274 44 , , , cord-309048-emmtplv3 274 45 2015 2015 CD cord-309048-emmtplv3 274 46 ) ) -RRB- cord-309048-emmtplv3 274 47 . . . cord-309048-emmtplv3 275 1 Of of IN cord-309048-emmtplv3 275 2 particular particular JJ cord-309048-emmtplv3 275 3 importance importance NN cord-309048-emmtplv3 275 4 for for IN cord-309048-emmtplv3 275 5 close close JJ cord-309048-emmtplv3 275 6 - - HYPH cord-309048-emmtplv3 275 7 to to IN cord-309048-emmtplv3 275 8 - - HYPH cord-309048-emmtplv3 275 9 application application NN cord-309048-emmtplv3 275 10 formulations formulation NNS cord-309048-emmtplv3 275 11 is be VBZ cord-309048-emmtplv3 275 12 the the DT cord-309048-emmtplv3 275 13 observation observation NN cord-309048-emmtplv3 275 14 that that IN cord-309048-emmtplv3 275 15 nanorods nanorods NNP cord-309048-emmtplv3 275 16 containing contain VBG cord-309048-emmtplv3 275 17 cysteine cysteine NN cord-309048-emmtplv3 275 18 - - HYPH cord-309048-emmtplv3 275 19 exposed expose VBN cord-309048-emmtplv3 275 20 TMV TMV NNP cord-309048-emmtplv3 275 21 CP CP NNP cord-309048-emmtplv3 275 22 mutants mutant NNS cord-309048-emmtplv3 275 23 adopt adopt VBP cord-309048-emmtplv3 275 24 a a DT cord-309048-emmtplv3 275 25 primarily primarily RB cord-309048-emmtplv3 275 26 vertical vertical JJ cord-309048-emmtplv3 275 27 orientation orientation NN cord-309048-emmtplv3 275 28 on on IN cord-309048-emmtplv3 275 29 certain certain JJ cord-309048-emmtplv3 275 30 substrates substrate NNS cord-309048-emmtplv3 275 31 , , , cord-309048-emmtplv3 275 32 such such JJ cord-309048-emmtplv3 275 33 as as IN cord-309048-emmtplv3 275 34 gold gold NN cord-309048-emmtplv3 275 35 , , , cord-309048-emmtplv3 275 36 under under IN cord-309048-emmtplv3 275 37 suitable suitable JJ cord-309048-emmtplv3 275 38 conditions condition NNS cord-309048-emmtplv3 275 39 ( ( -LRB- cord-309048-emmtplv3 275 40 Peng Peng NNP cord-309048-emmtplv3 275 41 et et NNP cord-309048-emmtplv3 275 42 al al NNP cord-309048-emmtplv3 275 43 . . NNP cord-309048-emmtplv3 275 44 , , , cord-309048-emmtplv3 275 45 2011 2011 CD cord-309048-emmtplv3 275 46 ; ; : cord-309048-emmtplv3 275 47 Royston Royston NNP cord-309048-emmtplv3 275 48 et et NNP cord-309048-emmtplv3 275 49 al al NNP cord-309048-emmtplv3 275 50 . . NNP cord-309048-emmtplv3 275 51 , , , cord-309048-emmtplv3 275 52 2008 2008 CD cord-309048-emmtplv3 275 53 ) ) -RRB- cord-309048-emmtplv3 275 54 . . . cord-309048-emmtplv3 276 1 This this DT cord-309048-emmtplv3 276 2 has have VBZ cord-309048-emmtplv3 276 3 been be VBN cord-309048-emmtplv3 276 4 exploited exploit VBN cord-309048-emmtplv3 276 5 for for IN cord-309048-emmtplv3 276 6 increasing increase VBG cord-309048-emmtplv3 276 7 the the DT cord-309048-emmtplv3 276 8 efficiency efficiency NN cord-309048-emmtplv3 276 9 of of IN cord-309048-emmtplv3 276 10 energy energy NN cord-309048-emmtplv3 276 11 storage storage NN cord-309048-emmtplv3 276 12 and and CC cord-309048-emmtplv3 276 13 conversion conversion NN cord-309048-emmtplv3 276 14 devices device NNS cord-309048-emmtplv3 276 15 as as IN cord-309048-emmtplv3 276 16 outlined outline VBN cord-309048-emmtplv3 276 17 earlier early RBR cord-309048-emmtplv3 276 18 . . . cord-309048-emmtplv3 277 1 To to TO cord-309048-emmtplv3 277 2 generate generate VB cord-309048-emmtplv3 277 3 controlled control VBN cord-309048-emmtplv3 277 4 arrays array NNS cord-309048-emmtplv3 277 5 of of IN cord-309048-emmtplv3 277 6 TMV TMV NNP cord-309048-emmtplv3 277 7 particles particle NNS cord-309048-emmtplv3 277 8 , , , cord-309048-emmtplv3 277 9 Yi Yi NNP cord-309048-emmtplv3 277 10 et et FW cord-309048-emmtplv3 277 11 al al NNP cord-309048-emmtplv3 277 12 . . . cord-309048-emmtplv3 278 1 ( ( -LRB- cord-309048-emmtplv3 278 2 2005 2005 CD cord-309048-emmtplv3 278 3 Yi Yi NNP cord-309048-emmtplv3 278 4 et et FW cord-309048-emmtplv3 278 5 al al NNP cord-309048-emmtplv3 278 6 . . . cord-309048-emmtplv3 279 1 ( ( -LRB- cord-309048-emmtplv3 279 2 , , , cord-309048-emmtplv3 279 3 2007 2007 CD cord-309048-emmtplv3 279 4 partially partially RB cord-309048-emmtplv3 279 5 disassembled disassemble VBD cord-309048-emmtplv3 279 6 the the DT cord-309048-emmtplv3 279 7 CP cp NN cord-309048-emmtplv3 279 8 from from IN cord-309048-emmtplv3 279 9 TMV TMV NNP cord-309048-emmtplv3 279 10 particles particle NNS cord-309048-emmtplv3 279 11 to to TO cord-309048-emmtplv3 279 12 expose expose VB cord-309048-emmtplv3 279 13 the the DT cord-309048-emmtplv3 279 14 RNA RNA NNP cord-309048-emmtplv3 279 15 at at IN cord-309048-emmtplv3 279 16 the the DT cord-309048-emmtplv3 279 17 5 5 CD cord-309048-emmtplv3 279 18 0 0 CD cord-309048-emmtplv3 279 19 end end NN cord-309048-emmtplv3 279 20 of of IN cord-309048-emmtplv3 279 21 the the DT cord-309048-emmtplv3 279 22 rods rod NNS cord-309048-emmtplv3 279 23 . . . cord-309048-emmtplv3 280 1 Oriented orient VBN cord-309048-emmtplv3 280 2 assembly assembly NN cord-309048-emmtplv3 280 3 of of IN cord-309048-emmtplv3 280 4 TMV TMV NNP cord-309048-emmtplv3 280 5 on on IN cord-309048-emmtplv3 280 6 solid solid JJ cord-309048-emmtplv3 280 7 supports support NNS cord-309048-emmtplv3 280 8 was be VBD cord-309048-emmtplv3 280 9 then then RB cord-309048-emmtplv3 280 10 achieved achieve VBN cord-309048-emmtplv3 280 11 in in IN cord-309048-emmtplv3 280 12 a a DT cord-309048-emmtplv3 280 13 controlled control VBN cord-309048-emmtplv3 280 14 manner manner NN cord-309048-emmtplv3 280 15 via via IN cord-309048-emmtplv3 280 16 nucleic nucleic JJ cord-309048-emmtplv3 280 17 acid acid NN cord-309048-emmtplv3 280 18 hybridization hybridization NN cord-309048-emmtplv3 280 19 using use VBG cord-309048-emmtplv3 280 20 complementary complementary JJ cord-309048-emmtplv3 280 21 oligonucleotides oligonucleotide NNS cord-309048-emmtplv3 280 22 . . . cord-309048-emmtplv3 281 1 By by IN cord-309048-emmtplv3 281 2 this this DT cord-309048-emmtplv3 281 3 approach approach NN cord-309048-emmtplv3 281 4 , , , cord-309048-emmtplv3 281 5 the the DT cord-309048-emmtplv3 281 6 immobilization immobilization NN cord-309048-emmtplv3 281 7 of of IN cord-309048-emmtplv3 281 8 fluorescently fluorescently RB cord-309048-emmtplv3 281 9 labeled label VBN cord-309048-emmtplv3 281 10 TMV TMV NNP cord-309048-emmtplv3 281 11 onto onto IN cord-309048-emmtplv3 281 12 electrodes electrode NNS cord-309048-emmtplv3 281 13 could could MD cord-309048-emmtplv3 281 14 be be VB cord-309048-emmtplv3 281 15 demonstrated demonstrate VBN cord-309048-emmtplv3 281 16 . . . cord-309048-emmtplv3 282 1 Furthermore furthermore RB cord-309048-emmtplv3 282 2 , , , cord-309048-emmtplv3 282 3 by by IN cord-309048-emmtplv3 282 4 using use VBG cord-309048-emmtplv3 282 5 differentially differentially RB cord-309048-emmtplv3 282 6 labeled label VBN cord-309048-emmtplv3 282 7 TMV TMV NNP cord-309048-emmtplv3 282 8 particles particle NNS cord-309048-emmtplv3 282 9 in in IN cord-309048-emmtplv3 282 10 conjunction conjunction NN cord-309048-emmtplv3 282 11 with with IN cord-309048-emmtplv3 282 12 a a DT cord-309048-emmtplv3 282 13 micropatterned micropatterne VBN cord-309048-emmtplv3 282 14 substrate substrate NN cord-309048-emmtplv3 282 15 , , , cord-309048-emmtplv3 282 16 it -PRON- PRP cord-309048-emmtplv3 282 17 was be VBD cord-309048-emmtplv3 282 18 possible possible JJ cord-309048-emmtplv3 282 19 to to TO cord-309048-emmtplv3 282 20 construct construct VB cord-309048-emmtplv3 282 21 a a DT cord-309048-emmtplv3 282 22 patterned pattern VBN cord-309048-emmtplv3 282 23 TMV tmv NN cord-309048-emmtplv3 282 24 microarray microarray NN cord-309048-emmtplv3 282 25 ( ( -LRB- cord-309048-emmtplv3 282 26 Tan Tan NNP cord-309048-emmtplv3 282 27 et et FW cord-309048-emmtplv3 282 28 al al NNP cord-309048-emmtplv3 282 29 . . NNP cord-309048-emmtplv3 282 30 , , , cord-309048-emmtplv3 282 31 2008 2008 CD cord-309048-emmtplv3 282 32 ) ) -RRB- cord-309048-emmtplv3 282 33 . . . cord-309048-emmtplv3 283 1 An an DT cord-309048-emmtplv3 283 2 alternative alternative JJ cord-309048-emmtplv3 283 3 approach approach NN cord-309048-emmtplv3 283 4 made make VBD cord-309048-emmtplv3 283 5 use use NN cord-309048-emmtplv3 283 6 of of IN cord-309048-emmtplv3 283 7 the the DT cord-309048-emmtplv3 283 8 viral viral JJ cord-309048-emmtplv3 283 9 self self NN cord-309048-emmtplv3 283 10 - - HYPH cord-309048-emmtplv3 283 11 assembly assembly NN cord-309048-emmtplv3 283 12 mechanism mechanism NN cord-309048-emmtplv3 283 13 predicted predict VBD cord-309048-emmtplv3 283 14 to to TO cord-309048-emmtplv3 283 15 function function VB cord-309048-emmtplv3 283 16 not not RB cord-309048-emmtplv3 283 17 only only RB cord-309048-emmtplv3 283 18 in in IN cord-309048-emmtplv3 283 19 solution solution NN cord-309048-emmtplv3 283 20 but but CC cord-309048-emmtplv3 283 21 also also RB cord-309048-emmtplv3 283 22 on on IN cord-309048-emmtplv3 283 23 3 3 CD cord-309048-emmtplv3 283 24 0terminally 0terminally CD cord-309048-emmtplv3 283 25 immobilized immobilized JJ cord-309048-emmtplv3 283 26 RNAs rna NNS cord-309048-emmtplv3 283 27 containing contain VBG cord-309048-emmtplv3 283 28 the the DT cord-309048-emmtplv3 283 29 viral viral JJ cord-309048-emmtplv3 283 30 OAS OAS NNP cord-309048-emmtplv3 283 31 sequence sequence NN cord-309048-emmtplv3 283 32 . . . cord-309048-emmtplv3 284 1 Indeed indeed RB cord-309048-emmtplv3 284 2 it -PRON- PRP cord-309048-emmtplv3 284 3 was be VBD cord-309048-emmtplv3 284 4 possible possible JJ cord-309048-emmtplv3 284 5 to to TO cord-309048-emmtplv3 284 6 grow grow VB cord-309048-emmtplv3 284 7 nanostick nanostick JJ cord-309048-emmtplv3 284 8 arrays array NNS cord-309048-emmtplv3 284 9 bottom bottom NN cord-309048-emmtplv3 284 10 - - HYPH cord-309048-emmtplv3 284 11 up up NN cord-309048-emmtplv3 284 12 on on IN cord-309048-emmtplv3 284 13 different different JJ cord-309048-emmtplv3 284 14 solid solid JJ cord-309048-emmtplv3 284 15 supports support NNS cord-309048-emmtplv3 284 16 , , , cord-309048-emmtplv3 284 17 including include VBG cord-309048-emmtplv3 284 18 prepatterned prepatterned NN cord-309048-emmtplv3 284 19 flat flat JJ cord-309048-emmtplv3 284 20 substrates substrate NNS cord-309048-emmtplv3 284 21 , , , cord-309048-emmtplv3 284 22 with with IN cord-309048-emmtplv3 284 23 covalently covalently RB cord-309048-emmtplv3 284 24 conjugated conjugate VBN cord-309048-emmtplv3 284 25 RNA RNA NNP cord-309048-emmtplv3 284 26 scaffolds scaffold NNS cord-309048-emmtplv3 284 27 ( ( -LRB- cord-309048-emmtplv3 284 28 Mueller Mueller NNP cord-309048-emmtplv3 284 29 et et NNP cord-309048-emmtplv3 284 30 al al NNP cord-309048-emmtplv3 284 31 . . NNP cord-309048-emmtplv3 284 32 , , , cord-309048-emmtplv3 284 33 2011 2011 CD cord-309048-emmtplv3 284 34 ) ) -RRB- cord-309048-emmtplv3 284 35 , , , cord-309048-emmtplv3 284 36 and and CC cord-309048-emmtplv3 284 37 on on IN cord-309048-emmtplv3 284 38 DNA dna NN cord-309048-emmtplv3 284 39 - - HYPH cord-309048-emmtplv3 284 40 programmed program VBN cord-309048-emmtplv3 284 41 gold gold NN cord-309048-emmtplv3 284 42 nanobeads nanobead NNS cord-309048-emmtplv3 284 43 after after IN cord-309048-emmtplv3 284 44 sequence sequence NN cord-309048-emmtplv3 284 45 - - HYPH cord-309048-emmtplv3 284 46 selective selective JJ cord-309048-emmtplv3 284 47 hybridization hybridization NN cord-309048-emmtplv3 284 48 of of IN cord-309048-emmtplv3 284 49 RNAs rna NNS cord-309048-emmtplv3 284 50 via via IN cord-309048-emmtplv3 284 51 their -PRON- PRP$ cord-309048-emmtplv3 284 52 3 3 CD cord-309048-emmtplv3 284 53 0 0 CD cord-309048-emmtplv3 284 54 ends end NNS cord-309048-emmtplv3 284 55 . . . cord-309048-emmtplv3 285 1 This this DT cord-309048-emmtplv3 285 2 resulted result VBD cord-309048-emmtplv3 285 3 in in IN cord-309048-emmtplv3 285 4 the the DT cord-309048-emmtplv3 285 5 formation formation NN cord-309048-emmtplv3 285 6 of of IN cord-309048-emmtplv3 285 7 nanostar nanostar JJ cord-309048-emmtplv3 285 8 colloids colloid NNS cord-309048-emmtplv3 285 9 with with IN cord-309048-emmtplv3 285 10 an an DT cord-309048-emmtplv3 285 11 adjustable adjustable JJ cord-309048-emmtplv3 285 12 number number NN cord-309048-emmtplv3 285 13 of of IN cord-309048-emmtplv3 285 14 TMV TMV NNP cord-309048-emmtplv3 285 15 arms arm NNS cord-309048-emmtplv3 285 16 with with IN cord-309048-emmtplv3 285 17 varying vary VBG cord-309048-emmtplv3 285 18 lengths length NNS cord-309048-emmtplv3 285 19 . . . cord-309048-emmtplv3 286 1 Such such JJ cord-309048-emmtplv3 286 2 composite composite JJ cord-309048-emmtplv3 286 3 structures structure NNS cord-309048-emmtplv3 286 4 suggest suggest VBP cord-309048-emmtplv3 286 5 themselves -PRON- PRP cord-309048-emmtplv3 286 6 as as IN cord-309048-emmtplv3 286 7 carrier carrier NN cord-309048-emmtplv3 286 8 colloids colloid NNS cord-309048-emmtplv3 286 9 for for IN cord-309048-emmtplv3 286 10 functional functional JJ cord-309048-emmtplv3 286 11 molecules molecule NNS cord-309048-emmtplv3 286 12 , , , cord-309048-emmtplv3 286 13 with with IN cord-309048-emmtplv3 286 14 applications application NNS cord-309048-emmtplv3 286 15 ranging range VBG cord-309048-emmtplv3 286 16 from from IN cord-309048-emmtplv3 286 17 separation separation NN cord-309048-emmtplv3 286 18 to to IN cord-309048-emmtplv3 286 19 biodetection biodetection NN cord-309048-emmtplv3 286 20 methods method NNS cord-309048-emmtplv3 286 21 . . . cord-309048-emmtplv3 287 1 Initial initial JJ cord-309048-emmtplv3 287 2 attempts attempt NNS cord-309048-emmtplv3 287 3 to to TO cord-309048-emmtplv3 287 4 incorporate incorporate VB cord-309048-emmtplv3 287 5 TMV TMV NNP cord-309048-emmtplv3 287 6 particles particle NNS cord-309048-emmtplv3 287 7 into into IN cord-309048-emmtplv3 287 8 multilayers multilayer NNS cord-309048-emmtplv3 287 9 using use VBG cord-309048-emmtplv3 287 10 electrostatic electrostatic JJ cord-309048-emmtplv3 287 11 interactions interaction NNS cord-309048-emmtplv3 287 12 revealed reveal VBD cord-309048-emmtplv3 287 13 that that IN cord-309048-emmtplv3 287 14 , , , cord-309048-emmtplv3 287 15 unlike unlike IN cord-309048-emmtplv3 287 16 spherical spherical JJ cord-309048-emmtplv3 287 17 cowpea cowpea NN cord-309048-emmtplv3 287 18 mosaic mosaic NN cord-309048-emmtplv3 287 19 virus virus NN cord-309048-emmtplv3 287 20 particles particle NNS cord-309048-emmtplv3 287 21 , , , cord-309048-emmtplv3 287 22 the the DT cord-309048-emmtplv3 287 23 rods rod NNS cord-309048-emmtplv3 287 24 floated float VBD cord-309048-emmtplv3 287 25 on on IN cord-309048-emmtplv3 287 26 top top NN cord-309048-emmtplv3 287 27 of of IN cord-309048-emmtplv3 287 28 the the DT cord-309048-emmtplv3 287 29 structures structure NNS cord-309048-emmtplv3 287 30 ( ( -LRB- cord-309048-emmtplv3 287 31 Steinmetz Steinmetz NNP cord-309048-emmtplv3 287 32 et et NNP cord-309048-emmtplv3 287 33 al al NNP cord-309048-emmtplv3 287 34 . . NNP cord-309048-emmtplv3 287 35 , , , cord-309048-emmtplv3 287 36 2008 2008 CD cord-309048-emmtplv3 287 37 ) ) -RRB- cord-309048-emmtplv3 287 38 . . . cord-309048-emmtplv3 288 1 This this DT cord-309048-emmtplv3 288 2 problem problem NN cord-309048-emmtplv3 288 3 was be VBD cord-309048-emmtplv3 288 4 solved solve VBN cord-309048-emmtplv3 288 5 by by IN cord-309048-emmtplv3 288 6 sequentially sequentially RB cord-309048-emmtplv3 288 7 alternating alternate VBG cord-309048-emmtplv3 288 8 layer layer NN cord-309048-emmtplv3 288 9 - - HYPH cord-309048-emmtplv3 288 10 by by IN cord-309048-emmtplv3 288 11 - - HYPH cord-309048-emmtplv3 288 12 layer layer NN cord-309048-emmtplv3 288 13 application application NN cord-309048-emmtplv3 288 14 of of IN cord-309048-emmtplv3 288 15 two two CD cord-309048-emmtplv3 288 16 differently differently RB cord-309048-emmtplv3 288 17 charged charge VBN cord-309048-emmtplv3 288 18 TMV TMV NNP cord-309048-emmtplv3 288 19 variants variant NNS cord-309048-emmtplv3 288 20 yielding yield VBG cord-309048-emmtplv3 288 21 stable stable JJ cord-309048-emmtplv3 288 22 multilayer multilayer JJ cord-309048-emmtplv3 288 23 films film NNS cord-309048-emmtplv3 288 24 that that WDT cord-309048-emmtplv3 288 25 could could MD cord-309048-emmtplv3 288 26 be be VB cord-309048-emmtplv3 288 27 converted convert VBN cord-309048-emmtplv3 288 28 into into IN cord-309048-emmtplv3 288 29 free free RB cord-309048-emmtplv3 288 30 - - HYPH cord-309048-emmtplv3 288 31 standing stand VBG cord-309048-emmtplv3 288 32 TMV TMV NNP cord-309048-emmtplv3 288 33 membranes membrane NNS cord-309048-emmtplv3 288 34 that that IN cord-309048-emmtplv3 288 35 , , , cord-309048-emmtplv3 288 36 in in IN cord-309048-emmtplv3 288 37 turn turn NN cord-309048-emmtplv3 288 38 , , , cord-309048-emmtplv3 288 39 could could MD cord-309048-emmtplv3 288 40 be be VB cord-309048-emmtplv3 288 41 used use VBN cord-309048-emmtplv3 288 42 as as IN cord-309048-emmtplv3 288 43 tissue tissue NN cord-309048-emmtplv3 288 44 engineering engineering NN cord-309048-emmtplv3 288 45 supports support NNS cord-309048-emmtplv3 288 46 ( ( -LRB- cord-309048-emmtplv3 288 47 Tiu Tiu NNP cord-309048-emmtplv3 288 48 et et FW cord-309048-emmtplv3 288 49 al al NNP cord-309048-emmtplv3 288 50 . . NNP cord-309048-emmtplv3 288 51 , , , cord-309048-emmtplv3 288 52 2017 2017 CD cord-309048-emmtplv3 288 53 ) ) -RRB- cord-309048-emmtplv3 288 54 . . . cord-309048-emmtplv3 289 1 One one CD cord-309048-emmtplv3 289 2 of of IN cord-309048-emmtplv3 289 3 the the DT cord-309048-emmtplv3 289 4 most most RBS cord-309048-emmtplv3 289 5 rapidly rapidly RB cord-309048-emmtplv3 289 6 advancing advance VBG cord-309048-emmtplv3 289 7 applications application NNS cord-309048-emmtplv3 289 8 of of IN cord-309048-emmtplv3 289 9 TMV TMV NNP cord-309048-emmtplv3 289 10 carrier carrier NN cord-309048-emmtplv3 289 11 templates template NNS cord-309048-emmtplv3 289 12 is be VBZ cord-309048-emmtplv3 289 13 the the DT cord-309048-emmtplv3 289 14 preparation preparation NN cord-309048-emmtplv3 289 15 of of IN cord-309048-emmtplv3 289 16 surfaces surface NNS cord-309048-emmtplv3 289 17 that that WDT cord-309048-emmtplv3 289 18 foster foster JJ cord-309048-emmtplv3 289 19 cell cell NN cord-309048-emmtplv3 289 20 attachment attachment NN cord-309048-emmtplv3 289 21 and and CC cord-309048-emmtplv3 289 22 differentiation differentiation NN cord-309048-emmtplv3 289 23 . . . cord-309048-emmtplv3 290 1 TMV TMV NNP cord-309048-emmtplv3 290 2 - - HYPH cord-309048-emmtplv3 290 3 coated coat VBN cord-309048-emmtplv3 290 4 culture culture NN cord-309048-emmtplv3 290 5 supports support NNS cord-309048-emmtplv3 290 6 appear appear VBP cord-309048-emmtplv3 290 7 to to TO cord-309048-emmtplv3 290 8 have have VB cord-309048-emmtplv3 290 9 advantages advantage NNS cord-309048-emmtplv3 290 10 for for IN cord-309048-emmtplv3 290 11 the the DT cord-309048-emmtplv3 290 12 cultivation cultivation NN cord-309048-emmtplv3 290 13 of of IN cord-309048-emmtplv3 290 14 certain certain JJ cord-309048-emmtplv3 290 15 cells cell NNS cord-309048-emmtplv3 290 16 ; ; : cord-309048-emmtplv3 290 17 they -PRON- PRP cord-309048-emmtplv3 290 18 also also RB cord-309048-emmtplv3 290 19 enable enable VBP cord-309048-emmtplv3 290 20 the the DT cord-309048-emmtplv3 290 21 spatially spatially RB cord-309048-emmtplv3 290 22 defined define VBN cord-309048-emmtplv3 290 23 presentation presentation NN cord-309048-emmtplv3 290 24 of of IN cord-309048-emmtplv3 290 25 peptide peptide NN cord-309048-emmtplv3 290 26 ligands ligand NNS cord-309048-emmtplv3 290 27 over over IN cord-309048-emmtplv3 290 28 nanometric nanometric JJ cord-309048-emmtplv3 290 29 distances distance NNS cord-309048-emmtplv3 290 30 . . . cord-309048-emmtplv3 291 1 Applications application NNS cord-309048-emmtplv3 291 2 , , , cord-309048-emmtplv3 291 3 such such JJ cord-309048-emmtplv3 291 4 as as IN cord-309048-emmtplv3 291 5 the the DT cord-309048-emmtplv3 291 6 osteogenesis osteogenesis NN cord-309048-emmtplv3 291 7 of of IN cord-309048-emmtplv3 291 8 bone bone NN cord-309048-emmtplv3 291 9 marrow marrow NN cord-309048-emmtplv3 291 10 stem stem NN cord-309048-emmtplv3 291 11 cells cell NNS cord-309048-emmtplv3 291 12 on on IN cord-309048-emmtplv3 291 13 arginine arginine NN cord-309048-emmtplv3 291 14 - - HYPH cord-309048-emmtplv3 291 15 glycine glycine NN cord-309048-emmtplv3 291 16 - - HYPH cord-309048-emmtplv3 291 17 aspartic aspartic JJ cord-309048-emmtplv3 291 18 acid acid NN cord-309048-emmtplv3 291 19 peptide peptide NN cord-309048-emmtplv3 291 20 - - HYPH cord-309048-emmtplv3 291 21 fashioned fashioned JJ cord-309048-emmtplv3 291 22 TMV TMV NNP cord-309048-emmtplv3 291 23 layers layer NNS cord-309048-emmtplv3 291 24 , , , cord-309048-emmtplv3 291 25 have have VBP cord-309048-emmtplv3 291 26 been be VBN cord-309048-emmtplv3 291 27 extensively extensively RB cord-309048-emmtplv3 291 28 explored explore VBN cord-309048-emmtplv3 291 29 ( ( -LRB- cord-309048-emmtplv3 291 30 Kaur Kaur NNP cord-309048-emmtplv3 291 31 et et NNP cord-309048-emmtplv3 291 32 al al NNP cord-309048-emmtplv3 291 33 . . . cord-309048-emmtplv3 292 1 , , , cord-309048-emmtplv3 292 2 2010 2010 CD cord-309048-emmtplv3 292 3 ; ; : cord-309048-emmtplv3 292 4 Sitasuwan Sitasuwan NNP cord-309048-emmtplv3 292 5 et et NNP cord-309048-emmtplv3 292 6 al al NNP cord-309048-emmtplv3 292 7 . . . cord-309048-emmtplv3 293 1 , , , cord-309048-emmtplv3 293 2 2014 2014 CD cord-309048-emmtplv3 293 3 ) ) -RRB- cord-309048-emmtplv3 293 4 . . . cord-309048-emmtplv3 294 1 Tissue tissue NN cord-309048-emmtplv3 294 2 engineering engineering NN cord-309048-emmtplv3 294 3 approaches approach NNS cord-309048-emmtplv3 294 4 , , , cord-309048-emmtplv3 294 5 making make VBG cord-309048-emmtplv3 294 6 use use NN cord-309048-emmtplv3 294 7 of of IN cord-309048-emmtplv3 294 8 TMV TMV NNP cord-309048-emmtplv3 294 9 as as IN cord-309048-emmtplv3 294 10 a a DT cord-309048-emmtplv3 294 11 carrier carrier NN cord-309048-emmtplv3 294 12 for for IN cord-309048-emmtplv3 294 13 cell cell NN cord-309048-emmtplv3 294 14 - - HYPH cord-309048-emmtplv3 294 15 binding bind VBG cord-309048-emmtplv3 294 16 peptide peptide NN cord-309048-emmtplv3 294 17 motifs motif NNS cord-309048-emmtplv3 294 18 to to TO cord-309048-emmtplv3 294 19 mimic mimic VB cord-309048-emmtplv3 294 20 extracellular extracellular JJ cord-309048-emmtplv3 294 21 matrix matrix NN cord-309048-emmtplv3 294 22 proteins protein NNS cord-309048-emmtplv3 294 23 , , , cord-309048-emmtplv3 294 24 also also RB cord-309048-emmtplv3 294 25 include include VBP cord-309048-emmtplv3 294 26 the the DT cord-309048-emmtplv3 294 27 production production NN cord-309048-emmtplv3 294 28 of of IN cord-309048-emmtplv3 294 29 mats mat NNS cord-309048-emmtplv3 294 30 made make VBN cord-309048-emmtplv3 294 31 from from IN cord-309048-emmtplv3 295 1 electrospun electrospun NNP cord-309048-emmtplv3 295 2 composite composite JJ cord-309048-emmtplv3 295 3 polymer polymer NN cord-309048-emmtplv3 295 4 - - HYPH cord-309048-emmtplv3 295 5 virus virus NN cord-309048-emmtplv3 295 6 nanorod nanorod JJ cord-309048-emmtplv3 295 7 fibers fiber NNS cord-309048-emmtplv3 295 8 for for IN cord-309048-emmtplv3 295 9 improved improved JJ cord-309048-emmtplv3 295 10 handling handling NN cord-309048-emmtplv3 295 11 ( ( -LRB- cord-309048-emmtplv3 295 12 Wu Wu NNP cord-309048-emmtplv3 295 13 et et NNP cord-309048-emmtplv3 295 14 al al NNP cord-309048-emmtplv3 295 15 . . NNP cord-309048-emmtplv3 295 16 , , , cord-309048-emmtplv3 295 17 2011 2011 CD cord-309048-emmtplv3 295 18 ) ) -RRB- cord-309048-emmtplv3 295 19 and and CC cord-309048-emmtplv3 295 20 layouts layout NNS cord-309048-emmtplv3 295 21 combining combine VBG cord-309048-emmtplv3 295 22 3D 3d JJ cord-309048-emmtplv3 295 23 nanostructures nanostructure NNS cord-309048-emmtplv3 295 24 with with IN cord-309048-emmtplv3 295 25 TMV TMV NNP cord-309048-emmtplv3 295 26 - - HYPH cord-309048-emmtplv3 295 27 based base VBN cord-309048-emmtplv3 295 28 effector effector NN cord-309048-emmtplv3 295 29 rods rod NNS cord-309048-emmtplv3 295 30 ( ( -LRB- cord-309048-emmtplv3 295 31 reviewed review VBN cord-309048-emmtplv3 295 32 by by IN cord-309048-emmtplv3 295 33 Wen Wen NNP cord-309048-emmtplv3 295 34 and and CC cord-309048-emmtplv3 295 35 Steinmetz Steinmetz NNP cord-309048-emmtplv3 295 36 , , , cord-309048-emmtplv3 295 37 2016 2016 CD cord-309048-emmtplv3 295 38 ; ; : cord-309048-emmtplv3 295 39 Zhao Zhao NNP cord-309048-emmtplv3 295 40 et et NNP cord-309048-emmtplv3 295 41 al al NNP cord-309048-emmtplv3 295 42 . . NNP cord-309048-emmtplv3 295 43 , , , cord-309048-emmtplv3 295 44 2015 2015 CD cord-309048-emmtplv3 295 45 ; ; : cord-309048-emmtplv3 295 46 Fig Fig NNP cord-309048-emmtplv3 295 47 . . NNP cord-309048-emmtplv3 295 48 2 2 CD cord-309048-emmtplv3 295 49 ) ) -RRB- cord-309048-emmtplv3 295 50 . . . cord-309048-emmtplv3 296 1 FROM from IN cord-309048-emmtplv3 296 2 BOOMERANGS boomerang NNS cord-309048-emmtplv3 296 3 TO to IN cord-309048-emmtplv3 296 4 SPHERES sphere NNS cord-309048-emmtplv3 297 1 7.1 7.1 CD cord-309048-emmtplv3 297 2 Variations variation NNS cord-309048-emmtplv3 297 3 on on IN cord-309048-emmtplv3 297 4 the the DT cord-309048-emmtplv3 297 5 Rod Rod NNP cord-309048-emmtplv3 297 6 - - HYPH cord-309048-emmtplv3 297 7 Shaped Shaped NNP cord-309048-emmtplv3 297 8 Theme theme NN cord-309048-emmtplv3 297 9 Knowledge Knowledge NNP cord-309048-emmtplv3 297 10 of of IN cord-309048-emmtplv3 297 11 the the DT cord-309048-emmtplv3 297 12 mechanism mechanism NN cord-309048-emmtplv3 297 13 of of IN cord-309048-emmtplv3 297 14 assembly assembly NN cord-309048-emmtplv3 297 15 of of IN cord-309048-emmtplv3 297 16 TMV TMV NNP cord-309048-emmtplv3 297 17 particles particle NNS cord-309048-emmtplv3 297 18 has have VBZ cord-309048-emmtplv3 297 19 allowed allow VBN cord-309048-emmtplv3 297 20 the the DT cord-309048-emmtplv3 297 21 generation generation NN cord-309048-emmtplv3 297 22 of of IN cord-309048-emmtplv3 297 23 rod rod NN cord-309048-emmtplv3 297 24 - - HYPH cord-309048-emmtplv3 297 25 shaped shape VBN cord-309048-emmtplv3 297 26 particles particle NNS cord-309048-emmtplv3 297 27 with with IN cord-309048-emmtplv3 297 28 altered altered JJ cord-309048-emmtplv3 297 29 length length NN cord-309048-emmtplv3 297 30 and and CC cord-309048-emmtplv3 297 31 morphology morphology NN cord-309048-emmtplv3 297 32 by by IN cord-309048-emmtplv3 297 33 RNA RNA NNP cord-309048-emmtplv3 297 34 - - HYPH cord-309048-emmtplv3 297 35 guided guide VBN cord-309048-emmtplv3 297 36 assembly assembly NN cord-309048-emmtplv3 297 37 in in IN cord-309048-emmtplv3 297 38 vitro vitro FW cord-309048-emmtplv3 297 39 . . . cord-309048-emmtplv3 298 1 Sets set NNS cord-309048-emmtplv3 298 2 of of IN cord-309048-emmtplv3 298 3 shortened shorten VBN cord-309048-emmtplv3 298 4 TMV TMV NNP cord-309048-emmtplv3 298 5 rods rod NNS cord-309048-emmtplv3 298 6 of of IN cord-309048-emmtplv3 298 7 defined define VBN cord-309048-emmtplv3 298 8 size size NN cord-309048-emmtplv3 298 9 classes class NNS cord-309048-emmtplv3 298 10 were be VBD cord-309048-emmtplv3 298 11 initially initially RB cord-309048-emmtplv3 298 12 produced produce VBN cord-309048-emmtplv3 298 13 to to TO cord-309048-emmtplv3 298 14 evaluate evaluate VB cord-309048-emmtplv3 298 15 their -PRON- PRP$ cord-309048-emmtplv3 298 16 ability ability NN cord-309048-emmtplv3 298 17 to to TO cord-309048-emmtplv3 298 18 stabilize stabilize VB cord-309048-emmtplv3 298 19 and and CC cord-309048-emmtplv3 298 20 regulate regulate VB cord-309048-emmtplv3 298 21 the the DT cord-309048-emmtplv3 298 22 properties property NNS cord-309048-emmtplv3 298 23 of of IN cord-309048-emmtplv3 298 24 ferrofluids ferrofluid NNS cord-309048-emmtplv3 298 25 ( ( -LRB- cord-309048-emmtplv3 298 26 Wu Wu NNP cord-309048-emmtplv3 298 27 et et NNP cord-309048-emmtplv3 298 28 al al NNP cord-309048-emmtplv3 298 29 . . NNP cord-309048-emmtplv3 298 30 , , , cord-309048-emmtplv3 298 31 2010 2010 CD cord-309048-emmtplv3 298 32 ) ) -RRB- cord-309048-emmtplv3 298 33 . . . cord-309048-emmtplv3 299 1 The the DT cord-309048-emmtplv3 299 2 TMV TMV NNP cord-309048-emmtplv3 299 3 rods rod NNS cord-309048-emmtplv3 299 4 enhanced enhance VBN cord-309048-emmtplv3 299 5 and and CC cord-309048-emmtplv3 299 6 fine fine RB cord-309048-emmtplv3 299 7 - - HYPH cord-309048-emmtplv3 299 8 tuned tune VBN cord-309048-emmtplv3 299 9 magnetoviscosity magnetoviscosity NN cord-309048-emmtplv3 299 10 of of IN cord-309048-emmtplv3 299 11 the the DT cord-309048-emmtplv3 299 12 fluids fluid NNS cord-309048-emmtplv3 299 13 to to IN cord-309048-emmtplv3 299 14 an an DT cord-309048-emmtplv3 299 15 unexpected unexpected JJ cord-309048-emmtplv3 299 16 extent extent NN cord-309048-emmtplv3 299 17 and and CC cord-309048-emmtplv3 299 18 suppressed suppress VBN cord-309048-emmtplv3 299 19 shear shear NN cord-309048-emmtplv3 299 20 thinning thinning NN cord-309048-emmtplv3 299 21 in in IN cord-309048-emmtplv3 299 22 a a DT cord-309048-emmtplv3 299 23 length length NN cord-309048-emmtplv3 299 24 - - HYPH cord-309048-emmtplv3 299 25 and and CC cord-309048-emmtplv3 299 26 surface surface NN cord-309048-emmtplv3 299 27 chargedependent chargedependent JJ cord-309048-emmtplv3 299 28 manner manner NN cord-309048-emmtplv3 300 1 ( ( -LRB- cord-309048-emmtplv3 300 2 Fig Fig NNP cord-309048-emmtplv3 300 3 . . NNP cord-309048-emmtplv3 300 4 2 2 CD cord-309048-emmtplv3 300 5 ) ) -RRB- cord-309048-emmtplv3 300 6 . . . cord-309048-emmtplv3 301 1 As as IN cord-309048-emmtplv3 301 2 rheological rheological JJ cord-309048-emmtplv3 301 3 fluids fluid NNS cord-309048-emmtplv3 301 4 are be VBP cord-309048-emmtplv3 301 5 employed employ VBN cord-309048-emmtplv3 301 6 for for IN cord-309048-emmtplv3 301 7 such such JJ cord-309048-emmtplv3 301 8 purposes purpose NNS cord-309048-emmtplv3 301 9 as as IN cord-309048-emmtplv3 301 10 vacuum vacuum NN cord-309048-emmtplv3 301 11 - - HYPH cord-309048-emmtplv3 301 12 tight tight JJ cord-309048-emmtplv3 301 13 sealing sealing NN cord-309048-emmtplv3 301 14 of of IN cord-309048-emmtplv3 301 15 rotating rotate VBG cord-309048-emmtplv3 301 16 shafts shaft NNS cord-309048-emmtplv3 301 17 or or CC cord-309048-emmtplv3 301 18 for for IN cord-309048-emmtplv3 301 19 damping damp VBG cord-309048-emmtplv3 301 20 or or CC cord-309048-emmtplv3 301 21 heat heat NN cord-309048-emmtplv3 301 22 transfer transfer NN cord-309048-emmtplv3 301 23 tasks task NNS cord-309048-emmtplv3 301 24 in in IN cord-309048-emmtplv3 301 25 technical technical JJ cord-309048-emmtplv3 301 26 equipment equipment NN cord-309048-emmtplv3 301 27 , , , cord-309048-emmtplv3 301 28 the the DT cord-309048-emmtplv3 301 29 study study NN cord-309048-emmtplv3 301 30 suggested suggest VBD cord-309048-emmtplv3 301 31 previously previously RB cord-309048-emmtplv3 301 32 unforeseen unforeseen JJ cord-309048-emmtplv3 301 33 applications application NNS cord-309048-emmtplv3 301 34 for for IN cord-309048-emmtplv3 301 35 TMV TMV NNP cord-309048-emmtplv3 301 36 - - HYPH cord-309048-emmtplv3 301 37 based base VBN cord-309048-emmtplv3 301 38 particles particle NNS cord-309048-emmtplv3 301 39 . . . cord-309048-emmtplv3 302 1 TMV TMV NNP cord-309048-emmtplv3 302 2 - - HYPH cord-309048-emmtplv3 302 3 like like JJ cord-309048-emmtplv3 302 4 particles particle NNS cord-309048-emmtplv3 302 5 of of IN cord-309048-emmtplv3 302 6 differing differ VBG cord-309048-emmtplv3 302 7 length length NN cord-309048-emmtplv3 302 8 grown grow VBN cord-309048-emmtplv3 302 9 in in IN cord-309048-emmtplv3 302 10 situ situ NN cord-309048-emmtplv3 302 11 on on IN cord-309048-emmtplv3 302 12 solid solid JJ cord-309048-emmtplv3 302 13 flat flat JJ cord-309048-emmtplv3 302 14 or or CC cord-309048-emmtplv3 302 15 bead bead NN cord-309048-emmtplv3 302 16 supports support NNS cord-309048-emmtplv3 303 1 ( ( -LRB- cord-309048-emmtplv3 303 2 see see VB cord-309048-emmtplv3 303 3 above above RB cord-309048-emmtplv3 303 4 ) ) -RRB- cord-309048-emmtplv3 303 5 yielded yield VBN cord-309048-emmtplv3 303 6 high high JJ cord-309048-emmtplv3 303 7 - - HYPH cord-309048-emmtplv3 303 8 surface surface NN cord-309048-emmtplv3 303 9 density density NN cord-309048-emmtplv3 303 10 arrays array NNS cord-309048-emmtplv3 303 11 of of IN cord-309048-emmtplv3 303 12 carrier carrier NN cord-309048-emmtplv3 303 13 rods rod NNS cord-309048-emmtplv3 303 14 in in IN cord-309048-emmtplv3 303 15 nanobrush nanobrush NNP cord-309048-emmtplv3 303 16 and and CC cord-309048-emmtplv3 303 17 nanostar nanostar NNP cord-309048-emmtplv3 303 18 layouts layout NNS cord-309048-emmtplv3 304 1 ( ( -LRB- cord-309048-emmtplv3 304 2 Azucena Azucena NNP cord-309048-emmtplv3 304 3 et et FW cord-309048-emmtplv3 304 4 al al NNP cord-309048-emmtplv3 304 5 . . . cord-309048-emmtplv3 305 1 , , , cord-309048-emmtplv3 305 2 2012 2012 CD cord-309048-emmtplv3 305 3 ; ; : cord-309048-emmtplv3 305 4 Eber Eber NNP cord-309048-emmtplv3 305 5 et et NNP cord-309048-emmtplv3 305 6 al al NNP cord-309048-emmtplv3 305 7 . . . cord-309048-emmtplv3 306 1 , , , cord-309048-emmtplv3 306 2 2013 2013 CD cord-309048-emmtplv3 306 3 ; ; : cord-309048-emmtplv3 306 4 Mueller Mueller NNP cord-309048-emmtplv3 306 5 et et NNP cord-309048-emmtplv3 306 6 al al NNP cord-309048-emmtplv3 306 7 . . NNP cord-309048-emmtplv3 306 8 , , , cord-309048-emmtplv3 306 9 2011 2011 CD cord-309048-emmtplv3 306 10 ; ; : cord-309048-emmtplv3 307 1 Fig Fig NNP cord-309048-emmtplv3 307 2 . . NNP cord-309048-emmtplv3 307 3 3 3 CD cord-309048-emmtplv3 307 4 ) ) -RRB- cord-309048-emmtplv3 307 5 . . . cord-309048-emmtplv3 308 1 The the DT cord-309048-emmtplv3 308 2 reliable reliable JJ cord-309048-emmtplv3 308 3 in in IN cord-309048-emmtplv3 308 4 vitro vitro FW cord-309048-emmtplv3 308 5 fabrication fabrication NN cord-309048-emmtplv3 308 6 of of IN cord-309048-emmtplv3 308 7 TMV TMV NNP cord-309048-emmtplv3 308 8 - - HYPH cord-309048-emmtplv3 308 9 based base VBN cord-309048-emmtplv3 308 10 nanorods nanorod NNS cord-309048-emmtplv3 308 11 of of IN cord-309048-emmtplv3 308 12 other other JJ cord-309048-emmtplv3 308 13 size size NN cord-309048-emmtplv3 308 14 classes class NNS cord-309048-emmtplv3 309 1 ( ( -LRB- cord-309048-emmtplv3 309 2 Rego Rego NNP cord-309048-emmtplv3 309 3 et et FW cord-309048-emmtplv3 309 4 al al NNP cord-309048-emmtplv3 309 5 . . NNP cord-309048-emmtplv3 309 6 , , , cord-309048-emmtplv3 309 7 2013 2013 CD cord-309048-emmtplv3 309 8 ) ) -RRB- cord-309048-emmtplv3 309 9 has have VBZ cord-309048-emmtplv3 309 10 opened open VBN cord-309048-emmtplv3 309 11 unprecedented unprecedented JJ cord-309048-emmtplv3 309 12 opportunities opportunity NNS cord-309048-emmtplv3 309 13 for for IN cord-309048-emmtplv3 309 14 biomedicine biomedicine NN cord-309048-emmtplv3 309 15 . . . cord-309048-emmtplv3 310 1 Upon upon IN cord-309048-emmtplv3 310 2 delivery delivery NN cord-309048-emmtplv3 310 3 into into IN cord-309048-emmtplv3 310 4 mice mouse NNS cord-309048-emmtplv3 310 5 via via IN cord-309048-emmtplv3 310 6 the the DT cord-309048-emmtplv3 310 7 bloodstream bloodstream NN cord-309048-emmtplv3 310 8 , , , cord-309048-emmtplv3 310 9 fluorescently fluorescently RB cord-309048-emmtplv3 310 10 labeled label VBD cord-309048-emmtplv3 310 11 TMV TMV NNP cord-309048-emmtplv3 310 12 derivatives derivative NNS cord-309048-emmtplv3 310 13 in in IN cord-309048-emmtplv3 310 14 distinct distinct JJ cord-309048-emmtplv3 310 15 length length NN cord-309048-emmtplv3 310 16 classes class NNS cord-309048-emmtplv3 310 17 underwent undergo VBD cord-309048-emmtplv3 310 18 a a DT cord-309048-emmtplv3 310 19 selective selective JJ cord-309048-emmtplv3 310 20 , , , cord-309048-emmtplv3 310 21 aspect aspect NN cord-309048-emmtplv3 310 22 ratio ratio NN cord-309048-emmtplv3 310 23 - - HYPH cord-309048-emmtplv3 310 24 dependent dependent JJ cord-309048-emmtplv3 310 25 uptake uptake NN cord-309048-emmtplv3 310 26 into into IN cord-309048-emmtplv3 310 27 tumor tumor NN cord-309048-emmtplv3 310 28 cells cell NNS cord-309048-emmtplv3 310 29 that that WDT cord-309048-emmtplv3 310 30 could could MD cord-309048-emmtplv3 310 31 be be VB cord-309048-emmtplv3 310 32 modulated modulate VBN cord-309048-emmtplv3 310 33 by by IN cord-309048-emmtplv3 310 34 an an DT cord-309048-emmtplv3 310 35 additional additional JJ cord-309048-emmtplv3 310 36 display display NN cord-309048-emmtplv3 310 37 of of IN cord-309048-emmtplv3 310 38 cell cell NN cord-309048-emmtplv3 310 39 surface surface NN cord-309048-emmtplv3 310 40 receptor receptor NN cord-309048-emmtplv3 310 41 - - HYPH cord-309048-emmtplv3 310 42 targeting target VBG cord-309048-emmtplv3 310 43 arginineglycine arginineglycine NN cord-309048-emmtplv3 310 44 - - HYPH cord-309048-emmtplv3 310 45 aspartic aspartic JJ cord-309048-emmtplv3 310 46 acid acid NN cord-309048-emmtplv3 310 47 ligands ligand NNS cord-309048-emmtplv3 310 48 ( ( -LRB- cord-309048-emmtplv3 310 49 Shukla Shukla NNP cord-309048-emmtplv3 310 50 et et NNP cord-309048-emmtplv3 310 51 al al NNP cord-309048-emmtplv3 310 52 . . NNP cord-309048-emmtplv3 310 53 , , , cord-309048-emmtplv3 310 54 2015 2015 CD cord-309048-emmtplv3 310 55 ) ) -RRB- cord-309048-emmtplv3 310 56 . . . cord-309048-emmtplv3 311 1 The the DT cord-309048-emmtplv3 311 2 concomitant concomitant JJ cord-309048-emmtplv3 311 3 good good JJ cord-309048-emmtplv3 311 4 rate rate NN cord-309048-emmtplv3 311 5 of of IN cord-309048-emmtplv3 311 6 clearance clearance NN cord-309048-emmtplv3 311 7 suggests suggest VBZ cord-309048-emmtplv3 311 8 that that IN cord-309048-emmtplv3 311 9 there there EX cord-309048-emmtplv3 311 10 are be VBP cord-309048-emmtplv3 311 11 good good JJ cord-309048-emmtplv3 311 12 prospects prospect NNS cord-309048-emmtplv3 311 13 for for IN cord-309048-emmtplv3 311 14 TMV TMV NNP cord-309048-emmtplv3 311 15 - - HYPH cord-309048-emmtplv3 311 16 based base VBN cord-309048-emmtplv3 311 17 imaging imaging NN cord-309048-emmtplv3 311 18 and and CC cord-309048-emmtplv3 311 19 therapies therapy NNS cord-309048-emmtplv3 311 20 as as IN cord-309048-emmtplv3 311 21 a a DT cord-309048-emmtplv3 311 22 result result NN cord-309048-emmtplv3 311 23 the the DT cord-309048-emmtplv3 311 24 shape shape NN cord-309048-emmtplv3 311 25 of of IN cord-309048-emmtplv3 311 26 the the DT cord-309048-emmtplv3 311 27 viral viral JJ cord-309048-emmtplv3 311 28 carrier carrier NN cord-309048-emmtplv3 311 29 particle particle NN cord-309048-emmtplv3 311 30 . . . cord-309048-emmtplv3 312 1 These these DT cord-309048-emmtplv3 312 2 results result NNS cord-309048-emmtplv3 312 3 were be VBD cord-309048-emmtplv3 312 4 extended extend VBN cord-309048-emmtplv3 312 5 by by IN cord-309048-emmtplv3 312 6 Liu Liu NNP cord-309048-emmtplv3 312 7 et et NNP cord-309048-emmtplv3 312 8 al al NNP cord-309048-emmtplv3 312 9 . . . cord-309048-emmtplv3 313 1 ( ( -LRB- cord-309048-emmtplv3 313 2 2016 2016 CD cord-309048-emmtplv3 313 3 ) ) -RRB- cord-309048-emmtplv3 314 1 and and CC cord-309048-emmtplv3 314 2 might may MD cord-309048-emmtplv3 314 3 provide provide VB cord-309048-emmtplv3 314 4 the the DT cord-309048-emmtplv3 314 5 basis basis NN cord-309048-emmtplv3 314 6 for for IN cord-309048-emmtplv3 314 7 future future JJ cord-309048-emmtplv3 314 8 tumor tumor NN cord-309048-emmtplv3 314 9 - - HYPH cord-309048-emmtplv3 314 10 targeting target VBG cord-309048-emmtplv3 314 11 treatments treatment NNS cord-309048-emmtplv3 314 12 . . . cord-309048-emmtplv3 315 1 RNA RNA NNP cord-309048-emmtplv3 315 2 - - HYPH cord-309048-emmtplv3 315 3 scaffolded scaffold VBN cord-309048-emmtplv3 315 4 four four CD cord-309048-emmtplv3 315 5 - - HYPH cord-309048-emmtplv3 315 6 turn turn NN cord-309048-emmtplv3 315 7 helices helix NNS cord-309048-emmtplv3 315 8 constitute constitute VBP cord-309048-emmtplv3 315 9 the the DT cord-309048-emmtplv3 315 10 lower low JJR cord-309048-emmtplv3 315 11 size size NN cord-309048-emmtplv3 315 12 limit limit NN cord-309048-emmtplv3 315 13 of of IN cord-309048-emmtplv3 315 14 TMV tmv NN cord-309048-emmtplv3 315 15 - - HYPH cord-309048-emmtplv3 315 16 derived derive VBN cord-309048-emmtplv3 315 17 assemblies assembly NNS cord-309048-emmtplv3 315 18 . . . cord-309048-emmtplv3 316 1 Such such JJ cord-309048-emmtplv3 316 2 nanorings nanoring NNS cord-309048-emmtplv3 316 3 of of IN cord-309048-emmtplv3 316 4 9.2 9.2 CD cord-309048-emmtplv3 316 5 nm nm NN cord-309048-emmtplv3 316 6 thickness thickness NN cord-309048-emmtplv3 316 7 , , , cord-309048-emmtplv3 316 8 stabilized stabilize VBN cord-309048-emmtplv3 316 9 by by IN cord-309048-emmtplv3 316 10 a a DT cord-309048-emmtplv3 316 11 204 204 CD cord-309048-emmtplv3 316 12 nt nt NNP cord-309048-emmtplv3 316 13 OAS OAS NNP cord-309048-emmtplv3 316 14 - - HYPH cord-309048-emmtplv3 316 15 RNA RNA NNP cord-309048-emmtplv3 316 16 and and CC cord-309048-emmtplv3 316 17 containing contain VBG cord-309048-emmtplv3 316 18 blends blend NNS cord-309048-emmtplv3 316 19 of of IN cord-309048-emmtplv3 316 20 distinct distinct JJ cord-309048-emmtplv3 316 21 CP cp NN cord-309048-emmtplv3 316 22 types type NNS cord-309048-emmtplv3 316 23 , , , cord-309048-emmtplv3 316 24 were be VBD cord-309048-emmtplv3 316 25 not not RB cord-309048-emmtplv3 316 26 only only RB cord-309048-emmtplv3 316 27 used use VBN cord-309048-emmtplv3 316 28 for for IN cord-309048-emmtplv3 316 29 attaching attach VBG cord-309048-emmtplv3 316 30 functional functional JJ cord-309048-emmtplv3 316 31 molecules molecule NNS cord-309048-emmtplv3 316 32 to to IN cord-309048-emmtplv3 316 33 technical technical JJ cord-309048-emmtplv3 316 34 substrates substrate NNS cord-309048-emmtplv3 316 35 ( ( -LRB- cord-309048-emmtplv3 316 36 Altintoprak Altintoprak NNPS cord-309048-emmtplv3 316 37 et et NNP cord-309048-emmtplv3 316 38 al al NNP cord-309048-emmtplv3 316 39 . . NNP cord-309048-emmtplv3 316 40 , , , cord-309048-emmtplv3 316 41 2017 2017 CD cord-309048-emmtplv3 316 42 ; ; : cord-309048-emmtplv3 316 43 Fig fig NN cord-309048-emmtplv3 316 44 . . . cord-309048-emmtplv3 316 45 3 3 LS cord-309048-emmtplv3 316 46 ) ) -RRB- cord-309048-emmtplv3 316 47 but but CC cord-309048-emmtplv3 316 48 recently recently RB cord-309048-emmtplv3 316 49 have have VBP cord-309048-emmtplv3 316 50 been be VBN cord-309048-emmtplv3 316 51 employed employ VBN cord-309048-emmtplv3 316 52 as as IN cord-309048-emmtplv3 316 53 " " `` cord-309048-emmtplv3 316 54 pore pore NN cord-309048-emmtplv3 316 55 - - HYPH cord-309048-emmtplv3 316 56 in in IN cord-309048-emmtplv3 316 57 - - HYPH cord-309048-emmtplv3 316 58 pore pore NN cord-309048-emmtplv3 316 59 " " '' cord-309048-emmtplv3 316 60 inlays inlay NNS cord-309048-emmtplv3 316 61 to to TO cord-309048-emmtplv3 316 62 implant implant VB cord-309048-emmtplv3 316 63 their -PRON- PRP$ cord-309048-emmtplv3 316 64 central central JJ cord-309048-emmtplv3 316 65 4 4 CD cord-309048-emmtplv3 316 66 nm nm NNP cord-309048-emmtplv3 316 67 nanopores nanopores NNP cord-309048-emmtplv3 316 68 into into IN cord-309048-emmtplv3 316 69 solid solid JJ cord-309048-emmtplv3 316 70 - - HYPH cord-309048-emmtplv3 316 71 state state NN cord-309048-emmtplv3 316 72 membrane membrane NN cord-309048-emmtplv3 316 73 templates template NNS cord-309048-emmtplv3 317 1 ( ( -LRB- cord-309048-emmtplv3 317 2 Farajollahi Farajollahi NNP cord-309048-emmtplv3 317 3 et et NNP cord-309048-emmtplv3 317 4 al al NNP cord-309048-emmtplv3 317 5 . . NNP cord-309048-emmtplv3 317 6 , , , cord-309048-emmtplv3 317 7 2018 2018 CD cord-309048-emmtplv3 317 8 ) ) -RRB- cord-309048-emmtplv3 317 9 . . . cord-309048-emmtplv3 318 1 As as IN cord-309048-emmtplv3 318 2 described describe VBN cord-309048-emmtplv3 318 3 in in IN cord-309048-emmtplv3 318 4 Section section NN cord-309048-emmtplv3 318 5 5 5 CD cord-309048-emmtplv3 318 6 , , , cord-309048-emmtplv3 318 7 straight straight JJ cord-309048-emmtplv3 318 8 TMV TMV NNP cord-309048-emmtplv3 318 9 - - HYPH cord-309048-emmtplv3 318 10 like like JJ cord-309048-emmtplv3 318 11 particles particle NNS cord-309048-emmtplv3 318 12 are be VBP cord-309048-emmtplv3 318 13 not not RB cord-309048-emmtplv3 318 14 the the DT cord-309048-emmtplv3 318 15 only only JJ cord-309048-emmtplv3 318 16 structures structure NNS cord-309048-emmtplv3 318 17 accessible accessible JJ cord-309048-emmtplv3 318 18 by by IN cord-309048-emmtplv3 318 19 RNA RNA NNP cord-309048-emmtplv3 318 20 - - HYPH cord-309048-emmtplv3 318 21 mediated mediate VBN cord-309048-emmtplv3 318 22 CP CP NNP cord-309048-emmtplv3 318 23 assembly assembly NN cord-309048-emmtplv3 318 24 as as IN cord-309048-emmtplv3 318 25 the the DT cord-309048-emmtplv3 318 26 presence presence NN cord-309048-emmtplv3 318 27 of of IN cord-309048-emmtplv3 318 28 more more JJR cord-309048-emmtplv3 318 29 than than IN cord-309048-emmtplv3 318 30 a a DT cord-309048-emmtplv3 318 31 single single JJ cord-309048-emmtplv3 318 32 OAS OAS NNP cord-309048-emmtplv3 318 33 on on IN cord-309048-emmtplv3 318 34 an an DT cord-309048-emmtplv3 318 35 RNA RNA NNP cord-309048-emmtplv3 318 36 can can MD cord-309048-emmtplv3 318 37 be be VB cord-309048-emmtplv3 318 38 used use VBN cord-309048-emmtplv3 318 39 to to TO cord-309048-emmtplv3 318 40 generate generate VB cord-309048-emmtplv3 318 41 angular angular JJ cord-309048-emmtplv3 318 42 nanostructures nanostructure NNS cord-309048-emmtplv3 318 43 . . . cord-309048-emmtplv3 319 1 These these DT cord-309048-emmtplv3 319 2 branched branch VBN cord-309048-emmtplv3 319 3 and and CC cord-309048-emmtplv3 319 4 kinked kinked JJ cord-309048-emmtplv3 319 5 structures structure NNS cord-309048-emmtplv3 319 6 ( ( -LRB- cord-309048-emmtplv3 319 7 Fig fig NN cord-309048-emmtplv3 319 8 . . . cord-309048-emmtplv3 319 9 3 3 LS cord-309048-emmtplv3 319 10 ) ) -RRB- cord-309048-emmtplv3 319 11 are be VBP cord-309048-emmtplv3 319 12 interesting interesting JJ cord-309048-emmtplv3 319 13 candidates candidate NNS cord-309048-emmtplv3 319 14 for for IN cord-309048-emmtplv3 319 15 subsequent subsequent JJ cord-309048-emmtplv3 319 16 processing processing NN cord-309048-emmtplv3 319 17 into into IN cord-309048-emmtplv3 319 18 bioinorganic bioinorganic NNP cord-309048-emmtplv3 319 19 hybrids hybrid NNS cord-309048-emmtplv3 319 20 with with IN cord-309048-emmtplv3 319 21 unusual unusual JJ cord-309048-emmtplv3 319 22 physical physical JJ cord-309048-emmtplv3 319 23 properties property NNS cord-309048-emmtplv3 319 24 , , , cord-309048-emmtplv3 319 25 and and CC cord-309048-emmtplv3 319 26 supra(bio)molecular supra(bio)molecular JJ cord-309048-emmtplv3 319 27 complexes complex NNS cord-309048-emmtplv3 319 28 for for IN cord-309048-emmtplv3 319 29 multimodal multimodal NN cord-309048-emmtplv3 319 30 delivery delivery NN cord-309048-emmtplv3 319 31 and and CC cord-309048-emmtplv3 319 32 display display NN cord-309048-emmtplv3 319 33 purposes purpose NNS cord-309048-emmtplv3 319 34 . . . cord-309048-emmtplv3 320 1 While while IN cord-309048-emmtplv3 320 2 TMV TMV NNP cord-309048-emmtplv3 320 3 particles particle NNS cord-309048-emmtplv3 320 4 usually usually RB cord-309048-emmtplv3 320 5 have have VBP cord-309048-emmtplv3 320 6 a a DT cord-309048-emmtplv3 320 7 rod rod NN cord-309048-emmtplv3 320 8 - - HYPH cord-309048-emmtplv3 320 9 shaped shape VBN cord-309048-emmtplv3 320 10 helical helical JJ cord-309048-emmtplv3 320 11 structure structure NN cord-309048-emmtplv3 320 12 , , , cord-309048-emmtplv3 320 13 it -PRON- PRP cord-309048-emmtplv3 320 14 is be VBZ cord-309048-emmtplv3 320 15 possible possible JJ cord-309048-emmtplv3 320 16 to to TO cord-309048-emmtplv3 320 17 convert convert VB cord-309048-emmtplv3 320 18 both both DT cord-309048-emmtplv3 320 19 RNA RNA NNP cord-309048-emmtplv3 320 20 - - HYPH cord-309048-emmtplv3 320 21 containing contain VBG cord-309048-emmtplv3 320 22 and and CC cord-309048-emmtplv3 320 23 protein protein NN cord-309048-emmtplv3 320 24 - - HYPH cord-309048-emmtplv3 320 25 only only RB cord-309048-emmtplv3 320 26 rods rod NNS cord-309048-emmtplv3 320 27 to to IN cord-309048-emmtplv3 320 28 a a DT cord-309048-emmtplv3 320 29 spherical spherical JJ cord-309048-emmtplv3 320 30 morphology morphology NN cord-309048-emmtplv3 320 31 by by IN cord-309048-emmtplv3 320 32 heat heat NN cord-309048-emmtplv3 320 33 treatment treatment NN cord-309048-emmtplv3 321 1 ( ( -LRB- cord-309048-emmtplv3 321 2 Atabekov Atabekov NNP cord-309048-emmtplv3 321 3 et et NNP cord-309048-emmtplv3 321 4 al al NNP cord-309048-emmtplv3 321 5 . . NNP cord-309048-emmtplv3 321 6 , , , cord-309048-emmtplv3 321 7 2011 2011 CD cord-309048-emmtplv3 321 8 ; ; : cord-309048-emmtplv3 322 1 Bruckman Bruckman NNP cord-309048-emmtplv3 322 2 et et NNP cord-309048-emmtplv3 322 3 al al NNP cord-309048-emmtplv3 322 4 . . NNP cord-309048-emmtplv3 322 5 , , , cord-309048-emmtplv3 322 6 2015 2015 CD cord-309048-emmtplv3 322 7 ; ; : cord-309048-emmtplv3 322 8 Hart Hart NNP cord-309048-emmtplv3 322 9 , , , cord-309048-emmtplv3 322 10 1956 1956 CD cord-309048-emmtplv3 322 11 ) ) -RRB- cord-309048-emmtplv3 322 12 . . . cord-309048-emmtplv3 323 1 This this DT cord-309048-emmtplv3 323 2 conversion conversion NN cord-309048-emmtplv3 323 3 is be VBZ cord-309048-emmtplv3 323 4 accompanied accompany VBN cord-309048-emmtplv3 323 5 by by IN cord-309048-emmtplv3 323 6 a a DT cord-309048-emmtplv3 323 7 change change NN cord-309048-emmtplv3 323 8 in in IN cord-309048-emmtplv3 323 9 the the DT cord-309048-emmtplv3 323 10 secondary secondary JJ cord-309048-emmtplv3 323 11 structure structure NN cord-309048-emmtplv3 323 12 of of IN cord-309048-emmtplv3 323 13 the the DT cord-309048-emmtplv3 323 14 subunits subunit NNS cord-309048-emmtplv3 323 15 from from IN cord-309048-emmtplv3 323 16 a a DT cord-309048-emmtplv3 323 17 primarily primarily RB cord-309048-emmtplv3 323 18 α α NN cord-309048-emmtplv3 323 19 - - HYPH cord-309048-emmtplv3 323 20 helical helical JJ cord-309048-emmtplv3 323 21 structure structure NN cord-309048-emmtplv3 323 22 to to IN cord-309048-emmtplv3 323 23 one one CD cord-309048-emmtplv3 323 24 that that WDT cord-309048-emmtplv3 323 25 contains contain VBZ cord-309048-emmtplv3 323 26 a a DT cord-309048-emmtplv3 323 27 significant significant JJ cord-309048-emmtplv3 323 28 proportion proportion NN cord-309048-emmtplv3 323 29 of of IN cord-309048-emmtplv3 323 30 β β NN cord-309048-emmtplv3 323 31 - - HYPH cord-309048-emmtplv3 323 32 sheet sheet NN cord-309048-emmtplv3 323 33 ( ( -LRB- cord-309048-emmtplv3 323 34 Dobrov Dobrov NNP cord-309048-emmtplv3 323 35 et et FW cord-309048-emmtplv3 323 36 al al NNP cord-309048-emmtplv3 323 37 . . NNP cord-309048-emmtplv3 323 38 , , , cord-309048-emmtplv3 323 39 2014 2014 CD cord-309048-emmtplv3 323 40 ) ) -RRB- cord-309048-emmtplv3 323 41 . . . cord-309048-emmtplv3 324 1 These these DT cord-309048-emmtplv3 324 2 spherical spherical JJ cord-309048-emmtplv3 324 3 particles particle NNS cord-309048-emmtplv3 324 4 have have VBP cord-309048-emmtplv3 324 5 proved prove VBN cord-309048-emmtplv3 324 6 to to TO cord-309048-emmtplv3 324 7 be be VB cord-309048-emmtplv3 324 8 an an DT cord-309048-emmtplv3 324 9 effective effective JJ cord-309048-emmtplv3 324 10 platform platform NN cord-309048-emmtplv3 324 11 for for IN cord-309048-emmtplv3 324 12 displaying display VBG cord-309048-emmtplv3 324 13 antigens antigen NNS cord-309048-emmtplv3 324 14 ( ( -LRB- cord-309048-emmtplv3 324 15 Karpova Karpova NNP cord-309048-emmtplv3 324 16 et et NNP cord-309048-emmtplv3 324 17 al al NNP cord-309048-emmtplv3 324 18 . . NNP cord-309048-emmtplv3 324 19 , , , cord-309048-emmtplv3 324 20 2012 2012 CD cord-309048-emmtplv3 324 21 ) ) -RRB- cord-309048-emmtplv3 324 22 and and CC cord-309048-emmtplv3 324 23 have have VBP cord-309048-emmtplv3 324 24 been be VBN cord-309048-emmtplv3 324 25 investigated investigate VBN cord-309048-emmtplv3 324 26 as as IN cord-309048-emmtplv3 324 27 delivery delivery NN cord-309048-emmtplv3 324 28 vehicles vehicle NNS cord-309048-emmtplv3 324 29 for for IN cord-309048-emmtplv3 324 30 anticancer anticancer JJ cord-309048-emmtplv3 324 31 drugs drug NNS cord-309048-emmtplv3 324 32 ( ( -LRB- cord-309048-emmtplv3 324 33 Bruckman Bruckman NNP cord-309048-emmtplv3 324 34 et et NNP cord-309048-emmtplv3 324 35 al al NNP cord-309048-emmtplv3 324 36 . . NNP cord-309048-emmtplv3 324 37 , , , cord-309048-emmtplv3 324 38 2016 2016 CD cord-309048-emmtplv3 324 39 ) ) -RRB- cord-309048-emmtplv3 324 40 . . . cord-309048-emmtplv3 325 1 The the DT cord-309048-emmtplv3 325 2 molecular molecular JJ cord-309048-emmtplv3 325 3 organization organization NN cord-309048-emmtplv3 325 4 of of IN cord-309048-emmtplv3 325 5 these these DT cord-309048-emmtplv3 325 6 TMV TMV NNP cord-309048-emmtplv3 325 7 derivatives derivative NNS cord-309048-emmtplv3 325 8 retains retain VBZ cord-309048-emmtplv3 325 9 the the DT cord-309048-emmtplv3 325 10 right right JJ cord-309048-emmtplv3 325 11 - - HYPH cord-309048-emmtplv3 325 12 side side NN cord-309048-emmtplv3 325 13 - - HYPH cord-309048-emmtplv3 325 14 out out RP cord-309048-emmtplv3 325 15 orientation orientation NN cord-309048-emmtplv3 325 16 of of IN cord-309048-emmtplv3 325 17 the the DT cord-309048-emmtplv3 325 18 viral viral JJ cord-309048-emmtplv3 325 19 components component NNS cord-309048-emmtplv3 325 20 with with IN cord-309048-emmtplv3 325 21 CP cp NN cord-309048-emmtplv3 325 22 termini terminus NNS cord-309048-emmtplv3 325 23 accessible accessible JJ cord-309048-emmtplv3 325 24 on on IN cord-309048-emmtplv3 325 25 the the DT cord-309048-emmtplv3 325 26 outer outer JJ cord-309048-emmtplv3 325 27 surface surface NN cord-309048-emmtplv3 325 28 of of IN cord-309048-emmtplv3 325 29 the the DT cord-309048-emmtplv3 325 30 nanospheres nanosphere NNS cord-309048-emmtplv3 325 31 . . . cord-309048-emmtplv3 326 1 As as IN cord-309048-emmtplv3 326 2 we -PRON- PRP cord-309048-emmtplv3 326 3 hope hope VBP cord-309048-emmtplv3 326 4 we -PRON- PRP cord-309048-emmtplv3 326 5 have have VBP cord-309048-emmtplv3 326 6 shown show VBN cord-309048-emmtplv3 326 7 in in IN cord-309048-emmtplv3 326 8 this this DT cord-309048-emmtplv3 326 9 review review NN cord-309048-emmtplv3 326 10 , , , cord-309048-emmtplv3 326 11 the the DT cord-309048-emmtplv3 326 12 study study NN cord-309048-emmtplv3 326 13 of of IN cord-309048-emmtplv3 326 14 TMV TMV NNP cord-309048-emmtplv3 326 15 particles particle NNS cord-309048-emmtplv3 326 16 has have VBZ cord-309048-emmtplv3 326 17 come come VBN cord-309048-emmtplv3 326 18 a a DT cord-309048-emmtplv3 326 19 long long JJ cord-309048-emmtplv3 326 20 way way NN cord-309048-emmtplv3 326 21 since since IN cord-309048-emmtplv3 326 22 the the DT cord-309048-emmtplv3 326 23 virus virus NN cord-309048-emmtplv3 326 24 was be VBD cord-309048-emmtplv3 326 25 first first RB cord-309048-emmtplv3 326 26 described describe VBN cord-309048-emmtplv3 326 27 in in IN cord-309048-emmtplv3 326 28 the the DT cord-309048-emmtplv3 326 29 late late JJ cord-309048-emmtplv3 326 30 19th 19th JJ cord-309048-emmtplv3 326 31 century century NN cord-309048-emmtplv3 326 32 . . . cord-309048-emmtplv3 327 1 In in IN cord-309048-emmtplv3 327 2 some some DT cord-309048-emmtplv3 327 3 ways way NNS cord-309048-emmtplv3 327 4 it -PRON- PRP cord-309048-emmtplv3 327 5 seems seem VBZ cord-309048-emmtplv3 327 6 amazing amazing JJ cord-309048-emmtplv3 327 7 that that IN cord-309048-emmtplv3 327 8 so so RB cord-309048-emmtplv3 327 9 simple simple JJ cord-309048-emmtplv3 327 10 a a DT cord-309048-emmtplv3 327 11 structure structure NN cord-309048-emmtplv3 327 12 , , , cord-309048-emmtplv3 327 13 consisting consist VBG cord-309048-emmtplv3 327 14 of of IN cord-309048-emmtplv3 327 15 multiple multiple JJ cord-309048-emmtplv3 327 16 copies copy NNS cord-309048-emmtplv3 327 17 of of IN cord-309048-emmtplv3 327 18 a a DT cord-309048-emmtplv3 327 19 single single JJ cord-309048-emmtplv3 327 20 type type NN cord-309048-emmtplv3 327 21 of of IN cord-309048-emmtplv3 327 22 protein protein NN cord-309048-emmtplv3 327 23 and and CC cord-309048-emmtplv3 327 24 a a DT cord-309048-emmtplv3 327 25 single single JJ cord-309048-emmtplv3 327 26 molecule molecule NN cord-309048-emmtplv3 327 27 of of IN cord-309048-emmtplv3 327 28 RNA RNA NNP cord-309048-emmtplv3 327 29 , , , cord-309048-emmtplv3 327 30 could could MD cord-309048-emmtplv3 327 31 be be VB cord-309048-emmtplv3 327 32 the the DT cord-309048-emmtplv3 327 33 object object NN cord-309048-emmtplv3 327 34 of of IN cord-309048-emmtplv3 327 35 such such JJ cord-309048-emmtplv3 327 36 intense intense JJ cord-309048-emmtplv3 327 37 study study NN cord-309048-emmtplv3 327 38 for for IN cord-309048-emmtplv3 327 39 over over IN cord-309048-emmtplv3 327 40 100 100 CD cord-309048-emmtplv3 327 41 years year NNS cord-309048-emmtplv3 327 42 . . . cord-309048-emmtplv3 328 1 However however RB cord-309048-emmtplv3 328 2 , , , cord-309048-emmtplv3 328 3 it -PRON- PRP cord-309048-emmtplv3 328 4 is be VBZ cord-309048-emmtplv3 328 5 this this DT cord-309048-emmtplv3 328 6 very very JJ cord-309048-emmtplv3 328 7 simplicity simplicity NN cord-309048-emmtplv3 328 8 that that WDT cord-309048-emmtplv3 328 9 has have VBZ cord-309048-emmtplv3 328 10 made make VBN cord-309048-emmtplv3 328 11 TMV TMV NNP cord-309048-emmtplv3 328 12 such such PDT cord-309048-emmtplv3 328 13 a a DT cord-309048-emmtplv3 328 14 tractable tractable JJ cord-309048-emmtplv3 328 15 system system NN cord-309048-emmtplv3 328 16 both both DT cord-309048-emmtplv3 328 17 for for IN cord-309048-emmtplv3 328 18 fundamental fundamental JJ cord-309048-emmtplv3 328 19 studies study NNS cord-309048-emmtplv3 328 20 and and CC cord-309048-emmtplv3 328 21 , , , cord-309048-emmtplv3 328 22 latterly latterly RB cord-309048-emmtplv3 328 23 , , , cord-309048-emmtplv3 328 24 for for IN cord-309048-emmtplv3 328 25 exploitation exploitation NN cord-309048-emmtplv3 328 26 for for IN cord-309048-emmtplv3 328 27 applications application NNS cord-309048-emmtplv3 328 28 in in IN cord-309048-emmtplv3 328 29 bionanotechnology bionanotechnology NN cord-309048-emmtplv3 328 30 . . . cord-309048-emmtplv3 329 1 Indeed indeed RB cord-309048-emmtplv3 329 2 , , , cord-309048-emmtplv3 329 3 the the DT cord-309048-emmtplv3 329 4 number number NN cord-309048-emmtplv3 329 5 of of IN cord-309048-emmtplv3 329 6 publications publication NNS cord-309048-emmtplv3 329 7 regarding regard VBG cord-309048-emmtplv3 329 8 the the DT cord-309048-emmtplv3 329 9 uses use NNS cord-309048-emmtplv3 329 10 of of IN cord-309048-emmtplv3 329 11 TMV TMV NNP cord-309048-emmtplv3 329 12 particles particle NNS cord-309048-emmtplv3 329 13 continues continue VBZ cord-309048-emmtplv3 329 14 to to TO cord-309048-emmtplv3 329 15 increase increase VB cord-309048-emmtplv3 329 16 rapidly rapidly RB cord-309048-emmtplv3 329 17 , , , cord-309048-emmtplv3 329 18 so so RB cord-309048-emmtplv3 329 19 much much RB cord-309048-emmtplv3 329 20 so so IN cord-309048-emmtplv3 329 21 that that IN cord-309048-emmtplv3 329 22 it -PRON- PRP cord-309048-emmtplv3 329 23 is be VBZ cord-309048-emmtplv3 329 24 difficult difficult JJ cord-309048-emmtplv3 329 25 to to TO cord-309048-emmtplv3 329 26 keep keep VB cord-309048-emmtplv3 329 27 pace pace NN cord-309048-emmtplv3 329 28 with with IN cord-309048-emmtplv3 329 29 all all PDT cord-309048-emmtplv3 329 30 the the DT cord-309048-emmtplv3 329 31 developments development NNS cord-309048-emmtplv3 329 32 and and CC cord-309048-emmtplv3 329 33 certainly certainly RB cord-309048-emmtplv3 329 34 to to TO cord-309048-emmtplv3 329 35 do do VB cord-309048-emmtplv3 329 36 them -PRON- PRP cord-309048-emmtplv3 329 37 all all DT cord-309048-emmtplv3 329 38 justice justice NN cord-309048-emmtplv3 329 39 in in IN cord-309048-emmtplv3 329 40 a a DT cord-309048-emmtplv3 329 41 review review NN cord-309048-emmtplv3 329 42 of of IN cord-309048-emmtplv3 329 43 this this DT cord-309048-emmtplv3 329 44 length length NN cord-309048-emmtplv3 329 45 . . . cord-309048-emmtplv3 330 1 However however RB cord-309048-emmtplv3 330 2 , , , cord-309048-emmtplv3 330 3 we -PRON- PRP cord-309048-emmtplv3 330 4 hope hope VBP cord-309048-emmtplv3 330 5 that that IN cord-309048-emmtplv3 330 6 we -PRON- PRP cord-309048-emmtplv3 330 7 have have VBP cord-309048-emmtplv3 330 8 at at IN cord-309048-emmtplv3 330 9 least least RBS cord-309048-emmtplv3 330 10 given give VBN cord-309048-emmtplv3 330 11 our -PRON- PRP$ cord-309048-emmtplv3 330 12 readers reader NNS cord-309048-emmtplv3 330 13 an an DT cord-309048-emmtplv3 330 14 insight insight NN cord-309048-emmtplv3 330 15 into into IN cord-309048-emmtplv3 330 16 how how WRB cord-309048-emmtplv3 330 17 basic basic JJ cord-309048-emmtplv3 330 18 research research NN cord-309048-emmtplv3 330 19 has have VBZ cord-309048-emmtplv3 330 20 been be VBN cord-309048-emmtplv3 330 21 translated translate VBN cord-309048-emmtplv3 330 22 into into IN cord-309048-emmtplv3 330 23 possible possible JJ cord-309048-emmtplv3 330 24 applications application NNS cord-309048-emmtplv3 330 25 . . . cord-309048-emmtplv3 331 1 ACKNOWLEDGMENTS acknowledgment NNS cord-309048-emmtplv3 331 2 G.P.L. G.P.L. NNP cord-309048-emmtplv3 331 3 is be VBZ cord-309048-emmtplv3 331 4 extremely extremely RB cord-309048-emmtplv3 331 5 grateful grateful JJ cord-309048-emmtplv3 331 6 to to IN cord-309048-emmtplv3 331 7 the the DT cord-309048-emmtplv3 331 8 Fulbright Fulbright NNP cord-309048-emmtplv3 331 9 Commission Commission NNP cord-309048-emmtplv3 331 10 for for IN cord-309048-emmtplv3 331 11 the the DT cord-309048-emmtplv3 331 12 Scholarship scholarship NN cord-309048-emmtplv3 331 13 that that WDT cord-309048-emmtplv3 331 14 enabled enable VBD cord-309048-emmtplv3 331 15 him -PRON- PRP cord-309048-emmtplv3 331 16 to to TO cord-309048-emmtplv3 331 17 spend spend VB cord-309048-emmtplv3 331 18 a a DT cord-309048-emmtplv3 331 19 sabbatical sabbatical JJ cord-309048-emmtplv3 331 20 year year NN cord-309048-emmtplv3 331 21 in in IN cord-309048-emmtplv3 331 22 Prof. Prof. NNP cord-309048-emmtplv3 331 23 Zaitlin Zaitlin NNP cord-309048-emmtplv3 331 24 's 's POS cord-309048-emmtplv3 331 25 laboratory laboratory NN cord-309048-emmtplv3 331 26 at at IN cord-309048-emmtplv3 331 27 Cornell Cornell NNP cord-309048-emmtplv3 331 28 University University NNP cord-309048-emmtplv3 331 29 , , , cord-309048-emmtplv3 331 30 USA USA NNP cord-309048-emmtplv3 331 31 , , , cord-309048-emmtplv3 331 32 between between IN cord-309048-emmtplv3 331 33 1987 1987 CD cord-309048-emmtplv3 331 34 and and CC cord-309048-emmtplv3 331 35 1988 1988 CD cord-309048-emmtplv3 331 36 . . . cord-309048-emmtplv3 332 1 He -PRON- PRP cord-309048-emmtplv3 332 2 also also RB cord-309048-emmtplv3 332 3 acknowledges acknowledge VBZ cord-309048-emmtplv3 332 4 the the DT cord-309048-emmtplv3 332 5 support support NN cord-309048-emmtplv3 332 6 of of IN cord-309048-emmtplv3 332 7 the the DT cord-309048-emmtplv3 332 8 John John NNP cord-309048-emmtplv3 332 9 Innes Innes NNP cord-309048-emmtplv3 332 10 Foundation Foundation NNP cord-309048-emmtplv3 332 11 , , , cord-309048-emmtplv3 332 12 the the DT cord-309048-emmtplv3 332 13 UK UK NNP cord-309048-emmtplv3 332 14 Biotechnology Biotechnology NNP cord-309048-emmtplv3 332 15 and and CC cord-309048-emmtplv3 332 16 Biological Biological NNP cord-309048-emmtplv3 332 17 Sciences Sciences NNPS cord-309048-emmtplv3 332 18 Research Research NNP cord-309048-emmtplv3 332 19 Council Council NNP cord-309048-emmtplv3 332 20 ( ( -LRB- cord-309048-emmtplv3 332 21 BBSRC BBSRC NNP cord-309048-emmtplv3 332 22 ) ) -RRB- cord-309048-emmtplv3 333 1 Institute Institute NNP cord-309048-emmtplv3 333 2 Strategic Strategic NNP cord-309048-emmtplv3 333 3 Programme Programme NNP cord-309048-emmtplv3 333 4 Grant Grant NNP cord-309048-emmtplv3 333 5 " " '' cord-309048-emmtplv3 333 6 Molecules molecule NNS cord-309048-emmtplv3 333 7 from from IN cord-309048-emmtplv3 333 8 Nature Nature NNP cord-309048-emmtplv3 333 9 " " '' cord-309048-emmtplv3 333 10 ( ( -LRB- cord-309048-emmtplv3 333 11 BB BB NNP cord-309048-emmtplv3 333 12 / / SYM cord-309048-emmtplv3 333 13 P012523/1 P012523/1 NNP cord-309048-emmtplv3 333 14 ) ) -RRB- cord-309048-emmtplv3 333 15 and and CC cord-309048-emmtplv3 333 16 Dr. Dr. NNP cord-309048-emmtplv3 333 17 John John NNP cord-309048-emmtplv3 333 18 Steele Steele NNP cord-309048-emmtplv3 333 19 for for IN cord-309048-emmtplv3 333 20 help help NN cord-309048-emmtplv3 333 21 with with IN cord-309048-emmtplv3 333 22 the the DT cord-309048-emmtplv3 333 23 figures figure NNS cord-309048-emmtplv3 333 24 . . . cord-309048-emmtplv3 334 1 C.W. C.W. NNP cord-309048-emmtplv3 334 2 acknowledges acknowledge VBZ cord-309048-emmtplv3 334 3 financial financial JJ cord-309048-emmtplv3 334 4 support support NN cord-309048-emmtplv3 334 5 by by IN cord-309048-emmtplv3 334 6 the the DT cord-309048-emmtplv3 334 7 Carl Carl NNP cord-309048-emmtplv3 334 8 Zeiss Zeiss NNP cord-309048-emmtplv3 334 9 Stiftung Stiftung NNP cord-309048-emmtplv3 334 10 and and CC cord-309048-emmtplv3 334 11 the the DT cord-309048-emmtplv3 334 12 University University NNP cord-309048-emmtplv3 334 13 of of IN cord-309048-emmtplv3 334 14 Stuttgart Stuttgart NNP cord-309048-emmtplv3 334 15 ( ( -LRB- cord-309048-emmtplv3 334 16 Projekthaus Projekthaus NNP cord-309048-emmtplv3 334 17 NanoBioMater NanoBioMater NNP cord-309048-emmtplv3 334 18 ) ) -RRB- cord-309048-emmtplv3 334 19 , , , cord-309048-emmtplv3 334 20 and and CC cord-309048-emmtplv3 334 21 subsidiary subsidiary NN cord-309048-emmtplv3 334 22 funding funding NN cord-309048-emmtplv3 334 23 by by IN cord-309048-emmtplv3 334 24 the the DT cord-309048-emmtplv3 334 25 DFG DFG NNP cord-309048-emmtplv3 334 26 and and CC cord-309048-emmtplv3 334 27 the the DT cord-309048-emmtplv3 334 28 Baden Baden NNP cord-309048-emmtplv3 334 29 - - HYPH cord-309048-emmtplv3 334 30 W€ W€ NNP cord-309048-emmtplv3 334 31 urttemberg urttemberg NNP cord-309048-emmtplv3 334 32 Stiftung Stiftung NNP cord-309048-emmtplv3 334 33 . . . cord-309048-emmtplv3 335 1 Many many JJ cord-309048-emmtplv3 335 2 thanks thank NNS cord-309048-emmtplv3 335 3 also also RB cord-309048-emmtplv3 335 4 to to IN cord-309048-emmtplv3 335 5 Holger Holger NNP cord-309048-emmtplv3 335 6 Jeske Jeske NNP cord-309048-emmtplv3 335 7 for for IN cord-309048-emmtplv3 335 8 inspiring inspiring JJ cord-309048-emmtplv3 335 9 debates debate NNS cord-309048-emmtplv3 335 10 and and CC cord-309048-emmtplv3 335 11 pleasant pleasant JJ cord-309048-emmtplv3 335 12 discussions discussion NNS cord-309048-emmtplv3 335 13 on on IN cord-309048-emmtplv3 335 14 all all DT cord-309048-emmtplv3 335 15 aspects aspect NNS cord-309048-emmtplv3 335 16 of of IN cord-309048-emmtplv3 335 17 molecular molecular JJ cord-309048-emmtplv3 335 18 and and CC cord-309048-emmtplv3 335 19 applied apply VBD cord-309048-emmtplv3 335 20 plant plant NN cord-309048-emmtplv3 335 21 virology virology NN cord-309048-emmtplv3 335 22 . . . cord-309048-emmtplv3 336 1 Peptideequipped Peptideequipped NNP cord-309048-emmtplv3 336 2 tobacco tobacco NN cord-309048-emmtplv3 336 3 mosaic mosaic NN cord-309048-emmtplv3 336 4 virus virus NN cord-309048-emmtplv3 336 5 templates template NNS cord-309048-emmtplv3 336 6 for for IN cord-309048-emmtplv3 336 7 selective selective JJ cord-309048-emmtplv3 336 8 and and CC cord-309048-emmtplv3 336 9 controllable controllable JJ cord-309048-emmtplv3 336 10 biomineral biomineral JJ cord-309048-emmtplv3 336 11 deposition deposition NN cord-309048-emmtplv3 337 1 RNA RNA NNP cord-309048-emmtplv3 337 2 - - HYPH cord-309048-emmtplv3 337 3 stabilized stabilize VBN cord-309048-emmtplv3 337 4 protein protein NN cord-309048-emmtplv3 337 5 nanorings nanoring NNS cord-309048-emmtplv3 337 6 : : : cord-309048-emmtplv3 337 7 high high JJ cord-309048-emmtplv3 337 8 - - HYPH cord-309048-emmtplv3 337 9 precision precision NN cord-309048-emmtplv3 337 10 adapters adapter NNS cord-309048-emmtplv3 337 11 for for IN cord-309048-emmtplv3 337 12 biohybrid biohybrid NNP cord-309048-emmtplv3 337 13 design design NN cord-309048-emmtplv3 337 14 Correlation Correlation NNP cord-309048-emmtplv3 337 15 of of IN cord-309048-emmtplv3 337 16 co co JJ cord-309048-emmtplv3 337 17 - - JJ cord-309048-emmtplv3 337 18 ordinated ordinated JJ cord-309048-emmtplv3 337 19 amino amino NN cord-309048-emmtplv3 337 20 acid acid NN cord-309048-emmtplv3 337 21 substitutions substitution NNS cord-309048-emmtplv3 337 22 with with IN cord-309048-emmtplv3 337 23 function function NN cord-309048-emmtplv3 337 24 in in IN cord-309048-emmtplv3 337 25 viruses virus NNS cord-309048-emmtplv3 337 26 related relate VBN cord-309048-emmtplv3 337 27 to to IN cord-309048-emmtplv3 337 28 tobacco tobacco NN cord-309048-emmtplv3 337 29 mosaic mosaic JJ cord-309048-emmtplv3 337 30 virus virus NN cord-309048-emmtplv3 337 31 Aggregation Aggregation NNP cord-309048-emmtplv3 337 32 of of IN cord-309048-emmtplv3 337 33 TMV TMV NNP cord-309048-emmtplv3 337 34 CP CP NNP cord-309048-emmtplv3 337 35 plays play VBZ cord-309048-emmtplv3 337 36 a a DT cord-309048-emmtplv3 337 37 role role NN cord-309048-emmtplv3 337 38 in in IN cord-309048-emmtplv3 337 39 CP cp NN cord-309048-emmtplv3 337 40 functions function NNS cord-309048-emmtplv3 337 41 and and CC cord-309048-emmtplv3 337 42 in in IN cord-309048-emmtplv3 337 43 coat coat NN cord-309048-emmtplv3 337 44 - - HYPH cord-309048-emmtplv3 337 45 protein protein NN cord-309048-emmtplv3 337 46 mediated mediate VBN cord-309048-emmtplv3 337 47 resistance resistance NN cord-309048-emmtplv3 337 48 Thermal thermal JJ cord-309048-emmtplv3 337 49 transition transition NN cord-309048-emmtplv3 337 50 of of IN cord-309048-emmtplv3 337 51 native native JJ cord-309048-emmtplv3 337 52 tobacco tobacco NN cord-309048-emmtplv3 337 53 mosaic mosaic NNP cord-309048-emmtplv3 337 54 virus virus NN cord-309048-emmtplv3 337 55 and and CC cord-309048-emmtplv3 337 56 RNA RNA NNP cord-309048-emmtplv3 337 57 - - HYPH cord-309048-emmtplv3 337 58 free free JJ cord-309048-emmtplv3 337 59 viral viral JJ cord-309048-emmtplv3 337 60 proteins protein NNS cord-309048-emmtplv3 337 61 into into IN cord-309048-emmtplv3 337 62 spherical spherical JJ cord-309048-emmtplv3 337 63 nanoparticles nanoparticle NNS cord-309048-emmtplv3 338 1 New new JJ cord-309048-emmtplv3 338 2 approaches approach NNS cord-309048-emmtplv3 338 3 for for IN cord-309048-emmtplv3 338 4 bottom bottom NN cord-309048-emmtplv3 338 5 - - HYPH cord-309048-emmtplv3 338 6 up up RP cord-309048-emmtplv3 338 7 assembly assembly NN cord-309048-emmtplv3 338 8 of of IN cord-309048-emmtplv3 338 9 tobacco tobacco NN cord-309048-emmtplv3 338 10 mosaic mosaic NNP cord-309048-emmtplv3 338 11 virus virus NN cord-309048-emmtplv3 338 12 - - HYPH cord-309048-emmtplv3 338 13 derived derive VBN cord-309048-emmtplv3 338 14 nucleoprotein nucleoprotein JJ cord-309048-emmtplv3 338 15 tubes tube NNS cord-309048-emmtplv3 338 16 on on IN cord-309048-emmtplv3 338 17 defined define VBN cord-309048-emmtplv3 338 18 patterns pattern NNS cord-309048-emmtplv3 338 19 on on IN cord-309048-emmtplv3 338 20 silica silica NN cord-309048-emmtplv3 338 21 - - HYPH cord-309048-emmtplv3 338 22 and and CC cord-309048-emmtplv3 338 23 polymerbased polymerbase VBN cord-309048-emmtplv3 338 24 substrates substrate NNS cord-309048-emmtplv3 338 25 Tobacco Tobacco NNP cord-309048-emmtplv3 338 26 mosaic mosaic JJ cord-309048-emmtplv3 338 27 virus virus NN cord-309048-emmtplv3 338 28 as as IN cord-309048-emmtplv3 338 29 enzyme enzyme NN cord-309048-emmtplv3 338 30 nanocarrier nanocarrier NN cord-309048-emmtplv3 338 31 for for IN cord-309048-emmtplv3 338 32 electrochemical electrochemical JJ cord-309048-emmtplv3 338 33 biosensors biosensor NNS cord-309048-emmtplv3 338 34 Coat coat NN cord-309048-emmtplv3 338 35 - - HYPH cord-309048-emmtplv3 338 36 protein protein NN cord-309048-emmtplv3 338 37 - - HYPH cord-309048-emmtplv3 338 38 mediated mediate VBN cord-309048-emmtplv3 338 39 resistance resistance NN cord-309048-emmtplv3 338 40 to to IN cord-309048-emmtplv3 338 41 tobacco tobacco VB cord-309048-emmtplv3 338 42 mosaic mosaic NNP cord-309048-emmtplv3 338 43 virus virus NN cord-309048-emmtplv3 338 44 : : : cord-309048-emmtplv3 338 45 discovery discovery NN cord-309048-emmtplv3 338 46 mechanisms mechanism NNS cord-309048-emmtplv3 338 47 and and CC cord-309048-emmtplv3 338 48 exploitation exploitation NN cord-309048-emmtplv3 338 49 Characterization characterization NN cord-309048-emmtplv3 338 50 and and CC cord-309048-emmtplv3 338 51 in in IN cord-309048-emmtplv3 338 52 vitro vitro FW cord-309048-emmtplv3 338 53 translation translation NN cord-309048-emmtplv3 338 54 of of IN cord-309048-emmtplv3 338 55 the the DT cord-309048-emmtplv3 338 56 RNAs rna NNS cord-309048-emmtplv3 338 57 from from IN cord-309048-emmtplv3 338 58 less less JJR cord-309048-emmtplv3 338 59 - - HYPH cord-309048-emmtplv3 338 60 than than IN cord-309048-emmtplv3 338 61 - - HYPH cord-309048-emmtplv3 338 62 full full JJ cord-309048-emmtplv3 338 63 - - HYPH cord-309048-emmtplv3 338 64 length length NN cord-309048-emmtplv3 338 65 , , , cord-309048-emmtplv3 338 66 virus virus NN cord-309048-emmtplv3 338 67 - - HYPH cord-309048-emmtplv3 338 68 related relate VBN cord-309048-emmtplv3 338 69 , , , cord-309048-emmtplv3 338 70 nucleoprotein nucleoprotein NNP cord-309048-emmtplv3 338 71 rods rod NNS cord-309048-emmtplv3 338 72 present present JJ cord-309048-emmtplv3 338 73 in in IN cord-309048-emmtplv3 338 74 tobacco tobacco NN cord-309048-emmtplv3 338 75 mosaic mosaic NN cord-309048-emmtplv3 338 76 virus virus NN cord-309048-emmtplv3 338 77 preparations preparation NNS cord-309048-emmtplv3 338 78 Concerning concern VBG cord-309048-emmtplv3 338 79 contagium contagium NNP cord-309048-emmtplv3 338 80 vivum vivum NNP cord-309048-emmtplv3 338 81 fluidum fluidum NNP cord-309048-emmtplv3 338 82 as as IN cord-309048-emmtplv3 338 83 a a DT cord-309048-emmtplv3 338 84 cause cause NN cord-309048-emmtplv3 338 85 of of IN cord-309048-emmtplv3 338 86 the the DT cord-309048-emmtplv3 338 87 spot spot NN cord-309048-emmtplv3 338 88 disease disease NN cord-309048-emmtplv3 338 89 of of IN cord-309048-emmtplv3 338 90 tobacco tobacco NN cord-309048-emmtplv3 338 91 leaves leave NNS cord-309048-emmtplv3 338 92 . . . cord-309048-emmtplv3 339 1 English english JJ cord-309048-emmtplv3 339 2 translation translation NN cord-309048-emmtplv3 339 3 Display display NN cord-309048-emmtplv3 339 4 of of IN cord-309048-emmtplv3 339 5 epitopes epitope NNS cord-309048-emmtplv3 339 6 on on IN cord-309048-emmtplv3 339 7 the the DT cord-309048-emmtplv3 339 8 surface surface NN cord-309048-emmtplv3 339 9 of of IN cord-309048-emmtplv3 339 10 tobacco tobacco NN cord-309048-emmtplv3 339 11 mosaic mosaic NN cord-309048-emmtplv3 339 12 virus virus NN cord-309048-emmtplv3 339 13 : : : cord-309048-emmtplv3 339 14 impact impact NN cord-309048-emmtplv3 339 15 of of IN cord-309048-emmtplv3 339 16 charge charge NN cord-309048-emmtplv3 339 17 and and CC cord-309048-emmtplv3 339 18 isoelectric isoelectric JJ cord-309048-emmtplv3 339 19 point point NN cord-309048-emmtplv3 339 20 of of IN cord-309048-emmtplv3 339 21 the the DT cord-309048-emmtplv3 339 22 epitope epitope NN cord-309048-emmtplv3 339 23 on on IN cord-309048-emmtplv3 339 24 virus virus NN cord-309048-emmtplv3 339 25 - - HYPH cord-309048-emmtplv3 339 26 host host NN cord-309048-emmtplv3 339 27 interactions interaction NNS cord-309048-emmtplv3 339 28 Expression expression NN cord-309048-emmtplv3 339 29 of of IN cord-309048-emmtplv3 339 30 tobacco tobacco NN cord-309048-emmtplv3 339 31 mosaic mosaic NNP cord-309048-emmtplv3 339 32 virus virus NN cord-309048-emmtplv3 339 33 coat coat NN cord-309048-emmtplv3 339 34 protein protein NN cord-309048-emmtplv3 339 35 by by IN cord-309048-emmtplv3 339 36 a a DT cord-309048-emmtplv3 339 37 cauliflower cauliflower NN cord-309048-emmtplv3 339 38 mosaic mosaic NN cord-309048-emmtplv3 339 39 virus virus NN cord-309048-emmtplv3 339 40 promoter promoter NN cord-309048-emmtplv3 339 41 in in IN cord-309048-emmtplv3 339 42 plants plant NNS cord-309048-emmtplv3 339 43 transformed transform VBN cord-309048-emmtplv3 339 44 by by IN cord-309048-emmtplv3 339 45 agrobacterium agrobacterium NN cord-309048-emmtplv3 339 46 Refined Refined NNP cord-309048-emmtplv3 339 47 atomic atomic JJ cord-309048-emmtplv3 339 48 model model NN cord-309048-emmtplv3 339 49 of of IN cord-309048-emmtplv3 339 50 the the DT cord-309048-emmtplv3 339 51 four four CD cord-309048-emmtplv3 339 52 - - HYPH cord-309048-emmtplv3 339 53 layer layer NN cord-309048-emmtplv3 339 54 aggregate aggregate NN cord-309048-emmtplv3 339 55 of of IN cord-309048-emmtplv3 339 56 the the DT cord-309048-emmtplv3 339 57 tobacco tobacco NN cord-309048-emmtplv3 339 58 mosaic mosaic NNP cord-309048-emmtplv3 339 59 virus virus NN cord-309048-emmtplv3 339 60 coat coat NN cord-309048-emmtplv3 339 61 protein protein NN cord-309048-emmtplv3 339 62 at at IN cord-309048-emmtplv3 339 63 2.4 2.4 CD cord-309048-emmtplv3 339 64 Å å NN cord-309048-emmtplv3 339 65 resolution resolution NN cord-309048-emmtplv3 339 66 Nanoscale Nanoscale NNP cord-309048-emmtplv3 339 67 science science NN cord-309048-emmtplv3 339 68 and and CC cord-309048-emmtplv3 339 69 technology technology NN cord-309048-emmtplv3 339 70 with with IN cord-309048-emmtplv3 339 71 plant plant NN cord-309048-emmtplv3 339 72 viruses virus NNS cord-309048-emmtplv3 339 73 and and CC cord-309048-emmtplv3 339 74 bacteriophages bacteriophage NNS cord-309048-emmtplv3 339 75 Protein Protein NNP cord-309048-emmtplv3 339 76 disk disk NN cord-309048-emmtplv3 339 77 of of IN cord-309048-emmtplv3 339 78 tobacco tobacco NN cord-309048-emmtplv3 339 79 mosaic mosaic JJ cord-309048-emmtplv3 339 80 virus virus NN cord-309048-emmtplv3 339 81 at at IN cord-309048-emmtplv3 339 82 2.8 2.8 CD cord-309048-emmtplv3 339 83 Å å NN cord-309048-emmtplv3 339 84 resolution resolution NN cord-309048-emmtplv3 339 85 showing show VBG cord-309048-emmtplv3 339 86 the the DT cord-309048-emmtplv3 339 87 interactions interaction NNS cord-309048-emmtplv3 339 88 within within IN cord-309048-emmtplv3 339 89 and and CC cord-309048-emmtplv3 339 90 between between IN cord-309048-emmtplv3 339 91 subunits subunit NNS cord-309048-emmtplv3 339 92 Role role NN cord-309048-emmtplv3 339 93 of of IN cord-309048-emmtplv3 339 94 hexahistidine hexahistidine NN cord-309048-emmtplv3 339 95 in in IN cord-309048-emmtplv3 339 96 directed direct VBN cord-309048-emmtplv3 339 97 nanoassemblies nanoassemblie NNS cord-309048-emmtplv3 339 98 of of IN cord-309048-emmtplv3 339 99 tobacco tobacco NN cord-309048-emmtplv3 339 100 mosaic mosaic NNP cord-309048-emmtplv3 339 101 virus virus NN cord-309048-emmtplv3 339 102 coat coat NN cord-309048-emmtplv3 339 103 protein protein NN cord-309048-emmtplv3 339 104 Nanomanufacturing Nanomanufacturing NNP cord-309048-emmtplv3 339 105 of of IN cord-309048-emmtplv3 339 106 tobacco tobacco NN cord-309048-emmtplv3 339 107 mosaic mosaic NNP cord-309048-emmtplv3 339 108 virus virus NN cord-309048-emmtplv3 339 109 - - HYPH cord-309048-emmtplv3 339 110 based base VBN cord-309048-emmtplv3 339 111 spherical spherical JJ cord-309048-emmtplv3 339 112 biomaterials biomaterial NNS cord-309048-emmtplv3 339 113 using use VBG cord-309048-emmtplv3 339 114 a a DT cord-309048-emmtplv3 339 115 continuous continuous JJ cord-309048-emmtplv3 339 116 flow flow NN cord-309048-emmtplv3 339 117 method method NN cord-309048-emmtplv3 339 118 Tobacco tobacco NN cord-309048-emmtplv3 339 119 mosaic mosaic JJ cord-309048-emmtplv3 339 120 virus virus NN cord-309048-emmtplv3 339 121 - - HYPH cord-309048-emmtplv3 339 122 based base VBN cord-309048-emmtplv3 339 123 protein protein NN cord-309048-emmtplv3 339 124 nanoparticles nanoparticle NNS cord-309048-emmtplv3 339 125 and and CC cord-309048-emmtplv3 339 126 nanorods nanorods NNP cord-309048-emmtplv3 339 127 for for IN cord-309048-emmtplv3 339 128 chemotherapy chemotherapy NN cord-309048-emmtplv3 339 129 delivery delivery NN cord-309048-emmtplv3 339 130 targeting target VBG cord-309048-emmtplv3 339 131 breast breast NN cord-309048-emmtplv3 339 132 cancer cancer NN cord-309048-emmtplv3 340 1 The the DT cord-309048-emmtplv3 340 2 current current JJ cord-309048-emmtplv3 340 3 picture picture NN cord-309048-emmtplv3 340 4 of of IN cord-309048-emmtplv3 340 5 the the DT cord-309048-emmtplv3 340 6 structure structure NN cord-309048-emmtplv3 340 7 and and CC cord-309048-emmtplv3 340 8 assembly assembly NN cord-309048-emmtplv3 340 9 of of IN cord-309048-emmtplv3 340 10 tobacco tobacco NN cord-309048-emmtplv3 340 11 mosaic mosaic NNP cord-309048-emmtplv3 340 12 virus virus NN cord-309048-emmtplv3 340 13 Self self NN cord-309048-emmtplv3 340 14 - - HYPH cord-309048-emmtplv3 340 15 assembly assembly NNP cord-309048-emmtplv3 340 16 of of IN cord-309048-emmtplv3 340 17 tobacco tobacco NN cord-309048-emmtplv3 340 18 mosaic mosaic NNP cord-309048-emmtplv3 340 19 virus virus NN cord-309048-emmtplv3 340 20 : : : cord-309048-emmtplv3 340 21 the the DT cord-309048-emmtplv3 340 22 role role NN cord-309048-emmtplv3 340 23 of of IN cord-309048-emmtplv3 340 24 an an DT cord-309048-emmtplv3 340 25 intermediate intermediate JJ cord-309048-emmtplv3 340 26 aggregate aggregate NN cord-309048-emmtplv3 340 27 in in IN cord-309048-emmtplv3 340 28 generating generate VBG cord-309048-emmtplv3 340 29 both both CC cord-309048-emmtplv3 340 30 specificity specificity NN cord-309048-emmtplv3 340 31 and and CC cord-309048-emmtplv3 340 32 speed speed NN cord-309048-emmtplv3 340 33 Assembly Assembly NNP cord-309048-emmtplv3 340 34 of of IN cord-309048-emmtplv3 340 35 the the DT cord-309048-emmtplv3 340 36 particle particle NN cord-309048-emmtplv3 340 37 of of IN cord-309048-emmtplv3 340 38 tobacco tobacco NN cord-309048-emmtplv3 340 39 mosaic mosaic JJ cord-309048-emmtplv3 340 40 virus virus NN cord-309048-emmtplv3 340 41 from from IN cord-309048-emmtplv3 340 42 RNA RNA NNP cord-309048-emmtplv3 340 43 and and CC cord-309048-emmtplv3 340 44 disks disk NNS cord-309048-emmtplv3 340 45 of of IN cord-309048-emmtplv3 340 46 protein protein NN cord-309048-emmtplv3 340 47 Configuration configuration NN cord-309048-emmtplv3 340 48 of of IN cord-309048-emmtplv3 340 49 tobacco tobacco NN cord-309048-emmtplv3 340 50 mosaic mosaic NNP cord-309048-emmtplv3 340 51 virus virus NN cord-309048-emmtplv3 340 52 RNA RNA NNP cord-309048-emmtplv3 340 53 during during IN cord-309048-emmtplv3 340 54 virus virus NN cord-309048-emmtplv3 340 55 assembly assembly NN cord-309048-emmtplv3 341 1 The the DT cord-309048-emmtplv3 341 2 structure structure NN cord-309048-emmtplv3 341 3 of of IN cord-309048-emmtplv3 341 4 the the DT cord-309048-emmtplv3 341 5 protein protein NN cord-309048-emmtplv3 341 6 disk disk NN cord-309048-emmtplv3 341 7 of of IN cord-309048-emmtplv3 341 8 tobacco tobacco NN cord-309048-emmtplv3 341 9 mosaic mosaic JJ cord-309048-emmtplv3 341 10 virus virus NN cord-309048-emmtplv3 341 11 to to IN cord-309048-emmtplv3 341 12 5 5 CD cord-309048-emmtplv3 341 13 Å å NN cord-309048-emmtplv3 341 14 resolution resolution NN cord-309048-emmtplv3 341 15 Biological Biological NNP cord-309048-emmtplv3 341 16 templates template NNS cord-309048-emmtplv3 341 17 for for IN cord-309048-emmtplv3 341 18 antireflective antireflective NNP cord-309048-emmtplv3 341 19 current current JJ cord-309048-emmtplv3 341 20 collectors collector NNS cord-309048-emmtplv3 341 21 for for IN cord-309048-emmtplv3 341 22 photo photo NN cord-309048-emmtplv3 341 23 - - HYPH cord-309048-emmtplv3 341 24 electrochemical electrochemical JJ cord-309048-emmtplv3 341 25 cell cell NN cord-309048-emmtplv3 341 26 applications application NNS cord-309048-emmtplv3 341 27 Plant Plant NNP cord-309048-emmtplv3 341 28 virus virus NN cord-309048-emmtplv3 341 29 directed direct VBD cord-309048-emmtplv3 341 30 fabrication fabrication NN cord-309048-emmtplv3 341 31 of of IN cord-309048-emmtplv3 341 32 nanoscale nanoscale JJ cord-309048-emmtplv3 341 33 materials material NNS cord-309048-emmtplv3 341 34 and and CC cord-309048-emmtplv3 341 35 devices device NNS cord-309048-emmtplv3 341 36 Plant plant NN cord-309048-emmtplv3 341 37 viruses virus NNS cord-309048-emmtplv3 341 38 and and CC cord-309048-emmtplv3 341 39 bacteriophages bacteriophage NNS cord-309048-emmtplv3 341 40 for for IN cord-309048-emmtplv3 341 41 drug drug NN cord-309048-emmtplv3 341 42 delivery delivery NN cord-309048-emmtplv3 341 43 in in IN cord-309048-emmtplv3 341 44 medicine medicine NN cord-309048-emmtplv3 341 45 and and CC cord-309048-emmtplv3 341 46 biotechnology biotechnology NN cord-309048-emmtplv3 341 47 Tobacco Tobacco NNP cord-309048-emmtplv3 341 48 mosaic mosaic NN cord-309048-emmtplv3 341 49 virus virus NN cord-309048-emmtplv3 341 50 delivery delivery NN cord-309048-emmtplv3 341 51 of of IN cord-309048-emmtplv3 341 52 phenanthriplatin phenanthriplatin NN cord-309048-emmtplv3 341 53 for for IN cord-309048-emmtplv3 341 54 cancer cancer NN cord-309048-emmtplv3 341 55 therapy therapy NN cord-309048-emmtplv3 341 56 Plant Plant NNP cord-309048-emmtplv3 341 57 - - HYPH cord-309048-emmtplv3 341 58 derived derive VBN cord-309048-emmtplv3 341 59 vaccine vaccine NN cord-309048-emmtplv3 341 60 protects protect VBZ cord-309048-emmtplv3 341 61 target target NN cord-309048-emmtplv3 341 62 animals animal NNS cord-309048-emmtplv3 341 63 against against IN cord-309048-emmtplv3 341 64 a a DT cord-309048-emmtplv3 341 65 virus virus NN cord-309048-emmtplv3 341 66 disease disease NN cord-309048-emmtplv3 341 67 cDNA cdna NN cord-309048-emmtplv3 341 68 cloning cloning NN cord-309048-emmtplv3 341 69 of of IN cord-309048-emmtplv3 341 70 the the DT cord-309048-emmtplv3 341 71 complete complete JJ cord-309048-emmtplv3 341 72 genome genome NN cord-309048-emmtplv3 341 73 of of IN cord-309048-emmtplv3 341 74 tobacco tobacco NN cord-309048-emmtplv3 341 75 mosaic mosaic JJ cord-309048-emmtplv3 341 76 virus virus NN cord-309048-emmtplv3 341 77 and and CC cord-309048-emmtplv3 341 78 production production NN cord-309048-emmtplv3 341 79 of of IN cord-309048-emmtplv3 341 80 infectious infectious JJ cord-309048-emmtplv3 341 81 transcripts transcript NNS cord-309048-emmtplv3 341 82 A a DT cord-309048-emmtplv3 341 83 chemoselective chemoselective JJ cord-309048-emmtplv3 341 84 biomolecular biomolecular JJ cord-309048-emmtplv3 341 85 template template NN cord-309048-emmtplv3 341 86 for for IN cord-309048-emmtplv3 341 87 assembling assemble VBG cord-309048-emmtplv3 341 88 diverse diverse JJ cord-309048-emmtplv3 341 89 nanotubular nanotubular JJ cord-309048-emmtplv3 341 90 materials material NNS cord-309048-emmtplv3 341 91 β β NNP cord-309048-emmtplv3 341 92 - - : cord-309048-emmtplv3 341 93 Structure Structure NNP cord-309048-emmtplv3 341 94 of of IN cord-309048-emmtplv3 341 95 the the DT cord-309048-emmtplv3 341 96 coat coat NN cord-309048-emmtplv3 341 97 protein protein NN cord-309048-emmtplv3 341 98 subunits subunit NNS cord-309048-emmtplv3 341 99 in in IN cord-309048-emmtplv3 341 100 spherical spherical JJ cord-309048-emmtplv3 341 101 particles particle NNS cord-309048-emmtplv3 341 102 generated generate VBN cord-309048-emmtplv3 341 103 by by IN cord-309048-emmtplv3 341 104 tobacco tobacco NN cord-309048-emmtplv3 341 105 mosaic mosaic NNP cord-309048-emmtplv3 341 106 virus virus NN cord-309048-emmtplv3 341 107 thermal thermal NNP cord-309048-emmtplv3 341 108 denaturation denaturation NNP cord-309048-emmtplv3 341 109 Analysis Analysis NNP cord-309048-emmtplv3 341 110 of of IN cord-309048-emmtplv3 341 111 the the DT cord-309048-emmtplv3 341 112 aphthovirus aphthovirus NNP cord-309048-emmtplv3 341 113 2A/2B 2a/2b CD cord-309048-emmtplv3 341 114 polyprotein polyprotein NNP cord-309048-emmtplv3 341 115 ' ' `` cord-309048-emmtplv3 341 116 cleavage cleavage NN cord-309048-emmtplv3 341 117 ' ' '' cord-309048-emmtplv3 341 118 mechanism mechanism NN cord-309048-emmtplv3 341 119 indicates indicate VBZ cord-309048-emmtplv3 341 120 not not RB cord-309048-emmtplv3 341 121 a a DT cord-309048-emmtplv3 341 122 proteolytic proteolytic JJ cord-309048-emmtplv3 341 123 reaction reaction NN cord-309048-emmtplv3 341 124 , , , cord-309048-emmtplv3 341 125 but but CC cord-309048-emmtplv3 341 126 a a DT cord-309048-emmtplv3 341 127 novel novel JJ cord-309048-emmtplv3 341 128 translational translational JJ cord-309048-emmtplv3 341 129 effect effect NN cord-309048-emmtplv3 341 130 : : : cord-309048-emmtplv3 341 131 a a DT cord-309048-emmtplv3 341 132 putative putative JJ cord-309048-emmtplv3 341 133 ribosomal ribosomal NN cord-309048-emmtplv3 341 134 ' ' '' cord-309048-emmtplv3 341 135 skip skip NN cord-309048-emmtplv3 341 136 Virus virus NN cord-309048-emmtplv3 341 137 particles particle NNS cord-309048-emmtplv3 341 138 as as IN cord-309048-emmtplv3 341 139 templates template NNS cord-309048-emmtplv3 341 140 for for IN cord-309048-emmtplv3 341 141 materials material NNS cord-309048-emmtplv3 341 142 synthesis synthesis NNP cord-309048-emmtplv3 341 143 Organization Organization NNP cord-309048-emmtplv3 341 144 of of IN cord-309048-emmtplv3 341 145 metallic metallic JJ cord-309048-emmtplv3 341 146 nanoparticles nanoparticle NNS cord-309048-emmtplv3 341 147 using use VBG cord-309048-emmtplv3 341 148 tobacco tobacco NN cord-309048-emmtplv3 341 149 mosaic mosaic NN cord-309048-emmtplv3 341 150 virus virus NN cord-309048-emmtplv3 341 151 templates template VBZ cord-309048-emmtplv3 341 152 States state NNS cord-309048-emmtplv3 341 153 of of IN cord-309048-emmtplv3 341 154 aggregation aggregation NN cord-309048-emmtplv3 341 155 of of IN cord-309048-emmtplv3 341 156 tobacco tobacco NN cord-309048-emmtplv3 341 157 mosaic mosaic NNP cord-309048-emmtplv3 341 158 virus virus NN cord-309048-emmtplv3 341 159 protein protein NN cord-309048-emmtplv3 341 160 Bottom bottom NN cord-309048-emmtplv3 341 161 - - HYPH cord-309048-emmtplv3 341 162 up up RB cord-309048-emmtplv3 341 163 - - HYPH cord-309048-emmtplv3 341 164 assembled assemble VBN cord-309048-emmtplv3 341 165 nanostar nanostar JJ cord-309048-emmtplv3 341 166 colloids colloid NNS cord-309048-emmtplv3 341 167 of of IN cord-309048-emmtplv3 341 168 gold gold NN cord-309048-emmtplv3 341 169 cores core NNS cord-309048-emmtplv3 341 170 and and CC cord-309048-emmtplv3 341 171 tubes tube NNS cord-309048-emmtplv3 341 172 derived derive VBN cord-309048-emmtplv3 341 173 from from IN cord-309048-emmtplv3 341 174 tobacco tobacco NN cord-309048-emmtplv3 341 175 mosaic mosaic NNP cord-309048-emmtplv3 341 176 virus virus NN cord-309048-emmtplv3 341 177 RNA RNA NNP cord-309048-emmtplv3 341 178 - - HYPH cord-309048-emmtplv3 341 179 controlled control VBN cord-309048-emmtplv3 341 180 assembly assembly NN cord-309048-emmtplv3 341 181 of of IN cord-309048-emmtplv3 341 182 tobacco tobacco NN cord-309048-emmtplv3 341 183 mosaic mosaic NNP cord-309048-emmtplv3 341 184 virus virus NN cord-309048-emmtplv3 341 185 - - HYPH cord-309048-emmtplv3 341 186 derived derive VBN cord-309048-emmtplv3 341 187 complex complex JJ cord-309048-emmtplv3 341 188 structures structure NNS cord-309048-emmtplv3 341 189 : : : cord-309048-emmtplv3 341 190 from from IN cord-309048-emmtplv3 341 191 nanoboomerangs nanoboomerang NNS cord-309048-emmtplv3 341 192 to to IN cord-309048-emmtplv3 341 193 tetrapods tetrapod NNS cord-309048-emmtplv3 341 194 Tailoring tailor VBG cord-309048-emmtplv3 341 195 the the DT cord-309048-emmtplv3 341 196 surface surface NN cord-309048-emmtplv3 341 197 properties property NNS cord-309048-emmtplv3 341 198 of of IN cord-309048-emmtplv3 341 199 tobacco tobacco NN cord-309048-emmtplv3 341 200 mosaic mosaic NN cord-309048-emmtplv3 341 201 virions virion NNS cord-309048-emmtplv3 341 202 by by IN cord-309048-emmtplv3 341 203 the the DT cord-309048-emmtplv3 341 204 integration integration NN cord-309048-emmtplv3 341 205 of of IN cord-309048-emmtplv3 341 206 bacterially bacterially RB cord-309048-emmtplv3 341 207 expressed express VBN cord-309048-emmtplv3 341 208 mutant mutant JJ cord-309048-emmtplv3 341 209 coat coat NN cord-309048-emmtplv3 341 210 protein protein NNP cord-309048-emmtplv3 341 211 Tobacco Tobacco NNP cord-309048-emmtplv3 341 212 mosaic mosaic JJ cord-309048-emmtplv3 341 213 virus virus NN cord-309048-emmtplv3 341 214 : : : cord-309048-emmtplv3 341 215 a a DT cord-309048-emmtplv3 341 216 biological biological JJ cord-309048-emmtplv3 341 217 building building NN cord-309048-emmtplv3 341 218 block block NN cord-309048-emmtplv3 341 219 for for IN cord-309048-emmtplv3 341 220 micro micro NNP cord-309048-emmtplv3 341 221 / / SYM cord-309048-emmtplv3 341 222 nano nano NNP cord-309048-emmtplv3 341 223 / / SYM cord-309048-emmtplv3 341 224 biosystems biosystems NNP cord-309048-emmtplv3 341 225 Electrochemically Electrochemically NNP cord-309048-emmtplv3 341 226 - - HYPH cord-309048-emmtplv3 341 227 driven drive VBN cord-309048-emmtplv3 341 228 insertion insertion NN cord-309048-emmtplv3 341 229 of of IN cord-309048-emmtplv3 341 230 biological biological JJ cord-309048-emmtplv3 341 231 nanodiscs nanodiscs NN cord-309048-emmtplv3 341 232 into into IN cord-309048-emmtplv3 341 233 solid solid JJ cord-309048-emmtplv3 341 234 state state NN cord-309048-emmtplv3 341 235 membrane membrane NN cord-309048-emmtplv3 341 236 pores pore NNS cord-309048-emmtplv3 341 237 as as IN cord-309048-emmtplv3 341 238 a a DT cord-309048-emmtplv3 341 239 basis basis NN cord-309048-emmtplv3 341 240 for for IN cord-309048-emmtplv3 341 241 " " `` cord-309048-emmtplv3 341 242 pore pore NN cord-309048-emmtplv3 341 243 - - HYPH cord-309048-emmtplv3 341 244 in in IN cord-309048-emmtplv3 341 245 - - HYPH cord-309048-emmtplv3 341 246 pore pore NN cord-309048-emmtplv3 341 247 Stable stable JJ cord-309048-emmtplv3 341 248 disk disk NN cord-309048-emmtplv3 341 249 assemblies assembly NNS cord-309048-emmtplv3 341 250 of of IN cord-309048-emmtplv3 341 251 a a DT cord-309048-emmtplv3 341 252 tobacco tobacco NN cord-309048-emmtplv3 341 253 mosaic mosaic NN cord-309048-emmtplv3 341 254 virus virus NN cord-309048-emmtplv3 341 255 mutant mutant JJ cord-309048-emmtplv3 341 256 as as IN cord-309048-emmtplv3 341 257 nanoscale nanoscale JJ cord-309048-emmtplv3 341 258 scaffolds scaffold NNS cord-309048-emmtplv3 341 259 for for IN cord-309048-emmtplv3 341 260 applications application NNS cord-309048-emmtplv3 341 261 in in IN cord-309048-emmtplv3 341 262 drug drug NN cord-309048-emmtplv3 341 263 delivery delivery NN cord-309048-emmtplv3 341 264 Plant Plant NNP cord-309048-emmtplv3 341 265 virus virus NN cord-309048-emmtplv3 341 266 expressing express VBG cord-309048-emmtplv3 341 267 hybrid hybrid JJ cord-309048-emmtplv3 341 268 coat coat NN cord-309048-emmtplv3 341 269 protein protein NN cord-309048-emmtplv3 341 270 with with IN cord-309048-emmtplv3 341 271 added add VBN cord-309048-emmtplv3 341 272 murine murine JJ cord-309048-emmtplv3 341 273 epitope epitope NN cord-309048-emmtplv3 341 274 elicits elicit VBZ cord-309048-emmtplv3 341 275 autoantibody autoantibody NNP cord-309048-emmtplv3 341 276 response response NN cord-309048-emmtplv3 341 277 Tobacco Tobacco NNP cord-309048-emmtplv3 341 278 mosaic mosaic JJ cord-309048-emmtplv3 341 279 virus virus NN cord-309048-emmtplv3 341 280 liquid liquid NN cord-309048-emmtplv3 341 281 crystals crystal NNS cord-309048-emmtplv3 341 282 as as IN cord-309048-emmtplv3 341 283 templates template NNS cord-309048-emmtplv3 341 284 for for IN cord-309048-emmtplv3 341 285 the the DT cord-309048-emmtplv3 341 286 interior interior JJ cord-309048-emmtplv3 341 287 design design NN cord-309048-emmtplv3 341 288 of of IN cord-309048-emmtplv3 341 289 silica silica NN cord-309048-emmtplv3 341 290 mesophases mesophase NNS cord-309048-emmtplv3 341 291 and and CC cord-309048-emmtplv3 341 292 nanoparticles nanoparticle NNS cord-309048-emmtplv3 341 293 Reconstitution Reconstitution NNP cord-309048-emmtplv3 341 294 of of IN cord-309048-emmtplv3 341 295 active active JJ cord-309048-emmtplv3 341 296 tobacco tobacco NN cord-309048-emmtplv3 341 297 mosaic mosaic NN cord-309048-emmtplv3 341 298 virus virus NN cord-309048-emmtplv3 341 299 from from IN cord-309048-emmtplv3 341 300 its -PRON- PRP$ cord-309048-emmtplv3 341 301 inactive inactive JJ cord-309048-emmtplv3 341 302 protein protein NN cord-309048-emmtplv3 341 303 and and CC cord-309048-emmtplv3 341 304 nucleic nucleic JJ cord-309048-emmtplv3 341 305 acid acid NN cord-309048-emmtplv3 341 306 components component NNS cord-309048-emmtplv3 341 307 Tobacco Tobacco NNP cord-309048-emmtplv3 341 308 mosaic mosaic JJ cord-309048-emmtplv3 341 309 virus virus NN cord-309048-emmtplv3 341 310 - - HYPH cord-309048-emmtplv3 341 311 delivered deliver VBN cord-309048-emmtplv3 341 312 cisplatin cisplatin NN cord-309048-emmtplv3 341 313 restores restore VBZ cord-309048-emmtplv3 341 314 efficacy efficacy NN cord-309048-emmtplv3 341 315 in in IN cord-309048-emmtplv3 341 316 platinum platinum NN cord-309048-emmtplv3 341 317 - - HYPH cord-309048-emmtplv3 341 318 resistant resistant JJ cord-309048-emmtplv3 341 319 ovarian ovarian JJ cord-309048-emmtplv3 341 320 cancer cancer NN cord-309048-emmtplv3 341 321 cells cell NNS cord-309048-emmtplv3 341 322 Structure Structure NNP cord-309048-emmtplv3 341 323 of of IN cord-309048-emmtplv3 341 324 tobacco tobacco NN cord-309048-emmtplv3 341 325 mosaic mosaic NNP cord-309048-emmtplv3 341 326 virus virus NN cord-309048-emmtplv3 341 327 : : : cord-309048-emmtplv3 341 328 location location NN cord-309048-emmtplv3 341 329 of of IN cord-309048-emmtplv3 341 330 the the DT cord-309048-emmtplv3 341 331 ribonucleic ribonucleic JJ cord-309048-emmtplv3 341 332 acid acid NN cord-309048-emmtplv3 341 333 in in IN cord-309048-emmtplv3 341 334 the the DT cord-309048-emmtplv3 341 335 tobacco tobacco NN cord-309048-emmtplv3 341 336 mosaic mosaic NN cord-309048-emmtplv3 341 337 virus virus NN cord-309048-emmtplv3 341 338 particle particle NN cord-309048-emmtplv3 341 339 Targeting target VBG cord-309048-emmtplv3 341 340 cancer cancer NN cord-309048-emmtplv3 341 341 with with IN cord-309048-emmtplv3 341 342 ' ' `` cord-309048-emmtplv3 341 343 smart smart JJ cord-309048-emmtplv3 341 344 bombs bomb NNS cord-309048-emmtplv3 341 345 ' ' '' cord-309048-emmtplv3 341 346 : : : cord-309048-emmtplv3 341 347 equipping equip VBG cord-309048-emmtplv3 341 348 plant plant NN cord-309048-emmtplv3 341 349 virus virus NN cord-309048-emmtplv3 341 350 nanoparticles nanoparticle VBZ cord-309048-emmtplv3 341 351 for for IN cord-309048-emmtplv3 341 352 a a DT cord-309048-emmtplv3 341 353 ' ' `` cord-309048-emmtplv3 341 354 seek seek VB cord-309048-emmtplv3 341 355 and and CC cord-309048-emmtplv3 341 356 destroy destroy VB cord-309048-emmtplv3 341 357 ' ' '' cord-309048-emmtplv3 341 358 mission mission NN cord-309048-emmtplv3 341 359 Trastuzumab Trastuzumab NNP cord-309048-emmtplv3 341 360 - - HYPH cord-309048-emmtplv3 341 361 binding bind VBG cord-309048-emmtplv3 341 362 peptide peptide NN cord-309048-emmtplv3 341 363 display display NN cord-309048-emmtplv3 341 364 by by IN cord-309048-emmtplv3 341 365 tobacco tobacco NN cord-309048-emmtplv3 341 366 mosaic mosaic NN cord-309048-emmtplv3 341 367 virus virus NN cord-309048-emmtplv3 341 368 Seeing see VBG cord-309048-emmtplv3 341 369 tobacco tobacco NN cord-309048-emmtplv3 341 370 mosaic mosaic JJ cord-309048-emmtplv3 341 371 virus virus NN cord-309048-emmtplv3 341 372 through through IN cord-309048-emmtplv3 341 373 direct direct JJ cord-309048-emmtplv3 341 374 electron electron NN cord-309048-emmtplv3 341 375 detectors detector NNS cord-309048-emmtplv3 342 1 The the DT cord-309048-emmtplv3 342 2 5 5 CD cord-309048-emmtplv3 342 3 0 0 CD cord-309048-emmtplv3 342 4 -leader -leader NN cord-309048-emmtplv3 342 5 sequence sequence NN cord-309048-emmtplv3 342 6 of of IN cord-309048-emmtplv3 342 7 tobacco tobacco NN cord-309048-emmtplv3 342 8 mosaic mosaic NNP cord-309048-emmtplv3 342 9 virus virus NN cord-309048-emmtplv3 342 10 RNA RNA NNP cord-309048-emmtplv3 342 11 enhances enhance VBZ cord-309048-emmtplv3 342 12 the the DT cord-309048-emmtplv3 342 13 expression expression NN cord-309048-emmtplv3 342 14 of of IN cord-309048-emmtplv3 342 15 foreign foreign JJ cord-309048-emmtplv3 342 16 gene gene NN cord-309048-emmtplv3 342 17 transcripts transcript NNS cord-309048-emmtplv3 342 18 in in IN cord-309048-emmtplv3 342 19 vitro vitro FW cord-309048-emmtplv3 342 20 and and CC cord-309048-emmtplv3 342 21 in in IN cord-309048-emmtplv3 342 22 vivo vivo NN cord-309048-emmtplv3 343 1 In in IN cord-309048-emmtplv3 343 2 vivo vivo NN cord-309048-emmtplv3 343 3 uncoating uncoating NN cord-309048-emmtplv3 343 4 and and CC cord-309048-emmtplv3 343 5 efficient efficient JJ cord-309048-emmtplv3 343 6 expression expression NN cord-309048-emmtplv3 343 7 of of IN cord-309048-emmtplv3 343 8 foreign foreign NN cord-309048-emmtplv3 343 9 mRNAs mRNAs NNPS cord-309048-emmtplv3 343 10 packaged package VBN cord-309048-emmtplv3 343 11 in in IN cord-309048-emmtplv3 343 12 TMV TMV NNP cord-309048-emmtplv3 343 13 - - HYPH cord-309048-emmtplv3 343 14 like like JJ cord-309048-emmtplv3 343 15 particles particle NNS cord-309048-emmtplv3 344 1 The the DT cord-309048-emmtplv3 344 2 effect effect NN cord-309048-emmtplv3 344 3 of of IN cord-309048-emmtplv3 344 4 multiple multiple JJ cord-309048-emmtplv3 344 5 dispersed disperse VBN cord-309048-emmtplv3 344 6 copies copy NNS cord-309048-emmtplv3 344 7 of of IN cord-309048-emmtplv3 344 8 the the DT cord-309048-emmtplv3 344 9 origin origin NN cord-309048-emmtplv3 344 10 - - HYPH cord-309048-emmtplv3 344 11 of of IN cord-309048-emmtplv3 344 12 - - HYPH cord-309048-emmtplv3 344 13 assembly assembly NN cord-309048-emmtplv3 344 14 sequence sequence NN cord-309048-emmtplv3 344 15 from from IN cord-309048-emmtplv3 344 16 TMV TMV NNP cord-309048-emmtplv3 344 17 RNA RNA NNP cord-309048-emmtplv3 344 18 on on IN cord-309048-emmtplv3 344 19 the the DT cord-309048-emmtplv3 344 20 morphology morphology NN cord-309048-emmtplv3 344 21 of of IN cord-309048-emmtplv3 344 22 pseudovirus pseudovirus NNP cord-309048-emmtplv3 344 23 particles particle NNS cord-309048-emmtplv3 344 24 assembled assemble VBN cord-309048-emmtplv3 344 25 in in IN cord-309048-emmtplv3 344 26 vitro vitro FW cord-309048-emmtplv3 344 27 TMV TMV NNP cord-309048-emmtplv3 344 28 nanorods nanorods NNP cord-309048-emmtplv3 344 29 with with IN cord-309048-emmtplv3 344 30 programmed program VBN cord-309048-emmtplv3 344 31 longitudinal longitudinal JJ cord-309048-emmtplv3 344 32 domains domain NNS cord-309048-emmtplv3 344 33 of of IN cord-309048-emmtplv3 344 34 differently differently RB cord-309048-emmtplv3 344 35 addressable addressable JJ cord-309048-emmtplv3 344 36 coat coat NN cord-309048-emmtplv3 344 37 proteins protein NNS cord-309048-emmtplv3 344 38 Nucleotide nucleotide JJ cord-309048-emmtplv3 344 39 sequence sequence NN cord-309048-emmtplv3 344 40 of of IN cord-309048-emmtplv3 344 41 tobacco tobacco NN cord-309048-emmtplv3 344 42 mosaic mosaic NN cord-309048-emmtplv3 344 43 virus virus NN cord-309048-emmtplv3 344 44 RNA RNA NNP cord-309048-emmtplv3 344 45 Plants Plants NNP cord-309048-emmtplv3 344 46 transformed transform VBN cord-309048-emmtplv3 344 47 with with IN cord-309048-emmtplv3 344 48 a a DT cord-309048-emmtplv3 344 49 tobacco tobacco NN cord-309048-emmtplv3 344 50 mosaic mosaic NN cord-309048-emmtplv3 344 51 virus virus NN cord-309048-emmtplv3 344 52 nonstructural nonstructural JJ cord-309048-emmtplv3 344 53 gene gene NN cord-309048-emmtplv3 344 54 sequence sequence NN cord-309048-emmtplv3 344 55 are be VBP cord-309048-emmtplv3 344 56 resistant resistant JJ cord-309048-emmtplv3 344 57 to to IN cord-309048-emmtplv3 344 58 the the DT cord-309048-emmtplv3 344 59 virus virus NN cord-309048-emmtplv3 345 1 A a DT cord-309048-emmtplv3 345 2 new new JJ cord-309048-emmtplv3 345 3 tobacco tobacco NN cord-309048-emmtplv3 345 4 mosaic mosaic NN cord-309048-emmtplv3 345 5 virus virus NN cord-309048-emmtplv3 345 6 vector vector NN cord-309048-emmtplv3 345 7 and and CC cord-309048-emmtplv3 345 8 its -PRON- PRP$ cord-309048-emmtplv3 345 9 use use NN cord-309048-emmtplv3 345 10 for for IN cord-309048-emmtplv3 345 11 the the DT cord-309048-emmtplv3 345 12 systemic systemic JJ cord-309048-emmtplv3 345 13 production production NN cord-309048-emmtplv3 345 14 of of IN cord-309048-emmtplv3 345 15 angiotensin angiotensin NN cord-309048-emmtplv3 345 16 - - HYPH cord-309048-emmtplv3 345 17 I i NN cord-309048-emmtplv3 345 18 - - HYPH cord-309048-emmtplv3 345 19 converting convert VBG cord-309048-emmtplv3 345 20 enzyme enzyme NN cord-309048-emmtplv3 345 21 inhibitor inhibitor NN cord-309048-emmtplv3 345 22 in in IN cord-309048-emmtplv3 345 23 transgenic transgenic JJ cord-309048-emmtplv3 345 24 tobacco tobacco NN cord-309048-emmtplv3 345 25 and and CC cord-309048-emmtplv3 345 26 tomato tomato NN cord-309048-emmtplv3 345 27 Morphological morphological JJ cord-309048-emmtplv3 345 28 changes change NNS cord-309048-emmtplv3 345 29 accompanying accompany VBG cord-309048-emmtplv3 345 30 thermal thermal JJ cord-309048-emmtplv3 345 31 denaturation denaturation NN cord-309048-emmtplv3 345 32 of of IN cord-309048-emmtplv3 345 33 tobacco tobacco NN cord-309048-emmtplv3 345 34 mosaic mosaic NNP cord-309048-emmtplv3 345 35 virus virus NN cord-309048-emmtplv3 345 36 Development Development NNP cord-309048-emmtplv3 345 37 of of IN cord-309048-emmtplv3 345 38 a a DT cord-309048-emmtplv3 345 39 genetically genetically RB cord-309048-emmtplv3 345 40 engineered engineer VBN cord-309048-emmtplv3 345 41 , , , cord-309048-emmtplv3 345 42 candidate candidate NN cord-309048-emmtplv3 345 43 polio polio NN cord-309048-emmtplv3 345 44 vaccine vaccine NN cord-309048-emmtplv3 345 45 employing employ VBG cord-309048-emmtplv3 345 46 the the DT cord-309048-emmtplv3 345 47 self self NN cord-309048-emmtplv3 345 48 - - HYPH cord-309048-emmtplv3 345 49 assembling assemble VBG cord-309048-emmtplv3 345 50 properties property NNS cord-309048-emmtplv3 345 51 of of IN cord-309048-emmtplv3 345 52 the the DT cord-309048-emmtplv3 345 53 tobacco tobacco NN cord-309048-emmtplv3 345 54 mosaic mosaic NNP cord-309048-emmtplv3 345 55 virus virus NN cord-309048-emmtplv3 345 56 coat coat NN cord-309048-emmtplv3 345 57 protein protein NN cord-309048-emmtplv3 345 58 Messenger Messenger NNP cord-309048-emmtplv3 345 59 RNA RNA NNP cord-309048-emmtplv3 345 60 for for IN cord-309048-emmtplv3 345 61 the the DT cord-309048-emmtplv3 345 62 coat coat NN cord-309048-emmtplv3 345 63 protein protein NN cord-309048-emmtplv3 345 64 of of IN cord-309048-emmtplv3 345 65 tobacco tobacco NN cord-309048-emmtplv3 345 66 mosaic mosaic NNP cord-309048-emmtplv3 345 67 virus virus NN cord-309048-emmtplv3 345 68 Expression expression NN cord-309048-emmtplv3 345 69 of of IN cord-309048-emmtplv3 345 70 tobacco tobacco NN cord-309048-emmtplv3 345 71 mosaic mosaic NNP cord-309048-emmtplv3 345 72 virus virus NN cord-309048-emmtplv3 345 73 coat coat NN cord-309048-emmtplv3 345 74 protein protein NN cord-309048-emmtplv3 345 75 and and CC cord-309048-emmtplv3 345 76 assembly assembly NN cord-309048-emmtplv3 345 77 of of IN cord-309048-emmtplv3 345 78 pseudovirus pseudovirus NNP cord-309048-emmtplv3 345 79 particles particle NNS cord-309048-emmtplv3 345 80 in in IN cord-309048-emmtplv3 345 81 Escherichia Escherichia NNP cord-309048-emmtplv3 345 82 coli coli NNS cord-309048-emmtplv3 346 1 A a DT cord-309048-emmtplv3 346 2 modified modify VBN cord-309048-emmtplv3 346 3 TMV tmv NN cord-309048-emmtplv3 346 4 - - HYPH cord-309048-emmtplv3 346 5 based base VBN cord-309048-emmtplv3 346 6 vector vector NN cord-309048-emmtplv3 346 7 facilitates facilitate VBZ cord-309048-emmtplv3 346 8 the the DT cord-309048-emmtplv3 346 9 expression expression NN cord-309048-emmtplv3 346 10 of of IN cord-309048-emmtplv3 346 11 longer long JJR cord-309048-emmtplv3 346 12 foreign foreign JJ cord-309048-emmtplv3 346 13 epitopes epitope NNS cord-309048-emmtplv3 346 14 in in IN cord-309048-emmtplv3 346 15 tobacco tobacco NN cord-309048-emmtplv3 346 16 Direct direct JJ cord-309048-emmtplv3 346 17 recovery recovery NN cord-309048-emmtplv3 346 18 of of IN cord-309048-emmtplv3 346 19 in in FW cord-309048-emmtplv3 346 20 vitro vitro FW cord-309048-emmtplv3 346 21 transcripts transcript NNS cord-309048-emmtplv3 346 22 in in IN cord-309048-emmtplv3 346 23 a a DT cord-309048-emmtplv3 346 24 protected protect VBN cord-309048-emmtplv3 346 25 form form NN cord-309048-emmtplv3 346 26 suitable suitable JJ cord-309048-emmtplv3 346 27 for for IN cord-309048-emmtplv3 346 28 prolonged prolonged JJ cord-309048-emmtplv3 346 29 storage storage NN cord-309048-emmtplv3 346 30 and and CC cord-309048-emmtplv3 346 31 shipment shipment NN cord-309048-emmtplv3 346 32 at at IN cord-309048-emmtplv3 346 33 ambient ambient JJ cord-309048-emmtplv3 346 34 temperatures temperature NNS cord-309048-emmtplv3 347 1 Engineered engineer VBN cord-309048-emmtplv3 347 2 tobacco tobacco NN cord-309048-emmtplv3 347 3 mosaic mosaic NN cord-309048-emmtplv3 347 4 virus virus NN cord-309048-emmtplv3 347 5 mutants mutant NNS cord-309048-emmtplv3 347 6 with with IN cord-309048-emmtplv3 347 7 distinct distinct JJ cord-309048-emmtplv3 347 8 physical physical JJ cord-309048-emmtplv3 347 9 characteristics characteristic NNS cord-309048-emmtplv3 347 10 in in IN cord-309048-emmtplv3 347 11 planta planta NN cord-309048-emmtplv3 347 12 and and CC cord-309048-emmtplv3 347 13 enhanced enhanced JJ cord-309048-emmtplv3 347 14 metallization metallization NN cord-309048-emmtplv3 347 15 properties property NNS cord-309048-emmtplv3 348 1 In in IN cord-309048-emmtplv3 348 2 vivo vivo NNP cord-309048-emmtplv3 348 3 self self NN cord-309048-emmtplv3 348 4 - - HYPH cord-309048-emmtplv3 348 5 assembly assembly NN cord-309048-emmtplv3 348 6 of of IN cord-309048-emmtplv3 348 7 TMV TMV NNP cord-309048-emmtplv3 348 8 - - HYPH cord-309048-emmtplv3 348 9 like like JJ cord-309048-emmtplv3 348 10 particles particle NNS cord-309048-emmtplv3 348 11 in in IN cord-309048-emmtplv3 348 12 yeast yeast NN cord-309048-emmtplv3 348 13 and and CC cord-309048-emmtplv3 348 14 bacteria bacteria NNS cord-309048-emmtplv3 348 15 for for IN cord-309048-emmtplv3 348 16 nanotechnological nanotechnological JJ cord-309048-emmtplv3 348 17 applications application NNS cord-309048-emmtplv3 348 18 Immunogenic immunogenic JJ cord-309048-emmtplv3 348 19 compositions composition NNS cord-309048-emmtplv3 348 20 assembled assemble VBN cord-309048-emmtplv3 348 21 from from IN cord-309048-emmtplv3 348 22 tobacco tobacco NN cord-309048-emmtplv3 348 23 mosaic mosaic JJ cord-309048-emmtplv3 348 24 virus virus NN cord-309048-emmtplv3 348 25 - - HYPH cord-309048-emmtplv3 348 26 generated generate VBN cord-309048-emmtplv3 348 27 spherical spherical JJ cord-309048-emmtplv3 348 28 particle particle NN cord-309048-emmtplv3 348 29 platforms platform NNS cord-309048-emmtplv3 348 30 and and CC cord-309048-emmtplv3 348 31 foreign foreign JJ cord-309048-emmtplv3 348 32 antigens antigen NNS cord-309048-emmtplv3 349 1 The the DT cord-309048-emmtplv3 349 2 synergistic synergistic JJ cord-309048-emmtplv3 349 3 effects effect NNS cord-309048-emmtplv3 349 4 of of IN cord-309048-emmtplv3 349 5 multivalent multivalent JJ cord-309048-emmtplv3 349 6 ligand ligand NN cord-309048-emmtplv3 349 7 display display NN cord-309048-emmtplv3 349 8 and and CC cord-309048-emmtplv3 349 9 nanotopography nanotopography NN cord-309048-emmtplv3 349 10 on on IN cord-309048-emmtplv3 349 11 osteogenic osteogenic JJ cord-309048-emmtplv3 349 12 differentiation differentiation NN cord-309048-emmtplv3 349 13 of of IN cord-309048-emmtplv3 349 14 rat rat NN cord-309048-emmtplv3 349 15 bone bone NN cord-309048-emmtplv3 349 16 marrow marrow NN cord-309048-emmtplv3 349 17 stem stem NN cord-309048-emmtplv3 349 18 cells cell NNS cord-309048-emmtplv3 350 1 Electrochemical electrochemical JJ cord-309048-emmtplv3 350 2 modification modification NN cord-309048-emmtplv3 350 3 of of IN cord-309048-emmtplv3 350 4 individual individual JJ cord-309048-emmtplv3 350 5 nano nano NN cord-309048-emmtplv3 350 6 - - HYPH cord-309048-emmtplv3 350 7 objects object NNS cord-309048-emmtplv3 350 8 Biotemplate Biotemplate NNP cord-309048-emmtplv3 350 9 synthesis synthesis NN cord-309048-emmtplv3 350 10 of of IN cord-309048-emmtplv3 350 11 3-nm 3-nm CD cord-309048-emmtplv3 350 12 nickel nickel NN cord-309048-emmtplv3 350 13 and and CC cord-309048-emmtplv3 350 14 cobalt cobalt NN cord-309048-emmtplv3 350 15 nanowires nanowire NNS cord-309048-emmtplv3 350 16 Binding bind VBG cord-309048-emmtplv3 350 17 the the DT cord-309048-emmtplv3 350 18 tobacco tobacco NN cord-309048-emmtplv3 350 19 mosaic mosaic NN cord-309048-emmtplv3 350 20 virus virus NN cord-309048-emmtplv3 350 21 to to IN cord-309048-emmtplv3 350 22 inorganic inorganic JJ cord-309048-emmtplv3 350 23 surfaces surface NNS cord-309048-emmtplv3 351 1 Spatially spatially RB cord-309048-emmtplv3 351 2 selective selective JJ cord-309048-emmtplv3 351 3 nucleation nucleation NN cord-309048-emmtplv3 351 4 of of IN cord-309048-emmtplv3 351 5 metal metal NN cord-309048-emmtplv3 351 6 clusters cluster NNS cord-309048-emmtplv3 351 7 on on IN cord-309048-emmtplv3 351 8 the the DT cord-309048-emmtplv3 351 9 tobacco tobacco NN cord-309048-emmtplv3 351 10 mosaic mosaic NN cord-309048-emmtplv3 351 11 virus virus NN cord-309048-emmtplv3 351 12 Modified modify VBD cord-309048-emmtplv3 351 13 TMV TMV NNP cord-309048-emmtplv3 351 14 particles particle NNS cord-309048-emmtplv3 351 15 as as IN cord-309048-emmtplv3 351 16 beneficial beneficial JJ cord-309048-emmtplv3 351 17 scaffolds scaffold NNS cord-309048-emmtplv3 351 18 to to TO cord-309048-emmtplv3 351 19 present present VB cord-309048-emmtplv3 351 20 sensor sensor NN cord-309048-emmtplv3 351 21 enzymes enzyme NNS cord-309048-emmtplv3 351 22 Novel novel JJ cord-309048-emmtplv3 351 23 roles role NNS cord-309048-emmtplv3 351 24 for for IN cord-309048-emmtplv3 351 25 well well RB cord-309048-emmtplv3 351 26 - - HYPH cord-309048-emmtplv3 351 27 known know VBN cord-309048-emmtplv3 351 28 players player NNS cord-309048-emmtplv3 351 29 : : : cord-309048-emmtplv3 351 30 from from IN cord-309048-emmtplv3 351 31 tobacco tobacco NN cord-309048-emmtplv3 351 32 mosaic mosaic JJ cord-309048-emmtplv3 351 33 virus virus NN cord-309048-emmtplv3 351 34 pests pest NNS cord-309048-emmtplv3 351 35 to to IN cord-309048-emmtplv3 351 36 enzymatically enzymatically RB cord-309048-emmtplv3 351 37 active active JJ cord-309048-emmtplv3 351 38 assemblies assembly NNS cord-309048-emmtplv3 351 39 Penicillin Penicillin NNP cord-309048-emmtplv3 351 40 detection detection NN cord-309048-emmtplv3 351 41 by by IN cord-309048-emmtplv3 351 42 tobacco tobacco NN cord-309048-emmtplv3 351 43 mosaic mosaic NN cord-309048-emmtplv3 351 44 virus virus NN cord-309048-emmtplv3 351 45 - - HYPH cord-309048-emmtplv3 351 46 assisted assist VBN cord-309048-emmtplv3 351 47 colorimetric colorimetric JJ cord-309048-emmtplv3 351 48 biosensors biosensor NNS cord-309048-emmtplv3 352 1 Protective protective JJ cord-309048-emmtplv3 352 2 immunity immunity NN cord-309048-emmtplv3 352 3 against against IN cord-309048-emmtplv3 352 4 murine murine JJ cord-309048-emmtplv3 352 5 hepatitis hepatitis NN cord-309048-emmtplv3 352 6 virus virus NN cord-309048-emmtplv3 352 7 ( ( -LRB- cord-309048-emmtplv3 352 8 MHV mhv NN cord-309048-emmtplv3 352 9 ) ) -RRB- cord-309048-emmtplv3 352 10 induced induce VBN cord-309048-emmtplv3 352 11 by by IN cord-309048-emmtplv3 352 12 intranasal intranasal NN cord-309048-emmtplv3 352 13 or or CC cord-309048-emmtplv3 352 14 subcutaneous subcutaneous JJ cord-309048-emmtplv3 352 15 administration administration NN cord-309048-emmtplv3 352 16 of of IN cord-309048-emmtplv3 352 17 hybrids hybrid NNS cord-309048-emmtplv3 352 18 of of IN cord-309048-emmtplv3 352 19 tobacco tobacco NN cord-309048-emmtplv3 352 20 mosaic mosaic JJ cord-309048-emmtplv3 352 21 virus virus NN cord-309048-emmtplv3 352 22 that that WDT cord-309048-emmtplv3 352 23 carries carry VBZ cord-309048-emmtplv3 352 24 an an DT cord-309048-emmtplv3 352 25 MHV MHV NNP cord-309048-emmtplv3 352 26 epitope epitope NN cord-309048-emmtplv3 352 27 Rapid Rapid NNP cord-309048-emmtplv3 352 28 deposition deposition NN cord-309048-emmtplv3 352 29 and and CC cord-309048-emmtplv3 352 30 long long JJ cord-309048-emmtplv3 352 31 - - HYPH cord-309048-emmtplv3 352 32 range range NN cord-309048-emmtplv3 352 33 alignment alignment NN cord-309048-emmtplv3 352 34 of of IN cord-309048-emmtplv3 352 35 nanocoatings nanocoating NNS cord-309048-emmtplv3 352 36 and and CC cord-309048-emmtplv3 352 37 arrays array NNS cord-309048-emmtplv3 352 38 of of IN cord-309048-emmtplv3 352 39 electrically electrically RB cord-309048-emmtplv3 352 40 conductive conductive JJ cord-309048-emmtplv3 352 41 wires wire NNS cord-309048-emmtplv3 352 42 from from IN cord-309048-emmtplv3 352 43 tobacco tobacco NN cord-309048-emmtplv3 352 44 mosaic mosaic NN cord-309048-emmtplv3 352 45 virus virus NN cord-309048-emmtplv3 352 46 Bioengineering Bioengineering NNP cord-309048-emmtplv3 352 47 of of IN cord-309048-emmtplv3 352 48 tobacco tobacco NN cord-309048-emmtplv3 352 49 mosaic mosaic NN cord-309048-emmtplv3 352 50 virus virus NN cord-309048-emmtplv3 352 51 to to TO cord-309048-emmtplv3 352 52 create create VB cord-309048-emmtplv3 352 53 a a DT cord-309048-emmtplv3 352 54 non non JJ cord-309048-emmtplv3 352 55 - - JJ cord-309048-emmtplv3 352 56 infectious infectious JJ cord-309048-emmtplv3 352 57 positive positive JJ cord-309048-emmtplv3 352 58 control control NN cord-309048-emmtplv3 352 59 for for IN cord-309048-emmtplv3 352 60 Ebola Ebola NNP cord-309048-emmtplv3 352 61 diagnostic diagnostic JJ cord-309048-emmtplv3 352 62 assays assay NNS cord-309048-emmtplv3 352 63 Virus virus NN cord-309048-emmtplv3 352 64 - - HYPH cord-309048-emmtplv3 352 65 based base VBN cord-309048-emmtplv3 352 66 nanoparticles nanoparticle NNS cord-309048-emmtplv3 352 67 as as IN cord-309048-emmtplv3 352 68 platform platform NN cord-309048-emmtplv3 352 69 technologies technology NNS cord-309048-emmtplv3 352 70 for for IN cord-309048-emmtplv3 352 71 modern modern JJ cord-309048-emmtplv3 352 72 vaccines vaccine NNS cord-309048-emmtplv3 352 73 Crystal Crystal NNP cord-309048-emmtplv3 352 74 structure structure NN cord-309048-emmtplv3 352 75 of of IN cord-309048-emmtplv3 352 76 a a DT cord-309048-emmtplv3 352 77 four four CD cord-309048-emmtplv3 352 78 - - HYPH cord-309048-emmtplv3 352 79 layer layer NN cord-309048-emmtplv3 352 80 aggregate aggregate NN cord-309048-emmtplv3 352 81 of of IN cord-309048-emmtplv3 352 82 engineered engineer VBN cord-309048-emmtplv3 352 83 TMV TMV NNP cord-309048-emmtplv3 352 84 CP CP NNP cord-309048-emmtplv3 352 85 implies imply VBZ cord-309048-emmtplv3 352 86 the the DT cord-309048-emmtplv3 352 87 importance importance NN cord-309048-emmtplv3 352 88 of of IN cord-309048-emmtplv3 352 89 terminal terminal JJ cord-309048-emmtplv3 352 90 residues residue NNS cord-309048-emmtplv3 352 91 for for IN cord-309048-emmtplv3 352 92 oligomer oligomer NNP cord-309048-emmtplv3 352 93 assembly assembly NNP cord-309048-emmtplv3 352 94 Self Self NNP cord-309048-emmtplv3 352 95 - - HYPH cord-309048-emmtplv3 352 96 assembly assembly NNP cord-309048-emmtplv3 352 97 of of IN cord-309048-emmtplv3 352 98 rod rod NN cord-309048-emmtplv3 352 99 - - HYPH cord-309048-emmtplv3 352 100 like like JJ cord-309048-emmtplv3 352 101 bionanoparticles bionanoparticle NNS cord-309048-emmtplv3 352 102 in in IN cord-309048-emmtplv3 352 103 capillary capillary JJ cord-309048-emmtplv3 352 104 tubes tube NNS cord-309048-emmtplv3 352 105 High high JJ cord-309048-emmtplv3 352 106 - - HYPH cord-309048-emmtplv3 352 107 efficiency efficiency NN cord-309048-emmtplv3 352 108 protein protein NN cord-309048-emmtplv3 352 109 expression expression NN cord-309048-emmtplv3 352 110 in in IN cord-309048-emmtplv3 352 111 plants plant NNS cord-309048-emmtplv3 352 112 from from IN cord-309048-emmtplv3 352 113 agroinfectioncompatible agroinfectioncompatible JJ cord-309048-emmtplv3 352 114 tobacco tobacco NN cord-309048-emmtplv3 352 115 mosaic mosaic NNP cord-309048-emmtplv3 352 116 virus virus NN cord-309048-emmtplv3 352 117 expression expression NN cord-309048-emmtplv3 352 118 vectors vector VBZ cord-309048-emmtplv3 352 119 Size size NN cord-309048-emmtplv3 352 120 dependent dependent JJ cord-309048-emmtplv3 352 121 cellular cellular JJ cord-309048-emmtplv3 352 122 uptake uptake NN cord-309048-emmtplv3 352 123 of of IN cord-309048-emmtplv3 352 124 rod rod NN cord-309048-emmtplv3 352 125 - - HYPH cord-309048-emmtplv3 352 126 like like JJ cord-309048-emmtplv3 352 127 bionanoparticles bionanoparticle NNS cord-309048-emmtplv3 352 128 with with IN cord-309048-emmtplv3 352 129 different different JJ cord-309048-emmtplv3 352 130 aspect aspect NN cord-309048-emmtplv3 352 131 ratios ratio NNS cord-309048-emmtplv3 353 1 So so CC cord-309048-emmtplv3 353 2 what what WP cord-309048-emmtplv3 353 3 have have VBP cord-309048-emmtplv3 353 4 plant plant NN cord-309048-emmtplv3 353 5 viruses virus NNS cord-309048-emmtplv3 353 6 ever ever RB cord-309048-emmtplv3 353 7 done do VBN cord-309048-emmtplv3 353 8 for for IN cord-309048-emmtplv3 353 9 virology virology NN cord-309048-emmtplv3 353 10 and and CC cord-309048-emmtplv3 353 11 molecular molecular JJ cord-309048-emmtplv3 353 12 biology biology NN cord-309048-emmtplv3 353 13 ? ? . cord-309048-emmtplv3 354 1 Structure structure NN cord-309048-emmtplv3 354 2 and and CC cord-309048-emmtplv3 354 3 in in IN cord-309048-emmtplv3 354 4 vitro vitro FW cord-309048-emmtplv3 354 5 assembly assembly NNP cord-309048-emmtplv3 354 6 of of IN cord-309048-emmtplv3 354 7 tobacco tobacco NNP cord-309048-emmtplv3 354 8 mosaic mosaic NNP cord-309048-emmtplv3 354 9 virus virus NN cord-309048-emmtplv3 355 1 A a DT cord-309048-emmtplv3 355 2 genetically genetically RB cord-309048-emmtplv3 355 3 modified modify VBN cord-309048-emmtplv3 355 4 tobacco tobacco NN cord-309048-emmtplv3 355 5 mosaic mosaic NN cord-309048-emmtplv3 355 6 virus virus NN cord-309048-emmtplv3 355 7 that that WDT cord-309048-emmtplv3 355 8 can can MD cord-309048-emmtplv3 355 9 produce produce VB cord-309048-emmtplv3 355 10 gold gold NN cord-309048-emmtplv3 355 11 nanoparticles nanoparticle NNS cord-309048-emmtplv3 355 12 from from IN cord-309048-emmtplv3 355 13 a a DT cord-309048-emmtplv3 355 14 metal metal NN cord-309048-emmtplv3 355 15 salt salt NN cord-309048-emmtplv3 355 16 precursor precursor NN cord-309048-emmtplv3 356 1 Simple simple JJ cord-309048-emmtplv3 356 2 , , , cord-309048-emmtplv3 356 3 readily readily RB cord-309048-emmtplv3 356 4 controllable controllable JJ cord-309048-emmtplv3 356 5 palladium palladium NN cord-309048-emmtplv3 356 6 nanoparticle nanoparticle NN cord-309048-emmtplv3 356 7 formation formation NN cord-309048-emmtplv3 356 8 on on IN cord-309048-emmtplv3 356 9 surface surface NN cord-309048-emmtplv3 356 10 - - HYPH cord-309048-emmtplv3 356 11 assembled assemble VBN cord-309048-emmtplv3 356 12 viral viral JJ cord-309048-emmtplv3 356 13 nanotemplates nanotemplate NNS cord-309048-emmtplv3 357 1 In in IN cord-309048-emmtplv3 357 2 planta planta NN cord-309048-emmtplv3 357 3 engineering engineering NN cord-309048-emmtplv3 357 4 of of IN cord-309048-emmtplv3 357 5 viral viral JJ cord-309048-emmtplv3 357 6 RNA RNA NNP cord-309048-emmtplv3 357 7 replicons replicon NNS cord-309048-emmtplv3 357 8 : : : cord-309048-emmtplv3 357 9 efficient efficient JJ cord-309048-emmtplv3 357 10 assembly assembly NN cord-309048-emmtplv3 357 11 by by IN cord-309048-emmtplv3 357 12 recombination recombination NN cord-309048-emmtplv3 357 13 of of IN cord-309048-emmtplv3 357 14 DNA dna NN cord-309048-emmtplv3 357 15 modules module NNS cord-309048-emmtplv3 357 16 delivered deliver VBN cord-309048-emmtplv3 357 17 by by IN cord-309048-emmtplv3 357 18 agrobacterium agrobacterium NN cord-309048-emmtplv3 357 19 Directed direct VBN cord-309048-emmtplv3 357 20 growth growth NN cord-309048-emmtplv3 357 21 of of IN cord-309048-emmtplv3 357 22 virus virus NN cord-309048-emmtplv3 357 23 nanofilaments nanofilament VBZ cord-309048-emmtplv3 357 24 on on IN cord-309048-emmtplv3 357 25 a a DT cord-309048-emmtplv3 357 26 superhydrophobic superhydrophobic JJ cord-309048-emmtplv3 357 27 surface surface NN cord-309048-emmtplv3 357 28 Gene Gene NNP cord-309048-emmtplv3 357 29 silencing silencing NN cord-309048-emmtplv3 357 30 and and CC cord-309048-emmtplv3 357 31 gene gene NN cord-309048-emmtplv3 357 32 expression expression NN cord-309048-emmtplv3 357 33 in in IN cord-309048-emmtplv3 357 34 phytopathogenic phytopathogenic JJ cord-309048-emmtplv3 357 35 fungi fungus NNS cord-309048-emmtplv3 357 36 using use VBG cord-309048-emmtplv3 357 37 a a DT cord-309048-emmtplv3 357 38 plant plant NN cord-309048-emmtplv3 357 39 virus virus NN cord-309048-emmtplv3 357 40 vector vector NN cord-309048-emmtplv3 357 41 Genetically genetically RB cord-309048-emmtplv3 357 42 engineered engineer VBN cord-309048-emmtplv3 357 43 tobacco tobacco NN cord-309048-emmtplv3 357 44 mosaic mosaic NN cord-309048-emmtplv3 357 45 virus virus NN cord-309048-emmtplv3 357 46 as as IN cord-309048-emmtplv3 357 47 nanoparticle nanoparticle NN cord-309048-emmtplv3 357 48 vaccines vaccine NNS cord-309048-emmtplv3 357 49 In in IN cord-309048-emmtplv3 357 50 vitro vitro FW cord-309048-emmtplv3 357 51 transcription transcription NN cord-309048-emmtplv3 357 52 of of IN cord-309048-emmtplv3 357 53 infectious infectious JJ cord-309048-emmtplv3 357 54 RNAs rna NNS cord-309048-emmtplv3 357 55 from from IN cord-309048-emmtplv3 357 56 full full JJ cord-309048-emmtplv3 357 57 - - HYPH cord-309048-emmtplv3 357 58 length length NN cord-309048-emmtplv3 357 59 cDNAs cdna NNS cord-309048-emmtplv3 357 60 of of IN cord-309048-emmtplv3 357 61 tobacco tobacco NN cord-309048-emmtplv3 357 62 mosaic mosaic NN cord-309048-emmtplv3 357 63 virus virus NN cord-309048-emmtplv3 358 1 In in IN cord-309048-emmtplv3 358 2 vitro vitro FW cord-309048-emmtplv3 358 3 assembly assembly NN cord-309048-emmtplv3 358 4 of of IN cord-309048-emmtplv3 358 5 tobacco tobacco NNP cord-309048-emmtplv3 358 6 mosaic mosaic NNP cord-309048-emmtplv3 358 7 virus virus NN cord-309048-emmtplv3 358 8 coat coat NN cord-309048-emmtplv3 358 9 protein protein NN cord-309048-emmtplv3 358 10 variants variant NNS cord-309048-emmtplv3 358 11 derived derive VBN cord-309048-emmtplv3 358 12 from from IN cord-309048-emmtplv3 358 13 fission fission NN cord-309048-emmtplv3 358 14 yeast yeast NN cord-309048-emmtplv3 358 15 expression expression NN cord-309048-emmtplv3 358 16 clones clone NNS cord-309048-emmtplv3 358 17 or or CC cord-309048-emmtplv3 358 18 plants plant NNS cord-309048-emmtplv3 358 19 Inducible inducible JJ cord-309048-emmtplv3 358 20 site site NN cord-309048-emmtplv3 358 21 - - HYPH cord-309048-emmtplv3 358 22 selective selective JJ cord-309048-emmtplv3 358 23 bottom bottom NN cord-309048-emmtplv3 358 24 - - HYPH cord-309048-emmtplv3 358 25 up up NN cord-309048-emmtplv3 358 26 assembly assembly NN cord-309048-emmtplv3 358 27 of of IN cord-309048-emmtplv3 358 28 virus virus NN cord-309048-emmtplv3 358 29 - - HYPH cord-309048-emmtplv3 358 30 derived derive VBN cord-309048-emmtplv3 358 31 nanotube nanotube NN cord-309048-emmtplv3 358 32 arrays array NNS cord-309048-emmtplv3 358 33 on on IN cord-309048-emmtplv3 358 34 RNA RNA NNP cord-309048-emmtplv3 358 35 - - HYPH cord-309048-emmtplv3 358 36 equipped equip VBN cord-309048-emmtplv3 358 37 wafers wafer NNS cord-309048-emmtplv3 358 38 Visualization visualization NN cord-309048-emmtplv3 358 39 of of IN cord-309048-emmtplv3 358 40 protein protein NN cord-309048-emmtplv3 358 41 - - HYPH cord-309048-emmtplv3 358 42 nucleic nucleic JJ cord-309048-emmtplv3 358 43 acid acid NN cord-309048-emmtplv3 358 44 interactions interaction NNS cord-309048-emmtplv3 358 45 in in IN cord-309048-emmtplv3 358 46 a a DT cord-309048-emmtplv3 358 47 virus virus NN cord-309048-emmtplv3 358 48 . . . cord-309048-emmtplv3 359 1 Refined refined JJ cord-309048-emmtplv3 359 2 structure structure NN cord-309048-emmtplv3 359 3 of of IN cord-309048-emmtplv3 359 4 intact intact JJ cord-309048-emmtplv3 359 5 tobacco tobacco NN cord-309048-emmtplv3 359 6 mosaic mosaic JJ cord-309048-emmtplv3 359 7 virus virus NN cord-309048-emmtplv3 359 8 at at IN cord-309048-emmtplv3 359 9 2.9 2.9 CD cord-309048-emmtplv3 359 10 Å å NN cord-309048-emmtplv3 359 11 resolution resolution NN cord-309048-emmtplv3 359 12 by by IN cord-309048-emmtplv3 359 13 X x NN cord-309048-emmtplv3 359 14 - - NN cord-309048-emmtplv3 359 15 ray ray JJ cord-309048-emmtplv3 359 16 fiber fiber NN cord-309048-emmtplv3 359 17 diffraction diffraction NN cord-309048-emmtplv3 360 1 Ordered order VBN cord-309048-emmtplv3 360 2 association association NNP cord-309048-emmtplv3 360 3 of of IN cord-309048-emmtplv3 360 4 tobacco tobacco NNP cord-309048-emmtplv3 360 5 mosaic mosaic NNP cord-309048-emmtplv3 360 6 virus virus NN cord-309048-emmtplv3 360 7 in in IN cord-309048-emmtplv3 360 8 the the DT cord-309048-emmtplv3 360 9 presence presence NN cord-309048-emmtplv3 360 10 of of IN cord-309048-emmtplv3 360 11 divalent divalent JJ cord-309048-emmtplv3 360 12 metal metal NN cord-309048-emmtplv3 360 13 ions ion NNS cord-309048-emmtplv3 360 14 Selfassembly selfassembly RB cord-309048-emmtplv3 360 15 of of IN cord-309048-emmtplv3 360 16 anisotropic anisotropic JJ cord-309048-emmtplv3 360 17 tobacco tobacco NN cord-309048-emmtplv3 360 18 mosaic mosaic NN cord-309048-emmtplv3 360 19 virus virus NN cord-309048-emmtplv3 360 20 nanoparticles nanoparticle VBZ cord-309048-emmtplv3 360 21 on on IN cord-309048-emmtplv3 360 22 gold gold NN cord-309048-emmtplv3 360 23 substrate substrate NN cord-309048-emmtplv3 361 1 The the DT cord-309048-emmtplv3 361 2 characterization characterization NN cord-309048-emmtplv3 361 3 of of IN cord-309048-emmtplv3 361 4 intermediates intermediate NNS cord-309048-emmtplv3 361 5 formed form VBN cord-309048-emmtplv3 361 6 during during IN cord-309048-emmtplv3 361 7 the the DT cord-309048-emmtplv3 361 8 disassembly disassembly NN cord-309048-emmtplv3 361 9 of of IN cord-309048-emmtplv3 361 10 tobacco tobacco NN cord-309048-emmtplv3 361 11 mosaic mosaic JJ cord-309048-emmtplv3 361 12 virus virus NN cord-309048-emmtplv3 361 13 at at IN cord-309048-emmtplv3 361 14 alkaline alkaline JJ cord-309048-emmtplv3 361 15 pH pH NNP cord-309048-emmtplv3 361 16 Immunogenicity Immunogenicity NNP cord-309048-emmtplv3 361 17 and and CC cord-309048-emmtplv3 361 18 protective protective JJ cord-309048-emmtplv3 361 19 efficacy efficacy NN cord-309048-emmtplv3 361 20 of of IN cord-309048-emmtplv3 361 21 candidate candidate NN cord-309048-emmtplv3 361 22 universal universal JJ cord-309048-emmtplv3 361 23 influenza influenza NN cord-309048-emmtplv3 361 24 A a DT cord-309048-emmtplv3 361 25 nanovaccines nanovaccine NNS cord-309048-emmtplv3 361 26 produced produce VBN cord-309048-emmtplv3 361 27 in in IN cord-309048-emmtplv3 361 28 plants plant NNS cord-309048-emmtplv3 361 29 by by IN cord-309048-emmtplv3 361 30 tobacco tobacco NN cord-309048-emmtplv3 361 31 mosaic mosaic JJ cord-309048-emmtplv3 361 32 virus virus NN cord-309048-emmtplv3 361 33 - - HYPH cord-309048-emmtplv3 361 34 based base VBN cord-309048-emmtplv3 361 35 vectors vector NNS cord-309048-emmtplv3 361 36 When when WRB cord-309048-emmtplv3 361 37 plant plant NN cord-309048-emmtplv3 361 38 virology virology NN cord-309048-emmtplv3 361 39 met meet VBD cord-309048-emmtplv3 361 40 agrobacterium agrobacterium NNP cord-309048-emmtplv3 361 41 : : : cord-309048-emmtplv3 361 42 the the DT cord-309048-emmtplv3 361 43 rise rise NN cord-309048-emmtplv3 361 44 of of IN cord-309048-emmtplv3 361 45 the the DT cord-309048-emmtplv3 361 46 deconstructed deconstruct VBN cord-309048-emmtplv3 361 47 clones clone NNS cord-309048-emmtplv3 361 48 Field field NN cord-309048-emmtplv3 361 49 - - HYPH cord-309048-emmtplv3 361 50 effect effect NN cord-309048-emmtplv3 361 51 biosensor biosensor NN cord-309048-emmtplv3 361 52 using use VBG cord-309048-emmtplv3 361 53 virus virus NN cord-309048-emmtplv3 361 54 particles particle NNS cord-309048-emmtplv3 361 55 as as IN cord-309048-emmtplv3 361 56 scaffolds scaffold NNS cord-309048-emmtplv3 361 57 for for IN cord-309048-emmtplv3 361 58 enzyme enzyme NN cord-309048-emmtplv3 361 59 immobilization immobilization NN cord-309048-emmtplv3 361 60 Delay delay NN cord-309048-emmtplv3 361 61 of of IN cord-309048-emmtplv3 361 62 disease disease NN cord-309048-emmtplv3 361 63 development development NN cord-309048-emmtplv3 361 64 in in IN cord-309048-emmtplv3 361 65 transgenic transgenic JJ cord-309048-emmtplv3 361 66 plants plant NNS cord-309048-emmtplv3 361 67 that that WDT cord-309048-emmtplv3 361 68 express express VBP cord-309048-emmtplv3 361 69 the the DT cord-309048-emmtplv3 361 70 tobacco tobacco NN cord-309048-emmtplv3 361 71 mosaic mosaic NNP cord-309048-emmtplv3 361 72 virus virus NN cord-309048-emmtplv3 361 73 coat coat NN cord-309048-emmtplv3 361 74 - - HYPH cord-309048-emmtplv3 361 75 protein protein NN cord-309048-emmtplv3 361 76 gene gene NN cord-309048-emmtplv3 361 77 Biologically biologically RB cord-309048-emmtplv3 361 78 inspired inspire VBD cord-309048-emmtplv3 361 79 strategy strategy NN cord-309048-emmtplv3 361 80 for for IN cord-309048-emmtplv3 361 81 programmed program VBN cord-309048-emmtplv3 361 82 assembly assembly NN cord-309048-emmtplv3 361 83 of of IN cord-309048-emmtplv3 361 84 viral viral JJ cord-309048-emmtplv3 361 85 building building NN cord-309048-emmtplv3 361 86 blocks block NNS cord-309048-emmtplv3 361 87 with with IN cord-309048-emmtplv3 361 88 controlled control VBN cord-309048-emmtplv3 361 89 dimensions dimension NNS cord-309048-emmtplv3 361 90 Self self NN cord-309048-emmtplv3 361 91 - - HYPH cord-309048-emmtplv3 361 92 assembly assembly NN cord-309048-emmtplv3 361 93 of of IN cord-309048-emmtplv3 361 94 virus virus NN cord-309048-emmtplv3 361 95 - - HYPH cord-309048-emmtplv3 361 96 structured structure VBN cord-309048-emmtplv3 361 97 high high JJ cord-309048-emmtplv3 361 98 surface surface NN cord-309048-emmtplv3 361 99 area area NN cord-309048-emmtplv3 361 100 nanomaterials nanomaterial NNS cord-309048-emmtplv3 361 101 and and CC cord-309048-emmtplv3 361 102 their -PRON- PRP$ cord-309048-emmtplv3 361 103 application application NN cord-309048-emmtplv3 361 104 as as IN cord-309048-emmtplv3 361 105 battery battery NN cord-309048-emmtplv3 361 106 electrodes electrode NNS cord-309048-emmtplv3 362 1 In in IN cord-309048-emmtplv3 362 2 planta planta NN cord-309048-emmtplv3 362 3 synthesis synthesis NN cord-309048-emmtplv3 362 4 of of IN cord-309048-emmtplv3 362 5 designer designer NN cord-309048-emmtplv3 362 6 - - HYPH cord-309048-emmtplv3 362 7 length length NN cord-309048-emmtplv3 362 8 tobacco tobacco NN cord-309048-emmtplv3 362 9 mosaic mosaic NN cord-309048-emmtplv3 362 10 virus virus NN cord-309048-emmtplv3 362 11 - - HYPH cord-309048-emmtplv3 362 12 based base VBN cord-309048-emmtplv3 362 13 nano nano NN cord-309048-emmtplv3 362 14 - - HYPH cord-309048-emmtplv3 362 15 rods rod NNS cord-309048-emmtplv3 362 16 that that WDT cord-309048-emmtplv3 362 17 can can MD cord-309048-emmtplv3 362 18 be be VB cord-309048-emmtplv3 362 19 used use VBN cord-309048-emmtplv3 362 20 to to TO cord-309048-emmtplv3 362 21 fabricate fabricate VB cord-309048-emmtplv3 362 22 nano nano NN cord-309048-emmtplv3 362 23 - - HYPH cord-309048-emmtplv3 362 24 wires wire NNS cord-309048-emmtplv3 362 25 Virus virus NN cord-309048-emmtplv3 362 26 - - HYPH cord-309048-emmtplv3 362 27 directed direct VBN cord-309048-emmtplv3 362 28 formation formation NN cord-309048-emmtplv3 362 29 of of IN cord-309048-emmtplv3 362 30 electrocatalytically electrocatalytically RB cord-309048-emmtplv3 362 31 active active JJ cord-309048-emmtplv3 362 32 nanoparticlebased nanoparticlebase VBN cord-309048-emmtplv3 362 33 Co co NN cord-309048-emmtplv3 363 1 3 3 CD cord-309048-emmtplv3 363 2 O o NN cord-309048-emmtplv3 363 3 4 4 CD cord-309048-emmtplv3 363 4 tubes tube NNS cord-309048-emmtplv3 363 5 Dual dual JJ cord-309048-emmtplv3 363 6 - - HYPH cord-309048-emmtplv3 363 7 surface surface NN cord-309048-emmtplv3 363 8 modification modification NN cord-309048-emmtplv3 363 9 of of IN cord-309048-emmtplv3 363 10 the the DT cord-309048-emmtplv3 363 11 tobacco tobacco NN cord-309048-emmtplv3 363 12 mosaic mosaic NN cord-309048-emmtplv3 363 13 virus virus NN cord-309048-emmtplv3 363 14 Inorganic Inorganic NNP cord-309048-emmtplv3 363 15 - - HYPH cord-309048-emmtplv3 363 16 organic organic JJ cord-309048-emmtplv3 363 17 nanotube nanotube NN cord-309048-emmtplv3 363 18 composites composite NNS cord-309048-emmtplv3 363 19 from from IN cord-309048-emmtplv3 363 20 template template NN cord-309048-emmtplv3 363 21 mineralization mineralization NN cord-309048-emmtplv3 363 22 of of IN cord-309048-emmtplv3 363 23 tobacco tobacco NN cord-309048-emmtplv3 363 24 mosaic mosaic NN cord-309048-emmtplv3 363 25 virus virus NN cord-309048-emmtplv3 363 26 Preparation preparation NN cord-309048-emmtplv3 363 27 and and CC cord-309048-emmtplv3 363 28 properties property NNS cord-309048-emmtplv3 363 29 of of IN cord-309048-emmtplv3 363 30 recombinant recombinant JJ cord-309048-emmtplv3 363 31 DNA dna NN cord-309048-emmtplv3 363 32 derived derive VBN cord-309048-emmtplv3 363 33 tobacco tobacco NN cord-309048-emmtplv3 363 34 mosaic mosaic NNP cord-309048-emmtplv3 363 35 virus virus NN cord-309048-emmtplv3 363 36 coat coat NN cord-309048-emmtplv3 363 37 protein protein NNP cord-309048-emmtplv3 364 1 The the DT cord-309048-emmtplv3 364 2 impact impact NN cord-309048-emmtplv3 364 3 of of IN cord-309048-emmtplv3 364 4 aspect aspect NN cord-309048-emmtplv3 364 5 ratio ratio NN cord-309048-emmtplv3 364 6 on on IN cord-309048-emmtplv3 364 7 biodistribution biodistribution NN cord-309048-emmtplv3 364 8 and and CC cord-309048-emmtplv3 364 9 tumor tumor NN cord-309048-emmtplv3 364 10 homing homing NN cord-309048-emmtplv3 364 11 of of IN cord-309048-emmtplv3 364 12 rigid rigid JJ cord-309048-emmtplv3 364 13 soft soft JJ cord-309048-emmtplv3 364 14 - - HYPH cord-309048-emmtplv3 364 15 matter matter NN cord-309048-emmtplv3 364 16 nanorods nanorods NNP cord-309048-emmtplv3 364 17 RGD RGD NNP cord-309048-emmtplv3 364 18 - - HYPH cord-309048-emmtplv3 364 19 conjugated conjugate VBN cord-309048-emmtplv3 364 20 rod rod NN cord-309048-emmtplv3 364 21 - - HYPH cord-309048-emmtplv3 364 22 like like JJ cord-309048-emmtplv3 364 23 viral viral JJ cord-309048-emmtplv3 364 24 nanoparticles nanoparticle NNS cord-309048-emmtplv3 364 25 on on IN cord-309048-emmtplv3 364 26 2D 2D NNP cord-309048-emmtplv3 364 27 scaffold scaffold NN cord-309048-emmtplv3 364 28 improve improve VB cord-309048-emmtplv3 364 29 bone bone NN cord-309048-emmtplv3 364 30 differentiation differentiation NN cord-309048-emmtplv3 364 31 of of IN cord-309048-emmtplv3 364 32 mesenchymal mesenchymal JJ cord-309048-emmtplv3 364 33 stem stem NN cord-309048-emmtplv3 364 34 cells cell NNS cord-309048-emmtplv3 364 35 Packaging Packaging NNP cord-309048-emmtplv3 364 36 of of IN cord-309048-emmtplv3 364 37 recombinant recombinant JJ cord-309048-emmtplv3 364 38 RNA RNA NNP cord-309048-emmtplv3 364 39 molecules molecule NNS cord-309048-emmtplv3 364 40 into into IN cord-309048-emmtplv3 364 41 pseudovirus pseudovirus NNP cord-309048-emmtplv3 364 42 particles particle NNS cord-309048-emmtplv3 364 43 directed direct VBN cord-309048-emmtplv3 364 44 by by IN cord-309048-emmtplv3 364 45 the the DT cord-309048-emmtplv3 364 46 originof originof NNP cord-309048-emmtplv3 364 47 - - HYPH cord-309048-emmtplv3 364 48 assembly assembly NN cord-309048-emmtplv3 364 49 sequence sequence NN cord-309048-emmtplv3 364 50 from from IN cord-309048-emmtplv3 364 51 tobacco tobacco NN cord-309048-emmtplv3 364 52 mosaic mosaic NNP cord-309048-emmtplv3 364 53 virus virus NN cord-309048-emmtplv3 365 1 RNA RNA NNP cord-309048-emmtplv3 365 2 Modified modify VBN cord-309048-emmtplv3 365 3 tobacco tobacco NN cord-309048-emmtplv3 365 4 mosaic mosaic NN cord-309048-emmtplv3 365 5 virus virus NN cord-309048-emmtplv3 365 6 particles particle NNS cord-309048-emmtplv3 365 7 as as IN cord-309048-emmtplv3 365 8 scaffolds scaffold NNS cord-309048-emmtplv3 365 9 for for IN cord-309048-emmtplv3 365 10 display display NN cord-309048-emmtplv3 365 11 of of IN cord-309048-emmtplv3 365 12 protein protein NN cord-309048-emmtplv3 365 13 antigens antigen NNS cord-309048-emmtplv3 365 14 for for IN cord-309048-emmtplv3 365 15 vaccine vaccine NN cord-309048-emmtplv3 365 16 applications application NNS cord-309048-emmtplv3 365 17 Assembly Assembly NNP cord-309048-emmtplv3 365 18 of of IN cord-309048-emmtplv3 365 19 trans trans NNP cord-309048-emmtplv3 365 20 - - JJ cord-309048-emmtplv3 365 21 encapsidated encapsidate VBN cord-309048-emmtplv3 365 22 recombinant recombinant JJ cord-309048-emmtplv3 365 23 viral viral JJ cord-309048-emmtplv3 365 24 vectors vector NNS cord-309048-emmtplv3 365 25 engineered engineer VBN cord-309048-emmtplv3 365 26 from from IN cord-309048-emmtplv3 365 27 tobacco tobacco NN cord-309048-emmtplv3 365 28 mosaic mosaic JJ cord-309048-emmtplv3 365 29 virus virus NN cord-309048-emmtplv3 365 30 and and CC cord-309048-emmtplv3 365 31 Semliki Semliki NNP cord-309048-emmtplv3 365 32 Forest Forest NNP cord-309048-emmtplv3 365 33 virus virus NN cord-309048-emmtplv3 365 34 and and CC cord-309048-emmtplv3 365 35 their -PRON- PRP$ cord-309048-emmtplv3 365 36 evaluation evaluation NN cord-309048-emmtplv3 365 37 as as IN cord-309048-emmtplv3 365 38 immunogens immunogens JJ cord-309048-emmtplv3 365 39 Display display NN cord-309048-emmtplv3 365 40 of of IN cord-309048-emmtplv3 365 41 peptides peptide NNS cord-309048-emmtplv3 365 42 on on IN cord-309048-emmtplv3 365 43 the the DT cord-309048-emmtplv3 365 44 surface surface NN cord-309048-emmtplv3 365 45 of of IN cord-309048-emmtplv3 365 46 tobacco tobacco NN cord-309048-emmtplv3 365 47 mosaic mosaic NN cord-309048-emmtplv3 365 48 virus virus NN cord-309048-emmtplv3 365 49 particles particle VBZ cord-309048-emmtplv3 365 50 Immunization Immunization NNP cord-309048-emmtplv3 365 51 with with IN cord-309048-emmtplv3 365 52 a a DT cord-309048-emmtplv3 365 53 chimeric chimeric JJ cord-309048-emmtplv3 365 54 tobacco tobacco NN cord-309048-emmtplv3 365 55 mosaic mosaic NN cord-309048-emmtplv3 365 56 virus virus NN cord-309048-emmtplv3 365 57 containing contain VBG cord-309048-emmtplv3 365 58 an an DT cord-309048-emmtplv3 365 59 epitope epitope NN cord-309048-emmtplv3 365 60 of of IN cord-309048-emmtplv3 365 61 outer outer JJ cord-309048-emmtplv3 365 62 membrane membrane NN cord-309048-emmtplv3 365 63 protein protein NN cord-309048-emmtplv3 365 64 F F NNP cord-309048-emmtplv3 365 65 of of IN cord-309048-emmtplv3 365 66 Pseudomonas Pseudomonas NNP cord-309048-emmtplv3 365 67 aeruginosa aeruginosa NN cord-309048-emmtplv3 365 68 provides provide VBZ cord-309048-emmtplv3 365 69 protection protection NN cord-309048-emmtplv3 365 70 against against IN cord-309048-emmtplv3 365 71 challenge challenge NN cord-309048-emmtplv3 365 72 with with IN cord-309048-emmtplv3 365 73 P. P. NNP cord-309048-emmtplv3 365 74 aeruginosa aeruginosa NNP cord-309048-emmtplv3 365 75 Synthetic synthetic JJ cord-309048-emmtplv3 365 76 plant plant NN cord-309048-emmtplv3 365 77 virology virology NN cord-309048-emmtplv3 365 78 for for IN cord-309048-emmtplv3 365 79 nanobiotechnology nanobiotechnology NN cord-309048-emmtplv3 365 80 and and CC cord-309048-emmtplv3 365 81 nanomedicine nanomedicine NN cord-309048-emmtplv3 365 82 Layer Layer NNP cord-309048-emmtplv3 365 83 - - HYPH cord-309048-emmtplv3 365 84 by by IN cord-309048-emmtplv3 365 85 - - HYPH cord-309048-emmtplv3 365 86 layer layer NN cord-309048-emmtplv3 365 87 assembly assembly NN cord-309048-emmtplv3 365 88 of of IN cord-309048-emmtplv3 365 89 viral viral JJ cord-309048-emmtplv3 365 90 nanoparticles nanoparticle NNS cord-309048-emmtplv3 365 91 and and CC cord-309048-emmtplv3 365 92 polyelectrolytes polyelectrolyte NNS cord-309048-emmtplv3 365 93 : : : cord-309048-emmtplv3 365 94 the the DT cord-309048-emmtplv3 365 95 film film NN cord-309048-emmtplv3 365 96 architecture architecture NN cord-309048-emmtplv3 365 97 is be VBZ cord-309048-emmtplv3 365 98 different different JJ cord-309048-emmtplv3 365 99 for for IN cord-309048-emmtplv3 365 100 spheres sphere NNS cord-309048-emmtplv3 365 101 versus versus IN cord-309048-emmtplv3 365 102 rods rod NNS cord-309048-emmtplv3 365 103 Chemical chemical JJ cord-309048-emmtplv3 365 104 modification modification NN cord-309048-emmtplv3 365 105 of of IN cord-309048-emmtplv3 365 106 viruses virus NNS cord-309048-emmtplv3 365 107 and and CC cord-309048-emmtplv3 365 108 virus virus NN cord-309048-emmtplv3 365 109 - - HYPH cord-309048-emmtplv3 365 110 like like JJ cord-309048-emmtplv3 365 111 particles particle NNS cord-309048-emmtplv3 365 112 Structure Structure NNP cord-309048-emmtplv3 365 113 of of IN cord-309048-emmtplv3 365 114 RNA RNA NNP cord-309048-emmtplv3 365 115 and and CC cord-309048-emmtplv3 365 116 RNA RNA NNP cord-309048-emmtplv3 365 117 binding binding NN cord-309048-emmtplv3 365 118 site site NN cord-309048-emmtplv3 365 119 in in IN cord-309048-emmtplv3 365 120 tobacco tobacco NN cord-309048-emmtplv3 365 121 mosaic mosaic NN cord-309048-emmtplv3 365 122 virus virus NN cord-309048-emmtplv3 365 123 from from IN cord-309048-emmtplv3 365 124 4-Å 4-å CD cord-309048-emmtplv3 365 125 map map NN cord-309048-emmtplv3 365 126 calculated calculate VBN cord-309048-emmtplv3 365 127 from from IN cord-309048-emmtplv3 365 128 X x NN cord-309048-emmtplv3 365 129 - - NN cord-309048-emmtplv3 365 130 ray ray JJ cord-309048-emmtplv3 365 131 fibre fibre NN cord-309048-emmtplv3 365 132 diagrams diagram NNS cord-309048-emmtplv3 365 133 Production production NN cord-309048-emmtplv3 365 134 of of IN cord-309048-emmtplv3 365 135 enkephalin enkephalin NN cord-309048-emmtplv3 365 136 in in IN cord-309048-emmtplv3 365 137 tobacco tobacco NN cord-309048-emmtplv3 365 138 protoplasts protoplast NNS cord-309048-emmtplv3 365 139 using use VBG cord-309048-emmtplv3 365 140 tobacco tobacco NN cord-309048-emmtplv3 365 141 mosaic mosaic NNP cord-309048-emmtplv3 365 142 virus virus NN cord-309048-emmtplv3 365 143 RNA RNA NNP cord-309048-emmtplv3 365 144 vector vector NN cord-309048-emmtplv3 365 145 Hierarchical Hierarchical NNP cord-309048-emmtplv3 365 146 assembly assembly NN cord-309048-emmtplv3 365 147 of of IN cord-309048-emmtplv3 365 148 viral viral JJ cord-309048-emmtplv3 365 149 nanotemplates nanotemplates NNPS cord-309048-emmtplv3 365 150 with with IN cord-309048-emmtplv3 365 151 encoded encode VBN cord-309048-emmtplv3 365 152 microparticles microparticle NNS cord-309048-emmtplv3 365 153 via via IN cord-309048-emmtplv3 365 154 nucleic nucleic JJ cord-309048-emmtplv3 365 155 acid acid NN cord-309048-emmtplv3 365 156 hybridization hybridization NN cord-309048-emmtplv3 365 157 Electrostatic electrostatic JJ cord-309048-emmtplv3 365 158 layer layer NN cord-309048-emmtplv3 365 159 - - HYPH cord-309048-emmtplv3 365 160 by by IN cord-309048-emmtplv3 365 161 - - HYPH cord-309048-emmtplv3 365 162 layer layer NN cord-309048-emmtplv3 365 163 construction construction NN cord-309048-emmtplv3 365 164 of of IN cord-309048-emmtplv3 365 165 fibrous fibrous JJ cord-309048-emmtplv3 365 166 TMV TMV NNP cord-309048-emmtplv3 365 167 biofilms biofilm NNS cord-309048-emmtplv3 365 168 Synthesis Synthesis NNP cord-309048-emmtplv3 365 169 of of IN cord-309048-emmtplv3 365 170 CoPt CoPt NNP cord-309048-emmtplv3 365 171 and and CC cord-309048-emmtplv3 365 172 FePt FePt NNP cord-309048-emmtplv3 365 173 3 3 CD cord-309048-emmtplv3 365 174 nanowires nanowire NNS cord-309048-emmtplv3 365 175 using use VBG cord-309048-emmtplv3 365 176 the the DT cord-309048-emmtplv3 365 177 central central JJ cord-309048-emmtplv3 365 178 channel channel NN cord-309048-emmtplv3 365 179 of of IN cord-309048-emmtplv3 365 180 tobacco tobacco NNP cord-309048-emmtplv3 365 181 mosaic mosaic NNP cord-309048-emmtplv3 365 182 virus virus NN cord-309048-emmtplv3 365 183 as as IN cord-309048-emmtplv3 365 184 a a DT cord-309048-emmtplv3 365 185 biotemplate biotemplate NNP cord-309048-emmtplv3 365 186 Assembly Assembly NNP cord-309048-emmtplv3 365 187 of of IN cord-309048-emmtplv3 365 188 hybrid hybrid JJ cord-309048-emmtplv3 365 189 RNAs rna NNS cord-309048-emmtplv3 365 190 with with IN cord-309048-emmtplv3 365 191 tobacco tobacco NN cord-309048-emmtplv3 365 192 mosaic mosaic NNP cord-309048-emmtplv3 365 193 virus virus NN cord-309048-emmtplv3 365 194 coat coat NN cord-309048-emmtplv3 365 195 protein protein NN cord-309048-emmtplv3 365 196 . . . cord-309048-emmtplv3 366 1 Evidence evidence NN cord-309048-emmtplv3 366 2 for for IN cord-309048-emmtplv3 366 3 incorporation incorporation NN cord-309048-emmtplv3 366 4 of of IN cord-309048-emmtplv3 366 5 disks disk NNS cord-309048-emmtplv3 366 6 in in IN cord-309048-emmtplv3 366 7 5 5 CD cord-309048-emmtplv3 366 8 0 0 CD cord-309048-emmtplv3 366 9 -elongation -elongation NN cord-309048-emmtplv3 366 10 along along IN cord-309048-emmtplv3 366 11 the the DT cord-309048-emmtplv3 366 12 major major JJ cord-309048-emmtplv3 366 13 RNA RNA NNP cord-309048-emmtplv3 366 14 tail tail NN cord-309048-emmtplv3 366 15 Malarial malarial JJ cord-309048-emmtplv3 366 16 epitopes epitope NNS cord-309048-emmtplv3 366 17 expressed express VBN cord-309048-emmtplv3 366 18 on on IN cord-309048-emmtplv3 366 19 the the DT cord-309048-emmtplv3 366 20 surface surface NN cord-309048-emmtplv3 366 21 of of IN cord-309048-emmtplv3 366 22 recombinant recombinant JJ cord-309048-emmtplv3 366 23 tobacco tobacco NN cord-309048-emmtplv3 366 24 mosaic mosaic NN cord-309048-emmtplv3 366 25 virus virus NN cord-309048-emmtplv3 366 26 Design Design NNP cord-309048-emmtplv3 366 27 of of IN cord-309048-emmtplv3 366 28 virus virus NN cord-309048-emmtplv3 366 29 - - HYPH cord-309048-emmtplv3 366 30 based base VBN cord-309048-emmtplv3 366 31 nanomaterials nanomaterial NNS cord-309048-emmtplv3 366 32 for for IN cord-309048-emmtplv3 366 33 medicine medicine NN cord-309048-emmtplv3 366 34 , , , cord-309048-emmtplv3 366 35 biotechnology biotechnology NN cord-309048-emmtplv3 366 36 , , , cord-309048-emmtplv3 366 37 and and CC cord-309048-emmtplv3 366 38 energy energy NN cord-309048-emmtplv3 366 39 Immunoabsorbent Immunoabsorbent NNP cord-309048-emmtplv3 366 40 nanoparticles nanoparticle NNS cord-309048-emmtplv3 366 41 based base VBN cord-309048-emmtplv3 366 42 on on IN cord-309048-emmtplv3 366 43 a a DT cord-309048-emmtplv3 366 44 tobamovirus tobamovirus JJ cord-309048-emmtplv3 366 45 displaying display VBG cord-309048-emmtplv3 366 46 protein protein NN cord-309048-emmtplv3 366 47 A a DT cord-309048-emmtplv3 366 48 Plant Plant NNP cord-309048-emmtplv3 366 49 viruses virus NNS cord-309048-emmtplv3 366 50 : : : cord-309048-emmtplv3 366 51 a a DT cord-309048-emmtplv3 366 52 tool tool NN cord-309048-emmtplv3 366 53 - - HYPH cord-309048-emmtplv3 366 54 box box NN cord-309048-emmtplv3 366 55 for for IN cord-309048-emmtplv3 366 56 genetic genetic JJ cord-309048-emmtplv3 366 57 engineering engineering NN cord-309048-emmtplv3 366 58 and and CC cord-309048-emmtplv3 366 59 crop crop NN cord-309048-emmtplv3 366 60 protection protection NN cord-309048-emmtplv3 366 61 Fabrication fabrication NN cord-309048-emmtplv3 366 62 and and CC cord-309048-emmtplv3 366 63 characterization characterization NN cord-309048-emmtplv3 366 64 of of IN cord-309048-emmtplv3 366 65 gold gold NN cord-309048-emmtplv3 366 66 nano nano NN cord-309048-emmtplv3 366 67 - - HYPH cord-309048-emmtplv3 366 68 wires wire NNS cord-309048-emmtplv3 366 69 template template NN cord-309048-emmtplv3 366 70 on on IN cord-309048-emmtplv3 366 71 virus virus NN cord-309048-emmtplv3 366 72 - - HYPH cord-309048-emmtplv3 366 73 like like JJ cord-309048-emmtplv3 366 74 arrays array NNS cord-309048-emmtplv3 366 75 of of IN cord-309048-emmtplv3 366 76 tobacco tobacco NN cord-309048-emmtplv3 366 77 mosaic mosaic NNP cord-309048-emmtplv3 366 78 virus virus NN cord-309048-emmtplv3 366 79 coat coat NN cord-309048-emmtplv3 366 80 proteins protein VBZ cord-309048-emmtplv3 366 81 Expression Expression NNP cord-309048-emmtplv3 366 82 of of IN cord-309048-emmtplv3 366 83 foot foot NN cord-309048-emmtplv3 366 84 - - HYPH cord-309048-emmtplv3 366 85 and and CC cord-309048-emmtplv3 366 86 - - HYPH cord-309048-emmtplv3 366 87 mouth mouth NN cord-309048-emmtplv3 366 88 disease disease NN cord-309048-emmtplv3 366 89 virus virus NN cord-309048-emmtplv3 366 90 epitopes epitope NNS cord-309048-emmtplv3 366 91 in in IN cord-309048-emmtplv3 366 92 tobacco tobacco NN cord-309048-emmtplv3 366 93 by by IN cord-309048-emmtplv3 366 94 a a DT cord-309048-emmtplv3 366 95 tobacco tobacco NN cord-309048-emmtplv3 366 96 mosaic mosaic NN cord-309048-emmtplv3 366 97 virus virus NN cord-309048-emmtplv3 366 98 - - HYPH cord-309048-emmtplv3 366 99 based base VBN cord-309048-emmtplv3 366 100 vector vector NN cord-309048-emmtplv3 366 101 Enhancing enhance VBG cord-309048-emmtplv3 366 102 the the DT cord-309048-emmtplv3 366 103 magnetoviscosity magnetoviscosity NN cord-309048-emmtplv3 366 104 of of IN cord-309048-emmtplv3 366 105 ferrofluids ferrofluid NNS cord-309048-emmtplv3 366 106 by by IN cord-309048-emmtplv3 366 107 the the DT cord-309048-emmtplv3 366 108 addition addition NN cord-309048-emmtplv3 366 109 of of IN cord-309048-emmtplv3 366 110 biological biological JJ cord-309048-emmtplv3 366 111 nanotubes nanotube NNS cord-309048-emmtplv3 367 1 Electrospinning electrospinning NN cord-309048-emmtplv3 367 2 fabrication fabrication NN cord-309048-emmtplv3 367 3 , , , cord-309048-emmtplv3 367 4 structural structural JJ cord-309048-emmtplv3 367 5 and and CC cord-309048-emmtplv3 367 6 mechanical mechanical JJ cord-309048-emmtplv3 367 7 characterization characterization NN cord-309048-emmtplv3 367 8 of of IN cord-309048-emmtplv3 367 9 rod rod NN cord-309048-emmtplv3 367 10 - - HYPH cord-309048-emmtplv3 367 11 like like JJ cord-309048-emmtplv3 367 12 virus virus NN cord-309048-emmtplv3 367 13 - - HYPH cord-309048-emmtplv3 367 14 based base VBN cord-309048-emmtplv3 367 15 composite composite JJ cord-309048-emmtplv3 367 16 nanofibers nanofiber NNS cord-309048-emmtplv3 367 17 Patterned pattern VBN cord-309048-emmtplv3 367 18 assembly assembly NN cord-309048-emmtplv3 367 19 of of IN cord-309048-emmtplv3 367 20 genetically genetically RB cord-309048-emmtplv3 367 21 modified modify VBN cord-309048-emmtplv3 367 22 viral viral JJ cord-309048-emmtplv3 367 23 nanotemplates nanotemplate NNS cord-309048-emmtplv3 367 24 via via IN cord-309048-emmtplv3 367 25 nucleic nucleic JJ cord-309048-emmtplv3 367 26 acid acid NN cord-309048-emmtplv3 367 27 hybridization hybridization NN cord-309048-emmtplv3 367 28 TMV TMV NNP cord-309048-emmtplv3 367 29 microarrays microarray NNS cord-309048-emmtplv3 367 30 : : : cord-309048-emmtplv3 367 31 hybridization hybridization NN cord-309048-emmtplv3 367 32 - - HYPH cord-309048-emmtplv3 367 33 based base VBN cord-309048-emmtplv3 367 34 assembly assembly NN cord-309048-emmtplv3 367 35 of of IN cord-309048-emmtplv3 367 36 DNA DNA NNP cord-309048-emmtplv3 367 37 - - HYPH cord-309048-emmtplv3 367 38 programmed program VBN cord-309048-emmtplv3 367 39 viral viral JJ cord-309048-emmtplv3 367 40 nanotemplates nanotemplates NNP cord-309048-emmtplv3 367 41 Tobacco Tobacco NNP cord-309048-emmtplv3 367 42 mosaic mosaic NNP cord-309048-emmtplv3 367 43 virus virus NN cord-309048-emmtplv3 367 44 replicase replicase NN cord-309048-emmtplv3 367 45 and and CC cord-309048-emmtplv3 367 46 replicative replicative JJ cord-309048-emmtplv3 367 47 structures structure NNS cord-309048-emmtplv3 367 48 Virus virus NN cord-309048-emmtplv3 367 49 - - HYPH cord-309048-emmtplv3 367 50 based base VBN cord-309048-emmtplv3 367 51 scaffolds scaffold NNS cord-309048-emmtplv3 367 52 for for IN cord-309048-emmtplv3 367 53 tissue tissue NN cord-309048-emmtplv3 367 54 engineering engineering NN cord-309048-emmtplv3 367 55 applications application NNS cord-309048-emmtplv3 367 56 Disulfide Disulfide NNP cord-309048-emmtplv3 367 57 bond bond NN cord-309048-emmtplv3 367 58 : : : cord-309048-emmtplv3 367 59 dramatically dramatically RB cord-309048-emmtplv3 367 60 enhanced enhance VBN cord-309048-emmtplv3 367 61 assembly assembly NN cord-309048-emmtplv3 367 62 capability capability NN cord-309048-emmtplv3 367 63 and and CC cord-309048-emmtplv3 367 64 structural structural JJ cord-309048-emmtplv3 367 65 stability stability NN cord-309048-emmtplv3 367 66 of of IN cord-309048-emmtplv3 367 67 tobacco tobacco NN cord-309048-emmtplv3 367 68 mosaic mosaic NN cord-309048-emmtplv3 367 69 virus virus NN cord-309048-emmtplv3 367 70 nanorods nanorods NNP cord-309048-emmtplv3 367 71 Site site NN cord-309048-emmtplv3 367 72 - - HYPH cord-309048-emmtplv3 367 73 selective selective JJ cord-309048-emmtplv3 367 74 nucleation nucleation NN cord-309048-emmtplv3 367 75 and and CC cord-309048-emmtplv3 367 76 controlled control VBN cord-309048-emmtplv3 367 77 growth growth NN cord-309048-emmtplv3 367 78 of of IN cord-309048-emmtplv3 367 79 gold gold JJ cord-309048-emmtplv3 367 80 nanostructures nanostructure NNS cord-309048-emmtplv3 367 81 in in IN cord-309048-emmtplv3 367 82 tobacco tobacco NN cord-309048-emmtplv3 367 83 mosaic mosaic NN cord-309048-emmtplv3 367 84 virus virus NN cord-309048-emmtplv3 367 85 nanotubulars nanotubulars NNP cord-309048-emmtplv3 368 1 The the DT cord-309048-emmtplv3 368 2 nucleotide nucleotide JJ cord-309048-emmtplv3 368 3 sequence sequence NN cord-309048-emmtplv3 368 4 at at IN cord-309048-emmtplv3 368 5 the the DT cord-309048-emmtplv3 368 6 origin origin NN cord-309048-emmtplv3 368 7 for for IN cord-309048-emmtplv3 368 8 assembly assembly NN cord-309048-emmtplv3 368 9 on on IN cord-309048-emmtplv3 368 10 tobacco tobacco NN cord-309048-emmtplv3 368 11 mosaic mosaic NNP cord-309048-emmtplv3 368 12 virus virus NN cord-309048-emmtplv3 368 13 RNA RNA NNP cord-309048-emmtplv3 369 1 The the DT cord-309048-emmtplv3 369 2 isolation isolation NN cord-309048-emmtplv3 369 3 of of IN cord-309048-emmtplv3 369 4 tobacco tobacco NN cord-309048-emmtplv3 369 5 mosaic mosaic NNP cord-309048-emmtplv3 369 6 virus virus NN cord-309048-emmtplv3 369 7 RNA rna NN cord-309048-emmtplv3 369 8 fragments fragment NNS cord-309048-emmtplv3 369 9 containing contain VBG cord-309048-emmtplv3 369 10 the the DT cord-309048-emmtplv3 369 11 origin origin NN cord-309048-emmtplv3 369 12 for for IN cord-309048-emmtplv3 369 13 viral viral JJ cord-309048-emmtplv3 369 14 assembly assembly NN cord-309048-emmtplv3 369 15 Location Location NNP cord-309048-emmtplv3 369 16 of of IN cord-309048-emmtplv3 369 17 the the DT cord-309048-emmtplv3 369 18 origin origin NN cord-309048-emmtplv3 369 19 for for IN cord-309048-emmtplv3 369 20 viral viral JJ cord-309048-emmtplv3 369 21 reassembly reassembly NN cord-309048-emmtplv3 369 22 on on IN cord-309048-emmtplv3 369 23 tobacco tobacco NN cord-309048-emmtplv3 369 24 mosaic mosaic NNP cord-309048-emmtplv3 369 25 virus virus NN cord-309048-emmtplv3 369 26 RNA RNA NNP cord-309048-emmtplv3 369 27 and and CC cord-309048-emmtplv3 369 28 its -PRON- PRP$ cord-309048-emmtplv3 369 29 relation relation NN cord-309048-emmtplv3 369 30 to to IN cord-309048-emmtplv3 369 31 stable stable JJ cord-309048-emmtplv3 369 32 fragment fragment NN