id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-034321-ohjik0pf	Vorobjeva, N. V.	NETosis: Molecular Mechanisms, Role in Physiology and Pathology	2020-10-27		.txt	text/plain	7605	432	43	NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of modified chromatin decorated with bactericidal proteins from granules and cytoplasm. NETosis includes release of the granule components into the cytosol, modification of histones leading to chromatin decondensation, destruction of the nuclear envelope, as well as formation of pores in the plasma membrane. 1178 Abbreviations: ARDS, acute respiratory distress syndrome; CGD, chronic granulomatous disease; COPD, chronic obstructive pulmonary disease; GSDMD, gasdermin D; LPS, lipopolysaccharide of the bacterial wall; MPO, myeloper oxidase; mPTP, nonselective mitochondrial permeability tran sition pore; NE, neutrophil elastase; NETs, Neutrophil Extra cellular Traps; PCD, programmed cell death; PKC, protein kinase C; PMA, phorbol 12 myristate 13 acetate; ROS, reac tive oxygen species. At the same time, we also showed that in neutrophils isolated from the blood of patients with X linked CGD formation of NETs in response to A23187 depended on the enhanced gener ation of mtROS without participation of NADPH oxi dase [16] .	./cache/cord-034321-ohjik0pf.txt	./txt/cord-034321-ohjik0pf.txt