id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335676-7ak53hto	Meftahi, Gholam Hossein	The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”	2020-06-11		.txt	text/plain	8208	435	43	It seems that "cytokine storm" phenomenon in elderly patients with severe COVID-19 infection, is associated with many age-related pathophysiologic processes, including alteration of angiotensin-converting enzyme 2 (ACE2) receptor expression [9] , excess ROS production [10] , alteration of autophagy [11] , the inflammatory phenotype of senescent cell activity, particularly adipose tissue [12] , and immune-senescence [13] , as well as lack of vitamin D content [14] . As shown in Fig. 2 , several factors, including alteration of ACE2 receptor expression, excess reactive oxygen species (ROS) production, senescent adipocytes activity, alteration of autophagy and mitophagy, immune-senescent, as well as vitamin D (VD) deficiency, may associate "inflame-aging" to cytokine storm in elderly patients of COVID-19. Furthermore, the lack of VD in aged subjects is associated with the pro-inflammatory phenotype of immune cells, leading to likely increasing the risk of elderly adults with chronic mild inflammation condition [122] .	./cache/cord-335676-7ak53hto.txt	./txt/cord-335676-7ak53hto.txt