id	sid	tid	token	lemma	pos
cord-341050-hnuogpqn	1	1	key	key	NN
cord-341050-hnuogpqn	1	2	:	:	:
cord-341050-hnuogpqn	2	1	cord-341050-hnuogpqn	cord-341050-hnuogpqn	NNP
cord-341050-hnuogpqn	2	2	authors	author	NNS
cord-341050-hnuogpqn	2	3	:	:	:
cord-341050-hnuogpqn	2	4	Acharya	Acharya	NNP
cord-341050-hnuogpqn	2	5	,	,	,
cord-341050-hnuogpqn	2	6	Dhiraj	Dhiraj	NNP
cord-341050-hnuogpqn	2	7	;	;	:
cord-341050-hnuogpqn	2	8	Bai	Bai	NNP
cord-341050-hnuogpqn	2	9	,	,	,
cord-341050-hnuogpqn	2	10	Fengwei	Fengwei	NNP
cord-341050-hnuogpqn	2	11	title	title	NN
cord-341050-hnuogpqn	2	12	:	:	:
cord-341050-hnuogpqn	3	1	An	an	DT
cord-341050-hnuogpqn	3	2	Overview	Overview	NNP
cord-341050-hnuogpqn	3	3	of	of	IN
cord-341050-hnuogpqn	3	4	Current	current	JJ
cord-341050-hnuogpqn	3	5	Approaches	approach	NNS
cord-341050-hnuogpqn	3	6	Toward	toward	IN
cord-341050-hnuogpqn	3	7	the	the	DT
cord-341050-hnuogpqn	3	8	Treatment	Treatment	NNP
cord-341050-hnuogpqn	3	9	and	and	CC
cord-341050-hnuogpqn	3	10	Prevention	Prevention	NNP
cord-341050-hnuogpqn	3	11	of	of	IN
cord-341050-hnuogpqn	3	12	West	West	NNP
cord-341050-hnuogpqn	3	13	Nile	Nile	NNP
cord-341050-hnuogpqn	3	14	Virus	Virus	NNP
cord-341050-hnuogpqn	3	15	Infection	Infection	NNP
cord-341050-hnuogpqn	3	16	date	date	NN
cord-341050-hnuogpqn	3	17	:	:	:
cord-341050-hnuogpqn	3	18	2016	2016	CD
cord-341050-hnuogpqn	3	19	-	-	HYPH
cord-341050-hnuogpqn	3	20	05	05	CD
cord-341050-hnuogpqn	3	21	-	-	SYM
cord-341050-hnuogpqn	3	22	18	18	CD
cord-341050-hnuogpqn	3	23	journal	journal	NN
cord-341050-hnuogpqn	3	24	:	:	:
cord-341050-hnuogpqn	4	1	West	West	NNP
cord-341050-hnuogpqn	4	2	Nile	Nile	NNP
cord-341050-hnuogpqn	4	3	Virus	Virus	NNP
cord-341050-hnuogpqn	4	4	DOI	doi	NN
cord-341050-hnuogpqn	4	5	:	:	:
cord-341050-hnuogpqn	4	6	10.1007/978	10.1007/978	CD
cord-341050-hnuogpqn	4	7	-	-	HYPH
cord-341050-hnuogpqn	4	8	1	1	CD
cord-341050-hnuogpqn	4	9	-	-	HYPH
cord-341050-hnuogpqn	4	10	4939	4939	CD
cord-341050-hnuogpqn	4	11	-	-	HYPH
cord-341050-hnuogpqn	4	12	3670	3670	CD
cord-341050-hnuogpqn	4	13	-	-	HYPH
cord-341050-hnuogpqn	4	14	0_19	0_19	CD
cord-341050-hnuogpqn	5	1	sha	sha	NNP
cord-341050-hnuogpqn	5	2	:	:	:
cord-341050-hnuogpqn	5	3	96fa7b0201a495e59794b2b1c2e8cd794d1ba413	96fa7b0201a495e59794b2b1c2e8cd794d1ba413	CD
cord-341050-hnuogpqn	5	4	doc_id	doc_id	CD
cord-341050-hnuogpqn	5	5	:	:	:
cord-341050-hnuogpqn	6	1	341050	341050	CD
cord-341050-hnuogpqn	6	2	cord_uid	cord_uid	NNS
cord-341050-hnuogpqn	6	3	:	:	:
cord-341050-hnuogpqn	6	4	hnuogpqn	hnuogpqn	NNP
cord-341050-hnuogpqn	7	1	The	the	DT
cord-341050-hnuogpqn	7	2	persistence	persistence	NN
cord-341050-hnuogpqn	7	3	of	of	IN
cord-341050-hnuogpqn	7	4	West	West	NNP
cord-341050-hnuogpqn	7	5	Nile	Nile	NNP
cord-341050-hnuogpqn	7	6	virus	virus	NN
cord-341050-hnuogpqn	7	7	(	(	-LRB-
cord-341050-hnuogpqn	7	8	WNV	WNV	NNP
cord-341050-hnuogpqn	7	9	)	)	-RRB-
cord-341050-hnuogpqn	7	10	infections	infection	NNS
cord-341050-hnuogpqn	7	11	throughout	throughout	IN
cord-341050-hnuogpqn	7	12	the	the	DT
cord-341050-hnuogpqn	7	13	USA	USA	NNP
cord-341050-hnuogpqn	7	14	since	since	IN
cord-341050-hnuogpqn	7	15	its	-PRON-	PRP$
cord-341050-hnuogpqn	7	16	inception	inception	NN
cord-341050-hnuogpqn	7	17	in	in	IN
cord-341050-hnuogpqn	7	18	1999	1999	CD
cord-341050-hnuogpqn	7	19	and	and	CC
cord-341050-hnuogpqn	7	20	its	-PRON-	PRP$
cord-341050-hnuogpqn	7	21	continuous	continuous	JJ
cord-341050-hnuogpqn	7	22	spread	spread	NN
cord-341050-hnuogpqn	7	23	throughout	throughout	IN
cord-341050-hnuogpqn	7	24	the	the	DT
cord-341050-hnuogpqn	7	25	globe	globe	NN
cord-341050-hnuogpqn	7	26	calls	call	VBZ
cord-341050-hnuogpqn	7	27	for	for	IN
cord-341050-hnuogpqn	7	28	an	an	DT
cord-341050-hnuogpqn	7	29	urgent	urgent	JJ
cord-341050-hnuogpqn	7	30	need	need	NN
cord-341050-hnuogpqn	7	31	of	of	IN
cord-341050-hnuogpqn	7	32	effective	effective	JJ
cord-341050-hnuogpqn	7	33	treatments	treatment	NNS
cord-341050-hnuogpqn	7	34	and	and	CC
cord-341050-hnuogpqn	7	35	prevention	prevention	NN
cord-341050-hnuogpqn	7	36	measures	measure	NNS
cord-341050-hnuogpqn	7	37	.	.	.
cord-341050-hnuogpqn	8	1	Although	although	IN
cord-341050-hnuogpqn	8	2	the	the	DT
cord-341050-hnuogpqn	8	3	licensing	licensing	NN
cord-341050-hnuogpqn	8	4	of	of	IN
cord-341050-hnuogpqn	8	5	several	several	JJ
cord-341050-hnuogpqn	8	6	WNV	WNV	NNP
cord-341050-hnuogpqn	8	7	vaccines	vaccine	NNS
cord-341050-hnuogpqn	8	8	for	for	IN
cord-341050-hnuogpqn	8	9	veterinary	veterinary	JJ
cord-341050-hnuogpqn	8	10	use	use	NN
cord-341050-hnuogpqn	8	11	provides	provide	VBZ
cord-341050-hnuogpqn	8	12	a	a	DT
cord-341050-hnuogpqn	8	13	proof	proof	NN
cord-341050-hnuogpqn	8	14	of	of	IN
cord-341050-hnuogpqn	8	15	concept	concept	NN
cord-341050-hnuogpqn	8	16	,	,	,
cord-341050-hnuogpqn	8	17	similar	similar	JJ
cord-341050-hnuogpqn	8	18	efforts	effort	NNS
cord-341050-hnuogpqn	8	19	on	on	IN
cord-341050-hnuogpqn	8	20	the	the	DT
cord-341050-hnuogpqn	8	21	development	development	NN
cord-341050-hnuogpqn	8	22	of	of	IN
cord-341050-hnuogpqn	8	23	an	an	DT
cord-341050-hnuogpqn	8	24	effective	effective	JJ
cord-341050-hnuogpqn	8	25	vaccine	vaccine	NN
cord-341050-hnuogpqn	8	26	for	for	IN
cord-341050-hnuogpqn	8	27	humans	human	NNS
cord-341050-hnuogpqn	8	28	remain	remain	VBP
cord-341050-hnuogpqn	8	29	still	still	RB
cord-341050-hnuogpqn	8	30	unsuccessful	unsuccessful	JJ
cord-341050-hnuogpqn	8	31	.	.	.
cord-341050-hnuogpqn	9	1	Increased	increase	VBN
cord-341050-hnuogpqn	9	2	understanding	understanding	NN
cord-341050-hnuogpqn	9	3	of	of	IN
cord-341050-hnuogpqn	9	4	biology	biology	NN
cord-341050-hnuogpqn	9	5	and	and	CC
cord-341050-hnuogpqn	9	6	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	9	7	of	of	IN
cord-341050-hnuogpqn	9	8	WNV	WNV	NNP
cord-341050-hnuogpqn	9	9	together	together	RB
cord-341050-hnuogpqn	9	10	with	with	IN
cord-341050-hnuogpqn	9	11	recent	recent	JJ
cord-341050-hnuogpqn	9	12	technological	technological	JJ
cord-341050-hnuogpqn	9	13	advancements	advancement	NNS
cord-341050-hnuogpqn	9	14	have	have	VBP
cord-341050-hnuogpqn	9	15	raised	raise	VBN
cord-341050-hnuogpqn	9	16	hope	hope	NN
cord-341050-hnuogpqn	9	17	that	that	IN
cord-341050-hnuogpqn	9	18	an	an	DT
cord-341050-hnuogpqn	9	19	effective	effective	JJ
cord-341050-hnuogpqn	9	20	WNV	WNV	NNP
cord-341050-hnuogpqn	9	21	vaccine	vaccine	NN
cord-341050-hnuogpqn	9	22	may	may	MD
cord-341050-hnuogpqn	9	23	be	be	VB
cord-341050-hnuogpqn	9	24	available	available	JJ
cord-341050-hnuogpqn	9	25	in	in	IN
cord-341050-hnuogpqn	9	26	the	the	DT
cord-341050-hnuogpqn	9	27	near	near	JJ
cord-341050-hnuogpqn	9	28	future	future	NN
cord-341050-hnuogpqn	9	29	.	.	.
cord-341050-hnuogpqn	10	1	In	in	IN
cord-341050-hnuogpqn	10	2	addition	addition	NN
cord-341050-hnuogpqn	10	3	,	,	,
cord-341050-hnuogpqn	10	4	rapid	rapid	JJ
cord-341050-hnuogpqn	10	5	progress	progress	NN
cord-341050-hnuogpqn	10	6	in	in	IN
cord-341050-hnuogpqn	10	7	the	the	DT
cord-341050-hnuogpqn	10	8	structural	structural	JJ
cord-341050-hnuogpqn	10	9	and	and	CC
cord-341050-hnuogpqn	10	10	functional	functional	JJ
cord-341050-hnuogpqn	10	11	characterization	characterization	NN
cord-341050-hnuogpqn	10	12	of	of	IN
cord-341050-hnuogpqn	10	13	WNV	WNV	NNP
cord-341050-hnuogpqn	10	14	and	and	CC
cord-341050-hnuogpqn	10	15	other	other	JJ
cord-341050-hnuogpqn	10	16	flaviviral	flaviviral	JJ
cord-341050-hnuogpqn	10	17	proteins	protein	NNS
cord-341050-hnuogpqn	10	18	have	have	VBP
cord-341050-hnuogpqn	10	19	provided	provide	VBN
cord-341050-hnuogpqn	10	20	a	a	DT
cord-341050-hnuogpqn	10	21	solid	solid	JJ
cord-341050-hnuogpqn	10	22	base	base	NN
cord-341050-hnuogpqn	10	23	for	for	IN
cord-341050-hnuogpqn	10	24	the	the	DT
cord-341050-hnuogpqn	10	25	design	design	NN
cord-341050-hnuogpqn	10	26	and	and	CC
cord-341050-hnuogpqn	10	27	development	development	NN
cord-341050-hnuogpqn	10	28	of	of	IN
cord-341050-hnuogpqn	10	29	several	several	JJ
cord-341050-hnuogpqn	10	30	classes	class	NNS
cord-341050-hnuogpqn	10	31	of	of	IN
cord-341050-hnuogpqn	10	32	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	10	33	as	as	IN
cord-341050-hnuogpqn	10	34	potential	potential	JJ
cord-341050-hnuogpqn	10	35	WNV	WNV	NNP
cord-341050-hnuogpqn	10	36	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	10	37	.	.	.
cord-341050-hnuogpqn	11	1	Moreover	moreover	RB
cord-341050-hnuogpqn	11	2	,	,	,
cord-341050-hnuogpqn	11	3	the	the	DT
cord-341050-hnuogpqn	11	4	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	11	5	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	11	6	antibodies	antibody	NNS
cord-341050-hnuogpqn	11	7	demonstrate	demonstrate	VBP
cord-341050-hnuogpqn	11	8	an	an	DT
cord-341050-hnuogpqn	11	9	excellent	excellent	JJ
cord-341050-hnuogpqn	11	10	efficacy	efficacy	NN
cord-341050-hnuogpqn	11	11	against	against	IN
cord-341050-hnuogpqn	11	12	WNV	WNV	NNP
cord-341050-hnuogpqn	11	13	in	in	IN
cord-341050-hnuogpqn	11	14	animal	animal	NN
cord-341050-hnuogpqn	11	15	models	model	NNS
cord-341050-hnuogpqn	11	16	and	and	CC
cord-341050-hnuogpqn	11	17	represent	represent	VBP
cord-341050-hnuogpqn	11	18	a	a	DT
cord-341050-hnuogpqn	11	19	promising	promising	JJ
cord-341050-hnuogpqn	11	20	class	class	NN
cord-341050-hnuogpqn	11	21	of	of	IN
cord-341050-hnuogpqn	11	22	WNV	WNV	NNP
cord-341050-hnuogpqn	11	23	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	11	24	.	.	.
cord-341050-hnuogpqn	12	1	However	however	RB
cord-341050-hnuogpqn	12	2	,	,	,
cord-341050-hnuogpqn	12	3	there	there	EX
cord-341050-hnuogpqn	12	4	are	be	VBP
cord-341050-hnuogpqn	12	5	some	some	DT
cord-341050-hnuogpqn	12	6	challenges	challenge	NNS
cord-341050-hnuogpqn	12	7	as	as	IN
cord-341050-hnuogpqn	12	8	to	to	IN
cord-341050-hnuogpqn	12	9	the	the	DT
cord-341050-hnuogpqn	12	10	design	design	NN
cord-341050-hnuogpqn	12	11	and	and	CC
cord-341050-hnuogpqn	12	12	development	development	NN
cord-341050-hnuogpqn	12	13	of	of	IN
cord-341050-hnuogpqn	12	14	a	a	DT
cord-341050-hnuogpqn	12	15	safe	safe	JJ
cord-341050-hnuogpqn	12	16	and	and	CC
cord-341050-hnuogpqn	12	17	efficient	efficient	JJ
cord-341050-hnuogpqn	12	18	WNV	WNV	NNP
cord-341050-hnuogpqn	12	19	vaccine	vaccine	NN
cord-341050-hnuogpqn	12	20	or	or	CC
cord-341050-hnuogpqn	12	21	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	12	22	.	.	.
cord-341050-hnuogpqn	13	1	In	in	IN
cord-341050-hnuogpqn	13	2	this	this	DT
cord-341050-hnuogpqn	13	3	chapter	chapter	NN
cord-341050-hnuogpqn	13	4	,	,	,
cord-341050-hnuogpqn	13	5	we	-PRON-	PRP
cord-341050-hnuogpqn	13	6	discuss	discuss	VBP
cord-341050-hnuogpqn	13	7	the	the	DT
cord-341050-hnuogpqn	13	8	current	current	JJ
cord-341050-hnuogpqn	13	9	approaches	approach	NNS
cord-341050-hnuogpqn	13	10	,	,	,
cord-341050-hnuogpqn	13	11	progress	progress	NN
cord-341050-hnuogpqn	13	12	,	,	,
cord-341050-hnuogpqn	13	13	and	and	CC
cord-341050-hnuogpqn	13	14	challenges	challenge	NNS
cord-341050-hnuogpqn	13	15	toward	toward	IN
cord-341050-hnuogpqn	13	16	the	the	DT
cord-341050-hnuogpqn	13	17	development	development	NN
cord-341050-hnuogpqn	13	18	of	of	IN
cord-341050-hnuogpqn	13	19	WNV	WNV	NNP
cord-341050-hnuogpqn	13	20	vaccines	vaccine	NNS
cord-341050-hnuogpqn	13	21	,	,	,
cord-341050-hnuogpqn	13	22	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	13	23	antibodies	antibody	NNS
cord-341050-hnuogpqn	13	24	,	,	,
cord-341050-hnuogpqn	13	25	and	and	CC
cord-341050-hnuogpqn	13	26	antiviral	antiviral	JJ
cord-341050-hnuogpqn	13	27	drugs	drug	NNS
cord-341050-hnuogpqn	13	28	.	.	.
cord-341050-hnuogpqn	14	1	may	may	MD
cord-341050-hnuogpqn	14	2	cause	cause	VB
cord-341050-hnuogpqn	14	3	injury	injury	NN
cord-341050-hnuogpqn	14	4	and	and	CC
cord-341050-hnuogpqn	14	5	death	death	NN
cord-341050-hnuogpqn	14	6	of	of	IN
cord-341050-hnuogpqn	14	7	neurons	neuron	NNS
cord-341050-hnuogpqn	14	8	with	with	IN
cord-341050-hnuogpqn	14	9	various	various	JJ
cord-341050-hnuogpqn	14	10	clinical	clinical	JJ
cord-341050-hnuogpqn	14	11	manifestations	manifestation	NNS
cord-341050-hnuogpqn	14	12	,	,	,
cord-341050-hnuogpqn	14	13	such	such	JJ
cord-341050-hnuogpqn	14	14	as	as	IN
cord-341050-hnuogpqn	14	15	encephalitis	encephalitis	NN
cord-341050-hnuogpqn	14	16	,	,	,
cord-341050-hnuogpqn	14	17	meningitis	meningitis	NN
cord-341050-hnuogpqn	14	18	,	,	,
cord-341050-hnuogpqn	14	19	fl	fl	NNP
cord-341050-hnuogpqn	14	20	accid	accid	JJ
cord-341050-hnuogpqn	14	21	paralysis	paralysis	NN
cord-341050-hnuogpqn	14	22	,	,	,
cord-341050-hnuogpqn	14	23	persistent	persistent	JJ
cord-341050-hnuogpqn	14	24	neurologic	neurologic	JJ
cord-341050-hnuogpqn	14	25	sequelae	sequela	NNS
cord-341050-hnuogpqn	14	26	,	,	,
cord-341050-hnuogpqn	14	27	and	and	CC
cord-341050-hnuogpqn	14	28	possibly	possibly	RB
cord-341050-hnuogpqn	14	29	death	death	NN
cord-341050-hnuogpqn	14	30	,	,	,
cord-341050-hnuogpqn	14	31	particularly	particularly	RB
cord-341050-hnuogpqn	14	32	in	in	IN
cord-341050-hnuogpqn	14	33	the	the	DT
cord-341050-hnuogpqn	14	34	elderly	elderly	JJ
cord-341050-hnuogpqn	14	35	and	and	CC
cord-341050-hnuogpqn	14	36	immunocompromised	immunocompromised	JJ
cord-341050-hnuogpqn	14	37	individuals	individual	NNS
cord-341050-hnuogpqn	14	38	[	[	-LRB-
cord-341050-hnuogpqn	14	39	1	1	CD
cord-341050-hnuogpqn	14	40	,	,	,
cord-341050-hnuogpqn	14	41	10	10	CD
cord-341050-hnuogpqn	14	42	,	,	,
cord-341050-hnuogpqn	14	43	11	11	CD
cord-341050-hnuogpqn	14	44	]	]	-RRB-
cord-341050-hnuogpqn	14	45	.	.	.
cord-341050-hnuogpqn	15	1	WNV	WNV	NNP
cord-341050-hnuogpqn	15	2	strongly	strongly	RB
cord-341050-hnuogpqn	15	3	activates	activate	VBZ
cord-341050-hnuogpqn	15	4	host	host	NN
cord-341050-hnuogpqn	15	5	immune	immune	JJ
cord-341050-hnuogpqn	15	6	responses	response	NNS
cord-341050-hnuogpqn	15	7	,	,	,
cord-341050-hnuogpqn	15	8	which	which	WDT
cord-341050-hnuogpqn	15	9	play	play	VBP
cord-341050-hnuogpqn	15	10	important	important	JJ
cord-341050-hnuogpqn	15	11	roles	role	NNS
cord-341050-hnuogpqn	15	12	in	in	IN
cord-341050-hnuogpqn	15	13	controlling	control	VBG
cord-341050-hnuogpqn	15	14	viremia	viremia	NN
cord-341050-hnuogpqn	15	15	,	,	,
cord-341050-hnuogpqn	15	16	viral	viral	JJ
cord-341050-hnuogpqn	15	17	dissemination	dissemination	NN
cord-341050-hnuogpqn	15	18	to	to	IN
cord-341050-hnuogpqn	15	19	the	the	DT
cord-341050-hnuogpqn	15	20	central	central	JJ
cord-341050-hnuogpqn	15	21	nervous	nervous	JJ
cord-341050-hnuogpqn	15	22	system	system	NN
cord-341050-hnuogpqn	15	23	(	(	-LRB-
cord-341050-hnuogpqn	15	24	CNS	CNS	NNP
cord-341050-hnuogpqn	15	25	)	)	-RRB-
cord-341050-hnuogpqn	15	26	,	,	,
cord-341050-hnuogpqn	15	27	and	and	CC
cord-341050-hnuogpqn	15	28	recovery	recovery	NN
cord-341050-hnuogpqn	15	29	from	from	IN
cord-341050-hnuogpqn	15	30	the	the	DT
cord-341050-hnuogpqn	15	31	disease	disease	NN
cord-341050-hnuogpqn	15	32	[	[	-LRB-
cord-341050-hnuogpqn	15	33	11	11	CD
cord-341050-hnuogpqn	15	34	]	]	-RRB-
cord-341050-hnuogpqn	15	35	.	.	.
cord-341050-hnuogpqn	16	1	However	however	RB
cord-341050-hnuogpqn	16	2	,	,	,
cord-341050-hnuogpqn	16	3	the	the	DT
cord-341050-hnuogpqn	16	4	mechanism	mechanism	NN
cord-341050-hnuogpqn	16	5	of	of	IN
cord-341050-hnuogpqn	16	6	WNV	WNV	NNP
cord-341050-hnuogpqn	16	7	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	16	8	,	,	,
cord-341050-hnuogpqn	16	9	including	include	VBG
cord-341050-hnuogpqn	16	10	its	-PRON-	PRP$
cord-341050-hnuogpqn	16	11	tropism	tropism	NN
cord-341050-hnuogpqn	16	12	to	to	IN
cord-341050-hnuogpqn	16	13	neurons	neuron	NNS
cord-341050-hnuogpqn	16	14	,	,	,
cord-341050-hnuogpqn	16	15	CNS	CNS	NNP
cord-341050-hnuogpqn	16	16	invasion	invasion	NN
cord-341050-hnuogpqn	16	17	,	,	,
cord-341050-hnuogpqn	16	18	and	and	CC
cord-341050-hnuogpqn	16	19	viral	viral	JJ
cord-341050-hnuogpqn	16	20	or	or	CC
cord-341050-hnuogpqn	16	21	host	host	NN
cord-341050-hnuogpqn	16	22	factors	factor	NNS
cord-341050-hnuogpqn	16	23	that	that	WDT
cord-341050-hnuogpqn	16	24	contribute	contribute	VBP
cord-341050-hnuogpqn	16	25	to	to	IN
cord-341050-hnuogpqn	16	26	imbalance	imbalance	NN
cord-341050-hnuogpqn	16	27	between	between	IN
cord-341050-hnuogpqn	16	28	viral	viral	JJ
cord-341050-hnuogpqn	16	29	pathology	pathology	NN
cord-341050-hnuogpqn	16	30	and	and	CC
cord-341050-hnuogpqn	16	31	host	host	NN
cord-341050-hnuogpqn	16	32	immunity	immunity	NN
cord-341050-hnuogpqn	16	33	still	still	RB
cord-341050-hnuogpqn	16	34	remain	remain	VBP
cord-341050-hnuogpqn	16	35	poorly	poorly	RB
cord-341050-hnuogpqn	16	36	understood	understand	VBN
cord-341050-hnuogpqn	16	37	.	.	.
cord-341050-hnuogpqn	17	1	Although	although	IN
cord-341050-hnuogpqn	17	2	WNV	WNV	NNP
cord-341050-hnuogpqn	17	3	was	be	VBD
cord-341050-hnuogpqn	17	4	fi	fi	NNP
cord-341050-hnuogpqn	17	5	rst	rst	NNP
cord-341050-hnuogpqn	17	6	discovered	discover	VBN
cord-341050-hnuogpqn	17	7	in	in	IN
cord-341050-hnuogpqn	17	8	Uganda	Uganda	NNP
cord-341050-hnuogpqn	17	9	in	in	IN
cord-341050-hnuogpqn	17	10	1937	1937	CD
cord-341050-hnuogpqn	17	11	,	,	,
cord-341050-hnuogpqn	17	12	it	-PRON-	PRP
cord-341050-hnuogpqn	17	13	had	have	VBD
cord-341050-hnuogpqn	17	14	been	be	VBN
cord-341050-hnuogpqn	17	15	considered	consider	VBN
cord-341050-hnuogpqn	17	16	as	as	IN
cord-341050-hnuogpqn	17	17	a	a	DT
cord-341050-hnuogpqn	17	18	minor	minor	JJ
cord-341050-hnuogpqn	17	19	public	public	JJ
cord-341050-hnuogpqn	17	20	health	health	NN
cord-341050-hnuogpqn	17	21	concern	concern	NN
cord-341050-hnuogpqn	17	22	until	until	IN
cord-341050-hnuogpqn	17	23	its	-PRON-	PRP$
cord-341050-hnuogpqn	17	24	fi	fi	NN
cord-341050-hnuogpqn	17	25	rst	rst	NN
cord-341050-hnuogpqn	17	26	appearance	appearance	NN
cord-341050-hnuogpqn	17	27	in	in	IN
cord-341050-hnuogpqn	17	28	the	the	DT
cord-341050-hnuogpqn	17	29	USA	USA	NNP
cord-341050-hnuogpqn	17	30	in	in	IN
cord-341050-hnuogpqn	17	31	1999	1999	CD
cord-341050-hnuogpqn	17	32	[	[	-LRB-
cord-341050-hnuogpqn	17	33	12	12	CD
cord-341050-hnuogpqn	17	34	]	]	-RRB-
cord-341050-hnuogpqn	17	35	.	.	.
cord-341050-hnuogpqn	18	1	Since	since	IN
cord-341050-hnuogpqn	18	2	then	then	RB
cord-341050-hnuogpqn	18	3	,	,	,
cord-341050-hnuogpqn	18	4	it	-PRON-	PRP
cord-341050-hnuogpqn	18	5	has	have	VBZ
cord-341050-hnuogpqn	18	6	dramatically	dramatically	RB
cord-341050-hnuogpqn	18	7	spread	spread	VBN
cord-341050-hnuogpqn	18	8	to	to	IN
cord-341050-hnuogpqn	18	9	all	all	PDT
cord-341050-hnuogpqn	18	10	the	the	DT
cord-341050-hnuogpqn	18	11	continental	continental	JJ
cord-341050-hnuogpqn	18	12	states	state	NNS
cord-341050-hnuogpqn	18	13	of	of	IN
cord-341050-hnuogpqn	18	14	the	the	DT
cord-341050-hnuogpqn	18	15	USA	USA	NNP
cord-341050-hnuogpqn	18	16	and	and	CC
cord-341050-hnuogpqn	18	17	became	become	VBD
cord-341050-hnuogpqn	18	18	an	an	DT
cord-341050-hnuogpqn	18	19	endemic	endemic	JJ
cord-341050-hnuogpqn	18	20	disease	disease	NN
cord-341050-hnuogpqn	18	21	throughout	throughout	IN
cord-341050-hnuogpqn	18	22	North	North	NNP
cord-341050-hnuogpqn	18	23	America	America	NNP
cord-341050-hnuogpqn	18	24	within	within	IN
cord-341050-hnuogpqn	18	25	a	a	DT
cord-341050-hnuogpqn	18	26	few	few	JJ
cord-341050-hnuogpqn	18	27	years	year	NNS
cord-341050-hnuogpqn	18	28	[	[	-LRB-
cord-341050-hnuogpqn	18	29	13	13	CD
cord-341050-hnuogpqn	18	30	-16	-16	CD
cord-341050-hnuogpqn	18	31	]	]	-RRB-
cord-341050-hnuogpqn	18	32	.	.	.
cord-341050-hnuogpqn	19	1	In	in	IN
cord-341050-hnuogpqn	19	2	the	the	DT
cord-341050-hnuogpqn	19	3	USA	USA	NNP
cord-341050-hnuogpqn	19	4	alone	alone	RB
cord-341050-hnuogpqn	19	5	,	,	,
cord-341050-hnuogpqn	19	6	there	there	EX
cord-341050-hnuogpqn	19	7	have	have	VBP
cord-341050-hnuogpqn	19	8	been	be	VBN
cord-341050-hnuogpqn	19	9	over	over	IN
cord-341050-hnuogpqn	19	10	40,000	40,000	CD
cord-341050-hnuogpqn	19	11	reported	report	VBN
cord-341050-hnuogpqn	19	12	cases	case	NNS
cord-341050-hnuogpqn	19	13	of	of	IN
cord-341050-hnuogpqn	19	14	WNV	WNV	NNP
cord-341050-hnuogpqn	19	15	between	between	IN
cord-341050-hnuogpqn	19	16	1999	1999	CD
cord-341050-hnuogpqn	19	17	and	and	CC
cord-341050-hnuogpqn	19	18	2014	2014	CD
cord-341050-hnuogpqn	19	19	,	,	,
cord-341050-hnuogpqn	19	20	of	of	IN
cord-341050-hnuogpqn	19	21	which	which	WDT
cord-341050-hnuogpqn	19	22	~45	~45	CD
cord-341050-hnuogpqn	19	23	%	%	NN
cord-341050-hnuogpqn	19	24	were	be	VBD
cord-341050-hnuogpqn	19	25	classifi	classifi	NNP
cord-341050-hnuogpqn	19	26	ed	ed	NNP
cord-341050-hnuogpqn	19	27	as	as	IN
cord-341050-hnuogpqn	19	28	neuroinvasive	neuroinvasive	NNP
cord-341050-hnuogpqn	19	29	and	and	CC
cord-341050-hnuogpqn	19	30	claimed	claim	VBD
cord-341050-hnuogpqn	19	31	lives	life	NNS
cord-341050-hnuogpqn	19	32	of	of	IN
cord-341050-hnuogpqn	19	33	nearly	nearly	RB
cord-341050-hnuogpqn	19	34	two	two	CD
cord-341050-hnuogpqn	19	35	thousand	thousand	CD
cord-341050-hnuogpqn	19	36	people	people	NNS
cord-341050-hnuogpqn	19	37	[	[	-LRB-
cord-341050-hnuogpqn	19	38	17	17	CD
cord-341050-hnuogpqn	19	39	]	]	-RRB-
cord-341050-hnuogpqn	19	40	.	.	.
cord-341050-hnuogpqn	20	1	However	however	RB
cord-341050-hnuogpqn	20	2	,	,	,
cord-341050-hnuogpqn	20	3	the	the	DT
cord-341050-hnuogpqn	20	4	actual	actual	JJ
cord-341050-hnuogpqn	20	5	WNV	WNV	NNP
cord-341050-hnuogpqn	20	6	burden	burden	NN
cord-341050-hnuogpqn	20	7	is	be	VBZ
cord-341050-hnuogpqn	20	8	likely	likely	RB
cord-341050-hnuogpqn	20	9	much	much	RB
cord-341050-hnuogpqn	20	10	higher	high	JJR
cord-341050-hnuogpqn	20	11	than	than	IN
cord-341050-hnuogpqn	20	12	previously	previously	RB
cord-341050-hnuogpqn	20	13	thought	think	VBN
cord-341050-hnuogpqn	20	14	because	because	IN
cord-341050-hnuogpqn	20	15	only	only	RB
cord-341050-hnuogpqn	20	16	about	about	RB
cord-341050-hnuogpqn	20	17	20	20	CD
cord-341050-hnuogpqn	20	18	%	%	NN
cord-341050-hnuogpqn	20	19	of	of	IN
cord-341050-hnuogpqn	20	20	infected	infected	JJ
cord-341050-hnuogpqn	20	21	individual	individual	NN
cord-341050-hnuogpqn	20	22	develop	develop	VBP
cord-341050-hnuogpqn	20	23	a	a	DT
cord-341050-hnuogpqn	20	24	clinical	clinical	JJ
cord-341050-hnuogpqn	20	25	WNV	WNV	NNP
cord-341050-hnuogpqn	20	26	disease	disease	NN
cord-341050-hnuogpqn	20	27	[	[	-LRB-
cord-341050-hnuogpqn	20	28	13	13	CD
cord-341050-hnuogpqn	20	29	]	]	-RRB-
cord-341050-hnuogpqn	20	30	.	.	.
cord-341050-hnuogpqn	21	1	It	-PRON-	PRP
cord-341050-hnuogpqn	21	2	has	have	VBZ
cord-341050-hnuogpqn	21	3	been	be	VBN
cord-341050-hnuogpqn	21	4	estimated	estimate	VBN
cord-341050-hnuogpqn	21	5	that	that	IN
cord-341050-hnuogpqn	21	6	over	over	IN
cord-341050-hnuogpqn	21	7	three	three	CD
cord-341050-hnuogpqn	21	8	million	million	CD
cord-341050-hnuogpqn	21	9	individuals	individual	NNS
cord-341050-hnuogpqn	21	10	have	have	VBP
cord-341050-hnuogpqn	21	11	been	be	VBN
cord-341050-hnuogpqn	21	12	infected	infect	VBN
cord-341050-hnuogpqn	21	13	with	with	IN
cord-341050-hnuogpqn	21	14	WNV	WNV	NNP
cord-341050-hnuogpqn	21	15	in	in	IN
cord-341050-hnuogpqn	21	16	the	the	DT
cord-341050-hnuogpqn	21	17	USA	USA	NNP
cord-341050-hnuogpqn	21	18	,	,	,
cord-341050-hnuogpqn	21	19	of	of	IN
cord-341050-hnuogpqn	21	20	which	which	WDT
cord-341050-hnuogpqn	21	21	about	about	IN
cord-341050-hnuogpqn	21	22	780,000	780,000	CD
cord-341050-hnuogpqn	21	23	had	have	VBD
cord-341050-hnuogpqn	21	24	a	a	DT
cord-341050-hnuogpqn	21	25	symptomatic	symptomatic	JJ
cord-341050-hnuogpqn	21	26	disease	disease	NN
cord-341050-hnuogpqn	21	27	[	[	-LRB-
cord-341050-hnuogpqn	21	28	18	18	CD
cord-341050-hnuogpqn	21	29	]	]	-RRB-
cord-341050-hnuogpqn	21	30	.	.	.
cord-341050-hnuogpqn	22	1	WNV	WNV	NNP
cord-341050-hnuogpqn	22	2	also	also	RB
cord-341050-hnuogpqn	22	3	has	have	VBZ
cord-341050-hnuogpqn	22	4	potential	potential	NN
cord-341050-hnuogpqn	22	5	to	to	TO
cord-341050-hnuogpqn	22	6	develop	develop	VB
cord-341050-hnuogpqn	22	7	unusual	unusual	JJ
cord-341050-hnuogpqn	22	8	clinical	clinical	JJ
cord-341050-hnuogpqn	22	9	manifestations	manifestation	NNS
cord-341050-hnuogpqn	22	10	[	[	-LRB-
cord-341050-hnuogpqn	22	11	19	19	CD
cord-341050-hnuogpqn	22	12	-21	-21	NN
cord-341050-hnuogpqn	22	13	]	]	-RRB-
cord-341050-hnuogpqn	22	14	and	and	CC
cord-341050-hnuogpqn	22	15	may	may	MD
cord-341050-hnuogpqn	22	16	involve	involve	VB
cord-341050-hnuogpqn	22	17	in	in	IN
cord-341050-hnuogpqn	22	18	renal	renal	JJ
cord-341050-hnuogpqn	22	19	diseases	disease	NNS
cord-341050-hnuogpqn	22	20	[	[	-LRB-
cord-341050-hnuogpqn	22	21	22	22	CD
cord-341050-hnuogpqn	22	22	,	,	,
cord-341050-hnuogpqn	22	23	23	23	CD
cord-341050-hnuogpqn	22	24	]	]	-RRB-
cord-341050-hnuogpqn	22	25	,	,	,
cord-341050-hnuogpqn	22	26	myasthenia	myasthenia	NN
cord-341050-hnuogpqn	22	27	gravis	gravis	NN
cord-341050-hnuogpqn	22	28	[	[	-LRB-
cord-341050-hnuogpqn	22	29	24	24	CD
cord-341050-hnuogpqn	22	30	]	]	-RRB-
cord-341050-hnuogpqn	22	31	,	,	,
cord-341050-hnuogpqn	22	32	and	and	CC
cord-341050-hnuogpqn	22	33	myocarditis	myocarditis	NN
cord-341050-hnuogpqn	22	34	[	[	-LRB-
cord-341050-hnuogpqn	22	35	25	25	CD
cord-341050-hnuogpqn	22	36	]	]	-RRB-
cord-341050-hnuogpqn	22	37	,	,	,
cord-341050-hnuogpqn	22	38	suggesting	suggest	VBG
cord-341050-hnuogpqn	22	39	that	that	IN
cord-341050-hnuogpqn	22	40	the	the	DT
cord-341050-hnuogpqn	22	41	range	range	NN
cord-341050-hnuogpqn	22	42	and	and	CC
cord-341050-hnuogpqn	22	43	severity	severity	NN
cord-341050-hnuogpqn	22	44	of	of	IN
cord-341050-hnuogpqn	22	45	WNV	WNV	NNP
cord-341050-hnuogpqn	22	46	disease	disease	NN
cord-341050-hnuogpqn	22	47	may	may	MD
cord-341050-hnuogpqn	22	48	be	be	VB
cord-341050-hnuogpqn	22	49	even	even	RB
cord-341050-hnuogpqn	22	50	worse	bad	JJR
cord-341050-hnuogpqn	22	51	than	than	IN
cord-341050-hnuogpqn	22	52	previously	previously	RB
cord-341050-hnuogpqn	22	53	believed	believe	VBN
cord-341050-hnuogpqn	22	54	.	.	.
cord-341050-hnuogpqn	23	1	Importantly	importantly	RB
cord-341050-hnuogpqn	23	2	,	,	,
cord-341050-hnuogpqn	23	3	increasing	increase	VBG
cord-341050-hnuogpqn	23	4	numbers	number	NNS
cord-341050-hnuogpqn	23	5	of	of	IN
cord-341050-hnuogpqn	23	6	WNV	WNV	NNP
cord-341050-hnuogpqn	23	7	outbreaks	outbreak	NNS
cord-341050-hnuogpqn	23	8	during	during	IN
cord-341050-hnuogpqn	23	9	the	the	DT
cord-341050-hnuogpqn	23	10	last	last	JJ
cord-341050-hnuogpqn	23	11	15	15	CD
cord-341050-hnuogpqn	23	12	years	year	NNS
cord-341050-hnuogpqn	23	13	have	have	VBP
cord-341050-hnuogpqn	23	14	been	be	VBN
cord-341050-hnuogpqn	23	15	associated	associate	VBN
cord-341050-hnuogpqn	23	16	with	with	IN
cord-341050-hnuogpqn	23	17	greater	great	JJR
cord-341050-hnuogpqn	23	18	number	number	NN
cord-341050-hnuogpqn	23	19	of	of	IN
cord-341050-hnuogpqn	23	20	neuroinvasive	neuroinvasive	JJ
cord-341050-hnuogpqn	23	21	cases	case	NNS
cord-341050-hnuogpqn	23	22	and	and	CC
cord-341050-hnuogpqn	23	23	a	a	DT
cord-341050-hnuogpqn	23	24	higher	high	JJR
cord-341050-hnuogpqn	23	25	rate	rate	NN
cord-341050-hnuogpqn	23	26	of	of	IN
cord-341050-hnuogpqn	23	27	fatalities	fatality	NNS
cord-341050-hnuogpqn	23	28	[	[	-LRB-
cord-341050-hnuogpqn	23	29	16	16	CD
cord-341050-hnuogpqn	23	30	,	,	,
cord-341050-hnuogpqn	23	31	17	17	CD
cord-341050-hnuogpqn	23	32	]	]	-RRB-
cord-341050-hnuogpqn	23	33	.	.	.
cord-341050-hnuogpqn	24	1	However	however	RB
cord-341050-hnuogpqn	24	2	,	,	,
cord-341050-hnuogpqn	24	3	no	no	DT
cord-341050-hnuogpqn	24	4	vaccine	vaccine	NN
cord-341050-hnuogpqn	24	5	or	or	CC
cord-341050-hnuogpqn	24	6	antiviral	antiviral	JJ
cord-341050-hnuogpqn	24	7	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	24	8	is	be	VBZ
cord-341050-hnuogpqn	24	9	currently	currently	RB
cord-341050-hnuogpqn	24	10	available	available	JJ
cord-341050-hnuogpqn	24	11	,	,	,
cord-341050-hnuogpqn	24	12	which	which	WDT
cord-341050-hnuogpqn	24	13	limits	limit	VBZ
cord-341050-hnuogpqn	24	14	current	current	JJ
cord-341050-hnuogpqn	24	15	treatments	treatment	NNS
cord-341050-hnuogpqn	24	16	to	to	IN
cord-341050-hnuogpqn	24	17	only	only	RB
cord-341050-hnuogpqn	24	18	supportive	supportive	JJ
cord-341050-hnuogpqn	24	19	care	care	NN
cord-341050-hnuogpqn	24	20	measures	measure	NNS
cord-341050-hnuogpqn	24	21	,	,	,
cord-341050-hnuogpqn	24	22	such	such	JJ
cord-341050-hnuogpqn	24	23	as	as	IN
cord-341050-hnuogpqn	24	24	intravenous	intravenous	JJ
cord-341050-hnuogpqn	24	25	fl	fl	NNP
cord-341050-hnuogpqn	24	26	uids	uid	NNS
cord-341050-hnuogpqn	24	27	,	,	,
cord-341050-hnuogpqn	24	28	antipyretics	antipyretic	NNS
cord-341050-hnuogpqn	24	29	,	,	,
cord-341050-hnuogpqn	24	30	respiratory	respiratory	JJ
cord-341050-hnuogpqn	24	31	support	support	NN
cord-341050-hnuogpqn	24	32	,	,	,
cord-341050-hnuogpqn	24	33	and	and	CC
cord-341050-hnuogpqn	24	34	prevention	prevention	NN
cord-341050-hnuogpqn	24	35	of	of	IN
cord-341050-hnuogpqn	24	36	secondary	secondary	JJ
cord-341050-hnuogpqn	24	37	infections	infection	NNS
cord-341050-hnuogpqn	24	38	.	.	.
cord-341050-hnuogpqn	25	1	Considering	consider	VBG
cord-341050-hnuogpqn	25	2	the	the	DT
cord-341050-hnuogpqn	25	3	worldwide	worldwide	JJ
cord-341050-hnuogpqn	25	4	distribution	distribution	NN
cord-341050-hnuogpqn	25	5	of	of	IN
cord-341050-hnuogpqn	25	6	this	this	DT
cord-341050-hnuogpqn	25	7	virus	virus	NN
cord-341050-hnuogpqn	25	8	and	and	CC
cord-341050-hnuogpqn	25	9	evidence	evidence	NN
cord-341050-hnuogpqn	25	10	of	of	IN
cord-341050-hnuogpqn	25	11	its	-PRON-	PRP$
cord-341050-hnuogpqn	25	12	potential	potential	NN
cord-341050-hnuogpqn	25	13	to	to	TO
cord-341050-hnuogpqn	25	14	change	change	VB
cord-341050-hnuogpqn	25	15	in	in	IN
cord-341050-hnuogpqn	25	16	pathogenicity	pathogenicity	NN
cord-341050-hnuogpqn	25	17	and	and	CC
cord-341050-hnuogpqn	25	18	transmission	transmission	NN
cord-341050-hnuogpqn	25	19	[	[	-LRB-
cord-341050-hnuogpqn	25	20	26	26	CD
cord-341050-hnuogpqn	25	21	-30	-30	CD
cord-341050-hnuogpqn	25	22	]	]	-RRB-
cord-341050-hnuogpqn	25	23	,	,	,
cord-341050-hnuogpqn	25	24	there	there	EX
cord-341050-hnuogpqn	25	25	is	be	VBZ
cord-341050-hnuogpqn	25	26	an	an	DT
cord-341050-hnuogpqn	25	27	urgent	urgent	JJ
cord-341050-hnuogpqn	25	28	need	need	NN
cord-341050-hnuogpqn	25	29	to	to	TO
cord-341050-hnuogpqn	25	30	develop	develop	VB
cord-341050-hnuogpqn	25	31	safe	safe	JJ
cord-341050-hnuogpqn	25	32	and	and	CC
cord-341050-hnuogpqn	25	33	effective	effective	JJ
cord-341050-hnuogpqn	25	34	antiviral	antiviral	JJ
cord-341050-hnuogpqn	25	35	drugs	drug	NNS
cord-341050-hnuogpqn	25	36	or	or	CC
cord-341050-hnuogpqn	25	37	vaccines	vaccine	NNS
cord-341050-hnuogpqn	25	38	against	against	IN
cord-341050-hnuogpqn	25	39	WNV	WNV	NNP
cord-341050-hnuogpqn	25	40	infection	infection	NN
cord-341050-hnuogpqn	25	41	[	[	-LRB-
cord-341050-hnuogpqn	25	42	31	31	CD
cord-341050-hnuogpqn	25	43	]	]	-RRB-
cord-341050-hnuogpqn	25	44	.	.	.
cord-341050-hnuogpqn	26	1	Intensive	intensive	JJ
cord-341050-hnuogpqn	26	2	research	research	NN
cord-341050-hnuogpqn	26	3	during	during	IN
cord-341050-hnuogpqn	26	4	past	past	JJ
cord-341050-hnuogpqn	26	5	decades	decade	NNS
cord-341050-hnuogpqn	26	6	has	have	VBZ
cord-341050-hnuogpqn	26	7	made	make	VBN
cord-341050-hnuogpqn	26	8	signifi	signifi	NNP
cord-341050-hnuogpqn	26	9	ca	can	MD
cord-341050-hnuogpqn	26	10	nt	not	RB
cord-341050-hnuogpqn	26	11	progress	progress	VB
cord-341050-hnuogpqn	26	12	in	in	IN
cord-341050-hnuogpqn	26	13	the	the	DT
cord-341050-hnuogpqn	26	14	design	design	NN
cord-341050-hnuogpqn	26	15	and	and	CC
cord-341050-hnuogpqn	26	16	development	development	NN
cord-341050-hnuogpqn	26	17	of	of	IN
cord-341050-hnuogpqn	26	18	several	several	JJ
cord-341050-hnuogpqn	26	19	treatment	treatment	NN
cord-341050-hnuogpqn	26	20	and	and	CC
cord-341050-hnuogpqn	26	21	prevention	prevention	NN
cord-341050-hnuogpqn	26	22	methods	method	NNS
cord-341050-hnuogpqn	26	23	for	for	IN
cord-341050-hnuogpqn	26	24	WNV	WNV	NNP
cord-341050-hnuogpqn	26	25	infection	infection	NN
cord-341050-hnuogpqn	26	26	(	(	-LRB-
cord-341050-hnuogpqn	26	27	reviewed	review	VBN
cord-341050-hnuogpqn	26	28	by	by	IN
cord-341050-hnuogpqn	26	29	[	[	-LRB-
cord-341050-hnuogpqn	26	30	32	32	CD
cord-341050-hnuogpqn	26	31	-34	-34	CD
cord-341050-hnuogpqn	26	32	]	]	-RRB-
cord-341050-hnuogpqn	26	33	)	)	-RRB-
cord-341050-hnuogpqn	26	34	.	.	.
cord-341050-hnuogpqn	27	1	Here	here	RB
cord-341050-hnuogpqn	27	2	,	,	,
cord-341050-hnuogpqn	27	3	we	-PRON-	PRP
cord-341050-hnuogpqn	27	4	discuss	discuss	VBP
cord-341050-hnuogpqn	27	5	the	the	DT
cord-341050-hnuogpqn	27	6	current	current	JJ
cord-341050-hnuogpqn	27	7	approaches	approach	NNS
cord-341050-hnuogpqn	27	8	and	and	CC
cord-341050-hnuogpqn	27	9	recent	recent	JJ
cord-341050-hnuogpqn	27	10	progress	progress	NN
cord-341050-hnuogpqn	27	11	toward	toward	IN
cord-341050-hnuogpqn	27	12	the	the	DT
cord-341050-hnuogpqn	27	13	development	development	NN
cord-341050-hnuogpqn	27	14	of	of	IN
cord-341050-hnuogpqn	27	15	vaccines	vaccine	NNS
cord-341050-hnuogpqn	27	16	,	,	,
cord-341050-hnuogpqn	27	17	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	27	18	antibodies	antibody	NNS
cord-341050-hnuogpqn	27	19	,	,	,
cord-341050-hnuogpqn	27	20	and	and	CC
cord-341050-hnuogpqn	27	21	antiviral	antiviral	JJ
cord-341050-hnuogpqn	27	22	drugs	drug	NNS
cord-341050-hnuogpqn	27	23	against	against	IN
cord-341050-hnuogpqn	27	24	WNV	WNV	NNP
cord-341050-hnuogpqn	27	25	infection	infection	NN
cord-341050-hnuogpqn	27	26	in	in	IN
cord-341050-hnuogpqn	27	27	humans	human	NNS
cord-341050-hnuogpqn	27	28	.	.	.
cord-341050-hnuogpqn	28	1	WNV	WNV	NNP
cord-341050-hnuogpqn	28	2	is	be	VBZ
cord-341050-hnuogpqn	28	3	a	a	DT
cord-341050-hnuogpqn	28	4	spherical	spherical	JJ
cord-341050-hnuogpqn	28	5	virus	virus	NN
cord-341050-hnuogpqn	28	6	with	with	IN
cord-341050-hnuogpqn	28	7	50	50	CD
cord-341050-hnuogpqn	28	8	nm	nm	NN
cord-341050-hnuogpqn	28	9	in	in	IN
cord-341050-hnuogpqn	28	10	diameter	diameter	NN
cord-341050-hnuogpqn	28	11	,	,	,
cord-341050-hnuogpqn	28	12	which	which	WDT
cord-341050-hnuogpqn	28	13	comprises	comprise	VBZ
cord-341050-hnuogpqn	28	14	an	an	DT
cord-341050-hnuogpqn	28	15	icosahedral	icosahedral	JJ
cord-341050-hnuogpqn	28	16	nucleocapsid	nucleocapsid	NN
cord-341050-hnuogpqn	28	17	surrounded	surround	VBN
cord-341050-hnuogpqn	28	18	by	by	IN
cord-341050-hnuogpqn	28	19	a	a	DT
cord-341050-hnuogpqn	28	20	lipid	lipid	NN
cord-341050-hnuogpqn	28	21	envelope	envelope	NN
cord-341050-hnuogpqn	28	22	[	[	-LRB-
cord-341050-hnuogpqn	28	23	35	35	CD
cord-341050-hnuogpqn	28	24	]	]	-RRB-
cord-341050-hnuogpqn	28	25	.	.	.
cord-341050-hnuogpqn	29	1	The	the	DT
cord-341050-hnuogpqn	29	2	virus	virus	NN
cord-341050-hnuogpqn	29	3	contains	contain	VBZ
cord-341050-hnuogpqn	29	4	a	a	DT
cord-341050-hnuogpqn	29	5	single	single	JJ
cord-341050-hnuogpqn	29	6	-	-	HYPH
cord-341050-hnuogpqn	29	7	stranded	stranded	JJ
cord-341050-hnuogpqn	29	8	,	,	,
cord-341050-hnuogpqn	29	9	capped	cap	VBN
cord-341050-hnuogpqn	29	10	,	,	,
cord-341050-hnuogpqn	29	11	and	and	CC
cord-341050-hnuogpqn	29	12	plus	plus	RB
cord-341050-hnuogpqn	29	13	-	-	HYPH
cord-341050-hnuogpqn	29	14	sensed	sense	VBN
cord-341050-hnuogpqn	29	15	RNA	RNA	NNP
cord-341050-hnuogpqn	29	16	genome	genome	NN
cord-341050-hnuogpqn	29	17	of	of	IN
cord-341050-hnuogpqn	29	18	approximately	approximately	RB
cord-341050-hnuogpqn	29	19	11	11	CD
cord-341050-hnuogpqn	29	20	kb	kb	NNS
cord-341050-hnuogpqn	29	21	in	in	IN
cord-341050-hnuogpqn	29	22	size	size	NN
cord-341050-hnuogpqn	29	23	.	.	.
cord-341050-hnuogpqn	30	1	The	the	DT
cord-341050-hnuogpqn	30	2	viral	viral	JJ
cord-341050-hnuogpqn	30	3	genome	genome	NN
cord-341050-hnuogpqn	30	4	encodes	encode	VBZ
cord-341050-hnuogpqn	30	5	a	a	DT
cord-341050-hnuogpqn	30	6	polyprotein	polyprotein	JJ
cord-341050-hnuogpqn	30	7	precursor	precursor	NN
cord-341050-hnuogpqn	30	8	,	,	,
cord-341050-hnuogpqn	30	9	which	which	WDT
cord-341050-hnuogpqn	30	10	undergoes	undergo	VBZ
cord-341050-hnuogpqn	30	11	posttranslational	posttranslational	JJ
cord-341050-hnuogpqn	30	12	processing	processing	NN
cord-341050-hnuogpqn	30	13	by	by	IN
cord-341050-hnuogpqn	30	14	cellular	cellular	JJ
cord-341050-hnuogpqn	30	15	and	and	CC
cord-341050-hnuogpqn	30	16	viral	viral	JJ
cord-341050-hnuogpqn	30	17	proteases	protease	NNS
cord-341050-hnuogpqn	30	18	to	to	TO
cord-341050-hnuogpqn	30	19	generate	generate	VB
cord-341050-hnuogpqn	30	20	three	three	CD
cord-341050-hnuogpqn	30	21	structural	structural	JJ
cord-341050-hnuogpqn	30	22	proteins	protein	NNS
cord-341050-hnuogpqn	30	23	(	(	-LRB-
cord-341050-hnuogpqn	30	24	capsid	capsid	JJ
cord-341050-hnuogpqn	30	25	[	[	-LRB-
cord-341050-hnuogpqn	30	26	C	C	NNP
cord-341050-hnuogpqn	30	27	]	]	-RRB-
cord-341050-hnuogpqn	30	28	,	,	,
cord-341050-hnuogpqn	30	29	premembrane	premembrane	NNP
cord-341050-hnuogpqn	30	30	[	[	-LRB-
cord-341050-hnuogpqn	30	31	PrM	prm	NN
cord-341050-hnuogpqn	30	32	]	]	-RRB-
cord-341050-hnuogpqn	30	33	,	,	,
cord-341050-hnuogpqn	30	34	and	and	CC
cord-341050-hnuogpqn	30	35	envelope	envelope	NN
cord-341050-hnuogpqn	30	36	[	[	-LRB-
cord-341050-hnuogpqn	30	37	E	e	NN
cord-341050-hnuogpqn	30	38	]	]	-RRB-
cord-341050-hnuogpqn	30	39	)	)	-RRB-
cord-341050-hnuogpqn	30	40	,	,	,
cord-341050-hnuogpqn	30	41	and	and	CC
cord-341050-hnuogpqn	30	42	seven	seven	CD
cord-341050-hnuogpqn	30	43	non	non	JJ
cord-341050-hnuogpqn	30	44	-	-	JJ
cord-341050-hnuogpqn	30	45	structural	structural	JJ
cord-341050-hnuogpqn	30	46	proteins	protein	NNS
cord-341050-hnuogpqn	30	47	(	(	-LRB-
cord-341050-hnuogpqn	30	48	NS1	ns1	UH
cord-341050-hnuogpqn	30	49	,	,	,
cord-341050-hnuogpqn	30	50	NS2A	ns2a	UH
cord-341050-hnuogpqn	30	51	,	,	,
cord-341050-hnuogpqn	30	52	NS2B	NS2B	NNP
cord-341050-hnuogpqn	30	53	,	,	,
cord-341050-hnuogpqn	30	54	NS3	ns3	RB
cord-341050-hnuogpqn	30	55	,	,	,
cord-341050-hnuogpqn	30	56	NS4A	NS4A	NNP
cord-341050-hnuogpqn	30	57	,	,	,
cord-341050-hnuogpqn	30	58	NS4B	NS4B	NNP
cord-341050-hnuogpqn	30	59	,	,	,
cord-341050-hnuogpqn	30	60	and	and	CC
cord-341050-hnuogpqn	30	61	NS5	NS5	NNP
cord-341050-hnuogpqn	30	62	)	)	-RRB-
cord-341050-hnuogpqn	30	63	.	.	.
cord-341050-hnuogpqn	31	1	The	the	DT
cord-341050-hnuogpqn	31	2	structural	structural	JJ
cord-341050-hnuogpqn	31	3	proteins	protein	NNS
cord-341050-hnuogpqn	31	4	form	form	VBP
cord-341050-hnuogpqn	31	5	virion	virion	NN
cord-341050-hnuogpqn	31	6	structure	structure	NN
cord-341050-hnuogpqn	31	7	,	,	,
cord-341050-hnuogpqn	31	8	whereas	whereas	IN
cord-341050-hnuogpqn	31	9	the	the	DT
cord-341050-hnuogpqn	31	10	non	non	JJ
cord-341050-hnuogpqn	31	11	-	-	JJ
cord-341050-hnuogpqn	31	12	structural	structural	JJ
cord-341050-hnuogpqn	31	13	proteins	protein	NNS
cord-341050-hnuogpqn	31	14	play	play	VBP
cord-341050-hnuogpqn	31	15	essential	essential	JJ
cord-341050-hnuogpqn	31	16	roles	role	NNS
cord-341050-hnuogpqn	31	17	in	in	IN
cord-341050-hnuogpqn	31	18	the	the	DT
cord-341050-hnuogpqn	31	19	replication	replication	NN
cord-341050-hnuogpqn	31	20	of	of	IN
cord-341050-hnuogpqn	31	21	viral	viral	JJ
cord-341050-hnuogpqn	31	22	genome	genome	NN
cord-341050-hnuogpqn	31	23	,	,	,
cord-341050-hnuogpqn	31	24	assembly	assembly	NN
cord-341050-hnuogpqn	31	25	of	of	IN
cord-341050-hnuogpqn	31	26	virion	virion	NN
cord-341050-hnuogpqn	31	27	,	,	,
cord-341050-hnuogpqn	31	28	and	and	CC
cord-341050-hnuogpqn	31	29	viral	viral	JJ
cord-341050-hnuogpqn	31	30	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	31	31	[	[	-LRB-
cord-341050-hnuogpqn	31	32	36	36	CD
cord-341050-hnuogpqn	31	33	-38	-38	CD
cord-341050-hnuogpqn	31	34	]	]	-RRB-
cord-341050-hnuogpqn	31	35	.	.	.
cord-341050-hnuogpqn	32	1	Thus	thus	RB
cord-341050-hnuogpqn	32	2	,	,	,
cord-341050-hnuogpqn	32	3	the	the	DT
cord-341050-hnuogpqn	32	4	structural	structural	JJ
cord-341050-hnuogpqn	32	5	and	and	CC
cord-341050-hnuogpqn	32	6	non	non	JJ
cord-341050-hnuogpqn	32	7	-	-	JJ
cord-341050-hnuogpqn	32	8	structural	structural	JJ
cord-341050-hnuogpqn	32	9	proteins	protein	NNS
cord-341050-hnuogpqn	32	10	of	of	IN
cord-341050-hnuogpqn	32	11	WNV	WNV	NNP
cord-341050-hnuogpqn	32	12	may	may	MD
cord-341050-hnuogpqn	32	13	be	be	VB
cord-341050-hnuogpqn	32	14	potential	potential	JJ
cord-341050-hnuogpqn	32	15	targets	target	NNS
cord-341050-hnuogpqn	32	16	for	for	IN
cord-341050-hnuogpqn	32	17	developing	develop	VBG
cord-341050-hnuogpqn	32	18	vaccines	vaccine	NNS
cord-341050-hnuogpqn	32	19	and	and	CC
cord-341050-hnuogpqn	32	20	antiviral	antiviral	JJ
cord-341050-hnuogpqn	32	21	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	32	22	(	(	-LRB-
cord-341050-hnuogpqn	32	23	Table	Table	NNP
cord-341050-hnuogpqn	32	24	1	1	CD
cord-341050-hnuogpqn	32	25	)	)	-RRB-
cord-341050-hnuogpqn	32	26	.	.	.
cord-341050-hnuogpqn	33	1	In	in	IN
cord-341050-hnuogpqn	33	2	a	a	DT
cord-341050-hnuogpqn	33	3	WNV	WNV	NNP
cord-341050-hnuogpqn	33	4	virion	virion	NN
cord-341050-hnuogpqn	33	5	structure	structure	NN
cord-341050-hnuogpqn	33	6	,	,	,
cord-341050-hnuogpqn	33	7	C	C	NNP
cord-341050-hnuogpqn	33	8	protein	protein	NN
cord-341050-hnuogpqn	33	9	encapsulates	encapsulate	VBZ
cord-341050-hnuogpqn	33	10	viral	viral	JJ
cord-341050-hnuogpqn	33	11	genomic	genomic	JJ
cord-341050-hnuogpqn	33	12	RNA	RNA	NNP
cord-341050-hnuogpqn	33	13	to	to	TO
cord-341050-hnuogpqn	33	14	form	form	VB
cord-341050-hnuogpqn	33	15	a	a	DT
cord-341050-hnuogpqn	33	16	nucleocapsid	nucleocapsid	NN
cord-341050-hnuogpqn	33	17	that	that	WDT
cord-341050-hnuogpqn	33	18	is	be	VBZ
cord-341050-hnuogpqn	33	19	enveloped	envelop	VBN
cord-341050-hnuogpqn	33	20	by	by	IN
cord-341050-hnuogpqn	33	21	a	a	DT
cord-341050-hnuogpqn	33	22	lipid	lipid	NN
cord-341050-hnuogpqn	33	23	bilayer	bilayer	NN
cord-341050-hnuogpqn	33	24	into	into	IN
cord-341050-hnuogpqn	33	25	which	which	WDT
cord-341050-hnuogpqn	33	26	trimmers	trimmer	NNS
cord-341050-hnuogpqn	33	27	of	of	IN
cord-341050-hnuogpqn	33	28	prM	prm	JJ
cord-341050-hnuogpqn	33	29	-	-	HYPH
cord-341050-hnuogpqn	33	30	E	e	NN
cord-341050-hnuogpqn	33	31	heterodimers	heterodimer	NNS
cord-341050-hnuogpqn	33	32	form	form	VB
cord-341050-hnuogpqn	33	33	the	the	DT
cord-341050-hnuogpqn	33	34	spikelike	spikelike	NN
cord-341050-hnuogpqn	33	35	projections	projection	NNS
cord-341050-hnuogpqn	33	36	.	.	.
cord-341050-hnuogpqn	34	1	Among	among	IN
cord-341050-hnuogpqn	34	2	these	these	DT
cord-341050-hnuogpqn	34	3	structural	structural	JJ
cord-341050-hnuogpqn	34	4	proteins	protein	NNS
cord-341050-hnuogpqn	34	5	,	,	,
cord-341050-hnuogpqn	34	6	E	e	NN
cord-341050-hnuogpqn	34	7	protein	protein	NN
cord-341050-hnuogpqn	34	8	mediates	mediate	VBZ
cord-341050-hnuogpqn	34	9	crucial	crucial	JJ
cord-341050-hnuogpqn	34	10	roles	role	NNS
cord-341050-hnuogpqn	34	11	in	in	IN
cord-341050-hnuogpqn	34	12	binding	bind	VBG
cord-341050-hnuogpqn	34	13	to	to	IN
cord-341050-hnuogpqn	34	14	cellular	cellular	JJ
cord-341050-hnuogpqn	34	15	receptors	receptor	NNS
cord-341050-hnuogpqn	34	16	,	,	,
cord-341050-hnuogpqn	34	17	membrane	membrane	NN
cord-341050-hnuogpqn	34	18	fusion	fusion	NN
cord-341050-hnuogpqn	34	19	,	,	,
cord-341050-hnuogpqn	34	20	and	and	CC
cord-341050-hnuogpqn	34	21	entry	entry	NN
cord-341050-hnuogpqn	34	22	of	of	IN
cord-341050-hnuogpqn	34	23	WNV	WNV	NNP
cord-341050-hnuogpqn	34	24	into	into	IN
cord-341050-hnuogpqn	34	25	host	host	NN
cord-341050-hnuogpqn	34	26	cells	cell	NNS
cord-341050-hnuogpqn	34	27	,	,	,
cord-341050-hnuogpqn	34	28	making	make	VBG
cord-341050-hnuogpqn	34	29	it	-PRON-	PRP
cord-341050-hnuogpqn	34	30	a	a	DT
cord-341050-hnuogpqn	34	31	key	key	JJ
cord-341050-hnuogpqn	34	32	target	target	NN
cord-341050-hnuogpqn	34	33	for	for	IN
cord-341050-hnuogpqn	34	34	the	the	DT
cord-341050-hnuogpqn	34	35	development	development	NN
cord-341050-hnuogpqn	34	36	of	of	IN
cord-341050-hnuogpqn	34	37	vaccines	vaccine	NNS
cord-341050-hnuogpqn	34	38	,	,	,
cord-341050-hnuogpqn	34	39	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	34	40	antibodies	antibody	NNS
cord-341050-hnuogpqn	34	41	,	,	,
cord-341050-hnuogpqn	34	42	and	and	CC
cord-341050-hnuogpqn	34	43	entry	entry	NN
cord-341050-hnuogpqn	34	44	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	34	45	.	.	.
cord-341050-hnuogpqn	35	1	Crystal	crystal	NN
cord-341050-hnuogpqn	35	2	structure	structure	NN
cord-341050-hnuogpqn	35	3	analysis	analysis	NN
cord-341050-hnuogpqn	35	4	has	have	VBZ
cord-341050-hnuogpqn	35	5	confi	confi	VBN
cord-341050-hnuogpqn	35	6	rmed	rmed	NNP
cord-341050-hnuogpqn	35	7	that	that	WDT
cord-341050-hnuogpqn	35	8	E	e	NN
cord-341050-hnuogpqn	35	9	protein	protein	NN
cord-341050-hnuogpqn	35	10	folds	fold	VBZ
cord-341050-hnuogpqn	35	11	into	into	IN
cord-341050-hnuogpqn	35	12	three	three	CD
cord-341050-hnuogpqn	35	13	structurally	structurally	RB
cord-341050-hnuogpqn	35	14	distinct	distinct	JJ
cord-341050-hnuogpqn	35	15	ectodomains	ectodomain	NNS
cord-341050-hnuogpqn	35	16	(	(	-LRB-
cord-341050-hnuogpqn	35	17	EDs	EDs	NNP
cord-341050-hnuogpqn	35	18	)	)	-RRB-
cord-341050-hnuogpqn	35	19	termed	term	VBD
cord-341050-hnuogpqn	35	20	EDI	EDI	NNP
cord-341050-hnuogpqn	35	21	,	,	,
cord-341050-hnuogpqn	35	22	EDII	EDII	NNP
cord-341050-hnuogpqn	35	23	and	and	CC
cord-341050-hnuogpqn	35	24	EDIII	EDIII	NNP
cord-341050-hnuogpqn	35	25	[	[	-LRB-
cord-341050-hnuogpqn	35	26	39	39	CD
cord-341050-hnuogpqn	35	27	-43	-43	NN
cord-341050-hnuogpqn	35	28	]	]	-RRB-
cord-341050-hnuogpqn	35	29	.	.	.
cord-341050-hnuogpqn	36	1	Among	among	IN
cord-341050-hnuogpqn	36	2	these	these	DT
cord-341050-hnuogpqn	36	3	,	,	,
cord-341050-hnuogpqn	36	4	the	the	DT
cord-341050-hnuogpqn	36	5	EDIII	EDIII	NNP
cord-341050-hnuogpqn	36	6	consists	consist	VBZ
cord-341050-hnuogpqn	36	7	of	of	IN
cord-341050-hnuogpqn	36	8	the	the	DT
cord-341050-hnuogpqn	36	9	major	major	JJ
cord-341050-hnuogpqn	36	10	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	36	11	epitopes	epitope	NNS
cord-341050-hnuogpqn	36	12	and	and	CC
cord-341050-hnuogpqn	36	13	is	be	VBZ
cord-341050-hnuogpqn	36	14	an	an	DT
cord-341050-hnuogpqn	36	15	antigen	antigen	NN
cord-341050-hnuogpqn	36	16	of	of	IN
cord-341050-hnuogpqn	36	17	choice	choice	NN
cord-341050-hnuogpqn	36	18	to	to	TO
cord-341050-hnuogpqn	36	19	elicit	elicit	VB
cord-341050-hnuogpqn	36	20	production	production	NN
cord-341050-hnuogpqn	36	21	of	of	IN
cord-341050-hnuogpqn	36	22	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	36	23	antibodies	antibody	NNS
cord-341050-hnuogpqn	36	24	[	[	-LRB-
cord-341050-hnuogpqn	36	25	43	43	CD
cord-341050-hnuogpqn	36	26	-46	-46	NN
cord-341050-hnuogpqn	36	27	]	]	-RRB-
cord-341050-hnuogpqn	36	28	.	.	.
cord-341050-hnuogpqn	37	1	Based	base	VBN
cord-341050-hnuogpqn	37	2	on	on	IN
cord-341050-hnuogpqn	37	3	the	the	DT
cord-341050-hnuogpqn	37	4	structural	structural	JJ
cord-341050-hnuogpqn	37	5	characterization	characterization	NN
cord-341050-hnuogpqn	37	6	of	of	IN
cord-341050-hnuogpqn	37	7	antifl	antifl	NN
cord-341050-hnuogpqn	37	8	aviviral	aviviral	NNP
cord-341050-hnuogpqn	37	9	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	37	10	antibodies	antibody	NNS
cord-341050-hnuogpqn	37	11	from	from	IN
cord-341050-hnuogpqn	37	12	both	both	CC
cord-341050-hnuogpqn	37	13	human	human	JJ
cord-341050-hnuogpqn	37	14	and	and	CC
cord-341050-hnuogpqn	37	15	nonhuman	nonhuman	NN
cord-341050-hnuogpqn	37	16	primate	primate	NN
cord-341050-hnuogpqn	37	17	,	,	,
cord-341050-hnuogpqn	37	18	it	-PRON-	PRP
cord-341050-hnuogpqn	37	19	appears	appear	VBZ
cord-341050-hnuogpqn	37	20	that	that	IN
cord-341050-hnuogpqn	37	21	the	the	DT
cord-341050-hnuogpqn	37	22	epitopes	epitope	NNS
cord-341050-hnuogpqn	37	23	of	of	IN
cord-341050-hnuogpqn	37	24	fl	fl	NNP
cord-341050-hnuogpqn	37	25	aviviral	aviviral	NNP
cord-341050-hnuogpqn	37	26	E	E	NNP
cord-341050-hnuogpqn	37	27	protein	protein	NN
cord-341050-hnuogpqn	37	28	are	be	VBP
cord-341050-hnuogpqn	37	29	more	more	RBR
cord-341050-hnuogpqn	37	30	complex	complex	JJ
cord-341050-hnuogpqn	37	31	and	and	CC
cord-341050-hnuogpqn	37	32	diverse	diverse	JJ
cord-341050-hnuogpqn	37	33	than	than	IN
cord-341050-hnuogpqn	37	34	previously	previously	RB
cord-341050-hnuogpqn	37	35	thought	think	VBN
cord-341050-hnuogpqn	37	36	[	[	-LRB-
cord-341050-hnuogpqn	37	37	47	47	CD
cord-341050-hnuogpqn	37	38	-50	-50	NN
cord-341050-hnuogpqn	37	39	]	]	-RRB-
cord-341050-hnuogpqn	37	40	.	.	.
cord-341050-hnuogpqn	38	1	In	in	IN
cord-341050-hnuogpqn	38	2	addition	addition	NN
cord-341050-hnuogpqn	38	3	,	,	,
cord-341050-hnuogpqn	38	4	mapping	mapping	NN
cord-341050-hnuogpqn	38	5	of	of	IN
cord-341050-hnuogpqn	38	6	B	b	NN
cord-341050-hnuogpqn	38	7	-	-	HYPH
cord-341050-hnuogpqn	38	8	cell	cell	NN
cord-341050-hnuogpqn	38	9	and	and	CC
cord-341050-hnuogpqn	38	10	T	t	NN
cord-341050-hnuogpqn	38	11	-	-	HYPH
cord-341050-hnuogpqn	38	12	cell	cell	NN
cord-341050-hnuogpqn	38	13	epitopes	epitope	NNS
cord-341050-hnuogpqn	38	14	has	have	VBZ
cord-341050-hnuogpqn	38	15	led	lead	VBN
cord-341050-hnuogpqn	38	16	to	to	IN
cord-341050-hnuogpqn	38	17	the	the	DT
cord-341050-hnuogpqn	38	18	identifi	identifi	NNP
cord-341050-hnuogpqn	38	19	cation	cation	NN
cord-341050-hnuogpqn	38	20	of	of	IN
cord-341050-hnuogpqn	38	21	many	many	JJ
cord-341050-hnuogpqn	38	22	immunodominant	immunodominant	JJ
cord-341050-hnuogpqn	38	23	epitopes	epitope	NNS
cord-341050-hnuogpqn	38	24	in	in	IN
cord-341050-hnuogpqn	38	25	both	both	DT
cord-341050-hnuogpqn	38	26	structural	structural	JJ
cord-341050-hnuogpqn	38	27	and	and	CC
cord-341050-hnuogpqn	38	28	nonstructural	nonstructural	JJ
cord-341050-hnuogpqn	38	29	proteins	protein	NNS
cord-341050-hnuogpqn	38	30	of	of	IN
cord-341050-hnuogpqn	38	31	WNV	WNV	NNP
cord-341050-hnuogpqn	38	32	[	[	-LRB-
cord-341050-hnuogpqn	38	33	51	51	CD
cord-341050-hnuogpqn	38	34	,	,	,
cord-341050-hnuogpqn	38	35	52	52	CD
cord-341050-hnuogpqn	38	36	]	]	-RRB-
cord-341050-hnuogpqn	38	37	.	.	.
cord-341050-hnuogpqn	39	1	Among	among	IN
cord-341050-hnuogpqn	39	2	the	the	DT
cord-341050-hnuogpqn	39	3	non	non	JJ
cord-341050-hnuogpqn	39	4	-	-	JJ
cord-341050-hnuogpqn	39	5	structural	structural	JJ
cord-341050-hnuogpqn	39	6	proteins	protein	NNS
cord-341050-hnuogpqn	39	7	,	,	,
cord-341050-hnuogpqn	39	8	NS3	ns3	RB
cord-341050-hnuogpqn	39	9	and	and	CC
cord-341050-hnuogpqn	39	10	NS5	NS5	NNP
cord-341050-hnuogpqn	39	11	are	be	VBP
cord-341050-hnuogpqn	39	12	bestcharacterized	bestcharacterize	VBN
cord-341050-hnuogpqn	39	13	,	,	,
cord-341050-hnuogpqn	39	14	multifunctional	multifunctional	JJ
cord-341050-hnuogpqn	39	15	proteins	protein	NNS
cord-341050-hnuogpqn	39	16	,	,	,
cord-341050-hnuogpqn	39	17	both	both	DT
cord-341050-hnuogpqn	39	18	of	of	IN
cord-341050-hnuogpqn	39	19	which	which	WDT
cord-341050-hnuogpqn	39	20	contain	contain	VBP
cord-341050-hnuogpqn	39	21	enzymatic	enzymatic	JJ
cord-341050-hnuogpqn	39	22	activities	activity	NNS
cord-341050-hnuogpqn	39	23	that	that	WDT
cord-341050-hnuogpqn	39	24	are	be	VBP
cord-341050-hnuogpqn	39	25	essential	essential	JJ
cord-341050-hnuogpqn	39	26	for	for	IN
cord-341050-hnuogpqn	39	27	viral	viral	JJ
cord-341050-hnuogpqn	39	28	replication	replication	NN
cord-341050-hnuogpqn	39	29	[	[	-LRB-
cord-341050-hnuogpqn	39	30	53	53	CD
cord-341050-hnuogpqn	39	31	-55	-55	NNP
cord-341050-hnuogpqn	39	32	]	]	-RRB-
cord-341050-hnuogpqn	39	33	.	.	.
cord-341050-hnuogpqn	40	1	Such	such	JJ
cord-341050-hnuogpqn	40	2	enzymatic	enzymatic	JJ
cord-341050-hnuogpqn	40	3	functions	function	NNS
cord-341050-hnuogpqn	40	4	of	of	IN
cord-341050-hnuogpqn	40	5	NS3	ns3	RB
cord-341050-hnuogpqn	40	6	and	and	CC
cord-341050-hnuogpqn	40	7	NS5	ns5	JJ
cord-341050-hnuogpqn	40	8	have	have	VBP
cord-341050-hnuogpqn	40	9	received	receive	VBN
cord-341050-hnuogpqn	40	10	considerable	considerable	JJ
cord-341050-hnuogpqn	40	11	attention	attention	NN
cord-341050-hnuogpqn	40	12	as	as	IN
cord-341050-hnuogpqn	40	13	potential	potential	JJ
cord-341050-hnuogpqn	40	14	targets	target	NNS
cord-341050-hnuogpqn	40	15	for	for	IN
cord-341050-hnuogpqn	40	16	antiviral	antiviral	JJ
cord-341050-hnuogpqn	40	17	drug	drug	NN
cord-341050-hnuogpqn	40	18	development	development	NN
cord-341050-hnuogpqn	40	19	[	[	-LRB-
cord-341050-hnuogpqn	40	20	34	34	CD
cord-341050-hnuogpqn	40	21	,	,	,
cord-341050-hnuogpqn	40	22	54	54	CD
cord-341050-hnuogpqn	40	23	]	]	-RRB-
cord-341050-hnuogpqn	40	24	.	.	.
cord-341050-hnuogpqn	41	1	The	the	DT
cord-341050-hnuogpqn	41	2	NS3	ns3	RB
cord-341050-hnuogpqn	41	3	protein	protein	NN
cord-341050-hnuogpqn	41	4	contains	contain	VBZ
cord-341050-hnuogpqn	41	5	two	two	CD
cord-341050-hnuogpqn	41	6	distinct	distinct	JJ
cord-341050-hnuogpqn	41	7	functional	functional	JJ
cord-341050-hnuogpqn	41	8	domains	domain	NNS
cord-341050-hnuogpqn	41	9	.	.	.
cord-341050-hnuogpqn	42	1	The	the	DT
cord-341050-hnuogpqn	42	2	N	n	CD
cord-341050-hnuogpqn	42	3	-	-	HYPH
cord-341050-hnuogpqn	42	4	terminal	terminal	NN
cord-341050-hnuogpqn	42	5	domain	domain	NN
cord-341050-hnuogpqn	42	6	of	of	IN
cord-341050-hnuogpqn	42	7	NS3	ns3	NN
cord-341050-hnuogpqn	42	8	(	(	-LRB-
cord-341050-hnuogpqn	42	9	184	184	CD
cord-341050-hnuogpqn	42	10	amino	amino	NN
cord-341050-hnuogpqn	42	11	acid	acid	NN
cord-341050-hnuogpqn	42	12	residues	residue	NNS
cord-341050-hnuogpqn	42	13	)	)	-RRB-
cord-341050-hnuogpqn	42	14	has	have	VBZ
cord-341050-hnuogpqn	42	15	serine	serine	JJ
cord-341050-hnuogpqn	42	16	protease	protease	NN
cord-341050-hnuogpqn	42	17	activity	activity	NN
cord-341050-hnuogpqn	42	18	that	that	WDT
cord-341050-hnuogpqn	42	19	requires	require	VBZ
cord-341050-hnuogpqn	42	20	a	a	DT
cord-341050-hnuogpqn	42	21	polypeptide	polypeptide	NN
cord-341050-hnuogpqn	42	22	cofactor	cofactor	NN
cord-341050-hnuogpqn	42	23	NS2B	NS2B	NNP
cord-341050-hnuogpqn	42	24	for	for	IN
cord-341050-hnuogpqn	42	25	activation	activation	NN
cord-341050-hnuogpqn	42	26	[	[	-LRB-
cord-341050-hnuogpqn	42	27	54	54	CD
cord-341050-hnuogpqn	42	28	,	,	,
cord-341050-hnuogpqn	42	29	56	56	CD
cord-341050-hnuogpqn	42	30	,	,	,
cord-341050-hnuogpqn	42	31	57	57	CD
cord-341050-hnuogpqn	42	32	]	]	-RRB-
cord-341050-hnuogpqn	42	33	.	.	.
cord-341050-hnuogpqn	43	1	Recent	recent	JJ
cord-341050-hnuogpqn	43	2	X	x	NN
cord-341050-hnuogpqn	43	3	-	-	NN
cord-341050-hnuogpqn	43	4	ray	ray	NN
cord-341050-hnuogpqn	43	5	crystallographic	crystallographic	JJ
cord-341050-hnuogpqn	43	6	studies	study	NNS
cord-341050-hnuogpqn	43	7	have	have	VBP
cord-341050-hnuogpqn	43	8	shown	show	VBN
cord-341050-hnuogpqn	43	9	that	that	IN
cord-341050-hnuogpqn	43	10	the	the	DT
cord-341050-hnuogpqn	43	11	conformation	conformation	NN
cord-341050-hnuogpqn	43	12	of	of	IN
cord-341050-hnuogpqn	43	13	β	β	NN
cord-341050-hnuogpqn	43	14	-	-	HYPH
cord-341050-hnuogpqn	43	15	loop	loop	NN
cord-341050-hnuogpqn	43	16	of	of	IN
cord-341050-hnuogpqn	43	17	NS2B	NS2B	NNP
cord-341050-hnuogpqn	43	18	controls	control	VBZ
cord-341050-hnuogpqn	43	19	the	the	DT
cord-341050-hnuogpqn	43	20	substrate	substrate	NN
cord-341050-hnuogpqn	43	21	binding	bind	VBG
cord-341050-hnuogpqn	43	22	by	by	IN
cord-341050-hnuogpqn	43	23	NS2B	NS2B	NNP
cord-341050-hnuogpqn	43	24	/	/	SYM
cord-341050-hnuogpqn	43	25	NS3	ns3	RB
cord-341050-hnuogpqn	43	26	protease	protease	NN
cord-341050-hnuogpqn	43	27	[	[	-LRB-
cord-341050-hnuogpqn	43	28	58	58	CD
cord-341050-hnuogpqn	43	29	,	,	,
cord-341050-hnuogpqn	43	30	59	59	CD
cord-341050-hnuogpqn	43	31	]	]	-RRB-
cord-341050-hnuogpqn	43	32	.	.	.
cord-341050-hnuogpqn	44	1	In	in	IN
cord-341050-hnuogpqn	44	2	contrast	contrast	NN
cord-341050-hnuogpqn	44	3	,	,	,
cord-341050-hnuogpqn	44	4	the	the	DT
cord-341050-hnuogpqn	44	5	C	c	NN
cord-341050-hnuogpqn	44	6	-	-	HYPH
cord-341050-hnuogpqn	44	7	terminal	terminal	NN
cord-341050-hnuogpqn	44	8	domain	domain	NN
cord-341050-hnuogpqn	44	9	of	of	IN
cord-341050-hnuogpqn	44	10	NS3	NS3	NNP
cord-341050-hnuogpqn	44	11	functions	function	VBZ
cord-341050-hnuogpqn	44	12	as	as	IN
cord-341050-hnuogpqn	44	13	an	an	DT
cord-341050-hnuogpqn	44	14	RNA	RNA	NNP
cord-341050-hnuogpqn	44	15	helicase	helicase	NN
cord-341050-hnuogpqn	44	16	,	,	,
cord-341050-hnuogpqn	44	17	[	[	-LRB-
cord-341050-hnuogpqn	44	18	67	67	CD
cord-341050-hnuogpqn	44	19	]	]	-RRB-
cord-341050-hnuogpqn	44	20	.	.	.
cord-341050-hnuogpqn	45	1	Besides	besides	IN
cord-341050-hnuogpqn	45	2	its	-PRON-	PRP$
cord-341050-hnuogpqn	45	3	function	function	NN
cord-341050-hnuogpqn	45	4	in	in	IN
cord-341050-hnuogpqn	45	5	viral	viral	JJ
cord-341050-hnuogpqn	45	6	replication	replication	NN
cord-341050-hnuogpqn	45	7	,	,	,
cord-341050-hnuogpqn	45	8	NS5	NS5	NNP
cord-341050-hnuogpqn	45	9	also	also	RB
cord-341050-hnuogpqn	45	10	plays	play	VBZ
cord-341050-hnuogpqn	45	11	a	a	DT
cord-341050-hnuogpqn	45	12	role	role	NN
cord-341050-hnuogpqn	45	13	in	in	IN
cord-341050-hnuogpqn	45	14	viral	viral	JJ
cord-341050-hnuogpqn	45	15	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	45	16	by	by	IN
cord-341050-hnuogpqn	45	17	antagonizing	antagonize	VBG
cord-341050-hnuogpqn	45	18	host	host	NN
cord-341050-hnuogpqn	45	19	's	's	POS
cord-341050-hnuogpqn	45	20	interferon	interferon	NN
cord-341050-hnuogpqn	45	21	response	response	NN
cord-341050-hnuogpqn	45	22	[	[	-LRB-
cord-341050-hnuogpqn	45	23	28	28	CD
cord-341050-hnuogpqn	45	24	]	]	-RRB-
cord-341050-hnuogpqn	45	25	.	.	.
cord-341050-hnuogpqn	46	1	Other	other	JJ
cord-341050-hnuogpqn	46	2	nonstructural	nonstructural	JJ
cord-341050-hnuogpqn	46	3	proteins	protein	NNS
cord-341050-hnuogpqn	47	1	NS2A	NS2A	NNP
cord-341050-hnuogpqn	47	2	,	,	,
cord-341050-hnuogpqn	47	3	NS2B	NS2B	NNP
cord-341050-hnuogpqn	47	4	,	,	,
cord-341050-hnuogpqn	47	5	NS4A	NS4A	NNP
cord-341050-hnuogpqn	47	6	,	,	,
cord-341050-hnuogpqn	47	7	and	and	CC
cord-341050-hnuogpqn	47	8	NS4B	ns4b	DT
cord-341050-hnuogpqn	47	9	form	form	VB
cord-341050-hnuogpqn	47	10	the	the	DT
cord-341050-hnuogpqn	47	11	scaffold	scaffold	NN
cord-341050-hnuogpqn	47	12	for	for	IN
cord-341050-hnuogpqn	47	13	the	the	DT
cord-341050-hnuogpqn	47	14	viral	viral	JJ
cord-341050-hnuogpqn	47	15	replication	replication	NN
cord-341050-hnuogpqn	47	16	complex	complex	NN
cord-341050-hnuogpqn	47	17	and	and	CC
cord-341050-hnuogpqn	47	18	also	also	RB
cord-341050-hnuogpqn	47	19	have	have	VBP
cord-341050-hnuogpqn	47	20	roles	role	NNS
cord-341050-hnuogpqn	47	21	in	in	IN
cord-341050-hnuogpqn	47	22	the	the	DT
cord-341050-hnuogpqn	47	23	replication	replication	NN
cord-341050-hnuogpqn	47	24	of	of	IN
cord-341050-hnuogpqn	47	25	viral	viral	JJ
cord-341050-hnuogpqn	47	26	genome	genome	NN
cord-341050-hnuogpqn	47	27	and	and	CC
cord-341050-hnuogpqn	47	28	host	host	NN
cord-341050-hnuogpqn	47	29	immune	immune	JJ
cord-341050-hnuogpqn	47	30	evasion	evasion	NN
cord-341050-hnuogpqn	47	31	[	[	-LRB-
cord-341050-hnuogpqn	47	32	68	68	CD
cord-341050-hnuogpqn	47	33	-70	-70	NN
cord-341050-hnuogpqn	47	34	]	]	-RRB-
cord-341050-hnuogpqn	47	35	.	.	.
cord-341050-hnuogpqn	48	1	Mutations	mutation	NNS
cord-341050-hnuogpqn	48	2	in	in	IN
cord-341050-hnuogpqn	48	3	NS4B	NS4B	NNP
cord-341050-hnuogpqn	48	4	protein	protein	NN
cord-341050-hnuogpqn	48	5	may	may	MD
cord-341050-hnuogpqn	48	6	attenuate	attenuate	VB
cord-341050-hnuogpqn	48	7	WNV	WNV	NNP
cord-341050-hnuogpqn	48	8	and	and	CC
cord-341050-hnuogpqn	48	9	other	other	JJ
cord-341050-hnuogpqn	48	10	fl	fl	NNP
cord-341050-hnuogpqn	48	11	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	48	12	[	[	-LRB-
cord-341050-hnuogpqn	48	13	68	68	CD
cord-341050-hnuogpqn	48	14	,	,	,
cord-341050-hnuogpqn	48	15	69	69	CD
cord-341050-hnuogpqn	48	16	]	]	-RRB-
cord-341050-hnuogpqn	48	17	.	.	.
cord-341050-hnuogpqn	49	1	In	in	IN
cord-341050-hnuogpqn	49	2	addition	addition	NN
cord-341050-hnuogpqn	49	3	,	,	,
cord-341050-hnuogpqn	49	4	a	a	DT
cord-341050-hnuogpqn	49	5	recent	recent	JJ
cord-341050-hnuogpqn	49	6	successful	successful	JJ
cord-341050-hnuogpqn	49	7	clinical	clinical	JJ
cord-341050-hnuogpqn	49	8	trial	trial	NN
cord-341050-hnuogpqn	49	9	of	of	IN
cord-341050-hnuogpqn	49	10	a	a	DT
cord-341050-hnuogpqn	49	11	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	49	12	C	c	NN
cord-341050-hnuogpqn	49	13	virus	virus	NN
cord-341050-hnuogpqn	49	14	NS5A	NS5A	NNP
cord-341050-hnuogpqn	49	15	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	49	16	suggests	suggest	VBZ
cord-341050-hnuogpqn	49	17	that	that	IN
cord-341050-hnuogpqn	49	18	targeting	target	VBG
cord-341050-hnuogpqn	49	19	non	non	JJ
cord-341050-hnuogpqn	49	20	-	-	JJ
cord-341050-hnuogpqn	49	21	structural	structural	JJ
cord-341050-hnuogpqn	49	22	proteins	protein	NNS
cord-341050-hnuogpqn	49	23	may	may	MD
cord-341050-hnuogpqn	49	24	be	be	VB
cord-341050-hnuogpqn	49	25	an	an	DT
cord-341050-hnuogpqn	49	26	ideal	ideal	JJ
cord-341050-hnuogpqn	49	27	strategy	strategy	NN
cord-341050-hnuogpqn	49	28	to	to	TO
cord-341050-hnuogpqn	49	29	develop	develop	VB
cord-341050-hnuogpqn	49	30	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	49	31	against	against	IN
cord-341050-hnuogpqn	49	32	other	other	JJ
cord-341050-hnuogpqn	49	33	fl	fl	NNP
cord-341050-hnuogpqn	49	34	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	49	35	,	,	,
cord-341050-hnuogpqn	49	36	including	include	VBG
cord-341050-hnuogpqn	49	37	WNV	WNV	NNP
cord-341050-hnuogpqn	49	38	[	[	-LRB-
cord-341050-hnuogpqn	49	39	71	71	CD
cord-341050-hnuogpqn	49	40	]	]	-RRB-
cord-341050-hnuogpqn	49	41	.	.	.
cord-341050-hnuogpqn	50	1	74	74	CD
cord-341050-hnuogpqn	50	2	-78	-78	NN
cord-341050-hnuogpqn	50	3	]	]	-RRB-
cord-341050-hnuogpqn	50	4	.	.	.
cord-341050-hnuogpqn	51	1	In	in	IN
cord-341050-hnuogpqn	51	2	particular	particular	JJ
cord-341050-hnuogpqn	51	3	,	,	,
cord-341050-hnuogpqn	51	4	the	the	DT
cord-341050-hnuogpqn	51	5	C	c	NN
cord-341050-hnuogpqn	51	6	-	-	HYPH
cord-341050-hnuogpqn	51	7	terminal	terminal	NN
cord-341050-hnuogpqn	51	8	EDIII	EDIII	NNP
cord-341050-hnuogpqn	51	9	of	of	IN
cord-341050-hnuogpqn	51	10	E	e	NN
cord-341050-hnuogpqn	51	11	protein	protein	NN
cord-341050-hnuogpqn	51	12	that	that	WDT
cord-341050-hnuogpqn	51	13	contains	contain	VBZ
cord-341050-hnuogpqn	51	14	critical	critical	JJ
cord-341050-hnuogpqn	51	15	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	51	16	epitopes	epitope	NNS
cord-341050-hnuogpqn	51	17	is	be	VBZ
cord-341050-hnuogpqn	51	18	the	the	DT
cord-341050-hnuogpqn	51	19	major	major	JJ
cord-341050-hnuogpqn	51	20	target	target	NN
cord-341050-hnuogpqn	51	21	for	for	IN
cord-341050-hnuogpqn	51	22	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	51	23	antibodies	antibody	NNS
cord-341050-hnuogpqn	51	24	against	against	IN
cord-341050-hnuogpqn	51	25	WNV	WNV	NNP
cord-341050-hnuogpqn	51	26	infection	infection	NN
cord-341050-hnuogpqn	51	27	[	[	-LRB-
cord-341050-hnuogpqn	51	28	40	40	CD
cord-341050-hnuogpqn	51	29	,	,	,
cord-341050-hnuogpqn	51	30	44	44	CD
cord-341050-hnuogpqn	51	31	,	,	,
cord-341050-hnuogpqn	51	32	78	78	CD
cord-341050-hnuogpqn	51	33	,	,	,
cord-341050-hnuogpqn	51	34	79	79	CD
cord-341050-hnuogpqn	51	35	]	]	-RRB-
cord-341050-hnuogpqn	51	36	.	.	.
cord-341050-hnuogpqn	52	1	In	in	IN
cord-341050-hnuogpqn	52	2	addition	addition	NN
cord-341050-hnuogpqn	52	3	to	to	IN
cord-341050-hnuogpqn	52	4	humoral	humoral	JJ
cord-341050-hnuogpqn	52	5	immune	immune	JJ
cord-341050-hnuogpqn	52	6	response	response	NN
cord-341050-hnuogpqn	52	7	,	,	,
cord-341050-hnuogpqn	52	8	cell	cell	NN
cord-341050-hnuogpqn	52	9	mediated	mediate	VBN
cord-341050-hnuogpqn	52	10	immunity	immunity	NN
cord-341050-hnuogpqn	52	11	by	by	IN
cord-341050-hnuogpqn	52	12	CD4	CD4	NNP
cord-341050-hnuogpqn	52	13	+	+	CC
cord-341050-hnuogpqn	52	14	and	and	CC
cord-341050-hnuogpqn	52	15	CD8	CD8	NNP
cord-341050-hnuogpqn	52	16	+	+	CC
cord-341050-hnuogpqn	52	17	T	T	NNP
cord-341050-hnuogpqn	52	18	cells	cell	NNS
cord-341050-hnuogpqn	52	19	play	play	VBP
cord-341050-hnuogpqn	52	20	critical	critical	JJ
cord-341050-hnuogpqn	52	21	roles	role	NNS
cord-341050-hnuogpqn	52	22	in	in	IN
cord-341050-hnuogpqn	52	23	recovery	recovery	NN
cord-341050-hnuogpqn	52	24	from	from	IN
cord-341050-hnuogpqn	52	25	WNV	WNV	NNP
cord-341050-hnuogpqn	52	26	infections	infection	NNS
cord-341050-hnuogpqn	52	27	[	[	-LRB-
cord-341050-hnuogpqn	52	28	80	80	CD
cord-341050-hnuogpqn	52	29	-83	-83	NNPS
cord-341050-hnuogpqn	52	30	]	]	-RRB-
cord-341050-hnuogpqn	52	31	.	.	.
cord-341050-hnuogpqn	53	1	Thus	thus	RB
cord-341050-hnuogpqn	53	2	,	,	,
cord-341050-hnuogpqn	53	3	the	the	DT
cord-341050-hnuogpqn	53	4	effi	effi	NNP
cord-341050-hnuogpqn	53	5	cient	cient	NNP
cord-341050-hnuogpqn	53	6	generation	generation	NN
cord-341050-hnuogpqn	53	7	of	of	IN
cord-341050-hnuogpqn	53	8	vaccineinduced	vaccineinduce	VBN
cord-341050-hnuogpqn	53	9	immunity	immunity	NN
cord-341050-hnuogpqn	53	10	against	against	IN
cord-341050-hnuogpqn	53	11	WNV	WNV	NNP
cord-341050-hnuogpqn	53	12	may	may	MD
cord-341050-hnuogpqn	53	13	also	also	RB
cord-341050-hnuogpqn	53	14	require	require	VB
cord-341050-hnuogpqn	53	15	activating	activate	VBG
cord-341050-hnuogpqn	53	16	and	and	CC
cord-341050-hnuogpqn	53	17	shaping	shape	VBG
cord-341050-hnuogpqn	53	18	of	of	IN
cord-341050-hnuogpqn	53	19	multiple	multiple	JJ
cord-341050-hnuogpqn	53	20	effectors	effector	NNS
cord-341050-hnuogpqn	53	21	of	of	IN
cord-341050-hnuogpqn	53	22	adaptive	adaptive	JJ
cord-341050-hnuogpqn	53	23	immune	immune	JJ
cord-341050-hnuogpqn	53	24	response	response	NN
cord-341050-hnuogpqn	53	25	by	by	IN
cord-341050-hnuogpqn	53	26	early	early	JJ
cord-341050-hnuogpqn	53	27	innate	innate	JJ
cord-341050-hnuogpqn	53	28	signaling	signal	VBG
cord-341050-hnuogpqn	53	29	pathways	pathway	NNS
cord-341050-hnuogpqn	53	30	[	[	-LRB-
cord-341050-hnuogpqn	53	31	84	84	CD
cord-341050-hnuogpqn	53	32	-86	-86	NNP
cord-341050-hnuogpqn	53	33	]	]	-RRB-
cord-341050-hnuogpqn	53	34	.	.	.
cord-341050-hnuogpqn	54	1	Development	development	NN
cord-341050-hnuogpqn	54	2	of	of	IN
cord-341050-hnuogpqn	54	3	an	an	DT
cord-341050-hnuogpqn	54	4	effective	effective	JJ
cord-341050-hnuogpqn	54	5	vaccine	vaccine	NN
cord-341050-hnuogpqn	54	6	requires	require	VBZ
cord-341050-hnuogpqn	54	7	multiple	multiple	JJ
cord-341050-hnuogpqn	54	8	steps	step	NNS
cord-341050-hnuogpqn	54	9	from	from	IN
cord-341050-hnuogpqn	54	10	design	design	NN
cord-341050-hnuogpqn	54	11	and	and	CC
cord-341050-hnuogpqn	54	12	development	development	NN
cord-341050-hnuogpqn	54	13	to	to	IN
cord-341050-hnuogpqn	54	14	rigorous	rigorous	JJ
cord-341050-hnuogpqn	54	15	evaluation	evaluation	NN
cord-341050-hnuogpqn	54	16	of	of	IN
cord-341050-hnuogpqn	54	17	both	both	DT
cord-341050-hnuogpqn	54	18	safety	safety	NN
cord-341050-hnuogpqn	54	19	and	and	CC
cord-341050-hnuogpqn	54	20	effi	effi	NNP
cord-341050-hnuogpqn	54	21	cacy	cacy	NNP
cord-341050-hnuogpqn	55	1	(	(	-LRB-
cord-341050-hnuogpqn	55	2	Fig	Fig	NNP
cord-341050-hnuogpqn	55	3	.	.	NNP
cord-341050-hnuogpqn	55	4	1	1	CD
cord-341050-hnuogpqn	55	5	)	)	-RRB-
cord-341050-hnuogpqn	55	6	.	.	.
cord-341050-hnuogpqn	56	1	Since	since	IN
cord-341050-hnuogpqn	56	2	the	the	DT
cord-341050-hnuogpqn	56	3	biology	biology	NN
cord-341050-hnuogpqn	56	4	of	of	IN
cord-341050-hnuogpqn	56	5	vaccine	vaccine	NN
cord-341050-hnuogpqn	56	6	-	-	HYPH
cord-341050-hnuogpqn	56	7	induced	induce	VBN
cord-341050-hnuogpqn	56	8	immunity	immunity	NN
cord-341050-hnuogpqn	56	9	and	and	CC
cord-341050-hnuogpqn	56	10	principles	principle	NNS
cord-341050-hnuogpqn	56	11	in	in	IN
cord-341050-hnuogpqn	56	12	vaccine	vaccine	NN
cord-341050-hnuogpqn	56	13	development	development	NN
cord-341050-hnuogpqn	56	14	and	and	CC
cord-341050-hnuogpqn	56	15	testing	testing	NN
cord-341050-hnuogpqn	56	16	have	have	VBP
cord-341050-hnuogpqn	56	17	been	be	VBN
cord-341050-hnuogpqn	56	18	extensively	extensively	RB
cord-341050-hnuogpqn	56	19	discussed	discuss	VBN
cord-341050-hnuogpqn	56	20	before	before	RB
cord-341050-hnuogpqn	56	21	,	,	,
cord-341050-hnuogpqn	56	22	we	-PRON-	PRP
cord-341050-hnuogpqn	56	23	will	will	MD
cord-341050-hnuogpqn	56	24	not	not	RB
cord-341050-hnuogpqn	56	25	discuss	discuss	VB
cord-341050-hnuogpqn	56	26	these	these	DT
cord-341050-hnuogpqn	56	27	topics	topic	NNS
cord-341050-hnuogpqn	56	28	here	here	RB
cord-341050-hnuogpqn	56	29	.	.	.
cord-341050-hnuogpqn	57	1	Immunization	immunization	NN
cord-341050-hnuogpqn	57	2	of	of	IN
cord-341050-hnuogpqn	57	3	the	the	DT
cord-341050-hnuogpqn	57	4	laboratory	laboratory	NN
cord-341050-hnuogpqn	57	5	animals	animal	NNS
cord-341050-hnuogpqn	57	6	and	and	CC
cord-341050-hnuogpqn	57	7	subsequent	subsequent	JJ
cord-341050-hnuogpqn	57	8	challenge	challenge	NN
cord-341050-hnuogpqn	57	9	of	of	IN
cord-341050-hnuogpqn	57	10	those	those	DT
cord-341050-hnuogpqn	57	11	animals	animal	NNS
cord-341050-hnuogpqn	57	12	with	with	IN
cord-341050-hnuogpqn	57	13	a	a	DT
cord-341050-hnuogpqn	57	14	pathogen	pathogen	NN
cord-341050-hnuogpqn	57	15	under	under	IN
cord-341050-hnuogpqn	57	16	controlled	control	VBN
cord-341050-hnuogpqn	57	17	conditions	condition	NNS
cord-341050-hnuogpqn	57	18	is	be	VBZ
cord-341050-hnuogpqn	57	19	the	the	DT
cord-341050-hnuogpqn	57	20	common	common	JJ
cord-341050-hnuogpqn	57	21	method	method	NN
cord-341050-hnuogpqn	57	22	for	for	IN
cord-341050-hnuogpqn	57	23	early	early	JJ
cord-341050-hnuogpqn	57	24	evaluation	evaluation	NN
cord-341050-hnuogpqn	57	25	of	of	IN
cord-341050-hnuogpqn	57	26	vaccine	vaccine	NN
cord-341050-hnuogpqn	57	27	effectiveness	effectiveness	NN
cord-341050-hnuogpqn	57	28	.	.	.
cord-341050-hnuogpqn	58	1	Introduction	introduction	NN
cord-341050-hnuogpqn	58	2	of	of	IN
cord-341050-hnuogpqn	58	3	three	three	CD
cord-341050-hnuogpqn	58	4	mutations	mutation	NNS
cord-341050-hnuogpqn	58	5	responsible	responsible	JJ
cord-341050-hnuogpqn	58	6	for	for	IN
cord-341050-hnuogpqn	58	7	attenuation	attenuation	NN
cord-341050-hnuogpqn	58	8	of	of	IN
cord-341050-hnuogpqn	58	9	JEV	JEV	NNP
cord-341050-hnuogpqn	58	10	(	(	-LRB-
cord-341050-hnuogpqn	58	11	SA14	SA14	NNP
cord-341050-hnuogpqn	58	12	-	-	HYPH
cord-341050-hnuogpqn	58	13	14	14	CD
cord-341050-hnuogpqn	58	14	-	-	SYM
cord-341050-hnuogpqn	58	15	2	2	CD
cord-341050-hnuogpqn	58	16	)	)	-RRB-
cord-341050-hnuogpqn	58	17	in	in	IN
cord-341050-hnuogpqn	58	18	equivalent	equivalent	JJ
cord-341050-hnuogpqn	58	19	positions	position	NNS
cord-341050-hnuogpqn	58	20	of	of	IN
cord-341050-hnuogpqn	58	21	WNV	WNV	NNP
cord-341050-hnuogpqn	58	22	E	e	NN
cord-341050-hnuogpqn	58	23	gene	gene	NN
cord-341050-hnuogpqn	58	24	further	further	RB
cord-341050-hnuogpqn	58	25	attenuated	attenuate	VBN
cord-341050-hnuogpqn	58	26	ChimeriVax	ChimeriVax	NNP
cord-341050-hnuogpqn	58	27	-	-	HYPH
cord-341050-hnuogpqn	58	28	WN02	WN02	NNP
cord-341050-hnuogpqn	58	29	.	.	.
cord-341050-hnuogpqn	59	1	Similarly	similarly	RB
cord-341050-hnuogpqn	59	2	,	,	,
cord-341050-hnuogpqn	59	3	DENV4	DENV4	NNP
cord-341050-hnuogpqn	59	4	vaccine	vaccine	NN
cord-341050-hnuogpqn	59	5	candidate	candidate	NN
cord-341050-hnuogpqn	59	6	(	(	-LRB-
cord-341050-hnuogpqn	59	7	rDEN4Δ30	rDEN4Δ30	NNP
cord-341050-hnuogpqn	59	8	)	)	-RRB-
cord-341050-hnuogpqn	59	9	,	,	,
cord-341050-hnuogpqn	59	10	attenuated	attenuate	VBN
cord-341050-hnuogpqn	59	11	through	through	IN
cord-341050-hnuogpqn	59	12	a	a	DT
cord-341050-hnuogpqn	59	13	30-nucleotide	30-nucleotide	CD
cord-341050-hnuogpqn	59	14	deletion	deletion	NN
cord-341050-hnuogpqn	59	15	in	in	IN
cord-341050-hnuogpqn	59	16	the	the	DT
cord-341050-hnuogpqn	59	17	3′	3′	CD
cord-341050-hnuogpqn	59	18	untranslated	untranslated	JJ
cord-341050-hnuogpqn	59	19	region	region	NN
cord-341050-hnuogpqn	59	20	(	(	-LRB-
cord-341050-hnuogpqn	59	21	UTR	UTR	NNP
cord-341050-hnuogpqn	59	22	)	)	-RRB-
cord-341050-hnuogpqn	59	23	of	of	IN
cord-341050-hnuogpqn	59	24	the	the	DT
cord-341050-hnuogpqn	59	25	viral	viral	JJ
cord-341050-hnuogpqn	59	26	genome	genome	NN
cord-341050-hnuogpqn	59	27	,	,	,
cord-341050-hnuogpqn	59	28	was	be	VBD
cord-341050-hnuogpqn	59	29	further	further	RB
cord-341050-hnuogpqn	59	30	engineered	engineer	VBN
cord-341050-hnuogpqn	59	31	to	to	TO
cord-341050-hnuogpqn	59	32	express	express	VB
cord-341050-hnuogpqn	59	33	WNV	WNV	NNP
cord-341050-hnuogpqn	59	34	-	-	HYPH
cord-341050-hnuogpqn	59	35	NY99	NY99	NNP
cord-341050-hnuogpqn	59	36	prM	prm	JJ
cord-341050-hnuogpqn	59	37	and	and	CC
cord-341050-hnuogpqn	59	38	E	e	JJ
cord-341050-hnuogpqn	59	39	[	[	-LRB-
cord-341050-hnuogpqn	59	40	122	122	CD
cord-341050-hnuogpqn	59	41	,	,	,
cord-341050-hnuogpqn	59	42	123	123	CD
cord-341050-hnuogpqn	59	43	]	]	-RRB-
cord-341050-hnuogpqn	59	44	.	.	.
cord-341050-hnuogpqn	60	1	After	after	IN
cord-341050-hnuogpqn	60	2	preclinical	preclinical	JJ
cord-341050-hnuogpqn	60	3	evaluation	evaluation	NN
cord-341050-hnuogpqn	60	4	in	in	IN
cord-341050-hnuogpqn	60	5	mice	mouse	NNS
cord-341050-hnuogpqn	60	6	,	,	,
cord-341050-hnuogpqn	60	7	geese	goose	NNS
cord-341050-hnuogpqn	60	8	,	,	,
cord-341050-hnuogpqn	60	9	and	and	CC
cord-341050-hnuogpqn	60	10	monkeys	monkey	NNS
cord-341050-hnuogpqn	60	11	,	,	,
cord-341050-hnuogpqn	60	12	rDEN4Δ30	rDEN4Δ30	NNP
cord-341050-hnuogpqn	60	13	showed	show	VBD
cord-341050-hnuogpqn	60	14	strong	strong	JJ
cord-341050-hnuogpqn	60	15	immunogenicity	immunogenicity	NN
cord-341050-hnuogpqn	60	16	in	in	IN
cord-341050-hnuogpqn	60	17	the	the	DT
cord-341050-hnuogpqn	60	18	clinical	clinical	JJ
cord-341050-hnuogpqn	60	19	trial	trial	NN
cord-341050-hnuogpqn	60	20	[	[	-LRB-
cord-341050-hnuogpqn	60	21	94	94	CD
cord-341050-hnuogpqn	60	22	]	]	-RRB-
cord-341050-hnuogpqn	60	23	.	.	.
cord-341050-hnuogpqn	61	1	In	in	IN
cord-341050-hnuogpqn	61	2	addition	addition	NN
cord-341050-hnuogpqn	61	3	,	,	,
cord-341050-hnuogpqn	61	4	a	a	DT
cord-341050-hnuogpqn	61	5	chimeric	chimeric	JJ
cord-341050-hnuogpqn	61	6	DENV2	denv2	NN
cord-341050-hnuogpqn	61	7	vaccine	vaccine	NN
cord-341050-hnuogpqn	61	8	candidate	candidate	NN
cord-341050-hnuogpqn	61	9	expressing	express	VBG
cord-341050-hnuogpqn	61	10	the	the	DT
cord-341050-hnuogpqn	61	11	WNV	WNV	NNP
cord-341050-hnuogpqn	61	12	NY99	NY99	NNP
cord-341050-hnuogpqn	61	13	prM	prm	JJ
cord-341050-hnuogpqn	61	14	and	and	CC
cord-341050-hnuogpqn	61	15	E	e	NN
cord-341050-hnuogpqn	61	16	proteins	protein	NNS
cord-341050-hnuogpqn	61	17	has	have	VBZ
cord-341050-hnuogpqn	61	18	been	be	VBN
cord-341050-hnuogpqn	61	19	shown	show	VBN
cord-341050-hnuogpqn	61	20	to	to	TO
cord-341050-hnuogpqn	61	21	protect	protect	VB
cord-341050-hnuogpqn	61	22	mice	mouse	NNS
cord-341050-hnuogpqn	61	23	from	from	IN
cord-341050-hnuogpqn	61	24	infection	infection	NN
cord-341050-hnuogpqn	61	25	with	with	IN
cord-341050-hnuogpqn	61	26	WNV	WNV	NNP
cord-341050-hnuogpqn	61	27	NY99	NY99	NNP
cord-341050-hnuogpqn	61	28	strain	strain	NN
cord-341050-hnuogpqn	61	29	[	[	-LRB-
cord-341050-hnuogpqn	61	30	124	124	CD
cord-341050-hnuogpqn	61	31	]	]	-RRB-
cord-341050-hnuogpqn	61	32	.	.	.
cord-341050-hnuogpqn	62	1	Another	another	DT
cord-341050-hnuogpqn	62	2	recombinant	recombinant	JJ
cord-341050-hnuogpqn	62	3	WNV	WNV	NNP
cord-341050-hnuogpqn	62	4	vaccine	vaccine	NN
cord-341050-hnuogpqn	62	5	based	base	VBN
cord-341050-hnuogpqn	62	6	on	on	IN
cord-341050-hnuogpqn	62	7	infl	infl	NNP
cord-341050-hnuogpqn	62	8	uenza	uenza	NNP
cord-341050-hnuogpqn	62	9	vaccine	vaccine	NN
cord-341050-hnuogpqn	62	10	(	(	-LRB-
cord-341050-hnuogpqn	62	11	FLU	FLU	NNP
cord-341050-hnuogpqn	62	12	-	-	HYPH
cord-341050-hnuogpqn	62	13	NA	NA	NNP
cord-341050-hnuogpqn	62	14	-	-	HYPH
cord-341050-hnuogpqn	62	15	DIII	DIII	NNP
cord-341050-hnuogpqn	62	16	)	)	-RRB-
cord-341050-hnuogpqn	62	17	was	be	VBD
cord-341050-hnuogpqn	62	18	developed	develop	VBN
cord-341050-hnuogpqn	62	19	by	by	IN
cord-341050-hnuogpqn	62	20	cloning	clone	VBG
cord-341050-hnuogpqn	62	21	DIII	DIII	NNP
cord-341050-hnuogpqn	62	22	of	of	IN
cord-341050-hnuogpqn	62	23	WNV	WNV	NNP
cord-341050-hnuogpqn	62	24	E	E	NNP
cord-341050-hnuogpqn	62	25	into	into	IN
cord-341050-hnuogpqn	62	26	the	the	DT
cord-341050-hnuogpqn	62	27	N	n	CD
cord-341050-hnuogpqn	62	28	-	-	HYPH
cord-341050-hnuogpqn	62	29	terminal	terminal	JJ
cord-341050-hnuogpqn	62	30	region	region	NN
cord-341050-hnuogpqn	62	31	of	of	IN
cord-341050-hnuogpqn	62	32	neuraminidase	neuraminidase	NN
cord-341050-hnuogpqn	62	33	of	of	IN
cord-341050-hnuogpqn	62	34	infl	infl	NNP
cord-341050-hnuogpqn	62	35	uenza	uenza	NNP
cord-341050-hnuogpqn	62	36	virus	virus	NN
cord-341050-hnuogpqn	62	37	.	.	.
cord-341050-hnuogpqn	63	1	This	this	DT
cord-341050-hnuogpqn	63	2	vaccine	vaccine	NN
cord-341050-hnuogpqn	63	3	candidate	candidate	NN
cord-341050-hnuogpqn	63	4	induced	induce	VBN
cord-341050-hnuogpqn	63	5	WNV	WNV	NNP
cord-341050-hnuogpqn	63	6	-	-	HYPH
cord-341050-hnuogpqn	63	7	specifi	specifi	NNP
cord-341050-hnuogpqn	63	8	c	c	NN
cord-341050-hnuogpqn	63	9	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	63	10	IgG	IgG	NNP
cord-341050-hnuogpqn	63	11	and	and	CC
cord-341050-hnuogpqn	63	12	protected	protect	VBD
cord-341050-hnuogpqn	63	13	mice	mouse	NNS
cord-341050-hnuogpqn	63	14	against	against	IN
cord-341050-hnuogpqn	63	15	lethal	lethal	JJ
cord-341050-hnuogpqn	63	16	WNV	WNV	NNP
cord-341050-hnuogpqn	63	17	infection	infection	NN
cord-341050-hnuogpqn	63	18	[	[	-LRB-
cord-341050-hnuogpqn	63	19	125	125	CD
cord-341050-hnuogpqn	63	20	]	]	-RRB-
cord-341050-hnuogpqn	63	21	.	.	.
cord-341050-hnuogpqn	64	1	Similarly	similarly	RB
cord-341050-hnuogpqn	64	2	,	,	,
cord-341050-hnuogpqn	64	3	a	a	DT
cord-341050-hnuogpqn	64	4	recombinant	recombinant	JJ
cord-341050-hnuogpqn	64	5	adenoviral	adenoviral	JJ
cord-341050-hnuogpqn	64	6	vaccine	vaccine	NN
cord-341050-hnuogpqn	64	7	vector	vector	NN
cord-341050-hnuogpqn	64	8	(	(	-LRB-
cord-341050-hnuogpqn	64	9	CAdVax	CAdVax	NNP
cord-341050-hnuogpqn	64	10	-	-	HYPH
cord-341050-hnuogpqn	64	11	WNVII	WNVII	NNP
cord-341050-hnuogpqn	64	12	)	)	-RRB-
cord-341050-hnuogpqn	64	13	expressing	express	VBG
cord-341050-hnuogpqn	64	14	all	all	DT
cord-341050-hnuogpqn	64	15	three	three	CD
cord-341050-hnuogpqn	64	16	structural	structural	JJ
cord-341050-hnuogpqn	64	17	proteins	protein	NNS
cord-341050-hnuogpqn	64	18	(	(	-LRB-
cord-341050-hnuogpqn	64	19	C	C	NNP
cord-341050-hnuogpqn	64	20	,	,	,
cord-341050-hnuogpqn	64	21	prM	prm	JJ
cord-341050-hnuogpqn	64	22	,	,	,
cord-341050-hnuogpqn	64	23	and	and	CC
cord-341050-hnuogpqn	64	24	E	e	LS
cord-341050-hnuogpqn	64	25	)	)	-RRB-
cord-341050-hnuogpqn	64	26	along	along	IN
cord-341050-hnuogpqn	64	27	with	with	IN
cord-341050-hnuogpqn	64	28	NS1	NS1	NNS
cord-341050-hnuogpqn	64	29	of	of	IN
cord-341050-hnuogpqn	64	30	WNV	WNV	NNP
cord-341050-hnuogpqn	64	31	induced	induce	VBN
cord-341050-hnuogpqn	64	32	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	64	33	antibodies	antibody	NNS
cord-341050-hnuogpqn	64	34	in	in	IN
cord-341050-hnuogpqn	64	35	mice	mouse	NNS
cord-341050-hnuogpqn	64	36	[	[	-LRB-
cord-341050-hnuogpqn	64	37	 	 	_SP
cord-341050-hnuogpqn	64	38	The	the	DT
cord-341050-hnuogpqn	64	39	most	most	RBS
cord-341050-hnuogpqn	64	40	common	common	JJ
cord-341050-hnuogpqn	64	41	approach	approach	NN
cord-341050-hnuogpqn	64	42	to	to	TO
cord-341050-hnuogpqn	64	43	develop	develop	VB
cord-341050-hnuogpqn	64	44	non	non	JJ
cord-341050-hnuogpqn	64	45	-	-	JJ
cord-341050-hnuogpqn	64	46	replicating	replicating	JJ
cord-341050-hnuogpqn	64	47	inactivated	inactivate	VBN
cord-341050-hnuogpqn	64	48	viral	viral	JJ
cord-341050-hnuogpqn	64	49	vaccines	vaccine	NNS
cord-341050-hnuogpqn	64	50	is	be	VBZ
cord-341050-hnuogpqn	64	51	to	to	TO
cord-341050-hnuogpqn	64	52	inactivate	inactivate	VB
cord-341050-hnuogpqn	64	53	entire	entire	JJ
cord-341050-hnuogpqn	64	54	virus	virus	NN
cord-341050-hnuogpqn	64	55	particles	particle	NNS
cord-341050-hnuogpqn	64	56	by	by	IN
cord-341050-hnuogpqn	64	57	using	use	VBG
cord-341050-hnuogpqn	64	58	chemicals	chemical	NNS
cord-341050-hnuogpqn	64	59	.	.	.
cord-341050-hnuogpqn	65	1	A	a	DT
cord-341050-hnuogpqn	65	2	formalin	formalin	NN
cord-341050-hnuogpqn	65	3	-	-	HYPH
cord-341050-hnuogpqn	65	4	inactivated	inactivate	VBN
cord-341050-hnuogpqn	65	5	WNV	WNV	NNP
cord-341050-hnuogpqn	65	6	vaccine	vaccine	NN
cord-341050-hnuogpqn	65	7	based	base	VBN
cord-341050-hnuogpqn	65	8	on	on	IN
cord-341050-hnuogpqn	65	9	WNV	WNV	NNP
cord-341050-hnuogpqn	65	10	-	-	HYPH
cord-341050-hnuogpqn	65	11	NY99	NY99	NNP
cord-341050-hnuogpqn	65	12	strain	strain	NN
cord-341050-hnuogpqn	65	13	was	be	VBD
cord-341050-hnuogpqn	65	14	the	the	DT
cord-341050-hnuogpqn	65	15	fi	fi	NNP
cord-341050-hnuogpqn	65	16	rst	rst	NNP
cord-341050-hnuogpqn	65	17	successful	successful	JJ
cord-341050-hnuogpqn	65	18	veterinary	veterinary	JJ
cord-341050-hnuogpqn	65	19	vaccine	vaccine	NN
cord-341050-hnuogpqn	65	20	(	(	-LRB-
cord-341050-hnuogpqn	65	21	marketed	market	VBN
cord-341050-hnuogpqn	65	22	by	by	IN
cord-341050-hnuogpqn	65	23	Pfi	Pfi	NNP
cord-341050-hnuogpqn	65	24	zer	zer	NNP
cord-341050-hnuogpqn	65	25	as	as	IN
cord-341050-hnuogpqn	65	26	West	West	NNP
cord-341050-hnuogpqn	65	27	Nile	Nile	NNP
cord-341050-hnuogpqn	65	28	Innovator	Innovator	NNP
cord-341050-hnuogpqn	65	29	®	®	.
cord-341050-hnuogpqn	65	30	)	)	-RRB-
cord-341050-hnuogpqn	65	31	licensed	license	VBN
cord-341050-hnuogpqn	65	32	in	in	IN
cord-341050-hnuogpqn	65	33	2003	2003	CD
cord-341050-hnuogpqn	65	34	[	[	-LRB-
cord-341050-hnuogpqn	65	35	127	127	CD
cord-341050-hnuogpqn	65	36	]	]	-RRB-
cord-341050-hnuogpqn	65	37	.	.	.
cord-341050-hnuogpqn	66	1	Another	another	DT
cord-341050-hnuogpqn	66	2	veterinary	veterinary	JJ
cord-341050-hnuogpqn	66	3	WNV	WNV	NNP
cord-341050-hnuogpqn	66	4	vaccine	vaccine	NN
cord-341050-hnuogpqn	66	5	using	use	VBG
cord-341050-hnuogpqn	66	6	killed	kill	VBN
cord-341050-hnuogpqn	66	7	virus	virus	NN
cord-341050-hnuogpqn	66	8	was	be	VBD
cord-341050-hnuogpqn	66	9	also	also	RB
cord-341050-hnuogpqn	66	10	licensed	license	VBN
cord-341050-hnuogpqn	66	11	by	by	IN
cord-341050-hnuogpqn	66	12	USDA	USDA	NNP
cord-341050-hnuogpqn	66	13	(	(	-LRB-
cord-341050-hnuogpqn	66	14	marketed	market	VBN
cord-341050-hnuogpqn	66	15	by	by	IN
cord-341050-hnuogpqn	66	16	Boehringer	Boehringer	NNP
cord-341050-hnuogpqn	66	17	Ingelheim	Ingelheim	NNP
cord-341050-hnuogpqn	66	18	as	as	IN
cord-341050-hnuogpqn	66	19	Vetera	Vetera	NNP
cord-341050-hnuogpqn	66	20	™	™	HYPH
cord-341050-hnuogpqn	66	21	WNV	WNV	NNP
cord-341050-hnuogpqn	66	22	)	)	-RRB-
cord-341050-hnuogpqn	66	23	.	.	.
cord-341050-hnuogpqn	67	1	Recently	recently	RB
cord-341050-hnuogpqn	67	2	,	,	,
cord-341050-hnuogpqn	67	3	an	an	DT
cord-341050-hnuogpqn	67	4	inactivated	inactivate	VBN
cord-341050-hnuogpqn	67	5	WNV	WNV	NNP
cord-341050-hnuogpqn	67	6	vaccine	vaccine	NN
cord-341050-hnuogpqn	67	7	(	(	-LRB-
cord-341050-hnuogpqn	67	8	WN	WN	NNP
cord-341050-hnuogpqn	67	9	-	-	HYPH
cord-341050-hnuogpqn	67	10	VAX	VAX	NNP
cord-341050-hnuogpqn	67	11	)	)	-RRB-
cord-341050-hnuogpqn	67	12	based	base	VBN
cord-341050-hnuogpqn	67	13	on	on	IN
cord-341050-hnuogpqn	67	14	WNV	WNV	NNP
cord-341050-hnuogpqn	67	15	NY99	NY99	NNP
cord-341050-hnuogpqn	67	16	protects	protect	VBZ
cord-341050-hnuogpqn	67	17	mice	mouse	NNS
cord-341050-hnuogpqn	67	18	against	against	IN
cord-341050-hnuogpqn	67	19	lethal	lethal	JJ
cord-341050-hnuogpqn	67	20	WNV	WNV	NNP
cord-341050-hnuogpqn	67	21	infection	infection	NN
cord-341050-hnuogpqn	67	22	and	and	CC
cord-341050-hnuogpqn	67	23	exhibits	exhibit	VBZ
cord-341050-hnuogpqn	67	24	immunogenicity	immunogenicity	NN
cord-341050-hnuogpqn	67	25	in	in	IN
cord-341050-hnuogpqn	67	26	monkeys	monkey	NNS
cord-341050-hnuogpqn	67	27	[	[	-LRB-
cord-341050-hnuogpqn	67	28	128	128	CD
cord-341050-hnuogpqn	67	29	]	]	-RRB-
cord-341050-hnuogpqn	67	30	.	.	.
cord-341050-hnuogpqn	68	1	In	in	IN
cord-341050-hnuogpqn	68	2	addition	addition	NN
cord-341050-hnuogpqn	68	3	to	to	IN
cord-341050-hnuogpqn	68	4	WNV	WNV	NNP
cord-341050-hnuogpqn	68	5	NY99	NY99	NNP
cord-341050-hnuogpqn	68	6	,	,	,
cord-341050-hnuogpqn	68	7	formalin	formalin	NN
cord-341050-hnuogpqn	68	8	inactivation	inactivation	NN
cord-341050-hnuogpqn	68	9	of	of	IN
cord-341050-hnuogpqn	69	1	WNV	WNV	NNP
cord-341050-hnuogpqn	69	2	IRS98	IRS98	NNP
cord-341050-hnuogpqn	69	3	strain	strain	NN
cord-341050-hnuogpqn	69	4	induces	induce	VBZ
cord-341050-hnuogpqn	69	5	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	69	6	antibody	antibody	NN
cord-341050-hnuogpqn	69	7	and	and	CC
cord-341050-hnuogpqn	69	8	protects	protect	VBZ
cord-341050-hnuogpqn	69	9	immunized	immunize	VBN
cord-341050-hnuogpqn	69	10	geese	goose	NNS
cord-341050-hnuogpqn	69	11	[	[	-LRB-
cord-341050-hnuogpqn	69	12	129	129	CD
cord-341050-hnuogpqn	69	13	]	]	-RRB-
cord-341050-hnuogpqn	69	14	.	.	.
cord-341050-hnuogpqn	70	1	As	as	IN
cord-341050-hnuogpqn	70	2	an	an	DT
cord-341050-hnuogpqn	70	3	alternative	alternative	NN
cord-341050-hnuogpqn	70	4	to	to	IN
cord-341050-hnuogpqn	70	5	traditional	traditional	JJ
cord-341050-hnuogpqn	70	6	formalin	formalin	NN
cord-341050-hnuogpqn	70	7	-	-	HYPH
cord-341050-hnuogpqn	70	8	based	base	VBN
cord-341050-hnuogpqn	70	9	vaccines	vaccine	NNS
cord-341050-hnuogpqn	70	10	,	,	,
cord-341050-hnuogpqn	70	11	a	a	DT
cord-341050-hnuogpqn	70	12	novel	novel	JJ
cord-341050-hnuogpqn	70	13	hydrogen	hydrogen	NN
cord-341050-hnuogpqn	70	14	peroxide	peroxide	NN
cord-341050-hnuogpqn	70	15	(	(	-LRB-
cord-341050-hnuogpqn	70	16	H	h	NN
cord-341050-hnuogpqn	70	17	2	2	CD
cord-341050-hnuogpqn	70	18	O	o	NN
cord-341050-hnuogpqn	70	19	2	2	CD
cord-341050-hnuogpqn	70	20	)	)	-RRB-
cord-341050-hnuogpqn	70	21	inactivation	inactivation	NN
cord-341050-hnuogpqn	70	22	approach	approach	NN
cord-341050-hnuogpqn	70	23	has	have	VBZ
cord-341050-hnuogpqn	70	24	been	be	VBN
cord-341050-hnuogpqn	70	25	recently	recently	RB
cord-341050-hnuogpqn	70	26	used	use	VBN
cord-341050-hnuogpqn	70	27	to	to	TO
cord-341050-hnuogpqn	70	28	produce	produce	VB
cord-341050-hnuogpqn	70	29	a	a	DT
cord-341050-hnuogpqn	70	30	wholevirus	wholevirus	NN
cord-341050-hnuogpqn	70	31	vaccine	vaccine	NN
cord-341050-hnuogpqn	70	32	against	against	IN
cord-341050-hnuogpqn	70	33	WNV	WNV	NNP
cord-341050-hnuogpqn	70	34	[	[	-LRB-
cord-341050-hnuogpqn	70	35	130	130	CD
cord-341050-hnuogpqn	70	36	,	,	,
cord-341050-hnuogpqn	70	37	131	131	CD
cord-341050-hnuogpqn	70	38	]	]	-RRB-
cord-341050-hnuogpqn	70	39	.	.	.
cord-341050-hnuogpqn	71	1	Mice	mouse	NNS
cord-341050-hnuogpqn	71	2	immunized	immunize	VBD
cord-341050-hnuogpqn	71	3	with	with	IN
cord-341050-hnuogpqn	71	4	H	H	NNP
cord-341050-hnuogpqn	71	5	2	2	CD
cord-341050-hnuogpqn	71	6	O	o	CD
cord-341050-hnuogpqn	71	7	2	2	CD
cord-341050-hnuogpqn	71	8	-inactivated	-inactivated	JJ
cord-341050-hnuogpqn	71	9	WNV	WNV	NNP
cord-341050-hnuogpqn	71	10	vaccine	vaccine	NN
cord-341050-hnuogpqn	71	11	candidate	candidate	NN
cord-341050-hnuogpqn	71	12	developed	develop	VBD
cord-341050-hnuogpqn	71	13	high	high	JJ
cord-341050-hnuogpqn	71	14	serum	serum	NN
cord-341050-hnuogpqn	71	15	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	71	16	titers	titer	NNS
cord-341050-hnuogpqn	71	17	,	,	,
cord-341050-hnuogpqn	71	18	and	and	CC
cord-341050-hnuogpqn	71	19	offered	offer	VBD
cord-341050-hnuogpqn	71	20	complete	complete	JJ
cord-341050-hnuogpqn	71	21	protection	protection	NN
cord-341050-hnuogpqn	71	22	of	of	IN
cord-341050-hnuogpqn	71	23	vaccinated	vaccinated	JJ
cord-341050-hnuogpqn	71	24	mice	mouse	NNS
cord-341050-hnuogpqn	71	25	against	against	IN
cord-341050-hnuogpqn	71	26	lethal	lethal	JJ
cord-341050-hnuogpqn	71	27	WNV	WNV	NNP
cord-341050-hnuogpqn	71	28	challenge	challenge	NN
cord-341050-hnuogpqn	71	29	[	[	-LRB-
cord-341050-hnuogpqn	71	30	130	130	CD
cord-341050-hnuogpqn	71	31	]	]	-RRB-
cord-341050-hnuogpqn	71	32	.	.	.
cord-341050-hnuogpqn	72	1	One	one	CD
cord-341050-hnuogpqn	72	2	of	of	IN
cord-341050-hnuogpqn	72	3	such	such	JJ
cord-341050-hnuogpqn	72	4	H	h	NN
cord-341050-hnuogpqn	72	5	2	2	CD
cord-341050-hnuogpqn	72	6	O	o	NN
cord-341050-hnuogpqn	72	7	2	2	CD
cord-341050-hnuogpqn	72	8	inactivated	inactivate	VBN
cord-341050-hnuogpqn	72	9	vaccine	vaccine	NN
cord-341050-hnuogpqn	72	10	(	(	-LRB-
cord-341050-hnuogpqn	72	11	HydroVax-001	HydroVax-001	NNP
cord-341050-hnuogpqn	72	12	)	)	-RRB-
cord-341050-hnuogpqn	72	13	has	have	VBZ
cord-341050-hnuogpqn	72	14	been	be	VBN
cord-341050-hnuogpqn	72	15	recently	recently	RB
cord-341050-hnuogpqn	72	16	introduced	introduce	VBN
cord-341050-hnuogpqn	72	17	into	into	IN
cord-341050-hnuogpqn	72	18	phase	phase	NN
cord-341050-hnuogpqn	72	19	I	-PRON-	PRP
cord-341050-hnuogpqn	72	20	clinical	clinical	JJ
cord-341050-hnuogpqn	72	21	trial	trial	NN
cord-341050-hnuogpqn	72	22	.	.	.
cord-341050-hnuogpqn	73	1	Although	although	IN
cord-341050-hnuogpqn	73	2	inactivation	inactivation	NN
cord-341050-hnuogpqn	73	3	of	of	IN
cord-341050-hnuogpqn	73	4	virulent	virulent	JJ
cord-341050-hnuogpqn	73	5	WNV	WNV	NNP
cord-341050-hnuogpqn	73	6	virus	virus	NN
cord-341050-hnuogpqn	73	7	strain	strain	NN
cord-341050-hnuogpqn	73	8	has	have	VBZ
cord-341050-hnuogpqn	73	9	been	be	VBN
cord-341050-hnuogpqn	73	10	successfully	successfully	RB
cord-341050-hnuogpqn	73	11	achieved	achieve	VBN
cord-341050-hnuogpqn	73	12	by	by	IN
cord-341050-hnuogpqn	73	13	chemical	chemical	NN
cord-341050-hnuogpqn	73	14	-	-	HYPH
cord-341050-hnuogpqn	73	15	inactivation	inactivation	NN
cord-341050-hnuogpqn	73	16	method	method	NN
cord-341050-hnuogpqn	73	17	[	[	-LRB-
cord-341050-hnuogpqn	73	18	127	127	CD
cord-341050-hnuogpqn	73	19	,	,	,
cord-341050-hnuogpqn	73	20	129	129	CD
cord-341050-hnuogpqn	73	21	]	]	-RRB-
cord-341050-hnuogpqn	73	22	,	,	,
cord-341050-hnuogpqn	73	23	use	use	NN
cord-341050-hnuogpqn	73	24	of	of	IN
cord-341050-hnuogpqn	73	25	a	a	DT
cord-341050-hnuogpqn	73	26	naturally	naturally	RB
cord-341050-hnuogpqn	73	27	attenuated	attenuate	VBN
cord-341050-hnuogpqn	73	28	Kunjin	Kunjin	NNP
cord-341050-hnuogpqn	73	29	strain	strain	NN
cord-341050-hnuogpqn	73	30	of	of	IN
cord-341050-hnuogpqn	73	31	WNV	WNV	NNP
cord-341050-hnuogpqn	73	32	[	[	-LRB-
cord-341050-hnuogpqn	73	33	132	132	CD
cord-341050-hnuogpqn	73	34	,	,	,
cord-341050-hnuogpqn	73	35	133	133	CD
cord-341050-hnuogpqn	73	36	]	]	-RRB-
cord-341050-hnuogpqn	73	37	,	,	,
cord-341050-hnuogpqn	73	38	or	or	CC
cord-341050-hnuogpqn	73	39	chemically	chemically	RB
cord-341050-hnuogpqn	73	40	synthesized	synthesize	VBN
cord-341050-hnuogpqn	73	41	virus	virus	NN
cord-341050-hnuogpqn	73	42	by	by	IN
cord-341050-hnuogpqn	73	43	cDNA	cdna	NN
cord-341050-hnuogpqn	73	44	system	system	NN
cord-341050-hnuogpqn	73	45	[	[	-LRB-
cord-341050-hnuogpqn	73	46	134	134	CD
cord-341050-hnuogpqn	73	47	]	]	-RRB-
cord-341050-hnuogpqn	73	48	as	as	IN
cord-341050-hnuogpqn	73	49	starting	start	VBG
cord-341050-hnuogpqn	73	50	material	material	NN
cord-341050-hnuogpqn	73	51	has	have	VBZ
cord-341050-hnuogpqn	73	52	also	also	RB
cord-341050-hnuogpqn	73	53	been	be	VBN
cord-341050-hnuogpqn	73	54	proposed	propose	VBN
cord-341050-hnuogpqn	73	55	.	.	.
cord-341050-hnuogpqn	74	1	Several	several	JJ
cord-341050-hnuogpqn	74	2	studies	study	NNS
cord-341050-hnuogpqn	74	3	demonstrated	demonstrate	VBD
cord-341050-hnuogpqn	74	4	that	that	IN
cord-341050-hnuogpqn	74	5	soluble	soluble	JJ
cord-341050-hnuogpqn	74	6	recombinant	recombinant	JJ
cord-341050-hnuogpqn	74	7	protein	protein	NN
cord-341050-hnuogpqn	74	8	or	or	CC
cord-341050-hnuogpqn	74	9	VLP	VLP	NNP
cord-341050-hnuogpqn	74	10	based	base	VBN
cord-341050-hnuogpqn	74	11	approach	approach	NN
cord-341050-hnuogpqn	74	12	could	could	MD
cord-341050-hnuogpqn	74	13	serve	serve	VB
cord-341050-hnuogpqn	74	14	to	to	TO
cord-341050-hnuogpqn	74	15	develop	develop	VB
cord-341050-hnuogpqn	74	16	WNV	WNV	NNP
cord-341050-hnuogpqn	74	17	vaccines	vaccine	NNS
cord-341050-hnuogpqn	74	18	[	[	-LRB-
cord-341050-hnuogpqn	74	19	135	135	CD
cord-341050-hnuogpqn	74	20	-139	-139	NN
cord-341050-hnuogpqn	74	21	]	]	-RRB-
cord-341050-hnuogpqn	74	22	.	.	.
cord-341050-hnuogpqn	75	1	VLP	VLP	NNP
cord-341050-hnuogpqn	75	2	are	be	VBP
cord-341050-hnuogpqn	75	3	specialized	specialized	JJ
cord-341050-hnuogpqn	75	4	subviral	subviral	JJ
cord-341050-hnuogpqn	75	5	particles	particle	NNS
cord-341050-hnuogpqn	75	6	that	that	WDT
cord-341050-hnuogpqn	75	7	lack	lack	NN
cord-341050-hnuogpqn	75	8	of	of	IN
cord-341050-hnuogpqn	75	9	viral	viral	JJ
cord-341050-hnuogpqn	75	10	genome	genome	NN
cord-341050-hnuogpqn	75	11	and	and	CC
cord-341050-hnuogpqn	75	12	solely	solely	RB
cord-341050-hnuogpqn	75	13	contain	contain	VB
cord-341050-hnuogpqn	75	14	viral	viral	JJ
cord-341050-hnuogpqn	75	15	structural	structural	JJ
cord-341050-hnuogpqn	75	16	proteins	protein	NNS
cord-341050-hnuogpqn	75	17	[	[	-LRB-
cord-341050-hnuogpqn	75	18	140	140	CD
cord-341050-hnuogpqn	75	19	,	,	,
cord-341050-hnuogpqn	75	20	141	141	CD
cord-341050-hnuogpqn	75	21	]	]	-RRB-
cord-341050-hnuogpqn	75	22	or	or	CC
cord-341050-hnuogpqn	75	23	express	express	VBP
cord-341050-hnuogpqn	75	24	viral	viral	JJ
cord-341050-hnuogpqn	75	25	proteins	protein	NNS
cord-341050-hnuogpqn	75	26	on	on	IN
cord-341050-hnuogpqn	75	27	envelope	envelope	NN
cord-341050-hnuogpqn	75	28	membranes	membrane	NNS
cord-341050-hnuogpqn	75	29	[	[	-LRB-
cord-341050-hnuogpqn	75	30	142	142	CD
cord-341050-hnuogpqn	75	31	,	,	,
cord-341050-hnuogpqn	75	32	143	143	CD
cord-341050-hnuogpqn	75	33	]	]	-RRB-
cord-341050-hnuogpqn	75	34	.	.	.
cord-341050-hnuogpqn	76	1	Different	different	JJ
cord-341050-hnuogpqn	76	2	vectors	vector	NNS
cord-341050-hnuogpqn	76	3	and	and	CC
cord-341050-hnuogpqn	76	4	production	production	NN
cord-341050-hnuogpqn	76	5	system	system	NN
cord-341050-hnuogpqn	76	6	were	be	VBD
cord-341050-hnuogpqn	76	7	evaluated	evaluate	VBN
cord-341050-hnuogpqn	76	8	for	for	IN
cord-341050-hnuogpqn	76	9	development	development	NN
cord-341050-hnuogpqn	76	10	of	of	IN
cord-341050-hnuogpqn	76	11	various	various	JJ
cord-341050-hnuogpqn	76	12	subunit	subunit	NN
cord-341050-hnuogpqn	76	13	vaccines	vaccine	NNS
cord-341050-hnuogpqn	76	14	against	against	IN
cord-341050-hnuogpqn	76	15	WNV	WNV	NNP
cord-341050-hnuogpqn	76	16	.	.	.
cord-341050-hnuogpqn	77	1	For	for	IN
cord-341050-hnuogpqn	77	2	example	example	NN
cord-341050-hnuogpqn	77	3	,	,	,
cord-341050-hnuogpqn	77	4	a	a	DT
cord-341050-hnuogpqn	77	5	recombinant	recombinant	JJ
cord-341050-hnuogpqn	77	6	truncated	truncate	VBN
cord-341050-hnuogpqn	77	7	form	form	NN
cord-341050-hnuogpqn	77	8	of	of	IN
cord-341050-hnuogpqn	77	9	WNV	WNV	NNP
cord-341050-hnuogpqn	77	10	E	E	NNP
cord-341050-hnuogpqn	77	11	protein	protein	NN
cord-341050-hnuogpqn	77	12	produced	produce	VBN
cord-341050-hnuogpqn	77	13	in	in	IN
cord-341050-hnuogpqn	77	14	Escherichia	Escherichia	NNP
cord-341050-hnuogpqn	77	15	coli	coli	NNS
cord-341050-hnuogpqn	77	16	induced	induce	VBN
cord-341050-hnuogpqn	77	17	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	77	18	antibodies	antibody	NNS
cord-341050-hnuogpqn	77	19	and	and	CC
cord-341050-hnuogpqn	77	20	protected	protect	VBN
cord-341050-hnuogpqn	77	21	mice	mouse	NNS
cord-341050-hnuogpqn	77	22	from	from	IN
cord-341050-hnuogpqn	77	23	lethal	lethal	JJ
cord-341050-hnuogpqn	77	24	WNV	WNV	NNP
cord-341050-hnuogpqn	77	25	challenge	challenge	NN
cord-341050-hnuogpqn	77	26	[	[	-LRB-
cord-341050-hnuogpqn	77	27	46	46	CD
cord-341050-hnuogpqn	77	28	,	,	,
cord-341050-hnuogpqn	77	29	144	144	CD
cord-341050-hnuogpqn	77	30	]	]	-RRB-
cord-341050-hnuogpqn	77	31	.	.	.
cord-341050-hnuogpqn	78	1	In	in	IN
cord-341050-hnuogpqn	78	2	addition	addition	NN
cord-341050-hnuogpqn	78	3	,	,	,
cord-341050-hnuogpqn	78	4	a	a	DT
cord-341050-hnuogpqn	78	5	recombinant	recombinant	JJ
cord-341050-hnuogpqn	78	6	truncated	truncate	VBN
cord-341050-hnuogpqn	78	7	WNV	WNV	NNP
cord-341050-hnuogpqn	78	8	E	E	NNP
cord-341050-hnuogpqn	78	9	protein	protein	NN
cord-341050-hnuogpqn	78	10	produced	produce	VBN
cord-341050-hnuogpqn	78	11	in	in	IN
cord-341050-hnuogpqn	78	12	the	the	DT
cord-341050-hnuogpqn	78	13	SF+	SF+	NNP
cord-341050-hnuogpqn	78	14	insect	insect	NN
cord-341050-hnuogpqn	78	15	cells	cell	NNS
cord-341050-hnuogpqn	78	16	via	via	IN
cord-341050-hnuogpqn	78	17	baculovirus	baculovirus	NNP
cord-341050-hnuogpqn	78	18	infection	infection	NN
cord-341050-hnuogpqn	78	19	induced	induce	VBN
cord-341050-hnuogpqn	78	20	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	78	21	antibodies	antibody	NNS
cord-341050-hnuogpqn	78	22	and	and	CC
cord-341050-hnuogpqn	78	23	protected	protect	VBN
cord-341050-hnuogpqn	78	24	mice	mouse	NNS
cord-341050-hnuogpqn	78	25	and	and	CC
cord-341050-hnuogpqn	78	26	hamsters	hamster	NNS
cord-341050-hnuogpqn	78	27	from	from	IN
cord-341050-hnuogpqn	78	28	WNV	WNV	NNP
cord-341050-hnuogpqn	78	29	infection	infection	NN
cord-341050-hnuogpqn	78	30	[	[	-LRB-
cord-341050-hnuogpqn	78	31	145	145	CD
cord-341050-hnuogpqn	78	32	]	]	-RRB-
cord-341050-hnuogpqn	78	33	.	.	.
cord-341050-hnuogpqn	79	1	Recombinant	recombinant	JJ
cord-341050-hnuogpqn	79	2	baculovirus	baculovirus	NN
cord-341050-hnuogpqn	79	3	was	be	VBD
cord-341050-hnuogpqn	79	4	also	also	RB
cord-341050-hnuogpqn	79	5	used	use	VBN
cord-341050-hnuogpqn	79	6	to	to	TO
cord-341050-hnuogpqn	79	7	express	express	VB
cord-341050-hnuogpqn	79	8	WNV	WNV	NNP
cord-341050-hnuogpqn	79	9	prM	prm	JJ
cord-341050-hnuogpqn	79	10	and	and	CC
cord-341050-hnuogpqn	79	11	E	e	NN
cord-341050-hnuogpqn	79	12	proteins	protein	NNS
cord-341050-hnuogpqn	79	13	in	in	IN
cord-341050-hnuogpqn	79	14	mammalian	mammalian	JJ
cord-341050-hnuogpqn	79	15	cells	cell	NNS
cord-341050-hnuogpqn	79	16	under	under	IN
cord-341050-hnuogpqn	79	17	the	the	DT
cord-341050-hnuogpqn	79	18	CMV	CMV	NNP
cord-341050-hnuogpqn	79	19	promoter	promoter	NN
cord-341050-hnuogpqn	79	20	,	,	,
cord-341050-hnuogpqn	79	21	with	with	IN
cord-341050-hnuogpqn	79	22	or	or	CC
cord-341050-hnuogpqn	79	23	without	without	IN
cord-341050-hnuogpqn	79	24	vesicular	vesicular	JJ
cord-341050-hnuogpqn	79	25	stomatitis	stomatitis	NN
cord-341050-hnuogpqn	79	26	virus	virus	NN
cord-341050-hnuogpqn	79	27	glycoprotein	glycoprotein	NN
cord-341050-hnuogpqn	79	28	(	(	-LRB-
cord-341050-hnuogpqn	79	29	Bac	Bac	NNP
cord-341050-hnuogpqn	79	30	-	-	HYPH
cord-341050-hnuogpqn	79	31	G	G	NNP
cord-341050-hnuogpqn	79	32	-	-	HYPH
cord-341050-hnuogpqn	79	33	prM	prm	JJ
cord-341050-hnuogpqn	79	34	/	/	SYM
cord-341050-hnuogpqn	79	35	E	e	NN
cord-341050-hnuogpqn	79	36	)	)	-RRB-
cord-341050-hnuogpqn	79	37	.	.	.
cord-341050-hnuogpqn	80	1	Such	such	JJ
cord-341050-hnuogpqn	80	2	vaccines	vaccine	NNS
cord-341050-hnuogpqn	80	3	induced	induce	VBD
cord-341050-hnuogpqn	80	4	robust	robust	JJ
cord-341050-hnuogpqn	80	5	immune	immune	JJ
cord-341050-hnuogpqn	80	6	responses	response	NNS
cord-341050-hnuogpqn	80	7	when	when	WRB
cord-341050-hnuogpqn	80	8	inoculated	inoculate	VBN
cord-341050-hnuogpqn	80	9	in	in	IN
cord-341050-hnuogpqn	80	10	mice	mouse	NNS
cord-341050-hnuogpqn	80	11	and	and	CC
cord-341050-hnuogpqn	80	12	produced	produce	VBD
cord-341050-hnuogpqn	80	13	both	both	CC
cord-341050-hnuogpqn	80	14	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	80	15	antibodies	antibody	NNS
cord-341050-hnuogpqn	80	16	and	and	CC
cord-341050-hnuogpqn	80	17	infl	infl	NNP
cord-341050-hnuogpqn	80	18	ammatory	ammatory	NNP
cord-341050-hnuogpqn	80	19	cytokines	cytokine	NNS
cord-341050-hnuogpqn	80	20	[	[	-LRB-
cord-341050-hnuogpqn	80	21	146	146	CD
cord-341050-hnuogpqn	80	22	]	]	-RRB-
cord-341050-hnuogpqn	80	23	.	.	.
cord-341050-hnuogpqn	81	1	In	in	IN
cord-341050-hnuogpqn	81	2	a	a	DT
cord-341050-hnuogpqn	81	3	recently	recently	RB
cord-341050-hnuogpqn	81	4	proposed	propose	VBN
cord-341050-hnuogpqn	81	5	novel	novel	NN
cord-341050-hnuogpqn	81	6	approach	approach	NN
cord-341050-hnuogpqn	81	7	,	,	,
cord-341050-hnuogpqn	81	8	known	know	VBN
cord-341050-hnuogpqn	81	9	as	as	IN
cord-341050-hnuogpqn	81	10	pseudotyping	pseudotyping	NNP
cord-341050-hnuogpqn	81	11	,	,	,
cord-341050-hnuogpqn	81	12	a	a	DT
cord-341050-hnuogpqn	81	13	retrovirus	retrovirus	NN
cord-341050-hnuogpqn	81	14	Gag	Gag	NNP
cord-341050-hnuogpqn	81	15	polyprotein	polyprotein	NN
cord-341050-hnuogpqn	81	16	forms	form	VBZ
cord-341050-hnuogpqn	81	17	a	a	DT
cord-341050-hnuogpqn	81	18	VLP	VLP	NNP
cord-341050-hnuogpqn	81	19	scaffold	scaffold	NN
cord-341050-hnuogpqn	81	20	to	to	TO
cord-341050-hnuogpqn	81	21	display	display	VB
cord-341050-hnuogpqn	81	22	the	the	DT
cord-341050-hnuogpqn	81	23	ectodomain	ectodomain	NN
cord-341050-hnuogpqn	81	24	of	of	IN
cord-341050-hnuogpqn	81	25	human	human	JJ
cord-341050-hnuogpqn	81	26	membrane	membrane	NN
cord-341050-hnuogpqn	81	27	glycoprotein	glycoprotein	NN
cord-341050-hnuogpqn	81	28	(	(	-LRB-
cord-341050-hnuogpqn	81	29	CD16	CD16	NNP
cord-341050-hnuogpqn	81	30	)	)	-RRB-
cord-341050-hnuogpqn	81	31	that	that	WDT
cord-341050-hnuogpqn	81	32	was	be	VBD
cord-341050-hnuogpqn	81	33	fused	fuse	VBN
cord-341050-hnuogpqn	81	34	to	to	IN
cord-341050-hnuogpqn	81	35	the	the	DT
cord-341050-hnuogpqn	81	36	high	high	JJ
cord-341050-hnuogpqn	81	37	affi	affi	NNP
cord-341050-hnuogpqn	81	38	nity	nity	NNP
cord-341050-hnuogpqn	81	39	IgE	IgE	NNP
cord-341050-hnuogpqn	81	40	receptor	receptor	NNP
cord-341050-hnuogpqn	81	41	gamma	gamma	NN
cord-341050-hnuogpqn	81	42	chain	chain	NN
cord-341050-hnuogpqn	81	43	(	(	-LRB-
cord-341050-hnuogpqn	81	44	RIgE	RIgE	NNS
cord-341050-hnuogpqn	81	45	)	)	-RRB-
cord-341050-hnuogpqn	81	46	.	.	.
cord-341050-hnuogpqn	82	1	Using	use	VBG
cord-341050-hnuogpqn	82	2	this	this	DT
cord-341050-hnuogpqn	82	3	retrovirus	retrovirus	NN
cord-341050-hnuogpqn	82	4	based	base	VBN
cord-341050-hnuogpqn	82	5	VLPs	VLPs	NNP
cord-341050-hnuogpqn	82	6	platform	platform	NN
cord-341050-hnuogpqn	82	7	,	,	,
cord-341050-hnuogpqn	82	8	a	a	DT
cord-341050-hnuogpqn	82	9	WNV	WNV	NNP
cord-341050-hnuogpqn	82	10	vaccine	vaccine	NN
cord-341050-hnuogpqn	82	11	was	be	VBD
cord-341050-hnuogpqn	82	12	generated	generate	VBN
cord-341050-hnuogpqn	82	13	by	by	IN
cord-341050-hnuogpqn	82	14	replacement	replacement	NN
cord-341050-hnuogpqn	82	15	of	of	IN
cord-341050-hnuogpqn	82	16	the	the	DT
cord-341050-hnuogpqn	82	17	CD16	CD16	NNP
cord-341050-hnuogpqn	82	18	ectodomain	ectodomain	NN
cord-341050-hnuogpqn	82	19	in	in	IN
cord-341050-hnuogpqn	82	20	CD16-RIgE	CD16-RIgE	,
cord-341050-hnuogpqn	82	21	glycoprotein	glycoprotein	NN
cord-341050-hnuogpqn	82	22	with	with	IN
cord-341050-hnuogpqn	82	23	EDIII	EDIII	NNP
cord-341050-hnuogpqn	82	24	of	of	IN
cord-341050-hnuogpqn	82	25	WNV	WNV	NNP
cord-341050-hnuogpqn	82	26	,	,	,
cord-341050-hnuogpqn	82	27	which	which	WDT
cord-341050-hnuogpqn	82	28	induced	induce	VBD
cord-341050-hnuogpqn	82	29	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	82	30	antibodies	antibody	NNS
cord-341050-hnuogpqn	82	31	in	in	IN
cord-341050-hnuogpqn	82	32	mice	mouse	NNS
cord-341050-hnuogpqn	82	33	[	[	-LRB-
cord-341050-hnuogpqn	82	34	139	139	CD
cord-341050-hnuogpqn	82	35	]	]	-RRB-
cord-341050-hnuogpqn	82	36	.	.	.
cord-341050-hnuogpqn	83	1	A	a	DT
cord-341050-hnuogpqn	83	2	recombinant	recombinant	JJ
cord-341050-hnuogpqn	83	3	E	e	NN
cord-341050-hnuogpqn	83	4	protein	protein	NN
cord-341050-hnuogpqn	83	5	of	of	IN
cord-341050-hnuogpqn	83	6	WNV	WNV	NNP
cord-341050-hnuogpqn	83	7	-	-	HYPH
cord-341050-hnuogpqn	83	8	NY99	NY99	NNP
cord-341050-hnuogpqn	83	9	produced	produce	VBD
cord-341050-hnuogpqn	83	10	in	in	IN
cord-341050-hnuogpqn	83	11	Drosophila	Drosophila	NNP
cord-341050-hnuogpqn	83	12	S2	S2	NNP
cord-341050-hnuogpqn	83	13	cells	cell	NNS
cord-341050-hnuogpqn	83	14	(	(	-LRB-
cord-341050-hnuogpqn	83	15	WNV-80E	wnv-80e	NN
cord-341050-hnuogpqn	83	16	,	,	,
cord-341050-hnuogpqn	83	17	developed	develop	VBN
cord-341050-hnuogpqn	83	18	by	by	IN
cord-341050-hnuogpqn	83	19	Hawaii	Hawaii	NNP
cord-341050-hnuogpqn	83	20	Biotech	Biotech	NNP
cord-341050-hnuogpqn	83	21	)	)	-RRB-
cord-341050-hnuogpqn	83	22	is	be	VBZ
cord-341050-hnuogpqn	83	23	the	the	DT
cord-341050-hnuogpqn	83	24	only	only	JJ
cord-341050-hnuogpqn	83	25	WNV	WNV	NNP
cord-341050-hnuogpqn	83	26	subunit	subunit	NN
cord-341050-hnuogpqn	83	27	vaccine	vaccine	NN
cord-341050-hnuogpqn	83	28	candidate	candidate	NN
cord-341050-hnuogpqn	83	29	that	that	WDT
cord-341050-hnuogpqn	83	30	has	have	VBZ
cord-341050-hnuogpqn	83	31	been	be	VBN
cord-341050-hnuogpqn	83	32	tested	test	VBN
cord-341050-hnuogpqn	83	33	in	in	IN
cord-341050-hnuogpqn	83	34	phase	phase	NN
cord-341050-hnuogpqn	83	35	I	-PRON-	PRP
cord-341050-hnuogpqn	83	36	clinical	clinical	JJ
cord-341050-hnuogpqn	83	37	trial	trial	NN
cord-341050-hnuogpqn	83	38	.	.	.
cord-341050-hnuogpqn	84	1	Although	although	IN
cord-341050-hnuogpqn	84	2	preclinical	preclinical	JJ
cord-341050-hnuogpqn	84	3	studies	study	NNS
cord-341050-hnuogpqn	84	4	revealed	reveal	VBD
cord-341050-hnuogpqn	84	5	WNVspecifi	WNVspecifi	NNP
cord-341050-hnuogpqn	84	6	c	c	NN
cord-341050-hnuogpqn	84	7	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	84	8	antibody	antibody	NN
cord-341050-hnuogpqn	84	9	responses	response	NNS
cord-341050-hnuogpqn	84	10	in	in	IN
cord-341050-hnuogpqn	84	11	vaccinated	vaccinated	JJ
cord-341050-hnuogpqn	84	12	animals	animal	NNS
cord-341050-hnuogpqn	84	13	[	[	-LRB-
cord-341050-hnuogpqn	84	14	136	136	CD
cord-341050-hnuogpqn	84	15	,	,	,
cord-341050-hnuogpqn	84	16	147	147	CD
cord-341050-hnuogpqn	84	17	,	,	,
cord-341050-hnuogpqn	84	18	148	148	CD
cord-341050-hnuogpqn	84	19	]	]	-RRB-
cord-341050-hnuogpqn	84	20	,	,	,
cord-341050-hnuogpqn	84	21	the	the	DT
cord-341050-hnuogpqn	84	22	immunogenicity	immunogenicity	NN
cord-341050-hnuogpqn	84	23	of	of	IN
cord-341050-hnuogpqn	84	24	this	this	DT
cord-341050-hnuogpqn	84	25	vaccine	vaccine	NN
cord-341050-hnuogpqn	84	26	in	in	IN
cord-341050-hnuogpqn	84	27	humans	human	NNS
cord-341050-hnuogpqn	84	28	was	be	VBD
cord-341050-hnuogpqn	84	29	low	low	JJ
cord-341050-hnuogpqn	84	30	.	.	.
cord-341050-hnuogpqn	85	1	To	to	TO
cord-341050-hnuogpqn	85	2	increase	increase	VB
cord-341050-hnuogpqn	85	3	immunogenicity	immunogenicity	NN
cord-341050-hnuogpqn	85	4	,	,	,
cord-341050-hnuogpqn	85	5	conjugation	conjugation	NN
cord-341050-hnuogpqn	85	6	of	of	IN
cord-341050-hnuogpqn	85	7	recombinant	recombinant	JJ
cord-341050-hnuogpqn	85	8	proteins	protein	NNS
cord-341050-hnuogpqn	85	9	with	with	IN
cord-341050-hnuogpqn	85	10	nanoparticles	nanoparticle	NNS
cord-341050-hnuogpqn	85	11	or	or	CC
cord-341050-hnuogpqn	85	12	pathogen	pathogen	NN
cord-341050-hnuogpqn	85	13	associated	associate	VBD
cord-341050-hnuogpqn	85	14	molecular	molecular	JJ
cord-341050-hnuogpqn	85	15	patterns	pattern	NNS
cord-341050-hnuogpqn	85	16	(	(	-LRB-
cord-341050-hnuogpqn	85	17	PAMPs	pamp	NNS
cord-341050-hnuogpqn	85	18	)	)	-RRB-
cord-341050-hnuogpqn	85	19	as	as	IN
cord-341050-hnuogpqn	85	20	carrier	carrier	NN
cord-341050-hnuogpqn	85	21	/	/	SYM
cord-341050-hnuogpqn	85	22	adjuvant	adjuvant	NN
cord-341050-hnuogpqn	85	23	have	have	VBP
cord-341050-hnuogpqn	85	24	been	be	VBN
cord-341050-hnuogpqn	85	25	tested	test	VBN
cord-341050-hnuogpqn	85	26	.	.	.
cord-341050-hnuogpqn	86	1	For	for	IN
cord-341050-hnuogpqn	86	2	instance	instance	NN
cord-341050-hnuogpqn	86	3	,	,	,
cord-341050-hnuogpqn	86	4	a	a	DT
cord-341050-hnuogpqn	86	5	recombinant	recombinant	JJ
cord-341050-hnuogpqn	86	6	WNV	WNV	NNP
cord-341050-hnuogpqn	86	7	E	E	NNP
cord-341050-hnuogpqn	86	8	protein	protein	NN
cord-341050-hnuogpqn	86	9	administered	administer	VBN
cord-341050-hnuogpqn	86	10	with	with	IN
cord-341050-hnuogpqn	86	11	unmethylated	unmethylate	VBN
cord-341050-hnuogpqn	86	12	CpG	CpG	NNP
cord-341050-hnuogpqn	86	13	oligonucleotide	oligonucleotide	NNP
cord-341050-hnuogpqn	86	14	adjuvant	adjuvant	NNP
cord-341050-hnuogpqn	86	15	or	or	CC
cord-341050-hnuogpqn	86	16	loaded	load	VBN
cord-341050-hnuogpqn	86	17	onto	onto	IN
cord-341050-hnuogpqn	86	18	CpG	CpG	NNP
cord-341050-hnuogpqn	86	19	-	-	HYPH
cord-341050-hnuogpqn	86	20	modifi	modifi	NNP
cord-341050-hnuogpqn	86	21	ed	ed	NN
cord-341050-hnuogpqn	86	22	nanoparticles	nanoparticle	NNS
cord-341050-hnuogpqn	86	23	strongly	strongly	RB
cord-341050-hnuogpqn	86	24	activated	activate	VBN
cord-341050-hnuogpqn	86	25	dendritic	dendritic	JJ
cord-341050-hnuogpqn	86	26	cells	cell	NNS
cord-341050-hnuogpqn	86	27	and	and	CC
cord-341050-hnuogpqn	86	28	lymphocytes	lymphocyte	NNS
cord-341050-hnuogpqn	86	29	and	and	CC
cord-341050-hnuogpqn	86	30	elicited	elicit	VBD
cord-341050-hnuogpqn	86	31	Th1-dominant	Th1-dominant	NNP
cord-341050-hnuogpqn	86	32	immune	immune	JJ
cord-341050-hnuogpqn	86	33	responses	response	NNS
cord-341050-hnuogpqn	86	34	by	by	IN
cord-341050-hnuogpqn	86	35	producing	produce	VBG
cord-341050-hnuogpqn	86	36	high	high	JJ
cord-341050-hnuogpqn	86	37	titers	titer	NNS
cord-341050-hnuogpqn	86	38	of	of	IN
cord-341050-hnuogpqn	86	39	IgG2a	IgG2a	NNP
cord-341050-hnuogpqn	86	40	and	and	CC
cord-341050-hnuogpqn	86	41	IgG2b	IgG2b	NNP
cord-341050-hnuogpqn	86	42	in	in	IN
cord-341050-hnuogpqn	86	43	immunized	immunized	JJ
cord-341050-hnuogpqn	86	44	mice	mouse	NNS
cord-341050-hnuogpqn	86	45	[	[	-LRB-
cord-341050-hnuogpqn	86	46	149	149	CD
cord-341050-hnuogpqn	86	47	,	,	,
cord-341050-hnuogpqn	86	48	150	150	CD
cord-341050-hnuogpqn	86	49	]	]	-RRB-
cord-341050-hnuogpqn	86	50	.	.	.
cord-341050-hnuogpqn	87	1	Similarly	similarly	RB
cord-341050-hnuogpqn	87	2	,	,	,
cord-341050-hnuogpqn	87	3	mice	mouse	NNS
cord-341050-hnuogpqn	87	4	injected	inject	VBN
cord-341050-hnuogpqn	87	5	with	with	IN
cord-341050-hnuogpqn	87	6	DIII	DIII	NNP
cord-341050-hnuogpqn	87	7	of	of	IN
cord-341050-hnuogpqn	87	8	WNV	WNV	NNP
cord-341050-hnuogpqn	87	9	E	E	NNP
cord-341050-hnuogpqn	87	10	conjugated	conjugate	VBN
cord-341050-hnuogpqn	87	11	with	with	IN
cord-341050-hnuogpqn	87	12	bacterial	bacterial	JJ
cord-341050-hnuogpqn	87	13	fl	fl	NNP
cord-341050-hnuogpqn	87	14	agellin	agellin	NNP
cord-341050-hnuogpqn	87	15	(	(	-LRB-
cord-341050-hnuogpqn	87	16	STF2∆.EIII	STF2∆.EIII	NNP
cord-341050-hnuogpqn	87	17	)	)	-RRB-
cord-341050-hnuogpqn	87	18	[	[	-LRB-
cord-341050-hnuogpqn	87	19	137	137	CD
cord-341050-hnuogpqn	87	20	]	]	-RRB-
cord-341050-hnuogpqn	87	21	or	or	CC
cord-341050-hnuogpqn	87	22	VLP	VLP	NNP
cord-341050-hnuogpqn	87	23	derived	derive	VBN
cord-341050-hnuogpqn	87	24	from	from	IN
cord-341050-hnuogpqn	87	25	bacteriophage	bacteriophage	NN
cord-341050-hnuogpqn	87	26	AP205	AP205	NNP
cord-341050-hnuogpqn	87	27	engineered	engineer	VBN
cord-341050-hnuogpqn	87	28	to	to	TO
cord-341050-hnuogpqn	87	29	express	express	VB
cord-341050-hnuogpqn	87	30	DIII	DIII	NNP
cord-341050-hnuogpqn	87	31	of	of	IN
cord-341050-hnuogpqn	87	32	WNV	WNV	NNP
cord-341050-hnuogpqn	87	33	E	E	NNP
cord-341050-hnuogpqn	87	34	(	(	-LRB-
cord-341050-hnuogpqn	87	35	DIII	DIII	NNP
cord-341050-hnuogpqn	87	36	-	-	HYPH
cord-341050-hnuogpqn	87	37	C	C	NNP
cord-341050-hnuogpqn	87	38	-	-	HYPH
cord-341050-hnuogpqn	87	39	AP205	AP205	NNP
cord-341050-hnuogpqn	87	40	)	)	-RRB-
cord-341050-hnuogpqn	88	1	[	[	-LRB-
cord-341050-hnuogpqn	88	2	138	138	CD
cord-341050-hnuogpqn	88	3	]	]	-RRB-
cord-341050-hnuogpqn	88	4	also	also	RB
cord-341050-hnuogpqn	88	5	signifi	signifi	NNP
cord-341050-hnuogpqn	88	6	cantly	cantly	RB
cord-341050-hnuogpqn	88	7	increased	increase	VBD
cord-341050-hnuogpqn	88	8	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	88	9	antibody	antibody	NN
cord-341050-hnuogpqn	88	10	production	production	NN
cord-341050-hnuogpqn	88	11	and	and	CC
cord-341050-hnuogpqn	88	12	protected	protect	VBD
cord-341050-hnuogpqn	88	13	the	the	DT
cord-341050-hnuogpqn	88	14	immunized	immunize	VBN
cord-341050-hnuogpqn	88	15	mice	mouse	NNS
cord-341050-hnuogpqn	88	16	.	.	.
cord-341050-hnuogpqn	89	1	Despite	despite	IN
cord-341050-hnuogpqn	89	2	the	the	DT
cord-341050-hnuogpqn	89	3	intensive	intensive	JJ
cord-341050-hnuogpqn	89	4	efforts	effort	NNS
cord-341050-hnuogpqn	89	5	in	in	IN
cord-341050-hnuogpqn	89	6	development	development	NN
cord-341050-hnuogpqn	89	7	of	of	IN
cord-341050-hnuogpqn	89	8	WNV	WNV	NNP
cord-341050-hnuogpqn	89	9	vaccines	vaccine	NNS
cord-341050-hnuogpqn	89	10	,	,	,
cord-341050-hnuogpqn	89	11	only	only	RB
cord-341050-hnuogpqn	89	12	a	a	DT
cord-341050-hnuogpqn	89	13	few	few	JJ
cord-341050-hnuogpqn	89	14	reached	reach	VBD
cord-341050-hnuogpqn	89	15	the	the	DT
cord-341050-hnuogpqn	89	16	clinical	clinical	JJ
cord-341050-hnuogpqn	89	17	trial	trial	NN
cord-341050-hnuogpqn	89	18	stages	stage	NNS
cord-341050-hnuogpqn	89	19	.	.	.
cord-341050-hnuogpqn	90	1	Of	of	IN
cord-341050-hnuogpqn	90	2	those	those	DT
cord-341050-hnuogpqn	90	3	in	in	IN
cord-341050-hnuogpqn	90	4	clinical	clinical	JJ
cord-341050-hnuogpqn	90	5	trials	trial	NNS
cord-341050-hnuogpqn	90	6	,	,	,
cord-341050-hnuogpqn	90	7	most	most	JJS
cord-341050-hnuogpqn	90	8	candidate	candidate	NN
cord-341050-hnuogpqn	90	9	vaccines	vaccine	NNS
cord-341050-hnuogpqn	90	10	fail	fail	VBP
cord-341050-hnuogpqn	90	11	to	to	TO
cord-341050-hnuogpqn	90	12	demonstrate	demonstrate	VB
cord-341050-hnuogpqn	90	13	effi	effi	NNP
cord-341050-hnuogpqn	90	14	cient	cient	NN
cord-341050-hnuogpqn	90	15	immunity	immunity	NN
cord-341050-hnuogpqn	90	16	and	and	CC
cord-341050-hnuogpqn	90	17	safety	safety	NN
cord-341050-hnuogpqn	90	18	.	.	.
cord-341050-hnuogpqn	91	1	Development	development	NN
cord-341050-hnuogpqn	91	2	of	of	IN
cord-341050-hnuogpqn	91	3	new	new	JJ
cord-341050-hnuogpqn	91	4	tools	tool	NNS
cord-341050-hnuogpqn	91	5	for	for	IN
cord-341050-hnuogpqn	91	6	antigen	antigen	NN
cord-341050-hnuogpqn	91	7	screening	screening	NN
cord-341050-hnuogpqn	91	8	,	,	,
cord-341050-hnuogpqn	91	9	expanded	expand	VBD
cord-341050-hnuogpqn	91	10	understanding	understanding	NN
cord-341050-hnuogpqn	91	11	of	of	IN
cord-341050-hnuogpqn	91	12	immunological	immunological	JJ
cord-341050-hnuogpqn	91	13	correlates	correlate	NNS
cord-341050-hnuogpqn	91	14	of	of	IN
cord-341050-hnuogpqn	91	15	vaccine	vaccine	NN
cord-341050-hnuogpqn	91	16	inducedimmunity	inducedimmunity	NN
cord-341050-hnuogpqn	91	17	,	,	,
cord-341050-hnuogpqn	91	18	and	and	CC
cord-341050-hnuogpqn	91	19	discovery	discovery	NN
cord-341050-hnuogpqn	91	20	of	of	IN
cord-341050-hnuogpqn	91	21	novel	novel	JJ
cord-341050-hnuogpqn	91	22	adjuvants	adjuvant	NNS
cord-341050-hnuogpqn	91	23	for	for	IN
cord-341050-hnuogpqn	91	24	vaccine	vaccine	NN
cord-341050-hnuogpqn	91	25	delivery	delivery	NN
cord-341050-hnuogpqn	91	26	may	may	MD
cord-341050-hnuogpqn	91	27	facilitate	facilitate	VB
cord-341050-hnuogpqn	91	28	the	the	DT
cord-341050-hnuogpqn	91	29	design	design	NN
cord-341050-hnuogpqn	91	30	and	and	CC
cord-341050-hnuogpqn	91	31	the	the	DT
cord-341050-hnuogpqn	91	32	development	development	NN
cord-341050-hnuogpqn	91	33	of	of	IN
cord-341050-hnuogpqn	91	34	WNV	WNV	NNP
cord-341050-hnuogpqn	91	35	vaccines	vaccine	NNS
cord-341050-hnuogpqn	91	36	.	.	.
cord-341050-hnuogpqn	92	1	For	for	IN
cord-341050-hnuogpqn	92	2	example	example	NN
cord-341050-hnuogpqn	92	3	,	,	,
cord-341050-hnuogpqn	92	4	knowledge	knowledge	NN
cord-341050-hnuogpqn	92	5	of	of	IN
cord-341050-hnuogpqn	92	6	genomic	genomic	JJ
cord-341050-hnuogpqn	92	7	information	information	NN
cord-341050-hnuogpqn	92	8	and	and	CC
cord-341050-hnuogpqn	92	9	bioinformatics	bioinformatics	NN
cord-341050-hnuogpqn	92	10	has	have	VBZ
cord-341050-hnuogpqn	92	11	been	be	VBN
cord-341050-hnuogpqn	92	12	used	use	VBN
cord-341050-hnuogpqn	92	13	for	for	IN
cord-341050-hnuogpqn	92	14	in	in	IN
cord-341050-hnuogpqn	92	15	silico	silico	NNP
cord-341050-hnuogpqn	92	16	identifi	identifi	NNP
cord-341050-hnuogpqn	92	17	cation	cation	NNP
cord-341050-hnuogpqn	92	18	of	of	IN
cord-341050-hnuogpqn	92	19	candidate	candidate	NN
cord-341050-hnuogpqn	92	20	antigens	antigen	NNS
cord-341050-hnuogpqn	92	21	and	and	CC
cord-341050-hnuogpqn	92	22	development	development	NN
cord-341050-hnuogpqn	92	23	of	of	IN
cord-341050-hnuogpqn	92	24	vaccines	vaccine	NNS
cord-341050-hnuogpqn	92	25	by	by	IN
cord-341050-hnuogpqn	92	26	a	a	DT
cord-341050-hnuogpqn	92	27	novel	novel	JJ
cord-341050-hnuogpqn	92	28	method	method	NN
cord-341050-hnuogpqn	92	29	called	call	VBN
cord-341050-hnuogpqn	92	30	"	"	``
cord-341050-hnuogpqn	92	31	reverse	reverse	JJ
cord-341050-hnuogpqn	92	32	vaccinology	vaccinology	NN
cord-341050-hnuogpqn	92	33	"	"	''
cord-341050-hnuogpqn	92	34	[	[	-LRB-
cord-341050-hnuogpqn	92	35	151	151	CD
cord-341050-hnuogpqn	92	36	,	,	,
cord-341050-hnuogpqn	92	37	152	152	CD
cord-341050-hnuogpqn	92	38	]	]	-RRB-
cord-341050-hnuogpqn	92	39	.	.	.
cord-341050-hnuogpqn	93	1	This	this	DT
cord-341050-hnuogpqn	93	2	comprehensive	comprehensive	JJ
cord-341050-hnuogpqn	93	3	tool	tool	NN
cord-341050-hnuogpqn	93	4	can	can	MD
cord-341050-hnuogpqn	93	5	quickly	quickly	RB
cord-341050-hnuogpqn	93	6	identify	identify	VB
cord-341050-hnuogpqn	93	7	all	all	DT
cord-341050-hnuogpqn	93	8	potential	potential	JJ
cord-341050-hnuogpqn	93	9	antigens	antigen	NNS
cord-341050-hnuogpqn	93	10	coded	code	VBN
cord-341050-hnuogpqn	93	11	in	in	IN
cord-341050-hnuogpqn	93	12	the	the	DT
cord-341050-hnuogpqn	93	13	genome	genome	NN
cord-341050-hnuogpqn	93	14	and	and	CC
cord-341050-hnuogpqn	93	15	may	may	MD
cord-341050-hnuogpqn	93	16	be	be	VB
cord-341050-hnuogpqn	93	17	used	use	VBN
cord-341050-hnuogpqn	93	18	to	to	TO
cord-341050-hnuogpqn	93	19	develop	develop	VB
cord-341050-hnuogpqn	93	20	a	a	DT
cord-341050-hnuogpqn	93	21	novel	novel	JJ
cord-341050-hnuogpqn	93	22	viral	viral	JJ
cord-341050-hnuogpqn	93	23	vaccine	vaccine	NN
cord-341050-hnuogpqn	93	24	[	[	-LRB-
cord-341050-hnuogpqn	93	25	153	153	CD
cord-341050-hnuogpqn	93	26	]	]	-RRB-
cord-341050-hnuogpqn	93	27	.	.	.
cord-341050-hnuogpqn	94	1	Development	development	NN
cord-341050-hnuogpqn	94	2	of	of	IN
cord-341050-hnuogpqn	94	3	vaccine	vaccine	NN
cord-341050-hnuogpqn	94	4	against	against	IN
cord-341050-hnuogpqn	94	5	group	group	NN
cord-341050-hnuogpqn	94	6	B	b	NN
cord-341050-hnuogpqn	94	7	streptococci	streptococcus	NNS
cord-341050-hnuogpqn	94	8	proved	prove	VBD
cord-341050-hnuogpqn	94	9	the	the	DT
cord-341050-hnuogpqn	94	10	potential	potential	NN
cord-341050-hnuogpqn	94	11	of	of	IN
cord-341050-hnuogpqn	94	12	this	this	DT
cord-341050-hnuogpqn	94	13	approach	approach	NN
cord-341050-hnuogpqn	94	14	[	[	-LRB-
cord-341050-hnuogpqn	94	15	151	151	CD
cord-341050-hnuogpqn	94	16	]	]	-RRB-
cord-341050-hnuogpqn	94	17	.	.	.
cord-341050-hnuogpqn	95	1	Similarly	similarly	RB
cord-341050-hnuogpqn	95	2	,	,	,
cord-341050-hnuogpqn	95	3	a	a	DT
cord-341050-hnuogpqn	95	4	"	"	``
cord-341050-hnuogpqn	95	5	structural	structural	JJ
cord-341050-hnuogpqn	95	6	approach	approach	NN
cord-341050-hnuogpqn	95	7	"	"	''
cord-341050-hnuogpqn	95	8	that	that	WDT
cord-341050-hnuogpqn	95	9	improves	improve	VBZ
cord-341050-hnuogpqn	95	10	antigenicity	antigenicity	NN
cord-341050-hnuogpqn	95	11	of	of	IN
cord-341050-hnuogpqn	95	12	vaccines	vaccine	NNS
cord-341050-hnuogpqn	95	13	by	by	IN
cord-341050-hnuogpqn	95	14	rational	rational	JJ
cord-341050-hnuogpqn	95	15	designing	designing	NN
cord-341050-hnuogpqn	95	16	has	have	VBZ
cord-341050-hnuogpqn	95	17	been	be	VBN
cord-341050-hnuogpqn	95	18	developed	develop	VBN
cord-341050-hnuogpqn	95	19	by	by	IN
cord-341050-hnuogpqn	95	20	utilizing	utilize	VBG
cord-341050-hnuogpqn	95	21	the	the	DT
cord-341050-hnuogpqn	95	22	knowledge	knowledge	NN
cord-341050-hnuogpqn	95	23	of	of	IN
cord-341050-hnuogpqn	95	24	immunology	immunology	NN
cord-341050-hnuogpqn	95	25	,	,	,
cord-341050-hnuogpqn	95	26	structural	structural	JJ
cord-341050-hnuogpqn	95	27	biology	biology	NN
cord-341050-hnuogpqn	95	28	,	,	,
cord-341050-hnuogpqn	95	29	and	and	CC
cord-341050-hnuogpqn	95	30	bioinformatics	bioinformatic	NNS
cord-341050-hnuogpqn	95	31	[	[	-LRB-
cord-341050-hnuogpqn	95	32	154	154	CD
cord-341050-hnuogpqn	95	33	]	]	-RRB-
cord-341050-hnuogpqn	95	34	.	.	.
cord-341050-hnuogpqn	96	1	In	in	IN
cord-341050-hnuogpqn	96	2	addition	addition	NN
cord-341050-hnuogpqn	96	3	,	,	,
cord-341050-hnuogpqn	96	4	increased	increase	VBN
cord-341050-hnuogpqn	96	5	understanding	understanding	NN
cord-341050-hnuogpqn	96	6	of	of	IN
cord-341050-hnuogpqn	96	7	immunogenetics	immunogenetic	NNS
cord-341050-hnuogpqn	96	8	and	and	CC
cord-341050-hnuogpqn	96	9	role	role	NN
cord-341050-hnuogpqn	96	10	of	of	IN
cord-341050-hnuogpqn	96	11	environmental	environmental	JJ
cord-341050-hnuogpqn	96	12	and	and	CC
cord-341050-hnuogpqn	96	13	host	host	NN
cord-341050-hnuogpqn	96	14	factors	factor	NNS
cord-341050-hnuogpqn	96	15	that	that	WDT
cord-341050-hnuogpqn	96	16	determine	determine	VBP
cord-341050-hnuogpqn	96	17	the	the	DT
cord-341050-hnuogpqn	96	18	variation	variation	NN
cord-341050-hnuogpqn	96	19	of	of	IN
cord-341050-hnuogpqn	96	20	vaccine	vaccine	NN
cord-341050-hnuogpqn	96	21	immunity	immunity	NN
cord-341050-hnuogpqn	96	22	may	may	MD
cord-341050-hnuogpqn	96	23	offer	offer	VB
cord-341050-hnuogpqn	96	24	new	new	JJ
cord-341050-hnuogpqn	96	25	approaches	approach	NNS
cord-341050-hnuogpqn	96	26	to	to	TO
cord-341050-hnuogpqn	96	27	design	design	VB
cord-341050-hnuogpqn	96	28	a	a	DT
cord-341050-hnuogpqn	96	29	more	more	RBR
cord-341050-hnuogpqn	96	30	effective	effective	JJ
cord-341050-hnuogpqn	96	31	vaccine	vaccine	NN
cord-341050-hnuogpqn	96	32	against	against	IN
cord-341050-hnuogpqn	96	33	WNV	WNV	NNP
cord-341050-hnuogpqn	96	34	infection	infection	NN
cord-341050-hnuogpqn	96	35	in	in	IN
cord-341050-hnuogpqn	96	36	humans	human	NNS
cord-341050-hnuogpqn	96	37	.	.	.
cord-341050-hnuogpqn	97	1	Therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	97	2	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	97	3	antibodies	antibody	NNS
cord-341050-hnuogpqn	97	4	(	(	-LRB-
cord-341050-hnuogpqn	97	5	mAbs	mAbs	NNP
cord-341050-hnuogpqn	97	6	)	)	-RRB-
cord-341050-hnuogpqn	97	7	or	or	CC
cord-341050-hnuogpqn	97	8	hyperimmune	hyperimmune	NNP
cord-341050-hnuogpqn	97	9	sera	sera	NNP
cord-341050-hnuogpqn	97	10	have	have	VBP
cord-341050-hnuogpqn	97	11	been	be	VBN
cord-341050-hnuogpqn	97	12	successfully	successfully	RB
cord-341050-hnuogpqn	97	13	used	use	VBN
cord-341050-hnuogpqn	97	14	for	for	IN
cord-341050-hnuogpqn	97	15	prophylaxis	prophylaxis	NN
cord-341050-hnuogpqn	97	16	of	of	IN
cord-341050-hnuogpqn	97	17	a	a	DT
cord-341050-hnuogpqn	97	18	number	number	NN
cord-341050-hnuogpqn	97	19	of	of	IN
cord-341050-hnuogpqn	97	20	infectious	infectious	JJ
cord-341050-hnuogpqn	97	21	and	and	CC
cord-341050-hnuogpqn	97	22	noninfectious	noninfectious	JJ
cord-341050-hnuogpqn	97	23	diseases	disease	NNS
cord-341050-hnuogpqn	97	24	,	,	,
cord-341050-hnuogpqn	97	25	including	include	VBG
cord-341050-hnuogpqn	97	26	WNV	WNV	NNP
cord-341050-hnuogpqn	97	27	infection	infection	NN
cord-341050-hnuogpqn	97	28	.	.	.
cord-341050-hnuogpqn	98	1	In	in	IN
cord-341050-hnuogpqn	98	2	recent	recent	JJ
cord-341050-hnuogpqn	98	3	years	year	NNS
cord-341050-hnuogpqn	98	4	,	,	,
cord-341050-hnuogpqn	98	5	the	the	DT
cord-341050-hnuogpqn	98	6	number	number	NN
cord-341050-hnuogpqn	98	7	of	of	IN
cord-341050-hnuogpqn	98	8	mAbs	mAbs	NNP
cord-341050-hnuogpqn	98	9	in	in	IN
cord-341050-hnuogpqn	98	10	preclinical	preclinical	JJ
cord-341050-hnuogpqn	98	11	development	development	NN
cord-341050-hnuogpqn	98	12	and	and	CC
cord-341050-hnuogpqn	98	13	clinical	clinical	JJ
cord-341050-hnuogpqn	98	14	trials	trial	NNS
cord-341050-hnuogpqn	98	15	has	have	VBZ
cord-341050-hnuogpqn	98	16	been	be	VBN
cord-341050-hnuogpqn	98	17	increased	increase	VBN
cord-341050-hnuogpqn	98	18	signifi	signifi	NNP
cord-341050-hnuogpqn	98	19	cantly	cantly	NNP
cord-341050-hnuogpqn	98	20	[	[	-LRB-
cord-341050-hnuogpqn	98	21	155	155	CD
cord-341050-hnuogpqn	98	22	]	]	-RRB-
cord-341050-hnuogpqn	98	23	.	.	.
cord-341050-hnuogpqn	99	1	So	so	RB
cord-341050-hnuogpqn	99	2	far	far	RB
cord-341050-hnuogpqn	99	3	,	,	,
cord-341050-hnuogpqn	99	4	nearly	nearly	RB
cord-341050-hnuogpqn	99	5	50	50	CD
cord-341050-hnuogpqn	99	6	mAbs	mAbs	NNP
cord-341050-hnuogpqn	99	7	have	have	VBP
cord-341050-hnuogpqn	99	8	been	be	VBN
cord-341050-hnuogpqn	99	9	approved	approve	VBN
cord-341050-hnuogpqn	99	10	for	for	IN
cord-341050-hnuogpqn	99	11	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	99	12	by	by	IN
cord-341050-hnuogpqn	99	13	US	US	NNP
cord-341050-hnuogpqn	99	14	FDA	FDA	NNP
cord-341050-hnuogpqn	99	15	,	,	,
cord-341050-hnuogpqn	99	16	including	include	VBG
cord-341050-hnuogpqn	99	17	a	a	DT
cord-341050-hnuogpqn	99	18	humanized	humanize	VBN
cord-341050-hnuogpqn	99	19	mAb	mAb	NNP
cord-341050-hnuogpqn	99	20	Synagis	Synagis	NNP
cord-341050-hnuogpqn	99	21	(	(	-LRB-
cord-341050-hnuogpqn	99	22	palivizumab	palivizumab	NNP
cord-341050-hnuogpqn	99	23	)	)	-RRB-
cord-341050-hnuogpqn	99	24	for	for	IN
cord-341050-hnuogpqn	99	25	preventive	preventive	JJ
cord-341050-hnuogpqn	99	26	use	use	NN
cord-341050-hnuogpqn	99	27	against	against	IN
cord-341050-hnuogpqn	99	28	respiratory	respiratory	JJ
cord-341050-hnuogpqn	99	29	syncytial	syncytial	JJ
cord-341050-hnuogpqn	99	30	virus	virus	NN
cord-341050-hnuogpqn	99	31	(	(	-LRB-
cord-341050-hnuogpqn	99	32	WNV	WNV	NNP
cord-341050-hnuogpqn	99	33	infection	infection	NN
cord-341050-hnuogpqn	99	34	induces	induce	VBZ
cord-341050-hnuogpqn	99	35	a	a	DT
cord-341050-hnuogpqn	99	36	potent	potent	JJ
cord-341050-hnuogpqn	99	37	humoral	humoral	JJ
cord-341050-hnuogpqn	99	38	immune	immune	JJ
cord-341050-hnuogpqn	99	39	response	response	NN
cord-341050-hnuogpqn	99	40	,	,	,
cord-341050-hnuogpqn	99	41	which	which	WDT
cord-341050-hnuogpqn	99	42	is	be	VBZ
cord-341050-hnuogpqn	99	43	essential	essential	JJ
cord-341050-hnuogpqn	99	44	in	in	IN
cord-341050-hnuogpqn	99	45	controlling	control	VBG
cord-341050-hnuogpqn	99	46	viremia	viremia	NN
cord-341050-hnuogpqn	99	47	and	and	CC
cord-341050-hnuogpqn	99	48	limiting	limit	VBG
cord-341050-hnuogpqn	99	49	WNV	WNV	NNP
cord-341050-hnuogpqn	99	50	dissemination	dissemination	NN
cord-341050-hnuogpqn	99	51	to	to	IN
cord-341050-hnuogpqn	99	52	the	the	DT
cord-341050-hnuogpqn	99	53	CNS	CNS	NNP
cord-341050-hnuogpqn	99	54	[	[	-LRB-
cord-341050-hnuogpqn	99	55	72	72	CD
cord-341050-hnuogpqn	99	56	,	,	,
cord-341050-hnuogpqn	99	57	73	73	CD
cord-341050-hnuogpqn	99	58	]	]	-RRB-
cord-341050-hnuogpqn	99	59	.	.	.
cord-341050-hnuogpqn	100	1	Hyperimmune	Hyperimmune	NNP
cord-341050-hnuogpqn	100	2	sera	sera	NNP
cord-341050-hnuogpqn	100	3	,	,	,
cord-341050-hnuogpqn	100	4	γ	γ	NNP
cord-341050-hnuogpqn	100	5	-globulin	-globulin	NN
cord-341050-hnuogpqn	100	6	,	,	,
cord-341050-hnuogpqn	100	7	or	or	CC
cord-341050-hnuogpqn	100	8	affi	affi	NNP
cord-341050-hnuogpqn	100	9	nity	nity	NNP
cord-341050-hnuogpqn	100	10	-	-	HYPH
cord-341050-hnuogpqn	100	11	purifi	purifi	NNP
cord-341050-hnuogpqn	100	12	ed	ed	NN
cord-341050-hnuogpqn	100	13	antibodies	antibody	NNS
cord-341050-hnuogpqn	100	14	harvested	harvest	VBN
cord-341050-hnuogpqn	100	15	from	from	IN
cord-341050-hnuogpqn	100	16	WNV	WNV	NNP
cord-341050-hnuogpqn	100	17	-	-	HYPH
cord-341050-hnuogpqn	100	18	infected	infect	VBN
cord-341050-hnuogpqn	100	19	humans	human	NNS
cord-341050-hnuogpqn	100	20	and	and	CC
cord-341050-hnuogpqn	100	21	animals	animal	NNS
cord-341050-hnuogpqn	100	22	protect	protect	VBP
cord-341050-hnuogpqn	100	23	both	both	DT
cord-341050-hnuogpqn	100	24	wild	wild	JJ
cord-341050-hnuogpqn	100	25	-	-	HYPH
cord-341050-hnuogpqn	100	26	type	type	NN
cord-341050-hnuogpqn	100	27	and	and	CC
cord-341050-hnuogpqn	100	28	immunocompromised	immunocompromised	JJ
cord-341050-hnuogpqn	100	29	mice	mouse	NNS
cord-341050-hnuogpqn	100	30	from	from	IN
cord-341050-hnuogpqn	100	31	WNV	WNV	NNP
cord-341050-hnuogpqn	100	32	challenge	challenge	NN
cord-341050-hnuogpqn	100	33	in	in	IN
cord-341050-hnuogpqn	100	34	laboratory	laboratory	NN
cord-341050-hnuogpqn	100	35	conditions	condition	NNS
cord-341050-hnuogpqn	100	36	[	[	-LRB-
cord-341050-hnuogpqn	100	37	164	164	CD
cord-341050-hnuogpqn	100	38	-166	-166	NN
cord-341050-hnuogpqn	100	39	]	]	-RRB-
cord-341050-hnuogpqn	100	40	.	.	.
cord-341050-hnuogpqn	101	1	In	in	IN
cord-341050-hnuogpqn	101	2	addition	addition	NN
cord-341050-hnuogpqn	101	3	,	,	,
cord-341050-hnuogpqn	101	4	WNV	WNV	NNP
cord-341050-hnuogpqn	101	5	patients	patient	NNS
cord-341050-hnuogpqn	101	6	who	who	WP
cord-341050-hnuogpqn	101	7	received	receive	VBD
cord-341050-hnuogpqn	101	8	antibodies	antibody	NNS
cord-341050-hnuogpqn	101	9	from	from	IN
cord-341050-hnuogpqn	101	10	the	the	DT
cord-341050-hnuogpqn	101	11	WNV	WNV	NNP
cord-341050-hnuogpqn	101	12	seropositive	seropositive	JJ
cord-341050-hnuogpqn	101	13	donors	donor	NNS
cord-341050-hnuogpqn	101	14	recovered	recover	VBD
cord-341050-hnuogpqn	101	15	from	from	IN
cord-341050-hnuogpqn	101	16	WNV	WNV	NNP
cord-341050-hnuogpqn	101	17	infection	infection	NN
cord-341050-hnuogpqn	101	18	[	[	-LRB-
cord-341050-hnuogpqn	101	19	167	167	CD
cord-341050-hnuogpqn	101	20	-171	-171	NN
cord-341050-hnuogpqn	101	21	]	]	-RRB-
cord-341050-hnuogpqn	101	22	.	.	.
cord-341050-hnuogpqn	102	1	These	these	DT
cord-341050-hnuogpqn	102	2	studies	study	NNS
cord-341050-hnuogpqn	102	3	not	not	RB
cord-341050-hnuogpqn	102	4	only	only	RB
cord-341050-hnuogpqn	102	5	encouraged	encourage	VBD
cord-341050-hnuogpqn	102	6	the	the	DT
cord-341050-hnuogpqn	102	7	efforts	effort	NNS
cord-341050-hnuogpqn	102	8	toward	toward	IN
cord-341050-hnuogpqn	102	9	the	the	DT
cord-341050-hnuogpqn	102	10	development	development	NN
cord-341050-hnuogpqn	102	11	of	of	IN
cord-341050-hnuogpqn	102	12	human	human	JJ
cord-341050-hnuogpqn	102	13	or	or	CC
cord-341050-hnuogpqn	102	14	humanized	humanize	VBN
cord-341050-hnuogpqn	102	15	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	102	16	antibodies	antibody	NNS
cord-341050-hnuogpqn	102	17	against	against	IN
cord-341050-hnuogpqn	102	18	WNV	WNV	NNP
cord-341050-hnuogpqn	102	19	,	,	,
cord-341050-hnuogpqn	102	20	but	but	CC
cord-341050-hnuogpqn	102	21	also	also	RB
cord-341050-hnuogpqn	102	22	led	lead	VBD
cord-341050-hnuogpqn	102	23	to	to	IN
cord-341050-hnuogpqn	102	24	the	the	DT
cord-341050-hnuogpqn	102	25	discovery	discovery	NN
cord-341050-hnuogpqn	102	26	of	of	IN
cord-341050-hnuogpqn	102	27	several	several	JJ
cord-341050-hnuogpqn	102	28	potent	potent	JJ
cord-341050-hnuogpqn	102	29	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	102	30	antibodies	antibody	NNS
cord-341050-hnuogpqn	102	31	that	that	WDT
cord-341050-hnuogpqn	102	32	showed	show	VBD
cord-341050-hnuogpqn	102	33	effi	effi	NNP
cord-341050-hnuogpqn	102	34	cient	cient	NNP
cord-341050-hnuogpqn	102	35	protection	protection	NN
cord-341050-hnuogpqn	102	36	of	of	IN
cord-341050-hnuogpqn	102	37	mice	mouse	NNS
cord-341050-hnuogpqn	102	38	and	and	CC
cord-341050-hnuogpqn	102	39	hamsters	hamster	NNS
cord-341050-hnuogpqn	102	40	from	from	IN
cord-341050-hnuogpqn	102	41	WNV	WNV	NNP
cord-341050-hnuogpqn	102	42	infection	infection	NN
cord-341050-hnuogpqn	102	43	[	[	-LRB-
cord-341050-hnuogpqn	102	44	172	172	CD
cord-341050-hnuogpqn	102	45	-175	-175	NN
cord-341050-hnuogpqn	102	46	]	]	-RRB-
cord-341050-hnuogpqn	102	47	.	.	.
cord-341050-hnuogpqn	103	1	Among	among	IN
cord-341050-hnuogpqn	103	2	these	these	DT
cord-341050-hnuogpqn	103	3	,	,	,
cord-341050-hnuogpqn	103	4	a	a	DT
cord-341050-hnuogpqn	103	5	humanized	humanize	VBN
cord-341050-hnuogpqn	103	6	anti	anti	JJ
cord-341050-hnuogpqn	103	7	-	-	JJ
cord-341050-hnuogpqn	103	8	WNV	wnv	JJ
cord-341050-hnuogpqn	103	9	mAb	mAb	NNS
cord-341050-hnuogpqn	103	10	(	(	-LRB-
cord-341050-hnuogpqn	103	11	Hu	Hu	NNP
cord-341050-hnuogpqn	103	12	-	-	HYPH
cord-341050-hnuogpqn	103	13	E16	E16	NNP
cord-341050-hnuogpqn	103	14	)	)	-RRB-
cord-341050-hnuogpqn	103	15	that	that	WDT
cord-341050-hnuogpqn	103	16	binds	bind	VBZ
cord-341050-hnuogpqn	103	17	to	to	IN
cord-341050-hnuogpqn	103	18	a	a	DT
cord-341050-hnuogpqn	103	19	highly	highly	RB
cord-341050-hnuogpqn	103	20	conserved	conserve	VBN
cord-341050-hnuogpqn	103	21	epitope	epitope	NN
cord-341050-hnuogpqn	103	22	in	in	IN
cord-341050-hnuogpqn	103	23	WNV	WNV	NNP
cord-341050-hnuogpqn	103	24	E	E	NNP
cord-341050-hnuogpqn	103	25	protein	protein	NN
cord-341050-hnuogpqn	103	26	blocks	block	VBZ
cord-341050-hnuogpqn	103	27	viral	viral	JJ
cord-341050-hnuogpqn	103	28	fusion	fusion	NN
cord-341050-hnuogpqn	103	29	and	and	CC
cord-341050-hnuogpqn	103	30	provide	provide	VB
cord-341050-hnuogpqn	103	31	post	post	JJ
cord-341050-hnuogpqn	103	32	-	-	JJ
cord-341050-hnuogpqn	103	33	exposure	exposure	JJ
cord-341050-hnuogpqn	103	34	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	103	35	potential	potential	NN
cord-341050-hnuogpqn	103	36	[	[	-LRB-
cord-341050-hnuogpqn	103	37	172	172	CD
cord-341050-hnuogpqn	103	38	]	]	-RRB-
cord-341050-hnuogpqn	103	39	.	.	.
cord-341050-hnuogpqn	104	1	This	this	DT
cord-341050-hnuogpqn	104	2	antibody	antibody	NN
cord-341050-hnuogpqn	104	3	is	be	VBZ
cord-341050-hnuogpqn	104	4	currently	currently	RB
cord-341050-hnuogpqn	104	5	being	be	VBG
cord-341050-hnuogpqn	104	6	assessed	assess	VBN
cord-341050-hnuogpqn	104	7	for	for	IN
cord-341050-hnuogpqn	104	8	its	-PRON-	PRP$
cord-341050-hnuogpqn	104	9	potential	potential	JJ
cord-341050-hnuogpqn	104	10	use	use	NN
cord-341050-hnuogpqn	104	11	as	as	IN
cord-341050-hnuogpqn	104	12	a	a	DT
cord-341050-hnuogpqn	104	13	WNV	WNV	NNP
cord-341050-hnuogpqn	104	14	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	104	15	antibody	antibody	NN
cord-341050-hnuogpqn	104	16	[	[	-LRB-
cord-341050-hnuogpqn	104	17	176	176	CD
cord-341050-hnuogpqn	104	18	]	]	-RRB-
cord-341050-hnuogpqn	104	19	.	.	.
cord-341050-hnuogpqn	105	1	The	the	DT
cord-341050-hnuogpqn	105	2	phase	phase	NN
cord-341050-hnuogpqn	105	3	I	-PRON-	PRP
cord-341050-hnuogpqn	105	4	clinical	clinical	JJ
cord-341050-hnuogpqn	105	5	trial	trial	NN
cord-341050-hnuogpqn	105	6	showed	show	VBD
cord-341050-hnuogpqn	105	7	that	that	IN
cord-341050-hnuogpqn	105	8	another	another	DT
cord-341050-hnuogpqn	105	9	humanized	humanize	VBN
cord-341050-hnuogpqn	105	10	recombinant	recombinant	JJ
cord-341050-hnuogpqn	105	11	antibody	antibody	NN
cord-341050-hnuogpqn	105	12	targeting	target	VBG
cord-341050-hnuogpqn	105	13	E	e	NN
cord-341050-hnuogpqn	105	14	protein	protein	NN
cord-341050-hnuogpqn	105	15	of	of	IN
cord-341050-hnuogpqn	105	16	WNV	WNV	NNP
cord-341050-hnuogpqn	105	17	(	(	-LRB-
cord-341050-hnuogpqn	105	18	known	know	VBN
cord-341050-hnuogpqn	105	19	as	as	IN
cord-341050-hnuogpqn	105	20	MGAWN1	mgawn1	NN
cord-341050-hnuogpqn	105	21	)	)	-RRB-
cord-341050-hnuogpqn	105	22	has	have	VBZ
cord-341050-hnuogpqn	105	23	a	a	DT
cord-341050-hnuogpqn	105	24	good	good	JJ
cord-341050-hnuogpqn	105	25	safety	safety	NN
cord-341050-hnuogpqn	105	26	and	and	CC
cord-341050-hnuogpqn	105	27	tolerance	tolerance	NN
cord-341050-hnuogpqn	105	28	profi	profi	NNP
cord-341050-hnuogpqn	105	29	le	le	NNP
cord-341050-hnuogpqn	105	30	in	in	IN
cord-341050-hnuogpqn	105	31	healthy	healthy	JJ
cord-341050-hnuogpqn	105	32	humans	human	NNS
cord-341050-hnuogpqn	105	33	[	[	-LRB-
cord-341050-hnuogpqn	105	34	177	177	CD
cord-341050-hnuogpqn	105	35	]	]	-RRB-
cord-341050-hnuogpqn	105	36	,	,	,
cord-341050-hnuogpqn	105	37	however	however	RB
cord-341050-hnuogpqn	105	38	,	,	,
cord-341050-hnuogpqn	105	39	the	the	DT
cord-341050-hnuogpqn	105	40	phase	phase	NN
cord-341050-hnuogpqn	105	41	II	ii	CD
cord-341050-hnuogpqn	105	42	trial	trial	NN
cord-341050-hnuogpqn	105	43	to	to	TO
cord-341050-hnuogpqn	105	44	assess	assess	VB
cord-341050-hnuogpqn	105	45	its	-PRON-	PRP$
cord-341050-hnuogpqn	105	46	effi	effi	NNP
cord-341050-hnuogpqn	105	47	cacy	cacy	NN
cord-341050-hnuogpqn	105	48	in	in	IN
cord-341050-hnuogpqn	105	49	WNV	WNV	NNP
cord-341050-hnuogpqn	105	50	infection	infection	NN
cord-341050-hnuogpqn	105	51	failed	fail	VBD
cord-341050-hnuogpqn	105	52	due	due	IN
cord-341050-hnuogpqn	105	53	to	to	IN
cord-341050-hnuogpqn	105	54	poor	poor	JJ
cord-341050-hnuogpqn	105	55	enrollment	enrollment	NN
cord-341050-hnuogpqn	105	56	of	of	IN
cord-341050-hnuogpqn	105	57	participants	participant	NNS
cord-341050-hnuogpqn	105	58	.	.	.
cord-341050-hnuogpqn	106	1	Besides	besides	IN
cord-341050-hnuogpqn	106	2	the	the	DT
cord-341050-hnuogpqn	106	3	development	development	NN
cord-341050-hnuogpqn	106	4	of	of	IN
cord-341050-hnuogpqn	106	5	whole	whole	JJ
cord-341050-hnuogpqn	106	6	antibody	antibody	NN
cord-341050-hnuogpqn	106	7	,	,	,
cord-341050-hnuogpqn	106	8	recombinant	recombinant	JJ
cord-341050-hnuogpqn	106	9	fusion	fusion	NN
cord-341050-hnuogpqn	106	10	proteins	protein	NNS
cord-341050-hnuogpqn	106	11	are	be	VBP
cord-341050-hnuogpqn	106	12	also	also	RB
cord-341050-hnuogpqn	106	13	generated	generate	VBN
cord-341050-hnuogpqn	106	14	from	from	IN
cord-341050-hnuogpqn	106	15	single	single	JJ
cord-341050-hnuogpqn	106	16	-	-	HYPH
cord-341050-hnuogpqn	106	17	chain	chain	NN
cord-341050-hnuogpqn	106	18	antibody	antibody	NN
cord-341050-hnuogpqn	106	19	fragment	fragment	NN
cord-341050-hnuogpqn	106	20	of	of	IN
cord-341050-hnuogpqn	106	21	the	the	DT
cord-341050-hnuogpqn	106	22	variable	variable	JJ
cord-341050-hnuogpqn	106	23	region	region	NN
cord-341050-hnuogpqn	106	24	.	.	.
cord-341050-hnuogpqn	107	1	Such	such	JJ
cord-341050-hnuogpqn	107	2	antibody	antibody	NN
cord-341050-hnuogpqn	107	3	fragments	fragment	NNS
cord-341050-hnuogpqn	107	4	that	that	WDT
cord-341050-hnuogpqn	107	5	target	target	VBP
cord-341050-hnuogpqn	107	6	E	e	NN
cord-341050-hnuogpqn	107	7	protein	protein	NN
cord-341050-hnuogpqn	107	8	may	may	MD
cord-341050-hnuogpqn	107	9	be	be	VB
cord-341050-hnuogpqn	107	10	potential	potential	JJ
cord-341050-hnuogpqn	107	11	candidates	candidate	NNS
cord-341050-hnuogpqn	107	12	for	for	IN
cord-341050-hnuogpqn	107	13	immunoprophylaxis	immunoprophylaxis	NNP
cord-341050-hnuogpqn	107	14	and	and	CC
cord-341050-hnuogpqn	107	15	therapy	therapy	NN
cord-341050-hnuogpqn	107	16	of	of	IN
cord-341050-hnuogpqn	107	17	WNV	WNV	NNP
cord-341050-hnuogpqn	107	18	infections	infection	NNS
cord-341050-hnuogpqn	107	19	.	.	.
cord-341050-hnuogpqn	108	1	A	a	DT
cord-341050-hnuogpqn	108	2	recombinant	recombinant	JJ
cord-341050-hnuogpqn	108	3	human	human	JJ
cord-341050-hnuogpqn	108	4	single	single	JJ
cord-341050-hnuogpqn	108	5	-	-	HYPH
cord-341050-hnuogpqn	108	6	chain	chain	NN
cord-341050-hnuogpqn	108	7	variable	variable	JJ
cord-341050-hnuogpqn	108	8	region	region	NN
cord-341050-hnuogpqn	108	9	antibody	antibody	NN
cord-341050-hnuogpqn	108	10	fragments	fragment	NNS
cord-341050-hnuogpqn	108	11	(	(	-LRB-
cord-341050-hnuogpqn	109	1	Fv	Fv	NNP
cord-341050-hnuogpqn	109	2	-	-	HYPH
cord-341050-hnuogpqn	109	3	Fc	Fc	NNP
cord-341050-hnuogpqn	109	4	)	)	-RRB-
cord-341050-hnuogpqn	109	5	fusion	fusion	NN
cord-341050-hnuogpqn	109	6	protein	protein	NN
cord-341050-hnuogpqn	109	7	has	have	VBZ
cord-341050-hnuogpqn	109	8	a	a	DT
cord-341050-hnuogpqn	109	9	protective	protective	JJ
cord-341050-hnuogpqn	109	10	role	role	NN
cord-341050-hnuogpqn	109	11	against	against	IN
cord-341050-hnuogpqn	109	12	WNV	WNV	NNP
cord-341050-hnuogpqn	109	13	infection	infection	NN
cord-341050-hnuogpqn	109	14	in	in	IN
cord-341050-hnuogpqn	109	15	mice	mouse	NNS
cord-341050-hnuogpqn	109	16	[	[	-LRB-
cord-341050-hnuogpqn	109	17	178	178	CD
cord-341050-hnuogpqn	109	18	]	]	-RRB-
cord-341050-hnuogpqn	109	19	.	.	.
cord-341050-hnuogpqn	110	1	One	one	CD
cord-341050-hnuogpqn	110	2	of	of	IN
cord-341050-hnuogpqn	110	3	the	the	DT
cord-341050-hnuogpqn	110	4	potential	potential	JJ
cord-341050-hnuogpqn	110	5	limitations	limitation	NNS
cord-341050-hnuogpqn	110	6	of	of	IN
cord-341050-hnuogpqn	110	7	this	this	DT
cord-341050-hnuogpqn	110	8	approach	approach	NN
cord-341050-hnuogpqn	110	9	is	be	VBZ
cord-341050-hnuogpqn	110	10	antibodydependent	antibodydependent	NN
cord-341050-hnuogpqn	110	11	enhancement	enhancement	NN
cord-341050-hnuogpqn	110	12	(	(	-LRB-
cord-341050-hnuogpqn	110	13	ADE	ADE	NNP
cord-341050-hnuogpqn	110	14	)	)	-RRB-
cord-341050-hnuogpqn	110	15	,	,	,
cord-341050-hnuogpqn	110	16	a	a	DT
cord-341050-hnuogpqn	110	17	phenomenon	phenomenon	NN
cord-341050-hnuogpqn	110	18	by	by	IN
cord-341050-hnuogpqn	110	19	which	which	WDT
cord-341050-hnuogpqn	110	20	infection	infection	NN
cord-341050-hnuogpqn	110	21	of	of	IN
cord-341050-hnuogpqn	110	22	some	some	DT
cord-341050-hnuogpqn	110	23	viruses	virus	NNS
cord-341050-hnuogpqn	110	24	is	be	VBZ
cord-341050-hnuogpqn	110	25	enhanced	enhance	VBN
cord-341050-hnuogpqn	110	26	by	by	IN
cord-341050-hnuogpqn	110	27	virus	virus	NN
cord-341050-hnuogpqn	110	28	-	-	HYPH
cord-341050-hnuogpqn	110	29	reactive	reactive	JJ
cord-341050-hnuogpqn	110	30	antibodies	antibody	NNS
cord-341050-hnuogpqn	110	31	resulting	result	VBG
cord-341050-hnuogpqn	110	32	in	in	IN
cord-341050-hnuogpqn	110	33	more	more	JJR
cord-341050-hnuogpqn	110	34	effi	effi	NNP
cord-341050-hnuogpqn	110	35	cient	cient	NNP
cord-341050-hnuogpqn	110	36	virus	virus	NN
cord-341050-hnuogpqn	110	37	entry	entry	NN
cord-341050-hnuogpqn	110	38	through	through	IN
cord-341050-hnuogpqn	110	39	Fc	Fc	NNP
cord-341050-hnuogpqn	110	40	receptor	receptor	NN
cord-341050-hnuogpqn	110	41	-	-	HYPH
cord-341050-hnuogpqn	110	42	mediated	mediate	VBN
cord-341050-hnuogpqn	110	43	pathways	pathway	NNS
cord-341050-hnuogpqn	110	44	.	.	.
cord-341050-hnuogpqn	111	1	This	this	DT
cord-341050-hnuogpqn	111	2	phenomenon	phenomenon	NN
cord-341050-hnuogpqn	111	3	plays	play	VBZ
cord-341050-hnuogpqn	111	4	a	a	DT
cord-341050-hnuogpqn	111	5	role	role	NN
cord-341050-hnuogpqn	111	6	in	in	IN
cord-341050-hnuogpqn	111	7	the	the	DT
cord-341050-hnuogpqn	111	8	pathology	pathology	NN
cord-341050-hnuogpqn	111	9	of	of	IN
cord-341050-hnuogpqn	111	10	severe	severe	JJ
cord-341050-hnuogpqn	111	11	dengue	dengue	NN
cord-341050-hnuogpqn	111	12	infection	infection	NN
cord-341050-hnuogpqn	111	13	and	and	CC
cord-341050-hnuogpqn	111	14	has	have	VBZ
cord-341050-hnuogpqn	111	15	also	also	RB
cord-341050-hnuogpqn	111	16	been	be	VBN
cord-341050-hnuogpqn	111	17	observed	observe	VBN
cord-341050-hnuogpqn	111	18	in	in	IN
cord-341050-hnuogpqn	111	19	WNV	WNV	NNP
cord-341050-hnuogpqn	111	20	in	in	IN
cord-341050-hnuogpqn	111	21	vitro	vitro	FW
cord-341050-hnuogpqn	111	22	[	[	-LRB-
cord-341050-hnuogpqn	111	23	179	179	CD
cord-341050-hnuogpqn	111	24	]	]	-RRB-
cord-341050-hnuogpqn	111	25	.	.	.
cord-341050-hnuogpqn	112	1	Although	although	IN
cord-341050-hnuogpqn	112	2	the	the	DT
cord-341050-hnuogpqn	112	3	role	role	NN
cord-341050-hnuogpqn	112	4	of	of	IN
cord-341050-hnuogpqn	112	5	ADE	ADE	NNP
cord-341050-hnuogpqn	112	6	in	in	IN
cord-341050-hnuogpqn	112	7	WNV	WNV	NNP
cord-341050-hnuogpqn	112	8	disease	disease	NN
cord-341050-hnuogpqn	112	9	in	in	IN
cord-341050-hnuogpqn	112	10	unclear	unclear	JJ
cord-341050-hnuogpqn	112	11	,	,	,
cord-341050-hnuogpqn	112	12	the	the	DT
cord-341050-hnuogpqn	112	13	development	development	NN
cord-341050-hnuogpqn	112	14	of	of	IN
cord-341050-hnuogpqn	112	15	a	a	DT
cord-341050-hnuogpqn	112	16	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	112	17	antibody	antibody	NN
cord-341050-hnuogpqn	112	18	against	against	IN
cord-341050-hnuogpqn	112	19	WNV	WNV	NNP
cord-341050-hnuogpqn	112	20	should	should	MD
cord-341050-hnuogpqn	112	21	address	address	VB
cord-341050-hnuogpqn	112	22	this	this	DT
cord-341050-hnuogpqn	112	23	potential	potential	JJ
cord-341050-hnuogpqn	112	24	issue	issue	NN
cord-341050-hnuogpqn	112	25	.	.	.
cord-341050-hnuogpqn	113	1	Another	another	DT
cord-341050-hnuogpqn	113	2	limitation	limitation	NN
cord-341050-hnuogpqn	113	3	of	of	IN
cord-341050-hnuogpqn	113	4	antibody	antibody	NN
cord-341050-hnuogpqn	113	5	-	-	HYPH
cord-341050-hnuogpqn	113	6	based	base	VBN
cord-341050-hnuogpqn	113	7	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	113	8	is	be	VBZ
cord-341050-hnuogpqn	113	9	high	high	JJ
cord-341050-hnuogpqn	113	10	production	production	NN
cord-341050-hnuogpqn	113	11	cost	cost	NN
cord-341050-hnuogpqn	113	12	,	,	,
cord-341050-hnuogpqn	113	13	which	which	WDT
cord-341050-hnuogpqn	113	14	limits	limit	VBZ
cord-341050-hnuogpqn	113	15	mAb	mab	NN
cord-341050-hnuogpqn	113	16	scalability	scalability	NN
cord-341050-hnuogpqn	113	17	.	.	.
cord-341050-hnuogpqn	114	1	Producing	produce	VBG
cord-341050-hnuogpqn	114	2	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	114	3	proteins	protein	NNS
cord-341050-hnuogpqn	114	4	,	,	,
cord-341050-hnuogpqn	114	5	including	include	VBG
cord-341050-hnuogpqn	114	6	antibodies	antibody	NNS
cord-341050-hnuogpqn	114	7	in	in	IN
cord-341050-hnuogpqn	114	8	plants	plant	NNS
cord-341050-hnuogpqn	114	9	,	,	,
cord-341050-hnuogpqn	114	10	may	may	MD
cord-341050-hnuogpqn	114	11	be	be	VB
cord-341050-hnuogpqn	114	12	a	a	DT
cord-341050-hnuogpqn	114	13	promising	promising	JJ
cord-341050-hnuogpqn	114	14	solution	solution	NN
cord-341050-hnuogpqn	114	15	.	.	.
cord-341050-hnuogpqn	115	1	Feasibility	feasibility	NN
cord-341050-hnuogpqn	115	2	of	of	IN
cord-341050-hnuogpqn	115	3	this	this	DT
cord-341050-hnuogpqn	115	4	approach	approach	NN
cord-341050-hnuogpqn	115	5	has	have	VBZ
cord-341050-hnuogpqn	115	6	been	be	VBN
cord-341050-hnuogpqn	115	7	affi	affi	VBN
cord-341050-hnuogpqn	115	8	rmed	rme	VBN
cord-341050-hnuogpqn	115	9	by	by	IN
cord-341050-hnuogpqn	115	10	the	the	DT
cord-341050-hnuogpqn	115	11	successful	successful	JJ
cord-341050-hnuogpqn	115	12	production	production	NN
cord-341050-hnuogpqn	115	13	of	of	IN
cord-341050-hnuogpqn	115	14	anti	anti	JJ
cord-341050-hnuogpqn	115	15	-	-	JJ
cord-341050-hnuogpqn	115	16	WNV	wnv	JJ
cord-341050-hnuogpqn	115	17	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	115	18	antibody	antibody	NN
cord-341050-hnuogpqn	115	19	Hu	Hu	NNP
cord-341050-hnuogpqn	115	20	-	-	HYPH
cord-341050-hnuogpqn	115	21	E16	E16	NNP
cord-341050-hnuogpqn	115	22	in	in	IN
cord-341050-hnuogpqn	115	23	plants	plant	NNS
cord-341050-hnuogpqn	115	24	(	(	-LRB-
cord-341050-hnuogpqn	115	25	Nicotiana	Nicotiana	NNP
cord-341050-hnuogpqn	115	26	benthamiana	benthamiana	NNP
cord-341050-hnuogpqn	115	27	)	)	-RRB-
cord-341050-hnuogpqn	116	1	(	(	-LRB-
cord-341050-hnuogpqn	116	2	MAb	MAb	NNS
cord-341050-hnuogpqn	116	3	-	-	,
cord-341050-hnuogpqn	116	4	pE16	pE16	NNP
cord-341050-hnuogpqn	116	5	)	)	-RRB-
cord-341050-hnuogpqn	117	1	[	[	-LRB-
cord-341050-hnuogpqn	117	2	180	180	CD
cord-341050-hnuogpqn	117	3	,	,	,
cord-341050-hnuogpqn	117	4	181	181	CD
cord-341050-hnuogpqn	117	5	]	]	-RRB-
cord-341050-hnuogpqn	117	6	.	.	.
cord-341050-hnuogpqn	118	1	The	the	DT
cord-341050-hnuogpqn	118	2	plant	plant	NN
cord-341050-hnuogpqn	118	3	-	-	HYPH
cord-341050-hnuogpqn	118	4	derived	derive	VBN
cord-341050-hnuogpqn	118	5	MAb	MAb	NNS
cord-341050-hnuogpqn	118	6	-	-	:
cord-341050-hnuogpqn	118	7	pE16	pE16	NNP
cord-341050-hnuogpqn	118	8	confers	confer	VBZ
cord-341050-hnuogpqn	118	9	a	a	DT
cord-341050-hnuogpqn	118	10	potent	potent	JJ
cord-341050-hnuogpqn	118	11	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	118	12	activity	activity	NN
cord-341050-hnuogpqn	118	13	in	in	IN
cord-341050-hnuogpqn	118	14	vitro	vitro	FW
cord-341050-hnuogpqn	118	15	without	without	IN
cord-341050-hnuogpqn	118	16	ADE	ADE	NNP
cord-341050-hnuogpqn	118	17	,	,	,
cord-341050-hnuogpqn	118	18	effi	effi	NNP
cord-341050-hnuogpqn	118	19	ciently	ciently	NNP
cord-341050-hnuogpqn	118	20	binds	bind	VBZ
cord-341050-hnuogpqn	118	21	to	to	TO
cord-341050-hnuogpqn	118	22	complement	complement	VB
cord-341050-hnuogpqn	118	23	and	and	CC
cord-341050-hnuogpqn	118	24	Fc	Fc	NNP
cord-341050-hnuogpqn	118	25	receptors	receptor	NNS
cord-341050-hnuogpqn	118	26	,	,	,
cord-341050-hnuogpqn	118	27	and	and	CC
cord-341050-hnuogpqn	118	28	protects	protect	VBZ
cord-341050-hnuogpqn	118	29	mice	mouse	NNS
cord-341050-hnuogpqn	118	30	against	against	IN
cord-341050-hnuogpqn	118	31	lethal	lethal	JJ
cord-341050-hnuogpqn	118	32	WNV	WNV	NNP
cord-341050-hnuogpqn	118	33	-	-	HYPH
cord-341050-hnuogpqn	118	34	challenge	challenge	NN
cord-341050-hnuogpqn	118	35	with	with	IN
cord-341050-hnuogpqn	118	36	similar	similar	JJ
cord-341050-hnuogpqn	118	37	potency	potency	NN
cord-341050-hnuogpqn	118	38	as	as	IN
cord-341050-hnuogpqn	118	39	their	-PRON-	PRP$
cord-341050-hnuogpqn	118	40	mammalian	mammalian	JJ
cord-341050-hnuogpqn	118	41	-	-	HYPH
cord-341050-hnuogpqn	118	42	cell	cell	NN
cord-341050-hnuogpqn	118	43	counterparts	counterpart	NNS
cord-341050-hnuogpqn	118	44	[	[	-LRB-
cord-341050-hnuogpqn	118	45	180	180	CD
cord-341050-hnuogpqn	118	46	,	,	,
cord-341050-hnuogpqn	118	47	182	182	CD
cord-341050-hnuogpqn	118	48	,	,	,
cord-341050-hnuogpqn	118	49	183	183	CD
cord-341050-hnuogpqn	118	50	]	]	-RRB-
cord-341050-hnuogpqn	118	51	.	.	.
cord-341050-hnuogpqn	119	1	Antibodies	antibody	NNS
cord-341050-hnuogpqn	119	2	employ	employ	VBP
cord-341050-hnuogpqn	119	3	several	several	JJ
cord-341050-hnuogpqn	119	4	mechanisms	mechanism	NNS
cord-341050-hnuogpqn	119	5	to	to	TO
cord-341050-hnuogpqn	119	6	control	control	VB
cord-341050-hnuogpqn	119	7	WNV	WNV	NNP
cord-341050-hnuogpqn	119	8	and	and	CC
cord-341050-hnuogpqn	119	9	other	other	JJ
cord-341050-hnuogpqn	119	10	viral	viral	JJ
cord-341050-hnuogpqn	119	11	infections	infection	NNS
cord-341050-hnuogpqn	119	12	,	,	,
cord-341050-hnuogpqn	119	13	including	include	VBG
cord-341050-hnuogpqn	119	14	blockage	blockage	NN
cord-341050-hnuogpqn	119	15	of	of	IN
cord-341050-hnuogpqn	119	16	viral	viral	JJ
cord-341050-hnuogpqn	119	17	entry	entry	NN
cord-341050-hnuogpqn	119	18	,	,	,
cord-341050-hnuogpqn	119	19	Fc	Fc	NNP
cord-341050-hnuogpqn	119	20	-	-	HYPH
cord-341050-hnuogpqn	119	21	dependent	dependent	JJ
cord-341050-hnuogpqn	119	22	viral	viral	JJ
cord-341050-hnuogpqn	119	23	clearance	clearance	NN
cord-341050-hnuogpqn	119	24	,	,	,
cord-341050-hnuogpqn	119	25	complement	complement	NN
cord-341050-hnuogpqn	119	26	-	-	HYPH
cord-341050-hnuogpqn	119	27	mediated	mediate	VBN
cord-341050-hnuogpqn	119	28	viral	viral	JJ
cord-341050-hnuogpqn	119	29	lysis	lysis	NN
cord-341050-hnuogpqn	119	30	,	,	,
cord-341050-hnuogpqn	119	31	and	and	CC
cord-341050-hnuogpqn	119	32	antibodydependent	antibodydependent	NN
cord-341050-hnuogpqn	119	33	cytotoxicity	cytotoxicity	NN
cord-341050-hnuogpqn	119	34	of	of	IN
cord-341050-hnuogpqn	119	35	infected	infected	JJ
cord-341050-hnuogpqn	119	36	cells	cell	NNS
cord-341050-hnuogpqn	119	37	.	.	.
cord-341050-hnuogpqn	120	1	Most	Most	JJS
cord-341050-hnuogpqn	120	2	of	of	IN
cord-341050-hnuogpqn	120	3	the	the	DT
cord-341050-hnuogpqn	120	4	current	current	JJ
cord-341050-hnuogpqn	120	5	researches	research	NNS
cord-341050-hnuogpqn	120	6	in	in	IN
cord-341050-hnuogpqn	120	7	the	the	DT
cord-341050-hnuogpqn	120	8	development	development	NN
cord-341050-hnuogpqn	120	9	of	of	IN
cord-341050-hnuogpqn	120	10	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	120	11	antibodies	antibody	NNS
cord-341050-hnuogpqn	120	12	against	against	IN
cord-341050-hnuogpqn	120	13	WNV	WNV	NNP
cord-341050-hnuogpqn	120	14	are	be	VBP
cord-341050-hnuogpqn	120	15	designed	design	VBN
cord-341050-hnuogpqn	120	16	and	and	CC
cord-341050-hnuogpqn	120	17	tested	test	VBN
cord-341050-hnuogpqn	120	18	for	for	IN
cord-341050-hnuogpqn	120	19	effi	effi	NNP
cord-341050-hnuogpqn	120	20	cient	cient	NNP
cord-341050-hnuogpqn	120	21	neutralization	neutralization	NN
cord-341050-hnuogpqn	120	22	potential	potential	NN
cord-341050-hnuogpqn	120	23	[	[	-LRB-
cord-341050-hnuogpqn	120	24	184	184	CD
cord-341050-hnuogpqn	120	25	,	,	,
cord-341050-hnuogpqn	120	26	185	185	CD
cord-341050-hnuogpqn	120	27	]	]	-RRB-
cord-341050-hnuogpqn	120	28	.	.	.
cord-341050-hnuogpqn	121	1	Increased	increase	VBN
cord-341050-hnuogpqn	121	2	understandings	understanding	NNS
cord-341050-hnuogpqn	121	3	of	of	IN
cord-341050-hnuogpqn	121	4	the	the	DT
cord-341050-hnuogpqn	121	5	biology	biology	NN
cord-341050-hnuogpqn	121	6	of	of	IN
cord-341050-hnuogpqn	121	7	antibody	antibody	NN
cord-341050-hnuogpqn	121	8	Fc	Fc	NNP
cord-341050-hnuogpqn	121	9	regions	region	NNS
cord-341050-hnuogpqn	121	10	,	,	,
cord-341050-hnuogpqn	121	11	in	in	IN
cord-341050-hnuogpqn	121	12	particular	particular	JJ
cord-341050-hnuogpqn	121	13	,	,	,
cord-341050-hnuogpqn	121	14	the	the	DT
cord-341050-hnuogpqn	121	15	roles	role	NNS
cord-341050-hnuogpqn	121	16	of	of	IN
cord-341050-hnuogpqn	121	17	glycan	glycan	NN
cord-341050-hnuogpqn	121	18	in	in	IN
cord-341050-hnuogpqn	121	19	Fc	Fc	NNP
cord-341050-hnuogpqn	121	20	mediated	mediate	VBN
cord-341050-hnuogpqn	121	21	functions	function	NNS
cord-341050-hnuogpqn	121	22	may	may	MD
cord-341050-hnuogpqn	121	23	facilitate	facilitate	VB
cord-341050-hnuogpqn	121	24	the	the	DT
cord-341050-hnuogpqn	121	25	design	design	NN
cord-341050-hnuogpqn	121	26	and	and	CC
cord-341050-hnuogpqn	121	27	development	development	NN
cord-341050-hnuogpqn	121	28	of	of	IN
cord-341050-hnuogpqn	121	29	high	high	JJ
cord-341050-hnuogpqn	121	30	-	-	HYPH
cord-341050-hnuogpqn	121	31	quality	quality	NN
cord-341050-hnuogpqn	121	32	antibody	antibody	NN
cord-341050-hnuogpqn	121	33	through	through	IN
cord-341050-hnuogpqn	121	34	glycoengineering	glycoengineere	VBG
cord-341050-hnuogpqn	121	35	[	[	-LRB-
cord-341050-hnuogpqn	121	36	186	186	CD
cord-341050-hnuogpqn	121	37	,	,	,
cord-341050-hnuogpqn	121	38	187	187	CD
cord-341050-hnuogpqn	121	39	]	]	-RRB-
cord-341050-hnuogpqn	121	40	.	.	.
cord-341050-hnuogpqn	122	1	Such	such	JJ
cord-341050-hnuogpqn	122	2	engineering	engineering	NN
cord-341050-hnuogpqn	122	3	of	of	IN
cord-341050-hnuogpqn	122	4	antibody	antibody	NN
cord-341050-hnuogpqn	122	5	Fc	Fc	NNP
cord-341050-hnuogpqn	122	6	region	region	NN
cord-341050-hnuogpqn	122	7	may	may	MD
cord-341050-hnuogpqn	122	8	be	be	VB
cord-341050-hnuogpqn	122	9	used	use	VBN
cord-341050-hnuogpqn	122	10	to	to	TO
cord-341050-hnuogpqn	122	11	overcome	overcome	VB
cord-341050-hnuogpqn	122	12	ADE	ADE	NNP
cord-341050-hnuogpqn	122	13	,	,	,
cord-341050-hnuogpqn	122	14	modulate	modulate	VB
cord-341050-hnuogpqn	122	15	pharmacokinetics	pharmacokinetic	NNS
cord-341050-hnuogpqn	122	16	,	,	,
cord-341050-hnuogpqn	122	17	and	and	CC
cord-341050-hnuogpqn	122	18	enhance	enhance	VB
cord-341050-hnuogpqn	122	19	Fc	Fc	NNP
cord-341050-hnuogpqn	122	20	mediated	mediate	VBN
cord-341050-hnuogpqn	122	21	effector	effector	NN
cord-341050-hnuogpqn	122	22	functions	function	NNS
cord-341050-hnuogpqn	122	23	,	,	,
cord-341050-hnuogpqn	122	24	such	such	JJ
cord-341050-hnuogpqn	122	25	as	as	IN
cord-341050-hnuogpqn	122	26	enhancement	enhancement	NN
cord-341050-hnuogpqn	122	27	of	of	IN
cord-341050-hnuogpqn	122	28	antibody	antibody	NN
cord-341050-hnuogpqn	122	29	-	-	HYPH
cord-341050-hnuogpqn	122	30	dependent	dependent	JJ
cord-341050-hnuogpqn	122	31	cell	cell	NN
cord-341050-hnuogpqn	122	32	mediated	mediate	VBN
cord-341050-hnuogpqn	122	33	cytotoxicity	cytotoxicity	NN
cord-341050-hnuogpqn	122	34	(	(	-LRB-
cord-341050-hnuogpqn	122	35	ADCC	ADCC	NNP
cord-341050-hnuogpqn	122	36	)	)	-RRB-
cord-341050-hnuogpqn	122	37	,	,	,
cord-341050-hnuogpqn	122	38	complement	complement	VBP
cord-341050-hnuogpqn	122	39	binding	binding	NN
cord-341050-hnuogpqn	122	40	,	,	,
cord-341050-hnuogpqn	122	41	and	and	CC
cord-341050-hnuogpqn	122	42	phagocytosis	phagocytosis	NN
cord-341050-hnuogpqn	122	43	[	[	-LRB-
cord-341050-hnuogpqn	122	44	188	188	CD
cord-341050-hnuogpqn	122	45	]	]	-RRB-
cord-341050-hnuogpqn	122	46	.	.	.
cord-341050-hnuogpqn	123	1	Recent	recent	JJ
cord-341050-hnuogpqn	123	2	technological	technological	JJ
cord-341050-hnuogpqn	123	3	advancement	advancement	NN
cord-341050-hnuogpqn	123	4	not	not	RB
cord-341050-hnuogpqn	123	5	only	only	RB
cord-341050-hnuogpqn	123	6	in	in	IN
cord-341050-hnuogpqn	123	7	development	development	NN
cord-341050-hnuogpqn	123	8	,	,	,
cord-341050-hnuogpqn	123	9	production	production	NN
cord-341050-hnuogpqn	123	10	,	,	,
cord-341050-hnuogpqn	123	11	and	and	CC
cord-341050-hnuogpqn	123	12	purifi	purifi	NNP
cord-341050-hnuogpqn	123	13	cation	cation	NN
cord-341050-hnuogpqn	123	14	but	but	CC
cord-341050-hnuogpqn	123	15	also	also	RB
cord-341050-hnuogpqn	123	16	in	in	IN
cord-341050-hnuogpqn	123	17	ease	ease	NN
cord-341050-hnuogpqn	123	18	of	of	IN
cord-341050-hnuogpqn	123	19	achieving	achieve	VBG
cord-341050-hnuogpqn	123	20	desirable	desirable	JJ
cord-341050-hnuogpqn	123	21	quality	quality	NN
cord-341050-hnuogpqn	123	22	,	,	,
cord-341050-hnuogpqn	123	23	effi	effi	NNP
cord-341050-hnuogpqn	123	24	cacy	cacy	NNP
cord-341050-hnuogpqn	123	25	,	,	,
cord-341050-hnuogpqn	123	26	and	and	CC
cord-341050-hnuogpqn	123	27	safety	safety	NN
cord-341050-hnuogpqn	123	28	required	require	VBN
cord-341050-hnuogpqn	123	29	for	for	IN
cord-341050-hnuogpqn	123	30	the	the	DT
cord-341050-hnuogpqn	123	31	FDA	FDA	NNP
cord-341050-hnuogpqn	123	32	approval	approval	NN
cord-341050-hnuogpqn	124	1	makes	make	VBZ
cord-341050-hnuogpqn	124	2	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	124	3	antibodies	antibody	NNS
cord-341050-hnuogpqn	124	4	a	a	DT
cord-341050-hnuogpqn	124	5	promising	promising	JJ
cord-341050-hnuogpqn	124	6	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	124	7	option	option	NN
cord-341050-hnuogpqn	124	8	.	.	.
cord-341050-hnuogpqn	125	1	Thus	thus	RB
cord-341050-hnuogpqn	125	2	,	,	,
cord-341050-hnuogpqn	125	3	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	125	4	antibodies	antibody	NNS
cord-341050-hnuogpqn	125	5	may	may	MD
cord-341050-hnuogpqn	125	6	prove	prove	VB
cord-341050-hnuogpqn	125	7	useful	useful	JJ
cord-341050-hnuogpqn	125	8	for	for	IN
cord-341050-hnuogpqn	125	9	WNV	WNV	NNP
cord-341050-hnuogpqn	125	10	prophylaxis	prophylaxis	NN
cord-341050-hnuogpqn	125	11	and	and	CC
cord-341050-hnuogpqn	125	12	therapy	therapy	NN
cord-341050-hnuogpqn	125	13	particularly	particularly	RB
cord-341050-hnuogpqn	125	14	in	in	IN
cord-341050-hnuogpqn	125	15	the	the	DT
cord-341050-hnuogpqn	125	16	elderly	elderly	JJ
cord-341050-hnuogpqn	125	17	and	and	CC
cord-341050-hnuogpqn	125	18	immunocompromised	immunocompromised	JJ
cord-341050-hnuogpqn	125	19	individuals	individual	NNS
cord-341050-hnuogpqn	125	20	with	with	IN
cord-341050-hnuogpqn	125	21	limited	limited	JJ
cord-341050-hnuogpqn	125	22	ability	ability	NN
cord-341050-hnuogpqn	125	23	to	to	TO
cord-341050-hnuogpqn	125	24	respond	respond	VB
cord-341050-hnuogpqn	125	25	to	to	IN
cord-341050-hnuogpqn	125	26	a	a	DT
cord-341050-hnuogpqn	125	27	vaccine	vaccine	NN
cord-341050-hnuogpqn	125	28	.	.	.
cord-341050-hnuogpqn	126	1	To	to	TO
cord-341050-hnuogpqn	126	2	meet	meet	VB
cord-341050-hnuogpqn	126	3	its	-PRON-	PRP$
cord-341050-hnuogpqn	126	4	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	126	5	goal	goal	NN
cord-341050-hnuogpqn	126	6	,	,	,
cord-341050-hnuogpqn	126	7	a	a	DT
cord-341050-hnuogpqn	126	8	controlled	control	VBN
cord-341050-hnuogpqn	126	9	clinical	clinical	JJ
cord-341050-hnuogpqn	126	10	trial	trial	NN
cord-341050-hnuogpqn	126	11	of	of	IN
cord-341050-hnuogpqn	126	12	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	126	13	antibody	antibody	NN
cord-341050-hnuogpqn	126	14	should	should	MD
cord-341050-hnuogpqn	126	15	ensure	ensure	VB
cord-341050-hnuogpqn	126	16	its	-PRON-	PRP$
cord-341050-hnuogpqn	126	17	prophylactic	prophylactic	JJ
cord-341050-hnuogpqn	126	18	and	and	CC
cord-341050-hnuogpqn	126	19	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	126	20	effi	effi	NNP
cord-341050-hnuogpqn	126	21	cacy	cacy	NN
cord-341050-hnuogpqn	126	22	along	along	IN
cord-341050-hnuogpqn	126	23	with	with	IN
cord-341050-hnuogpqn	126	24	optimal	optimal	JJ
cord-341050-hnuogpqn	126	25	dose	dose	NN
cord-341050-hnuogpqn	126	26	and	and	CC
cord-341050-hnuogpqn	126	27	timing	timing	NN
cord-341050-hnuogpqn	126	28	of	of	IN
cord-341050-hnuogpqn	126	29	administration	administration	NN
cord-341050-hnuogpqn	126	30	across	across	IN
cord-341050-hnuogpqn	126	31	the	the	DT
cord-341050-hnuogpqn	126	32	range	range	NN
cord-341050-hnuogpqn	126	33	of	of	IN
cord-341050-hnuogpqn	126	34	patient	patient	JJ
cord-341050-hnuogpqn	126	35	groups	group	NNS
cord-341050-hnuogpqn	126	36	.	.	.
cord-341050-hnuogpqn	127	1	Development	development	NN
cord-341050-hnuogpqn	127	2	of	of	IN
cord-341050-hnuogpqn	127	3	effective	effective	JJ
cord-341050-hnuogpqn	127	4	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	127	5	have	have	VBP
cord-341050-hnuogpqn	127	6	been	be	VBN
cord-341050-hnuogpqn	127	7	successful	successful	JJ
cord-341050-hnuogpqn	127	8	in	in	IN
cord-341050-hnuogpqn	127	9	treating	treat	VBG
cord-341050-hnuogpqn	127	10	many	many	JJ
cord-341050-hnuogpqn	127	11	viral	viral	JJ
cord-341050-hnuogpqn	127	12	diseases	disease	NNS
cord-341050-hnuogpqn	127	13	including	include	VBG
cord-341050-hnuogpqn	127	14	infl	infl	XX
cord-341050-hnuogpqn	127	15	uenza	uenza	NNP
cord-341050-hnuogpqn	127	16	,	,	,
cord-341050-hnuogpqn	127	17	HIV-1	HIV-1	NNP
cord-341050-hnuogpqn	127	18	,	,	,
cord-341050-hnuogpqn	127	19	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	127	20	C	C	NNP
cord-341050-hnuogpqn	127	21	virus	virus	NN
cord-341050-hnuogpqn	127	22	(	(	-LRB-
cord-341050-hnuogpqn	127	23	HCV	HCV	NNP
cord-341050-hnuogpqn	127	24	)	)	-RRB-
cord-341050-hnuogpqn	127	25	,	,	,
cord-341050-hnuogpqn	127	26	and	and	CC
cord-341050-hnuogpqn	127	27	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	127	28	B	B	NNP
cord-341050-hnuogpqn	127	29	virus	virus	NN
cord-341050-hnuogpqn	127	30	(	(	-LRB-
cord-341050-hnuogpqn	127	31	HBV	HBV	NNP
cord-341050-hnuogpqn	127	32	)	)	-RRB-
cord-341050-hnuogpqn	127	33	.	.	.
cord-341050-hnuogpqn	128	1	WNV	WNV	NNP
cord-341050-hnuogpqn	128	2	causes	cause	VBZ
cord-341050-hnuogpqn	128	3	transient	transient	JJ
cord-341050-hnuogpqn	128	4	viremia	viremia	NN
cord-341050-hnuogpqn	128	5	in	in	IN
cord-341050-hnuogpqn	128	6	human	human	JJ
cord-341050-hnuogpqn	128	7	and	and	CC
cord-341050-hnuogpqn	128	8	animal	animal	NN
cord-341050-hnuogpqn	128	9	models	model	NNS
cord-341050-hnuogpqn	128	10	that	that	WDT
cord-341050-hnuogpqn	128	11	is	be	VBZ
cord-341050-hnuogpqn	128	12	associated	associate	VBN
cord-341050-hnuogpqn	128	13	with	with	IN
cord-341050-hnuogpqn	128	14	Treatment	Treatment	NNP
cord-341050-hnuogpqn	128	15	and	and	CC
cord-341050-hnuogpqn	128	16	Prevention	Prevention	NNP
cord-341050-hnuogpqn	128	17	Approaches	Approaches	NNPS
cord-341050-hnuogpqn	128	18	for	for	IN
cord-341050-hnuogpqn	128	19	WNV	WNV	NNP
cord-341050-hnuogpqn	129	1	its	-PRON-	PRP$
cord-341050-hnuogpqn	129	2	dissemination	dissemination	NN
cord-341050-hnuogpqn	129	3	to	to	IN
cord-341050-hnuogpqn	129	4	brain	brain	NN
cord-341050-hnuogpqn	129	5	and	and	CC
cord-341050-hnuogpqn	129	6	development	development	NN
cord-341050-hnuogpqn	129	7	of	of	IN
cord-341050-hnuogpqn	129	8	more	more	RBR
cord-341050-hnuogpqn	129	9	severe	severe	JJ
cord-341050-hnuogpqn	129	10	disease	disease	NN
cord-341050-hnuogpqn	129	11	[	[	-LRB-
cord-341050-hnuogpqn	129	12	73	73	CD
cord-341050-hnuogpqn	129	13	,	,	,
cord-341050-hnuogpqn	129	14	189	189	CD
cord-341050-hnuogpqn	129	15	-192	-192	RB
cord-341050-hnuogpqn	129	16	]	]	-RRB-
cord-341050-hnuogpqn	129	17	,	,	,
cord-341050-hnuogpqn	129	18	suggesting	suggest	VBG
cord-341050-hnuogpqn	129	19	that	that	IN
cord-341050-hnuogpqn	129	20	reducing	reduce	VBG
cord-341050-hnuogpqn	129	21	viral	viral	JJ
cord-341050-hnuogpqn	129	22	loads	load	NNS
cord-341050-hnuogpqn	129	23	by	by	IN
cord-341050-hnuogpqn	129	24	an	an	DT
cord-341050-hnuogpqn	129	25	antiviral	antiviral	JJ
cord-341050-hnuogpqn	129	26	drug	drug	NN
cord-341050-hnuogpqn	129	27	during	during	IN
cord-341050-hnuogpqn	129	28	the	the	DT
cord-341050-hnuogpqn	129	29	early	early	JJ
cord-341050-hnuogpqn	129	30	phase	phase	NN
cord-341050-hnuogpqn	129	31	of	of	IN
cord-341050-hnuogpqn	129	32	infection	infection	NN
cord-341050-hnuogpqn	129	33	may	may	MD
cord-341050-hnuogpqn	129	34	offer	offer	VB
cord-341050-hnuogpqn	129	35	effi	effi	NNP
cord-341050-hnuogpqn	129	36	cient	cient	NNP
cord-341050-hnuogpqn	129	37	control	control	NN
cord-341050-hnuogpqn	129	38	of	of	IN
cord-341050-hnuogpqn	129	39	WNV	WNV	NNP
cord-341050-hnuogpqn	129	40	or	or	CC
cord-341050-hnuogpqn	129	41	lessen	lessen	VB
cord-341050-hnuogpqn	129	42	the	the	DT
cord-341050-hnuogpqn	129	43	chances	chance	NNS
cord-341050-hnuogpqn	129	44	of	of	IN
cord-341050-hnuogpqn	129	45	progression	progression	NN
cord-341050-hnuogpqn	129	46	to	to	IN
cord-341050-hnuogpqn	129	47	neuroinvasive	neuroinvasive	JJ
cord-341050-hnuogpqn	129	48	diseases	disease	NNS
cord-341050-hnuogpqn	129	49	.	.	.
cord-341050-hnuogpqn	130	1	In	in	IN
cord-341050-hnuogpqn	130	2	addition	addition	NN
cord-341050-hnuogpqn	130	3	,	,	,
cord-341050-hnuogpqn	130	4	antiviral	antiviral	JJ
cord-341050-hnuogpqn	130	5	drugs	drug	NNS
cord-341050-hnuogpqn	130	6	are	be	VBP
cord-341050-hnuogpqn	130	7	particularly	particularly	RB
cord-341050-hnuogpqn	130	8	useful	useful	JJ
cord-341050-hnuogpqn	130	9	for	for	IN
cord-341050-hnuogpqn	130	10	the	the	DT
cord-341050-hnuogpqn	130	11	elderly	elderly	JJ
cord-341050-hnuogpqn	130	12	and	and	CC
cord-341050-hnuogpqn	130	13	the	the	DT
cord-341050-hnuogpqn	130	14	immunocompromised	immunocompromised	JJ
cord-341050-hnuogpqn	130	15	patients	patient	NNS
cord-341050-hnuogpqn	130	16	who	who	WP
cord-341050-hnuogpqn	130	17	may	may	MD
cord-341050-hnuogpqn	130	18	fail	fail	VB
cord-341050-hnuogpqn	130	19	to	to	TO
cord-341050-hnuogpqn	130	20	develop	develop	VB
cord-341050-hnuogpqn	130	21	effi	effi	NNP
cord-341050-hnuogpqn	130	22	cient	cient	NNP
cord-341050-hnuogpqn	130	23	vaccine	vaccine	NN
cord-341050-hnuogpqn	130	24	-induced	-induce	VBN
cord-341050-hnuogpqn	130	25	immunity	immunity	NN
cord-341050-hnuogpqn	130	26	.	.	.
cord-341050-hnuogpqn	131	1	Recent	recent	JJ
cord-341050-hnuogpqn	131	2	progress	progress	NN
cord-341050-hnuogpqn	131	3	in	in	IN
cord-341050-hnuogpqn	131	4	the	the	DT
cord-341050-hnuogpqn	131	5	structural	structural	JJ
cord-341050-hnuogpqn	131	6	characterization	characterization	NN
cord-341050-hnuogpqn	131	7	of	of	IN
cord-341050-hnuogpqn	131	8	WNV	WNV	NNP
cord-341050-hnuogpqn	131	9	and	and	CC
cord-341050-hnuogpqn	131	10	other	other	JJ
cord-341050-hnuogpqn	131	11	fl	fl	NNP
cord-341050-hnuogpqn	131	12	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	131	13	broadens	broaden	VBZ
cord-341050-hnuogpqn	131	14	the	the	DT
cord-341050-hnuogpqn	131	15	understanding	understanding	NN
cord-341050-hnuogpqn	131	16	of	of	IN
cord-341050-hnuogpqn	131	17	WNV	WNV	NNP
cord-341050-hnuogpqn	131	18	biology	biology	NN
cord-341050-hnuogpqn	131	19	and	and	CC
cord-341050-hnuogpqn	131	20	provides	provide	VBZ
cord-341050-hnuogpqn	131	21	a	a	DT
cord-341050-hnuogpqn	131	22	foundation	foundation	NN
cord-341050-hnuogpqn	131	23	for	for	IN
cord-341050-hnuogpqn	131	24	the	the	DT
cord-341050-hnuogpqn	131	25	development	development	NN
cord-341050-hnuogpqn	131	26	of	of	IN
cord-341050-hnuogpqn	131	27	small	small	JJ
cord-341050-hnuogpqn	131	28	molecule	molecule	NN
cord-341050-hnuogpqn	131	29	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	131	30	for	for	IN
cord-341050-hnuogpqn	131	31	WNV	WNV	NNP
cord-341050-hnuogpqn	131	32	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	131	33	[	[	-LRB-
cord-341050-hnuogpqn	131	34	34	34	CD
cord-341050-hnuogpqn	131	35	,	,	,
cord-341050-hnuogpqn	131	36	193	193	CD
cord-341050-hnuogpqn	131	37	]	]	-RRB-
cord-341050-hnuogpqn	131	38	.	.	.
cord-341050-hnuogpqn	132	1	In	in	IN
cord-341050-hnuogpqn	132	2	addition	addition	NN
cord-341050-hnuogpqn	132	3	,	,	,
cord-341050-hnuogpqn	132	4	better	well	JJR
cord-341050-hnuogpqn	132	5	understanding	understanding	NN
cord-341050-hnuogpqn	132	6	of	of	IN
cord-341050-hnuogpqn	132	7	the	the	DT
cord-341050-hnuogpqn	132	8	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	132	9	of	of	IN
cord-341050-hnuogpqn	132	10	WNV	WNV	NNP
cord-341050-hnuogpqn	132	11	and	and	CC
cord-341050-hnuogpqn	132	12	other	other	JJ
cord-341050-hnuogpqn	132	13	fl	fl	NNP
cord-341050-hnuogpqn	132	14	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	132	15	has	have	VBZ
cord-341050-hnuogpqn	132	16	offered	offer	VBN
cord-341050-hnuogpqn	132	17	new	new	JJ
cord-341050-hnuogpqn	132	18	opportunities	opportunity	NNS
cord-341050-hnuogpqn	132	19	for	for	IN
cord-341050-hnuogpqn	132	20	designing	design	VBG
cord-341050-hnuogpqn	132	21	many	many	JJ
cord-341050-hnuogpqn	132	22	different	different	JJ
cord-341050-hnuogpqn	132	23	classes	class	NNS
cord-341050-hnuogpqn	132	24	of	of	IN
cord-341050-hnuogpqn	132	25	promising	promising	JJ
cord-341050-hnuogpqn	132	26	antiviral	antiviral	JJ
cord-341050-hnuogpqn	132	27	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	132	28	by	by	IN
cord-341050-hnuogpqn	132	29	targeting	target	VBG
cord-341050-hnuogpqn	132	30	both	both	DT
cord-341050-hnuogpqn	132	31	viral	viral	JJ
cord-341050-hnuogpqn	132	32	replication	replication	NN
cord-341050-hnuogpqn	132	33	and	and	CC
cord-341050-hnuogpqn	132	34	the	the	DT
cord-341050-hnuogpqn	132	35	host	host	NN
cord-341050-hnuogpqn	132	36	cell	cell	NN
cord-341050-hnuogpqn	132	37	metabolism	metabolism	NN
cord-341050-hnuogpqn	132	38	.	.	.
cord-341050-hnuogpqn	133	1	The	the	DT
cord-341050-hnuogpqn	133	2	development	development	NN
cord-341050-hnuogpqn	133	3	of	of	IN
cord-341050-hnuogpqn	133	4	an	an	DT
cord-341050-hnuogpqn	133	5	antiviral	antiviral	JJ
cord-341050-hnuogpqn	133	6	drug	drug	NN
cord-341050-hnuogpqn	133	7	is	be	VBZ
cord-341050-hnuogpqn	133	8	a	a	DT
cord-341050-hnuogpqn	133	9	multistep	multistep	JJ
cord-341050-hnuogpqn	133	10	process	process	NN
cord-341050-hnuogpqn	133	11	that	that	WDT
cord-341050-hnuogpqn	133	12	takes	take	VBZ
cord-341050-hnuogpqn	133	13	years	year	NNS
cord-341050-hnuogpqn	133	14	before	before	IN
cord-341050-hnuogpqn	133	15	it	-PRON-	PRP
cord-341050-hnuogpqn	133	16	reaches	reach	VBZ
cord-341050-hnuogpqn	133	17	the	the	DT
cord-341050-hnuogpqn	133	18	market	market	NN
cord-341050-hnuogpqn	133	19	.	.	.
cord-341050-hnuogpqn	134	1	A	a	DT
cord-341050-hnuogpqn	134	2	general	general	JJ
cord-341050-hnuogpqn	134	3	overview	overview	NN
cord-341050-hnuogpqn	134	4	of	of	IN
cord-341050-hnuogpqn	134	5	a	a	DT
cord-341050-hnuogpqn	134	6	drug	drug	NN
cord-341050-hnuogpqn	134	7	development	development	NN
cord-341050-hnuogpqn	134	8	process	process	NN
cord-341050-hnuogpqn	134	9	is	be	VBZ
cord-341050-hnuogpqn	134	10	outlined	outline	VBN
cord-341050-hnuogpqn	134	11	in	in	IN
cord-341050-hnuogpqn	134	12	Fig	Fig	NNP
cord-341050-hnuogpqn	134	13	.	.	NNP
cord-341050-hnuogpqn	134	14	2	2	CD
cord-341050-hnuogpqn	134	15	.	.	.
cord-341050-hnuogpqn	135	1	Hit	hit	VB
cord-341050-hnuogpqn	135	2	-	-	HYPH
cord-341050-hnuogpqn	135	3	to	to	IN
cord-341050-hnuogpqn	135	4	-	-	HYPH
cord-341050-hnuogpqn	135	5	lead	lead	NN
cord-341050-hnuogpqn	135	6	is	be	VBZ
cord-341050-hnuogpqn	135	7	an	an	DT
cord-341050-hnuogpqn	135	8	initial	initial	JJ
cord-341050-hnuogpqn	135	9	stage	stage	NN
cord-341050-hnuogpqn	135	10	in	in	IN
cord-341050-hnuogpqn	135	11	a	a	DT
cord-341050-hnuogpqn	135	12	drug	drug	NN
cord-341050-hnuogpqn	135	13	discovery	discovery	NN
cord-341050-hnuogpqn	135	14	,	,	,
cord-341050-hnuogpqn	135	15	where	where	WRB
cord-341050-hnuogpqn	135	16	small	small	JJ
cord-341050-hnuogpqn	135	17	molecule	molecule	NN
cord-341050-hnuogpqn	135	18	hits	hit	NNS
cord-341050-hnuogpqn	135	19	are	be	VBP
cord-341050-hnuogpqn	135	20	screened	screen	VBN
cord-341050-hnuogpqn	135	21	and	and	CC
cord-341050-hnuogpqn	135	22	further	further	RB
cord-341050-hnuogpqn	135	23	evaluated	evaluate	VBN
cord-341050-hnuogpqn	135	24	to	to	TO
cord-341050-hnuogpqn	135	25	identify	identify	VB
cord-341050-hnuogpqn	135	26	promising	promising	JJ
cord-341050-hnuogpqn	135	27	lead	lead	JJ
cord-341050-hnuogpqn	135	28	compounds	compound	NNS
cord-341050-hnuogpqn	135	29	with	with	IN
cord-341050-hnuogpqn	135	30	a	a	DT
cord-341050-hnuogpqn	135	31	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	135	32	potential	potential	NN
cord-341050-hnuogpqn	135	33	.	.	.
cord-341050-hnuogpqn	136	1	Recent	recent	JJ
cord-341050-hnuogpqn	136	2	progress	progress	NN
cord-341050-hnuogpqn	136	3	in	in	IN
cord-341050-hnuogpqn	136	4	the	the	DT
cord-341050-hnuogpqn	136	5	development	development	NN
cord-341050-hnuogpqn	136	6	of	of	IN
cord-341050-hnuogpqn	136	7	multiple	multiple	JJ
cord-341050-hnuogpqn	136	8	approaches	approach	NNS
cord-341050-hnuogpqn	136	9	for	for	IN
cord-341050-hnuogpqn	136	10	designing	design	VBG
cord-341050-hnuogpqn	136	11	,	,	,
cord-341050-hnuogpqn	136	12	screening	screening	NN
cord-341050-hnuogpqn	136	13	,	,	,
cord-341050-hnuogpqn	136	14	identifi	identifi	NNP
cord-341050-hnuogpqn	136	15	cation	cation	NNP
cord-341050-hnuogpqn	136	16	,	,	,
cord-341050-hnuogpqn	136	17	and	and	CC
cord-341050-hnuogpqn	136	18	validation	validation	NN
cord-341050-hnuogpqn	136	19	of	of	IN
cord-341050-hnuogpqn	136	20	hit	hit	NN
cord-341050-hnuogpqn	136	21	compound	compound	NN
cord-341050-hnuogpqn	136	22	(	(	-LRB-
cord-341050-hnuogpqn	136	23	reviewed	review	VBN
cord-341050-hnuogpqn	136	24	by	by	IN
cord-341050-hnuogpqn	136	25	[	[	-LRB-
cord-341050-hnuogpqn	136	26	194	194	CD
cord-341050-hnuogpqn	136	27	-199	-199	NNS
cord-341050-hnuogpqn	136	28	]	]	-RRB-
cord-341050-hnuogpqn	136	29	)	)	-RRB-
cord-341050-hnuogpqn	136	30	have	have	VBP
cord-341050-hnuogpqn	136	31	witnessed	witness	VBN
cord-341050-hnuogpqn	136	32	growing	grow	VBG
cord-341050-hnuogpqn	136	33	interests	interest	NNS
cord-341050-hnuogpqn	136	34	in	in	IN
cord-341050-hnuogpqn	136	35	the	the	DT
cord-341050-hnuogpqn	136	36	fi	fi	NNP
cord-341050-hnuogpqn	136	37	eld	eld	NN
cord-341050-hnuogpqn	136	38	of	of	IN
cord-341050-hnuogpqn	136	39	drug	drug	NN
cord-341050-hnuogpqn	136	40	development	development	NN
cord-341050-hnuogpqn	136	41	.	.	.
cord-341050-hnuogpqn	137	1	Signifi	Signifi	NNP
cord-341050-hnuogpqn	137	2	ca	can	MD
cord-341050-hnuogpqn	137	3	nt	not	RB
cord-341050-hnuogpqn	137	4	progress	progress	VB
cord-341050-hnuogpqn	137	5	in	in	IN
cord-341050-hnuogpqn	137	6	structural	structural	JJ
cord-341050-hnuogpqn	137	7	and	and	CC
cord-341050-hnuogpqn	137	8	functional	functional	JJ
cord-341050-hnuogpqn	137	9	characterization	characterization	NN
cord-341050-hnuogpqn	137	10	of	of	IN
cord-341050-hnuogpqn	137	11	both	both	DT
cord-341050-hnuogpqn	137	12	structural	structural	JJ
cord-341050-hnuogpqn	137	13	and	and	CC
cord-341050-hnuogpqn	137	14	nonstructural	nonstructural	JJ
cord-341050-hnuogpqn	137	15	proteins	protein	NNS
cord-341050-hnuogpqn	137	16	of	of	IN
cord-341050-hnuogpqn	137	17	WNV	WNV	NNP
cord-341050-hnuogpqn	137	18	and	and	CC
cord-341050-hnuogpqn	137	19	other	other	JJ
cord-341050-hnuogpqn	137	20	fl	fl	NNP
cord-341050-hnuogpqn	137	21	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	137	22	has	have	VBZ
cord-341050-hnuogpqn	137	23	facilitated	facilitate	VBN
cord-341050-hnuogpqn	137	24	identifi	identifi	NNP
cord-341050-hnuogpqn	137	25	cation	cation	NN
cord-341050-hnuogpqn	137	26	of	of	IN
cord-341050-hnuogpqn	137	27	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	137	28	targets	target	NNS
cord-341050-hnuogpqn	137	29	and	and	CC
cord-341050-hnuogpqn	137	30	hit	hit	VB
cord-341050-hnuogpqn	137	31	-	-	HYPH
cord-341050-hnuogpqn	137	32	to	to	IN
cord-341050-hnuogpqn	137	33	-	-	HYPH
cord-341050-hnuogpqn	137	34	lead	lead	NN
cord-341050-hnuogpqn	137	35	screening	screening	NN
cord-341050-hnuogpqn	137	36	.	.	.
cord-341050-hnuogpqn	138	1	For	for	IN
cord-341050-hnuogpqn	138	2	example	example	NN
cord-341050-hnuogpqn	138	3	,	,	,
cord-341050-hnuogpqn	138	4	characterization	characterization	NN
cord-341050-hnuogpqn	138	5	of	of	IN
cord-341050-hnuogpqn	138	6	pseudo	pseudo	JJ
cord-341050-hnuogpqn	138	7	-	-	JJ
cord-341050-hnuogpqn	138	8	atomic	atomic	JJ
cord-341050-hnuogpqn	138	9	structure	structure	NN
cord-341050-hnuogpqn	138	10	of	of	IN
cord-341050-hnuogpqn	138	11	mature	mature	JJ
cord-341050-hnuogpqn	138	12	and	and	CC
cord-341050-hnuogpqn	138	13	immature	immature	JJ
cord-341050-hnuogpqn	138	14	WNV	WNV	NNP
cord-341050-hnuogpqn	138	15	[	[	-LRB-
cord-341050-hnuogpqn	138	16	35	35	CD
cord-341050-hnuogpqn	138	17	]	]	-RRB-
cord-341050-hnuogpqn	138	18	,	,	,
cord-341050-hnuogpqn	138	19	atomic	atomic	JJ
cord-341050-hnuogpqn	138	20	resolution	resolution	NN
cord-341050-hnuogpqn	138	21	structure	structure	NN
cord-341050-hnuogpqn	138	22	of	of	IN
cord-341050-hnuogpqn	138	23	WNV	WNV	NNP
cord-341050-hnuogpqn	138	24	and	and	CC
cord-341050-hnuogpqn	138	25	other	other	JJ
cord-341050-hnuogpqn	138	26	fl	fl	NNP
cord-341050-hnuogpqn	138	27	aviviral	aviviral	JJ
cord-341050-hnuogpqn	138	28	protein	protein	NN
cord-341050-hnuogpqn	138	29	by	by	IN
cord-341050-hnuogpqn	138	30	X	x	NN
cord-341050-hnuogpqn	138	31	-	-	NN
cord-341050-hnuogpqn	138	32	ray	ray	NN
cord-341050-hnuogpqn	138	33	crystallography	crystallography	NN
cord-341050-hnuogpqn	138	34	and	and	CC
cord-341050-hnuogpqn	138	35	nuclear	nuclear	JJ
cord-341050-hnuogpqn	138	36	magnetic	magnetic	JJ
cord-341050-hnuogpqn	138	37	resonance	resonance	NN
cord-341050-hnuogpqn	138	38	(	(	-LRB-
cord-341050-hnuogpqn	138	39	NMR	NMR	NNP
cord-341050-hnuogpqn	138	40	)	)	-RRB-
cord-341050-hnuogpqn	138	41	spectroscopy	spectroscopy	NN
cord-341050-hnuogpqn	138	42	[	[	-LRB-
cord-341050-hnuogpqn	138	43	39	39	CD
cord-341050-hnuogpqn	138	44	,	,	,
cord-341050-hnuogpqn	138	45	41	41	CD
cord-341050-hnuogpqn	138	46	,	,	,
cord-341050-hnuogpqn	138	47	48	48	CD
cord-341050-hnuogpqn	138	48	,	,	,
cord-341050-hnuogpqn	138	49	200	200	CD
cord-341050-hnuogpqn	138	50	-203	-203	JJ
cord-341050-hnuogpqn	138	51	]	]	-RRB-
cord-341050-hnuogpqn	138	52	,	,	,
cord-341050-hnuogpqn	138	53	and	and	CC
cord-341050-hnuogpqn	138	54	structural	structural	JJ
cord-341050-hnuogpqn	138	55	characterization	characterization	NN
cord-341050-hnuogpqn	138	56	of	of	IN
cord-341050-hnuogpqn	138	57	binding	bind	VBG
cord-341050-hnuogpqn	138	58	of	of	IN
cord-341050-hnuogpqn	138	59	a	a	DT
cord-341050-hnuogpqn	138	60	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	138	61	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	138	62	antibody	antibody	NN
cord-341050-hnuogpqn	138	63	to	to	TO
cord-341050-hnuogpqn	138	64	E	e	NN
cord-341050-hnuogpqn	138	65	protein	protein	NN
cord-341050-hnuogpqn	138	66	of	of	IN
cord-341050-hnuogpqn	138	67	WNV	WNV	NNP
cord-341050-hnuogpqn	138	68	[	[	-LRB-
cord-341050-hnuogpqn	138	69	48	48	CD
cord-341050-hnuogpqn	138	70	]	]	-RRB-
cord-341050-hnuogpqn	138	71	have	have	VBP
cord-341050-hnuogpqn	138	72	greatly	greatly	RB
cord-341050-hnuogpqn	138	73	increased	increase	VBN
cord-341050-hnuogpqn	138	74	our	-PRON-	PRP$
cord-341050-hnuogpqn	138	75	understanding	understanding	NN
cord-341050-hnuogpqn	138	76	of	of	IN
cord-341050-hnuogpqn	138	77	both	both	DT
cord-341050-hnuogpqn	138	78	structural	structural	JJ
cord-341050-hnuogpqn	138	79	and	and	CC
cord-341050-hnuogpqn	138	80	functional	functional	JJ
cord-341050-hnuogpqn	138	81	aspects	aspect	NNS
cord-341050-hnuogpqn	138	82	of	of	IN
cord-341050-hnuogpqn	138	83	potential	potential	JJ
cord-341050-hnuogpqn	138	84	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	138	85	targets	target	NNS
cord-341050-hnuogpqn	138	86	.	.	.
cord-341050-hnuogpqn	139	1	Two	two	CD
cord-341050-hnuogpqn	139	2	approaches	approach	NNS
cord-341050-hnuogpqn	139	3	have	have	VBP
cord-341050-hnuogpqn	139	4	been	be	VBN
cord-341050-hnuogpqn	139	5	commonly	commonly	RB
cord-341050-hnuogpqn	139	6	used	use	VBN
cord-341050-hnuogpqn	139	7	for	for	IN
cord-341050-hnuogpqn	139	8	small	small	JJ
cord-341050-hnuogpqn	139	9	molecule	molecule	NN
cord-341050-hnuogpqn	139	10	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	139	11	screening	screening	NN
cord-341050-hnuogpqn	139	12	include	include	VBP
cord-341050-hnuogpqn	139	13	target	target	NN
cord-341050-hnuogpqn	139	14	-	-	HYPH
cord-341050-hnuogpqn	139	15	based	base	VBN
cord-341050-hnuogpqn	139	16	approach	approach	NN
cord-341050-hnuogpqn	139	17	and	and	CC
cord-341050-hnuogpqn	139	18	cell	cell	NN
cord-341050-hnuogpqn	139	19	-	-	HYPH
cord-341050-hnuogpqn	139	20	based	base	VBN
cord-341050-hnuogpqn	139	21	approach	approach	NN
cord-341050-hnuogpqn	139	22	.	.	.
cord-341050-hnuogpqn	140	1	For	for	IN
cord-341050-hnuogpqn	140	2	target	target	NN
cord-341050-hnuogpqn	140	3	-	-	HYPH
cord-341050-hnuogpqn	140	4	based	base	VBN
cord-341050-hnuogpqn	140	5	screening	screening	NN
cord-341050-hnuogpqn	140	6	,	,	,
cord-341050-hnuogpqn	140	7	several	several	JJ
cord-341050-hnuogpqn	140	8	methods	method	NNS
cord-341050-hnuogpqn	140	9	can	can	MD
cord-341050-hnuogpqn	140	10	be	be	VB
cord-341050-hnuogpqn	140	11	applied	apply	VBN
cord-341050-hnuogpqn	140	12	,	,	,
cord-341050-hnuogpqn	140	13	including	include	VBG
cord-341050-hnuogpqn	140	14	enzyme	enzyme	NN
cord-341050-hnuogpqn	140	15	activity	activity	NN
cord-341050-hnuogpqn	140	16	-	-	HYPH
cord-341050-hnuogpqn	140	17	based	base	VBN
cord-341050-hnuogpqn	140	18	screening	screening	NN
cord-341050-hnuogpqn	140	19	,	,	,
cord-341050-hnuogpqn	140	20	fragmentbased	fragmentbased	JJ
cord-341050-hnuogpqn	140	21	screening	screening	NN
cord-341050-hnuogpqn	140	22	,	,	,
cord-341050-hnuogpqn	140	23	affi	affi	NNP
cord-341050-hnuogpqn	140	24	nity	nity	NN
cord-341050-hnuogpqn	140	25	-	-	HYPH
cord-341050-hnuogpqn	140	26	based	base	VBN
cord-341050-hnuogpqn	140	27	screening	screening	NN
cord-341050-hnuogpqn	140	28	,	,	,
cord-341050-hnuogpqn	140	29	structure	structure	NN
cord-341050-hnuogpqn	140	30	-	-	HYPH
cord-341050-hnuogpqn	140	31	based	base	VBN
cord-341050-hnuogpqn	140	32	rational	rational	JJ
cord-341050-hnuogpqn	140	33	[	[	-LRB-
cord-341050-hnuogpqn	140	34	197	197	CD
cord-341050-hnuogpqn	140	35	,	,	,
cord-341050-hnuogpqn	140	36	198	198	CD
cord-341050-hnuogpqn	140	37	,	,	,
cord-341050-hnuogpqn	140	38	204	204	CD
cord-341050-hnuogpqn	140	39	-207	-207	NN
cord-341050-hnuogpqn	140	40	]	]	-RRB-
cord-341050-hnuogpqn	140	41	.	.	.
cord-341050-hnuogpqn	141	1	In	in	IN
cord-341050-hnuogpqn	141	2	contrast	contrast	NN
cord-341050-hnuogpqn	141	3	,	,	,
cord-341050-hnuogpqn	141	4	cell	cell	NN
cord-341050-hnuogpqn	141	5	-	-	HYPH
cord-341050-hnuogpqn	141	6	based	base	VBN
cord-341050-hnuogpqn	141	7	approaches	approach	NNS
cord-341050-hnuogpqn	141	8	use	use	VBP
cord-341050-hnuogpqn	141	9	viral	viral	JJ
cord-341050-hnuogpqn	141	10	infection	infection	NN
cord-341050-hnuogpqn	141	11	and	and	CC
cord-341050-hnuogpqn	141	12	replication	replication	NN
cord-341050-hnuogpqn	141	13	-dependent	-dependent	VBN
cord-341050-hnuogpqn	141	14	assays	assay	NNS
cord-341050-hnuogpqn	141	15	to	to	TO
cord-341050-hnuogpqn	141	16	identify	identify	VB
cord-341050-hnuogpqn	141	17	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	141	18	[	[	-LRB-
cord-341050-hnuogpqn	141	19	208	208	CD
cord-341050-hnuogpqn	141	20	]	]	-RRB-
cord-341050-hnuogpqn	141	21	.	.	.
cord-341050-hnuogpqn	142	1	Each	each	DT
cord-341050-hnuogpqn	142	2	of	of	IN
cord-341050-hnuogpqn	142	3	these	these	DT
cord-341050-hnuogpqn	142	4	approaches	approach	NNS
cord-341050-hnuogpqn	142	5	presents	present	VBZ
cord-341050-hnuogpqn	142	6	their	-PRON-	PRP$
cord-341050-hnuogpqn	142	7	unique	unique	JJ
cord-341050-hnuogpqn	142	8	sets	set	NNS
cord-341050-hnuogpqn	142	9	of	of	IN
cord-341050-hnuogpqn	142	10	merits	merit	NNS
cord-341050-hnuogpqn	142	11	and	and	CC
cord-341050-hnuogpqn	142	12	challenges	challenge	NNS
cord-341050-hnuogpqn	142	13	.	.	.
cord-341050-hnuogpqn	143	1	For	for	IN
cord-341050-hnuogpqn	143	2	instance	instance	NN
cord-341050-hnuogpqn	143	3	,	,	,
cord-341050-hnuogpqn	143	4	it	-PRON-	PRP
cord-341050-hnuogpqn	143	5	is	be	VBZ
cord-341050-hnuogpqn	143	6	generally	generally	RB
cord-341050-hnuogpqn	143	7	diffi	diffi	JJ
cord-341050-hnuogpqn	143	8	cult	cult	NN
cord-341050-hnuogpqn	143	9	to	to	TO
cord-341050-hnuogpqn	143	10	identify	identify	VB
cord-341050-hnuogpqn	143	11	a	a	DT
cord-341050-hnuogpqn	143	12	target	target	NN
cord-341050-hnuogpqn	143	13	and	and	CC
cord-341050-hnuogpqn	143	14	also	also	RB
cord-341050-hnuogpqn	143	15	achieve	achieve	VB
cord-341050-hnuogpqn	143	16	specifi	specifi	VBN
cord-341050-hnuogpqn	143	17	city	city	NN
cord-341050-hnuogpqn	143	18	by	by	IN
cord-341050-hnuogpqn	143	19	cell	cell	NN
cord-341050-hnuogpqn	143	20	-	-	HYPH
cord-341050-hnuogpqn	143	21	based	base	VBN
cord-341050-hnuogpqn	143	22	assay	assay	NN
cord-341050-hnuogpqn	143	23	because	because	IN
cord-341050-hnuogpqn	143	24	such	such	JJ
cord-341050-hnuogpqn	143	25	identifi	identifi	NNS
cord-341050-hnuogpqn	143	26	ed	ed	NNP
cord-341050-hnuogpqn	143	27	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	143	28	may	may	MD
cord-341050-hnuogpqn	143	29	potentially	potentially	RB
cord-341050-hnuogpqn	143	30	affect	affect	VB
cord-341050-hnuogpqn	143	31	multiple	multiple	JJ
cord-341050-hnuogpqn	143	32	steps	step	NNS
cord-341050-hnuogpqn	143	33	of	of	IN
cord-341050-hnuogpqn	143	34	viral	viral	JJ
cord-341050-hnuogpqn	143	35	infection	infection	NN
cord-341050-hnuogpqn	143	36	cycles	cycle	NNS
cord-341050-hnuogpqn	143	37	and	and	CC
cord-341050-hnuogpqn	143	38	may	may	MD
cord-341050-hnuogpqn	143	39	target	target	VB
cord-341050-hnuogpqn	143	40	both	both	DT
cord-341050-hnuogpqn	143	41	viral	viral	JJ
cord-341050-hnuogpqn	143	42	and	and	CC
cord-341050-hnuogpqn	143	43	host	host	NN
cord-341050-hnuogpqn	143	44	proteins	protein	NNS
cord-341050-hnuogpqn	143	45	.	.	.
cord-341050-hnuogpqn	144	1	Although	although	IN
cord-341050-hnuogpqn	144	2	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	144	3	identifi	identifi	NNP
cord-341050-hnuogpqn	144	4	ed	ed	NN
cord-341050-hnuogpqn	144	5	by	by	IN
cord-341050-hnuogpqn	144	6	cell	cell	NN
cord-341050-hnuogpqn	144	7	-	-	HYPH
cord-341050-hnuogpqn	144	8	based	base	VBN
cord-341050-hnuogpqn	144	9	assay	assay	NN
cord-341050-hnuogpqn	144	10	may	may	MD
cord-341050-hnuogpqn	144	11	prove	prove	VB
cord-341050-hnuogpqn	144	12	useful	useful	JJ
cord-341050-hnuogpqn	144	13	as	as	IN
cord-341050-hnuogpqn	144	14	antiviral	antiviral	JJ
cord-341050-hnuogpqn	144	15	drug	drug	NN
cord-341050-hnuogpqn	144	16	candidates	candidate	NNS
cord-341050-hnuogpqn	144	17	,	,	,
cord-341050-hnuogpqn	144	18	these	these	DT
cord-341050-hnuogpqn	144	19	compounds	compound	NNS
cord-341050-hnuogpqn	144	20	could	could	MD
cord-341050-hnuogpqn	144	21	also	also	RB
cord-341050-hnuogpqn	144	22	act	act	VB
cord-341050-hnuogpqn	144	23	nonspecifi	nonspecifi	NNP
cord-341050-hnuogpqn	144	24	cally	cally	RB
cord-341050-hnuogpqn	144	25	;	;	:
cord-341050-hnuogpqn	144	26	thus	thus	RB
cord-341050-hnuogpqn	144	27	further	further	JJ
cord-341050-hnuogpqn	144	28	elucidation	elucidation	NN
cord-341050-hnuogpqn	144	29	of	of	IN
cord-341050-hnuogpqn	144	30	their	-PRON-	PRP$
cord-341050-hnuogpqn	144	31	mechanism	mechanism	NN
cord-341050-hnuogpqn	144	32	of	of	IN
cord-341050-hnuogpqn	144	33	action	action	NN
cord-341050-hnuogpqn	144	34	is	be	VBZ
cord-341050-hnuogpqn	144	35	required	require	VBN
cord-341050-hnuogpqn	144	36	.	.	.
cord-341050-hnuogpqn	145	1	The	the	DT
cord-341050-hnuogpqn	145	2	target	target	NN
cord-341050-hnuogpqn	145	3	-	-	HYPH
cord-341050-hnuogpqn	145	4	based	base	VBN
cord-341050-hnuogpqn	145	5	approaches	approach	NNS
cord-341050-hnuogpqn	145	6	are	be	VBP
cord-341050-hnuogpqn	145	7	highly	highly	RB
cord-341050-hnuogpqn	145	8	effi	effi	JJ
cord-341050-hnuogpqn	145	9	cient	cient	NN
cord-341050-hnuogpqn	145	10	in	in	IN
cord-341050-hnuogpqn	145	11	screening	screening	NN
cord-341050-hnuogpqn	145	12	process	process	NN
cord-341050-hnuogpqn	145	13	,	,	,
cord-341050-hnuogpqn	145	14	however	however	RB
cord-341050-hnuogpqn	145	15	,	,	,
cord-341050-hnuogpqn	145	16	an	an	DT
cord-341050-hnuogpqn	145	17	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	145	18	screened	screen	VBN
cord-341050-hnuogpqn	145	19	by	by	IN
cord-341050-hnuogpqn	145	20	such	such	JJ
cord-341050-hnuogpqn	145	21	method	method	NN
cord-341050-hnuogpqn	145	22	may	may	MD
cord-341050-hnuogpqn	145	23	require	require	VB
cord-341050-hnuogpqn	145	24	further	further	JJ
cord-341050-hnuogpqn	145	25	modifi	modifi	JJ
cord-341050-hnuogpqn	145	26	cation	cation	NN
cord-341050-hnuogpqn	145	27	for	for	IN
cord-341050-hnuogpqn	145	28	effective	effective	JJ
cord-341050-hnuogpqn	145	29	cellular	cellular	JJ
cord-341050-hnuogpqn	145	30	permeability	permeability	NN
cord-341050-hnuogpqn	145	31	and	and	CC
cord-341050-hnuogpqn	145	32	validation	validation	NN
cord-341050-hnuogpqn	145	33	for	for	IN
cord-341050-hnuogpqn	145	34	its	-PRON-	PRP$
cord-341050-hnuogpqn	145	35	antiviral	antiviral	JJ
cord-341050-hnuogpqn	145	36	activity	activity	NN
cord-341050-hnuogpqn	145	37	,	,	,
cord-341050-hnuogpqn	145	38	selectivity	selectivity	NN
cord-341050-hnuogpqn	145	39	and	and	CC
cord-341050-hnuogpqn	145	40	toxicity	toxicity	NN
cord-341050-hnuogpqn	145	41	by	by	IN
cord-341050-hnuogpqn	145	42	using	use	VBG
cord-341050-hnuogpqn	145	43	cell	cell	NN
cord-341050-hnuogpqn	145	44	-	-	HYPH
cord-341050-hnuogpqn	145	45	based	base	VBN
cord-341050-hnuogpqn	145	46	assays	assay	NNS
cord-341050-hnuogpqn	145	47	.	.	.
cord-341050-hnuogpqn	146	1	In	in	IN
cord-341050-hnuogpqn	146	2	the	the	DT
cord-341050-hnuogpqn	146	3	fi	fi	NN
cord-341050-hnuogpqn	146	4	nal	nal	FW
cord-341050-hnuogpqn	146	5	stages	stage	NNS
cord-341050-hnuogpqn	146	6	,	,	,
cord-341050-hnuogpqn	146	7	lead	lead	JJ
cord-341050-hnuogpqn	146	8	compounds	compound	NNS
cord-341050-hnuogpqn	146	9	are	be	VBP
cord-341050-hnuogpqn	146	10	selected	select	VBN
cord-341050-hnuogpqn	146	11	for	for	IN
cord-341050-hnuogpqn	146	12	in	in	FW
cord-341050-hnuogpqn	146	13	vitro	vitro	FW
cord-341050-hnuogpqn	146	14	and	and	CC
cord-341050-hnuogpqn	146	15	in	in	IN
cord-341050-hnuogpqn	146	16	vivo	vivo	FW
cord-341050-hnuogpqn	146	17	pharmacokinetic	pharmacokinetic	JJ
cord-341050-hnuogpqn	146	18	profi	profi	NNP
cord-341050-hnuogpqn	146	19	ling	ling	NNP
cord-341050-hnuogpqn	146	20	,	,	,
cord-341050-hnuogpqn	146	21	including	include	VBG
cord-341050-hnuogpqn	146	22	effi	effi	NNP
cord-341050-hnuogpqn	146	23	cacy	cacy	NNP
cord-341050-hnuogpqn	146	24	,	,	,
cord-341050-hnuogpqn	146	25	plasma	plasma	NN
cord-341050-hnuogpqn	146	26	stability	stability	NN
cord-341050-hnuogpqn	146	27	(	(	-LRB-
cord-341050-hnuogpqn	146	28	halflife	halflife	NNP
cord-341050-hnuogpqn	146	29	)	)	-RRB-
cord-341050-hnuogpqn	146	30	,	,	,
cord-341050-hnuogpqn	146	31	exposure	exposure	NN
cord-341050-hnuogpqn	146	32	,	,	,
cord-341050-hnuogpqn	146	33	bioavailability	bioavailability	NN
cord-341050-hnuogpqn	146	34	,	,	,
cord-341050-hnuogpqn	146	35	and	and	CC
cord-341050-hnuogpqn	146	36	preclinical	preclinical	JJ
cord-341050-hnuogpqn	146	37	toxicity	toxicity	NN
cord-341050-hnuogpqn	146	38	before	before	IN
cord-341050-hnuogpqn	146	39	planning	plan	VBG
cord-341050-hnuogpqn	146	40	a	a	DT
cord-341050-hnuogpqn	146	41	clinical	clinical	JJ
cord-341050-hnuogpqn	146	42	trial	trial	NN
cord-341050-hnuogpqn	146	43	.	.	.
cord-341050-hnuogpqn	147	1	The	the	DT
cord-341050-hnuogpqn	147	2	most	most	RBS
cord-341050-hnuogpqn	147	3	common	common	JJ
cord-341050-hnuogpqn	147	4	strategies	strategy	NNS
cord-341050-hnuogpqn	147	5	for	for	IN
cord-341050-hnuogpqn	147	6	antiviral	antiviral	JJ
cord-341050-hnuogpqn	147	7	drug	drug	NN
cord-341050-hnuogpqn	147	8	development	development	NN
cord-341050-hnuogpqn	147	9	include	include	VBP
cord-341050-hnuogpqn	147	10	blocking	block	VBG
cord-341050-hnuogpqn	147	11	virus	virus	NN
cord-341050-hnuogpqn	147	12	attachment	attachment	NN
cord-341050-hnuogpqn	147	13	or	or	CC
cord-341050-hnuogpqn	147	14	entry	entry	NN
cord-341050-hnuogpqn	147	15	into	into	IN
cord-341050-hnuogpqn	147	16	host	host	NN
cord-341050-hnuogpqn	147	17	cells	cell	NNS
cord-341050-hnuogpqn	147	18	and	and	CC
cord-341050-hnuogpqn	147	19	inhibiting	inhibit	VBG
cord-341050-hnuogpqn	147	20	viral	viral	JJ
cord-341050-hnuogpqn	147	21	replication	replication	NN
cord-341050-hnuogpqn	147	22	,	,	,
cord-341050-hnuogpqn	147	23	either	either	CC
cord-341050-hnuogpqn	147	24	by	by	IN
cord-341050-hnuogpqn	147	25	targeting	target	VBG
cord-341050-hnuogpqn	147	26	on	on	IN
cord-341050-hnuogpqn	147	27	viral	viral	JJ
cord-341050-hnuogpqn	147	28	components	component	NNS
cord-341050-hnuogpqn	147	29	or	or	CC
cord-341050-hnuogpqn	147	30	host	host	NN
cord-341050-hnuogpqn	147	31	cells	cell	NNS
cord-341050-hnuogpqn	147	32	metabolism	metabolism	VBP
cord-341050-hnuogpqn	147	33	.	.	.
cord-341050-hnuogpqn	148	1	There	there	EX
cord-341050-hnuogpqn	148	2	has	have	VBZ
cord-341050-hnuogpqn	148	3	been	be	VBN
cord-341050-hnuogpqn	148	4	a	a	DT
cord-341050-hnuogpqn	148	5	signifi	signifi	NN
cord-341050-hnuogpqn	148	6	ca	can	MD
cord-341050-hnuogpqn	148	7	nt	not	RB
cord-341050-hnuogpqn	148	8	progress	progress	VB
cord-341050-hnuogpqn	148	9	in	in	IN
cord-341050-hnuogpqn	148	10	development	development	NN
cord-341050-hnuogpqn	148	11	and	and	CC
cord-341050-hnuogpqn	148	12	testing	testing	NN
cord-341050-hnuogpqn	148	13	of	of	IN
cord-341050-hnuogpqn	148	14	potential	potential	JJ
cord-341050-hnuogpqn	148	15	antivirals	antiviral	NNS
cord-341050-hnuogpqn	148	16	against	against	IN
cord-341050-hnuogpqn	148	17	fl	fl	NNP
cord-341050-hnuogpqn	148	18	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	148	19	including	include	VBG
cord-341050-hnuogpqn	148	20	WNV	WNV	NNP
cord-341050-hnuogpqn	148	21	(	(	-LRB-
cord-341050-hnuogpqn	148	22	reviewed	review	VBN
cord-341050-hnuogpqn	148	23	by	by	IN
cord-341050-hnuogpqn	148	24	[	[	-LRB-
cord-341050-hnuogpqn	148	25	34	34	CD
cord-341050-hnuogpqn	148	26	,	,	,
cord-341050-hnuogpqn	148	27	209	209	CD
cord-341050-hnuogpqn	148	28	,	,	,
cord-341050-hnuogpqn	148	29	210	210	CD
cord-341050-hnuogpqn	148	30	]	]	-RRB-
cord-341050-hnuogpqn	148	31	)	)	-RRB-
cord-341050-hnuogpqn	148	32	.	.	.
cord-341050-hnuogpqn	149	1	Several	several	JJ
cord-341050-hnuogpqn	149	2	natural	natural	JJ
cord-341050-hnuogpqn	149	3	and	and	CC
cord-341050-hnuogpqn	149	4	synthetic	synthetic	JJ
cord-341050-hnuogpqn	149	5	compounds	compound	NNS
cord-341050-hnuogpqn	149	6	,	,	,
cord-341050-hnuogpqn	149	7	antiviral	antiviral	JJ
cord-341050-hnuogpqn	149	8	peptides	peptide	NNS
cord-341050-hnuogpqn	149	9	and	and	CC
cord-341050-hnuogpqn	149	10	siRNAs	siRNAs	NNP
cord-341050-hnuogpqn	149	11	have	have	VBP
cord-341050-hnuogpqn	149	12	been	be	VBN
cord-341050-hnuogpqn	149	13	identifi	identifi	VBN
cord-341050-hnuogpqn	149	14	ed	ed	NN
cord-341050-hnuogpqn	149	15	to	to	TO
cord-341050-hnuogpqn	149	16	target	target	VB
cord-341050-hnuogpqn	149	17	both	both	DT
cord-341050-hnuogpqn	149	18	structural	structural	JJ
cord-341050-hnuogpqn	149	19	and	and	CC
cord-341050-hnuogpqn	149	20	nonstructural	nonstructural	JJ
cord-341050-hnuogpqn	149	21	proteins	protein	NNS
cord-341050-hnuogpqn	149	22	of	of	IN
cord-341050-hnuogpqn	149	23	WNV	WNV	NNP
cord-341050-hnuogpqn	149	24	and	and	CC
cord-341050-hnuogpqn	149	25	evaluated	evaluate	VBD
cord-341050-hnuogpqn	149	26	for	for	IN
cord-341050-hnuogpqn	149	27	their	-PRON-	PRP$
cord-341050-hnuogpqn	149	28	potential	potential	JJ
cord-341050-hnuogpqn	149	29	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	149	30	roles	role	NNS
cord-341050-hnuogpqn	149	31	.	.	.
cord-341050-hnuogpqn	150	1	Other	other	JJ
cord-341050-hnuogpqn	150	2	approaches	approach	NNS
cord-341050-hnuogpqn	150	3	include	include	VBP
cord-341050-hnuogpqn	150	4	targeting	target	VBG
cord-341050-hnuogpqn	150	5	host	host	NN
cord-341050-hnuogpqn	150	6	cell	cell	NN
cord-341050-hnuogpqn	150	7	metabolism	metabolism	NN
cord-341050-hnuogpqn	150	8	and	and	CC
cord-341050-hnuogpqn	150	9	physiology	physiology	NN
cord-341050-hnuogpqn	150	10	and	and	CC
cord-341050-hnuogpqn	150	11	modulating	modulate	VBG
cord-341050-hnuogpqn	150	12	host	host	NN
cord-341050-hnuogpqn	150	13	immune	immune	JJ
cord-341050-hnuogpqn	150	14	system	system	NN
cord-341050-hnuogpqn	150	15	by	by	IN
cord-341050-hnuogpqn	150	16	using	use	VBG
cord-341050-hnuogpqn	150	17	antiviral	antiviral	JJ
cord-341050-hnuogpqn	150	18	cytokines	cytokine	NNS
cord-341050-hnuogpqn	150	19	as	as	IN
cord-341050-hnuogpqn	150	20	potential	potential	JJ
cord-341050-hnuogpqn	150	21	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	150	22	against	against	IN
cord-341050-hnuogpqn	150	23	WNV	WNV	NNP
cord-341050-hnuogpqn	150	24	.	.	.
cord-341050-hnuogpqn	151	1	Current	current	JJ
cord-341050-hnuogpqn	151	2	status	status	NN
cord-341050-hnuogpqn	151	3	and	and	CC
cord-341050-hnuogpqn	151	4	strategy	strategy	NN
cord-341050-hnuogpqn	151	5	used	use	VBN
cord-341050-hnuogpqn	151	6	to	to	TO
cord-341050-hnuogpqn	151	7	develop	develop	VB
cord-341050-hnuogpqn	151	8	antiviral	antiviral	JJ
cord-341050-hnuogpqn	151	9	drugs	drug	NNS
cord-341050-hnuogpqn	151	10	targeting	target	VBG
cord-341050-hnuogpqn	151	11	WNV	WNV	NNP
cord-341050-hnuogpqn	151	12	and	and	CC
cord-341050-hnuogpqn	151	13	other	other	JJ
cord-341050-hnuogpqn	151	14	fl	fl	NNP
cord-341050-hnuogpqn	151	15	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	151	16	are	be	VBP
cord-341050-hnuogpqn	151	17	described	describe	VBN
cord-341050-hnuogpqn	151	18	below	below	RB
cord-341050-hnuogpqn	151	19	.	.	.
cord-341050-hnuogpqn	152	1	Several	several	JJ
cord-341050-hnuogpqn	152	2	natural	natural	JJ
cord-341050-hnuogpqn	152	3	and	and	CC
cord-341050-hnuogpqn	152	4	synthetic	synthetic	JJ
cord-341050-hnuogpqn	152	5	compounds	compound	NNS
cord-341050-hnuogpqn	152	6	have	have	VBP
cord-341050-hnuogpqn	152	7	been	be	VBN
cord-341050-hnuogpqn	152	8	identifi	identifi	VBN
cord-341050-hnuogpqn	152	9	ed	ed	NN
cord-341050-hnuogpqn	152	10	to	to	TO
cord-341050-hnuogpqn	152	11	target	target	VB
cord-341050-hnuogpqn	152	12	both	both	DT
cord-341050-hnuogpqn	152	13	structural	structural	JJ
cord-341050-hnuogpqn	152	14	and	and	CC
cord-341050-hnuogpqn	152	15	non	non	JJ
cord-341050-hnuogpqn	152	16	-	-	JJ
cord-341050-hnuogpqn	152	17	structural	structural	JJ
cord-341050-hnuogpqn	152	18	proteins	protein	NNS
cord-341050-hnuogpqn	152	19	of	of	IN
cord-341050-hnuogpqn	152	20	fl	fl	NNP
cord-341050-hnuogpqn	152	21	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	152	22	.	.	.
cord-341050-hnuogpqn	153	1	Most	Most	JJS
cord-341050-hnuogpqn	153	2	of	of	IN
cord-341050-hnuogpqn	153	3	these	these	DT
cord-341050-hnuogpqn	153	4	compounds	compound	NNS
cord-341050-hnuogpqn	153	5	are	be	VBP
cord-341050-hnuogpqn	153	6	designed	design	VBN
cord-341050-hnuogpqn	153	7	to	to	TO
cord-341050-hnuogpqn	153	8	target	target	VB
cord-341050-hnuogpqn	153	9	DENV	DENV	NNP
cord-341050-hnuogpqn	153	10	and	and	CC
cord-341050-hnuogpqn	153	11	some	some	DT
cord-341050-hnuogpqn	153	12	of	of	IN
cord-341050-hnuogpqn	153	13	them	-PRON-	PRP
cord-341050-hnuogpqn	153	14	also	also	RB
cord-341050-hnuogpqn	153	15	show	show	VBP
cord-341050-hnuogpqn	153	16	antiviral	antiviral	JJ
cord-341050-hnuogpqn	153	17	activities	activity	NNS
cord-341050-hnuogpqn	153	18	against	against	IN
cord-341050-hnuogpqn	153	19	WNV	WNV	NNP
cord-341050-hnuogpqn	153	20	and	and	CC
cord-341050-hnuogpqn	153	21	other	other	JJ
cord-341050-hnuogpqn	153	22	fl	fl	NNP
cord-341050-hnuogpqn	153	23	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	153	24	.	.	.
cord-341050-hnuogpqn	154	1	As	as	IN
cord-341050-hnuogpqn	154	2	these	these	DT
cord-341050-hnuogpqn	154	3	compounds	compound	NNS
cord-341050-hnuogpqn	154	4	are	be	VBP
cord-341050-hnuogpqn	154	5	diverse	diverse	JJ
cord-341050-hnuogpqn	154	6	in	in	IN
cord-341050-hnuogpqn	154	7	their	-PRON-	PRP$
cord-341050-hnuogpqn	154	8	chemistry	chemistry	NN
cord-341050-hnuogpqn	154	9	,	,	,
cord-341050-hnuogpqn	154	10	they	-PRON-	PRP
cord-341050-hnuogpqn	154	11	are	be	VBP
cord-341050-hnuogpqn	154	12	discussed	discuss	VBN
cord-341050-hnuogpqn	154	13	below	below	IN
cord-341050-hnuogpqn	154	14	based	base	VBN
cord-341050-hnuogpqn	154	15	on	on	IN
cord-341050-hnuogpqn	154	16	their	-PRON-	PRP$
cord-341050-hnuogpqn	154	17	modes	mode	NNS
cord-341050-hnuogpqn	154	18	of	of	IN
cord-341050-hnuogpqn	154	19	action	action	NN
cord-341050-hnuogpqn	154	20	.	.	.
cord-341050-hnuogpqn	155	1	The	the	DT
cord-341050-hnuogpqn	155	2	E	e	NN
cord-341050-hnuogpqn	155	3	protein	protein	NN
cord-341050-hnuogpqn	155	4	of	of	IN
cord-341050-hnuogpqn	155	5	WNV	WNV	NNP
cord-341050-hnuogpqn	155	6	and	and	CC
cord-341050-hnuogpqn	155	7	other	other	JJ
cord-341050-hnuogpqn	155	8	fl	fl	NNP
cord-341050-hnuogpqn	155	9	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	155	10	play	play	VBP
cord-341050-hnuogpqn	155	11	key	key	JJ
cord-341050-hnuogpqn	155	12	roles	role	NNS
cord-341050-hnuogpqn	155	13	in	in	IN
cord-341050-hnuogpqn	155	14	viral	viral	JJ
cord-341050-hnuogpqn	155	15	entry	entry	NN
cord-341050-hnuogpqn	155	16	into	into	IN
cord-341050-hnuogpqn	155	17	host	host	NN
cord-341050-hnuogpqn	155	18	cells	cell	NNS
cord-341050-hnuogpqn	155	19	by	by	IN
cord-341050-hnuogpqn	155	20	mediating	mediate	VBG
cord-341050-hnuogpqn	155	21	viral	viral	JJ
cord-341050-hnuogpqn	155	22	attachment	attachment	NN
cord-341050-hnuogpqn	155	23	to	to	TO
cord-341050-hnuogpqn	155	24	host	host	VB
cord-341050-hnuogpqn	155	25	cell	cell	NN
cord-341050-hnuogpqn	155	26	receptors	receptor	NNS
cord-341050-hnuogpqn	155	27	and	and	CC
cord-341050-hnuogpqn	155	28	subsequent	subsequent	JJ
cord-341050-hnuogpqn	155	29	membrane	membrane	NN
cord-341050-hnuogpqn	155	30	fusion	fusion	NN
cord-341050-hnuogpqn	155	31	[	[	-LRB-
cord-341050-hnuogpqn	155	32	35	35	CD
cord-341050-hnuogpqn	155	33	,	,	,
cord-341050-hnuogpqn	155	34	41	41	CD
cord-341050-hnuogpqn	155	35	,	,	,
cord-341050-hnuogpqn	155	36	211	211	CD
cord-341050-hnuogpqn	155	37	,	,	,
cord-341050-hnuogpqn	155	38	212	212	CD
cord-341050-hnuogpqn	155	39	]	]	-RRB-
cord-341050-hnuogpqn	155	40	.	.	.
cord-341050-hnuogpqn	156	1	After	after	IN
cord-341050-hnuogpqn	156	2	binding	bind	VBG
cord-341050-hnuogpqn	156	3	to	to	IN
cord-341050-hnuogpqn	156	4	host	host	VB
cord-341050-hnuogpqn	156	5	cell	cell	NN
cord-341050-hnuogpqn	156	6	receptors	receptor	NNS
cord-341050-hnuogpqn	156	7	,	,	,
cord-341050-hnuogpqn	156	8	WNV	WNV	NNP
cord-341050-hnuogpqn	156	9	enters	enter	VBZ
cord-341050-hnuogpqn	156	10	into	into	IN
cord-341050-hnuogpqn	156	11	cells	cell	NNS
cord-341050-hnuogpqn	156	12	through	through	IN
cord-341050-hnuogpqn	156	13	a	a	DT
cord-341050-hnuogpqn	156	14	clathrin	clathrin	NN
cord-341050-hnuogpqn	156	15	-	-	HYPH
cord-341050-hnuogpqn	156	16	independent	independent	JJ
cord-341050-hnuogpqn	156	17	endocytosis	endocytosis	NN
cord-341050-hnuogpqn	156	18	process	process	NN
cord-341050-hnuogpqn	156	19	followed	follow	VBN
cord-341050-hnuogpqn	156	20	by	by	IN
cord-341050-hnuogpqn	156	21	a	a	DT
cord-341050-hnuogpqn	156	22	low	low	JJ
cord-341050-hnuogpqn	156	23	-	-	HYPH
cord-341050-hnuogpqn	156	24	pHdependent	pHdependent	NNP
cord-341050-hnuogpqn	156	25	viral	viral	JJ
cord-341050-hnuogpqn	156	26	uncoating	uncoate	VBG
cord-341050-hnuogpqn	156	27	in	in	IN
cord-341050-hnuogpqn	156	28	the	the	DT
cord-341050-hnuogpqn	156	29	endosome	endosome	NN
cord-341050-hnuogpqn	156	30	to	to	TO
cord-341050-hnuogpqn	156	31	release	release	VB
cord-341050-hnuogpqn	156	32	viral	viral	JJ
cord-341050-hnuogpqn	156	33	genome	genome	NN
cord-341050-hnuogpqn	156	34	into	into	IN
cord-341050-hnuogpqn	156	35	the	the	DT
cord-341050-hnuogpqn	156	36	cytoplasm	cytoplasm	NN
cord-341050-hnuogpqn	156	37	for	for	IN
cord-341050-hnuogpqn	156	38	replication	replication	NN
cord-341050-hnuogpqn	156	39	[	[	-LRB-
cord-341050-hnuogpqn	156	40	213	213	CD
cord-341050-hnuogpqn	156	41	]	]	-RRB-
cord-341050-hnuogpqn	156	42	.	.	.
cord-341050-hnuogpqn	157	1	Inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	157	2	that	that	WDT
cord-341050-hnuogpqn	157	3	disrupt	disrupt	VBP
cord-341050-hnuogpqn	157	4	the	the	DT
cord-341050-hnuogpqn	157	5	interaction	interaction	NN
cord-341050-hnuogpqn	157	6	of	of	IN
cord-341050-hnuogpqn	157	7	E	e	NN
cord-341050-hnuogpqn	157	8	protein	protein	NN
cord-341050-hnuogpqn	157	9	with	with	IN
cord-341050-hnuogpqn	157	10	cell	cell	NN
cord-341050-hnuogpqn	157	11	receptors	receptor	NNS
cord-341050-hnuogpqn	157	12	or	or	CC
cord-341050-hnuogpqn	157	13	inhibit	inhibit	VB
cord-341050-hnuogpqn	157	14	membrane	membrane	NN
cord-341050-hnuogpqn	157	15	fusion	fusion	NN
cord-341050-hnuogpqn	157	16	would	would	MD
cord-341050-hnuogpqn	157	17	be	be	VB
cord-341050-hnuogpqn	157	18	a	a	DT
cord-341050-hnuogpqn	157	19	potential	potential	JJ
cord-341050-hnuogpqn	157	20	antiviral	antiviral	JJ
cord-341050-hnuogpqn	157	21	against	against	IN
cord-341050-hnuogpqn	157	22	WNV	WNV	NNP
cord-341050-hnuogpqn	157	23	.	.	.
cord-341050-hnuogpqn	158	1	Two	two	CD
cord-341050-hnuogpqn	158	2	successful	successful	JJ
cord-341050-hnuogpqn	158	3	HIV	HIV	NNP
cord-341050-hnuogpqn	158	4	drug	drug	NN
cord-341050-hnuogpqn	158	5	Maraviroc	Maraviroc	NNP
cord-341050-hnuogpqn	158	6	(	(	-LRB-
cord-341050-hnuogpqn	158	7	CCR5	CCR5	NNP
cord-341050-hnuogpqn	158	8	antagonist	antagonist	NN
cord-341050-hnuogpqn	158	9	)	)	-RRB-
cord-341050-hnuogpqn	158	10	and	and	CC
cord-341050-hnuogpqn	158	11	Enfuvirtide	Enfuvirtide	NNP
cord-341050-hnuogpqn	158	12	(	(	-LRB-
cord-341050-hnuogpqn	158	13	a	a	DT
cord-341050-hnuogpqn	158	14	peptide	peptide	JJ
cord-341050-hnuogpqn	158	15	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	158	16	)	)	-RRB-
cord-341050-hnuogpqn	158	17	that	that	WDT
cord-341050-hnuogpqn	158	18	respectively	respectively	RB
cord-341050-hnuogpqn	158	19	block	block	VBP
cord-341050-hnuogpqn	158	20	viral	viral	JJ
cord-341050-hnuogpqn	158	21	entry	entry	NN
cord-341050-hnuogpqn	158	22	[	[	-LRB-
cord-341050-hnuogpqn	158	23	214	214	CD
cord-341050-hnuogpqn	158	24	]	]	-RRB-
cord-341050-hnuogpqn	158	25	and	and	CC
cord-341050-hnuogpqn	158	26	membrane	membrane	NN
cord-341050-hnuogpqn	158	27	fusion	fusion	NN
cord-341050-hnuogpqn	158	28	[	[	-LRB-
cord-341050-hnuogpqn	158	29	215	215	CD
cord-341050-hnuogpqn	158	30	]	]	-RRB-
cord-341050-hnuogpqn	158	31	attest	attest	RB
cord-341050-hnuogpqn	158	32	to	to	IN
cord-341050-hnuogpqn	158	33	this	this	DT
cord-341050-hnuogpqn	158	34	antiviral	antiviral	JJ
cord-341050-hnuogpqn	158	35	strategy	strategy	NN
cord-341050-hnuogpqn	158	36	.	.	.
cord-341050-hnuogpqn	159	1	The	the	DT
cord-341050-hnuogpqn	159	2	fl	fl	NNP
cord-341050-hnuogpqn	159	3	aviviral	aviviral	NN
cord-341050-hnuogpqn	159	4	E	E	NNP
cord-341050-hnuogpqn	159	5	glycoprotein	glycoprotein	NN
cord-341050-hnuogpqn	159	6	contains	contain	VBZ
cord-341050-hnuogpqn	159	7	several	several	JJ
cord-341050-hnuogpqn	159	8	functional	functional	JJ
cord-341050-hnuogpqn	159	9	sites	site	NNS
cord-341050-hnuogpqn	159	10	such	such	JJ
cord-341050-hnuogpqn	159	11	as	as	IN
cord-341050-hnuogpqn	159	12	a	a	DT
cord-341050-hnuogpqn	159	13	hydrophobic	hydrophobic	JJ
cord-341050-hnuogpqn	159	14	pocket	pocket	NN
cord-341050-hnuogpqn	159	15	,	,	,
cord-341050-hnuogpqn	159	16	the	the	DT
cord-341050-hnuogpqn	159	17	receptor	receptor	NN
cord-341050-hnuogpqn	159	18	-	-	HYPH
cord-341050-hnuogpqn	159	19	binding	bind	VBG
cord-341050-hnuogpqn	159	20	domain	domain	NN
cord-341050-hnuogpqn	159	21	and	and	CC
cord-341050-hnuogpqn	159	22	stem	stem	NN
cord-341050-hnuogpqn	159	23	domain	domain	NN
cord-341050-hnuogpqn	159	24	that	that	WDT
cord-341050-hnuogpqn	159	25	may	may	MD
cord-341050-hnuogpqn	159	26	be	be	VB
cord-341050-hnuogpqn	159	27	targeted	target	VBN
cord-341050-hnuogpqn	159	28	by	by	IN
cord-341050-hnuogpqn	159	29	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	159	30	.	.	.
cord-341050-hnuogpqn	160	1	Among	among	IN
cord-341050-hnuogpqn	160	2	these	these	DT
cord-341050-hnuogpqn	160	3	,	,	,
cord-341050-hnuogpqn	160	4	the	the	DT
cord-341050-hnuogpqn	160	5	hydrophobic	hydrophobic	JJ
cord-341050-hnuogpqn	160	6	ligand	ligand	NN
cord-341050-hnuogpqn	160	7	-	-	HYPH
cord-341050-hnuogpqn	160	8	binding	bind	VBG
cord-341050-hnuogpqn	160	9	pocket	pocket	NN
cord-341050-hnuogpqn	160	10	in	in	IN
cord-341050-hnuogpqn	160	11	a	a	DT
cord-341050-hnuogpqn	160	12	hinge	hinge	NN
cord-341050-hnuogpqn	160	13	region	region	NN
cord-341050-hnuogpqn	160	14	between	between	IN
cord-341050-hnuogpqn	160	15	domain	domain	NN
cord-341050-hnuogpqn	160	16	I	I	NNP
cord-341050-hnuogpqn	160	17	and	and	CC
cord-341050-hnuogpqn	160	18	II	II	NNP
cord-341050-hnuogpqn	160	19	of	of	IN
cord-341050-hnuogpqn	160	20	E	E	NNP
cord-341050-hnuogpqn	160	21	protein	protein	NN
cord-341050-hnuogpqn	160	22	plays	play	VBZ
cord-341050-hnuogpqn	160	23	an	an	DT
cord-341050-hnuogpqn	160	24	important	important	JJ
cord-341050-hnuogpqn	160	25	role	role	NN
cord-341050-hnuogpqn	160	26	in	in	IN
cord-341050-hnuogpqn	160	27	low	low	JJ
cord-341050-hnuogpqn	160	28	-	-	HYPH
cord-341050-hnuogpqn	160	29	pH	ph	NN
cord-341050-hnuogpqn	160	30	-	-	HYPH
cord-341050-hnuogpqn	160	31	mediated	mediate	VBN
cord-341050-hnuogpqn	160	32	membrane	membrane	NN
cord-341050-hnuogpqn	160	33	fusion	fusion	NN
cord-341050-hnuogpqn	160	34	process	process	NN
cord-341050-hnuogpqn	160	35	and	and	CC
cord-341050-hnuogpqn	160	36	is	be	VBZ
cord-341050-hnuogpqn	160	37	a	a	DT
cord-341050-hnuogpqn	160	38	unique	unique	JJ
cord-341050-hnuogpqn	160	39	target	target	NN
cord-341050-hnuogpqn	160	40	for	for	IN
cord-341050-hnuogpqn	160	41	developing	develop	VBG
cord-341050-hnuogpqn	160	42	smallmolecule	smallmolecule	JJ
cord-341050-hnuogpqn	160	43	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	160	44	against	against	IN
cord-341050-hnuogpqn	160	45	fl	fl	NNP
cord-341050-hnuogpqn	160	46	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	160	47	[	[	-LRB-
cord-341050-hnuogpqn	160	48	216	216	CD
cord-341050-hnuogpqn	160	49	,	,	,
cord-341050-hnuogpqn	160	50	217	217	CD
cord-341050-hnuogpqn	160	51	]	]	-RRB-
cord-341050-hnuogpqn	160	52	.	.	.
cord-341050-hnuogpqn	161	1	Various	various	JJ
cord-341050-hnuogpqn	161	2	screening	screening	NN
cord-341050-hnuogpqn	161	3	approaches	approach	NNS
cord-341050-hnuogpqn	161	4	were	be	VBD
cord-341050-hnuogpqn	161	5	used	use	VBN
cord-341050-hnuogpqn	161	6	to	to	TO
cord-341050-hnuogpqn	161	7	identify	identify	VB
cord-341050-hnuogpqn	161	8	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	161	9	against	against	IN
cord-341050-hnuogpqn	161	10	DENV	DENV	NNP
cord-341050-hnuogpqn	161	11	and	and	CC
cord-341050-hnuogpqn	161	12	other	other	JJ
cord-341050-hnuogpqn	161	13	fl	fl	NNP
cord-341050-hnuogpqn	161	14	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	161	15	that	that	WDT
cord-341050-hnuogpqn	161	16	bind	bind	VBP
cord-341050-hnuogpqn	161	17	into	into	IN
cord-341050-hnuogpqn	161	18	this	this	DT
cord-341050-hnuogpqn	161	19	hydrophobic	hydrophobic	JJ
cord-341050-hnuogpqn	161	20	pocket	pocket	NN
cord-341050-hnuogpqn	161	21	and	and	CC
cord-341050-hnuogpqn	161	22	interfere	interfere	VB
cord-341050-hnuogpqn	161	23	with	with	IN
cord-341050-hnuogpqn	161	24	the	the	DT
cord-341050-hnuogpqn	161	25	conformational	conformational	JJ
cord-341050-hnuogpqn	161	26	changes	change	NNS
cord-341050-hnuogpqn	161	27	of	of	IN
cord-341050-hnuogpqn	161	28	E	e	NN
cord-341050-hnuogpqn	161	29	protein	protein	NN
cord-341050-hnuogpqn	161	30	[	[	-LRB-
cord-341050-hnuogpqn	161	31	207	207	CD
cord-341050-hnuogpqn	161	32	,	,	,
cord-341050-hnuogpqn	161	33	218	218	CD
cord-341050-hnuogpqn	161	34	-221	-221	NN
cord-341050-hnuogpqn	161	35	]	]	-RRB-
cord-341050-hnuogpqn	161	36	,	,	,
cord-341050-hnuogpqn	161	37	Most	Most	JJS
cord-341050-hnuogpqn	161	38	of	of	IN
cord-341050-hnuogpqn	161	39	these	these	DT
cord-341050-hnuogpqn	161	40	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	161	41	were	be	VBD
cord-341050-hnuogpqn	161	42	designed	design	VBN
cord-341050-hnuogpqn	161	43	and	and	CC
cord-341050-hnuogpqn	161	44	tested	test	VBN
cord-341050-hnuogpqn	161	45	against	against	IN
cord-341050-hnuogpqn	161	46	DENV	DENV	NNP
cord-341050-hnuogpqn	161	47	,	,	,
cord-341050-hnuogpqn	161	48	some	some	DT
cord-341050-hnuogpqn	161	49	of	of	IN
cord-341050-hnuogpqn	161	50	which	which	WDT
cord-341050-hnuogpqn	161	51	were	be	VBD
cord-341050-hnuogpqn	161	52	reported	report	VBN
cord-341050-hnuogpqn	161	53	to	to	TO
cord-341050-hnuogpqn	161	54	exhibit	exhibit	VB
cord-341050-hnuogpqn	161	55	antiviral	antiviral	JJ
cord-341050-hnuogpqn	161	56	activities	activity	NNS
cord-341050-hnuogpqn	161	57	against	against	IN
cord-341050-hnuogpqn	161	58	WNV	WNV	NNP
cord-341050-hnuogpqn	161	59	[	[	-LRB-
cord-341050-hnuogpqn	161	60	207	207	CD
cord-341050-hnuogpqn	161	61	,	,	,
cord-341050-hnuogpqn	161	62	220	220	CD
cord-341050-hnuogpqn	161	63	]	]	-RRB-
cord-341050-hnuogpqn	161	64	.	.	.
cord-341050-hnuogpqn	162	1	However	however	RB
cord-341050-hnuogpqn	162	2	,	,	,
cord-341050-hnuogpqn	162	3	these	these	DT
cord-341050-hnuogpqn	162	4	compounds	compound	NNS
cord-341050-hnuogpqn	162	5	failed	fail	VBD
cord-341050-hnuogpqn	162	6	in	in	IN
cord-341050-hnuogpqn	162	7	the	the	DT
cord-341050-hnuogpqn	162	8	further	further	JJ
cord-341050-hnuogpqn	162	9	drug	drug	NN
cord-341050-hnuogpqn	162	10	development	development	NN
cord-341050-hnuogpqn	162	11	due	due	IN
cord-341050-hnuogpqn	162	12	to	to	IN
cord-341050-hnuogpqn	162	13	their	-PRON-	PRP$
cord-341050-hnuogpqn	162	14	undesirable	undesirable	JJ
cord-341050-hnuogpqn	162	15	properties	property	NNS
cord-341050-hnuogpqn	162	16	,	,	,
cord-341050-hnuogpqn	162	17	such	such	JJ
cord-341050-hnuogpqn	162	18	as	as	IN
cord-341050-hnuogpqn	162	19	low	low	JJ
cord-341050-hnuogpqn	162	20	solubility	solubility	NN
cord-341050-hnuogpqn	162	21	and	and	CC
cord-341050-hnuogpqn	162	22	cytotoxicity	cytotoxicity	NN
cord-341050-hnuogpqn	162	23	.	.	.
cord-341050-hnuogpqn	163	1	The	the	DT
cord-341050-hnuogpqn	163	2	domain	domain	NN
cord-341050-hnuogpqn	163	3	III	III	NNP
cord-341050-hnuogpqn	163	4	of	of	IN
cord-341050-hnuogpqn	163	5	E	e	NN
cord-341050-hnuogpqn	163	6	glycoprotein	glycoprotein	NN
cord-341050-hnuogpqn	163	7	that	that	WDT
cord-341050-hnuogpqn	163	8	mediates	mediate	VBZ
cord-341050-hnuogpqn	163	9	receptor	receptor	NN
cord-341050-hnuogpqn	163	10	-	-	HYPH
cord-341050-hnuogpqn	163	11	binding	binding	NN
cord-341050-hnuogpqn	163	12	can	can	MD
cord-341050-hnuogpqn	163	13	be	be	VB
cord-341050-hnuogpqn	163	14	potentially	potentially	RB
cord-341050-hnuogpqn	163	15	targeted	target	VBN
cord-341050-hnuogpqn	163	16	by	by	IN
cord-341050-hnuogpqn	163	17	developing	develop	VBG
cord-341050-hnuogpqn	163	18	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	163	19	that	that	WDT
cord-341050-hnuogpqn	163	20	can	can	MD
cord-341050-hnuogpqn	163	21	disrupt	disrupt	VB
cord-341050-hnuogpqn	163	22	the	the	DT
cord-341050-hnuogpqn	163	23	viral	viral	JJ
cord-341050-hnuogpqn	163	24	attachment	attachment	NN
cord-341050-hnuogpqn	163	25	to	to	TO
cord-341050-hnuogpqn	163	26	host	host	VB
cord-341050-hnuogpqn	163	27	cell	cell	NN
cord-341050-hnuogpqn	163	28	receptors	receptor	NNS
cord-341050-hnuogpqn	163	29	.	.	.
cord-341050-hnuogpqn	164	1	Neutralizing	neutralize	VBG
cord-341050-hnuogpqn	164	2	antibodies	antibody	NNS
cord-341050-hnuogpqn	164	3	against	against	IN
cord-341050-hnuogpqn	164	4	E	e	NN
cord-341050-hnuogpqn	164	5	protein	protein	NN
cord-341050-hnuogpqn	164	6	have	have	VBP
cord-341050-hnuogpqn	164	7	proven	prove	VBN
cord-341050-hnuogpqn	164	8	the	the	DT
cord-341050-hnuogpqn	164	9	potential	potential	NN
cord-341050-hnuogpqn	164	10	of	of	IN
cord-341050-hnuogpqn	164	11	this	this	DT
cord-341050-hnuogpqn	164	12	strategy	strategy	NN
cord-341050-hnuogpqn	164	13	.	.	.
cord-341050-hnuogpqn	165	1	Several	several	JJ
cord-341050-hnuogpqn	165	2	compounds	compound	NNS
cord-341050-hnuogpqn	165	3	have	have	VBP
cord-341050-hnuogpqn	165	4	also	also	RB
cord-341050-hnuogpqn	165	5	been	be	VBN
cord-341050-hnuogpqn	165	6	shown	show	VBN
cord-341050-hnuogpqn	165	7	to	to	TO
cord-341050-hnuogpqn	165	8	interfere	interfere	VB
cord-341050-hnuogpqn	165	9	with	with	IN
cord-341050-hnuogpqn	165	10	the	the	DT
cord-341050-hnuogpqn	165	11	binding	binding	NN
cord-341050-hnuogpqn	165	12	of	of	IN
cord-341050-hnuogpqn	165	13	fl	fl	NNP
cord-341050-hnuogpqn	165	14	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	165	15	to	to	TO
cord-341050-hnuogpqn	165	16	host	host	VB
cord-341050-hnuogpqn	165	17	cell	cell	NN
cord-341050-hnuogpqn	165	18	receptors	receptor	NNS
cord-341050-hnuogpqn	165	19	[	[	-LRB-
cord-341050-hnuogpqn	165	20	222	222	CD
cord-341050-hnuogpqn	165	21	-226	-226	NN
cord-341050-hnuogpqn	165	22	]	]	-RRB-
cord-341050-hnuogpqn	165	23	.	.	.
cord-341050-hnuogpqn	166	1	However	however	RB
cord-341050-hnuogpqn	166	2	,	,	,
cord-341050-hnuogpqn	166	3	lack	lack	NN
cord-341050-hnuogpqn	166	4	of	of	IN
cord-341050-hnuogpqn	166	5	understanding	understanding	NN
cord-341050-hnuogpqn	166	6	of	of	IN
cord-341050-hnuogpqn	166	7	cell	cell	NN
cord-341050-hnuogpqn	166	8	receptor	receptor	NN
cord-341050-hnuogpqn	166	9	for	for	IN
cord-341050-hnuogpqn	166	10	WNV	WNV	NNP
cord-341050-hnuogpqn	166	11	has	have	VBZ
cord-341050-hnuogpqn	166	12	hampered	hamper	VBN
cord-341050-hnuogpqn	166	13	the	the	DT
cord-341050-hnuogpqn	166	14	success	success	NN
cord-341050-hnuogpqn	166	15	of	of	IN
cord-341050-hnuogpqn	166	16	this	this	DT
cord-341050-hnuogpqn	166	17	approach	approach	NN
cord-341050-hnuogpqn	166	18	.	.	.
cord-341050-hnuogpqn	167	1	Identifi	Identifi	NNP
cord-341050-hnuogpqn	167	2	cation	cation	NN
cord-341050-hnuogpqn	167	3	of	of	IN
cord-341050-hnuogpqn	167	4	cellular	cellular	JJ
cord-341050-hnuogpqn	167	5	receptors	receptor	NNS
cord-341050-hnuogpqn	167	6	for	for	IN
cord-341050-hnuogpqn	167	7	WNV	WNV	NNP
cord-341050-hnuogpqn	167	8	and	and	CC
cord-341050-hnuogpqn	167	9	understanding	understanding	NN
cord-341050-hnuogpqn	167	10	of	of	IN
cord-341050-hnuogpqn	167	11	virus	virus	NN
cord-341050-hnuogpqn	167	12	-	-	HYPH
cord-341050-hnuogpqn	167	13	receptor	receptor	NN
cord-341050-hnuogpqn	167	14	interaction	interaction	NN
cord-341050-hnuogpqn	167	15	may	may	MD
cord-341050-hnuogpqn	167	16	provide	provide	VB
cord-341050-hnuogpqn	167	17	new	new	JJ
cord-341050-hnuogpqn	167	18	opportunities	opportunity	NNS
cord-341050-hnuogpqn	167	19	to	to	TO
cord-341050-hnuogpqn	167	20	identify	identify	VB
cord-341050-hnuogpqn	167	21	small	small	JJ
cord-341050-hnuogpqn	167	22	molecule	molecule	NN
cord-341050-hnuogpqn	167	23	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	167	24	that	that	WDT
cord-341050-hnuogpqn	167	25	interrupt	interrupt	VBP
cord-341050-hnuogpqn	167	26	the	the	DT
cord-341050-hnuogpqn	167	27	binding	binding	NN
cord-341050-hnuogpqn	167	28	of	of	IN
cord-341050-hnuogpqn	167	29	WNV	WNV	NNP
cord-341050-hnuogpqn	167	30	to	to	TO
cord-341050-hnuogpqn	167	31	host	host	VB
cord-341050-hnuogpqn	167	32	cell	cell	NN
cord-341050-hnuogpqn	167	33	receptors	receptor	NNS
cord-341050-hnuogpqn	167	34	.	.	.
cord-341050-hnuogpqn	168	1	Viral	viral	JJ
cord-341050-hnuogpqn	168	2	proteases	protease	NNS
cord-341050-hnuogpqn	168	3	are	be	VBP
cord-341050-hnuogpqn	168	4	essential	essential	JJ
cord-341050-hnuogpqn	168	5	for	for	IN
cord-341050-hnuogpqn	168	6	WNV	WNV	NNP
cord-341050-hnuogpqn	168	7	life	life	NN
cord-341050-hnuogpqn	168	8	cycle	cycle	NN
cord-341050-hnuogpqn	168	9	for	for	IN
cord-341050-hnuogpqn	168	10	they	-PRON-	PRP
cord-341050-hnuogpqn	168	11	cleave	cleave	VBP
cord-341050-hnuogpqn	168	12	the	the	DT
cord-341050-hnuogpqn	168	13	viral	viral	JJ
cord-341050-hnuogpqn	168	14	polyprotein	polyprotein	JJ
cord-341050-hnuogpqn	168	15	precursors	precursor	NNS
cord-341050-hnuogpqn	168	16	into	into	IN
cord-341050-hnuogpqn	168	17	functional	functional	JJ
cord-341050-hnuogpqn	168	18	proteins	protein	NNS
cord-341050-hnuogpqn	168	19	.	.	.
cord-341050-hnuogpqn	169	1	Successful	successful	JJ
cord-341050-hnuogpqn	169	2	development	development	NN
cord-341050-hnuogpqn	169	3	and	and	CC
cord-341050-hnuogpqn	169	4	licensing	licensing	NN
cord-341050-hnuogpqn	169	5	of	of	IN
cord-341050-hnuogpqn	169	6	protease	protease	NN
cord-341050-hnuogpqn	169	7	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	169	8	against	against	IN
cord-341050-hnuogpqn	169	9	HIV-1	HIV-1	NNP
cord-341050-hnuogpqn	169	10	[	[	-LRB-
cord-341050-hnuogpqn	169	11	227	227	CD
cord-341050-hnuogpqn	169	12	,	,	,
cord-341050-hnuogpqn	169	13	228	228	CD
cord-341050-hnuogpqn	169	14	]	]	-RRB-
cord-341050-hnuogpqn	169	15	and	and	CC
cord-341050-hnuogpqn	170	1	HCV	HCV	NNP
cord-341050-hnuogpqn	170	2	[	[	-LRB-
cord-341050-hnuogpqn	170	3	229	229	CD
cord-341050-hnuogpqn	170	4	,	,	,
cord-341050-hnuogpqn	170	5	230	230	CD
cord-341050-hnuogpqn	170	6	]	]	-RRB-
cord-341050-hnuogpqn	170	7	provides	provide	VBZ
cord-341050-hnuogpqn	170	8	the	the	DT
cord-341050-hnuogpqn	170	9	proof	proof	NN
cord-341050-hnuogpqn	170	10	of	of	IN
cord-341050-hnuogpqn	170	11	concept	concept	NN
cord-341050-hnuogpqn	170	12	and	and	CC
cord-341050-hnuogpqn	170	13	feasibility	feasibility	NN
cord-341050-hnuogpqn	170	14	for	for	IN
cord-341050-hnuogpqn	170	15	similar	similar	JJ
cord-341050-hnuogpqn	170	16	targeting	targeting	NN
cord-341050-hnuogpqn	170	17	of	of	IN
cord-341050-hnuogpqn	170	18	proteases	protease	NNS
cord-341050-hnuogpqn	170	19	of	of	IN
cord-341050-hnuogpqn	170	20	other	other	JJ
cord-341050-hnuogpqn	170	21	viruses	virus	NNS
cord-341050-hnuogpqn	170	22	.	.	.
cord-341050-hnuogpqn	171	1	The	the	DT
cord-341050-hnuogpqn	171	2	N	n	CD
cord-341050-hnuogpqn	171	3	-	-	HYPH
cord-341050-hnuogpqn	171	4	terminal	terminal	NN
cord-341050-hnuogpqn	171	5	domain	domain	NN
cord-341050-hnuogpqn	171	6	of	of	IN
cord-341050-hnuogpqn	171	7	fl	fl	NNP
cord-341050-hnuogpqn	171	8	aviviral	aviviral	JJ
cord-341050-hnuogpqn	171	9	NS3	ns3	RB
cord-341050-hnuogpqn	171	10	(	(	-LRB-
cord-341050-hnuogpqn	171	11	amino	amino	NN
cord-341050-hnuogpqn	171	12	acids	acid	NNS
cord-341050-hnuogpqn	171	13	1	1	CD
cord-341050-hnuogpqn	171	14	-	-	SYM
cord-341050-hnuogpqn	171	15	169	169	CD
cord-341050-hnuogpqn	171	16	)	)	-RRB-
cord-341050-hnuogpqn	172	1	has	have	VBZ
cord-341050-hnuogpqn	172	2	serine	serine	JJ
cord-341050-hnuogpqn	172	3	protease	protease	NN
cord-341050-hnuogpqn	172	4	activity	activity	NN
cord-341050-hnuogpqn	172	5	whereas	whereas	IN
cord-341050-hnuogpqn	172	6	a	a	DT
cord-341050-hnuogpqn	172	7	hydrophobic	hydrophobic	JJ
cord-341050-hnuogpqn	172	8	region	region	NN
cord-341050-hnuogpqn	172	9	of	of	IN
cord-341050-hnuogpqn	172	10	NS2B	NS2B	NNP
cord-341050-hnuogpqn	172	11	protein	protein	NN
cord-341050-hnuogpqn	172	12	serves	serve	VBZ
cord-341050-hnuogpqn	172	13	as	as	IN
cord-341050-hnuogpqn	172	14	cofactor	cofactor	NN
cord-341050-hnuogpqn	172	15	to	to	TO
cord-341050-hnuogpqn	172	16	activate	activate	VB
cord-341050-hnuogpqn	172	17	the	the	DT
cord-341050-hnuogpqn	172	18	enzymatic	enzymatic	JJ
cord-341050-hnuogpqn	172	19	activity	activity	NN
cord-341050-hnuogpqn	172	20	of	of	IN
cord-341050-hnuogpqn	172	21	NS3	ns3	RB
cord-341050-hnuogpqn	172	22	[	[	-LRB-
cord-341050-hnuogpqn	172	23	53	53	CD
cord-341050-hnuogpqn	172	24	,	,	,
cord-341050-hnuogpqn	172	25	231	231	CD
cord-341050-hnuogpqn	172	26	,	,	,
cord-341050-hnuogpqn	172	27	232	232	CD
cord-341050-hnuogpqn	172	28	]	]	-RRB-
cord-341050-hnuogpqn	172	29	.	.	.
cord-341050-hnuogpqn	173	1	The	the	DT
cord-341050-hnuogpqn	173	2	NS3	ns3	JJ
cord-341050-hnuogpqn	173	3	protease	protease	NN
cord-341050-hnuogpqn	173	4	of	of	IN
cord-341050-hnuogpqn	173	5	WNV	WNV	NNP
cord-341050-hnuogpqn	173	6	processes	process	VBZ
cord-341050-hnuogpqn	173	7	the	the	DT
cord-341050-hnuogpqn	173	8	viral	viral	JJ
cord-341050-hnuogpqn	173	9	polyprotein	polyprotein	JJ
cord-341050-hnuogpqn	173	10	precursor	precursor	NN
cord-341050-hnuogpqn	173	11	into	into	IN
cord-341050-hnuogpqn	173	12	structural	structural	JJ
cord-341050-hnuogpqn	173	13	and	and	CC
cord-341050-hnuogpqn	173	14	non	non	JJ
cord-341050-hnuogpqn	173	15	-	-	JJ
cord-341050-hnuogpqn	173	16	structural	structural	JJ
cord-341050-hnuogpqn	173	17	proteins	protein	NNS
cord-341050-hnuogpqn	173	18	and	and	CC
cord-341050-hnuogpqn	173	19	disruption	disruption	NN
cord-341050-hnuogpqn	173	20	of	of	IN
cord-341050-hnuogpqn	173	21	this	this	DT
cord-341050-hnuogpqn	173	22	activity	activity	NN
cord-341050-hnuogpqn	173	23	is	be	VBZ
cord-341050-hnuogpqn	173	24	lethal	lethal	JJ
cord-341050-hnuogpqn	173	25	for	for	IN
cord-341050-hnuogpqn	173	26	WNV	WNV	NNP
cord-341050-hnuogpqn	173	27	[	[	-LRB-
cord-341050-hnuogpqn	173	28	54	54	CD
cord-341050-hnuogpqn	173	29	,	,	,
cord-341050-hnuogpqn	173	30	57	57	CD
cord-341050-hnuogpqn	173	31	]	]	-RRB-
cord-341050-hnuogpqn	173	32	.	.	.
cord-341050-hnuogpqn	174	1	In	in	IN
cord-341050-hnuogpqn	174	2	addition	addition	NN
cord-341050-hnuogpqn	174	3	,	,	,
cord-341050-hnuogpqn	174	4	WNV	WNV	NNP
cord-341050-hnuogpqn	174	5	NS2B	NS2B	NNP
cord-341050-hnuogpqn	174	6	/	/	SYM
cord-341050-hnuogpqn	174	7	NS3	ns3	RB
cord-341050-hnuogpqn	174	8	protease	protease	NN
cord-341050-hnuogpqn	174	9	can	can	MD
cord-341050-hnuogpqn	174	10	also	also	RB
cord-341050-hnuogpqn	174	11	cleave	cleave	VB
cord-341050-hnuogpqn	174	12	host	host	NN
cord-341050-hnuogpqn	174	13	proteins	protein	NNS
cord-341050-hnuogpqn	174	14	and	and	CC
cord-341050-hnuogpqn	174	15	may	may	MD
cord-341050-hnuogpqn	174	16	contribute	contribute	VB
cord-341050-hnuogpqn	174	17	to	to	IN
cord-341050-hnuogpqn	174	18	neuropathogenesis	neuropathogenesis	NNP
cord-341050-hnuogpqn	174	19	[	[	-LRB-
cord-341050-hnuogpqn	174	20	63	63	CD
cord-341050-hnuogpqn	174	21	]	]	-RRB-
cord-341050-hnuogpqn	174	22	.	.	.
cord-341050-hnuogpqn	175	1	Recent	recent	JJ
cord-341050-hnuogpqn	175	2	progress	progress	NN
cord-341050-hnuogpqn	175	3	in	in	IN
cord-341050-hnuogpqn	175	4	the	the	DT
cord-341050-hnuogpqn	175	5	expression	expression	NN
cord-341050-hnuogpqn	175	6	of	of	IN
cord-341050-hnuogpqn	175	7	stable	stable	JJ
cord-341050-hnuogpqn	175	8	NS2B	NS2B	NNP
cord-341050-hnuogpqn	175	9	/	/	SYM
cord-341050-hnuogpqn	175	10	NS3	ns3	RB
cord-341050-hnuogpqn	175	11	and	and	CC
cord-341050-hnuogpqn	175	12	identifi	identifi	NNP
cord-341050-hnuogpqn	175	13	cation	cation	NNP
cord-341050-hnuogpqn	175	14	of	of	IN
cord-341050-hnuogpqn	175	15	the	the	DT
cord-341050-hnuogpqn	175	16	highaffi	highaffi	NNP
cord-341050-hnuogpqn	175	17	nity	nity	NNP
cord-341050-hnuogpqn	175	18	substrate	substrate	NN
cord-341050-hnuogpqn	175	19	for	for	IN
cord-341050-hnuogpqn	175	20	this	this	DT
cord-341050-hnuogpqn	175	21	viral	viral	JJ
cord-341050-hnuogpqn	175	22	enzyme	enzyme	NN
cord-341050-hnuogpqn	175	23	has	have	VBZ
cord-341050-hnuogpqn	175	24	promoted	promote	VBN
cord-341050-hnuogpqn	175	25	large	large	JJ
cord-341050-hnuogpqn	175	26	-	-	HYPH
cord-341050-hnuogpqn	175	27	scale	scale	NN
cord-341050-hnuogpqn	175	28	Dhiraj	Dhiraj	NNP
cord-341050-hnuogpqn	175	29	Acharya	Acharya	NNP
cord-341050-hnuogpqn	175	30	and	and	CC
cord-341050-hnuogpqn	175	31	Fengwei	Fengwei	NNP
cord-341050-hnuogpqn	175	32	Bai	Bai	NNP
cord-341050-hnuogpqn	175	33	screening	screening	NN
cord-341050-hnuogpqn	175	34	of	of	IN
cord-341050-hnuogpqn	175	35	protease	protease	NN
cord-341050-hnuogpqn	175	36	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	175	37	for	for	IN
cord-341050-hnuogpqn	175	38	WNV	WNV	NNP
cord-341050-hnuogpqn	175	39	and	and	CC
cord-341050-hnuogpqn	175	40	other	other	JJ
cord-341050-hnuogpqn	175	41	fl	fl	NNP
cord-341050-hnuogpqn	175	42	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	175	43	.	.	.
cord-341050-hnuogpqn	176	1	A	a	DT
cord-341050-hnuogpqn	176	2	wide	wide	JJ
cord-341050-hnuogpqn	176	3	range	range	NN
cord-341050-hnuogpqn	176	4	of	of	IN
cord-341050-hnuogpqn	176	5	assays	assay	NNS
cord-341050-hnuogpqn	176	6	,	,	,
cord-341050-hnuogpqn	176	7	such	such	JJ
cord-341050-hnuogpqn	176	8	as	as	IN
cord-341050-hnuogpqn	176	9	conventional	conventional	JJ
cord-341050-hnuogpqn	176	10	enzyme	enzyme	NN
cord-341050-hnuogpqn	176	11	-	-	HYPH
cord-341050-hnuogpqn	176	12	substrate	substrate	NN
cord-341050-hnuogpqn	176	13	based	base	VBN
cord-341050-hnuogpqn	176	14	detection	detection	NN
cord-341050-hnuogpqn	176	15	,	,	,
cord-341050-hnuogpqn	176	16	HPLC	HPLC	NNP
cord-341050-hnuogpqn	176	17	,	,	,
cord-341050-hnuogpqn	176	18	ELISA	ELISA	NNP
cord-341050-hnuogpqn	176	19	,	,	,
cord-341050-hnuogpqn	176	20	and	and	CC
cord-341050-hnuogpqn	176	21	high	high	JJ
cord-341050-hnuogpqn	176	22	-	-	HYPH
cord-341050-hnuogpqn	176	23	throughput	throughput	NN
cord-341050-hnuogpqn	176	24	fl	fl	NNP
cord-341050-hnuogpqn	176	25	uorescencebased	uorescencebased	JJ
cord-341050-hnuogpqn	176	26	detection	detection	NN
cord-341050-hnuogpqn	176	27	methods	method	NNS
cord-341050-hnuogpqn	176	28	have	have	VBP
cord-341050-hnuogpqn	176	29	been	be	VBN
cord-341050-hnuogpqn	176	30	developed	develop	VBN
cord-341050-hnuogpqn	176	31	for	for	IN
cord-341050-hnuogpqn	176	32	screening	screening	NN
cord-341050-hnuogpqn	176	33	of	of	IN
cord-341050-hnuogpqn	176	34	viral	viral	JJ
cord-341050-hnuogpqn	176	35	protease	protease	NN
cord-341050-hnuogpqn	176	36	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	176	37	[	[	-LRB-
cord-341050-hnuogpqn	176	38	233	233	CD
cord-341050-hnuogpqn	176	39	-236	-236	NN
cord-341050-hnuogpqn	176	40	]	]	-RRB-
cord-341050-hnuogpqn	176	41	.	.	.
cord-341050-hnuogpqn	177	1	Thus	thus	RB
cord-341050-hnuogpqn	177	2	,	,	,
cord-341050-hnuogpqn	177	3	NS3	ns3	RB
cord-341050-hnuogpqn	177	4	protease	protease	NN
cord-341050-hnuogpqn	177	5	is	be	VBZ
cord-341050-hnuogpqn	177	6	an	an	DT
cord-341050-hnuogpqn	177	7	attractive	attractive	JJ
cord-341050-hnuogpqn	177	8	target	target	NN
cord-341050-hnuogpqn	177	9	for	for	IN
cord-341050-hnuogpqn	177	10	the	the	DT
cord-341050-hnuogpqn	177	11	development	development	NN
cord-341050-hnuogpqn	177	12	of	of	IN
cord-341050-hnuogpqn	177	13	antiviral	antiviral	JJ
cord-341050-hnuogpqn	177	14	against	against	IN
cord-341050-hnuogpqn	177	15	WNV	WNV	NNP
cord-341050-hnuogpqn	177	16	and	and	CC
cord-341050-hnuogpqn	177	17	other	other	JJ
cord-341050-hnuogpqn	177	18	fl	fl	NNP
cord-341050-hnuogpqn	177	19	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	177	20	(	(	-LRB-
cord-341050-hnuogpqn	177	21	reviewed	review	VBN
cord-341050-hnuogpqn	177	22	by	by	IN
cord-341050-hnuogpqn	177	23	[	[	-LRB-
cord-341050-hnuogpqn	177	24	237	237	CD
cord-341050-hnuogpqn	177	25	]	]	-RRB-
cord-341050-hnuogpqn	177	26	)	)	-RRB-
cord-341050-hnuogpqn	177	27	.	.	.
cord-341050-hnuogpqn	178	1	Except	except	IN
cord-341050-hnuogpqn	178	2	for	for	IN
cord-341050-hnuogpqn	178	3	aprotinin	aprotinin	NNS
cord-341050-hnuogpqn	178	4	,	,	,
cord-341050-hnuogpqn	178	5	a	a	DT
cord-341050-hnuogpqn	178	6	pancreatic	pancreatic	JJ
cord-341050-hnuogpqn	178	7	trypsin	trypsin	NN
cord-341050-hnuogpqn	178	8	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	178	9	,	,	,
cord-341050-hnuogpqn	178	10	most	most	JJS
cord-341050-hnuogpqn	178	11	of	of	IN
cord-341050-hnuogpqn	178	12	the	the	DT
cord-341050-hnuogpqn	178	13	classical	classical	JJ
cord-341050-hnuogpqn	178	14	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	178	15	of	of	IN
cord-341050-hnuogpqn	178	16	serine	serine	NN
cord-341050-hnuogpqn	178	17	protease	protease	NN
cord-341050-hnuogpqn	178	18	do	do	VBP
cord-341050-hnuogpqn	178	19	not	not	RB
cord-341050-hnuogpqn	178	20	inhibit	inhibit	VB
cord-341050-hnuogpqn	178	21	fl	fl	NNP
cord-341050-hnuogpqn	178	22	aviviral	aviviral	JJ
cord-341050-hnuogpqn	179	1	NS2B/	NS2B/	NNP
cord-341050-hnuogpqn	179	2	NS3	ns3	RB
cord-341050-hnuogpqn	179	3	protease	protease	NN
cord-341050-hnuogpqn	179	4	activity	activity	NN
cord-341050-hnuogpqn	179	5	[	[	-LRB-
cord-341050-hnuogpqn	179	6	238	238	CD
cord-341050-hnuogpqn	179	7	,	,	,
cord-341050-hnuogpqn	179	8	239	239	CD
cord-341050-hnuogpqn	179	9	]	]	-RRB-
cord-341050-hnuogpqn	179	10	.	.	.
cord-341050-hnuogpqn	180	1	Although	although	IN
cord-341050-hnuogpqn	180	2	aprotinin	aprotinin	NNP
cord-341050-hnuogpqn	180	3	is	be	VBZ
cord-341050-hnuogpqn	180	4	a	a	DT
cord-341050-hnuogpqn	180	5	potent	potent	JJ
cord-341050-hnuogpqn	180	6	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	180	7	of	of	IN
cord-341050-hnuogpqn	180	8	fl	fl	NNP
cord-341050-hnuogpqn	180	9	aviviral	aviviral	JJ
cord-341050-hnuogpqn	180	10	protease	protease	NN
cord-341050-hnuogpqn	180	11	,	,	,
cord-341050-hnuogpqn	180	12	this	this	DT
cord-341050-hnuogpqn	180	13	compound	compound	NN
cord-341050-hnuogpqn	180	14	was	be	VBD
cord-341050-hnuogpqn	180	15	withdrawn	withdraw	VBN
cord-341050-hnuogpqn	180	16	from	from	IN
cord-341050-hnuogpqn	180	17	the	the	DT
cord-341050-hnuogpqn	180	18	market	market	NN
cord-341050-hnuogpqn	180	19	in	in	IN
cord-341050-hnuogpqn	180	20	2008	2008	CD
cord-341050-hnuogpqn	180	21	due	due	IN
cord-341050-hnuogpqn	180	22	to	to	IN
cord-341050-hnuogpqn	180	23	safety	safety	NN
cord-341050-hnuogpqn	180	24	issues	issue	NNS
cord-341050-hnuogpqn	180	25	[	[	-LRB-
cord-341050-hnuogpqn	180	26	240	240	CD
cord-341050-hnuogpqn	180	27	]	]	-RRB-
cord-341050-hnuogpqn	180	28	.	.	.
cord-341050-hnuogpqn	181	1	To	to	TO
cord-341050-hnuogpqn	181	2	screen	screen	VB
cord-341050-hnuogpqn	181	3	and	and	CC
cord-341050-hnuogpqn	181	4	identify	identify	VB
cord-341050-hnuogpqn	181	5	small	small	JJ
cord-341050-hnuogpqn	181	6	molecule	molecule	NN
cord-341050-hnuogpqn	181	7	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	181	8	of	of	IN
cord-341050-hnuogpqn	181	9	fl	fl	NNP
cord-341050-hnuogpqn	181	10	avivirus	avivirus	NNP
cord-341050-hnuogpqn	181	11	protease	protease	NN
cord-341050-hnuogpqn	181	12	,	,	,
cord-341050-hnuogpqn	181	13	both	both	DT
cord-341050-hnuogpqn	181	14	high	high	JJ
cord-341050-hnuogpqn	181	15	throughput	throughput	NN
cord-341050-hnuogpqn	181	16	screening	screening	NN
cord-341050-hnuogpqn	181	17	and	and	CC
cord-341050-hnuogpqn	181	18	structure	structure	NN
cord-341050-hnuogpqn	181	19	-	-	HYPH
cord-341050-hnuogpqn	181	20	based	base	VBN
cord-341050-hnuogpqn	181	21	drug	drug	NN
cord-341050-hnuogpqn	181	22	designing	designing	NN
cord-341050-hnuogpqn	181	23	have	have	VBP
cord-341050-hnuogpqn	181	24	been	be	VBN
cord-341050-hnuogpqn	181	25	used	use	VBN
cord-341050-hnuogpqn	181	26	.	.	.
cord-341050-hnuogpqn	182	1	These	these	DT
cord-341050-hnuogpqn	182	2	strategies	strategy	NNS
cord-341050-hnuogpqn	182	3	are	be	VBP
cord-341050-hnuogpqn	182	4	based	base	VBN
cord-341050-hnuogpqn	182	5	on	on	IN
cord-341050-hnuogpqn	182	6	the	the	DT
cord-341050-hnuogpqn	182	7	identifi	identifi	NNP
cord-341050-hnuogpqn	182	8	cation	cation	NNP
cord-341050-hnuogpqn	182	9	of	of	IN
cord-341050-hnuogpqn	182	10	allosteric	allosteric	JJ
cord-341050-hnuogpqn	182	11	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	182	12	that	that	WDT
cord-341050-hnuogpqn	182	13	target	target	VBP
cord-341050-hnuogpqn	182	14	the	the	DT
cord-341050-hnuogpqn	182	15	interface	interface	NN
cord-341050-hnuogpqn	182	16	of	of	IN
cord-341050-hnuogpqn	182	17	NS2B	NS2B	NNP
cord-341050-hnuogpqn	182	18	-	-	:
cord-341050-hnuogpqn	182	19	NS3	ns3	RB
cord-341050-hnuogpqn	182	20	protease	protease	NN
cord-341050-hnuogpqn	182	21	,	,	,
cord-341050-hnuogpqn	182	22	or	or	CC
cord-341050-hnuogpqn	182	23	the	the	DT
cord-341050-hnuogpqn	182	24	active	active	JJ
cord-341050-hnuogpqn	182	25	site	site	NN
cord-341050-hnuogpqn	182	26	of	of	IN
cord-341050-hnuogpqn	182	27	NS3	ns3	DT
cord-341050-hnuogpqn	182	28	protease	protease	NN
cord-341050-hnuogpqn	182	29	.	.	.
cord-341050-hnuogpqn	183	1	The	the	DT
cord-341050-hnuogpqn	183	2	former	former	JJ
cord-341050-hnuogpqn	183	3	strategy	strategy	NN
cord-341050-hnuogpqn	183	4	may	may	MD
cord-341050-hnuogpqn	183	5	overcome	overcome	VB
cord-341050-hnuogpqn	183	6	nonspecifi	nonspecifi	JJ
cord-341050-hnuogpqn	183	7	city	city	NN
cord-341050-hnuogpqn	183	8	of	of	IN
cord-341050-hnuogpqn	183	9	the	the	DT
cord-341050-hnuogpqn	183	10	latter	latter	JJ
cord-341050-hnuogpqn	183	11	due	due	IN
cord-341050-hnuogpqn	183	12	to	to	IN
cord-341050-hnuogpqn	183	13	the	the	DT
cord-341050-hnuogpqn	183	14	largely	largely	RB
cord-341050-hnuogpqn	183	15	conserved	conserved	JJ
cord-341050-hnuogpqn	183	16	active	active	JJ
cord-341050-hnuogpqn	183	17	sites	site	NNS
cord-341050-hnuogpqn	183	18	of	of	IN
cord-341050-hnuogpqn	183	19	the	the	DT
cord-341050-hnuogpqn	183	20	human	human	JJ
cord-341050-hnuogpqn	183	21	and	and	CC
cord-341050-hnuogpqn	183	22	viral	viral	JJ
cord-341050-hnuogpqn	183	23	serine	serine	NN
cord-341050-hnuogpqn	183	24	proteinases	proteinase	NNS
cord-341050-hnuogpqn	183	25	.	.	.
cord-341050-hnuogpqn	184	1	A	a	DT
cord-341050-hnuogpqn	184	2	number	number	NN
cord-341050-hnuogpqn	184	3	of	of	IN
cord-341050-hnuogpqn	184	4	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	184	5	for	for	IN
cord-341050-hnuogpqn	184	6	WNV	WNV	NNP
cord-341050-hnuogpqn	185	1	NS2B	NS2B	NNP
cord-341050-hnuogpqn	185	2	/	/	,
cord-341050-hnuogpqn	185	3	NS3	ns3	RB
cord-341050-hnuogpqn	185	4	protease	protease	NN
cord-341050-hnuogpqn	185	5	have	have	VBP
cord-341050-hnuogpqn	185	6	been	be	VBN
cord-341050-hnuogpqn	185	7	identifi	identifi	VBN
cord-341050-hnuogpqn	185	8	ed	ed	NN
cord-341050-hnuogpqn	185	9	by	by	IN
cord-341050-hnuogpqn	185	10	in	in	IN
cord-341050-hnuogpqn	185	11	silico	silico	NN
cord-341050-hnuogpqn	185	12	docking	docking	NN
cord-341050-hnuogpqn	185	13	or	or	CC
cord-341050-hnuogpqn	185	14	high	high	JJ
cord-341050-hnuogpqn	185	15	-	-	HYPH
cord-341050-hnuogpqn	185	16	throughput	throughput	NN
cord-341050-hnuogpqn	185	17	screen	screen	NN
cord-341050-hnuogpqn	185	18	using	use	VBG
cord-341050-hnuogpqn	186	1	in	in	FW
cord-341050-hnuogpqn	186	2	vitro	vitro	FW
cord-341050-hnuogpqn	186	3	enzyme	enzyme	NN
cord-341050-hnuogpqn	186	4	activitybased	activitybase	VBN
cord-341050-hnuogpqn	186	5	assays	assay	NNS
cord-341050-hnuogpqn	186	6	[	[	-LRB-
cord-341050-hnuogpqn	186	7	34	34	CD
cord-341050-hnuogpqn	186	8	,	,	,
cord-341050-hnuogpqn	186	9	59	59	CD
cord-341050-hnuogpqn	186	10	,	,	,
cord-341050-hnuogpqn	186	11	206	206	CD
cord-341050-hnuogpqn	186	12	,	,	,
cord-341050-hnuogpqn	186	13	241	241	CD
cord-341050-hnuogpqn	186	14	-249	-249	NN
cord-341050-hnuogpqn	186	15	]	]	-RRB-
cord-341050-hnuogpqn	186	16	.	.	.
cord-341050-hnuogpqn	187	1	However	however	RB
cord-341050-hnuogpqn	187	2	,	,	,
cord-341050-hnuogpqn	187	3	most	most	JJS
cord-341050-hnuogpqn	187	4	of	of	IN
cord-341050-hnuogpqn	187	5	these	these	DT
cord-341050-hnuogpqn	187	6	compounds	compound	NNS
cord-341050-hnuogpqn	187	7	failed	fail	VBD
cord-341050-hnuogpqn	187	8	to	to	TO
cord-341050-hnuogpqn	187	9	demonstrate	demonstrate	VB
cord-341050-hnuogpqn	187	10	potent	potent	JJ
cord-341050-hnuogpqn	187	11	antiviral	antiviral	JJ
cord-341050-hnuogpqn	187	12	activity	activity	NN
cord-341050-hnuogpqn	187	13	in	in	IN
cord-341050-hnuogpqn	187	14	cell	cell	NN
cord-341050-hnuogpqn	187	15	culture	culture	NN
cord-341050-hnuogpqn	187	16	.	.	.
cord-341050-hnuogpqn	188	1	Although	although	IN
cord-341050-hnuogpqn	188	2	a	a	DT
cord-341050-hnuogpqn	188	3	few	few	JJ
cord-341050-hnuogpqn	188	4	compounds	compound	NNS
cord-341050-hnuogpqn	188	5	identifi	identifi	NN
cord-341050-hnuogpqn	188	6	ed	ed	NN
cord-341050-hnuogpqn	188	7	by	by	IN
cord-341050-hnuogpqn	188	8	these	these	DT
cord-341050-hnuogpqn	188	9	approaches	approach	NNS
cord-341050-hnuogpqn	188	10	show	show	VBP
cord-341050-hnuogpqn	188	11	anti	anti	JJ
cord-341050-hnuogpqn	188	12	-	-	JJ
cord-341050-hnuogpqn	188	13	WNV	wnv	JJ
cord-341050-hnuogpqn	188	14	activity	activity	NN
cord-341050-hnuogpqn	188	15	in	in	IN
cord-341050-hnuogpqn	188	16	cell	cell	NN
cord-341050-hnuogpqn	188	17	-	-	HYPH
cord-341050-hnuogpqn	188	18	based	base	VBN
cord-341050-hnuogpqn	188	19	assays	assay	NNS
cord-341050-hnuogpqn	188	20	[	[	-LRB-
cord-341050-hnuogpqn	188	21	62	62	CD
cord-341050-hnuogpqn	188	22	,	,	,
cord-341050-hnuogpqn	188	23	206	206	CD
cord-341050-hnuogpqn	188	24	,	,	,
cord-341050-hnuogpqn	188	25	242	242	CD
cord-341050-hnuogpqn	188	26	]	]	-RRB-
cord-341050-hnuogpqn	188	27	,	,	,
cord-341050-hnuogpqn	188	28	none	none	NN
cord-341050-hnuogpqn	188	29	of	of	IN
cord-341050-hnuogpqn	188	30	the	the	DT
cord-341050-hnuogpqn	188	31	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	188	32	has	have	VBZ
cord-341050-hnuogpqn	188	33	progressed	progress	VBN
cord-341050-hnuogpqn	188	34	beyond	beyond	IN
cord-341050-hnuogpqn	188	35	the	the	DT
cord-341050-hnuogpqn	188	36	hit	hit	NN
cord-341050-hnuogpqn	188	37	optimization	optimization	NN
cord-341050-hnuogpqn	188	38	stage	stage	NN
cord-341050-hnuogpqn	188	39	.	.	.
cord-341050-hnuogpqn	189	1	Discovery	discovery	NN
cord-341050-hnuogpqn	189	2	of	of	IN
cord-341050-hnuogpqn	189	3	NS2B	NS2B	NNP
cord-341050-hnuogpqn	189	4	/	/	SYM
cord-341050-hnuogpqn	189	5	NS3	ns3	RB
cord-341050-hnuogpqn	189	6	protease	protease	NN
cord-341050-hnuogpqn	189	7	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	189	8	has	have	VBZ
cord-341050-hnuogpqn	189	9	been	be	VBN
cord-341050-hnuogpqn	189	10	hampered	hamper	VBN
cord-341050-hnuogpqn	189	11	largely	largely	RB
cord-341050-hnuogpqn	189	12	due	due	JJ
cord-341050-hnuogpqn	189	13	to	to	IN
cord-341050-hnuogpqn	189	14	the	the	DT
cord-341050-hnuogpqn	189	15	diffi	diffi	NNP
cord-341050-hnuogpqn	189	16	culties	cultie	NNS
cord-341050-hnuogpqn	189	17	in	in	IN
cord-341050-hnuogpqn	189	18	obtaining	obtain	VBG
cord-341050-hnuogpqn	189	19	co	co	JJ
cord-341050-hnuogpqn	189	20	-	-	JJ
cord-341050-hnuogpqn	189	21	crystal	crystal	JJ
cord-341050-hnuogpqn	189	22	structures	structure	NNS
cord-341050-hnuogpqn	189	23	of	of	IN
cord-341050-hnuogpqn	189	24	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	189	25	-	-	HYPH
cord-341050-hnuogpqn	189	26	protease	protease	NN
cord-341050-hnuogpqn	189	27	complexes	complex	NNS
cord-341050-hnuogpqn	189	28	.	.	.
cord-341050-hnuogpqn	190	1	Moreover	moreover	RB
cord-341050-hnuogpqn	190	2	,	,	,
cord-341050-hnuogpqn	190	3	because	because	IN
cord-341050-hnuogpqn	190	4	of	of	IN
cord-341050-hnuogpqn	190	5	the	the	DT
cord-341050-hnuogpqn	190	6	weak	weak	JJ
cord-341050-hnuogpqn	190	7	binding	bind	VBG
cord-341050-hnuogpqn	190	8	affi	affi	FW
cord-341050-hnuogpqn	190	9	nity	nity	NN
cord-341050-hnuogpqn	190	10	of	of	IN
cord-341050-hnuogpqn	190	11	NS2B	NS2B	NNP
cord-341050-hnuogpqn	190	12	/	/	SYM
cord-341050-hnuogpqn	190	13	NS3	ns3	RB
cord-341050-hnuogpqn	190	14	active	active	JJ
cord-341050-hnuogpqn	190	15	site	site	NN
cord-341050-hnuogpqn	190	16	due	due	IN
cord-341050-hnuogpqn	190	17	to	to	IN
cord-341050-hnuogpqn	190	18	its	-PRON-	PRP$
cord-341050-hnuogpqn	190	19	fl	fl	NNP
cord-341050-hnuogpqn	190	20	at	at	IN
cord-341050-hnuogpqn	190	21	and	and	CC
cord-341050-hnuogpqn	190	22	charged	charge	VBD
cord-341050-hnuogpqn	190	23	nature	nature	NN
cord-341050-hnuogpqn	190	24	,	,	,
cord-341050-hnuogpqn	190	25	the	the	DT
cord-341050-hnuogpqn	190	26	design	design	NN
cord-341050-hnuogpqn	190	27	of	of	IN
cord-341050-hnuogpqn	190	28	potent	potent	JJ
cord-341050-hnuogpqn	190	29	small	small	JJ
cord-341050-hnuogpqn	190	30	molecule	molecule	NN
cord-341050-hnuogpqn	190	31	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	190	32	by	by	IN
cord-341050-hnuogpqn	190	33	structurebased	structurebase	VBN
cord-341050-hnuogpqn	190	34	method	method	NN
cord-341050-hnuogpqn	190	35	becomes	become	VBZ
cord-341050-hnuogpqn	190	36	diffi	diffi	NNP
cord-341050-hnuogpqn	190	37	cult	cult	NN
cord-341050-hnuogpqn	190	38	[	[	-LRB-
cord-341050-hnuogpqn	190	39	53	53	CD
cord-341050-hnuogpqn	190	40	,	,	,
cord-341050-hnuogpqn	190	41	242	242	CD
cord-341050-hnuogpqn	190	42	,	,	,
cord-341050-hnuogpqn	190	43	250	250	CD
cord-341050-hnuogpqn	190	44	,	,	,
cord-341050-hnuogpqn	190	45	251	251	CD
cord-341050-hnuogpqn	190	46	]	]	-RRB-
cord-341050-hnuogpqn	190	47	.	.	.
cord-341050-hnuogpqn	191	1	The	the	DT
cord-341050-hnuogpqn	191	2	helicases	helicase	NNS
cord-341050-hnuogpqn	191	3	are	be	VBP
cord-341050-hnuogpqn	191	4	enzymes	enzyme	NNS
cord-341050-hnuogpqn	191	5	that	that	WDT
cord-341050-hnuogpqn	191	6	unwind	unwind	VBP
cord-341050-hnuogpqn	191	7	nucleic	nucleic	JJ
cord-341050-hnuogpqn	191	8	acid	acid	NN
cord-341050-hnuogpqn	191	9	by	by	IN
cord-341050-hnuogpqn	191	10	using	use	VBG
cord-341050-hnuogpqn	191	11	energy	energy	NN
cord-341050-hnuogpqn	191	12	derived	derive	VBN
cord-341050-hnuogpqn	191	13	from	from	IN
cord-341050-hnuogpqn	191	14	hydrolysis	hydrolysis	NN
cord-341050-hnuogpqn	191	15	of	of	IN
cord-341050-hnuogpqn	191	16	NTP	NTP	NNP
cord-341050-hnuogpqn	191	17	.	.	.
cord-341050-hnuogpqn	192	1	The	the	DT
cord-341050-hnuogpqn	192	2	C	c	NN
cord-341050-hnuogpqn	192	3	-	-	HYPH
cord-341050-hnuogpqn	192	4	terminal	terminal	NN
cord-341050-hnuogpqn	192	5	domain	domain	NN
cord-341050-hnuogpqn	192	6	of	of	IN
cord-341050-hnuogpqn	192	7	NS3	ns3	DT
cord-341050-hnuogpqn	192	8	of	of	IN
cord-341050-hnuogpqn	192	9	WNV	WNV	NNP
cord-341050-hnuogpqn	192	10	contains	contain	VBZ
cord-341050-hnuogpqn	192	11	helicase	helicase	NN
cord-341050-hnuogpqn	192	12	/	/	SYM
cord-341050-hnuogpqn	192	13	nuclease	nuclease	NN
cord-341050-hnuogpqn	192	14	activities	activity	NNS
cord-341050-hnuogpqn	192	15	and	and	CC
cord-341050-hnuogpqn	192	16	plays	play	VBZ
cord-341050-hnuogpqn	192	17	important	important	JJ
cord-341050-hnuogpqn	192	18	roles	role	NNS
cord-341050-hnuogpqn	192	19	in	in	IN
cord-341050-hnuogpqn	192	20	virulence	virulence	NN
cord-341050-hnuogpqn	192	21	and	and	CC
cord-341050-hnuogpqn	192	22	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	192	23	[	[	-LRB-
cord-341050-hnuogpqn	192	24	252	252	CD
cord-341050-hnuogpqn	192	25	-254	-254	NN
cord-341050-hnuogpqn	192	26	]	]	-RRB-
cord-341050-hnuogpqn	192	27	.	.	.
cord-341050-hnuogpqn	193	1	High	high	JJ
cord-341050-hnuogpqn	193	2	throughput	throughput	NN
cord-341050-hnuogpqn	193	3	assays	assay	NNS
cord-341050-hnuogpqn	193	4	that	that	WDT
cord-341050-hnuogpqn	193	5	measure	measure	VBP
cord-341050-hnuogpqn	193	6	helicase	helicase	NN
cord-341050-hnuogpqn	193	7	activity	activity	NN
cord-341050-hnuogpqn	193	8	by	by	IN
cord-341050-hnuogpqn	193	9	monitoring	monitor	VBG
cord-341050-hnuogpqn	193	10	helicase	helicase	NN
cord-341050-hnuogpqn	193	11	-	-	HYPH
cord-341050-hnuogpqn	193	12	catalyzed	catalyze	VBN
cord-341050-hnuogpqn	193	13	strand	strand	NN
cord-341050-hnuogpqn	193	14	separation	separation	NN
cord-341050-hnuogpqn	193	15	in	in	IN
cord-341050-hnuogpqn	193	16	real	real	JJ
cord-341050-hnuogpqn	193	17	-	-	HYPH
cord-341050-hnuogpqn	193	18	time	time	NN
cord-341050-hnuogpqn	193	19	by	by	IN
cord-341050-hnuogpqn	193	20	using	use	VBG
cord-341050-hnuogpqn	193	21	radioactive	radioactive	JJ
cord-341050-hnuogpqn	193	22	or	or	CC
cord-341050-hnuogpqn	193	23	fl	fl	NNP
cord-341050-hnuogpqn	193	24	uorescent	uorescent	RB
cord-341050-hnuogpqn	193	25	-	-	HYPH
cord-341050-hnuogpqn	193	26	labeled	label	VBN
cord-341050-hnuogpqn	193	27	oligonucleotides	oligonucleotide	NNS
cord-341050-hnuogpqn	193	28	have	have	VBP
cord-341050-hnuogpqn	193	29	been	be	VBN
cord-341050-hnuogpqn	193	30	developed	develop	VBN
cord-341050-hnuogpqn	193	31	to	to	IN
cord-341050-hnuogpqn	193	32	screen	screen	NN
cord-341050-hnuogpqn	193	33	helicase	helicase	NN
cord-341050-hnuogpqn	193	34	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	193	35	[	[	-LRB-
cord-341050-hnuogpqn	193	36	255	255	CD
cord-341050-hnuogpqn	193	37	-258	-258	NN
cord-341050-hnuogpqn	193	38	]	]	-RRB-
cord-341050-hnuogpqn	193	39	.	.	.
cord-341050-hnuogpqn	194	1	Several	several	JJ
cord-341050-hnuogpqn	194	2	small	small	JJ
cord-341050-hnuogpqn	194	3	molecule	molecule	NN
cord-341050-hnuogpqn	194	4	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	194	5	targeting	target	VBG
cord-341050-hnuogpqn	194	6	helicase	helicase	NNP
cord-341050-hnuogpqn	194	7	of	of	IN
cord-341050-hnuogpqn	194	8	HCV	HCV	NNP
cord-341050-hnuogpqn	194	9	and	and	CC
cord-341050-hnuogpqn	194	10	HIV-1	HIV-1	NNP
cord-341050-hnuogpqn	194	11	have	have	VBP
cord-341050-hnuogpqn	194	12	been	be	VBN
cord-341050-hnuogpqn	194	13	developed	develop	VBN
cord-341050-hnuogpqn	194	14	[	[	-LRB-
cord-341050-hnuogpqn	194	15	259	259	CD
cord-341050-hnuogpqn	194	16	]	]	-RRB-
cord-341050-hnuogpqn	194	17	.	.	.
cord-341050-hnuogpqn	195	1	By	by	IN
cord-341050-hnuogpqn	195	2	using	use	VBG
cord-341050-hnuogpqn	195	3	the	the	DT
cord-341050-hnuogpqn	195	4	substratebased	substratebased	JJ
cord-341050-hnuogpqn	195	5	assay	assay	NN
cord-341050-hnuogpqn	195	6	,	,	,
cord-341050-hnuogpqn	195	7	a	a	DT
cord-341050-hnuogpqn	195	8	few	few	JJ
cord-341050-hnuogpqn	195	9	compounds	compound	NNS
cord-341050-hnuogpqn	195	10	have	have	VBP
cord-341050-hnuogpqn	195	11	been	be	VBN
cord-341050-hnuogpqn	195	12	identifi	identifi	VBN
cord-341050-hnuogpqn	195	13	ed	ed	NN
cord-341050-hnuogpqn	195	14	and	and	CC
cord-341050-hnuogpqn	195	15	evaluated	evaluate	VBN
cord-341050-hnuogpqn	195	16	in	in	IN
cord-341050-hnuogpqn	195	17	vitro	vitro	FW
cord-341050-hnuogpqn	195	18	against	against	IN
cord-341050-hnuogpqn	195	19	NTPases	NTPases	NNP
cord-341050-hnuogpqn	195	20	/	/	SYM
cord-341050-hnuogpqn	195	21	helicases	helicase	NNS
cord-341050-hnuogpqn	195	22	of	of	IN
cord-341050-hnuogpqn	195	23	WNV	WNV	NNP
cord-341050-hnuogpqn	195	24	and	and	CC
cord-341050-hnuogpqn	195	25	other	other	JJ
cord-341050-hnuogpqn	195	26	fl	fl	NNP
cord-341050-hnuogpqn	195	27	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	195	28	[	[	-LRB-
cord-341050-hnuogpqn	195	29	260	260	CD
cord-341050-hnuogpqn	195	30	-262	-262	NNS
cord-341050-hnuogpqn	195	31	]	]	-RRB-
cord-341050-hnuogpqn	195	32	.	.	.
cord-341050-hnuogpqn	196	1	However	however	RB
cord-341050-hnuogpqn	196	2	,	,	,
cord-341050-hnuogpqn	196	3	inhibitory	inhibitory	JJ
cord-341050-hnuogpqn	196	4	effects	effect	NNS
cord-341050-hnuogpqn	196	5	of	of	IN
cord-341050-hnuogpqn	196	6	WNV	WNV	NNP
cord-341050-hnuogpqn	196	7	helicase	helicase	NN
cord-341050-hnuogpqn	196	8	by	by	IN
cord-341050-hnuogpqn	196	9	these	these	DT
cord-341050-hnuogpqn	196	10	compounds	compound	NNS
cord-341050-hnuogpqn	196	11	are	be	VBP
cord-341050-hnuogpqn	196	12	specifi	specifi	VBN
cord-341050-hnuogpqn	196	13	c	c	NN
cord-341050-hnuogpqn	196	14	to	to	IN
cord-341050-hnuogpqn	196	15	either	either	CC
cord-341050-hnuogpqn	196	16	DNA	DNA	NNP
cord-341050-hnuogpqn	196	17	or	or	CC
cord-341050-hnuogpqn	196	18	RNA	RNA	NNP
cord-341050-hnuogpqn	196	19	substrate	substrate	NN
cord-341050-hnuogpqn	196	20	.	.	.
cord-341050-hnuogpqn	197	1	For	for	IN
cord-341050-hnuogpqn	197	2	example	example	NN
cord-341050-hnuogpqn	197	3	,	,	,
cord-341050-hnuogpqn	197	4	a	a	DT
cord-341050-hnuogpqn	197	5	compound	compound	NN
cord-341050-hnuogpqn	197	6	named	name	VBN
cord-341050-hnuogpqn	197	7	4,5,6,7-tetrabromobenzotriazole	4,5,6,7-tetrabromobenzotriazole	CD
cord-341050-hnuogpqn	197	8	NS3	NS3	NNP
cord-341050-hnuogpqn	197	9	Helicase	Helicase	NNP
cord-341050-hnuogpqn	197	10	/	/	SYM
cord-341050-hnuogpqn	197	11	Nuclease	Nuclease	NNP
cord-341050-hnuogpqn	197	12	Inhibitors	Inhibitors	NNP
cord-341050-hnuogpqn	197	13	Treatment	Treatment	NNP
cord-341050-hnuogpqn	197	14	and	and	CC
cord-341050-hnuogpqn	197	15	Prevention	Prevention	NNP
cord-341050-hnuogpqn	197	16	Approaches	Approaches	NNPS
cord-341050-hnuogpqn	197	17	for	for	IN
cord-341050-hnuogpqn	197	18	WNV	WNV	NNP
cord-341050-hnuogpqn	197	19	268	268	CD
cord-341050-hnuogpqn	197	20	(	(	-LRB-
cord-341050-hnuogpqn	197	21	TBBT	TBBT	NNP
cord-341050-hnuogpqn	197	22	)	)	-RRB-
cord-341050-hnuogpqn	197	23	,	,	,
cord-341050-hnuogpqn	197	24	a	a	DT
cord-341050-hnuogpqn	197	25	halogenated	halogenate	VBN
cord-341050-hnuogpqn	197	26	benzotriazole	benzotriazole	NN
cord-341050-hnuogpqn	197	27	,	,	,
cord-341050-hnuogpqn	197	28	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	197	29	NS3	ns3	RB
cord-341050-hnuogpqn	197	30	helicase	helicase	NN
cord-341050-hnuogpqn	197	31	,	,	,
cord-341050-hnuogpqn	197	32	but	but	CC
cord-341050-hnuogpqn	197	33	not	not	RB
cord-341050-hnuogpqn	197	34	NTPase	NTPase	NNP
cord-341050-hnuogpqn	197	35	activity	activity	NN
cord-341050-hnuogpqn	197	36	[	[	-LRB-
cord-341050-hnuogpqn	197	37	260	260	CD
cord-341050-hnuogpqn	197	38	]	]	-RRB-
cord-341050-hnuogpqn	197	39	.	.	.
cord-341050-hnuogpqn	198	1	A	a	DT
cord-341050-hnuogpqn	198	2	series	series	NN
cord-341050-hnuogpqn	198	3	of	of	IN
cord-341050-hnuogpqn	198	4	ring	ring	NN
cord-341050-hnuogpqn	198	5	-	-	HYPH
cord-341050-hnuogpqn	198	6	expanded	expand	VBN
cord-341050-hnuogpqn	198	7	nucleoside/	nucleoside/	CD
cord-341050-hnuogpqn	198	8	nucleotide	nucleotide	JJ
cord-341050-hnuogpqn	198	9	analogs	analog	NNS
cord-341050-hnuogpqn	198	10	(	(	-LRB-
cord-341050-hnuogpqn	198	11	RENs	ren	NNS
cord-341050-hnuogpqn	198	12	)	)	-RRB-
cord-341050-hnuogpqn	198	13	also	also	RB
cord-341050-hnuogpqn	198	14	inhibit	inhibit	VB
cord-341050-hnuogpqn	198	15	NTPases	ntpase	NNS
cord-341050-hnuogpqn	198	16	/	/	SYM
cord-341050-hnuogpqn	198	17	helicases	helicase	NNS
cord-341050-hnuogpqn	198	18	activities	activity	NNS
cord-341050-hnuogpqn	198	19	of	of	IN
cord-341050-hnuogpqn	198	20	fl	fl	NNP
cord-341050-hnuogpqn	198	21	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	198	22	,	,	,
cord-341050-hnuogpqn	198	23	including	include	VBG
cord-341050-hnuogpqn	198	24	WNV	WNV	NNP
cord-341050-hnuogpqn	198	25	,	,	,
cord-341050-hnuogpqn	198	26	HCV	HCV	NNP
cord-341050-hnuogpqn	198	27	,	,	,
cord-341050-hnuogpqn	198	28	and	and	CC
cord-341050-hnuogpqn	198	29	JEV	JEV	NNP
cord-341050-hnuogpqn	198	30	[	[	-LRB-
cord-341050-hnuogpqn	198	31	263	263	CD
cord-341050-hnuogpqn	198	32	,	,	,
cord-341050-hnuogpqn	198	33	264	264	CD
cord-341050-hnuogpqn	198	34	]	]	-RRB-
cord-341050-hnuogpqn	198	35	,	,	,
cord-341050-hnuogpqn	198	36	however	however	RB
cord-341050-hnuogpqn	198	37	,	,	,
cord-341050-hnuogpqn	198	38	these	these	DT
cord-341050-hnuogpqn	198	39	compounds	compound	NNS
cord-341050-hnuogpqn	198	40	did	do	VBD
cord-341050-hnuogpqn	198	41	not	not	RB
cord-341050-hnuogpqn	198	42	show	show	VB
cord-341050-hnuogpqn	198	43	any	any	DT
cord-341050-hnuogpqn	198	44	promising	promising	JJ
cord-341050-hnuogpqn	198	45	anti	anti	JJ
cord-341050-hnuogpqn	198	46	-	-	JJ
cord-341050-hnuogpqn	198	47	WNV	wnv	JJ
cord-341050-hnuogpqn	198	48	activity	activity	NN
cord-341050-hnuogpqn	198	49	in	in	IN
cord-341050-hnuogpqn	198	50	cell	cell	NN
cord-341050-hnuogpqn	198	51	culture	culture	NN
cord-341050-hnuogpqn	198	52	.	.	.
cord-341050-hnuogpqn	199	1	A	a	DT
cord-341050-hnuogpqn	199	2	nucleoside	nucleoside	NN
cord-341050-hnuogpqn	199	3	analog	analog	NN
cord-341050-hnuogpqn	199	4	imidazo[4,5-d]pyridazine	imidazo[4,5-d]pyridazine	PRP$
cord-341050-hnuogpqn	199	5	nucleosides	nucleoside	VBZ
cord-341050-hnuogpqn	199	6	[	[	-LRB-
cord-341050-hnuogpqn	199	7	265	265	CD
cord-341050-hnuogpqn	199	8	]	]	-RRB-
cord-341050-hnuogpqn	199	9	,	,	,
cord-341050-hnuogpqn	199	10	and	and	CC
cord-341050-hnuogpqn	199	11	a	a	DT
cord-341050-hnuogpqn	199	12	broad	broad	JJ
cord-341050-hnuogpqn	199	13	-	-	HYPH
cord-341050-hnuogpqn	199	14	spectrum	spectrum	NN
cord-341050-hnuogpqn	199	15	antiparasitic	antiparasitic	JJ
cord-341050-hnuogpqn	199	16	drug	drug	NN
cord-341050-hnuogpqn	199	17	named	name	VBN
cord-341050-hnuogpqn	199	18	ivermectin	ivermectin	NNP
cord-341050-hnuogpqn	199	19	[	[	-LRB-
cord-341050-hnuogpqn	199	20	266	266	CD
cord-341050-hnuogpqn	199	21	]	]	-RRB-
cord-341050-hnuogpqn	200	1	inhibit	inhibit	NN
cord-341050-hnuogpqn	200	2	NS3	ns3	RB
cord-341050-hnuogpqn	200	3	helicase	helicase	VBG
cord-341050-hnuogpqn	200	4	and	and	CC
cord-341050-hnuogpqn	200	5	also	also	RB
cord-341050-hnuogpqn	200	6	show	show	VB
cord-341050-hnuogpqn	200	7	anti	anti	JJ
cord-341050-hnuogpqn	200	8	-	-	JJ
cord-341050-hnuogpqn	200	9	WNV	wnv	JJ
cord-341050-hnuogpqn	200	10	activity	activity	NN
cord-341050-hnuogpqn	200	11	in	in	IN
cord-341050-hnuogpqn	200	12	cell	cell	NN
cord-341050-hnuogpqn	200	13	culture	culture	NN
cord-341050-hnuogpqn	200	14	.	.	.
cord-341050-hnuogpqn	201	1	The	the	DT
cord-341050-hnuogpqn	201	2	RNA	RNA	NNP
cord-341050-hnuogpqn	201	3	-	-	HYPH
cord-341050-hnuogpqn	201	4	dependent	dependent	JJ
cord-341050-hnuogpqn	201	5	RNA	RNA	NNP
cord-341050-hnuogpqn	201	6	polymerase	polymerase	NN
cord-341050-hnuogpqn	201	7	(	(	-LRB-
cord-341050-hnuogpqn	201	8	RdRp	RdRp	NNP
cord-341050-hnuogpqn	201	9	)	)	-RRB-
cord-341050-hnuogpqn	201	10	activity	activity	NN
cord-341050-hnuogpqn	201	11	of	of	IN
cord-341050-hnuogpqn	201	12	C	c	NN
cord-341050-hnuogpqn	201	13	-	-	HYPH
cord-341050-hnuogpqn	201	14	terminal	terminal	NN
cord-341050-hnuogpqn	201	15	NS5	ns5	JJ
cord-341050-hnuogpqn	201	16	protein	protein	NN
cord-341050-hnuogpqn	201	17	of	of	IN
cord-341050-hnuogpqn	201	18	WNV	WNV	NNP
cord-341050-hnuogpqn	201	19	and	and	CC
cord-341050-hnuogpqn	201	20	other	other	JJ
cord-341050-hnuogpqn	201	21	fl	fl	NNP
cord-341050-hnuogpqn	201	22	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	201	23	is	be	VBZ
cord-341050-hnuogpqn	201	24	an	an	DT
cord-341050-hnuogpqn	201	25	attractive	attractive	JJ
cord-341050-hnuogpqn	201	26	target	target	NN
cord-341050-hnuogpqn	201	27	for	for	IN
cord-341050-hnuogpqn	201	28	developing	develop	VBG
cord-341050-hnuogpqn	201	29	antiviral	antiviral	JJ
cord-341050-hnuogpqn	201	30	agents	agent	NNS
cord-341050-hnuogpqn	201	31	[	[	-LRB-
cord-341050-hnuogpqn	201	32	55	55	CD
cord-341050-hnuogpqn	201	33	,	,	,
cord-341050-hnuogpqn	201	34	267	267	CD
cord-341050-hnuogpqn	201	35	-269	-269	NN
cord-341050-hnuogpqn	201	36	]	]	-RRB-
cord-341050-hnuogpqn	201	37	.	.	.
cord-341050-hnuogpqn	202	1	Two	two	CD
cord-341050-hnuogpqn	202	2	approaches	approach	NNS
cord-341050-hnuogpqn	202	3	used	use	VBN
cord-341050-hnuogpqn	202	4	to	to	TO
cord-341050-hnuogpqn	202	5	target	target	VB
cord-341050-hnuogpqn	202	6	WNV	WNV	NNP
cord-341050-hnuogpqn	202	7	RdRp	RdRp	NNP
cord-341050-hnuogpqn	203	1	include	include	VBP
cord-341050-hnuogpqn	203	2	nucleoside	nucleoside	NN
cord-341050-hnuogpqn	203	3	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	203	4	(	(	-LRB-
cord-341050-hnuogpqn	203	5	NIs	NIs	NNP
cord-341050-hnuogpqn	203	6	)	)	-RRB-
cord-341050-hnuogpqn	203	7	or	or	CC
cord-341050-hnuogpqn	203	8	non	non	JJ
cord-341050-hnuogpqn	203	9	-	-	JJ
cord-341050-hnuogpqn	203	10	nucleosides	nucleosides	JJ
cord-341050-hnuogpqn	203	11	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	203	12	(	(	-LRB-
cord-341050-hnuogpqn	203	13	NNIs	nni	NNS
cord-341050-hnuogpqn	203	14	)	)	-RRB-
cord-341050-hnuogpqn	203	15	.	.	.
cord-341050-hnuogpqn	204	1	NIs	NIs	NNP
cord-341050-hnuogpqn	204	2	(	(	-LRB-
cord-341050-hnuogpqn	204	3	also	also	RB
cord-341050-hnuogpqn	204	4	known	know	VBN
cord-341050-hnuogpqn	204	5	as	as	IN
cord-341050-hnuogpqn	204	6	type	type	NN
cord-341050-hnuogpqn	204	7	1	1	CD
cord-341050-hnuogpqn	204	8	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	204	9	)	)	-RRB-
cord-341050-hnuogpqn	204	10	are	be	VBP
cord-341050-hnuogpqn	204	11	nucleoside	nucleoside	NN
cord-341050-hnuogpqn	204	12	/	/	SYM
cord-341050-hnuogpqn	204	13	nucleotide	nucleotide	JJ
cord-341050-hnuogpqn	204	14	analogs	analog	NNS
cord-341050-hnuogpqn	204	15	that	that	WDT
cord-341050-hnuogpqn	204	16	target	target	VBP
cord-341050-hnuogpqn	204	17	the	the	DT
cord-341050-hnuogpqn	204	18	active	active	JJ
cord-341050-hnuogpqn	204	19	sites	site	NNS
cord-341050-hnuogpqn	204	20	of	of	IN
cord-341050-hnuogpqn	204	21	the	the	DT
cord-341050-hnuogpqn	204	22	polymerase	polymerase	NN
cord-341050-hnuogpqn	204	23	and	and	CC
cord-341050-hnuogpqn	204	24	generally	generally	RB
cord-341050-hnuogpqn	204	25	compete	compete	VBP
cord-341050-hnuogpqn	204	26	with	with	IN
cord-341050-hnuogpqn	204	27	natural	natural	JJ
cord-341050-hnuogpqn	204	28	NTP	NTP	NNP
cord-341050-hnuogpqn	204	29	substrates	substrate	NNS
cord-341050-hnuogpqn	204	30	of	of	IN
cord-341050-hnuogpqn	204	31	RdRp	RdRp	NNP
cord-341050-hnuogpqn	204	32	to	to	TO
cord-341050-hnuogpqn	204	33	block	block	VB
cord-341050-hnuogpqn	204	34	their	-PRON-	PRP$
cord-341050-hnuogpqn	204	35	incorporation	incorporation	NN
cord-341050-hnuogpqn	204	36	into	into	IN
cord-341050-hnuogpqn	204	37	viral	viral	JJ
cord-341050-hnuogpqn	204	38	genome	genome	NN
cord-341050-hnuogpqn	204	39	during	during	IN
cord-341050-hnuogpqn	204	40	replication	replication	NN
cord-341050-hnuogpqn	204	41	and	and	CC
cord-341050-hnuogpqn	204	42	lead	lead	VB
cord-341050-hnuogpqn	204	43	to	to	IN
cord-341050-hnuogpqn	204	44	incomplete	incomplete	JJ
cord-341050-hnuogpqn	204	45	replication	replication	NN
cord-341050-hnuogpqn	204	46	or	or	CC
cord-341050-hnuogpqn	204	47	mutations	mutation	NNS
cord-341050-hnuogpqn	204	48	of	of	IN
cord-341050-hnuogpqn	204	49	viral	viral	JJ
cord-341050-hnuogpqn	204	50	genome	genome	NN
cord-341050-hnuogpqn	204	51	.	.	.
cord-341050-hnuogpqn	205	1	The	the	DT
cord-341050-hnuogpqn	205	2	success	success	NN
cord-341050-hnuogpqn	205	3	of	of	IN
cord-341050-hnuogpqn	205	4	NIs	NIs	NNP
cord-341050-hnuogpqn	205	5	against	against	IN
cord-341050-hnuogpqn	205	6	several	several	JJ
cord-341050-hnuogpqn	205	7	viruses	virus	NNS
cord-341050-hnuogpqn	205	8	including	include	VBG
cord-341050-hnuogpqn	205	9	HIV-1	HIV-1	NNP
cord-341050-hnuogpqn	205	10	,	,	,
cord-341050-hnuogpqn	205	11	herpesviruses	herpesviruses	NNP
cord-341050-hnuogpqn	205	12	,	,	,
cord-341050-hnuogpqn	205	13	HBV	HBV	NNP
cord-341050-hnuogpqn	205	14	,	,	,
cord-341050-hnuogpqn	205	15	and	and	CC
cord-341050-hnuogpqn	205	16	HCV	HCV	NNP
cord-341050-hnuogpqn	205	17	has	have	VBZ
cord-341050-hnuogpqn	205	18	already	already	RB
cord-341050-hnuogpqn	205	19	proved	prove	VBN
cord-341050-hnuogpqn	205	20	the	the	DT
cord-341050-hnuogpqn	205	21	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	205	22	potential	potential	NN
cord-341050-hnuogpqn	205	23	of	of	IN
cord-341050-hnuogpqn	205	24	this	this	DT
cord-341050-hnuogpqn	205	25	class	class	NN
cord-341050-hnuogpqn	205	26	of	of	IN
cord-341050-hnuogpqn	205	27	compounds	compound	NNS
cord-341050-hnuogpqn	205	28	[	[	-LRB-
cord-341050-hnuogpqn	205	29	270	270	CD
cord-341050-hnuogpqn	205	30	-272	-272	NN
cord-341050-hnuogpqn	205	31	]	]	-RRB-
cord-341050-hnuogpqn	205	32	.	.	.
cord-341050-hnuogpqn	206	1	In	in	IN
cord-341050-hnuogpqn	206	2	addition	addition	NN
cord-341050-hnuogpqn	206	3	,	,	,
cord-341050-hnuogpqn	206	4	NI	NI	NNP
cord-341050-hnuogpqn	206	5	generally	generally	RB
cord-341050-hnuogpqn	206	6	displays	display	VBZ
cord-341050-hnuogpqn	206	7	broad	broad	JJ
cord-341050-hnuogpqn	206	8	-	-	HYPH
cord-341050-hnuogpqn	206	9	spectrum	spectrum	NN
cord-341050-hnuogpqn	206	10	antiviral	antiviral	JJ
cord-341050-hnuogpqn	206	11	activities	activity	NNS
cord-341050-hnuogpqn	206	12	across	across	IN
cord-341050-hnuogpqn	206	13	related	relate	VBN
cord-341050-hnuogpqn	206	14	RNA	RNA	NNP
cord-341050-hnuogpqn	206	15	viruses	virus	NNS
cord-341050-hnuogpqn	206	16	suggesting	suggest	VBG
cord-341050-hnuogpqn	206	17	its	-PRON-	PRP$
cord-341050-hnuogpqn	206	18	potential	potential	NN
cord-341050-hnuogpqn	206	19	as	as	IN
cord-341050-hnuogpqn	206	20	pan	pan	NNP
cord-341050-hnuogpqn	206	21	-	-	JJ
cord-341050-hnuogpqn	206	22	fl	fl	JJ
cord-341050-hnuogpqn	206	23	aviviral	aviviral	JJ
cord-341050-hnuogpqn	206	24	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	206	25	.	.	.
cord-341050-hnuogpqn	207	1	Various	various	JJ
cord-341050-hnuogpqn	207	2	cell	cell	NN
cord-341050-hnuogpqn	207	3	-	-	HYPH
cord-341050-hnuogpqn	207	4	based	base	VBN
cord-341050-hnuogpqn	207	5	and	and	CC
cord-341050-hnuogpqn	207	6	cell	cell	NN
cord-341050-hnuogpqn	207	7	-	-	HYPH
cord-341050-hnuogpqn	207	8	free	free	JJ
cord-341050-hnuogpqn	207	9	assays	assay	NNS
cord-341050-hnuogpqn	207	10	have	have	VBP
cord-341050-hnuogpqn	207	11	been	be	VBN
cord-341050-hnuogpqn	207	12	developed	develop	VBN
cord-341050-hnuogpqn	207	13	for	for	IN
cord-341050-hnuogpqn	207	14	high	high	JJ
cord-341050-hnuogpqn	207	15	-	-	HYPH
cord-341050-hnuogpqn	207	16	throughput	throughput	NN
cord-341050-hnuogpqn	207	17	screening	screening	NN
cord-341050-hnuogpqn	207	18	of	of	IN
cord-341050-hnuogpqn	207	19	fl	fl	NNP
cord-341050-hnuogpqn	207	20	aviviral	aviviral	NNP
cord-341050-hnuogpqn	207	21	RdRp	RdRp	NNP
cord-341050-hnuogpqn	207	22	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	207	23	[	[	-LRB-
cord-341050-hnuogpqn	207	24	273	273	CD
cord-341050-hnuogpqn	207	25	-276	-276	NN
cord-341050-hnuogpqn	207	26	]	]	-RRB-
cord-341050-hnuogpqn	207	27	.	.	.
cord-341050-hnuogpqn	208	1	So	so	RB
cord-341050-hnuogpqn	208	2	far	far	RB
cord-341050-hnuogpqn	208	3	,	,	,
cord-341050-hnuogpqn	208	4	several	several	JJ
cord-341050-hnuogpqn	208	5	NIs	ni	NNS
cord-341050-hnuogpqn	208	6	that	that	WDT
cord-341050-hnuogpqn	208	7	inhibit	inhibit	VBP
cord-341050-hnuogpqn	208	8	WNV	WNV	NNP
cord-341050-hnuogpqn	208	9	,	,	,
cord-341050-hnuogpqn	208	10	DENV	DENV	NNP
cord-341050-hnuogpqn	208	11	,	,	,
cord-341050-hnuogpqn	208	12	and	and	CC
cord-341050-hnuogpqn	208	13	other	other	JJ
cord-341050-hnuogpqn	208	14	RNA	RNA	NNP
cord-341050-hnuogpqn	208	15	viruses	virus	NNS
cord-341050-hnuogpqn	208	16	have	have	VBP
cord-341050-hnuogpqn	208	17	been	be	VBN
cord-341050-hnuogpqn	208	18	identifi	identifi	VBN
cord-341050-hnuogpqn	208	19	ed	ed	NNP
cord-341050-hnuogpqn	208	20	[	[	-LRB-
cord-341050-hnuogpqn	208	21	34	34	CD
cord-341050-hnuogpqn	208	22	]	]	-RRB-
cord-341050-hnuogpqn	208	23	.	.	.
cord-341050-hnuogpqn	209	1	For	for	IN
cord-341050-hnuogpqn	209	2	example	example	NN
cord-341050-hnuogpqn	209	3	,	,	,
cord-341050-hnuogpqn	209	4	favipiravir	favipiravir	NNP
cord-341050-hnuogpqn	209	5	(	(	-LRB-
cord-341050-hnuogpqn	209	6	T-705	t-705	NN
cord-341050-hnuogpqn	209	7	;	;	:
cord-341050-hnuogpqn	209	8	6-fl	6-fl	CD
cord-341050-hnuogpqn	209	9	uoro-3-hydroxy-2-pyrazinecarboxamide	uoro-3-hydroxy-2-pyrazinecarboxamide	JJ
cord-341050-hnuogpqn	209	10	)	)	-RRB-
cord-341050-hnuogpqn	209	11	and	and	CC
cord-341050-hnuogpqn	209	12	related	related	JJ
cord-341050-hnuogpqn	209	13	compounds	compound	NNS
cord-341050-hnuogpqn	209	14	selectively	selectively	RB
cord-341050-hnuogpqn	209	15	inhibit	inhibit	VBP
cord-341050-hnuogpqn	209	16	viral	viral	JJ
cord-341050-hnuogpqn	209	17	RNA	rna	NN
cord-341050-hnuogpqn	209	18	-	-	HYPH
cord-341050-hnuogpqn	209	19	dependent	dependent	JJ
cord-341050-hnuogpqn	209	20	RNA	RNA	NNP
cord-341050-hnuogpqn	209	21	polymerase	polymerase	NN
cord-341050-hnuogpqn	209	22	and	and	CC
cord-341050-hnuogpqn	209	23	have	have	VBP
cord-341050-hnuogpqn	209	24	potent	potent	JJ
cord-341050-hnuogpqn	209	25	anti	anti	JJ
cord-341050-hnuogpqn	209	26	-	-	JJ
cord-341050-hnuogpqn	209	27	infl	infl	JJ
cord-341050-hnuogpqn	209	28	uenza	uenza	NN
cord-341050-hnuogpqn	209	29	activity	activity	NN
cord-341050-hnuogpqn	209	30	[	[	-LRB-
cord-341050-hnuogpqn	209	31	277	277	CD
cord-341050-hnuogpqn	209	32	,	,	,
cord-341050-hnuogpqn	209	33	278	278	CD
cord-341050-hnuogpqn	209	34	]	]	-RRB-
cord-341050-hnuogpqn	209	35	.	.	.
cord-341050-hnuogpqn	210	1	This	this	DT
cord-341050-hnuogpqn	210	2	antiviral	antiviral	JJ
cord-341050-hnuogpqn	210	3	drug	drug	NN
cord-341050-hnuogpqn	210	4	is	be	VBZ
cord-341050-hnuogpqn	210	5	currently	currently	RB
cord-341050-hnuogpqn	210	6	being	be	VBG
cord-341050-hnuogpqn	210	7	evaluated	evaluate	VBN
cord-341050-hnuogpqn	210	8	in	in	IN
cord-341050-hnuogpqn	210	9	clinical	clinical	JJ
cord-341050-hnuogpqn	210	10	trials	trial	NNS
cord-341050-hnuogpqn	210	11	against	against	IN
cord-341050-hnuogpqn	210	12	infl	infl	NNP
cord-341050-hnuogpqn	210	13	uenza	uenza	NNP
cord-341050-hnuogpqn	210	14	virus	virus	NN
cord-341050-hnuogpqn	210	15	.	.	.
cord-341050-hnuogpqn	211	1	In	in	IN
cord-341050-hnuogpqn	211	2	addition	addition	NN
cord-341050-hnuogpqn	211	3	,	,	,
cord-341050-hnuogpqn	211	4	favipiravir	favipiravir	NNP
cord-341050-hnuogpqn	211	5	also	also	RB
cord-341050-hnuogpqn	211	6	blocks	block	VBZ
cord-341050-hnuogpqn	211	7	replication	replication	NN
cord-341050-hnuogpqn	211	8	of	of	IN
cord-341050-hnuogpqn	211	9	many	many	JJ
cord-341050-hnuogpqn	211	10	other	other	JJ
cord-341050-hnuogpqn	211	11	RNA	RNA	NNP
cord-341050-hnuogpqn	211	12	viruses	virus	NNS
cord-341050-hnuogpqn	211	13	,	,	,
cord-341050-hnuogpqn	211	14	including	include	VBG
cord-341050-hnuogpqn	211	15	WNV	WNV	NNP
cord-341050-hnuogpqn	211	16	and	and	CC
cord-341050-hnuogpqn	211	17	are	be	VBP
cord-341050-hnuogpqn	211	18	promising	promise	VBG
cord-341050-hnuogpqn	211	19	drug	drug	NN
cord-341050-hnuogpqn	211	20	candidate	candidate	NN
cord-341050-hnuogpqn	211	21	against	against	IN
cord-341050-hnuogpqn	211	22	a	a	DT
cord-341050-hnuogpqn	211	23	broad	broad	JJ
cord-341050-hnuogpqn	211	24	range	range	NN
cord-341050-hnuogpqn	211	25	of	of	IN
cord-341050-hnuogpqn	211	26	RNA	RNA	NNP
cord-341050-hnuogpqn	211	27	viral	viral	JJ
cord-341050-hnuogpqn	211	28	diseases	disease	NNS
cord-341050-hnuogpqn	211	29	[	[	-LRB-
cord-341050-hnuogpqn	211	30	279	279	CD
cord-341050-hnuogpqn	211	31	]	]	-RRB-
cord-341050-hnuogpqn	211	32	.	.	.
cord-341050-hnuogpqn	212	1	Two	two	CD
cord-341050-hnuogpqn	212	2	other	other	JJ
cord-341050-hnuogpqn	212	3	nucleoside	nucleoside	NN
cord-341050-hnuogpqn	212	4	analogs	analog	NNS
cord-341050-hnuogpqn	212	5	called	call	VBN
cord-341050-hnuogpqn	212	6	7-deaza-2′-C	7-deaza-2′-c	CD
cord-341050-hnuogpqn	212	7	-	-	HYPH
cord-341050-hnuogpqn	212	8	methyl	methyl	NN
cord-341050-hnuogpqn	212	9	-	-	HYPH
cord-341050-hnuogpqn	212	10	adenosine	adenosine	NN
cord-341050-hnuogpqn	212	11	and	and	CC
cord-341050-hnuogpqn	212	12	5-aza-7-deazaguanosine	5-aza-7-deazaguanosine	CD
cord-341050-hnuogpqn	212	13	(	(	-LRB-
cord-341050-hnuogpqn	212	14	ZX-2401	ZX-2401	NNP
cord-341050-hnuogpqn	212	15	)	)	-RRB-
cord-341050-hnuogpqn	212	16	,	,	,
cord-341050-hnuogpqn	212	17	which	which	WDT
cord-341050-hnuogpqn	212	18	are	be	VBP
cord-341050-hnuogpqn	212	19	the	the	DT
cord-341050-hnuogpqn	212	20	derivatives	derivative	NNS
cord-341050-hnuogpqn	212	21	of	of	IN
cord-341050-hnuogpqn	212	22	triphosphates	triphosphate	NNS
cord-341050-hnuogpqn	212	23	of	of	IN
cord-341050-hnuogpqn	212	24	2′-C	2′-c	CD
cord-341050-hnuogpqn	212	25	-	-	HYPH
cord-341050-hnuogpqn	212	26	methyl	methyl	NN
cord-341050-hnuogpqn	212	27	-	-	HYPH
cord-341050-hnuogpqn	212	28	adenosine	adenosine	NN
cord-341050-hnuogpqn	212	29	and	and	CC
cord-341050-hnuogpqn	212	30	2′-C	2′-c	CD
cord-341050-hnuogpqn	212	31	-	-	HYPH
cord-341050-hnuogpqn	212	32	methyl	methyl	NN
cord-341050-hnuogpqn	212	33	-	-	HYPH
cord-341050-hnuogpqn	212	34	guanosine	guanosine	NN
cord-341050-hnuogpqn	212	35	,	,	,
cord-341050-hnuogpqn	212	36	respectively	respectively	RB
cord-341050-hnuogpqn	212	37	,	,	,
cord-341050-hnuogpqn	212	38	are	be	VBP
cord-341050-hnuogpqn	212	39	also	also	RB
cord-341050-hnuogpqn	212	40	broad	broad	JJ
cord-341050-hnuogpqn	212	41	-	-	HYPH
cord-341050-hnuogpqn	212	42	spectrum	spectrum	NN
cord-341050-hnuogpqn	212	43	antiviral	antiviral	JJ
cord-341050-hnuogpqn	212	44	compounds	compound	NNS
cord-341050-hnuogpqn	212	45	targeting	target	VBG
cord-341050-hnuogpqn	212	46	viral	viral	JJ
cord-341050-hnuogpqn	212	47	RdRp	RdRp	NNP
cord-341050-hnuogpqn	212	48	that	that	WDT
cord-341050-hnuogpqn	212	49	inhibit	inhibit	VBP
cord-341050-hnuogpqn	212	50	DENV	DENV	NNP
cord-341050-hnuogpqn	212	51	,	,	,
cord-341050-hnuogpqn	212	52	HCV	HCV	NNP
cord-341050-hnuogpqn	212	53	and	and	CC
cord-341050-hnuogpqn	212	54	WNV	WNV	NNP
cord-341050-hnuogpqn	212	55	[	[	-LRB-
cord-341050-hnuogpqn	212	56	280	280	CD
cord-341050-hnuogpqn	212	57	-282	-282	NNS
cord-341050-hnuogpqn	212	58	]	]	-RRB-
cord-341050-hnuogpqn	212	59	.	.	.
cord-341050-hnuogpqn	213	1	Similarly	similarly	RB
cord-341050-hnuogpqn	213	2	,	,	,
cord-341050-hnuogpqn	213	3	two	two	CD
cord-341050-hnuogpqn	213	4	other	other	JJ
cord-341050-hnuogpqn	213	5	NI	NI	NNP
cord-341050-hnuogpqn	213	6	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	213	7	,	,	,
cord-341050-hnuogpqn	213	8	NITD-008	NITD-008	NNP
cord-341050-hnuogpqn	213	9	(	(	-LRB-
cord-341050-hnuogpqn	213	10	beta	beta	NN
cord-341050-hnuogpqn	213	11	-	-	HYPH
cord-341050-hnuogpqn	213	12	D-2′-ethynyl-7-deazaadenosine	d-2′-ethynyl-7-deazaadenosine	JJ
cord-341050-hnuogpqn	213	13	triphosphate	triphosphate	NN
cord-341050-hnuogpqn	213	14	)	)	-RRB-
cord-341050-hnuogpqn	213	15	and	and	CC
cord-341050-hnuogpqn	213	16	NITD203	NITD203	NNP
cord-341050-hnuogpqn	213	17	(	(	-LRB-
cord-341050-hnuogpqn	213	18	3′,5′-O	3′,5′-o	CD
cord-341050-hnuogpqn	213	19	-	-	HYPH
cord-341050-hnuogpqn	213	20	diisobutyryl-2′-Cacetylene-7-deaza-7-carbamoyladenosine	diisobutyryl-2′-cacetylene-7-deaza-7-carbamoyladenosine	NN
cord-341050-hnuogpqn	213	21	)	)	-RRB-
cord-341050-hnuogpqn	213	22	inhibit	inhibit	VBP
cord-341050-hnuogpqn	213	23	all	all	DT
cord-341050-hnuogpqn	213	24	four	four	CD
cord-341050-hnuogpqn	213	25	of	of	IN
cord-341050-hnuogpqn	213	26	DENV	DENV	NNP
cord-341050-hnuogpqn	213	27	serotypes	serotype	NNS
cord-341050-hnuogpqn	213	28	and	and	CC
cord-341050-hnuogpqn	213	29	WNV	WNV	NNP
cord-341050-hnuogpqn	213	30	.	.	.
cord-341050-hnuogpqn	214	1	In	in	IN
cord-341050-hnuogpqn	214	2	contrast	contrast	NN
cord-341050-hnuogpqn	214	3	to	to	IN
cord-341050-hnuogpqn	214	4	NI	NI	NNP
cord-341050-hnuogpqn	214	5	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	214	6	,	,	,
cord-341050-hnuogpqn	214	7	antiviral	antiviral	JJ
cord-341050-hnuogpqn	214	8	NNI	NNI	NNP
cord-341050-hnuogpqn	214	9	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	214	10	(	(	-LRB-
cord-341050-hnuogpqn	214	11	also	also	RB
cord-341050-hnuogpqn	214	12	known	know	VBN
cord-341050-hnuogpqn	214	13	as	as	IN
cord-341050-hnuogpqn	214	14	type	type	NN
cord-341050-hnuogpqn	214	15	2	2	CD
cord-341050-hnuogpqn	214	16	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	214	17	)	)	-RRB-
cord-341050-hnuogpqn	214	18	interfere	interfere	VBP
cord-341050-hnuogpqn	214	19	with	with	IN
cord-341050-hnuogpqn	214	20	the	the	DT
cord-341050-hnuogpqn	214	21	function	function	NN
cord-341050-hnuogpqn	214	22	of	of	IN
cord-341050-hnuogpqn	214	23	viral	viral	JJ
cord-341050-hnuogpqn	214	24	polymerase	polymerase	NN
cord-341050-hnuogpqn	214	25	by	by	IN
cord-341050-hnuogpqn	214	26	occupying	occupy	VBG
cord-341050-hnuogpqn	214	27	its	-PRON-	PRP$
cord-341050-hnuogpqn	214	28	allosteric	allosteric	JJ
cord-341050-hnuogpqn	214	29	sites	site	NNS
cord-341050-hnuogpqn	214	30	,	,	,
cord-341050-hnuogpqn	214	31	thus	thus	RB
cord-341050-hnuogpqn	214	32	preventing	prevent	VBG
cord-341050-hnuogpqn	214	33	viral	viral	JJ
cord-341050-hnuogpqn	214	34	Dhiraj	Dhiraj	NNP
cord-341050-hnuogpqn	214	35	Acharya	Acharya	NNP
cord-341050-hnuogpqn	214	36	and	and	CC
cord-341050-hnuogpqn	214	37	Fengwei	Fengwei	NNP
cord-341050-hnuogpqn	214	38	Bai	Bai	NNP
cord-341050-hnuogpqn	214	39	RNA	RNA	NNP
cord-341050-hnuogpqn	214	40	synthesis	synthesis	NN
cord-341050-hnuogpqn	214	41	.	.	.
cord-341050-hnuogpqn	215	1	Analysis	Analysis	NNP
cord-341050-hnuogpqn	215	2	of	of	IN
cord-341050-hnuogpqn	215	3	RdRp	RdRp	NNP
cord-341050-hnuogpqn	215	4	crystal	crystal	NN
cord-341050-hnuogpqn	215	5	structure	structure	NN
cord-341050-hnuogpqn	215	6	of	of	IN
cord-341050-hnuogpqn	215	7	WNV	WNV	NNP
cord-341050-hnuogpqn	215	8	and	and	CC
cord-341050-hnuogpqn	215	9	DENV3	DENV3	NNP
cord-341050-hnuogpqn	215	10	revealed	reveal	VBD
cord-341050-hnuogpqn	215	11	a	a	DT
cord-341050-hnuogpqn	215	12	cavity	cavity	NN
cord-341050-hnuogpqn	215	13	that	that	WDT
cord-341050-hnuogpqn	215	14	plays	play	VBZ
cord-341050-hnuogpqn	215	15	a	a	DT
cord-341050-hnuogpqn	215	16	critical	critical	JJ
cord-341050-hnuogpqn	215	17	role	role	NN
cord-341050-hnuogpqn	215	18	in	in	IN
cord-341050-hnuogpqn	215	19	viral	viral	JJ
cord-341050-hnuogpqn	215	20	replication	replication	NN
cord-341050-hnuogpqn	215	21	,	,	,
cord-341050-hnuogpqn	215	22	suggesting	suggest	VBG
cord-341050-hnuogpqn	215	23	a	a	DT
cord-341050-hnuogpqn	215	24	potential	potential	JJ
cord-341050-hnuogpqn	215	25	target	target	NN
cord-341050-hnuogpqn	215	26	for	for	IN
cord-341050-hnuogpqn	215	27	screening	screening	NN
cord-341050-hnuogpqn	215	28	of	of	IN
cord-341050-hnuogpqn	215	29	structurebased	structurebase	VBN
cord-341050-hnuogpqn	215	30	allosteric	allosteric	JJ
cord-341050-hnuogpqn	215	31	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	215	32	[	[	-LRB-
cord-341050-hnuogpqn	215	33	55	55	CD
cord-341050-hnuogpqn	215	34	,	,	,
cord-341050-hnuogpqn	215	35	283	283	CD
cord-341050-hnuogpqn	215	36	]	]	-RRB-
cord-341050-hnuogpqn	215	37	.	.	.
cord-341050-hnuogpqn	216	1	N	n	CD
cord-341050-hnuogpqn	216	2	-	-	HYPH
cord-341050-hnuogpqn	216	3	sulfonylanthranilic	sulfonylanthranilic	JJ
cord-341050-hnuogpqn	216	4	acids	acid	NNS
cord-341050-hnuogpqn	216	5	derivatives	derivative	NNS
cord-341050-hnuogpqn	216	6	identifi	identifi	NNP
cord-341050-hnuogpqn	216	7	ed	ed	NN
cord-341050-hnuogpqn	216	8	by	by	IN
cord-341050-hnuogpqn	216	9	high	high	JJ
cord-341050-hnuogpqn	216	10	-	-	HYPH
cord-341050-hnuogpqn	216	11	throughput	throughput	NN
cord-341050-hnuogpqn	216	12	screening	screening	NN
cord-341050-hnuogpqn	216	13	are	be	VBP
cord-341050-hnuogpqn	216	14	examples	example	NNS
cord-341050-hnuogpqn	216	15	of	of	IN
cord-341050-hnuogpqn	216	16	allosteric	allosteric	JJ
cord-341050-hnuogpqn	216	17	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	216	18	of	of	IN
cord-341050-hnuogpqn	216	19	RdRp	RdRp	NNP
cord-341050-hnuogpqn	216	20	activity	activity	NN
cord-341050-hnuogpqn	216	21	of	of	IN
cord-341050-hnuogpqn	216	22	DENV	DENV	NNP
cord-341050-hnuogpqn	216	23	[	[	-LRB-
cord-341050-hnuogpqn	216	24	284	284	CD
cord-341050-hnuogpqn	216	25	]	]	-RRB-
cord-341050-hnuogpqn	216	26	.	.	.
cord-341050-hnuogpqn	217	1	However	however	RB
cord-341050-hnuogpqn	217	2	,	,	,
cord-341050-hnuogpqn	217	3	these	these	DT
cord-341050-hnuogpqn	217	4	compound	compound	NN
cord-341050-hnuogpqn	217	5	were	be	VBD
cord-341050-hnuogpqn	217	6	specifi	specifi	VBN
cord-341050-hnuogpqn	217	7	c	c	NN
cord-341050-hnuogpqn	217	8	to	to	IN
cord-341050-hnuogpqn	217	9	DENV	DENV	NNP
cord-341050-hnuogpqn	217	10	and	and	CC
cord-341050-hnuogpqn	217	11	did	do	VBD
cord-341050-hnuogpqn	217	12	not	not	RB
cord-341050-hnuogpqn	217	13	show	show	VB
cord-341050-hnuogpqn	217	14	any	any	DT
cord-341050-hnuogpqn	217	15	activity	activity	NN
cord-341050-hnuogpqn	217	16	against	against	IN
cord-341050-hnuogpqn	217	17	WNV	WNV	NNP
cord-341050-hnuogpqn	217	18	RdRp	RdRp	NNP
cord-341050-hnuogpqn	217	19	.	.	.
cord-341050-hnuogpqn	218	1	A	a	DT
cord-341050-hnuogpqn	218	2	recent	recent	JJ
cord-341050-hnuogpqn	218	3	study	study	NN
cord-341050-hnuogpqn	218	4	demonstrated	demonstrate	VBD
cord-341050-hnuogpqn	218	5	that	that	IN
cord-341050-hnuogpqn	218	6	a	a	DT
cord-341050-hnuogpqn	218	7	conformational	conformational	JJ
cord-341050-hnuogpqn	218	8	change	change	NN
cord-341050-hnuogpqn	218	9	occurred	occur	VBD
cord-341050-hnuogpqn	218	10	in	in	IN
cord-341050-hnuogpqn	218	11	DENV-3	denv-3	NN
cord-341050-hnuogpqn	218	12	polymerase	polymerase	NN
cord-341050-hnuogpqn	218	13	after	after	IN
cord-341050-hnuogpqn	218	14	binding	bind	VBG
cord-341050-hnuogpqn	218	15	with	with	IN
cord-341050-hnuogpqn	218	16	an	an	DT
cord-341050-hnuogpqn	218	17	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	218	18	[	[	-LRB-
cord-341050-hnuogpqn	218	19	285	285	CD
cord-341050-hnuogpqn	218	20	]	]	-RRB-
cord-341050-hnuogpqn	218	21	.	.	.
cord-341050-hnuogpqn	219	1	However	however	RB
cord-341050-hnuogpqn	219	2	,	,	,
cord-341050-hnuogpqn	219	3	a	a	DT
cord-341050-hnuogpqn	219	4	similar	similar	JJ
cord-341050-hnuogpqn	219	5	antiviral	antiviral	JJ
cord-341050-hnuogpqn	219	6	activity	activity	NN
cord-341050-hnuogpqn	219	7	of	of	IN
cord-341050-hnuogpqn	219	8	NNI	NNI	NNP
cord-341050-hnuogpqn	219	9	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	219	10	targeting	target	VBG
cord-341050-hnuogpqn	219	11	polymerase	polymerase	NN
cord-341050-hnuogpqn	219	12	of	of	IN
cord-341050-hnuogpqn	219	13	WNV	WNV	NNP
cord-341050-hnuogpqn	219	14	has	have	VBZ
cord-341050-hnuogpqn	219	15	not	not	RB
cord-341050-hnuogpqn	219	16	been	be	VBN
cord-341050-hnuogpqn	219	17	reported	report	VBN
cord-341050-hnuogpqn	219	18	yet	yet	RB
cord-341050-hnuogpqn	219	19	.	.	.
cord-341050-hnuogpqn	220	1	Messenger	Messenger	NNP
cord-341050-hnuogpqn	220	2	RNA	RNA	NNP
cord-341050-hnuogpqn	220	3	(	(	-LRB-
cord-341050-hnuogpqn	220	4	mRNA	mrna	NN
cord-341050-hnuogpqn	220	5	)	)	-RRB-
cord-341050-hnuogpqn	220	6	of	of	IN
cord-341050-hnuogpqn	220	7	WNV	WNV	NNP
cord-341050-hnuogpqn	220	8	possesses	possess	VBZ
cord-341050-hnuogpqn	220	9	a	a	DT
cord-341050-hnuogpqn	220	10	5′	5′	CD
cord-341050-hnuogpqn	220	11	cap	cap	NN
cord-341050-hnuogpqn	220	12	that	that	WDT
cord-341050-hnuogpqn	220	13	plays	play	VBZ
cord-341050-hnuogpqn	220	14	important	important	JJ
cord-341050-hnuogpqn	220	15	roles	role	NNS
cord-341050-hnuogpqn	220	16	in	in	IN
cord-341050-hnuogpqn	220	17	stability	stability	NN
cord-341050-hnuogpqn	220	18	of	of	IN
cord-341050-hnuogpqn	220	19	mRNA	mrna	NN
cord-341050-hnuogpqn	220	20	and	and	CC
cord-341050-hnuogpqn	220	21	its	-PRON-	PRP$
cord-341050-hnuogpqn	220	22	translation	translation	NN
cord-341050-hnuogpqn	220	23	.	.	.
cord-341050-hnuogpqn	221	1	The	the	DT
cord-341050-hnuogpqn	221	2	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	221	3	(	(	-LRB-
cord-341050-hnuogpqn	221	4	MTase	MTase	NNP
cord-341050-hnuogpqn	221	5	)	)	-RRB-
cord-341050-hnuogpqn	221	6	activity	activity	NN
cord-341050-hnuogpqn	221	7	of	of	IN
cord-341050-hnuogpqn	221	8	the	the	DT
cord-341050-hnuogpqn	221	9	N	n	CD
cord-341050-hnuogpqn	221	10	-	-	HYPH
cord-341050-hnuogpqn	221	11	terminal	terminal	NN
cord-341050-hnuogpqn	221	12	domain	domain	NN
cord-341050-hnuogpqn	221	13	of	of	IN
cord-341050-hnuogpqn	221	14	NS5	NS5	NNP
cord-341050-hnuogpqn	221	15	is	be	VBZ
cord-341050-hnuogpqn	221	16	responsible	responsible	JJ
cord-341050-hnuogpqn	221	17	for	for	IN
cord-341050-hnuogpqn	221	18	N-7	N-7	NNP
cord-341050-hnuogpqn	221	19	and	and	CC
cord-341050-hnuogpqn	221	20	2′	2′	NNP
cord-341050-hnuogpqn	221	21	O	o	NN
cord-341050-hnuogpqn	221	22	-	-	HYPH
cord-341050-hnuogpqn	221	23	methylation	methylation	NN
cord-341050-hnuogpqn	221	24	of	of	IN
cord-341050-hnuogpqn	221	25	the	the	DT
cord-341050-hnuogpqn	221	26	viral	viral	JJ
cord-341050-hnuogpqn	221	27	RNA	RNA	NNP
cord-341050-hnuogpqn	221	28	cap	cap	NN
cord-341050-hnuogpqn	221	29	[	[	-LRB-
cord-341050-hnuogpqn	221	30	64	64	CD
cord-341050-hnuogpqn	221	31	,	,	,
cord-341050-hnuogpqn	221	32	286	286	CD
cord-341050-hnuogpqn	221	33	]	]	-RRB-
cord-341050-hnuogpqn	221	34	[	[	-LRB-
cord-341050-hnuogpqn	221	35	287	287	CD
cord-341050-hnuogpqn	221	36	]	]	-RRB-
cord-341050-hnuogpqn	221	37	.	.	.
cord-341050-hnuogpqn	222	1	In	in	IN
cord-341050-hnuogpqn	222	2	addition	addition	NN
cord-341050-hnuogpqn	222	3	,	,	,
cord-341050-hnuogpqn	222	4	MTase	MTase	NNP
cord-341050-hnuogpqn	222	5	activity	activity	NN
cord-341050-hnuogpqn	222	6	is	be	VBZ
cord-341050-hnuogpqn	222	7	also	also	RB
cord-341050-hnuogpqn	222	8	responsible	responsible	JJ
cord-341050-hnuogpqn	222	9	for	for	IN
cord-341050-hnuogpqn	222	10	evading	evade	VBG
cord-341050-hnuogpqn	222	11	host	host	NN
cord-341050-hnuogpqn	222	12	's	's	POS
cord-341050-hnuogpqn	222	13	antiviral	antiviral	JJ
cord-341050-hnuogpqn	222	14	interferon	interferon	NN
cord-341050-hnuogpqn	222	15	response	response	NN
cord-341050-hnuogpqn	222	16	and	and	CC
cord-341050-hnuogpqn	222	17	plays	play	VBZ
cord-341050-hnuogpqn	222	18	an	an	DT
cord-341050-hnuogpqn	222	19	important	important	JJ
cord-341050-hnuogpqn	222	20	role	role	NN
cord-341050-hnuogpqn	222	21	in	in	IN
cord-341050-hnuogpqn	222	22	WNV	WNV	NNP
cord-341050-hnuogpqn	222	23	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	222	24	[	[	-LRB-
cord-341050-hnuogpqn	222	25	288	288	CD
cord-341050-hnuogpqn	222	26	]	]	-RRB-
cord-341050-hnuogpqn	222	27	.	.	.
cord-341050-hnuogpqn	223	1	Several	several	JJ
cord-341050-hnuogpqn	223	2	structural	structural	JJ
cord-341050-hnuogpqn	223	3	and	and	CC
cord-341050-hnuogpqn	223	4	functional	functional	JJ
cord-341050-hnuogpqn	223	5	studies	study	NNS
cord-341050-hnuogpqn	223	6	along	along	IN
cord-341050-hnuogpqn	223	7	with	with	IN
cord-341050-hnuogpqn	223	8	identifi	identifi	NNP
cord-341050-hnuogpqn	223	9	cation	cation	NN
cord-341050-hnuogpqn	223	10	of	of	IN
cord-341050-hnuogpqn	223	11	several	several	JJ
cord-341050-hnuogpqn	223	12	potential	potential	JJ
cord-341050-hnuogpqn	223	13	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	223	14	suggest	suggest	VBP
cord-341050-hnuogpqn	223	15	that	that	IN
cord-341050-hnuogpqn	223	16	targeting	target	VBG
cord-341050-hnuogpqn	223	17	MTase	MTase	NNP
cord-341050-hnuogpqn	223	18	represents	represent	VBZ
cord-341050-hnuogpqn	223	19	a	a	DT
cord-341050-hnuogpqn	223	20	novel	novel	JJ
cord-341050-hnuogpqn	223	21	approach	approach	NN
cord-341050-hnuogpqn	223	22	for	for	IN
cord-341050-hnuogpqn	223	23	the	the	DT
cord-341050-hnuogpqn	223	24	development	development	NN
cord-341050-hnuogpqn	223	25	of	of	IN
cord-341050-hnuogpqn	223	26	novel	novel	JJ
cord-341050-hnuogpqn	223	27	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	223	28	against	against	IN
cord-341050-hnuogpqn	223	29	WNV	WNV	NNP
cord-341050-hnuogpqn	223	30	and	and	CC
cord-341050-hnuogpqn	223	31	other	other	JJ
cord-341050-hnuogpqn	223	32	fl	fl	NNP
cord-341050-hnuogpqn	223	33	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	223	34	[	[	-LRB-
cord-341050-hnuogpqn	223	35	289	289	CD
cord-341050-hnuogpqn	223	36	-294	-294	NN
cord-341050-hnuogpqn	223	37	]	]	-RRB-
cord-341050-hnuogpqn	223	38	.	.	.
cord-341050-hnuogpqn	224	1	Flaviviruses	Flaviviruses	NNP
cord-341050-hnuogpqn	224	2	MTase	MTase	NNP
cord-341050-hnuogpqn	224	3	catalyzes	catalyze	VBZ
cord-341050-hnuogpqn	224	4	sequential	sequential	JJ
cord-341050-hnuogpqn	224	5	methylations	methylation	NNS
cord-341050-hnuogpqn	224	6	of	of	IN
cord-341050-hnuogpqn	224	7	the	the	DT
cord-341050-hnuogpqn	224	8	viral	viral	JJ
cord-341050-hnuogpqn	224	9	RNA	RNA	NNP
cord-341050-hnuogpqn	224	10	cap	cap	NN
cord-341050-hnuogpqn	224	11	using	use	VBG
cord-341050-hnuogpqn	224	12	S	s	NN
cord-341050-hnuogpqn	224	13	-	-	HYPH
cord-341050-hnuogpqn	224	14	adenosyl	adenosyl	NN
cord-341050-hnuogpqn	224	15	-	-	HYPH
cord-341050-hnuogpqn	224	16	L	l	NN
cord-341050-hnuogpqn	224	17	-methionine	-methionine	NN
cord-341050-hnuogpqn	224	18	(	(	-LRB-
cord-341050-hnuogpqn	224	19	SAM	SAM	NNP
cord-341050-hnuogpqn	224	20	)	)	-RRB-
cord-341050-hnuogpqn	224	21	as	as	IN
cord-341050-hnuogpqn	224	22	the	the	DT
cord-341050-hnuogpqn	224	23	methyl	methyl	NN
cord-341050-hnuogpqn	224	24	donor	donor	NN
cord-341050-hnuogpqn	224	25	and	and	CC
cord-341050-hnuogpqn	224	26	contains	contain	VBZ
cord-341050-hnuogpqn	224	27	a	a	DT
cord-341050-hnuogpqn	224	28	single	single	JJ
cord-341050-hnuogpqn	224	29	binding	binding	NN
cord-341050-hnuogpqn	224	30	site	site	NN
cord-341050-hnuogpqn	224	31	for	for	IN
cord-341050-hnuogpqn	224	32	SAM	SAM	NNP
cord-341050-hnuogpqn	224	33	in	in	IN
cord-341050-hnuogpqn	224	34	its	-PRON-	PRP$
cord-341050-hnuogpqn	224	35	crystal	crystal	NN
cord-341050-hnuogpqn	224	36	structure	structure	NN
cord-341050-hnuogpqn	224	37	[	[	-LRB-
cord-341050-hnuogpqn	224	38	289	289	CD
cord-341050-hnuogpqn	224	39	,	,	,
cord-341050-hnuogpqn	224	40	294	294	CD
cord-341050-hnuogpqn	224	41	]	]	-RRB-
cord-341050-hnuogpqn	224	42	.	.	.
cord-341050-hnuogpqn	225	1	In	in	IN
cord-341050-hnuogpqn	225	2	addition	addition	NN
cord-341050-hnuogpqn	225	3	to	to	IN
cord-341050-hnuogpqn	225	4	MTase	MTase	NNP
cord-341050-hnuogpqn	225	5	activity	activity	NN
cord-341050-hnuogpqn	225	6	,	,	,
cord-341050-hnuogpqn	225	7	binding	bind	VBG
cord-341050-hnuogpqn	225	8	of	of	IN
cord-341050-hnuogpqn	225	9	GTP	GTP	NNP
cord-341050-hnuogpqn	225	10	has	have	VBZ
cord-341050-hnuogpqn	225	11	been	be	VBN
cord-341050-hnuogpqn	225	12	shown	show	VBN
cord-341050-hnuogpqn	225	13	in	in	IN
cord-341050-hnuogpqn	225	14	MTase	MTase	NNP
cord-341050-hnuogpqn	225	15	domain	domain	NN
cord-341050-hnuogpqn	225	16	of	of	IN
cord-341050-hnuogpqn	225	17	several	several	JJ
cord-341050-hnuogpqn	225	18	members	member	NNS
cord-341050-hnuogpqn	225	19	of	of	IN
cord-341050-hnuogpqn	225	20	fl	fl	NNP
cord-341050-hnuogpqn	225	21	avivirus	avivirus	NNP
cord-341050-hnuogpqn	225	22	[	[	-LRB-
cord-341050-hnuogpqn	225	23	295	295	CD
cord-341050-hnuogpqn	225	24	]	]	-RRB-
cord-341050-hnuogpqn	225	25	.	.	.
cord-341050-hnuogpqn	226	1	Several	several	JJ
cord-341050-hnuogpqn	226	2	assays	assay	NNS
cord-341050-hnuogpqn	226	3	have	have	VBP
cord-341050-hnuogpqn	226	4	been	be	VBN
cord-341050-hnuogpqn	226	5	developed	develop	VBN
cord-341050-hnuogpqn	226	6	for	for	IN
cord-341050-hnuogpqn	226	7	high	high	JJ
cord-341050-hnuogpqn	226	8	-	-	HYPH
cord-341050-hnuogpqn	226	9	throughput	throughput	NN
cord-341050-hnuogpqn	226	10	screening	screening	NN
cord-341050-hnuogpqn	226	11	of	of	IN
cord-341050-hnuogpqn	226	12	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	226	13	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	226	14	by	by	IN
cord-341050-hnuogpqn	226	15	structural	structural	NN
cord-341050-hnuogpqn	226	16	-	-	HYPH
cord-341050-hnuogpqn	226	17	based	base	VBN
cord-341050-hnuogpqn	226	18	and	and	CC
cord-341050-hnuogpqn	226	19	ligand	ligand	NN
cord-341050-hnuogpqn	226	20	-	-	HYPH
cord-341050-hnuogpqn	226	21	based	base	VBN
cord-341050-hnuogpqn	226	22	methods	method	NNS
cord-341050-hnuogpqn	226	23	[	[	-LRB-
cord-341050-hnuogpqn	226	24	296	296	CD
cord-341050-hnuogpqn	226	25	,	,	,
cord-341050-hnuogpqn	226	26	297	297	CD
cord-341050-hnuogpqn	226	27	]	]	-RRB-
cord-341050-hnuogpqn	226	28	.	.	.
cord-341050-hnuogpqn	227	1	Rational	rational	JJ
cord-341050-hnuogpqn	227	2	design	design	NN
cord-341050-hnuogpqn	227	3	of	of	IN
cord-341050-hnuogpqn	227	4	SAM	SAM	NNP
cord-341050-hnuogpqn	227	5	analogs	analogs	NNP
cord-341050-hnuogpqn	227	6	has	have	VBZ
cord-341050-hnuogpqn	227	7	identifi	identifi	VBN
cord-341050-hnuogpqn	227	8	ed	ed	NNP
cord-341050-hnuogpqn	227	9	several	several	JJ
cord-341050-hnuogpqn	227	10	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	227	11	targeting	target	VBG
cord-341050-hnuogpqn	227	12	MTase	MTase	NNP
cord-341050-hnuogpqn	227	13	activity	activity	NN
cord-341050-hnuogpqn	227	14	of	of	IN
cord-341050-hnuogpqn	227	15	DENV	DENV	NNP
cord-341050-hnuogpqn	227	16	and	and	CC
cord-341050-hnuogpqn	227	17	WNV	WNV	NNP
cord-341050-hnuogpqn	227	18	[	[	-LRB-
cord-341050-hnuogpqn	227	19	34	34	CD
cord-341050-hnuogpqn	227	20	,	,	,
cord-341050-hnuogpqn	227	21	298	298	CD
cord-341050-hnuogpqn	227	22	]	]	-RRB-
cord-341050-hnuogpqn	227	23	.	.	.
cord-341050-hnuogpqn	228	1	Nonspecifi	nonspecifi	NN
cord-341050-hnuogpqn	228	2	c	c	NN
cord-341050-hnuogpqn	228	3	inhibition	inhibition	NN
cord-341050-hnuogpqn	228	4	of	of	IN
cord-341050-hnuogpqn	228	5	host	host	NN
cord-341050-hnuogpqn	228	6	MTase	MTase	NNP
cord-341050-hnuogpqn	228	7	is	be	VBZ
cord-341050-hnuogpqn	228	8	one	one	CD
cord-341050-hnuogpqn	228	9	of	of	IN
cord-341050-hnuogpqn	228	10	the	the	DT
cord-341050-hnuogpqn	228	11	potential	potential	JJ
cord-341050-hnuogpqn	228	12	drawbacks	drawback	NNS
cord-341050-hnuogpqn	228	13	of	of	IN
cord-341050-hnuogpqn	228	14	SAM	SAM	NNP
cord-341050-hnuogpqn	228	15	analogs	analog	NNS
cord-341050-hnuogpqn	228	16	.	.	.
cord-341050-hnuogpqn	229	1	A	a	DT
cord-341050-hnuogpqn	229	2	specifi	specifi	NN
cord-341050-hnuogpqn	229	3	c	c	NN
cord-341050-hnuogpqn	229	4	inhibition	inhibition	NN
cord-341050-hnuogpqn	229	5	of	of	IN
cord-341050-hnuogpqn	229	6	fl	fl	NNP
cord-341050-hnuogpqn	229	7	aviviral	aviviral	NNP
cord-341050-hnuogpqn	229	8	,	,	,
cord-341050-hnuogpqn	229	9	but	but	CC
cord-341050-hnuogpqn	229	10	not	not	RB
cord-341050-hnuogpqn	229	11	host	host	VB
cord-341050-hnuogpqn	229	12	,	,	,
cord-341050-hnuogpqn	229	13	MTase	MTase	NNP
cord-341050-hnuogpqn	229	14	can	can	MD
cord-341050-hnuogpqn	229	15	be	be	VB
cord-341050-hnuogpqn	229	16	achieved	achieve	VBN
cord-341050-hnuogpqn	229	17	by	by	IN
cord-341050-hnuogpqn	229	18	targeting	target	VBG
cord-341050-hnuogpqn	229	19	a	a	DT
cord-341050-hnuogpqn	229	20	pocket	pocket	NN
cord-341050-hnuogpqn	229	21	near	near	IN
cord-341050-hnuogpqn	229	22	the	the	DT
cord-341050-hnuogpqn	229	23	SAM	SAM	NNP
cord-341050-hnuogpqn	229	24	-	-	HYPH
cord-341050-hnuogpqn	229	25	binding	bind	VBG
cord-341050-hnuogpqn	229	26	site	site	NN
cord-341050-hnuogpqn	229	27	[	[	-LRB-
cord-341050-hnuogpqn	229	28	290	290	CD
cord-341050-hnuogpqn	229	29	,	,	,
cord-341050-hnuogpqn	229	30	298	298	CD
cord-341050-hnuogpqn	229	31	]	]	-RRB-
cord-341050-hnuogpqn	229	32	.	.	.
cord-341050-hnuogpqn	230	1	Two	two	CD
cord-341050-hnuogpqn	230	2	nucleoside	nucleoside	NN
cord-341050-hnuogpqn	230	3	analogs	analog	NNS
cord-341050-hnuogpqn	230	4	were	be	VBD
cord-341050-hnuogpqn	230	5	identifi	identifi	VBN
cord-341050-hnuogpqn	230	6	ed	ed	NN
cord-341050-hnuogpqn	230	7	that	that	WDT
cord-341050-hnuogpqn	230	8	potently	potently	RB
cord-341050-hnuogpqn	230	9	inhibited	inhibit	VBD
cord-341050-hnuogpqn	230	10	the	the	DT
cord-341050-hnuogpqn	230	11	MTase	MTase	NNP
cord-341050-hnuogpqn	230	12	of	of	IN
cord-341050-hnuogpqn	230	13	WNV	WNV	NNP
cord-341050-hnuogpqn	230	14	without	without	IN
cord-341050-hnuogpqn	230	15	inhibiting	inhibit	VBG
cord-341050-hnuogpqn	230	16	human	human	JJ
cord-341050-hnuogpqn	230	17	MTase	mtase	NN
cord-341050-hnuogpqn	230	18	.	.	.
cord-341050-hnuogpqn	231	1	One	one	CD
cord-341050-hnuogpqn	231	2	of	of	IN
cord-341050-hnuogpqn	231	3	these	these	DT
cord-341050-hnuogpqn	231	4	compounds	compound	NNS
cord-341050-hnuogpqn	231	5	(	(	-LRB-
cord-341050-hnuogpqn	231	6	GRL-003	grl-003	NN
cord-341050-hnuogpqn	231	7	)	)	-RRB-
cord-341050-hnuogpqn	231	8	showed	show	VBD
cord-341050-hnuogpqn	231	9	antiviral	antiviral	JJ
cord-341050-hnuogpqn	231	10	activity	activity	NN
cord-341050-hnuogpqn	231	11	against	against	IN
cord-341050-hnuogpqn	231	12	WNV	WNV	NNP
cord-341050-hnuogpqn	231	13	in	in	IN
cord-341050-hnuogpqn	231	14	cell	cell	NN
cord-341050-hnuogpqn	231	15	culture	culture	NN
cord-341050-hnuogpqn	231	16	[	[	-LRB-
cord-341050-hnuogpqn	231	17	299	299	CD
cord-341050-hnuogpqn	231	18	]	]	-RRB-
cord-341050-hnuogpqn	231	19	.	.	.
cord-341050-hnuogpqn	232	1	In	in	IN
cord-341050-hnuogpqn	232	2	addition	addition	NN
cord-341050-hnuogpqn	232	3	,	,	,
cord-341050-hnuogpqn	232	4	several	several	JJ
cord-341050-hnuogpqn	232	5	screening	screening	NN
cord-341050-hnuogpqn	232	6	studies	study	NNS
cord-341050-hnuogpqn	232	7	against	against	IN
cord-341050-hnuogpqn	232	8	YFV	YFV	NNP
cord-341050-hnuogpqn	232	9	and	and	CC
cord-341050-hnuogpqn	232	10	DENV	DENV	NNP
cord-341050-hnuogpqn	232	11	NS5	NS5	NNP
cord-341050-hnuogpqn	232	12	have	have	VBP
cord-341050-hnuogpqn	232	13	identifi	identifi	VBN
cord-341050-hnuogpqn	232	14	ed	ed	NNP
cord-341050-hnuogpqn	232	15	hits	hit	NNS
cord-341050-hnuogpqn	232	16	targeting	target	VBG
cord-341050-hnuogpqn	232	17	MTase	MTase	NNP
cord-341050-hnuogpqn	232	18	activity	activity	NN
cord-341050-hnuogpqn	232	19	,	,	,
cord-341050-hnuogpqn	232	20	some	some	DT
cord-341050-hnuogpqn	232	21	of	of	IN
cord-341050-hnuogpqn	232	22	which	which	WDT
cord-341050-hnuogpqn	232	23	showed	show	VBD
cord-341050-hnuogpqn	232	24	antiviral	antiviral	JJ
cord-341050-hnuogpqn	232	25	activity	activity	NN
cord-341050-hnuogpqn	232	26	against	against	IN
cord-341050-hnuogpqn	232	27	WNV	WNV	NNP
cord-341050-hnuogpqn	232	28	in	in	IN
cord-341050-hnuogpqn	232	29	cell	cell	NN
cord-341050-hnuogpqn	232	30	culture	culture	NN
cord-341050-hnuogpqn	232	31	[	[	-LRB-
cord-341050-hnuogpqn	232	32	204	204	CD
cord-341050-hnuogpqn	232	33	,	,	,
cord-341050-hnuogpqn	232	34	300	300	CD
cord-341050-hnuogpqn	232	35	,	,	,
cord-341050-hnuogpqn	232	36	301	301	CD
cord-341050-hnuogpqn	232	37	]	]	-RRB-
cord-341050-hnuogpqn	232	38	.	.	.
cord-341050-hnuogpqn	233	1	However	however	RB
cord-341050-hnuogpqn	233	2	,	,	,
cord-341050-hnuogpqn	233	3	an	an	DT
cord-341050-hnuogpqn	233	4	extensive	extensive	JJ
cord-341050-hnuogpqn	233	5	multistage	multistage	NN
cord-341050-hnuogpqn	233	6	molecular	molecular	JJ
cord-341050-hnuogpqn	233	7	docking	docking	NN
cord-341050-hnuogpqn	233	8	approach	approach	NN
cord-341050-hnuogpqn	233	9	to	to	TO
cord-341050-hnuogpqn	233	10	screen	screen	VB
cord-341050-hnuogpqn	233	11	a	a	DT
cord-341050-hnuogpqn	233	12	library	library	NN
cord-341050-hnuogpqn	233	13	of	of	IN
cord-341050-hnuogpqn	233	14	about	about	RB
cord-341050-hnuogpqn	233	15	5	5	CD
cord-341050-hnuogpqn	233	16	millions	million	NNS
cord-341050-hnuogpqn	233	17	of	of	IN
cord-341050-hnuogpqn	233	18	commercial	commercial	JJ
cord-341050-hnuogpqn	233	19	compounds	compound	NNS
cord-341050-hnuogpqn	233	20	against	against	IN
cord-341050-hnuogpqn	233	21	two	two	CD
cord-341050-hnuogpqn	233	22	active	active	JJ
cord-341050-hnuogpqn	233	23	sites	site	NNS
cord-341050-hnuogpqn	233	24	of	of	IN
cord-341050-hnuogpqn	233	25	DENV	DENV	NNP
cord-341050-hnuogpqn	233	26	MTase	MTase	NNP
cord-341050-hnuogpqn	233	27	/	/	SYM
cord-341050-hnuogpqn	233	28	GTase	GTase	NNP
cord-341050-hnuogpqn	233	29	failed	fail	VBD
cord-341050-hnuogpqn	233	30	to	to	TO
cord-341050-hnuogpqn	233	31	identify	identify	VB
cord-341050-hnuogpqn	233	32	any	any	DT
cord-341050-hnuogpqn	233	33	specifi	specifi	NN
cord-341050-hnuogpqn	233	34	c	c	NN
cord-341050-hnuogpqn	233	35	hits	hit	NNS
cord-341050-hnuogpqn	233	36	[	[	-LRB-
cord-341050-hnuogpqn	233	37	302	302	CD
cord-341050-hnuogpqn	233	38	]	]	-RRB-
cord-341050-hnuogpqn	233	39	.	.	.
cord-341050-hnuogpqn	234	1	Recently	recently	RB
cord-341050-hnuogpqn	234	2	,	,	,
cord-341050-hnuogpqn	234	3	5′-silylated	5′-silylated	CD
cord-341050-hnuogpqn	234	4	nucleoside	nucleoside	NN
cord-341050-hnuogpqn	234	5	scaffold	scaffold	NN
cord-341050-hnuogpqn	234	6	derived	derive	VBN
cord-341050-hnuogpqn	234	7	from	from	IN
cord-341050-hnuogpqn	234	8	3′-azidothymidine	3′-azidothymidine	NNP
cord-341050-hnuogpqn	234	9	(	(	-LRB-
cord-341050-hnuogpqn	234	10	AZT	AZT	NNP
cord-341050-hnuogpqn	234	11	)	)	-RRB-
cord-341050-hnuogpqn	234	12	demonstrated	demonstrate	VBD
cord-341050-hnuogpqn	234	13	antiviral	antiviral	JJ
cord-341050-hnuogpqn	234	14	activity	activity	NN
cord-341050-hnuogpqn	234	15	against	against	IN
cord-341050-hnuogpqn	234	16	WNV	WNV	NNP
cord-341050-hnuogpqn	234	17	and	and	CC
cord-341050-hnuogpqn	234	18	DENV	DENV	NNP
cord-341050-hnuogpqn	234	19	,	,	,
cord-341050-hnuogpqn	234	20	which	which	WDT
cord-341050-hnuogpqn	234	21	binds	bind	VBZ
cord-341050-hnuogpqn	234	22	MTase	MTase	NNP
cord-341050-hnuogpqn	234	23	[	[	-LRB-
cord-341050-hnuogpqn	234	24	303	303	CD
cord-341050-hnuogpqn	234	25	]	]	-RRB-
cord-341050-hnuogpqn	234	26	.	.	.
cord-341050-hnuogpqn	235	1	Several	several	JJ
cord-341050-hnuogpqn	235	2	potential	potential	JJ
cord-341050-hnuogpqn	235	3	tools	tool	NNS
cord-341050-hnuogpqn	235	4	,	,	,
cord-341050-hnuogpqn	235	5	including	include	VBG
cord-341050-hnuogpqn	235	6	rational	rational	JJ
cord-341050-hnuogpqn	235	7	design	design	NN
cord-341050-hnuogpqn	235	8	and	and	CC
cord-341050-hnuogpqn	235	9	phase	phase	NN
cord-341050-hnuogpqn	235	10	display	display	NN
cord-341050-hnuogpqn	235	11	library	library	NN
cord-341050-hnuogpqn	235	12	,	,	,
cord-341050-hnuogpqn	235	13	have	have	VBP
cord-341050-hnuogpqn	235	14	been	be	VBN
cord-341050-hnuogpqn	235	15	developed	develop	VBN
cord-341050-hnuogpqn	235	16	for	for	IN
cord-341050-hnuogpqn	235	17	high	high	JJ
cord-341050-hnuogpqn	235	18	-	-	HYPH
cord-341050-hnuogpqn	235	19	throughput	throughput	NN
cord-341050-hnuogpqn	235	20	screening	screening	NN
cord-341050-hnuogpqn	235	21	of	of	IN
cord-341050-hnuogpqn	235	22	specifi	specifi	NNP
cord-341050-hnuogpqn	235	23	c	c	NNP
cord-341050-hnuogpqn	235	24	antiviral	antiviral	JJ
cord-341050-hnuogpqn	235	25	peptides	peptide	NNS
cord-341050-hnuogpqn	235	26	[	[	-LRB-
cord-341050-hnuogpqn	235	27	304	304	CD
cord-341050-hnuogpqn	235	28	,	,	,
cord-341050-hnuogpqn	235	29	305	305	CD
cord-341050-hnuogpqn	235	30	]	]	-RRB-
cord-341050-hnuogpqn	235	31	.	.	.
cord-341050-hnuogpqn	236	1	Enfuvirtide	Enfuvirtide	NNP
cord-341050-hnuogpqn	236	2	,	,	,
cord-341050-hnuogpqn	236	3	a	a	DT
cord-341050-hnuogpqn	236	4	36-aminoacid	36-aminoacid	CD
cord-341050-hnuogpqn	236	5	peptide	peptide	NN
cord-341050-hnuogpqn	236	6	based	base	VBN
cord-341050-hnuogpqn	236	7	on	on	IN
cord-341050-hnuogpqn	236	8	the	the	DT
cord-341050-hnuogpqn	236	9	stem	stem	NN
cord-341050-hnuogpqn	236	10	region	region	NN
cord-341050-hnuogpqn	236	11	of	of	IN
cord-341050-hnuogpqn	236	12	the	the	DT
cord-341050-hnuogpqn	236	13	HIV	HIV	NNP
cord-341050-hnuogpqn	236	14	gp41	gp41	NNP
cord-341050-hnuogpqn	236	15	,	,	,
cord-341050-hnuogpqn	236	16	exemplifi	exemplifi	NNP
cord-341050-hnuogpqn	236	17	es	es	NNP
cord-341050-hnuogpqn	236	18	an	an	DT
cord-341050-hnuogpqn	236	19	effi	effi	NNP
cord-341050-hnuogpqn	236	20	cient	cient	NNP
cord-341050-hnuogpqn	236	21	antiviral	antiviral	JJ
cord-341050-hnuogpqn	236	22	peptide	peptide	NN
cord-341050-hnuogpqn	236	23	currently	currently	RB
cord-341050-hnuogpqn	236	24	in	in	IN
cord-341050-hnuogpqn	236	25	clinical	clinical	JJ
cord-341050-hnuogpqn	236	26	use	use	NN
cord-341050-hnuogpqn	236	27	[	[	-LRB-
cord-341050-hnuogpqn	236	28	306	306	CD
cord-341050-hnuogpqn	236	29	]	]	-RRB-
cord-341050-hnuogpqn	236	30	.	.	.
cord-341050-hnuogpqn	237	1	Thus	thus	RB
cord-341050-hnuogpqn	237	2	,	,	,
cord-341050-hnuogpqn	237	3	antiviral	antiviral	JJ
cord-341050-hnuogpqn	237	4	peptides	peptide	NNS
cord-341050-hnuogpqn	237	5	may	may	MD
cord-341050-hnuogpqn	237	6	serve	serve	VB
cord-341050-hnuogpqn	237	7	as	as	IN
cord-341050-hnuogpqn	237	8	a	a	DT
cord-341050-hnuogpqn	237	9	novel	novel	JJ
cord-341050-hnuogpqn	237	10	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	237	11	measure	measure	NN
cord-341050-hnuogpqn	237	12	against	against	IN
cord-341050-hnuogpqn	237	13	WNV	WNV	NNP
cord-341050-hnuogpqn	237	14	.	.	.
cord-341050-hnuogpqn	238	1	Several	several	JJ
cord-341050-hnuogpqn	238	2	antiviral	antiviral	JJ
cord-341050-hnuogpqn	238	3	peptides	peptide	NNS
cord-341050-hnuogpqn	238	4	targeting	target	VBG
cord-341050-hnuogpqn	238	5	both	both	DT
cord-341050-hnuogpqn	238	6	structural	structural	JJ
cord-341050-hnuogpqn	238	7	and	and	CC
cord-341050-hnuogpqn	238	8	non	non	JJ
cord-341050-hnuogpqn	238	9	-	-	JJ
cord-341050-hnuogpqn	238	10	structural	structural	JJ
cord-341050-hnuogpqn	238	11	protein	protein	NN
cord-341050-hnuogpqn	238	12	of	of	IN
cord-341050-hnuogpqn	238	13	WNV	WNV	NNP
cord-341050-hnuogpqn	238	14	and	and	CC
cord-341050-hnuogpqn	238	15	other	other	JJ
cord-341050-hnuogpqn	238	16	fl	fl	NNP
cord-341050-hnuogpqn	238	17	avivirus	avivirus	NNP
cord-341050-hnuogpqn	238	18	have	have	VBP
cord-341050-hnuogpqn	238	19	been	be	VBN
cord-341050-hnuogpqn	238	20	identifi	identifi	VBN
cord-341050-hnuogpqn	238	21	ed	ed	NN
cord-341050-hnuogpqn	238	22	.	.	.
cord-341050-hnuogpqn	239	1	Targeting	target	VBG
cord-341050-hnuogpqn	239	2	WNV	WNV	NNP
cord-341050-hnuogpqn	239	3	E	e	NN
cord-341050-hnuogpqn	239	4	protein	protein	NN
cord-341050-hnuogpqn	239	5	by	by	IN
cord-341050-hnuogpqn	239	6	antiviral	antiviral	JJ
cord-341050-hnuogpqn	239	7	peptides	peptide	NNS
cord-341050-hnuogpqn	239	8	is	be	VBZ
cord-341050-hnuogpqn	239	9	a	a	DT
cord-341050-hnuogpqn	239	10	potential	potential	JJ
cord-341050-hnuogpqn	239	11	strategy	strategy	NN
cord-341050-hnuogpqn	239	12	that	that	WDT
cord-341050-hnuogpqn	239	13	blocks	block	VBZ
cord-341050-hnuogpqn	239	14	virus	virus	NN
cord-341050-hnuogpqn	239	15	attachment	attachment	NN
cord-341050-hnuogpqn	239	16	and	and	CC
cord-341050-hnuogpqn	239	17	entry	entry	NN
cord-341050-hnuogpqn	239	18	into	into	IN
cord-341050-hnuogpqn	239	19	the	the	DT
cord-341050-hnuogpqn	239	20	host	host	NN
cord-341050-hnuogpqn	239	21	cells	cell	NNS
cord-341050-hnuogpqn	239	22	.	.	.
cord-341050-hnuogpqn	240	1	Several	several	JJ
cord-341050-hnuogpqn	240	2	short	short	JJ
cord-341050-hnuogpqn	240	3	antiviral	antiviral	JJ
cord-341050-hnuogpqn	240	4	peptides	peptide	NNS
cord-341050-hnuogpqn	240	5	(	(	-LRB-
cord-341050-hnuogpqn	240	6	13	13	CD
cord-341050-hnuogpqn	240	7	-	-	SYM
cord-341050-hnuogpqn	240	8	16	16	CD
cord-341050-hnuogpqn	240	9	amino	amino	NN
cord-341050-hnuogpqn	240	10	acid	acid	NN
cord-341050-hnuogpqn	240	11	residuals	residual	NNS
cord-341050-hnuogpqn	240	12	)	)	-RRB-
cord-341050-hnuogpqn	240	13	that	that	WDT
cord-341050-hnuogpqn	240	14	bind	bind	VBP
cord-341050-hnuogpqn	240	15	to	to	IN
cord-341050-hnuogpqn	240	16	WNV	WNV	NNP
cord-341050-hnuogpqn	240	17	E	E	NNP
cord-341050-hnuogpqn	240	18	protein	protein	NN
cord-341050-hnuogpqn	240	19	have	have	VBP
cord-341050-hnuogpqn	240	20	been	be	VBN
cord-341050-hnuogpqn	240	21	identifi	identifi	VBN
cord-341050-hnuogpqn	240	22	ed	ed	NN
cord-341050-hnuogpqn	240	23	by	by	IN
cord-341050-hnuogpqn	240	24	screening	screening	NN
cord-341050-hnuogpqn	240	25	of	of	IN
cord-341050-hnuogpqn	240	26	a	a	DT
cord-341050-hnuogpqn	240	27	murine	murine	JJ
cord-341050-hnuogpqn	240	28	brain	brain	NN
cord-341050-hnuogpqn	240	29	cDNA	cdna	NN
cord-341050-hnuogpqn	240	30	phage	phage	NN
cord-341050-hnuogpqn	240	31	display	display	NN
cord-341050-hnuogpqn	240	32	library	library	NN
cord-341050-hnuogpqn	240	33	[	[	-LRB-
cord-341050-hnuogpqn	240	34	307	307	CD
cord-341050-hnuogpqn	240	35	]	]	-RRB-
cord-341050-hnuogpqn	240	36	.	.	.
cord-341050-hnuogpqn	241	1	One	one	CD
cord-341050-hnuogpqn	241	2	of	of	IN
cord-341050-hnuogpqn	241	3	those	those	DT
cord-341050-hnuogpqn	241	4	peptides	peptide	NNS
cord-341050-hnuogpqn	241	5	(	(	-LRB-
cord-341050-hnuogpqn	241	6	P9	p9	NN
cord-341050-hnuogpqn	241	7	)	)	-RRB-
cord-341050-hnuogpqn	241	8	reduces	reduce	VBZ
cord-341050-hnuogpqn	241	9	viremia	viremia	NN
cord-341050-hnuogpqn	241	10	and	and	CC
cord-341050-hnuogpqn	241	11	fatality	fatality	NN
cord-341050-hnuogpqn	241	12	after	after	IN
cord-341050-hnuogpqn	241	13	WNV	WNV	NNP
cord-341050-hnuogpqn	241	14	infection	infection	NN
cord-341050-hnuogpqn	241	15	in	in	IN
cord-341050-hnuogpqn	241	16	mice	mouse	NNS
cord-341050-hnuogpqn	241	17	.	.	.
cord-341050-hnuogpqn	242	1	P9	p9	NN
cord-341050-hnuogpqn	242	2	can	can	MD
cord-341050-hnuogpqn	242	3	effi	effi	NNP
cord-341050-hnuogpqn	242	4	ciently	ciently	RB
cord-341050-hnuogpqn	242	5	penetrate	penetrate	VB
cord-341050-hnuogpqn	242	6	the	the	DT
cord-341050-hnuogpqn	242	7	murine	murine	JJ
cord-341050-hnuogpqn	242	8	blood	blood	NN
cord-341050-hnuogpqn	242	9	-	-	HYPH
cord-341050-hnuogpqn	242	10	brain	brain	NN
cord-341050-hnuogpqn	242	11	barrier	barrier	NN
cord-341050-hnuogpqn	242	12	,	,	,
cord-341050-hnuogpqn	242	13	implying	imply	VBG
cord-341050-hnuogpqn	242	14	that	that	IN
cord-341050-hnuogpqn	242	15	it	-PRON-	PRP
cord-341050-hnuogpqn	242	16	may	may	MD
cord-341050-hnuogpqn	242	17	have	have	VB
cord-341050-hnuogpqn	242	18	antiviral	antiviral	JJ
cord-341050-hnuogpqn	242	19	activity	activity	NN
cord-341050-hnuogpqn	242	20	in	in	IN
cord-341050-hnuogpqn	242	21	the	the	DT
cord-341050-hnuogpqn	242	22	CNS	CNS	NNP
cord-341050-hnuogpqn	242	23	[	[	-LRB-
cord-341050-hnuogpqn	242	24	307	307	CD
cord-341050-hnuogpqn	242	25	]	]	-RRB-
cord-341050-hnuogpqn	242	26	.	.	.
cord-341050-hnuogpqn	243	1	Similarly	similarly	RB
cord-341050-hnuogpqn	243	2	,	,	,
cord-341050-hnuogpqn	243	3	a	a	DT
cord-341050-hnuogpqn	243	4	peptide	peptide	JJ
cord-341050-hnuogpqn	243	5	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	243	6	(	(	-LRB-
cord-341050-hnuogpqn	243	7	WN83	WN83	NNP
cord-341050-hnuogpqn	243	8	)	)	-RRB-
cord-341050-hnuogpqn	243	9	targeting	target	VBG
cord-341050-hnuogpqn	243	10	domain	domain	NN
cord-341050-hnuogpqn	243	11	II	ii	CD
cord-341050-hnuogpqn	243	12	of	of	IN
cord-341050-hnuogpqn	243	13	WNV	WNV	NNP
cord-341050-hnuogpqn	243	14	E	E	NNP
cord-341050-hnuogpqn	243	15	protein	protein	NN
cord-341050-hnuogpqn	243	16	designed	design	VBN
cord-341050-hnuogpqn	243	17	by	by	IN
cord-341050-hnuogpqn	243	18	using	use	VBG
cord-341050-hnuogpqn	243	19	a	a	DT
cord-341050-hnuogpqn	243	20	physicochemical	physicochemical	JJ
cord-341050-hnuogpqn	243	21	algorithm	algorithm	NN
cord-341050-hnuogpqn	243	22	approach	approach	NN
cord-341050-hnuogpqn	243	23	potently	potently	RB
cord-341050-hnuogpqn	243	24	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	243	25	WNV	WNV	NNP
cord-341050-hnuogpqn	243	26	infectivity	infectivity	NN
cord-341050-hnuogpqn	243	27	[	[	-LRB-
cord-341050-hnuogpqn	243	28	308	308	CD
cord-341050-hnuogpqn	243	29	]	]	-RRB-
cord-341050-hnuogpqn	243	30	.	.	.
cord-341050-hnuogpqn	244	1	Another	another	DT
cord-341050-hnuogpqn	244	2	peptide	peptide	NN
cord-341050-hnuogpqn	244	3	designed	design	VBN
cord-341050-hnuogpqn	244	4	to	to	TO
cord-341050-hnuogpqn	244	5	target	target	VB
cord-341050-hnuogpqn	244	6	domain	domain	NN
cord-341050-hnuogpqn	244	7	II	ii	CD
cord-341050-hnuogpqn	244	8	of	of	IN
cord-341050-hnuogpqn	244	9	DENV	DENV	NNP
cord-341050-hnuogpqn	244	10	E	E	NNP
cord-341050-hnuogpqn	244	11	shows	show	VBZ
cord-341050-hnuogpqn	244	12	antiviral	antiviral	JJ
cord-341050-hnuogpqn	244	13	activity	activity	NN
cord-341050-hnuogpqn	244	14	against	against	IN
cord-341050-hnuogpqn	244	15	both	both	CC
cord-341050-hnuogpqn	244	16	DENV	DENV	NNP
cord-341050-hnuogpqn	244	17	and	and	CC
cord-341050-hnuogpqn	244	18	WNV	WNV	NNP
cord-341050-hnuogpqn	244	19	[	[	-LRB-
cord-341050-hnuogpqn	244	20	308	308	CD
cord-341050-hnuogpqn	244	21	]	]	-RRB-
cord-341050-hnuogpqn	244	22	.	.	.
cord-341050-hnuogpqn	245	1	In	in	IN
cord-341050-hnuogpqn	245	2	addition	addition	NN
cord-341050-hnuogpqn	245	3	,	,	,
cord-341050-hnuogpqn	245	4	a	a	DT
cord-341050-hnuogpqn	245	5	rational	rational	JJ
cord-341050-hnuogpqn	245	6	drug	drug	NN
cord-341050-hnuogpqn	245	7	design	design	NN
cord-341050-hnuogpqn	245	8	approach	approach	NN
cord-341050-hnuogpqn	245	9	has	have	VBZ
cord-341050-hnuogpqn	245	10	been	be	VBN
cord-341050-hnuogpqn	245	11	used	use	VBN
cord-341050-hnuogpqn	245	12	to	to	TO
cord-341050-hnuogpqn	245	13	identify	identify	VB
cord-341050-hnuogpqn	245	14	a	a	DT
cord-341050-hnuogpqn	245	15	peptidomimetic	peptidomimetic	NN
cord-341050-hnuogpqn	245	16	that	that	WDT
cord-341050-hnuogpqn	245	17	mimic	mimic	VBP
cord-341050-hnuogpqn	245	18	NS2B	NS2B	NNP
cord-341050-hnuogpqn	245	19	/	/	SYM
cord-341050-hnuogpqn	245	20	NS3	ns3	RB
cord-341050-hnuogpqn	245	21	protease	protease	NN
cord-341050-hnuogpqn	245	22	substrate	substrate	NN
cord-341050-hnuogpqn	245	23	and	and	CC
cord-341050-hnuogpqn	245	24	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	245	25	its	-PRON-	PRP$
cord-341050-hnuogpqn	245	26	activity	activity	NN
cord-341050-hnuogpqn	245	27	.	.	.
cord-341050-hnuogpqn	246	1	The	the	DT
cord-341050-hnuogpqn	246	2	mechanism	mechanism	NN
cord-341050-hnuogpqn	246	3	proposed	propose	VBN
cord-341050-hnuogpqn	246	4	for	for	IN
cord-341050-hnuogpqn	246	5	the	the	DT
cord-341050-hnuogpqn	246	6	peptidomimetic	peptidomimetic	NNP
cord-341050-hnuogpqn	246	7	is	be	VBZ
cord-341050-hnuogpqn	246	8	that	that	DT
cord-341050-hnuogpqn	246	9	NS2B	NS2B	NNP
cord-341050-hnuogpqn	246	10	/	/	,
cord-341050-hnuogpqn	246	11	NS3	ns3	RB
cord-341050-hnuogpqn	246	12	cleaves	cleave	VBZ
cord-341050-hnuogpqn	246	13	between	between	IN
cord-341050-hnuogpqn	246	14	P	p	NN
cord-341050-hnuogpqn	246	15	1	1	CD
cord-341050-hnuogpqn	246	16	and	and	CC
cord-341050-hnuogpqn	246	17	P	p	NN
cord-341050-hnuogpqn	246	18	1	1	CD
cord-341050-hnuogpqn	246	19	′	′	CD
cord-341050-hnuogpqn	246	20	in	in	IN
cord-341050-hnuogpqn	246	21	a	a	DT
cord-341050-hnuogpqn	246	22	peptide	peptide	NN
cord-341050-hnuogpqn	246	23	substrate	substrate	NN
cord-341050-hnuogpqn	246	24	consisting	consist	VBG
cord-341050-hnuogpqn	246	25	of	of	IN
cord-341050-hnuogpqn	246	26	P	p	NN
cord-341050-hnuogpqn	246	27	2	2	CD
cord-341050-hnuogpqn	246	28	P	p	NN
cord-341050-hnuogpqn	246	29	1	1	CD
cord-341050-hnuogpqn	246	30	P	p	NN
cord-341050-hnuogpqn	246	31	1	1	CD
cord-341050-hnuogpqn	246	32	′	′	CD
cord-341050-hnuogpqn	246	33	,	,	,
cord-341050-hnuogpqn	246	34	where	where	WRB
cord-341050-hnuogpqn	246	35	P	p	NN
cord-341050-hnuogpqn	246	36	1	1	CD
cord-341050-hnuogpqn	246	37	and	and	CC
cord-341050-hnuogpqn	246	38	P	p	NN
cord-341050-hnuogpqn	246	39	2	2	CD
cord-341050-hnuogpqn	246	40	are	be	VBP
cord-341050-hnuogpqn	246	41	basic	basic	JJ
cord-341050-hnuogpqn	246	42	amino	amino	NN
cord-341050-hnuogpqn	246	43	acids	acid	NNS
cord-341050-hnuogpqn	246	44	(	(	-LRB-
cord-341050-hnuogpqn	246	45	Arg	Arg	NNP
cord-341050-hnuogpqn	246	46	or	or	CC
cord-341050-hnuogpqn	246	47	Lys	Lys	NNP
cord-341050-hnuogpqn	246	48	)	)	-RRB-
cord-341050-hnuogpqn	246	49	and	and	CC
cord-341050-hnuogpqn	247	1	P1′	P1′	NNP
cord-341050-hnuogpqn	247	2	is	be	VBZ
cord-341050-hnuogpqn	247	3	a	a	DT
cord-341050-hnuogpqn	247	4	side	side	NN
cord-341050-hnuogpqn	247	5	-	-	HYPH
cord-341050-hnuogpqn	247	6	chain	chain	NN
cord-341050-hnuogpqn	247	7	amino	amino	NN
cord-341050-hnuogpqn	247	8	acid	acid	NN
cord-341050-hnuogpqn	247	9	(	(	-LRB-
cord-341050-hnuogpqn	247	10	Gly	Gly	NNP
cord-341050-hnuogpqn	247	11	,	,	,
cord-341050-hnuogpqn	247	12	Ser	Ser	NNP
cord-341050-hnuogpqn	247	13	,	,	,
cord-341050-hnuogpqn	247	14	or	or	CC
cord-341050-hnuogpqn	247	15	Ala	Ala	NNP
cord-341050-hnuogpqn	247	16	)	)	-RRB-
cord-341050-hnuogpqn	248	1	[	[	-LRB-
cord-341050-hnuogpqn	248	2	56	56	CD
cord-341050-hnuogpqn	248	3	,	,	,
cord-341050-hnuogpqn	248	4	231	231	CD
cord-341050-hnuogpqn	248	5	]	]	-RRB-
cord-341050-hnuogpqn	248	6	.	.	.
cord-341050-hnuogpqn	249	1	Thus	thus	RB
cord-341050-hnuogpqn	249	2	,	,	,
cord-341050-hnuogpqn	249	3	a	a	DT
cord-341050-hnuogpqn	249	4	preferred	preferred	JJ
cord-341050-hnuogpqn	249	5	peptide	peptide	NN
cord-341050-hnuogpqn	249	6	substrate	substrate	NN
cord-341050-hnuogpqn	249	7	contains	contain	VBZ
cord-341050-hnuogpqn	249	8	several	several	JJ
cord-341050-hnuogpqn	249	9	positively	positively	RB
cord-341050-hnuogpqn	249	10	charged	charge	VBN
cord-341050-hnuogpqn	249	11	amino	amino	NN
cord-341050-hnuogpqn	249	12	acids	acid	NNS
cord-341050-hnuogpqn	249	13	.	.	.
cord-341050-hnuogpqn	250	1	A	a	DT
cord-341050-hnuogpqn	250	2	common	common	JJ
cord-341050-hnuogpqn	250	3	method	method	NN
cord-341050-hnuogpqn	250	4	for	for	IN
cord-341050-hnuogpqn	250	5	screening	screen	VBG
cord-341050-hnuogpqn	250	6	peptide	peptide	JJ
cord-341050-hnuogpqn	250	7	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	250	8	of	of	IN
cord-341050-hnuogpqn	250	9	NS2B	NS2B	NNP
cord-341050-hnuogpqn	250	10	/	/	SYM
cord-341050-hnuogpqn	250	11	NS3	ns3	RB
cord-341050-hnuogpqn	250	12	protease	protease	NN
cord-341050-hnuogpqn	250	13	employs	employ	VBZ
cord-341050-hnuogpqn	250	14	a	a	DT
cord-341050-hnuogpqn	250	15	fl	fl	NNP
cord-341050-hnuogpqn	250	16	uorophore	uorophore	NN
cord-341050-hnuogpqn	250	17	conjugated	conjugate	VBN
cord-341050-hnuogpqn	250	18	peptide	peptide	NN
cord-341050-hnuogpqn	250	19	substrate	substrate	NN
cord-341050-hnuogpqn	250	20	containing	contain	VBG
cord-341050-hnuogpqn	250	21	basic	basic	JJ
cord-341050-hnuogpqn	250	22	amino	amino	NN
cord-341050-hnuogpqn	250	23	acids	acid	NNS
cord-341050-hnuogpqn	250	24	at	at	IN
cord-341050-hnuogpqn	250	25	the	the	DT
cord-341050-hnuogpqn	250	26	P1	P1	NNP
cord-341050-hnuogpqn	250	27	and	and	CC
cord-341050-hnuogpqn	250	28	P2	P2	NNP
cord-341050-hnuogpqn	250	29	positions	position	NNS
cord-341050-hnuogpqn	250	30	.	.	.
cord-341050-hnuogpqn	251	1	Cleavage	cleavage	NN
cord-341050-hnuogpqn	251	2	of	of	IN
cord-341050-hnuogpqn	251	3	peptide	peptide	NN
cord-341050-hnuogpqn	251	4	substrate	substrate	NN
cord-341050-hnuogpqn	251	5	by	by	IN
cord-341050-hnuogpqn	252	1	NS2B	NS2B	NNP
cord-341050-hnuogpqn	252	2	/	/	,
cord-341050-hnuogpqn	252	3	NS3	ns3	RB
cord-341050-hnuogpqn	252	4	protease	protease	NN
cord-341050-hnuogpqn	252	5	results	result	NNS
cord-341050-hnuogpqn	252	6	in	in	IN
cord-341050-hnuogpqn	252	7	a	a	DT
cord-341050-hnuogpqn	252	8	release	release	NN
cord-341050-hnuogpqn	252	9	of	of	IN
cord-341050-hnuogpqn	252	10	fl	fl	NNP
cord-341050-hnuogpqn	252	11	uorophore	uorophore	NN
cord-341050-hnuogpqn	252	12	and	and	CC
cord-341050-hnuogpqn	252	13	increase	increase	NN
cord-341050-hnuogpqn	252	14	of	of	IN
cord-341050-hnuogpqn	252	15	fl	fl	NNP
cord-341050-hnuogpqn	252	16	uorescence	uorescence	NNP
cord-341050-hnuogpqn	252	17	[	[	-LRB-
cord-341050-hnuogpqn	252	18	242	242	CD
cord-341050-hnuogpqn	252	19	,	,	,
cord-341050-hnuogpqn	252	20	243	243	CD
cord-341050-hnuogpqn	252	21	]	]	-RRB-
cord-341050-hnuogpqn	252	22	.	.	.
cord-341050-hnuogpqn	253	1	Several	several	JJ
cord-341050-hnuogpqn	253	2	peptide	peptide	NN
cord-341050-hnuogpqn	253	3	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	253	4	of	of	IN
cord-341050-hnuogpqn	253	5	NS2B	NS2B	NNP
cord-341050-hnuogpqn	253	6	/	/	SYM
cord-341050-hnuogpqn	253	7	NS3	ns3	RB
cord-341050-hnuogpqn	253	8	protease	protease	NN
cord-341050-hnuogpqn	253	9	have	have	VBP
cord-341050-hnuogpqn	253	10	been	be	VBN
cord-341050-hnuogpqn	253	11	identifi	identifi	VBN
cord-341050-hnuogpqn	253	12	ed	ed	NN
cord-341050-hnuogpqn	253	13	against	against	IN
cord-341050-hnuogpqn	253	14	WNV	WNV	NNP
cord-341050-hnuogpqn	253	15	[	[	-LRB-
cord-341050-hnuogpqn	253	16	62	62	CD
cord-341050-hnuogpqn	253	17	,	,	,
cord-341050-hnuogpqn	253	18	309	309	CD
cord-341050-hnuogpqn	253	19	-311	-311	NN
cord-341050-hnuogpqn	253	20	]	]	-RRB-
cord-341050-hnuogpqn	253	21	.	.	.
cord-341050-hnuogpqn	254	1	A	a	DT
cord-341050-hnuogpqn	254	2	novel	novel	NN
cord-341050-hnuogpqn	254	3	agmatine	agmatine	NN
cord-341050-hnuogpqn	254	4	dipeptide	dipeptide	NN
cord-341050-hnuogpqn	254	5	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	254	6	with	with	IN
cord-341050-hnuogpqn	254	7	improved	improved	JJ
cord-341050-hnuogpqn	254	8	inhibitory	inhibitory	JJ
cord-341050-hnuogpqn	254	9	activity	activity	NN
cord-341050-hnuogpqn	254	10	against	against	IN
cord-341050-hnuogpqn	254	11	WNV	WNV	NNP
cord-341050-hnuogpqn	254	12	NS2B/	NS2B/	NNP
cord-341050-hnuogpqn	254	13	NS3	ns3	RB
cord-341050-hnuogpqn	254	14	has	have	VBZ
cord-341050-hnuogpqn	254	15	been	be	VBN
cord-341050-hnuogpqn	254	16	recently	recently	RB
cord-341050-hnuogpqn	254	17	identifi	identifi	VBN
cord-341050-hnuogpqn	254	18	ed	ed	NNP
cord-341050-hnuogpqn	254	19	[	[	-LRB-
cord-341050-hnuogpqn	254	20	309	309	CD
cord-341050-hnuogpqn	254	21	]	]	-RRB-
cord-341050-hnuogpqn	254	22	.	.	.
cord-341050-hnuogpqn	255	1	In	in	IN
cord-341050-hnuogpqn	255	2	addition	addition	NN
cord-341050-hnuogpqn	255	3	,	,	,
cord-341050-hnuogpqn	255	4	a	a	DT
cord-341050-hnuogpqn	255	5	recombinant	recombinant	JJ
cord-341050-hnuogpqn	255	6	peptide	peptide	NN
cord-341050-hnuogpqn	255	7	called	call	VBN
cord-341050-hnuogpqn	255	8	retrocyclin-1	retrocyclin-1	NNP
cord-341050-hnuogpqn	255	9	(	(	-LRB-
cord-341050-hnuogpqn	255	10	RC-1	RC-1	NNP
cord-341050-hnuogpqn	255	11	)	)	-RRB-
cord-341050-hnuogpqn	255	12	has	have	VBZ
cord-341050-hnuogpqn	255	13	been	be	VBN
cord-341050-hnuogpqn	255	14	shown	show	VBN
cord-341050-hnuogpqn	255	15	to	to	TO
cord-341050-hnuogpqn	255	16	inhibit	inhibit	VB
cord-341050-hnuogpqn	255	17	NS2B	NS2B	NNP
cord-341050-hnuogpqn	255	18	/	/	,
cord-341050-hnuogpqn	255	19	NS3	ns3	RB
cord-341050-hnuogpqn	255	20	protease	protease	NN
cord-341050-hnuogpqn	255	21	[	[	-LRB-
cord-341050-hnuogpqn	255	22	312	312	CD
cord-341050-hnuogpqn	255	23	]	]	-RRB-
cord-341050-hnuogpqn	255	24	.	.	.
cord-341050-hnuogpqn	256	1	However	however	RB
cord-341050-hnuogpqn	256	2	,	,	,
cord-341050-hnuogpqn	256	3	most	most	JJS
cord-341050-hnuogpqn	256	4	of	of	IN
cord-341050-hnuogpqn	256	5	these	these	DT
cord-341050-hnuogpqn	256	6	peptides	peptide	NNS
cord-341050-hnuogpqn	256	7	showed	show	VBD
cord-341050-hnuogpqn	256	8	poor	poor	JJ
cord-341050-hnuogpqn	256	9	activity	activity	NN
cord-341050-hnuogpqn	256	10	in	in	IN
cord-341050-hnuogpqn	256	11	the	the	DT
cord-341050-hnuogpqn	256	12	cell	cell	NN
cord-341050-hnuogpqn	256	13	-	-	HYPH
cord-341050-hnuogpqn	256	14	based	base	VBN
cord-341050-hnuogpqn	256	15	assay	assay	NN
cord-341050-hnuogpqn	256	16	and	and	CC
cord-341050-hnuogpqn	256	17	has	have	VBZ
cord-341050-hnuogpqn	256	18	not	not	RB
cord-341050-hnuogpqn	256	19	been	be	VBN
cord-341050-hnuogpqn	256	20	tested	test	VBN
cord-341050-hnuogpqn	256	21	for	for	IN
cord-341050-hnuogpqn	256	22	their	-PRON-	PRP$
cord-341050-hnuogpqn	256	23	in	in	IN
cord-341050-hnuogpqn	256	24	vivo	vivo	FW
cord-341050-hnuogpqn	256	25	effi	effi	FW
cord-341050-hnuogpqn	256	26	cacy	cacy	NNP
cord-341050-hnuogpqn	256	27	.	.	.
cord-341050-hnuogpqn	257	1	Thus	thus	RB
cord-341050-hnuogpqn	257	2	,	,	,
cord-341050-hnuogpqn	257	3	all	all	DT
cord-341050-hnuogpqn	257	4	of	of	IN
cord-341050-hnuogpqn	257	5	the	the	DT
cord-341050-hnuogpqn	257	6	peptide	peptide	JJ
cord-341050-hnuogpqn	257	7	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	257	8	of	of	IN
cord-341050-hnuogpqn	257	9	NS2B/	NS2B/	NNP
cord-341050-hnuogpqn	257	10	NS3	NS3	NNP
cord-341050-hnuogpqn	257	11	protease	protease	NN
cord-341050-hnuogpqn	257	12	that	that	WDT
cord-341050-hnuogpqn	257	13	has	have	VBZ
cord-341050-hnuogpqn	257	14	been	be	VBN
cord-341050-hnuogpqn	257	15	identifi	identifi	VBN
cord-341050-hnuogpqn	257	16	ed	ed	NNP
cord-341050-hnuogpqn	257	17	so	so	RB
cord-341050-hnuogpqn	257	18	far	far	RB
cord-341050-hnuogpqn	257	19	failed	fail	VBD
cord-341050-hnuogpqn	257	20	at	at	IN
cord-341050-hnuogpqn	257	21	the	the	DT
cord-341050-hnuogpqn	257	22	early	early	JJ
cord-341050-hnuogpqn	257	23	development	development	NN
cord-341050-hnuogpqn	257	24	stages	stage	NNS
cord-341050-hnuogpqn	257	25	.	.	.
cord-341050-hnuogpqn	258	1	Potential	potential	JJ
cord-341050-hnuogpqn	258	2	limitations	limitation	NNS
cord-341050-hnuogpqn	258	3	of	of	IN
cord-341050-hnuogpqn	258	4	this	this	DT
cord-341050-hnuogpqn	258	5	approach	approach	NN
cord-341050-hnuogpqn	258	6	include	include	VBP
cord-341050-hnuogpqn	258	7	poor	poor	JJ
cord-341050-hnuogpqn	258	8	pharmacokinetic	pharmacokinetic	JJ
cord-341050-hnuogpqn	258	9	properties	property	NNS
cord-341050-hnuogpqn	258	10	due	due	JJ
cord-341050-hnuogpqn	258	11	to	to	IN
cord-341050-hnuogpqn	258	12	charged	charge	VBN
cord-341050-hnuogpqn	258	13	nature	nature	NN
cord-341050-hnuogpqn	258	14	of	of	IN
cord-341050-hnuogpqn	258	15	peptide	peptide	NN
cord-341050-hnuogpqn	258	16	,	,	,
cord-341050-hnuogpqn	258	17	lack	lack	NN
cord-341050-hnuogpqn	258	18	of	of	IN
cord-341050-hnuogpqn	258	19	specifi	specifi	NN
cord-341050-hnuogpqn	258	20	city	city	NN
cord-341050-hnuogpqn	258	21	,	,	,
cord-341050-hnuogpqn	258	22	requirement	requirement	NN
cord-341050-hnuogpqn	258	23	of	of	IN
cord-341050-hnuogpqn	258	24	intravenous	intravenous	JJ
cord-341050-hnuogpqn	258	25	delivery	delivery	NN
cord-341050-hnuogpqn	258	26	,	,	,
cord-341050-hnuogpqn	258	27	rapid	rapid	JJ
cord-341050-hnuogpqn	258	28	degradation	degradation	NN
cord-341050-hnuogpqn	258	29	in	in	IN
cord-341050-hnuogpqn	258	30	plasma	plasma	NN
cord-341050-hnuogpqn	258	31	,	,	,
cord-341050-hnuogpqn	258	32	and	and	CC
cord-341050-hnuogpqn	258	33	costly	costly	JJ
cord-341050-hnuogpqn	258	34	production	production	NN
cord-341050-hnuogpqn	258	35	.	.	.
cord-341050-hnuogpqn	259	1	Dhiraj	Dhiraj	NNP
cord-341050-hnuogpqn	259	2	Acharya	Acharya	NNP
cord-341050-hnuogpqn	259	3	and	and	CC
cord-341050-hnuogpqn	259	4	Fengwei	Fengwei	NNP
cord-341050-hnuogpqn	259	5	Bai	Bai	NNP
cord-341050-hnuogpqn	259	6	RNA	RNA	NNP
cord-341050-hnuogpqn	259	7	interference	interference	NN
cord-341050-hnuogpqn	259	8	(	(	-LRB-
cord-341050-hnuogpqn	259	9	RNAi	RNAi	NNP
cord-341050-hnuogpqn	259	10	)	)	-RRB-
cord-341050-hnuogpqn	259	11	is	be	VBZ
cord-341050-hnuogpqn	259	12	a	a	DT
cord-341050-hnuogpqn	259	13	cellular	cellular	JJ
cord-341050-hnuogpqn	259	14	process	process	NN
cord-341050-hnuogpqn	260	1	fi	fi	NNP
cord-341050-hnuogpqn	260	2	rst	rst	NNP
cord-341050-hnuogpqn	260	3	described	describe	VBN
cord-341050-hnuogpqn	260	4	in	in	IN
cord-341050-hnuogpqn	260	5	the	the	DT
cord-341050-hnuogpqn	260	6	nematode	nematode	NN
cord-341050-hnuogpqn	260	7	Caenorhabditis	Caenorhabditis	NNP
cord-341050-hnuogpqn	260	8	elegans	elegan	NNS
cord-341050-hnuogpqn	260	9	[	[	-LRB-
cord-341050-hnuogpqn	260	10	313	313	CD
cord-341050-hnuogpqn	260	11	,	,	,
cord-341050-hnuogpqn	260	12	314	314	CD
cord-341050-hnuogpqn	260	13	]	]	-RRB-
cord-341050-hnuogpqn	260	14	.	.	.
cord-341050-hnuogpqn	261	1	This	this	DT
cord-341050-hnuogpqn	261	2	process	process	NN
cord-341050-hnuogpqn	261	3	specifically	specifically	RB
cord-341050-hnuogpqn	261	4	degrades	degrade	VBZ
cord-341050-hnuogpqn	261	5	RNA	RNA	NNP
cord-341050-hnuogpqn	261	6	in	in	IN
cord-341050-hnuogpqn	261	7	a	a	DT
cord-341050-hnuogpqn	261	8	sequence	sequence	NN
cord-341050-hnuogpqn	261	9	-	-	HYPH
cord-341050-hnuogpqn	261	10	specifi	specifi	VBN
cord-341050-hnuogpqn	261	11	c	c	NN
cord-341050-hnuogpqn	261	12	manner	manner	NN
cord-341050-hnuogpqn	261	13	and	and	CC
cord-341050-hnuogpqn	261	14	is	be	VBZ
cord-341050-hnuogpqn	261	15	conserved	conserve	VBN
cord-341050-hnuogpqn	261	16	in	in	IN
cord-341050-hnuogpqn	261	17	mammalian	mammalian	JJ
cord-341050-hnuogpqn	261	18	cells	cell	NNS
cord-341050-hnuogpqn	261	19	[	[	-LRB-
cord-341050-hnuogpqn	261	20	315	315	CD
cord-341050-hnuogpqn	261	21	,	,	,
cord-341050-hnuogpqn	261	22	316	316	CD
cord-341050-hnuogpqn	261	23	]	]	-RRB-
cord-341050-hnuogpqn	261	24	.	.	.
cord-341050-hnuogpqn	262	1	RNAi	RNAi	NNP
cord-341050-hnuogpqn	262	2	is	be	VBZ
cord-341050-hnuogpqn	262	3	a	a	DT
cord-341050-hnuogpqn	262	4	natural	natural	JJ
cord-341050-hnuogpqn	262	5	defense	defense	NN
cord-341050-hnuogpqn	262	6	of	of	IN
cord-341050-hnuogpqn	262	7	eukaryotic	eukaryotic	JJ
cord-341050-hnuogpqn	262	8	cells	cell	NNS
cord-341050-hnuogpqn	262	9	against	against	IN
cord-341050-hnuogpqn	262	10	viral	viral	JJ
cord-341050-hnuogpqn	262	11	infections	infection	NNS
cord-341050-hnuogpqn	262	12	,	,	,
cord-341050-hnuogpqn	262	13	and	and	CC
cord-341050-hnuogpqn	262	14	may	may	MD
cord-341050-hnuogpqn	262	15	be	be	VB
cord-341050-hnuogpqn	262	16	a	a	DT
cord-341050-hnuogpqn	262	17	promising	promising	JJ
cord-341050-hnuogpqn	262	18	strategy	strategy	NN
cord-341050-hnuogpqn	262	19	for	for	IN
cord-341050-hnuogpqn	262	20	developing	develop	VBG
cord-341050-hnuogpqn	262	21	a	a	DT
cord-341050-hnuogpqn	262	22	potential	potential	JJ
cord-341050-hnuogpqn	262	23	antiviral	antiviral	JJ
cord-341050-hnuogpqn	262	24	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	262	25	.	.	.
cord-341050-hnuogpqn	263	1	Numerous	numerous	JJ
cord-341050-hnuogpqn	263	2	siRNA	siRNA	NNP
cord-341050-hnuogpqn	263	3	targets	target	NNS
cord-341050-hnuogpqn	263	4	were	be	VBD
cord-341050-hnuogpqn	263	5	identifi	identifi	NNP
cord-341050-hnuogpqn	263	6	ed	ed	NNP
cord-341050-hnuogpqn	263	7	in	in	IN
cord-341050-hnuogpqn	263	8	the	the	DT
cord-341050-hnuogpqn	263	9	genomic	genomic	JJ
cord-341050-hnuogpqn	263	10	region	region	NN
cord-341050-hnuogpqn	263	11	of	of	IN
cord-341050-hnuogpqn	263	12	WNV	WNV	NNP
cord-341050-hnuogpqn	263	13	encoding	encode	VBG
cord-341050-hnuogpqn	263	14	both	both	CC
cord-341050-hnuogpqn	263	15	structural	structural	JJ
cord-341050-hnuogpqn	263	16	and	and	CC
cord-341050-hnuogpqn	263	17	non	non	JJ
cord-341050-hnuogpqn	263	18	-	-	JJ
cord-341050-hnuogpqn	263	19	structural	structural	JJ
cord-341050-hnuogpqn	263	20	proteins	protein	NNS
cord-341050-hnuogpqn	263	21	,	,	,
cord-341050-hnuogpqn	263	22	and	and	CC
cord-341050-hnuogpqn	263	23	siRNA	sirna	NN
cord-341050-hnuogpqn	263	24	targeting	target	VBG
cord-341050-hnuogpqn	263	25	these	these	DT
cord-341050-hnuogpqn	263	26	proteins	protein	NNS
cord-341050-hnuogpqn	263	27	effectively	effectively	RB
cord-341050-hnuogpqn	263	28	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	263	29	WNV	WNV	NNP
cord-341050-hnuogpqn	263	30	replication	replication	NN
cord-341050-hnuogpqn	263	31	[	[	-LRB-
cord-341050-hnuogpqn	263	32	191	191	CD
cord-341050-hnuogpqn	263	33	,	,	,
cord-341050-hnuogpqn	263	34	317	317	CD
cord-341050-hnuogpqn	263	35	-321	-321	NN
cord-341050-hnuogpqn	263	36	]	]	-RRB-
cord-341050-hnuogpqn	263	37	.	.	.
cord-341050-hnuogpqn	264	1	Besides	besides	IN
cord-341050-hnuogpqn	264	2	the	the	DT
cord-341050-hnuogpqn	264	3	siRNA	siRNA	NNP
cord-341050-hnuogpqn	264	4	targeting	target	VBG
cord-341050-hnuogpqn	264	5	coding	code	VBG
cord-341050-hnuogpqn	264	6	regions	region	NNS
cord-341050-hnuogpqn	264	7	,	,	,
cord-341050-hnuogpqn	264	8	siRNA	siRNA	NNP
cord-341050-hnuogpqn	264	9	that	that	IN
cord-341050-hnuogpqn	264	10	targets	target	VBZ
cord-341050-hnuogpqn	264	11	noncoding	noncoding	JJ
cord-341050-hnuogpqn	264	12	regions	region	NNS
cord-341050-hnuogpqn	264	13	have	have	VBP
cord-341050-hnuogpqn	264	14	also	also	RB
cord-341050-hnuogpqn	264	15	been	be	VBN
cord-341050-hnuogpqn	264	16	identifi	identifi	VBN
cord-341050-hnuogpqn	264	17	ed	ed	NN
cord-341050-hnuogpqn	264	18	to	to	TO
cord-341050-hnuogpqn	264	19	inhibit	inhibit	VB
cord-341050-hnuogpqn	264	20	WNV	WNV	NNP
cord-341050-hnuogpqn	264	21	replication	replication	NN
cord-341050-hnuogpqn	264	22	in	in	IN
cord-341050-hnuogpqn	264	23	a	a	DT
cord-341050-hnuogpqn	264	24	sequence	sequence	NN
cord-341050-hnuogpqn	264	25	-	-	HYPH
cord-341050-hnuogpqn	264	26	specifi	specifi	VBN
cord-341050-hnuogpqn	264	27	c	c	NN
cord-341050-hnuogpqn	264	28	manner	manner	NN
cord-341050-hnuogpqn	264	29	[	[	-LRB-
cord-341050-hnuogpqn	264	30	191	191	CD
cord-341050-hnuogpqn	264	31	]	]	-RRB-
cord-341050-hnuogpqn	264	32	.	.	.
cord-341050-hnuogpqn	265	1	Although	although	IN
cord-341050-hnuogpqn	265	2	anti	anti	JJ
cord-341050-hnuogpqn	265	3	-	-	JJ
cord-341050-hnuogpqn	265	4	WNV	WNV	NNP
cord-341050-hnuogpqn	265	5	siRNAs	siRNAs	NNP
cord-341050-hnuogpqn	265	6	effi	effi	NNP
cord-341050-hnuogpqn	265	7	ciently	ciently	RB
cord-341050-hnuogpqn	265	8	block	block	VB
cord-341050-hnuogpqn	265	9	viral	viral	JJ
cord-341050-hnuogpqn	265	10	replication	replication	NN
cord-341050-hnuogpqn	265	11	in	in	IN
cord-341050-hnuogpqn	265	12	cell	cell	NN
cord-341050-hnuogpqn	265	13	cultures	culture	NNS
cord-341050-hnuogpqn	265	14	,	,	,
cord-341050-hnuogpqn	265	15	similar	similar	JJ
cord-341050-hnuogpqn	265	16	successes	success	NNS
cord-341050-hnuogpqn	265	17	are	be	VBP
cord-341050-hnuogpqn	265	18	diffi	diffi	JJ
cord-341050-hnuogpqn	265	19	cult	cult	NN
cord-341050-hnuogpqn	265	20	to	to	TO
cord-341050-hnuogpqn	265	21	achieve	achieve	VB
cord-341050-hnuogpqn	265	22	in	in	IN
cord-341050-hnuogpqn	265	23	animal	animal	NN
cord-341050-hnuogpqn	265	24	models	model	NNS
cord-341050-hnuogpqn	265	25	[	[	-LRB-
cord-341050-hnuogpqn	265	26	191	191	CD
cord-341050-hnuogpqn	265	27	]	]	-RRB-
cord-341050-hnuogpqn	265	28	.	.	.
cord-341050-hnuogpqn	266	1	Quick	quick	JJ
cord-341050-hnuogpqn	266	2	degradation	degradation	NN
cord-341050-hnuogpqn	266	3	by	by	IN
cord-341050-hnuogpqn	266	4	serum	serum	NN
cord-341050-hnuogpqn	266	5	nucleases	nuclease	NNS
cord-341050-hnuogpqn	266	6	,	,	,
cord-341050-hnuogpqn	266	7	failure	failure	NN
cord-341050-hnuogpqn	266	8	to	to	TO
cord-341050-hnuogpqn	266	9	reach	reach	VB
cord-341050-hnuogpqn	266	10	target	target	NN
cord-341050-hnuogpqn	266	11	cells	cell	NNS
cord-341050-hnuogpqn	266	12	,	,	,
cord-341050-hnuogpqn	266	13	and	and	CC
cord-341050-hnuogpqn	266	14	rapid	rapid	JJ
cord-341050-hnuogpqn	266	15	renal	renal	JJ
cord-341050-hnuogpqn	266	16	excretion	excretion	NN
cord-341050-hnuogpqn	266	17	due	due	IN
cord-341050-hnuogpqn	266	18	to	to	IN
cord-341050-hnuogpqn	266	19	their	-PRON-	PRP$
cord-341050-hnuogpqn	266	20	small	small	JJ
cord-341050-hnuogpqn	266	21	size	size	NN
cord-341050-hnuogpqn	266	22	and	and	CC
cord-341050-hnuogpqn	266	23	anionic	anionic	JJ
cord-341050-hnuogpqn	266	24	character	character	NN
cord-341050-hnuogpqn	266	25	are	be	VBP
cord-341050-hnuogpqn	266	26	hindering	hinder	VBG
cord-341050-hnuogpqn	266	27	the	the	DT
cord-341050-hnuogpqn	266	28	clinical	clinical	JJ
cord-341050-hnuogpqn	266	29	application	application	NN
cord-341050-hnuogpqn	266	30	of	of	IN
cord-341050-hnuogpqn	266	31	antiviral	antiviral	JJ
cord-341050-hnuogpqn	266	32	siRNAs	siRNAs	NNP
cord-341050-hnuogpqn	266	33	.	.	.
cord-341050-hnuogpqn	267	1	Several	several	JJ
cord-341050-hnuogpqn	267	2	delivery	delivery	NN
cord-341050-hnuogpqn	267	3	systems	system	NNS
cord-341050-hnuogpqn	267	4	,	,	,
cord-341050-hnuogpqn	267	5	including	include	VBG
cord-341050-hnuogpqn	267	6	cell	cell	NN
cord-341050-hnuogpqn	267	7	-	-	HYPH
cord-341050-hnuogpqn	267	8	penetrating	penetrate	VBG
cord-341050-hnuogpqn	267	9	peptide	peptide	NN
cord-341050-hnuogpqn	267	10	[	[	-LRB-
cord-341050-hnuogpqn	267	11	322	322	CD
cord-341050-hnuogpqn	267	12	,	,	,
cord-341050-hnuogpqn	267	13	323	323	CD
cord-341050-hnuogpqn	267	14	]	]	-RRB-
cord-341050-hnuogpqn	267	15	,	,	,
cord-341050-hnuogpqn	267	16	nanoparticles	nanoparticle	NNS
cord-341050-hnuogpqn	267	17	[	[	-LRB-
cord-341050-hnuogpqn	267	18	324	324	CD
cord-341050-hnuogpqn	267	19	,	,	,
cord-341050-hnuogpqn	267	20	325	325	CD
cord-341050-hnuogpqn	267	21	]	]	-RRB-
cord-341050-hnuogpqn	267	22	,	,	,
cord-341050-hnuogpqn	267	23	and	and	CC
cord-341050-hnuogpqn	267	24	viral	viral	JJ
cord-341050-hnuogpqn	267	25	vectors	vector	NNS
cord-341050-hnuogpqn	267	26	[	[	-LRB-
cord-341050-hnuogpqn	267	27	326	326	CD
cord-341050-hnuogpqn	267	28	]	]	-RRB-
cord-341050-hnuogpqn	267	29	,	,	,
cord-341050-hnuogpqn	267	30	may	may	MD
cord-341050-hnuogpqn	267	31	improve	improve	VB
cord-341050-hnuogpqn	267	32	siRNA	siRNA	NNP
cord-341050-hnuogpqn	267	33	stability	stability	NN
cord-341050-hnuogpqn	267	34	and	and	CC
cord-341050-hnuogpqn	267	35	enhance	enhance	VB
cord-341050-hnuogpqn	267	36	delivery	delivery	NN
cord-341050-hnuogpqn	267	37	effi	effi	NNP
cord-341050-hnuogpqn	267	38	ciency	ciency	NNP
cord-341050-hnuogpqn	267	39	.	.	.
cord-341050-hnuogpqn	268	1	Despite	despite	IN
cord-341050-hnuogpqn	268	2	many	many	JJ
cord-341050-hnuogpqn	268	3	challenges	challenge	NNS
cord-341050-hnuogpqn	268	4	,	,	,
cord-341050-hnuogpqn	268	5	use	use	NN
cord-341050-hnuogpqn	268	6	of	of	IN
cord-341050-hnuogpqn	268	7	antiviral	antiviral	JJ
cord-341050-hnuogpqn	268	8	siRNA	siRNA	NNP
cord-341050-hnuogpqn	268	9	as	as	IN
cord-341050-hnuogpqn	268	10	anti	anti	JJ
cord-341050-hnuogpqn	268	11	-	-	JJ
cord-341050-hnuogpqn	268	12	WNV	WNV	NNP
cord-341050-hnuogpqn	268	13	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	268	14	remains	remain	VBZ
cord-341050-hnuogpqn	268	15	promising	promising	JJ
cord-341050-hnuogpqn	268	16	.	.	.
cord-341050-hnuogpqn	269	1	Cytokines	cytokine	NNS
cord-341050-hnuogpqn	269	2	signaling	signal	VBG
cord-341050-hnuogpqn	269	3	controls	control	NNS
cord-341050-hnuogpqn	269	4	diverse	diverse	JJ
cord-341050-hnuogpqn	269	5	immune	immune	JJ
cord-341050-hnuogpqn	269	6	functions	function	NNS
cord-341050-hnuogpqn	269	7	during	during	IN
cord-341050-hnuogpqn	269	8	infection	infection	NN
cord-341050-hnuogpqn	269	9	,	,	,
cord-341050-hnuogpqn	269	10	autoimmune	autoimmune	JJ
cord-341050-hnuogpqn	269	11	disease	disease	NN
cord-341050-hnuogpqn	269	12	,	,	,
cord-341050-hnuogpqn	269	13	and	and	CC
cord-341050-hnuogpqn	269	14	cancer	cancer	NN
cord-341050-hnuogpqn	269	15	.	.	.
cord-341050-hnuogpqn	270	1	Various	various	JJ
cord-341050-hnuogpqn	270	2	immunomodulatory	immunomodulatory	NN
cord-341050-hnuogpqn	270	3	or	or	CC
cord-341050-hnuogpqn	270	4	immunostimulatory	immunostimulatory	NNP
cord-341050-hnuogpqn	270	5	cytokines	cytokine	NNS
cord-341050-hnuogpqn	270	6	and	and	CC
cord-341050-hnuogpqn	270	7	chemokines	chemokine	NNS
cord-341050-hnuogpqn	270	8	have	have	VBP
cord-341050-hnuogpqn	270	9	been	be	VBN
cord-341050-hnuogpqn	270	10	identifi	identifi	VBN
cord-341050-hnuogpqn	270	11	ed	ed	NN
cord-341050-hnuogpqn	270	12	to	to	TO
cord-341050-hnuogpqn	270	13	play	play	VB
cord-341050-hnuogpqn	270	14	a	a	DT
cord-341050-hnuogpqn	270	15	protective	protective	JJ
cord-341050-hnuogpqn	270	16	or	or	CC
cord-341050-hnuogpqn	270	17	pathological	pathological	JJ
cord-341050-hnuogpqn	270	18	role	role	NN
cord-341050-hnuogpqn	270	19	in	in	IN
cord-341050-hnuogpqn	270	20	WNV	WNV	NNP
cord-341050-hnuogpqn	270	21	infection	infection	NN
cord-341050-hnuogpqn	270	22	.	.	.
cord-341050-hnuogpqn	271	1	For	for	IN
cord-341050-hnuogpqn	271	2	examples	example	NNS
cord-341050-hnuogpqn	271	3	,	,	,
cord-341050-hnuogpqn	271	4	type	type	NN
cord-341050-hnuogpqn	271	5	-	-	:
cord-341050-hnuogpqn	271	6	I	-PRON-	PRP
cord-341050-hnuogpqn	271	7	interferons	interferon	NNS
cord-341050-hnuogpqn	271	8	(	(	-LRB-
cord-341050-hnuogpqn	271	9	IFNs	IFNs	NNP
cord-341050-hnuogpqn	271	10	)	)	-RRB-
cord-341050-hnuogpqn	271	11	[	[	-LRB-
cord-341050-hnuogpqn	271	12	327	327	CD
cord-341050-hnuogpqn	271	13	,	,	,
cord-341050-hnuogpqn	271	14	328	328	CD
cord-341050-hnuogpqn	271	15	]	]	-RRB-
cord-341050-hnuogpqn	271	16	,	,	,
cord-341050-hnuogpqn	271	17	interleukin	interleukin	FW
cord-341050-hnuogpqn	271	18	(	(	-LRB-
cord-341050-hnuogpqn	271	19	IL)-23	il)-23	JJ
cord-341050-hnuogpqn	271	20	[	[	-LRB-
cord-341050-hnuogpqn	271	21	192	192	CD
cord-341050-hnuogpqn	271	22	]	]	-RRB-
cord-341050-hnuogpqn	271	23	,	,	,
cord-341050-hnuogpqn	271	24	interferon	interferon	NN
cord-341050-hnuogpqn	271	25	-	-	HYPH
cord-341050-hnuogpqn	271	26	γ	γ	NN
cord-341050-hnuogpqn	271	27	(	(	-LRB-
cord-341050-hnuogpqn	271	28	IFN	IFN	NNP
cord-341050-hnuogpqn	271	29	-	-	HYPH
cord-341050-hnuogpqn	271	30	γ	γ	NNP
cord-341050-hnuogpqn	271	31	)	)	-RRB-
cord-341050-hnuogpqn	271	32	[	[	-LRB-
cord-341050-hnuogpqn	271	33	83	83	CD
cord-341050-hnuogpqn	271	34	]	]	-RRB-
cord-341050-hnuogpqn	271	35	,	,	,
cord-341050-hnuogpqn	271	36	IL-1β	il-1β	ADD
cord-341050-hnuogpqn	271	37	[	[	-LRB-
cord-341050-hnuogpqn	271	38	329	329	CD
cord-341050-hnuogpqn	271	39	]	]	-RRB-
cord-341050-hnuogpqn	271	40	,	,	,
cord-341050-hnuogpqn	271	41	macrophage	macrophage	NN
cord-341050-hnuogpqn	271	42	migration	migration	NN
cord-341050-hnuogpqn	271	43	inhibitory	inhibitory	JJ
cord-341050-hnuogpqn	271	44	factor	factor	NN
cord-341050-hnuogpqn	271	45	(	(	-LRB-
cord-341050-hnuogpqn	271	46	MIF	MIF	NNP
cord-341050-hnuogpqn	271	47	)	)	-RRB-
cord-341050-hnuogpqn	271	48	[	[	-LRB-
cord-341050-hnuogpqn	271	49	330	330	CD
cord-341050-hnuogpqn	271	50	]	]	-RRB-
cord-341050-hnuogpqn	271	51	,	,	.
cord-341050-hnuogpqn	271	52	CXCL10	CXCL10	NNP
cord-341050-hnuogpqn	271	53	[	[	-LRB-
cord-341050-hnuogpqn	271	54	331	331	CD
cord-341050-hnuogpqn	271	55	]	]	-RRB-
cord-341050-hnuogpqn	271	56	,	,	,
cord-341050-hnuogpqn	271	57	and	and	CC
cord-341050-hnuogpqn	271	58	CCL5	CCL5	NNP
cord-341050-hnuogpqn	271	59	[	[	-LRB-
cord-341050-hnuogpqn	271	60	332	332	CD
cord-341050-hnuogpqn	271	61	,	,	,
cord-341050-hnuogpqn	271	62	333	333	CD
cord-341050-hnuogpqn	271	63	]	]	-RRB-
cord-341050-hnuogpqn	271	64	protect	protect	VBP
cord-341050-hnuogpqn	271	65	against	against	IN
cord-341050-hnuogpqn	271	66	WNV	WNV	NNP
cord-341050-hnuogpqn	271	67	infection	infection	NN
cord-341050-hnuogpqn	271	68	,	,	,
cord-341050-hnuogpqn	271	69	whereas	whereas	IN
cord-341050-hnuogpqn	271	70	IL-10	IL-10	NNP
cord-341050-hnuogpqn	271	71	[	[	-LRB-
cord-341050-hnuogpqn	271	72	190	190	CD
cord-341050-hnuogpqn	271	73	]	]	-RRB-
cord-341050-hnuogpqn	271	74	and	and	CC
cord-341050-hnuogpqn	271	75	IL-22	IL-22	NNP
cord-341050-hnuogpqn	271	76	[	[	-LRB-
cord-341050-hnuogpqn	271	77	334	334	CD
cord-341050-hnuogpqn	271	78	]	]	-RRB-
cord-341050-hnuogpqn	271	79	favor	favor	VBP
cord-341050-hnuogpqn	271	80	WNV	WNV	NNP
cord-341050-hnuogpqn	271	81	pathogenicity	pathogenicity	NN
cord-341050-hnuogpqn	271	82	.	.	.
cord-341050-hnuogpqn	272	1	Pharmacological	pharmacological	JJ
cord-341050-hnuogpqn	272	2	blockade	blockade	NN
cord-341050-hnuogpqn	272	3	of	of	IN
cord-341050-hnuogpqn	272	4	IL-10	IL-10	NNP
cord-341050-hnuogpqn	272	5	by	by	IN
cord-341050-hnuogpqn	272	6	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	272	7	antibody	antibody	NN
cord-341050-hnuogpqn	272	8	has	have	VBZ
cord-341050-hnuogpqn	272	9	been	be	VBN
cord-341050-hnuogpqn	272	10	shown	show	VBN
cord-341050-hnuogpqn	272	11	to	to	TO
cord-341050-hnuogpqn	272	12	protect	protect	VB
cord-341050-hnuogpqn	272	13	mice	mouse	NNS
cord-341050-hnuogpqn	272	14	against	against	IN
cord-341050-hnuogpqn	272	15	WNV	WNV	NNP
cord-341050-hnuogpqn	272	16	challenge	challenge	NN
cord-341050-hnuogpqn	272	17	[	[	-LRB-
cord-341050-hnuogpqn	272	18	190	190	CD
cord-341050-hnuogpqn	272	19	]	]	-RRB-
cord-341050-hnuogpqn	272	20	.	.	.
cord-341050-hnuogpqn	273	1	Type	type	NN
cord-341050-hnuogpqn	273	2	I	-PRON-	PRP
cord-341050-hnuogpqn	273	3	IFNs	ifns	NN
cord-341050-hnuogpqn	273	4	(	(	-LRB-
cord-341050-hnuogpqn	273	5	IFNα	IFNα	NNP
cord-341050-hnuogpqn	273	6	/	/	SYM
cord-341050-hnuogpqn	273	7	β	β	NN
cord-341050-hnuogpqn	273	8	)	)	-RRB-
cord-341050-hnuogpqn	273	9	inhibit	inhibit	VBP
cord-341050-hnuogpqn	273	10	many	many	JJ
cord-341050-hnuogpqn	273	11	fl	fl	NNP
cord-341050-hnuogpqn	273	12	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	273	13	including	include	VBG
cord-341050-hnuogpqn	273	14	WNV	WNV	NNP
cord-341050-hnuogpqn	273	15	and	and	CC
cord-341050-hnuogpqn	273	16	have	have	VBP
cord-341050-hnuogpqn	273	17	been	be	VBN
cord-341050-hnuogpqn	273	18	used	use	VBN
cord-341050-hnuogpqn	273	19	as	as	IN
cord-341050-hnuogpqn	273	20	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	273	21	against	against	IN
cord-341050-hnuogpqn	273	22	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	273	23	C	C	NNP
cord-341050-hnuogpqn	273	24	virus	virus	NN
cord-341050-hnuogpqn	273	25	[	[	-LRB-
cord-341050-hnuogpqn	273	26	335	335	CD
cord-341050-hnuogpqn	273	27	]	]	-RRB-
cord-341050-hnuogpqn	273	28	.	.	.
cord-341050-hnuogpqn	274	1	Although	although	IN
cord-341050-hnuogpqn	274	2	the	the	DT
cord-341050-hnuogpqn	274	3	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	274	4	effect	effect	NN
cord-341050-hnuogpqn	274	5	of	of	IN
cord-341050-hnuogpqn	274	6	type	type	NN
cord-341050-hnuogpqn	274	7	I	-PRON-	PRP
cord-341050-hnuogpqn	274	8	IFNs	ifns	VBP
cord-341050-hnuogpqn	274	9	in	in	IN
cord-341050-hnuogpqn	274	10	WNV	WNV	NNP
cord-341050-hnuogpqn	274	11	has	have	VBZ
cord-341050-hnuogpqn	274	12	yet	yet	RB
cord-341050-hnuogpqn	274	13	to	to	TO
cord-341050-hnuogpqn	274	14	be	be	VB
cord-341050-hnuogpqn	274	15	evaluated	evaluate	VBN
cord-341050-hnuogpqn	274	16	,	,	,
cord-341050-hnuogpqn	274	17	its	-PRON-	PRP$
cord-341050-hnuogpqn	274	18	application	application	NN
cord-341050-hnuogpqn	274	19	may	may	MD
cord-341050-hnuogpqn	274	20	be	be	VB
cord-341050-hnuogpqn	274	21	limited	limit	VBN
cord-341050-hnuogpqn	274	22	due	due	IN
cord-341050-hnuogpqn	274	23	to	to	IN
cord-341050-hnuogpqn	274	24	the	the	DT
cord-341050-hnuogpqn	274	25	antagonistic	antagonistic	JJ
cord-341050-hnuogpqn	274	26	role	role	NN
cord-341050-hnuogpqn	274	27	of	of	IN
cord-341050-hnuogpqn	274	28	WNV	WNV	NNP
cord-341050-hnuogpqn	274	29	NS5	ns5	JJ
cord-341050-hnuogpqn	274	30	protein	protein	NN
cord-341050-hnuogpqn	274	31	in	in	IN
cord-341050-hnuogpqn	274	32	IFN	IFN	NNP
cord-341050-hnuogpqn	274	33	signaling	signal	VBG
cord-341050-hnuogpqn	274	34	[	[	-LRB-
cord-341050-hnuogpqn	274	35	336	336	CD
cord-341050-hnuogpqn	274	36	,	,	,
cord-341050-hnuogpqn	274	37	337	337	CD
cord-341050-hnuogpqn	274	38	]	]	-RRB-
cord-341050-hnuogpqn	274	39	.	.	.
cord-341050-hnuogpqn	275	1	Interestingly	interestingly	RB
cord-341050-hnuogpqn	275	2	,	,	,
cord-341050-hnuogpqn	275	3	treatment	treatment	NN
cord-341050-hnuogpqn	275	4	with	with	IN
cord-341050-hnuogpqn	275	5	pegylated	pegylated	JJ
cord-341050-hnuogpqn	275	6	IFN	IFN	NNP
cord-341050-hnuogpqn	275	7	-	-	HYPH
cord-341050-hnuogpqn	275	8	λ	λ	NNP
cord-341050-hnuogpqn	275	9	,	,	,
cord-341050-hnuogpqn	275	10	also	also	RB
cord-341050-hnuogpqn	275	11	known	know	VBN
cord-341050-hnuogpqn	275	12	as	as	IN
cord-341050-hnuogpqn	275	13	a	a	DT
cord-341050-hnuogpqn	275	14	type	type	NN
cord-341050-hnuogpqn	275	15	III	iii	CD
cord-341050-hnuogpqn	275	16	interferon	interferon	NN
cord-341050-hnuogpqn	275	17	,	,	,
cord-341050-hnuogpqn	275	18	has	have	VBZ
cord-341050-hnuogpqn	275	19	been	be	VBN
cord-341050-hnuogpqn	275	20	recently	recently	RB
cord-341050-hnuogpqn	275	21	shown	show	VBN
cord-341050-hnuogpqn	275	22	to	to	TO
cord-341050-hnuogpqn	275	23	protect	protect	VB
cord-341050-hnuogpqn	275	24	mice	mouse	NNS
cord-341050-hnuogpqn	275	25	against	against	IN
cord-341050-hnuogpqn	275	26	lethal	lethal	JJ
cord-341050-hnuogpqn	275	27	WNV	WNV	NNP
cord-341050-hnuogpqn	275	28	infection	infection	NN
cord-341050-hnuogpqn	275	29	by	by	IN
cord-341050-hnuogpqn	275	30	decreasing	decrease	VBG
cord-341050-hnuogpqn	275	31	blood	blood	NN
cord-341050-hnuogpqn	275	32	-	-	HYPH
cord-341050-hnuogpqn	275	33	brain	brain	NN
cord-341050-hnuogpqn	275	34	barrier	barrier	NN
cord-341050-hnuogpqn	275	35	permeability	permeability	NN
cord-341050-hnuogpqn	275	36	[	[	-LRB-
cord-341050-hnuogpqn	275	37	338	338	CD
cord-341050-hnuogpqn	275	38	]	]	-RRB-
cord-341050-hnuogpqn	275	39	.	.	.
cord-341050-hnuogpqn	276	1	Thus	thus	RB
cord-341050-hnuogpqn	276	2	,	,	,
cord-341050-hnuogpqn	276	3	strategies	strategy	NNS
cord-341050-hnuogpqn	276	4	targeting	target	VBG
cord-341050-hnuogpqn	276	5	the	the	DT
cord-341050-hnuogpqn	276	6	expression	expression	NN
cord-341050-hnuogpqn	276	7	of	of	IN
cord-341050-hnuogpqn	276	8	cytokine	cytokine	NN
cord-341050-hnuogpqn	276	9	and	and	CC
cord-341050-hnuogpqn	276	10	chemokine	chemokine	NN
cord-341050-hnuogpqn	276	11	,	,	,
cord-341050-hnuogpqn	276	12	blocking	block	VBG
cord-341050-hnuogpqn	276	13	their	-PRON-	PRP$
cord-341050-hnuogpqn	276	14	signaling	signaling	NN
cord-341050-hnuogpqn	276	15	,	,	,
cord-341050-hnuogpqn	276	16	or	or	CC
cord-341050-hnuogpqn	276	17	direct	direct	JJ
cord-341050-hnuogpqn	276	18	use	use	NN
cord-341050-hnuogpqn	276	19	of	of	IN
cord-341050-hnuogpqn	276	20	recombinant	recombinant	JJ
cord-341050-hnuogpqn	276	21	cytokines	cytokine	NNS
cord-341050-hnuogpqn	276	22	may	may	MD
cord-341050-hnuogpqn	276	23	be	be	VB
cord-341050-hnuogpqn	276	24	novel	novel	JJ
cord-341050-hnuogpqn	276	25	approaches	approach	NNS
cord-341050-hnuogpqn	276	26	for	for	IN
cord-341050-hnuogpqn	276	27	treating	treat	VBG
cord-341050-hnuogpqn	276	28	WNV	WNV	NNP
cord-341050-hnuogpqn	276	29	infection	infection	NN
cord-341050-hnuogpqn	276	30	or	or	CC
cord-341050-hnuogpqn	276	31	controlling	control	VBG
cord-341050-hnuogpqn	276	32	its	-PRON-	PRP$
cord-341050-hnuogpqn	276	33	pathology	pathology	NN
cord-341050-hnuogpqn	276	34	.	.	.
cord-341050-hnuogpqn	277	1	Viruses	virus	NNS
cord-341050-hnuogpqn	277	2	utilize	utilize	VBP
cord-341050-hnuogpqn	277	3	host	host	NN
cord-341050-hnuogpqn	277	4	cellular	cellular	JJ
cord-341050-hnuogpqn	277	5	system	system	NN
cord-341050-hnuogpqn	277	6	for	for	IN
cord-341050-hnuogpqn	277	7	entry	entry	NN
cord-341050-hnuogpqn	277	8	,	,	,
cord-341050-hnuogpqn	277	9	genome	genome	NN
cord-341050-hnuogpqn	277	10	replication	replication	NN
cord-341050-hnuogpqn	277	11	,	,	,
cord-341050-hnuogpqn	277	12	transcription	transcription	NN
cord-341050-hnuogpqn	277	13	,	,	,
cord-341050-hnuogpqn	277	14	synthesis	synthesis	NN
cord-341050-hnuogpqn	277	15	of	of	IN
cord-341050-hnuogpqn	277	16	viral	viral	JJ
cord-341050-hnuogpqn	277	17	proteins	protein	NNS
cord-341050-hnuogpqn	277	18	,	,	,
cord-341050-hnuogpqn	277	19	and	and	CC
cord-341050-hnuogpqn	277	20	production	production	NN
cord-341050-hnuogpqn	277	21	of	of	IN
cord-341050-hnuogpqn	277	22	viral	viral	JJ
cord-341050-hnuogpqn	277	23	progenies	progeny	NNS
cord-341050-hnuogpqn	277	24	.	.	.
cord-341050-hnuogpqn	278	1	In	in	IN
cord-341050-hnuogpqn	278	2	addition	addition	NN
cord-341050-hnuogpqn	278	3	,	,	,
cord-341050-hnuogpqn	278	4	interactions	interaction	NNS
cord-341050-hnuogpqn	278	5	of	of	IN
cord-341050-hnuogpqn	278	6	viral	viral	JJ
cord-341050-hnuogpqn	278	7	proteins	protein	NNS
cord-341050-hnuogpqn	278	8	with	with	IN
cord-341050-hnuogpqn	278	9	cellular	cellular	JJ
cord-341050-hnuogpqn	278	10	proteins	protein	NNS
cord-341050-hnuogpqn	278	11	may	may	MD
cord-341050-hnuogpqn	278	12	evade	evade	VB
cord-341050-hnuogpqn	278	13	host	host	NN
cord-341050-hnuogpqn	278	14	immune	immune	JJ
cord-341050-hnuogpqn	278	15	defense	defense	NN
cord-341050-hnuogpqn	278	16	and	and	CC
cord-341050-hnuogpqn	278	17	favor	favor	VB
cord-341050-hnuogpqn	278	18	viral	viral	JJ
cord-341050-hnuogpqn	278	19	replication	replication	NN
cord-341050-hnuogpqn	278	20	and	and	CC
cord-341050-hnuogpqn	278	21	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	278	22	.	.	.
cord-341050-hnuogpqn	279	1	Several	several	JJ
cord-341050-hnuogpqn	279	2	host	host	NN
cord-341050-hnuogpqn	279	3	pathways	pathway	NNS
cord-341050-hnuogpqn	279	4	and	and	CC
cord-341050-hnuogpqn	279	5	enzymes	enzyme	NNS
cord-341050-hnuogpqn	279	6	including	include	VBG
cord-341050-hnuogpqn	279	7	clathrin	clathrin	NN
cord-341050-hnuogpqn	279	8	-	-	HYPH
cord-341050-hnuogpqn	279	9	mediated	mediate	VBN
cord-341050-hnuogpqn	279	10	endocytosis	endocytosis	NN
cord-341050-hnuogpqn	279	11	cyclophilins	cyclophilin	NNS
cord-341050-hnuogpqn	279	12	[	[	-LRB-
cord-341050-hnuogpqn	279	13	339	339	CD
cord-341050-hnuogpqn	279	14	]	]	-RRB-
cord-341050-hnuogpqn	279	15	,	,	,
cord-341050-hnuogpqn	279	16	ubiquitin	ubiquitin	NN
cord-341050-hnuogpqn	279	17	-	-	HYPH
cord-341050-hnuogpqn	279	18	proteasome	proteasome	VBN
cord-341050-hnuogpqn	279	19	system	system	NN
cord-341050-hnuogpqn	279	20	[	[	-LRB-
cord-341050-hnuogpqn	279	21	340	340	CD
cord-341050-hnuogpqn	279	22	]	]	-RRB-
cord-341050-hnuogpqn	279	23	,	,	,
cord-341050-hnuogpqn	279	24	unfolded	unfold	VBD
cord-341050-hnuogpqn	279	25	protein	protein	NN
cord-341050-hnuogpqn	279	26	response	response	NN
cord-341050-hnuogpqn	279	27	[	[	-LRB-
cord-341050-hnuogpqn	279	28	341	341	CD
cord-341050-hnuogpqn	279	29	]	]	-RRB-
cord-341050-hnuogpqn	279	30	,	,	,
cord-341050-hnuogpqn	279	31	nucleotide	nucleotide	JJ
cord-341050-hnuogpqn	279	32	biosynthesis	biosynthesis	NN
cord-341050-hnuogpqn	279	33	[	[	-LRB-
cord-341050-hnuogpqn	279	34	342	342	CD
cord-341050-hnuogpqn	279	35	,	,	,
cord-341050-hnuogpqn	279	36	343	343	CD
cord-341050-hnuogpqn	279	37	]	]	-RRB-
cord-341050-hnuogpqn	279	38	,	,	,
cord-341050-hnuogpqn	279	39	post	post	JJ
cord-341050-hnuogpqn	279	40	-	-	JJ
cord-341050-hnuogpqn	279	41	translational	translational	JJ
cord-341050-hnuogpqn	279	42	protein	protein	NN
cord-341050-hnuogpqn	279	43	modifi	modifi	NNP
cord-341050-hnuogpqn	279	44	cation	cation	NNP
cord-341050-hnuogpqn	279	45	[	[	-LRB-
cord-341050-hnuogpqn	279	46	344	344	CD
cord-341050-hnuogpqn	279	47	-346	-346	NN
cord-341050-hnuogpqn	279	48	]	]	-RRB-
cord-341050-hnuogpqn	279	49	,	,	,
cord-341050-hnuogpqn	279	50	and	and	CC
cord-341050-hnuogpqn	279	51	lipid	lipid	NN
cord-341050-hnuogpqn	279	52	metabolism	metabolism	NN
cord-341050-hnuogpqn	279	53	[	[	-LRB-
cord-341050-hnuogpqn	279	54	347	347	CD
cord-341050-hnuogpqn	279	55	-349	-349	VBP
cord-341050-hnuogpqn	279	56	]	]	-RRB-
cord-341050-hnuogpqn	279	57	have	have	VBP
cord-341050-hnuogpqn	279	58	been	be	VBN
cord-341050-hnuogpqn	279	59	suggested	suggest	VBN
cord-341050-hnuogpqn	279	60	in	in	IN
cord-341050-hnuogpqn	279	61	fl	fl	NNP
cord-341050-hnuogpqn	279	62	avivirus	avivirus	NNP
cord-341050-hnuogpqn	279	63	replication	replication	NN
cord-341050-hnuogpqn	279	64	and	and	CC
cord-341050-hnuogpqn	279	65	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	279	66	.	.	.
cord-341050-hnuogpqn	280	1	Targeting	target	VBG
cord-341050-hnuogpqn	280	2	host	host	NN
cord-341050-hnuogpqn	280	3	factors	factor	NNS
cord-341050-hnuogpqn	280	4	may	may	MD
cord-341050-hnuogpqn	280	5	be	be	VB
cord-341050-hnuogpqn	280	6	used	use	VBN
cord-341050-hnuogpqn	280	7	as	as	IN
cord-341050-hnuogpqn	280	8	a	a	DT
cord-341050-hnuogpqn	280	9	strategy	strategy	NN
cord-341050-hnuogpqn	280	10	for	for	IN
cord-341050-hnuogpqn	280	11	developing	develop	VBG
cord-341050-hnuogpqn	280	12	antiviral	antiviral	JJ
cord-341050-hnuogpqn	280	13	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	280	14	against	against	IN
cord-341050-hnuogpqn	280	15	fl	fl	NNP
cord-341050-hnuogpqn	280	16	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	280	17	,	,	,
cord-341050-hnuogpqn	280	18	including	include	VBG
cord-341050-hnuogpqn	280	19	WNV	WNV	NNP
cord-341050-hnuogpqn	280	20	infection	infection	NN
cord-341050-hnuogpqn	280	21	[	[	-LRB-
cord-341050-hnuogpqn	280	22	350	350	CD
cord-341050-hnuogpqn	280	23	-352	-352	NN
cord-341050-hnuogpqn	280	24	]	]	-RRB-
cord-341050-hnuogpqn	280	25	.	.	.
cord-341050-hnuogpqn	281	1	So	so	RB
cord-341050-hnuogpqn	281	2	far	far	RB
cord-341050-hnuogpqn	281	3	,	,	,
cord-341050-hnuogpqn	281	4	many	many	JJ
cord-341050-hnuogpqn	281	5	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	281	6	targeting	target	VBG
cord-341050-hnuogpqn	281	7	host	host	NN
cord-341050-hnuogpqn	281	8	proteins	protein	NNS
cord-341050-hnuogpqn	281	9	have	have	VBP
cord-341050-hnuogpqn	281	10	been	be	VBN
cord-341050-hnuogpqn	281	11	developed	develop	VBN
cord-341050-hnuogpqn	281	12	and	and	CC
cord-341050-hnuogpqn	281	13	tested	test	VBN
cord-341050-hnuogpqn	281	14	against	against	IN
cord-341050-hnuogpqn	281	15	WNV	WNV	NNP
cord-341050-hnuogpqn	281	16	and	and	CC
cord-341050-hnuogpqn	281	17	other	other	JJ
cord-341050-hnuogpqn	281	18	fl	fl	NNP
cord-341050-hnuogpqn	281	19	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	281	20	,	,	,
cord-341050-hnuogpqn	281	21	such	such	JJ
cord-341050-hnuogpqn	281	22	as	as	IN
cord-341050-hnuogpqn	281	23	HCV	HCV	NNP
cord-341050-hnuogpqn	281	24	.	.	.
cord-341050-hnuogpqn	282	1	Host	host	NN
cord-341050-hnuogpqn	282	2	cyclophilin	cyclophilin	NNP
cord-341050-hnuogpqn	282	3	,	,	,
cord-341050-hnuogpqn	282	4	a	a	DT
cord-341050-hnuogpqn	282	5	family	family	NN
cord-341050-hnuogpqn	282	6	of	of	IN
cord-341050-hnuogpqn	282	7	cellular	cellular	JJ
cord-341050-hnuogpqn	282	8	peptidyl	peptidyl	JJ
cord-341050-hnuogpqn	282	9	-	-	HYPH
cord-341050-hnuogpqn	282	10	prolyl	prolyl	JJ
cord-341050-hnuogpqn	282	11	isomerases	isomerase	NNS
cord-341050-hnuogpqn	282	12	,	,	,
cord-341050-hnuogpqn	282	13	may	may	MD
cord-341050-hnuogpqn	282	14	serve	serve	VB
cord-341050-hnuogpqn	282	15	as	as	IN
cord-341050-hnuogpqn	282	16	a	a	DT
cord-341050-hnuogpqn	282	17	component	component	NN
cord-341050-hnuogpqn	282	18	of	of	IN
cord-341050-hnuogpqn	282	19	fl	fl	NNP
cord-341050-hnuogpqn	282	20	avivirus	avivirus	NNP
cord-341050-hnuogpqn	282	21	replication	replication	NN
cord-341050-hnuogpqn	282	22	complex	complex	NN
cord-341050-hnuogpqn	282	23	and	and	CC
cord-341050-hnuogpqn	282	24	play	play	VB
cord-341050-hnuogpqn	282	25	a	a	DT
cord-341050-hnuogpqn	282	26	role	role	NN
cord-341050-hnuogpqn	282	27	in	in	IN
cord-341050-hnuogpqn	282	28	fl	fl	NNP
cord-341050-hnuogpqn	282	29	aviviral	aviviral	JJ
cord-341050-hnuogpqn	282	30	replication	replication	NN
cord-341050-hnuogpqn	282	31	.	.	.
cord-341050-hnuogpqn	283	1	Targeting	target	VBG
cord-341050-hnuogpqn	283	2	this	this	DT
cord-341050-hnuogpqn	283	3	enzyme	enzyme	NN
cord-341050-hnuogpqn	283	4	by	by	IN
cord-341050-hnuogpqn	283	5	cyclosporine	cyclosporine	NN
cord-341050-hnuogpqn	283	6	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	283	7	replication	replication	NN
cord-341050-hnuogpqn	283	8	of	of	IN
cord-341050-hnuogpqn	283	9	WNV	WNV	NNP
cord-341050-hnuogpqn	283	10	[	[	-LRB-
cord-341050-hnuogpqn	283	11	339	339	CD
cord-341050-hnuogpqn	283	12	]	]	-RRB-
cord-341050-hnuogpqn	283	13	.	.	.
cord-341050-hnuogpqn	284	1	Targeting	target	VBG
cord-341050-hnuogpqn	284	2	lipid	lipid	NN
cord-341050-hnuogpqn	284	3	signaling	signaling	NN
cord-341050-hnuogpqn	284	4	and	and	CC
cord-341050-hnuogpqn	284	5	metabolism	metabolism	NN
cord-341050-hnuogpqn	284	6	by	by	IN
cord-341050-hnuogpqn	284	7	a	a	DT
cord-341050-hnuogpqn	284	8	bioactive	bioactive	JJ
cord-341050-hnuogpqn	284	9	lipid	lipid	NN
cord-341050-hnuogpqn	284	10	signaling	signal	VBG
cord-341050-hnuogpqn	284	11	modulator	modulator	NN
cord-341050-hnuogpqn	284	12	4-hydroxyphenyl	4-hydroxyphenyl	CD
cord-341050-hnuogpqn	284	13	retinamide	retinamide	NN
cord-341050-hnuogpqn	284	14	(	(	-LRB-
cord-341050-hnuogpqn	284	15	4-HPR	4-hpr	CD
cord-341050-hnuogpqn	284	16	,	,	,
cord-341050-hnuogpqn	284	17	fenretinide	fenretinide	NNP
cord-341050-hnuogpqn	284	18	)	)	-RRB-
cord-341050-hnuogpqn	284	19	also	also	RB
cord-341050-hnuogpqn	284	20	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	284	21	replication	replication	NN
cord-341050-hnuogpqn	284	22	of	of	IN
cord-341050-hnuogpqn	284	23	WNV	WNV	NNP
cord-341050-hnuogpqn	284	24	and	and	CC
cord-341050-hnuogpqn	284	25	other	other	JJ
cord-341050-hnuogpqn	284	26	fl	fl	NNP
cord-341050-hnuogpqn	284	27	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	284	28	.	.	.
cord-341050-hnuogpqn	285	1	Similarly	similarly	RB
cord-341050-hnuogpqn	285	2	,	,	,
cord-341050-hnuogpqn	285	3	ribavirin	ribavirin	JJ
cord-341050-hnuogpqn	285	4	and	and	CC
cord-341050-hnuogpqn	285	5	mycophenolic	mycophenolic	NNP
cord-341050-hnuogpqn	285	6	acid	acid	NNP
cord-341050-hnuogpqn	285	7	target	target	NN
cord-341050-hnuogpqn	286	1	inosine	inosine	NNP
cord-341050-hnuogpqn	286	2	monophosphate	monophosphate	NN
cord-341050-hnuogpqn	286	3	dehydrogenase	dehydrogenase	NN
cord-341050-hnuogpqn	286	4	(	(	-LRB-
cord-341050-hnuogpqn	286	5	IMPDH	IMPDH	NNP
cord-341050-hnuogpqn	286	6	)	)	-RRB-
cord-341050-hnuogpqn	286	7	,	,	,
cord-341050-hnuogpqn	286	8	an	an	DT
cord-341050-hnuogpqn	286	9	enzyme	enzyme	NN
cord-341050-hnuogpqn	286	10	in	in	IN
cord-341050-hnuogpqn	286	11	purine	purine	NN
cord-341050-hnuogpqn	286	12	biosynthesis	biosynthesis	NN
cord-341050-hnuogpqn	286	13	,	,	,
cord-341050-hnuogpqn	286	14	and	and	CC
cord-341050-hnuogpqn	286	15	thereby	thereby	RB
cord-341050-hnuogpqn	286	16	inhibit	inhibit	VB
cord-341050-hnuogpqn	286	17	replication	replication	NN
cord-341050-hnuogpqn	286	18	of	of	IN
cord-341050-hnuogpqn	286	19	fl	fl	NNP
cord-341050-hnuogpqn	286	20	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	286	21	[	[	-LRB-
cord-341050-hnuogpqn	286	22	342	342	CD
cord-341050-hnuogpqn	286	23	,	,	,
cord-341050-hnuogpqn	286	24	343	343	CD
cord-341050-hnuogpqn	286	25	]	]	-RRB-
cord-341050-hnuogpqn	286	26	.	.	.
cord-341050-hnuogpqn	287	1	In	in	IN
cord-341050-hnuogpqn	287	2	addition	addition	NN
cord-341050-hnuogpqn	287	3	,	,	,
cord-341050-hnuogpqn	287	4	NITD-982	nitd-982	NN
cord-341050-hnuogpqn	287	5	and	and	CC
cord-341050-hnuogpqn	287	6	brequinar	brequinar	JJ
cord-341050-hnuogpqn	287	7	that	that	DT
cord-341050-hnuogpqn	287	8	block	block	VBP
cord-341050-hnuogpqn	287	9	pyrimidine	pyrimidine	NN
cord-341050-hnuogpqn	287	10	biosynthesis	biosynthesis	NN
cord-341050-hnuogpqn	287	11	also	also	RB
cord-341050-hnuogpqn	287	12	inhibit	inhibit	VBP
cord-341050-hnuogpqn	287	13	replication	replication	NN
cord-341050-hnuogpqn	287	14	of	of	IN
cord-341050-hnuogpqn	287	15	broad	broad	JJ
cord-341050-hnuogpqn	287	16	range	range	NN
cord-341050-hnuogpqn	287	17	of	of	IN
cord-341050-hnuogpqn	287	18	RNA	RNA	NNP
cord-341050-hnuogpqn	287	19	viruses	virus	NNS
cord-341050-hnuogpqn	287	20	,	,	,
cord-341050-hnuogpqn	287	21	including	include	VBG
cord-341050-hnuogpqn	287	22	WNV	WNV	NNP
cord-341050-hnuogpqn	287	23	and	and	CC
cord-341050-hnuogpqn	287	24	other	other	JJ
cord-341050-hnuogpqn	287	25	fl	fl	NNP
cord-341050-hnuogpqn	287	26	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	287	27	[	[	-LRB-
cord-341050-hnuogpqn	287	28	353	353	CD
cord-341050-hnuogpqn	287	29	,	,	,
cord-341050-hnuogpqn	287	30	354	354	CD
cord-341050-hnuogpqn	287	31	]	]	-RRB-
cord-341050-hnuogpqn	287	32	.	.	.
cord-341050-hnuogpqn	288	1	Besides	besides	IN
cord-341050-hnuogpqn	288	2	blocking	block	VBG
cord-341050-hnuogpqn	288	3	viral	viral	JJ
cord-341050-hnuogpqn	288	4	genome	genome	NN
cord-341050-hnuogpqn	288	5	replication	replication	NN
cord-341050-hnuogpqn	288	6	,	,	,
cord-341050-hnuogpqn	288	7	antiviral	antiviral	JJ
cord-341050-hnuogpqn	288	8	targeting	targeting	NN
cord-341050-hnuogpqn	288	9	of	of	IN
cord-341050-hnuogpqn	288	10	other	other	JJ
cord-341050-hnuogpqn	288	11	steps	step	NNS
cord-341050-hnuogpqn	288	12	,	,	,
cord-341050-hnuogpqn	288	13	such	such	JJ
cord-341050-hnuogpqn	288	14	as	as	IN
cord-341050-hnuogpqn	288	15	virus	virus	NN
cord-341050-hnuogpqn	288	16	maturation	maturation	NN
cord-341050-hnuogpqn	288	17	,	,	,
cord-341050-hnuogpqn	288	18	assembly	assembly	NN
cord-341050-hnuogpqn	288	19	,	,	,
cord-341050-hnuogpqn	288	20	and	and	CC
cord-341050-hnuogpqn	288	21	viral	viral	JJ
cord-341050-hnuogpqn	288	22	dissemination	dissemination	NN
cord-341050-hnuogpqn	288	23	into	into	IN
cord-341050-hnuogpqn	288	24	brain	brain	NN
cord-341050-hnuogpqn	288	25	has	have	VBZ
cord-341050-hnuogpqn	288	26	also	also	RB
cord-341050-hnuogpqn	288	27	been	be	VBN
cord-341050-hnuogpqn	288	28	suggested	suggest	VBN
cord-341050-hnuogpqn	288	29	and	and	CC
cord-341050-hnuogpqn	288	30	tested	test	VBN
cord-341050-hnuogpqn	288	31	against	against	IN
cord-341050-hnuogpqn	288	32	WNV	WNV	NNP
cord-341050-hnuogpqn	288	33	.	.	.
cord-341050-hnuogpqn	289	1	For	for	IN
cord-341050-hnuogpqn	289	2	instance	instance	NN
cord-341050-hnuogpqn	289	3	,	,	,
cord-341050-hnuogpqn	289	4	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	289	5	of	of	IN
cord-341050-hnuogpqn	289	6	alpha	alpha	NN
cord-341050-hnuogpqn	289	7	-	-	HYPH
cord-341050-hnuogpqn	289	8	glucosidase	glucosidase	NNP
cord-341050-hnuogpqn	289	9	I	I	NNP
cord-341050-hnuogpqn	289	10	and	and	CC
cord-341050-hnuogpqn	289	11	II	II	NNP
cord-341050-hnuogpqn	289	12	,	,	,
cord-341050-hnuogpqn	289	13	enzymes	enzyme	NNS
cord-341050-hnuogpqn	289	14	that	that	WDT
cord-341050-hnuogpqn	289	15	play	play	VBP
cord-341050-hnuogpqn	289	16	a	a	DT
cord-341050-hnuogpqn	289	17	role	role	NN
cord-341050-hnuogpqn	289	18	in	in	IN
cord-341050-hnuogpqn	289	19	processing	processing	NN
cord-341050-hnuogpqn	289	20	of	of	IN
cord-341050-hnuogpqn	289	21	N	n	NN
cord-341050-hnuogpqn	289	22	-	-	HYPH
cord-341050-hnuogpqn	289	23	linked	link	VBN
cord-341050-hnuogpqn	289	24	oligosaccharides	oligosaccharide	NNS
cord-341050-hnuogpqn	289	25	of	of	IN
cord-341050-hnuogpqn	289	26	the	the	DT
cord-341050-hnuogpqn	289	27	viral	viral	JJ
cord-341050-hnuogpqn	289	28	glycoproteins	glycoprotein	NNS
cord-341050-hnuogpqn	289	29	,	,	,
cord-341050-hnuogpqn	289	30	also	also	RB
cord-341050-hnuogpqn	289	31	inhibit	inhibit	VB
cord-341050-hnuogpqn	289	32	WNV	WNV	NNP
cord-341050-hnuogpqn	289	33	and	and	CC
cord-341050-hnuogpqn	289	34	other	other	JJ
cord-341050-hnuogpqn	289	35	fl	fl	NNP
cord-341050-hnuogpqn	289	36	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	289	37	[	[	-LRB-
cord-341050-hnuogpqn	289	38	205	205	CD
cord-341050-hnuogpqn	289	39	,	,	,
cord-341050-hnuogpqn	289	40	355	355	CD
cord-341050-hnuogpqn	289	41	]	]	-RRB-
cord-341050-hnuogpqn	289	42	.	.	.
cord-341050-hnuogpqn	290	1	Although	although	IN
cord-341050-hnuogpqn	290	2	the	the	DT
cord-341050-hnuogpqn	290	3	mechanism	mechanism	NN
cord-341050-hnuogpqn	290	4	by	by	IN
cord-341050-hnuogpqn	290	5	which	which	WDT
cord-341050-hnuogpqn	290	6	WNV	WNV	NNP
cord-341050-hnuogpqn	290	7	enters	enter	VBZ
cord-341050-hnuogpqn	290	8	the	the	DT
cord-341050-hnuogpqn	290	9	brain	brain	NN
cord-341050-hnuogpqn	290	10	is	be	VBZ
cord-341050-hnuogpqn	290	11	still	still	RB
cord-341050-hnuogpqn	290	12	poorly	poorly	RB
cord-341050-hnuogpqn	290	13	understood	understand	VBN
cord-341050-hnuogpqn	290	14	,	,	,
cord-341050-hnuogpqn	290	15	the	the	DT
cord-341050-hnuogpqn	290	16	two	two	CD
cord-341050-hnuogpqn	290	17	potential	potential	JJ
cord-341050-hnuogpqn	290	18	routes	route	NNS
cord-341050-hnuogpqn	290	19	include	include	VBP
cord-341050-hnuogpqn	290	20	axonal	axonal	JJ
cord-341050-hnuogpqn	290	21	retrograde	retrograde	JJ
cord-341050-hnuogpqn	290	22	transport	transport	NN
cord-341050-hnuogpqn	290	23	(	(	-LRB-
cord-341050-hnuogpqn	290	24	ART	art	NN
cord-341050-hnuogpqn	290	25	)	)	-RRB-
cord-341050-hnuogpqn	290	26	from	from	IN
cord-341050-hnuogpqn	290	27	the	the	DT
cord-341050-hnuogpqn	290	28	peripheral	peripheral	JJ
cord-341050-hnuogpqn	290	29	nervous	nervous	JJ
cord-341050-hnuogpqn	290	30	system	system	NN
cord-341050-hnuogpqn	290	31	and	and	CC
cord-341050-hnuogpqn	290	32	direct	direct	JJ
cord-341050-hnuogpqn	290	33	hematogenous	hematogenous	JJ
cord-341050-hnuogpqn	290	34	diffusion	diffusion	NN
cord-341050-hnuogpqn	290	35	via	via	IN
cord-341050-hnuogpqn	290	36	a	a	DT
cord-341050-hnuogpqn	290	37	breakdown	breakdown	NN
cord-341050-hnuogpqn	290	38	in	in	IN
cord-341050-hnuogpqn	290	39	the	the	DT
cord-341050-hnuogpqn	290	40	blood	blood	NN
cord-341050-hnuogpqn	290	41	-	-	HYPH
cord-341050-hnuogpqn	290	42	choroid	choroid	NN
cord-341050-hnuogpqn	290	43	plexus	plexus	NN
cord-341050-hnuogpqn	290	44	barrier	barrier	NN
cord-341050-hnuogpqn	290	45	[	[	-LRB-
cord-341050-hnuogpqn	290	46	356	356	CD
cord-341050-hnuogpqn	290	47	]	]	-RRB-
cord-341050-hnuogpqn	290	48	.	.	.
cord-341050-hnuogpqn	291	1	Nocodazole	Nocodazole	NNP
cord-341050-hnuogpqn	291	2	,	,	,
cord-341050-hnuogpqn	291	3	a	a	DT
cord-341050-hnuogpqn	291	4	microtubule	microtubule	JJ
cord-341050-hnuogpqn	291	5	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	291	6	that	that	WDT
cord-341050-hnuogpqn	291	7	blocks	block	VBZ
cord-341050-hnuogpqn	291	8	ART	art	NN
cord-341050-hnuogpqn	291	9	,	,	,
cord-341050-hnuogpqn	291	10	delays	delay	VBZ
cord-341050-hnuogpqn	291	11	WNV	WNV	NNP
cord-341050-hnuogpqn	291	12	entry	entry	NN
cord-341050-hnuogpqn	291	13	into	into	IN
cord-341050-hnuogpqn	291	14	brain	brain	NN
cord-341050-hnuogpqn	291	15	[	[	-LRB-
cord-341050-hnuogpqn	291	16	357	357	CD
cord-341050-hnuogpqn	291	17	]	]	-RRB-
cord-341050-hnuogpqn	291	18	.	.	.
cord-341050-hnuogpqn	292	1	The	the	DT
cord-341050-hnuogpqn	292	2	3′	3′	CD
cord-341050-hnuogpqn	292	3	or	or	CC
cord-341050-hnuogpqn	292	4	the	the	DT
cord-341050-hnuogpqn	292	5	5′	5′	CD
cord-341050-hnuogpqn	292	6	terminal	terminal	JJ
cord-341050-hnuogpqn	292	7	stem	stem	NN
cord-341050-hnuogpqn	292	8	-	-	HYPH
cord-341050-hnuogpqn	292	9	loop	loop	NN
cord-341050-hnuogpqn	292	10	in	in	IN
cord-341050-hnuogpqn	293	1	fl	fl	NNP
cord-341050-hnuogpqn	293	2	aviviral	aviviral	NNP
cord-341050-hnuogpqn	293	3	RNA	RNA	NNP
cord-341050-hnuogpqn	293	4	contains	contain	VBZ
cord-341050-hnuogpqn	293	5	essential	essential	JJ
cord-341050-hnuogpqn	293	6	cis	cis	NNP
cord-341050-hnuogpqn	293	7	-	-	HYPH
cord-341050-hnuogpqn	293	8	acting	act	VBG
cord-341050-hnuogpqn	293	9	elements	element	NNS
cord-341050-hnuogpqn	293	10	and	and	CC
cord-341050-hnuogpqn	293	11	plays	play	VBZ
cord-341050-hnuogpqn	293	12	important	important	JJ
cord-341050-hnuogpqn	293	13	roles	role	NNS
cord-341050-hnuogpqn	293	14	in	in	IN
cord-341050-hnuogpqn	293	15	viral	viral	JJ
cord-341050-hnuogpqn	293	16	replication	replication	NN
cord-341050-hnuogpqn	293	17	[	[	-LRB-
cord-341050-hnuogpqn	293	18	358	358	CD
cord-341050-hnuogpqn	293	19	,	,	,
cord-341050-hnuogpqn	293	20	359	359	CD
cord-341050-hnuogpqn	293	21	]	]	-RRB-
cord-341050-hnuogpqn	293	22	.	.	.
cord-341050-hnuogpqn	294	1	Interestingly	interestingly	RB
cord-341050-hnuogpqn	294	2	,	,	,
cord-341050-hnuogpqn	294	3	a	a	DT
cord-341050-hnuogpqn	294	4	range	range	NN
cord-341050-hnuogpqn	294	5	of	of	IN
cord-341050-hnuogpqn	294	6	cellular	cellular	JJ
cord-341050-hnuogpqn	294	7	proteins	protein	NNS
cord-341050-hnuogpqn	294	8	have	have	VBP
cord-341050-hnuogpqn	294	9	been	be	VBN
cord-341050-hnuogpqn	294	10	identifi	identifi	VBN
cord-341050-hnuogpqn	294	11	ed	ed	NN
cord-341050-hnuogpqn	294	12	to	to	TO
cord-341050-hnuogpqn	294	13	interact	interact	VB
cord-341050-hnuogpqn	294	14	with	with	IN
cord-341050-hnuogpqn	294	15	3′	3′	CD
cord-341050-hnuogpqn	294	16	stem	stem	NN
cord-341050-hnuogpqn	294	17	-	-	HYPH
cord-341050-hnuogpqn	294	18	loop	loop	NN
cord-341050-hnuogpqn	294	19	of	of	IN
cord-341050-hnuogpqn	294	20	fl	fl	NNP
cord-341050-hnuogpqn	294	21	aviviral	aviviral	NNP
cord-341050-hnuogpqn	294	22	RNAs	RNAs	NNPS
cord-341050-hnuogpqn	294	23	[	[	-LRB-
cord-341050-hnuogpqn	294	24	352	352	CD
cord-341050-hnuogpqn	294	25	,	,	,
cord-341050-hnuogpqn	294	26	359	359	CD
cord-341050-hnuogpqn	294	27	-362	-362	NN
cord-341050-hnuogpqn	294	28	]	]	-RRB-
cord-341050-hnuogpqn	294	29	,	,	,
cord-341050-hnuogpqn	294	30	suggesting	suggest	VBG
cord-341050-hnuogpqn	294	31	a	a	DT
cord-341050-hnuogpqn	294	32	potential	potential	JJ
cord-341050-hnuogpqn	294	33	strategy	strategy	NN
cord-341050-hnuogpqn	294	34	to	to	TO
cord-341050-hnuogpqn	294	35	design	design	VB
cord-341050-hnuogpqn	294	36	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	294	37	targeting	target	VBG
cord-341050-hnuogpqn	294	38	this	this	DT
cord-341050-hnuogpqn	294	39	virus	virus	NN
cord-341050-hnuogpqn	294	40	-	-	HYPH
cord-341050-hnuogpqn	294	41	host	host	NN
cord-341050-hnuogpqn	294	42	protein	protein	NN
cord-341050-hnuogpqn	294	43	interaction	interaction	NN
cord-341050-hnuogpqn	294	44	.	.	.
cord-341050-hnuogpqn	295	1	Targeting	target	VBG
cord-341050-hnuogpqn	295	2	host	host	NN
cord-341050-hnuogpqn	295	3	factors	factor	NNS
cord-341050-hnuogpqn	295	4	may	may	MD
cord-341050-hnuogpqn	295	5	raise	raise	VB
cord-341050-hnuogpqn	295	6	a	a	DT
cord-341050-hnuogpqn	295	7	higher	high	JJR
cord-341050-hnuogpqn	295	8	barrier	barrier	NN
cord-341050-hnuogpqn	295	9	to	to	IN
cord-341050-hnuogpqn	295	10	viral	viral	JJ
cord-341050-hnuogpqn	295	11	resistance	resistance	NN
cord-341050-hnuogpqn	295	12	emergence	emergence	NN
cord-341050-hnuogpqn	295	13	and	and	CC
cord-341050-hnuogpqn	295	14	provide	provide	VB
cord-341050-hnuogpqn	295	15	broad	broad	JJ
cord-341050-hnuogpqn	295	16	-	-	HYPH
cord-341050-hnuogpqn	295	17	spectrum	spectrum	NN
cord-341050-hnuogpqn	295	18	antiviral	antiviral	JJ
cord-341050-hnuogpqn	295	19	effects	effect	NNS
cord-341050-hnuogpqn	295	20	.	.	.
cord-341050-hnuogpqn	296	1	However	however	RB
cord-341050-hnuogpqn	296	2	,	,	,
cord-341050-hnuogpqn	296	3	current	current	JJ
cord-341050-hnuogpqn	296	4	understanding	understanding	NN
cord-341050-hnuogpqn	296	5	of	of	IN
cord-341050-hnuogpqn	296	6	virus	virus	NN
cord-341050-hnuogpqn	296	7	-	-	HYPH
cord-341050-hnuogpqn	296	8	host	host	NN
cord-341050-hnuogpqn	296	9	cell	cell	NN
cord-341050-hnuogpqn	296	10	interaction	interaction	NN
cord-341050-hnuogpqn	296	11	and	and	CC
cord-341050-hnuogpqn	296	12	research	research	NN
cord-341050-hnuogpqn	296	13	on	on	IN
cord-341050-hnuogpqn	296	14	targeting	target	VBG
cord-341050-hnuogpqn	296	15	of	of	IN
cord-341050-hnuogpqn	296	16	host	host	NN
cord-341050-hnuogpqn	296	17	factors	factor	NNS
cord-341050-hnuogpqn	296	18	to	to	TO
cord-341050-hnuogpqn	296	19	block	block	VB
cord-341050-hnuogpqn	296	20	viral	viral	JJ
cord-341050-hnuogpqn	296	21	infections	infection	NNS
cord-341050-hnuogpqn	296	22	are	be	VBP
cord-341050-hnuogpqn	296	23	still	still	RB
cord-341050-hnuogpqn	296	24	limited	limited	JJ
cord-341050-hnuogpqn	296	25	.	.	.
cord-341050-hnuogpqn	297	1	In	in	IN
cord-341050-hnuogpqn	297	2	addition	addition	NN
cord-341050-hnuogpqn	297	3	,	,	,
cord-341050-hnuogpqn	297	4	there	there	EX
cord-341050-hnuogpqn	297	5	are	be	VBP
cord-341050-hnuogpqn	297	6	some	some	DT
cord-341050-hnuogpqn	297	7	potential	potential	JJ
cord-341050-hnuogpqn	297	8	drawbacks	drawback	NNS
cord-341050-hnuogpqn	297	9	of	of	IN
cord-341050-hnuogpqn	297	10	this	this	DT
cord-341050-hnuogpqn	297	11	approach	approach	NN
cord-341050-hnuogpqn	297	12	,	,	,
cord-341050-hnuogpqn	297	13	including	include	VBG
cord-341050-hnuogpqn	297	14	undesirable	undesirable	JJ
cord-341050-hnuogpqn	297	15	drug	drug	NN
cord-341050-hnuogpqn	297	16	-	-	HYPH
cord-341050-hnuogpqn	297	17	induced	induce	VBN
cord-341050-hnuogpqn	297	18	side	side	NN
cord-341050-hnuogpqn	297	19	-	-	HYPH
cord-341050-hnuogpqn	297	20	effects	effect	NNS
cord-341050-hnuogpqn	297	21	and	and	CC
cord-341050-hnuogpqn	297	22	diffi	diffi	JJ
cord-341050-hnuogpqn	297	23	culties	cultie	NNS
cord-341050-hnuogpqn	297	24	for	for	IN
cord-341050-hnuogpqn	297	25	drug	drug	NN
cord-341050-hnuogpqn	297	26	delivery	delivery	NN
cord-341050-hnuogpqn	297	27	into	into	IN
cord-341050-hnuogpqn	297	28	brain	brain	NN
cord-341050-hnuogpqn	297	29	to	to	TO
cord-341050-hnuogpqn	297	30	control	control	VB
cord-341050-hnuogpqn	297	31	WNV	WNV	NNP
cord-341050-hnuogpqn	297	32	encephalitis	encephalitis	RB
cord-341050-hnuogpqn	297	33	.	.	.
cord-341050-hnuogpqn	298	1	Further	further	JJ
cord-341050-hnuogpqn	298	2	understanding	understanding	NN
cord-341050-hnuogpqn	298	3	of	of	IN
cord-341050-hnuogpqn	298	4	virus	virus	NN
cord-341050-hnuogpqn	298	5	-	-	HYPH
cord-341050-hnuogpqn	298	6	host	host	NN
cord-341050-hnuogpqn	298	7	interaction	interaction	NN
cord-341050-hnuogpqn	298	8	will	will	MD
cord-341050-hnuogpqn	298	9	facilitate	facilitate	VB
cord-341050-hnuogpqn	298	10	identifi	identifi	NNP
cord-341050-hnuogpqn	298	11	cation	cation	NN
cord-341050-hnuogpqn	298	12	of	of	IN
cord-341050-hnuogpqn	298	13	novel	novel	JJ
cord-341050-hnuogpqn	298	14	antiviral	antiviral	JJ
cord-341050-hnuogpqn	298	15	agents	agent	NNS
cord-341050-hnuogpqn	298	16	.	.	.
cord-341050-hnuogpqn	299	1	Development	development	NN
cord-341050-hnuogpqn	299	2	and	and	CC
cord-341050-hnuogpqn	299	3	testing	testing	NN
cord-341050-hnuogpqn	299	4	of	of	IN
cord-341050-hnuogpqn	299	5	various	various	JJ
cord-341050-hnuogpqn	299	6	methods	method	NNS
cord-341050-hnuogpqn	299	7	for	for	IN
cord-341050-hnuogpqn	299	8	treatment	treatment	NN
cord-341050-hnuogpqn	299	9	and	and	CC
cord-341050-hnuogpqn	299	10	prevention	prevention	NN
cord-341050-hnuogpqn	299	11	of	of	IN
cord-341050-hnuogpqn	299	12	WNV	WNV	NNP
cord-341050-hnuogpqn	299	13	infection	infection	NN
cord-341050-hnuogpqn	299	14	,	,	,
cord-341050-hnuogpqn	299	15	such	such	JJ
cord-341050-hnuogpqn	299	16	as	as	IN
cord-341050-hnuogpqn	299	17	protective	protective	JJ
cord-341050-hnuogpqn	299	18	vaccines	vaccine	NNS
cord-341050-hnuogpqn	299	19	,	,	,
cord-341050-hnuogpqn	299	20	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	299	21	antibodies	antibody	NNS
cord-341050-hnuogpqn	299	22	,	,	,
cord-341050-hnuogpqn	299	23	antiviral	antiviral	JJ
cord-341050-hnuogpqn	299	24	compounds	compound	NNS
cord-341050-hnuogpqn	299	25	,	,	,
cord-341050-hnuogpqn	299	26	peptides	peptide	NNS
cord-341050-hnuogpqn	299	27	,	,	,
cord-341050-hnuogpqn	299	28	and	and	CC
cord-341050-hnuogpqn	299	29	siRNA	siRNA	NNP
cord-341050-hnuogpqn	299	30	have	have	VBP
cord-341050-hnuogpqn	299	31	been	be	VBN
cord-341050-hnuogpqn	299	32	proposed	propose	VBN
cord-341050-hnuogpqn	299	33	and	and	CC
cord-341050-hnuogpqn	299	34	intensively	intensively	RB
cord-341050-hnuogpqn	299	35	studied	study	VBN
cord-341050-hnuogpqn	299	36	.	.	.
cord-341050-hnuogpqn	300	1	Although	although	IN
cord-341050-hnuogpqn	300	2	a	a	DT
cord-341050-hnuogpqn	300	3	number	number	NN
cord-341050-hnuogpqn	300	4	of	of	IN
cord-341050-hnuogpqn	300	5	WNV	WNV	NNP
cord-341050-hnuogpqn	300	6	veterinary	veterinary	JJ
cord-341050-hnuogpqn	300	7	vaccines	vaccine	NNS
cord-341050-hnuogpqn	300	8	have	have	VBP
cord-341050-hnuogpqn	300	9	already	already	RB
cord-341050-hnuogpqn	300	10	been	be	VBN
cord-341050-hnuogpqn	300	11	licensed	license	VBN
cord-341050-hnuogpqn	300	12	and	and	CC
cord-341050-hnuogpqn	300	13	are	be	VBP
cord-341050-hnuogpqn	300	14	in	in	IN
cord-341050-hnuogpqn	300	15	use	use	NN
cord-341050-hnuogpqn	300	16	for	for	IN
cord-341050-hnuogpqn	300	17	years	year	NNS
cord-341050-hnuogpqn	300	18	,	,	,
cord-341050-hnuogpqn	300	19	human	human	JJ
cord-341050-hnuogpqn	300	20	vaccine	vaccine	NN
cord-341050-hnuogpqn	300	21	candidates	candidate	NNS
cord-341050-hnuogpqn	300	22	are	be	VBP
cord-341050-hnuogpqn	300	23	still	still	RB
cord-341050-hnuogpqn	300	24	in	in	IN
cord-341050-hnuogpqn	300	25	various	various	JJ
cord-341050-hnuogpqn	300	26	stages	stage	NNS
cord-341050-hnuogpqn	300	27	of	of	IN
cord-341050-hnuogpqn	300	28	development	development	NN
cord-341050-hnuogpqn	300	29	and	and	CC
cord-341050-hnuogpqn	300	30	testing	testing	NN
cord-341050-hnuogpqn	300	31	.	.	.
cord-341050-hnuogpqn	301	1	Some	some	DT
cord-341050-hnuogpqn	301	2	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	301	3	antibodies	antibody	NNS
cord-341050-hnuogpqn	301	4	that	that	WDT
cord-341050-hnuogpqn	301	5	show	show	VBP
cord-341050-hnuogpqn	301	6	excellent	excellent	JJ
cord-341050-hnuogpqn	301	7	effi	effi	NNP
cord-341050-hnuogpqn	301	8	cacy	cacy	NN
cord-341050-hnuogpqn	301	9	in	in	IN
cord-341050-hnuogpqn	301	10	small	small	JJ
cord-341050-hnuogpqn	301	11	animal	animal	NN
cord-341050-hnuogpqn	301	12	models	model	NNS
cord-341050-hnuogpqn	301	13	and	and	CC
cord-341050-hnuogpqn	301	14	are	be	VBP
cord-341050-hnuogpqn	301	15	currently	currently	RB
cord-341050-hnuogpqn	301	16	being	be	VBG
cord-341050-hnuogpqn	301	17	tested	test	VBN
cord-341050-hnuogpqn	301	18	in	in	IN
cord-341050-hnuogpqn	301	19	clinical	clinical	JJ
cord-341050-hnuogpqn	301	20	trials	trial	NNS
cord-341050-hnuogpqn	301	21	represent	represent	VBP
cord-341050-hnuogpqn	301	22	a	a	DT
cord-341050-hnuogpqn	301	23	promising	promising	JJ
cord-341050-hnuogpqn	301	24	class	class	NN
cord-341050-hnuogpqn	301	25	of	of	IN
cord-341050-hnuogpqn	301	26	WNV	WNV	NNP
cord-341050-hnuogpqn	301	27	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	301	28	.	.	.
cord-341050-hnuogpqn	302	1	Recent	recent	JJ
cord-341050-hnuogpqn	302	2	technological	technological	JJ
cord-341050-hnuogpqn	302	3	advancement	advancement	NN
cord-341050-hnuogpqn	302	4	and	and	CC
cord-341050-hnuogpqn	302	5	increased	increase	VBN
cord-341050-hnuogpqn	302	6	understanding	understanding	NN
cord-341050-hnuogpqn	302	7	of	of	IN
cord-341050-hnuogpqn	302	8	the	the	DT
cord-341050-hnuogpqn	302	9	biology	biology	NN
cord-341050-hnuogpqn	302	10	of	of	IN
cord-341050-hnuogpqn	302	11	WNV	WNV	NNP
cord-341050-hnuogpqn	302	12	and	and	CC
cord-341050-hnuogpqn	302	13	other	other	JJ
cord-341050-hnuogpqn	302	14	fl	fl	NNP
cord-341050-hnuogpqn	302	15	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	302	16	along	along	IN
cord-341050-hnuogpqn	302	17	with	with	IN
cord-341050-hnuogpqn	302	18	structural	structural	JJ
cord-341050-hnuogpqn	302	19	/	/	SYM
cord-341050-hnuogpqn	302	20	functional	functional	JJ
cord-341050-hnuogpqn	302	21	characterization	characterization	NN
cord-341050-hnuogpqn	302	22	of	of	IN
cord-341050-hnuogpqn	302	23	viral	viral	JJ
cord-341050-hnuogpqn	302	24	proteins	protein	NNS
cord-341050-hnuogpqn	302	25	have	have	VBP
cord-341050-hnuogpqn	302	26	provided	provide	VBN
cord-341050-hnuogpqn	302	27	a	a	DT
cord-341050-hnuogpqn	302	28	solid	solid	JJ
cord-341050-hnuogpqn	302	29	foundation	foundation	NN
cord-341050-hnuogpqn	302	30	for	for	IN
cord-341050-hnuogpqn	302	31	the	the	DT
cord-341050-hnuogpqn	302	32	development	development	NN
cord-341050-hnuogpqn	302	33	of	of	IN
cord-341050-hnuogpqn	302	34	small	small	JJ
cord-341050-hnuogpqn	302	35	molecule	molecule	NN
cord-341050-hnuogpqn	302	36	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	302	37	as	as	IN
cord-341050-hnuogpqn	302	38	future	future	JJ
cord-341050-hnuogpqn	302	39	WNV	WNV	NNP
cord-341050-hnuogpqn	302	40	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	302	41	.	.	.
cord-341050-hnuogpqn	303	1	However	however	RB
cord-341050-hnuogpqn	303	2	,	,	,
cord-341050-hnuogpqn	303	3	efforts	effort	NNS
cord-341050-hnuogpqn	303	4	for	for	IN
cord-341050-hnuogpqn	303	5	development	development	NN
cord-341050-hnuogpqn	303	6	of	of	IN
cord-341050-hnuogpqn	303	7	an	an	DT
cord-341050-hnuogpqn	303	8	effective	effective	JJ
cord-341050-hnuogpqn	303	9	drug	drug	NN
cord-341050-hnuogpqn	303	10	for	for	IN
cord-341050-hnuogpqn	303	11	prevention	prevention	NN
cord-341050-hnuogpqn	303	12	or	or	CC
cord-341050-hnuogpqn	303	13	control	control	NN
cord-341050-hnuogpqn	303	14	of	of	IN
cord-341050-hnuogpqn	303	15	WNV	WNV	NNP
cord-341050-hnuogpqn	303	16	infection	infection	NN
cord-341050-hnuogpqn	303	17	in	in	IN
cord-341050-hnuogpqn	303	18	human	human	NN
cord-341050-hnuogpqn	303	19	still	still	RB
cord-341050-hnuogpqn	303	20	remain	remain	VBP
cord-341050-hnuogpqn	303	21	unsuccessful	unsuccessful	JJ
cord-341050-hnuogpqn	303	22	.	.	.
cord-341050-hnuogpqn	304	1	Some	some	DT
cord-341050-hnuogpqn	304	2	of	of	IN
cord-341050-hnuogpqn	304	3	the	the	DT
cord-341050-hnuogpqn	304	4	reasons	reason	NNS
cord-341050-hnuogpqn	304	5	include	include	VBP
cord-341050-hnuogpqn	304	6	a	a	DT
cord-341050-hnuogpqn	304	7	low	low	JJ
cord-341050-hnuogpqn	304	8	incidence	incidence	NN
cord-341050-hnuogpqn	304	9	of	of	IN
cord-341050-hnuogpqn	304	10	diseases	disease	NNS
cord-341050-hnuogpqn	304	11	,	,	,
cord-341050-hnuogpqn	304	12	low	low	JJ
cord-341050-hnuogpqn	304	13	commercial	commercial	JJ
cord-341050-hnuogpqn	304	14	interest	interest	NN
cord-341050-hnuogpqn	304	15	by	by	IN
cord-341050-hnuogpqn	304	16	pharmaceutical	pharmaceutical	JJ
cord-341050-hnuogpqn	304	17	companies	company	NNS
cord-341050-hnuogpqn	304	18	,	,	,
cord-341050-hnuogpqn	304	19	high	high	JJ
cord-341050-hnuogpqn	304	20	cost	cost	NN
cord-341050-hnuogpqn	304	21	of	of	IN
cord-341050-hnuogpqn	304	22	mass	mass	NN
cord-341050-hnuogpqn	304	23	vaccination	vaccination	NN
cord-341050-hnuogpqn	304	24	,	,	,
cord-341050-hnuogpqn	304	25	and	and	CC
cord-341050-hnuogpqn	304	26	diffi	diffi	NNP
cord-341050-hnuogpqn	304	27	culties	cultie	NNS
cord-341050-hnuogpqn	304	28	with	with	IN
cord-341050-hnuogpqn	304	29	running	run	VBG
cord-341050-hnuogpqn	304	30	clinical	clinical	JJ
cord-341050-hnuogpqn	304	31	trials	trial	NNS
cord-341050-hnuogpqn	304	32	due	due	JJ
cord-341050-hnuogpqn	304	33	to	to	IN
cord-341050-hnuogpqn	304	34	unpredictable	unpredictable	JJ
cord-341050-hnuogpqn	304	35	and	and	CC
cord-341050-hnuogpqn	304	36	sporadic	sporadic	JJ
cord-341050-hnuogpqn	304	37	nature	nature	NN
cord-341050-hnuogpqn	304	38	of	of	IN
cord-341050-hnuogpqn	304	39	WNV	WNV	NNP
cord-341050-hnuogpqn	304	40	outbreaks	outbreak	NNS
cord-341050-hnuogpqn	304	41	[	[	-LRB-
cord-341050-hnuogpqn	304	42	363	363	CD
cord-341050-hnuogpqn	304	43	,	,	,
cord-341050-hnuogpqn	304	44	364	364	CD
cord-341050-hnuogpqn	304	45	]	]	-RRB-
cord-341050-hnuogpqn	304	46	.	.	.
cord-341050-hnuogpqn	305	1	Another	another	DT
cord-341050-hnuogpqn	305	2	challenge	challenge	NN
cord-341050-hnuogpqn	305	3	for	for	IN
cord-341050-hnuogpqn	305	4	developing	develop	VBG
cord-341050-hnuogpqn	305	5	successful	successful	JJ
cord-341050-hnuogpqn	305	6	WNV	WNV	NNP
cord-341050-hnuogpqn	305	7	therapeutics	therapeutic	NNS
cord-341050-hnuogpqn	305	8	is	be	VBZ
cord-341050-hnuogpqn	305	9	to	to	TO
cord-341050-hnuogpqn	305	10	ensure	ensure	VB
cord-341050-hnuogpqn	305	11	safety	safety	NN
cord-341050-hnuogpqn	305	12	and	and	CC
cord-341050-hnuogpqn	305	13	effi	effi	NNP
cord-341050-hnuogpqn	305	14	cacy	cacy	NNP
cord-341050-hnuogpqn	305	15	in	in	IN
cord-341050-hnuogpqn	305	16	target	target	NN
cord-341050-hnuogpqn	305	17	populations	population	NNS
cord-341050-hnuogpqn	305	18	that	that	WDT
cord-341050-hnuogpqn	305	19	mostly	mostly	RB
cord-341050-hnuogpqn	305	20	include	include	VBP
cord-341050-hnuogpqn	305	21	children	child	NNS
cord-341050-hnuogpqn	305	22	,	,	,
cord-341050-hnuogpqn	305	23	elderly	elderly	JJ
cord-341050-hnuogpqn	305	24	,	,	,
cord-341050-hnuogpqn	305	25	and	and	CC
cord-341050-hnuogpqn	305	26	immune	immune	NN
cord-341050-hnuogpqn	305	27	-	-	HYPH
cord-341050-hnuogpqn	305	28	compromised	compromise	VBN
cord-341050-hnuogpqn	305	29	individuals	individual	NNS
cord-341050-hnuogpqn	305	30	.	.	.
cord-341050-hnuogpqn	306	1	Despite	despite	IN
cord-341050-hnuogpqn	306	2	all	all	PDT
cord-341050-hnuogpqn	306	3	these	these	DT
cord-341050-hnuogpqn	306	4	diffi	diffi	JJ
cord-341050-hnuogpqn	306	5	culties	cultie	NNS
cord-341050-hnuogpqn	306	6	,	,	,
cord-341050-hnuogpqn	306	7	the	the	DT
cord-341050-hnuogpqn	306	8	quest	quest	NN
cord-341050-hnuogpqn	306	9	for	for	IN
cord-341050-hnuogpqn	306	10	development	development	NN
cord-341050-hnuogpqn	306	11	of	of	IN
cord-341050-hnuogpqn	306	12	effective	effective	JJ
cord-341050-hnuogpqn	306	13	treatment	treatment	NN
cord-341050-hnuogpqn	306	14	and	and	CC
cord-341050-hnuogpqn	306	15	prevention	prevention	NN
cord-341050-hnuogpqn	306	16	methods	method	NNS
cord-341050-hnuogpqn	306	17	against	against	IN
cord-341050-hnuogpqn	306	18	WNV	WNV	NNP
cord-341050-hnuogpqn	306	19	infection	infection	NN
cord-341050-hnuogpqn	306	20	are	be	VBP
cord-341050-hnuogpqn	306	21	likely	likely	JJ
cord-341050-hnuogpqn	306	22	to	to	TO
cord-341050-hnuogpqn	306	23	be	be	VB
cord-341050-hnuogpqn	306	24	facilitated	facilitate	VBN
cord-341050-hnuogpqn	306	25	by	by	IN
cord-341050-hnuogpqn	306	26	recent	recent	JJ
cord-341050-hnuogpqn	306	27	technological	technological	JJ
cord-341050-hnuogpqn	306	28	advancement	advancement	NN
cord-341050-hnuogpqn	306	29	and	and	CC
cord-341050-hnuogpqn	306	30	should	should	MD
cord-341050-hnuogpqn	306	31	continue	continue	VB
cord-341050-hnuogpqn	306	32	to	to	TO
cord-341050-hnuogpqn	306	33	meet	meet	VB
cord-341050-hnuogpqn	306	34	the	the	DT
cord-341050-hnuogpqn	306	35	public	public	JJ
cord-341050-hnuogpqn	306	36	health	health	NN
cord-341050-hnuogpqn	306	37	needs	need	NNS
cord-341050-hnuogpqn	306	38	.	.	.
cord-341050-hnuogpqn	306	39	 	 	_SP
cord-341050-hnuogpqn	307	1	dengue	dengue	NN
cord-341050-hnuogpqn	307	2	virus	virus	NN
cord-341050-hnuogpqn	307	3	NS5	NS5	NNP
cord-341050-hnuogpqn	307	4	RNA	RNA	NNP
cord-341050-hnuogpqn	307	5	capping	cap	VBG
cord-341050-hnuogpqn	307	6	enzyme	enzyme	NN
cord-341050-hnuogpqn	308	1	West	West	NNP
cord-341050-hnuogpqn	308	2	Nile	Nile	NNP
cord-341050-hnuogpqn	308	3	virus	virus	NN
cord-341050-hnuogpqn	308	4	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	308	5	domain	domain	NN
cord-341050-hnuogpqn	308	6	interacts	interact	VBZ
cord-341050-hnuogpqn	308	7	with	with	IN
cord-341050-hnuogpqn	308	8	protein	protein	NN
cord-341050-hnuogpqn	308	9	kinase	kinase	NN
cord-341050-hnuogpqn	308	10	G	G	NNP
cord-341050-hnuogpqn	308	11	A	a	DT
cord-341050-hnuogpqn	308	12	single	single	JJ
cord-341050-hnuogpqn	308	13	amino	amino	NN
cord-341050-hnuogpqn	308	14	acid	acid	NN
cord-341050-hnuogpqn	308	15	in	in	IN
cord-341050-hnuogpqn	308	16	nonstructural	nonstructural	JJ
cord-341050-hnuogpqn	308	17	protein	protein	NN
cord-341050-hnuogpqn	309	1	NS4B	NS4B	NNP
cord-341050-hnuogpqn	309	2	confers	confer	VBZ
cord-341050-hnuogpqn	309	3	virulence	virulence	NN
cord-341050-hnuogpqn	309	4	to	to	IN
cord-341050-hnuogpqn	309	5	dengue	dengue	NN
cord-341050-hnuogpqn	309	6	virus	virus	NN
cord-341050-hnuogpqn	309	7	in	in	IN
cord-341050-hnuogpqn	309	8	AG129	AG129	NNP
cord-341050-hnuogpqn	309	9	mice	mouse	NNS
cord-341050-hnuogpqn	309	10	through	through	IN
cord-341050-hnuogpqn	309	11	enhancement	enhancement	NN
cord-341050-hnuogpqn	309	12	of	of	IN
cord-341050-hnuogpqn	309	13	viral	viral	JJ
cord-341050-hnuogpqn	309	14	RNA	RNA	NNP
cord-341050-hnuogpqn	309	15	synthesis	synthesis	NN
cord-341050-hnuogpqn	310	1	A	a	DT
cord-341050-hnuogpqn	310	2	single	single	JJ
cord-341050-hnuogpqn	310	3	amino	amino	NN
cord-341050-hnuogpqn	310	4	acid	acid	NN
cord-341050-hnuogpqn	310	5	substitution	substitution	NN
cord-341050-hnuogpqn	310	6	in	in	IN
cord-341050-hnuogpqn	310	7	the	the	DT
cord-341050-hnuogpqn	310	8	central	central	JJ
cord-341050-hnuogpqn	310	9	portion	portion	NN
cord-341050-hnuogpqn	310	10	of	of	IN
cord-341050-hnuogpqn	310	11	the	the	DT
cord-341050-hnuogpqn	310	12	West	West	NNP
cord-341050-hnuogpqn	310	13	Nile	Nile	NNP
cord-341050-hnuogpqn	310	14	virus	virus	NN
cord-341050-hnuogpqn	310	15	NS4B	NS4B	NNP
cord-341050-hnuogpqn	310	16	protein	protein	NN
cord-341050-hnuogpqn	310	17	confers	confer	VBZ
cord-341050-hnuogpqn	310	18	a	a	DT
cord-341050-hnuogpqn	310	19	highly	highly	RB
cord-341050-hnuogpqn	310	20	attenuated	attenuated	JJ
cord-341050-hnuogpqn	310	21	phenotype	phenotype	NN
cord-341050-hnuogpqn	310	22	in	in	IN
cord-341050-hnuogpqn	310	23	mice	mouse	NNS
cord-341050-hnuogpqn	310	24	Inhibition	inhibition	NN
cord-341050-hnuogpqn	310	25	of	of	IN
cord-341050-hnuogpqn	310	26	dengue	dengue	NN
cord-341050-hnuogpqn	310	27	virus	virus	NN
cord-341050-hnuogpqn	310	28	by	by	IN
cord-341050-hnuogpqn	310	29	targeting	target	VBG
cord-341050-hnuogpqn	310	30	viral	viral	JJ
cord-341050-hnuogpqn	310	31	NS4B	NS4B	NNP
cord-341050-hnuogpqn	310	32	protein	protein	NN
cord-341050-hnuogpqn	310	33	Chemical	Chemical	NNP
cord-341050-hnuogpqn	310	34	genetics	genetics	NN
cord-341050-hnuogpqn	310	35	strategy	strategy	NN
cord-341050-hnuogpqn	310	36	identifi	identifi	NNP
cord-341050-hnuogpqn	310	37	es	es	NNP
cord-341050-hnuogpqn	310	38	an	an	DT
cord-341050-hnuogpqn	310	39	HCV	HCV	NNP
cord-341050-hnuogpqn	311	1	NS5A	NS5A	NNP
cord-341050-hnuogpqn	311	2	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	311	3	with	with	IN
cord-341050-hnuogpqn	311	4	a	a	DT
cord-341050-hnuogpqn	311	5	potent	potent	JJ
cord-341050-hnuogpqn	311	6	clinical	clinical	JJ
cord-341050-hnuogpqn	311	7	effect	effect	NN
cord-341050-hnuogpqn	312	1	B	b	NN
cord-341050-hnuogpqn	312	2	cells	cell	NNS
cord-341050-hnuogpqn	312	3	and	and	CC
cord-341050-hnuogpqn	312	4	antibody	antibody	NN
cord-341050-hnuogpqn	312	5	play	play	VBP
cord-341050-hnuogpqn	312	6	critical	critical	JJ
cord-341050-hnuogpqn	312	7	roles	role	NNS
cord-341050-hnuogpqn	312	8	in	in	IN
cord-341050-hnuogpqn	312	9	the	the	DT
cord-341050-hnuogpqn	312	10	immediate	immediate	JJ
cord-341050-hnuogpqn	312	11	defense	defense	NN
cord-341050-hnuogpqn	312	12	of	of	IN
cord-341050-hnuogpqn	312	13	disseminated	disseminate	VBN
cord-341050-hnuogpqn	312	14	infection	infection	NN
cord-341050-hnuogpqn	312	15	by	by	IN
cord-341050-hnuogpqn	312	16	West	West	NNP
cord-341050-hnuogpqn	312	17	Nile	Nile	NNP
cord-341050-hnuogpqn	312	18	encephalitis	encephalitis	NN
cord-341050-hnuogpqn	312	19	virus	virus	NN
cord-341050-hnuogpqn	313	1	A	a	DT
cord-341050-hnuogpqn	313	2	critical	critical	JJ
cord-341050-hnuogpqn	313	3	role	role	NN
cord-341050-hnuogpqn	313	4	for	for	IN
cord-341050-hnuogpqn	313	5	induced	induce	VBN
cord-341050-hnuogpqn	313	6	IgM	IgM	NNP
cord-341050-hnuogpqn	313	7	in	in	IN
cord-341050-hnuogpqn	313	8	the	the	DT
cord-341050-hnuogpqn	313	9	protection	protection	NN
cord-341050-hnuogpqn	313	10	against	against	IN
cord-341050-hnuogpqn	313	11	West	West	NNP
cord-341050-hnuogpqn	313	12	Nile	Nile	NNP
cord-341050-hnuogpqn	313	13	virus	virus	NN
cord-341050-hnuogpqn	313	14	infection	infection	NN
cord-341050-hnuogpqn	314	1	The	the	DT
cord-341050-hnuogpqn	314	2	memory	memory	NN
cord-341050-hnuogpqn	314	3	T	T	NNP
cord-341050-hnuogpqn	314	4	cell	cell	NN
cord-341050-hnuogpqn	314	5	response	response	NN
cord-341050-hnuogpqn	314	6	to	to	IN
cord-341050-hnuogpqn	314	7	West	West	NNP
cord-341050-hnuogpqn	314	8	Nile	Nile	NNP
cord-341050-hnuogpqn	314	9	virus	virus	NN
cord-341050-hnuogpqn	314	10	in	in	IN
cord-341050-hnuogpqn	314	11	symptomatic	symptomatic	JJ
cord-341050-hnuogpqn	314	12	humans	human	NNS
cord-341050-hnuogpqn	314	13	following	follow	VBG
cord-341050-hnuogpqn	314	14	natural	natural	JJ
cord-341050-hnuogpqn	314	15	infection	infection	NN
cord-341050-hnuogpqn	314	16	is	be	VBZ
cord-341050-hnuogpqn	314	17	not	not	RB
cord-341050-hnuogpqn	314	18	infl	infl	NN
cord-341050-hnuogpqn	314	19	uenced	uence	VBN
cord-341050-hnuogpqn	314	20	by	by	IN
cord-341050-hnuogpqn	314	21	age	age	NN
cord-341050-hnuogpqn	314	22	and	and	CC
cord-341050-hnuogpqn	314	23	is	be	VBZ
cord-341050-hnuogpqn	314	24	dominated	dominate	VBN
cord-341050-hnuogpqn	314	25	by	by	IN
cord-341050-hnuogpqn	314	26	a	a	DT
cord-341050-hnuogpqn	314	27	restricted	restricted	JJ
cord-341050-hnuogpqn	314	28	set	set	NN
cord-341050-hnuogpqn	314	29	of	of	IN
cord-341050-hnuogpqn	314	30	CD8	CD8	NNP
cord-341050-hnuogpqn	314	31	+	+	CC
cord-341050-hnuogpqn	314	32	T	T	NNP
cord-341050-hnuogpqn	314	33	cell	cell	NN
cord-341050-hnuogpqn	314	34	epitopes	epitope	NNS
cord-341050-hnuogpqn	315	1	Comprehensive	comprehensive	JJ
cord-341050-hnuogpqn	315	2	mapping	mapping	NN
cord-341050-hnuogpqn	315	3	of	of	IN
cord-341050-hnuogpqn	315	4	West	West	NNP
cord-341050-hnuogpqn	315	5	Nile	Nile	NNP
cord-341050-hnuogpqn	315	6	virus	virus	NN
cord-341050-hnuogpqn	315	7	(	(	-LRB-
cord-341050-hnuogpqn	315	8	WNV)-and	wnv)-and	PRP$
cord-341050-hnuogpqn	315	9	Japanese	japanese	JJ
cord-341050-hnuogpqn	315	10	encephalitis	encephalitis	RB
cord-341050-hnuogpqn	315	11	virus	virus	NN
cord-341050-hnuogpqn	315	12	serocomplex	serocomplex	NN
cord-341050-hnuogpqn	315	13	-	-	HYPH
cord-341050-hnuogpqn	315	14	specifi	specifi	NNP
cord-341050-hnuogpqn	315	15	c	c	NN
cord-341050-hnuogpqn	315	16	linear	linear	NNP
cord-341050-hnuogpqn	315	17	B	B	NNP
cord-341050-hnuogpqn	315	18	-	-	HYPH
cord-341050-hnuogpqn	315	19	cell	cell	NN
cord-341050-hnuogpqn	315	20	epitopes	epitope	NNS
cord-341050-hnuogpqn	315	21	from	from	IN
cord-341050-hnuogpqn	315	22	WNV	WNV	NNP
cord-341050-hnuogpqn	315	23	non	non	JJ
cord-341050-hnuogpqn	315	24	-	-	JJ
cord-341050-hnuogpqn	315	25	structural	structural	JJ
cord-341050-hnuogpqn	315	26	protein	protein	NN
cord-341050-hnuogpqn	315	27	1	1	CD
cord-341050-hnuogpqn	315	28	Identifi	Identifi	NNP
cord-341050-hnuogpqn	315	29	cation	cation	NN
cord-341050-hnuogpqn	315	30	of	of	IN
cord-341050-hnuogpqn	315	31	two	two	CD
cord-341050-hnuogpqn	315	32	linear	linear	JJ
cord-341050-hnuogpqn	315	33	B	b	NN
cord-341050-hnuogpqn	315	34	-	-	HYPH
cord-341050-hnuogpqn	315	35	cell	cell	NN
cord-341050-hnuogpqn	315	36	epitopes	epitope	NNS
cord-341050-hnuogpqn	315	37	from	from	IN
cord-341050-hnuogpqn	315	38	West	West	NNP
cord-341050-hnuogpqn	315	39	Nile	Nile	NNP
cord-341050-hnuogpqn	315	40	virus	virus	NN
cord-341050-hnuogpqn	315	41	NS1	ns1	NN
cord-341050-hnuogpqn	315	42	by	by	IN
cord-341050-hnuogpqn	315	43	screening	screen	VBG
cord-341050-hnuogpqn	315	44	a	a	DT
cord-341050-hnuogpqn	315	45	phage	phage	NN
cord-341050-hnuogpqn	315	46	-	-	HYPH
cord-341050-hnuogpqn	315	47	displayed	display	VBN
cord-341050-hnuogpqn	315	48	random	random	JJ
cord-341050-hnuogpqn	315	49	peptide	peptide	NN
cord-341050-hnuogpqn	315	50	library	library	NN
cord-341050-hnuogpqn	315	51	Mapping	mapping	NN
cord-341050-hnuogpqn	315	52	and	and	CC
cord-341050-hnuogpqn	315	53	analysis	analysis	NN
cord-341050-hnuogpqn	315	54	of	of	IN
cord-341050-hnuogpqn	315	55	West	West	NNP
cord-341050-hnuogpqn	315	56	Nile	Nile	NNP
cord-341050-hnuogpqn	315	57	virus	virus	NN
cord-341050-hnuogpqn	315	58	-	-	HYPH
cord-341050-hnuogpqn	315	59	specifi	specifi	VBN
cord-341050-hnuogpqn	315	60	c	c	NN
cord-341050-hnuogpqn	315	61	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	315	62	antibodies	antibody	NNS
cord-341050-hnuogpqn	315	63	:	:	:
cord-341050-hnuogpqn	315	64	prospects	prospect	NNS
cord-341050-hnuogpqn	315	65	for	for	IN
cord-341050-hnuogpqn	315	66	vaccine	vaccine	NN
cord-341050-hnuogpqn	315	67	development	development	NN
cord-341050-hnuogpqn	315	68	Fusion	Fusion	NNP
cord-341050-hnuogpqn	315	69	loop	loop	NN
cord-341050-hnuogpqn	315	70	peptide	peptide	NN
cord-341050-hnuogpqn	315	71	of	of	IN
cord-341050-hnuogpqn	315	72	the	the	DT
cord-341050-hnuogpqn	315	73	West	West	NNP
cord-341050-hnuogpqn	315	74	Nile	Nile	NNP
cord-341050-hnuogpqn	315	75	virus	virus	NN
cord-341050-hnuogpqn	315	76	envelope	envelope	NN
cord-341050-hnuogpqn	315	77	protein	protein	NN
cord-341050-hnuogpqn	315	78	is	be	VBZ
cord-341050-hnuogpqn	315	79	essential	essential	JJ
cord-341050-hnuogpqn	315	80	for	for	IN
cord-341050-hnuogpqn	315	81	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	315	82	and	and	CC
cord-341050-hnuogpqn	315	83	is	be	VBZ
cord-341050-hnuogpqn	315	84	recognized	recognize	VBN
cord-341050-hnuogpqn	315	85	by	by	IN
cord-341050-hnuogpqn	315	86	a	a	DT
cord-341050-hnuogpqn	315	87	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	315	88	cross	cross	JJ
cord-341050-hnuogpqn	315	89	-	-	JJ
cord-341050-hnuogpqn	315	90	reactive	reactive	JJ
cord-341050-hnuogpqn	315	91	human	human	JJ
cord-341050-hnuogpqn	315	92	monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	315	93	antibody	antibody	NN
cord-341050-hnuogpqn	315	94	Role	role	NN
cord-341050-hnuogpqn	315	95	of	of	IN
cord-341050-hnuogpqn	315	96	IFN	IFN	NNP
cord-341050-hnuogpqn	315	97	-	-	HYPH
cord-341050-hnuogpqn	315	98	gamma	gamma	NN
cord-341050-hnuogpqn	315	99	in	in	IN
cord-341050-hnuogpqn	315	100	an	an	DT
cord-341050-hnuogpqn	315	101	experimental	experimental	JJ
cord-341050-hnuogpqn	315	102	murine	murine	NN
cord-341050-hnuogpqn	315	103	model	model	NN
cord-341050-hnuogpqn	315	104	of	of	IN
cord-341050-hnuogpqn	315	105	West	West	NNP
cord-341050-hnuogpqn	315	106	Nile	Nile	NNP
cord-341050-hnuogpqn	315	107	virus	virus	NN
cord-341050-hnuogpqn	315	108	-	-	HYPH
cord-341050-hnuogpqn	315	109	induced	induce	VBN
cord-341050-hnuogpqn	315	110	seizures	seizure	NNS
cord-341050-hnuogpqn	315	111	Role	role	NN
cord-341050-hnuogpqn	315	112	of	of	IN
cord-341050-hnuogpqn	315	113	CD8	CD8	NNP
cord-341050-hnuogpqn	315	114	+	+	CC
cord-341050-hnuogpqn	315	115	T	T	NNP
cord-341050-hnuogpqn	315	116	cells	cell	NNS
cord-341050-hnuogpqn	315	117	in	in	IN
cord-341050-hnuogpqn	315	118	control	control	NN
cord-341050-hnuogpqn	315	119	of	of	IN
cord-341050-hnuogpqn	315	120	West	West	NNP
cord-341050-hnuogpqn	315	121	Nile	Nile	NNP
cord-341050-hnuogpqn	315	122	virus	virus	NN
cord-341050-hnuogpqn	315	123	infection	infection	NN
cord-341050-hnuogpqn	316	1	The	the	DT
cord-341050-hnuogpqn	316	2	relative	relative	JJ
cord-341050-hnuogpqn	316	3	contribution	contribution	NN
cord-341050-hnuogpqn	316	4	of	of	IN
cord-341050-hnuogpqn	316	5	antibody	antibody	NN
cord-341050-hnuogpqn	316	6	and	and	CC
cord-341050-hnuogpqn	316	7	CD8	CD8	NNP
cord-341050-hnuogpqn	316	8	+	+	CC
cord-341050-hnuogpqn	316	9	T	T	NNP
cord-341050-hnuogpqn	316	10	cells	cell	NNS
cord-341050-hnuogpqn	316	11	to	to	IN
cord-341050-hnuogpqn	316	12	vaccine	vaccine	NN
cord-341050-hnuogpqn	316	13	immunity	immunity	NN
cord-341050-hnuogpqn	316	14	against	against	IN
cord-341050-hnuogpqn	316	15	West	West	NNP
cord-341050-hnuogpqn	316	16	Nile	Nile	NNP
cord-341050-hnuogpqn	316	17	encephalitis	encephalitis	NN
cord-341050-hnuogpqn	316	18	virus	virus	NN
cord-341050-hnuogpqn	317	1	Gamma	gamma	NN
cord-341050-hnuogpqn	317	2	interferon	interferon	NN
cord-341050-hnuogpqn	317	3	plays	play	VBZ
cord-341050-hnuogpqn	317	4	a	a	DT
cord-341050-hnuogpqn	317	5	crucial	crucial	JJ
cord-341050-hnuogpqn	317	6	early	early	JJ
cord-341050-hnuogpqn	317	7	antiviral	antiviral	JJ
cord-341050-hnuogpqn	317	8	role	role	NN
cord-341050-hnuogpqn	317	9	in	in	IN
cord-341050-hnuogpqn	317	10	protection	protection	NN
cord-341050-hnuogpqn	317	11	against	against	IN
cord-341050-hnuogpqn	317	12	West	West	NNP
cord-341050-hnuogpqn	317	13	Nile	Nile	NNP
cord-341050-hnuogpqn	317	14	virus	virus	NN
cord-341050-hnuogpqn	317	15	infection	infection	NN
cord-341050-hnuogpqn	317	16	Pattern	Pattern	NNP
cord-341050-hnuogpqn	317	17	recognition	recognition	NN
cord-341050-hnuogpqn	317	18	receptor	receptor	NN
cord-341050-hnuogpqn	317	19	MDA5	MDA5	NNP
cord-341050-hnuogpqn	317	20	modulates	modulate	VBZ
cord-341050-hnuogpqn	317	21	CD8	CD8	NNP
cord-341050-hnuogpqn	317	22	+	+	CC
cord-341050-hnuogpqn	317	23	T	T	NNP
cord-341050-hnuogpqn	317	24	cell	cell	NN
cord-341050-hnuogpqn	317	25	-	-	HYPH
cord-341050-hnuogpqn	317	26	dependent	dependent	JJ
cord-341050-hnuogpqn	317	27	clearance	clearance	NN
cord-341050-hnuogpqn	317	28	of	of	IN
cord-341050-hnuogpqn	317	29	West	West	NNP
cord-341050-hnuogpqn	317	30	Nile	Nile	NNP
cord-341050-hnuogpqn	317	31	virus	virus	NN
cord-341050-hnuogpqn	317	32	from	from	IN
cord-341050-hnuogpqn	317	33	the	the	DT
cord-341050-hnuogpqn	317	34	central	central	JJ
cord-341050-hnuogpqn	317	35	nervous	nervous	JJ
cord-341050-hnuogpqn	317	36	system	system	NN
cord-341050-hnuogpqn	317	37	Attenuation	attenuation	NN
cord-341050-hnuogpqn	317	38	and	and	CC
cord-341050-hnuogpqn	317	39	immunogenicity	immunogenicity	NN
cord-341050-hnuogpqn	317	40	in	in	IN
cord-341050-hnuogpqn	317	41	humans	human	NNS
cord-341050-hnuogpqn	317	42	of	of	IN
cord-341050-hnuogpqn	317	43	a	a	DT
cord-341050-hnuogpqn	317	44	live	live	JJ
cord-341050-hnuogpqn	317	45	dengue	dengue	NN
cord-341050-hnuogpqn	317	46	virus	virus	NN
cord-341050-hnuogpqn	317	47	type-4	type-4	NNP
cord-341050-hnuogpqn	317	48	vaccine	vaccine	NN
cord-341050-hnuogpqn	317	49	candidate	candidate	NN
cord-341050-hnuogpqn	317	50	with	with	IN
cord-341050-hnuogpqn	317	51	a	a	DT
cord-341050-hnuogpqn	317	52	30	30	CD
cord-341050-hnuogpqn	317	53	nucleotide	nucleotide	JJ
cord-341050-hnuogpqn	317	54	deletion	deletion	NN
cord-341050-hnuogpqn	317	55	in	in	IN
cord-341050-hnuogpqn	317	56	its	-PRON-	PRP$
cord-341050-hnuogpqn	317	57	3′-untranslated	3′-untranslated	CD
cord-341050-hnuogpqn	317	58	region	region	NN
cord-341050-hnuogpqn	318	1	The	the	DT
cord-341050-hnuogpqn	318	2	live	live	JJ
cord-341050-hnuogpqn	318	3	attenuated	attenuated	JJ
cord-341050-hnuogpqn	318	4	chimeric	chimeric	JJ
cord-341050-hnuogpqn	318	5	vaccine	vaccine	NN
cord-341050-hnuogpqn	318	6	rWN/	rWN/	NNP
cord-341050-hnuogpqn	319	1	DEN4Delta30	DEN4Delta30	NNP
cord-341050-hnuogpqn	319	2	is	be	VBZ
cord-341050-hnuogpqn	319	3	well	well	RB
cord-341050-hnuogpqn	319	4	-	-	HYPH
cord-341050-hnuogpqn	319	5	tolerated	tolerate	VBN
cord-341050-hnuogpqn	319	6	and	and	CC
cord-341050-hnuogpqn	319	7	immunogenic	immunogenic	JJ
cord-341050-hnuogpqn	319	8	in	in	IN
cord-341050-hnuogpqn	319	9	healthy	healthy	JJ
cord-341050-hnuogpqn	319	10	fl	fl	NNP
cord-341050-hnuogpqn	319	11	avivirus	avivirus	JJ
cord-341050-hnuogpqn	319	12	-	-	HYPH
cord-341050-hnuogpqn	319	13	naive	naive	JJ
cord-341050-hnuogpqn	319	14	adult	adult	NN
cord-341050-hnuogpqn	319	15	volunteers	volunteer	NNS
cord-341050-hnuogpqn	319	16	Chimeric	chimeric	JJ
cord-341050-hnuogpqn	319	17	dengue	dengue	NN
cord-341050-hnuogpqn	319	18	2	2	CD
cord-341050-hnuogpqn	319	19	PDK-53/	PDK-53/	NNS
cord-341050-hnuogpqn	320	1	West	West	NNP
cord-341050-hnuogpqn	320	2	Nile	Nile	NNP
cord-341050-hnuogpqn	321	1	NY99	NY99	NNP
cord-341050-hnuogpqn	321	2	viruses	virus	NNS
cord-341050-hnuogpqn	321	3	retain	retain	VBP
cord-341050-hnuogpqn	321	4	the	the	DT
cord-341050-hnuogpqn	321	5	phenotypic	phenotypic	JJ
cord-341050-hnuogpqn	321	6	attenuation	attenuation	NN
cord-341050-hnuogpqn	321	7	markers	marker	NNS
cord-341050-hnuogpqn	321	8	of	of	IN
cord-341050-hnuogpqn	321	9	the	the	DT
cord-341050-hnuogpqn	321	10	candidate	candidate	NN
cord-341050-hnuogpqn	321	11	PDK-53	PDK-53	NNP
cord-341050-hnuogpqn	321	12	vaccine	vaccine	NN
cord-341050-hnuogpqn	321	13	virus	virus	NN
cord-341050-hnuogpqn	321	14	and	and	CC
cord-341050-hnuogpqn	321	15	protect	protect	VB
cord-341050-hnuogpqn	321	16	mice	mouse	NNS
cord-341050-hnuogpqn	321	17	against	against	IN
cord-341050-hnuogpqn	321	18	lethal	lethal	JJ
cord-341050-hnuogpqn	321	19	challenge	challenge	NN
cord-341050-hnuogpqn	321	20	with	with	IN
cord-341050-hnuogpqn	321	21	West	West	NNP
cord-341050-hnuogpqn	321	22	Nile	Nile	NNP
cord-341050-hnuogpqn	321	23	virus	virus	NN
cord-341050-hnuogpqn	322	1	An	an	DT
cord-341050-hnuogpqn	322	2	attenuated	attenuated	JJ
cord-341050-hnuogpqn	322	3	West	West	NNP
cord-341050-hnuogpqn	322	4	Nile	Nile	NNP
cord-341050-hnuogpqn	322	5	prototype	prototype	NN
cord-341050-hnuogpqn	322	6	virus	virus	NN
cord-341050-hnuogpqn	322	7	is	be	VBZ
cord-341050-hnuogpqn	322	8	highly	highly	RB
cord-341050-hnuogpqn	322	9	immunogenic	immunogenic	JJ
cord-341050-hnuogpqn	322	10	and	and	CC
cord-341050-hnuogpqn	322	11	protects	protect	VBZ
cord-341050-hnuogpqn	322	12	against	against	IN
cord-341050-hnuogpqn	322	13	the	the	DT
cord-341050-hnuogpqn	322	14	deadly	deadly	JJ
cord-341050-hnuogpqn	322	15	NY99	NY99	NNP
cord-341050-hnuogpqn	322	16	strain	strain	NN
cord-341050-hnuogpqn	322	17	:	:	:
cord-341050-hnuogpqn	322	18	a	a	DT
cord-341050-hnuogpqn	322	19	candidate	candidate	NN
cord-341050-hnuogpqn	322	20	for	for	IN
cord-341050-hnuogpqn	322	21	live	live	JJ
cord-341050-hnuogpqn	322	22	WN	WN	NNP
cord-341050-hnuogpqn	322	23	vaccine	vaccine	NN
cord-341050-hnuogpqn	322	24	development	development	NN
cord-341050-hnuogpqn	322	25	Liveattenuated	Liveattenuated	NNP
cord-341050-hnuogpqn	322	26	recombinant	recombinant	JJ
cord-341050-hnuogpqn	322	27	equine	equine	JJ
cord-341050-hnuogpqn	322	28	herpesvirus	herpesvirus	NN
cord-341050-hnuogpqn	322	29	type	type	NN
cord-341050-hnuogpqn	322	30	1	1	CD
cord-341050-hnuogpqn	323	1	(	(	-LRB-
cord-341050-hnuogpqn	323	2	EHV-1	EHV-1	NNP
cord-341050-hnuogpqn	323	3	)	)	-RRB-
cord-341050-hnuogpqn	323	4	induces	induce	VBZ
cord-341050-hnuogpqn	323	5	a	a	DT
cord-341050-hnuogpqn	323	6	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	323	7	antibody	antibody	NN
cord-341050-hnuogpqn	323	8	response	response	NN
cord-341050-hnuogpqn	323	9	against	against	IN
cord-341050-hnuogpqn	323	10	West	West	NNP
cord-341050-hnuogpqn	323	11	Nile	Nile	NNP
cord-341050-hnuogpqn	323	12	virus	virus	NN
cord-341050-hnuogpqn	323	13	(	(	-LRB-
cord-341050-hnuogpqn	323	14	WNV	WNV	NNP
cord-341050-hnuogpqn	323	15	)	)	-RRB-
cord-341050-hnuogpqn	323	16	Equine	equine	JJ
cord-341050-hnuogpqn	323	17	vaccine	vaccine	NN
cord-341050-hnuogpqn	323	18	for	for	IN
cord-341050-hnuogpqn	323	19	West	West	NNP
cord-341050-hnuogpqn	323	20	Nile	Nile	NNP
cord-341050-hnuogpqn	323	21	virus	virus	NN
cord-341050-hnuogpqn	324	1	The	the	DT
cord-341050-hnuogpqn	324	2	effi	effi	NNP
cord-341050-hnuogpqn	324	3	cacy	cacy	NN
cord-341050-hnuogpqn	324	4	of	of	IN
cord-341050-hnuogpqn	324	5	inactivated	inactivate	VBN
cord-341050-hnuogpqn	324	6	West	West	NNP
cord-341050-hnuogpqn	324	7	Nile	Nile	NNP
cord-341050-hnuogpqn	324	8	vaccine	vaccine	NN
cord-341050-hnuogpqn	324	9	(	(	-LRB-
cord-341050-hnuogpqn	324	10	WN	WN	NNP
cord-341050-hnuogpqn	324	11	-	-	HYPH
cord-341050-hnuogpqn	324	12	VAX	VAX	NNP
cord-341050-hnuogpqn	324	13	)	)	-RRB-
cord-341050-hnuogpqn	324	14	in	in	IN
cord-341050-hnuogpqn	324	15	mice	mouse	NNS
cord-341050-hnuogpqn	324	16	and	and	CC
cord-341050-hnuogpqn	324	17	monkeys	monkey	NNS
cord-341050-hnuogpqn	324	18	Safety	Safety	NNP
cord-341050-hnuogpqn	324	19	and	and	CC
cord-341050-hnuogpqn	324	20	effi	effi	NNP
cord-341050-hnuogpqn	324	21	cacy	cacy	NNP
cord-341050-hnuogpqn	324	22	in	in	IN
cord-341050-hnuogpqn	324	23	geese	goose	NNS
cord-341050-hnuogpqn	324	24	of	of	IN
cord-341050-hnuogpqn	324	25	a	a	DT
cord-341050-hnuogpqn	324	26	PER.C6-based	per.c6-base	VBN
cord-341050-hnuogpqn	324	27	inactivated	inactivate	VBN
cord-341050-hnuogpqn	324	28	West	West	NNP
cord-341050-hnuogpqn	324	29	Nile	Nile	NNP
cord-341050-hnuogpqn	324	30	virus	virus	NN
cord-341050-hnuogpqn	324	31	vaccine	vaccine	NN
cord-341050-hnuogpqn	325	1	A	a	DT
cord-341050-hnuogpqn	325	2	hydrogen	hydrogen	NN
cord-341050-hnuogpqn	325	3	peroxide	peroxide	NN
cord-341050-hnuogpqn	325	4	-	-	HYPH
cord-341050-hnuogpqn	325	5	inactivated	inactivate	VBN
cord-341050-hnuogpqn	325	6	virus	virus	NN
cord-341050-hnuogpqn	325	7	vaccine	vaccine	NN
cord-341050-hnuogpqn	325	8	elicits	elicit	VBZ
cord-341050-hnuogpqn	325	9	humoral	humoral	JJ
cord-341050-hnuogpqn	325	10	and	and	CC
cord-341050-hnuogpqn	325	11	cellular	cellular	JJ
cord-341050-hnuogpqn	325	12	immunity	immunity	NN
cord-341050-hnuogpqn	325	13	and	and	CC
cord-341050-hnuogpqn	325	14	protects	protect	VBZ
cord-341050-hnuogpqn	325	15	against	against	IN
cord-341050-hnuogpqn	325	16	lethal	lethal	JJ
cord-341050-hnuogpqn	325	17	West	West	NNP
cord-341050-hnuogpqn	325	18	Nile	Nile	NNP
cord-341050-hnuogpqn	325	19	virus	virus	NN
cord-341050-hnuogpqn	325	20	infection	infection	NN
cord-341050-hnuogpqn	325	21	in	in	IN
cord-341050-hnuogpqn	325	22	aged	aged	JJ
cord-341050-hnuogpqn	325	23	mice	mouse	NNS
cord-341050-hnuogpqn	325	24	Development	Development	NNP
cord-341050-hnuogpqn	325	25	of	of	IN
cord-341050-hnuogpqn	325	26	a	a	DT
cord-341050-hnuogpqn	325	27	new	new	JJ
cord-341050-hnuogpqn	325	28	hydrogen	hydrogen	NN
cord-341050-hnuogpqn	325	29	peroxidebased	peroxidebased	JJ
cord-341050-hnuogpqn	325	30	vaccine	vaccine	NN
cord-341050-hnuogpqn	325	31	platform	platform	NN
cord-341050-hnuogpqn	325	32	Phylogeny	Phylogeny	NNP
cord-341050-hnuogpqn	325	33	and	and	CC
cord-341050-hnuogpqn	325	34	molecular	molecular	JJ
cord-341050-hnuogpqn	325	35	epidemiology	epidemiology	NN
cord-341050-hnuogpqn	325	36	of	of	IN
cord-341050-hnuogpqn	325	37	West	West	NNP
cord-341050-hnuogpqn	325	38	Nile	Nile	NNP
cord-341050-hnuogpqn	325	39	and	and	CC
cord-341050-hnuogpqn	325	40	Kunjin	Kunjin	NNP
cord-341050-hnuogpqn	325	41	viruses	virus	NNS
cord-341050-hnuogpqn	326	1	West	West	NNP
cord-341050-hnuogpqn	326	2	Nile	Nile	NNP
cord-341050-hnuogpqn	326	3	virus	virus	NN
cord-341050-hnuogpqn	326	4	(	(	-LRB-
cord-341050-hnuogpqn	326	5	Kunjin	Kunjin	NNP
cord-341050-hnuogpqn	326	6	subtype	subtype	NN
cord-341050-hnuogpqn	326	7	)	)	-RRB-
cord-341050-hnuogpqn	326	8	disease	disease	NN
cord-341050-hnuogpqn	326	9	in	in	IN
cord-341050-hnuogpqn	326	10	the	the	DT
cord-341050-hnuogpqn	326	11	northern	northern	JJ
cord-341050-hnuogpqn	326	12	territory	territory	NN
cord-341050-hnuogpqn	326	13	of	of	IN
cord-341050-hnuogpqn	326	14	Australia	Australia	NNP
cord-341050-hnuogpqn	326	15	-	-	:
cord-341050-hnuogpqn	326	16	a	a	DT
cord-341050-hnuogpqn	326	17	case	case	NN
cord-341050-hnuogpqn	326	18	of	of	IN
cord-341050-hnuogpqn	326	19	encephalitis	encephalitis	NN
cord-341050-hnuogpqn	326	20	and	and	CC
cord-341050-hnuogpqn	326	21	review	review	NN
cord-341050-hnuogpqn	326	22	of	of	IN
cord-341050-hnuogpqn	326	23	all	all	DT
cord-341050-hnuogpqn	326	24	reported	report	VBN
cord-341050-hnuogpqn	326	25	cases	case	NNS
cord-341050-hnuogpqn	327	1	An	an	DT
cord-341050-hnuogpqn	327	2	inactivated	inactivate	VBN
cord-341050-hnuogpqn	327	3	West	West	NNP
cord-341050-hnuogpqn	327	4	Nile	Nile	NNP
cord-341050-hnuogpqn	327	5	virus	virus	NN
cord-341050-hnuogpqn	327	6	vaccine	vaccine	NN
cord-341050-hnuogpqn	327	7	derived	derive	VBN
cord-341050-hnuogpqn	327	8	from	from	IN
cord-341050-hnuogpqn	327	9	a	a	DT
cord-341050-hnuogpqn	327	10	chemically	chemically	RB
cord-341050-hnuogpqn	327	11	synthesized	synthesize	VBN
cord-341050-hnuogpqn	327	12	cDNA	cdna	NN
cord-341050-hnuogpqn	327	13	system	system	NN
cord-341050-hnuogpqn	327	14	Immunization	Immunization	NNP
cord-341050-hnuogpqn	327	15	with	with	IN
cord-341050-hnuogpqn	327	16	West	West	NNP
cord-341050-hnuogpqn	327	17	Nile	Nile	NNP
cord-341050-hnuogpqn	327	18	virus	virus	NN
cord-341050-hnuogpqn	327	19	envelope	envelope	NN
cord-341050-hnuogpqn	327	20	domain	domain	NN
cord-341050-hnuogpqn	327	21	III	III	NNP
cord-341050-hnuogpqn	327	22	protects	protect	VBZ
cord-341050-hnuogpqn	327	23	mice	mouse	NNS
cord-341050-hnuogpqn	327	24	against	against	IN
cord-341050-hnuogpqn	327	25	lethal	lethal	JJ
cord-341050-hnuogpqn	327	26	infection	infection	NN
cord-341050-hnuogpqn	327	27	with	with	IN
cord-341050-hnuogpqn	327	28	homologous	homologous	JJ
cord-341050-hnuogpqn	327	29	and	and	CC
cord-341050-hnuogpqn	327	30	heterologous	heterologous	JJ
cord-341050-hnuogpqn	327	31	virus	virus	NN
cord-341050-hnuogpqn	327	32	Preparation	preparation	NN
cord-341050-hnuogpqn	327	33	and	and	CC
cord-341050-hnuogpqn	327	34	immunogenic	immunogenic	JJ
cord-341050-hnuogpqn	327	35	properties	property	NNS
cord-341050-hnuogpqn	327	36	of	of	IN
cord-341050-hnuogpqn	327	37	a	a	DT
cord-341050-hnuogpqn	327	38	recombinant	recombinant	JJ
cord-341050-hnuogpqn	327	39	West	West	NNP
cord-341050-hnuogpqn	327	40	Nile	Nile	NNP
cord-341050-hnuogpqn	327	41	subunit	subunit	NN
cord-341050-hnuogpqn	327	42	vaccine	vaccine	NN
cord-341050-hnuogpqn	327	43	A	a	DT
cord-341050-hnuogpqn	327	44	West	West	NNP
cord-341050-hnuogpqn	327	45	Nile	Nile	NNP
cord-341050-hnuogpqn	327	46	virus	virus	NN
cord-341050-hnuogpqn	327	47	recombinant	recombinant	JJ
cord-341050-hnuogpqn	327	48	protein	protein	NN
cord-341050-hnuogpqn	327	49	vaccine	vaccine	NN
cord-341050-hnuogpqn	327	50	that	that	WDT
cord-341050-hnuogpqn	327	51	coactivates	coactivate	VBZ
cord-341050-hnuogpqn	327	52	innate	innate	JJ
cord-341050-hnuogpqn	327	53	and	and	CC
cord-341050-hnuogpqn	327	54	adaptive	adaptive	JJ
cord-341050-hnuogpqn	327	55	immunity	immunity	NN
cord-341050-hnuogpqn	328	1	A	a	DT
cord-341050-hnuogpqn	328	2	VLP	VLP	NNP
cord-341050-hnuogpqn	328	3	-	-	HYPH
cord-341050-hnuogpqn	328	4	based	base	VBN
cord-341050-hnuogpqn	328	5	vaccine	vaccine	NN
cord-341050-hnuogpqn	328	6	targeting	target	VBG
cord-341050-hnuogpqn	328	7	domain	domain	NN
cord-341050-hnuogpqn	328	8	III	iii	CD
cord-341050-hnuogpqn	328	9	of	of	IN
cord-341050-hnuogpqn	328	10	the	the	DT
cord-341050-hnuogpqn	328	11	West	West	NNP
cord-341050-hnuogpqn	328	12	Nile	Nile	NNP
cord-341050-hnuogpqn	328	13	virus	virus	NN
cord-341050-hnuogpqn	328	14	E	e	NN
cord-341050-hnuogpqn	328	15	protein	protein	NN
cord-341050-hnuogpqn	328	16	protects	protect	VBZ
cord-341050-hnuogpqn	328	17	from	from	IN
cord-341050-hnuogpqn	328	18	lethal	lethal	JJ
cord-341050-hnuogpqn	328	19	infection	infection	NN
cord-341050-hnuogpqn	328	20	in	in	IN
cord-341050-hnuogpqn	328	21	mice	mouse	NNS
cord-341050-hnuogpqn	329	1	A	a	DT
cord-341050-hnuogpqn	329	2	novel	novel	JJ
cord-341050-hnuogpqn	329	3	platform	platform	NN
cord-341050-hnuogpqn	329	4	for	for	IN
cord-341050-hnuogpqn	329	5	virus	virus	NN
cord-341050-hnuogpqn	329	6	-	-	HYPH
cord-341050-hnuogpqn	329	7	like	like	JJ
cord-341050-hnuogpqn	329	8	particle	particle	NN
cord-341050-hnuogpqn	329	9	-	-	HYPH
cord-341050-hnuogpqn	329	10	display	display	NN
cord-341050-hnuogpqn	329	11	of	of	IN
cord-341050-hnuogpqn	329	12	fl	fl	NNP
cord-341050-hnuogpqn	329	13	aviviral	aviviral	NNP
cord-341050-hnuogpqn	329	14	envelope	envelope	NN
cord-341050-hnuogpqn	329	15	domain	domain	NN
cord-341050-hnuogpqn	329	16	III	III	NNP
cord-341050-hnuogpqn	329	17	:	:	:
cord-341050-hnuogpqn	329	18	induction	induction	NN
cord-341050-hnuogpqn	329	19	of	of	IN
cord-341050-hnuogpqn	329	20	Dengue	Dengue	NNP
cord-341050-hnuogpqn	329	21	and	and	CC
cord-341050-hnuogpqn	329	22	West	West	NNP
cord-341050-hnuogpqn	329	23	Nile	Nile	NNP
cord-341050-hnuogpqn	329	24	virus	virus	NN
cord-341050-hnuogpqn	329	25	neutralizing	neutralize	VBG
cord-341050-hnuogpqn	329	26	antibodies	antibody	NNS
cord-341050-hnuogpqn	329	27	Dhiraj	Dhiraj	NNP
cord-341050-hnuogpqn	329	28	Acharya	Acharya	NNP
cord-341050-hnuogpqn	329	29	and	and	CC
cord-341050-hnuogpqn	329	30	Fengwei	Fengwei	NNP
cord-341050-hnuogpqn	329	31	Bai	Bai	NNP
cord-341050-hnuogpqn	329	32	duction	duction	NN
cord-341050-hnuogpqn	329	33	of	of	IN
cord-341050-hnuogpqn	329	34	detection	detection	NN
cord-341050-hnuogpqn	329	35	and	and	CC
cord-341050-hnuogpqn	329	36	diagnostic	diagnostic	JJ
cord-341050-hnuogpqn	329	37	reagents	reagent	NNS
cord-341050-hnuogpqn	329	38	of	of	IN
cord-341050-hnuogpqn	329	39	West	West	NNP
cord-341050-hnuogpqn	329	40	Nile	Nile	NNP
cord-341050-hnuogpqn	329	41	virus	virus	NN
cord-341050-hnuogpqn	329	42	in	in	IN
cord-341050-hnuogpqn	329	43	plants	plant	NNS
cord-341050-hnuogpqn	329	44	Plant	Plant	NNP
cord-341050-hnuogpqn	329	45	-	-	HYPH
cord-341050-hnuogpqn	329	46	made	make	VBN
cord-341050-hnuogpqn	329	47	vaccines	vaccine	NNS
cord-341050-hnuogpqn	329	48	against	against	IN
cord-341050-hnuogpqn	329	49	West	West	NNP
cord-341050-hnuogpqn	329	50	Nile	Nile	NNP
cord-341050-hnuogpqn	329	51	virus	virus	NN
cord-341050-hnuogpqn	329	52	are	be	VBP
cord-341050-hnuogpqn	329	53	potent	potent	JJ
cord-341050-hnuogpqn	329	54	,	,	,
cord-341050-hnuogpqn	329	55	safe	safe	JJ
cord-341050-hnuogpqn	329	56	,	,	,
cord-341050-hnuogpqn	329	57	and	and	CC
cord-341050-hnuogpqn	329	58	economically	economically	RB
cord-341050-hnuogpqn	329	59	feasible	feasible	JJ
cord-341050-hnuogpqn	329	60	Monoclonal	monoclonal	JJ
cord-341050-hnuogpqn	329	61	antibody	antibody	NN
cord-341050-hnuogpqn	329	62	produced	produce	VBN
cord-341050-hnuogpqn	329	63	in	in	IN
cord-341050-hnuogpqn	329	64	plants	plant	NNS
cord-341050-hnuogpqn	329	65	efficiently	efficiently	RB
cord-341050-hnuogpqn	329	66	treats	treat	VBZ
cord-341050-hnuogpqn	329	67	West	West	NNP
cord-341050-hnuogpqn	329	68	Nile	Nile	NNP
cord-341050-hnuogpqn	329	69	virus	virus	NN
cord-341050-hnuogpqn	329	70	infection	infection	NN
cord-341050-hnuogpqn	329	71	in	in	IN
cord-341050-hnuogpqn	329	72	mice	mouse	NNS
cord-341050-hnuogpqn	330	1	The	the	DT
cord-341050-hnuogpqn	330	2	structural	structural	JJ
cord-341050-hnuogpqn	330	3	immunology	immunology	NN
cord-341050-hnuogpqn	330	4	of	of	IN
cord-341050-hnuogpqn	330	5	antibody	antibody	NN
cord-341050-hnuogpqn	330	6	protection	protection	NN
cord-341050-hnuogpqn	330	7	against	against	IN
cord-341050-hnuogpqn	330	8	West	West	NNP
cord-341050-hnuogpqn	330	9	Nile	Nile	NNP
cord-341050-hnuogpqn	330	10	virus	virus	NN
cord-341050-hnuogpqn	331	1	The	the	DT
cord-341050-hnuogpqn	331	2	molecular	molecular	JJ
cord-341050-hnuogpqn	331	3	basis	basis	NN
cord-341050-hnuogpqn	331	4	of	of	IN
cord-341050-hnuogpqn	331	5	antibody	antibody	NN
cord-341050-hnuogpqn	331	6	-	-	HYPH
cord-341050-hnuogpqn	331	7	mediated	mediate	VBN
cord-341050-hnuogpqn	331	8	neutralization	neutralization	NN
cord-341050-hnuogpqn	331	9	of	of	IN
cord-341050-hnuogpqn	331	10	West	West	NNP
cord-341050-hnuogpqn	331	11	Nile	Nile	NNP
cord-341050-hnuogpqn	331	12	virus	virus	NN
cord-341050-hnuogpqn	331	13	Antibody	Antibody	NNP
cord-341050-hnuogpqn	331	14	engineering	engineering	NNP
cord-341050-hnuogpqn	331	15	Antibody	Antibody	NNP
cord-341050-hnuogpqn	331	16	engineering	engineering	NN
cord-341050-hnuogpqn	331	17	and	and	CC
cord-341050-hnuogpqn	331	18	modifi	modifi	NN
cord-341050-hnuogpqn	331	19	cation	cation	NN
cord-341050-hnuogpqn	331	20	technologies	technology	NNS
cord-341050-hnuogpqn	331	21	Glycoengineering	Glycoengineering	NNP
cord-341050-hnuogpqn	331	22	of	of	IN
cord-341050-hnuogpqn	331	23	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	331	24	antibodies	antibody	NNS
cord-341050-hnuogpqn	331	25	enhances	enhance	VBZ
cord-341050-hnuogpqn	331	26	monocyte	monocyte	NNP
cord-341050-hnuogpqn	331	27	/	/	SYM
cord-341050-hnuogpqn	331	28	macrophage	macrophage	NN
cord-341050-hnuogpqn	331	29	-	-	HYPH
cord-341050-hnuogpqn	331	30	mediated	mediate	VBN
cord-341050-hnuogpqn	331	31	phagocytosis	phagocytosis	NN
cord-341050-hnuogpqn	331	32	and	and	CC
cord-341050-hnuogpqn	331	33	cytotoxicity	cytotoxicity	NN
cord-341050-hnuogpqn	331	34	A	a	DT
cord-341050-hnuogpqn	331	35	paradoxical	paradoxical	JJ
cord-341050-hnuogpqn	331	36	role	role	NN
cord-341050-hnuogpqn	331	37	for	for	IN
cord-341050-hnuogpqn	331	38	neutrophils	neutrophil	NNS
cord-341050-hnuogpqn	331	39	in	in	IN
cord-341050-hnuogpqn	331	40	the	the	DT
cord-341050-hnuogpqn	331	41	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	331	42	of	of	IN
cord-341050-hnuogpqn	331	43	West	West	NNP
cord-341050-hnuogpqn	331	44	Nile	Nile	NNP
cord-341050-hnuogpqn	331	45	virus	virus	NN
cord-341050-hnuogpqn	331	46	IL-10	IL-10	NNP
cord-341050-hnuogpqn	331	47	signaling	signal	VBG
cord-341050-hnuogpqn	331	48	blockade	blockade	NN
cord-341050-hnuogpqn	331	49	controls	control	NNS
cord-341050-hnuogpqn	331	50	murine	murine	JJ
cord-341050-hnuogpqn	331	51	West	West	NNP
cord-341050-hnuogpqn	331	52	Nile	Nile	NNP
cord-341050-hnuogpqn	331	53	virus	virus	NN
cord-341050-hnuogpqn	331	54	infection	infection	NN
cord-341050-hnuogpqn	331	55	Use	Use	NNP
cord-341050-hnuogpqn	331	56	of	of	IN
cord-341050-hnuogpqn	331	57	RNA	RNA	NNP
cord-341050-hnuogpqn	331	58	interference	interference	NN
cord-341050-hnuogpqn	331	59	to	to	TO
cord-341050-hnuogpqn	331	60	prevent	prevent	VB
cord-341050-hnuogpqn	331	61	lethal	lethal	JJ
cord-341050-hnuogpqn	331	62	murine	murine	JJ
cord-341050-hnuogpqn	331	63	West	West	NNP
cord-341050-hnuogpqn	331	64	Nile	Nile	NNP
cord-341050-hnuogpqn	331	65	virus	virus	NN
cord-341050-hnuogpqn	331	66	infection	infection	NN
cord-341050-hnuogpqn	331	67	Toll	toll	NN
cord-341050-hnuogpqn	331	68	-	-	HYPH
cord-341050-hnuogpqn	331	69	like	like	JJ
cord-341050-hnuogpqn	331	70	receptor	receptor	NN
cord-341050-hnuogpqn	331	71	7	7	CD
cord-341050-hnuogpqn	331	72	mitigates	mitigate	VBZ
cord-341050-hnuogpqn	331	73	lethal	lethal	JJ
cord-341050-hnuogpqn	331	74	West	West	NNP
cord-341050-hnuogpqn	331	75	Nile	Nile	NNP
cord-341050-hnuogpqn	331	76	encephalitis	encephalitis	RB
cord-341050-hnuogpqn	331	77	via	via	IN
cord-341050-hnuogpqn	331	78	interleukin	interleukin	NN
cord-341050-hnuogpqn	331	79	23-dependent	23-dependent	CD
cord-341050-hnuogpqn	331	80	immune	immune	JJ
cord-341050-hnuogpqn	331	81	cell	cell	NN
cord-341050-hnuogpqn	331	82	infi	infi	NNP
cord-341050-hnuogpqn	331	83	ltration	ltration	NN
cord-341050-hnuogpqn	331	84	and	and	CC
cord-341050-hnuogpqn	331	85	homing	home	VBG
cord-341050-hnuogpqn	331	86	Ten	ten	CD
cord-341050-hnuogpqn	331	87	years	year	NNS
cord-341050-hnuogpqn	331	88	of	of	IN
cord-341050-hnuogpqn	331	89	dengue	dengue	NN
cord-341050-hnuogpqn	331	90	drug	drug	NN
cord-341050-hnuogpqn	331	91	discovery	discovery	NN
cord-341050-hnuogpqn	331	92	:	:	:
cord-341050-hnuogpqn	331	93	progress	progress	NN
cord-341050-hnuogpqn	331	94	and	and	CC
cord-341050-hnuogpqn	331	95	prospects	prospect	NNS
cord-341050-hnuogpqn	331	96	Designing	design	VBG
cord-341050-hnuogpqn	331	97	screens	screen	NNS
cord-341050-hnuogpqn	331	98	:	:	:
cord-341050-hnuogpqn	331	99	how	how	WRB
cord-341050-hnuogpqn	331	100	to	to	TO
cord-341050-hnuogpqn	331	101	make	make	VB
cord-341050-hnuogpqn	331	102	your	-PRON-	PRP$
cord-341050-hnuogpqn	331	103	hits	hit	NNS
cord-341050-hnuogpqn	331	104	a	a	DT
cord-341050-hnuogpqn	331	105	hit	hit	VBN
cord-341050-hnuogpqn	331	106	Principles	principle	NNS
cord-341050-hnuogpqn	331	107	of	of	IN
cord-341050-hnuogpqn	331	108	early	early	JJ
cord-341050-hnuogpqn	331	109	drug	drug	NN
cord-341050-hnuogpqn	331	110	discovery	discovery	NN
cord-341050-hnuogpqn	332	1	Novel	novel	JJ
cord-341050-hnuogpqn	332	2	trends	trend	NNS
cord-341050-hnuogpqn	332	3	in	in	IN
cord-341050-hnuogpqn	332	4	high	high	JJ
cord-341050-hnuogpqn	332	5	-	-	HYPH
cord-341050-hnuogpqn	332	6	throughput	throughput	NN
cord-341050-hnuogpqn	332	7	screening	screen	VBG
cord-341050-hnuogpqn	332	8	Review	Review	NNP
cord-341050-hnuogpqn	332	9	article	article	NN
cord-341050-hnuogpqn	332	10	:	:	:
cord-341050-hnuogpqn	332	11	high	high	JJ
cord-341050-hnuogpqn	332	12	-	-	HYPH
cord-341050-hnuogpqn	332	13	throughput	throughput	NN
cord-341050-hnuogpqn	332	14	affi	affi	FW
cord-341050-hnuogpqn	332	15	nity	nity	NN
cord-341050-hnuogpqn	332	16	-	-	HYPH
cord-341050-hnuogpqn	332	17	based	base	VBN
cord-341050-hnuogpqn	332	18	technologies	technology	NNS
cord-341050-hnuogpqn	332	19	for	for	IN
cord-341050-hnuogpqn	332	20	small	small	JJ
cord-341050-hnuogpqn	332	21	-	-	HYPH
cord-341050-hnuogpqn	332	22	molecule	molecule	NN
cord-341050-hnuogpqn	332	23	drug	drug	NN
cord-341050-hnuogpqn	332	24	discovery	discovery	NN
cord-341050-hnuogpqn	332	25	Fragment	Fragment	NNP
cord-341050-hnuogpqn	332	26	screening	screening	NN
cord-341050-hnuogpqn	332	27	using	use	VBG
cord-341050-hnuogpqn	332	28	X	x	NN
cord-341050-hnuogpqn	332	29	-	-	NN
cord-341050-hnuogpqn	332	30	ray	ray	NN
cord-341050-hnuogpqn	332	31	crystallography	crystallography	NN
cord-341050-hnuogpqn	332	32	Affi	Affi	NNP
cord-341050-hnuogpqn	332	33	nity	nity	NN
cord-341050-hnuogpqn	332	34	-	-	HYPH
cord-341050-hnuogpqn	332	35	based	base	VBN
cord-341050-hnuogpqn	332	36	screening	screening	NN
cord-341050-hnuogpqn	332	37	techniques	technique	NNS
cord-341050-hnuogpqn	332	38	:	:	:
cord-341050-hnuogpqn	332	39	their	-PRON-	PRP$
cord-341050-hnuogpqn	332	40	impact	impact	NN
cord-341050-hnuogpqn	332	41	and	and	CC
cord-341050-hnuogpqn	332	42	benefi	benefi	NNP
cord-341050-hnuogpqn	332	43	t	t	NNP
cord-341050-hnuogpqn	332	44	to	to	TO
cord-341050-hnuogpqn	332	45	increase	increase	VB
cord-341050-hnuogpqn	332	46	the	the	DT
cord-341050-hnuogpqn	332	47	number	number	NN
cord-341050-hnuogpqn	332	48	of	of	IN
cord-341050-hnuogpqn	332	49	high	high	JJ
cord-341050-hnuogpqn	332	50	quality	quality	NN
cord-341050-hnuogpqn	332	51	leads	lead	VBZ
cord-341050-hnuogpqn	332	52	Solution	Solution	NNP
cord-341050-hnuogpqn	332	53	structure	structure	NN
cord-341050-hnuogpqn	332	54	of	of	IN
cord-341050-hnuogpqn	332	55	dengue	dengue	NN
cord-341050-hnuogpqn	332	56	virus	virus	NN
cord-341050-hnuogpqn	332	57	capsid	capsid	NN
cord-341050-hnuogpqn	332	58	protein	protein	NN
cord-341050-hnuogpqn	332	59	reveals	reveal	VBZ
cord-341050-hnuogpqn	332	60	another	another	DT
cord-341050-hnuogpqn	332	61	fold	fold	NN
cord-341050-hnuogpqn	332	62	The	the	DT
cord-341050-hnuogpqn	332	63	fl	fl	NNP
cord-341050-hnuogpqn	332	64	avivirus	avivirus	NN
cord-341050-hnuogpqn	332	65	precursor	precursor	NN
cord-341050-hnuogpqn	332	66	membrane	membrane	NN
cord-341050-hnuogpqn	332	67	-	-	HYPH
cord-341050-hnuogpqn	332	68	envelope	envelope	NN
cord-341050-hnuogpqn	332	69	protein	protein	NN
cord-341050-hnuogpqn	332	70	complex	complex	NN
cord-341050-hnuogpqn	332	71	:	:	:
cord-341050-hnuogpqn	332	72	structure	structure	NN
cord-341050-hnuogpqn	332	73	and	and	CC
cord-341050-hnuogpqn	332	74	maturation	maturation	NN
cord-341050-hnuogpqn	332	75	Structure	Structure	NNP
cord-341050-hnuogpqn	332	76	of	of	IN
cord-341050-hnuogpqn	332	77	immature	immature	JJ
cord-341050-hnuogpqn	332	78	West	West	NNP
cord-341050-hnuogpqn	332	79	Nile	Nile	NNP
cord-341050-hnuogpqn	332	80	virus	virus	NN
cord-341050-hnuogpqn	333	1	A	a	DT
cord-341050-hnuogpqn	333	2	high	high	JJ
cord-341050-hnuogpqn	333	3	-	-	HYPH
cord-341050-hnuogpqn	333	4	throughput	throughput	NN
cord-341050-hnuogpqn	333	5	screening	screening	NN
cord-341050-hnuogpqn	333	6	assay	assay	NN
cord-341050-hnuogpqn	333	7	for	for	IN
cord-341050-hnuogpqn	333	8	the	the	DT
cord-341050-hnuogpqn	333	9	identifi	identifi	NNP
cord-341050-hnuogpqn	333	10	cation	cation	NNP
cord-341050-hnuogpqn	333	11	of	of	IN
cord-341050-hnuogpqn	333	12	fl	fl	NNP
cord-341050-hnuogpqn	333	13	avivirus	avivirus	NNP
cord-341050-hnuogpqn	333	14	NS5	ns5	JJ
cord-341050-hnuogpqn	333	15	capping	cap	VBG
cord-341050-hnuogpqn	333	16	enzyme	enzyme	NN
cord-341050-hnuogpqn	333	17	GTP	gtp	NN
cord-341050-hnuogpqn	333	18	-	-	HYPH
cord-341050-hnuogpqn	333	19	binding	bind	VBG
cord-341050-hnuogpqn	333	20	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	333	21	:	:	:
cord-341050-hnuogpqn	333	22	implications	implication	NNS
cord-341050-hnuogpqn	333	23	for	for	IN
cord-341050-hnuogpqn	333	24	antiviral	antiviral	JJ
cord-341050-hnuogpqn	333	25	drug	drug	NN
cord-341050-hnuogpqn	333	26	development	development	NN
cord-341050-hnuogpqn	333	27	Discovery	Discovery	NNP
cord-341050-hnuogpqn	333	28	of	of	IN
cord-341050-hnuogpqn	333	29	small	small	JJ
cord-341050-hnuogpqn	333	30	molecule	molecule	NN
cord-341050-hnuogpqn	333	31	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	333	32	of	of	IN
cord-341050-hnuogpqn	333	33	West	West	NNP
cord-341050-hnuogpqn	333	34	Nile	Nile	NNP
cord-341050-hnuogpqn	333	35	virus	virus	NN
cord-341050-hnuogpqn	333	36	using	use	VBG
cord-341050-hnuogpqn	333	37	a	a	DT
cord-341050-hnuogpqn	333	38	high	high	JJ
cord-341050-hnuogpqn	333	39	-	-	HYPH
cord-341050-hnuogpqn	333	40	throughput	throughput	NN
cord-341050-hnuogpqn	333	41	sub	sub	JJ
cord-341050-hnuogpqn	333	42	-	-	JJ
cord-341050-hnuogpqn	333	43	genomic	genomic	JJ
cord-341050-hnuogpqn	333	44	replicon	replicon	NN
cord-341050-hnuogpqn	333	45	screen	screen	NN
cord-341050-hnuogpqn	334	1	HTS	HTS	NNP
cord-341050-hnuogpqn	334	2	identifi	identifi	NNP
cord-341050-hnuogpqn	335	1	es	es	NNP
cord-341050-hnuogpqn	335	2	novel	novel	NNP
cord-341050-hnuogpqn	335	3	and	and	CC
cord-341050-hnuogpqn	335	4	specifi	specifi	NNP
cord-341050-hnuogpqn	335	5	c	c	NNP
cord-341050-hnuogpqn	335	6	uncompetitive	uncompetitive	JJ
cord-341050-hnuogpqn	335	7	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	335	8	of	of	IN
cord-341050-hnuogpqn	335	9	the	the	DT
cord-341050-hnuogpqn	335	10	two	two	CD
cord-341050-hnuogpqn	335	11	-	-	HYPH
cord-341050-hnuogpqn	335	12	component	component	NN
cord-341050-hnuogpqn	335	13	NS2B	NS2B	NNP
cord-341050-hnuogpqn	335	14	-	-	:
cord-341050-hnuogpqn	335	15	NS3	ns3	RB
cord-341050-hnuogpqn	335	16	proteinase	proteinase	NN
cord-341050-hnuogpqn	335	17	of	of	IN
cord-341050-hnuogpqn	335	18	West	West	NNP
cord-341050-hnuogpqn	335	19	Nile	Nile	NNP
cord-341050-hnuogpqn	335	20	virus	virus	NN
cord-341050-hnuogpqn	335	21	In	in	IN
cord-341050-hnuogpqn	335	22	silico	silico	NN
cord-341050-hnuogpqn	335	23	screening	screening	NN
cord-341050-hnuogpqn	335	24	of	of	IN
cord-341050-hnuogpqn	335	25	small	small	JJ
cord-341050-hnuogpqn	335	26	molecule	molecule	NN
cord-341050-hnuogpqn	335	27	libraries	library	NNS
cord-341050-hnuogpqn	335	28	using	use	VBG
cord-341050-hnuogpqn	335	29	the	the	DT
cord-341050-hnuogpqn	335	30	dengue	dengue	NN
cord-341050-hnuogpqn	335	31	virus	virus	NN
cord-341050-hnuogpqn	335	32	envelope	envelope	NN
cord-341050-hnuogpqn	335	33	E	e	NN
cord-341050-hnuogpqn	335	34	protein	protein	NN
cord-341050-hnuogpqn	336	1	has	have	VBZ
cord-341050-hnuogpqn	336	2	identifi	identifi	NNP
cord-341050-hnuogpqn	336	3	ed	ed	NNP
cord-341050-hnuogpqn	336	4	compounds	compound	NNS
cord-341050-hnuogpqn	336	5	with	with	IN
cord-341050-hnuogpqn	336	6	antiviral	antiviral	JJ
cord-341050-hnuogpqn	336	7	activity	activity	NN
cord-341050-hnuogpqn	336	8	against	against	IN
cord-341050-hnuogpqn	336	9	multiple	multiple	JJ
cord-341050-hnuogpqn	336	10	fl	fl	NNP
cord-341050-hnuogpqn	336	11	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	336	12	Cell	cell	NN
cord-341050-hnuogpqn	336	13	-	-	HYPH
cord-341050-hnuogpqn	336	14	based	base	VBN
cord-341050-hnuogpqn	336	15	assays	assay	NNS
cord-341050-hnuogpqn	336	16	to	to	TO
cord-341050-hnuogpqn	336	17	identify	identify	VB
cord-341050-hnuogpqn	336	18	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	336	19	of	of	IN
cord-341050-hnuogpqn	336	20	viral	viral	JJ
cord-341050-hnuogpqn	336	21	disease	disease	NN
cord-341050-hnuogpqn	336	22	Current	current	JJ
cord-341050-hnuogpqn	336	23	approaches	approach	NNS
cord-341050-hnuogpqn	336	24	in	in	IN
cord-341050-hnuogpqn	336	25	antiviral	antiviral	JJ
cord-341050-hnuogpqn	336	26	drug	drug	NN
cord-341050-hnuogpqn	336	27	discovery	discovery	NN
cord-341050-hnuogpqn	336	28	against	against	IN
cord-341050-hnuogpqn	336	29	the	the	DT
cord-341050-hnuogpqn	336	30	Flaviviridae	Flaviviridae	NNP
cord-341050-hnuogpqn	336	31	family	family	NN
cord-341050-hnuogpqn	336	32	Novel	Novel	NNP
cord-341050-hnuogpqn	336	33	approaches	approach	NNS
cord-341050-hnuogpqn	336	34	to	to	IN
cord-341050-hnuogpqn	336	35	fl	fl	NNP
cord-341050-hnuogpqn	336	36	avivirus	avivirus	NNP
cord-341050-hnuogpqn	336	37	drug	drug	NNP
cord-341050-hnuogpqn	336	38	discovery	discovery	NN
cord-341050-hnuogpqn	337	1	Neuroblastoma	neuroblastoma	NN
cord-341050-hnuogpqn	337	2	cell	cell	NN
cord-341050-hnuogpqn	337	3	-	-	HYPH
cord-341050-hnuogpqn	337	4	adapted	adapt	VBN
cord-341050-hnuogpqn	337	5	yellow	yellow	JJ
cord-341050-hnuogpqn	337	6	fever	fever	NN
cord-341050-hnuogpqn	337	7	virus	virus	NN
cord-341050-hnuogpqn	337	8	:	:	:
cord-341050-hnuogpqn	337	9	mutagenesis	mutagenesis	NN
cord-341050-hnuogpqn	337	10	of	of	IN
cord-341050-hnuogpqn	337	11	the	the	DT
cord-341050-hnuogpqn	337	12	E	e	NN
cord-341050-hnuogpqn	337	13	protein	protein	NN
cord-341050-hnuogpqn	337	14	locus	locus	NN
cord-341050-hnuogpqn	337	15	involved	involve	VBN
cord-341050-hnuogpqn	337	16	in	in	IN
cord-341050-hnuogpqn	337	17	persistent	persistent	JJ
cord-341050-hnuogpqn	337	18	infection	infection	NN
cord-341050-hnuogpqn	337	19	and	and	CC
cord-341050-hnuogpqn	337	20	its	-PRON-	PRP$
cord-341050-hnuogpqn	337	21	effects	effect	NNS
cord-341050-hnuogpqn	337	22	on	on	IN
cord-341050-hnuogpqn	337	23	virus	virus	NN
cord-341050-hnuogpqn	337	24	penetration	penetration	NN
cord-341050-hnuogpqn	337	25	and	and	CC
cord-341050-hnuogpqn	337	26	spread	spread	VBD
cord-341050-hnuogpqn	337	27	The	the	DT
cord-341050-hnuogpqn	337	28	interactions	interaction	NNS
cord-341050-hnuogpqn	337	29	of	of	IN
cord-341050-hnuogpqn	337	30	the	the	DT
cord-341050-hnuogpqn	337	31	fl	fl	NNP
cord-341050-hnuogpqn	337	32	avivirus	avivirus	NNP
cord-341050-hnuogpqn	337	33	envelope	envelope	NN
cord-341050-hnuogpqn	337	34	proteins	protein	NNS
cord-341050-hnuogpqn	337	35	:	:	:
cord-341050-hnuogpqn	337	36	implications	implication	NNS
cord-341050-hnuogpqn	337	37	for	for	IN
cord-341050-hnuogpqn	337	38	virus	virus	NN
cord-341050-hnuogpqn	337	39	entry	entry	NN
cord-341050-hnuogpqn	337	40	and	and	CC
cord-341050-hnuogpqn	337	41	release	release	VB
cord-341050-hnuogpqn	337	42	Infectious	infectious	JJ
cord-341050-hnuogpqn	337	43	entry	entry	NN
cord-341050-hnuogpqn	337	44	of	of	IN
cord-341050-hnuogpqn	337	45	West	West	NNP
cord-341050-hnuogpqn	337	46	Nile	Nile	NNP
cord-341050-hnuogpqn	337	47	virus	virus	NN
cord-341050-hnuogpqn	337	48	occurs	occur	VBZ
cord-341050-hnuogpqn	337	49	through	through	IN
cord-341050-hnuogpqn	337	50	a	a	DT
cord-341050-hnuogpqn	337	51	clathrinmediated	clathrinmediate	VBN
cord-341050-hnuogpqn	337	52	endocytic	endocytic	JJ
cord-341050-hnuogpqn	337	53	pathway	pathway	NN
cord-341050-hnuogpqn	337	54	HIV-1	HIV-1	NNP
cord-341050-hnuogpqn	337	55	entry	entry	NN
cord-341050-hnuogpqn	337	56	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	337	57	:	:	:
cord-341050-hnuogpqn	337	58	an	an	DT
cord-341050-hnuogpqn	337	59	overview	overview	NN
cord-341050-hnuogpqn	337	60	Targeting	target	VBG
cord-341050-hnuogpqn	337	61	HIV-1	HIV-1	NNP
cord-341050-hnuogpqn	337	62	gp41-induced	gp41-induced	NNP
cord-341050-hnuogpqn	337	63	fusion	fusion	NN
cord-341050-hnuogpqn	337	64	and	and	CC
cord-341050-hnuogpqn	337	65	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	337	66	for	for	IN
cord-341050-hnuogpqn	337	67	anti	anti	JJ
cord-341050-hnuogpqn	337	68	-	-	JJ
cord-341050-hnuogpqn	337	69	viral	viral	JJ
cord-341050-hnuogpqn	337	70	therapy	therapy	NN
cord-341050-hnuogpqn	338	1	A	a	DT
cord-341050-hnuogpqn	338	2	ligand	ligand	NN
cord-341050-hnuogpqn	338	3	-	-	HYPH
cord-341050-hnuogpqn	338	4	binding	bind	VBG
cord-341050-hnuogpqn	338	5	pocket	pocket	NN
cord-341050-hnuogpqn	338	6	in	in	IN
cord-341050-hnuogpqn	338	7	the	the	DT
cord-341050-hnuogpqn	338	8	dengue	dengue	NN
cord-341050-hnuogpqn	338	9	virus	virus	NN
cord-341050-hnuogpqn	338	10	envelope	envelope	NN
cord-341050-hnuogpqn	338	11	glycoprotein	glycoprotein	NNP
cord-341050-hnuogpqn	338	12	Structure	Structure	NNP
cord-341050-hnuogpqn	338	13	of	of	IN
cord-341050-hnuogpqn	338	14	a	a	DT
cord-341050-hnuogpqn	338	15	fl	fl	NNP
cord-341050-hnuogpqn	338	16	avivirus	avivirus	NNP
cord-341050-hnuogpqn	338	17	envelope	envelope	NN
cord-341050-hnuogpqn	338	18	glycoprotein	glycoprotein	NN
cord-341050-hnuogpqn	338	19	in	in	IN
cord-341050-hnuogpqn	338	20	its	-PRON-	PRP$
cord-341050-hnuogpqn	338	21	low	low	JJ
cord-341050-hnuogpqn	338	22	-	-	HYPH
cord-341050-hnuogpqn	338	23	pH	ph	NN
cord-341050-hnuogpqn	338	24	-	-	HYPH
cord-341050-hnuogpqn	338	25	induced	induce	VBN
cord-341050-hnuogpqn	338	26	membrane	membrane	NN
cord-341050-hnuogpqn	338	27	fusion	fusion	NN
cord-341050-hnuogpqn	338	28	conformation	conformation	NN
cord-341050-hnuogpqn	338	29	Design	design	NN
cord-341050-hnuogpqn	338	30	,	,	,
cord-341050-hnuogpqn	338	31	synthesis	synthesis	NN
cord-341050-hnuogpqn	338	32	,	,	,
cord-341050-hnuogpqn	338	33	and	and	CC
cord-341050-hnuogpqn	338	34	biological	biological	JJ
cord-341050-hnuogpqn	338	35	evaluation	evaluation	NN
cord-341050-hnuogpqn	338	36	of	of	IN
cord-341050-hnuogpqn	338	37	antiviral	antiviral	JJ
cord-341050-hnuogpqn	338	38	agents	agent	NNS
cord-341050-hnuogpqn	338	39	targeting	target	VBG
cord-341050-hnuogpqn	338	40	fl	fl	NNP
cord-341050-hnuogpqn	338	41	avivirus	avivirus	NNP
cord-341050-hnuogpqn	338	42	envelope	envelope	NN
cord-341050-hnuogpqn	338	43	proteins	protein	NNS
cord-341050-hnuogpqn	339	1	A	a	DT
cord-341050-hnuogpqn	339	2	small	small	JJ
cord-341050-hnuogpqn	339	3	molecule	molecule	NN
cord-341050-hnuogpqn	339	4	fusion	fusion	NN
cord-341050-hnuogpqn	339	5	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	339	6	of	of	IN
cord-341050-hnuogpqn	339	7	dengue	dengue	NN
cord-341050-hnuogpqn	339	8	virus	virus	NN
cord-341050-hnuogpqn	340	1	A	a	DT
cord-341050-hnuogpqn	340	2	small	small	JJ
cord-341050-hnuogpqn	340	3	-	-	HYPH
cord-341050-hnuogpqn	340	4	molecule	molecule	NN
cord-341050-hnuogpqn	340	5	dengue	dengue	NN
cord-341050-hnuogpqn	340	6	virus	virus	NN
cord-341050-hnuogpqn	340	7	entry	entry	NN
cord-341050-hnuogpqn	340	8	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	341	1	Antiviral	antiviral	JJ
cord-341050-hnuogpqn	341	2	compounds	compound	NNS
cord-341050-hnuogpqn	341	3	discovered	discover	VBN
cord-341050-hnuogpqn	341	4	by	by	IN
cord-341050-hnuogpqn	341	5	virtual	virtual	JJ
cord-341050-hnuogpqn	341	6	screening	screening	NN
cord-341050-hnuogpqn	341	7	of	of	IN
cord-341050-hnuogpqn	341	8	small	small	JJ
cord-341050-hnuogpqn	341	9	-	-	HYPH
cord-341050-hnuogpqn	341	10	molecule	molecule	NN
cord-341050-hnuogpqn	341	11	libraries	library	NNS
cord-341050-hnuogpqn	341	12	against	against	IN
cord-341050-hnuogpqn	341	13	dengue	dengue	NN
cord-341050-hnuogpqn	341	14	virus	virus	NN
cord-341050-hnuogpqn	341	15	E	e	NN
cord-341050-hnuogpqn	341	16	protein	protein	NN
cord-341050-hnuogpqn	341	17	Sulfated	Sulfated	NNP
cord-341050-hnuogpqn	341	18	Escherichia	Escherichia	NNP
cord-341050-hnuogpqn	341	19	coli	coli	VBZ
cord-341050-hnuogpqn	341	20	K5	K5	NNP
cord-341050-hnuogpqn	341	21	polysaccharide	polysaccharide	NN
cord-341050-hnuogpqn	341	22	derivatives	derivative	NNS
cord-341050-hnuogpqn	341	23	inhibit	inhibit	VBP
cord-341050-hnuogpqn	341	24	dengue	dengue	NN
cord-341050-hnuogpqn	341	25	virus	virus	NN
cord-341050-hnuogpqn	341	26	infection	infection	NN
cord-341050-hnuogpqn	341	27	of	of	IN
cord-341050-hnuogpqn	341	28	human	human	JJ
cord-341050-hnuogpqn	341	29	microvascular	microvascular	JJ
cord-341050-hnuogpqn	341	30	endothelial	endothelial	JJ
cord-341050-hnuogpqn	341	31	cells	cell	NNS
cord-341050-hnuogpqn	341	32	by	by	IN
cord-341050-hnuogpqn	341	33	interacting	interact	VBG
cord-341050-hnuogpqn	341	34	with	with	IN
cord-341050-hnuogpqn	341	35	the	the	DT
cord-341050-hnuogpqn	341	36	viral	viral	JJ
cord-341050-hnuogpqn	341	37	envelope	envelope	NN
cord-341050-hnuogpqn	341	38	protein	protein	NN
cord-341050-hnuogpqn	341	39	E	e	NN
cord-341050-hnuogpqn	341	40	domain	domain	NN
cord-341050-hnuogpqn	341	41	III	iii	CD
cord-341050-hnuogpqn	341	42	Broad	Broad	NNP
cord-341050-hnuogpqn	341	43	-	-	HYPH
cord-341050-hnuogpqn	341	44	spectrum	spectrum	NN
cord-341050-hnuogpqn	341	45	antiviral	antiviral	JJ
cord-341050-hnuogpqn	341	46	activity	activity	NN
cord-341050-hnuogpqn	341	47	of	of	IN
cord-341050-hnuogpqn	341	48	chebulagic	chebulagic	NN
cord-341050-hnuogpqn	341	49	acid	acid	NN
cord-341050-hnuogpqn	341	50	and	and	CC
cord-341050-hnuogpqn	341	51	punicalagin	punicalagin	NN
cord-341050-hnuogpqn	341	52	against	against	IN
cord-341050-hnuogpqn	341	53	viruses	virus	NNS
cord-341050-hnuogpqn	341	54	that	that	WDT
cord-341050-hnuogpqn	341	55	use	use	VBP
cord-341050-hnuogpqn	341	56	glycosaminoglycans	glycosaminoglycan	NNS
cord-341050-hnuogpqn	341	57	for	for	IN
cord-341050-hnuogpqn	341	58	entry	entry	NN
cord-341050-hnuogpqn	341	59	Antiviral	antiviral	JJ
cord-341050-hnuogpqn	341	60	effect	effect	NN
cord-341050-hnuogpqn	341	61	of	of	IN
cord-341050-hnuogpqn	341	62	the	the	DT
cord-341050-hnuogpqn	341	63	heparan	heparan	NN
cord-341050-hnuogpqn	341	64	sulfate	sulfate	NN
cord-341050-hnuogpqn	341	65	mimetic	mimetic	NN
cord-341050-hnuogpqn	341	66	,	,	,
cord-341050-hnuogpqn	341	67	PI-88	PI-88	NNP
cord-341050-hnuogpqn	341	68	,	,	,
cord-341050-hnuogpqn	341	69	against	against	IN
cord-341050-hnuogpqn	341	70	dengue	dengue	NN
cord-341050-hnuogpqn	341	71	and	and	CC
cord-341050-hnuogpqn	341	72	encephalitic	encephalitic	NNP
cord-341050-hnuogpqn	341	73	fl	fl	NNP
cord-341050-hnuogpqn	341	74	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	342	1	Antiviral	antiviral	JJ
cord-341050-hnuogpqn	342	2	activity	activity	NN
cord-341050-hnuogpqn	342	3	against	against	IN
cord-341050-hnuogpqn	342	4	dengue	dengue	NN
cord-341050-hnuogpqn	342	5	virus	virus	NN
cord-341050-hnuogpqn	342	6	of	of	IN
cord-341050-hnuogpqn	342	7	diverse	diverse	JJ
cord-341050-hnuogpqn	342	8	classes	class	NNS
cord-341050-hnuogpqn	342	9	of	of	IN
cord-341050-hnuogpqn	342	10	algal	algal	JJ
cord-341050-hnuogpqn	342	11	sulfated	sulfate	VBN
cord-341050-hnuogpqn	342	12	polysaccharides	polysaccharide	NNS
cord-341050-hnuogpqn	342	13	Carbohydrate	carbohydrate	NN
cord-341050-hnuogpqn	342	14	-	-	HYPH
cord-341050-hnuogpqn	342	15	binding	bind	VBG
cord-341050-hnuogpqn	342	16	agents	agent	NNS
cord-341050-hnuogpqn	342	17	:	:	:
cord-341050-hnuogpqn	342	18	a	a	DT
cord-341050-hnuogpqn	342	19	potential	potential	JJ
cord-341050-hnuogpqn	342	20	future	future	JJ
cord-341050-hnuogpqn	342	21	cornerstone	cornerstone	NN
cord-341050-hnuogpqn	342	22	for	for	IN
cord-341050-hnuogpqn	342	23	the	the	DT
cord-341050-hnuogpqn	342	24	chemotherapy	chemotherapy	NN
cord-341050-hnuogpqn	342	25	of	of	IN
cord-341050-hnuogpqn	342	26	enveloped	envelop	VBN
cord-341050-hnuogpqn	342	27	viruses	virus	NNS
cord-341050-hnuogpqn	342	28	?	?	.
cord-341050-hnuogpqn	343	1	Antiretroviral	antiretroviral	JJ
cord-341050-hnuogpqn	343	2	treatment	treatment	NN
cord-341050-hnuogpqn	343	3	of	of	IN
cord-341050-hnuogpqn	343	4	adult	adult	NN
cord-341050-hnuogpqn	343	5	HIV	HIV	NNP
cord-341050-hnuogpqn	343	6	infection	infection	NN
cord-341050-hnuogpqn	343	7	:	:	:
cord-341050-hnuogpqn	344	1	2014	2014	CD
cord-341050-hnuogpqn	344	2	recommendations	recommendation	NNS
cord-341050-hnuogpqn	344	3	of	of	IN
cord-341050-hnuogpqn	344	4	the	the	DT
cord-341050-hnuogpqn	344	5	International	International	NNP
cord-341050-hnuogpqn	344	6	Antiviral	Antiviral	NNP
cord-341050-hnuogpqn	344	7	Society	Society	NNP
cord-341050-hnuogpqn	344	8	-	-	HYPH
cord-341050-hnuogpqn	344	9	USA	USA	NNP
cord-341050-hnuogpqn	344	10	Panel	Panel	NNP
cord-341050-hnuogpqn	344	11	Protease	Protease	NNP
cord-341050-hnuogpqn	344	12	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	344	13	as	as	IN
cord-341050-hnuogpqn	344	14	antiviral	antiviral	JJ
cord-341050-hnuogpqn	344	15	agents	agent	NNS
cord-341050-hnuogpqn	344	16	Discovery	Discovery	NNP
cord-341050-hnuogpqn	344	17	and	and	CC
cord-341050-hnuogpqn	344	18	development	development	NN
cord-341050-hnuogpqn	344	19	of	of	IN
cord-341050-hnuogpqn	344	20	VX-950	vx-950	NN
cord-341050-hnuogpqn	344	21	,	,	,
cord-341050-hnuogpqn	344	22	a	a	DT
cord-341050-hnuogpqn	344	23	novel	novel	NN
cord-341050-hnuogpqn	344	24	,	,	,
cord-341050-hnuogpqn	344	25	covalent	covalent	JJ
cord-341050-hnuogpqn	344	26	,	,	,
cord-341050-hnuogpqn	344	27	and	and	CC
cord-341050-hnuogpqn	344	28	reversible	reversible	JJ
cord-341050-hnuogpqn	344	29	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	344	30	of	of	IN
cord-341050-hnuogpqn	344	31	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	344	32	C	C	NNP
cord-341050-hnuogpqn	344	33	virus	virus	NN
cord-341050-hnuogpqn	344	34	NS3.4A	ns3.4a	NN
cord-341050-hnuogpqn	344	35	serine	serine	NN
cord-341050-hnuogpqn	344	36	protease	protease	NN
cord-341050-hnuogpqn	344	37	Preclinical	Preclinical	NNP
cord-341050-hnuogpqn	344	38	profi	profi	NNP
cord-341050-hnuogpqn	344	39	le	le	FW
cord-341050-hnuogpqn	344	40	of	of	IN
cord-341050-hnuogpqn	344	41	VX-950	VX-950	NNP
cord-341050-hnuogpqn	344	42	,	,	,
cord-341050-hnuogpqn	344	43	a	a	DT
cord-341050-hnuogpqn	344	44	potent	potent	JJ
cord-341050-hnuogpqn	344	45	,	,	,
cord-341050-hnuogpqn	344	46	selective	selective	JJ
cord-341050-hnuogpqn	344	47	,	,	,
cord-341050-hnuogpqn	344	48	and	and	CC
cord-341050-hnuogpqn	344	49	orally	orally	RB
cord-341050-hnuogpqn	344	50	bioavailable	bioavailable	JJ
cord-341050-hnuogpqn	344	51	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	344	52	of	of	IN
cord-341050-hnuogpqn	344	53	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	344	54	C	C	NNP
cord-341050-hnuogpqn	344	55	virus	virus	NN
cord-341050-hnuogpqn	344	56	NS3	ns3	RB
cord-341050-hnuogpqn	344	57	-	-	HYPH
cord-341050-hnuogpqn	344	58	4A	4a	CD
cord-341050-hnuogpqn	344	59	serine	serine	NN
cord-341050-hnuogpqn	344	60	protease	protease	NN
cord-341050-hnuogpqn	345	1	Both	both	DT
cord-341050-hnuogpqn	345	2	nonstructural	nonstructural	JJ
cord-341050-hnuogpqn	345	3	proteins	protein	NNS
cord-341050-hnuogpqn	346	1	NS2B	NS2B	NNP
cord-341050-hnuogpqn	346	2	and	and	CC
cord-341050-hnuogpqn	346	3	NS3	ns3	RB
cord-341050-hnuogpqn	346	4	are	be	VBP
cord-341050-hnuogpqn	346	5	required	require	VBN
cord-341050-hnuogpqn	346	6	for	for	IN
cord-341050-hnuogpqn	346	7	the	the	DT
cord-341050-hnuogpqn	346	8	proteolytic	proteolytic	JJ
cord-341050-hnuogpqn	346	9	processing	processing	NN
cord-341050-hnuogpqn	346	10	of	of	IN
cord-341050-hnuogpqn	346	11	dengue	dengue	NN
cord-341050-hnuogpqn	346	12	virus	virus	NN
cord-341050-hnuogpqn	346	13	nonstructural	nonstructural	JJ
cord-341050-hnuogpqn	346	14	proteins	protein	NNS
cord-341050-hnuogpqn	346	15	NMR	NMR	NNP
cord-341050-hnuogpqn	346	16	analysis	analysis	NN
cord-341050-hnuogpqn	346	17	of	of	IN
cord-341050-hnuogpqn	346	18	a	a	DT
cord-341050-hnuogpqn	346	19	novel	novel	NN
cord-341050-hnuogpqn	346	20	enzymatically	enzymatically	RB
cord-341050-hnuogpqn	346	21	active	active	JJ
cord-341050-hnuogpqn	346	22	unlinked	unlinked	JJ
cord-341050-hnuogpqn	346	23	dengue	dengue	NN
cord-341050-hnuogpqn	346	24	NS2B	ns2b	NN
cord-341050-hnuogpqn	346	25	-	-	:
cord-341050-hnuogpqn	346	26	NS3	ns3	RB
cord-341050-hnuogpqn	346	27	protease	protease	NN
cord-341050-hnuogpqn	346	28	complex	complex	JJ
cord-341050-hnuogpqn	346	29	High	high	JJ
cord-341050-hnuogpqn	346	30	-	-	HYPH
cord-341050-hnuogpqn	346	31	throughput	throughput	NN
cord-341050-hnuogpqn	346	32	screening	screening	NN
cord-341050-hnuogpqn	346	33	of	of	IN
cord-341050-hnuogpqn	346	34	low	low	JJ
cord-341050-hnuogpqn	346	35	molecular	molecular	JJ
cord-341050-hnuogpqn	346	36	weight	weight	NN
cord-341050-hnuogpqn	347	1	NS3-NS4A	NS3-NS4A	NNP
cord-341050-hnuogpqn	347	2	protease	protease	NN
cord-341050-hnuogpqn	347	3	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	347	4	using	use	VBG
cord-341050-hnuogpqn	347	5	a	a	DT
cord-341050-hnuogpqn	347	6	fl	fl	NNP
cord-341050-hnuogpqn	347	7	uorescence	uorescence	NN
cord-341050-hnuogpqn	347	8	resonance	resonance	NN
cord-341050-hnuogpqn	347	9	energy	energy	NN
cord-341050-hnuogpqn	347	10	transfer	transfer	NN
cord-341050-hnuogpqn	347	11	substrate	substrate	NN
cord-341050-hnuogpqn	347	12	Establishment	Establishment	NNP
cord-341050-hnuogpqn	347	13	of	of	IN
cord-341050-hnuogpqn	347	14	an	an	DT
cord-341050-hnuogpqn	347	15	in	in	FW
cord-341050-hnuogpqn	347	16	vitro	vitro	FW
cord-341050-hnuogpqn	347	17	assay	assay	NN
cord-341050-hnuogpqn	347	18	system	system	NN
cord-341050-hnuogpqn	347	19	for	for	IN
cord-341050-hnuogpqn	347	20	screening	screen	VBG
cord-341050-hnuogpqn	347	21	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	347	22	C	C	NNP
cord-341050-hnuogpqn	347	23	virus	virus	NN
cord-341050-hnuogpqn	347	24	protease	protease	NN
cord-341050-hnuogpqn	347	25	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	347	26	using	use	VBG
cord-341050-hnuogpqn	347	27	high	high	JJ
cord-341050-hnuogpqn	347	28	performance	performance	NN
cord-341050-hnuogpqn	347	29	liquid	liquid	NN
cord-341050-hnuogpqn	347	30	chromatography	chromatography	NN
cord-341050-hnuogpqn	347	31	A	a	DT
cord-341050-hnuogpqn	347	32	novel	novel	JJ
cord-341050-hnuogpqn	347	33	high	high	JJ
cord-341050-hnuogpqn	347	34	throughput	throughput	NN
cord-341050-hnuogpqn	347	35	screening	screening	NN
cord-341050-hnuogpqn	347	36	assay	assay	NN
cord-341050-hnuogpqn	347	37	for	for	IN
cord-341050-hnuogpqn	347	38	HCV	HCV	NNP
cord-341050-hnuogpqn	347	39	NS3	NS3	NNP
cord-341050-hnuogpqn	347	40	serine	serine	NN
cord-341050-hnuogpqn	347	41	protease	protease	NN
cord-341050-hnuogpqn	347	42	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	347	43	Non	non	JJ
cord-341050-hnuogpqn	347	44	-	-	JJ
cord-341050-hnuogpqn	347	45	peptide	peptide	JJ
cord-341050-hnuogpqn	347	46	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	347	47	of	of	IN
cord-341050-hnuogpqn	347	48	HCV	HCV	NNP
cord-341050-hnuogpqn	347	49	serine	serine	NN
cord-341050-hnuogpqn	347	50	proteinase	proteinase	NN
cord-341050-hnuogpqn	347	51	The	the	DT
cord-341050-hnuogpqn	347	52	fl	fl	NNP
cord-341050-hnuogpqn	347	53	avivirus	avivirus	NN
cord-341050-hnuogpqn	347	54	protease	protease	NN
cord-341050-hnuogpqn	347	55	as	as	IN
cord-341050-hnuogpqn	347	56	a	a	DT
cord-341050-hnuogpqn	347	57	target	target	NN
cord-341050-hnuogpqn	347	58	for	for	IN
cord-341050-hnuogpqn	347	59	drug	drug	NN
cord-341050-hnuogpqn	347	60	discovery	discovery	NN
cord-341050-hnuogpqn	348	1	Structural	structural	JJ
cord-341050-hnuogpqn	348	2	evidence	evidence	NN
cord-341050-hnuogpqn	348	3	for	for	IN
cord-341050-hnuogpqn	348	4	regulation	regulation	NN
cord-341050-hnuogpqn	348	5	and	and	CC
cord-341050-hnuogpqn	348	6	specifi	specifi	NN
cord-341050-hnuogpqn	348	7	city	city	NN
cord-341050-hnuogpqn	348	8	of	of	IN
cord-341050-hnuogpqn	348	9	fl	fl	NNP
cord-341050-hnuogpqn	348	10	aviviral	aviviral	JJ
cord-341050-hnuogpqn	348	11	proteases	protease	NNS
cord-341050-hnuogpqn	348	12	and	and	CC
cord-341050-hnuogpqn	348	13	evolution	evolution	NN
cord-341050-hnuogpqn	348	14	of	of	IN
cord-341050-hnuogpqn	348	15	the	the	DT
cord-341050-hnuogpqn	348	16	Flaviviridae	Flaviviridae	NNP
cord-341050-hnuogpqn	348	17	fold	fold	NN
cord-341050-hnuogpqn	348	18	Activity	activity	NN
cord-341050-hnuogpqn	348	19	of	of	IN
cord-341050-hnuogpqn	348	20	recombinant	recombinant	JJ
cord-341050-hnuogpqn	348	21	dengue	dengue	NN
cord-341050-hnuogpqn	348	22	2	2	CD
cord-341050-hnuogpqn	348	23	virus	virus	NN
cord-341050-hnuogpqn	348	24	NS3	ns3	RB
cord-341050-hnuogpqn	348	25	protease	protease	VBP
cord-341050-hnuogpqn	348	26	in	in	IN
cord-341050-hnuogpqn	348	27	the	the	DT
cord-341050-hnuogpqn	348	28	presence	presence	NN
cord-341050-hnuogpqn	348	29	of	of	IN
cord-341050-hnuogpqn	348	30	a	a	DT
cord-341050-hnuogpqn	348	31	truncated	truncated	JJ
cord-341050-hnuogpqn	348	32	NS2B	NS2B	NNP
cord-341050-hnuogpqn	348	33	co	co	NN
cord-341050-hnuogpqn	348	34	-	-	NN
cord-341050-hnuogpqn	348	35	factor	factor	NN
cord-341050-hnuogpqn	348	36	,	,	,
cord-341050-hnuogpqn	348	37	small	small	JJ
cord-341050-hnuogpqn	348	38	peptide	peptide	NN
cord-341050-hnuogpqn	348	39	substrates	substrate	NNS
cord-341050-hnuogpqn	348	40	,	,	,
cord-341050-hnuogpqn	348	41	and	and	CC
cord-341050-hnuogpqn	348	42	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	348	43	Investigators	investigator	NNS
cord-341050-hnuogpqn	348	44	of	of	IN
cord-341050-hnuogpqn	348	45	The	the	DT
cord-341050-hnuogpqn	348	46	Multicenter	Multicenter	NNP
cord-341050-hnuogpqn	348	47	Study	Study	NNP
cord-341050-hnuogpqn	348	48	of	of	IN
cord-341050-hnuogpqn	348	49	Perioperative	Perioperative	NNP
cord-341050-hnuogpqn	348	50	Ischemia	Ischemia	NNP
cord-341050-hnuogpqn	348	51	Research	Research	NNP
cord-341050-hnuogpqn	348	52	Group	Group	NNP
cord-341050-hnuogpqn	348	53	,	,	,
cord-341050-hnuogpqn	348	54	Ischemia	Ischemia	NNP
cord-341050-hnuogpqn	348	55	Research	Research	NNP
cord-341050-hnuogpqn	348	56	,	,	,
cord-341050-hnuogpqn	348	57	and	and	CC
cord-341050-hnuogpqn	348	58	Education	Education	NNP
cord-341050-hnuogpqn	348	59	Foundation	Foundation	NNP
cord-341050-hnuogpqn	348	60	(	(	-LRB-
cord-341050-hnuogpqn	348	61	2007	2007	CD
cord-341050-hnuogpqn	348	62	)	)	-RRB-
cord-341050-hnuogpqn	348	63	Mortality	mortality	NN
cord-341050-hnuogpqn	348	64	associated	associate	VBN
cord-341050-hnuogpqn	348	65	with	with	IN
cord-341050-hnuogpqn	348	66	aprotinin	aprotinin	NNS
cord-341050-hnuogpqn	348	67	during	during	IN
cord-341050-hnuogpqn	348	68	5	5	CD
cord-341050-hnuogpqn	348	69	years	year	NNS
cord-341050-hnuogpqn	348	70	following	follow	VBG
cord-341050-hnuogpqn	348	71	coronary	coronary	JJ
cord-341050-hnuogpqn	348	72	artery	artery	NN
cord-341050-hnuogpqn	348	73	bypass	bypass	NN
cord-341050-hnuogpqn	348	74	graft	graft	NN
cord-341050-hnuogpqn	348	75	surgery	surgery	NN
cord-341050-hnuogpqn	348	76	Discovery	Discovery	NNP
cord-341050-hnuogpqn	348	77	of	of	IN
cord-341050-hnuogpqn	348	78	a	a	DT
cord-341050-hnuogpqn	348	79	non	non	JJ
cord-341050-hnuogpqn	348	80	-	-	JJ
cord-341050-hnuogpqn	348	81	peptidic	peptidic	JJ
cord-341050-hnuogpqn	348	82	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	348	83	of	of	IN
cord-341050-hnuogpqn	348	84	West	West	NNP
cord-341050-hnuogpqn	348	85	Nile	Nile	NNP
cord-341050-hnuogpqn	348	86	virus	virus	NN
cord-341050-hnuogpqn	348	87	NS3	ns3	RB
cord-341050-hnuogpqn	348	88	protease	protease	NN
cord-341050-hnuogpqn	348	89	by	by	IN
cord-341050-hnuogpqn	348	90	high	high	JJ
cord-341050-hnuogpqn	348	91	-	-	HYPH
cord-341050-hnuogpqn	348	92	throughput	throughput	NN
cord-341050-hnuogpqn	348	93	docking	docking	NN
cord-341050-hnuogpqn	348	94	Identifi	Identifi	NNP
cord-341050-hnuogpqn	348	95	cation	cation	NN
cord-341050-hnuogpqn	348	96	and	and	CC
cord-341050-hnuogpqn	348	97	biochemical	biochemical	JJ
cord-341050-hnuogpqn	348	98	characterization	characterization	NN
cord-341050-hnuogpqn	348	99	of	of	IN
cord-341050-hnuogpqn	348	100	small	small	JJ
cord-341050-hnuogpqn	348	101	-	-	HYPH
cord-341050-hnuogpqn	348	102	molecule	molecule	NN
cord-341050-hnuogpqn	348	103	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	348	104	of	of	IN
cord-341050-hnuogpqn	348	105	West	West	NNP
cord-341050-hnuogpqn	348	106	Nile	Nile	NNP
cord-341050-hnuogpqn	348	107	virus	virus	NN
cord-341050-hnuogpqn	348	108	serine	serine	NN
cord-341050-hnuogpqn	348	109	protease	protease	NN
cord-341050-hnuogpqn	348	110	by	by	IN
cord-341050-hnuogpqn	348	111	a	a	DT
cord-341050-hnuogpqn	348	112	high	high	JJ
cord-341050-hnuogpqn	348	113	-	-	HYPH
cord-341050-hnuogpqn	348	114	throughput	throughput	NN
cord-341050-hnuogpqn	348	115	screen	screen	NN
cord-341050-hnuogpqn	348	116	Characterization	characterization	NN
cord-341050-hnuogpqn	348	117	of	of	IN
cord-341050-hnuogpqn	348	118	the	the	DT
cord-341050-hnuogpqn	348	119	West	West	NNP
cord-341050-hnuogpqn	348	120	Nile	Nile	NNP
cord-341050-hnuogpqn	348	121	virus	virus	NN
cord-341050-hnuogpqn	348	122	protease	protease	NN
cord-341050-hnuogpqn	348	123	substrate	substrate	NN
cord-341050-hnuogpqn	348	124	specifi	specifi	VBN
cord-341050-hnuogpqn	348	125	city	city	NN
cord-341050-hnuogpqn	348	126	and	and	CC
cord-341050-hnuogpqn	348	127	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	348	128	Synthesis	Synthesis	NNP
cord-341050-hnuogpqn	348	129	and	and	CC
cord-341050-hnuogpqn	348	130	in	in	IN
cord-341050-hnuogpqn	348	131	vitro	vitro	FW
cord-341050-hnuogpqn	348	132	evaluation	evaluation	NN
cord-341050-hnuogpqn	348	133	of	of	IN
cord-341050-hnuogpqn	348	134	West	West	NNP
cord-341050-hnuogpqn	348	135	Nile	Nile	NNP
cord-341050-hnuogpqn	348	136	virus	virus	NN
cord-341050-hnuogpqn	348	137	protease	protease	NN
cord-341050-hnuogpqn	348	138	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	348	139	based	base	VBN
cord-341050-hnuogpqn	348	140	on	on	IN
cord-341050-hnuogpqn	348	141	the	the	DT
cord-341050-hnuogpqn	348	142	2-{6	2-{6	CD
cord-341050-hnuogpqn	348	143	Structure	structure	NN
cord-341050-hnuogpqn	348	144	-	-	HYPH
cord-341050-hnuogpqn	348	145	activity	activity	NN
cord-341050-hnuogpqn	348	146	relationship	relationship	NN
cord-341050-hnuogpqn	348	147	and	and	CC
cord-341050-hnuogpqn	348	148	improved	improve	VBN
cord-341050-hnuogpqn	348	149	hydrolytic	hydrolytic	JJ
cord-341050-hnuogpqn	348	150	stability	stability	NN
cord-341050-hnuogpqn	348	151	of	of	IN
cord-341050-hnuogpqn	348	152	pyrazole	pyrazole	NN
cord-341050-hnuogpqn	348	153	derivatives	derivative	NNS
cord-341050-hnuogpqn	348	154	that	that	WDT
cord-341050-hnuogpqn	348	155	are	be	VBP
cord-341050-hnuogpqn	348	156	allosteric	allosteric	JJ
cord-341050-hnuogpqn	348	157	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	348	158	of	of	IN
cord-341050-hnuogpqn	348	159	West	West	NNP
cord-341050-hnuogpqn	348	160	Nile	Nile	NNP
cord-341050-hnuogpqn	348	161	Virus	Virus	NNP
cord-341050-hnuogpqn	348	162	NS2B	NS2B	NNP
cord-341050-hnuogpqn	348	163	-	-	,
cord-341050-hnuogpqn	348	164	NS3	ns3	RB
cord-341050-hnuogpqn	348	165	proteinase	proteinase	NN
cord-341050-hnuogpqn	348	166	Inhibitors	Inhibitors	NNP
cord-341050-hnuogpqn	348	167	of	of	IN
cord-341050-hnuogpqn	348	168	Dengue	Dengue	NNP
cord-341050-hnuogpqn	348	169	virus	virus	NN
cord-341050-hnuogpqn	348	170	and	and	CC
cord-341050-hnuogpqn	348	171	West	West	NNP
cord-341050-hnuogpqn	348	172	Nile	Nile	NNP
cord-341050-hnuogpqn	348	173	virus	virus	NN
cord-341050-hnuogpqn	348	174	proteases	protease	NNS
cord-341050-hnuogpqn	348	175	based	base	VBN
cord-341050-hnuogpqn	348	176	on	on	IN
cord-341050-hnuogpqn	348	177	the	the	DT
cord-341050-hnuogpqn	348	178	aminobenzamide	aminobenzamide	JJ
cord-341050-hnuogpqn	348	179	scaffold	scaffold	NN
cord-341050-hnuogpqn	348	180	Synthesis	Synthesis	NNP
cord-341050-hnuogpqn	348	181	and	and	CC
cord-341050-hnuogpqn	348	182	in	in	IN
cord-341050-hnuogpqn	348	183	vitro	vitro	FW
cord-341050-hnuogpqn	348	184	evaluation	evaluation	NN
cord-341050-hnuogpqn	348	185	of	of	IN
cord-341050-hnuogpqn	348	186	West	West	NNP
cord-341050-hnuogpqn	348	187	Nile	Nile	NNP
cord-341050-hnuogpqn	348	188	virus	virus	NN
cord-341050-hnuogpqn	348	189	protease	protease	NN
cord-341050-hnuogpqn	348	190	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	348	191	based	base	VBN
cord-341050-hnuogpqn	348	192	on	on	IN
cord-341050-hnuogpqn	348	193	the	the	DT
cord-341050-hnuogpqn	348	194	1,3,4,5-tetrasubstituted	1,3,4,5-tetrasubstituted	JJ
cord-341050-hnuogpqn	348	195	1H	1h	CD
cord-341050-hnuogpqn	348	196	-	-	HYPH
cord-341050-hnuogpqn	348	197	pyrrol-2(5H)-one	pyrrol-2(5h)-one	NN
cord-341050-hnuogpqn	348	198	scaffold	scaffold	NN
cord-341050-hnuogpqn	348	199	Design	design	NN
cord-341050-hnuogpqn	348	200	,	,	,
cord-341050-hnuogpqn	348	201	synthesis	synthesis	NN
cord-341050-hnuogpqn	348	202	and	and	CC
cord-341050-hnuogpqn	348	203	characterization	characterization	NN
cord-341050-hnuogpqn	348	204	of	of	IN
cord-341050-hnuogpqn	348	205	novel	novel	NN
cord-341050-hnuogpqn	348	206	1,2-benzisothiazol-3(2H)-one	1,2-benzisothiazol-3(2h)-one	CD
cord-341050-hnuogpqn	348	207	and	and	CC
cord-341050-hnuogpqn	348	208	1,3,4-oxadiazole	1,3,4-oxadiazole	CD
cord-341050-hnuogpqn	348	209	hybrid	hybrid	JJ
cord-341050-hnuogpqn	348	210	derivatives	derivative	NNS
cord-341050-hnuogpqn	348	211	:	:	:
cord-341050-hnuogpqn	348	212	potent	potent	JJ
cord-341050-hnuogpqn	348	213	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	348	214	of	of	IN
cord-341050-hnuogpqn	348	215	Dengue	Dengue	NNP
cord-341050-hnuogpqn	348	216	and	and	CC
cord-341050-hnuogpqn	348	217	West	West	NNP
cord-341050-hnuogpqn	348	218	Nile	Nile	NNP
cord-341050-hnuogpqn	348	219	virus	virus	NN
cord-341050-hnuogpqn	348	220	NS2B	NS2B	NNP
cord-341050-hnuogpqn	348	221	/	/	,
cord-341050-hnuogpqn	348	222	NS3	ns3	RB
cord-341050-hnuogpqn	348	223	proteases	protease	NNS
cord-341050-hnuogpqn	349	1	Small	small	JJ
cord-341050-hnuogpqn	349	2	molecule	molecule	NN
cord-341050-hnuogpqn	349	3	pan	pan	NN
cord-341050-hnuogpqn	349	4	-	-	HYPH
cord-341050-hnuogpqn	349	5	dengue	dengue	NN
cord-341050-hnuogpqn	349	6	and	and	CC
cord-341050-hnuogpqn	349	7	West	West	NNP
cord-341050-hnuogpqn	349	8	Nile	Nile	NNP
cord-341050-hnuogpqn	349	9	virus	virus	NN
cord-341050-hnuogpqn	350	1	NS3	ns3	RB
cord-341050-hnuogpqn	350	2	protease	protease	NN
cord-341050-hnuogpqn	350	3	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	351	1	Flexibility	flexibility	NN
cord-341050-hnuogpqn	351	2	between	between	IN
cord-341050-hnuogpqn	351	3	the	the	DT
cord-341050-hnuogpqn	351	4	protease	protease	NN
cord-341050-hnuogpqn	351	5	and	and	CC
cord-341050-hnuogpqn	351	6	helicase	helicase	NN
cord-341050-hnuogpqn	351	7	domains	domain	NNS
cord-341050-hnuogpqn	351	8	of	of	IN
cord-341050-hnuogpqn	351	9	the	the	DT
cord-341050-hnuogpqn	351	10	dengue	dengue	NN
cord-341050-hnuogpqn	351	11	virus	virus	NN
cord-341050-hnuogpqn	351	12	NS3	ns3	RB
cord-341050-hnuogpqn	351	13	protein	protein	NN
cord-341050-hnuogpqn	351	14	conferred	confer	VBN
cord-341050-hnuogpqn	351	15	by	by	IN
cord-341050-hnuogpqn	351	16	the	the	DT
cord-341050-hnuogpqn	351	17	linker	linker	NN
cord-341050-hnuogpqn	351	18	region	region	NN
cord-341050-hnuogpqn	351	19	and	and	CC
cord-341050-hnuogpqn	351	20	its	-PRON-	PRP$
cord-341050-hnuogpqn	351	21	functional	functional	JJ
cord-341050-hnuogpqn	351	22	implications	implication	NNS
cord-341050-hnuogpqn	351	23	Structure	Structure	NNP
cord-341050-hnuogpqn	351	24	of	of	IN
cord-341050-hnuogpqn	351	25	West	West	NNP
cord-341050-hnuogpqn	351	26	Nile	Nile	NNP
cord-341050-hnuogpqn	351	27	virus	virus	NN
cord-341050-hnuogpqn	352	1	NS3	ns3	RB
cord-341050-hnuogpqn	352	2	protease	protease	NN
cord-341050-hnuogpqn	352	3	:	:	:
cord-341050-hnuogpqn	352	4	ligand	ligand	NN
cord-341050-hnuogpqn	352	5	stabilization	stabilization	NN
cord-341050-hnuogpqn	352	6	of	of	IN
cord-341050-hnuogpqn	352	7	the	the	DT
cord-341050-hnuogpqn	352	8	catalytic	catalytic	JJ
cord-341050-hnuogpqn	352	9	conformation	conformation	NN
cord-341050-hnuogpqn	353	1	A	a	DT
cord-341050-hnuogpqn	353	2	single	single	JJ
cord-341050-hnuogpqn	353	3	positively	positively	RB
cord-341050-hnuogpqn	353	4	selected	select	VBN
cord-341050-hnuogpqn	353	5	West	West	NNP
cord-341050-hnuogpqn	353	6	Nile	Nile	NNP
cord-341050-hnuogpqn	353	7	viral	viral	JJ
cord-341050-hnuogpqn	353	8	mutation	mutation	NN
cord-341050-hnuogpqn	353	9	confers	confer	VBZ
cord-341050-hnuogpqn	353	10	increased	increase	VBN
cord-341050-hnuogpqn	353	11	virogenesis	virogenesis	NN
cord-341050-hnuogpqn	353	12	in	in	IN
cord-341050-hnuogpqn	353	13	American	american	JJ
cord-341050-hnuogpqn	353	14	crows	crow	VBZ
cord-341050-hnuogpqn	353	15	Viral	viral	JJ
cord-341050-hnuogpqn	353	16	determinants	determinant	NNS
cord-341050-hnuogpqn	353	17	in	in	IN
cord-341050-hnuogpqn	353	18	the	the	DT
cord-341050-hnuogpqn	353	19	NS3	ns3	NN
cord-341050-hnuogpqn	353	20	helicase	helicase	NN
cord-341050-hnuogpqn	353	21	and	and	CC
cord-341050-hnuogpqn	353	22	2	2	CD
cord-341050-hnuogpqn	353	23	K	k	NN
cord-341050-hnuogpqn	353	24	peptide	peptide	NN
cord-341050-hnuogpqn	353	25	that	that	WDT
cord-341050-hnuogpqn	353	26	promote	promote	VBP
cord-341050-hnuogpqn	353	27	West	West	NNP
cord-341050-hnuogpqn	353	28	Nile	Nile	NNP
cord-341050-hnuogpqn	353	29	virus	virus	NN
cord-341050-hnuogpqn	353	30	resistance	resistance	NN
cord-341050-hnuogpqn	353	31	to	to	IN
cord-341050-hnuogpqn	353	32	antiviral	antiviral	JJ
cord-341050-hnuogpqn	353	33	action	action	NN
cord-341050-hnuogpqn	353	34	of	of	IN
cord-341050-hnuogpqn	353	35	2′,5′-oligoadenylate	2′,5′-oligoadenylate	CD
cord-341050-hnuogpqn	353	36	synthetase	synthetase	NN
cord-341050-hnuogpqn	353	37	1b	1b	CD
cord-341050-hnuogpqn	353	38	Purifi	Purifi	NNP
cord-341050-hnuogpqn	353	39	cation	cation	NN
cord-341050-hnuogpqn	353	40	and	and	CC
cord-341050-hnuogpqn	353	41	characterization	characterization	NN
cord-341050-hnuogpqn	353	42	of	of	IN
cord-341050-hnuogpqn	353	43	West	West	NNP
cord-341050-hnuogpqn	353	44	Nile	Nile	NNP
cord-341050-hnuogpqn	353	45	virus	virus	NN
cord-341050-hnuogpqn	353	46	nucleoside	nucleoside	NN
cord-341050-hnuogpqn	353	47	triphosphatase	triphosphatase	NN
cord-341050-hnuogpqn	353	48	(	(	-LRB-
cord-341050-hnuogpqn	353	49	NTPase)/helicase	ntpase)/helicase	NN
cord-341050-hnuogpqn	353	50	:	:	:
cord-341050-hnuogpqn	353	51	evidence	evidence	NN
cord-341050-hnuogpqn	353	52	for	for	IN
cord-341050-hnuogpqn	353	53	dissociation	dissociation	NN
cord-341050-hnuogpqn	353	54	of	of	IN
cord-341050-hnuogpqn	353	55	the	the	DT
cord-341050-hnuogpqn	353	56	NTPase	NTPase	NNP
cord-341050-hnuogpqn	353	57	and	and	CC
cord-341050-hnuogpqn	353	58	helicase	helicase	NNP
cord-341050-hnuogpqn	353	59	activities	activity	NNS
cord-341050-hnuogpqn	353	60	of	of	IN
cord-341050-hnuogpqn	353	61	the	the	DT
cord-341050-hnuogpqn	353	62	enzyme	enzyme	NN
cord-341050-hnuogpqn	353	63	Direct	Direct	NNP
cord-341050-hnuogpqn	353	64	fl	fl	NNP
cord-341050-hnuogpqn	353	65	uorometric	uorometric	JJ
cord-341050-hnuogpqn	353	66	measurement	measurement	NN
cord-341050-hnuogpqn	353	67	of	of	IN
cord-341050-hnuogpqn	353	68	hepatitis	hepatitis	NNP
cord-341050-hnuogpqn	353	69	C	C	NNP
cord-341050-hnuogpqn	353	70	virus	virus	NN
cord-341050-hnuogpqn	353	71	helicase	helicase	NN
cord-341050-hnuogpqn	353	72	activity	activity	NN
cord-341050-hnuogpqn	353	73	Identifi	Identifi	NNP
cord-341050-hnuogpqn	353	74	cation	cation	NN
cord-341050-hnuogpqn	353	75	and	and	CC
cord-341050-hnuogpqn	353	76	analysis	analysis	NN
cord-341050-hnuogpqn	353	77	of	of	IN
cord-341050-hnuogpqn	353	78	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	353	79	targeting	target	VBG
cord-341050-hnuogpqn	353	80	the	the	DT
cord-341050-hnuogpqn	353	81	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	353	82	C	C	NNP
cord-341050-hnuogpqn	353	83	virus	virus	NN
cord-341050-hnuogpqn	353	84	NS3	ns3	RB
cord-341050-hnuogpqn	353	85	helicase	helicase	NNP
cord-341050-hnuogpqn	353	86	Identifi	Identifi	NNP
cord-341050-hnuogpqn	353	87	cation	cation	NN
cord-341050-hnuogpqn	353	88	and	and	CC
cord-341050-hnuogpqn	353	89	analysis	analysis	NN
cord-341050-hnuogpqn	353	90	of	of	IN
cord-341050-hnuogpqn	353	91	hepatitis	hepatitis	NNP
cord-341050-hnuogpqn	353	92	C	C	NNP
cord-341050-hnuogpqn	353	93	virus	virus	NN
cord-341050-hnuogpqn	353	94	NS3	ns3	RB
cord-341050-hnuogpqn	353	95	helicase	helicase	NN
cord-341050-hnuogpqn	353	96	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	353	97	using	use	VBG
cord-341050-hnuogpqn	353	98	nucleic	nucleic	JJ
cord-341050-hnuogpqn	353	99	acid	acid	NN
cord-341050-hnuogpqn	353	100	binding	bind	VBG
cord-341050-hnuogpqn	353	101	assays	assay	NNS
cord-341050-hnuogpqn	353	102	High	high	JJ
cord-341050-hnuogpqn	353	103	-	-	HYPH
cord-341050-hnuogpqn	353	104	throughput	throughput	NN
cord-341050-hnuogpqn	353	105	screening	screening	NN
cord-341050-hnuogpqn	353	106	assay	assay	NN
cord-341050-hnuogpqn	353	107	of	of	IN
cord-341050-hnuogpqn	353	108	hepatitis	hepatitis	NNP
cord-341050-hnuogpqn	353	109	C	C	NNP
cord-341050-hnuogpqn	353	110	virus	virus	NN
cord-341050-hnuogpqn	353	111	helicase	helicase	NN
cord-341050-hnuogpqn	353	112	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	353	113	using	use	VBG
cord-341050-hnuogpqn	353	114	fl	fl	NNP
cord-341050-hnuogpqn	353	115	uorescence	uorescence	NN
cord-341050-hnuogpqn	353	116	-	-	HYPH
cord-341050-hnuogpqn	353	117	quenching	quenching	NN
cord-341050-hnuogpqn	353	118	phenomenon	phenomenon	NN
cord-341050-hnuogpqn	353	119	Viral	viral	JJ
cord-341050-hnuogpqn	353	120	and	and	CC
cord-341050-hnuogpqn	353	121	cellular	cellular	JJ
cord-341050-hnuogpqn	353	122	RNA	RNA	NNP
cord-341050-hnuogpqn	353	123	helicases	helicase	NNS
cord-341050-hnuogpqn	353	124	as	as	IN
cord-341050-hnuogpqn	353	125	antiviral	antiviral	JJ
cord-341050-hnuogpqn	353	126	targets	target	NNS
cord-341050-hnuogpqn	353	127	Halogenated	halogenate	VBN
cord-341050-hnuogpqn	353	128	benzimidazoles	benzimidazole	NNS
cord-341050-hnuogpqn	353	129	and	and	CC
cord-341050-hnuogpqn	353	130	benzotriazoles	benzotriazole	NNS
cord-341050-hnuogpqn	353	131	as	as	IN
cord-341050-hnuogpqn	353	132	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	353	133	of	of	IN
cord-341050-hnuogpqn	353	134	the	the	DT
cord-341050-hnuogpqn	353	135	NTPase/	NTPase/	NNP
cord-341050-hnuogpqn	353	136	helicase	helicase	NN
cord-341050-hnuogpqn	353	137	activities	activity	NNS
cord-341050-hnuogpqn	353	138	of	of	IN
cord-341050-hnuogpqn	353	139	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	353	140	C	C	NNP
cord-341050-hnuogpqn	353	141	and	and	CC
cord-341050-hnuogpqn	353	142	related	relate	VBN
cord-341050-hnuogpqn	353	143	viruses	virus	NNS
cord-341050-hnuogpqn	353	144	Synthesis	synthesis	NN
cord-341050-hnuogpqn	353	145	and	and	CC
cord-341050-hnuogpqn	353	146	evaluation	evaluation	NN
cord-341050-hnuogpqn	353	147	of	of	IN
cord-341050-hnuogpqn	353	148	ATP	ATP	NNP
cord-341050-hnuogpqn	353	149	-	-	HYPH
cord-341050-hnuogpqn	353	150	binding	bind	VBG
cord-341050-hnuogpqn	353	151	site	site	NN
cord-341050-hnuogpqn	353	152	directed	direct	VBD
cord-341050-hnuogpqn	353	153	potential	potential	JJ
cord-341050-hnuogpqn	353	154	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	353	155	of	of	IN
cord-341050-hnuogpqn	353	156	nucleoside	nucleoside	NN
cord-341050-hnuogpqn	353	157	triphosphatases	triphosphatase	NNS
cord-341050-hnuogpqn	353	158	/	/	SYM
cord-341050-hnuogpqn	353	159	helicases	helicase	NNS
cord-341050-hnuogpqn	353	160	and	and	CC
cord-341050-hnuogpqn	353	161	polymerases	polymerase	NNS
cord-341050-hnuogpqn	353	162	of	of	IN
cord-341050-hnuogpqn	353	163	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	353	164	C	C	NNP
cord-341050-hnuogpqn	353	165	and	and	CC
cord-341050-hnuogpqn	353	166	other	other	JJ
cord-341050-hnuogpqn	353	167	selected	select	VBN
cord-341050-hnuogpqn	353	168	Flaviviridae	Flaviviridae	NNP
cord-341050-hnuogpqn	353	169	viruses	virus	NNS
cord-341050-hnuogpqn	354	1	An	an	DT
cord-341050-hnuogpqn	354	2	analogue	analogue	NN
cord-341050-hnuogpqn	354	3	of	of	IN
cord-341050-hnuogpqn	354	4	AICAR	AICAR	NNP
cord-341050-hnuogpqn	354	5	with	with	IN
cord-341050-hnuogpqn	354	6	dual	dual	JJ
cord-341050-hnuogpqn	354	7	inhibitory	inhibitory	JJ
cord-341050-hnuogpqn	354	8	activity	activity	NN
cord-341050-hnuogpqn	354	9	against	against	IN
cord-341050-hnuogpqn	354	10	WNV	WNV	NNP
cord-341050-hnuogpqn	354	11	and	and	CC
cord-341050-hnuogpqn	354	12	HCV	HCV	NNP
cord-341050-hnuogpqn	354	13	NTPase	NTPase	NNP
cord-341050-hnuogpqn	354	14	/	/	SYM
cord-341050-hnuogpqn	354	15	helicase	helicase	NN
cord-341050-hnuogpqn	354	16	:	:	:
cord-341050-hnuogpqn	354	17	synthesis	synthesis	NN
cord-341050-hnuogpqn	354	18	and	and	CC
cord-341050-hnuogpqn	354	19	in	in	IN
cord-341050-hnuogpqn	354	20	vitro	vitro	FW
cord-341050-hnuogpqn	354	21	screening	screening	NN
cord-341050-hnuogpqn	354	22	of	of	IN
cord-341050-hnuogpqn	354	23	4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta	4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta	CD
cord-341050-hnuogpqn	354	24	-	-	HYPH
cord-341050-hnuogpqn	354	25	D	D	NNP
cord-341050-hnuogpqn	354	26	-	-	HYPH
cord-341050-hnuogpqn	354	27	ribo	ribo	JJ
cord-341050-hnuogpqn	354	28	furanoside	furanoside	NN
cord-341050-hnuogpqn	354	29	Ring	ring	NN
cord-341050-hnuogpqn	354	30	-	-	HYPH
cord-341050-hnuogpqn	354	31	expanded	expand	VBN
cord-341050-hnuogpqn	354	32	(	(	-LRB-
cord-341050-hnuogpqn	354	33	"	"	``
cord-341050-hnuogpqn	354	34	fat	fat	JJ
cord-341050-hnuogpqn	354	35	"	"	''
cord-341050-hnuogpqn	354	36	)	)	-RRB-
cord-341050-hnuogpqn	355	1	nucleoside	nucleoside	JJ
cord-341050-hnuogpqn	355	2	and	and	CC
cord-341050-hnuogpqn	355	3	nucleotide	nucleotide	JJ
cord-341050-hnuogpqn	355	4	analogues	analogue	NNS
cord-341050-hnuogpqn	355	5	exhibit	exhibit	VBP
cord-341050-hnuogpqn	355	6	potent	potent	JJ
cord-341050-hnuogpqn	355	7	in	in	IN
cord-341050-hnuogpqn	355	8	vitro	vitro	FW
cord-341050-hnuogpqn	355	9	activity	activity	NN
cord-341050-hnuogpqn	355	10	against	against	IN
cord-341050-hnuogpqn	355	11	fl	fl	NNP
cord-341050-hnuogpqn	355	12	aviviridae	aviviridae	NNP
cord-341050-hnuogpqn	355	13	NTPases	NTPases	NNP
cord-341050-hnuogpqn	355	14	/	/	SYM
cord-341050-hnuogpqn	355	15	helicases	helicase	NNS
cord-341050-hnuogpqn	355	16	,	,	,
cord-341050-hnuogpqn	355	17	including	include	VBG
cord-341050-hnuogpqn	355	18	those	those	DT
cord-341050-hnuogpqn	355	19	of	of	IN
cord-341050-hnuogpqn	355	20	the	the	DT
cord-341050-hnuogpqn	355	21	West	West	NNP
cord-341050-hnuogpqn	355	22	Nile	Nile	NNP
cord-341050-hnuogpqn	355	23	virus	virus	NN
cord-341050-hnuogpqn	355	24	,	,	,
cord-341050-hnuogpqn	355	25	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	355	26	C	C	NNP
cord-341050-hnuogpqn	355	27	virus	virus	NN
cord-341050-hnuogpqn	355	28	,	,	,
cord-341050-hnuogpqn	355	29	and	and	CC
cord-341050-hnuogpqn	355	30	Japanese	japanese	JJ
cord-341050-hnuogpqn	355	31	encephalitis	encephalitis	RB
cord-341050-hnuogpqn	355	32	virus	virus	NN
cord-341050-hnuogpqn	355	33	Potent	potent	JJ
cord-341050-hnuogpqn	355	34	inhibition	inhibition	NN
cord-341050-hnuogpqn	355	35	of	of	IN
cord-341050-hnuogpqn	355	36	NTPase	NTPase	NNP
cord-341050-hnuogpqn	355	37	/	/	SYM
cord-341050-hnuogpqn	355	38	helicase	helicase	NN
cord-341050-hnuogpqn	355	39	of	of	IN
cord-341050-hnuogpqn	355	40	the	the	DT
cord-341050-hnuogpqn	355	41	West	West	NNP
cord-341050-hnuogpqn	355	42	Nile	Nile	NNP
cord-341050-hnuogpqn	355	43	Virus	Virus	NNP
cord-341050-hnuogpqn	355	44	by	by	IN
cord-341050-hnuogpqn	355	45	ring	ring	NN
cord-341050-hnuogpqn	355	46	-	-	HYPH
cord-341050-hnuogpqn	355	47	expanded	expand	VBN
cord-341050-hnuogpqn	355	48	(	(	-LRB-
cord-341050-hnuogpqn	355	49	"	"	``
cord-341050-hnuogpqn	355	50	fat	fat	JJ
cord-341050-hnuogpqn	355	51	"	"	''
cord-341050-hnuogpqn	355	52	)	)	-RRB-
cord-341050-hnuogpqn	356	1	nucleoside	nucleoside	JJ
cord-341050-hnuogpqn	356	2	analogues	analogues	NNP
cord-341050-hnuogpqn	356	3	Characterization	Characterization	NNP
cord-341050-hnuogpqn	356	4	of	of	IN
cord-341050-hnuogpqn	356	5	imidazo[4,5-d]pyridazine	imidazo[4,5-d]pyridazine	NNP
cord-341050-hnuogpqn	356	6	nucleosides	nucleoside	VBZ
cord-341050-hnuogpqn	356	7	as	as	IN
cord-341050-hnuogpqn	356	8	modulators	modulator	NNS
cord-341050-hnuogpqn	356	9	of	of	IN
cord-341050-hnuogpqn	356	10	unwinding	unwind	VBG
cord-341050-hnuogpqn	356	11	reaction	reaction	NN
cord-341050-hnuogpqn	356	12	mediated	mediate	VBN
cord-341050-hnuogpqn	356	13	by	by	IN
cord-341050-hnuogpqn	356	14	West	West	NNP
cord-341050-hnuogpqn	356	15	Nile	Nile	NNP
cord-341050-hnuogpqn	356	16	virus	virus	NN
cord-341050-hnuogpqn	357	1	nucleoside	nucleoside	RB
cord-341050-hnuogpqn	357	2	triphosphatase	triphosphatase	NNP
cord-341050-hnuogpqn	357	3	/	/	SYM
cord-341050-hnuogpqn	357	4	helicase	helicase	NN
cord-341050-hnuogpqn	357	5	:	:	:
cord-341050-hnuogpqn	357	6	evidence	evidence	NN
cord-341050-hnuogpqn	357	7	for	for	IN
cord-341050-hnuogpqn	357	8	activity	activity	NN
cord-341050-hnuogpqn	357	9	on	on	IN
cord-341050-hnuogpqn	357	10	the	the	DT
cord-341050-hnuogpqn	357	11	level	level	NN
cord-341050-hnuogpqn	357	12	of	of	IN
cord-341050-hnuogpqn	357	13	substrate	substrate	NN
cord-341050-hnuogpqn	357	14	and/	and/	CD
cord-341050-hnuogpqn	357	15	or	or	CC
cord-341050-hnuogpqn	357	16	enzyme	enzyme	NN
cord-341050-hnuogpqn	358	1	Ivermectin	Ivermectin	NNP
cord-341050-hnuogpqn	358	2	is	be	VBZ
cord-341050-hnuogpqn	358	3	a	a	DT
cord-341050-hnuogpqn	358	4	potent	potent	JJ
cord-341050-hnuogpqn	358	5	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	358	6	of	of	IN
cord-341050-hnuogpqn	358	7	fl	fl	NNP
cord-341050-hnuogpqn	358	8	avivirus	avivirus	NNP
cord-341050-hnuogpqn	358	9	replication	replication	NN
cord-341050-hnuogpqn	358	10	specifi	specifi	NNP
cord-341050-hnuogpqn	358	11	cally	cally	RB
cord-341050-hnuogpqn	358	12	targeting	target	VBG
cord-341050-hnuogpqn	358	13	NS3	ns3	CC
cord-341050-hnuogpqn	358	14	helicase	helicase	NN
cord-341050-hnuogpqn	358	15	activity	activity	NN
cord-341050-hnuogpqn	358	16	:	:	:
cord-341050-hnuogpqn	358	17	new	new	JJ
cord-341050-hnuogpqn	358	18	prospects	prospect	NNS
cord-341050-hnuogpqn	358	19	for	for	IN
cord-341050-hnuogpqn	358	20	an	an	DT
cord-341050-hnuogpqn	358	21	old	old	JJ
cord-341050-hnuogpqn	358	22	drug	drug	NN
cord-341050-hnuogpqn	358	23	New	new	JJ
cord-341050-hnuogpqn	358	24	insights	insight	NNS
cord-341050-hnuogpqn	358	25	into	into	IN
cord-341050-hnuogpqn	358	26	fl	fl	NNP
cord-341050-hnuogpqn	358	27	avivirus	avivirus	JJ
cord-341050-hnuogpqn	358	28	nonstructural	nonstructural	JJ
cord-341050-hnuogpqn	358	29	protein	protein	NN
cord-341050-hnuogpqn	358	30	5	5	CD
cord-341050-hnuogpqn	358	31	Comparative	Comparative	NNP
cord-341050-hnuogpqn	358	32	mechanistic	mechanistic	JJ
cord-341050-hnuogpqn	358	33	studies	study	NNS
cord-341050-hnuogpqn	358	34	of	of	IN
cord-341050-hnuogpqn	358	35	de	de	NNP
cord-341050-hnuogpqn	358	36	novo	novo	NNP
cord-341050-hnuogpqn	358	37	RNA	RNA	NNP
cord-341050-hnuogpqn	358	38	synthesis	synthesis	NN
cord-341050-hnuogpqn	358	39	by	by	IN
cord-341050-hnuogpqn	358	40	fl	fl	NNP
cord-341050-hnuogpqn	358	41	avivirus	avivirus	NNP
cord-341050-hnuogpqn	358	42	RNA	RNA	NNP
cord-341050-hnuogpqn	358	43	-	-	HYPH
cord-341050-hnuogpqn	358	44	dependent	dependent	JJ
cord-341050-hnuogpqn	358	45	RNA	RNA	NNP
cord-341050-hnuogpqn	358	46	polymerases	polymerase	NNS
cord-341050-hnuogpqn	359	1	The	the	DT
cord-341050-hnuogpqn	359	2	fl	fl	NNP
cord-341050-hnuogpqn	359	3	avivirus	avivirus	NN
cord-341050-hnuogpqn	359	4	polymerase	polymerase	NN
cord-341050-hnuogpqn	359	5	as	as	IN
cord-341050-hnuogpqn	359	6	a	a	DT
cord-341050-hnuogpqn	359	7	target	target	NN
cord-341050-hnuogpqn	359	8	for	for	IN
cord-341050-hnuogpqn	359	9	drug	drug	NN
cord-341050-hnuogpqn	359	10	discovery	discovery	NN
cord-341050-hnuogpqn	359	11	Advances	advance	VBZ
cord-341050-hnuogpqn	359	12	in	in	IN
cord-341050-hnuogpqn	359	13	the	the	DT
cord-341050-hnuogpqn	359	14	development	development	NN
cord-341050-hnuogpqn	359	15	of	of	IN
cord-341050-hnuogpqn	359	16	new	new	JJ
cord-341050-hnuogpqn	359	17	therapeutic	therapeutic	JJ
cord-341050-hnuogpqn	359	18	agents	agent	NNS
cord-341050-hnuogpqn	359	19	targeting	target	VBG
cord-341050-hnuogpqn	359	20	the	the	DT
cord-341050-hnuogpqn	359	21	NS3	ns3	RB
cord-341050-hnuogpqn	359	22	-	-	HYPH
cord-341050-hnuogpqn	359	23	4A	4a	CD
cord-341050-hnuogpqn	359	24	serine	serine	NN
cord-341050-hnuogpqn	359	25	protease	protease	NN
cord-341050-hnuogpqn	359	26	or	or	CC
cord-341050-hnuogpqn	359	27	the	the	DT
cord-341050-hnuogpqn	359	28	NS5B	NS5B	NNP
cord-341050-hnuogpqn	359	29	RNA	RNA	NNP
cord-341050-hnuogpqn	359	30	-	-	HYPH
cord-341050-hnuogpqn	359	31	dependent	dependent	JJ
cord-341050-hnuogpqn	359	32	RNA	RNA	NNP
cord-341050-hnuogpqn	359	33	polymerase	polymerase	NN
cord-341050-hnuogpqn	359	34	of	of	IN
cord-341050-hnuogpqn	359	35	the	the	DT
cord-341050-hnuogpqn	359	36	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	359	37	C	C	NNP
cord-341050-hnuogpqn	359	38	virus	virus	NN
cord-341050-hnuogpqn	360	1	Recent	recent	JJ
cord-341050-hnuogpqn	360	2	highlights	highlight	NNS
cord-341050-hnuogpqn	360	3	in	in	IN
cord-341050-hnuogpqn	360	4	the	the	DT
cord-341050-hnuogpqn	360	5	development	development	NN
cord-341050-hnuogpqn	360	6	of	of	IN
cord-341050-hnuogpqn	360	7	new	new	JJ
cord-341050-hnuogpqn	360	8	antiviral	antiviral	JJ
cord-341050-hnuogpqn	360	9	drugs	drug	NNS
cord-341050-hnuogpqn	360	10	Identifi	Identifi	NNP
cord-341050-hnuogpqn	360	11	cation	cation	NN
cord-341050-hnuogpqn	360	12	of	of	IN
cord-341050-hnuogpqn	360	13	a	a	DT
cord-341050-hnuogpqn	360	14	small	small	JJ
cord-341050-hnuogpqn	360	15	molecule	molecule	NN
cord-341050-hnuogpqn	360	16	that	that	WDT
cord-341050-hnuogpqn	360	17	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	360	18	herpes	herpes	NN
cord-341050-hnuogpqn	360	19	simplex	simplex	NN
cord-341050-hnuogpqn	360	20	virus	virus	NN
cord-341050-hnuogpqn	360	21	DNA	dna	NN
cord-341050-hnuogpqn	360	22	polymerase	polymerase	NN
cord-341050-hnuogpqn	360	23	subunit	subunit	NN
cord-341050-hnuogpqn	360	24	interactions	interaction	NNS
cord-341050-hnuogpqn	360	25	and	and	CC
cord-341050-hnuogpqn	360	26	viral	viral	JJ
cord-341050-hnuogpqn	360	27	replication	replication	NN
cord-341050-hnuogpqn	361	1	A	a	DT
cord-341050-hnuogpqn	361	2	homogeneous	homogeneous	JJ
cord-341050-hnuogpqn	361	3	,	,	,
cord-341050-hnuogpqn	361	4	solid	solid	JJ
cord-341050-hnuogpqn	361	5	-	-	HYPH
cord-341050-hnuogpqn	361	6	phase	phase	NN
cord-341050-hnuogpqn	361	7	assay	assay	NN
cord-341050-hnuogpqn	361	8	for	for	IN
cord-341050-hnuogpqn	361	9	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	361	10	C	C	NNP
cord-341050-hnuogpqn	361	11	virus	virus	NN
cord-341050-hnuogpqn	361	12	RNA	rna	NN
cord-341050-hnuogpqn	361	13	-	-	HYPH
cord-341050-hnuogpqn	361	14	dependent	dependent	JJ
cord-341050-hnuogpqn	361	15	RNA	RNA	NNP
cord-341050-hnuogpqn	361	16	polymerase	polymerase	NN
cord-341050-hnuogpqn	361	17	A	a	DT
cord-341050-hnuogpqn	361	18	cell	cell	NN
cord-341050-hnuogpqn	361	19	-	-	HYPH
cord-341050-hnuogpqn	361	20	based	base	VBN
cord-341050-hnuogpqn	361	21	reporter	reporter	NN
cord-341050-hnuogpqn	361	22	assay	assay	NN
cord-341050-hnuogpqn	361	23	for	for	IN
cord-341050-hnuogpqn	361	24	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	361	25	screening	screening	NN
cord-341050-hnuogpqn	361	26	of	of	IN
cord-341050-hnuogpqn	361	27	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	361	28	C	C	NNP
cord-341050-hnuogpqn	361	29	virus	virus	NN
cord-341050-hnuogpqn	361	30	RNA	RNA	NNP
cord-341050-hnuogpqn	361	31	-	-	HYPH
cord-341050-hnuogpqn	361	32	dependent	dependent	JJ
cord-341050-hnuogpqn	361	33	RNA	RNA	NNP
cord-341050-hnuogpqn	361	34	polymerase	polymerase	NN
cord-341050-hnuogpqn	362	1	A	a	DT
cord-341050-hnuogpqn	362	2	continuous	continuous	JJ
cord-341050-hnuogpqn	362	3	nonradioactive	nonradioactive	JJ
cord-341050-hnuogpqn	362	4	assay	assay	NN
cord-341050-hnuogpqn	362	5	for	for	IN
cord-341050-hnuogpqn	362	6	RNA	RNA	NNP
cord-341050-hnuogpqn	362	7	-	-	HYPH
cord-341050-hnuogpqn	362	8	dependent	dependent	JJ
cord-341050-hnuogpqn	362	9	RNA	RNA	NNP
cord-341050-hnuogpqn	362	10	polymerase	polymerase	NN
cord-341050-hnuogpqn	362	11	activity	activity	NN
cord-341050-hnuogpqn	362	12	Synergistic	synergistic	JJ
cord-341050-hnuogpqn	362	13	combinations	combination	NNS
cord-341050-hnuogpqn	362	14	of	of	IN
cord-341050-hnuogpqn	362	15	favipiravir	favipiravir	NNS
cord-341050-hnuogpqn	362	16	and	and	CC
cord-341050-hnuogpqn	362	17	oseltamivir	oseltamivir	NN
cord-341050-hnuogpqn	362	18	against	against	IN
cord-341050-hnuogpqn	362	19	wild	wild	JJ
cord-341050-hnuogpqn	362	20	-	-	HYPH
cord-341050-hnuogpqn	362	21	type	type	NN
cord-341050-hnuogpqn	362	22	pandemic	pandemic	NN
cord-341050-hnuogpqn	362	23	and	and	CC
cord-341050-hnuogpqn	362	24	oseltamivir	oseltamivir	NN
cord-341050-hnuogpqn	362	25	-	-	HYPH
cord-341050-hnuogpqn	362	26	resistant	resistant	JJ
cord-341050-hnuogpqn	362	27	infl	infl	NN
cord-341050-hnuogpqn	362	28	uenza	uenza	NNP
cord-341050-hnuogpqn	362	29	A	a	DT
cord-341050-hnuogpqn	362	30	virus	virus	NN
cord-341050-hnuogpqn	362	31	infections	infection	NNS
cord-341050-hnuogpqn	362	32	in	in	IN
cord-341050-hnuogpqn	362	33	mice	mouse	NNS
cord-341050-hnuogpqn	363	1	In	in	IN
cord-341050-hnuogpqn	363	2	vitro	vitro	FW
cord-341050-hnuogpqn	363	3	activity	activity	NN
cord-341050-hnuogpqn	363	4	of	of	IN
cord-341050-hnuogpqn	363	5	favipiravir	favipiravir	NNS
cord-341050-hnuogpqn	363	6	and	and	CC
cord-341050-hnuogpqn	363	7	neuraminidase	neuraminidase	NN
cord-341050-hnuogpqn	363	8	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	363	9	combinations	combination	NNS
cord-341050-hnuogpqn	363	10	against	against	IN
cord-341050-hnuogpqn	363	11	oseltamivir	oseltamivir	NN
cord-341050-hnuogpqn	363	12	-	-	HYPH
cord-341050-hnuogpqn	363	13	sensitive	sensitive	JJ
cord-341050-hnuogpqn	363	14	and	and	CC
cord-341050-hnuogpqn	363	15	oseltamivir	oseltamivir	JJ
cord-341050-hnuogpqn	363	16	-	-	HYPH
cord-341050-hnuogpqn	363	17	resistant	resistant	JJ
cord-341050-hnuogpqn	363	18	pandemic	pandemic	NN
cord-341050-hnuogpqn	363	19	infl	infl	NN
cord-341050-hnuogpqn	364	1	uenza	uenza	NNP
cord-341050-hnuogpqn	364	2	A	A	NNP
cord-341050-hnuogpqn	364	3	(	(	-LRB-
cord-341050-hnuogpqn	364	4	H1N1	H1N1	NNP
cord-341050-hnuogpqn	364	5	)	)	-RRB-
cord-341050-hnuogpqn	364	6	virus	virus	NN
cord-341050-hnuogpqn	364	7	Favipiravir	Favipiravir	NNP
cord-341050-hnuogpqn	364	8	(	(	-LRB-
cord-341050-hnuogpqn	364	9	T-705	t-705	NN
cord-341050-hnuogpqn	364	10	)	)	-RRB-
cord-341050-hnuogpqn	364	11	,	,	,
cord-341050-hnuogpqn	364	12	a	a	DT
cord-341050-hnuogpqn	364	13	novel	novel	JJ
cord-341050-hnuogpqn	364	14	viral	viral	JJ
cord-341050-hnuogpqn	364	15	RNA	rna	NN
cord-341050-hnuogpqn	364	16	polymerase	polymerase	NN
cord-341050-hnuogpqn	364	17	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	364	18	Broadspectrum	Broadspectrum	NNP
cord-341050-hnuogpqn	364	19	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	364	20	of	of	IN
cord-341050-hnuogpqn	364	21	viruses	virus	NNS
cord-341050-hnuogpqn	364	22	in	in	IN
cord-341050-hnuogpqn	364	23	the	the	DT
cord-341050-hnuogpqn	364	24	Flaviviridae	Flaviviridae	NNP
cord-341050-hnuogpqn	364	25	family	family	NN
cord-341050-hnuogpqn	365	1	A	a	DT
cord-341050-hnuogpqn	365	2	7-deaza	7-deaza	CD
cord-341050-hnuogpqn	365	3	-	-	HYPH
cord-341050-hnuogpqn	365	4	adenosine	adenosine	NN
cord-341050-hnuogpqn	365	5	analog	analog	NN
cord-341050-hnuogpqn	365	6	is	be	VBZ
cord-341050-hnuogpqn	365	7	a	a	DT
cord-341050-hnuogpqn	365	8	potent	potent	JJ
cord-341050-hnuogpqn	365	9	and	and	CC
cord-341050-hnuogpqn	365	10	selective	selective	JJ
cord-341050-hnuogpqn	365	11	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	365	12	of	of	IN
cord-341050-hnuogpqn	365	13	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	365	14	C	C	NNP
cord-341050-hnuogpqn	365	15	virus	virus	NN
cord-341050-hnuogpqn	365	16	replication	replication	NN
cord-341050-hnuogpqn	365	17	with	with	IN
cord-341050-hnuogpqn	365	18	excellent	excellent	JJ
cord-341050-hnuogpqn	365	19	pharmacokinetic	pharmacokinetic	JJ
cord-341050-hnuogpqn	365	20	properties	property	NNS
cord-341050-hnuogpqn	366	1	A	a	DT
cord-341050-hnuogpqn	366	2	dengue	dengue	NN
cord-341050-hnuogpqn	366	3	fever	fever	NN
cord-341050-hnuogpqn	366	4	viremia	viremia	NN
cord-341050-hnuogpqn	366	5	model	model	NN
cord-341050-hnuogpqn	366	6	in	in	IN
cord-341050-hnuogpqn	366	7	mice	mouse	NNS
cord-341050-hnuogpqn	366	8	shows	show	VBZ
cord-341050-hnuogpqn	366	9	reduction	reduction	NN
cord-341050-hnuogpqn	366	10	in	in	IN
cord-341050-hnuogpqn	366	11	viral	viral	JJ
cord-341050-hnuogpqn	366	12	replication	replication	NN
cord-341050-hnuogpqn	366	13	and	and	CC
cord-341050-hnuogpqn	366	14	suppression	suppression	NN
cord-341050-hnuogpqn	366	15	of	of	IN
cord-341050-hnuogpqn	366	16	the	the	DT
cord-341050-hnuogpqn	366	17	infl	infl	NNP
cord-341050-hnuogpqn	366	18	ammatory	ammatory	NNP
cord-341050-hnuogpqn	366	19	response	response	NN
cord-341050-hnuogpqn	366	20	after	after	IN
cord-341050-hnuogpqn	366	21	treatment	treatment	NN
cord-341050-hnuogpqn	366	22	with	with	IN
cord-341050-hnuogpqn	366	23	antiviral	antiviral	JJ
cord-341050-hnuogpqn	366	24	drugs	drug	NNS
cord-341050-hnuogpqn	366	25	Crystal	Crystal	NNP
cord-341050-hnuogpqn	366	26	structure	structure	NN
cord-341050-hnuogpqn	366	27	of	of	IN
cord-341050-hnuogpqn	366	28	the	the	DT
cord-341050-hnuogpqn	366	29	dengue	dengue	NN
cord-341050-hnuogpqn	366	30	virus	virus	NN
cord-341050-hnuogpqn	366	31	RNAdependent	RNAdependent	NNP
cord-341050-hnuogpqn	366	32	RNA	RNA	NNP
cord-341050-hnuogpqn	367	1	polymerase	polymerase	NN
cord-341050-hnuogpqn	367	2	catalytic	catalytic	JJ
cord-341050-hnuogpqn	367	3	domain	domain	NN
cord-341050-hnuogpqn	367	4	at	at	IN
cord-341050-hnuogpqn	367	5	1.85-angstrom	1.85-angstrom	CD
cord-341050-hnuogpqn	367	6	resolution	resolution	NN
cord-341050-hnuogpqn	367	7	Inhibition	inhibition	NN
cord-341050-hnuogpqn	367	8	of	of	IN
cord-341050-hnuogpqn	367	9	dengue	dengue	NN
cord-341050-hnuogpqn	367	10	virus	virus	NN
cord-341050-hnuogpqn	367	11	polymerase	polymerase	NN
cord-341050-hnuogpqn	367	12	by	by	IN
cord-341050-hnuogpqn	367	13	blocking	block	VBG
cord-341050-hnuogpqn	367	14	of	of	IN
cord-341050-hnuogpqn	367	15	the	the	DT
cord-341050-hnuogpqn	367	16	RNA	RNA	NNP
cord-341050-hnuogpqn	367	17	tunnel	tunnel	NN
cord-341050-hnuogpqn	367	18	Conformational	Conformational	NNP
cord-341050-hnuogpqn	367	19	fl	fl	NNP
cord-341050-hnuogpqn	367	20	exibility	exibility	NN
cord-341050-hnuogpqn	367	21	of	of	IN
cord-341050-hnuogpqn	367	22	the	the	DT
cord-341050-hnuogpqn	367	23	dengue	dengue	NN
cord-341050-hnuogpqn	367	24	virus	virus	NN
cord-341050-hnuogpqn	368	1	RNA	RNA	NNP
cord-341050-hnuogpqn	368	2	-	-	HYPH
cord-341050-hnuogpqn	368	3	dependent	dependent	JJ
cord-341050-hnuogpqn	368	4	RNA	RNA	NNP
cord-341050-hnuogpqn	368	5	polymerase	polymerase	NN
cord-341050-hnuogpqn	368	6	revealed	reveal	VBN
cord-341050-hnuogpqn	368	7	by	by	IN
cord-341050-hnuogpqn	368	8	a	a	DT
cord-341050-hnuogpqn	368	9	complex	complex	NN
cord-341050-hnuogpqn	368	10	with	with	IN
cord-341050-hnuogpqn	368	11	an	an	DT
cord-341050-hnuogpqn	368	12	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	368	13	An	an	DT
cord-341050-hnuogpqn	368	14	RNA	RNA	NNP
cord-341050-hnuogpqn	368	15	cap	cap	NN
cord-341050-hnuogpqn	368	16	(	(	-LRB-
cord-341050-hnuogpqn	368	17	nucleoside-2′-O-)-methyltransferase	nucleoside-2′-o-)-methyltransferase	CD
cord-341050-hnuogpqn	368	18	in	in	IN
cord-341050-hnuogpqn	368	19	the	the	DT
cord-341050-hnuogpqn	368	20	fl	fl	NNP
cord-341050-hnuogpqn	368	21	avivirus	avivirus	NNP
cord-341050-hnuogpqn	368	22	RNA	RNA	NNP
cord-341050-hnuogpqn	368	23	polymerase	polymerase	NN
cord-341050-hnuogpqn	368	24	NS5	NS5	NNP
cord-341050-hnuogpqn	368	25	:	:	:
cord-341050-hnuogpqn	368	26	crystal	crystal	NN
cord-341050-hnuogpqn	368	27	structure	structure	NN
cord-341050-hnuogpqn	368	28	and	and	CC
cord-341050-hnuogpqn	368	29	functional	functional	JJ
cord-341050-hnuogpqn	368	30	characterization	characterization	NN
cord-341050-hnuogpqn	368	31	Structure	structure	NN
cord-341050-hnuogpqn	368	32	and	and	CC
cord-341050-hnuogpqn	368	33	function	function	NN
cord-341050-hnuogpqn	368	34	of	of	IN
cord-341050-hnuogpqn	368	35	fl	fl	NNP
cord-341050-hnuogpqn	368	36	avivirus	avivirus	NNP
cord-341050-hnuogpqn	369	1	NS5	ns5	JJ
cord-341050-hnuogpqn	369	2	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	369	3	2′-O	2′-o	CD
cord-341050-hnuogpqn	369	4	methylation	methylation	NN
cord-341050-hnuogpqn	369	5	of	of	IN
cord-341050-hnuogpqn	369	6	the	the	DT
cord-341050-hnuogpqn	369	7	viral	viral	JJ
cord-341050-hnuogpqn	369	8	mRNA	mRNA	NNP
cord-341050-hnuogpqn	369	9	cap	cap	NN
cord-341050-hnuogpqn	369	10	evades	evade	VBZ
cord-341050-hnuogpqn	369	11	host	host	NN
cord-341050-hnuogpqn	369	12	restriction	restriction	NN
cord-341050-hnuogpqn	369	13	by	by	IN
cord-341050-hnuogpqn	369	14	IFIT	IFIT	NNP
cord-341050-hnuogpqn	369	15	family	family	NN
cord-341050-hnuogpqn	369	16	members	member	NNS
cord-341050-hnuogpqn	369	17	2′-O	2′-o	CD
cord-341050-hnuogpqn	369	18	methylation	methylation	NNS
cord-341050-hnuogpqn	369	19	of	of	IN
cord-341050-hnuogpqn	369	20	internal	internal	JJ
cord-341050-hnuogpqn	369	21	adenosine	adenosine	NN
cord-341050-hnuogpqn	369	22	by	by	IN
cord-341050-hnuogpqn	369	23	fl	fl	NNP
cord-341050-hnuogpqn	369	24	avivirus	avivirus	NNP
cord-341050-hnuogpqn	370	1	NS5	ns5	JJ
cord-341050-hnuogpqn	370	2	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	370	3	Structural	structural	JJ
cord-341050-hnuogpqn	370	4	and	and	CC
cord-341050-hnuogpqn	370	5	functional	functional	JJ
cord-341050-hnuogpqn	370	6	analyses	analysis	NNS
cord-341050-hnuogpqn	370	7	of	of	IN
cord-341050-hnuogpqn	370	8	a	a	DT
cord-341050-hnuogpqn	370	9	conserved	conserved	JJ
cord-341050-hnuogpqn	370	10	hydrophobic	hydrophobic	JJ
cord-341050-hnuogpqn	370	11	pocket	pocket	NN
cord-341050-hnuogpqn	370	12	of	of	IN
cord-341050-hnuogpqn	370	13	fl	fl	NNP
cord-341050-hnuogpqn	370	14	avivirus	avivirus	NNP
cord-341050-hnuogpqn	371	1	methyltransferase	methyltransferase	NNP
cord-341050-hnuogpqn	372	1	A	a	DT
cord-341050-hnuogpqn	372	2	structural	structural	JJ
cord-341050-hnuogpqn	372	3	basis	basis	NN
cord-341050-hnuogpqn	372	4	for	for	IN
cord-341050-hnuogpqn	372	5	the	the	DT
cord-341050-hnuogpqn	372	6	inhibition	inhibition	NN
cord-341050-hnuogpqn	372	7	of	of	IN
cord-341050-hnuogpqn	372	8	the	the	DT
cord-341050-hnuogpqn	372	9	NS5	ns5	JJ
cord-341050-hnuogpqn	372	10	dengue	dengue	NN
cord-341050-hnuogpqn	372	11	virus	virus	NN
cord-341050-hnuogpqn	372	12	mRNA	mRNA	NNP
cord-341050-hnuogpqn	372	13	2′-O	2′-o	CD
cord-341050-hnuogpqn	372	14	-	-	HYPH
cord-341050-hnuogpqn	372	15	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	372	16	domain	domain	NN
cord-341050-hnuogpqn	372	17	by	by	IN
cord-341050-hnuogpqn	372	18	ribavirin	ribavirin	NN
cord-341050-hnuogpqn	372	19	5′-triphosphate	5′-triphosphate	CD
cord-341050-hnuogpqn	372	20	Flaviviral	Flaviviral	NNP
cord-341050-hnuogpqn	372	21	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	372	22	/	/	SYM
cord-341050-hnuogpqn	372	23	RNA	RNA	NNP
cord-341050-hnuogpqn	372	24	interaction	interaction	NN
cord-341050-hnuogpqn	372	25	:	:	:
cord-341050-hnuogpqn	372	26	structural	structural	JJ
cord-341050-hnuogpqn	372	27	basis	basis	NN
cord-341050-hnuogpqn	372	28	for	for	IN
cord-341050-hnuogpqn	372	29	enzyme	enzyme	NN
cord-341050-hnuogpqn	372	30	inhibition	inhibition	NN
cord-341050-hnuogpqn	372	31	Biochemical	biochemical	JJ
cord-341050-hnuogpqn	372	32	characterization	characterization	NN
cord-341050-hnuogpqn	372	33	of	of	IN
cord-341050-hnuogpqn	372	34	the	the	DT
cord-341050-hnuogpqn	372	35	(	(	-LRB-
cord-341050-hnuogpqn	372	36	nucleoside-2′O)-methyltransferase	nucleoside-2′o)-methyltransferase	JJ
cord-341050-hnuogpqn	372	37	activity	activity	NN
cord-341050-hnuogpqn	372	38	of	of	IN
cord-341050-hnuogpqn	372	39	dengue	dengue	NN
cord-341050-hnuogpqn	372	40	virus	virus	NN
cord-341050-hnuogpqn	372	41	protein	protein	NN
cord-341050-hnuogpqn	372	42	NS5	ns5	JJ
cord-341050-hnuogpqn	372	43	using	use	VBG
cord-341050-hnuogpqn	372	44	purifi	purifi	NNP
cord-341050-hnuogpqn	372	45	ed	ed	NNP
cord-341050-hnuogpqn	372	46	capped	cap	VBN
cord-341050-hnuogpqn	372	47	RNA	RNA	NNP
cord-341050-hnuogpqn	372	48	oligonucleotides	oligonucleotide	NNS
cord-341050-hnuogpqn	372	49	(	(	-LRB-
cord-341050-hnuogpqn	372	50	7Me	7me	JJ
cord-341050-hnuogpqn	372	51	)	)	-RRB-
cord-341050-hnuogpqn	372	52	GpppAC(n	GpppAC(n	NNP
cord-341050-hnuogpqn	372	53	)	)	-RRB-
cord-341050-hnuogpqn	372	54	and	and	CC
cord-341050-hnuogpqn	372	55	GpppAC(n	GpppAC(n	NNP
cord-341050-hnuogpqn	372	56	)	)	-RRB-
cord-341050-hnuogpqn	373	1	Flavivirus	Flavivirus	NNP
cord-341050-hnuogpqn	373	2	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	373	3	:	:	:
cord-341050-hnuogpqn	373	4	a	a	DT
cord-341050-hnuogpqn	373	5	novel	novel	JJ
cord-341050-hnuogpqn	373	6	antiviral	antiviral	JJ
cord-341050-hnuogpqn	373	7	target	target	NN
cord-341050-hnuogpqn	374	1	The	the	DT
cord-341050-hnuogpqn	374	2	fl	fl	NNP
cord-341050-hnuogpqn	374	3	avivirus	avivirus	NN
cord-341050-hnuogpqn	374	4	NS5	ns5	JJ
cord-341050-hnuogpqn	374	5	protein	protein	NN
cord-341050-hnuogpqn	374	6	is	be	VBZ
cord-341050-hnuogpqn	374	7	a	a	DT
cord-341050-hnuogpqn	374	8	true	true	JJ
cord-341050-hnuogpqn	374	9	RNA	rna	NN
cord-341050-hnuogpqn	374	10	guanylyltransferase	guanylyltransferase	NN
cord-341050-hnuogpqn	374	11	that	that	WDT
cord-341050-hnuogpqn	374	12	catalyzes	catalyze	VBZ
cord-341050-hnuogpqn	374	13	a	a	DT
cord-341050-hnuogpqn	374	14	twostep	twostep	NN
cord-341050-hnuogpqn	374	15	reaction	reaction	NN
cord-341050-hnuogpqn	374	16	to	to	TO
cord-341050-hnuogpqn	374	17	form	form	VB
cord-341050-hnuogpqn	374	18	the	the	DT
cord-341050-hnuogpqn	374	19	RNA	RNA	NNP
cord-341050-hnuogpqn	374	20	cap	cap	NN
cord-341050-hnuogpqn	374	21	structure	structure	NN
cord-341050-hnuogpqn	374	22	Structure	structure	NN
cord-341050-hnuogpqn	374	23	-	-	HYPH
cord-341050-hnuogpqn	374	24	based	base	VBN
cord-341050-hnuogpqn	374	25	and	and	CC
cord-341050-hnuogpqn	374	26	ligand	ligand	NN
cord-341050-hnuogpqn	374	27	-	-	HYPH
cord-341050-hnuogpqn	374	28	based	base	VBN
cord-341050-hnuogpqn	374	29	virtual	virtual	JJ
cord-341050-hnuogpqn	374	30	screening	screening	NN
cord-341050-hnuogpqn	374	31	of	of	IN
cord-341050-hnuogpqn	374	32	novel	novel	JJ
cord-341050-hnuogpqn	374	33	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	374	34	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	374	35	of	of	IN
cord-341050-hnuogpqn	374	36	the	the	DT
cord-341050-hnuogpqn	374	37	dengue	dengue	NN
cord-341050-hnuogpqn	374	38	virus	virus	NN
cord-341050-hnuogpqn	374	39	Small	small	JJ
cord-341050-hnuogpqn	374	40	molecule	molecule	NN
cord-341050-hnuogpqn	374	41	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	374	42	that	that	WDT
cord-341050-hnuogpqn	374	43	selectively	selectively	RB
cord-341050-hnuogpqn	374	44	block	block	VBP
cord-341050-hnuogpqn	374	45	dengue	dengue	NN
cord-341050-hnuogpqn	374	46	virus	virus	NN
cord-341050-hnuogpqn	375	1	methyltransferase	methyltransferase	NNP
cord-341050-hnuogpqn	375	2	Selective	selective	JJ
cord-341050-hnuogpqn	375	3	inhibition	inhibition	NN
cord-341050-hnuogpqn	375	4	of	of	IN
cord-341050-hnuogpqn	375	5	the	the	DT
cord-341050-hnuogpqn	375	6	West	West	NNP
cord-341050-hnuogpqn	375	7	Nile	Nile	NNP
cord-341050-hnuogpqn	375	8	virus	virus	NN
cord-341050-hnuogpqn	375	9	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	375	10	by	by	IN
cord-341050-hnuogpqn	375	11	nucleoside	nucleoside	JJ
cord-341050-hnuogpqn	375	12	analogs	analog	NNS
cord-341050-hnuogpqn	376	1	Identifi	Identifi	NNP
cord-341050-hnuogpqn	376	2	cation	cation	NN
cord-341050-hnuogpqn	376	3	of	of	IN
cord-341050-hnuogpqn	376	4	a	a	DT
cord-341050-hnuogpqn	376	5	novel	novel	JJ
cord-341050-hnuogpqn	376	6	antiviral	antiviral	JJ
cord-341050-hnuogpqn	376	7	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	376	8	of	of	IN
cord-341050-hnuogpqn	376	9	the	the	DT
cord-341050-hnuogpqn	376	10	fl	fl	NNP
cord-341050-hnuogpqn	376	11	avivirus	avivirus	NNP
cord-341050-hnuogpqn	376	12	guanylyltransferase	guanylyltransferase	NN
cord-341050-hnuogpqn	376	13	enzyme	enzyme	NN
cord-341050-hnuogpqn	376	14	Virtual	virtual	JJ
cord-341050-hnuogpqn	376	15	screening	screening	NN
cord-341050-hnuogpqn	376	16	and	and	CC
cord-341050-hnuogpqn	376	17	bioassay	bioassay	NN
cord-341050-hnuogpqn	376	18	study	study	NN
cord-341050-hnuogpqn	376	19	of	of	IN
cord-341050-hnuogpqn	376	20	novel	novel	JJ
cord-341050-hnuogpqn	376	21	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	376	22	for	for	IN
cord-341050-hnuogpqn	376	23	dengue	dengue	NN
cord-341050-hnuogpqn	376	24	virus	virus	NN
cord-341050-hnuogpqn	376	25	mRNA	mRNA	NNP
cord-341050-hnuogpqn	376	26	cap	cap	NNP
cord-341050-hnuogpqn	376	27	Novel	Novel	NNP
cord-341050-hnuogpqn	376	28	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	376	29	of	of	IN
cord-341050-hnuogpqn	377	1	dengue	dengue	NN
cord-341050-hnuogpqn	377	2	virus	virus	NN
cord-341050-hnuogpqn	377	3	methyltransferase	methyltransferase	NN
cord-341050-hnuogpqn	377	4	:	:	:
cord-341050-hnuogpqn	377	5	discovery	discovery	NN
cord-341050-hnuogpqn	377	6	by	by	IN
cord-341050-hnuogpqn	377	7	in	in	IN
cord-341050-hnuogpqn	377	8	vitro	vitro	FW
cord-341050-hnuogpqn	377	9	-	-	HYPH
cord-341050-hnuogpqn	377	10	driven	drive	VBN
cord-341050-hnuogpqn	377	11	virtual	virtual	JJ
cord-341050-hnuogpqn	377	12	screening	screening	NN
cord-341050-hnuogpqn	377	13	on	on	IN
cord-341050-hnuogpqn	377	14	a	a	DT
cord-341050-hnuogpqn	377	15	desktop	desktop	NN
cord-341050-hnuogpqn	377	16	computer	computer	NN
cord-341050-hnuogpqn	377	17	grid	grid	NN
cord-341050-hnuogpqn	377	18	5′-Silylated	5′-silylated	CD
cord-341050-hnuogpqn	377	19	3′-1,2,3-triazolyl	3′-1,2,3-triazolyl	CD
cord-341050-hnuogpqn	377	20	thymidine	thymidine	JJ
cord-341050-hnuogpqn	377	21	analogues	analogue	NNS
cord-341050-hnuogpqn	377	22	as	as	IN
cord-341050-hnuogpqn	377	23	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	377	24	of	of	IN
cord-341050-hnuogpqn	377	25	West	West	NNP
cord-341050-hnuogpqn	377	26	Nile	Nile	NNP
cord-341050-hnuogpqn	377	27	virus	virus	NN
cord-341050-hnuogpqn	377	28	and	and	CC
cord-341050-hnuogpqn	377	29	dengue	dengue	NN
cord-341050-hnuogpqn	377	30	virus	virus	NN
cord-341050-hnuogpqn	377	31	Phage	Phage	NNP
cord-341050-hnuogpqn	377	32	display	display	NN
cord-341050-hnuogpqn	377	33	of	of	IN
cord-341050-hnuogpqn	377	34	combinatorial	combinatorial	JJ
cord-341050-hnuogpqn	377	35	peptide	peptide	NN
cord-341050-hnuogpqn	377	36	libraries	library	NNS
cord-341050-hnuogpqn	377	37	:	:	:
cord-341050-hnuogpqn	377	38	application	application	NN
cord-341050-hnuogpqn	377	39	to	to	IN
cord-341050-hnuogpqn	377	40	antiviral	antiviral	JJ
cord-341050-hnuogpqn	377	41	research	research	NN
cord-341050-hnuogpqn	377	42	Design	design	NN
cord-341050-hnuogpqn	377	43	and	and	CC
cord-341050-hnuogpqn	377	44	structure	structure	NN
cord-341050-hnuogpqn	377	45	of	of	IN
cord-341050-hnuogpqn	377	46	peptide	peptide	JJ
cord-341050-hnuogpqn	377	47	and	and	CC
cord-341050-hnuogpqn	377	48	peptidomimetic	peptidomimetic	JJ
cord-341050-hnuogpqn	377	49	antagonists	antagonist	NNS
cord-341050-hnuogpqn	377	50	of	of	IN
cord-341050-hnuogpqn	377	51	protein	protein	NN
cord-341050-hnuogpqn	377	52	-	-	HYPH
cord-341050-hnuogpqn	377	53	protein	protein	NN
cord-341050-hnuogpqn	377	54	interaction	interaction	NN
cord-341050-hnuogpqn	377	55	HIV-1	HIV-1	NNP
cord-341050-hnuogpqn	377	56	gp41	gp41	NNP
cord-341050-hnuogpqn	377	57	as	as	IN
cord-341050-hnuogpqn	377	58	a	a	DT
cord-341050-hnuogpqn	377	59	target	target	NN
cord-341050-hnuogpqn	377	60	for	for	IN
cord-341050-hnuogpqn	377	61	viral	viral	JJ
cord-341050-hnuogpqn	377	62	entry	entry	NN
cord-341050-hnuogpqn	377	63	inhibition	inhibition	NN
cord-341050-hnuogpqn	377	64	Antiviral	antiviral	JJ
cord-341050-hnuogpqn	377	65	peptides	peptide	NNS
cord-341050-hnuogpqn	377	66	targeting	target	VBG
cord-341050-hnuogpqn	377	67	the	the	DT
cord-341050-hnuogpqn	377	68	West	West	NNP
cord-341050-hnuogpqn	377	69	Nile	Nile	NNP
cord-341050-hnuogpqn	377	70	virus	virus	NN
cord-341050-hnuogpqn	377	71	envelope	envelope	NN
cord-341050-hnuogpqn	377	72	protein	protein	NN
cord-341050-hnuogpqn	377	73	Peptide	Peptide	NNP
cord-341050-hnuogpqn	377	74	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	377	75	of	of	IN
cord-341050-hnuogpqn	377	76	dengue	dengue	NN
cord-341050-hnuogpqn	377	77	virus	virus	NN
cord-341050-hnuogpqn	377	78	and	and	CC
cord-341050-hnuogpqn	377	79	West	West	NNP
cord-341050-hnuogpqn	377	80	Nile	Nile	NNP
cord-341050-hnuogpqn	377	81	virus	virus	NN
cord-341050-hnuogpqn	377	82	infectivity	infectivity	NN
cord-341050-hnuogpqn	377	83	Novel	Novel	NNP
cord-341050-hnuogpqn	377	84	agmatine	agmatine	NNP
cord-341050-hnuogpqn	377	85	dipeptide	dipeptide	NN
cord-341050-hnuogpqn	377	86	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	377	87	against	against	IN
cord-341050-hnuogpqn	377	88	the	the	DT
cord-341050-hnuogpqn	377	89	West	West	NNP
cord-341050-hnuogpqn	377	90	Nile	Nile	NNP
cord-341050-hnuogpqn	377	91	virus	virus	NN
cord-341050-hnuogpqn	377	92	NS2B	NS2B	NNP
cord-341050-hnuogpqn	377	93	/	/	,
cord-341050-hnuogpqn	377	94	NS3	ns3	RB
cord-341050-hnuogpqn	377	95	protease	protease	NN
cord-341050-hnuogpqn	377	96	:	:	:
cord-341050-hnuogpqn	377	97	a	a	DT
cord-341050-hnuogpqn	377	98	P3	P3	NNP
cord-341050-hnuogpqn	377	99	and	and	CC
cord-341050-hnuogpqn	377	100	N	n	CD
cord-341050-hnuogpqn	377	101	-	-	HYPH
cord-341050-hnuogpqn	377	102	cap	cap	NN
cord-341050-hnuogpqn	377	103	optimization	optimization	NN
cord-341050-hnuogpqn	377	104	study	study	NN
cord-341050-hnuogpqn	377	105	Tripeptide	Tripeptide	NNP
cord-341050-hnuogpqn	377	106	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	377	107	of	of	IN
cord-341050-hnuogpqn	377	108	dengue	dengue	NN
cord-341050-hnuogpqn	377	109	and	and	CC
cord-341050-hnuogpqn	377	110	West	West	NNP
cord-341050-hnuogpqn	377	111	Nile	Nile	NNP
cord-341050-hnuogpqn	377	112	virus	virus	NN
cord-341050-hnuogpqn	377	113	NS2B	NS2B	NNP
cord-341050-hnuogpqn	377	114	-	-	:
cord-341050-hnuogpqn	377	115	NS3	ns3	RB
cord-341050-hnuogpqn	378	1	protease	protease	NNP
cord-341050-hnuogpqn	378	2	Peptide	Peptide	NNP
cord-341050-hnuogpqn	378	3	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	378	4	of	of	IN
cord-341050-hnuogpqn	379	1	West	West	NNP
cord-341050-hnuogpqn	379	2	Nile	Nile	NNP
cord-341050-hnuogpqn	379	3	NS3	ns3	RB
cord-341050-hnuogpqn	379	4	protease	protease	NN
cord-341050-hnuogpqn	379	5	:	:	:
cord-341050-hnuogpqn	379	6	SAR	SAR	NNP
cord-341050-hnuogpqn	379	7	study	study	NN
cord-341050-hnuogpqn	379	8	of	of	IN
cord-341050-hnuogpqn	379	9	tetrapeptide	tetrapeptide	NNP
cord-341050-hnuogpqn	380	1	aldehyde	aldehyde	NNP
cord-341050-hnuogpqn	380	2	inhibitors	inhibitor	NNS
cord-341050-hnuogpqn	381	1	Inhibition	inhibition	NN
cord-341050-hnuogpqn	381	2	of	of	IN
cord-341050-hnuogpqn	381	3	dengue	dengue	NN
cord-341050-hnuogpqn	381	4	NS2B	NS2B	NNP
cord-341050-hnuogpqn	381	5	-	-	:
cord-341050-hnuogpqn	381	6	NS3	ns3	RB
cord-341050-hnuogpqn	381	7	protease	protease	NN
cord-341050-hnuogpqn	381	8	and	and	CC
cord-341050-hnuogpqn	381	9	viral	viral	JJ
cord-341050-hnuogpqn	381	10	replication	replication	NN
cord-341050-hnuogpqn	381	11	in	in	IN
cord-341050-hnuogpqn	381	12	Vero	Vero	NNP
cord-341050-hnuogpqn	381	13	cells	cell	NNS
cord-341050-hnuogpqn	381	14	by	by	IN
cord-341050-hnuogpqn	381	15	recombinant	recombinant	JJ
cord-341050-hnuogpqn	381	16	retrocyclin-1	retrocyclin-1	NNP
cord-341050-hnuogpqn	381	17	Potent	Potent	NNP
cord-341050-hnuogpqn	381	18	and	and	CC
cord-341050-hnuogpqn	381	19	specifi	specifi	NNP
cord-341050-hnuogpqn	381	20	c	c	NNP
cord-341050-hnuogpqn	381	21	genetic	genetic	JJ
cord-341050-hnuogpqn	381	22	interference	interference	NN
cord-341050-hnuogpqn	381	23	by	by	IN
cord-341050-hnuogpqn	381	24	double	double	RB
cord-341050-hnuogpqn	381	25	-	-	HYPH
cord-341050-hnuogpqn	381	26	stranded	strand	VBN
cord-341050-hnuogpqn	381	27	RNA	RNA	NNP
cord-341050-hnuogpqn	381	28	in	in	IN
cord-341050-hnuogpqn	381	29	Caenorhabditis	Caenorhabditis	NNP
cord-341050-hnuogpqn	381	30	elegans	elegan	NNS
cord-341050-hnuogpqn	381	31	RNA	RNA	NNP
cord-341050-hnuogpqn	381	32	as	as	IN
cord-341050-hnuogpqn	381	33	a	a	DT
cord-341050-hnuogpqn	381	34	target	target	NN
cord-341050-hnuogpqn	381	35	of	of	IN
cord-341050-hnuogpqn	381	36	double	double	RB
cord-341050-hnuogpqn	381	37	-	-	HYPH
cord-341050-hnuogpqn	381	38	stranded	strand	VBN
cord-341050-hnuogpqn	381	39	RNA	rna	NN
cord-341050-hnuogpqn	381	40	-	-	HYPH
cord-341050-hnuogpqn	381	41	mediated	mediate	VBN
cord-341050-hnuogpqn	381	42	genetic	genetic	JJ
cord-341050-hnuogpqn	381	43	interference	interference	NN
cord-341050-hnuogpqn	381	44	in	in	IN
cord-341050-hnuogpqn	381	45	Caenorhabditis	Caenorhabditis	NNP
cord-341050-hnuogpqn	381	46	elegans	elegan	NNS
cord-341050-hnuogpqn	381	47	Sequence	sequence	NN
cord-341050-hnuogpqn	381	48	-	-	HYPH
cord-341050-hnuogpqn	381	49	specifi	specifi	NNP
cord-341050-hnuogpqn	381	50	c	c	NN
cord-341050-hnuogpqn	381	51	inhibition	inhibition	NN
cord-341050-hnuogpqn	381	52	of	of	IN
cord-341050-hnuogpqn	381	53	microRNA	microRNA	NNP
cord-341050-hnuogpqn	381	54	-	-	:
cord-341050-hnuogpqn	381	55	and	and	CC
cord-341050-hnuogpqn	381	56	siRNA	siRNA	NNP
cord-341050-hnuogpqn	381	57	-	-	HYPH
cord-341050-hnuogpqn	381	58	induced	induce	VBN
cord-341050-hnuogpqn	381	59	RNA	RNA	NNP
cord-341050-hnuogpqn	381	60	silencing	silence	VBG
cord-341050-hnuogpqn	381	61	Mechanisms	Mechanisms	NNPS
cord-341050-hnuogpqn	381	62	of	of	IN
cord-341050-hnuogpqn	381	63	gene	gene	NN
cord-341050-hnuogpqn	381	64	silencing	silencing	NN
cord-341050-hnuogpqn	381	65	by	by	IN
cord-341050-hnuogpqn	381	66	double	double	RB
cord-341050-hnuogpqn	381	67	-	-	HYPH
cord-341050-hnuogpqn	381	68	stranded	strand	VBN
cord-341050-hnuogpqn	381	69	RNA	RNA	NNP
cord-341050-hnuogpqn	381	70	Actively	actively	RB
cord-341050-hnuogpqn	381	71	replicating	replicate	VBG
cord-341050-hnuogpqn	381	72	West	West	NNP
cord-341050-hnuogpqn	381	73	Nile	Nile	NNP
cord-341050-hnuogpqn	381	74	virus	virus	NN
cord-341050-hnuogpqn	381	75	is	be	VBZ
cord-341050-hnuogpqn	381	76	resistant	resistant	JJ
cord-341050-hnuogpqn	381	77	to	to	IN
cord-341050-hnuogpqn	381	78	cytoplasmic	cytoplasmic	JJ
cord-341050-hnuogpqn	381	79	delivery	delivery	NN
cord-341050-hnuogpqn	381	80	of	of	IN
cord-341050-hnuogpqn	381	81	siRNA	siRNA	NNP
cord-341050-hnuogpqn	381	82	A	a	DT
cord-341050-hnuogpqn	381	83	single	single	JJ
cord-341050-hnuogpqn	381	84	siRNA	sirna	NN
cord-341050-hnuogpqn	381	85	suppresses	suppress	VBZ
cord-341050-hnuogpqn	381	86	fatal	fatal	JJ
cord-341050-hnuogpqn	381	87	encephalitis	encephalitis	RB
cord-341050-hnuogpqn	381	88	induced	induce	VBN
cord-341050-hnuogpqn	381	89	by	by	IN
cord-341050-hnuogpqn	381	90	two	two	CD
cord-341050-hnuogpqn	381	91	different	different	JJ
cord-341050-hnuogpqn	381	92	fl	fl	NNP
cord-341050-hnuogpqn	381	93	aviviruses	aviviruse	NNS
cord-341050-hnuogpqn	382	1	The	the	DT
cord-341050-hnuogpqn	382	2	utility	utility	NN
cord-341050-hnuogpqn	382	3	of	of	IN
cord-341050-hnuogpqn	382	4	siRNA	siRNA	NNP
cord-341050-hnuogpqn	382	5	transcripts	transcript	NNS
cord-341050-hnuogpqn	382	6	produced	produce	VBN
cord-341050-hnuogpqn	382	7	by	by	IN
cord-341050-hnuogpqn	382	8	RNA	RNA	NNP
cord-341050-hnuogpqn	382	9	polymerase	polymerase	NN
cord-341050-hnuogpqn	382	10	i	i	PRP
cord-341050-hnuogpqn	382	11	in	in	IN
cord-341050-hnuogpqn	382	12	down	down	RB
cord-341050-hnuogpqn	382	13	regulating	regulate	VBG
cord-341050-hnuogpqn	382	14	viral	viral	JJ
cord-341050-hnuogpqn	382	15	gene	gene	NN
cord-341050-hnuogpqn	382	16	expression	expression	NN
cord-341050-hnuogpqn	382	17	and	and	CC
cord-341050-hnuogpqn	382	18	replication	replication	NN
cord-341050-hnuogpqn	382	19	of	of	IN
cord-341050-hnuogpqn	382	20	negativeand	negativeand	JJ
cord-341050-hnuogpqn	382	21	positive	positive	JJ
cord-341050-hnuogpqn	382	22	-	-	HYPH
cord-341050-hnuogpqn	382	23	strand	strand	NN
cord-341050-hnuogpqn	382	24	RNA	RNA	NNP
cord-341050-hnuogpqn	382	25	viruses	virus	NNS
cord-341050-hnuogpqn	382	26	Expression	expression	NN
cord-341050-hnuogpqn	382	27	of	of	IN
cord-341050-hnuogpqn	382	28	vector	vector	NN
cord-341050-hnuogpqn	382	29	-	-	HYPH
cord-341050-hnuogpqn	382	30	based	base	VBN
cord-341050-hnuogpqn	382	31	small	small	JJ
cord-341050-hnuogpqn	382	32	interfering	interfere	VBG
cord-341050-hnuogpqn	382	33	RNA	RNA	NNP
cord-341050-hnuogpqn	382	34	against	against	IN
cord-341050-hnuogpqn	382	35	West	West	NNP
cord-341050-hnuogpqn	382	36	Nile	Nile	NNP
cord-341050-hnuogpqn	382	37	virus	virus	NN
cord-341050-hnuogpqn	382	38	effectively	effectively	RB
cord-341050-hnuogpqn	382	39	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	382	40	virus	virus	NN
cord-341050-hnuogpqn	382	41	replication	replication	NN
cord-341050-hnuogpqn	382	42	Inhibition	inhibition	NN
cord-341050-hnuogpqn	382	43	of	of	IN
cord-341050-hnuogpqn	382	44	West	West	NNP
cord-341050-hnuogpqn	382	45	Nile	Nile	NNP
cord-341050-hnuogpqn	382	46	virus	virus	NN
cord-341050-hnuogpqn	382	47	replication	replication	NN
cord-341050-hnuogpqn	382	48	in	in	IN
cord-341050-hnuogpqn	382	49	cells	cell	NNS
cord-341050-hnuogpqn	382	50	stably	stably	RB
cord-341050-hnuogpqn	382	51	transfected	transfecte	VBN
cord-341050-hnuogpqn	382	52	with	with	IN
cord-341050-hnuogpqn	382	53	vector	vector	NN
cord-341050-hnuogpqn	382	54	-	-	HYPH
cord-341050-hnuogpqn	382	55	based	base	VBN
cord-341050-hnuogpqn	382	56	shRNA	shrna	NN
cord-341050-hnuogpqn	382	57	expression	expression	NN
cord-341050-hnuogpqn	382	58	system	system	NN
cord-341050-hnuogpqn	382	59	Transvascular	Transvascular	NNP
cord-341050-hnuogpqn	382	60	delivery	delivery	NN
cord-341050-hnuogpqn	382	61	of	of	IN
cord-341050-hnuogpqn	382	62	small	small	JJ
cord-341050-hnuogpqn	382	63	interfering	interfere	VBG
cord-341050-hnuogpqn	382	64	RNA	RNA	NNP
cord-341050-hnuogpqn	382	65	to	to	IN
cord-341050-hnuogpqn	382	66	the	the	DT
cord-341050-hnuogpqn	382	67	central	central	JJ
cord-341050-hnuogpqn	382	68	nervous	nervous	JJ
cord-341050-hnuogpqn	382	69	system	system	NN
cord-341050-hnuogpqn	382	70	RVGpeptide	rvgpeptide	NN
cord-341050-hnuogpqn	382	71	-	-	HYPH
cord-341050-hnuogpqn	382	72	linked	link	VBN
cord-341050-hnuogpqn	382	73	trimethylated	trimethylated	JJ
cord-341050-hnuogpqn	382	74	chitosan	chitosan	NN
cord-341050-hnuogpqn	382	75	for	for	IN
cord-341050-hnuogpqn	382	76	delivery	delivery	NN
cord-341050-hnuogpqn	382	77	of	of	IN
cord-341050-hnuogpqn	382	78	siRNA	siRNA	NNP
cord-341050-hnuogpqn	382	79	to	to	IN
cord-341050-hnuogpqn	382	80	the	the	DT
cord-341050-hnuogpqn	382	81	brain	brain	NN
cord-341050-hnuogpqn	382	82	Delivery	delivery	NN
cord-341050-hnuogpqn	382	83	of	of	IN
cord-341050-hnuogpqn	382	84	antiviral	antiviral	JJ
cord-341050-hnuogpqn	382	85	small	small	JJ
cord-341050-hnuogpqn	382	86	interfering	interfere	VBG
cord-341050-hnuogpqn	382	87	RNA	RNA	NNP
cord-341050-hnuogpqn	382	88	with	with	IN
cord-341050-hnuogpqn	382	89	gold	gold	NN
cord-341050-hnuogpqn	382	90	nanoparticles	nanoparticle	NNS
cord-341050-hnuogpqn	382	91	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	382	92	dengue	dengue	NN
cord-341050-hnuogpqn	382	93	virus	virus	NN
cord-341050-hnuogpqn	382	94	infection	infection	NN
cord-341050-hnuogpqn	382	95	in	in	IN
cord-341050-hnuogpqn	382	96	vitro	vitro	FW
cord-341050-hnuogpqn	382	97	Delivery	delivery	NN
cord-341050-hnuogpqn	382	98	of	of	IN
cord-341050-hnuogpqn	382	99	multiple	multiple	JJ
cord-341050-hnuogpqn	382	100	siRNAs	sirna	NNS
cord-341050-hnuogpqn	382	101	using	use	VBG
cord-341050-hnuogpqn	382	102	lipid	lipid	NN
cord-341050-hnuogpqn	382	103	-	-	HYPH
cord-341050-hnuogpqn	382	104	coated	coat	VBN
cord-341050-hnuogpqn	382	105	PLGA	PLGA	NNP
cord-341050-hnuogpqn	382	106	nanoparticles	nanoparticle	NNS
cord-341050-hnuogpqn	382	107	for	for	IN
cord-341050-hnuogpqn	382	108	treatment	treatment	NN
cord-341050-hnuogpqn	382	109	of	of	IN
cord-341050-hnuogpqn	382	110	prostate	prostate	NN
cord-341050-hnuogpqn	382	111	cancer	cancer	NN
cord-341050-hnuogpqn	382	112	Inhibition	Inhibition	NNP
cord-341050-hnuogpqn	382	113	of	of	IN
cord-341050-hnuogpqn	382	114	West	West	NNP
cord-341050-hnuogpqn	382	115	Nile	Nile	NNP
cord-341050-hnuogpqn	382	116	virus	virus	NN
cord-341050-hnuogpqn	382	117	replication	replication	NN
cord-341050-hnuogpqn	382	118	by	by	IN
cord-341050-hnuogpqn	382	119	retrovirus	retrovirus	NN
cord-341050-hnuogpqn	382	120	-	-	HYPH
cord-341050-hnuogpqn	382	121	delivered	deliver	VBN
cord-341050-hnuogpqn	382	122	small	small	JJ
cord-341050-hnuogpqn	382	123	interfering	interfere	VBG
cord-341050-hnuogpqn	382	124	RNA	RNA	NNP
cord-341050-hnuogpqn	382	125	in	in	IN
cord-341050-hnuogpqn	382	126	human	human	JJ
cord-341050-hnuogpqn	382	127	neuroblastoma	neuroblastoma	NN
cord-341050-hnuogpqn	382	128	cells	cell	NNS
cord-341050-hnuogpqn	383	1	Alpha/	Alpha/	NNP
cord-341050-hnuogpqn	384	1	beta	beta	NN
cord-341050-hnuogpqn	384	2	interferon	interferon	NNP
cord-341050-hnuogpqn	384	3	protects	protect	VBZ
cord-341050-hnuogpqn	384	4	against	against	IN
cord-341050-hnuogpqn	384	5	lethal	lethal	JJ
cord-341050-hnuogpqn	384	6	West	West	NNP
cord-341050-hnuogpqn	384	7	Nile	Nile	NNP
cord-341050-hnuogpqn	384	8	virus	virus	NN
cord-341050-hnuogpqn	384	9	infection	infection	NN
cord-341050-hnuogpqn	384	10	by	by	IN
cord-341050-hnuogpqn	384	11	restricting	restrict	VBG
cord-341050-hnuogpqn	384	12	cellular	cellular	JJ
cord-341050-hnuogpqn	384	13	tropism	tropism	NN
cord-341050-hnuogpqn	384	14	and	and	CC
cord-341050-hnuogpqn	384	15	enhancing	enhance	VBG
cord-341050-hnuogpqn	384	16	neuronal	neuronal	JJ
cord-341050-hnuogpqn	384	17	survival	survival	NN
cord-341050-hnuogpqn	385	1	Beta	beta	NN
cord-341050-hnuogpqn	386	1	interferon	interferon	NNP
cord-341050-hnuogpqn	386	2	controls	control	VBZ
cord-341050-hnuogpqn	386	3	West	West	NNP
cord-341050-hnuogpqn	386	4	Nile	Nile	NNP
cord-341050-hnuogpqn	386	5	virus	virus	NN
cord-341050-hnuogpqn	386	6	infection	infection	NN
cord-341050-hnuogpqn	386	7	and	and	CC
cord-341050-hnuogpqn	386	8	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	386	9	in	in	IN
cord-341050-hnuogpqn	386	10	mice	mouse	NNS
cord-341050-hnuogpqn	387	1	IL-1beta	il-1beta	JJ
cord-341050-hnuogpqn	387	2	signaling	signaling	NN
cord-341050-hnuogpqn	387	3	promotes	promote	VBZ
cord-341050-hnuogpqn	387	4	CNS	CNS	NNP
cord-341050-hnuogpqn	387	5	-	-	HYPH
cord-341050-hnuogpqn	387	6	intrinsic	intrinsic	JJ
cord-341050-hnuogpqn	387	7	immune	immune	JJ
cord-341050-hnuogpqn	387	8	control	control	NN
cord-341050-hnuogpqn	387	9	of	of	IN
cord-341050-hnuogpqn	387	10	West	West	NNP
cord-341050-hnuogpqn	387	11	Nile	Nile	NNP
cord-341050-hnuogpqn	387	12	virus	virus	NN
cord-341050-hnuogpqn	387	13	infection	infection	NN
cord-341050-hnuogpqn	387	14	Abrogation	abrogation	NN
cord-341050-hnuogpqn	387	15	of	of	IN
cord-341050-hnuogpqn	387	16	macrophage	macrophage	NN
cord-341050-hnuogpqn	387	17	migration	migration	NN
cord-341050-hnuogpqn	387	18	inhibitory	inhibitory	JJ
cord-341050-hnuogpqn	387	19	factor	factor	NN
cord-341050-hnuogpqn	388	1	decreases	decrease	VBZ
cord-341050-hnuogpqn	388	2	West	West	NNP
cord-341050-hnuogpqn	388	3	Nile	Nile	NNP
cord-341050-hnuogpqn	388	4	virus	virus	NN
cord-341050-hnuogpqn	388	5	lethality	lethality	NN
cord-341050-hnuogpqn	388	6	by	by	IN
cord-341050-hnuogpqn	388	7	limiting	limit	VBG
cord-341050-hnuogpqn	388	8	viral	viral	JJ
cord-341050-hnuogpqn	388	9	neuroinvasion	neuroinvasion	NN
cord-341050-hnuogpqn	388	10	T	T	NNP
cord-341050-hnuogpqn	388	11	-	-	HYPH
cord-341050-hnuogpqn	388	12	cell	cell	NN
cord-341050-hnuogpqn	388	13	recruitment	recruitment	NN
cord-341050-hnuogpqn	388	14	and	and	CC
cord-341050-hnuogpqn	388	15	control	control	NN
cord-341050-hnuogpqn	388	16	of	of	IN
cord-341050-hnuogpqn	388	17	West	West	NNP
cord-341050-hnuogpqn	388	18	Nile	Nile	NNP
cord-341050-hnuogpqn	388	19	virus	virus	NN
cord-341050-hnuogpqn	388	20	encephalitis	encephalitis	RB
cord-341050-hnuogpqn	388	21	A	a	DT
cord-341050-hnuogpqn	388	22	role	role	NN
cord-341050-hnuogpqn	388	23	for	for	IN
cord-341050-hnuogpqn	388	24	the	the	DT
cord-341050-hnuogpqn	388	25	chemokine	chemokine	NN
cord-341050-hnuogpqn	388	26	RANTES	rante	NNS
cord-341050-hnuogpqn	388	27	in	in	IN
cord-341050-hnuogpqn	388	28	regulating	regulate	VBG
cord-341050-hnuogpqn	388	29	CD8	CD8	NNP
cord-341050-hnuogpqn	388	30	T	T	NNP
cord-341050-hnuogpqn	388	31	cell	cell	NN
cord-341050-hnuogpqn	388	32	responses	response	NNS
cord-341050-hnuogpqn	388	33	during	during	IN
cord-341050-hnuogpqn	388	34	chronic	chronic	JJ
cord-341050-hnuogpqn	388	35	viral	viral	JJ
cord-341050-hnuogpqn	388	36	infection	infection	NN
cord-341050-hnuogpqn	388	37	Chemokine	Chemokine	NNP
cord-341050-hnuogpqn	388	38	receptor	receptor	NN
cord-341050-hnuogpqn	388	39	CCR5	CCR5	NNP
cord-341050-hnuogpqn	388	40	promotes	promote	VBZ
cord-341050-hnuogpqn	388	41	leukocyte	leukocyte	NN
cord-341050-hnuogpqn	388	42	traffi	traffi	NNP
cord-341050-hnuogpqn	388	43	cking	cking	JJ
cord-341050-hnuogpqn	388	44	to	to	IN
cord-341050-hnuogpqn	388	45	the	the	DT
cord-341050-hnuogpqn	388	46	brain	brain	NN
cord-341050-hnuogpqn	388	47	and	and	CC
cord-341050-hnuogpqn	388	48	survival	survival	NN
cord-341050-hnuogpqn	388	49	in	in	IN
cord-341050-hnuogpqn	389	1	West	West	NNP
cord-341050-hnuogpqn	389	2	Nile	Nile	NNP
cord-341050-hnuogpqn	389	3	virus	virus	NN
cord-341050-hnuogpqn	389	4	infection	infection	NN
cord-341050-hnuogpqn	389	5	IL-22	IL-22	NNP
cord-341050-hnuogpqn	389	6	signaling	signal	VBG
cord-341050-hnuogpqn	389	7	contributes	contribute	VBZ
cord-341050-hnuogpqn	389	8	to	to	IN
cord-341050-hnuogpqn	389	9	West	West	NNP
cord-341050-hnuogpqn	389	10	Nile	Nile	NNP
cord-341050-hnuogpqn	389	11	encephalitis	encephalitis	NN
cord-341050-hnuogpqn	389	12	pathogenesis	pathogenesis	NN
cord-341050-hnuogpqn	389	13	Clinical	clinical	JJ
cord-341050-hnuogpqn	389	14	-	-	:
cord-341050-hnuogpqn	389	15	and	and	CC
cord-341050-hnuogpqn	389	16	cost	cost	NN
cord-341050-hnuogpqn	389	17	-	-	HYPH
cord-341050-hnuogpqn	389	18	effectiveness	effectiveness	NN
cord-341050-hnuogpqn	389	19	of	of	IN
cord-341050-hnuogpqn	389	20	pegylated	pegylated	JJ
cord-341050-hnuogpqn	389	21	interferon	interferon	NNP
cord-341050-hnuogpqn	389	22	alfa	alfa	NNP
cord-341050-hnuogpqn	389	23	in	in	IN
cord-341050-hnuogpqn	389	24	the	the	DT
cord-341050-hnuogpqn	389	25	treatment	treatment	NN
cord-341050-hnuogpqn	389	26	of	of	IN
cord-341050-hnuogpqn	389	27	chronic	chronic	JJ
cord-341050-hnuogpqn	389	28	hepatitis	hepatitis	NN
cord-341050-hnuogpqn	389	29	C	C	NNP
cord-341050-hnuogpqn	389	30	:	:	:
cord-341050-hnuogpqn	389	31	a	a	DT
cord-341050-hnuogpqn	389	32	systematic	systematic	JJ
cord-341050-hnuogpqn	389	33	review	review	NN
cord-341050-hnuogpqn	389	34	and	and	CC
cord-341050-hnuogpqn	389	35	economic	economic	JJ
cord-341050-hnuogpqn	389	36	evaluation	evaluation	NN
cord-341050-hnuogpqn	390	1	The	the	DT
cord-341050-hnuogpqn	390	2	NS5	ns5	JJ
cord-341050-hnuogpqn	390	3	protein	protein	NN
cord-341050-hnuogpqn	390	4	of	of	IN
cord-341050-hnuogpqn	390	5	the	the	DT
cord-341050-hnuogpqn	390	6	virulent	virulent	JJ
cord-341050-hnuogpqn	390	7	West	West	NNP
cord-341050-hnuogpqn	390	8	Nile	Nile	NNP
cord-341050-hnuogpqn	390	9	virus	virus	NN
cord-341050-hnuogpqn	390	10	NY99	NY99	NNP
cord-341050-hnuogpqn	390	11	strain	strain	NN
cord-341050-hnuogpqn	390	12	is	be	VBZ
cord-341050-hnuogpqn	390	13	a	a	DT
cord-341050-hnuogpqn	390	14	potent	potent	JJ
cord-341050-hnuogpqn	390	15	antagonist	antagonist	NN
cord-341050-hnuogpqn	390	16	of	of	IN
cord-341050-hnuogpqn	390	17	type	type	NN
cord-341050-hnuogpqn	391	1	I	-PRON-	PRP
cord-341050-hnuogpqn	391	2	interferon	interferon	NN
cord-341050-hnuogpqn	391	3	-	-	HYPH
cord-341050-hnuogpqn	391	4	mediated	mediate	VBN
cord-341050-hnuogpqn	391	5	JAK	JAK	NNP
cord-341050-hnuogpqn	391	6	-	-	HYPH
cord-341050-hnuogpqn	391	7	STAT	STAT	NNP
cord-341050-hnuogpqn	391	8	signaling	signal	VBG
cord-341050-hnuogpqn	391	9	Flavivirus	Flavivirus	NNP
cord-341050-hnuogpqn	391	10	antagonism	antagonism	NN
cord-341050-hnuogpqn	391	11	of	of	IN
cord-341050-hnuogpqn	391	12	type	type	NN
cord-341050-hnuogpqn	392	1	I	-PRON-	PRP
cord-341050-hnuogpqn	392	2	interferon	interferon	VBP
cord-341050-hnuogpqn	392	3	signaling	signal	VBG
cord-341050-hnuogpqn	392	4	reveals	reveal	VBZ
cord-341050-hnuogpqn	392	5	prolidase	prolidase	NN
cord-341050-hnuogpqn	392	6	as	as	IN
cord-341050-hnuogpqn	392	7	a	a	DT
cord-341050-hnuogpqn	392	8	regulator	regulator	NN
cord-341050-hnuogpqn	392	9	of	of	IN
cord-341050-hnuogpqn	392	10	IFNAR1	ifnar1	NN
cord-341050-hnuogpqn	392	11	surface	surface	NN
cord-341050-hnuogpqn	392	12	expression	expression	NN
cord-341050-hnuogpqn	392	13	Interferon	interferon	NN
cord-341050-hnuogpqn	392	14	-	-	HYPH
cord-341050-hnuogpqn	392	15	lambda	lambda	NNP
cord-341050-hnuogpqn	392	16	restricts	restrict	VBZ
cord-341050-hnuogpqn	392	17	West	West	NNP
cord-341050-hnuogpqn	392	18	Nile	Nile	NNP
cord-341050-hnuogpqn	392	19	virus	virus	NN
cord-341050-hnuogpqn	392	20	neuroinvasion	neuroinvasion	NN
cord-341050-hnuogpqn	392	21	by	by	IN
cord-341050-hnuogpqn	392	22	tightening	tighten	VBG
cord-341050-hnuogpqn	393	1	the	the	DT
cord-341050-hnuogpqn	393	2	blood	blood	NN
cord-341050-hnuogpqn	393	3	-	-	HYPH
cord-341050-hnuogpqn	393	4	brain	brain	NN
cord-341050-hnuogpqn	393	5	barrier	barrier	NN
cord-341050-hnuogpqn	393	6	Cyclosporine	Cyclosporine	NNP
cord-341050-hnuogpqn	393	7	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	393	8	fl	fl	NNP
cord-341050-hnuogpqn	393	9	avivirus	avivirus	NN
cord-341050-hnuogpqn	393	10	replication	replication	NN
cord-341050-hnuogpqn	393	11	through	through	IN
cord-341050-hnuogpqn	393	12	blocking	block	VBG
cord-341050-hnuogpqn	393	13	the	the	DT
cord-341050-hnuogpqn	393	14	interaction	interaction	NN
cord-341050-hnuogpqn	393	15	between	between	IN
cord-341050-hnuogpqn	393	16	host	host	NN
cord-341050-hnuogpqn	393	17	cyclophilins	cyclophilin	NNS
cord-341050-hnuogpqn	393	18	and	and	CC
cord-341050-hnuogpqn	393	19	viral	viral	JJ
cord-341050-hnuogpqn	393	20	NS5	ns5	JJ
cord-341050-hnuogpqn	393	21	protein	protein	NN
cord-341050-hnuogpqn	394	1	The	the	DT
cord-341050-hnuogpqn	394	2	ubiquitin	ubiquitin	NN
cord-341050-hnuogpqn	394	3	-	-	HYPH
cord-341050-hnuogpqn	394	4	proteasome	proteasome	VBN
cord-341050-hnuogpqn	394	5	pathway	pathway	NN
cord-341050-hnuogpqn	394	6	is	be	VBZ
cord-341050-hnuogpqn	394	7	important	important	JJ
cord-341050-hnuogpqn	394	8	for	for	IN
cord-341050-hnuogpqn	394	9	dengue	dengue	NN
cord-341050-hnuogpqn	394	10	virus	virus	NN
cord-341050-hnuogpqn	394	11	infection	infection	NN
cord-341050-hnuogpqn	394	12	in	in	IN
cord-341050-hnuogpqn	394	13	primary	primary	JJ
cord-341050-hnuogpqn	394	14	human	human	JJ
cord-341050-hnuogpqn	394	15	endothelial	endothelial	NN
cord-341050-hnuogpqn	394	16	cells	cell	NNS
cord-341050-hnuogpqn	394	17	Dengue	dengue	NN
cord-341050-hnuogpqn	394	18	virus	virus	NN
cord-341050-hnuogpqn	394	19	serotype	serotype	NN
cord-341050-hnuogpqn	394	20	infection	infection	NN
cord-341050-hnuogpqn	394	21	specifi	specifi	NNP
cord-341050-hnuogpqn	394	22	es	es	XX
cord-341050-hnuogpqn	394	23	the	the	DT
cord-341050-hnuogpqn	394	24	activation	activation	NN
cord-341050-hnuogpqn	394	25	of	of	IN
cord-341050-hnuogpqn	394	26	the	the	DT
cord-341050-hnuogpqn	394	27	unfolded	unfolded	JJ
cord-341050-hnuogpqn	394	28	protein	protein	NN
cord-341050-hnuogpqn	394	29	response	response	NN
cord-341050-hnuogpqn	394	30	Mycophenolic	Mycophenolic	NNP
cord-341050-hnuogpqn	394	31	acid	acid	NN
cord-341050-hnuogpqn	394	32	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	394	33	dengue	dengue	NN
cord-341050-hnuogpqn	394	34	virus	virus	NN
cord-341050-hnuogpqn	394	35	infection	infection	NN
cord-341050-hnuogpqn	394	36	by	by	IN
cord-341050-hnuogpqn	394	37	preventing	prevent	VBG
cord-341050-hnuogpqn	394	38	replication	replication	NN
cord-341050-hnuogpqn	394	39	of	of	IN
cord-341050-hnuogpqn	394	40	viral	viral	JJ
cord-341050-hnuogpqn	394	41	RNA	RNA	NNP
cord-341050-hnuogpqn	395	1	The	the	DT
cord-341050-hnuogpqn	395	2	predominant	predominant	JJ
cord-341050-hnuogpqn	395	3	mechanism	mechanism	NN
cord-341050-hnuogpqn	395	4	by	by	IN
cord-341050-hnuogpqn	395	5	which	which	WDT
cord-341050-hnuogpqn	395	6	ribavirin	ribavirin	NNP
cord-341050-hnuogpqn	395	7	exerts	exert	VBZ
cord-341050-hnuogpqn	395	8	its	-PRON-	PRP$
cord-341050-hnuogpqn	395	9	antiviral	antiviral	JJ
cord-341050-hnuogpqn	395	10	activity	activity	NN
cord-341050-hnuogpqn	395	11	in	in	IN
cord-341050-hnuogpqn	395	12	vitro	vitro	FW
cord-341050-hnuogpqn	395	13	against	against	IN
cord-341050-hnuogpqn	395	14	fl	fl	NNP
cord-341050-hnuogpqn	395	15	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	395	16	and	and	CC
cord-341050-hnuogpqn	395	17	paramyxoviruses	paramyxoviruses	NNP
cord-341050-hnuogpqn	395	18	is	be	VBZ
cord-341050-hnuogpqn	395	19	mediated	mediate	VBN
cord-341050-hnuogpqn	395	20	by	by	IN
cord-341050-hnuogpqn	395	21	inhibition	inhibition	NN
cord-341050-hnuogpqn	395	22	of	of	IN
cord-341050-hnuogpqn	395	23	IMP	imp	JJ
cord-341050-hnuogpqn	395	24	dehydrogenase	dehydrogenase	NN
cord-341050-hnuogpqn	395	25	Increased	increase	VBD
cord-341050-hnuogpqn	395	26	pathogenicity	pathogenicity	NN
cord-341050-hnuogpqn	395	27	of	of	IN
cord-341050-hnuogpqn	395	28	West	West	NNP
cord-341050-hnuogpqn	395	29	Nile	Nile	NNP
cord-341050-hnuogpqn	395	30	virus	virus	NN
cord-341050-hnuogpqn	395	31	(	(	-LRB-
cord-341050-hnuogpqn	395	32	WNV	WNV	NNP
cord-341050-hnuogpqn	395	33	)	)	-RRB-
cord-341050-hnuogpqn	395	34	by	by	IN
cord-341050-hnuogpqn	395	35	glycosylation	glycosylation	NN
cord-341050-hnuogpqn	395	36	of	of	IN
cord-341050-hnuogpqn	395	37	envelope	envelope	NN
cord-341050-hnuogpqn	395	38	protein	protein	NN
cord-341050-hnuogpqn	395	39	and	and	CC
cord-341050-hnuogpqn	395	40	seroprevalence	seroprevalence	NN
cord-341050-hnuogpqn	395	41	of	of	IN
cord-341050-hnuogpqn	395	42	WNV	WNV	NNP
cord-341050-hnuogpqn	395	43	in	in	IN
cord-341050-hnuogpqn	395	44	wild	wild	JJ
cord-341050-hnuogpqn	395	45	birds	bird	NNS
cord-341050-hnuogpqn	395	46	in	in	IN
cord-341050-hnuogpqn	395	47	Far	far	JJ
cord-341050-hnuogpqn	395	48	Eastern	eastern	JJ
cord-341050-hnuogpqn	395	49	Russia	Russia	NNP
cord-341050-hnuogpqn	395	50	Glycosylation	Glycosylation	NNP
cord-341050-hnuogpqn	395	51	of	of	IN
cord-341050-hnuogpqn	395	52	the	the	DT
cord-341050-hnuogpqn	395	53	West	West	NNP
cord-341050-hnuogpqn	395	54	Nile	Nile	NNP
cord-341050-hnuogpqn	395	55	virus	virus	NN
cord-341050-hnuogpqn	395	56	envelope	envelope	NN
cord-341050-hnuogpqn	395	57	protein	protein	NN
cord-341050-hnuogpqn	395	58	increases	increase	NNS
cord-341050-hnuogpqn	395	59	in	in	IN
cord-341050-hnuogpqn	395	60	vivo	vivo	NN
cord-341050-hnuogpqn	395	61	and	and	CC
cord-341050-hnuogpqn	395	62	in	in	IN
cord-341050-hnuogpqn	395	63	vitro	vitro	FW
cord-341050-hnuogpqn	395	64	viral	viral	JJ
cord-341050-hnuogpqn	395	65	multiplication	multiplication	NN
cord-341050-hnuogpqn	395	66	in	in	IN
cord-341050-hnuogpqn	395	67	birds	bird	NNS
cord-341050-hnuogpqn	395	68	Multiple	multiple	JJ
cord-341050-hnuogpqn	395	69	amino	amino	NN
cord-341050-hnuogpqn	395	70	acid	acid	NN
cord-341050-hnuogpqn	395	71	changes	change	NNS
cord-341050-hnuogpqn	395	72	at	at	IN
cord-341050-hnuogpqn	395	73	the	the	DT
cord-341050-hnuogpqn	395	74	fi	fi	NN
cord-341050-hnuogpqn	395	75	rst	rst	NN
cord-341050-hnuogpqn	395	76	glycosylation	glycosylation	NN
cord-341050-hnuogpqn	395	77	motif	motif	NN
cord-341050-hnuogpqn	395	78	in	in	IN
cord-341050-hnuogpqn	395	79	NS1	ns1	NN
cord-341050-hnuogpqn	395	80	protein	protein	NN
cord-341050-hnuogpqn	395	81	of	of	IN
cord-341050-hnuogpqn	395	82	West	West	NNP
cord-341050-hnuogpqn	395	83	Nile	Nile	NNP
cord-341050-hnuogpqn	395	84	virus	virus	NN
cord-341050-hnuogpqn	395	85	are	be	VBP
cord-341050-hnuogpqn	395	86	necessary	necessary	JJ
cord-341050-hnuogpqn	395	87	for	for	IN
cord-341050-hnuogpqn	395	88	complete	complete	JJ
cord-341050-hnuogpqn	395	89	attenuation	attenuation	NN
cord-341050-hnuogpqn	395	90	for	for	IN
cord-341050-hnuogpqn	395	91	mouse	mouse	NN
cord-341050-hnuogpqn	395	92	neuroinvasiveness	neuroinvasiveness	WRB
cord-341050-hnuogpqn	395	93	U18666A	U18666A	NNP
cord-341050-hnuogpqn	395	94	,	,	,
cord-341050-hnuogpqn	395	95	an	an	DT
cord-341050-hnuogpqn	395	96	intra	intra	JJ
cord-341050-hnuogpqn	395	97	-	-	JJ
cord-341050-hnuogpqn	395	98	cellular	cellular	JJ
cord-341050-hnuogpqn	395	99	cholesterol	cholesterol	NN
cord-341050-hnuogpqn	395	100	transport	transport	NN
cord-341050-hnuogpqn	395	101	inhibitor	inhibitor	NN
cord-341050-hnuogpqn	395	102	,	,	,
cord-341050-hnuogpqn	395	103	inhibits	inhibit	VBZ
cord-341050-hnuogpqn	395	104	dengue	dengue	NN
cord-341050-hnuogpqn	395	105	virus	virus	NN
cord-341050-hnuogpqn	395	106	entry	entry	NN
cord-341050-hnuogpqn	395	107	and	and	CC
cord-341050-hnuogpqn	395	108	replication	replication	NN
cord-341050-hnuogpqn	395	109	West	West	NNP
cord-341050-hnuogpqn	395	110	Nile	Nile	NNP
cord-341050-hnuogpqn	395	111	virus	virus	NN
cord-341050-hnuogpqn	395	112	replication	replication	NN
cord-341050-hnuogpqn	395	113	requires	require	VBZ
cord-341050-hnuogpqn	395	114	fatty	fatty	JJ
cord-341050-hnuogpqn	395	115	acid	acid	NN
cord-341050-hnuogpqn	395	116	synthesis	synthesis	NN
cord-341050-hnuogpqn	395	117	but	but	CC
cord-341050-hnuogpqn	395	118	is	be	VBZ
cord-341050-hnuogpqn	395	119	independent	independent	JJ
cord-341050-hnuogpqn	395	120	on	on	IN
cord-341050-hnuogpqn	395	121	phosphatidylinositol-4-phosphate	phosphatidylinositol-4-phosphate	NNP
cord-341050-hnuogpqn	395	122	lipids	lipid	NNS
cord-341050-hnuogpqn	396	1	West	West	NNP
cord-341050-hnuogpqn	396	2	Nile	Nile	NNP
cord-341050-hnuogpqn	396	3	virus	virus	NN
cord-341050-hnuogpqn	396	4	entry	entry	NN
cord-341050-hnuogpqn	396	5	requires	require	VBZ
cord-341050-hnuogpqn	396	6	cholesterol	cholesterol	NN
cord-341050-hnuogpqn	396	7	-	-	HYPH
cord-341050-hnuogpqn	396	8	rich	rich	JJ
cord-341050-hnuogpqn	396	9	membrane	membrane	NN
cord-341050-hnuogpqn	396	10	microdomains	microdomain	NNS
cord-341050-hnuogpqn	396	11	and	and	CC
cord-341050-hnuogpqn	396	12	is	be	VBZ
cord-341050-hnuogpqn	396	13	independent	independent	JJ
cord-341050-hnuogpqn	396	14	of	of	IN
cord-341050-hnuogpqn	396	15	alphavbeta3	alphavbeta3	NN
cord-341050-hnuogpqn	396	16	integrin	integrin	JJ
cord-341050-hnuogpqn	397	1	Dhiraj	Dhiraj	NNP
cord-341050-hnuogpqn	397	2	Acharya	Acharya	NNP
cord-341050-hnuogpqn	397	3	and	and	CC
cord-341050-hnuogpqn	397	4	Fengwei	Fengwei	NNP
cord-341050-hnuogpqn	397	5	Bai	Bai	NNP
cord-341050-hnuogpqn	397	6	Discovery	Discovery	NNP
cord-341050-hnuogpqn	397	7	of	of	IN
cord-341050-hnuogpqn	397	8	insect	insect	NN
cord-341050-hnuogpqn	397	9	and	and	CC
cord-341050-hnuogpqn	398	1	human	human	JJ
cord-341050-hnuogpqn	398	2	dengue	dengue	NNP
cord-341050-hnuogpqn	398	3	virus	virus	NN
cord-341050-hnuogpqn	398	4	host	host	NN
cord-341050-hnuogpqn	398	5	factors	factor	NNS
cord-341050-hnuogpqn	399	1	Exploitation	exploitation	NN
cord-341050-hnuogpqn	399	2	of	of	IN
cord-341050-hnuogpqn	399	3	cellular	cellular	JJ
cord-341050-hnuogpqn	399	4	pathways	pathway	NNS
cord-341050-hnuogpqn	399	5	by	by	IN
cord-341050-hnuogpqn	399	6	dengue	dengue	NN
cord-341050-hnuogpqn	399	7	virus	virus	NN
cord-341050-hnuogpqn	399	8	Host	host	NN
cord-341050-hnuogpqn	399	9	factors	factor	NNS
cord-341050-hnuogpqn	399	10	involved	involve	VBN
cord-341050-hnuogpqn	399	11	in	in	IN
cord-341050-hnuogpqn	399	12	West	West	NNP
cord-341050-hnuogpqn	399	13	Nile	Nile	NNP
cord-341050-hnuogpqn	399	14	virus	virus	NN
cord-341050-hnuogpqn	399	15	replication	replication	NN
cord-341050-hnuogpqn	399	16	Characterization	characterization	NN
cord-341050-hnuogpqn	399	17	of	of	IN
cord-341050-hnuogpqn	399	18	dengue	dengue	NN
cord-341050-hnuogpqn	399	19	virus	virus	NN
cord-341050-hnuogpqn	399	20	resistance	resistance	NN
cord-341050-hnuogpqn	399	21	to	to	IN
cord-341050-hnuogpqn	399	22	brequinar	brequinar	VB
cord-341050-hnuogpqn	399	23	in	in	IN
cord-341050-hnuogpqn	399	24	cell	cell	NN
cord-341050-hnuogpqn	399	25	culture	culture	NN
cord-341050-hnuogpqn	400	1	Inhibition	inhibition	NN
cord-341050-hnuogpqn	400	2	of	of	IN
cord-341050-hnuogpqn	400	3	dengue	dengue	NN
cord-341050-hnuogpqn	400	4	virus	virus	NN
cord-341050-hnuogpqn	400	5	through	through	IN
cord-341050-hnuogpqn	400	6	suppression	suppression	NN
cord-341050-hnuogpqn	400	7	of	of	IN
cord-341050-hnuogpqn	400	8	host	host	NN
cord-341050-hnuogpqn	400	9	pyrimidine	pyrimidine	NN
cord-341050-hnuogpqn	400	10	biosynthesis	biosynthesis	NN
cord-341050-hnuogpqn	400	11	Novel	Novel	NNP
cord-341050-hnuogpqn	400	12	imino	imino	NN
cord-341050-hnuogpqn	400	13	sugar	sugar	NN
cord-341050-hnuogpqn	400	14	derivatives	derivative	NNS
cord-341050-hnuogpqn	400	15	demonstrate	demonstrate	VBP
cord-341050-hnuogpqn	400	16	potent	potent	JJ
cord-341050-hnuogpqn	400	17	antiviral	antiviral	JJ
cord-341050-hnuogpqn	400	18	activity	activity	NN
cord-341050-hnuogpqn	400	19	against	against	IN
cord-341050-hnuogpqn	400	20	fl	fl	NNP
cord-341050-hnuogpqn	400	21	aviviruses	aviviruses	NNP
cord-341050-hnuogpqn	400	22	Mechanism	Mechanism	NNP
cord-341050-hnuogpqn	400	23	of	of	IN
cord-341050-hnuogpqn	400	24	West	West	NNP
cord-341050-hnuogpqn	400	25	Nile	Nile	NNP
cord-341050-hnuogpqn	400	26	virus	virus	NN
cord-341050-hnuogpqn	400	27	neuroinvasion	neuroinvasion	NN
cord-341050-hnuogpqn	400	28	:	:	:
cord-341050-hnuogpqn	400	29	a	a	DT
cord-341050-hnuogpqn	400	30	critical	critical	JJ
cord-341050-hnuogpqn	400	31	appraisal	appraisal	NN
cord-341050-hnuogpqn	400	32	Nocodazole	Nocodazole	NNP
cord-341050-hnuogpqn	400	33	delays	delay	VBZ
cord-341050-hnuogpqn	400	34	viral	viral	JJ
cord-341050-hnuogpqn	400	35	entry	entry	NN
cord-341050-hnuogpqn	400	36	into	into	IN
cord-341050-hnuogpqn	400	37	the	the	DT
cord-341050-hnuogpqn	400	38	brain	brain	NN
cord-341050-hnuogpqn	400	39	following	follow	VBG
cord-341050-hnuogpqn	400	40	footpad	footpad	NN
cord-341050-hnuogpqn	400	41	inoculation	inoculation	NN
cord-341050-hnuogpqn	400	42	with	with	IN
cord-341050-hnuogpqn	400	43	West	West	NNP
cord-341050-hnuogpqn	400	44	Nile	Nile	NNP
cord-341050-hnuogpqn	400	45	virus	virus	NN
cord-341050-hnuogpqn	400	46	in	in	IN
cord-341050-hnuogpqn	400	47	mice	mouse	NNS
cord-341050-hnuogpqn	400	48	Identifi	Identifi	NNP
cord-341050-hnuogpqn	400	49	cation	cation	NN
cord-341050-hnuogpqn	400	50	of	of	IN
cord-341050-hnuogpqn	400	51	cis	cis	NNP
cord-341050-hnuogpqn	400	52	-	-	HYPH
cord-341050-hnuogpqn	400	53	acting	act	VBG
cord-341050-hnuogpqn	400	54	nucleotides	nucleotide	NNS
cord-341050-hnuogpqn	400	55	and	and	CC
cord-341050-hnuogpqn	400	56	a	a	DT
cord-341050-hnuogpqn	400	57	structural	structural	JJ
cord-341050-hnuogpqn	400	58	feature	feature	NN
cord-341050-hnuogpqn	400	59	in	in	IN
cord-341050-hnuogpqn	400	60	West	West	NNP
cord-341050-hnuogpqn	400	61	Nile	Nile	NNP
cord-341050-hnuogpqn	400	62	virus	virus	NN
cord-341050-hnuogpqn	400	63	3′-terminus	3′-terminus	CD
cord-341050-hnuogpqn	400	64	RNA	RNA	NNP
cord-341050-hnuogpqn	400	65	that	that	WDT
cord-341050-hnuogpqn	400	66	facilitate	facilitate	VBP
cord-341050-hnuogpqn	400	67	viral	viral	JJ
cord-341050-hnuogpqn	400	68	minus	minus	IN
cord-341050-hnuogpqn	400	69	strand	strand	NN
cord-341050-hnuogpqn	400	70	RNA	RNA	NNP
cord-341050-hnuogpqn	400	71	synthesis	synthesis	NN
cord-341050-hnuogpqn	400	72	Cell	cell	NN
cord-341050-hnuogpqn	400	73	proteins	protein	NNS
cord-341050-hnuogpqn	401	1	TIA-1	tia-1	IN
cord-341050-hnuogpqn	401	2	and	and	CC
cord-341050-hnuogpqn	401	3	TIAR	TIAR	NNP
cord-341050-hnuogpqn	401	4	interact	interact	VBP
cord-341050-hnuogpqn	401	5	with	with	IN
cord-341050-hnuogpqn	401	6	the	the	DT
cord-341050-hnuogpqn	401	7	3′	3′	CD
cord-341050-hnuogpqn	401	8	stem	stem	NN
cord-341050-hnuogpqn	401	9	-	-	HYPH
cord-341050-hnuogpqn	401	10	loop	loop	NN
cord-341050-hnuogpqn	401	11	of	of	IN
cord-341050-hnuogpqn	401	12	the	the	DT
cord-341050-hnuogpqn	401	13	West	West	NNP
cord-341050-hnuogpqn	401	14	Nile	Nile	NNP
cord-341050-hnuogpqn	401	15	virus	virus	NN
cord-341050-hnuogpqn	402	1	complementary	complementary	JJ
cord-341050-hnuogpqn	402	2	minus	minus	JJ
cord-341050-hnuogpqn	402	3	-	-	HYPH
cord-341050-hnuogpqn	402	4	strand	strand	NN
cord-341050-hnuogpqn	402	5	RNA	RNA	NNP
cord-341050-hnuogpqn	402	6	and	and	CC
cord-341050-hnuogpqn	402	7	facilitate	facilitate	VB
cord-341050-hnuogpqn	402	8	virus	virus	NN
cord-341050-hnuogpqn	402	9	replication	replication	NN
cord-341050-hnuogpqn	402	10	BHK	BHK	NNP
cord-341050-hnuogpqn	402	11	cell	cell	NN
cord-341050-hnuogpqn	402	12	proteins	protein	NNS
cord-341050-hnuogpqn	402	13	that	that	WDT
cord-341050-hnuogpqn	402	14	bind	bind	VBP
cord-341050-hnuogpqn	402	15	to	to	IN
cord-341050-hnuogpqn	402	16	the	the	DT
cord-341050-hnuogpqn	402	17	3′	3′	CD
cord-341050-hnuogpqn	402	18	stem	stem	NN
cord-341050-hnuogpqn	402	19	-	-	HYPH
cord-341050-hnuogpqn	402	20	loop	loop	NN
cord-341050-hnuogpqn	402	21	structure	structure	NN
cord-341050-hnuogpqn	402	22	of	of	IN
cord-341050-hnuogpqn	402	23	the	the	DT
cord-341050-hnuogpqn	402	24	West	West	NNP
cord-341050-hnuogpqn	402	25	Nile	Nile	NNP
cord-341050-hnuogpqn	402	26	virus	virus	NN
cord-341050-hnuogpqn	402	27	genome	genome	NN
cord-341050-hnuogpqn	402	28	RNA	RNA	NNP
cord-341050-hnuogpqn	402	29	Interaction	Interaction	NNP
cord-341050-hnuogpqn	402	30	between	between	IN
cord-341050-hnuogpqn	402	31	the	the	DT
cord-341050-hnuogpqn	402	32	cellular	cellular	JJ
cord-341050-hnuogpqn	402	33	protein	protein	NN
cord-341050-hnuogpqn	402	34	eEF1A	eef1a	NN
cord-341050-hnuogpqn	402	35	and	and	CC
cord-341050-hnuogpqn	402	36	the	the	DT
cord-341050-hnuogpqn	402	37	3′-terminal	3′-terminal	CD
cord-341050-hnuogpqn	402	38	stem	stem	NN
cord-341050-hnuogpqn	402	39	-	-	HYPH
cord-341050-hnuogpqn	402	40	loop	loop	NN
cord-341050-hnuogpqn	402	41	of	of	IN
cord-341050-hnuogpqn	402	42	West	West	NNP
cord-341050-hnuogpqn	402	43	Nile	Nile	NNP
cord-341050-hnuogpqn	402	44	virus	virus	NN
cord-341050-hnuogpqn	402	45	genomic	genomic	JJ
cord-341050-hnuogpqn	402	46	RNA	RNA	NNP
cord-341050-hnuogpqn	403	1	facilitates	facilitate	VBZ
cord-341050-hnuogpqn	403	2	viral	viral	JJ
cord-341050-hnuogpqn	403	3	minus	minus	JJ
cord-341050-hnuogpqn	403	4	-	-	HYPH
cord-341050-hnuogpqn	403	5	strand	strand	NN
cord-341050-hnuogpqn	403	6	RNA	RNA	NNP
cord-341050-hnuogpqn	403	7	synthesis	synthesis	NN
cord-341050-hnuogpqn	403	8	Cell	cell	NN
cord-341050-hnuogpqn	403	9	proteins	protein	NNS
cord-341050-hnuogpqn	403	10	bind	bind	VBP
cord-341050-hnuogpqn	403	11	specifi	specifi	NN
cord-341050-hnuogpqn	403	12	cally	cally	RB
cord-341050-hnuogpqn	403	13	to	to	IN
cord-341050-hnuogpqn	403	14	West	West	NNP
cord-341050-hnuogpqn	403	15	Nile	Nile	NNP
cord-341050-hnuogpqn	403	16	virus	virus	NN
cord-341050-hnuogpqn	404	1	minus	minus	JJ
cord-341050-hnuogpqn	404	2	-	-	HYPH
cord-341050-hnuogpqn	404	3	strand	strand	NN
cord-341050-hnuogpqn	404	4	3′	3′	CD
cord-341050-hnuogpqn	404	5	stem	stem	NN
cord-341050-hnuogpqn	404	6	-	-	HYPH
cord-341050-hnuogpqn	404	7	loop	loop	NN
cord-341050-hnuogpqn	404	8	RNA	RNA	NNP
cord-341050-hnuogpqn	404	9	Cost	cost	NN
cord-341050-hnuogpqn	404	10	-	-	HYPH
cord-341050-hnuogpqn	404	11	effectiveness	effectiveness	NN
cord-341050-hnuogpqn	404	12	of	of	IN
cord-341050-hnuogpqn	404	13	West	West	NNP
cord-341050-hnuogpqn	404	14	Nile	Nile	NNP
cord-341050-hnuogpqn	404	15	virus	virus	NN
cord-341050-hnuogpqn	404	16	vaccination	vaccination	NN
cord-341050-hnuogpqn	404	17	Prospects	prospect	NNS
cord-341050-hnuogpqn	404	18	for	for	IN
cord-341050-hnuogpqn	404	19	development	development	NN
cord-341050-hnuogpqn	404	20	of	of	IN
cord-341050-hnuogpqn	404	21	a	a	DT
cord-341050-hnuogpqn	404	22	vaccine	vaccine	NN
cord-341050-hnuogpqn	404	23	against	against	IN
cord-341050-hnuogpqn	404	24	the	the	DT
cord-341050-hnuogpqn	404	25	West	West	NNP
cord-341050-hnuogpqn	404	26	Nile	Nile	NNP
cord-341050-hnuogpqn	404	27	virus	virus	NN
cord-341050-hnuogpqn	404	28	Immune	immune	VBP
cord-341050-hnuogpqn	404	29	responses	response	NNS
cord-341050-hnuogpqn	404	30	to	to	IN
cord-341050-hnuogpqn	404	31	an	an	DT
cord-341050-hnuogpqn	404	32	attenuated	attenuated	JJ
cord-341050-hnuogpqn	404	33	West	West	NNP
cord-341050-hnuogpqn	404	34	Nile	Nile	NNP
cord-341050-hnuogpqn	404	35	virus	virus	NN
cord-341050-hnuogpqn	404	36	NS4B	NS4B	NNP
cord-341050-hnuogpqn	404	37	-	-	HYPH
cord-341050-hnuogpqn	404	38	P38	P38	NNP
cord-341050-hnuogpqn	404	39	G	G	NNP
cord-341050-hnuogpqn	404	40	mutant	mutant	JJ
cord-341050-hnuogpqn	404	41	strain	strain	NN
cord-341050-hnuogpqn	404	42	Phase	Phase	NNP
cord-341050-hnuogpqn	404	43	II	II	NNP
cord-341050-hnuogpqn	404	44	,	,	,
cord-341050-hnuogpqn	405	1	randomized	randomized	JJ
cord-341050-hnuogpqn	405	2	,	,	,
cord-341050-hnuogpqn	405	3	double	double	JJ
cord-341050-hnuogpqn	405	4	-	-	HYPH
cord-341050-hnuogpqn	405	5	blind	blind	JJ
cord-341050-hnuogpqn	405	6	,	,	,
cord-341050-hnuogpqn	405	7	placebo	placebo	NN
cord-341050-hnuogpqn	405	8	-	-	HYPH
cord-341050-hnuogpqn	405	9	controlled	control	VBN
cord-341050-hnuogpqn	405	10	,	,	,
cord-341050-hnuogpqn	405	11	multicenter	multicenter	JJ
cord-341050-hnuogpqn	405	12	study	study	NN
cord-341050-hnuogpqn	405	13	to	to	TO
cord-341050-hnuogpqn	405	14	investigate	investigate	VB
cord-341050-hnuogpqn	405	15	the	the	DT
cord-341050-hnuogpqn	405	16	immunogenicity	immunogenicity	NN
cord-341050-hnuogpqn	405	17	and	and	CC
cord-341050-hnuogpqn	405	18	safety	safety	NN
cord-341050-hnuogpqn	405	19	of	of	IN
cord-341050-hnuogpqn	405	20	a	a	DT
cord-341050-hnuogpqn	405	21	West	West	NNP
cord-341050-hnuogpqn	405	22	Nile	Nile	NNP
cord-341050-hnuogpqn	405	23	virus	virus	NN
cord-341050-hnuogpqn	405	24	vaccine	vaccine	NN
cord-341050-hnuogpqn	405	25	in	in	IN
cord-341050-hnuogpqn	405	26	healthy	healthy	JJ
cord-341050-hnuogpqn	405	27	adults	adult	NNS
cord-341050-hnuogpqn	406	1	The	the	DT
cord-341050-hnuogpqn	406	2	authors	author	NNS
cord-341050-hnuogpqn	406	3	are	be	VBP
cord-341050-hnuogpqn	406	4	very	very	RB
cord-341050-hnuogpqn	406	5	thankful	thankful	JJ
cord-341050-hnuogpqn	406	6	to	to	IN
cord-341050-hnuogpqn	406	7	Dr.	Dr.	NNP
cord-341050-hnuogpqn	406	8	Dobrivoje	Dobrivoje	NNP
cord-341050-hnuogpqn	406	9	S.	S.	NNP
cord-341050-hnuogpqn	406	10	Stokic	Stokic	NNP
cord-341050-hnuogpqn	406	11	for	for	IN
cord-341050-hnuogpqn	406	12	his	-PRON-	PRP$
cord-341050-hnuogpqn	406	13	critical	critical	JJ
cord-341050-hnuogpqn	406	14	reading	reading	NN
cord-341050-hnuogpqn	406	15	.	.	.
cord-341050-hnuogpqn	407	1	This	this	DT
cord-341050-hnuogpqn	407	2	work	work	NN
cord-341050-hnuogpqn	407	3	is	be	VBZ
cord-341050-hnuogpqn	407	4	supported	support	VBN
cord-341050-hnuogpqn	407	5	by	by	IN
cord-341050-hnuogpqn	407	6	funding	fund	VBG
cord-341050-hnuogpqn	407	7	from	from	IN
cord-341050-hnuogpqn	407	8	Wilson	Wilson	NNP
cord-341050-hnuogpqn	407	9	Research	Research	NNP
cord-341050-hnuogpqn	407	10	Foundation	Foundation	NNP
cord-341050-hnuogpqn	407	11	,	,	,
cord-341050-hnuogpqn	407	12	Jackson	Jackson	NNP
cord-341050-hnuogpqn	407	13	,	,	,
cord-341050-hnuogpqn	407	14	MS	MS	NNP
cord-341050-hnuogpqn	407	15	,	,	,
cord-341050-hnuogpqn	407	16	NIH	NIH	NNP
cord-341050-hnuogpqn	407	17	R15AI113706	R15AI113706	NNP
cord-341050-hnuogpqn	407	18	,	,	,
cord-341050-hnuogpqn	407	19	and	and	CC
cord-341050-hnuogpqn	407	20	the	the	DT
cord-341050-hnuogpqn	407	21	University	University	NNP
cord-341050-hnuogpqn	407	22	of	of	IN
cord-341050-hnuogpqn	407	23	Southern	Southern	NNP
cord-341050-hnuogpqn	407	24	Mississippi	Mississippi	NNP
cord-341050-hnuogpqn	407	25	.	.	.