id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001347-ssrs0cwf	Michaelis, Martin	Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza a virus activity exerted by baicalein and biochanin A	2014-06-23		.txt	text/plain	1995	125	43	title: Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza a virus activity exerted by baicalein and biochanin A Recently, we showed that the structurally similar flavonoids baicalein and biochanin A inhibit highly pathogenic avian H5N1 influenza A virus replication by different mechanisms in A549 lung cells. Next, we investigated whether the reduction of baicalein-or biochanin A-induced enhanced ROS levels in H5N1-infected A549 cells by NAC influences the antiviral effects of these flavonoids. Notably, NAC also inhibited baicalein-and biochanin A-induced oxidative stress in H5N1-infected primary human monocytederived macrophages but did not affect H5N1 replication in this cell type (Figure 3 ). These findings emphasise that flavonoids, a class of natural compounds known to exert anti-influenza effects [16] [17] [18] [19] 28] , induce a complex range of pharmacological actions by which they modify influenza A virus replication including highly pathogenic avian H5N1 strains. Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells	./cache/cord-001347-ssrs0cwf.txt	./txt/cord-001347-ssrs0cwf.txt