id sid tid token lemma pos cord-331066-ediowz4s 1 1 key key JJ cord-331066-ediowz4s 2 1 : : : cord-331066-ediowz4s 2 2 cord-331066-ediowz4s cord-331066-ediowz4s NN cord-331066-ediowz4s 2 3 authors author NNS cord-331066-ediowz4s 2 4 : : : cord-331066-ediowz4s 2 5 Chechetkin Chechetkin NNP cord-331066-ediowz4s 2 6 , , , cord-331066-ediowz4s 2 7 Vladimir Vladimir NNP cord-331066-ediowz4s 2 8 R. R. NNP cord-331066-ediowz4s 2 9 ; ; : cord-331066-ediowz4s 2 10 Lobzin Lobzin NNP cord-331066-ediowz4s 2 11 , , , cord-331066-ediowz4s 2 12 Vasily Vasily NNP cord-331066-ediowz4s 2 13 V. V. NNP cord-331066-ediowz4s 2 14 title title NN cord-331066-ediowz4s 2 15 : : : cord-331066-ediowz4s 2 16 Ribonucleocapsid Ribonucleocapsid NNP cord-331066-ediowz4s 2 17 assembly assembly NN cord-331066-ediowz4s 2 18 / / SYM cord-331066-ediowz4s 2 19 packaging packaging NN cord-331066-ediowz4s 2 20 signals signal NNS cord-331066-ediowz4s 2 21 in in IN cord-331066-ediowz4s 2 22 the the DT cord-331066-ediowz4s 2 23 genomes genome NNS cord-331066-ediowz4s 2 24 of of IN cord-331066-ediowz4s 2 25 the the DT cord-331066-ediowz4s 2 26 coronaviruses coronaviruse NNS cord-331066-ediowz4s 2 27 SARS SARS NNP cord-331066-ediowz4s 2 28 - - HYPH cord-331066-ediowz4s 2 29 CoV CoV NNP cord-331066-ediowz4s 2 30 and and CC cord-331066-ediowz4s 2 31 SARS SARS NNP cord-331066-ediowz4s 2 32 - - HYPH cord-331066-ediowz4s 2 33 CoV-2 CoV-2 NNP cord-331066-ediowz4s 2 34 : : : cord-331066-ediowz4s 2 35 detection detection NN cord-331066-ediowz4s 2 36 , , , cord-331066-ediowz4s 2 37 comparison comparison NN cord-331066-ediowz4s 2 38 and and CC cord-331066-ediowz4s 2 39 implications implication NNS cord-331066-ediowz4s 2 40 for for IN cord-331066-ediowz4s 2 41 therapeutic therapeutic JJ cord-331066-ediowz4s 2 42 targeting targeting NN cord-331066-ediowz4s 2 43 date date NN cord-331066-ediowz4s 2 44 : : : cord-331066-ediowz4s 2 45 2020 2020 CD cord-331066-ediowz4s 2 46 - - HYPH cord-331066-ediowz4s 2 47 09 09 CD cord-331066-ediowz4s 2 48 - - HYPH cord-331066-ediowz4s 2 49 09 09 CD cord-331066-ediowz4s 2 50 journal journal NN cord-331066-ediowz4s 2 51 : : : cord-331066-ediowz4s 2 52 Journal Journal NNP cord-331066-ediowz4s 2 53 of of IN cord-331066-ediowz4s 2 54 biomolecular biomolecular NNP cord-331066-ediowz4s 2 55 structure structure NN cord-331066-ediowz4s 2 56 & & CC cord-331066-ediowz4s 2 57 dynamics dynamic NNS cord-331066-ediowz4s 2 58 DOI DOI NNP cord-331066-ediowz4s 2 59 : : : cord-331066-ediowz4s 2 60 10.1080/07391102.2020.1815581 10.1080/07391102.2020.1815581 NNP cord-331066-ediowz4s 2 61 sha sha NNP cord-331066-ediowz4s 2 62 : : : cord-331066-ediowz4s 2 63 35fd809cbea32fc4752c1da8ee7f7980c0390e9c 35fd809cbea32fc4752c1da8ee7f7980c0390e9c CD cord-331066-ediowz4s 2 64 doc_id doc_id CD cord-331066-ediowz4s 2 65 : : : cord-331066-ediowz4s 3 1 331066 331066 CD cord-331066-ediowz4s 3 2 cord_uid cord_uid NNP cord-331066-ediowz4s 3 3 : : : cord-331066-ediowz4s 4 1 ediowz4s ediowz4s NNP cord-331066-ediowz4s 5 1 The the DT cord-331066-ediowz4s 5 2 genomic genomic NN cord-331066-ediowz4s 5 3 ssRNA ssrna NN cord-331066-ediowz4s 5 4 of of IN cord-331066-ediowz4s 5 5 coronaviruses coronaviruse NNS cord-331066-ediowz4s 5 6 is be VBZ cord-331066-ediowz4s 5 7 packaged package VBN cord-331066-ediowz4s 5 8 within within IN cord-331066-ediowz4s 5 9 a a DT cord-331066-ediowz4s 5 10 helical helical JJ cord-331066-ediowz4s 5 11 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 5 12 . . . cord-331066-ediowz4s 6 1 Due due IN cord-331066-ediowz4s 6 2 to to IN cord-331066-ediowz4s 6 3 transitional transitional JJ cord-331066-ediowz4s 6 4 symmetry symmetry NN cord-331066-ediowz4s 6 5 of of IN cord-331066-ediowz4s 6 6 a a DT cord-331066-ediowz4s 6 7 helix helix NN cord-331066-ediowz4s 6 8 , , , cord-331066-ediowz4s 6 9 weakly weakly RB cord-331066-ediowz4s 6 10 specific specific JJ cord-331066-ediowz4s 6 11 cooperative cooperative JJ cord-331066-ediowz4s 6 12 interaction interaction NN cord-331066-ediowz4s 6 13 between between IN cord-331066-ediowz4s 6 14 ssRNA ssrna NN cord-331066-ediowz4s 6 15 and and CC cord-331066-ediowz4s 6 16 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 6 17 proteins protein NNS cord-331066-ediowz4s 6 18 leads lead VBZ cord-331066-ediowz4s 6 19 to to IN cord-331066-ediowz4s 6 20 the the DT cord-331066-ediowz4s 6 21 natural natural JJ cord-331066-ediowz4s 6 22 selection selection NN cord-331066-ediowz4s 6 23 of of IN cord-331066-ediowz4s 6 24 specific specific JJ cord-331066-ediowz4s 6 25 quasi quasi JJ cord-331066-ediowz4s 6 26 - - JJ cord-331066-ediowz4s 6 27 periodic periodic JJ cord-331066-ediowz4s 6 28 assembly assembly NN cord-331066-ediowz4s 6 29 / / SYM cord-331066-ediowz4s 6 30 packaging packaging NN cord-331066-ediowz4s 6 31 signals signal NNS cord-331066-ediowz4s 6 32 in in IN cord-331066-ediowz4s 6 33 the the DT cord-331066-ediowz4s 6 34 related related JJ cord-331066-ediowz4s 6 35 genomic genomic JJ cord-331066-ediowz4s 6 36 sequence sequence NN cord-331066-ediowz4s 6 37 . . . cord-331066-ediowz4s 7 1 Such such JJ cord-331066-ediowz4s 7 2 signals signal NNS cord-331066-ediowz4s 7 3 coordinated coordinate VBN cord-331066-ediowz4s 7 4 with with IN cord-331066-ediowz4s 7 5 the the DT cord-331066-ediowz4s 7 6 nucleocapsid nucleocapsid NNP cord-331066-ediowz4s 7 7 helical helical JJ cord-331066-ediowz4s 7 8 structure structure NN cord-331066-ediowz4s 7 9 were be VBD cord-331066-ediowz4s 7 10 detected detect VBN cord-331066-ediowz4s 7 11 and and CC cord-331066-ediowz4s 7 12 reconstructed reconstruct VBN cord-331066-ediowz4s 7 13 in in IN cord-331066-ediowz4s 7 14 the the DT cord-331066-ediowz4s 7 15 genomes genome NNS cord-331066-ediowz4s 7 16 of of IN cord-331066-ediowz4s 7 17 the the DT cord-331066-ediowz4s 7 18 coronaviruses coronaviruse NNS cord-331066-ediowz4s 7 19 SARS SARS NNP cord-331066-ediowz4s 7 20 - - HYPH cord-331066-ediowz4s 7 21 CoV CoV NNP cord-331066-ediowz4s 7 22 and and CC cord-331066-ediowz4s 7 23 SARS SARS NNP cord-331066-ediowz4s 7 24 - - HYPH cord-331066-ediowz4s 7 25 CoV-2 CoV-2 NNP cord-331066-ediowz4s 7 26 . . . cord-331066-ediowz4s 8 1 The the DT cord-331066-ediowz4s 8 2 main main JJ cord-331066-ediowz4s 8 3 period period NN cord-331066-ediowz4s 8 4 of of IN cord-331066-ediowz4s 8 5 the the DT cord-331066-ediowz4s 8 6 signals signal NNS cord-331066-ediowz4s 8 7 for for IN cord-331066-ediowz4s 8 8 both both DT cord-331066-ediowz4s 8 9 viruses virus NNS cord-331066-ediowz4s 8 10 was be VBD cord-331066-ediowz4s 8 11 about about RB cord-331066-ediowz4s 8 12 54 54 CD cord-331066-ediowz4s 8 13 nt nt RB cord-331066-ediowz4s 8 14 , , , cord-331066-ediowz4s 8 15 that that WDT cord-331066-ediowz4s 8 16 implies imply VBZ cord-331066-ediowz4s 8 17 6.75 6.75 CD cord-331066-ediowz4s 8 18 nt nt RB cord-331066-ediowz4s 8 19 per per IN cord-331066-ediowz4s 8 20 N n NN cord-331066-ediowz4s 8 21 protein protein NN cord-331066-ediowz4s 8 22 . . . cord-331066-ediowz4s 9 1 The the DT cord-331066-ediowz4s 9 2 complete complete JJ cord-331066-ediowz4s 9 3 coverage coverage NN cord-331066-ediowz4s 9 4 of of IN cord-331066-ediowz4s 9 5 the the DT cord-331066-ediowz4s 9 6 ssRNA ssrna NN cord-331066-ediowz4s 9 7 genome genome NN cord-331066-ediowz4s 9 8 of of IN cord-331066-ediowz4s 9 9 length length NN cord-331066-ediowz4s 9 10 about about RB cord-331066-ediowz4s 9 11 30,000 30,000 CD cord-331066-ediowz4s 9 12 nt nt RB cord-331066-ediowz4s 9 13 by by IN cord-331066-ediowz4s 9 14 the the DT cord-331066-ediowz4s 9 15 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 9 16 would would MD cord-331066-ediowz4s 9 17 need need VB cord-331066-ediowz4s 9 18 4.4 4.4 CD cord-331066-ediowz4s 9 19 × × NNP cord-331066-ediowz4s 9 20 10(3 10(3 CD cord-331066-ediowz4s 9 21 ) ) -RRB- cord-331066-ediowz4s 10 1 N n NN cord-331066-ediowz4s 10 2 proteins protein NNS cord-331066-ediowz4s 10 3 , , , cord-331066-ediowz4s 11 1 that that DT cord-331066-ediowz4s 11 2 makes make VBZ cord-331066-ediowz4s 11 3 them -PRON- PRP cord-331066-ediowz4s 11 4 the the DT cord-331066-ediowz4s 11 5 most most RBS cord-331066-ediowz4s 11 6 abundant abundant JJ cord-331066-ediowz4s 11 7 among among IN cord-331066-ediowz4s 11 8 the the DT cord-331066-ediowz4s 11 9 structural structural JJ cord-331066-ediowz4s 11 10 proteins protein NNS cord-331066-ediowz4s 11 11 . . . cord-331066-ediowz4s 12 1 The the DT cord-331066-ediowz4s 12 2 repertoires repertoire NNS cord-331066-ediowz4s 12 3 of of IN cord-331066-ediowz4s 12 4 motifs motif NNS cord-331066-ediowz4s 12 5 for for IN cord-331066-ediowz4s 12 6 SARS SARS NNP cord-331066-ediowz4s 12 7 - - HYPH cord-331066-ediowz4s 12 8 CoV CoV NNP cord-331066-ediowz4s 12 9 and and CC cord-331066-ediowz4s 12 10 SARS SARS NNP cord-331066-ediowz4s 12 11 - - HYPH cord-331066-ediowz4s 12 12 CoV-2 CoV-2 NNP cord-331066-ediowz4s 12 13 were be VBD cord-331066-ediowz4s 12 14 divergent divergent JJ cord-331066-ediowz4s 12 15 but but CC cord-331066-ediowz4s 12 16 nearly nearly RB cord-331066-ediowz4s 12 17 coincided coincide VBD cord-331066-ediowz4s 12 18 for for IN cord-331066-ediowz4s 12 19 different different JJ cord-331066-ediowz4s 12 20 isolates isolate NNS cord-331066-ediowz4s 12 21 of of IN cord-331066-ediowz4s 12 22 SARS SARS NNP cord-331066-ediowz4s 12 23 - - HYPH cord-331066-ediowz4s 12 24 CoV-2 CoV-2 NNP cord-331066-ediowz4s 12 25 . . . cord-331066-ediowz4s 13 1 We -PRON- PRP cord-331066-ediowz4s 13 2 obtained obtain VBD cord-331066-ediowz4s 13 3 the the DT cord-331066-ediowz4s 13 4 distributions distribution NNS cord-331066-ediowz4s 13 5 of of IN cord-331066-ediowz4s 13 6 assembly assembly NN cord-331066-ediowz4s 13 7 / / SYM cord-331066-ediowz4s 13 8 packaging packaging NN cord-331066-ediowz4s 13 9 signals signal NNS cord-331066-ediowz4s 13 10 over over IN cord-331066-ediowz4s 13 11 the the DT cord-331066-ediowz4s 13 12 genomes genome NNS cord-331066-ediowz4s 13 13 with with IN cord-331066-ediowz4s 13 14 nonoverlapping nonoverlappe VBG cord-331066-ediowz4s 13 15 windows window NNS cord-331066-ediowz4s 13 16 of of IN cord-331066-ediowz4s 13 17 width width NN cord-331066-ediowz4s 13 18 432 432 CD cord-331066-ediowz4s 13 19 nt nt RB cord-331066-ediowz4s 13 20 . . . cord-331066-ediowz4s 14 1 Finally finally RB cord-331066-ediowz4s 14 2 , , , cord-331066-ediowz4s 14 3 using use VBG cord-331066-ediowz4s 14 4 the the DT cord-331066-ediowz4s 14 5 spectral spectral JJ cord-331066-ediowz4s 14 6 entropy entropy NN cord-331066-ediowz4s 14 7 , , , cord-331066-ediowz4s 14 8 we -PRON- PRP cord-331066-ediowz4s 14 9 compared compare VBD cord-331066-ediowz4s 14 10 the the DT cord-331066-ediowz4s 14 11 load load NN cord-331066-ediowz4s 14 12 from from IN cord-331066-ediowz4s 14 13 point point NN cord-331066-ediowz4s 14 14 mutations mutation NNS cord-331066-ediowz4s 14 15 and and CC cord-331066-ediowz4s 14 16 indels indel NNS cord-331066-ediowz4s 14 17 during during IN cord-331066-ediowz4s 14 18 virus virus NN cord-331066-ediowz4s 14 19 age age NN cord-331066-ediowz4s 14 20 for for IN cord-331066-ediowz4s 14 21 SARS SARS NNP cord-331066-ediowz4s 14 22 - - HYPH cord-331066-ediowz4s 14 23 CoV CoV NNP cord-331066-ediowz4s 14 24 and and CC cord-331066-ediowz4s 14 25 SARS SARS NNP cord-331066-ediowz4s 14 26 - - HYPH cord-331066-ediowz4s 14 27 CoV-2 CoV-2 NNP cord-331066-ediowz4s 14 28 . . . cord-331066-ediowz4s 15 1 We -PRON- PRP cord-331066-ediowz4s 15 2 found find VBD cord-331066-ediowz4s 15 3 the the DT cord-331066-ediowz4s 15 4 higher high JJR cord-331066-ediowz4s 15 5 mutational mutational JJ cord-331066-ediowz4s 15 6 load load NN cord-331066-ediowz4s 15 7 on on IN cord-331066-ediowz4s 15 8 SARS SARS NNP cord-331066-ediowz4s 15 9 - - HYPH cord-331066-ediowz4s 15 10 CoV. CoV. NNP cord-331066-ediowz4s 16 1 In in IN cord-331066-ediowz4s 16 2 this this DT cord-331066-ediowz4s 16 3 sense sense NN cord-331066-ediowz4s 16 4 , , , cord-331066-ediowz4s 16 5 SARS SARS NNP cord-331066-ediowz4s 16 6 - - HYPH cord-331066-ediowz4s 16 7 CoV-2 CoV-2 NNP cord-331066-ediowz4s 16 8 can can MD cord-331066-ediowz4s 16 9 be be VB cord-331066-ediowz4s 16 10 treated treat VBN cord-331066-ediowz4s 16 11 as as IN cord-331066-ediowz4s 16 12 a a DT cord-331066-ediowz4s 16 13 ‘ ' `` cord-331066-ediowz4s 16 14 newborn newborn JJ cord-331066-ediowz4s 16 15 ’ ' '' cord-331066-ediowz4s 16 16 virus virus NN cord-331066-ediowz4s 16 17 . . . cord-331066-ediowz4s 17 1 These these DT cord-331066-ediowz4s 17 2 observations observation NNS cord-331066-ediowz4s 17 3 may may MD cord-331066-ediowz4s 17 4 be be VB cord-331066-ediowz4s 17 5 helpful helpful JJ cord-331066-ediowz4s 17 6 in in IN cord-331066-ediowz4s 17 7 practical practical JJ cord-331066-ediowz4s 17 8 medical medical JJ cord-331066-ediowz4s 17 9 applications application NNS cord-331066-ediowz4s 17 10 and and CC cord-331066-ediowz4s 17 11 are be VBP cord-331066-ediowz4s 17 12 of of IN cord-331066-ediowz4s 17 13 basic basic JJ cord-331066-ediowz4s 17 14 interest interest NN cord-331066-ediowz4s 17 15 . . . cord-331066-ediowz4s 18 1 Communicated communicate VBN cord-331066-ediowz4s 18 2 by by IN cord-331066-ediowz4s 18 3 Ramaswamy Ramaswamy NNP cord-331066-ediowz4s 18 4 H. H. NNP cord-331066-ediowz4s 18 5 Sarma Sarma NNP cord-331066-ediowz4s 18 6 To to IN cord-331066-ediowz4s 18 7 the the DT cord-331066-ediowz4s 18 8 end end NN cord-331066-ediowz4s 18 9 of of IN cord-331066-ediowz4s 18 10 July July NNP cord-331066-ediowz4s 18 11 2020 2020 CD cord-331066-ediowz4s 18 12 , , , cord-331066-ediowz4s 18 13 the the DT cord-331066-ediowz4s 18 14 COVID-19 COVID-19 NNP cord-331066-ediowz4s 18 15 pandemia pandemia NN cord-331066-ediowz4s 18 16 was be VBD cord-331066-ediowz4s 18 17 the the DT cord-331066-ediowz4s 18 18 cause cause NN cord-331066-ediowz4s 18 19 of of IN cord-331066-ediowz4s 18 20 more more JJR cord-331066-ediowz4s 18 21 than than IN cord-331066-ediowz4s 18 22 18.4 18.4 CD cord-331066-ediowz4s 18 23 million million CD cord-331066-ediowz4s 18 24 of of IN cord-331066-ediowz4s 18 25 coronavirus coronavirus NN cord-331066-ediowz4s 18 26 cases case NNS cord-331066-ediowz4s 18 27 and and CC cord-331066-ediowz4s 18 28 more more JJR cord-331066-ediowz4s 18 29 than than IN cord-331066-ediowz4s 18 30 695,000 695,000 CD cord-331066-ediowz4s 18 31 of of IN cord-331066-ediowz4s 18 32 deaths death NNS cord-331066-ediowz4s 18 33 over over IN cord-331066-ediowz4s 18 34 all all DT cord-331066-ediowz4s 18 35 world world NN cord-331066-ediowz4s 18 36 ( ( -LRB- cord-331066-ediowz4s 18 37 https://www https://www . cord-331066-ediowz4s 18 38 . . . cord-331066-ediowz4s 18 39 worldometers.info/coronavirus/ worldometers.info/coronavirus/ NNP cord-331066-ediowz4s 18 40 ) ) -RRB- cord-331066-ediowz4s 18 41 . . . cord-331066-ediowz4s 19 1 The the DT cord-331066-ediowz4s 19 2 pandemia pandemia NN cord-331066-ediowz4s 19 3 is be VBZ cord-331066-ediowz4s 19 4 still still RB cord-331066-ediowz4s 19 5 continuing continue VBG cord-331066-ediowz4s 19 6 and and CC cord-331066-ediowz4s 19 7 the the DT cord-331066-ediowz4s 19 8 possibility possibility NN cord-331066-ediowz4s 19 9 of of IN cord-331066-ediowz4s 19 10 return return NN cord-331066-ediowz4s 19 11 of of IN cord-331066-ediowz4s 19 12 new new JJ cord-331066-ediowz4s 19 13 disease disease NN cord-331066-ediowz4s 19 14 waves wave NNS cord-331066-ediowz4s 19 15 is be VBZ cord-331066-ediowz4s 19 16 considered consider VBN cord-331066-ediowz4s 19 17 to to TO cord-331066-ediowz4s 19 18 be be VB cord-331066-ediowz4s 19 19 very very RB cord-331066-ediowz4s 19 20 high high JJ cord-331066-ediowz4s 19 21 . . . cord-331066-ediowz4s 20 1 The the DT cord-331066-ediowz4s 20 2 development development NN cord-331066-ediowz4s 20 3 of of IN cord-331066-ediowz4s 20 4 efficient efficient JJ cord-331066-ediowz4s 20 5 medications medication NNS cord-331066-ediowz4s 20 6 and and CC cord-331066-ediowz4s 20 7 vaccines vaccine NNS cord-331066-ediowz4s 20 8 against against IN cord-331066-ediowz4s 20 9 coronaviruses coronaviruse NNS cord-331066-ediowz4s 20 10 needs need VBZ cord-331066-ediowz4s 20 11 the the DT cord-331066-ediowz4s 20 12 knowledge knowledge NN cord-331066-ediowz4s 20 13 of of IN cord-331066-ediowz4s 20 14 main main JJ cord-331066-ediowz4s 20 15 molecular molecular JJ cord-331066-ediowz4s 20 16 mechanisms mechanism NNS cord-331066-ediowz4s 20 17 in in IN cord-331066-ediowz4s 20 18 the the DT cord-331066-ediowz4s 20 19 virus virus NN cord-331066-ediowz4s 20 20 life life NN cord-331066-ediowz4s 20 21 cycle cycle NN cord-331066-ediowz4s 20 22 and and CC cord-331066-ediowz4s 20 23 virus virus NN cord-331066-ediowz4s 20 24 - - HYPH cord-331066-ediowz4s 20 25 host host NN cord-331066-ediowz4s 20 26 interaction interaction NN cord-331066-ediowz4s 21 1 ( ( -LRB- cord-331066-ediowz4s 21 2 Feng Feng NNP cord-331066-ediowz4s 21 3 et et FW cord-331066-ediowz4s 21 4 al al NNP cord-331066-ediowz4s 21 5 . . . cord-331066-ediowz4s 22 1 , , , cord-331066-ediowz4s 22 2 2020 2020 CD cord-331066-ediowz4s 22 3 ; ; : cord-331066-ediowz4s 22 4 Fung Fung NNP cord-331066-ediowz4s 22 5 & & CC cord-331066-ediowz4s 22 6 Liu Liu NNP cord-331066-ediowz4s 22 7 , , , cord-331066-ediowz4s 22 8 2019 2019 CD cord-331066-ediowz4s 22 9 ; ; : cord-331066-ediowz4s 22 10 Maier Maier NNP cord-331066-ediowz4s 22 11 et et NNP cord-331066-ediowz4s 22 12 al al NNP cord-331066-ediowz4s 22 13 . . NNP cord-331066-ediowz4s 22 14 , , , cord-331066-ediowz4s 22 15 2015 2015 CD cord-331066-ediowz4s 22 16 ; ; : cord-331066-ediowz4s 22 17 Saxena Saxena NNP cord-331066-ediowz4s 22 18 , , , cord-331066-ediowz4s 22 19 2020 2020 CD cord-331066-ediowz4s 22 20 ; ; : cord-331066-ediowz4s 22 21 Xie Xie NNP cord-331066-ediowz4s 22 22 & & CC cord-331066-ediowz4s 22 23 Chen Chen NNP cord-331066-ediowz4s 22 24 , , , cord-331066-ediowz4s 22 25 2020 2020 CD cord-331066-ediowz4s 22 26 ; ; : cord-331066-ediowz4s 22 27 Ziebuhr Ziebuhr NNP cord-331066-ediowz4s 22 28 , , , cord-331066-ediowz4s 22 29 2016 2016 CD cord-331066-ediowz4s 22 30 ) ) -RRB- cord-331066-ediowz4s 22 31 . . . cord-331066-ediowz4s 23 1 In in IN cord-331066-ediowz4s 23 2 this this DT cord-331066-ediowz4s 23 3 article article NN cord-331066-ediowz4s 23 4 , , , cord-331066-ediowz4s 23 5 we -PRON- PRP cord-331066-ediowz4s 23 6 will will MD cord-331066-ediowz4s 23 7 discuss discuss VB cord-331066-ediowz4s 23 8 a a DT cord-331066-ediowz4s 23 9 specific specific JJ cord-331066-ediowz4s 23 10 interaction interaction NN cord-331066-ediowz4s 23 11 between between IN cord-331066-ediowz4s 23 12 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 23 13 ( ( -LRB- cord-331066-ediowz4s 23 14 N N NNP cord-331066-ediowz4s 23 15 ) ) -RRB- cord-331066-ediowz4s 23 16 proteins protein NNS cord-331066-ediowz4s 23 17 and and CC cord-331066-ediowz4s 23 18 genomic genomic JJ cord-331066-ediowz4s 23 19 ssRNA ssRNA '' cord-331066-ediowz4s 24 1 in in IN cord-331066-ediowz4s 24 2 the the DT cord-331066-ediowz4s 24 3 coronaviruses coronaviruse NNS cord-331066-ediowz4s 24 4 SARS SARS NNP cord-331066-ediowz4s 24 5 - - HYPH cord-331066-ediowz4s 24 6 CoV CoV NNP cord-331066-ediowz4s 24 7 and and CC cord-331066-ediowz4s 24 8 SARS SARS NNP cord-331066-ediowz4s 24 9 - - HYPH cord-331066-ediowz4s 24 10 CoV-2 CoV-2 NNP cord-331066-ediowz4s 24 11 . . . cord-331066-ediowz4s 25 1 The the DT cord-331066-ediowz4s 25 2 ssRNA ssRNA VBG cord-331066-ediowz4s 25 3 genome genome NN cord-331066-ediowz4s 25 4 of of IN cord-331066-ediowz4s 25 5 the the DT cord-331066-ediowz4s 25 6 coronaviruses coronaviruse NNS cord-331066-ediowz4s 25 7 is be VBZ cord-331066-ediowz4s 25 8 packaged package VBN cord-331066-ediowz4s 25 9 within within IN cord-331066-ediowz4s 25 10 a a DT cord-331066-ediowz4s 25 11 helical helical JJ cord-331066-ediowz4s 25 12 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 25 13 , , , cord-331066-ediowz4s 25 14 while while IN cord-331066-ediowz4s 25 15 the the DT cord-331066-ediowz4s 25 16 whole whole JJ cord-331066-ediowz4s 25 17 ribonucleocapsid ribonucleocapsid NNP cord-331066-ediowz4s 25 18 is be VBZ cord-331066-ediowz4s 25 19 packaged package VBN cord-331066-ediowz4s 25 20 within within IN cord-331066-ediowz4s 25 21 a a DT cord-331066-ediowz4s 25 22 membrane membrane NN cord-331066-ediowz4s 25 23 envelope envelope NN cord-331066-ediowz4s 25 24 ( ( -LRB- cord-331066-ediowz4s 25 25 for for IN cord-331066-ediowz4s 25 26 a a DT cord-331066-ediowz4s 25 27 review review NN cord-331066-ediowz4s 25 28 see see NN cord-331066-ediowz4s 25 29 , , , cord-331066-ediowz4s 25 30 e.g. e.g. RB cord-331066-ediowz4s 25 31 Masters Masters NNPS cord-331066-ediowz4s 25 32 , , , cord-331066-ediowz4s 25 33 2019 2019 CD cord-331066-ediowz4s 25 34 ; ; : cord-331066-ediowz4s 25 35 Neuman Neuman NNP cord-331066-ediowz4s 25 36 & & CC cord-331066-ediowz4s 25 37 Buchmeier Buchmeier NNP cord-331066-ediowz4s 25 38 , , , cord-331066-ediowz4s 25 39 2016 2016 CD cord-331066-ediowz4s 25 40 ) ) -RRB- cord-331066-ediowz4s 25 41 . . . cord-331066-ediowz4s 26 1 The the DT cord-331066-ediowz4s 26 2 term term NN cord-331066-ediowz4s 26 3 ' ' '' cord-331066-ediowz4s 26 4 packaging packaging NN cord-331066-ediowz4s 26 5 signal signal NN cord-331066-ediowz4s 26 6 ' ' '' cord-331066-ediowz4s 26 7 in in IN cord-331066-ediowz4s 26 8 the the DT cord-331066-ediowz4s 26 9 coronavirus coronavirus NN cord-331066-ediowz4s 26 10 papers paper NNS cord-331066-ediowz4s 26 11 is be VBZ cord-331066-ediowz4s 26 12 overwhelmingly overwhelmingly RB cord-331066-ediowz4s 26 13 attributed attribute VBN cord-331066-ediowz4s 26 14 to to IN cord-331066-ediowz4s 26 15 the the DT cord-331066-ediowz4s 26 16 specific specific JJ cord-331066-ediowz4s 26 17 interaction interaction NN cord-331066-ediowz4s 26 18 between between IN cord-331066-ediowz4s 26 19 the the DT cord-331066-ediowz4s 26 20 genomic genomic JJ cord-331066-ediowz4s 26 21 RNA rna NN cord-331066-ediowz4s 26 22 and and CC cord-331066-ediowz4s 26 23 membrane membrane NN cord-331066-ediowz4s 26 24 ( ( -LRB- cord-331066-ediowz4s 26 25 M M NNP cord-331066-ediowz4s 26 26 ) ) -RRB- cord-331066-ediowz4s 26 27 proteins protein NNS cord-331066-ediowz4s 26 28 ensuring ensure VBG cord-331066-ediowz4s 26 29 the the DT cord-331066-ediowz4s 26 30 transport transport NN cord-331066-ediowz4s 26 31 of of IN cord-331066-ediowz4s 26 32 the the DT cord-331066-ediowz4s 26 33 ribonucleocapsid ribonucleocapsid NN cord-331066-ediowz4s 26 34 into into IN cord-331066-ediowz4s 26 35 the the DT cord-331066-ediowz4s 26 36 membrane membrane NN cord-331066-ediowz4s 26 37 envelope envelope NN cord-331066-ediowz4s 26 38 ( ( -LRB- cord-331066-ediowz4s 26 39 Fosmire Fosmire NNP cord-331066-ediowz4s 26 40 et et NNP cord-331066-ediowz4s 26 41 al al NNP cord-331066-ediowz4s 26 42 . . NNP cord-331066-ediowz4s 26 43 , , , cord-331066-ediowz4s 26 44 1992 1992 CD cord-331066-ediowz4s 26 45 ; ; : cord-331066-ediowz4s 26 46 Madhugiri Madhugiri NNP cord-331066-ediowz4s 26 47 et et NNP cord-331066-ediowz4s 26 48 al al NNP cord-331066-ediowz4s 26 49 . . NNP cord-331066-ediowz4s 26 50 , , , cord-331066-ediowz4s 26 51 2016 2016 CD cord-331066-ediowz4s 26 52 ; ; : cord-331066-ediowz4s 26 53 Masters master NNS cord-331066-ediowz4s 26 54 , , , cord-331066-ediowz4s 26 55 2019 2019 CD cord-331066-ediowz4s 26 56 ; ; : cord-331066-ediowz4s 26 57 Narayanan Narayanan NNP cord-331066-ediowz4s 26 58 , , , cord-331066-ediowz4s 26 59 & & CC cord-331066-ediowz4s 26 60 Makino Makino NNP cord-331066-ediowz4s 26 61 , , , cord-331066-ediowz4s 26 62 2001 2001 CD cord-331066-ediowz4s 26 63 ; ; : cord-331066-ediowz4s 26 64 Woo Woo NNP cord-331066-ediowz4s 26 65 et et NNP cord-331066-ediowz4s 26 66 al al NNP cord-331066-ediowz4s 26 67 . . NNP cord-331066-ediowz4s 26 68 , , , cord-331066-ediowz4s 26 69 2019 2019 CD cord-331066-ediowz4s 26 70 ) ) -RRB- cord-331066-ediowz4s 26 71 . . . cord-331066-ediowz4s 27 1 The the DT cord-331066-ediowz4s 27 2 interactions interaction NNS cord-331066-ediowz4s 27 3 between between IN cord-331066-ediowz4s 27 4 genomic genomic JJ cord-331066-ediowz4s 27 5 RNA RNA NNP cord-331066-ediowz4s 27 6 and and CC cord-331066-ediowz4s 27 7 N n CD cord-331066-ediowz4s 27 8 proteins protein NNS cord-331066-ediowz4s 27 9 are be VBP cord-331066-ediowz4s 27 10 assumed assume VBN cord-331066-ediowz4s 27 11 to to TO cord-331066-ediowz4s 27 12 be be VB cord-331066-ediowz4s 27 13 nonspecific nonspecific JJ cord-331066-ediowz4s 27 14 and and CC cord-331066-ediowz4s 27 15 governed govern VBN cord-331066-ediowz4s 27 16 mainly mainly RB cord-331066-ediowz4s 27 17 by by IN cord-331066-ediowz4s 27 18 electrostatic electrostatic JJ cord-331066-ediowz4s 27 19 effects effect NNS cord-331066-ediowz4s 27 20 . . . cord-331066-ediowz4s 28 1 The the DT cord-331066-ediowz4s 28 2 question question NN cord-331066-ediowz4s 28 3 of of IN cord-331066-ediowz4s 28 4 how how WRB cord-331066-ediowz4s 28 5 N n CD cord-331066-ediowz4s 28 6 proteins protein NNS cord-331066-ediowz4s 28 7 recognize recognize VBP cord-331066-ediowz4s 28 8 the the DT cord-331066-ediowz4s 28 9 related related JJ cord-331066-ediowz4s 28 10 genomic genomic JJ cord-331066-ediowz4s 28 11 RNA RNA NNP cord-331066-ediowz4s 28 12 remains remain VBZ cord-331066-ediowz4s 28 13 unanswered unanswered JJ cord-331066-ediowz4s 28 14 . . . cord-331066-ediowz4s 29 1 A a DT cord-331066-ediowz4s 29 2 similar similar JJ cord-331066-ediowz4s 29 3 point point NN cord-331066-ediowz4s 29 4 of of IN cord-331066-ediowz4s 29 5 view view NN cord-331066-ediowz4s 29 6 was be VBD cord-331066-ediowz4s 29 7 long long RB cord-331066-ediowz4s 29 8 - - HYPH cord-331066-ediowz4s 29 9 lastingly lastingly RB cord-331066-ediowz4s 29 10 prevalent prevalent JJ cord-331066-ediowz4s 29 11 also also RB cord-331066-ediowz4s 29 12 in in IN cord-331066-ediowz4s 29 13 the the DT cord-331066-ediowz4s 29 14 virology virology NN cord-331066-ediowz4s 29 15 community community NN cord-331066-ediowz4s 29 16 which which WDT cord-331066-ediowz4s 29 17 studied study VBD cord-331066-ediowz4s 29 18 ssRNA ssrna NN cord-331066-ediowz4s 29 19 viruses virus NNS cord-331066-ediowz4s 29 20 with with IN cord-331066-ediowz4s 29 21 icosahedral icosahedral JJ cord-331066-ediowz4s 29 22 capsids capsid NNS cord-331066-ediowz4s 29 23 . . . cord-331066-ediowz4s 30 1 The the DT cord-331066-ediowz4s 30 2 importance importance NN cord-331066-ediowz4s 30 3 of of IN cord-331066-ediowz4s 30 4 cooperative cooperative JJ cord-331066-ediowz4s 30 5 weakly weakly RB cord-331066-ediowz4s 30 6 specific specific JJ cord-331066-ediowz4s 30 7 interactions interaction NNS cord-331066-ediowz4s 30 8 between between IN cord-331066-ediowz4s 30 9 ssRNA ssrna NN cord-331066-ediowz4s 30 10 and and CC cord-331066-ediowz4s 30 11 capsid capsid NN cord-331066-ediowz4s 30 12 proteins protein NNS cord-331066-ediowz4s 30 13 has have VBZ cord-331066-ediowz4s 30 14 been be VBN cord-331066-ediowz4s 30 15 recognized recognize VBN cord-331066-ediowz4s 30 16 not not RB cord-331066-ediowz4s 30 17 long long RB cord-331066-ediowz4s 30 18 ago ago RB cord-331066-ediowz4s 30 19 ( ( -LRB- cord-331066-ediowz4s 30 20 see see VB cord-331066-ediowz4s 30 21 discussion discussion NN cord-331066-ediowz4s 30 22 by by IN cord-331066-ediowz4s 30 23 Twarock Twarock NNP cord-331066-ediowz4s 30 24 et et NNP cord-331066-ediowz4s 30 25 al al NNP cord-331066-ediowz4s 30 26 . . . cord-331066-ediowz4s 31 1 ( ( -LRB- cord-331066-ediowz4s 31 2 2018 2018 CD cord-331066-ediowz4s 31 3 ) ) -RRB- cord-331066-ediowz4s 31 4 and and CC cord-331066-ediowz4s 31 5 references reference NNS cord-331066-ediowz4s 31 6 therein therein RB cord-331066-ediowz4s 31 7 ) ) -RRB- cord-331066-ediowz4s 31 8 . . . cord-331066-ediowz4s 32 1 Stockley Stockley NNP cord-331066-ediowz4s 32 2 et et FW cord-331066-ediowz4s 32 3 al al NNP cord-331066-ediowz4s 32 4 . . . cord-331066-ediowz4s 33 1 ( ( -LRB- cord-331066-ediowz4s 33 2 2016 2016 CD cord-331066-ediowz4s 33 3 ) ) -RRB- cord-331066-ediowz4s 33 4 suggested suggest VBD cord-331066-ediowz4s 33 5 and and CC cord-331066-ediowz4s 33 6 proved prove VBD cord-331066-ediowz4s 33 7 experimentally experimentally RB cord-331066-ediowz4s 33 8 a a DT cord-331066-ediowz4s 33 9 two two CD cord-331066-ediowz4s 33 10 - - HYPH cord-331066-ediowz4s 33 11 stage stage NN cord-331066-ediowz4s 33 12 model model NN cord-331066-ediowz4s 33 13 for for IN cord-331066-ediowz4s 33 14 the the DT cord-331066-ediowz4s 33 15 assembly assembly NN cord-331066-ediowz4s 33 16 of of IN cord-331066-ediowz4s 33 17 ssRNA ssRNA `` cord-331066-ediowz4s 33 18 viruses virus NNS cord-331066-ediowz4s 33 19 with with IN cord-331066-ediowz4s 33 20 icosahedral icosahedral JJ cord-331066-ediowz4s 33 21 capsids capsid NNS cord-331066-ediowz4s 33 22 . . . cord-331066-ediowz4s 34 1 At at IN cord-331066-ediowz4s 34 2 the the DT cord-331066-ediowz4s 34 3 first first JJ cord-331066-ediowz4s 34 4 , , , cord-331066-ediowz4s 34 5 more more RBR cord-331066-ediowz4s 34 6 rapid rapid JJ cord-331066-ediowz4s 34 7 , , , cord-331066-ediowz4s 34 8 stage stage NN cord-331066-ediowz4s 34 9 RNA RNA NNP cord-331066-ediowz4s 34 10 binds bind VBZ cord-331066-ediowz4s 34 11 to to IN cord-331066-ediowz4s 34 12 the the DT cord-331066-ediowz4s 34 13 coat coat NN cord-331066-ediowz4s 34 14 proteins protein NNS cord-331066-ediowz4s 34 15 to to TO cord-331066-ediowz4s 34 16 facilitate facilitate VB cord-331066-ediowz4s 34 17 capsid capsid NN cord-331066-ediowz4s 34 18 assembly assembly NN cord-331066-ediowz4s 34 19 , , , cord-331066-ediowz4s 34 20 whereas whereas IN cord-331066-ediowz4s 34 21 at at IN cord-331066-ediowz4s 34 22 the the DT cord-331066-ediowz4s 34 23 second second JJ cord-331066-ediowz4s 34 24 , , , cord-331066-ediowz4s 34 25 slower slow JJR cord-331066-ediowz4s 34 26 , , , cord-331066-ediowz4s 34 27 stage stage NN cord-331066-ediowz4s 34 28 RNA RNA NNP cord-331066-ediowz4s 34 29 is be VBZ cord-331066-ediowz4s 34 30 compactly compactly RB cord-331066-ediowz4s 34 31 packaged package VBN cord-331066-ediowz4s 34 32 within within IN cord-331066-ediowz4s 34 33 the the DT cord-331066-ediowz4s 34 34 capsid capsid NN cord-331066-ediowz4s 34 35 . . . cord-331066-ediowz4s 35 1 The the DT cord-331066-ediowz4s 35 2 specific specific JJ cord-331066-ediowz4s 35 3 cooperative cooperative JJ cord-331066-ediowz4s 35 4 RNA rna NN cord-331066-ediowz4s 35 5 - - HYPH cord-331066-ediowz4s 35 6 coat coat NN cord-331066-ediowz4s 35 7 protein protein NN cord-331066-ediowz4s 35 8 interactions interaction NNS cord-331066-ediowz4s 35 9 play play VBP cord-331066-ediowz4s 35 10 important important JJ cord-331066-ediowz4s 35 11 role role NN cord-331066-ediowz4s 35 12 at at IN cord-331066-ediowz4s 35 13 the the DT cord-331066-ediowz4s 35 14 both both DT cord-331066-ediowz4s 35 15 stages stage NNS cord-331066-ediowz4s 35 16 . . . cord-331066-ediowz4s 36 1 The the DT cord-331066-ediowz4s 36 2 two two CD cord-331066-ediowz4s 36 3 stages stage NNS cord-331066-ediowz4s 36 4 may may MD cord-331066-ediowz4s 36 5 be be VB cord-331066-ediowz4s 36 6 associated associate VBN cord-331066-ediowz4s 36 7 with with IN cord-331066-ediowz4s 36 8 different different JJ cord-331066-ediowz4s 36 9 signals signal NNS cord-331066-ediowz4s 36 10 ( ( -LRB- cord-331066-ediowz4s 36 11 Chechetkin Chechetkin NNP cord-331066-ediowz4s 36 12 & & CC cord-331066-ediowz4s 36 13 Lobzin Lobzin NNP cord-331066-ediowz4s 36 14 , , , cord-331066-ediowz4s 36 15 2019 2019 CD cord-331066-ediowz4s 36 16 ) ) -RRB- cord-331066-ediowz4s 36 17 and and CC cord-331066-ediowz4s 36 18 the the DT cord-331066-ediowz4s 36 19 whole whole JJ cord-331066-ediowz4s 36 20 dynamic dynamic JJ cord-331066-ediowz4s 36 21 process process NN cord-331066-ediowz4s 36 22 may may MD cord-331066-ediowz4s 36 23 be be VB cord-331066-ediowz4s 36 24 called call VBN cord-331066-ediowz4s 36 25 assembly assembly NN cord-331066-ediowz4s 36 26 / / SYM cord-331066-ediowz4s 36 27 packaging packaging NN cord-331066-ediowz4s 36 28 . . . cord-331066-ediowz4s 37 1 The the DT cord-331066-ediowz4s 37 2 generalization generalization NN cord-331066-ediowz4s 37 3 of of IN cord-331066-ediowz4s 37 4 these these DT cord-331066-ediowz4s 37 5 ideas idea NNS cord-331066-ediowz4s 37 6 on on IN cord-331066-ediowz4s 37 7 viruses virus NNS cord-331066-ediowz4s 37 8 with with IN cord-331066-ediowz4s 37 9 ribonucleocapsid ribonucleocapsid NNP cord-331066-ediowz4s 37 10 within within IN cord-331066-ediowz4s 37 11 the the DT cord-331066-ediowz4s 37 12 membrane membrane NN cord-331066-ediowz4s 37 13 envelope envelope NN cord-331066-ediowz4s 37 14 like like IN cord-331066-ediowz4s 37 15 that that DT cord-331066-ediowz4s 37 16 for for IN cord-331066-ediowz4s 37 17 coronaviruses coronaviruse NNS cord-331066-ediowz4s 37 18 assumes assume VBZ cord-331066-ediowz4s 37 19 three three CD cord-331066-ediowz4s 37 20 stages stage NNS cord-331066-ediowz4s 37 21 related relate VBN cord-331066-ediowz4s 37 22 to to IN cord-331066-ediowz4s 37 23 the the DT cord-331066-ediowz4s 37 24 complete complete JJ cord-331066-ediowz4s 37 25 packaging packaging NN cord-331066-ediowz4s 37 26 of of IN cord-331066-ediowz4s 37 27 the the DT cord-331066-ediowz4s 37 28 genomic genomic JJ cord-331066-ediowz4s 37 29 RNA rna NN cord-331066-ediowz4s 37 30 within within IN cord-331066-ediowz4s 37 31 the the DT cord-331066-ediowz4s 37 32 envelope envelope NN cord-331066-ediowz4s 37 33 : : : cord-331066-ediowz4s 37 34 two two CD cord-331066-ediowz4s 37 35 - - HYPH cord-331066-ediowz4s 37 36 staged stage VBN cord-331066-ediowz4s 37 37 assembly assembly NN cord-331066-ediowz4s 37 38 / / SYM cord-331066-ediowz4s 37 39 packaging packaging NN cord-331066-ediowz4s 37 40 of of IN cord-331066-ediowz4s 37 41 the the DT cord-331066-ediowz4s 37 42 helical helical JJ cord-331066-ediowz4s 37 43 ribonucleocapsid ribonucleocapsid NN cord-331066-ediowz4s 37 44 and and CC cord-331066-ediowz4s 37 45 packaging packaging NN cord-331066-ediowz4s 37 46 of of IN cord-331066-ediowz4s 37 47 the the DT cord-331066-ediowz4s 37 48 ribonucleocapsid ribonucleocapsid NN cord-331066-ediowz4s 37 49 within within IN cord-331066-ediowz4s 37 50 the the DT cord-331066-ediowz4s 37 51 envelope envelope NN cord-331066-ediowz4s 37 52 . . . cord-331066-ediowz4s 38 1 This this DT cord-331066-ediowz4s 38 2 article article NN cord-331066-ediowz4s 38 3 is be VBZ cord-331066-ediowz4s 38 4 devoted devote VBN cord-331066-ediowz4s 38 5 to to TO cord-331066-ediowz4s 38 6 search search VB cord-331066-ediowz4s 38 7 for for IN cord-331066-ediowz4s 38 8 specific specific JJ cord-331066-ediowz4s 38 9 signals signal NNS cord-331066-ediowz4s 38 10 in in IN cord-331066-ediowz4s 38 11 the the DT cord-331066-ediowz4s 38 12 genomic genomic JJ cord-331066-ediowz4s 38 13 ssRNA ssrna NN cord-331066-ediowz4s 38 14 sequences sequence NNS cord-331066-ediowz4s 38 15 related relate VBN cord-331066-ediowz4s 38 16 to to IN cord-331066-ediowz4s 38 17 the the DT cord-331066-ediowz4s 38 18 two two CD cord-331066-ediowz4s 38 19 - - HYPH cord-331066-ediowz4s 38 20 staged stage VBN cord-331066-ediowz4s 38 21 assembly assembly NN cord-331066-ediowz4s 38 22 / / SYM cord-331066-ediowz4s 38 23 packaging packaging NN cord-331066-ediowz4s 38 24 of of IN cord-331066-ediowz4s 38 25 the the DT cord-331066-ediowz4s 38 26 helical helical JJ cord-331066-ediowz4s 38 27 ribonucleocapsid ribonucleocapsid NNP cord-331066-ediowz4s 38 28 . . . cord-331066-ediowz4s 39 1 As as IN cord-331066-ediowz4s 39 2 has have VBZ cord-331066-ediowz4s 39 3 been be VBN cord-331066-ediowz4s 39 4 shown show VBN cord-331066-ediowz4s 39 5 previously previously RB cord-331066-ediowz4s 39 6 , , , cord-331066-ediowz4s 39 7 the the DT cord-331066-ediowz4s 39 8 icosahedral icosahedral JJ cord-331066-ediowz4s 39 9 symmetry symmetry NN cord-331066-ediowz4s 39 10 of of IN cord-331066-ediowz4s 39 11 the the DT cord-331066-ediowz4s 39 12 capsid capsid NN cord-331066-ediowz4s 39 13 strongly strongly RB cord-331066-ediowz4s 39 14 affects affect VBZ cord-331066-ediowz4s 39 15 the the DT cord-331066-ediowz4s 39 16 large large JJ cord-331066-ediowz4s 39 17 - - HYPH cord-331066-ediowz4s 39 18 scale scale NN cord-331066-ediowz4s 39 19 quasi quasi JJ cord-331066-ediowz4s 39 20 - - JJ cord-331066-ediowz4s 39 21 periodic periodic JJ cord-331066-ediowz4s 39 22 segmentation segmentation NN cord-331066-ediowz4s 39 23 in in IN cord-331066-ediowz4s 39 24 the the DT cord-331066-ediowz4s 39 25 related relate VBN cord-331066-ediowz4s 39 26 viral viral JJ cord-331066-ediowz4s 39 27 genomes genome NNS cord-331066-ediowz4s 39 28 ( ( -LRB- cord-331066-ediowz4s 39 29 Chechetkin Chechetkin NNP cord-331066-ediowz4s 39 30 & & CC cord-331066-ediowz4s 39 31 Lobzin Lobzin NNP cord-331066-ediowz4s 39 32 , , , cord-331066-ediowz4s 39 33 2019 2019 CD cord-331066-ediowz4s 39 34 ) ) -RRB- cord-331066-ediowz4s 39 35 . . . cord-331066-ediowz4s 40 1 The the DT cord-331066-ediowz4s 40 2 whole whole JJ cord-331066-ediowz4s 40 3 ribonucleocapsid ribonucleocapsid NNP cord-331066-ediowz4s 40 4 structure structure NN cord-331066-ediowz4s 40 5 of of IN cord-331066-ediowz4s 40 6 coronaviruses coronaviruse NNS cord-331066-ediowz4s 40 7 also also RB cord-331066-ediowz4s 40 8 remains remain VBZ cord-331066-ediowz4s 40 9 invariant invariant JJ cord-331066-ediowz4s 40 10 under under IN cord-331066-ediowz4s 40 11 transition transition NN cord-331066-ediowz4s 40 12 by by IN cord-331066-ediowz4s 40 13 one one CD cord-331066-ediowz4s 40 14 helical helical JJ cord-331066-ediowz4s 40 15 turn turn NN cord-331066-ediowz4s 40 16 . . . cord-331066-ediowz4s 41 1 Therefore therefore RB cord-331066-ediowz4s 41 2 , , , cord-331066-ediowz4s 41 3 the the DT cord-331066-ediowz4s 41 4 putative putative JJ cord-331066-ediowz4s 41 5 weakly weakly RB cord-331066-ediowz4s 41 6 specific specific JJ cord-331066-ediowz4s 41 7 assembly assembly NN cord-331066-ediowz4s 41 8 / / SYM cord-331066-ediowz4s 41 9 packaging packaging NN cord-331066-ediowz4s 41 10 signals signal NNS cord-331066-ediowz4s 41 11 in in IN cord-331066-ediowz4s 41 12 the the DT cord-331066-ediowz4s 41 13 genomic genomic JJ cord-331066-ediowz4s 41 14 RNA RNA NNP cord-331066-ediowz4s 41 15 of of IN cord-331066-ediowz4s 41 16 coronaviruses coronaviruse NNS cord-331066-ediowz4s 41 17 should should MD cord-331066-ediowz4s 41 18 be be VB cord-331066-ediowz4s 41 19 coordinated coordinate VBN cord-331066-ediowz4s 41 20 with with IN cord-331066-ediowz4s 41 21 the the DT cord-331066-ediowz4s 41 22 parameters parameter NNS cord-331066-ediowz4s 41 23 of of IN cord-331066-ediowz4s 41 24 the the DT cord-331066-ediowz4s 41 25 helical helical JJ cord-331066-ediowz4s 41 26 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 41 27 ( ( -LRB- cord-331066-ediowz4s 41 28 such such JJ cord-331066-ediowz4s 41 29 as as IN cord-331066-ediowz4s 41 30 the the DT cord-331066-ediowz4s 41 31 helix helix NN cord-331066-ediowz4s 41 32 pitch pitch NN cord-331066-ediowz4s 41 33 , , , cord-331066-ediowz4s 41 34 inner inner JJ cord-331066-ediowz4s 41 35 and and CC cord-331066-ediowz4s 41 36 outer outer JJ cord-331066-ediowz4s 41 37 diameters diameter NNS cord-331066-ediowz4s 41 38 ) ) -RRB- cord-331066-ediowz4s 41 39 which which WDT cord-331066-ediowz4s 41 40 are be VBP cord-331066-ediowz4s 41 41 established establish VBN cord-331066-ediowz4s 41 42 by by IN cord-331066-ediowz4s 41 43 cryoelectron cryoelectron NNP cord-331066-ediowz4s 41 44 microscopy microscopy NNP cord-331066-ediowz4s 41 45 ( ( -LRB- cord-331066-ediowz4s 41 46 cryo cryo NN cord-331066-ediowz4s 41 47 - - HYPH cord-331066-ediowz4s 41 48 EM EM NNP cord-331066-ediowz4s 41 49 ) ) -RRB- cord-331066-ediowz4s 41 50 and and CC cord-331066-ediowz4s 41 51 other other JJ cord-331066-ediowz4s 41 52 structural structural JJ cord-331066-ediowz4s 41 53 methods method NNS cord-331066-ediowz4s 41 54 . . . cord-331066-ediowz4s 42 1 In in IN cord-331066-ediowz4s 42 2 this this DT cord-331066-ediowz4s 42 3 article article NN cord-331066-ediowz4s 42 4 , , , cord-331066-ediowz4s 42 5 we -PRON- PRP cord-331066-ediowz4s 42 6 provide provide VBP cord-331066-ediowz4s 42 7 methods method NNS cord-331066-ediowz4s 42 8 for for IN cord-331066-ediowz4s 42 9 the the DT cord-331066-ediowz4s 42 10 detection detection NN cord-331066-ediowz4s 42 11 and and CC cord-331066-ediowz4s 42 12 comparative comparative JJ cord-331066-ediowz4s 42 13 analysis analysis NN cord-331066-ediowz4s 42 14 of of IN cord-331066-ediowz4s 42 15 assembly assembly NN cord-331066-ediowz4s 42 16 / / SYM cord-331066-ediowz4s 42 17 packaging packaging NN cord-331066-ediowz4s 42 18 signals signal NNS cord-331066-ediowz4s 42 19 in in IN cord-331066-ediowz4s 42 20 the the DT cord-331066-ediowz4s 42 21 genomic genomic JJ cord-331066-ediowz4s 42 22 RNA RNA NNP cord-331066-ediowz4s 42 23 of of IN cord-331066-ediowz4s 42 24 the the DT cord-331066-ediowz4s 42 25 coronaviruses coronaviruses NNP cord-331066-ediowz4s 42 26 SARS SARS NNP cord-331066-ediowz4s 42 27 - - HYPH cord-331066-ediowz4s 42 28 CoV CoV NNP cord-331066-ediowz4s 42 29 and and CC cord-331066-ediowz4s 42 30 SARS SARS NNP cord-331066-ediowz4s 42 31 - - HYPH cord-331066-ediowz4s 42 32 CoV-2 CoV-2 NNP cord-331066-ediowz4s 42 33 and and CC cord-331066-ediowz4s 42 34 describe describe VB cord-331066-ediowz4s 42 35 main main JJ cord-331066-ediowz4s 42 36 results result NNS cord-331066-ediowz4s 42 37 of of IN cord-331066-ediowz4s 42 38 our -PRON- PRP$ cord-331066-ediowz4s 42 39 study study NN cord-331066-ediowz4s 42 40 . . . cord-331066-ediowz4s 43 1 The the DT cord-331066-ediowz4s 43 2 quasi quasi JJ cord-331066-ediowz4s 43 3 - - JJ cord-331066-ediowz4s 43 4 periodic periodic JJ cord-331066-ediowz4s 43 5 patterns pattern NNS cord-331066-ediowz4s 43 6 in in IN cord-331066-ediowz4s 43 7 the the DT cord-331066-ediowz4s 43 8 genomic genomic JJ cord-331066-ediowz4s 43 9 DNA DNA NNP cord-331066-ediowz4s 43 10 / / SYM cord-331066-ediowz4s 43 11 RNA RNA NNP cord-331066-ediowz4s 43 12 sequences sequence NNS cord-331066-ediowz4s 43 13 can can MD cord-331066-ediowz4s 43 14 be be VB cord-331066-ediowz4s 43 15 efficiently efficiently RB cord-331066-ediowz4s 43 16 detected detect VBN cord-331066-ediowz4s 43 17 with with IN cord-331066-ediowz4s 43 18 the the DT cord-331066-ediowz4s 43 19 discrete discrete JJ cord-331066-ediowz4s 43 20 Fourier Fourier NNP cord-331066-ediowz4s 43 21 transform transform NN cord-331066-ediowz4s 43 22 ( ( -LRB- cord-331066-ediowz4s 43 23 DFT DFT NNP cord-331066-ediowz4s 43 24 ) ) -RRB- cord-331066-ediowz4s 43 25 . . . cord-331066-ediowz4s 44 1 As as IN cord-331066-ediowz4s 44 2 the the DT cord-331066-ediowz4s 44 3 periodic periodic JJ cord-331066-ediowz4s 44 4 patterns pattern NNS cord-331066-ediowz4s 44 5 generate generate VBP cord-331066-ediowz4s 44 6 equidistant equidistant JJ cord-331066-ediowz4s 44 7 series series NN cord-331066-ediowz4s 44 8 of of IN cord-331066-ediowz4s 44 9 harmonics harmonic NNS cord-331066-ediowz4s 44 10 in in IN cord-331066-ediowz4s 44 11 the the DT cord-331066-ediowz4s 44 12 DFT DFT NNP cord-331066-ediowz4s 44 13 spectra spectrum NNS cord-331066-ediowz4s 44 14 ( ( -LRB- cord-331066-ediowz4s 44 15 see see VB cord-331066-ediowz4s 44 16 , , , cord-331066-ediowz4s 44 17 e.g. e.g. RB cord-331066-ediowz4s 44 18 Chechetkin Chechetkin NNP cord-331066-ediowz4s 44 19 & & CC cord-331066-ediowz4s 44 20 Turygin Turygin NNP cord-331066-ediowz4s 44 21 , , , cord-331066-ediowz4s 44 22 1995 1995 CD cord-331066-ediowz4s 44 23 ; ; : cord-331066-ediowz4s 44 24 Lobzin Lobzin NNP cord-331066-ediowz4s 44 25 & & CC cord-331066-ediowz4s 44 26 Chechetkin Chechetkin NNP cord-331066-ediowz4s 44 27 , , , cord-331066-ediowz4s 44 28 2000 2000 CD cord-331066-ediowz4s 44 29 ) ) -RRB- cord-331066-ediowz4s 44 30 , , , cord-331066-ediowz4s 44 31 long long JJ cord-331066-ediowz4s 44 32 enough enough JJ cord-331066-ediowz4s 44 33 patterns pattern NNS cord-331066-ediowz4s 44 34 can can MD cord-331066-ediowz4s 44 35 be be VB cord-331066-ediowz4s 44 36 detected detect VBN cord-331066-ediowz4s 44 37 by by IN cord-331066-ediowz4s 44 38 the the DT cord-331066-ediowz4s 44 39 iteration iteration NN cord-331066-ediowz4s 44 40 of of IN cord-331066-ediowz4s 44 41 DFT DFT NNP cord-331066-ediowz4s 44 42 or or CC cord-331066-ediowz4s 44 43 by by IN cord-331066-ediowz4s 44 44 the the DT cord-331066-ediowz4s 44 45 discrete discrete JJ cord-331066-ediowz4s 44 46 double double JJ cord-331066-ediowz4s 44 47 Fourier Fourier NNP cord-331066-ediowz4s 44 48 transform transform NN cord-331066-ediowz4s 44 49 ( ( -LRB- cord-331066-ediowz4s 44 50 DDFT DDFT NNP cord-331066-ediowz4s 44 51 ) ) -RRB- cord-331066-ediowz4s 45 1 ( ( -LRB- cord-331066-ediowz4s 45 2 Chechetkin Chechetkin NNP cord-331066-ediowz4s 45 3 & & CC cord-331066-ediowz4s 45 4 Lobzin Lobzin NNP cord-331066-ediowz4s 45 5 , , , cord-331066-ediowz4s 45 6 2017 2017 CD cord-331066-ediowz4s 45 7 , , , cord-331066-ediowz4s 45 8 2019 2019 CD cord-331066-ediowz4s 45 9 , , , cord-331066-ediowz4s 45 10 2020a 2020a NNS cord-331066-ediowz4s 45 11 , , , cord-331066-ediowz4s 45 12 2020b 2020b NNS cord-331066-ediowz4s 45 13 . . . cord-331066-ediowz4s 46 1 Although although IN cord-331066-ediowz4s 46 2 , , , cord-331066-ediowz4s 46 3 the the DT cord-331066-ediowz4s 46 4 correlation correlation NN cord-331066-ediowz4s 46 5 functions function NNS cord-331066-ediowz4s 46 6 are be VBP cord-331066-ediowz4s 46 7 the the DT cord-331066-ediowz4s 46 8 main main JJ cord-331066-ediowz4s 46 9 tools tool NNS cord-331066-ediowz4s 46 10 in in IN cord-331066-ediowz4s 46 11 this this DT cord-331066-ediowz4s 46 12 article article NN cord-331066-ediowz4s 46 13 , , , cord-331066-ediowz4s 46 14 our -PRON- PRP$ cord-331066-ediowz4s 46 15 approach approach NN cord-331066-ediowz4s 46 16 is be VBZ cord-331066-ediowz4s 46 17 based base VBN cord-331066-ediowz4s 46 18 implicitly implicitly RB cord-331066-ediowz4s 46 19 and and CC cord-331066-ediowz4s 46 20 explicitly explicitly RB cord-331066-ediowz4s 46 21 on on IN cord-331066-ediowz4s 46 22 DFT DFT NNP cord-331066-ediowz4s 46 23 and and CC cord-331066-ediowz4s 46 24 DDFT DDFT NNP cord-331066-ediowz4s 46 25 . . . cord-331066-ediowz4s 47 1 Therefore therefore RB cord-331066-ediowz4s 47 2 , , , cord-331066-ediowz4s 47 3 we -PRON- PRP cord-331066-ediowz4s 47 4 begin begin VBP cord-331066-ediowz4s 47 5 with with IN cord-331066-ediowz4s 47 6 the the DT cord-331066-ediowz4s 47 7 definitions definition NNS cord-331066-ediowz4s 47 8 of of IN cord-331066-ediowz4s 47 9 these these DT cord-331066-ediowz4s 47 10 operations operation NNS cord-331066-ediowz4s 47 11 . . . cord-331066-ediowz4s 48 1 Below below RB cord-331066-ediowz4s 48 2 , , , cord-331066-ediowz4s 48 3 we -PRON- PRP cord-331066-ediowz4s 48 4 follow follow VBP cord-331066-ediowz4s 48 5 the the DT cord-331066-ediowz4s 48 6 methods method NNS cord-331066-ediowz4s 48 7 developed develop VBN cord-331066-ediowz4s 48 8 previously previously RB cord-331066-ediowz4s 48 9 ( ( -LRB- cord-331066-ediowz4s 48 10 Chechetkin Chechetkin NNP cord-331066-ediowz4s 48 11 & & CC cord-331066-ediowz4s 48 12 Lobzin Lobzin NNP cord-331066-ediowz4s 48 13 , , , cord-331066-ediowz4s 48 14 2017 2017 CD cord-331066-ediowz4s 48 15 , , , cord-331066-ediowz4s 48 16 2020a 2020a NNS cord-331066-ediowz4s 48 17 , , , cord-331066-ediowz4s 48 18 2020b 2020b CD cord-331066-ediowz4s 48 19 Chechetkin Chechetkin NNP cord-331066-ediowz4s 48 20 & & CC cord-331066-ediowz4s 48 21 Turygin Turygin NNP cord-331066-ediowz4s 48 22 , , , cord-331066-ediowz4s 48 23 1994 1994 CD cord-331066-ediowz4s 48 24 , , , cord-331066-ediowz4s 48 25 1995 1995 CD cord-331066-ediowz4s 48 26 Lobzin Lobzin NNP cord-331066-ediowz4s 48 27 & & CC cord-331066-ediowz4s 48 28 Chechetkin Chechetkin NNP cord-331066-ediowz4s 48 29 , , , cord-331066-ediowz4s 48 30 2000 2000 CD cord-331066-ediowz4s 48 31 ) ) -RRB- cord-331066-ediowz4s 48 32 . . . cord-331066-ediowz4s 49 1 The the DT cord-331066-ediowz4s 49 2 DFT DFT NNP cord-331066-ediowz4s 49 3 harmonics harmonic NNS cord-331066-ediowz4s 49 4 corresponding correspond VBG cord-331066-ediowz4s 49 5 to to IN cord-331066-ediowz4s 49 6 the the DT cord-331066-ediowz4s 49 7 nucleotides nucleotide NNS cord-331066-ediowz4s 49 8 of of IN cord-331066-ediowz4s 49 9 type type NN cord-331066-ediowz4s 49 10 a a DT cord-331066-ediowz4s 49 11 2(A 2(a NN cord-331066-ediowz4s 49 12 , , , cord-331066-ediowz4s 49 13 C C NNP cord-331066-ediowz4s 49 14 , , , cord-331066-ediowz4s 49 15 G G NNP cord-331066-ediowz4s 49 16 , , , cord-331066-ediowz4s 49 17 T T NNP cord-331066-ediowz4s 49 18 ) ) -RRB- cord-331066-ediowz4s 49 19 in in IN cord-331066-ediowz4s 49 20 a a DT cord-331066-ediowz4s 49 21 genomic genomic JJ cord-331066-ediowz4s 49 22 sequence sequence NN cord-331066-ediowz4s 49 23 of of IN cord-331066-ediowz4s 49 24 length length NN cord-331066-ediowz4s 49 25 M M NNP cord-331066-ediowz4s 49 26 are be VBP cord-331066-ediowz4s 49 27 calculated calculate VBN cord-331066-ediowz4s 49 28 as as IN cord-331066-ediowz4s 49 29 q q NNP cord-331066-ediowz4s 49 30 m m NNP cord-331066-ediowz4s 49 31 , , , cord-331066-ediowz4s 49 32 a a DT cord-331066-ediowz4s 49 33 e e NNP cord-331066-ediowz4s 49 34 Àiqnm Àiqnm NNP cord-331066-ediowz4s 49 35 , , , cord-331066-ediowz4s 49 36 q q NNP cord-331066-ediowz4s 49 37 n n NNP cord-331066-ediowz4s 49 38 ¼ ¼ NNP cord-331066-ediowz4s 49 39 2pn= 2pn= NNP cord-331066-ediowz4s 50 1 M M NNP cord-331066-ediowz4s 50 2 , , , cord-331066-ediowz4s 50 3 n n NN cord-331066-ediowz4s 50 4 ¼ ¼ NNP cord-331066-ediowz4s 50 5 0 0 CD cord-331066-ediowz4s 50 6 , , , cord-331066-ediowz4s 50 7 1 1 CD cord-331066-ediowz4s 50 8 , , , cord-331066-ediowz4s 50 9 : : : cord-331066-ediowz4s 50 10 : : : cord-331066-ediowz4s 50 11 : : : cord-331066-ediowz4s 50 12 , , , cord-331066-ediowz4s 50 13 MÀ1 MÀ1 NNP cord-331066-ediowz4s 50 14 : : : cord-331066-ediowz4s 51 1 Here here RB cord-331066-ediowz4s 51 2 , , , cord-331066-ediowz4s 51 3 q q NNP cord-331066-ediowz4s 51 4 m m NNP cord-331066-ediowz4s 51 5 , , , cord-331066-ediowz4s 51 6 a a DT cord-331066-ediowz4s 51 7 indicates indicate VBZ cord-331066-ediowz4s 51 8 the the DT cord-331066-ediowz4s 51 9 position position NN cord-331066-ediowz4s 51 10 occupied occupy VBN cord-331066-ediowz4s 51 11 by by IN cord-331066-ediowz4s 51 12 the the DT cord-331066-ediowz4s 51 13 nucleotide nucleotide NN cord-331066-ediowz4s 51 14 of of IN cord-331066-ediowz4s 51 15 type type NN cord-331066-ediowz4s 51 16 a a NN cord-331066-ediowz4s 51 17 ; ; : cord-331066-ediowz4s 51 18 q q NNP cord-331066-ediowz4s 51 19 m m NNP cord-331066-ediowz4s 51 20 , , , cord-331066-ediowz4s 51 21 a a DT cord-331066-ediowz4s 51 22 ¼ ¼ CD cord-331066-ediowz4s 51 23 1 1 CD cord-331066-ediowz4s 51 24 if if IN cord-331066-ediowz4s 51 25 the the DT cord-331066-ediowz4s 51 26 nucleotide nucleotide NN cord-331066-ediowz4s 51 27 of of IN cord-331066-ediowz4s 51 28 type type NN cord-331066-ediowz4s 51 29 a a NN cord-331066-ediowz4s 51 30 occupies occupy VBZ cord-331066-ediowz4s 51 31 the the DT cord-331066-ediowz4s 51 32 mth mth NN cord-331066-ediowz4s 51 33 site site NN cord-331066-ediowz4s 51 34 and and CC cord-331066-ediowz4s 51 35 0 0 NFP cord-331066-ediowz4s 51 36 otherwise otherwise RB cord-331066-ediowz4s 51 37 . . . cord-331066-ediowz4s 52 1 The the DT cord-331066-ediowz4s 52 2 amplitudes amplitude NNS cord-331066-ediowz4s 52 3 of of IN cord-331066-ediowz4s 52 4 Fourier Fourier NNP cord-331066-ediowz4s 52 5 harmonics harmonic NNS cord-331066-ediowz4s 52 6 ( ( -LRB- cord-331066-ediowz4s 52 7 or or CC cord-331066-ediowz4s 52 8 structure structure NN cord-331066-ediowz4s 52 9 factors factor NNS cord-331066-ediowz4s 52 10 ) ) -RRB- cord-331066-ediowz4s 52 11 are be VBP cord-331066-ediowz4s 52 12 defined define VBN cord-331066-ediowz4s 52 13 as as IN cord-331066-ediowz4s 52 14 where where WRB cord-331066-ediowz4s 52 15 the the DT cord-331066-ediowz4s 52 16 asterisk asterisk NN cord-331066-ediowz4s 52 17 denotes denote VBZ cord-331066-ediowz4s 52 18 the the DT cord-331066-ediowz4s 52 19 complex complex JJ cord-331066-ediowz4s 52 20 conjugation conjugation NN cord-331066-ediowz4s 52 21 . . . cord-331066-ediowz4s 53 1 Taking take VBG cord-331066-ediowz4s 53 2 into into IN cord-331066-ediowz4s 53 3 account account NN cord-331066-ediowz4s 53 4 the the DT cord-331066-ediowz4s 53 5 symmetry symmetry NN cord-331066-ediowz4s 53 6 relationship relationship NN cord-331066-ediowz4s 53 7 for for IN cord-331066-ediowz4s 53 8 the the DT cord-331066-ediowz4s 53 9 structure structure NN cord-331066-ediowz4s 53 10 factors factor NNS cord-331066-ediowz4s 53 11 , , , cord-331066-ediowz4s 53 12 the the DT cord-331066-ediowz4s 53 13 analysis analysis NN cord-331066-ediowz4s 53 14 of of IN cord-331066-ediowz4s 53 15 their -PRON- PRP$ cord-331066-ediowz4s 53 16 spectra spectrum NNS cord-331066-ediowz4s 53 17 can can MD cord-331066-ediowz4s 53 18 be be VB cord-331066-ediowz4s 53 19 restricted restrict VBN cord-331066-ediowz4s 53 20 by by IN cord-331066-ediowz4s 53 21 the the DT cord-331066-ediowz4s 53 22 range range NN cord-331066-ediowz4s 53 23 from from IN cord-331066-ediowz4s 53 24 n n NNP cord-331066-ediowz4s 53 25 ¼ ¼ NNP cord-331066-ediowz4s 53 26 1 1 CD cord-331066-ediowz4s 53 27 to to IN cord-331066-ediowz4s 53 28 where where WRB cord-331066-ediowz4s 53 29 the the DT cord-331066-ediowz4s 53 30 brackets bracket NNS cord-331066-ediowz4s 53 31 denote denote VBP cord-331066-ediowz4s 53 32 the the DT cord-331066-ediowz4s 53 33 integer integer JJ cord-331066-ediowz4s 53 34 part part NN cord-331066-ediowz4s 53 35 of of IN cord-331066-ediowz4s 53 36 the the DT cord-331066-ediowz4s 53 37 quotient quotient NN cord-331066-ediowz4s 53 38 . . . cord-331066-ediowz4s 54 1 The the DT cord-331066-ediowz4s 54 2 structure structure NN cord-331066-ediowz4s 54 3 factors factor NNS cord-331066-ediowz4s 54 4 will will MD cord-331066-ediowz4s 54 5 always always RB cord-331066-ediowz4s 54 6 be be VB cord-331066-ediowz4s 54 7 normalized normalize VBN cord-331066-ediowz4s 54 8 on on IN cord-331066-ediowz4s 54 9 the the DT cord-331066-ediowz4s 54 10 mean mean JJ cord-331066-ediowz4s 54 11 spectral spectral JJ cord-331066-ediowz4s 54 12 values value NNS cord-331066-ediowz4s 54 13 , , , cord-331066-ediowz4s 54 14 which which WDT cord-331066-ediowz4s 54 15 are be VBP cord-331066-ediowz4s 54 16 determined determine VBN cord-331066-ediowz4s 54 17 by by IN cord-331066-ediowz4s 54 18 the the DT cord-331066-ediowz4s 54 19 exact exact JJ cord-331066-ediowz4s 54 20 sum sum NN cord-331066-ediowz4s 54 21 rules rule NNS cord-331066-ediowz4s 54 22 , , , cord-331066-ediowz4s 54 23 where where WRB cord-331066-ediowz4s 54 24 N N NNP cord-331066-ediowz4s 54 25 a a DT cord-331066-ediowz4s 54 26 is be VBZ cord-331066-ediowz4s 54 27 the the DT cord-331066-ediowz4s 54 28 total total JJ cord-331066-ediowz4s 54 29 number number NN cord-331066-ediowz4s 54 30 of of IN cord-331066-ediowz4s 54 31 the the DT cord-331066-ediowz4s 54 32 nucleotides nucleotide NNS cord-331066-ediowz4s 54 33 of of IN cord-331066-ediowz4s 54 34 type type NN cord-331066-ediowz4s 54 35 a a DT cord-331066-ediowz4s 54 36 in in IN cord-331066-ediowz4s 54 37 a a DT cord-331066-ediowz4s 54 38 sequence sequence NN cord-331066-ediowz4s 54 39 of of IN cord-331066-ediowz4s 54 40 length length NN cord-331066-ediowz4s 55 1 M. M. NNP cord-331066-ediowz4s 55 2 Below below RB cord-331066-ediowz4s 55 3 , , , cord-331066-ediowz4s 55 4 we -PRON- PRP cord-331066-ediowz4s 55 5 will will MD cord-331066-ediowz4s 55 6 also also RB cord-331066-ediowz4s 55 7 use use VB cord-331066-ediowz4s 55 8 the the DT cord-331066-ediowz4s 55 9 sums sum NNS cord-331066-ediowz4s 55 10 , , , cord-331066-ediowz4s 55 11 which which WDT cord-331066-ediowz4s 55 12 can can MD cord-331066-ediowz4s 55 13 be be VB cord-331066-ediowz4s 55 14 applied apply VBN cord-331066-ediowz4s 55 15 to to IN cord-331066-ediowz4s 55 16 the the DT cord-331066-ediowz4s 55 17 detection detection NN cord-331066-ediowz4s 55 18 of of IN cord-331066-ediowz4s 55 19 quasi quasi JJ cord-331066-ediowz4s 55 20 - - JJ cord-331066-ediowz4s 55 21 periodic periodic JJ cord-331066-ediowz4s 55 22 patterns pattern NNS cord-331066-ediowz4s 55 23 or or CC cord-331066-ediowz4s 55 24 motifs motif NNS cord-331066-ediowz4s 55 25 composed compose VBN cord-331066-ediowz4s 55 26 of of IN cord-331066-ediowz4s 55 27 the the DT cord-331066-ediowz4s 55 28 nucleotides nucleotide NNS cord-331066-ediowz4s 55 29 of of IN cord-331066-ediowz4s 55 30 different different JJ cord-331066-ediowz4s 55 31 types type NNS cord-331066-ediowz4s 55 32 . . . cord-331066-ediowz4s 56 1 The the DT cord-331066-ediowz4s 56 2 period period NN cord-331066-ediowz4s 56 3 p p NN cord-331066-ediowz4s 56 4 is be VBZ cord-331066-ediowz4s 56 5 measured measure VBN cord-331066-ediowz4s 56 6 in in IN cord-331066-ediowz4s 56 7 terms term NNS cord-331066-ediowz4s 56 8 of of IN cord-331066-ediowz4s 56 9 the the DT cord-331066-ediowz4s 56 10 number number NN cord-331066-ediowz4s 56 11 of of IN cord-331066-ediowz4s 56 12 nucleotides nucleotide NNS cord-331066-ediowz4s 56 13 ( ( -LRB- cord-331066-ediowz4s 56 14 these these DT cord-331066-ediowz4s 56 15 units unit NNS cord-331066-ediowz4s 56 16 will will MD cord-331066-ediowz4s 56 17 always always RB cord-331066-ediowz4s 56 18 be be VB cord-331066-ediowz4s 56 19 tacitly tacitly RB cord-331066-ediowz4s 56 20 implied imply VBN cord-331066-ediowz4s 56 21 below below IN cord-331066-ediowz4s 56 22 ) ) -RRB- cord-331066-ediowz4s 56 23 and and CC cord-331066-ediowz4s 56 24 is be VBZ cord-331066-ediowz4s 56 25 calculated calculate VBN cord-331066-ediowz4s 56 26 as as IN cord-331066-ediowz4s 56 27 , , , cord-331066-ediowz4s 56 28 The the DT cord-331066-ediowz4s 56 29 harmonics harmonic NNS cord-331066-ediowz4s 56 30 in in IN cord-331066-ediowz4s 56 31 DDFT DDFT NNP cord-331066-ediowz4s 56 32 are be VBP cord-331066-ediowz4s 56 33 calculated calculate VBN cord-331066-ediowz4s 56 34 as as IN cord-331066-ediowz4s 56 35 U U NNP cord-331066-ediowz4s 56 36 a a DT cord-331066-ediowz4s 56 37 ðq ðq NN cord-331066-ediowz4s 56 38 n n NN cord-331066-ediowz4s 56 39 0 0 CD cord-331066-ediowz4s 57 1 Þ Þ NNP cord-331066-ediowz4s 57 2 ¼ ¼ CD cord-331066-ediowz4s 57 3 ðNÀ1Þ ðnà1þ CD cord-331066-ediowz4s 57 4 À1=2 À1=2 NNP cord-331066-ediowz4s 57 5 X X NNP cord-331066-ediowz4s 57 6 N N NNP cord-331066-ediowz4s 57 7 n¼2 n¼2 NN cord-331066-ediowz4s 57 8 f f NNP cord-331066-ediowz4s 58 1 aa aa NNP cord-331066-ediowz4s 58 2 ðq ðq NNP cord-331066-ediowz4s 59 1 n n CC cord-331066-ediowz4s 59 2 Þe Þe NNP cord-331066-ediowz4s 59 3 Àiq Àiq NNP cord-331066-ediowz4s 59 4 n n NN cord-331066-ediowz4s 59 5 0 0 CD cord-331066-ediowz4s 59 6 n n NN cord-331066-ediowz4s 59 7 , , , cord-331066-ediowz4s 59 8 q q NNP cord-331066-ediowz4s 59 9 n n NN cord-331066-ediowz4s 59 10 0 0 CD cord-331066-ediowz4s 59 11 ¼ ¼ CD cord-331066-ediowz4s 59 12 2pn 2pn JJ cord-331066-ediowz4s 59 13 0 0 CD cord-331066-ediowz4s 59 14 = = SYM cord-331066-ediowz4s 59 15 ðNÀ1Þ ðnà1þ CD cord-331066-ediowz4s 59 16 , , , cord-331066-ediowz4s 59 17 n n NN cord-331066-ediowz4s 59 18 0 0 CD cord-331066-ediowz4s 59 19 ¼ ¼ CD cord-331066-ediowz4s 59 20 0 0 CD cord-331066-ediowz4s 59 21 , , , cord-331066-ediowz4s 59 22 1 1 CD cord-331066-ediowz4s 59 23 , , , cord-331066-ediowz4s 59 24 : : : cord-331066-ediowz4s 59 25 : : : cord-331066-ediowz4s 59 26 : : : cord-331066-ediowz4s 59 27 , , , cord-331066-ediowz4s 59 28 NÀ2 NÀ2 NNP cord-331066-ediowz4s 59 29 , , , cord-331066-ediowz4s 59 30 where where WRB cord-331066-ediowz4s 59 31 N N NNP cord-331066-ediowz4s 59 32 is be VBZ cord-331066-ediowz4s 59 33 defined define VBN cord-331066-ediowz4s 59 34 by by IN cord-331066-ediowz4s 59 35 Equation equation NN cord-331066-ediowz4s 59 36 ( ( -LRB- cord-331066-ediowz4s 59 37 3 3 CD cord-331066-ediowz4s 59 38 ) ) -RRB- cord-331066-ediowz4s 59 39 and and CC cord-331066-ediowz4s 59 40 f f NNP cord-331066-ediowz4s 59 41 aa aa NNP cord-331066-ediowz4s 59 42 ðq ðq NN cord-331066-ediowz4s 59 43 n n CC cord-331066-ediowz4s 59 44 Þ Þ NNP cord-331066-ediowz4s 59 45 are be VBP cord-331066-ediowz4s 59 46 the the DT cord-331066-ediowz4s 59 47 normalized normalized JJ cord-331066-ediowz4s 59 48 structure structure NN cord-331066-ediowz4s 59 49 factors factor NNS cord-331066-ediowz4s 59 50 ( ( -LRB- cord-331066-ediowz4s 59 51 see see VB cord-331066-ediowz4s 59 52 Equation equation NN cord-331066-ediowz4s 59 53 ( ( -LRB- cord-331066-ediowz4s 59 54 4 4 CD cord-331066-ediowz4s 59 55 ) ) -RRB- cord-331066-ediowz4s 59 56 ) ) -RRB- cord-331066-ediowz4s 59 57 . . . cord-331066-ediowz4s 60 1 The the DT cord-331066-ediowz4s 60 2 similar similar JJ cord-331066-ediowz4s 60 3 transform transform NN cord-331066-ediowz4s 60 4 can can MD cord-331066-ediowz4s 60 5 be be VB cord-331066-ediowz4s 60 6 used use VBN cord-331066-ediowz4s 60 7 for for IN cord-331066-ediowz4s 60 8 the the DT cord-331066-ediowz4s 60 9 sums sum NNS cord-331066-ediowz4s 60 10 defined define VBN cord-331066-ediowz4s 60 11 by by IN cord-331066-ediowz4s 60 12 Equations equation NNS cord-331066-ediowz4s 60 13 ( ( -LRB- cord-331066-ediowz4s 60 14 5)-(7 5)-(7 CD cord-331066-ediowz4s 60 15 ) ) -RRB- cord-331066-ediowz4s 60 16 . . . cord-331066-ediowz4s 61 1 The the DT cord-331066-ediowz4s 61 2 amplitudes amplitude NNS cord-331066-ediowz4s 61 3 of of IN cord-331066-ediowz4s 61 4 harmonics harmonic NNS cord-331066-ediowz4s 61 5 are be VBP cord-331066-ediowz4s 61 6 given give VBN cord-331066-ediowz4s 61 7 by by IN cord-331066-ediowz4s 61 8 Similarly similarly RB cord-331066-ediowz4s 61 9 to to IN cord-331066-ediowz4s 61 10 DFT DFT NNP cord-331066-ediowz4s 61 11 , , , cord-331066-ediowz4s 61 12 the the DT cord-331066-ediowz4s 61 13 analysis analysis NN cord-331066-ediowz4s 61 14 of of IN cord-331066-ediowz4s 61 15 the the DT cord-331066-ediowz4s 61 16 spectra spectra NN cord-331066-ediowz4s 61 17 for for IN cord-331066-ediowz4s 61 18 the the DT cord-331066-ediowz4s 61 19 amplitudes amplitude NNS cord-331066-ediowz4s 61 20 defined define VBN cord-331066-ediowz4s 61 21 by by IN cord-331066-ediowz4s 61 22 Equation equation NN cord-331066-ediowz4s 61 23 ( ( -LRB- cord-331066-ediowz4s 61 24 10 10 CD cord-331066-ediowz4s 61 25 ) ) -RRB- cord-331066-ediowz4s 61 26 can can MD cord-331066-ediowz4s 61 27 be be VB cord-331066-ediowz4s 61 28 restricted restrict VBN cord-331066-ediowz4s 61 29 from from IN cord-331066-ediowz4s 61 30 n n NNP cord-331066-ediowz4s 61 31 ' ' POS cord-331066-ediowz4s 61 32 ¼ ¼ NNP cord-331066-ediowz4s 61 33 1 1 CD cord-331066-ediowz4s 61 34 to to IN cord-331066-ediowz4s 61 35 The the DT cord-331066-ediowz4s 61 36 DDFT DDFT NNP cord-331066-ediowz4s 61 37 amplitudes amplitude NNS cord-331066-ediowz4s 61 38 are be VBP cord-331066-ediowz4s 61 39 normalized normalize VBN cord-331066-ediowz4s 61 40 as as IN cord-331066-ediowz4s 61 41 Generally generally RB cord-331066-ediowz4s 61 42 , , , cord-331066-ediowz4s 61 43 equidistant equidistant JJ cord-331066-ediowz4s 61 44 series series NN cord-331066-ediowz4s 61 45 in in IN cord-331066-ediowz4s 61 46 DFT DFT NNP cord-331066-ediowz4s 61 47 spectra spectrum NNS cord-331066-ediowz4s 61 48 also also RB cord-331066-ediowz4s 61 49 generate generate VBP cord-331066-ediowz4s 61 50 the the DT cord-331066-ediowz4s 61 51 corresponding corresponding JJ cord-331066-ediowz4s 61 52 equidistant equidistant JJ cord-331066-ediowz4s 61 53 series series NN cord-331066-ediowz4s 61 54 in in IN cord-331066-ediowz4s 61 55 DDFT DDFT NNP cord-331066-ediowz4s 61 56 spectra spectra NNP cord-331066-ediowz4s 61 57 with with IN cord-331066-ediowz4s 61 58 the the DT cord-331066-ediowz4s 61 59 spectral spectral JJ cord-331066-ediowz4s 61 60 numbers number NNS cord-331066-ediowz4s 61 61 k k XX cord-331066-ediowz4s 61 62 0 0 CD cord-331066-ediowz4s 61 63 n n NN cord-331066-ediowz4s 61 64 0 0 CD cord-331066-ediowz4s 61 65 , , , cord-331066-ediowz4s 61 66 k k NNP cord-331066-ediowz4s 61 67 0 0 CD cord-331066-ediowz4s 61 68 ¼ ¼ NNP cord-331066-ediowz4s 61 69 1 1 CD cord-331066-ediowz4s 61 70 , , , cord-331066-ediowz4s 61 71 : : : cord-331066-ediowz4s 61 72 : : : cord-331066-ediowz4s 61 73 : : : cord-331066-ediowz4s 61 74 , , , cord-331066-ediowz4s 61 75 k k NNP cord-331066-ediowz4s 61 76 0 0 CD cord-331066-ediowz4s 61 77 max max NN cord-331066-ediowz4s 61 78 ; ; : cord-331066-ediowz4s 61 79 k k NNP cord-331066-ediowz4s 61 80 0 0 CD cord-331066-ediowz4s 61 81 max max NNP cord-331066-ediowz4s 61 82 n n NN cord-331066-ediowz4s 61 83 0 0 CD cord-331066-ediowz4s 61 84 N n CD cord-331066-ediowz4s 61 85 0 0 CD cord-331066-ediowz4s 61 86 , , , cord-331066-ediowz4s 61 87 where where WRB cord-331066-ediowz4s 61 88 N N NNP cord-331066-ediowz4s 61 89 ' ' '' cord-331066-ediowz4s 61 90 is be VBZ cord-331066-ediowz4s 61 91 defined define VBN cord-331066-ediowz4s 61 92 by by IN cord-331066-ediowz4s 61 93 Equation equation NN cord-331066-ediowz4s 61 94 ( ( -LRB- cord-331066-ediowz4s 61 95 11 11 CD cord-331066-ediowz4s 61 96 ) ) -RRB- cord-331066-ediowz4s 61 97 . . . cord-331066-ediowz4s 62 1 The the DT cord-331066-ediowz4s 62 2 number number NN cord-331066-ediowz4s 62 3 of of IN cord-331066-ediowz4s 62 4 quasi quasi JJ cord-331066-ediowz4s 62 5 - - JJ cord-331066-ediowz4s 62 6 periodic periodic JJ cord-331066-ediowz4s 62 7 patterns pattern NNS cord-331066-ediowz4s 62 8 can can MD cord-331066-ediowz4s 62 9 be be VB cord-331066-ediowz4s 62 10 assessed assess VBN cord-331066-ediowz4s 62 11 by by IN cord-331066-ediowz4s 62 12 the the DT cord-331066-ediowz4s 62 13 spectral spectral JJ cord-331066-ediowz4s 62 14 number number NN cord-331066-ediowz4s 62 15 n n NN cord-331066-ediowz4s 62 16 ' ' '' cord-331066-ediowz4s 62 17 for for IN cord-331066-ediowz4s 63 1 the the DT cord-331066-ediowz4s 63 2 peak peak NN cord-331066-ediowz4s 63 3 amplitude amplitude NN cord-331066-ediowz4s 63 4 f f NNP cord-331066-ediowz4s 64 1 II II NNP cord-331066-ediowz4s 64 2 ðq ðq NN cord-331066-ediowz4s 64 3 n n NN cord-331066-ediowz4s 64 4 0 0 CD cord-331066-ediowz4s 64 5 Þ þ NN cord-331066-ediowz4s 64 6 as as IN cord-331066-ediowz4s 64 7 while while IN cord-331066-ediowz4s 64 8 their -PRON- PRP$ cord-331066-ediowz4s 64 9 periods period NNS cord-331066-ediowz4s 64 10 in in IN cord-331066-ediowz4s 64 11 nucleotides nucleotide NNS cord-331066-ediowz4s 64 12 are be VBP cord-331066-ediowz4s 64 13 given give VBN cord-331066-ediowz4s 64 14 by by IN cord-331066-ediowz4s 64 15 The the DT cord-331066-ediowz4s 64 16 nucleotide nucleotide JJ cord-331066-ediowz4s 64 17 correlation correlation NN cord-331066-ediowz4s 64 18 functions function NNS cord-331066-ediowz4s 64 19 ( ( -LRB- cord-331066-ediowz4s 64 20 NCF NCF NNP cord-331066-ediowz4s 64 21 ) ) -RRB- cord-331066-ediowz4s 64 22 are be VBP cord-331066-ediowz4s 64 23 determined determine VBN cord-331066-ediowz4s 64 24 as as IN cord-331066-ediowz4s 64 25 , , , cord-331066-ediowz4s 64 26 The the DT cord-331066-ediowz4s 64 27 circular circular JJ cord-331066-ediowz4s 64 28 NCFs ncfs NN cord-331066-ediowz4s 64 29 used use VBN cord-331066-ediowz4s 64 30 in in IN cord-331066-ediowz4s 64 31 this this DT cord-331066-ediowz4s 64 32 article article NN cord-331066-ediowz4s 64 33 are be VBP cord-331066-ediowz4s 64 34 especially especially RB cord-331066-ediowz4s 64 35 suitable suitable JJ cord-331066-ediowz4s 64 36 for for IN cord-331066-ediowz4s 64 37 the the DT cord-331066-ediowz4s 64 38 detection detection NN cord-331066-ediowz4s 64 39 of of IN cord-331066-ediowz4s 64 40 periodic periodic JJ cord-331066-ediowz4s 64 41 patterns pattern NNS cord-331066-ediowz4s 64 42 . . . cord-331066-ediowz4s 65 1 Periodic periodic JJ cord-331066-ediowz4s 65 2 patterns pattern NNS cord-331066-ediowz4s 65 3 with with IN cord-331066-ediowz4s 65 4 a a DT cord-331066-ediowz4s 65 5 period period NN cord-331066-ediowz4s 65 6 p p TO cord-331066-ediowz4s 65 7 produce produce VBP cord-331066-ediowz4s 65 8 a a DT cord-331066-ediowz4s 65 9 series series NN cord-331066-ediowz4s 65 10 of of IN cord-331066-ediowz4s 65 11 equidistant equidistant JJ cord-331066-ediowz4s 65 12 peaks peak NNS cord-331066-ediowz4s 65 13 at at IN cord-331066-ediowz4s 65 14 the the DT cord-331066-ediowz4s 65 15 multiple multiple JJ cord-331066-ediowz4s 65 16 spacings spacing NNS cord-331066-ediowz4s 65 17 , , , cord-331066-ediowz4s 65 18 m m NNP cord-331066-ediowz4s 65 19 0 0 CD cord-331066-ediowz4s 65 20 ¼ ¼ NNP cord-331066-ediowz4s 65 21 kp kp NNP cord-331066-ediowz4s 65 22 , , , cord-331066-ediowz4s 65 23 k k NNP cord-331066-ediowz4s 65 24 ¼ ¼ NNP cord-331066-ediowz4s 65 25 1 1 CD cord-331066-ediowz4s 65 26 , , , cord-331066-ediowz4s 65 27 2 2 CD cord-331066-ediowz4s 65 28 , , , cord-331066-ediowz4s 65 29 … … NFP cord-331066-ediowz4s 66 1 The the DT cord-331066-ediowz4s 66 2 corresponding corresponding JJ cord-331066-ediowz4s 66 3 mean mean JJ cord-331066-ediowz4s 66 4 value value NN cord-331066-ediowz4s 66 5 is be VBZ cord-331066-ediowz4s 66 6 given give VBN cord-331066-ediowz4s 66 7 by by IN cord-331066-ediowz4s 66 8 The the DT cord-331066-ediowz4s 66 9 correlation correlation NN cord-331066-ediowz4s 66 10 functions function NNS cord-331066-ediowz4s 66 11 are be VBP cord-331066-ediowz4s 66 12 symmetrical symmetrical JJ cord-331066-ediowz4s 66 13 , , , cord-331066-ediowz4s 66 14 This this DT cord-331066-ediowz4s 66 15 allows allow VBZ cord-331066-ediowz4s 66 16 us -PRON- PRP cord-331066-ediowz4s 66 17 to to TO cord-331066-ediowz4s 66 18 restrict restrict VB cord-331066-ediowz4s 66 19 the the DT cord-331066-ediowz4s 66 20 analysis analysis NN cord-331066-ediowz4s 66 21 of of IN cord-331066-ediowz4s 66 22 NCF NCF NNP cord-331066-ediowz4s 66 23 from from IN cord-331066-ediowz4s 66 24 m m NNP cord-331066-ediowz4s 66 25 0 0 CD cord-331066-ediowz4s 66 26 ¼ ¼ NNP cord-331066-ediowz4s 66 27 1 1 CD cord-331066-ediowz4s 66 28 to to IN cord-331066-ediowz4s 66 29 N n CD cord-331066-ediowz4s 66 30 defined define VBN cord-331066-ediowz4s 66 31 by by IN cord-331066-ediowz4s 66 32 Equation equation NN cord-331066-ediowz4s 66 33 ( ( -LRB- cord-331066-ediowz4s 66 34 3 3 CD cord-331066-ediowz4s 66 35 ) ) -RRB- cord-331066-ediowz4s 66 36 . . . cord-331066-ediowz4s 67 1 The the DT cord-331066-ediowz4s 67 2 normalized normalized JJ cord-331066-ediowz4s 67 3 deviations deviation NNS cord-331066-ediowz4s 67 4 , , , cord-331066-ediowz4s 67 5 where where WRB cord-331066-ediowz4s 67 6 are be VBP cord-331066-ediowz4s 67 7 Gaussian gaussian JJ cord-331066-ediowz4s 67 8 for for IN cord-331066-ediowz4s 67 9 the the DT cord-331066-ediowz4s 67 10 random random JJ cord-331066-ediowz4s 67 11 sequences sequence NNS cord-331066-ediowz4s 67 12 . . . cord-331066-ediowz4s 68 1 Similarly similarly RB cord-331066-ediowz4s 68 2 to to IN cord-331066-ediowz4s 68 3 the the DT cord-331066-ediowz4s 68 4 sums sum NNS cord-331066-ediowz4s 68 5 defined define VBN cord-331066-ediowz4s 68 6 by by IN cord-331066-ediowz4s 68 7 Equations equation NNS cord-331066-ediowz4s 68 8 ( ( -LRB- cord-331066-ediowz4s 68 9 5)-(7 5)-(7 CD cord-331066-ediowz4s 68 10 ) ) -RRB- cord-331066-ediowz4s 68 11 , , , cord-331066-ediowz4s 68 12 it -PRON- PRP cord-331066-ediowz4s 68 13 is be VBZ cord-331066-ediowz4s 68 14 useful useful JJ cord-331066-ediowz4s 68 15 to to TO cord-331066-ediowz4s 68 16 introduce introduce VB cord-331066-ediowz4s 68 17 the the DT cord-331066-ediowz4s 68 18 combinations combination NNS cord-331066-ediowz4s 68 19 , , , cord-331066-ediowz4s 68 20 which which WDT cord-331066-ediowz4s 68 21 are be VBP cord-331066-ediowz4s 68 22 also also RB cord-331066-ediowz4s 68 23 Gaussian gaussian JJ cord-331066-ediowz4s 68 24 for for IN cord-331066-ediowz4s 68 25 the the DT cord-331066-ediowz4s 68 26 random random JJ cord-331066-ediowz4s 68 27 sequences sequence NNS cord-331066-ediowz4s 68 28 . . . cord-331066-ediowz4s 69 1 The the DT cord-331066-ediowz4s 69 2 correlation correlation NN cord-331066-ediowz4s 69 3 functions function NNS cord-331066-ediowz4s 69 4 and and CC cord-331066-ediowz4s 69 5 the the DT cord-331066-ediowz4s 69 6 DFT DFT NNP cord-331066-ediowz4s 69 7 structure structure NN cord-331066-ediowz4s 69 8 factors factor NNS cord-331066-ediowz4s 69 9 are be VBP cord-331066-ediowz4s 69 10 not not RB cord-331066-ediowz4s 69 11 independent independent JJ cord-331066-ediowz4s 69 12 and and CC cord-331066-ediowz4s 69 13 are be VBP cord-331066-ediowz4s 69 14 related relate VBN cord-331066-ediowz4s 69 15 by by IN cord-331066-ediowz4s 69 16 the the DT cord-331066-ediowz4s 69 17 Wiener Wiener NNP cord-331066-ediowz4s 69 18 - - HYPH cord-331066-ediowz4s 69 19 Khinchin Khinchin NNP cord-331066-ediowz4s 69 20 relationship relationship NN cord-331066-ediowz4s 69 21 , , , cord-331066-ediowz4s 69 22 The the DT cord-331066-ediowz4s 69 23 normalized normalized JJ cord-331066-ediowz4s 69 24 deviations deviation NNS cord-331066-ediowz4s 69 25 for for IN cord-331066-ediowz4s 69 26 NCF NCF NNP cord-331066-ediowz4s 69 27 can can MD cord-331066-ediowz4s 69 28 be be VB cord-331066-ediowz4s 69 29 expressed express VBN cord-331066-ediowz4s 69 30 as as IN cord-331066-ediowz4s 69 31 , , , cord-331066-ediowz4s 69 32 f f NNP cord-331066-ediowz4s 69 33 aa aa NNP cord-331066-ediowz4s 69 34 ðq ðq NN cord-331066-ediowz4s 69 35 n n NN cord-331066-ediowz4s 69 36 Þ þ NN cord-331066-ediowz4s 69 37 À à NN cord-331066-ediowz4s 69 38 1 1 CD cord-331066-ediowz4s 69 39 ð ð NN cord-331066-ediowz4s 69 40 Þ þ NN cord-331066-ediowz4s 69 41 e e NN cord-331066-ediowz4s 69 42 Àiq àiq NN cord-331066-ediowz4s 69 43 n n NN cord-331066-ediowz4s 69 44 m m NN cord-331066-ediowz4s 69 45 0 0 CD cord-331066-ediowz4s 70 1 : : : cord-331066-ediowz4s 70 2 These these DT cord-331066-ediowz4s 70 3 deviations deviation NNS cord-331066-ediowz4s 70 4 are be VBP cord-331066-ediowz4s 70 5 insensitive insensitive JJ cord-331066-ediowz4s 70 6 to to IN cord-331066-ediowz4s 70 7 the the DT cord-331066-ediowz4s 70 8 nucleotide nucleotide JJ cord-331066-ediowz4s 70 9 composition composition NN cord-331066-ediowz4s 70 10 and and CC cord-331066-ediowz4s 70 11 genome genome NN cord-331066-ediowz4s 70 12 length length NN cord-331066-ediowz4s 70 13 but but CC cord-331066-ediowz4s 70 14 may may MD cord-331066-ediowz4s 70 15 strongly strongly RB cord-331066-ediowz4s 70 16 depend depend VB cord-331066-ediowz4s 70 17 on on IN cord-331066-ediowz4s 70 18 the the DT cord-331066-ediowz4s 70 19 dominating dominate VBG cord-331066-ediowz4s 70 20 underlying underlie VBG cord-331066-ediowz4s 70 21 periodicities periodicity NNS cord-331066-ediowz4s 70 22 in in IN cord-331066-ediowz4s 70 23 the the DT cord-331066-ediowz4s 70 24 genomic genomic JJ cord-331066-ediowz4s 70 25 sequences sequence NNS cord-331066-ediowz4s 70 26 . . . cord-331066-ediowz4s 71 1 In in IN cord-331066-ediowz4s 71 2 the the DT cord-331066-ediowz4s 71 3 viral viral JJ cord-331066-ediowz4s 71 4 genomes genome NNS cord-331066-ediowz4s 71 5 this this DT cord-331066-ediowz4s 71 6 is be VBZ cord-331066-ediowz4s 71 7 the the DT cord-331066-ediowz4s 71 8 triplet triplet NN cord-331066-ediowz4s 71 9 periodicity periodicity NN cord-331066-ediowz4s 71 10 p p NN cord-331066-ediowz4s 71 11 ¼ ¼ NN cord-331066-ediowz4s 71 12 3 3 CD cord-331066-ediowz4s 71 13 inherent inherent JJ cord-331066-ediowz4s 71 14 to to IN cord-331066-ediowz4s 71 15 the the DT cord-331066-ediowz4s 71 16 protein protein NN cord-331066-ediowz4s 71 17 - - HYPH cord-331066-ediowz4s 71 18 coding code VBG cord-331066-ediowz4s 71 19 regions region NNS cord-331066-ediowz4s 71 20 ( ( -LRB- cord-331066-ediowz4s 71 21 for for IN cord-331066-ediowz4s 71 22 a a DT cord-331066-ediowz4s 71 23 review review NN cord-331066-ediowz4s 71 24 and and CC cord-331066-ediowz4s 71 25 further further JJ cord-331066-ediowz4s 71 26 references reference NNS cord-331066-ediowz4s 71 27 see see VBP cord-331066-ediowz4s 71 28 , , , cord-331066-ediowz4s 71 29 e.g. e.g. RB cord-331066-ediowz4s 71 30 Lobzin Lobzin NNP cord-331066-ediowz4s 71 31 & & CC cord-331066-ediowz4s 71 32 Chechetkin Chechetkin NNP cord-331066-ediowz4s 71 33 , , , cord-331066-ediowz4s 71 34 2000 2000 CD cord-331066-ediowz4s 71 35 ; ; : cord-331066-ediowz4s 71 36 Marhon Marhon NNP cord-331066-ediowz4s 71 37 & & CC cord-331066-ediowz4s 71 38 Kremer Kremer NNP cord-331066-ediowz4s 71 39 , , , cord-331066-ediowz4s 71 40 2011 2011 CD cord-331066-ediowz4s 71 41 ) ) -RRB- cord-331066-ediowz4s 71 42 . . . cord-331066-ediowz4s 72 1 The the DT cord-331066-ediowz4s 72 2 relationship relationship NN cord-331066-ediowz4s 72 3 defined define VBN cord-331066-ediowz4s 72 4 by by IN cord-331066-ediowz4s 72 5 Equation equation NN cord-331066-ediowz4s 72 6 ( ( -LRB- cord-331066-ediowz4s 72 7 27 27 CD cord-331066-ediowz4s 72 8 ) ) -RRB- cord-331066-ediowz4s 72 9 facilitates facilitate VBZ cord-331066-ediowz4s 72 10 the the DT cord-331066-ediowz4s 72 11 control control NN cord-331066-ediowz4s 72 12 of of IN cord-331066-ediowz4s 72 13 contribution contribution NN cord-331066-ediowz4s 72 14 from from IN cord-331066-ediowz4s 72 15 underlying underlie VBG cord-331066-ediowz4s 72 16 periodicities periodicity NNS cord-331066-ediowz4s 72 17 into into IN cord-331066-ediowz4s 72 18 the the DT cord-331066-ediowz4s 72 19 normalized normalized JJ cord-331066-ediowz4s 72 20 deviations deviation NNS cord-331066-ediowz4s 72 21 for for IN cord-331066-ediowz4s 72 22 NCF NCF NNP cord-331066-ediowz4s 72 23 by by IN cord-331066-ediowz4s 72 24 cutting cut VBG cord-331066-ediowz4s 72 25 - - HYPH cord-331066-ediowz4s 72 26 off off RP cord-331066-ediowz4s 72 27 dominating dominating JJ cord-331066-ediowz4s 72 28 peaks peak NNS cord-331066-ediowz4s 72 29 and and CC cord-331066-ediowz4s 72 30 re re JJ cord-331066-ediowz4s 72 31 - - JJ cord-331066-ediowz4s 72 32 normalizing normalize VBG cord-331066-ediowz4s 72 33 DFT dft NN cord-331066-ediowz4s 72 34 spectra spectrum NNS cord-331066-ediowz4s 72 35 . . . cord-331066-ediowz4s 73 1 Such such PDT cord-331066-ediowz4s 73 2 a a DT cord-331066-ediowz4s 73 3 procedure procedure NN cord-331066-ediowz4s 73 4 can can MD cord-331066-ediowz4s 73 5 be be VB cord-331066-ediowz4s 73 6 used use VBN cord-331066-ediowz4s 73 7 for for IN cord-331066-ediowz4s 73 8 detection detection NN cord-331066-ediowz4s 73 9 of of IN cord-331066-ediowz4s 73 10 the the DT cord-331066-ediowz4s 73 11 weaker weak JJR cord-331066-ediowz4s 73 12 longer long JJR cord-331066-ediowz4s 73 13 periodicities periodicity NNS cord-331066-ediowz4s 73 14 on on IN cord-331066-ediowz4s 73 15 the the DT cord-331066-ediowz4s 73 16 background background NN cord-331066-ediowz4s 73 17 of of IN cord-331066-ediowz4s 73 18 strong strong JJ cord-331066-ediowz4s 73 19 short short JJ cord-331066-ediowz4s 73 20 periodicities periodicity NNS cord-331066-ediowz4s 73 21 . . . cord-331066-ediowz4s 74 1 Throughout throughout IN cord-331066-ediowz4s 74 2 this this DT cord-331066-ediowz4s 74 3 article article NN cord-331066-ediowz4s 74 4 , , , cord-331066-ediowz4s 74 5 we -PRON- PRP cord-331066-ediowz4s 74 6 will will MD cord-331066-ediowz4s 74 7 use use VB cord-331066-ediowz4s 74 8 the the DT cord-331066-ediowz4s 74 9 standard standard JJ cord-331066-ediowz4s 74 10 statistical statistical JJ cord-331066-ediowz4s 74 11 criteria criterion NNS cord-331066-ediowz4s 74 12 corresponding correspond VBG cord-331066-ediowz4s 74 13 to to IN cord-331066-ediowz4s 74 14 the the DT cord-331066-ediowz4s 74 15 probability probability NN cord-331066-ediowz4s 74 16 Pr pr NN cord-331066-ediowz4s 74 17 ¼ ¼ CD cord-331066-ediowz4s 74 18 0.05 0.05 CD cord-331066-ediowz4s 74 19 . . . cord-331066-ediowz4s 75 1 For for IN cord-331066-ediowz4s 75 2 the the DT cord-331066-ediowz4s 75 3 random random JJ cord-331066-ediowz4s 75 4 sequences sequence NNS cord-331066-ediowz4s 75 5 , , , cord-331066-ediowz4s 75 6 the the DT cord-331066-ediowz4s 75 7 statistics statistic NNS cord-331066-ediowz4s 75 8 for for IN cord-331066-ediowz4s 75 9 the the DT cord-331066-ediowz4s 75 10 DFT DFT NNP cord-331066-ediowz4s 75 11 and and CC cord-331066-ediowz4s 75 12 DDFT DDFT NNP cord-331066-ediowz4s 75 13 normalized normalize VBN cord-331066-ediowz4s 75 14 harmonics harmonic NNS cord-331066-ediowz4s 75 15 defined define VBN cord-331066-ediowz4s 75 16 by by IN cord-331066-ediowz4s 75 17 Equations equation NNS cord-331066-ediowz4s 75 18 ( ( -LRB- cord-331066-ediowz4s 75 19 4 4 CD cord-331066-ediowz4s 75 20 ) ) -RRB- cord-331066-ediowz4s 75 21 and and CC cord-331066-ediowz4s 75 22 ( ( -LRB- cord-331066-ediowz4s 75 23 12 12 CD cord-331066-ediowz4s 75 24 ) ) -RRB- cord-331066-ediowz4s 75 25 is be VBZ cord-331066-ediowz4s 75 26 Rayleighian Rayleighian NNP cord-331066-ediowz4s 75 27 , , , cord-331066-ediowz4s 75 28 whereas whereas IN cord-331066-ediowz4s 75 29 the the DT cord-331066-ediowz4s 75 30 statistics statistic NNS cord-331066-ediowz4s 75 31 for for IN cord-331066-ediowz4s 75 32 the the DT cord-331066-ediowz4s 75 33 normalized normalized JJ cord-331066-ediowz4s 75 34 deviations deviation NNS cord-331066-ediowz4s 75 35 defined define VBN cord-331066-ediowz4s 75 36 by by IN cord-331066-ediowz4s 75 37 Equations equation NNS cord-331066-ediowz4s 75 38 ( ( -LRB- cord-331066-ediowz4s 75 39 20 20 CD cord-331066-ediowz4s 75 40 ) ) -RRB- cord-331066-ediowz4s 75 41 and and CC cord-331066-ediowz4s 75 42 ( ( -LRB- cord-331066-ediowz4s 75 43 22)-(24 22)-(24 CD cord-331066-ediowz4s 75 44 ) ) -RRB- cord-331066-ediowz4s 75 45 is be VBZ cord-331066-ediowz4s 75 46 Gaussian gaussian JJ cord-331066-ediowz4s 75 47 . . . cord-331066-ediowz4s 76 1 To to TO cord-331066-ediowz4s 76 2 study study VB cord-331066-ediowz4s 76 3 the the DT cord-331066-ediowz4s 76 4 distribution distribution NN cord-331066-ediowz4s 76 5 of of IN cord-331066-ediowz4s 76 6 periodic periodic JJ cord-331066-ediowz4s 76 7 patterns pattern NNS cord-331066-ediowz4s 76 8 over over IN cord-331066-ediowz4s 76 9 the the DT cord-331066-ediowz4s 76 10 genome genome NN cord-331066-ediowz4s 76 11 , , , cord-331066-ediowz4s 76 12 we -PRON- PRP cord-331066-ediowz4s 76 13 will will MD cord-331066-ediowz4s 76 14 use use VB cord-331066-ediowz4s 76 15 a a DT cord-331066-ediowz4s 76 16 set set NN cord-331066-ediowz4s 76 17 of of IN cord-331066-ediowz4s 76 18 nonoverlapping nonoverlappe VBG cord-331066-ediowz4s 76 19 windows window NNS cord-331066-ediowz4s 76 20 of of IN cord-331066-ediowz4s 76 21 width width NN cord-331066-ediowz4s 76 22 w. w. NNP cord-331066-ediowz4s 76 23 Averaging Averaging NNP cord-331066-ediowz4s 76 24 of of IN cord-331066-ediowz4s 76 25 the the DT cord-331066-ediowz4s 76 26 DFT DFT NNP cord-331066-ediowz4s 76 27 spectra spectra NN cord-331066-ediowz4s 76 28 over over IN cord-331066-ediowz4s 76 29 the the DT cord-331066-ediowz4s 76 30 windows window NNS cord-331066-ediowz4s 76 31 provides provide VBZ cord-331066-ediowz4s 76 32 the the DT cord-331066-ediowz4s 76 33 corresponding correspond VBG cord-331066-ediowz4s 76 34 periodogram periodogram NN cord-331066-ediowz4s 76 35 , , , cord-331066-ediowz4s 76 36 while while IN cord-331066-ediowz4s 76 37 averaging average VBG cord-331066-ediowz4s 76 38 of of IN cord-331066-ediowz4s 76 39 the the DT cord-331066-ediowz4s 76 40 normalized normalized JJ cord-331066-ediowz4s 76 41 deviations deviation NNS cord-331066-ediowz4s 76 42 for for IN cord-331066-ediowz4s 76 43 NCF NCF NNP cord-331066-ediowz4s 76 44 over over IN cord-331066-ediowz4s 76 45 the the DT cord-331066-ediowz4s 76 46 windows window NNS cord-331066-ediowz4s 76 47 provides provide VBZ cord-331066-ediowz4s 76 48 the the DT cord-331066-ediowz4s 76 49 corresponding correspond VBG cord-331066-ediowz4s 76 50 correlogram correlogram NN cord-331066-ediowz4s 76 51 ( ( -LRB- cord-331066-ediowz4s 76 52 see see UH cord-331066-ediowz4s 76 53 , , , cord-331066-ediowz4s 76 54 e.g. e.g. RB cord-331066-ediowz4s 76 55 Marple Marple NNP cord-331066-ediowz4s 76 56 , , , cord-331066-ediowz4s 76 57 1987 1987 CD cord-331066-ediowz4s 76 58 ) ) -RRB- cord-331066-ediowz4s 76 59 . . . cord-331066-ediowz4s 77 1 Averaging average VBG cord-331066-ediowz4s 77 2 over over IN cord-331066-ediowz4s 77 3 windows window NNS cord-331066-ediowz4s 77 4 diminishes diminish VBZ cord-331066-ediowz4s 77 5 the the DT cord-331066-ediowz4s 77 6 effects effect NNS cord-331066-ediowz4s 77 7 of of IN cord-331066-ediowz4s 77 8 indels indel NNS cord-331066-ediowz4s 77 9 on on IN cord-331066-ediowz4s 77 10 the the DT cord-331066-ediowz4s 77 11 periodicity periodicity NN cord-331066-ediowz4s 77 12 phasing phase VBG cord-331066-ediowz4s 77 13 . . . cord-331066-ediowz4s 78 1 The the DT cord-331066-ediowz4s 78 2 motifs motif NNS cord-331066-ediowz4s 78 3 related relate VBN cord-331066-ediowz4s 78 4 to to IN cord-331066-ediowz4s 78 5 quasi quasi JJ cord-331066-ediowz4s 78 6 - - JJ cord-331066-ediowz4s 78 7 periodic periodic JJ cord-331066-ediowz4s 78 8 patterns pattern NNS cord-331066-ediowz4s 78 9 are be VBP cord-331066-ediowz4s 78 10 presumably presumably RB cord-331066-ediowz4s 78 11 the the DT cord-331066-ediowz4s 78 12 most most RBS cord-331066-ediowz4s 78 13 important important JJ cord-331066-ediowz4s 78 14 for for IN cord-331066-ediowz4s 78 15 practical practical JJ cord-331066-ediowz4s 78 16 applications application NNS cord-331066-ediowz4s 78 17 . . . cord-331066-ediowz4s 79 1 For for IN cord-331066-ediowz4s 79 2 their -PRON- PRP$ cord-331066-ediowz4s 79 3 reconstruction reconstruction NN cord-331066-ediowz4s 79 4 , , , cord-331066-ediowz4s 79 5 we -PRON- PRP cord-331066-ediowz4s 79 6 developed develop VBD cord-331066-ediowz4s 79 7 a a DT cord-331066-ediowz4s 79 8 method method NN cord-331066-ediowz4s 79 9 of of IN cord-331066-ediowz4s 79 10 transitional transitional JJ cord-331066-ediowz4s 79 11 automorphic automorphic JJ cord-331066-ediowz4s 79 12 mapping mapping NN cord-331066-ediowz4s 79 13 of of IN cord-331066-ediowz4s 79 14 the the DT cord-331066-ediowz4s 79 15 genome genome NN cord-331066-ediowz4s 79 16 on on IN cord-331066-ediowz4s 79 17 itself -PRON- PRP cord-331066-ediowz4s 79 18 ( ( -LRB- cord-331066-ediowz4s 79 19 TAMGI TAMGI NNP cord-331066-ediowz4s 79 20 ) ) -RRB- cord-331066-ediowz4s 79 21 . . . cord-331066-ediowz4s 80 1 The the DT cord-331066-ediowz4s 80 2 algorithm algorithm NN cord-331066-ediowz4s 80 3 for for IN cord-331066-ediowz4s 80 4 TAMGI TAMGI NNP cord-331066-ediowz4s 80 5 is be VBZ cord-331066-ediowz4s 80 6 as as IN cord-331066-ediowz4s 80 7 follows follow VBZ cord-331066-ediowz4s 80 8 . . . cord-331066-ediowz4s 81 1 Let let VB cord-331066-ediowz4s 81 2 a a DT cord-331066-ediowz4s 81 3 step step NN cord-331066-ediowz4s 81 4 length length NN cord-331066-ediowz4s 81 5 s s NNS cord-331066-ediowz4s 81 6 be be VB cord-331066-ediowz4s 81 7 chosen choose VBN cord-331066-ediowz4s 81 8 ( ( -LRB- cord-331066-ediowz4s 81 9 equal equal JJ cord-331066-ediowz4s 81 10 to to IN cord-331066-ediowz4s 81 11 the the DT cord-331066-ediowz4s 81 12 detected detected JJ cord-331066-ediowz4s 81 13 period period NN cord-331066-ediowz4s 81 14 of of IN cord-331066-ediowz4s 81 15 periodic periodic JJ cord-331066-ediowz4s 81 16 patterns pattern NNS cord-331066-ediowz4s 81 17 in in IN cord-331066-ediowz4s 81 18 the the DT cord-331066-ediowz4s 81 19 problem problem NN cord-331066-ediowz4s 81 20 concerned concern VBN cord-331066-ediowz4s 81 21 ) ) -RRB- cord-331066-ediowz4s 81 22 . . . cord-331066-ediowz4s 82 1 Then then RB cord-331066-ediowz4s 82 2 , , , cord-331066-ediowz4s 82 3 the the DT cord-331066-ediowz4s 82 4 pairs pair NNS cord-331066-ediowz4s 82 5 of of IN cord-331066-ediowz4s 82 6 nucleotides nucleotide NNS cord-331066-ediowz4s 82 7 ( ( -LRB- cord-331066-ediowz4s 82 8 N N NNP cord-331066-ediowz4s 82 9 m m NNP cord-331066-ediowz4s 82 10 , , , cord-331066-ediowz4s 82 11 N N NNP cord-331066-ediowz4s 82 12 m m NN cord-331066-ediowz4s 82 13 þ þ NNP cord-331066-ediowz4s 82 14 s s NNP cord-331066-ediowz4s 82 15 ) ) -RRB- cord-331066-ediowz4s 82 16 separated separate VBN cord-331066-ediowz4s 82 17 by by IN cord-331066-ediowz4s 82 18 the the DT cord-331066-ediowz4s 82 19 step step NN cord-331066-ediowz4s 82 20 s s NNS cord-331066-ediowz4s 82 21 are be VBP cord-331066-ediowz4s 82 22 mutually mutually RB cord-331066-ediowz4s 82 23 compared compare VBN cord-331066-ediowz4s 82 24 when when WRB cord-331066-ediowz4s 82 25 moving move VBG cord-331066-ediowz4s 82 26 one one CD cord-331066-ediowz4s 82 27 - - HYPH cord-331066-ediowz4s 82 28 by by IN cord-331066-ediowz4s 82 29 - - HYPH cord-331066-ediowz4s 82 30 one one CD cord-331066-ediowz4s 82 31 site site NN cord-331066-ediowz4s 82 32 m m NN cord-331066-ediowz4s 82 33 along along IN cord-331066-ediowz4s 82 34 the the DT cord-331066-ediowz4s 82 35 genomic genomic JJ cord-331066-ediowz4s 82 36 sequence sequence NN cord-331066-ediowz4s 82 37 . . . cord-331066-ediowz4s 83 1 If if IN cord-331066-ediowz4s 83 2 both both DT cord-331066-ediowz4s 83 3 nucleotides nucleotide NNS cord-331066-ediowz4s 83 4 belong belong VBP cord-331066-ediowz4s 83 5 to to IN cord-331066-ediowz4s 83 6 the the DT cord-331066-ediowz4s 83 7 same same JJ cord-331066-ediowz4s 83 8 type type NN cord-331066-ediowz4s 83 9 , , , cord-331066-ediowz4s 83 10 they -PRON- PRP cord-331066-ediowz4s 83 11 both both DT cord-331066-ediowz4s 83 12 are be VBP cord-331066-ediowz4s 83 13 retained retain VBN cord-331066-ediowz4s 83 14 in in IN cord-331066-ediowz4s 83 15 the the DT cord-331066-ediowz4s 83 16 genomic genomic JJ cord-331066-ediowz4s 83 17 sequence sequence NN cord-331066-ediowz4s 83 18 ; ; : cord-331066-ediowz4s 83 19 otherwise otherwise RB cord-331066-ediowz4s 83 20 , , , cord-331066-ediowz4s 83 21 the the DT cord-331066-ediowz4s 83 22 nucleotide nucleotide JJ cord-331066-ediowz4s 83 23 N N NNP cord-331066-ediowz4s 83 24 m m NNP cord-331066-ediowz4s 83 25 is be VBZ cord-331066-ediowz4s 83 26 replaced replace VBN cord-331066-ediowz4s 83 27 by by IN cord-331066-ediowz4s 83 28 void void JJ cord-331066-ediowz4s 83 29 ( ( -LRB- cord-331066-ediowz4s 83 30 denoted denote VBN cord-331066-ediowz4s 83 31 traditionally traditionally RB cord-331066-ediowz4s 83 32 by by IN cord-331066-ediowz4s 83 33 the the DT cord-331066-ediowz4s 83 34 hyphen hyphen NN cord-331066-ediowz4s 83 35 ) ) -RRB- cord-331066-ediowz4s 83 36 . . . cord-331066-ediowz4s 84 1 Thus thus RB cord-331066-ediowz4s 84 2 , , , cord-331066-ediowz4s 84 3 the the DT cord-331066-ediowz4s 84 4 N n NN cord-331066-ediowz4s 84 5 m m NN cord-331066-ediowz4s 84 6 th th XX cord-331066-ediowz4s 84 7 nucleotide nucleotide NN cord-331066-ediowz4s 84 8 will will MD cord-331066-ediowz4s 84 9 be be VB cord-331066-ediowz4s 84 10 retained retain VBN cord-331066-ediowz4s 84 11 if if IN cord-331066-ediowz4s 84 12 it -PRON- PRP cord-331066-ediowz4s 84 13 has have VBZ cord-331066-ediowz4s 84 14 at at RB cord-331066-ediowz4s 84 15 least least RBS cord-331066-ediowz4s 84 16 one one CD cord-331066-ediowz4s 84 17 neighbor neighbor NN cord-331066-ediowz4s 84 18 N N NNP cord-331066-ediowz4s 84 19 ms ms NNP cord-331066-ediowz4s 84 20 or or CC cord-331066-ediowz4s 84 21 N N NNP cord-331066-ediowz4s 84 22 m m NNP cord-331066-ediowz4s 84 23 þ þ NNP cord-331066-ediowz4s 84 24 s s NNP cord-331066-ediowz4s 84 25 of of IN cord-331066-ediowz4s 84 26 the the DT cord-331066-ediowz4s 84 27 same same JJ cord-331066-ediowz4s 84 28 type type NN cord-331066-ediowz4s 84 29 and and CC cord-331066-ediowz4s 84 30 be be VB cord-331066-ediowz4s 84 31 replaced replace VBN cord-331066-ediowz4s 84 32 by by IN cord-331066-ediowz4s 84 33 void void NN cord-331066-ediowz4s 84 34 otherwise otherwise RB cord-331066-ediowz4s 84 35 . . . cord-331066-ediowz4s 85 1 The the DT cord-331066-ediowz4s 85 2 resulting result VBG cord-331066-ediowz4s 85 3 sequence sequence NN cord-331066-ediowz4s 85 4 after after IN cord-331066-ediowz4s 85 5 TAMGI TAMGI NNP cord-331066-ediowz4s 85 6 is be VBZ cord-331066-ediowz4s 85 7 composed compose VBN cord-331066-ediowz4s 85 8 of of IN cord-331066-ediowz4s 85 9 the the DT cord-331066-ediowz4s 85 10 nucleotides nucleotide NNS cord-331066-ediowz4s 85 11 of of IN cord-331066-ediowz4s 85 12 four four CD cord-331066-ediowz4s 85 13 types type NNS cord-331066-ediowz4s 85 14 ( ( -LRB- cord-331066-ediowz4s 85 15 A A NNP cord-331066-ediowz4s 85 16 , , , cord-331066-ediowz4s 85 17 C C NNP cord-331066-ediowz4s 85 18 , , , cord-331066-ediowz4s 85 19 G G NNP cord-331066-ediowz4s 85 20 , , , cord-331066-ediowz4s 85 21 T T NNP cord-331066-ediowz4s 85 22 ) ) -RRB- cord-331066-ediowz4s 85 23 and and CC cord-331066-ediowz4s 85 24 the the DT cord-331066-ediowz4s 85 25 hyphens hyphen NNS cord-331066-ediowz4s 85 26 ' ' POS cord-331066-ediowz4s 85 27 - - HYPH cord-331066-ediowz4s 85 28 ' ' `` cord-331066-ediowz4s 85 29 denoting denote VBG cord-331066-ediowz4s 85 30 voids void NNS cord-331066-ediowz4s 85 31 . . . cord-331066-ediowz4s 86 1 Further further JJ cord-331066-ediowz4s 86 2 analysis analysis NN cord-331066-ediowz4s 86 3 is be VBZ cord-331066-ediowz4s 86 4 reduced reduce VBN cord-331066-ediowz4s 86 5 to to IN cord-331066-ediowz4s 86 6 the the DT cord-331066-ediowz4s 86 7 enumeration enumeration NN cord-331066-ediowz4s 86 8 of of IN cord-331066-ediowz4s 86 9 all all DT cord-331066-ediowz4s 86 10 complete complete JJ cord-331066-ediowz4s 86 11 words word NNS cord-331066-ediowz4s 86 12 of of IN cord-331066-ediowz4s 86 13 length length NN cord-331066-ediowz4s 87 1 k k NNP cord-331066-ediowz4s 88 1 ( ( -LRB- cord-331066-ediowz4s 88 2 k k NNP cord-331066-ediowz4s 88 3 - - HYPH cord-331066-ediowz4s 88 4 mers mers NNP cord-331066-ediowz4s 88 5 ) ) -RRB- cord-331066-ediowz4s 88 6 composed compose VBN cord-331066-ediowz4s 88 7 only only RB cord-331066-ediowz4s 88 8 of of IN cord-331066-ediowz4s 88 9 nucleotides nucleotide NNS cord-331066-ediowz4s 88 10 ( ( -LRB- cord-331066-ediowz4s 88 11 voids void NNS cord-331066-ediowz4s 88 12 within within IN cord-331066-ediowz4s 88 13 the the DT cord-331066-ediowz4s 88 14 complete complete JJ cord-331066-ediowz4s 88 15 words word NNS cord-331066-ediowz4s 88 16 are be VBP cord-331066-ediowz4s 88 17 prohibited prohibit VBN cord-331066-ediowz4s 88 18 ) ) -RRB- cord-331066-ediowz4s 88 19 and and CC cord-331066-ediowz4s 88 20 surrounded surround VBN cord-331066-ediowz4s 88 21 by by IN cord-331066-ediowz4s 88 22 the the DT cord-331066-ediowz4s 88 23 voids void NNS cord-331066-ediowz4s 88 24 ' ' POS cord-331066-ediowz4s 88 25 - - : cord-331066-ediowz4s 88 26 ' ' '' cord-331066-ediowz4s 88 27 at at IN cord-331066-ediowz4s 88 28 5 5 CD cord-331066-ediowz4s 88 29 0 0 CD cord-331066-ediowz4s 88 30 -and -and SYM cord-331066-ediowz4s 88 31 3 3 CD cord-331066-ediowz4s 88 32 0 0 CD cord-331066-ediowz4s 88 33 -ends -end NNS cord-331066-ediowz4s 88 34 , , . cord-331066-ediowz4s 89 1 -N -N NFP cord-331066-ediowz4s 89 2 k k XX cord-331066-ediowz4s 89 3 - - HYPH cord-331066-ediowz4s 89 4 . . . cord-331066-ediowz4s 90 1 By by IN cord-331066-ediowz4s 90 2 definition definition NN cord-331066-ediowz4s 90 3 , , , cord-331066-ediowz4s 90 4 the the DT cord-331066-ediowz4s 90 5 complete complete JJ cord-331066-ediowz4s 90 6 words word NNS cord-331066-ediowz4s 90 7 are be VBP cord-331066-ediowz4s 90 8 nonoverlapping nonoverlappe VBG cord-331066-ediowz4s 90 9 . . . cord-331066-ediowz4s 91 1 At at IN cord-331066-ediowz4s 91 2 the the DT cord-331066-ediowz4s 91 3 next next JJ cord-331066-ediowz4s 91 4 stage stage NN cord-331066-ediowz4s 91 5 , , , cord-331066-ediowz4s 91 6 the the DT cord-331066-ediowz4s 91 7 mismatches mismatch NNS cord-331066-ediowz4s 91 8 to to IN cord-331066-ediowz4s 91 9 the the DT cord-331066-ediowz4s 91 10 complete complete JJ cord-331066-ediowz4s 91 11 words word NNS cord-331066-ediowz4s 91 12 can can MD cord-331066-ediowz4s 91 13 be be VB cord-331066-ediowz4s 91 14 studied study VBN cord-331066-ediowz4s 91 15 . . . cord-331066-ediowz4s 92 1 If if IN cord-331066-ediowz4s 92 2 the the DT cord-331066-ediowz4s 92 3 presence presence NN cord-331066-ediowz4s 92 4 of of IN cord-331066-ediowz4s 92 5 periodic periodic JJ cord-331066-ediowz4s 92 6 patterns pattern NNS cord-331066-ediowz4s 92 7 is be VBZ cord-331066-ediowz4s 92 8 ensured ensure VBN cord-331066-ediowz4s 92 9 , , , cord-331066-ediowz4s 92 10 e.g. e.g. RB cord-331066-ediowz4s 92 11 by by IN cord-331066-ediowz4s 92 12 DFT DFT NNP cord-331066-ediowz4s 92 13 or or CC cord-331066-ediowz4s 92 14 DDFT DDFT NNP cord-331066-ediowz4s 92 15 , , , cord-331066-ediowz4s 92 16 TAMGI TAMGI NNP cord-331066-ediowz4s 92 17 with with IN cord-331066-ediowz4s 92 18 the the DT cord-331066-ediowz4s 92 19 step step NN cord-331066-ediowz4s 92 20 s s NNS cord-331066-ediowz4s 92 21 equal equal JJ cord-331066-ediowz4s 92 22 to to IN cord-331066-ediowz4s 92 23 the the DT cord-331066-ediowz4s 92 24 corresponding corresponding JJ cord-331066-ediowz4s 92 25 period period NN cord-331066-ediowz4s 93 1 p p NNP cord-331066-ediowz4s 93 2 provides provide VBZ cord-331066-ediowz4s 93 3 a a DT cord-331066-ediowz4s 93 4 sequence sequence NN cord-331066-ediowz4s 93 5 enriched enrich VBN cord-331066-ediowz4s 93 6 by by IN cord-331066-ediowz4s 93 7 the the DT cord-331066-ediowz4s 93 8 periodic periodic JJ cord-331066-ediowz4s 93 9 patterns pattern NNS cord-331066-ediowz4s 93 10 . . . cord-331066-ediowz4s 94 1 Thus thus RB cord-331066-ediowz4s 94 2 , , , cord-331066-ediowz4s 94 3 TAMGI TAMGI NNP cord-331066-ediowz4s 94 4 contains contain VBZ cord-331066-ediowz4s 94 5 the the DT cord-331066-ediowz4s 94 6 most most RBS cord-331066-ediowz4s 94 7 frequent frequent JJ cord-331066-ediowz4s 94 8 motifs motif NNS cord-331066-ediowz4s 94 9 related relate VBN cord-331066-ediowz4s 94 10 to to IN cord-331066-ediowz4s 94 11 quasiperiodic quasiperiodic JJ cord-331066-ediowz4s 94 12 patterns pattern NNS cord-331066-ediowz4s 94 13 and and CC cord-331066-ediowz4s 94 14 provides provide VBZ cord-331066-ediowz4s 94 15 their -PRON- PRP$ cord-331066-ediowz4s 94 16 distribution distribution NN cord-331066-ediowz4s 94 17 over over IN cord-331066-ediowz4s 94 18 the the DT cord-331066-ediowz4s 94 19 genome genome NN cord-331066-ediowz4s 94 20 . . . cord-331066-ediowz4s 95 1 As as IN cord-331066-ediowz4s 95 2 TAMGI TAMGI NNP cord-331066-ediowz4s 95 3 contains contain VBZ cord-331066-ediowz4s 95 4 also also RB cord-331066-ediowz4s 95 5 the the DT cord-331066-ediowz4s 95 6 quasi quasi JJ cord-331066-ediowz4s 95 7 - - JJ cord-331066-ediowz4s 95 8 random random JJ cord-331066-ediowz4s 95 9 fraction fraction NN cord-331066-ediowz4s 95 10 , , , cord-331066-ediowz4s 95 11 the the DT cord-331066-ediowz4s 95 12 latter latter JJ cord-331066-ediowz4s 95 13 can can MD cord-331066-ediowz4s 95 14 be be VB cord-331066-ediowz4s 95 15 partially partially RB cord-331066-ediowz4s 95 16 filtered filter VBN cord-331066-ediowz4s 95 17 out out RP cord-331066-ediowz4s 95 18 by by IN cord-331066-ediowz4s 95 19 combining combine VBG cord-331066-ediowz4s 95 20 TAMGI TAMGI NNP cord-331066-ediowz4s 95 21 with with IN cord-331066-ediowz4s 95 22 the the DT cord-331066-ediowz4s 95 23 steps step NNS cord-331066-ediowz4s 95 24 s s POS cord-331066-ediowz4s 95 25 and and CC cord-331066-ediowz4s 95 26 2 2 CD cord-331066-ediowz4s 95 27 s. s. NNP cord-331066-ediowz4s 96 1 The the DT cord-331066-ediowz4s 96 2 TAMGI TAMGI NNP cord-331066-ediowz4s 96 3 method method NN cord-331066-ediowz4s 96 4 is be VBZ cord-331066-ediowz4s 96 5 robust robust JJ cord-331066-ediowz4s 96 6 with with IN cord-331066-ediowz4s 96 7 respect respect NN cord-331066-ediowz4s 96 8 to to IN cord-331066-ediowz4s 96 9 indels indel NNS cord-331066-ediowz4s 96 10 but but CC cord-331066-ediowz4s 96 11 may may MD cord-331066-ediowz4s 96 12 depend depend VB cord-331066-ediowz4s 96 13 on on IN cord-331066-ediowz4s 96 14 the the DT cord-331066-ediowz4s 96 15 nucleotide nucleotide JJ cord-331066-ediowz4s 96 16 content content NN cord-331066-ediowz4s 96 17 and and CC cord-331066-ediowz4s 96 18 underlying underlie VBG cord-331066-ediowz4s 96 19 short short JJ cord-331066-ediowz4s 96 20 periodicities periodicity NNS cord-331066-ediowz4s 96 21 . . . cord-331066-ediowz4s 97 1 Generally generally RB cord-331066-ediowz4s 97 2 , , , cord-331066-ediowz4s 97 3 TAMGI TAMGI NNP cord-331066-ediowz4s 97 4 may may MD cord-331066-ediowz4s 97 5 also also RB cord-331066-ediowz4s 97 6 be be VB cord-331066-ediowz4s 97 7 extended extend VBN cord-331066-ediowz4s 97 8 to to IN cord-331066-ediowz4s 97 9 noninteger noninteger NNP cord-331066-ediowz4s 97 10 steps step NNS cord-331066-ediowz4s 97 11 s s PRP cord-331066-ediowz4s 97 12 by by IN cord-331066-ediowz4s 97 13 the the DT cord-331066-ediowz4s 97 14 best good JJS cord-331066-ediowz4s 97 15 integer integ JJR cord-331066-ediowz4s 97 16 approximation approximation NN cord-331066-ediowz4s 97 17 of of IN cord-331066-ediowz4s 97 18 transitional transitional JJ cord-331066-ediowz4s 97 19 mapping mapping NN cord-331066-ediowz4s 97 20 with with IN cord-331066-ediowz4s 97 21 noninteger noninteger NNP cord-331066-ediowz4s 97 22 s. s. NNP cord-331066-ediowz4s 98 1 The the DT cord-331066-ediowz4s 98 2 latter latter JJ cord-331066-ediowz4s 98 3 can can MD cord-331066-ediowz4s 98 4 be be VB cord-331066-ediowz4s 98 5 obtained obtain VBN cord-331066-ediowz4s 98 6 using use VBG cord-331066-ediowz4s 98 7 a a DT cord-331066-ediowz4s 98 8 set set NN cord-331066-ediowz4s 98 9 of of IN cord-331066-ediowz4s 98 10 chains chain NNS cord-331066-ediowz4s 98 11 ( ( -LRB- cord-331066-ediowz4s 98 12 N n CD cord-331066-ediowz4s 98 13 1 1 CD cord-331066-ediowz4s 98 14 _SP cord-331066-ediowz4s 98 15 where where WRB cord-331066-ediowz4s 98 16 fksg fksg NNP cord-331066-ediowz4s 98 17 means mean VBZ cord-331066-ediowz4s 98 18 rounding round VBG cord-331066-ediowz4s 98 19 to to IN cord-331066-ediowz4s 98 20 the the DT cord-331066-ediowz4s 98 21 nearest near JJS cord-331066-ediowz4s 98 22 integer integer NN cord-331066-ediowz4s 98 23 and and CC cord-331066-ediowz4s 98 24 f(k f(k NNP cord-331066-ediowz4s 98 25 max max NN cord-331066-ediowz4s 98 26 þ1)sg þ1)sg NNP cord-331066-ediowz4s 98 27 < < XX cord-331066-ediowz4s 98 28 M. M. NNP cord-331066-ediowz4s 99 1 The the DT cord-331066-ediowz4s 99 2 choice choice NN cord-331066-ediowz4s 99 3 of of IN cord-331066-ediowz4s 99 4 consecutive consecutive JJ cord-331066-ediowz4s 99 5 pairs pair NNS cord-331066-ediowz4s 99 6 in in IN cord-331066-ediowz4s 99 7 the the DT cord-331066-ediowz4s 99 8 chains chain NNS cord-331066-ediowz4s 99 9 is be VBZ cord-331066-ediowz4s 99 10 performed perform VBN cord-331066-ediowz4s 99 11 by by IN cord-331066-ediowz4s 99 12 the the DT cord-331066-ediowz4s 99 13 algorithm algorithm NN cord-331066-ediowz4s 99 14 similar similar JJ cord-331066-ediowz4s 99 15 to to IN cord-331066-ediowz4s 99 16 that that DT cord-331066-ediowz4s 99 17 as as IN cord-331066-ediowz4s 99 18 described describe VBN cord-331066-ediowz4s 99 19 above above RB cord-331066-ediowz4s 99 20 . . . cord-331066-ediowz4s 100 1 The the DT cord-331066-ediowz4s 100 2 abundance abundance NN cord-331066-ediowz4s 100 3 of of IN cord-331066-ediowz4s 100 4 quasi quasi JJ cord-331066-ediowz4s 100 5 - - JJ cord-331066-ediowz4s 100 6 periodic periodic JJ cord-331066-ediowz4s 100 7 patterns pattern NNS cord-331066-ediowz4s 100 8 in in IN cord-331066-ediowz4s 100 9 the the DT cord-331066-ediowz4s 100 10 genomic genomic JJ cord-331066-ediowz4s 100 11 DNA DNA NNP cord-331066-ediowz4s 100 12 / / SYM cord-331066-ediowz4s 100 13 RNA RNA NNP cord-331066-ediowz4s 100 14 sequences sequence NNS cord-331066-ediowz4s 100 15 can can MD cord-331066-ediowz4s 100 16 be be VB cord-331066-ediowz4s 100 17 assessed assess VBN cord-331066-ediowz4s 100 18 by by IN cord-331066-ediowz4s 100 19 the the DT cord-331066-ediowz4s 100 20 spectral spectral JJ cord-331066-ediowz4s 100 21 entropy entropy NN cord-331066-ediowz4s 100 22 ( ( -LRB- cord-331066-ediowz4s 100 23 Balakirev Balakirev NNP cord-331066-ediowz4s 100 24 et et NNP cord-331066-ediowz4s 100 25 al al NNP cord-331066-ediowz4s 100 26 . . NNP cord-331066-ediowz4s 100 27 , , , cord-331066-ediowz4s 100 28 2003 2003 CD cord-331066-ediowz4s 100 29 ( ( -LRB- cord-331066-ediowz4s 100 30 Balakirev Balakirev NNP cord-331066-ediowz4s 100 31 et et NNP cord-331066-ediowz4s 100 32 al al NNP cord-331066-ediowz4s 100 33 . . NNP cord-331066-ediowz4s 100 34 , , , cord-331066-ediowz4s 100 35 , , , cord-331066-ediowz4s 100 36 2005 2005 CD cord-331066-ediowz4s 101 1 ( ( -LRB- cord-331066-ediowz4s 101 2 Balakirev Balakirev NNP cord-331066-ediowz4s 101 3 et et NNP cord-331066-ediowz4s 101 4 al al NNP cord-331066-ediowz4s 101 5 . . . cord-331066-ediowz4s 102 1 , , , cord-331066-ediowz4s 102 2 , , , cord-331066-ediowz4s 102 3 2014 2014 CD cord-331066-ediowz4s 102 4 Chechetkin Chechetkin NNP cord-331066-ediowz4s 102 5 , , , cord-331066-ediowz4s 102 6 2011 2011 CD cord-331066-ediowz4s 102 7 ; ; : cord-331066-ediowz4s 103 1 Chechetkin Chechetkin NNP cord-331066-ediowz4s 103 2 & & CC cord-331066-ediowz4s 103 3 Lobzin Lobzin NNP cord-331066-ediowz4s 103 4 , , , cord-331066-ediowz4s 103 5 1996 1996 CD cord-331066-ediowz4s 103 6 ; ; : cord-331066-ediowz4s 103 7 Chechetkin Chechetkin NNP cord-331066-ediowz4s 103 8 & & CC cord-331066-ediowz4s 103 9 Turygin Turygin NNP cord-331066-ediowz4s 103 10 , , , cord-331066-ediowz4s 103 11 1994 1994 CD cord-331066-ediowz4s 103 12 ) ) -RRB- cord-331066-ediowz4s 103 13 . . . cord-331066-ediowz4s 104 1 The the DT cord-331066-ediowz4s 104 2 spectral spectral JJ cord-331066-ediowz4s 104 3 entropy entropy NN cord-331066-ediowz4s 104 4 is be VBZ cord-331066-ediowz4s 104 5 defined define VBN cord-331066-ediowz4s 104 6 as as IN cord-331066-ediowz4s 104 7 , , , cord-331066-ediowz4s 104 8 Its -PRON- PRP$ cord-331066-ediowz4s 104 9 mean mean JJ cord-331066-ediowz4s 104 10 value value NN cord-331066-ediowz4s 104 11 , , , cord-331066-ediowz4s 104 12 where where WRB cord-331066-ediowz4s 104 13 C C NNP cord-331066-ediowz4s 104 14 is be VBZ cord-331066-ediowz4s 104 15 Euler Euler NNP cord-331066-ediowz4s 104 16 constant constant NN cord-331066-ediowz4s 104 17 ; ; : cord-331066-ediowz4s 104 18 ð1ÀCÞ¼ ð1àcþ¼ CD cord-331066-ediowz4s 104 19 0.422785 0.422785 CD cord-331066-ediowz4s 104 20 … … NFP cord-331066-ediowz4s 104 21 , , , cord-331066-ediowz4s 104 22 attains attain VBZ cord-331066-ediowz4s 104 23 approximate approximate JJ cord-331066-ediowz4s 104 24 maximum maximum NN cord-331066-ediowz4s 104 25 for for IN cord-331066-ediowz4s 104 26 the the DT cord-331066-ediowz4s 104 27 random random JJ cord-331066-ediowz4s 104 28 sequences sequence NNS cord-331066-ediowz4s 104 29 . . . cord-331066-ediowz4s 105 1 The the DT cord-331066-ediowz4s 105 2 corresponding corresponding JJ cord-331066-ediowz4s 105 3 variance variance NN cord-331066-ediowz4s 105 4 for for IN cord-331066-ediowz4s 105 5 the the DT cord-331066-ediowz4s 105 6 spectral spectral JJ cord-331066-ediowz4s 105 7 entropy entropy NN cord-331066-ediowz4s 105 8 is be VBZ cord-331066-ediowz4s 105 9 given give VBN cord-331066-ediowz4s 105 10 by by IN cord-331066-ediowz4s 105 11 r r NN cord-331066-ediowz4s 105 12 2 2 CD cord-331066-ediowz4s 105 13 ðS ðs NN cord-331066-ediowz4s 105 14 a a DT cord-331066-ediowz4s 105 15 Þ þ NN cord-331066-ediowz4s 105 16 random random JJ cord-331066-ediowz4s 105 17 ¼ ¼ CD cord-331066-ediowz4s 105 18 0:289868 0:289868 CD cord-331066-ediowz4s 106 1 : : : cord-331066-ediowz4s 106 2 : : : cord-331066-ediowz4s 106 3 : : : cord-331066-ediowz4s 106 4 N n CD cord-331066-ediowz4s 106 5 : : : cord-331066-ediowz4s 106 6 The the DT cord-331066-ediowz4s 106 7 abundance abundance NN cord-331066-ediowz4s 106 8 of of IN cord-331066-ediowz4s 106 9 quasi quasi JJ cord-331066-ediowz4s 106 10 - - JJ cord-331066-ediowz4s 106 11 periodic periodic JJ cord-331066-ediowz4s 106 12 patterns pattern NNS cord-331066-ediowz4s 106 13 in in IN cord-331066-ediowz4s 106 14 the the DT cord-331066-ediowz4s 106 15 genomes genome NNS cord-331066-ediowz4s 106 16 of of IN cord-331066-ediowz4s 106 17 different different JJ cord-331066-ediowz4s 106 18 lengths length NNS cord-331066-ediowz4s 106 19 can can MD cord-331066-ediowz4s 106 20 be be VB cord-331066-ediowz4s 106 21 assessed assess VBN cord-331066-ediowz4s 106 22 by by IN cord-331066-ediowz4s 106 23 the the DT cord-331066-ediowz4s 106 24 relative relative JJ cord-331066-ediowz4s 106 25 spectral spectral JJ cord-331066-ediowz4s 106 26 entropies entropy NNS cord-331066-ediowz4s 106 27 , , , cord-331066-ediowz4s 106 28 The the DT cord-331066-ediowz4s 106 29 relative relative JJ cord-331066-ediowz4s 106 30 spectral spectral JJ cord-331066-ediowz4s 106 31 entropy entropy NN cord-331066-ediowz4s 106 32 serves serve VBZ cord-331066-ediowz4s 106 33 also also RB cord-331066-ediowz4s 106 34 for for IN cord-331066-ediowz4s 106 35 the the DT cord-331066-ediowz4s 106 36 assessment assessment NN cord-331066-ediowz4s 106 37 of of IN cord-331066-ediowz4s 106 38 the the DT cord-331066-ediowz4s 106 39 load load NN cord-331066-ediowz4s 106 40 from from IN cord-331066-ediowz4s 106 41 point point NN cord-331066-ediowz4s 106 42 mutations mutation NNS cord-331066-ediowz4s 106 43 and and CC cord-331066-ediowz4s 106 44 indels indel NNS cord-331066-ediowz4s 106 45 on on IN cord-331066-ediowz4s 106 46 the the DT cord-331066-ediowz4s 106 47 genomes genome NNS cord-331066-ediowz4s 106 48 or or CC cord-331066-ediowz4s 106 49 on on IN cord-331066-ediowz4s 106 50 the the DT cord-331066-ediowz4s 106 51 particular particular JJ cord-331066-ediowz4s 106 52 genes gene NNS cord-331066-ediowz4s 106 53 and and CC cord-331066-ediowz4s 106 54 pseudogenes pseudogene NNS cord-331066-ediowz4s 106 55 ( ( -LRB- cord-331066-ediowz4s 106 56 Balakirev Balakirev NNP cord-331066-ediowz4s 106 57 et et FW cord-331066-ediowz4s 106 58 al al NNP cord-331066-ediowz4s 106 59 . . . cord-331066-ediowz4s 107 1 , , , cord-331066-ediowz4s 107 2 2003 2003 CD cord-331066-ediowz4s 107 3 ( ( -LRB- cord-331066-ediowz4s 107 4 Balakirev Balakirev NNP cord-331066-ediowz4s 107 5 et et NNP cord-331066-ediowz4s 107 6 al al NNP cord-331066-ediowz4s 107 7 . . . cord-331066-ediowz4s 108 1 , , , cord-331066-ediowz4s 108 2 , , , cord-331066-ediowz4s 108 3 2005 2005 CD cord-331066-ediowz4s 109 1 ( ( -LRB- cord-331066-ediowz4s 109 2 Balakirev Balakirev NNP cord-331066-ediowz4s 109 3 et et NNP cord-331066-ediowz4s 109 4 al al NNP cord-331066-ediowz4s 109 5 . . . cord-331066-ediowz4s 110 1 , , , cord-331066-ediowz4s 110 2 , , , cord-331066-ediowz4s 110 3 2014 2014 CD cord-331066-ediowz4s 110 4 . . . cord-331066-ediowz4s 111 1 Early early JJ cord-331066-ediowz4s 111 2 studies study NNS cord-331066-ediowz4s 111 3 based base VBN cord-331066-ediowz4s 111 4 on on IN cord-331066-ediowz4s 111 5 electron electron NN cord-331066-ediowz4s 111 6 microscopy microscopy NNS cord-331066-ediowz4s 111 7 have have VBP cord-331066-ediowz4s 111 8 revealed reveal VBN cord-331066-ediowz4s 111 9 that that IN cord-331066-ediowz4s 111 10 the the DT cord-331066-ediowz4s 111 11 ribonucleocapsid ribonucleocapsid NNP cord-331066-ediowz4s 111 12 of of IN cord-331066-ediowz4s 111 13 coronaviruses coronaviruse NNS cord-331066-ediowz4s 111 14 is be VBZ cord-331066-ediowz4s 111 15 helical helical JJ cord-331066-ediowz4s 111 16 , , , cord-331066-ediowz4s 111 17 consisting consist VBG cord-331066-ediowz4s 111 18 of of IN cord-331066-ediowz4s 111 19 coils coil NNS cord-331066-ediowz4s 111 20 of of IN cord-331066-ediowz4s 111 21 9 9 CD cord-331066-ediowz4s 111 22 - - SYM cord-331066-ediowz4s 111 23 16 16 CD cord-331066-ediowz4s 111 24 nm nm NN cord-331066-ediowz4s 111 25 in in IN cord-331066-ediowz4s 111 26 diameter diameter NN cord-331066-ediowz4s 111 27 and and CC cord-331066-ediowz4s 111 28 a a DT cord-331066-ediowz4s 111 29 hollow hollow JJ cord-331066-ediowz4s 111 30 interior interior NN cord-331066-ediowz4s 111 31 of of IN cord-331066-ediowz4s 111 32 approximately approximately RB cord-331066-ediowz4s 111 33 3 3 CD cord-331066-ediowz4s 111 34 - - SYM cord-331066-ediowz4s 111 35 4 4 CD cord-331066-ediowz4s 111 36 nm nm NN cord-331066-ediowz4s 112 1 ( ( -LRB- cord-331066-ediowz4s 112 2 Macneughton Macneughton NNP cord-331066-ediowz4s 112 3 et et FW cord-331066-ediowz4s 112 4 al al NNP cord-331066-ediowz4s 112 5 . . NNP cord-331066-ediowz4s 112 6 , , , cord-331066-ediowz4s 112 7 1978 1978 CD cord-331066-ediowz4s 112 8 ) ) -RRB- cord-331066-ediowz4s 112 9 . . . cord-331066-ediowz4s 113 1 Chang Chang NNP cord-331066-ediowz4s 113 2 et et NNP cord-331066-ediowz4s 113 3 al al NNP cord-331066-ediowz4s 113 4 . . . cord-331066-ediowz4s 114 1 ( ( -LRB- cord-331066-ediowz4s 114 2 2014 2014 CD cord-331066-ediowz4s 114 3 ) ) -RRB- cord-331066-ediowz4s 114 4 asserted assert VBD cord-331066-ediowz4s 114 5 that that IN cord-331066-ediowz4s 114 6 for for IN cord-331066-ediowz4s 114 7 the the DT cord-331066-ediowz4s 114 8 SARS SARS NNP cord-331066-ediowz4s 114 9 - - HYPH cord-331066-ediowz4s 114 10 CoV CoV NNP cord-331066-ediowz4s 114 11 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 114 12 an an DT cord-331066-ediowz4s 114 13 outer outer JJ cord-331066-ediowz4s 114 14 diameter diameter NN cord-331066-ediowz4s 114 15 of of IN cord-331066-ediowz4s 114 16 16 16 CD cord-331066-ediowz4s 114 17 nm nm NN cord-331066-ediowz4s 114 18 and and CC cord-331066-ediowz4s 114 19 an an DT cord-331066-ediowz4s 114 20 inner inner JJ cord-331066-ediowz4s 114 21 diameter diameter NN cord-331066-ediowz4s 114 22 of of IN cord-331066-ediowz4s 114 23 4 4 CD cord-331066-ediowz4s 114 24 nm nm NNS cord-331066-ediowz4s 114 25 are be VBP cord-331066-ediowz4s 114 26 consistent consistent JJ cord-331066-ediowz4s 114 27 with with IN cord-331066-ediowz4s 114 28 cryo cryo NN cord-331066-ediowz4s 114 29 - - HYPH cord-331066-ediowz4s 114 30 EM EM NNP cord-331066-ediowz4s 114 31 observations observation NNS cord-331066-ediowz4s 114 32 . . . cord-331066-ediowz4s 115 1 The the DT cord-331066-ediowz4s 115 2 length length NN cord-331066-ediowz4s 115 3 of of IN cord-331066-ediowz4s 115 4 a a DT cord-331066-ediowz4s 115 5 helical helical JJ cord-331066-ediowz4s 115 6 turn turn NN cord-331066-ediowz4s 115 7 per per IN cord-331066-ediowz4s 115 8 pitch pitch NN cord-331066-ediowz4s 115 9 is be VBZ cord-331066-ediowz4s 115 10 where where WRB cord-331066-ediowz4s 115 11 d d NNP cord-331066-ediowz4s 115 12 is be VBZ cord-331066-ediowz4s 115 13 the the DT cord-331066-ediowz4s 115 14 diameter diameter NN cord-331066-ediowz4s 115 15 of of IN cord-331066-ediowz4s 115 16 the the DT cord-331066-ediowz4s 115 17 helix helix NN cord-331066-ediowz4s 115 18 and and CC cord-331066-ediowz4s 115 19 h h NN cord-331066-ediowz4s 115 20 is be VBZ cord-331066-ediowz4s 115 21 the the DT cord-331066-ediowz4s 115 22 pitch pitch NN cord-331066-ediowz4s 115 23 . . . cord-331066-ediowz4s 116 1 According accord VBG cord-331066-ediowz4s 116 2 to to IN cord-331066-ediowz4s 116 3 Chen Chen NNP cord-331066-ediowz4s 116 4 et et NNP cord-331066-ediowz4s 116 5 al al NNP cord-331066-ediowz4s 116 6 . . . cord-331066-ediowz4s 117 1 ( ( -LRB- cord-331066-ediowz4s 117 2 2007 2007 CD cord-331066-ediowz4s 117 3 ) ) -RRB- cord-331066-ediowz4s 117 4 , , , cord-331066-ediowz4s 117 5 the the DT cord-331066-ediowz4s 117 6 pitch pitch NN cord-331066-ediowz4s 117 7 for for IN cord-331066-ediowz4s 117 8 the the DT cord-331066-ediowz4s 117 9 SARS SARS NNP cord-331066-ediowz4s 117 10 - - HYPH cord-331066-ediowz4s 117 11 CoV CoV NNP cord-331066-ediowz4s 117 12 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 117 13 is be VBZ cord-331066-ediowz4s 117 14 h h NNP cord-331066-ediowz4s 117 15 ¼ ¼ CD cord-331066-ediowz4s 117 16 14 14 CD cord-331066-ediowz4s 117 17 nm nm NN cord-331066-ediowz4s 117 18 . . . cord-331066-ediowz4s 118 1 Taking take VBG cord-331066-ediowz4s 118 2 the the DT cord-331066-ediowz4s 118 3 distance distance NN cord-331066-ediowz4s 118 4 between between IN cord-331066-ediowz4s 118 5 RNA RNA NNP cord-331066-ediowz4s 118 6 bases basis NNS cord-331066-ediowz4s 118 7 as as IN cord-331066-ediowz4s 118 8 0.34 0.34 CD cord-331066-ediowz4s 118 9 nm nm NN cord-331066-ediowz4s 118 10 , , , cord-331066-ediowz4s 118 11 the the DT cord-331066-ediowz4s 118 12 positioning positioning NN cord-331066-ediowz4s 118 13 of of IN cord-331066-ediowz4s 118 14 RNA RNA NNP cord-331066-ediowz4s 118 15 near near IN cord-331066-ediowz4s 118 16 the the DT cord-331066-ediowz4s 118 17 inner inner JJ cord-331066-ediowz4s 118 18 diameter diameter NN cord-331066-ediowz4s 118 19 of of IN cord-331066-ediowz4s 118 20 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 118 21 provides provide VBZ cord-331066-ediowz4s 118 22 the the DT cord-331066-ediowz4s 118 23 length length NN cord-331066-ediowz4s 118 24 of of IN cord-331066-ediowz4s 118 25 RNA RNA NNP cord-331066-ediowz4s 118 26 turn turn VB cord-331066-ediowz4s 118 27 about about RB cord-331066-ediowz4s 118 28 54 54 CD cord-331066-ediowz4s 118 29 - - SYM cord-331066-ediowz4s 118 30 56 56 CD cord-331066-ediowz4s 118 31 nt nt RB cord-331066-ediowz4s 118 32 , , , cord-331066-ediowz4s 118 33 the the DT cord-331066-ediowz4s 118 34 positioning positioning NN cord-331066-ediowz4s 118 35 of of IN cord-331066-ediowz4s 118 36 RNA RNA NNP cord-331066-ediowz4s 118 37 in in IN cord-331066-ediowz4s 118 38 the the DT cord-331066-ediowz4s 118 39 middle middle NN cord-331066-ediowz4s 118 40 between between IN cord-331066-ediowz4s 118 41 the the DT cord-331066-ediowz4s 118 42 inner inner JJ cord-331066-ediowz4s 118 43 and and CC cord-331066-ediowz4s 118 44 outer outer JJ cord-331066-ediowz4s 118 45 diameters diameter NNS cord-331066-ediowz4s 118 46 would would MD cord-331066-ediowz4s 118 47 provide provide VB cord-331066-ediowz4s 118 48 the the DT cord-331066-ediowz4s 118 49 length length NN cord-331066-ediowz4s 118 50 of of IN cord-331066-ediowz4s 118 51 turn turn NN cord-331066-ediowz4s 118 52 about about RB cord-331066-ediowz4s 118 53 84 84 CD cord-331066-ediowz4s 118 54 - - SYM cord-331066-ediowz4s 118 55 87 87 CD cord-331066-ediowz4s 118 56 nt nt RB cord-331066-ediowz4s 118 57 , , , cord-331066-ediowz4s 118 58 whereas whereas IN cord-331066-ediowz4s 118 59 the the DT cord-331066-ediowz4s 118 60 positioning positioning NN cord-331066-ediowz4s 118 61 of of IN cord-331066-ediowz4s 118 62 RNA RNA NNP cord-331066-ediowz4s 118 63 at at IN cord-331066-ediowz4s 118 64 the the DT cord-331066-ediowz4s 118 65 outer outer JJ cord-331066-ediowz4s 118 66 diameter diameter NN cord-331066-ediowz4s 118 67 would would MD cord-331066-ediowz4s 118 68 provide provide VB cord-331066-ediowz4s 118 69 the the DT cord-331066-ediowz4s 118 70 length length NN cord-331066-ediowz4s 118 71 of of IN cord-331066-ediowz4s 118 72 turn turn NN cord-331066-ediowz4s 118 73 about about RB cord-331066-ediowz4s 118 74 153 153 CD cord-331066-ediowz4s 118 75 - - SYM cord-331066-ediowz4s 118 76 154 154 CD cord-331066-ediowz4s 118 77 nt nt RB cord-331066-ediowz4s 118 78 . . . cord-331066-ediowz4s 119 1 Chang Chang NNP cord-331066-ediowz4s 119 2 et et NNP cord-331066-ediowz4s 119 3 al al NNP cord-331066-ediowz4s 119 4 . . . cord-331066-ediowz4s 120 1 ( ( -LRB- cord-331066-ediowz4s 120 2 2009 2009 CD cord-331066-ediowz4s 120 3 ) ) -RRB- cord-331066-ediowz4s 120 4 found find VBD cord-331066-ediowz4s 120 5 multiple multiple JJ cord-331066-ediowz4s 120 6 ( ( -LRB- cord-331066-ediowz4s 120 7 at at RB cord-331066-ediowz4s 120 8 least least RBS cord-331066-ediowz4s 120 9 three three CD cord-331066-ediowz4s 120 10 ) ) -RRB- cord-331066-ediowz4s 120 11 nucleic nucleic JJ cord-331066-ediowz4s 120 12 acid acid NN cord-331066-ediowz4s 120 13 binding bind VBG cord-331066-ediowz4s 120 14 sites site NNS cord-331066-ediowz4s 120 15 in in IN cord-331066-ediowz4s 120 16 N n CD cord-331066-ediowz4s 120 17 proteins protein NNS cord-331066-ediowz4s 120 18 . . . cord-331066-ediowz4s 121 1 Therefore therefore RB cord-331066-ediowz4s 121 2 , , , cord-331066-ediowz4s 121 3 the the DT cord-331066-ediowz4s 121 4 intermediate intermediate JJ cord-331066-ediowz4s 121 5 dynamic dynamic JJ cord-331066-ediowz4s 121 6 positioning positioning NN cord-331066-ediowz4s 121 7 of of IN cord-331066-ediowz4s 121 8 RNA RNA NNP cord-331066-ediowz4s 121 9 in in IN cord-331066-ediowz4s 121 10 the the DT cord-331066-ediowz4s 121 11 middle middle NN cord-331066-ediowz4s 121 12 during during IN cord-331066-ediowz4s 121 13 assembly assembly NN cord-331066-ediowz4s 121 14 / / SYM cord-331066-ediowz4s 121 15 packaging packaging NN cord-331066-ediowz4s 121 16 can can MD cord-331066-ediowz4s 121 17 not not RB cord-331066-ediowz4s 121 18 be be VB cord-331066-ediowz4s 121 19 excluded exclude VBN cord-331066-ediowz4s 121 20 . . . cord-331066-ediowz4s 122 1 At at IN cord-331066-ediowz4s 122 2 the the DT cord-331066-ediowz4s 122 3 final final JJ cord-331066-ediowz4s 122 4 stage stage NN cord-331066-ediowz4s 122 5 of of IN cord-331066-ediowz4s 122 6 packaging packaging NN cord-331066-ediowz4s 122 7 , , , cord-331066-ediowz4s 122 8 ssRNA ssRNA VBG cord-331066-ediowz4s 122 9 is be VBZ cord-331066-ediowz4s 122 10 assumed assume VBN cord-331066-ediowz4s 122 11 to to TO cord-331066-ediowz4s 122 12 be be VB cord-331066-ediowz4s 122 13 positioned position VBN cord-331066-ediowz4s 122 14 at at IN cord-331066-ediowz4s 122 15 the the DT cord-331066-ediowz4s 122 16 inner inner JJ cord-331066-ediowz4s 122 17 diameter diameter NN cord-331066-ediowz4s 122 18 of of IN cord-331066-ediowz4s 122 19 the the DT cord-331066-ediowz4s 122 20 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 122 21 in in IN cord-331066-ediowz4s 122 22 accordance accordance NN cord-331066-ediowz4s 122 23 with with IN cord-331066-ediowz4s 122 24 cryo cryo NN cord-331066-ediowz4s 122 25 - - HYPH cord-331066-ediowz4s 122 26 EM em NN cord-331066-ediowz4s 122 27 observations observation NNS cord-331066-ediowz4s 122 28 ( ( -LRB- cord-331066-ediowz4s 122 29 Chang Chang NNP cord-331066-ediowz4s 122 30 et et NNP cord-331066-ediowz4s 122 31 al al NNP cord-331066-ediowz4s 122 32 . . NNP cord-331066-ediowz4s 122 33 , , , cord-331066-ediowz4s 122 34 2014 2014 CD cord-331066-ediowz4s 122 35 ) ) -RRB- cord-331066-ediowz4s 122 36 . . . cord-331066-ediowz4s 123 1 We -PRON- PRP cord-331066-ediowz4s 123 2 performed perform VBD cord-331066-ediowz4s 123 3 the the DT cord-331066-ediowz4s 123 4 complete complete JJ cord-331066-ediowz4s 123 5 combined combine VBN cord-331066-ediowz4s 123 6 analysis analysis NN cord-331066-ediowz4s 123 7 of of IN cord-331066-ediowz4s 123 8 the the DT cord-331066-ediowz4s 123 9 SARS SARS NNP cord-331066-ediowz4s 123 10 - - HYPH cord-331066-ediowz4s 123 11 CoV CoV NNP cord-331066-ediowz4s 123 12 and and CC cord-331066-ediowz4s 123 13 SARS SARS NNP cord-331066-ediowz4s 123 14 - - HYPH cord-331066-ediowz4s 123 15 CoV-2 CoV-2 NNP cord-331066-ediowz4s 123 16 genomes genome NNS cord-331066-ediowz4s 123 17 based base VBN cord-331066-ediowz4s 123 18 on on IN cord-331066-ediowz4s 123 19 DFT DFT NNP cord-331066-ediowz4s 123 20 , , , cord-331066-ediowz4s 123 21 DDFT DDFT NNP cord-331066-ediowz4s 123 22 , , , cord-331066-ediowz4s 123 23 NCF NCF NNP cord-331066-ediowz4s 123 24 and and CC cord-331066-ediowz4s 123 25 pattern pattern NN cord-331066-ediowz4s 123 26 correlation correlation NN cord-331066-ediowz4s 123 27 functions function NNS cord-331066-ediowz4s 123 28 ( ( -LRB- cord-331066-ediowz4s 123 29 Chechetkin Chechetkin NNP cord-331066-ediowz4s 123 30 & & CC cord-331066-ediowz4s 123 31 Lobzin Lobzin NNP cord-331066-ediowz4s 123 32 , , , cord-331066-ediowz4s 123 33 2020b 2020b CD cord-331066-ediowz4s 123 34 ) ) -RRB- cord-331066-ediowz4s 123 35 and and CC cord-331066-ediowz4s 123 36 screened screen VBD cord-331066-ediowz4s 123 37 all all DT cord-331066-ediowz4s 123 38 range range NN cord-331066-ediowz4s 123 39 of of IN cord-331066-ediowz4s 123 40 putative putative JJ cord-331066-ediowz4s 123 41 periods period NNS cord-331066-ediowz4s 123 42 from from IN cord-331066-ediowz4s 123 43 the the DT cord-331066-ediowz4s 123 44 shortest short JJS cord-331066-ediowz4s 123 45 period period NN cord-331066-ediowz4s 123 46 of of IN cord-331066-ediowz4s 123 47 2 2 CD cord-331066-ediowz4s 123 48 nt nt RB cord-331066-ediowz4s 123 49 to to IN cord-331066-ediowz4s 123 50 the the DT cord-331066-ediowz4s 123 51 large large JJ cord-331066-ediowz4s 123 52 - - HYPH cord-331066-ediowz4s 123 53 scale scale NN cord-331066-ediowz4s 123 54 periods period NNS cord-331066-ediowz4s 123 55 comparable comparable JJ cord-331066-ediowz4s 123 56 to to IN cord-331066-ediowz4s 123 57 the the DT cord-331066-ediowz4s 123 58 whole whole JJ cord-331066-ediowz4s 123 59 genome genome NN cord-331066-ediowz4s 123 60 lengths length NNS cord-331066-ediowz4s 123 61 . . . cord-331066-ediowz4s 124 1 The the DT cord-331066-ediowz4s 124 2 most most RBS cord-331066-ediowz4s 124 3 interesting interesting JJ cord-331066-ediowz4s 124 4 results result NNS cord-331066-ediowz4s 124 5 related relate VBN cord-331066-ediowz4s 124 6 to to IN cord-331066-ediowz4s 124 7 the the DT cord-331066-ediowz4s 124 8 ribonucleocapsid ribonucleocapsid NNP cord-331066-ediowz4s 124 9 assembly/ assembly/ CD cord-331066-ediowz4s 124 10 packaging packaging NN cord-331066-ediowz4s 124 11 are be VBP cord-331066-ediowz4s 124 12 presented present VBN cord-331066-ediowz4s 124 13 below below RB cord-331066-ediowz4s 124 14 . . . cord-331066-ediowz4s 125 1 We -PRON- PRP cord-331066-ediowz4s 125 2 took take VBD cord-331066-ediowz4s 125 3 for for IN cord-331066-ediowz4s 125 4 analysis analysis NN cord-331066-ediowz4s 125 5 one one CD cord-331066-ediowz4s 125 6 genomic genomic JJ cord-331066-ediowz4s 125 7 sequence sequence NN cord-331066-ediowz4s 125 8 for for IN cord-331066-ediowz4s 125 9 SARS SARS NNP cord-331066-ediowz4s 125 10 - - HYPH cord-331066-ediowz4s 125 11 CoV CoV NNP cord-331066-ediowz4s 125 12 ( ( -LRB- cord-331066-ediowz4s 125 13 GenBank GenBank NNP cord-331066-ediowz4s 125 14 accession accession NN cord-331066-ediowz4s 125 15 : : : cord-331066-ediowz4s 125 16 NC_004718 nc_004718 NN cord-331066-ediowz4s 125 17 ; ; : cord-331066-ediowz4s 125 18 M M NNP cord-331066-ediowz4s 125 19 ¼ ¼ CD cord-331066-ediowz4s 125 20 29,751 29,751 CD cord-331066-ediowz4s 125 21 ; ; : cord-331066-ediowz4s 125 22 N n CD cord-331066-ediowz4s 125 23 A A NNP cord-331066-ediowz4s 125 24 ¼ ¼ CD cord-331066-ediowz4s 125 25 8481 8481 CD cord-331066-ediowz4s 125 26 , , , cord-331066-ediowz4s 125 27 N n CD cord-331066-ediowz4s 125 28 G g NN cord-331066-ediowz4s 125 29 ¼ ¼ CD cord-331066-ediowz4s 125 30 6187 6187 CD cord-331066-ediowz4s 125 31 , , , cord-331066-ediowz4s 125 32 N N NNP cord-331066-ediowz4s 125 33 T T NNP cord-331066-ediowz4s 125 34 ¼ ¼ CD cord-331066-ediowz4s 125 35 9143 9143 CD cord-331066-ediowz4s 125 36 , , , cord-331066-ediowz4s 125 37 N N NNP cord-331066-ediowz4s 125 38 C C NNP cord-331066-ediowz4s 125 39 ¼ ¼ CD cord-331066-ediowz4s 125 40 5940 5940 CD cord-331066-ediowz4s 125 41 ) ) -RRB- cord-331066-ediowz4s 125 42 as as IN cord-331066-ediowz4s 125 43 a a DT cord-331066-ediowz4s 125 44 reference reference NN cord-331066-ediowz4s 125 45 and and CC cord-331066-ediowz4s 125 46 the the DT cord-331066-ediowz4s 125 47 genomic genomic JJ cord-331066-ediowz4s 125 48 sequences sequence NNS cord-331066-ediowz4s 125 49 for for IN cord-331066-ediowz4s 125 50 three three CD cord-331066-ediowz4s 125 51 isolates isolate NNS cord-331066-ediowz4s 125 52 of of IN cord-331066-ediowz4s 125 53 SARS SARS NNP cord-331066-ediowz4s 125 54 - - HYPH cord-331066-ediowz4s 125 55 CoV-2 CoV-2 NNP cord-331066-ediowz4s 125 56 ( ( -LRB- cord-331066-ediowz4s 125 57 GenBank GenBank NNP cord-331066-ediowz4s 125 58 accessions accession NNS cord-331066-ediowz4s 125 59 : : : cord-331066-ediowz4s 125 60 to to TO cord-331066-ediowz4s 125 61 assess assess VB cord-331066-ediowz4s 125 62 the the DT cord-331066-ediowz4s 125 63 impact impact NN cord-331066-ediowz4s 125 64 of of IN cord-331066-ediowz4s 125 65 point point NN cord-331066-ediowz4s 125 66 mutations mutation NNS cord-331066-ediowz4s 125 67 and and CC cord-331066-ediowz4s 125 68 indels indel NNS cord-331066-ediowz4s 125 69 on on IN cord-331066-ediowz4s 125 70 the the DT cord-331066-ediowz4s 125 71 detected detect VBN cord-331066-ediowz4s 125 72 patterns pattern NNS cord-331066-ediowz4s 125 73 . . . cord-331066-ediowz4s 126 1 Henceforth henceforth RB cord-331066-ediowz4s 126 2 , , , cord-331066-ediowz4s 126 3 the the DT cord-331066-ediowz4s 126 4 viruses virus NNS cord-331066-ediowz4s 126 5 will will MD cord-331066-ediowz4s 126 6 be be VB cord-331066-ediowz4s 126 7 denoted denote VBN cord-331066-ediowz4s 126 8 by by IN cord-331066-ediowz4s 126 9 their -PRON- PRP$ cord-331066-ediowz4s 126 10 accessions accession NNS cord-331066-ediowz4s 126 11 . . . cord-331066-ediowz4s 127 1 Taking take VBG cord-331066-ediowz4s 127 2 into into IN cord-331066-ediowz4s 127 3 account account NN cord-331066-ediowz4s 127 4 the the DT cord-331066-ediowz4s 127 5 transitional transitional JJ cord-331066-ediowz4s 127 6 invariance invariance NN cord-331066-ediowz4s 127 7 of of IN cord-331066-ediowz4s 127 8 a a DT cord-331066-ediowz4s 127 9 helix helix NN cord-331066-ediowz4s 127 10 , , , cord-331066-ediowz4s 127 11 the the DT cord-331066-ediowz4s 127 12 main main JJ cord-331066-ediowz4s 127 13 results result NNS cord-331066-ediowz4s 127 14 will will MD cord-331066-ediowz4s 127 15 be be VB cord-331066-ediowz4s 127 16 given give VBN cord-331066-ediowz4s 127 17 for for IN cord-331066-ediowz4s 127 18 NCF NCF NNP cord-331066-ediowz4s 127 19 . . . cord-331066-ediowz4s 128 1 The the DT cord-331066-ediowz4s 128 2 presence presence NN cord-331066-ediowz4s 128 3 of of IN cord-331066-ediowz4s 128 4 periodic periodic JJ cord-331066-ediowz4s 128 5 components component NNS cord-331066-ediowz4s 128 6 in in IN cord-331066-ediowz4s 128 7 NCF NCF NNP cord-331066-ediowz4s 128 8 was be VBD cord-331066-ediowz4s 128 9 proved prove VBN cord-331066-ediowz4s 128 10 by by IN cord-331066-ediowz4s 128 11 combining combine VBG cord-331066-ediowz4s 128 12 DFT DFT NNP cord-331066-ediowz4s 128 13 and and CC cord-331066-ediowz4s 128 14 DDFT DDFT NNP cord-331066-ediowz4s 128 15 . . . cord-331066-ediowz4s 129 1 The the DT cord-331066-ediowz4s 129 2 general general JJ cord-331066-ediowz4s 129 3 overviews overview NNS cord-331066-ediowz4s 129 4 of of IN cord-331066-ediowz4s 129 5 the the DT cord-331066-ediowz4s 129 6 plots plot NNS cord-331066-ediowz4s 129 7 for for IN cord-331066-ediowz4s 129 8 the the DT cord-331066-ediowz4s 129 9 normalized normalized JJ cord-331066-ediowz4s 129 10 NCF NCF NNP cord-331066-ediowz4s 129 11 deviations deviation NNS cord-331066-ediowz4s 129 12 defined define VBN cord-331066-ediowz4s 129 13 by by IN cord-331066-ediowz4s 129 14 Equation equation NN cord-331066-ediowz4s 129 15 ( ( -LRB- cord-331066-ediowz4s 129 16 20 20 CD cord-331066-ediowz4s 129 17 ) ) -RRB- cord-331066-ediowz4s 129 18 are be VBP cord-331066-ediowz4s 129 19 shown show VBN cord-331066-ediowz4s 129 20 in in IN cord-331066-ediowz4s 129 21 Figures figure NNS cord-331066-ediowz4s 129 22 1 1 CD cord-331066-ediowz4s 129 23 and and CC cord-331066-ediowz4s 129 24 2 2 CD cord-331066-ediowz4s 129 25 . . . cord-331066-ediowz4s 130 1 The the DT cord-331066-ediowz4s 130 2 overview overview NN cord-331066-ediowz4s 130 3 for for IN cord-331066-ediowz4s 130 4 MT371038 MT371038 NNP cord-331066-ediowz4s 130 5 is be VBZ cord-331066-ediowz4s 130 6 closer close JJR cord-331066-ediowz4s 130 7 to to IN cord-331066-ediowz4s 130 8 that that DT cord-331066-ediowz4s 130 9 shown show VBN cord-331066-ediowz4s 130 10 in in IN cord-331066-ediowz4s 130 11 Figure figure NN cord-331066-ediowz4s 130 12 1 1 CD cord-331066-ediowz4s 130 13 , , , cord-331066-ediowz4s 130 14 while while IN cord-331066-ediowz4s 130 15 the the DT cord-331066-ediowz4s 130 16 corresponding correspond VBG cord-331066-ediowz4s 130 17 plots plot NNS cord-331066-ediowz4s 130 18 for for IN cord-331066-ediowz4s 130 19 MT295464 MT295464 NNP cord-331066-ediowz4s 130 20 are be VBP cord-331066-ediowz4s 130 21 similar similar JJ cord-331066-ediowz4s 130 22 to to IN cord-331066-ediowz4s 130 23 those those DT cord-331066-ediowz4s 130 24 shown show VBN cord-331066-ediowz4s 130 25 in in IN cord-331066-ediowz4s 130 26 Figure figure NN cord-331066-ediowz4s 130 27 2 2 CD cord-331066-ediowz4s 130 28 . . . cord-331066-ediowz4s 131 1 Then then RB cord-331066-ediowz4s 131 2 , , , cord-331066-ediowz4s 131 3 all all DT cord-331066-ediowz4s 131 4 plots plot NNS cord-331066-ediowz4s 131 5 for for IN cord-331066-ediowz4s 131 6 NCF NCF NNP cord-331066-ediowz4s 131 7 were be VBD cord-331066-ediowz4s 131 8 recalculated recalculate VBN cord-331066-ediowz4s 131 9 using use VBG cord-331066-ediowz4s 131 10 Equations Equations NNPS cord-331066-ediowz4s 131 11 ( ( -LRB- cord-331066-ediowz4s 131 12 26 26 CD cord-331066-ediowz4s 131 13 ) ) -RRB- cord-331066-ediowz4s 131 14 and and CC cord-331066-ediowz4s 131 15 ( ( -LRB- cord-331066-ediowz4s 131 16 27 27 CD cord-331066-ediowz4s 131 17 ) ) -RRB- cord-331066-ediowz4s 131 18 and and CC cord-331066-ediowz4s 131 19 replacing replace VBG cord-331066-ediowz4s 131 20 all all DT cord-331066-ediowz4s 131 21 highest high JJS cord-331066-ediowz4s 131 22 harmonics harmonic NNS cord-331066-ediowz4s 131 23 in in IN cord-331066-ediowz4s 131 24 the the DT cord-331066-ediowz4s 131 25 DFT dft NN cord-331066-ediowz4s 131 26 spectra spectra NN cord-331066-ediowz4s 131 27 by by IN cord-331066-ediowz4s 131 28 the the DT cord-331066-ediowz4s 131 29 peaks peak NNS cord-331066-ediowz4s 131 30 assessed assess VBN cord-331066-ediowz4s 131 31 by by IN cord-331066-ediowz4s 131 32 extreme extreme JJ cord-331066-ediowz4s 131 33 value value NN cord-331066-ediowz4s 131 34 statistics statistic NNS cord-331066-ediowz4s 131 35 ( ( -LRB- cord-331066-ediowz4s 131 36 cf cf NN cord-331066-ediowz4s 131 37 . . . cord-331066-ediowz4s 132 1 Chechetkin Chechetkin NNP cord-331066-ediowz4s 132 2 & & CC cord-331066-ediowz4s 132 3 Lobzin Lobzin NNP cord-331066-ediowz4s 132 4 , , , cord-331066-ediowz4s 132 5 2019 2019 CD cord-331066-ediowz4s 132 6 ) ) -RRB- cord-331066-ediowz4s 132 7 . . . cord-331066-ediowz4s 133 1 The the DT cord-331066-ediowz4s 133 2 initial initial JJ cord-331066-ediowz4s 133 3 ranges range NNS cord-331066-ediowz4s 133 4 of of IN cord-331066-ediowz4s 133 5 the the DT cord-331066-ediowz4s 133 6 recalculated recalculate VBN cord-331066-ediowz4s 133 7 plots plot NNS cord-331066-ediowz4s 133 8 are be VBP cord-331066-ediowz4s 133 9 shown show VBN cord-331066-ediowz4s 133 10 in in IN cord-331066-ediowz4s 133 11 the the DT cord-331066-ediowz4s 133 12 inserts insert NNS cord-331066-ediowz4s 133 13 to to IN cord-331066-ediowz4s 133 14 Figures figure NNS cord-331066-ediowz4s 133 15 1 1 CD cord-331066-ediowz4s 133 16 and and CC cord-331066-ediowz4s 133 17 2 2 CD cord-331066-ediowz4s 133 18 . . . cord-331066-ediowz4s 134 1 The the DT cord-331066-ediowz4s 134 2 deviations deviation NNS cord-331066-ediowz4s 134 3 corresponding correspond VBG cord-331066-ediowz4s 134 4 to to IN cord-331066-ediowz4s 134 5 the the DT cord-331066-ediowz4s 134 6 most most RBS cord-331066-ediowz4s 134 7 pronounced pronounce VBN cord-331066-ediowz4s 134 8 patterns pattern NNS cord-331066-ediowz4s 134 9 are be VBP cord-331066-ediowz4s 134 10 shown show VBN cord-331066-ediowz4s 134 11 explicitly explicitly RB cord-331066-ediowz4s 134 12 by by IN cord-331066-ediowz4s 134 13 arrows arrow NNS cord-331066-ediowz4s 134 14 . . . cord-331066-ediowz4s 135 1 Such such JJ cord-331066-ediowz4s 135 2 patterns pattern NNS cord-331066-ediowz4s 135 3 are be VBP cord-331066-ediowz4s 135 4 quasi quasi JJ cord-331066-ediowz4s 135 5 - - JJ cord-331066-ediowz4s 135 6 periodic periodic JJ cord-331066-ediowz4s 135 7 because because IN cord-331066-ediowz4s 135 8 the the DT cord-331066-ediowz4s 135 9 corresponding correspond VBG cord-331066-ediowz4s 135 10 approximately approximately RB cord-331066-ediowz4s 135 11 equidistant equidistant JJ cord-331066-ediowz4s 135 12 series series NN cord-331066-ediowz4s 135 13 can can MD cord-331066-ediowz4s 135 14 be be VB cord-331066-ediowz4s 135 15 pursued pursue VBN cord-331066-ediowz4s 135 16 in in IN cord-331066-ediowz4s 135 17 these these DT cord-331066-ediowz4s 135 18 plots plot NNS cord-331066-ediowz4s 135 19 ( ( -LRB- cord-331066-ediowz4s 135 20 the the DT cord-331066-ediowz4s 135 21 next next JJ cord-331066-ediowz4s 135 22 peaks peak NNS cord-331066-ediowz4s 135 23 are be VBP cord-331066-ediowz4s 135 24 shown show VBN cord-331066-ediowz4s 135 25 only only RB cord-331066-ediowz4s 135 26 for for IN cord-331066-ediowz4s 135 27 the the DT cord-331066-ediowz4s 135 28 most most RBS cord-331066-ediowz4s 135 29 pronounced pronounce VBN cord-331066-ediowz4s 135 30 patterns pattern NNS cord-331066-ediowz4s 135 31 with with IN cord-331066-ediowz4s 135 32 periodicity periodicity NN cord-331066-ediowz4s 135 33 p p NN cord-331066-ediowz4s 135 34 ¼ ¼ NNP cord-331066-ediowz4s 135 35 54 54 CD cord-331066-ediowz4s 135 36 ) ) -RRB- cord-331066-ediowz4s 135 37 . . . cord-331066-ediowz4s 136 1 For for IN cord-331066-ediowz4s 136 2 the the DT cord-331066-ediowz4s 136 3 further further JJ cord-331066-ediowz4s 136 4 analysis analysis NN cord-331066-ediowz4s 136 5 and and CC cord-331066-ediowz4s 136 6 as as IN cord-331066-ediowz4s 136 7 a a DT cord-331066-ediowz4s 136 8 cross cross NN cord-331066-ediowz4s 136 9 - - NN cord-331066-ediowz4s 136 10 check check NN cord-331066-ediowz4s 136 11 of of IN cord-331066-ediowz4s 136 12 the the DT cord-331066-ediowz4s 136 13 above above JJ cord-331066-ediowz4s 136 14 results result NNS cord-331066-ediowz4s 136 15 , , , cord-331066-ediowz4s 136 16 the the DT cord-331066-ediowz4s 136 17 NCF NCF NNP cord-331066-ediowz4s 136 18 and and CC cord-331066-ediowz4s 136 19 DFT DFT NNP cord-331066-ediowz4s 136 20 spectra spectrum NNS cord-331066-ediowz4s 136 21 were be VBD cord-331066-ediowz4s 136 22 computed compute VBN cord-331066-ediowz4s 136 23 for for IN cord-331066-ediowz4s 136 24 the the DT cord-331066-ediowz4s 136 25 set set NN cord-331066-ediowz4s 136 26 of of IN cord-331066-ediowz4s 136 27 nonoverlapping nonoverlappe VBG cord-331066-ediowz4s 136 28 windows window NNS cord-331066-ediowz4s 136 29 of of IN cord-331066-ediowz4s 136 30 width width NN cord-331066-ediowz4s 136 31 432 432 CD cord-331066-ediowz4s 136 32 nt nt RB cord-331066-ediowz4s 136 33 . . . cord-331066-ediowz4s 137 1 The the DT cord-331066-ediowz4s 137 2 3 3 CD cord-331066-ediowz4s 137 3 0 0 CD cord-331066-ediowz4s 137 4 -end -end : cord-331066-ediowz4s 137 5 windows window NNS cord-331066-ediowz4s 137 6 # # $ cord-331066-ediowz4s 137 7 69 69 CD cord-331066-ediowz4s 137 8 were be VBD cord-331066-ediowz4s 137 9 incomplete incomplete JJ cord-331066-ediowz4s 137 10 for for IN cord-331066-ediowz4s 137 11 the the DT cord-331066-ediowz4s 137 12 genomes genome NNS cord-331066-ediowz4s 137 13 of of IN cord-331066-ediowz4s 137 14 NC_004718 NC_004718 NNP cord-331066-ediowz4s 137 15 , , , cord-331066-ediowz4s 137 16 MT371038 MT371038 NNP cord-331066-ediowz4s 137 17 and and CC cord-331066-ediowz4s 137 18 MT371037 MT371037 NNP cord-331066-ediowz4s 137 19 . . . cord-331066-ediowz4s 138 1 The the DT cord-331066-ediowz4s 138 2 characteristics characteristic NNS cord-331066-ediowz4s 138 3 used use VBN cord-331066-ediowz4s 138 4 in in IN cord-331066-ediowz4s 138 5 our -PRON- PRP$ cord-331066-ediowz4s 138 6 analysis analysis NN cord-331066-ediowz4s 138 7 are be VBP cord-331066-ediowz4s 138 8 robust robust JJ cord-331066-ediowz4s 138 9 with with IN cord-331066-ediowz4s 138 10 respect respect NN cord-331066-ediowz4s 138 11 to to IN cord-331066-ediowz4s 138 12 the the DT cord-331066-ediowz4s 138 13 length length NN cord-331066-ediowz4s 138 14 of of IN cord-331066-ediowz4s 138 15 window window NN cord-331066-ediowz4s 138 16 . . . cord-331066-ediowz4s 139 1 The the DT cord-331066-ediowz4s 139 2 normalized normalized JJ cord-331066-ediowz4s 139 3 deviations deviation NNS cord-331066-ediowz4s 139 4 for for IN cord-331066-ediowz4s 139 5 NCF NCF NNP cord-331066-ediowz4s 139 6 were be VBD cord-331066-ediowz4s 139 7 calculated calculate VBN cord-331066-ediowz4s 139 8 using use VBG cord-331066-ediowz4s 139 9 Equations equation NNS cord-331066-ediowz4s 139 10 ( ( -LRB- cord-331066-ediowz4s 139 11 26 26 CD cord-331066-ediowz4s 139 12 ) ) -RRB- cord-331066-ediowz4s 139 13 and and CC cord-331066-ediowz4s 139 14 ( ( -LRB- cord-331066-ediowz4s 139 15 27 27 CD cord-331066-ediowz4s 139 16 ) ) -RRB- cord-331066-ediowz4s 139 17 and and CC cord-331066-ediowz4s 139 18 replacing replace VBG cord-331066-ediowz4s 139 19 peaks peak NNS cord-331066-ediowz4s 139 20 corresponding correspond VBG cord-331066-ediowz4s 139 21 to to IN cord-331066-ediowz4s 139 22 the the DT cord-331066-ediowz4s 139 23 triplet triplet NN cord-331066-ediowz4s 139 24 periodicity periodicity NN cord-331066-ediowz4s 139 25 p p NNP cord-331066-ediowz4s 139 26 ¼ ¼ NNP cord-331066-ediowz4s 139 27 3 3 CD cord-331066-ediowz4s 139 28 by by IN cord-331066-ediowz4s 139 29 the the DT cord-331066-ediowz4s 139 30 heights height NNS cord-331066-ediowz4s 139 31 corresponding correspond VBG cord-331066-ediowz4s 139 32 to to IN cord-331066-ediowz4s 139 33 Pr Pr NNP cord-331066-ediowz4s 139 34 ¼ ¼ CD cord-331066-ediowz4s 139 35 0.05 0.05 CD cord-331066-ediowz4s 139 36 in in IN cord-331066-ediowz4s 139 37 the the DT cord-331066-ediowz4s 139 38 Rayleigh Rayleigh NNP cord-331066-ediowz4s 139 39 spectra spectrum NNS cord-331066-ediowz4s 139 40 . . . cord-331066-ediowz4s 140 1 The the DT cord-331066-ediowz4s 140 2 similar similar JJ cord-331066-ediowz4s 140 3 cut cut VBN cord-331066-ediowz4s 140 4 - - HYPH cord-331066-ediowz4s 140 5 off off NN cord-331066-ediowz4s 140 6 was be VBD cord-331066-ediowz4s 140 7 used use VBN cord-331066-ediowz4s 140 8 after after IN cord-331066-ediowz4s 140 9 the the DT cord-331066-ediowz4s 140 10 calculations calculation NNS cord-331066-ediowz4s 140 11 of of IN cord-331066-ediowz4s 140 12 the the DT cord-331066-ediowz4s 140 13 DFT DFT NNP cord-331066-ediowz4s 140 14 spectra spectra NN cord-331066-ediowz4s 140 15 within within IN cord-331066-ediowz4s 140 16 windows window NNS cord-331066-ediowz4s 140 17 . . . cord-331066-ediowz4s 141 1 The the DT cord-331066-ediowz4s 141 2 correlograms correlogram NNS cord-331066-ediowz4s 141 3 obtained obtain VBN cord-331066-ediowz4s 141 4 by by IN cord-331066-ediowz4s 141 5 averaging average VBG cord-331066-ediowz4s 141 6 of of IN cord-331066-ediowz4s 141 7 the the DT cord-331066-ediowz4s 141 8 plots plot NNS cord-331066-ediowz4s 141 9 for for IN cord-331066-ediowz4s 141 10 normalized normalized JJ cord-331066-ediowz4s 141 11 NCF NCF NNP cord-331066-ediowz4s 141 12 deviations deviation NNS cord-331066-ediowz4s 141 13 for for IN cord-331066-ediowz4s 141 14 the the DT cord-331066-ediowz4s 141 15 sums sum NNS cord-331066-ediowz4s 141 16 defined define VBN cord-331066-ediowz4s 141 17 by by IN cord-331066-ediowz4s 141 18 Equation equation NN cord-331066-ediowz4s 141 19 ( ( -LRB- cord-331066-ediowz4s 141 20 24 24 CD cord-331066-ediowz4s 141 21 ) ) -RRB- cord-331066-ediowz4s 141 22 are be VBP cord-331066-ediowz4s 141 23 shown show VBN cord-331066-ediowz4s 141 24 in in IN cord-331066-ediowz4s 141 25 Figure Figure NNP cord-331066-ediowz4s 141 26 3 3 CD cord-331066-ediowz4s 141 27 . . . cord-331066-ediowz4s 142 1 The the DT cord-331066-ediowz4s 142 2 significance significance NN cord-331066-ediowz4s 142 3 threshold threshold NN cord-331066-ediowz4s 142 4 of of IN cord-331066-ediowz4s 142 5 Pr Pr NNP cord-331066-ediowz4s 142 6 ¼ ¼ CD cord-331066-ediowz4s 142 7 0.05 0.05 CD cord-331066-ediowz4s 142 8 for for IN cord-331066-ediowz4s 142 9 the the DT cord-331066-ediowz4s 142 10 correlograms correlogram NNS cord-331066-ediowz4s 142 11 corresponds correspond VBZ cord-331066-ediowz4s 142 12 to to IN cord-331066-ediowz4s 142 13 61:96= 61:96= CD cord-331066-ediowz4s 143 1 N N NNP cord-331066-ediowz4s 143 2 1=2 1=2 CD cord-331066-ediowz4s 143 3 w w NN cord-331066-ediowz4s 143 4 , , , cord-331066-ediowz4s 144 1 where where WRB cord-331066-ediowz4s 144 2 N N NNP cord-331066-ediowz4s 144 3 w w NNP cord-331066-ediowz4s 144 4 is be VBZ cord-331066-ediowz4s 144 5 the the DT cord-331066-ediowz4s 144 6 total total JJ cord-331066-ediowz4s 144 7 number number NN cord-331066-ediowz4s 144 8 of of IN cord-331066-ediowz4s 144 9 windows window NNS cord-331066-ediowz4s 144 10 . . . cord-331066-ediowz4s 145 1 In in IN cord-331066-ediowz4s 145 2 all all DT cord-331066-ediowz4s 145 3 genomes genome NNS cord-331066-ediowz4s 145 4 the the DT cord-331066-ediowz4s 145 5 deviations deviation NNS cord-331066-ediowz4s 145 6 for for IN cord-331066-ediowz4s 145 7 m m NN cord-331066-ediowz4s 145 8 0 0 CD cord-331066-ediowz4s 145 9 ¼ ¼ CD cord-331066-ediowz4s 145 10 54 54 CD cord-331066-ediowz4s 145 11 were be VBD cord-331066-ediowz4s 145 12 the the DT cord-331066-ediowz4s 145 13 highest high JJS cord-331066-ediowz4s 145 14 and and CC cord-331066-ediowz4s 145 15 the the DT cord-331066-ediowz4s 145 16 deviations deviation NNS cord-331066-ediowz4s 145 17 with with IN cord-331066-ediowz4s 145 18 m m NNP cord-331066-ediowz4s 145 19 0 0 CD cord-331066-ediowz4s 145 20 ¼ ¼ NNP cord-331066-ediowz4s 145 21 108 108 CD cord-331066-ediowz4s 145 22 were be VBD cord-331066-ediowz4s 145 23 significant significant JJ cord-331066-ediowz4s 145 24 as as RB cord-331066-ediowz4s 145 25 well well RB cord-331066-ediowz4s 145 26 . . . cord-331066-ediowz4s 146 1 For for IN cord-331066-ediowz4s 146 2 SARS SARS NNP cord-331066-ediowz4s 146 3 - - HYPH cord-331066-ediowz4s 146 4 CoV CoV NNP cord-331066-ediowz4s 146 5 the the DT cord-331066-ediowz4s 146 6 deviations deviation NNS cord-331066-ediowz4s 146 7 with with IN cord-331066-ediowz4s 146 8 m m NNP cord-331066-ediowz4s 146 9 0 0 CD cord-331066-ediowz4s 146 10 ¼ ¼ NNP cord-331066-ediowz4s 146 11 216 216 CD cord-331066-ediowz4s 146 12 ( ( -LRB- cord-331066-ediowz4s 146 13 ¼4 ¼4 NNP cord-331066-ediowz4s 146 14 Â â CD cord-331066-ediowz4s 146 15 54 54 CD cord-331066-ediowz4s 146 16 ) ) -RRB- cord-331066-ediowz4s 146 17 were be VBD cord-331066-ediowz4s 146 18 also also RB cord-331066-ediowz4s 146 19 significant significant JJ cord-331066-ediowz4s 146 20 . . . cord-331066-ediowz4s 147 1 The the DT cord-331066-ediowz4s 147 2 next next JJ cord-331066-ediowz4s 147 3 characteristic characteristic JJ cord-331066-ediowz4s 147 4 high high JJ cord-331066-ediowz4s 147 5 deviations deviation NNS cord-331066-ediowz4s 147 6 for for IN cord-331066-ediowz4s 147 7 SARS SARS NNP cord-331066-ediowz4s 147 8 - - HYPH cord-331066-ediowz4s 147 9 CoV CoV NNP cord-331066-ediowz4s 147 10 were be VBD cord-331066-ediowz4s 147 11 for for IN cord-331066-ediowz4s 147 12 m m NN cord-331066-ediowz4s 147 13 0 0 CD cord-331066-ediowz4s 147 14 ¼ ¼ CD cord-331066-ediowz4s 147 15 87 87 CD cord-331066-ediowz4s 147 16 , , , cord-331066-ediowz4s 147 17 while while IN cord-331066-ediowz4s 147 18 in in IN cord-331066-ediowz4s 147 19 the the DT cord-331066-ediowz4s 147 20 isolates isolate NNS cord-331066-ediowz4s 147 21 of of IN cord-331066-ediowz4s 147 22 SARS SARS NNP cord-331066-ediowz4s 147 23 - - : cord-331066-ediowz4s 147 24 CoV-2 CoV-2 NNP cord-331066-ediowz4s 147 25 they -PRON- PRP cord-331066-ediowz4s 147 26 were be VBD cord-331066-ediowz4s 147 27 for for IN cord-331066-ediowz4s 147 28 m m NN cord-331066-ediowz4s 147 29 0 0 CD cord-331066-ediowz4s 147 30 ¼ ¼ CD cord-331066-ediowz4s 147 31 84 84 CD cord-331066-ediowz4s 147 32 . . . cord-331066-ediowz4s 148 1 The the DT cord-331066-ediowz4s 148 2 corresponding correspond VBG cord-331066-ediowz4s 148 3 periodograms periodogram NNS cord-331066-ediowz4s 148 4 obtained obtain VBN cord-331066-ediowz4s 148 5 by by IN cord-331066-ediowz4s 148 6 the the DT cord-331066-ediowz4s 148 7 averaging averaging NN cord-331066-ediowz4s 148 8 of of IN cord-331066-ediowz4s 148 9 the the DT cord-331066-ediowz4s 148 10 DFT DFT NNP cord-331066-ediowz4s 148 11 spectra spectra NN cord-331066-ediowz4s 148 12 over over IN cord-331066-ediowz4s 148 13 windows window NNS cord-331066-ediowz4s 148 14 were be VBD cord-331066-ediowz4s 148 15 then then RB cord-331066-ediowz4s 148 16 re re VBN cord-331066-ediowz4s 148 17 - - VBN cord-331066-ediowz4s 148 18 computed compute VBN cord-331066-ediowz4s 149 1 by by IN cord-331066-ediowz4s 149 2 DDFT DDFT NNP cord-331066-ediowz4s 149 3 ( ( -LRB- cord-331066-ediowz4s 149 4 Chechetkin Chechetkin NNP cord-331066-ediowz4s 149 5 & & CC cord-331066-ediowz4s 149 6 Lobzin Lobzin NNP cord-331066-ediowz4s 149 7 , , , cord-331066-ediowz4s 149 8 2020a 2020a CD cord-331066-ediowz4s 149 9 ) ) -RRB- cord-331066-ediowz4s 149 10 . . . cord-331066-ediowz4s 150 1 Due due IN cord-331066-ediowz4s 150 2 to to IN cord-331066-ediowz4s 150 3 the the DT cord-331066-ediowz4s 150 4 restrictions restriction NNS cord-331066-ediowz4s 150 5 related relate VBN cord-331066-ediowz4s 150 6 to to IN cord-331066-ediowz4s 150 7 the the DT cord-331066-ediowz4s 150 8 applicability applicability NN cord-331066-ediowz4s 150 9 of of IN cord-331066-ediowz4s 150 10 DDFT DDFT NNP cord-331066-ediowz4s 150 11 , , , cord-331066-ediowz4s 150 12 the the DT cord-331066-ediowz4s 150 13 left left JJ cord-331066-ediowz4s 150 14 boundary boundary NN cord-331066-ediowz4s 150 15 ( ( -LRB- cord-331066-ediowz4s 150 16 26 26 CD cord-331066-ediowz4s 150 17 ) ) -RRB- cord-331066-ediowz4s 150 18 and and CC cord-331066-ediowz4s 150 19 ( ( -LRB- cord-331066-ediowz4s 150 20 27 27 CD cord-331066-ediowz4s 150 21 ) ) -RRB- cord-331066-ediowz4s 150 22 . . . cord-331066-ediowz4s 151 1 The the DT cord-331066-ediowz4s 151 2 initial initial JJ cord-331066-ediowz4s 151 3 ranges range NNS cord-331066-ediowz4s 151 4 of of IN cord-331066-ediowz4s 151 5 plots plot NNS cord-331066-ediowz4s 151 6 shown show VBN cord-331066-ediowz4s 151 7 in in IN cord-331066-ediowz4s 151 8 the the DT cord-331066-ediowz4s 151 9 inserts insert NNS cord-331066-ediowz4s 151 10 were be VBD cord-331066-ediowz4s 151 11 re re VBN cord-331066-ediowz4s 151 12 - - VBN cord-331066-ediowz4s 151 13 calculated calculate VBN cord-331066-ediowz4s 151 14 by by IN cord-331066-ediowz4s 151 15 replacing replace VBG cord-331066-ediowz4s 151 16 the the DT cord-331066-ediowz4s 151 17 highest high JJS cord-331066-ediowz4s 151 18 Fourier Fourier NNP cord-331066-ediowz4s 151 19 harmonics harmonic NNS cord-331066-ediowz4s 151 20 by by IN cord-331066-ediowz4s 151 21 the the DT cord-331066-ediowz4s 151 22 peaks peak NNS cord-331066-ediowz4s 151 23 defined define VBN cord-331066-ediowz4s 151 24 by by IN cord-331066-ediowz4s 151 25 extreme extreme JJ cord-331066-ediowz4s 151 26 value value NN cord-331066-ediowz4s 151 27 statistics statistic NNS cord-331066-ediowz4s 151 28 in in IN cord-331066-ediowz4s 151 29 the the DT cord-331066-ediowz4s 151 30 DFT DFT NNP cord-331066-ediowz4s 151 31 spectra spectra NN cord-331066-ediowz4s 151 32 . . . cord-331066-ediowz4s 152 1 The the DT cord-331066-ediowz4s 152 2 characteristic characteristic JJ cord-331066-ediowz4s 152 3 spacings spacing NNS cord-331066-ediowz4s 152 4 m m NN cord-331066-ediowz4s 152 5 0 0 CD cord-331066-ediowz4s 152 6 are be VBP cord-331066-ediowz4s 152 7 explicitly explicitly RB cord-331066-ediowz4s 152 8 marked mark VBN cord-331066-ediowz4s 152 9 by by IN cord-331066-ediowz4s 152 10 the the DT cord-331066-ediowz4s 152 11 arrows arrow NNS cord-331066-ediowz4s 152 12 . . . cord-331066-ediowz4s 153 1 The the DT cord-331066-ediowz4s 153 2 horizontal horizontal JJ cord-331066-ediowz4s 153 3 lines line NNS cord-331066-ediowz4s 153 4 correspond correspond VBP cord-331066-ediowz4s 153 5 to to IN cord-331066-ediowz4s 153 6 the the DT cord-331066-ediowz4s 153 7 significance significance NN cord-331066-ediowz4s 153 8 Pr Pr NNP cord-331066-ediowz4s 153 9 ¼ ¼ NNP cord-331066-ediowz4s 153 10 0.05 0.05 CD cord-331066-ediowz4s 153 11 for for IN cord-331066-ediowz4s 153 12 the the DT cord-331066-ediowz4s 153 13 reshuffled reshuffle VBN cord-331066-ediowz4s 153 14 random random JJ cord-331066-ediowz4s 153 15 sequences sequence NNS cord-331066-ediowz4s 153 16 . . . cord-331066-ediowz4s 154 1 The the DT cord-331066-ediowz4s 154 2 panels panel NNS cord-331066-ediowz4s 154 3 A a NN cord-331066-ediowz4s 154 4 - - HYPH cord-331066-ediowz4s 154 5 D d NN cord-331066-ediowz4s 154 6 correspond correspond VBP cord-331066-ediowz4s 154 7 to to IN cord-331066-ediowz4s 154 8 the the DT cord-331066-ediowz4s 154 9 nucleotides nucleotide NNS cord-331066-ediowz4s 154 10 of of IN cord-331066-ediowz4s 154 11 particular particular JJ cord-331066-ediowz4s 154 12 types type NNS cord-331066-ediowz4s 154 13 in in IN cord-331066-ediowz4s 154 14 the the DT cord-331066-ediowz4s 154 15 genome genome NN cord-331066-ediowz4s 154 16 of of IN cord-331066-ediowz4s 154 17 SARS SARS NNP cord-331066-ediowz4s 154 18 - - HYPH cord-331066-ediowz4s 154 19 CoV CoV NNP cord-331066-ediowz4s 154 20 ( ( -LRB- cord-331066-ediowz4s 154 21 accession accession NN cord-331066-ediowz4s 154 22 NC_004718 NC_004718 NNP cord-331066-ediowz4s 154 23 ) ) -RRB- cord-331066-ediowz4s 154 24 . . . cord-331066-ediowz4s 155 1 in in IN cord-331066-ediowz4s 155 2 the the DT cord-331066-ediowz4s 155 3 DDFT DDFT NNP cord-331066-ediowz4s 155 4 spectra spectra NN cord-331066-ediowz4s 155 5 is be VBZ cord-331066-ediowz4s 155 6 positioned position VBN cord-331066-ediowz4s 155 7 at at IN cord-331066-ediowz4s 155 8 n n NN cord-331066-ediowz4s 155 9 ' ' CC cord-331066-ediowz4s 155 10 ¼10 ¼10 NN cord-331066-ediowz4s 155 11 . . . cord-331066-ediowz4s 156 1 Then then RB cord-331066-ediowz4s 156 2 , , , cord-331066-ediowz4s 156 3 the the DT cord-331066-ediowz4s 156 4 DDFT DDFT NNP cord-331066-ediowz4s 156 5 spectra spectrum NNS cord-331066-ediowz4s 156 6 were be VBD cord-331066-ediowz4s 156 7 renormalized renormalize VBN cord-331066-ediowz4s 156 8 in in IN cord-331066-ediowz4s 156 9 this this DT cord-331066-ediowz4s 156 10 range range NN cord-331066-ediowz4s 156 11 . . . cord-331066-ediowz4s 157 1 The the DT cord-331066-ediowz4s 157 2 resulting result VBG cord-331066-ediowz4s 157 3 DDFT DDFT NNP cord-331066-ediowz4s 157 4 spectra spectra NN cord-331066-ediowz4s 157 5 for for IN cord-331066-ediowz4s 157 6 the the DT cord-331066-ediowz4s 157 7 sums sum NNS cord-331066-ediowz4s 157 8 defined define VBN cord-331066-ediowz4s 157 9 by by IN cord-331066-ediowz4s 157 10 Equation equation NN cord-331066-ediowz4s 157 11 ( ( -LRB- cord-331066-ediowz4s 157 12 7 7 CD cord-331066-ediowz4s 157 13 ) ) -RRB- cord-331066-ediowz4s 157 14 are be VBP cord-331066-ediowz4s 157 15 shown show VBN cord-331066-ediowz4s 157 16 in in IN cord-331066-ediowz4s 157 17 Figure Figure NNP cord-331066-ediowz4s 157 18 4 4 CD cord-331066-ediowz4s 157 19 . . . cord-331066-ediowz4s 158 1 Again again RB cord-331066-ediowz4s 158 2 , , , cord-331066-ediowz4s 158 3 the the DT cord-331066-ediowz4s 158 4 harmonic harmonic NN cord-331066-ediowz4s 158 5 with with IN cord-331066-ediowz4s 158 6 n n NNP cord-331066-ediowz4s 158 7 ' ' POS cord-331066-ediowz4s 158 8 ¼ ¼ NNP cord-331066-ediowz4s 158 9 27 27 CD cord-331066-ediowz4s 158 10 , , , cord-331066-ediowz4s 158 11 p p NN cord-331066-ediowz4s 158 12 ' ' POS cord-331066-ediowz4s 158 13 ¼ ¼ NNP cord-331066-ediowz4s 158 14 54.2 54.2 CD cord-331066-ediowz4s 158 15 was be VBD cord-331066-ediowz4s 158 16 reproducibly reproducibly RB cord-331066-ediowz4s 158 17 significant significant JJ cord-331066-ediowz4s 158 18 and and CC cord-331066-ediowz4s 158 19 the the DT cord-331066-ediowz4s 158 20 highest high JJS cord-331066-ediowz4s 158 21 in in IN cord-331066-ediowz4s 158 22 the the DT cord-331066-ediowz4s 158 23 range range NN cord-331066-ediowz4s 158 24 under under IN cord-331066-ediowz4s 158 25 study study NN cord-331066-ediowz4s 158 26 for for IN cord-331066-ediowz4s 158 27 all all DT cord-331066-ediowz4s 158 28 genomes genome NNS cord-331066-ediowz4s 158 29 . . . cord-331066-ediowz4s 159 1 For for IN cord-331066-ediowz4s 159 2 SARS SARS NNP cord-331066-ediowz4s 159 3 - - HYPH cord-331066-ediowz4s 159 4 CoV CoV NNP cord-331066-ediowz4s 159 5 the the DT cord-331066-ediowz4s 159 6 harmonic harmonic NN cord-331066-ediowz4s 159 7 with with IN cord-331066-ediowz4s 159 8 n n NNP cord-331066-ediowz4s 159 9 ' ' POS cord-331066-ediowz4s 159 10 ¼ ¼ NNP cord-331066-ediowz4s 159 11 43 43 CD cord-331066-ediowz4s 159 12 , , , cord-331066-ediowz4s 159 13 p p NN cord-331066-ediowz4s 159 14 ' ' POS cord-331066-ediowz4s 159 15 ¼ ¼ CD cord-331066-ediowz4s 159 16 86.4 86.4 CD cord-331066-ediowz4s 159 17 was be VBD cord-331066-ediowz4s 159 18 also also RB cord-331066-ediowz4s 159 19 significant significant JJ cord-331066-ediowz4s 159 20 , , , cord-331066-ediowz4s 159 21 whereas whereas IN cord-331066-ediowz4s 159 22 for for IN cord-331066-ediowz4s 159 23 the the DT cord-331066-ediowz4s 159 24 isolates isolate NNS cord-331066-ediowz4s 159 25 of of IN cord-331066-ediowz4s 159 26 SARS SARS NNP cord-331066-ediowz4s 159 27 - - : cord-331066-ediowz4s 159 28 CoV-2 CoV-2 NNP cord-331066-ediowz4s 159 29 the the DT cord-331066-ediowz4s 159 30 harmonic harmonic NN cord-331066-ediowz4s 159 31 with with IN cord-331066-ediowz4s 159 32 n n NNP cord-331066-ediowz4s 159 33 ' ' POS cord-331066-ediowz4s 159 34 ¼ ¼ NNP cord-331066-ediowz4s 159 35 42 42 CD cord-331066-ediowz4s 159 36 , , , cord-331066-ediowz4s 159 37 p p NN cord-331066-ediowz4s 159 38 ' ' POS cord-331066-ediowz4s 159 39 ¼ ¼ CD cord-331066-ediowz4s 159 40 84.4 84.4 CD cord-331066-ediowz4s 159 41 appeared appear VBD cord-331066-ediowz4s 159 42 to to TO cord-331066-ediowz4s 159 43 be be VB cord-331066-ediowz4s 159 44 insignificant insignificant JJ cord-331066-ediowz4s 159 45 . . . cord-331066-ediowz4s 160 1 The the DT cord-331066-ediowz4s 160 2 harmonic harmonic NN cord-331066-ediowz4s 160 3 with with IN cord-331066-ediowz4s 160 4 n n NNP cord-331066-ediowz4s 160 5 ' ' POS cord-331066-ediowz4s 160 6 ¼ ¼ NNP cord-331066-ediowz4s 160 7 57 57 CD cord-331066-ediowz4s 160 8 , , , cord-331066-ediowz4s 160 9 p p NN cord-331066-ediowz4s 160 10 ' ' POS cord-331066-ediowz4s 160 11 ¼ ¼ NNP cord-331066-ediowz4s 160 12 114.5 114.5 CD cord-331066-ediowz4s 160 13 for for IN cord-331066-ediowz4s 160 14 SARS SARS NNP cord-331066-ediowz4s 160 15 - - HYPH cord-331066-ediowz4s 160 16 CoV CoV NNP cord-331066-ediowz4s 160 17 can can MD cord-331066-ediowz4s 160 18 be be VB cord-331066-ediowz4s 160 19 treated treat VBN cord-331066-ediowz4s 160 20 as as IN cord-331066-ediowz4s 160 21 a a DT cord-331066-ediowz4s 160 22 distorted distorted JJ cord-331066-ediowz4s 160 23 and and CC cord-331066-ediowz4s 160 24 modified modify VBN cord-331066-ediowz4s 160 25 doubled double VBD cord-331066-ediowz4s 160 26 period period NN cord-331066-ediowz4s 160 27 p p NN cord-331066-ediowz4s 160 28 ¼ ¼ NNP cord-331066-ediowz4s 160 29 54 54 CD cord-331066-ediowz4s 160 30 ( ( -LRB- cord-331066-ediowz4s 160 31 typically typically RB cord-331066-ediowz4s 160 32 of of IN cord-331066-ediowz4s 160 33 hidden hide VBN cord-331066-ediowz4s 160 34 fuzzy fuzzy JJ cord-331066-ediowz4s 160 35 repeating repeat VBG cord-331066-ediowz4s 160 36 patterns pattern NNS cord-331066-ediowz4s 160 37 ) ) -RRB- cord-331066-ediowz4s 160 38 . . . cord-331066-ediowz4s 161 1 Thus thus RB cord-331066-ediowz4s 161 2 , , , cord-331066-ediowz4s 161 3 combining combine VBG cord-331066-ediowz4s 161 4 correlograms correlogram NNS cord-331066-ediowz4s 161 5 for for IN cord-331066-ediowz4s 161 6 NCF NCF NNP cord-331066-ediowz4s 161 7 with with IN cord-331066-ediowz4s 161 8 the the DT cord-331066-ediowz4s 161 9 analysis analysis NN cord-331066-ediowz4s 161 10 of of IN cord-331066-ediowz4s 161 11 periodograms periodogram NNS cord-331066-ediowz4s 161 12 by by IN cord-331066-ediowz4s 161 13 DDFT DDFT NNP cord-331066-ediowz4s 161 14 reveals reveal VBZ cord-331066-ediowz4s 161 15 clearly clearly RB cord-331066-ediowz4s 161 16 the the DT cord-331066-ediowz4s 161 17 persistently persistently RB cord-331066-ediowz4s 161 18 reproducible reproducible JJ cord-331066-ediowz4s 161 19 quasi quasi JJ cord-331066-ediowz4s 161 20 - - JJ cord-331066-ediowz4s 161 21 periodic periodic JJ cord-331066-ediowz4s 161 22 patterns pattern NNS cord-331066-ediowz4s 161 23 with with IN cord-331066-ediowz4s 161 24 the the DT cord-331066-ediowz4s 161 25 period period NN cord-331066-ediowz4s 161 26 p p NN cord-331066-ediowz4s 161 27 % % NN cord-331066-ediowz4s 161 28 54 54 CD cord-331066-ediowz4s 161 29 in in IN cord-331066-ediowz4s 161 30 all all DT cord-331066-ediowz4s 161 31 genomes genome NNS cord-331066-ediowz4s 161 32 and and CC cord-331066-ediowz4s 161 33 indicates indicate VBZ cord-331066-ediowz4s 161 34 the the DT cord-331066-ediowz4s 161 35 relevance relevance NN cord-331066-ediowz4s 161 36 of of IN cord-331066-ediowz4s 161 37 less less RBR cord-331066-ediowz4s 161 38 robust robust JJ cord-331066-ediowz4s 161 39 patterns pattern NNS cord-331066-ediowz4s 161 40 with with IN cord-331066-ediowz4s 161 41 p p CD cord-331066-ediowz4s 161 42 % % NN cord-331066-ediowz4s 161 43 84 84 CD cord-331066-ediowz4s 161 44 and and CC cord-331066-ediowz4s 161 45 87 87 CD cord-331066-ediowz4s 161 46 . . . cord-331066-ediowz4s 162 1 To to TO cord-331066-ediowz4s 162 2 assess assess VB cord-331066-ediowz4s 162 3 the the DT cord-331066-ediowz4s 162 4 distribution distribution NN cord-331066-ediowz4s 162 5 of of IN cord-331066-ediowz4s 162 6 the the DT cord-331066-ediowz4s 162 7 detected detect VBN cord-331066-ediowz4s 162 8 patterns pattern NNS cord-331066-ediowz4s 162 9 over over IN cord-331066-ediowz4s 162 10 the the DT cord-331066-ediowz4s 162 11 genomes genome NNS cord-331066-ediowz4s 162 12 , , , cord-331066-ediowz4s 162 13 the the DT cord-331066-ediowz4s 162 14 normalized normalized JJ cord-331066-ediowz4s 162 15 deviations deviation NNS cord-331066-ediowz4s 162 16 for for IN cord-331066-ediowz4s 162 17 NCF NCF NNP cord-331066-ediowz4s 162 18 were be VBD cord-331066-ediowz4s 162 19 computed compute VBN cord-331066-ediowz4s 162 20 in in IN cord-331066-ediowz4s 162 21 separate separate JJ cord-331066-ediowz4s 162 22 windows window NNS cord-331066-ediowz4s 162 23 of of IN cord-331066-ediowz4s 162 24 width width NN cord-331066-ediowz4s 162 25 432 432 CD cord-331066-ediowz4s 162 26 nt nt RB cord-331066-ediowz4s 162 27 as as IN cord-331066-ediowz4s 162 28 described describe VBN cord-331066-ediowz4s 162 29 above above RB cord-331066-ediowz4s 162 30 . . . cord-331066-ediowz4s 163 1 The the DT cord-331066-ediowz4s 163 2 spacings spacing NNS cord-331066-ediowz4s 163 3 for for IN cord-331066-ediowz4s 163 4 NCF NCF NNP cord-331066-ediowz4s 163 5 m m NNP cord-331066-ediowz4s 163 6 0 0 CD cord-331066-ediowz4s 163 7 were be VBD cord-331066-ediowz4s 163 8 chosen choose VBN cord-331066-ediowz4s 163 9 by by IN cord-331066-ediowz4s 163 10 the the DT cord-331066-ediowz4s 163 11 correspondence correspondence NN cord-331066-ediowz4s 163 12 with with IN cord-331066-ediowz4s 163 13 the the DT cord-331066-ediowz4s 163 14 periods period NNS cord-331066-ediowz4s 163 15 of of IN cord-331066-ediowz4s 163 16 the the DT cord-331066-ediowz4s 163 17 detected detect VBN cord-331066-ediowz4s 163 18 patterns pattern NNS cord-331066-ediowz4s 163 19 and and CC cord-331066-ediowz4s 163 20 were be VBD cord-331066-ediowz4s 163 21 equal equal JJ cord-331066-ediowz4s 163 22 to to IN cord-331066-ediowz4s 163 23 54 54 CD cord-331066-ediowz4s 163 24 , , , cord-331066-ediowz4s 163 25 84 84 CD cord-331066-ediowz4s 163 26 and and CC cord-331066-ediowz4s 163 27 87 87 CD cord-331066-ediowz4s 163 28 , , , cord-331066-ediowz4s 163 29 respectively respectively RB cord-331066-ediowz4s 163 30 . . . cord-331066-ediowz4s 164 1 The the DT cord-331066-ediowz4s 164 2 resulting result VBG cord-331066-ediowz4s 164 3 plots plot NNS cord-331066-ediowz4s 164 4 for for IN cord-331066-ediowz4s 164 5 the the DT cord-331066-ediowz4s 164 6 sums sum NNS cord-331066-ediowz4s 164 7 defined define VBN cord-331066-ediowz4s 164 8 by by IN cord-331066-ediowz4s 164 9 Equation equation NN cord-331066-ediowz4s 164 10 ( ( -LRB- cord-331066-ediowz4s 164 11 24 24 CD cord-331066-ediowz4s 164 12 ) ) -RRB- cord-331066-ediowz4s 164 13 are be VBP cord-331066-ediowz4s 164 14 shown show VBN cord-331066-ediowz4s 164 15 in in IN cord-331066-ediowz4s 164 16 Figure figure NN cord-331066-ediowz4s 164 17 5 5 CD cord-331066-ediowz4s 164 18 . . . cord-331066-ediowz4s 165 1 The the DT cord-331066-ediowz4s 165 2 numerical numerical JJ cord-331066-ediowz4s 165 3 data datum NNS cord-331066-ediowz4s 165 4 for for IN cord-331066-ediowz4s 165 5 the the DT cord-331066-ediowz4s 165 6 profiles profile NNS cord-331066-ediowz4s 165 7 in in IN cord-331066-ediowz4s 165 8 Figure Figure NNP cord-331066-ediowz4s 165 9 5 5 CD cord-331066-ediowz4s 165 10 and and CC cord-331066-ediowz4s 165 11 for for IN cord-331066-ediowz4s 165 12 the the DT cord-331066-ediowz4s 165 13 profiles profile NNS cord-331066-ediowz4s 165 14 corresponding correspond VBG cord-331066-ediowz4s 165 15 to to IN cord-331066-ediowz4s 165 16 the the DT cord-331066-ediowz4s 165 17 nucleotides nucleotide NNS cord-331066-ediowz4s 165 18 of of IN cord-331066-ediowz4s 165 19 particular particular JJ cord-331066-ediowz4s 165 20 types type NNS cord-331066-ediowz4s 165 21 as as RB cord-331066-ediowz4s 165 22 well well RB cord-331066-ediowz4s 165 23 as as IN cord-331066-ediowz4s 165 24 to to IN cord-331066-ediowz4s 165 25 the the DT cord-331066-ediowz4s 165 26 sums sum NNS cord-331066-ediowz4s 165 27 defined define VBN cord-331066-ediowz4s 165 28 by by IN cord-331066-ediowz4s 165 29 Equations equation NNS cord-331066-ediowz4s 165 30 ( ( -LRB- cord-331066-ediowz4s 165 31 22 22 CD cord-331066-ediowz4s 165 32 ) ) -RRB- cord-331066-ediowz4s 165 33 and and CC cord-331066-ediowz4s 165 34 ( ( -LRB- cord-331066-ediowz4s 165 35 23 23 CD cord-331066-ediowz4s 165 36 ) ) -RRB- cord-331066-ediowz4s 165 37 are be VBP cord-331066-ediowz4s 165 38 collected collect VBN cord-331066-ediowz4s 165 39 in in IN cord-331066-ediowz4s 165 40 Supporting support VBG cord-331066-ediowz4s 165 41 Information Information NNP cord-331066-ediowz4s 165 42 S1 S1 NNP cord-331066-ediowz4s 165 43 . . . cord-331066-ediowz4s 166 1 We -PRON- PRP cord-331066-ediowz4s 166 2 assessed assess VBD cord-331066-ediowz4s 166 3 the the DT cord-331066-ediowz4s 166 4 correlations correlation NNS cord-331066-ediowz4s 166 5 between between IN cord-331066-ediowz4s 166 6 different different JJ cord-331066-ediowz4s 166 7 profiles profile NNS cord-331066-ediowz4s 166 8 by by IN cord-331066-ediowz4s 166 9 the the DT cord-331066-ediowz4s 166 10 Pearson Pearson NNP cord-331066-ediowz4s 166 11 correlation correlation NN cord-331066-ediowz4s 166 12 ( ( -LRB- cord-331066-ediowz4s 166 13 26 26 CD cord-331066-ediowz4s 166 14 ) ) -RRB- cord-331066-ediowz4s 166 15 and and CC cord-331066-ediowz4s 166 16 ( ( -LRB- cord-331066-ediowz4s 166 17 27 27 CD cord-331066-ediowz4s 166 18 ) ) -RRB- cord-331066-ediowz4s 166 19 . . . cord-331066-ediowz4s 167 1 The the DT cord-331066-ediowz4s 167 2 initial initial JJ cord-331066-ediowz4s 167 3 ranges range NNS cord-331066-ediowz4s 167 4 of of IN cord-331066-ediowz4s 167 5 plots plot NNS cord-331066-ediowz4s 167 6 shown show VBN cord-331066-ediowz4s 167 7 in in IN cord-331066-ediowz4s 167 8 the the DT cord-331066-ediowz4s 167 9 inserts insert NNS cord-331066-ediowz4s 167 10 were be VBD cord-331066-ediowz4s 167 11 re re VBN cord-331066-ediowz4s 167 12 - - VBN cord-331066-ediowz4s 167 13 calculated calculate VBN cord-331066-ediowz4s 167 14 by by IN cord-331066-ediowz4s 167 15 replacing replace VBG cord-331066-ediowz4s 167 16 the the DT cord-331066-ediowz4s 167 17 highest high JJS cord-331066-ediowz4s 167 18 Fourier Fourier NNP cord-331066-ediowz4s 167 19 harmonics harmonic NNS cord-331066-ediowz4s 167 20 by by IN cord-331066-ediowz4s 167 21 the the DT cord-331066-ediowz4s 167 22 peaks peak NNS cord-331066-ediowz4s 167 23 defined define VBN cord-331066-ediowz4s 167 24 by by IN cord-331066-ediowz4s 167 25 extreme extreme JJ cord-331066-ediowz4s 167 26 value value NN cord-331066-ediowz4s 167 27 statistics statistic NNS cord-331066-ediowz4s 167 28 in in IN cord-331066-ediowz4s 167 29 the the DT cord-331066-ediowz4s 167 30 DFT DFT NNP cord-331066-ediowz4s 167 31 spectra spectra NN cord-331066-ediowz4s 167 32 . . . cord-331066-ediowz4s 168 1 The the DT cord-331066-ediowz4s 168 2 characteristic characteristic JJ cord-331066-ediowz4s 168 3 spacings spacing NNS cord-331066-ediowz4s 168 4 m m NN cord-331066-ediowz4s 168 5 0 0 CD cord-331066-ediowz4s 168 6 are be VBP cord-331066-ediowz4s 168 7 explicitly explicitly RB cord-331066-ediowz4s 168 8 marked mark VBN cord-331066-ediowz4s 168 9 by by IN cord-331066-ediowz4s 168 10 the the DT cord-331066-ediowz4s 168 11 arrows arrow NNS cord-331066-ediowz4s 168 12 . . . cord-331066-ediowz4s 169 1 The the DT cord-331066-ediowz4s 169 2 horizontal horizontal JJ cord-331066-ediowz4s 169 3 lines line NNS cord-331066-ediowz4s 169 4 correspond correspond VBP cord-331066-ediowz4s 169 5 to to IN cord-331066-ediowz4s 169 6 the the DT cord-331066-ediowz4s 169 7 significance significance NN cord-331066-ediowz4s 169 8 Pr Pr NNP cord-331066-ediowz4s 169 9 ¼ ¼ NNP cord-331066-ediowz4s 169 10 0.05 0.05 CD cord-331066-ediowz4s 169 11 for for IN cord-331066-ediowz4s 169 12 the the DT cord-331066-ediowz4s 169 13 reshuffled reshuffle VBN cord-331066-ediowz4s 169 14 random random JJ cord-331066-ediowz4s 169 15 sequences sequence NNS cord-331066-ediowz4s 169 16 . . . cord-331066-ediowz4s 170 1 The the DT cord-331066-ediowz4s 170 2 panels panel NNS cord-331066-ediowz4s 170 3 A a NN cord-331066-ediowz4s 170 4 - - HYPH cord-331066-ediowz4s 170 5 D d NN cord-331066-ediowz4s 170 6 correspond correspond VBP cord-331066-ediowz4s 170 7 to to IN cord-331066-ediowz4s 170 8 the the DT cord-331066-ediowz4s 170 9 nucleotides nucleotide NNS cord-331066-ediowz4s 170 10 of of IN cord-331066-ediowz4s 170 11 particular particular JJ cord-331066-ediowz4s 170 12 types type NNS cord-331066-ediowz4s 170 13 in in IN cord-331066-ediowz4s 170 14 the the DT cord-331066-ediowz4s 170 15 genome genome NN cord-331066-ediowz4s 170 16 of of IN cord-331066-ediowz4s 170 17 SARS SARS NNP cord-331066-ediowz4s 170 18 - - HYPH cord-331066-ediowz4s 170 19 CoV-2 CoV-2 NNP cord-331066-ediowz4s 170 20 ( ( -LRB- cord-331066-ediowz4s 170 21 accession accession NN cord-331066-ediowz4s 170 22 MT371037 MT371037 NNP cord-331066-ediowz4s 170 23 ) ) -RRB- cord-331066-ediowz4s 170 24 . . . cord-331066-ediowz4s 171 1 coefficients coefficient NNS cord-331066-ediowz4s 171 2 . . . cord-331066-ediowz4s 172 1 The the DT cord-331066-ediowz4s 172 2 NCF NCF NNP cord-331066-ediowz4s 172 3 profiles profile NNS cord-331066-ediowz4s 172 4 for for IN cord-331066-ediowz4s 172 5 the the DT cord-331066-ediowz4s 172 6 different different JJ cord-331066-ediowz4s 172 7 genomes genome NNS cord-331066-ediowz4s 172 8 were be VBD cord-331066-ediowz4s 172 9 significantly significantly RB cord-331066-ediowz4s 172 10 correlated correlate VBN cord-331066-ediowz4s 172 11 for for IN cord-331066-ediowz4s 172 12 the the DT cord-331066-ediowz4s 172 13 same same JJ cord-331066-ediowz4s 172 14 spacings spacing NNS cord-331066-ediowz4s 172 15 m m NN cord-331066-ediowz4s 172 16 0 0 CD cord-331066-ediowz4s 172 17 , , , cord-331066-ediowz4s 172 18 while while IN cord-331066-ediowz4s 172 19 the the DT cord-331066-ediowz4s 172 20 profiles profile NNS cord-331066-ediowz4s 172 21 with with IN cord-331066-ediowz4s 172 22 the the DT cord-331066-ediowz4s 172 23 different different JJ cord-331066-ediowz4s 172 24 spacings spacing NNS cord-331066-ediowz4s 172 25 can can MD cord-331066-ediowz4s 172 26 be be VB cord-331066-ediowz4s 172 27 considered consider VBN cord-331066-ediowz4s 172 28 uncorrelated uncorrelated JJ cord-331066-ediowz4s 172 29 . . . cord-331066-ediowz4s 173 1 The the DT cord-331066-ediowz4s 173 2 coefficients coefficient NNS cord-331066-ediowz4s 173 3 for for IN cord-331066-ediowz4s 173 4 correlations correlation NNS cord-331066-ediowz4s 173 5 between between IN cord-331066-ediowz4s 173 6 profiles profile NNS cord-331066-ediowz4s 173 7 for for IN cord-331066-ediowz4s 173 8 SARS SARS NNP cord-331066-ediowz4s 173 9 - - HYPH cord-331066-ediowz4s 173 10 CoV CoV NNP cord-331066-ediowz4s 173 11 and and CC cord-331066-ediowz4s 173 12 three three CD cord-331066-ediowz4s 173 13 isolates isolate NNS cord-331066-ediowz4s 173 14 of of IN cord-331066-ediowz4s 173 15 SARS SARS NNP cord-331066-ediowz4s 173 16 - - HYPH cord-331066-ediowz4s 173 17 CoV-2 CoV-2 NNP cord-331066-ediowz4s 173 18 at at IN cord-331066-ediowz4s 173 19 m m CD cord-331066-ediowz4s 173 20 0 0 CD cord-331066-ediowz4s 173 21 ¼54 ¼54 NNP cord-331066-ediowz4s 173 22 were be VBD cord-331066-ediowz4s 173 23 0.623 0.623 CD cord-331066-ediowz4s 173 24 , , , cord-331066-ediowz4s 173 25 0.491 0.491 CD cord-331066-ediowz4s 173 26 and and CC cord-331066-ediowz4s 173 27 0.636 0.636 CD cord-331066-ediowz4s 174 1 ( ( -LRB- cord-331066-ediowz4s 174 2 Pr Pr NNP cord-331066-ediowz4s 174 3 < < XX cord-331066-ediowz4s 174 4 2 2 CD cord-331066-ediowz4s 174 5 Â â CD cord-331066-ediowz4s 174 6 10 10 CD cord-331066-ediowz4s 174 7 À5 à5 CD cord-331066-ediowz4s 174 8 for for IN cord-331066-ediowz4s 174 9 69 69 CD cord-331066-ediowz4s 174 10 components component NNS cord-331066-ediowz4s 174 11 ) ) -RRB- cord-331066-ediowz4s 174 12 . . . cord-331066-ediowz4s 175 1 The the DT cord-331066-ediowz4s 175 2 related related JJ cord-331066-ediowz4s 175 3 coefficients coefficient NNS cord-331066-ediowz4s 175 4 for for IN cord-331066-ediowz4s 175 5 the the DT cord-331066-ediowz4s 175 6 correlations correlation NNS cord-331066-ediowz4s 175 7 MT371038-MT295464 MT371038-MT295464 NNP cord-331066-ediowz4s 175 8 , , , cord-331066-ediowz4s 175 9 MT371038-MT371037 MT371038-MT371037 NNP cord-331066-ediowz4s 175 10 and and CC cord-331066-ediowz4s 175 11 MT295464-MT371037 MT295464-MT371037 NNP cord-331066-ediowz4s 175 12 were be VBD cord-331066-ediowz4s 175 13 0.817 0.817 CD cord-331066-ediowz4s 175 14 , , , cord-331066-ediowz4s 175 15 0.954 0.954 CD cord-331066-ediowz4s 175 16 and and CC cord-331066-ediowz4s 175 17 0.751 0.751 CD cord-331066-ediowz4s 175 18 . . . cord-331066-ediowz4s 176 1 Similar similar JJ cord-331066-ediowz4s 176 2 but but CC cord-331066-ediowz4s 176 3 a a DT cord-331066-ediowz4s 176 4 bit bit NN cord-331066-ediowz4s 176 5 lower low JJR cord-331066-ediowz4s 176 6 values value NNS cord-331066-ediowz4s 176 7 were be VBD cord-331066-ediowz4s 176 8 obtained obtain VBN cord-331066-ediowz4s 176 9 for for IN cord-331066-ediowz4s 176 10 the the DT cord-331066-ediowz4s 176 11 correlations correlation NNS cord-331066-ediowz4s 176 12 at at IN cord-331066-ediowz4s 176 13 two two CD cord-331066-ediowz4s 176 14 other other JJ cord-331066-ediowz4s 176 15 spacings spacing NNS cord-331066-ediowz4s 176 16 . . . cord-331066-ediowz4s 177 1 As as IN cord-331066-ediowz4s 177 2 supposed suppose VBN cord-331066-ediowz4s 177 3 , , , cord-331066-ediowz4s 177 4 the the DT cord-331066-ediowz4s 177 5 motifs motif NNS cord-331066-ediowz4s 177 6 detected detect VBD cord-331066-ediowz4s 177 7 at at IN cord-331066-ediowz4s 177 8 the the DT cord-331066-ediowz4s 177 9 different different JJ cord-331066-ediowz4s 177 10 spacings spacing NNS cord-331066-ediowz4s 177 11 m m NN cord-331066-ediowz4s 177 12 0 0 CD cord-331066-ediowz4s 177 13 are be VBP cord-331066-ediowz4s 177 14 related relate VBN cord-331066-ediowz4s 177 15 to to IN cord-331066-ediowz4s 177 16 the the DT cord-331066-ediowz4s 177 17 different different JJ cord-331066-ediowz4s 177 18 stages stage NNS cord-331066-ediowz4s 177 19 of of IN cord-331066-ediowz4s 177 20 ribonucleocapsid ribonucleocapsid NNP cord-331066-ediowz4s 177 21 assembly assembly NNP cord-331066-ediowz4s 177 22 / / SYM cord-331066-ediowz4s 177 23 packaging packaging NN cord-331066-ediowz4s 177 24 . . . cord-331066-ediowz4s 178 1 Such such JJ cord-331066-ediowz4s 178 2 motifs motif NNS cord-331066-ediowz4s 178 3 can can MD cord-331066-ediowz4s 178 4 be be VB cord-331066-ediowz4s 178 5 incorporated incorporate VBN cord-331066-ediowz4s 178 6 into into IN cord-331066-ediowz4s 178 7 the the DT cord-331066-ediowz4s 178 8 genomic genomic JJ cord-331066-ediowz4s 178 9 sequence sequence NN cord-331066-ediowz4s 178 10 by by IN cord-331066-ediowz4s 178 11 silent silent JJ cord-331066-ediowz4s 178 12 mutations mutation NNS cord-331066-ediowz4s 178 13 due due JJ cord-331066-ediowz4s 178 14 to to IN cord-331066-ediowz4s 178 15 the the DT cord-331066-ediowz4s 178 16 degeneracy degeneracy NN cord-331066-ediowz4s 178 17 of of IN cord-331066-ediowz4s 178 18 the the DT cord-331066-ediowz4s 178 19 genetic genetic JJ cord-331066-ediowz4s 178 20 code code NN cord-331066-ediowz4s 178 21 . . . cord-331066-ediowz4s 179 1 The the DT cord-331066-ediowz4s 179 2 regular regular JJ cord-331066-ediowz4s 179 3 near near RB cord-331066-ediowz4s 179 4 - - HYPH cord-331066-ediowz4s 179 5 by by IN cord-331066-ediowz4s 179 6 positioning positioning NN cord-331066-ediowz4s 179 7 of of IN cord-331066-ediowz4s 179 8 different different JJ cord-331066-ediowz4s 179 9 assembly assembly NN cord-331066-ediowz4s 179 10 / / SYM cord-331066-ediowz4s 179 11 packaging packaging NN cord-331066-ediowz4s 179 12 motifs motif NNS cord-331066-ediowz4s 179 13 would would MD cord-331066-ediowz4s 179 14 be be VB cord-331066-ediowz4s 179 15 too too RB cord-331066-ediowz4s 179 16 restrictive restrictive JJ cord-331066-ediowz4s 179 17 , , , cord-331066-ediowz4s 179 18 because because IN cord-331066-ediowz4s 179 19 the the DT cord-331066-ediowz4s 179 20 main main JJ cord-331066-ediowz4s 179 21 function function NN cord-331066-ediowz4s 179 22 of of IN cord-331066-ediowz4s 179 23 the the DT cord-331066-ediowz4s 179 24 genomic genomic JJ cord-331066-ediowz4s 179 25 sequence sequence NN cord-331066-ediowz4s 179 26 is be VBZ cord-331066-ediowz4s 179 27 coding code VBG cord-331066-ediowz4s 179 28 for for IN cord-331066-ediowz4s 179 29 proteins protein NNS cord-331066-ediowz4s 179 30 . . . cord-331066-ediowz4s 180 1 Therefore therefore RB cord-331066-ediowz4s 180 2 , , , cord-331066-ediowz4s 180 3 the the DT cord-331066-ediowz4s 180 4 windows window NNS cord-331066-ediowz4s 180 5 enriched enrich VBN cord-331066-ediowz4s 180 6 simultaneously simultaneously RB cord-331066-ediowz4s 180 7 by by IN cord-331066-ediowz4s 180 8 the the DT cord-331066-ediowz4s 180 9 motifs motif NNS cord-331066-ediowz4s 180 10 of of IN cord-331066-ediowz4s 180 11 different different JJ cord-331066-ediowz4s 180 12 types type NNS cord-331066-ediowz4s 180 13 are be VBP cord-331066-ediowz4s 180 14 especially especially RB cord-331066-ediowz4s 180 15 interesting interesting JJ cord-331066-ediowz4s 180 16 as as RB cord-331066-ediowz4s 180 17 well well RB cord-331066-ediowz4s 180 18 as as IN cord-331066-ediowz4s 180 19 the the DT cord-331066-ediowz4s 180 20 windows window NNS cord-331066-ediowz4s 180 21 enriched enrich VBN cord-331066-ediowz4s 180 22 or or CC cord-331066-ediowz4s 180 23 depleted deplete VBN cord-331066-ediowz4s 180 24 by by IN cord-331066-ediowz4s 180 25 the the DT cord-331066-ediowz4s 180 26 motifs motif NNS cord-331066-ediowz4s 180 27 of of IN cord-331066-ediowz4s 180 28 the the DT cord-331066-ediowz4s 180 29 same same JJ cord-331066-ediowz4s 180 30 type type NN cord-331066-ediowz4s 180 31 . . . cord-331066-ediowz4s 181 1 Despite despite IN cord-331066-ediowz4s 181 2 evolutionary evolutionary JJ cord-331066-ediowz4s 181 3 divergence divergence NN cord-331066-ediowz4s 181 4 between between IN cord-331066-ediowz4s 181 5 the the DT cord-331066-ediowz4s 181 6 two two CD cord-331066-ediowz4s 181 7 viruses virus NNS cord-331066-ediowz4s 181 8 and and CC cord-331066-ediowz4s 181 9 the the DT cord-331066-ediowz4s 181 10 action action NN cord-331066-ediowz4s 181 11 of of IN cord-331066-ediowz4s 181 12 point point NN cord-331066-ediowz4s 181 13 mutations mutation NNS cord-331066-ediowz4s 181 14 and and CC cord-331066-ediowz4s 181 15 indels indel NNS cord-331066-ediowz4s 181 16 , , , cord-331066-ediowz4s 181 17 some some DT cord-331066-ediowz4s 181 18 features feature NNS cord-331066-ediowz4s 181 19 appear appear VBP cord-331066-ediowz4s 181 20 to to TO cord-331066-ediowz4s 181 21 be be VB cord-331066-ediowz4s 181 22 remarkably remarkably RB cord-331066-ediowz4s 181 23 reproducible reproducible JJ cord-331066-ediowz4s 181 24 in in IN cord-331066-ediowz4s 181 25 all all DT cord-331066-ediowz4s 181 26 genomes genome NNS cord-331066-ediowz4s 181 27 . . . cord-331066-ediowz4s 182 1 In in IN cord-331066-ediowz4s 182 2 particular particular JJ cord-331066-ediowz4s 182 3 , , , cord-331066-ediowz4s 182 4 in in IN cord-331066-ediowz4s 182 5 the the DT cord-331066-ediowz4s 182 6 window window NN cord-331066-ediowz4s 182 7 # # NN cord-331066-ediowz4s 182 8 3 3 CD cord-331066-ediowz4s 182 9 ( ( -LRB- cord-331066-ediowz4s 182 10 sites site NNS cord-331066-ediowz4s 182 11 865 865 CD cord-331066-ediowz4s 182 12 - - HYPH cord-331066-ediowz4s 182 13 1296 1296 CD cord-331066-ediowz4s 182 14 ) ) -RRB- cord-331066-ediowz4s 182 15 the the DT cord-331066-ediowz4s 182 16 normalized normalize VBN cord-331066-ediowz4s 182 17 NCF NCF NNP cord-331066-ediowz4s 182 18 deviations deviation NNS cord-331066-ediowz4s 182 19 exceeded exceed VBD cord-331066-ediowz4s 182 20 significance significance NN cord-331066-ediowz4s 182 21 threshold threshold NN cord-331066-ediowz4s 182 22 Pr Pr NNP cord-331066-ediowz4s 182 23 ¼ ¼ NNP cord-331066-ediowz4s 182 24 0.05 0.05 CD cord-331066-ediowz4s 182 25 for for IN cord-331066-ediowz4s 182 26 all all DT cord-331066-ediowz4s 182 27 genomes genome NNS cord-331066-ediowz4s 182 28 at at IN cord-331066-ediowz4s 182 29 m m CD cord-331066-ediowz4s 182 30 0 0 CD cord-331066-ediowz4s 182 31 ¼54 ¼54 NNP cord-331066-ediowz4s 182 32 . . . cord-331066-ediowz4s 183 1 Similar similar JJ cord-331066-ediowz4s 183 2 but but CC cord-331066-ediowz4s 183 3 stronger strong JJR cord-331066-ediowz4s 183 4 effects effect NNS cord-331066-ediowz4s 183 5 were be VBD cord-331066-ediowz4s 183 6 observed observe VBN cord-331066-ediowz4s 183 7 for for IN cord-331066-ediowz4s 183 8 the the DT cord-331066-ediowz4s 183 9 window window NN cord-331066-ediowz4s 183 10 # # $ cord-331066-ediowz4s 183 11 5 5 CD cord-331066-ediowz4s 183 12 ( ( -LRB- cord-331066-ediowz4s 183 13 1729 1729 CD cord-331066-ediowz4s 183 14 - - SYM cord-331066-ediowz4s 183 15 2160 2160 CD cord-331066-ediowz4s 183 16 ) ) -RRB- cord-331066-ediowz4s 183 17 ; ; : cord-331066-ediowz4s 183 18 in in IN cord-331066-ediowz4s 183 19 the the DT cord-331066-ediowz4s 183 20 latter latter JJ cord-331066-ediowz4s 183 21 case case NN cord-331066-ediowz4s 183 22 for for IN cord-331066-ediowz4s 183 23 SARS SARS NNP cord-331066-ediowz4s 183 24 - - HYPH cord-331066-ediowz4s 183 25 CoV CoV NNP cord-331066-ediowz4s 183 26 , , , cord-331066-ediowz4s 183 27 this this DT cord-331066-ediowz4s 183 28 window window NN cord-331066-ediowz4s 183 29 was be VBD cord-331066-ediowz4s 183 30 also also RB cord-331066-ediowz4s 183 31 enriched enrich VBN cord-331066-ediowz4s 183 32 by by IN cord-331066-ediowz4s 183 33 the the DT cord-331066-ediowz4s 183 34 motifs motif NNS cord-331066-ediowz4s 183 35 with with IN cord-331066-ediowz4s 183 36 m m NN cord-331066-ediowz4s 183 37 0 0 CD cord-331066-ediowz4s 183 38 ¼87 ¼87 NNP cord-331066-ediowz4s 183 39 . . . cord-331066-ediowz4s 184 1 The the DT cord-331066-ediowz4s 184 2 window window NN cord-331066-ediowz4s 184 3 # # $ cord-331066-ediowz4s 184 4 29 29 CD cord-331066-ediowz4s 184 5 ( ( -LRB- cord-331066-ediowz4s 184 6 12097 12097 CD cord-331066-ediowz4s 184 7 - - SYM cord-331066-ediowz4s 184 8 12528 12528 CD cord-331066-ediowz4s 184 9 ) ) -RRB- cord-331066-ediowz4s 184 10 was be VBD cord-331066-ediowz4s 184 11 enriched enrich VBN cord-331066-ediowz4s 184 12 by by IN cord-331066-ediowz4s 184 13 the the DT cord-331066-ediowz4s 184 14 motifs motif NNS cord-331066-ediowz4s 184 15 with with IN cord-331066-ediowz4s 184 16 m m NN cord-331066-ediowz4s 184 17 0 0 CD cord-331066-ediowz4s 184 18 ¼54 ¼54 NN cord-331066-ediowz4s 184 19 ; ; : cord-331066-ediowz4s 184 20 additionally additionally RB cord-331066-ediowz4s 184 21 , , , cord-331066-ediowz4s 184 22 for for IN cord-331066-ediowz4s 184 23 all all DT cord-331066-ediowz4s 184 24 isolates isolate NNS cord-331066-ediowz4s 184 25 of of IN cord-331066-ediowz4s 184 26 SARS SARS NNP cord-331066-ediowz4s 184 27 - - : cord-331066-ediowz4s 184 28 CoV-2 CoV-2 NNP cord-331066-ediowz4s 184 29 this this DT cord-331066-ediowz4s 184 30 window window NN cord-331066-ediowz4s 184 31 was be VBD cord-331066-ediowz4s 184 32 enriched enrich VBN cord-331066-ediowz4s 184 33 by by IN cord-331066-ediowz4s 184 34 the the DT cord-331066-ediowz4s 184 35 motifs motif NNS cord-331066-ediowz4s 184 36 with with IN cord-331066-ediowz4s 184 37 m m NN cord-331066-ediowz4s 184 38 0 0 CD cord-331066-ediowz4s 184 39 ¼87 ¼87 NNP cord-331066-ediowz4s 184 40 . . . cord-331066-ediowz4s 185 1 An an DT cord-331066-ediowz4s 185 2 opposite opposite JJ cord-331066-ediowz4s 185 3 example example NN cord-331066-ediowz4s 185 4 with with IN cord-331066-ediowz4s 185 5 depletion depletion NN cord-331066-ediowz4s 185 6 of of IN cord-331066-ediowz4s 185 7 motifs motif NNS cord-331066-ediowz4s 185 8 associated associate VBN cord-331066-ediowz4s 185 9 with with IN cord-331066-ediowz4s 185 10 m m NN cord-331066-ediowz4s 185 11 0 0 CD cord-331066-ediowz4s 185 12 ¼87 ¼87 NNP cord-331066-ediowz4s 185 13 can can MD cord-331066-ediowz4s 185 14 be be VB cord-331066-ediowz4s 185 15 seen see VBN cord-331066-ediowz4s 185 16 in in IN cord-331066-ediowz4s 185 17 the the DT cord-331066-ediowz4s 185 18 window window NN cord-331066-ediowz4s 185 19 # # $ cord-331066-ediowz4s 185 20 34 34 CD cord-331066-ediowz4s 186 1 ( ( -LRB- cord-331066-ediowz4s 186 2 14257 14257 CD cord-331066-ediowz4s 186 3 - - SYM cord-331066-ediowz4s 186 4 14688 14688 CD cord-331066-ediowz4s 186 5 ) ) -RRB- cord-331066-ediowz4s 186 6 . . . cord-331066-ediowz4s 187 1 These these DT cord-331066-ediowz4s 187 2 profiles profile NNS cord-331066-ediowz4s 187 3 may may MD cord-331066-ediowz4s 187 4 explain explain VB cord-331066-ediowz4s 187 5 why why WRB cord-331066-ediowz4s 187 6 the the DT cord-331066-ediowz4s 187 7 mean mean JJ cord-331066-ediowz4s 187 8 deviation deviation NN cord-331066-ediowz4s 187 9 with with IN cord-331066-ediowz4s 187 10 m m NN cord-331066-ediowz4s 187 11 0 0 CD cord-331066-ediowz4s 187 12 ¼84 ¼84 NNP cord-331066-ediowz4s 187 13 exceeds exceed VBZ cord-331066-ediowz4s 187 14 the the DT cord-331066-ediowz4s 187 15 deviation deviation NN cord-331066-ediowz4s 187 16 with with IN cord-331066-ediowz4s 187 17 m m NN cord-331066-ediowz4s 187 18 0 0 CD cord-331066-ediowz4s 187 19 ¼87 ¼87 NNP cord-331066-ediowz4s 187 20 in in IN cord-331066-ediowz4s 187 21 the the DT cord-331066-ediowz4s 187 22 genomes genome NNS cord-331066-ediowz4s 187 23 of of IN cord-331066-ediowz4s 187 24 SARS SARS NNP cord-331066-ediowz4s 187 25 - - HYPH cord-331066-ediowz4s 187 26 CoV-2 CoV-2 NNP cord-331066-ediowz4s 187 27 . . . cord-331066-ediowz4s 188 1 In in IN cord-331066-ediowz4s 188 2 the the DT cord-331066-ediowz4s 188 3 latter latter JJ cord-331066-ediowz4s 188 4 case case NN cord-331066-ediowz4s 188 5 , , , cord-331066-ediowz4s 188 6 despite despite IN cord-331066-ediowz4s 188 7 significant significant JJ cord-331066-ediowz4s 188 8 enrichment enrichment NN cord-331066-ediowz4s 188 9 by by IN cord-331066-ediowz4s 188 10 the the DT cord-331066-ediowz4s 188 11 motif motif NN cord-331066-ediowz4s 188 12 with with IN cord-331066-ediowz4s 188 13 m m NN cord-331066-ediowz4s 188 14 0 0 CD cord-331066-ediowz4s 188 15 ¼87 ¼87 NNP cord-331066-ediowz4s 188 16 in in IN cord-331066-ediowz4s 188 17 some some DT cord-331066-ediowz4s 188 18 of of IN cord-331066-ediowz4s 188 19 the the DT cord-331066-ediowz4s 188 20 windows window NNS cord-331066-ediowz4s 188 21 , , , cord-331066-ediowz4s 188 22 there there EX cord-331066-ediowz4s 188 23 are be VBP cord-331066-ediowz4s 188 24 also also RB cord-331066-ediowz4s 188 25 the the DT cord-331066-ediowz4s 188 26 windows window NNS cord-331066-ediowz4s 188 27 with with IN cord-331066-ediowz4s 188 28 significant significant JJ cord-331066-ediowz4s 188 29 depletion depletion NN cord-331066-ediowz4s 188 30 of of IN cord-331066-ediowz4s 188 31 this this DT cord-331066-ediowz4s 188 32 motif motif NN cord-331066-ediowz4s 188 33 . . . cord-331066-ediowz4s 189 1 Similar similar JJ cord-331066-ediowz4s 189 2 profiles profile NNS cord-331066-ediowz4s 189 3 were be VBD cord-331066-ediowz4s 189 4 also also RB cord-331066-ediowz4s 189 5 obtained obtain VBN cord-331066-ediowz4s 189 6 for for IN cord-331066-ediowz4s 189 7 DDFT DDFT NNP cord-331066-ediowz4s 189 8 harmonics harmonic NNS cord-331066-ediowz4s 189 9 with with IN cord-331066-ediowz4s 189 10 the the DT cord-331066-ediowz4s 189 11 spectral spectral JJ cord-331066-ediowz4s 189 12 numbers number NNS cord-331066-ediowz4s 189 13 n n CC cord-331066-ediowz4s 189 14 ' ' POS cord-331066-ediowz4s 189 15 ¼ ¼ NNP cord-331066-ediowz4s 189 16 27 27 CD cord-331066-ediowz4s 189 17 , , , cord-331066-ediowz4s 189 18 42 42 CD cord-331066-ediowz4s 189 19 and and CC cord-331066-ediowz4s 189 20 43 43 CD cord-331066-ediowz4s 189 21 . . . cord-331066-ediowz4s 190 1 DDFT DDFT NNP cord-331066-ediowz4s 190 2 spectra spectra NNP cord-331066-ediowz4s 190 3 in in IN cord-331066-ediowz4s 190 4 windows window NNS cord-331066-ediowz4s 190 5 of of IN cord-331066-ediowz4s 190 6 width width NN cord-331066-ediowz4s 190 7 432 432 CD cord-331066-ediowz4s 190 8 were be VBD cord-331066-ediowz4s 190 9 computed compute VBN cord-331066-ediowz4s 190 10 for for IN cord-331066-ediowz4s 190 11 the the DT cord-331066-ediowz4s 190 12 sum sum NN cord-331066-ediowz4s 190 13 defined define VBN cord-331066-ediowz4s 190 14 by by IN cord-331066-ediowz4s 190 15 Equation equation NN cord-331066-ediowz4s 190 16 ( ( -LRB- cord-331066-ediowz4s 190 17 7 7 CD cord-331066-ediowz4s 190 18 ) ) -RRB- cord-331066-ediowz4s 190 19 as as IN cord-331066-ediowz4s 190 20 described describe VBN cord-331066-ediowz4s 190 21 above above RB cord-331066-ediowz4s 190 22 . . . cord-331066-ediowz4s 191 1 The the DT cord-331066-ediowz4s 191 2 related related JJ cord-331066-ediowz4s 191 3 profiles profile NNS cord-331066-ediowz4s 191 4 can can MD cord-331066-ediowz4s 191 5 be be VB cord-331066-ediowz4s 191 6 found find VBN cord-331066-ediowz4s 191 7 in in IN cord-331066-ediowz4s 191 8 Supporting support VBG cord-331066-ediowz4s 191 9 Information Information NNP cord-331066-ediowz4s 191 10 S2 S2 NNP cord-331066-ediowz4s 191 11 . . . cord-331066-ediowz4s 192 1 The the DT cord-331066-ediowz4s 192 2 counterpart counterpart NN cord-331066-ediowz4s 192 3 profiles profile VBZ cord-331066-ediowz4s 192 4 for for IN cord-331066-ediowz4s 192 5 the the DT cord-331066-ediowz4s 192 6 normalized normalized JJ cord-331066-ediowz4s 192 7 NCF NCF NNP cord-331066-ediowz4s 192 8 deviations deviation NNS cord-331066-ediowz4s 192 9 and and CC cord-331066-ediowz4s 192 10 DDFT DDFT NNP cord-331066-ediowz4s 192 11 harmonics harmonic NNS cord-331066-ediowz4s 192 12 appear appear VBP cord-331066-ediowz4s 192 13 to to TO cord-331066-ediowz4s 192 14 be be VB cord-331066-ediowz4s 192 15 significantly significantly RB cord-331066-ediowz4s 192 16 correlated correlate VBN cord-331066-ediowz4s 192 17 in in IN cord-331066-ediowz4s 192 18 the the DT cord-331066-ediowz4s 192 19 same same JJ cord-331066-ediowz4s 192 20 genomes genome NNS cord-331066-ediowz4s 192 21 . . . cord-331066-ediowz4s 193 1 Therefore therefore RB cord-331066-ediowz4s 193 2 , , , cord-331066-ediowz4s 193 3 the the DT cord-331066-ediowz4s 193 4 characteristic characteristic JJ cord-331066-ediowz4s 193 5 features feature VBZ cord-331066-ediowz4s 193 6 in in IN cord-331066-ediowz4s 193 7 the the DT cord-331066-ediowz4s 193 8 both both DT cord-331066-ediowz4s 193 9 sets set NNS cord-331066-ediowz4s 193 10 of of IN cord-331066-ediowz4s 193 11 profiles profile NNS cord-331066-ediowz4s 193 12 were be VBD cord-331066-ediowz4s 193 13 approximately approximately RB cord-331066-ediowz4s 193 14 reproducible reproducible JJ cord-331066-ediowz4s 193 15 . . . cord-331066-ediowz4s 194 1 In in IN cord-331066-ediowz4s 194 2 addition addition NN cord-331066-ediowz4s 194 3 to to IN cord-331066-ediowz4s 194 4 these these DT cord-331066-ediowz4s 194 5 features feature NNS cord-331066-ediowz4s 194 6 , , , cord-331066-ediowz4s 194 7 an an DT cord-331066-ediowz4s 194 8 extremely extremely RB cord-331066-ediowz4s 194 9 high high JJ cord-331066-ediowz4s 194 10 peak peak NN cord-331066-ediowz4s 194 11 for for IN cord-331066-ediowz4s 194 12 the the DT cord-331066-ediowz4s 194 13 DDFT DDFT NNP cord-331066-ediowz4s 194 14 harmonic harmonic NNP cord-331066-ediowz4s 194 15 with with IN cord-331066-ediowz4s 194 16 n n NNP cord-331066-ediowz4s 194 17 ' ' POS cord-331066-ediowz4s 194 18 ¼ ¼ NNP cord-331066-ediowz4s 194 19 27 27 CD cord-331066-ediowz4s 194 20 , , , cord-331066-ediowz4s 194 21 p p NN cord-331066-ediowz4s 194 22 ' ' POS cord-331066-ediowz4s 194 23 ¼ ¼ NNP cord-331066-ediowz4s 194 24 54.2 54.2 CD cord-331066-ediowz4s 194 25 was be VBD cord-331066-ediowz4s 194 26 observed observe VBN cord-331066-ediowz4s 194 27 in in IN cord-331066-ediowz4s 194 28 the the DT cord-331066-ediowz4s 194 29 window window NN cord-331066-ediowz4s 194 30 # # NN cord-331066-ediowz4s 194 31 60 60 CD cord-331066-ediowz4s 194 32 ( ( -LRB- cord-331066-ediowz4s 194 33 25489 25489 CD cord-331066-ediowz4s 194 34 - - SYM cord-331066-ediowz4s 194 35 25920 25920 CD cord-331066-ediowz4s 194 36 ) ) -RRB- cord-331066-ediowz4s 194 37 in in IN cord-331066-ediowz4s 194 38 the the DT cord-331066-ediowz4s 194 39 genome genome NN cord-331066-ediowz4s 194 40 of of IN cord-331066-ediowz4s 194 41 SARS SARS NNP cord-331066-ediowz4s 194 42 - - HYPH cord-331066-ediowz4s 194 43 CoV. CoV. NNP cord-331066-ediowz4s 194 44 Reconstructed reconstruct VBN cord-331066-ediowz4s 194 45 motifs motif NNS cord-331066-ediowz4s 194 46 and and CC cord-331066-ediowz4s 194 47 their -PRON- PRP$ cord-331066-ediowz4s 194 48 positions position NNS cord-331066-ediowz4s 194 49 on on IN cord-331066-ediowz4s 194 50 the the DT cord-331066-ediowz4s 194 51 genomes genome NNS cord-331066-ediowz4s 194 52 were be VBD cord-331066-ediowz4s 194 53 obtained obtain VBN cord-331066-ediowz4s 194 54 by by IN cord-331066-ediowz4s 194 55 TAMGI TAMGI NNP cord-331066-ediowz4s 194 56 with with IN cord-331066-ediowz4s 194 57 the the DT cord-331066-ediowz4s 194 58 steps step NNS cord-331066-ediowz4s 194 59 s s POS cord-331066-ediowz4s 194 60 ¼ ¼ NNP cord-331066-ediowz4s 194 61 54 54 CD cord-331066-ediowz4s 194 62 , , , cord-331066-ediowz4s 194 63 84 84 CD cord-331066-ediowz4s 194 64 and and CC cord-331066-ediowz4s 194 65 87 87 CD cord-331066-ediowz4s 194 66 . . . cord-331066-ediowz4s 195 1 The the DT cord-331066-ediowz4s 195 2 resulting result VBG cord-331066-ediowz4s 195 3 sequences sequence NNS cord-331066-ediowz4s 195 4 after after IN cord-331066-ediowz4s 195 5 TAMGI TAMGI NNP cord-331066-ediowz4s 195 6 are be VBP cord-331066-ediowz4s 195 7 explicitly explicitly RB cord-331066-ediowz4s 195 8 reproduced reproduce VBN cord-331066-ediowz4s 195 9 in in IN cord-331066-ediowz4s 195 10 Supporting support VBG cord-331066-ediowz4s 195 11 Information Information NNP cord-331066-ediowz4s 195 12 S3-S6 S3-S6 NNP cord-331066-ediowz4s 195 13 . . . cord-331066-ediowz4s 196 1 The the DT cord-331066-ediowz4s 196 2 data datum NNS cord-331066-ediowz4s 196 3 on on IN cord-331066-ediowz4s 196 4 the the DT cord-331066-ediowz4s 196 5 total total JJ cord-331066-ediowz4s 196 6 fractions fraction NNS cord-331066-ediowz4s 196 7 of of IN cord-331066-ediowz4s 196 8 nucleotides nucleotide NNS cord-331066-ediowz4s 196 9 after after IN cord-331066-ediowz4s 196 10 TAMGI TAMGI NNP cord-331066-ediowz4s 196 11 are be VBP cord-331066-ediowz4s 196 12 summarized summarize VBN cord-331066-ediowz4s 196 13 in in IN cord-331066-ediowz4s 196 14 Table Table NNP cord-331066-ediowz4s 196 15 1 1 CD cord-331066-ediowz4s 196 16 . . . cord-331066-ediowz4s 197 1 A a DT cord-331066-ediowz4s 197 2 simple simple JJ cord-331066-ediowz4s 197 3 theoretical theoretical JJ cord-331066-ediowz4s 197 4 consideration consideration NN cord-331066-ediowz4s 197 5 shows show VBZ cord-331066-ediowz4s 197 6 that that IN cord-331066-ediowz4s 197 7 the the DT cord-331066-ediowz4s 197 8 partial partial JJ cord-331066-ediowz4s 197 9 fractions fraction NNS cord-331066-ediowz4s 197 10 of of IN cord-331066-ediowz4s 197 11 nucleotides nucleotide NNS cord-331066-ediowz4s 197 12 after after IN cord-331066-ediowz4s 197 13 TAMGI TAMGI NNS cord-331066-ediowz4s 197 14 for for IN cord-331066-ediowz4s 197 15 the the DT cord-331066-ediowz4s 197 16 randomly randomly RB cord-331066-ediowz4s 197 17 reshuffled reshuffle VBN cord-331066-ediowz4s 197 18 genomic genomic JJ cord-331066-ediowz4s 197 19 sequences sequence NNS cord-331066-ediowz4s 197 20 are be VBP cord-331066-ediowz4s 197 21 given give VBN cord-331066-ediowz4s 197 22 by by IN cord-331066-ediowz4s 197 23 where where WRB cord-331066-ediowz4s 197 24 / / SYM cord-331066-ediowz4s 197 25 a a DT cord-331066-ediowz4s 197 26 is be VBZ cord-331066-ediowz4s 197 27 the the DT cord-331066-ediowz4s 197 28 frequency frequency NN cord-331066-ediowz4s 197 29 of of IN cord-331066-ediowz4s 197 30 nucleotides nucleotide NNS cord-331066-ediowz4s 197 31 of of IN cord-331066-ediowz4s 197 32 the the DT cord-331066-ediowz4s 197 33 type type NN cord-331066-ediowz4s 198 1 a a DT cord-331066-ediowz4s 198 2 retained retain VBN cord-331066-ediowz4s 198 3 under under IN cord-331066-ediowz4s 198 4 reshuffling reshuffling NN cord-331066-ediowz4s 198 5 . . . cord-331066-ediowz4s 199 1 Equation equation NN cord-331066-ediowz4s 199 2 ( ( -LRB- cord-331066-ediowz4s 199 3 33 33 CD cord-331066-ediowz4s 199 4 ) ) -RRB- cord-331066-ediowz4s 199 5 was be VBD cord-331066-ediowz4s 199 6 additionally additionally RB cord-331066-ediowz4s 199 7 verified verify VBN cord-331066-ediowz4s 199 8 by by IN cord-331066-ediowz4s 199 9 simulations simulation NNS cord-331066-ediowz4s 199 10 . . . cord-331066-ediowz4s 200 1 The the DT cord-331066-ediowz4s 200 2 frequencies frequency NNS cord-331066-ediowz4s 200 3 given give VBN cord-331066-ediowz4s 200 4 by by IN cord-331066-ediowz4s 200 5 Equation equation NN cord-331066-ediowz4s 200 6 ( ( -LRB- cord-331066-ediowz4s 200 7 33 33 CD cord-331066-ediowz4s 200 8 ) ) -RRB- cord-331066-ediowz4s 200 9 are be VBP cord-331066-ediowz4s 200 10 independent independent JJ cord-331066-ediowz4s 200 11 of of IN cord-331066-ediowz4s 200 12 steps step NNS cord-331066-ediowz4s 200 13 and and CC cord-331066-ediowz4s 200 14 also also RB cord-331066-ediowz4s 200 15 are be VBP cord-331066-ediowz4s 200 16 reproduced reproduce VBN cord-331066-ediowz4s 200 17 in in IN cord-331066-ediowz4s 200 18 Table Table NNP cord-331066-ediowz4s 200 19 1 1 CD cord-331066-ediowz4s 200 20 for for IN cord-331066-ediowz4s 200 21 reference reference NN cord-331066-ediowz4s 200 22 . . . cord-331066-ediowz4s 201 1 The the DT cord-331066-ediowz4s 201 2 variances variance NNS cord-331066-ediowz4s 201 3 of of IN cord-331066-ediowz4s 201 4 frequencies frequency NNS cord-331066-ediowz4s 201 5 related relate VBN cord-331066-ediowz4s 201 6 to to IN cord-331066-ediowz4s 201 7 particular particular JJ cord-331066-ediowz4s 201 8 random random JJ cord-331066-ediowz4s 201 9 realizations realization NNS cord-331066-ediowz4s 201 10 are be VBP cord-331066-ediowz4s 201 11 about about RB cord-331066-ediowz4s 201 12 r r LS cord-331066-ediowz4s 201 13 2 2 CD cord-331066-ediowz4s 201 14 ðU ðu CD cord-331066-ediowz4s 201 15 a a DT cord-331066-ediowz4s 201 16 Þ þ NN cord-331066-ediowz4s 201 17 ¼ ¼ NN cord-331066-ediowz4s 201 18 U u NN cord-331066-ediowz4s 202 1 a a DT cord-331066-ediowz4s 202 2 ð1ÀU ð1ÀU NNP cord-331066-ediowz4s 203 1 a a DT cord-331066-ediowz4s 203 2 Þ þ NN cord-331066-ediowz4s 203 3 = = SYM cord-331066-ediowz4s 203 4 M m NN cord-331066-ediowz4s 203 5 ; ; : cord-331066-ediowz4s 203 6 r r NNP cord-331066-ediowz4s 203 7 2 2 CD cord-331066-ediowz4s 203 8 total total NN cord-331066-ediowz4s 203 9 ¼ ¼ NNP cord-331066-ediowz4s 203 10 X x NN cord-331066-ediowz4s 203 11 a a DT cord-331066-ediowz4s 203 12 r r NN cord-331066-ediowz4s 203 13 2 2 CD cord-331066-ediowz4s 203 14 ðU ðu CD cord-331066-ediowz4s 203 15 a a DT cord-331066-ediowz4s 203 16 Þ þ NN cord-331066-ediowz4s 203 17 : : : cord-331066-ediowz4s 203 18 Equation equation NN cord-331066-ediowz4s 203 19 ( ( -LRB- cord-331066-ediowz4s 203 20 34 34 CD cord-331066-ediowz4s 203 21 ) ) -RRB- cord-331066-ediowz4s 204 1 yields yield NNS cord-331066-ediowz4s 204 2 for for IN cord-331066-ediowz4s 204 3 r r NNP cord-331066-ediowz4s 204 4 total total VBP cord-331066-ediowz4s 204 5 the the DT cord-331066-ediowz4s 204 6 value value NN cord-331066-ediowz4s 204 7 of of IN cord-331066-ediowz4s 204 8 0.004 0.004 CD cord-331066-ediowz4s 204 9 that that WDT cord-331066-ediowz4s 204 10 is be VBZ cord-331066-ediowz4s 204 11 much much RB cord-331066-ediowz4s 204 12 lower low JJR cord-331066-ediowz4s 204 13 than than IN cord-331066-ediowz4s 204 14 the the DT cord-331066-ediowz4s 204 15 differences difference NNS cord-331066-ediowz4s 204 16 between between IN cord-331066-ediowz4s 204 17 frequencies frequency NNS cord-331066-ediowz4s 204 18 for for IN cord-331066-ediowz4s 204 19 viral viral JJ cord-331066-ediowz4s 204 20 and and CC cord-331066-ediowz4s 204 21 random random JJ cord-331066-ediowz4s 204 22 sequences sequence NNS cord-331066-ediowz4s 204 23 . . . cord-331066-ediowz4s 205 1 In in IN cord-331066-ediowz4s 205 2 this this DT cord-331066-ediowz4s 205 3 sense sense NN cord-331066-ediowz4s 205 4 , , , cord-331066-ediowz4s 205 5 Table table NN cord-331066-ediowz4s 205 6 1 1 CD cord-331066-ediowz4s 205 7 reveals reveal VBZ cord-331066-ediowz4s 205 8 distinctly distinctly RB cord-331066-ediowz4s 205 9 nonrandom nonrandom JJ cord-331066-ediowz4s 205 10 character character NN cord-331066-ediowz4s 205 11 of of IN cord-331066-ediowz4s 205 12 the the DT cord-331066-ediowz4s 205 13 variations variation NNS cord-331066-ediowz4s 205 14 related relate VBN cord-331066-ediowz4s 205 15 to to IN cord-331066-ediowz4s 205 16 the the DT cord-331066-ediowz4s 205 17 detected detect VBN cord-331066-ediowz4s 205 18 quasi quasi JJ cord-331066-ediowz4s 205 19 - - JJ cord-331066-ediowz4s 205 20 periodic periodic JJ cord-331066-ediowz4s 205 21 patterns pattern NNS cord-331066-ediowz4s 205 22 in in IN cord-331066-ediowz4s 205 23 the the DT cord-331066-ediowz4s 205 24 viral viral JJ cord-331066-ediowz4s 205 25 genomes genome NNS cord-331066-ediowz4s 205 26 . . . cord-331066-ediowz4s 206 1 The the DT cord-331066-ediowz4s 206 2 mutual mutual JJ cord-331066-ediowz4s 206 3 comparison comparison NN cord-331066-ediowz4s 206 4 of of IN cord-331066-ediowz4s 206 5 the the DT cord-331066-ediowz4s 206 6 total total JJ cord-331066-ediowz4s 206 7 frequencies frequency NNS cord-331066-ediowz4s 206 8 of of IN cord-331066-ediowz4s 206 9 nucleotides nucleotide NNS cord-331066-ediowz4s 206 10 after after IN cord-331066-ediowz4s 206 11 TAMGI TAMGI NNS cord-331066-ediowz4s 206 12 for for IN cord-331066-ediowz4s 206 13 the the DT cord-331066-ediowz4s 206 14 different different JJ cord-331066-ediowz4s 206 15 isolates isolate NNS cord-331066-ediowz4s 206 16 of of IN cord-331066-ediowz4s 206 17 SARS SARS NNP cord-331066-ediowz4s 206 18 - - HYPH cord-331066-ediowz4s 206 19 CoV-2 CoV-2 NNP cord-331066-ediowz4s 206 20 shows show VBZ cord-331066-ediowz4s 206 21 their -PRON- PRP$ cord-331066-ediowz4s 206 22 robustness robustness NN cord-331066-ediowz4s 206 23 against against IN cord-331066-ediowz4s 206 24 point point NN cord-331066-ediowz4s 206 25 mutations mutation NNS cord-331066-ediowz4s 206 26 and and CC cord-331066-ediowz4s 206 27 indels indel NNS cord-331066-ediowz4s 206 28 . . . cord-331066-ediowz4s 207 1 The the DT cord-331066-ediowz4s 207 2 general general JJ cord-331066-ediowz4s 207 3 distributions distribution NNS cord-331066-ediowz4s 207 4 of of IN cord-331066-ediowz4s 207 5 k k NNP cord-331066-ediowz4s 207 6 - - HYPH cord-331066-ediowz4s 207 7 mers mers NNP cord-331066-ediowz4s 207 8 , , , cord-331066-ediowz4s 207 9 -N -N : cord-331066-ediowz4s 207 10 k k XX cord-331066-ediowz4s 207 11 - - HYPH cord-331066-ediowz4s 207 12 , , , cord-331066-ediowz4s 207 13 on on IN cord-331066-ediowz4s 207 14 the the DT cord-331066-ediowz4s 207 15 length length NN cord-331066-ediowz4s 207 16 k k NNP cord-331066-ediowz4s 207 17 are be VBP cord-331066-ediowz4s 207 18 presented present VBN cord-331066-ediowz4s 207 19 in in IN cord-331066-ediowz4s 207 20 Table Table NNP cord-331066-ediowz4s 207 21 2 2 CD cord-331066-ediowz4s 207 22 . . . cord-331066-ediowz4s 208 1 The the DT cord-331066-ediowz4s 208 2 period period NN cord-331066-ediowz4s 208 3 of of IN cord-331066-ediowz4s 208 4 p p CD cord-331066-ediowz4s 208 5 % % NN cord-331066-ediowz4s 208 6 54 54 CD cord-331066-ediowz4s 208 7 implies imply VBZ cord-331066-ediowz4s 208 8 the the DT cord-331066-ediowz4s 208 9 association association NN cord-331066-ediowz4s 208 10 of of IN cord-331066-ediowz4s 208 11 6.75 6.75 CD cord-331066-ediowz4s 208 12 nt nt RB cord-331066-ediowz4s 208 13 per per IN cord-331066-ediowz4s 208 14 one one CD cord-331066-ediowz4s 208 15 N n CD cord-331066-ediowz4s 208 16 protein protein NN cord-331066-ediowz4s 208 17 ( ( -LRB- cord-331066-ediowz4s 208 18 see see VB cord-331066-ediowz4s 208 19 Subsection subsection NN cord-331066-ediowz4s 208 20 4.2 4.2 CD cord-331066-ediowz4s 208 21 below below RB cord-331066-ediowz4s 208 22 ) ) -RRB- cord-331066-ediowz4s 208 23 . . . cord-331066-ediowz4s 209 1 All all DT cord-331066-ediowz4s 209 2 motifs motif NNS cord-331066-ediowz4s 209 3 with with IN cord-331066-ediowz4s 209 4 k k NNP cord-331066-ediowz4s 209 5 ! ! NNP cord-331066-ediowz4s 209 6 6 6 CD cord-331066-ediowz4s 209 7 and and CC cord-331066-ediowz4s 209 8 their -PRON- PRP$ cord-331066-ediowz4s 209 9 positions position NNS cord-331066-ediowz4s 209 10 on on IN cord-331066-ediowz4s 209 11 the the DT cord-331066-ediowz4s 209 12 genomes genome NNS cord-331066-ediowz4s 209 13 are be VBP cord-331066-ediowz4s 209 14 enumerated enumerate VBN cord-331066-ediowz4s 209 15 in in IN cord-331066-ediowz4s 209 16 Supporting support VBG cord-331066-ediowz4s 209 17 Information Information NNP cord-331066-ediowz4s 209 18 S7 S7 NNP cord-331066-ediowz4s 209 19 . . . cord-331066-ediowz4s 210 1 The the DT cord-331066-ediowz4s 210 2 profiles profile NNS cord-331066-ediowz4s 210 3 for for IN cord-331066-ediowz4s 210 4 the the DT cord-331066-ediowz4s 210 5 total total JJ cord-331066-ediowz4s 210 6 numbers number NNS cord-331066-ediowz4s 210 7 of of IN cord-331066-ediowz4s 210 8 nucleotides nucleotide NNS cord-331066-ediowz4s 210 9 within within IN cord-331066-ediowz4s 210 10 nonoverlapping nonoverlappe VBG cord-331066-ediowz4s 210 11 windows window NNS cord-331066-ediowz4s 210 12 of of IN cord-331066-ediowz4s 210 13 width width NN cord-331066-ediowz4s 210 14 432 432 CD cord-331066-ediowz4s 210 15 nt nt RB cord-331066-ediowz4s 210 16 after after IN cord-331066-ediowz4s 210 17 TAMGI TAMGI NNP cord-331066-ediowz4s 210 18 with with IN cord-331066-ediowz4s 210 19 the the DT cord-331066-ediowz4s 210 20 steps step NNS cord-331066-ediowz4s 210 21 s s POS cord-331066-ediowz4s 210 22 ¼ ¼ NNP cord-331066-ediowz4s 210 23 54 54 CD cord-331066-ediowz4s 210 24 , , , cord-331066-ediowz4s 210 25 84 84 CD cord-331066-ediowz4s 210 26 and and CC cord-331066-ediowz4s 210 27 87 87 CD cord-331066-ediowz4s 210 28 are be VBP cord-331066-ediowz4s 210 29 shown show VBN cord-331066-ediowz4s 210 30 in in IN cord-331066-ediowz4s 210 31 Figure Figure NNP cord-331066-ediowz4s 210 32 6 6 CD cord-331066-ediowz4s 210 33 . . . cord-331066-ediowz4s 211 1 For for IN cord-331066-ediowz4s 211 2 the the DT cord-331066-ediowz4s 211 3 incomplete incomplete JJ cord-331066-ediowz4s 211 4 windows window NNS cord-331066-ediowz4s 211 5 # # $ cord-331066-ediowz4s 211 6 69 69 CD cord-331066-ediowz4s 211 7 these these DT cord-331066-ediowz4s 211 8 numbers number NNS cord-331066-ediowz4s 211 9 were be VBD cord-331066-ediowz4s 211 10 increased increase VBN cord-331066-ediowz4s 211 11 proportionally proportionally RB cord-331066-ediowz4s 211 12 to to TO cord-331066-ediowz4s 211 13 obtain obtain VB cord-331066-ediowz4s 211 14 estimates estimate NNS cord-331066-ediowz4s 211 15 for for IN cord-331066-ediowz4s 211 16 the the DT cord-331066-ediowz4s 211 17 width width NN cord-331066-ediowz4s 211 18 of of IN cord-331066-ediowz4s 211 19 432 432 CD cord-331066-ediowz4s 211 20 nt nt RB cord-331066-ediowz4s 211 21 . . . cord-331066-ediowz4s 212 1 The the DT cord-331066-ediowz4s 212 2 profiles profile NNS cord-331066-ediowz4s 212 3 in in IN cord-331066-ediowz4s 212 4 Figures figure NNS cord-331066-ediowz4s 212 5 5 5 CD cord-331066-ediowz4s 212 6 and and CC cord-331066-ediowz4s 212 7 6 6 CD cord-331066-ediowz4s 212 8 are be VBP cord-331066-ediowz4s 212 9 close close JJ cord-331066-ediowz4s 212 10 but but CC cord-331066-ediowz4s 212 11 differ differ VBP cord-331066-ediowz4s 212 12 in in IN cord-331066-ediowz4s 212 13 some some DT cord-331066-ediowz4s 212 14 features feature NNS cord-331066-ediowz4s 212 15 . . . cord-331066-ediowz4s 213 1 The the DT cord-331066-ediowz4s 213 2 corresponding correspond VBG cord-331066-ediowz4s 213 3 Pearson Pearson NNP cord-331066-ediowz4s 213 4 correlation correlation NN cord-331066-ediowz4s 213 5 coefficients coefficient NNS cord-331066-ediowz4s 213 6 between between IN cord-331066-ediowz4s 213 7 the the DT cord-331066-ediowz4s 213 8 counterpart counterpart NN cord-331066-ediowz4s 213 9 profiles profile NNS cord-331066-ediowz4s 213 10 in in IN cord-331066-ediowz4s 213 11 Figures figure NNS cord-331066-ediowz4s 213 12 5 5 CD cord-331066-ediowz4s 213 13 and and CC cord-331066-ediowz4s 213 14 6 6 CD cord-331066-ediowz4s 213 15 were be VBD cord-331066-ediowz4s 213 16 highly highly RB cord-331066-ediowz4s 213 17 significant significant JJ cord-331066-ediowz4s 213 18 , , , cord-331066-ediowz4s 213 19 0.72 0.72 CD cord-331066-ediowz4s 213 20 - - SYM cord-331066-ediowz4s 213 21 0.86 0.86 CD cord-331066-ediowz4s 213 22 . . . cord-331066-ediowz4s 214 1 Nevertheless nevertheless RB cord-331066-ediowz4s 214 2 , , , cord-331066-ediowz4s 214 3 the the DT cord-331066-ediowz4s 214 4 highest high JJS cord-331066-ediowz4s 214 5 peaks peak NNS cord-331066-ediowz4s 214 6 and and CC cord-331066-ediowz4s 214 7 the the DT cord-331066-ediowz4s 214 8 lowest low JJS cord-331066-ediowz4s 214 9 troughs trough NNS cord-331066-ediowz4s 214 10 may may MD cord-331066-ediowz4s 214 11 differ differ VB cord-331066-ediowz4s 214 12 between between IN cord-331066-ediowz4s 214 13 the the DT cord-331066-ediowz4s 214 14 counterpart counterpart NN cord-331066-ediowz4s 214 15 profiles profile NNS cord-331066-ediowz4s 214 16 . . . cord-331066-ediowz4s 215 1 In in IN cord-331066-ediowz4s 215 2 particular particular JJ cord-331066-ediowz4s 215 3 , , , cord-331066-ediowz4s 215 4 the the DT cord-331066-ediowz4s 215 5 highest high JJS cord-331066-ediowz4s 215 6 peak peak NN cord-331066-ediowz4s 215 7 in in IN cord-331066-ediowz4s 215 8 Figure figure NN cord-331066-ediowz4s 215 9 6 6 CD cord-331066-ediowz4s 215 10 ( ( -LRB- cord-331066-ediowz4s 215 11 A a NN cord-331066-ediowz4s 215 12 ) ) -RRB- cord-331066-ediowz4s 215 13 was be VBD cord-331066-ediowz4s 215 14 observed observe VBN cord-331066-ediowz4s 215 15 for for IN cord-331066-ediowz4s 215 16 the the DT cord-331066-ediowz4s 215 17 window window NN cord-331066-ediowz4s 215 18 # # NN cord-331066-ediowz4s 215 19 8 8 CD cord-331066-ediowz4s 215 20 ( ( -LRB- cord-331066-ediowz4s 215 21 sites site NNS cord-331066-ediowz4s 215 22 3025 3025 CD cord-331066-ediowz4s 215 23 - - HYPH cord-331066-ediowz4s 215 24 3456 3456 CD cord-331066-ediowz4s 215 25 ) ) -RRB- cord-331066-ediowz4s 215 26 . . . cord-331066-ediowz4s 216 1 The the DT cord-331066-ediowz4s 216 2 profiles profile NNS cord-331066-ediowz4s 216 3 for for IN cord-331066-ediowz4s 216 4 s s NNP cord-331066-ediowz4s 216 5 ¼ ¼ NNP cord-331066-ediowz4s 216 6 54 54 CD cord-331066-ediowz4s 216 7 and and CC cord-331066-ediowz4s 216 8 87 87 CD cord-331066-ediowz4s 216 9 were be VBD cord-331066-ediowz4s 216 10 slightly slightly RB cord-331066-ediowz4s 216 11 biased biased JJ cord-331066-ediowz4s 216 12 from from IN cord-331066-ediowz4s 216 13 the the DT cord-331066-ediowz4s 216 14 higher high JJR cord-331066-ediowz4s 216 15 values value NNS cord-331066-ediowz4s 216 16 at at IN cord-331066-ediowz4s 216 17 5 5 CD cord-331066-ediowz4s 216 18 0 0 CD cord-331066-ediowz4s 216 19 -end -end : cord-331066-ediowz4s 216 20 to to IN cord-331066-ediowz4s 216 21 the the DT cord-331066-ediowz4s 216 22 lower low JJR cord-331066-ediowz4s 216 23 values value NNS cord-331066-ediowz4s 216 24 at at IN cord-331066-ediowz4s 216 25 3 3 CD cord-331066-ediowz4s 216 26 0 0 CD cord-331066-ediowz4s 216 27 -end -end : cord-331066-ediowz4s 216 28 , , , cord-331066-ediowz4s 216 29 although although IN cord-331066-ediowz4s 216 30 , , , cord-331066-ediowz4s 216 31 the the DT cord-331066-ediowz4s 216 32 extreme extreme JJ cord-331066-ediowz4s 216 33 windows window NNS cord-331066-ediowz4s 216 34 # # $ cord-331066-ediowz4s 216 35 1 1 CD cord-331066-ediowz4s 216 36 ( ( -LRB- cord-331066-ediowz4s 216 37 1 1 CD cord-331066-ediowz4s 216 38 - - SYM cord-331066-ediowz4s 216 39 432 432 CD cord-331066-ediowz4s 216 40 ) ) -RRB- cord-331066-ediowz4s 216 41 comprising comprise VBG cord-331066-ediowz4s 216 42 5 5 CD cord-331066-ediowz4s 216 43 0 0 CD cord-331066-ediowz4s 216 44 -UTR -UTR : cord-331066-ediowz4s 216 45 were be VBD cord-331066-ediowz4s 216 46 depleted deplete VBN cord-331066-ediowz4s 216 47 of of IN cord-331066-ediowz4s 216 48 motifs motif NNS cord-331066-ediowz4s 216 49 . . . cord-331066-ediowz4s 217 1 The the DT cord-331066-ediowz4s 217 2 numerical numerical JJ cord-331066-ediowz4s 217 3 values value NNS cord-331066-ediowz4s 217 4 for for IN cord-331066-ediowz4s 217 5 all all DT cord-331066-ediowz4s 217 6 profiles profile NNS cord-331066-ediowz4s 217 7 in in IN cord-331066-ediowz4s 217 8 Figure figure NN cord-331066-ediowz4s 217 9 6 6 CD cord-331066-ediowz4s 217 10 can can MD cord-331066-ediowz4s 217 11 be be VB cord-331066-ediowz4s 217 12 found find VBN cord-331066-ediowz4s 217 13 in in IN cord-331066-ediowz4s 217 14 Supporting support VBG cord-331066-ediowz4s 217 15 Information Information NNP cord-331066-ediowz4s 217 16 S7 S7 NNP cord-331066-ediowz4s 217 17 . . . cord-331066-ediowz4s 218 1 The the DT cord-331066-ediowz4s 218 2 comparison comparison NN cord-331066-ediowz4s 218 3 of of IN cord-331066-ediowz4s 218 4 repertoires repertoire NNS cord-331066-ediowz4s 218 5 of of IN cord-331066-ediowz4s 218 6 motifs motif NNS cord-331066-ediowz4s 218 7 with with IN cord-331066-ediowz4s 218 8 k k NNP cord-331066-ediowz4s 218 9 ! ! NNP cord-331066-ediowz4s 218 10 6 6 CD cord-331066-ediowz4s 218 11 presented present VBN cord-331066-ediowz4s 218 12 in in IN cord-331066-ediowz4s 218 13 Supporting support VBG cord-331066-ediowz4s 218 14 Information Information NNP cord-331066-ediowz4s 218 15 S7 S7 NNP cord-331066-ediowz4s 218 16 revealed reveal VBD cord-331066-ediowz4s 218 17 nearly nearly RB cord-331066-ediowz4s 218 18 complete complete JJ cord-331066-ediowz4s 218 19 correspondence correspondence NN cord-331066-ediowz4s 218 20 ( ( -LRB- cord-331066-ediowz4s 218 21 up up IN cord-331066-ediowz4s 218 22 to to IN cord-331066-ediowz4s 218 23 one one CD cord-331066-ediowz4s 218 24 - - HYPH cord-331066-ediowz4s 218 25 two two CD cord-331066-ediowz4s 218 26 motifs motif NNS cord-331066-ediowz4s 218 27 ) ) -RRB- cord-331066-ediowz4s 218 28 between between IN cord-331066-ediowz4s 218 29 motifs motif NNS cord-331066-ediowz4s 218 30 for for IN cord-331066-ediowz4s 218 31 three three CD cord-331066-ediowz4s 218 32 isolates isolate NNS cord-331066-ediowz4s 218 33 of of IN cord-331066-ediowz4s 218 34 SARS SARS NNP cord-331066-ediowz4s 218 35 - - HYPH cord-331066-ediowz4s 218 36 CoV-2 CoV-2 NNP cord-331066-ediowz4s 218 37 . . . cord-331066-ediowz4s 219 1 The the DT cord-331066-ediowz4s 219 2 divergence divergence NN cord-331066-ediowz4s 219 3 between between IN cord-331066-ediowz4s 219 4 motifs motif NNS cord-331066-ediowz4s 219 5 for for IN cord-331066-ediowz4s 219 6 SARS SARS NNP cord-331066-ediowz4s 219 7 - - HYPH cord-331066-ediowz4s 219 8 CoV CoV NNP cord-331066-ediowz4s 219 9 and and CC cord-331066-ediowz4s 219 10 SARS SARS NNP cord-331066-ediowz4s 219 11 - - HYPH cord-331066-ediowz4s 219 12 CoV-2 CoV-2 NNP cord-331066-ediowz4s 219 13 appeared appear VBD cord-331066-ediowz4s 219 14 to to TO cord-331066-ediowz4s 219 15 be be VB cord-331066-ediowz4s 219 16 more more RBR cord-331066-ediowz4s 219 17 significant significant JJ cord-331066-ediowz4s 219 18 . . . cord-331066-ediowz4s 220 1 In in IN cord-331066-ediowz4s 220 2 particular particular JJ cord-331066-ediowz4s 220 3 at at IN cord-331066-ediowz4s 220 4 the the DT cord-331066-ediowz4s 220 5 step step NN cord-331066-ediowz4s 220 6 s s NNP cord-331066-ediowz4s 220 7 ¼ ¼ NNP cord-331066-ediowz4s 220 8 54 54 CD cord-331066-ediowz4s 220 9 , , , cord-331066-ediowz4s 220 10 only only RB cord-331066-ediowz4s 220 11 22 22 CD cord-331066-ediowz4s 220 12 hexamer hexamer NN cord-331066-ediowz4s 220 13 motifs motif NNS cord-331066-ediowz4s 220 14 from from IN cord-331066-ediowz4s 220 15 102 102 CD cord-331066-ediowz4s 220 16 different different JJ cord-331066-ediowz4s 220 17 motifs motif NNS cord-331066-ediowz4s 220 18 ( ( -LRB- cord-331066-ediowz4s 220 19 106 106 CD cord-331066-ediowz4s 220 20 in in IN cord-331066-ediowz4s 220 21 total total NN cord-331066-ediowz4s 220 22 ) ) -RRB- cord-331066-ediowz4s 220 23 in in IN cord-331066-ediowz4s 220 24 the the DT cord-331066-ediowz4s 220 25 SARS SARS NNP cord-331066-ediowz4s 220 26 - - HYPH cord-331066-ediowz4s 220 27 CoV CoV NNP cord-331066-ediowz4s 220 28 genome genome NN cord-331066-ediowz4s 220 29 coincided coincide VBD cord-331066-ediowz4s 220 30 with with IN cord-331066-ediowz4s 220 31 those those DT cord-331066-ediowz4s 220 32 for for IN cord-331066-ediowz4s 220 33 SARS SARS NNP cord-331066-ediowz4s 220 34 - - HYPH cord-331066-ediowz4s 220 35 CoV-2 CoV-2 NNP cord-331066-ediowz4s 220 36 and and CC cord-331066-ediowz4s 220 37 36 36 CD cord-331066-ediowz4s 220 38 hexamers hexamer NNS cord-331066-ediowz4s 220 39 differed differ VBN cord-331066-ediowz4s 220 40 by by IN cord-331066-ediowz4s 220 41 one one CD cord-331066-ediowz4s 220 42 letter letter NN cord-331066-ediowz4s 220 43 from from IN cord-331066-ediowz4s 220 44 the the DT cord-331066-ediowz4s 220 45 repertoires repertoire NNS cord-331066-ediowz4s 220 46 of of IN cord-331066-ediowz4s 220 47 hexamers hexamer NNS cord-331066-ediowz4s 220 48 for for IN cord-331066-ediowz4s 220 49 SARS SARS NNP cord-331066-ediowz4s 220 50 - - HYPH cord-331066-ediowz4s 220 51 CoV-2 CoV-2 NNP cord-331066-ediowz4s 220 52 . . . cord-331066-ediowz4s 221 1 The the DT cord-331066-ediowz4s 221 2 similar similar JJ cord-331066-ediowz4s 221 3 comparison comparison NN cord-331066-ediowz4s 221 4 for for IN cord-331066-ediowz4s 221 5 the the DT cord-331066-ediowz4s 221 6 other other JJ cord-331066-ediowz4s 221 7 steps step NNS cord-331066-ediowz4s 221 8 yielded yield VBD cord-331066-ediowz4s 221 9 the the DT cord-331066-ediowz4s 221 10 coincidence coincidence NN cord-331066-ediowz4s 221 11 of of IN cord-331066-ediowz4s 221 12 18 18 CD cord-331066-ediowz4s 221 13 from from IN cord-331066-ediowz4s 221 14 89 89 CD cord-331066-ediowz4s 221 15 different different JJ cord-331066-ediowz4s 221 16 motifs motif NNS cord-331066-ediowz4s 221 17 ( ( -LRB- cord-331066-ediowz4s 221 18 93 93 CD cord-331066-ediowz4s 221 19 in in IN cord-331066-ediowz4s 221 20 total total NN cord-331066-ediowz4s 221 21 ) ) -RRB- cord-331066-ediowz4s 221 22 and and CC cord-331066-ediowz4s 221 23 38 38 CD cord-331066-ediowz4s 221 24 motifs motif NNS cord-331066-ediowz4s 221 25 differing differ VBG cord-331066-ediowz4s 221 26 by by IN cord-331066-ediowz4s 221 27 one one CD cord-331066-ediowz4s 221 28 letter letter NN cord-331066-ediowz4s 221 29 at at IN cord-331066-ediowz4s 221 30 s s NNP cord-331066-ediowz4s 221 31 ¼ ¼ NNP cord-331066-ediowz4s 221 32 84 84 CD cord-331066-ediowz4s 221 33 and and CC cord-331066-ediowz4s 221 34 the the DT cord-331066-ediowz4s 221 35 coincidence coincidence NN cord-331066-ediowz4s 221 36 of of IN cord-331066-ediowz4s 221 37 15 15 CD cord-331066-ediowz4s 221 38 from from IN cord-331066-ediowz4s 221 39 93 93 CD cord-331066-ediowz4s 221 40 different different JJ cord-331066-ediowz4s 221 41 motifs motif NNS cord-331066-ediowz4s 221 42 ( ( -LRB- cord-331066-ediowz4s 221 43 102 102 CD cord-331066-ediowz4s 221 44 in in IN cord-331066-ediowz4s 221 45 total total NN cord-331066-ediowz4s 221 46 ) ) -RRB- cord-331066-ediowz4s 221 47 and and CC cord-331066-ediowz4s 221 48 37 37 CD cord-331066-ediowz4s 221 49 motifs motif NNS cord-331066-ediowz4s 221 50 differing differ VBG cord-331066-ediowz4s 221 51 by by IN cord-331066-ediowz4s 221 52 one one CD cord-331066-ediowz4s 221 53 letter letter NN cord-331066-ediowz4s 221 54 at at IN cord-331066-ediowz4s 221 55 s s NNP cord-331066-ediowz4s 221 56 ¼ ¼ NNP cord-331066-ediowz4s 221 57 87 87 CD cord-331066-ediowz4s 221 58 . . . cord-331066-ediowz4s 222 1 This this DT cord-331066-ediowz4s 222 2 means mean VBZ cord-331066-ediowz4s 222 3 that that IN cord-331066-ediowz4s 222 4 the the DT cord-331066-ediowz4s 222 5 repertoires repertoire NNS cord-331066-ediowz4s 222 6 of of IN cord-331066-ediowz4s 222 7 relatively relatively RB cord-331066-ediowz4s 222 8 long long JJ cord-331066-ediowz4s 222 9 motifs motif NNS cord-331066-ediowz4s 222 10 are be VBP cord-331066-ediowz4s 222 11 robust robust JJ cord-331066-ediowz4s 222 12 to to TO cord-331066-ediowz4s 222 13 point point NN cord-331066-ediowz4s 222 14 mutations mutation NNS cord-331066-ediowz4s 222 15 and and CC cord-331066-ediowz4s 222 16 indels indel NNS cord-331066-ediowz4s 222 17 for for IN cord-331066-ediowz4s 222 18 the the DT cord-331066-ediowz4s 222 19 separate separate JJ cord-331066-ediowz4s 222 20 coronaviruses coronaviruse NNS cord-331066-ediowz4s 222 21 but but CC cord-331066-ediowz4s 222 22 diverge diverge VBP cord-331066-ediowz4s 222 23 ( ( -LRB- cord-331066-ediowz4s 222 24 and and CC cord-331066-ediowz4s 222 25 in in IN cord-331066-ediowz4s 222 26 this this DT cord-331066-ediowz4s 222 27 sense sense NN cord-331066-ediowz4s 222 28 are be VBP cord-331066-ediowz4s 222 29 specific specific JJ cord-331066-ediowz4s 222 30 enough enough RB cord-331066-ediowz4s 222 31 ) ) -RRB- cord-331066-ediowz4s 222 32 between between IN cord-331066-ediowz4s 222 33 the the DT cord-331066-ediowz4s 222 34 two two CD cord-331066-ediowz4s 222 35 viruses virus NNS cord-331066-ediowz4s 222 36 despite despite IN cord-331066-ediowz4s 222 37 the the DT cord-331066-ediowz4s 222 38 conservation conservation NN cord-331066-ediowz4s 222 39 of of IN cord-331066-ediowz4s 222 40 the the DT cord-331066-ediowz4s 222 41 main main JJ cord-331066-ediowz4s 222 42 helical helical JJ cord-331066-ediowz4s 222 43 periodicity periodicity NN cord-331066-ediowz4s 222 44 p p NN cord-331066-ediowz4s 222 45 % % NN cord-331066-ediowz4s 222 46 54 54 CD cord-331066-ediowz4s 222 47 nt nt RB cord-331066-ediowz4s 222 48 . . . cord-331066-ediowz4s 223 1 The the DT cord-331066-ediowz4s 223 2 relationships relationship NNS cord-331066-ediowz4s 223 3 between between IN cord-331066-ediowz4s 223 4 motifs motif NNS cord-331066-ediowz4s 223 5 found find VBN cord-331066-ediowz4s 223 6 for for IN cord-331066-ediowz4s 223 7 the the DT cord-331066-ediowz4s 223 8 assembly assembly NN cord-331066-ediowz4s 223 9 / / SYM cord-331066-ediowz4s 223 10 packaging packaging NN cord-331066-ediowz4s 223 11 and and CC cord-331066-ediowz4s 223 12 the the DT cord-331066-ediowz4s 223 13 other other JJ cord-331066-ediowz4s 223 14 cisacting cisacting NN cord-331066-ediowz4s 223 15 elements element NNS cord-331066-ediowz4s 223 16 ( ( -LRB- cord-331066-ediowz4s 223 17 Madhugiri Madhugiri NNP cord-331066-ediowz4s 223 18 et et NNP cord-331066-ediowz4s 223 19 al al NNP cord-331066-ediowz4s 223 20 . . NNP cord-331066-ediowz4s 223 21 , , , cord-331066-ediowz4s 223 22 2016 2016 CD cord-331066-ediowz4s 223 23 ) ) -RRB- cord-331066-ediowz4s 223 24 should should MD cord-331066-ediowz4s 223 25 be be VB cord-331066-ediowz4s 223 26 established establish VBN cord-331066-ediowz4s 223 27 separately separately RB cord-331066-ediowz4s 223 28 . . . cord-331066-ediowz4s 224 1 Our -PRON- PRP$ cord-331066-ediowz4s 224 2 study study NN cord-331066-ediowz4s 224 3 showed show VBD cord-331066-ediowz4s 224 4 that that IN cord-331066-ediowz4s 224 5 actually actually RB cord-331066-ediowz4s 224 6 any any DT cord-331066-ediowz4s 224 7 cis cis NNP cord-331066-ediowz4s 224 8 - - HYPH cord-331066-ediowz4s 224 9 acting act VBG cord-331066-ediowz4s 224 10 element element NN cord-331066-ediowz4s 224 11 should should MD cord-331066-ediowz4s 224 12 comprise comprise VB cord-331066-ediowz4s 224 13 contextual contextual JJ cord-331066-ediowz4s 224 14 surrounding surround VBG cord-331066-ediowz4s 224 15 vicinity vicinity NN cord-331066-ediowz4s 224 16 of of IN cord-331066-ediowz4s 224 17 several several JJ cord-331066-ediowz4s 224 18 tens ten NNS cord-331066-ediowz4s 224 19 of of IN cord-331066-ediowz4s 224 20 nucleotides nucleotide NNS cord-331066-ediowz4s 224 21 up up RB cord-331066-ediowz4s 224 22 - - : cord-331066-ediowz4s 224 23 and and CC cord-331066-ediowz4s 224 24 downstream downstream VB cord-331066-ediowz4s 224 25 the the DT cord-331066-ediowz4s 224 26 element element NN cord-331066-ediowz4s 224 27 . . . cord-331066-ediowz4s 225 1 The the DT cord-331066-ediowz4s 225 2 occurrences occurrence NNS cord-331066-ediowz4s 225 3 of of IN cord-331066-ediowz4s 225 4 the the DT cord-331066-ediowz4s 225 5 motifs motif NNS cord-331066-ediowz4s 225 6 determined determine VBN cord-331066-ediowz4s 225 7 by by IN cord-331066-ediowz4s 225 8 TAMGI TAMGI NNP cord-331066-ediowz4s 225 9 can can MD cord-331066-ediowz4s 225 10 be be VB cord-331066-ediowz4s 225 11 compared compare VBN cord-331066-ediowz4s 225 12 with with IN cord-331066-ediowz4s 225 13 their -PRON- PRP$ cord-331066-ediowz4s 225 14 counterparts counterpart NNS cord-331066-ediowz4s 225 15 in in IN cord-331066-ediowz4s 225 16 the the DT cord-331066-ediowz4s 225 17 whole whole JJ cord-331066-ediowz4s 225 18 genome genome NN cord-331066-ediowz4s 225 19 . . . cord-331066-ediowz4s 226 1 The the DT cord-331066-ediowz4s 226 2 statistical statistical JJ cord-331066-ediowz4s 226 3 significance significance NN cord-331066-ediowz4s 226 4 of of IN cord-331066-ediowz4s 226 5 such such JJ cord-331066-ediowz4s 226 6 motifs motif NNS cord-331066-ediowz4s 226 7 in in IN cord-331066-ediowz4s 226 8 the the DT cord-331066-ediowz4s 226 9 whole whole JJ cord-331066-ediowz4s 226 10 genome genome NN cord-331066-ediowz4s 226 11 can can MD cord-331066-ediowz4s 226 12 be be VB cord-331066-ediowz4s 226 13 assessed assess VBN cord-331066-ediowz4s 226 14 by by IN cord-331066-ediowz4s 226 15 the the DT cord-331066-ediowz4s 226 16 related related JJ cord-331066-ediowz4s 226 17 occurrences occurrence NNS cord-331066-ediowz4s 226 18 in in IN cord-331066-ediowz4s 226 19 the the DT cord-331066-ediowz4s 226 20 sequences sequence NNS cord-331066-ediowz4s 226 21 obtained obtain VBN cord-331066-ediowz4s 226 22 by by IN cord-331066-ediowz4s 226 23 the the DT cord-331066-ediowz4s 226 24 random random JJ cord-331066-ediowz4s 226 25 reshuffling reshuffling NN cord-331066-ediowz4s 226 26 of of IN cord-331066-ediowz4s 226 27 the the DT cord-331066-ediowz4s 226 28 genome genome NN cord-331066-ediowz4s 226 29 . . . cord-331066-ediowz4s 227 1 Instead instead RB cord-331066-ediowz4s 227 2 of of IN cord-331066-ediowz4s 227 3 modeling model VBG cord-331066-ediowz4s 227 4 with with IN cord-331066-ediowz4s 227 5 genome genome NN cord-331066-ediowz4s 227 6 reshuffling reshuffling NN cord-331066-ediowz4s 227 7 , , , cord-331066-ediowz4s 227 8 the the DT cord-331066-ediowz4s 227 9 rigorous rigorous JJ cord-331066-ediowz4s 227 10 theory theory NN cord-331066-ediowz4s 227 11 by by IN cord-331066-ediowz4s 227 12 Zubkov Zubkov NNP cord-331066-ediowz4s 227 13 and and CC cord-331066-ediowz4s 227 14 Mikhailov Mikhailov NNP cord-331066-ediowz4s 227 15 ( ( -LRB- cord-331066-ediowz4s 227 16 1974 1974 CD cord-331066-ediowz4s 227 17 ) ) -RRB- cord-331066-ediowz4s 227 18 and and CC cord-331066-ediowz4s 227 19 Karlin Karlin NNP cord-331066-ediowz4s 227 20 and and CC cord-331066-ediowz4s 227 21 Altschul Altschul NNP cord-331066-ediowz4s 227 22 ( ( -LRB- cord-331066-ediowz4s 227 23 1990 1990 CD cord-331066-ediowz4s 227 24 ) ) -RRB- cord-331066-ediowz4s 227 25 can can MD cord-331066-ediowz4s 227 26 be be VB cord-331066-ediowz4s 227 27 used use VBN cord-331066-ediowz4s 227 28 for for IN cord-331066-ediowz4s 227 29 the the DT cord-331066-ediowz4s 227 30 assessment assessment NN cord-331066-ediowz4s 227 31 of of IN cord-331066-ediowz4s 227 32 motif motif NN cord-331066-ediowz4s 227 33 occurrences occurrence NNS cord-331066-ediowz4s 227 34 ( ( -LRB- cord-331066-ediowz4s 227 35 see see VB cord-331066-ediowz4s 227 36 also also RB cord-331066-ediowz4s 227 37 Boeva Boeva NNP cord-331066-ediowz4s 227 38 et et NNP cord-331066-ediowz4s 227 39 al al NNP cord-331066-ediowz4s 227 40 . . NNP cord-331066-ediowz4s 227 41 , , , cord-331066-ediowz4s 227 42 2006 2006 CD cord-331066-ediowz4s 227 43 ; ; : cord-331066-ediowz4s 227 44 Suvorova Suvorova NNP cord-331066-ediowz4s 227 45 et et FW cord-331066-ediowz4s 227 46 al al NNP cord-331066-ediowz4s 227 47 . . NNP cord-331066-ediowz4s 227 48 , , , cord-331066-ediowz4s 227 49 2014 2014 CD cord-331066-ediowz4s 227 50 ) ) -RRB- cord-331066-ediowz4s 227 51 . . . cord-331066-ediowz4s 228 1 The the DT cord-331066-ediowz4s 228 2 total total JJ cord-331066-ediowz4s 228 3 frequencies frequency NNS cord-331066-ediowz4s 228 4 of of IN cord-331066-ediowz4s 228 5 nucleotides nucleotide NNS cord-331066-ediowz4s 228 6 after after IN cord-331066-ediowz4s 228 7 TAMGI TAMGI NNS cord-331066-ediowz4s 228 8 for for IN cord-331066-ediowz4s 228 9 the the DT cord-331066-ediowz4s 228 10 randomly randomly RB cord-331066-ediowz4s 228 11 reshuffled reshuffle VBN cord-331066-ediowz4s 228 12 genomic genomic JJ cord-331066-ediowz4s 228 13 sequences sequence NNS cord-331066-ediowz4s 228 14 were be VBD cord-331066-ediowz4s 228 15 calculated calculate VBN cord-331066-ediowz4s 228 16 by by IN cord-331066-ediowz4s 228 17 Equation Equation NNP cord-331066-ediowz4s 228 18 ( ( -LRB- cord-331066-ediowz4s 228 19 33 33 CD cord-331066-ediowz4s 228 20 ) ) -RRB- cord-331066-ediowz4s 228 21 . . . cord-331066-ediowz4s 229 1 Table table NN cord-331066-ediowz4s 229 2 2 2 CD cord-331066-ediowz4s 229 3 . . . cord-331066-ediowz4s 230 1 The the DT cord-331066-ediowz4s 230 2 occurrences occurrence NNS cord-331066-ediowz4s 230 3 of of IN cord-331066-ediowz4s 230 4 k k NNP cord-331066-ediowz4s 230 5 - - HYPH cord-331066-ediowz4s 230 6 mers mers NNP cord-331066-ediowz4s 230 7 , , , cord-331066-ediowz4s 230 8 -N -N : cord-331066-ediowz4s 230 9 k k XX cord-331066-ediowz4s 230 10 - - HYPH cord-331066-ediowz4s 230 11 , , , cord-331066-ediowz4s 230 12 in in IN cord-331066-ediowz4s 230 13 the the DT cord-331066-ediowz4s 230 14 genomes genome NNS cord-331066-ediowz4s 230 15 of of IN cord-331066-ediowz4s 230 16 SARS SARS NNP cord-331066-ediowz4s 230 17 - - HYPH cord-331066-ediowz4s 230 18 CoV CoV NNP cord-331066-ediowz4s 230 19 and and CC cord-331066-ediowz4s 230 20 SARS SARS NNP cord-331066-ediowz4s 230 21 - - HYPH cord-331066-ediowz4s 230 22 CoV-2 CoV-2 NNP cord-331066-ediowz4s 230 23 after after IN cord-331066-ediowz4s 230 24 TAMGI TAMGI NNP cord-331066-ediowz4s 230 25 with with IN cord-331066-ediowz4s 230 26 steps step NNS cord-331066-ediowz4s 230 27 s s NNP cord-331066-ediowz4s 230 28 ¼ ¼ NNP cord-331066-ediowz4s 230 29 54 54 CD cord-331066-ediowz4s 230 30 , , , cord-331066-ediowz4s 230 31 84 84 CD cord-331066-ediowz4s 230 32 and and CC cord-331066-ediowz4s 230 33 87 87 CD cord-331066-ediowz4s 230 34 . . . cord-331066-ediowz4s 231 1 Genome genome NN cord-331066-ediowz4s 231 2 accession accession NN cord-331066-ediowz4s 231 3 54 54 CD cord-331066-ediowz4s 231 4 _SP cord-331066-ediowz4s 231 5 1 1 CD cord-331066-ediowz4s 231 6 _SP cord-331066-ediowz4s 231 7 3618 3618 CD cord-331066-ediowz4s 231 8 _SP cord-331066-ediowz4s 231 9 3617 3617 CD cord-331066-ediowz4s 231 10 _SP cord-331066-ediowz4s 231 11 3633 3633 CD cord-331066-ediowz4s 231 12 _SP cord-331066-ediowz4s 231 13 3609 3609 CD cord-331066-ediowz4s 231 14 _SP cord-331066-ediowz4s 231 15 2 2 CD cord-331066-ediowz4s 231 16 _SP cord-331066-ediowz4s 231 17 1834 1834 CD cord-331066-ediowz4s 231 18 _SP cord-331066-ediowz4s 231 19 1823 1823 CD cord-331066-ediowz4s 231 20 _SP cord-331066-ediowz4s 231 21 1847 1847 CD cord-331066-ediowz4s 231 22 _SP cord-331066-ediowz4s 231 23 1828 1828 CD cord-331066-ediowz4s 231 24 _SP cord-331066-ediowz4s 232 1 3 3 CD cord-331066-ediowz4s 232 2 _SP cord-331066-ediowz4s 233 1 862 862 CD cord-331066-ediowz4s 233 2 _SP cord-331066-ediowz4s 234 1 898 898 CD cord-331066-ediowz4s 234 2 _SP cord-331066-ediowz4s 235 1 901 901 CD cord-331066-ediowz4s 235 2 _SP cord-331066-ediowz4s 235 3 901 901 CD cord-331066-ediowz4s 235 4 _SP cord-331066-ediowz4s 236 1 4 4 CD cord-331066-ediowz4s 236 2 _SP cord-331066-ediowz4s 236 3 458 458 CD cord-331066-ediowz4s 236 4 _SP cord-331066-ediowz4s 237 1 448 448 CD cord-331066-ediowz4s 237 2 _SP cord-331066-ediowz4s 238 1 449 449 CD cord-331066-ediowz4s 238 2 _SP cord-331066-ediowz4s 239 1 446 446 CD cord-331066-ediowz4s 239 2 _SP cord-331066-ediowz4s 240 1 5 5 CD cord-331066-ediowz4s 240 2 _SP cord-331066-ediowz4s 241 1 218 218 CD cord-331066-ediowz4s 241 2 _SP cord-331066-ediowz4s 242 1 226 226 CD cord-331066-ediowz4s 242 2 _SP cord-331066-ediowz4s 243 1 227 227 CD cord-331066-ediowz4s 243 2 _SP cord-331066-ediowz4s 244 1 226 226 CD cord-331066-ediowz4s 244 2 _SP cord-331066-ediowz4s 244 3 6 6 CD cord-331066-ediowz4s 244 4 _SP cord-331066-ediowz4s 244 5 106 106 CD cord-331066-ediowz4s 244 6 _SP cord-331066-ediowz4s 245 1 128 128 CD cord-331066-ediowz4s 245 2 _SP cord-331066-ediowz4s 246 1 125 125 CD cord-331066-ediowz4s 246 2 _SP cord-331066-ediowz4s 247 1 126 126 CD cord-331066-ediowz4s 247 2 _SP cord-331066-ediowz4s 248 1 7 7 CD cord-331066-ediowz4s 248 2 5 5 CD cord-331066-ediowz4s 248 3 1 1 CD cord-331066-ediowz4s 248 4 5 5 CD cord-331066-ediowz4s 248 5 1 1 CD cord-331066-ediowz4s 248 6 5 5 CD cord-331066-ediowz4s 248 7 2 2 CD cord-331066-ediowz4s 248 8 5 5 CD cord-331066-ediowz4s 248 9 2 2 CD cord-331066-ediowz4s 248 10 8 8 CD cord-331066-ediowz4s 248 11 2 2 CD cord-331066-ediowz4s 248 12 8 8 CD cord-331066-ediowz4s 248 13 2 2 CD cord-331066-ediowz4s 248 14 3 3 CD cord-331066-ediowz4s 248 15 2 2 CD cord-331066-ediowz4s 248 16 3 3 CD cord-331066-ediowz4s 248 17 2 2 CD cord-331066-ediowz4s 249 1 3 3 CD cord-331066-ediowz4s 249 2 9 9 CD cord-331066-ediowz4s 249 3 1 1 CD cord-331066-ediowz4s 249 4 6 6 CD cord-331066-ediowz4s 250 1 2 2 CD cord-331066-ediowz4s 250 2 1 1 CD cord-331066-ediowz4s 250 3 2 2 CD cord-331066-ediowz4s 250 4 0 0 CD cord-331066-ediowz4s 250 5 2 2 CD cord-331066-ediowz4s 250 6 0 0 CD cord-331066-ediowz4s 251 1 10 10 CD cord-331066-ediowz4s 251 2 5 5 CD cord-331066-ediowz4s 251 3 10 10 CD cord-331066-ediowz4s 251 4 10 10 CD cord-331066-ediowz4s 251 5 10 10 CD cord-331066-ediowz4s 251 6 11 11 CD cord-331066-ediowz4s 251 7 4 4 CD cord-331066-ediowz4s 251 8 2 2 CD cord-331066-ediowz4s 251 9 2 2 CD cord-331066-ediowz4s 251 10 2 2 CD cord-331066-ediowz4s 251 11 12 12 CD cord-331066-ediowz4s 251 12 5 5 CD cord-331066-ediowz4s 251 13 2 2 CD cord-331066-ediowz4s 251 14 2 2 CD cord-331066-ediowz4s 251 15 2 2 CD cord-331066-ediowz4s 251 16 13 13 CD cord-331066-ediowz4s 251 17 1 1 CD cord-331066-ediowz4s 251 18 --- --- SYM cord-331066-ediowz4s 251 19 4 4 CD cord-331066-ediowz4s 251 20 . . . cord-331066-ediowz4s 252 1 Discussion Discussion NNP cord-331066-ediowz4s 252 2 Short short JJ cord-331066-ediowz4s 252 3 tandem tandem NN cord-331066-ediowz4s 252 4 repeats repeat VBZ cord-331066-ediowz4s 252 5 in in IN cord-331066-ediowz4s 252 6 human human JJ cord-331066-ediowz4s 252 7 genomes genome NNS cord-331066-ediowz4s 252 8 are be VBP cord-331066-ediowz4s 252 9 widely widely RB cord-331066-ediowz4s 252 10 used use VBN cord-331066-ediowz4s 252 11 in in IN cord-331066-ediowz4s 252 12 the the DT cord-331066-ediowz4s 252 13 medical medical JJ cord-331066-ediowz4s 252 14 diagnostics diagnostic NNS cord-331066-ediowz4s 252 15 and and CC cord-331066-ediowz4s 252 16 forensic forensic JJ cord-331066-ediowz4s 252 17 ( ( -LRB- cord-331066-ediowz4s 252 18 see see VB cord-331066-ediowz4s 252 19 , , , cord-331066-ediowz4s 252 20 e.g. e.g. RB cord-331066-ediowz4s 252 21 Baine Baine NNP cord-331066-ediowz4s 252 22 & & CC cord-331066-ediowz4s 252 23 Hui Hui NNP cord-331066-ediowz4s 252 24 , , , cord-331066-ediowz4s 252 25 2019 2019 CD cord-331066-ediowz4s 252 26 ; ; : cord-331066-ediowz4s 252 27 Butler Butler NNP cord-331066-ediowz4s 252 28 , , , cord-331066-ediowz4s 252 29 2011 2011 CD cord-331066-ediowz4s 252 30 ; ; : cord-331066-ediowz4s 252 31 Grover Grover NNP cord-331066-ediowz4s 252 32 & & CC cord-331066-ediowz4s 252 33 Sharma Sharma NNP cord-331066-ediowz4s 252 34 , , , cord-331066-ediowz4s 252 35 2016 2016 CD cord-331066-ediowz4s 252 36 ; ; : cord-331066-ediowz4s 252 37 Kayser Kayser NNP cord-331066-ediowz4s 252 38 , , , cord-331066-ediowz4s 252 39 2017 2017 CD cord-331066-ediowz4s 252 40 ; ; : cord-331066-ediowz4s 252 41 Sznajder Sznajder NNP cord-331066-ediowz4s 252 42 & & CC cord-331066-ediowz4s 252 43 Swanson Swanson NNP cord-331066-ediowz4s 252 44 , , , cord-331066-ediowz4s 252 45 2019 2019 CD cord-331066-ediowz4s 252 46 ; ; : cord-331066-ediowz4s 252 47 and and CC cord-331066-ediowz4s 252 48 references reference NNS cord-331066-ediowz4s 252 49 therein therein RB cord-331066-ediowz4s 252 50 ) ) -RRB- cord-331066-ediowz4s 252 51 . . . cord-331066-ediowz4s 253 1 Similar similar JJ cord-331066-ediowz4s 253 2 patterns pattern NNS cord-331066-ediowz4s 253 3 were be VBD cord-331066-ediowz4s 253 4 also also RB cord-331066-ediowz4s 253 5 found find VBN cord-331066-ediowz4s 253 6 in in IN cord-331066-ediowz4s 253 7 some some DT cord-331066-ediowz4s 253 8 prokaryotic prokaryotic JJ cord-331066-ediowz4s 253 9 genomes genome NNS cord-331066-ediowz4s 253 10 ( ( -LRB- cord-331066-ediowz4s 253 11 Subirana Subirana NNP cord-331066-ediowz4s 253 12 & & CC cord-331066-ediowz4s 253 13 Messeguer Messeguer NNP cord-331066-ediowz4s 253 14 , , , cord-331066-ediowz4s 253 15 2019 2019 CD cord-331066-ediowz4s 253 16 ) ) -RRB- cord-331066-ediowz4s 253 17 . . . cord-331066-ediowz4s 254 1 Quasi quasi JJ cord-331066-ediowz4s 254 2 - - JJ cord-331066-ediowz4s 254 3 repeating repeat VBG cord-331066-ediowz4s 254 4 patterns pattern NNS cord-331066-ediowz4s 254 5 in in IN cord-331066-ediowz4s 254 6 viral viral JJ cord-331066-ediowz4s 254 7 genomes genome NNS cord-331066-ediowz4s 254 8 are be VBP cord-331066-ediowz4s 254 9 present present JJ cord-331066-ediowz4s 254 10 commonly commonly RB cord-331066-ediowz4s 254 11 in in IN cord-331066-ediowz4s 254 12 the the DT cord-331066-ediowz4s 254 13 hidden hide VBN cord-331066-ediowz4s 254 14 form form NN cord-331066-ediowz4s 254 15 on on IN cord-331066-ediowz4s 254 16 the the DT cord-331066-ediowz4s 254 17 background background NN cord-331066-ediowz4s 254 18 of of IN cord-331066-ediowz4s 254 19 frequent frequent JJ cord-331066-ediowz4s 254 20 random random JJ cord-331066-ediowz4s 254 21 point point NN cord-331066-ediowz4s 254 22 mutations mutation NNS cord-331066-ediowz4s 254 23 and and CC cord-331066-ediowz4s 254 24 indels indel NNS cord-331066-ediowz4s 254 25 . . . cord-331066-ediowz4s 255 1 Nevertheless nevertheless RB cord-331066-ediowz4s 255 2 , , , cord-331066-ediowz4s 255 3 many many JJ cord-331066-ediowz4s 255 4 quasi quasi JJ cord-331066-ediowz4s 255 5 - - JJ cord-331066-ediowz4s 255 6 repeating repeating JJ cord-331066-ediowz4s 255 7 patterns pattern NNS cord-331066-ediowz4s 255 8 remain remain VBP cord-331066-ediowz4s 255 9 persistent persistent JJ cord-331066-ediowz4s 255 10 , , , cord-331066-ediowz4s 255 11 robust robust JJ cord-331066-ediowz4s 255 12 and and CC cord-331066-ediowz4s 255 13 contain contain VBP cord-331066-ediowz4s 255 14 important important JJ cord-331066-ediowz4s 255 15 information information NN cord-331066-ediowz4s 255 16 about about IN cord-331066-ediowz4s 255 17 molecular molecular JJ cord-331066-ediowz4s 255 18 mechanisms mechanism NNS cord-331066-ediowz4s 255 19 of of IN cord-331066-ediowz4s 255 20 virus virus NN cord-331066-ediowz4s 255 21 life life NN cord-331066-ediowz4s 255 22 cycle cycle NN cord-331066-ediowz4s 255 23 , , , cord-331066-ediowz4s 255 24 including include VBG cord-331066-ediowz4s 255 25 genome genome NN cord-331066-ediowz4s 255 26 packaging packaging NN cord-331066-ediowz4s 255 27 . . . cord-331066-ediowz4s 256 1 Such such JJ cord-331066-ediowz4s 256 2 patterns pattern NNS cord-331066-ediowz4s 256 3 can can MD cord-331066-ediowz4s 256 4 be be VB cord-331066-ediowz4s 256 5 detected detect VBN cord-331066-ediowz4s 256 6 and and CC cord-331066-ediowz4s 256 7 quantified quantify VBN cord-331066-ediowz4s 256 8 by by IN cord-331066-ediowz4s 256 9 DFT DFT NNP cord-331066-ediowz4s 256 10 , , , cord-331066-ediowz4s 256 11 DDFT DDFT NNP cord-331066-ediowz4s 256 12 , , , cord-331066-ediowz4s 256 13 NCF NCF NNP cord-331066-ediowz4s 256 14 and and CC cord-331066-ediowz4s 256 15 other other JJ cord-331066-ediowz4s 256 16 methods method NNS cord-331066-ediowz4s 256 17 . . . cord-331066-ediowz4s 257 1 Surprisingly surprisingly RB cord-331066-ediowz4s 257 2 , , , cord-331066-ediowz4s 257 3 the the DT cord-331066-ediowz4s 257 4 quasirepeating quasirepeating NN cord-331066-ediowz4s 257 5 patterns pattern NNS cord-331066-ediowz4s 257 6 in in IN cord-331066-ediowz4s 257 7 viral viral JJ cord-331066-ediowz4s 257 8 genomes genome NNS cord-331066-ediowz4s 257 9 are be VBP cord-331066-ediowz4s 257 10 usually usually RB cord-331066-ediowz4s 257 11 completely completely RB cord-331066-ediowz4s 257 12 ignored ignore VBN cord-331066-ediowz4s 257 13 when when WRB cord-331066-ediowz4s 257 14 discussing discuss VBG cord-331066-ediowz4s 257 15 evolutionary evolutionary JJ cord-331066-ediowz4s 257 16 and and CC cord-331066-ediowz4s 257 17 subtyping subtyping NN cord-331066-ediowz4s 257 18 problems problem NNS cord-331066-ediowz4s 257 19 in in IN cord-331066-ediowz4s 257 20 virology virology NN cord-331066-ediowz4s 257 21 ( ( -LRB- cord-331066-ediowz4s 257 22 see see VB cord-331066-ediowz4s 257 23 , , , cord-331066-ediowz4s 257 24 e.g. e.g. RB cord-331066-ediowz4s 257 25 Andersen Andersen NNP cord-331066-ediowz4s 257 26 et et NNP cord-331066-ediowz4s 257 27 al al NNP cord-331066-ediowz4s 257 28 . . NNP cord-331066-ediowz4s 257 29 , , , cord-331066-ediowz4s 257 30 2020 2020 CD cord-331066-ediowz4s 257 31 ; ; : cord-331066-ediowz4s 257 32 Cagliani Cagliani NNP cord-331066-ediowz4s 257 33 et et NNP cord-331066-ediowz4s 257 34 al al NNP cord-331066-ediowz4s 257 35 . . . cord-331066-ediowz4s 258 1 , , , cord-331066-ediowz4s 258 2 2020 2020 CD cord-331066-ediowz4s 258 3 ; ; : cord-331066-ediowz4s 258 4 Forster Forster NNP cord-331066-ediowz4s 258 5 et et NNP cord-331066-ediowz4s 258 6 al al NNP cord-331066-ediowz4s 258 7 . . . cord-331066-ediowz4s 259 1 , , , cord-331066-ediowz4s 259 2 2020 2020 CD cord-331066-ediowz4s 259 3 ; ; : cord-331066-ediowz4s 259 4 MacLean MacLean NNP cord-331066-ediowz4s 259 5 et et NNP cord-331066-ediowz4s 259 6 al al NNP cord-331066-ediowz4s 259 7 . . . cord-331066-ediowz4s 260 1 , , , cord-331066-ediowz4s 260 2 2020 2020 CD cord-331066-ediowz4s 260 3 ; ; : cord-331066-ediowz4s 260 4 Tang Tang NNP cord-331066-ediowz4s 260 5 et et NNP cord-331066-ediowz4s 260 6 al al NNP cord-331066-ediowz4s 260 7 . . NNP cord-331066-ediowz4s 260 8 , , , cord-331066-ediowz4s 260 9 2020 2020 CD cord-331066-ediowz4s 260 10 ) ) -RRB- cord-331066-ediowz4s 260 11 . . . cord-331066-ediowz4s 261 1 The the DT cord-331066-ediowz4s 261 2 general general JJ cord-331066-ediowz4s 261 3 abundance abundance NN cord-331066-ediowz4s 261 4 of of IN cord-331066-ediowz4s 261 5 quasi quasi JJ cord-331066-ediowz4s 261 6 - - JJ cord-331066-ediowz4s 261 7 periodic periodic JJ cord-331066-ediowz4s 261 8 patterns pattern NNS cord-331066-ediowz4s 261 9 in in IN cord-331066-ediowz4s 261 10 viral viral JJ cord-331066-ediowz4s 261 11 genomes genome NNS cord-331066-ediowz4s 261 12 can can MD cord-331066-ediowz4s 261 13 be be VB cord-331066-ediowz4s 261 14 conveniently conveniently RB cord-331066-ediowz4s 261 15 assessed assess VBN cord-331066-ediowz4s 261 16 by by IN cord-331066-ediowz4s 261 17 the the DT cord-331066-ediowz4s 261 18 relative relative JJ cord-331066-ediowz4s 261 19 spectral spectral JJ cord-331066-ediowz4s 261 20 entropy entropy NN cord-331066-ediowz4s 261 21 ( ( -LRB- cord-331066-ediowz4s 261 22 Subsection subsection NN cord-331066-ediowz4s 261 23 2.5 2.5 CD cord-331066-ediowz4s 261 24 ) ) -RRB- cord-331066-ediowz4s 261 25 . . . cord-331066-ediowz4s 262 1 The the DT cord-331066-ediowz4s 262 2 more more RBR cord-331066-ediowz4s 262 3 negative negative JJ cord-331066-ediowz4s 262 4 the the DT cord-331066-ediowz4s 262 5 spectral spectral JJ cord-331066-ediowz4s 262 6 entropy entropy NN cord-331066-ediowz4s 262 7 , , , cord-331066-ediowz4s 262 8 the the DT cord-331066-ediowz4s 262 9 higher high JJR cord-331066-ediowz4s 262 10 the the DT cord-331066-ediowz4s 262 11 abundance abundance NN cord-331066-ediowz4s 262 12 of of IN cord-331066-ediowz4s 262 13 quasi quasi JJ cord-331066-ediowz4s 262 14 - - JJ cord-331066-ediowz4s 262 15 periodic periodic JJ cord-331066-ediowz4s 262 16 patterns pattern NNS cord-331066-ediowz4s 262 17 in in IN cord-331066-ediowz4s 262 18 the the DT cord-331066-ediowz4s 262 19 genome genome NN cord-331066-ediowz4s 262 20 . . . cord-331066-ediowz4s 263 1 The the DT cord-331066-ediowz4s 263 2 relevant relevant JJ cord-331066-ediowz4s 263 3 data datum NNS cord-331066-ediowz4s 263 4 for for IN cord-331066-ediowz4s 263 5 the the DT cord-331066-ediowz4s 263 6 genomes genome NNS cord-331066-ediowz4s 263 7 of of IN cord-331066-ediowz4s 263 8 SARS SARS NNP cord-331066-ediowz4s 263 9 - - HYPH cord-331066-ediowz4s 263 10 CoV CoV NNP cord-331066-ediowz4s 263 11 and and CC cord-331066-ediowz4s 263 12 three three CD cord-331066-ediowz4s 263 13 isolates isolate NNS cord-331066-ediowz4s 263 14 of of IN cord-331066-ediowz4s 263 15 SARS SARS NNP cord-331066-ediowz4s 263 16 - - HYPH cord-331066-ediowz4s 263 17 CoV-2 CoV-2 NNP cord-331066-ediowz4s 263 18 are be VBP cord-331066-ediowz4s 263 19 summarized summarize VBN cord-331066-ediowz4s 263 20 in in IN cord-331066-ediowz4s 263 21 Table Table NNP cord-331066-ediowz4s 263 22 3 3 CD cord-331066-ediowz4s 263 23 . . . cord-331066-ediowz4s 264 1 For for IN cord-331066-ediowz4s 264 2 the the DT cord-331066-ediowz4s 264 3 significance significance NN cord-331066-ediowz4s 264 4 Pr Pr NNP cord-331066-ediowz4s 264 5 ¼ ¼ NNP cord-331066-ediowz4s 264 6 0.05 0.05 CD cord-331066-ediowz4s 264 7 , , , cord-331066-ediowz4s 264 8 the the DT cord-331066-ediowz4s 264 9 difference difference NN cord-331066-ediowz4s 264 10 between between IN cord-331066-ediowz4s 264 11 the the DT cord-331066-ediowz4s 264 12 total total JJ cord-331066-ediowz4s 264 13 spectral spectral JJ cord-331066-ediowz4s 264 14 entropies entropy NNS cord-331066-ediowz4s 264 15 should should MD cord-331066-ediowz4s 264 16 exceed exceed VB cord-331066-ediowz4s 264 17 by by IN cord-331066-ediowz4s 264 18 the the DT cord-331066-ediowz4s 264 19 absolute absolute JJ cord-331066-ediowz4s 264 20 value value NN cord-331066-ediowz4s 264 21 the the DT cord-331066-ediowz4s 264 22 threshold threshold NN cord-331066-ediowz4s 264 23 1:96 1:96 CD cord-331066-ediowz4s 264 24 ffiffi ffiffi NNP cord-331066-ediowz4s 264 25 ffi ffi NNP cord-331066-ediowz4s 264 26 2 2 CD cord-331066-ediowz4s 264 27 p p NNP cord-331066-ediowz4s 264 28 rðS rðS NNP cord-331066-ediowz4s 264 29 total total NN cord-331066-ediowz4s 264 30 , , , cord-331066-ediowz4s 264 31 rel rel NNP cord-331066-ediowz4s 265 1 Þ% Þ% NNP cord-331066-ediowz4s 265 2 0.055 0.055 CD cord-331066-ediowz4s 265 3 . . . cord-331066-ediowz4s 266 1 This this DT cord-331066-ediowz4s 266 2 is be VBZ cord-331066-ediowz4s 266 3 actually actually RB cord-331066-ediowz4s 266 4 fulfilled fulfil VBN cord-331066-ediowz4s 266 5 for for IN cord-331066-ediowz4s 266 6 all all DT cord-331066-ediowz4s 266 7 three three CD cord-331066-ediowz4s 266 8 differences difference NNS cord-331066-ediowz4s 266 9 between between IN cord-331066-ediowz4s 266 10 S S NNP cord-331066-ediowz4s 266 11 total total NN cord-331066-ediowz4s 266 12 , , , cord-331066-ediowz4s 266 13 rel rel NNP cord-331066-ediowz4s 266 14 for for IN cord-331066-ediowz4s 266 15 SARS SARS NNP cord-331066-ediowz4s 266 16 - - HYPH cord-331066-ediowz4s 266 17 CoV CoV NNP cord-331066-ediowz4s 266 18 and and CC cord-331066-ediowz4s 266 19 the the DT cord-331066-ediowz4s 266 20 isolates isolate NNS cord-331066-ediowz4s 266 21 of of IN cord-331066-ediowz4s 266 22 SARS SARS NNP cord-331066-ediowz4s 266 23 - - HYPH cord-331066-ediowz4s 266 24 CoV-2 CoV-2 NNP cord-331066-ediowz4s 266 25 , , , cord-331066-ediowz4s 266 26 whereas whereas IN cord-331066-ediowz4s 266 27 the the DT cord-331066-ediowz4s 266 28 mutual mutual JJ cord-331066-ediowz4s 266 29 differences difference NNS cord-331066-ediowz4s 266 30 between between IN cord-331066-ediowz4s 266 31 S S NNP cord-331066-ediowz4s 266 32 total total NN cord-331066-ediowz4s 266 33 , , , cord-331066-ediowz4s 266 34 rel rel NNP cord-331066-ediowz4s 266 35 for for IN cord-331066-ediowz4s 266 36 the the DT cord-331066-ediowz4s 266 37 isolates isolate NNS cord-331066-ediowz4s 266 38 of of IN cord-331066-ediowz4s 266 39 SARS SARS NNP cord-331066-ediowz4s 266 40 - - HYPH cord-331066-ediowz4s 266 41 CoV-2 CoV-2 NNP cord-331066-ediowz4s 266 42 are be VBP cord-331066-ediowz4s 266 43 less less JJR cord-331066-ediowz4s 266 44 , , , cord-331066-ediowz4s 266 45 that that DT cord-331066-ediowz4s 266 46 is be VBZ cord-331066-ediowz4s 266 47 in in IN cord-331066-ediowz4s 266 48 accordance accordance NN cord-331066-ediowz4s 266 49 with with IN cord-331066-ediowz4s 266 50 the the DT cord-331066-ediowz4s 266 51 evolutionary evolutionary JJ cord-331066-ediowz4s 266 52 divergence divergence NN cord-331066-ediowz4s 266 53 of of IN cord-331066-ediowz4s 266 54 SARS SARS NNP cord-331066-ediowz4s 266 55 - - HYPH cord-331066-ediowz4s 266 56 CoV CoV NNP cord-331066-ediowz4s 266 57 and and CC cord-331066-ediowz4s 266 58 SARS SARS NNP cord-331066-ediowz4s 266 59 - - HYPH cord-331066-ediowz4s 266 60 CoV-2 CoV-2 NNP cord-331066-ediowz4s 266 61 . . . cord-331066-ediowz4s 267 1 The the DT cord-331066-ediowz4s 267 2 values value NNS cord-331066-ediowz4s 267 3 of of IN cord-331066-ediowz4s 267 4 S S NNP cord-331066-ediowz4s 267 5 total total NN cord-331066-ediowz4s 267 6 , , , cord-331066-ediowz4s 267 7 rel rel NNP cord-331066-ediowz4s 267 8 in in IN cord-331066-ediowz4s 267 9 Table Table NNP cord-331066-ediowz4s 267 10 3 3 CD cord-331066-ediowz4s 267 11 reveal reveal VBP cord-331066-ediowz4s 267 12 the the DT cord-331066-ediowz4s 267 13 higher high JJR cord-331066-ediowz4s 267 14 abundance abundance NN cord-331066-ediowz4s 267 15 of of IN cord-331066-ediowz4s 267 16 periodic periodic JJ cord-331066-ediowz4s 267 17 patterns pattern NNS cord-331066-ediowz4s 267 18 in in IN cord-331066-ediowz4s 267 19 the the DT cord-331066-ediowz4s 267 20 SARS SARS NNP cord-331066-ediowz4s 267 21 - - HYPH cord-331066-ediowz4s 267 22 CoV-2 CoV-2 NNP cord-331066-ediowz4s 267 23 genomes genome NNS cord-331066-ediowz4s 267 24 in in IN cord-331066-ediowz4s 267 25 comparison comparison NN cord-331066-ediowz4s 267 26 with with IN cord-331066-ediowz4s 267 27 the the DT cord-331066-ediowz4s 267 28 SARS SARS NNP cord-331066-ediowz4s 267 29 - - HYPH cord-331066-ediowz4s 267 30 CoV CoV NNP cord-331066-ediowz4s 267 31 genome genome NN cord-331066-ediowz4s 267 32 . . . cord-331066-ediowz4s 268 1 It -PRON- PRP cord-331066-ediowz4s 268 2 can can MD cord-331066-ediowz4s 268 3 also also RB cord-331066-ediowz4s 268 4 be be VB cord-331066-ediowz4s 268 5 said say VBN cord-331066-ediowz4s 268 6 that that IN cord-331066-ediowz4s 268 7 during during IN cord-331066-ediowz4s 268 8 virus virus NN cord-331066-ediowz4s 268 9 age age NN cord-331066-ediowz4s 268 10 the the DT cord-331066-ediowz4s 268 11 load load NN cord-331066-ediowz4s 268 12 from from IN cord-331066-ediowz4s 268 13 point point NN cord-331066-ediowz4s 268 14 mutations mutation NNS cord-331066-ediowz4s 268 15 and and CC cord-331066-ediowz4s 268 16 indels indel NNS cord-331066-ediowz4s 268 17 on on IN cord-331066-ediowz4s 268 18 the the DT cord-331066-ediowz4s 268 19 genome genome NN cord-331066-ediowz4s 268 20 of of IN cord-331066-ediowz4s 268 21 SARS SARS NNP cord-331066-ediowz4s 268 22 - - HYPH cord-331066-ediowz4s 268 23 CoV CoV NNP cord-331066-ediowz4s 268 24 was be VBD cord-331066-ediowz4s 268 25 higher high JJR cord-331066-ediowz4s 268 26 in in IN cord-331066-ediowz4s 268 27 comparison comparison NN cord-331066-ediowz4s 268 28 with with IN cord-331066-ediowz4s 268 29 the the DT cord-331066-ediowz4s 268 30 load load NN cord-331066-ediowz4s 268 31 on on IN cord-331066-ediowz4s 268 32 the the DT cord-331066-ediowz4s 268 33 genome genome NN cord-331066-ediowz4s 268 34 of of IN cord-331066-ediowz4s 268 35 SARS SARS NNP cord-331066-ediowz4s 268 36 - - HYPH cord-331066-ediowz4s 268 37 CoV-2 CoV-2 NNP cord-331066-ediowz4s 268 38 . . . cord-331066-ediowz4s 269 1 Within within IN cord-331066-ediowz4s 269 2 such such JJ cord-331066-ediowz4s 269 3 interpretation interpretation NN cord-331066-ediowz4s 269 4 SARS SARS NNP cord-331066-ediowz4s 269 5 - - HYPH cord-331066-ediowz4s 269 6 CoV-2 CoV-2 NNP cord-331066-ediowz4s 269 7 may may MD cord-331066-ediowz4s 269 8 be be VB cord-331066-ediowz4s 269 9 treated treat VBN cord-331066-ediowz4s 269 10 as as IN cord-331066-ediowz4s 269 11 a a DT cord-331066-ediowz4s 269 12 ' ' `` cord-331066-ediowz4s 269 13 newborn newborn JJ cord-331066-ediowz4s 269 14 ' ' '' cord-331066-ediowz4s 269 15 virus virus NN cord-331066-ediowz4s 269 16 . . . cord-331066-ediowz4s 270 1 4.2 4.2 CD cord-331066-ediowz4s 270 2 . . . cord-331066-ediowz4s 271 1 How how WRB cord-331066-ediowz4s 271 2 many many JJ cord-331066-ediowz4s 271 3 N n CD cord-331066-ediowz4s 271 4 proteins protein NNS cord-331066-ediowz4s 271 5 are be VBP cord-331066-ediowz4s 271 6 needed need VBN cord-331066-ediowz4s 271 7 for for IN cord-331066-ediowz4s 271 8 the the DT cord-331066-ediowz4s 271 9 complete complete JJ cord-331066-ediowz4s 271 10 packaging packaging NN cord-331066-ediowz4s 271 11 of of IN cord-331066-ediowz4s 271 12 the the DT cord-331066-ediowz4s 271 13 SARS SARS NNP cord-331066-ediowz4s 271 14 - - HYPH cord-331066-ediowz4s 271 15 CoV CoV NNP cord-331066-ediowz4s 271 16 and and CC cord-331066-ediowz4s 271 17 SARS SARS NNP cord-331066-ediowz4s 271 18 - - HYPH cord-331066-ediowz4s 271 19 CoV-2 CoV-2 NNP cord-331066-ediowz4s 271 20 ssRNA ssrna NN cord-331066-ediowz4s 271 21 genomes genome NNS cord-331066-ediowz4s 271 22 ? ? . cord-331066-ediowz4s 272 1 The the DT cord-331066-ediowz4s 272 2 periods period NNS cord-331066-ediowz4s 272 3 of of IN cord-331066-ediowz4s 272 4 ssRNA ssrna NN cord-331066-ediowz4s 272 5 turns turn NNS cord-331066-ediowz4s 272 6 packaged package VBN cord-331066-ediowz4s 272 7 within within IN cord-331066-ediowz4s 272 8 the the DT cord-331066-ediowz4s 272 9 helical helical JJ cord-331066-ediowz4s 272 10 ribonucleocapsid ribonucleocapsid NN cord-331066-ediowz4s 272 11 and and CC cord-331066-ediowz4s 272 12 detected detect VBD cord-331066-ediowz4s 272 13 via via IN cord-331066-ediowz4s 272 14 repeating repeat VBG cord-331066-ediowz4s 272 15 motifs motif NNS cord-331066-ediowz4s 272 16 in in IN cord-331066-ediowz4s 272 17 the the DT cord-331066-ediowz4s 272 18 genomic genomic JJ cord-331066-ediowz4s 272 19 RNA RNA NNP cord-331066-ediowz4s 272 20 sequences sequence NNS cord-331066-ediowz4s 272 21 proved prove VBD cord-331066-ediowz4s 272 22 to to TO cord-331066-ediowz4s 272 23 be be VB cord-331066-ediowz4s 272 24 persistent persistent JJ cord-331066-ediowz4s 272 25 in in IN cord-331066-ediowz4s 272 26 the the DT cord-331066-ediowz4s 272 27 genomes genome NNS cord-331066-ediowz4s 272 28 of of IN cord-331066-ediowz4s 272 29 SARS SARS NNP cord-331066-ediowz4s 272 30 - - HYPH cord-331066-ediowz4s 272 31 CoV CoV NNP cord-331066-ediowz4s 272 32 and and CC cord-331066-ediowz4s 272 33 SARS SARS NNP cord-331066-ediowz4s 272 34 - - HYPH cord-331066-ediowz4s 272 35 CoV-2 CoV-2 NNP cord-331066-ediowz4s 272 36 , , , cord-331066-ediowz4s 272 37 although although IN cord-331066-ediowz4s 272 38 , , , cord-331066-ediowz4s 272 39 the the DT cord-331066-ediowz4s 272 40 repertoires repertoire NNS cord-331066-ediowz4s 272 41 of of IN cord-331066-ediowz4s 272 42 related related JJ cord-331066-ediowz4s 272 43 motifs motif NNS cord-331066-ediowz4s 272 44 appeared appear VBD cord-331066-ediowz4s 272 45 to to TO cord-331066-ediowz4s 272 46 be be VB cord-331066-ediowz4s 272 47 divergent divergent JJ cord-331066-ediowz4s 272 48 . . . cord-331066-ediowz4s 273 1 Taking take VBG cord-331066-ediowz4s 273 2 into into IN cord-331066-ediowz4s 273 3 account account NN cord-331066-ediowz4s 273 4 that that IN cord-331066-ediowz4s 273 5 the the DT cord-331066-ediowz4s 273 6 turn turn NN cord-331066-ediowz4s 273 7 of of IN cord-331066-ediowz4s 273 8 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 273 9 is be VBZ cord-331066-ediowz4s 273 10 composed compose VBN cord-331066-ediowz4s 273 11 of of IN cord-331066-ediowz4s 273 12 two two CD cord-331066-ediowz4s 273 13 octamers octamer NNS cord-331066-ediowz4s 273 14 ( ( -LRB- cord-331066-ediowz4s 273 15 Chen Chen NNP cord-331066-ediowz4s 273 16 et et NNP cord-331066-ediowz4s 273 17 al al NNP cord-331066-ediowz4s 273 18 . . NNP cord-331066-ediowz4s 273 19 , , , cord-331066-ediowz4s 273 20 2007 2007 CD cord-331066-ediowz4s 273 21 ) ) -RRB- cord-331066-ediowz4s 273 22 polymerized polymerize VBN cord-331066-ediowz4s 273 23 from from IN cord-331066-ediowz4s 273 24 dimeric dimeric JJ cord-331066-ediowz4s 273 25 N n CD cord-331066-ediowz4s 273 26 proteins protein NNS cord-331066-ediowz4s 273 27 , , , cord-331066-ediowz4s 273 28 the the DT cord-331066-ediowz4s 273 29 detected detected JJ cord-331066-ediowz4s 273 30 period period NN cord-331066-ediowz4s 273 31 of of IN cord-331066-ediowz4s 273 32 54 54 CD cord-331066-ediowz4s 273 33 nt nt RB cord-331066-ediowz4s 273 34 implies imply VBZ cord-331066-ediowz4s 273 35 that that IN cord-331066-ediowz4s 273 36 one one CD cord-331066-ediowz4s 273 37 N n CD cord-331066-ediowz4s 273 38 protein protein NN cord-331066-ediowz4s 273 39 should should MD cord-331066-ediowz4s 273 40 be be VB cord-331066-ediowz4s 273 41 associated associate VBN cord-331066-ediowz4s 273 42 with with IN cord-331066-ediowz4s 273 43 6.75 6.75 CD cord-331066-ediowz4s 273 44 nt nt RB cord-331066-ediowz4s 273 45 . . . cord-331066-ediowz4s 274 1 This this DT cord-331066-ediowz4s 274 2 is be VBZ cord-331066-ediowz4s 274 3 very very RB cord-331066-ediowz4s 274 4 close close JJ cord-331066-ediowz4s 274 5 to to IN cord-331066-ediowz4s 274 6 the the DT cord-331066-ediowz4s 274 7 estimate estimate NN cord-331066-ediowz4s 274 8 obtained obtain VBN cord-331066-ediowz4s 274 9 by by IN cord-331066-ediowz4s 274 10 Chang Chang NNP cord-331066-ediowz4s 274 11 et et NNP cord-331066-ediowz4s 274 12 al al NNP cord-331066-ediowz4s 274 13 . . . cord-331066-ediowz4s 275 1 ( ( -LRB- cord-331066-ediowz4s 275 2 2014 2014 CD cord-331066-ediowz4s 275 3 ) ) -RRB- cord-331066-ediowz4s 276 1 that that DT cord-331066-ediowz4s 276 2 one one CD cord-331066-ediowz4s 276 3 N n CD cord-331066-ediowz4s 276 4 protein protein NN cord-331066-ediowz4s 276 5 should should MD cord-331066-ediowz4s 276 6 be be VB cord-331066-ediowz4s 276 7 associated associate VBN cord-331066-ediowz4s 276 8 with with IN cord-331066-ediowz4s 276 9 7 7 CD cord-331066-ediowz4s 276 10 nt nt NN cord-331066-ediowz4s 276 11 . . . cord-331066-ediowz4s 277 1 Consequently consequently RB cord-331066-ediowz4s 277 2 , , , cord-331066-ediowz4s 277 3 for for IN cord-331066-ediowz4s 277 4 genomes genome NNS cord-331066-ediowz4s 277 5 of of IN cord-331066-ediowz4s 277 6 length length NN cord-331066-ediowz4s 277 7 30,000 30,000 CD cord-331066-ediowz4s 277 8 nt nt RB cord-331066-ediowz4s 277 9 typical typical JJ cord-331066-ediowz4s 277 10 of of IN cord-331066-ediowz4s 277 11 coronaviruses coronaviruse NNS cord-331066-ediowz4s 277 12 , , , cord-331066-ediowz4s 278 1 4.4 4.4 CD cord-331066-ediowz4s 278 2 Â â CD cord-331066-ediowz4s 278 3 10 10 CD cord-331066-ediowz4s 278 4 3 3 CD cord-331066-ediowz4s 278 5 N n CD cord-331066-ediowz4s 278 6 proteins protein NNS cord-331066-ediowz4s 278 7 are be VBP cord-331066-ediowz4s 278 8 needed need VBN cord-331066-ediowz4s 278 9 for for IN cord-331066-ediowz4s 278 10 complete complete JJ cord-331066-ediowz4s 278 11 packaging packaging NN cord-331066-ediowz4s 278 12 of of IN cord-331066-ediowz4s 278 13 the the DT cord-331066-ediowz4s 278 14 genomic genomic NN cord-331066-ediowz4s 278 15 ssRNA ssrna NN cord-331066-ediowz4s 278 16 . . . cord-331066-ediowz4s 279 1 The the DT cord-331066-ediowz4s 279 2 latter latter JJ cord-331066-ediowz4s 279 3 estimate estimate NN cord-331066-ediowz4s 279 4 significantly significantly RB cord-331066-ediowz4s 279 5 exceeds exceed VBZ cord-331066-ediowz4s 279 6 the the DT cord-331066-ediowz4s 279 7 value value NN cord-331066-ediowz4s 279 8 suggested suggest VBN cord-331066-ediowz4s 279 9 by by IN cord-331066-ediowz4s 279 10 Neuman Neuman NNP cord-331066-ediowz4s 279 11 and and CC cord-331066-ediowz4s 279 12 Buchmeier Buchmeier NNP cord-331066-ediowz4s 279 13 ( ( -LRB- cord-331066-ediowz4s 279 14 2016 2016 CD cord-331066-ediowz4s 279 15 ) ) -RRB- cord-331066-ediowz4s 279 16 , , , cord-331066-ediowz4s 279 17 0.7 0.7 CD cord-331066-ediowz4s 279 18 - - SYM cord-331066-ediowz4s 279 19 2.2 2.2 CD cord-331066-ediowz4s 279 20 Â â CD cord-331066-ediowz4s 279 21 10 10 CD cord-331066-ediowz4s 279 22 3 3 CD cord-331066-ediowz4s 279 23 N n CD cord-331066-ediowz4s 279 24 proteins protein NNS cord-331066-ediowz4s 279 25 per per IN cord-331066-ediowz4s 279 26 virion virion NN cord-331066-ediowz4s 279 27 and and CC cord-331066-ediowz4s 279 28 the the DT cord-331066-ediowz4s 279 29 association association NN cord-331066-ediowz4s 279 30 of of IN cord-331066-ediowz4s 279 31 each each DT cord-331066-ediowz4s 279 32 N N NNP cord-331066-ediowz4s 279 33 protein protein NN cord-331066-ediowz4s 279 34 with with IN cord-331066-ediowz4s 279 35 14 14 CD cord-331066-ediowz4s 279 36 - - SYM cord-331066-ediowz4s 279 37 40 40 CD cord-331066-ediowz4s 279 38 nt nt NN cord-331066-ediowz4s 279 39 of of IN cord-331066-ediowz4s 279 40 genomic genomic JJ cord-331066-ediowz4s 279 41 RNA RNA NNP cord-331066-ediowz4s 279 42 . . . cord-331066-ediowz4s 280 1 The the DT cord-331066-ediowz4s 280 2 flower flower NN cord-331066-ediowz4s 280 3 - - HYPH cord-331066-ediowz4s 280 4 like like JJ cord-331066-ediowz4s 280 5 packaging packaging NN cord-331066-ediowz4s 280 6 of of IN cord-331066-ediowz4s 280 7 the the DT cord-331066-ediowz4s 280 8 helical helical JJ cord-331066-ediowz4s 280 9 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 280 10 within within IN cord-331066-ediowz4s 280 11 the the DT cord-331066-ediowz4s 280 12 envelope envelope NN cord-331066-ediowz4s 280 13 ( ( -LRB- cord-331066-ediowz4s 280 14 see see UH cord-331066-ediowz4s 280 15 , , , cord-331066-ediowz4s 280 16 e.g. e.g. RB cord-331066-ediowz4s 280 17 Gui Gui NNP cord-331066-ediowz4s 280 18 et et FW cord-331066-ediowz4s 280 19 al al NNP cord-331066-ediowz4s 280 20 . . NNP cord-331066-ediowz4s 280 21 , , , cord-331066-ediowz4s 280 22 2017 2017 CD cord-331066-ediowz4s 280 23 ; ; : cord-331066-ediowz4s 280 24 Masters master NNS cord-331066-ediowz4s 280 25 , , , cord-331066-ediowz4s 280 26 2019 2019 CD cord-331066-ediowz4s 280 27 ; ; : cord-331066-ediowz4s 280 28 and and CC cord-331066-ediowz4s 280 29 further further JJ cord-331066-ediowz4s 280 30 references reference NNS cord-331066-ediowz4s 280 31 therein therein RB cord-331066-ediowz4s 280 32 ) ) -RRB- cord-331066-ediowz4s 280 33 implies imply VBZ cord-331066-ediowz4s 280 34 an an DT cord-331066-ediowz4s 280 35 integrity integrity NN cord-331066-ediowz4s 280 36 of of IN cord-331066-ediowz4s 280 37 the the DT cord-331066-ediowz4s 280 38 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 280 39 and and CC cord-331066-ediowz4s 280 40 gives give VBZ cord-331066-ediowz4s 280 41 evidence evidence NN cord-331066-ediowz4s 280 42 against against IN cord-331066-ediowz4s 280 43 rods rod NNS cord-331066-ediowz4s 280 44 - - HYPH cord-331066-ediowz4s 280 45 on on IN cord-331066-ediowz4s 280 46 - - HYPH cord-331066-ediowz4s 280 47 a a DT cord-331066-ediowz4s 280 48 - - HYPH cord-331066-ediowz4s 280 49 string string NN cord-331066-ediowz4s 280 50 model model NN cord-331066-ediowz4s 280 51 for for IN cord-331066-ediowz4s 280 52 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 280 53 . . . cord-331066-ediowz4s 281 1 Therefore therefore RB cord-331066-ediowz4s 281 2 , , , cord-331066-ediowz4s 281 3 such such JJ cord-331066-ediowz4s 281 4 difference difference NN cord-331066-ediowz4s 281 5 in in IN cord-331066-ediowz4s 281 6 estimates estimate NNS cord-331066-ediowz4s 281 7 can can MD cord-331066-ediowz4s 281 8 not not RB cord-331066-ediowz4s 281 9 be be VB cord-331066-ediowz4s 281 10 attributed attribute VBN cord-331066-ediowz4s 281 11 to to IN cord-331066-ediowz4s 281 12 uncovering uncover VBG cord-331066-ediowz4s 281 13 of of IN cord-331066-ediowz4s 281 14 a a DT cord-331066-ediowz4s 281 15 part part NN cord-331066-ediowz4s 281 16 of of IN cord-331066-ediowz4s 281 17 the the DT cord-331066-ediowz4s 281 18 genome genome NN cord-331066-ediowz4s 281 19 . . . cord-331066-ediowz4s 282 1 Presumably presumably RB cord-331066-ediowz4s 282 2 , , , cord-331066-ediowz4s 282 3 the the DT cord-331066-ediowz4s 282 4 total total JJ cord-331066-ediowz4s 282 5 number number NN cord-331066-ediowz4s 282 6 of of IN cord-331066-ediowz4s 282 7 N n CD cord-331066-ediowz4s 282 8 proteins protein NNS cord-331066-ediowz4s 282 9 per per IN cord-331066-ediowz4s 282 10 virion virion NN cord-331066-ediowz4s 282 11 is be VBZ cord-331066-ediowz4s 282 12 underestimated underestimate VBN cord-331066-ediowz4s 282 13 and and CC cord-331066-ediowz4s 282 14 the the DT cord-331066-ediowz4s 282 15 number number NN cord-331066-ediowz4s 282 16 4.4 4.4 CD cord-331066-ediowz4s 282 17 Â â CD cord-331066-ediowz4s 282 18 10 10 CD cord-331066-ediowz4s 282 19 3 3 CD cord-331066-ediowz4s 282 20 makes make VBZ cord-331066-ediowz4s 282 21 N n CD cord-331066-ediowz4s 282 22 proteins protein NNS cord-331066-ediowz4s 282 23 the the DT cord-331066-ediowz4s 282 24 most most RBS cord-331066-ediowz4s 282 25 abundant abundant JJ cord-331066-ediowz4s 282 26 in in IN cord-331066-ediowz4s 282 27 the the DT cord-331066-ediowz4s 282 28 active active JJ cord-331066-ediowz4s 282 29 phase phase NN cord-331066-ediowz4s 282 30 of of IN cord-331066-ediowz4s 282 31 the the DT cord-331066-ediowz4s 282 32 virus virus NN cord-331066-ediowz4s 282 33 life life NN cord-331066-ediowz4s 282 34 cycle cycle NN cord-331066-ediowz4s 282 35 . . . cord-331066-ediowz4s 283 1 N n CD cord-331066-ediowz4s 283 2 proteins protein NNS cord-331066-ediowz4s 283 3 of of IN cord-331066-ediowz4s 283 4 the the DT cord-331066-ediowz4s 283 5 coronaviruses coronaviruse NNS cord-331066-ediowz4s 283 6 provide provide VBP cord-331066-ediowz4s 283 7 the the DT cord-331066-ediowz4s 283 8 promising promising JJ cord-331066-ediowz4s 283 9 therapeutic therapeutic JJ cord-331066-ediowz4s 283 10 targets target NNS cord-331066-ediowz4s 283 11 ( ( -LRB- cord-331066-ediowz4s 283 12 Chang Chang NNP cord-331066-ediowz4s 283 13 et et NNP cord-331066-ediowz4s 283 14 al al NNP cord-331066-ediowz4s 283 15 . . NNP cord-331066-ediowz4s 283 16 , , , cord-331066-ediowz4s 283 17 2014 2014 CD cord-331066-ediowz4s 283 18 ; ; . cord-331066-ediowz4s 284 1 Lin Lin NNP cord-331066-ediowz4s 284 2 et et NNP cord-331066-ediowz4s 284 3 al al NNP cord-331066-ediowz4s 284 4 . . . cord-331066-ediowz4s 285 1 , , , cord-331066-ediowz4s 285 2 2020 2020 CD cord-331066-ediowz4s 285 3 ; ; : cord-331066-ediowz4s 285 4 Tilocca Tilocca NNP cord-331066-ediowz4s 285 5 et et NNP cord-331066-ediowz4s 285 6 al al NNP cord-331066-ediowz4s 285 7 . . NNP cord-331066-ediowz4s 285 8 , , , cord-331066-ediowz4s 285 9 2020 2020 CD cord-331066-ediowz4s 286 1 ; ; : cord-331066-ediowz4s 286 2 Yadav Yadav NNP cord-331066-ediowz4s 286 3 et et NNP cord-331066-ediowz4s 286 4 al al NNP cord-331066-ediowz4s 286 5 . . NNP cord-331066-ediowz4s 286 6 , , , cord-331066-ediowz4s 286 7 2020 2020 CD cord-331066-ediowz4s 286 8 ) ) -RRB- cord-331066-ediowz4s 286 9 . . . cord-331066-ediowz4s 287 1 The the DT cord-331066-ediowz4s 287 2 advantages advantage NNS cord-331066-ediowz4s 287 3 of of IN cord-331066-ediowz4s 287 4 using use VBG cord-331066-ediowz4s 287 5 N n CD cord-331066-ediowz4s 287 6 proteins protein NNS cord-331066-ediowz4s 287 7 for for IN cord-331066-ediowz4s 287 8 therapeutic therapeutic JJ cord-331066-ediowz4s 287 9 targeting targeting NN cord-331066-ediowz4s 287 10 are be VBP cord-331066-ediowz4s 287 11 as as IN cord-331066-ediowz4s 287 12 follows follow NNS cord-331066-ediowz4s 287 13 . . . cord-331066-ediowz4s 288 1 ( ( -LRB- cord-331066-ediowz4s 288 2 i i NN cord-331066-ediowz4s 288 3 ) ) -RRB- cord-331066-ediowz4s 289 1 As as IN cord-331066-ediowz4s 289 2 N n CD cord-331066-ediowz4s 289 3 proteins protein NNS cord-331066-ediowz4s 289 4 are be VBP cord-331066-ediowz4s 289 5 abundant abundant JJ cord-331066-ediowz4s 289 6 , , , cord-331066-ediowz4s 289 7 the the DT cord-331066-ediowz4s 289 8 antibodies antibody NNS cord-331066-ediowz4s 289 9 against against IN cord-331066-ediowz4s 289 10 them -PRON- PRP cord-331066-ediowz4s 289 11 can can MD cord-331066-ediowz4s 289 12 be be VB cord-331066-ediowz4s 289 13 used use VBN cord-331066-ediowz4s 289 14 for for IN cord-331066-ediowz4s 289 15 early early JJ cord-331066-ediowz4s 289 16 diagnostics diagnostic NNS cord-331066-ediowz4s 289 17 and and CC cord-331066-ediowz4s 289 18 in in IN cord-331066-ediowz4s 289 19 vaccines vaccine NNS cord-331066-ediowz4s 289 20 . . . cord-331066-ediowz4s 290 1 ( ( -LRB- cord-331066-ediowz4s 290 2 ii ii NN cord-331066-ediowz4s 290 3 ) ) -RRB- cord-331066-ediowz4s 290 4 N n CD cord-331066-ediowz4s 290 5 proteins protein NNS cord-331066-ediowz4s 290 6 are be VBP cord-331066-ediowz4s 290 7 multifunctional multifunctional JJ cord-331066-ediowz4s 290 8 and and CC cord-331066-ediowz4s 290 9 participate participate VBP cord-331066-ediowz4s 290 10 not not RB cord-331066-ediowz4s 290 11 only only RB cord-331066-ediowz4s 290 12 in in IN cord-331066-ediowz4s 290 13 the the DT cord-331066-ediowz4s 290 14 assembly/ assembly/ JJS cord-331066-ediowz4s 290 15 packaging packaging NN cord-331066-ediowz4s 290 16 of of IN cord-331066-ediowz4s 290 17 the the DT cord-331066-ediowz4s 290 18 ribonucleocapsid ribonucleocapsid NNP cord-331066-ediowz4s 290 19 but but CC cord-331066-ediowz4s 290 20 also also RB cord-331066-ediowz4s 290 21 in in IN cord-331066-ediowz4s 290 22 the the DT cord-331066-ediowz4s 290 23 regulation regulation NN cord-331066-ediowz4s 290 24 of of IN cord-331066-ediowz4s 290 25 the the DT cord-331066-ediowz4s 290 26 replication replication NN cord-331066-ediowz4s 290 27 - - HYPH cord-331066-ediowz4s 290 28 transcription transcription NN cord-331066-ediowz4s 290 29 processes process NNS cord-331066-ediowz4s 290 30 ( ( -LRB- cord-331066-ediowz4s 290 31 Hurst Hurst NNP cord-331066-ediowz4s 290 32 et et NNP cord-331066-ediowz4s 290 33 al al NNP cord-331066-ediowz4s 290 34 . . NNP cord-331066-ediowz4s 290 35 , , , cord-331066-ediowz4s 290 36 2010 2010 CD cord-331066-ediowz4s 291 1 ; ; : cord-331066-ediowz4s 291 2 McBride McBride NNP cord-331066-ediowz4s 291 3 et et NNP cord-331066-ediowz4s 291 4 al al NNP cord-331066-ediowz4s 291 5 . . . cord-331066-ediowz4s 292 1 , , , cord-331066-ediowz4s 292 2 2014 2014 CD cord-331066-ediowz4s 292 3 ; ; : cord-331066-ediowz4s 292 4 Verheije Verheije NNP cord-331066-ediowz4s 292 5 et et FW cord-331066-ediowz4s 292 6 al al NNP cord-331066-ediowz4s 292 7 . . NNP cord-331066-ediowz4s 292 8 , , , cord-331066-ediowz4s 292 9 2010 2010 CD cord-331066-ediowz4s 292 10 ) ) -RRB- cord-331066-ediowz4s 292 11 . . . cord-331066-ediowz4s 293 1 The the DT cord-331066-ediowz4s 293 2 interaction interaction NN cord-331066-ediowz4s 293 3 between between IN cord-331066-ediowz4s 293 4 M M NNP cord-331066-ediowz4s 293 5 and and CC cord-331066-ediowz4s 293 6 N n CD cord-331066-ediowz4s 293 7 proteins protein NNS cord-331066-ediowz4s 293 8 plays play VBZ cord-331066-ediowz4s 293 9 an an DT cord-331066-ediowz4s 293 10 important important JJ cord-331066-ediowz4s 293 11 role role NN cord-331066-ediowz4s 293 12 in in IN cord-331066-ediowz4s 293 13 the the DT cord-331066-ediowz4s 293 14 packaging packaging NN cord-331066-ediowz4s 293 15 of of IN cord-331066-ediowz4s 293 16 the the DT cord-331066-ediowz4s 293 17 ribonucleocapsid ribonucleocapsid NN cord-331066-ediowz4s 293 18 within within IN cord-331066-ediowz4s 293 19 the the DT cord-331066-ediowz4s 293 20 envelope envelope NN cord-331066-ediowz4s 293 21 ( ( -LRB- cord-331066-ediowz4s 293 22 Kuo Kuo NNP cord-331066-ediowz4s 293 23 et et NNP cord-331066-ediowz4s 293 24 al al NNP cord-331066-ediowz4s 293 25 . . NNP cord-331066-ediowz4s 293 26 , , , cord-331066-ediowz4s 293 27 2016 2016 CD cord-331066-ediowz4s 293 28 ) ) -RRB- cord-331066-ediowz4s 293 29 . . . cord-331066-ediowz4s 294 1 ( ( -LRB- cord-331066-ediowz4s 294 2 iii iii NN cord-331066-ediowz4s 294 3 ) ) -RRB- cord-331066-ediowz4s 294 4 Coronavirus Coronavirus NNP cord-331066-ediowz4s 294 5 M M NNP cord-331066-ediowz4s 294 6 and and CC cord-331066-ediowz4s 294 7 N n CD cord-331066-ediowz4s 294 8 proteins protein NNS cord-331066-ediowz4s 294 9 stand stand VBP cord-331066-ediowz4s 294 10 out out RP cord-331066-ediowz4s 294 11 as as IN cord-331066-ediowz4s 294 12 being be VBG cord-331066-ediowz4s 294 13 the the DT cord-331066-ediowz4s 294 14 most most RBS cord-331066-ediowz4s 294 15 conserved conserve VBN cord-331066-ediowz4s 294 16 among among IN cord-331066-ediowz4s 294 17 structural structural JJ cord-331066-ediowz4s 294 18 proteins protein NNS cord-331066-ediowz4s 294 19 ( ( -LRB- cord-331066-ediowz4s 294 20 Neuman Neuman NNP cord-331066-ediowz4s 294 21 & & CC cord-331066-ediowz4s 294 22 Buchmeier Buchmeier NNP cord-331066-ediowz4s 294 23 , , , cord-331066-ediowz4s 294 24 2016 2016 CD cord-331066-ediowz4s 294 25 ) ) -RRB- cord-331066-ediowz4s 294 26 . . . cord-331066-ediowz4s 295 1 They -PRON- PRP cord-331066-ediowz4s 295 2 should should MD cord-331066-ediowz4s 295 3 be be VB cord-331066-ediowz4s 295 4 more more RBR cord-331066-ediowz4s 295 5 stable stable JJ cord-331066-ediowz4s 295 6 against against IN cord-331066-ediowz4s 295 7 the the DT cord-331066-ediowz4s 295 8 load load NN cord-331066-ediowz4s 295 9 from from IN cord-331066-ediowz4s 295 10 point point NN cord-331066-ediowz4s 295 11 mutations mutation NNS cord-331066-ediowz4s 295 12 and and CC cord-331066-ediowz4s 295 13 indels indel NNS cord-331066-ediowz4s 295 14 especially especially RB cord-331066-ediowz4s 295 15 frequent frequent JJ cord-331066-ediowz4s 295 16 in in IN cord-331066-ediowz4s 295 17 viruses virus NNS cord-331066-ediowz4s 295 18 . . . cord-331066-ediowz4s 296 1 The the DT cord-331066-ediowz4s 296 2 most most JJS cord-331066-ediowz4s 296 3 of of IN cord-331066-ediowz4s 296 4 vaccines vaccine NNS cord-331066-ediowz4s 296 5 are be VBP cord-331066-ediowz4s 296 6 currently currently RB cord-331066-ediowz4s 296 7 developed develop VBN cord-331066-ediowz4s 296 8 against against IN cord-331066-ediowz4s 296 9 spike spike NN cord-331066-ediowz4s 296 10 ( ( -LRB- cord-331066-ediowz4s 296 11 S s NN cord-331066-ediowz4s 296 12 ) ) -RRB- cord-331066-ediowz4s 296 13 proteins protein NNS cord-331066-ediowz4s 296 14 . . . cord-331066-ediowz4s 297 1 However however RB cord-331066-ediowz4s 297 2 , , , cord-331066-ediowz4s 297 3 S s NN cord-331066-ediowz4s 297 4 proteins protein NNS cord-331066-ediowz4s 297 5 are be VBP cord-331066-ediowz4s 297 6 rather rather RB cord-331066-ediowz4s 297 7 variable variable JJ cord-331066-ediowz4s 297 8 and and CC cord-331066-ediowz4s 297 9 in in IN cord-331066-ediowz4s 297 10 any any DT cord-331066-ediowz4s 297 11 case case NN cord-331066-ediowz4s 297 12 the the DT cord-331066-ediowz4s 297 13 multitargeted multitargete VBN cord-331066-ediowz4s 297 14 vaccines vaccine NNS cord-331066-ediowz4s 297 15 will will MD cord-331066-ediowz4s 297 16 be be VB cord-331066-ediowz4s 297 17 more more RBR cord-331066-ediowz4s 297 18 efficient efficient JJ cord-331066-ediowz4s 297 19 in in IN cord-331066-ediowz4s 297 20 comparison comparison NN cord-331066-ediowz4s 297 21 with with IN cord-331066-ediowz4s 297 22 one one CD cord-331066-ediowz4s 297 23 - - HYPH cord-331066-ediowz4s 297 24 targeted target VBN cord-331066-ediowz4s 297 25 . . . cord-331066-ediowz4s 298 1 The the DT cord-331066-ediowz4s 298 2 other other JJ cord-331066-ediowz4s 298 3 strategy strategy NN cord-331066-ediowz4s 298 4 is be VBZ cord-331066-ediowz4s 298 5 related relate VBN cord-331066-ediowz4s 298 6 to to IN cord-331066-ediowz4s 298 7 the the DT cord-331066-ediowz4s 298 8 development development NN cord-331066-ediowz4s 298 9 of of IN cord-331066-ediowz4s 298 10 RNA RNA NNP cord-331066-ediowz4s 298 11 vaccines vaccine NNS cord-331066-ediowz4s 298 12 ( ( -LRB- cord-331066-ediowz4s 298 13 Kramps Kramps NNP cord-331066-ediowz4s 298 14 & & CC cord-331066-ediowz4s 298 15 Elbers Elbers NNP cord-331066-ediowz4s 298 16 , , , cord-331066-ediowz4s 298 17 2017 2017 CD cord-331066-ediowz4s 298 18 ) ) -RRB- cord-331066-ediowz4s 298 19 or or CC cord-331066-ediowz4s 298 20 to to IN cord-331066-ediowz4s 298 21 targeting target VBG cord-331066-ediowz4s 298 22 of of IN cord-331066-ediowz4s 298 23 specific specific JJ cord-331066-ediowz4s 298 24 motifs motif NNS cord-331066-ediowz4s 298 25 in in IN cord-331066-ediowz4s 298 26 the the DT cord-331066-ediowz4s 298 27 viral viral JJ cord-331066-ediowz4s 298 28 RNA RNA NNP cord-331066-ediowz4s 298 29 . . . cord-331066-ediowz4s 299 1 The the DT cord-331066-ediowz4s 299 2 latter latter JJ cord-331066-ediowz4s 299 3 can can MD cord-331066-ediowz4s 299 4 be be VB cord-331066-ediowz4s 299 5 performed perform VBN cord-331066-ediowz4s 299 6 by by IN cord-331066-ediowz4s 299 7 RNA RNA NNP cord-331066-ediowz4s 299 8 aptamers aptamers NNP cord-331066-ediowz4s 299 9 , , , cord-331066-ediowz4s 299 10 RNA RNA NNP cord-331066-ediowz4s 299 11 interference interference NN cord-331066-ediowz4s 299 12 ( ( -LRB- cord-331066-ediowz4s 299 13 Min Min NNP cord-331066-ediowz4s 299 14 & & CC cord-331066-ediowz4s 299 15 Ichim Ichim NNP cord-331066-ediowz4s 299 16 , , , cord-331066-ediowz4s 299 17 2010 2010 CD cord-331066-ediowz4s 299 18 ) ) -RRB- cord-331066-ediowz4s 299 19 or or CC cord-331066-ediowz4s 299 20 by by IN cord-331066-ediowz4s 299 21 the the DT cord-331066-ediowz4s 299 22 specially specially RB cord-331066-ediowz4s 299 23 designed design VBN cord-331066-ediowz4s 299 24 RNA rna NN cord-331066-ediowz4s 299 25 - - HYPH cord-331066-ediowz4s 299 26 binding bind VBG cord-331066-ediowz4s 299 27 proteins protein NNS cord-331066-ediowz4s 299 28 ( ( -LRB- cord-331066-ediowz4s 299 29 Filipovska Filipovska NNP cord-331066-ediowz4s 299 30 & & CC cord-331066-ediowz4s 299 31 Rackham Rackham NNP cord-331066-ediowz4s 299 32 , , , cord-331066-ediowz4s 299 33 2012 2012 CD cord-331066-ediowz4s 299 34 ; ; : cord-331066-ediowz4s 299 35 Hall Hall NNP cord-331066-ediowz4s 299 36 , , , cord-331066-ediowz4s 299 37 2016 2016 CD cord-331066-ediowz4s 299 38 ; ; : cord-331066-ediowz4s 299 39 Lunde Lunde NNP cord-331066-ediowz4s 299 40 et et FW cord-331066-ediowz4s 299 41 al al NNP cord-331066-ediowz4s 299 42 . . NNP cord-331066-ediowz4s 299 43 , , , cord-331066-ediowz4s 299 44 2007 2007 CD cord-331066-ediowz4s 299 45 ) ) -RRB- cord-331066-ediowz4s 299 46 . . . cord-331066-ediowz4s 300 1 The the DT cord-331066-ediowz4s 300 2 assembly/ assembly/ CD cord-331066-ediowz4s 300 3 packaging packaging NN cord-331066-ediowz4s 300 4 signals signal NNS cord-331066-ediowz4s 300 5 look look VBP cord-331066-ediowz4s 300 6 quite quite RB cord-331066-ediowz4s 300 7 promising promising JJ cord-331066-ediowz4s 300 8 as as IN cord-331066-ediowz4s 300 9 the the DT cord-331066-ediowz4s 300 10 targets target NNS cord-331066-ediowz4s 300 11 in in IN cord-331066-ediowz4s 300 12 the the DT cord-331066-ediowz4s 300 13 genomic genomic NN cord-331066-ediowz4s 300 14 ssRNA ssrna NN cord-331066-ediowz4s 300 15 . . . cord-331066-ediowz4s 301 1 The the DT cord-331066-ediowz4s 301 2 modified modified JJ cord-331066-ediowz4s 301 3 N n CD cord-331066-ediowz4s 301 4 proteins protein NNS cord-331066-ediowz4s 301 5 or or CC cord-331066-ediowz4s 301 6 their -PRON- PRP$ cord-331066-ediowz4s 301 7 fragments fragment NNS cord-331066-ediowz4s 301 8 can can MD cord-331066-ediowz4s 301 9 be be VB cord-331066-ediowz4s 301 10 used use VBN cord-331066-ediowz4s 301 11 for for IN cord-331066-ediowz4s 301 12 similar similar JJ cord-331066-ediowz4s 301 13 purposes purpose NNS cord-331066-ediowz4s 301 14 and and CC cord-331066-ediowz4s 301 15 may may MD cord-331066-ediowz4s 301 16 introduce introduce VB cord-331066-ediowz4s 301 17 defects defect NNS cord-331066-ediowz4s 301 18 in in IN cord-331066-ediowz4s 301 19 the the DT cord-331066-ediowz4s 301 20 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 301 21 and and CC cord-331066-ediowz4s 301 22 make make VB cord-331066-ediowz4s 301 23 the the DT cord-331066-ediowz4s 301 24 virus virus NN cord-331066-ediowz4s 301 25 less less RBR cord-331066-ediowz4s 301 26 viable viable JJ cord-331066-ediowz4s 301 27 . . . cord-331066-ediowz4s 302 1 The the DT cord-331066-ediowz4s 302 2 incorporation incorporation NN cord-331066-ediowz4s 302 3 of of IN cord-331066-ediowz4s 302 4 assembly assembly NN cord-331066-ediowz4s 302 5 / / SYM cord-331066-ediowz4s 302 6 packaging packaging NN cord-331066-ediowz4s 302 7 motifs motif NNS cord-331066-ediowz4s 302 8 into into IN cord-331066-ediowz4s 302 9 oligonucleotides oligonucleotide NNS cord-331066-ediowz4s 302 10 immobilized immobilize VBN cord-331066-ediowz4s 302 11 on on IN cord-331066-ediowz4s 302 12 the the DT cord-331066-ediowz4s 302 13 surface surface NN cord-331066-ediowz4s 302 14 of of IN cord-331066-ediowz4s 302 15 microarrays microarray NNS cord-331066-ediowz4s 302 16 may may MD cord-331066-ediowz4s 302 17 facilitate facilitate VB cord-331066-ediowz4s 302 18 the the DT cord-331066-ediowz4s 302 19 detection detection NN cord-331066-ediowz4s 302 20 of of IN cord-331066-ediowz4s 302 21 coronaviruses coronaviruse NNS cord-331066-ediowz4s 302 22 by by IN cord-331066-ediowz4s 302 23 microarrays microarray NNS cord-331066-ediowz4s 302 24 ( ( -LRB- cord-331066-ediowz4s 302 25 for for IN cord-331066-ediowz4s 302 26 a a DT cord-331066-ediowz4s 302 27 review review NN cord-331066-ediowz4s 302 28 on on IN cord-331066-ediowz4s 302 29 microarrays microarray NNS cord-331066-ediowz4s 302 30 see see VBP cord-331066-ediowz4s 302 31 , , , cord-331066-ediowz4s 302 32 e.g. e.g. RB cord-331066-ediowz4s 302 33 Dufva Dufva NNP cord-331066-ediowz4s 302 34 , , , cord-331066-ediowz4s 302 35 2009 2009 CD cord-331066-ediowz4s 302 36 ) ) -RRB- cord-331066-ediowz4s 302 37 . . . cord-331066-ediowz4s 303 1 Presumably presumably RB cord-331066-ediowz4s 303 2 , , , cord-331066-ediowz4s 303 3 the the DT cord-331066-ediowz4s 303 4 most most RBS cord-331066-ediowz4s 303 5 working working NN cord-331066-ediowz4s 303 6 motifs motif NNS cord-331066-ediowz4s 303 7 ( ( -LRB- cord-331066-ediowz4s 303 8 or or CC cord-331066-ediowz4s 303 9 , , , cord-331066-ediowz4s 303 10 more more RBR cord-331066-ediowz4s 303 11 exactly exactly RB cord-331066-ediowz4s 303 12 , , , cord-331066-ediowz4s 303 13 the the DT cord-331066-ediowz4s 303 14 complete complete JJ cord-331066-ediowz4s 303 15 words word NNS cord-331066-ediowz4s 303 16 defined define VBN cord-331066-ediowz4s 303 17 in in IN cord-331066-ediowz4s 303 18 Subsection Subsection NNP cord-331066-ediowz4s 303 19 2.4 2.4 CD cord-331066-ediowz4s 303 20 ) ) -RRB- cord-331066-ediowz4s 303 21 participating participate VBG cord-331066-ediowz4s 303 22 in in IN cord-331066-ediowz4s 303 23 ssRNA ssrna JJ cord-331066-ediowz4s 303 24 - - HYPH cord-331066-ediowz4s 303 25 N n NN cord-331066-ediowz4s 303 26 proteins protein NNS cord-331066-ediowz4s 303 27 specific specific JJ cord-331066-ediowz4s 303 28 interactions interaction NNS cord-331066-ediowz4s 303 29 are be VBP cord-331066-ediowz4s 303 30 of of IN cord-331066-ediowz4s 303 31 2 2 CD cord-331066-ediowz4s 303 32 - - SYM cord-331066-ediowz4s 303 33 4 4 CD cord-331066-ediowz4s 303 34 nt nt RB cord-331066-ediowz4s 303 35 in in IN cord-331066-ediowz4s 303 36 length length NN cord-331066-ediowz4s 303 37 . . . cord-331066-ediowz4s 304 1 They -PRON- PRP cord-331066-ediowz4s 304 2 are be VBP cord-331066-ediowz4s 304 3 frequent frequent JJ cord-331066-ediowz4s 304 4 enough enough RB cord-331066-ediowz4s 304 5 ( ( -LRB- cord-331066-ediowz4s 304 6 see see VB cord-331066-ediowz4s 304 7 Table table NN cord-331066-ediowz4s 304 8 2 2 CD cord-331066-ediowz4s 304 9 ) ) -RRB- cord-331066-ediowz4s 304 10 and and CC cord-331066-ediowz4s 304 11 their -PRON- PRP$ cord-331066-ediowz4s 304 12 coordinate coordinate JJ cord-331066-ediowz4s 304 13 positioning positioning NN cord-331066-ediowz4s 304 14 over over IN cord-331066-ediowz4s 304 15 the the DT cord-331066-ediowz4s 304 16 genome genome NN cord-331066-ediowz4s 304 17 may may MD cord-331066-ediowz4s 304 18 provide provide VB cord-331066-ediowz4s 304 19 specific specific JJ cord-331066-ediowz4s 304 20 cooperative cooperative JJ cord-331066-ediowz4s 304 21 interaction interaction NN cord-331066-ediowz4s 304 22 with with IN cord-331066-ediowz4s 304 23 N n CD cord-331066-ediowz4s 304 24 proteins protein NNS cord-331066-ediowz4s 304 25 . . . cord-331066-ediowz4s 305 1 The the DT cord-331066-ediowz4s 305 2 close close JJ cord-331066-ediowz4s 305 3 incorporation incorporation NN cord-331066-ediowz4s 305 4 of of IN cord-331066-ediowz4s 305 5 the the DT cord-331066-ediowz4s 305 6 longer long JJR cord-331066-ediowz4s 305 7 motifs motif NNS cord-331066-ediowz4s 305 8 would would MD cord-331066-ediowz4s 305 9 be be VB cord-331066-ediowz4s 305 10 too too RB cord-331066-ediowz4s 305 11 restrictive restrictive JJ cord-331066-ediowz4s 305 12 because because IN cord-331066-ediowz4s 305 13 of of IN cord-331066-ediowz4s 305 14 the the DT cord-331066-ediowz4s 305 15 protein protein NN cord-331066-ediowz4s 305 16 coding coding NN cord-331066-ediowz4s 305 17 function function NN cord-331066-ediowz4s 305 18 of of IN cord-331066-ediowz4s 305 19 the the DT cord-331066-ediowz4s 305 20 genomic genomic NN cord-331066-ediowz4s 305 21 ssRNA ssrna NN cord-331066-ediowz4s 305 22 . . . cord-331066-ediowz4s 306 1 However however RB cord-331066-ediowz4s 306 2 , , , cord-331066-ediowz4s 306 3 the the DT cord-331066-ediowz4s 306 4 longer long JJR cord-331066-ediowz4s 306 5 and and CC cord-331066-ediowz4s 306 6 rarer rare JJR cord-331066-ediowz4s 306 7 motifs motif NNS cord-331066-ediowz4s 306 8 may may MD cord-331066-ediowz4s 306 9 be be VB cord-331066-ediowz4s 306 10 multifunctional multifunctional JJ cord-331066-ediowz4s 306 11 and and CC cord-331066-ediowz4s 306 12 may may MD cord-331066-ediowz4s 306 13 play play VB cord-331066-ediowz4s 306 14 The the DT cord-331066-ediowz4s 306 15 standard standard JJ cord-331066-ediowz4s 306 16 deviations deviation NNS cord-331066-ediowz4s 306 17 for for IN cord-331066-ediowz4s 306 18 the the DT cord-331066-ediowz4s 306 19 relative relative JJ cord-331066-ediowz4s 306 20 spectral spectral JJ cord-331066-ediowz4s 306 21 entropies entropy NNS cord-331066-ediowz4s 306 22 S S NNP cord-331066-ediowz4s 306 23 a a NN cord-331066-ediowz4s 306 24 , , , cord-331066-ediowz4s 306 25 rel rel NNP cord-331066-ediowz4s 306 26 in in IN cord-331066-ediowz4s 306 27 the the DT cord-331066-ediowz4s 306 28 random random JJ cord-331066-ediowz4s 306 29 sequences sequence NNS cord-331066-ediowz4s 306 30 of of IN cord-331066-ediowz4s 306 31 the the DT cord-331066-ediowz4s 306 32 same same JJ cord-331066-ediowz4s 306 33 lengths length NNS cord-331066-ediowz4s 306 34 are be VBP cord-331066-ediowz4s 306 35 about about RB cord-331066-ediowz4s 306 36 0.010 0.010 CD cord-331066-ediowz4s 306 37 . . . cord-331066-ediowz4s 307 1 The the DT cord-331066-ediowz4s 307 2 standard standard JJ cord-331066-ediowz4s 307 3 deviation deviation NN cord-331066-ediowz4s 307 4 for for IN cord-331066-ediowz4s 307 5 S S NNP cord-331066-ediowz4s 307 6 total total NN cord-331066-ediowz4s 307 7 , , , cord-331066-ediowz4s 307 8 rel rel NNP cord-331066-ediowz4s 307 9 is be VBZ cord-331066-ediowz4s 307 10 twice twice RB cord-331066-ediowz4s 307 11 of of IN cord-331066-ediowz4s 307 12 this this DT cord-331066-ediowz4s 307 13 value value NN cord-331066-ediowz4s 307 14 . . . cord-331066-ediowz4s 308 1 the the DT cord-331066-ediowz4s 308 2 role role NN cord-331066-ediowz4s 308 3 of of IN cord-331066-ediowz4s 308 4 cis cis NNP cord-331066-ediowz4s 308 5 / / SYM cord-331066-ediowz4s 308 6 trans trans NNP cord-331066-ediowz4s 308 7 - - NNS cord-331066-ediowz4s 308 8 elements element NNS cord-331066-ediowz4s 308 9 for for IN cord-331066-ediowz4s 308 10 other other JJ cord-331066-ediowz4s 308 11 molecular molecular JJ cord-331066-ediowz4s 308 12 mechanisms mechanism NNS cord-331066-ediowz4s 308 13 during during IN cord-331066-ediowz4s 308 14 the the DT cord-331066-ediowz4s 308 15 virus virus NN cord-331066-ediowz4s 308 16 life life NN cord-331066-ediowz4s 308 17 cycle cycle NN cord-331066-ediowz4s 308 18 . . . cord-331066-ediowz4s 309 1 This this DT cord-331066-ediowz4s 309 2 conclusion conclusion NN cord-331066-ediowz4s 309 3 looks look VBZ cord-331066-ediowz4s 309 4 nearly nearly RB cord-331066-ediowz4s 309 5 definite definite JJ cord-331066-ediowz4s 309 6 for for IN cord-331066-ediowz4s 309 7 the the DT cord-331066-ediowz4s 309 8 pairwise pairwise JJ cord-331066-ediowz4s 309 9 motifs motif NNS cord-331066-ediowz4s 309 10 at at IN cord-331066-ediowz4s 309 11 the the DT cord-331066-ediowz4s 309 12 step step NN cord-331066-ediowz4s 309 13 s s NNP cord-331066-ediowz4s 309 14 ¼ ¼ NNP cord-331066-ediowz4s 309 15 84 84 CD cord-331066-ediowz4s 309 16 such such JJ cord-331066-ediowz4s 309 17 as as IN cord-331066-ediowz4s 309 18 ATTATAATTATAAAT ATTATAATTATAAAT NNP cord-331066-ediowz4s 309 19 ( ( -LRB- cord-331066-ediowz4s 309 20 SARS SARS NNP cord-331066-ediowz4s 309 21 - - HYPH cord-331066-ediowz4s 309 22 CoV CoV NNP cord-331066-ediowz4s 309 23 ; ; : cord-331066-ediowz4s 309 24 the the DT cord-331066-ediowz4s 309 25 start start NN cord-331066-ediowz4s 309 26 sites site NNS cord-331066-ediowz4s 309 27 22711 22711 CD cord-331066-ediowz4s 309 28 and and CC cord-331066-ediowz4s 309 29 22795 22795 CD cord-331066-ediowz4s 309 30 ) ) -RRB- cord-331066-ediowz4s 309 31 and and CC cord-331066-ediowz4s 309 32 ATTATAATTA ATTATAATTA NNP cord-331066-ediowz4s 309 33 ( ( -LRB- cord-331066-ediowz4s 309 34 isolates isolate NNS cord-331066-ediowz4s 309 35 of of IN cord-331066-ediowz4s 309 36 SARS SARS NNP cord-331066-ediowz4s 309 37 - - HYPH cord-331066-ediowz4s 309 38 CoV-2 CoV-2 NNP cord-331066-ediowz4s 309 39 ; ; : cord-331066-ediowz4s 309 40 sites site NNS cord-331066-ediowz4s 309 41 22766 22766 CD cord-331066-ediowz4s 309 42 and and CC cord-331066-ediowz4s 309 43 22850 22850 CD cord-331066-ediowz4s 309 44 ; ; : cord-331066-ediowz4s 309 45 22810 22810 CD cord-331066-ediowz4s 309 46 and and CC cord-331066-ediowz4s 309 47 22894 22894 CD cord-331066-ediowz4s 309 48 ; ; : cord-331066-ediowz4s 309 49 22757 22757 CD cord-331066-ediowz4s 309 50 and and CC cord-331066-ediowz4s 309 51 22841 22841 CD cord-331066-ediowz4s 309 52 , , , cord-331066-ediowz4s 309 53 respectively respectively RB cord-331066-ediowz4s 309 54 ) ) -RRB- cord-331066-ediowz4s 309 55 . . . cord-331066-ediowz4s 310 1 Note note VB cord-331066-ediowz4s 310 2 that that IN cord-331066-ediowz4s 310 3 the the DT cord-331066-ediowz4s 310 4 positions position NNS cord-331066-ediowz4s 310 5 of of IN cord-331066-ediowz4s 310 6 these these DT cord-331066-ediowz4s 310 7 motifs motif NNS cord-331066-ediowz4s 310 8 on on IN cord-331066-ediowz4s 310 9 the the DT cord-331066-ediowz4s 310 10 genomes genome NNS cord-331066-ediowz4s 310 11 are be VBP cord-331066-ediowz4s 310 12 also also RB cord-331066-ediowz4s 310 13 closely closely RB cord-331066-ediowz4s 310 14 conserved conserve VBN cord-331066-ediowz4s 310 15 . . . cord-331066-ediowz4s 311 1 The the DT cord-331066-ediowz4s 311 2 same same JJ cord-331066-ediowz4s 311 3 concerns concern NNS cord-331066-ediowz4s 311 4 the the DT cord-331066-ediowz4s 311 5 longest long JJS cord-331066-ediowz4s 311 6 motifs motif NNS cord-331066-ediowz4s 311 7 found find VBN cord-331066-ediowz4s 311 8 at at IN cord-331066-ediowz4s 311 9 s s NNP cord-331066-ediowz4s 311 10 ¼ ¼ NNP cord-331066-ediowz4s 311 11 54 54 CD cord-331066-ediowz4s 311 12 in in IN cord-331066-ediowz4s 311 13 the the DT cord-331066-ediowz4s 311 14 genome genome NN cord-331066-ediowz4s 311 15 of of IN cord-331066-ediowz4s 311 16 SARS SARS NNP cord-331066-ediowz4s 311 17 - - HYPH cord-331066-ediowz4s 311 18 CoV-2 CoV-2 NNP cord-331066-ediowz4s 311 19 , , , cord-331066-ediowz4s 311 20 TATTC TATTC NNP cord-331066-ediowz4s 311 21 AAACAATTGTTG AAACAATTGTTG NNP cord-331066-ediowz4s 311 22 ( ( -LRB- cord-331066-ediowz4s 311 23 sites site NNS cord-331066-ediowz4s 311 24 3213 3213 CD cord-331066-ediowz4s 311 25 , , , cord-331066-ediowz4s 311 26 3257 3257 CD cord-331066-ediowz4s 311 27 and and CC cord-331066-ediowz4s 311 28 3204 3204 CD cord-331066-ediowz4s 311 29 , , , cord-331066-ediowz4s 311 30 respectively respectively RB cord-331066-ediowz4s 311 31 ) ) -RRB- cord-331066-ediowz4s 311 32 . . . cord-331066-ediowz4s 312 1 The the DT cord-331066-ediowz4s 312 2 specific specific JJ cord-331066-ediowz4s 312 3 binding binding NN cord-331066-ediowz4s 312 4 of of IN cord-331066-ediowz4s 312 5 N n CD cord-331066-ediowz4s 312 6 proteins protein NNS cord-331066-ediowz4s 312 7 with with IN cord-331066-ediowz4s 312 8 ssRNA ssrna NN cord-331066-ediowz4s 312 9 results result NNS cord-331066-ediowz4s 312 10 in in IN cord-331066-ediowz4s 312 11 the the DT cord-331066-ediowz4s 312 12 lowering lowering NN cord-331066-ediowz4s 312 13 of of IN cord-331066-ediowz4s 312 14 free free JJ cord-331066-ediowz4s 312 15 energy energy NN cord-331066-ediowz4s 312 16 , , , cord-331066-ediowz4s 312 17 which which WDT cord-331066-ediowz4s 312 18 may may MD cord-331066-ediowz4s 312 19 approximately approximately RB cord-331066-ediowz4s 312 20 be be VB cord-331066-ediowz4s 312 21 assessed assess VBN cord-331066-ediowz4s 312 22 by by IN cord-331066-ediowz4s 312 23 the the DT cord-331066-ediowz4s 312 24 Boltzmann Boltzmann NNP cord-331066-ediowz4s 312 25 factor factor NN cord-331066-ediowz4s 312 26 , , , cord-331066-ediowz4s 312 27 Typically typically RB cord-331066-ediowz4s 312 28 , , , cord-331066-ediowz4s 312 29 the the DT cord-331066-ediowz4s 312 30 Boltzmann Boltzmann NNP cord-331066-ediowz4s 312 31 factor factor NN cord-331066-ediowz4s 312 32 grows grow VBZ cord-331066-ediowz4s 312 33 at at IN cord-331066-ediowz4s 312 34 the the DT cord-331066-ediowz4s 312 35 lower low JJR cord-331066-ediowz4s 312 36 temperatures temperature NNS cord-331066-ediowz4s 312 37 . . . cord-331066-ediowz4s 313 1 This this DT cord-331066-ediowz4s 313 2 means mean VBZ cord-331066-ediowz4s 313 3 that that IN cord-331066-ediowz4s 313 4 weakly weakly RB cord-331066-ediowz4s 313 5 specific specific JJ cord-331066-ediowz4s 313 6 effects effect NNS cord-331066-ediowz4s 313 7 should should MD cord-331066-ediowz4s 313 8 be be VB cord-331066-ediowz4s 313 9 more more RBR cord-331066-ediowz4s 313 10 pronounced pronounced JJ cord-331066-ediowz4s 313 11 at at IN cord-331066-ediowz4s 313 12 the the DT cord-331066-ediowz4s 313 13 lower low JJR cord-331066-ediowz4s 313 14 temperatures temperature NNS cord-331066-ediowz4s 313 15 . . . cord-331066-ediowz4s 314 1 Taking take VBG cord-331066-ediowz4s 314 2 into into IN cord-331066-ediowz4s 314 3 account account NN cord-331066-ediowz4s 314 4 huge huge JJ cord-331066-ediowz4s 314 5 numbers number NNS cord-331066-ediowz4s 314 6 of of IN cord-331066-ediowz4s 314 7 species specie NNS cord-331066-ediowz4s 314 8 in in IN cord-331066-ediowz4s 314 9 virus virus NN cord-331066-ediowz4s 314 10 populations population NNS cord-331066-ediowz4s 314 11 , , , cord-331066-ediowz4s 314 12 even even RB cord-331066-ediowz4s 314 13 a a DT cord-331066-ediowz4s 314 14 small small JJ cord-331066-ediowz4s 314 15 decrease decrease NN cord-331066-ediowz4s 314 16 in in IN cord-331066-ediowz4s 314 17 free free JJ cord-331066-ediowz4s 314 18 energy energy NN cord-331066-ediowz4s 314 19 may may MD cord-331066-ediowz4s 314 20 produce produce VB cord-331066-ediowz4s 314 21 a a DT cord-331066-ediowz4s 314 22 significant significant JJ cord-331066-ediowz4s 314 23 impact impact NN cord-331066-ediowz4s 314 24 and and CC cord-331066-ediowz4s 314 25 be be VB cord-331066-ediowz4s 314 26 advantageous advantageous JJ cord-331066-ediowz4s 314 27 for for IN cord-331066-ediowz4s 314 28 the the DT cord-331066-ediowz4s 314 29 natural natural JJ cord-331066-ediowz4s 314 30 selection selection NN cord-331066-ediowz4s 314 31 . . . cord-331066-ediowz4s 315 1 The the DT cord-331066-ediowz4s 315 2 methods method NNS cord-331066-ediowz4s 315 3 developed develop VBN cord-331066-ediowz4s 315 4 in in IN cord-331066-ediowz4s 315 5 this this DT cord-331066-ediowz4s 315 6 article article NN cord-331066-ediowz4s 315 7 are be VBP cord-331066-ediowz4s 315 8 quite quite RB cord-331066-ediowz4s 315 9 general general JJ cord-331066-ediowz4s 315 10 and and CC cord-331066-ediowz4s 315 11 can can MD cord-331066-ediowz4s 315 12 be be VB cord-331066-ediowz4s 315 13 applied apply VBN cord-331066-ediowz4s 315 14 to to IN cord-331066-ediowz4s 315 15 the the DT cord-331066-ediowz4s 315 16 detection detection NN cord-331066-ediowz4s 315 17 of of IN cord-331066-ediowz4s 315 18 assembly assembly NN cord-331066-ediowz4s 315 19 / / SYM cord-331066-ediowz4s 315 20 packaging packaging NN cord-331066-ediowz4s 315 21 signals signal NNS cord-331066-ediowz4s 315 22 in in IN cord-331066-ediowz4s 315 23 all all DT cord-331066-ediowz4s 315 24 viral viral JJ cord-331066-ediowz4s 315 25 genomes genome NNS cord-331066-ediowz4s 315 26 packaged package VBN cord-331066-ediowz4s 315 27 within within IN cord-331066-ediowz4s 315 28 helical helical JJ cord-331066-ediowz4s 315 29 capsids capsid NNS cord-331066-ediowz4s 315 30 including include VBG cord-331066-ediowz4s 315 31 the the DT cord-331066-ediowz4s 315 32 other other JJ cord-331066-ediowz4s 315 33 infectious infectious JJ cord-331066-ediowz4s 315 34 coronaviruses coronaviruse NNS cord-331066-ediowz4s 315 35 such such JJ cord-331066-ediowz4s 315 36 as as IN cord-331066-ediowz4s 315 37 229E 229e CD cord-331066-ediowz4s 315 38 , , , cord-331066-ediowz4s 315 39 NL63 NL63 NNP cord-331066-ediowz4s 315 40 , , , cord-331066-ediowz4s 315 41 OC43 OC43 NNP cord-331066-ediowz4s 315 42 , , , cord-331066-ediowz4s 315 43 HKU1 HKU1 NNP cord-331066-ediowz4s 315 44 and and CC cord-331066-ediowz4s 315 45 MERS MERS NNP cord-331066-ediowz4s 316 1 -CoV. -cov. ADD cord-331066-ediowz4s 317 1 The the DT cord-331066-ediowz4s 317 2 ssRNA ssRNA VBG cord-331066-ediowz4s 317 3 genomes genome NNS cord-331066-ediowz4s 317 4 of of IN cord-331066-ediowz4s 317 5 numerous numerous JJ cord-331066-ediowz4s 317 6 filamentous filamentous JJ cord-331066-ediowz4s 317 7 and and CC cord-331066-ediowz4s 317 8 rod rod NN cord-331066-ediowz4s 317 9 - - HYPH cord-331066-ediowz4s 317 10 shaped shape VBN cord-331066-ediowz4s 317 11 plant plant NN cord-331066-ediowz4s 317 12 viruses virus NNS cord-331066-ediowz4s 317 13 are be VBP cord-331066-ediowz4s 317 14 also also RB cord-331066-ediowz4s 317 15 packaged package VBN cord-331066-ediowz4s 317 16 within within IN cord-331066-ediowz4s 317 17 capsids capsid NNS cord-331066-ediowz4s 317 18 with with IN cord-331066-ediowz4s 317 19 helical helical JJ cord-331066-ediowz4s 317 20 symmetry symmetry NN cord-331066-ediowz4s 317 21 ( ( -LRB- cord-331066-ediowz4s 317 22 Solovyev Solovyev NNP cord-331066-ediowz4s 317 23 & & CC cord-331066-ediowz4s 317 24 Makarov Makarov NNP cord-331066-ediowz4s 317 25 , , , cord-331066-ediowz4s 317 26 2016 2016 CD cord-331066-ediowz4s 317 27 ; ; : cord-331066-ediowz4s 317 28 Stubbs Stubbs NNP cord-331066-ediowz4s 317 29 & & CC cord-331066-ediowz4s 317 30 Kendall Kendall NNP cord-331066-ediowz4s 317 31 , , , cord-331066-ediowz4s 317 32 2012 2012 CD cord-331066-ediowz4s 317 33 ) ) -RRB- cord-331066-ediowz4s 317 34 . . . cord-331066-ediowz4s 318 1 As as IN cord-331066-ediowz4s 318 2 shown show VBN cord-331066-ediowz4s 318 3 , , , cord-331066-ediowz4s 318 4 combining combine VBG cord-331066-ediowz4s 318 5 NCF NCF NNP cord-331066-ediowz4s 318 6 , , , cord-331066-ediowz4s 318 7 DFT DFT NNP cord-331066-ediowz4s 318 8 and and CC cord-331066-ediowz4s 318 9 DDFT DDFT NNP cord-331066-ediowz4s 318 10 provides provide VBZ cord-331066-ediowz4s 318 11 efficient efficient JJ cord-331066-ediowz4s 318 12 tools tool NNS cord-331066-ediowz4s 318 13 for for IN cord-331066-ediowz4s 318 14 the the DT cord-331066-ediowz4s 318 15 investigation investigation NN cord-331066-ediowz4s 318 16 of of IN cord-331066-ediowz4s 318 17 this this DT cord-331066-ediowz4s 318 18 problem problem NN cord-331066-ediowz4s 318 19 . . . cord-331066-ediowz4s 319 1 It -PRON- PRP cord-331066-ediowz4s 319 2 is be VBZ cord-331066-ediowz4s 319 3 essential essential JJ cord-331066-ediowz4s 319 4 that that IN cord-331066-ediowz4s 319 5 dominating dominate VBG cord-331066-ediowz4s 319 6 triplet triplet NN cord-331066-ediowz4s 319 7 periodicity periodicity NN cord-331066-ediowz4s 319 8 p p NN cord-331066-ediowz4s 319 9 ¼ ¼ NN cord-331066-ediowz4s 319 10 3 3 CD cord-331066-ediowz4s 319 11 typical typical NN cord-331066-ediowz4s 319 12 of of IN cord-331066-ediowz4s 319 13 protein protein NN cord-331066-ediowz4s 319 14 coding coding NN cord-331066-ediowz4s 319 15 regions region NNS cord-331066-ediowz4s 319 16 in in IN cord-331066-ediowz4s 319 17 the the DT cord-331066-ediowz4s 319 18 viral viral JJ cord-331066-ediowz4s 319 19 genomes genome NNS cord-331066-ediowz4s 319 20 should should MD cord-331066-ediowz4s 319 21 be be VB cord-331066-ediowz4s 319 22 suppressed suppress VBN cord-331066-ediowz4s 319 23 to to TO cord-331066-ediowz4s 319 24 discern discern VB cord-331066-ediowz4s 319 25 the the DT cord-331066-ediowz4s 319 26 longer long RBR cord-331066-ediowz4s 319 27 periodic periodic JJ cord-331066-ediowz4s 319 28 patterns pattern NNS cord-331066-ediowz4s 319 29 related relate VBN cord-331066-ediowz4s 319 30 to to IN cord-331066-ediowz4s 319 31 the the DT cord-331066-ediowz4s 319 32 assembly assembly NN cord-331066-ediowz4s 319 33 / / SYM cord-331066-ediowz4s 319 34 packaging packaging NN cord-331066-ediowz4s 319 35 signals signal NNS cord-331066-ediowz4s 319 36 . . . cord-331066-ediowz4s 320 1 After after IN cord-331066-ediowz4s 320 2 detection detection NN cord-331066-ediowz4s 320 3 of of IN cord-331066-ediowz4s 320 4 periodic periodic JJ cord-331066-ediowz4s 320 5 patterns pattern NNS cord-331066-ediowz4s 320 6 and and CC cord-331066-ediowz4s 320 7 determination determination NN cord-331066-ediowz4s 320 8 of of IN cord-331066-ediowz4s 320 9 their -PRON- PRP$ cord-331066-ediowz4s 320 10 periods period NNS cord-331066-ediowz4s 320 11 , , , cord-331066-ediowz4s 320 12 the the DT cord-331066-ediowz4s 320 13 underlying underlie VBG cord-331066-ediowz4s 320 14 motifs motif NNS cord-331066-ediowz4s 320 15 can can MD cord-331066-ediowz4s 320 16 be be VB cord-331066-ediowz4s 320 17 explicitly explicitly RB cord-331066-ediowz4s 320 18 reconstructed reconstruct VBN cord-331066-ediowz4s 320 19 by by IN cord-331066-ediowz4s 320 20 TAMGI TAMGI NNP cord-331066-ediowz4s 320 21 . . . cord-331066-ediowz4s 321 1 Generally generally RB cord-331066-ediowz4s 321 2 , , , cord-331066-ediowz4s 321 3 TAMGI TAMGI NNP cord-331066-ediowz4s 321 4 can can MD cord-331066-ediowz4s 321 5 be be VB cord-331066-ediowz4s 321 6 efficiently efficiently RB cord-331066-ediowz4s 321 7 used use VBN cord-331066-ediowz4s 321 8 for for IN cord-331066-ediowz4s 321 9 data datum NNS cord-331066-ediowz4s 321 10 mining mining NN cord-331066-ediowz4s 321 11 and and CC cord-331066-ediowz4s 321 12 search search NN cord-331066-ediowz4s 321 13 for for IN cord-331066-ediowz4s 321 14 cis cis NNP cord-331066-ediowz4s 321 15 / / SYM cord-331066-ediowz4s 321 16 trans trans NNP cord-331066-ediowz4s 321 17 - - NNS cord-331066-ediowz4s 321 18 elements element NNS cord-331066-ediowz4s 321 19 in in IN cord-331066-ediowz4s 321 20 genomic genomic JJ cord-331066-ediowz4s 321 21 sequences sequence NNS cord-331066-ediowz4s 321 22 . . . cord-331066-ediowz4s 322 1 The the DT cord-331066-ediowz4s 322 2 mutual mutual JJ cord-331066-ediowz4s 322 3 experimental experimental JJ cord-331066-ediowz4s 322 4 and and CC cord-331066-ediowz4s 322 5 bioinformatic bioinformatic JJ cord-331066-ediowz4s 322 6 analysis analysis NN cord-331066-ediowz4s 322 7 and and CC cord-331066-ediowz4s 322 8 the the DT cord-331066-ediowz4s 322 9 knowledge knowledge NN cord-331066-ediowz4s 322 10 about about IN cord-331066-ediowz4s 322 11 the the DT cord-331066-ediowz4s 322 12 assembly assembly NN cord-331066-ediowz4s 322 13 / / SYM cord-331066-ediowz4s 322 14 packaging packaging NN cord-331066-ediowz4s 322 15 mechanisms mechanism NNS cord-331066-ediowz4s 322 16 in in IN cord-331066-ediowz4s 322 17 viral viral JJ cord-331066-ediowz4s 322 18 genomes genome NNS cord-331066-ediowz4s 322 19 should should MD cord-331066-ediowz4s 322 20 facilitate facilitate VB cord-331066-ediowz4s 322 21 the the DT cord-331066-ediowz4s 322 22 choice choice NN cord-331066-ediowz4s 322 23 of of IN cord-331066-ediowz4s 322 24 the the DT cord-331066-ediowz4s 322 25 most most RBS cord-331066-ediowz4s 322 26 efficient efficient JJ cord-331066-ediowz4s 322 27 strategy strategy NN cord-331066-ediowz4s 322 28 in in IN cord-331066-ediowz4s 322 29 practical practical JJ cord-331066-ediowz4s 322 30 medical medical JJ cord-331066-ediowz4s 322 31 applications application NNS cord-331066-ediowz4s 322 32 . . . cord-331066-ediowz4s 323 1 The the DT cord-331066-ediowz4s 323 2 regular regular JJ cord-331066-ediowz4s 323 3 study study NN cord-331066-ediowz4s 323 4 of of IN cord-331066-ediowz4s 323 5 hidden hidden JJ cord-331066-ediowz4s 323 6 quasi quasi JJ cord-331066-ediowz4s 323 7 - - JJ cord-331066-ediowz4s 323 8 periodic periodic JJ cord-331066-ediowz4s 323 9 patterns pattern NNS cord-331066-ediowz4s 323 10 is be VBZ cord-331066-ediowz4s 323 11 of of IN cord-331066-ediowz4s 323 12 basic basic JJ cord-331066-ediowz4s 323 13 interest interest NN cord-331066-ediowz4s 323 14 for for IN cord-331066-ediowz4s 323 15 the the DT cord-331066-ediowz4s 323 16 virology virology NN cord-331066-ediowz4s 323 17 . . . cord-331066-ediowz4s 324 1 No no DT cord-331066-ediowz4s 324 2 potential potential JJ cord-331066-ediowz4s 324 3 conflict conflict NN cord-331066-ediowz4s 324 4 of of IN cord-331066-ediowz4s 324 5 interest interest NN cord-331066-ediowz4s 324 6 was be VBD cord-331066-ediowz4s 324 7 reported report VBN cord-331066-ediowz4s 324 8 by by IN cord-331066-ediowz4s 324 9 the the DT cord-331066-ediowz4s 324 10 authors author NNS cord-331066-ediowz4s 324 11 . . . cord-331066-ediowz4s 325 1 The the DT cord-331066-ediowz4s 325 2 proximal proximal JJ cord-331066-ediowz4s 325 3 origin origin NN cord-331066-ediowz4s 325 4 of of IN cord-331066-ediowz4s 325 5 SARS SARS NNP cord-331066-ediowz4s 325 6 - - HYPH cord-331066-ediowz4s 325 7 CoV-2 CoV-2 NNP cord-331066-ediowz4s 325 8 Practical practical JJ cord-331066-ediowz4s 325 9 applications application NNS cord-331066-ediowz4s 325 10 of of IN cord-331066-ediowz4s 325 11 DNA dna NN cord-331066-ediowz4s 325 12 genotyping genotyping NN cord-331066-ediowz4s 325 13 in in IN cord-331066-ediowz4s 325 14 diagnostic diagnostic JJ cord-331066-ediowz4s 325 15 pathology pathology NN cord-331066-ediowz4s 325 16 DNA dna NN cord-331066-ediowz4s 325 17 polymorphism polymorphism NN cord-331066-ediowz4s 325 18 in in IN cord-331066-ediowz4s 325 19 the the DT cord-331066-ediowz4s 325 20 b b NN cord-331066-ediowz4s 325 21 - - HYPH cord-331066-ediowz4s 325 22 esterase esterase NN cord-331066-ediowz4s 325 23 gene gene NN cord-331066-ediowz4s 325 24 cluster cluster NN cord-331066-ediowz4s 325 25 of of IN cord-331066-ediowz4s 325 26 Drosophila Drosophila NNP cord-331066-ediowz4s 325 27 melanogaster melanogaster NN cord-331066-ediowz4s 325 28 Entropy Entropy NNP cord-331066-ediowz4s 325 29 and and CC cord-331066-ediowz4s 325 30 GC GC NNP cord-331066-ediowz4s 325 31 content content NN cord-331066-ediowz4s 325 32 in in IN cord-331066-ediowz4s 325 33 the the DT cord-331066-ediowz4s 325 34 beta beta JJ cord-331066-ediowz4s 325 35 - - HYPH cord-331066-ediowz4s 325 36 esterase esterase NN cord-331066-ediowz4s 325 37 gene gene NN cord-331066-ediowz4s 325 38 cluster cluster NN cord-331066-ediowz4s 325 39 of of IN cord-331066-ediowz4s 325 40 the the DT cord-331066-ediowz4s 325 41 Drosophila Drosophila NNP cord-331066-ediowz4s 325 42 melanogaster melanogaster NN cord-331066-ediowz4s 325 43 subgroup subgroup NN cord-331066-ediowz4s 325 44 Computational computational JJ cord-331066-ediowz4s 325 45 methods method NNS cord-331066-ediowz4s 325 46 of of IN cord-331066-ediowz4s 325 47 identification identification NN cord-331066-ediowz4s 325 48 of of IN cord-331066-ediowz4s 325 49 pseudogenes pseudogene NNS cord-331066-ediowz4s 325 50 based base VBN cord-331066-ediowz4s 325 51 on on IN cord-331066-ediowz4s 325 52 functionality functionality NN cord-331066-ediowz4s 325 53 : : : cord-331066-ediowz4s 325 54 Entropy Entropy NNP cord-331066-ediowz4s 325 55 and and CC cord-331066-ediowz4s 325 56 GC GC NNP cord-331066-ediowz4s 325 57 content content NN cord-331066-ediowz4s 325 58 Short Short NNP cord-331066-ediowz4s 325 59 fuzzy fuzzy JJ cord-331066-ediowz4s 325 60 tandem tandem NN cord-331066-ediowz4s 325 61 repeats repeat VBZ cord-331066-ediowz4s 325 62 in in IN cord-331066-ediowz4s 325 63 genomic genomic JJ cord-331066-ediowz4s 325 64 sequences sequence NNS cord-331066-ediowz4s 325 65 , , , cord-331066-ediowz4s 325 66 identification identification NN cord-331066-ediowz4s 325 67 , , , cord-331066-ediowz4s 325 68 and and CC cord-331066-ediowz4s 325 69 possible possible JJ cord-331066-ediowz4s 325 70 role role NN cord-331066-ediowz4s 325 71 in in IN cord-331066-ediowz4s 325 72 regulation regulation NN cord-331066-ediowz4s 325 73 of of IN cord-331066-ediowz4s 325 74 gene gene NN cord-331066-ediowz4s 325 75 expression expression NN cord-331066-ediowz4s 325 76 Advanced advanced JJ cord-331066-ediowz4s 325 77 topics topic NNS cord-331066-ediowz4s 325 78 in in IN cord-331066-ediowz4s 325 79 forensic forensic JJ cord-331066-ediowz4s 325 80 DNA dna NN cord-331066-ediowz4s 325 81 typing typing NN cord-331066-ediowz4s 325 82 : : : cord-331066-ediowz4s 326 1 Methodology methodology NN cord-331066-ediowz4s 326 2 Computational computational JJ cord-331066-ediowz4s 326 3 inference inference NN cord-331066-ediowz4s 326 4 of of IN cord-331066-ediowz4s 326 5 selection selection NN cord-331066-ediowz4s 326 6 underlying underlie VBG cord-331066-ediowz4s 326 7 the the DT cord-331066-ediowz4s 326 8 evolution evolution NN cord-331066-ediowz4s 326 9 of of IN cord-331066-ediowz4s 326 10 the the DT cord-331066-ediowz4s 326 11 novel novel JJ cord-331066-ediowz4s 326 12 coronavirus coronavirus NN cord-331066-ediowz4s 326 13 , , , cord-331066-ediowz4s 326 14 severe severe JJ cord-331066-ediowz4s 326 15 acute acute JJ cord-331066-ediowz4s 326 16 respiratory respiratory JJ cord-331066-ediowz4s 326 17 syndrome syndrome NN cord-331066-ediowz4s 326 18 coronavirus coronavirus NN cord-331066-ediowz4s 326 19 2 2 CD cord-331066-ediowz4s 327 1 The the DT cord-331066-ediowz4s 327 2 SARS SARS NNP cord-331066-ediowz4s 327 3 coronavirus coronavirus NN cord-331066-ediowz4s 327 4 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 327 5 protein protein NN cord-331066-ediowz4s 327 6 - - HYPH cord-331066-ediowz4s 327 7 forms form NNS cord-331066-ediowz4s 327 8 and and CC cord-331066-ediowz4s 327 9 functions function VBZ cord-331066-ediowz4s 327 10 Multiple multiple JJ cord-331066-ediowz4s 327 11 nucleic nucleic JJ cord-331066-ediowz4s 327 12 acid acid NN cord-331066-ediowz4s 327 13 binding bind VBG cord-331066-ediowz4s 327 14 sites site NNS cord-331066-ediowz4s 327 15 and and CC cord-331066-ediowz4s 327 16 intrinsic intrinsic JJ cord-331066-ediowz4s 327 17 disorder disorder NN cord-331066-ediowz4s 327 18 of of IN cord-331066-ediowz4s 327 19 severe severe JJ cord-331066-ediowz4s 327 20 acute acute JJ cord-331066-ediowz4s 327 21 respiratory respiratory JJ cord-331066-ediowz4s 327 22 syndrome syndrome NN cord-331066-ediowz4s 327 23 coronavirus coronavirus NN cord-331066-ediowz4s 327 24 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 327 25 protein protein NN cord-331066-ediowz4s 327 26 : : : cord-331066-ediowz4s 327 27 Implications implication NNS cord-331066-ediowz4s 327 28 for for IN cord-331066-ediowz4s 327 29 ribonucleocapsid ribonucleocapsid NNP cord-331066-ediowz4s 327 30 protein protein NNP cord-331066-ediowz4s 328 1 packaging package VBG cord-331066-ediowz4s 328 2 Recent recent JJ cord-331066-ediowz4s 328 3 insights insight NNS cord-331066-ediowz4s 328 4 into into IN cord-331066-ediowz4s 328 5 the the DT cord-331066-ediowz4s 328 6 development development NN cord-331066-ediowz4s 328 7 of of IN cord-331066-ediowz4s 328 8 therapeutics therapeutic NNS cord-331066-ediowz4s 328 9 against against IN cord-331066-ediowz4s 328 10 coronavirus coronavirus NN cord-331066-ediowz4s 328 11 diseases disease NNS cord-331066-ediowz4s 328 12 by by IN cord-331066-ediowz4s 328 13 targeting target VBG cord-331066-ediowz4s 328 14 N n CD cord-331066-ediowz4s 328 15 protein protein NN cord-331066-ediowz4s 328 16 Spectral spectral JJ cord-331066-ediowz4s 328 17 sum sum NN cord-331066-ediowz4s 328 18 rules rule NNS cord-331066-ediowz4s 328 19 and and CC cord-331066-ediowz4s 328 20 search search VB cord-331066-ediowz4s 328 21 for for IN cord-331066-ediowz4s 328 22 periodicities periodicity NNS cord-331066-ediowz4s 328 23 in in IN cord-331066-ediowz4s 328 24 DNA dna NN cord-331066-ediowz4s 328 25 sequences sequence NNS cord-331066-ediowz4s 328 26 Levels level NNS cord-331066-ediowz4s 328 27 of of IN cord-331066-ediowz4s 328 28 ordering order VBG cord-331066-ediowz4s 328 29 in in IN cord-331066-ediowz4s 328 30 coding code VBG cord-331066-ediowz4s 328 31 and and CC cord-331066-ediowz4s 328 32 non non JJ cord-331066-ediowz4s 328 33 - - JJ cord-331066-ediowz4s 328 34 coding coding JJ cord-331066-ediowz4s 328 35 regions region NNS cord-331066-ediowz4s 328 36 of of IN cord-331066-ediowz4s 328 37 DNA dna NN cord-331066-ediowz4s 328 38 sequences sequence NNS cord-331066-ediowz4s 328 39 Large large JJ cord-331066-ediowz4s 328 40 - - HYPH cord-331066-ediowz4s 328 41 scale scale NN cord-331066-ediowz4s 328 42 chromosome chromosome NN cord-331066-ediowz4s 328 43 folding fold VBG cord-331066-ediowz4s 328 44 versus versus IN cord-331066-ediowz4s 328 45 genomic genomic JJ cord-331066-ediowz4s 328 46 DNA dna NN cord-331066-ediowz4s 328 47 sequences sequence NNS cord-331066-ediowz4s 328 48 : : : cord-331066-ediowz4s 329 1 A a DT cord-331066-ediowz4s 329 2 discrete discrete JJ cord-331066-ediowz4s 329 3 double double JJ cord-331066-ediowz4s 329 4 Fourier Fourier NNP cord-331066-ediowz4s 329 5 transform transform NN cord-331066-ediowz4s 329 6 technique technique NN cord-331066-ediowz4s 329 7 Genome genome NN cord-331066-ediowz4s 329 8 packaging packaging NN cord-331066-ediowz4s 329 9 within within IN cord-331066-ediowz4s 329 10 icosahedral icosahedral JJ cord-331066-ediowz4s 329 11 capsids capsid NNS cord-331066-ediowz4s 329 12 and and CC cord-331066-ediowz4s 329 13 large large JJ cord-331066-ediowz4s 329 14 - - HYPH cord-331066-ediowz4s 329 15 scale scale NN cord-331066-ediowz4s 329 16 segmentation segmentation NN cord-331066-ediowz4s 329 17 in in IN cord-331066-ediowz4s 329 18 viral viral JJ cord-331066-ediowz4s 329 19 genomic genomic JJ cord-331066-ediowz4s 329 20 sequences sequence NNS cord-331066-ediowz4s 329 21 Detection Detection NNP cord-331066-ediowz4s 329 22 of of IN cord-331066-ediowz4s 329 23 large large JJ cord-331066-ediowz4s 329 24 - - HYPH cord-331066-ediowz4s 329 25 scale scale NN cord-331066-ediowz4s 329 26 noisy noisy JJ cord-331066-ediowz4s 329 27 multi multi JJ cord-331066-ediowz4s 329 28 - - JJ cord-331066-ediowz4s 329 29 periodic periodic JJ cord-331066-ediowz4s 329 30 patterns pattern NNS cord-331066-ediowz4s 329 31 with with IN cord-331066-ediowz4s 329 32 discrete discrete JJ cord-331066-ediowz4s 329 33 double double JJ cord-331066-ediowz4s 329 34 Fourier Fourier NNP cord-331066-ediowz4s 329 35 transform transform NN cord-331066-ediowz4s 329 36 . . . cord-331066-ediowz4s 330 1 Fluctuation fluctuation NN cord-331066-ediowz4s 330 2 and and CC cord-331066-ediowz4s 330 3 Noise Noise NNP cord-331066-ediowz4s 330 4 Letters Letters NNP cord-331066-ediowz4s 330 5 Detection Detection NNP cord-331066-ediowz4s 330 6 of of IN cord-331066-ediowz4s 330 7 large large JJ cord-331066-ediowz4s 330 8 - - HYPH cord-331066-ediowz4s 330 9 scale scale NN cord-331066-ediowz4s 330 10 noisy noisy JJ cord-331066-ediowz4s 330 11 multi multi JJ cord-331066-ediowz4s 330 12 - - JJ cord-331066-ediowz4s 330 13 periodic periodic JJ cord-331066-ediowz4s 330 14 patterns pattern NNS cord-331066-ediowz4s 330 15 with with IN cord-331066-ediowz4s 330 16 discrete discrete JJ cord-331066-ediowz4s 330 17 double double JJ cord-331066-ediowz4s 330 18 Fourier Fourier NNP cord-331066-ediowz4s 330 19 transform transform NN cord-331066-ediowz4s 330 20 . . . cord-331066-ediowz4s 331 1 II II NNP cord-331066-ediowz4s 331 2 . . . cord-331066-ediowz4s 332 1 Study study NN cord-331066-ediowz4s 332 2 of of IN cord-331066-ediowz4s 332 3 correlations correlation NNS cord-331066-ediowz4s 332 4 between between IN cord-331066-ediowz4s 332 5 patterns pattern NNS cord-331066-ediowz4s 332 6 . . . cord-331066-ediowz4s 333 1 Fluctuation fluctuation NN cord-331066-ediowz4s 333 2 and and CC cord-331066-ediowz4s 333 3 Noise noise NN cord-331066-ediowz4s 333 4 Letters letter NNS cord-331066-ediowz4s 334 1 On on IN cord-331066-ediowz4s 334 2 the the DT cord-331066-ediowz4s 334 3 spectral spectral JJ cord-331066-ediowz4s 334 4 criteria criterion NNS cord-331066-ediowz4s 334 5 of of IN cord-331066-ediowz4s 334 6 disorder disorder NN cord-331066-ediowz4s 334 7 in in IN cord-331066-ediowz4s 334 8 non non JJ cord-331066-ediowz4s 334 9 - - JJ cord-331066-ediowz4s 334 10 periodic periodic JJ cord-331066-ediowz4s 334 11 sequences sequence NNS cord-331066-ediowz4s 334 12 : : : cord-331066-ediowz4s 334 13 Application application NN cord-331066-ediowz4s 334 14 to to IN cord-331066-ediowz4s 334 15 inflation inflation NN cord-331066-ediowz4s 334 16 models model NNS cord-331066-ediowz4s 334 17 , , , cord-331066-ediowz4s 334 18 symbolic symbolic JJ cord-331066-ediowz4s 334 19 dynamics dynamic NNS cord-331066-ediowz4s 334 20 and and CC cord-331066-ediowz4s 334 21 DNA dna NN cord-331066-ediowz4s 334 22 sequences sequence NNS cord-331066-ediowz4s 334 23 Search search NN cord-331066-ediowz4s 334 24 of of IN cord-331066-ediowz4s 334 25 hidden hidden JJ cord-331066-ediowz4s 334 26 periodicities periodicity NNS cord-331066-ediowz4s 334 27 in in IN cord-331066-ediowz4s 334 28 DNA dna NN cord-331066-ediowz4s 334 29 sequences sequence NNS cord-331066-ediowz4s 334 30 Structure Structure NNP cord-331066-ediowz4s 334 31 of of IN cord-331066-ediowz4s 334 32 the the DT cord-331066-ediowz4s 334 33 SARS SARS NNP cord-331066-ediowz4s 334 34 coronavirus coronavirus NN cord-331066-ediowz4s 334 35 nucleocapsid nucleocapsid NNP cord-331066-ediowz4s 334 36 protein protein NN cord-331066-ediowz4s 334 37 RNA RNA NNP cord-331066-ediowz4s 334 38 - - HYPH cord-331066-ediowz4s 334 39 binding bind VBG cord-331066-ediowz4s 334 40 dimerization dimerization NN cord-331066-ediowz4s 334 41 domain domain NN cord-331066-ediowz4s 334 42 suggests suggest VBZ cord-331066-ediowz4s 334 43 a a DT cord-331066-ediowz4s 334 44 mechanism mechanism NN cord-331066-ediowz4s 334 45 for for IN cord-331066-ediowz4s 334 46 helical helical JJ cord-331066-ediowz4s 334 47 packaging packaging NN cord-331066-ediowz4s 334 48 of of IN cord-331066-ediowz4s 334 49 viral viral JJ cord-331066-ediowz4s 334 50 RNA RNA NNP cord-331066-ediowz4s 334 51 DNA dna NN cord-331066-ediowz4s 334 52 microarrays microarray NNS cord-331066-ediowz4s 334 53 for for IN cord-331066-ediowz4s 334 54 biomedical biomedical JJ cord-331066-ediowz4s 334 55 research research NN cord-331066-ediowz4s 334 56 : : : cord-331066-ediowz4s 334 57 Methods method NNS cord-331066-ediowz4s 334 58 and and CC cord-331066-ediowz4s 334 59 protocols protocol NNS cord-331066-ediowz4s 334 60 Severe severe JJ cord-331066-ediowz4s 334 61 acute acute JJ cord-331066-ediowz4s 334 62 respiratory respiratory JJ cord-331066-ediowz4s 334 63 syndrome syndrome NN cord-331066-ediowz4s 334 64 coronavirus coronavirus NN cord-331066-ediowz4s 334 65 2 2 CD cord-331066-ediowz4s 335 1 ( ( -LRB- cord-331066-ediowz4s 335 2 SARS SARS NNP cord-331066-ediowz4s 335 3 - - HYPH cord-331066-ediowz4s 335 4 CoV-2 CoV-2 NNP cord-331066-ediowz4s 335 5 ) ) -RRB- cord-331066-ediowz4s 335 6 : : : cord-331066-ediowz4s 336 1 A a DT cord-331066-ediowz4s 336 2 review review NN cord-331066-ediowz4s 336 3 Modular modular JJ cord-331066-ediowz4s 336 4 recognition recognition NN cord-331066-ediowz4s 336 5 of of IN cord-331066-ediowz4s 336 6 nucleic nucleic JJ cord-331066-ediowz4s 336 7 acids acid NNS cord-331066-ediowz4s 336 8 by by IN cord-331066-ediowz4s 336 9 PUF PUF NNP cord-331066-ediowz4s 336 10 , , , cord-331066-ediowz4s 337 1 TALE tale NN cord-331066-ediowz4s 337 2 and and CC cord-331066-ediowz4s 337 3 PPR ppr NN cord-331066-ediowz4s 337 4 proteins protein NNS cord-331066-ediowz4s 337 5 Phylogenetic Phylogenetic NNP cord-331066-ediowz4s 337 6 network network NN cord-331066-ediowz4s 337 7 analysis analysis NN cord-331066-ediowz4s 337 8 of of IN cord-331066-ediowz4s 337 9 SARS SARS NNP cord-331066-ediowz4s 337 10 - - HYPH cord-331066-ediowz4s 337 11 CoV-2 CoV-2 NNP cord-331066-ediowz4s 337 12 genomes genome NNS cord-331066-ediowz4s 337 13 Identification identification NN cord-331066-ediowz4s 337 14 and and CC cord-331066-ediowz4s 337 15 characterization characterization NN cord-331066-ediowz4s 337 16 of of IN cord-331066-ediowz4s 337 17 a a DT cord-331066-ediowz4s 337 18 coronavirus coronavirus NN cord-331066-ediowz4s 337 19 packaging packaging NN cord-331066-ediowz4s 337 20 signal signal NN cord-331066-ediowz4s 337 21 Human human JJ cord-331066-ediowz4s 337 22 coronavirus coronavirus NN cord-331066-ediowz4s 337 23 : : : cord-331066-ediowz4s 337 24 Host host NN cord-331066-ediowz4s 337 25 - - HYPH cord-331066-ediowz4s 337 26 pathogen pathogen NN cord-331066-ediowz4s 337 27 interaction interaction NN cord-331066-ediowz4s 337 28 Development development NN cord-331066-ediowz4s 337 29 and and CC cord-331066-ediowz4s 337 30 use use NN cord-331066-ediowz4s 337 31 of of IN cord-331066-ediowz4s 337 32 molecular molecular JJ cord-331066-ediowz4s 337 33 markers marker NNS cord-331066-ediowz4s 338 1 : : : cord-331066-ediowz4s 338 2 Past past NN cord-331066-ediowz4s 338 3 and and CC cord-331066-ediowz4s 338 4 present present JJ cord-331066-ediowz4s 338 5 Electron electron NN cord-331066-ediowz4s 338 6 microscopy microscopy NN cord-331066-ediowz4s 338 7 studies study NNS cord-331066-ediowz4s 338 8 of of IN cord-331066-ediowz4s 338 9 the the DT cord-331066-ediowz4s 338 10 coronavirus coronavirus NN cord-331066-ediowz4s 338 11 ribonucleoprotein ribonucleoprotein NN cord-331066-ediowz4s 338 12 complex complex JJ cord-331066-ediowz4s 338 13 De de NN cord-331066-ediowz4s 338 14 - - HYPH cord-331066-ediowz4s 338 15 coding code VBG cord-331066-ediowz4s 338 16 and and CC cord-331066-ediowz4s 338 17 re re NN cord-331066-ediowz4s 338 18 - - NN cord-331066-ediowz4s 338 19 coding code VBG cord-331066-ediowz4s 338 20 RNA rna NN cord-331066-ediowz4s 338 21 recognition recognition NN cord-331066-ediowz4s 338 22 by by IN cord-331066-ediowz4s 338 23 PUF PUF NNP cord-331066-ediowz4s 338 24 and and CC cord-331066-ediowz4s 338 25 PPR PPR NNP cord-331066-ediowz4s 338 26 repeat repeat NN cord-331066-ediowz4s 338 27 proteins protein NNS cord-331066-ediowz4s 339 1 An an DT cord-331066-ediowz4s 339 2 interaction interaction NN cord-331066-ediowz4s 339 3 between between IN cord-331066-ediowz4s 339 4 the the DT cord-331066-ediowz4s 339 5 nucleocapsid nucleocapsid NNP cord-331066-ediowz4s 339 6 protein protein NN cord-331066-ediowz4s 339 7 and and CC cord-331066-ediowz4s 339 8 a a DT cord-331066-ediowz4s 339 9 component component NN cord-331066-ediowz4s 339 10 of of IN cord-331066-ediowz4s 339 11 the the DT cord-331066-ediowz4s 339 12 replicase replicase NN cord-331066-ediowz4s 339 13 - - HYPH cord-331066-ediowz4s 339 14 transcriptase transcriptase NN cord-331066-ediowz4s 339 15 complex complex NN cord-331066-ediowz4s 339 16 is be VBZ cord-331066-ediowz4s 339 17 crucial crucial JJ cord-331066-ediowz4s 339 18 for for IN cord-331066-ediowz4s 339 19 the the DT cord-331066-ediowz4s 339 20 infectivity infectivity NN cord-331066-ediowz4s 339 21 of of IN cord-331066-ediowz4s 339 22 coronavirus coronavirus NN cord-331066-ediowz4s 339 23 genomic genomic JJ cord-331066-ediowz4s 339 24 RNA RNA NNP cord-331066-ediowz4s 339 25 Methods Methods NNPS cord-331066-ediowz4s 339 26 for for IN cord-331066-ediowz4s 339 27 assessing assess VBG cord-331066-ediowz4s 339 28 the the DT cord-331066-ediowz4s 339 29 statistical statistical JJ cord-331066-ediowz4s 339 30 significance significance NN cord-331066-ediowz4s 339 31 of of IN cord-331066-ediowz4s 339 32 molecular molecular JJ cord-331066-ediowz4s 339 33 sequence sequence NN cord-331066-ediowz4s 339 34 features feature NNS cord-331066-ediowz4s 339 35 by by IN cord-331066-ediowz4s 339 36 using use VBG cord-331066-ediowz4s 339 37 general general JJ cord-331066-ediowz4s 339 38 scoring scoring NN cord-331066-ediowz4s 339 39 schemes scheme NNS cord-331066-ediowz4s 339 40 Forensic forensic JJ cord-331066-ediowz4s 339 41 use use NN cord-331066-ediowz4s 339 42 of of IN cord-331066-ediowz4s 339 43 Y y NN cord-331066-ediowz4s 339 44 - - HYPH cord-331066-ediowz4s 339 45 chromosome chromosome NN cord-331066-ediowz4s 339 46 DNA dna NN cord-331066-ediowz4s 339 47 : : : cord-331066-ediowz4s 340 1 A a DT cord-331066-ediowz4s 340 2 general general JJ cord-331066-ediowz4s 340 3 overview overview NN cord-331066-ediowz4s 340 4 RNA RNA NNP cord-331066-ediowz4s 340 5 vaccines vaccine NNS cord-331066-ediowz4s 340 6 Analyses analysis NNS cord-331066-ediowz4s 340 7 of of IN cord-331066-ediowz4s 340 8 coronavirus coronavirus NN cord-331066-ediowz4s 340 9 assembly assembly NN cord-331066-ediowz4s 340 10 interactions interaction NNS cord-331066-ediowz4s 340 11 with with IN cord-331066-ediowz4s 340 12 interspecies interspecie NNS cord-331066-ediowz4s 340 13 membrane membrane NN cord-331066-ediowz4s 340 14 and and CC cord-331066-ediowz4s 340 15 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 340 16 protein protein NN cord-331066-ediowz4s 340 17 chimeras chimeras NNP cord-331066-ediowz4s 340 18 Structure Structure NNP cord-331066-ediowz4s 340 19 - - HYPH cord-331066-ediowz4s 340 20 based base VBN cord-331066-ediowz4s 340 21 stabilization stabilization NN cord-331066-ediowz4s 340 22 of of IN cord-331066-ediowz4s 340 23 non non JJ cord-331066-ediowz4s 340 24 - - JJ cord-331066-ediowz4s 340 25 native native JJ cord-331066-ediowz4s 340 26 protein protein NN cord-331066-ediowz4s 340 27 - - HYPH cord-331066-ediowz4s 340 28 protein protein NN cord-331066-ediowz4s 340 29 interactions interaction NNS cord-331066-ediowz4s 340 30 of of IN cord-331066-ediowz4s 340 31 coronavirus coronavirus NN cord-331066-ediowz4s 340 32 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 340 33 proteins protein NNS cord-331066-ediowz4s 340 34 in in IN cord-331066-ediowz4s 340 35 antiviral antiviral JJ cord-331066-ediowz4s 340 36 drug drug NN cord-331066-ediowz4s 340 37 design design NN cord-331066-ediowz4s 340 38 Order order NN cord-331066-ediowz4s 340 39 and and CC cord-331066-ediowz4s 340 40 correlations correlation NNS cord-331066-ediowz4s 340 41 in in IN cord-331066-ediowz4s 340 42 genomic genomic JJ cord-331066-ediowz4s 340 43 DNA dna NN cord-331066-ediowz4s 340 44 sequences sequence NNS cord-331066-ediowz4s 340 45 . . . cord-331066-ediowz4s 341 1 The the DT cord-331066-ediowz4s 341 2 spectral spectral JJ cord-331066-ediowz4s 341 3 approach approach NN cord-331066-ediowz4s 341 4 RNA rna NN cord-331066-ediowz4s 341 5 - - HYPH cord-331066-ediowz4s 341 6 binding bind VBG cord-331066-ediowz4s 341 7 proteins protein NNS cord-331066-ediowz4s 341 8 : : : cord-331066-ediowz4s 342 1 Modular modular JJ cord-331066-ediowz4s 342 2 design design NN cord-331066-ediowz4s 342 3 for for IN cord-331066-ediowz4s 342 4 efficient efficient JJ cord-331066-ediowz4s 342 5 function function NN cord-331066-ediowz4s 343 1 No no DT cord-331066-ediowz4s 343 2 evidence evidence NN cord-331066-ediowz4s 343 3 for for IN cord-331066-ediowz4s 343 4 distinct distinct JJ cord-331066-ediowz4s 343 5 types type NNS cord-331066-ediowz4s 343 6 in in IN cord-331066-ediowz4s 343 7 the the DT cord-331066-ediowz4s 343 8 evolution evolution NN cord-331066-ediowz4s 343 9 of of IN cord-331066-ediowz4s 343 10 SARS SARS NNP cord-331066-ediowz4s 343 11 - - HYPH cord-331066-ediowz4s 343 12 CoV-2 CoV-2 NNP cord-331066-ediowz4s 343 13 Ribonucleoprotein Ribonucleoprotein NNP cord-331066-ediowz4s 343 14 - - HYPH cord-331066-ediowz4s 343 15 like like JJ cord-331066-ediowz4s 343 16 structures structure NNS cord-331066-ediowz4s 343 17 from from IN cord-331066-ediowz4s 343 18 coronavirus coronavirus NN cord-331066-ediowz4s 343 19 particles particle NNS cord-331066-ediowz4s 343 20 Coronavirus Coronavirus NNP cord-331066-ediowz4s 343 21 cisacting cisacte VBG cord-331066-ediowz4s 343 22 RNA RNA NNP cord-331066-ediowz4s 343 23 elements element NNS cord-331066-ediowz4s 343 24 Coronaviruses Coronaviruses NNP cord-331066-ediowz4s 343 25 . . . cord-331066-ediowz4s 344 1 In in IN cord-331066-ediowz4s 344 2 Methods method NNS cord-331066-ediowz4s 344 3 and and CC cord-331066-ediowz4s 344 4 protocols protocol NNS cord-331066-ediowz4s 344 5 Gene Gene NNP cord-331066-ediowz4s 344 6 prediction prediction NN cord-331066-ediowz4s 344 7 based base VBN cord-331066-ediowz4s 344 8 on on IN cord-331066-ediowz4s 344 9 DNA dna NN cord-331066-ediowz4s 344 10 spectral spectral JJ cord-331066-ediowz4s 344 11 analysis analysis NN cord-331066-ediowz4s 344 12 : : : cord-331066-ediowz4s 344 13 A a DT cord-331066-ediowz4s 344 14 literature literature NN cord-331066-ediowz4s 344 15 review review NN cord-331066-ediowz4s 344 16 Digital Digital NNP cord-331066-ediowz4s 344 17 spectral spectral JJ cord-331066-ediowz4s 344 18 analysis analysis NN cord-331066-ediowz4s 344 19 with with IN cord-331066-ediowz4s 344 20 applications application NNS cord-331066-ediowz4s 344 21 Coronavirus Coronavirus NNP cord-331066-ediowz4s 344 22 genomic genomic JJ cord-331066-ediowz4s 344 23 RNA rna NN cord-331066-ediowz4s 344 24 packaging packaging NN cord-331066-ediowz4s 345 1 The the DT cord-331066-ediowz4s 345 2 coronavirus coronavirus NN cord-331066-ediowz4s 345 3 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 345 4 is be VBZ cord-331066-ediowz4s 345 5 a a DT cord-331066-ediowz4s 345 6 multifunctional multifunctional JJ cord-331066-ediowz4s 345 7 protein protein NN cord-331066-ediowz4s 345 8 RNA RNA NNP cord-331066-ediowz4s 345 9 interference interference NN cord-331066-ediowz4s 345 10 Cooperation Cooperation NNP cord-331066-ediowz4s 345 11 of of IN cord-331066-ediowz4s 345 12 an an DT cord-331066-ediowz4s 345 13 RNA RNA NNP cord-331066-ediowz4s 345 14 packaging packaging NN cord-331066-ediowz4s 345 15 signal signal NN cord-331066-ediowz4s 345 16 and and CC cord-331066-ediowz4s 345 17 a a DT cord-331066-ediowz4s 345 18 viral viral JJ cord-331066-ediowz4s 345 19 envelope envelope NN cord-331066-ediowz4s 345 20 protein protein NN cord-331066-ediowz4s 345 21 in in IN cord-331066-ediowz4s 345 22 coronavirus coronavirus NN cord-331066-ediowz4s 345 23 RNA RNA NNP cord-331066-ediowz4s 345 24 packaging packaging NN cord-331066-ediowz4s 345 25 Supramolecular Supramolecular NNP cord-331066-ediowz4s 345 26 architecture architecture NN cord-331066-ediowz4s 345 27 of of IN cord-331066-ediowz4s 345 28 the the DT cord-331066-ediowz4s 345 29 coronavirus coronavirus NN cord-331066-ediowz4s 345 30 particle particle NN cord-331066-ediowz4s 345 31 In in IN cord-331066-ediowz4s 345 32 Medical medical JJ cord-331066-ediowz4s 345 33 virology virology NN cord-331066-ediowz4s 345 34 : : : cord-331066-ediowz4s 345 35 From from IN cord-331066-ediowz4s 345 36 pathogenesis pathogenesis NN cord-331066-ediowz4s 345 37 to to IN cord-331066-ediowz4s 345 38 disease disease NN cord-331066-ediowz4s 345 39 control control VB cord-331066-ediowz4s 345 40 Helical Helical NNP cord-331066-ediowz4s 345 41 capsids capsid NNS cord-331066-ediowz4s 345 42 of of IN cord-331066-ediowz4s 345 43 plant plant NN cord-331066-ediowz4s 345 44 viruses virus NNS cord-331066-ediowz4s 345 45 : : : cord-331066-ediowz4s 345 46 Architecture architecture NN cord-331066-ediowz4s 345 47 with with IN cord-331066-ediowz4s 345 48 structural structural JJ cord-331066-ediowz4s 345 49 lability lability NN cord-331066-ediowz4s 345 50 Bacteriophage Bacteriophage NNP cord-331066-ediowz4s 345 51 MS2 MS2 NNP cord-331066-ediowz4s 345 52 genomic genomic JJ cord-331066-ediowz4s 345 53 RNA RNA NNP cord-331066-ediowz4s 345 54 encodes encode VBZ cord-331066-ediowz4s 345 55 an an DT cord-331066-ediowz4s 345 56 assembly assembly NN cord-331066-ediowz4s 345 57 instruction instruction NN cord-331066-ediowz4s 345 58 manual manual NN cord-331066-ediowz4s 345 59 for for IN cord-331066-ediowz4s 345 60 its -PRON- PRP$ cord-331066-ediowz4s 345 61 capsid capsid JJ cord-331066-ediowz4s 345 62 Helical helical JJ cord-331066-ediowz4s 345 63 viruses virus NNS cord-331066-ediowz4s 345 64 Satellites satellite NNS cord-331066-ediowz4s 345 65 in in IN cord-331066-ediowz4s 345 66 the the DT cord-331066-ediowz4s 345 67 prokaryote prokaryote NN cord-331066-ediowz4s 345 68 world world NN cord-331066-ediowz4s 345 69 Comparative Comparative NNP cord-331066-ediowz4s 345 70 analysis analysis NN cord-331066-ediowz4s 345 71 of of IN cord-331066-ediowz4s 345 72 periodicity periodicity NN cord-331066-ediowz4s 345 73 search search NN cord-331066-ediowz4s 345 74 methods method NNS cord-331066-ediowz4s 345 75 in in IN cord-331066-ediowz4s 345 76 DNA dna NN cord-331066-ediowz4s 345 77 sequences sequence NNS cord-331066-ediowz4s 345 78 Short short JJ cord-331066-ediowz4s 345 79 tandem tandem NN cord-331066-ediowz4s 345 80 repeat repeat NN cord-331066-ediowz4s 345 81 expansions expansion NNS cord-331066-ediowz4s 345 82 and and CC cord-331066-ediowz4s 345 83 RNA rna NN cord-331066-ediowz4s 345 84 - - HYPH cord-331066-ediowz4s 345 85 mediated mediate VBN cord-331066-ediowz4s 345 86 pathogenesis pathogenesis NN cord-331066-ediowz4s 345 87 in in IN cord-331066-ediowz4s 345 88 myotonic myotonic JJ cord-331066-ediowz4s 345 89 dystrophy dystrophy NN cord-331066-ediowz4s 346 1 On on IN cord-331066-ediowz4s 346 2 the the DT cord-331066-ediowz4s 346 3 origin origin NN cord-331066-ediowz4s 346 4 and and CC cord-331066-ediowz4s 346 5 continuing continue VBG cord-331066-ediowz4s 346 6 evolution evolution NN cord-331066-ediowz4s 346 7 of of IN cord-331066-ediowz4s 346 8 SARS SARS NNP cord-331066-ediowz4s 346 9 - - HYPH cord-331066-ediowz4s 346 10 CoV-2 CoV-2 NNP cord-331066-ediowz4s 346 11 Comparative comparative JJ cord-331066-ediowz4s 346 12 computational computational JJ cord-331066-ediowz4s 346 13 analysis analysis NN cord-331066-ediowz4s 346 14 of of IN cord-331066-ediowz4s 346 15 SARS SARS NNP cord-331066-ediowz4s 346 16 - - HYPH cord-331066-ediowz4s 346 17 CoV-2 CoV-2 NNP cord-331066-ediowz4s 346 18 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 346 19 protein protein NN cord-331066-ediowz4s 346 20 epitopes epitope NNS cord-331066-ediowz4s 346 21 in in IN cord-331066-ediowz4s 346 22 taxonomically taxonomically RB cord-331066-ediowz4s 346 23 related relate VBN cord-331066-ediowz4s 346 24 coronaviruses coronaviruse NNS cord-331066-ediowz4s 347 1 A a DT cord-331066-ediowz4s 347 2 modelling modelling NN cord-331066-ediowz4s 347 3 paradigm paradigm NN cord-331066-ediowz4s 347 4 for for IN cord-331066-ediowz4s 347 5 RNA RNA NNP cord-331066-ediowz4s 347 6 virus virus NN cord-331066-ediowz4s 347 7 assembly assembly NN cord-331066-ediowz4s 347 8 . . . cord-331066-ediowz4s 348 1 Current current JJ cord-331066-ediowz4s 348 2 Opinion opinion NN cord-331066-ediowz4s 348 3 in in IN cord-331066-ediowz4s 348 4 Virology Virology NNP cord-331066-ediowz4s 349 1 The the DT cord-331066-ediowz4s 349 2 coronavirus coronavirus NN cord-331066-ediowz4s 349 3 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 349 4 protein protein NN cord-331066-ediowz4s 349 5 is be VBZ cord-331066-ediowz4s 349 6 dynamically dynamically RB cord-331066-ediowz4s 349 7 associated associate VBN cord-331066-ediowz4s 349 8 with with IN cord-331066-ediowz4s 349 9 the the DT cord-331066-ediowz4s 349 10 replication replication NN cord-331066-ediowz4s 349 11 - - HYPH cord-331066-ediowz4s 349 12 transcription transcription NN cord-331066-ediowz4s 349 13 complexes complex NNS cord-331066-ediowz4s 350 1 An an DT cord-331066-ediowz4s 350 2 in in IN cord-331066-ediowz4s 350 3 vivo vivo NNP cord-331066-ediowz4s 350 4 cellbased cellbased JJ cord-331066-ediowz4s 350 5 assay assay NN cord-331066-ediowz4s 350 6 for for IN cord-331066-ediowz4s 350 7 investigating investigate VBG cord-331066-ediowz4s 350 8 the the DT cord-331066-ediowz4s 350 9 specific specific JJ cord-331066-ediowz4s 350 10 interaction interaction NN cord-331066-ediowz4s 350 11 between between IN cord-331066-ediowz4s 350 12 the the DT cord-331066-ediowz4s 350 13 SARS SARS NNP cord-331066-ediowz4s 350 14 - - HYPH cord-331066-ediowz4s 350 15 CoV CoV NNP cord-331066-ediowz4s 350 16 N N NNP cord-331066-ediowz4s 350 17 - - HYPH cord-331066-ediowz4s 350 18 protein protein NN cord-331066-ediowz4s 350 19 and and CC cord-331066-ediowz4s 350 20 its -PRON- PRP$ cord-331066-ediowz4s 350 21 viral viral JJ cord-331066-ediowz4s 350 22 RNA RNA NNP cord-331066-ediowz4s 350 23 packaging packaging NN cord-331066-ediowz4s 350 24 sequence sequence NN cord-331066-ediowz4s 350 25 Insight Insight NNP cord-331066-ediowz4s 350 26 into into IN cord-331066-ediowz4s 350 27 2019 2019 CD cord-331066-ediowz4s 350 28 novel novel NN cord-331066-ediowz4s 350 29 coronavirus coronavirus NN cord-331066-ediowz4s 351 1 -An -An : cord-331066-ediowz4s 351 2 updated update VBN cord-331066-ediowz4s 351 3 interim interim JJ cord-331066-ediowz4s 351 4 review review NN cord-331066-ediowz4s 351 5 and and CC cord-331066-ediowz4s 351 6 lessons lesson NNS cord-331066-ediowz4s 351 7 from from IN cord-331066-ediowz4s 351 8 SARS SARS NNP cord-331066-ediowz4s 351 9 - - HYPH cord-331066-ediowz4s 351 10 CoV CoV NNP cord-331066-ediowz4s 351 11 and and CC cord-331066-ediowz4s 351 12 MERS MERS NNP cord-331066-ediowz4s 351 13 - - HYPH cord-331066-ediowz4s 351 14 CoV CoV NNP cord-331066-ediowz4s 351 15 Virtual virtual JJ cord-331066-ediowz4s 351 16 screening screening NN cord-331066-ediowz4s 351 17 and and CC cord-331066-ediowz4s 351 18 dynamics dynamic NNS cord-331066-ediowz4s 351 19 of of IN cord-331066-ediowz4s 351 20 potential potential JJ cord-331066-ediowz4s 351 21 inhibitors inhibitor NNS cord-331066-ediowz4s 351 22 targeting target VBG cord-331066-ediowz4s 351 23 RNA rna NN cord-331066-ediowz4s 351 24 binding binding NN cord-331066-ediowz4s 351 25 domain domain NN cord-331066-ediowz4s 351 26 of of IN cord-331066-ediowz4s 351 27 nucleocapsid nucleocapsid NN cord-331066-ediowz4s 351 28 phosphoprotein phosphoprotein NNP cord-331066-ediowz4s 351 29 from from IN cord-331066-ediowz4s 351 30 SARS SARS NNP cord-331066-ediowz4s 351 31 - - HYPH cord-331066-ediowz4s 351 32 CoV-2 CoV-2 NNP cord-331066-ediowz4s 351 33 Coronaviruses Coronaviruses NNPS cord-331066-ediowz4s 351 34 Limit Limit NNP cord-331066-ediowz4s 351 35 distributions distribution NNS cord-331066-ediowz4s 351 36 of of IN cord-331066-ediowz4s 351 37 random random JJ cord-331066-ediowz4s 351 38 variables variable NNS cord-331066-ediowz4s 351 39 associated associate VBN cord-331066-ediowz4s 351 40 with with IN cord-331066-ediowz4s 351 41 long long JJ cord-331066-ediowz4s 351 42 duplications duplication NNS cord-331066-ediowz4s 351 43 in in IN cord-331066-ediowz4s 351 44 a a DT cord-331066-ediowz4s 351 45 sequence sequence NN cord-331066-ediowz4s 351 46 of of IN cord-331066-ediowz4s 351 47 independent independent JJ cord-331066-ediowz4s 351 48 trials trial NNS