key: cord-257805-pcp3qgn0 authors: Mehta, Harsh; Ivanovic, Sasa; Cronin, Amanda; VanBrunt, Lindsey; Mistry, Nirav; Miller, Richard; Yodice, Paul; Rezai, Fariborz title: Novel coronavirus-related acute respiratory distress syndrome in a patient with twin pregnancy: A case report date: 2020-05-16 journal: Case Rep Womens Health DOI: 10.1016/j.crwh.2020.e00220 sha: doc_id: 257805 cord_uid: pcp3qgn0 We present the case of a 39-year-old woman, G1P0, who had conceived twins via in-vitro fertilization, who presented at 27 weeks of gestation with nasal congestion and dry cough for 7 days. On presentation, her physical examination was benign, except for sinus tachycardia, and she was oxygenating adequately on room air. Laboratory studies were unremarkable, except a PCR test positive for SARS-COV2, and a CT scan of her chest showed bilateral multi-focal ground-glass opacities. A fetal non-stress test was reassuring. She was treated with intravenous fluids, ceftriaxone, azithromycin, and hydroxychloroquine. During her hospital stay, she developed progressively worsening respiratory failure, initially requiring non-invasive ventilation, and subsequently progressed to acute respiratory distress syndrome requiring mechanical ventilation. She then suffered from sudden hypoxemia and hemodynamic collapse, on maximal ventilatory support, prompting an emergency cesarean section at bedside. This led to rapid stabilization of hemodynamic parameters, and of her overall respiratory status. Both the twins were born prematurely, and one of them tested positive for SARS-COV2. vitro fertilization, who presented at 27 weeks of gestation with nasal congestion and dry cough for 7 days. On presentation, her physical examination was benign, except for sinus tachycardia, and she was oxygenating adequately on room air. Laboratory studies were unremarkable, except a PCR test positive for SARS-COV2, and a CT scan of her chest showed bilateral multi-focal ground-glass opacities. A fetal non-stress test was reassuring. She was treated with intravenous fluids, ceftriaxone, azithromycin, and hydroxychloroquine. During her hospital stay, she developed progressively worsening respiratory failure, initially requiring non-invasive ventilation, and subsequently progressed to acute respiratory distress syndrome requiring mechanical ventilation. She then suffered from sudden hypoxemia and hemodynamic collapse, on maximal ventilatory support, prompting an emergency cesarean section at bedside. This led to rapid stabilization of hemodynamic parameters, and of her overall respiratory status. Since its first reported case in China, more than 4 Coronaviruses are known pathogens and have previously been responsible for epidemics caused by severe acute respiratory syndrome coronavirus (SARS-CoV1) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV) [2] . Pregnancy is a unique immunologic state, where the maternal immune system is modulated to allow tolerance to paternally derived fetal antigens, thereby leading to an increased susceptibility to infections, especially pneumonia [3] . In one study, up to 25% of pregnant women with pneumonia required critical care services, including mechanical ventilation [4] . Overall, pregnant women are more susceptible to respiratory pathogens, and might be at an increased risk for COVID-19 [5] . During the previous SARS and MERS outbreaks, pregnant women were reported to have poorer outcomes than the general population [4] . We report a case of a high-risk pregnant woman who developed respiratory failure associated with COVID-19, and had a favorable outcome postdelivery. We also report possible vertical transmission of COVID-19 infection in this case. A 39-year-old African American pregnant woman (G1P0) presented to the emergency department with a 7-day history of nasal congestion and dry cough. She was at 27 J o u r n a l P r e -p r o o f Journal Pre-proof weeks of ultrasound-confirmed in-utero gestation with diamniotic-dichorionic twins, achieved via in-vitro fertilization. Two days prior to presentation, she started experiencing chest discomfort and shortness of breath. She eventually developed fever, which prompted her visit to the emergency department. She had no known medical problems, and her current pregnancy had been uneventful. She denied recent travel. Her only medications included prenatal vitamins and aspirin. On arrival at the emergency department, she had a temperature of 98.3°F (36.8°C), a heart rate of 121 beats/minute, blood pressure of 135/105 mmHg, respiratory rate of 20 breaths/minute, and an oxygen saturation of 96% on room air. On physical examination, her lungs were clear to auscultation bilaterally, while a cardiac exam revealed tachycardia with a regular rhythm and normal heart sounds. Abdominal exam was consistent with 27 weeks of gestation. Bilateral lower extremities were symmetric without cyanosis or edema. A fetal non-stress test (NST) showed moderate heart rate variability and no decelerations for both the twins. Laboratory tests were mostly unremarkable, as shown in table 1. Tests for influenza and other respiratory pathogens were negative. A nasopharyngeal swab for COVID-19 RT-PCR was obtained. A CT angiogram of her chest was negative for pulmonary embolism (PE), but revealed multifocal patchy ground-glass opacities in both her lungs, consistent with multi-lobar pneumonia. She was started on intravenous fluids, ceftriaxone and azithromycin. Her COVID-19 test came back as positive after 27 hours. Hydroxychloroquine was added, and betamethasone was administered for fetal lung maturity. Over the next two days, her J o u r n a l P r e -p r o o f respiratory status worsened, leading to a requirement for supplemental oxygen. On day 4, she became tachypneic and started requiring increasing amounts of oxygen, for which the FiO2 was increased to 80%, delivered at 35L/min via a high-flow nasal cannula. She was then transferred to the intensive care unit (ICU) and required endotracheal intubation and mechanical ventilation. Settings were adjusted to a tidal volume of 500 ml/breath, respiratory rate of 18 breaths/minute, positive end-expiratory pressure (PEEP) of 10 cm H2O and FiO2 of 70%. A repeat chest X-ray showed worsening bilateral pulmonary infiltrates, raising concern for development of acute respiratory distress syndrome (ARDS). Over the next two days, she required maximal ventilator support, with a FiO2 of 100%. Her blood pressure also dropped to 92/52 mmHg, for which was started on norepinephrine. Fetal heart tracings were recorded daily, which continued to be reassuring up to this point. On day 7, her condition rapidly deteriorated, with oxygen saturation dropping to 80%; hence PEEP was increased to 14 cm H2O, while maintaining an FiO2 of 100%. Chest x-ray showed worsening bilateral alveolar infiltrates, consistent with progressing ARDS. During this time, her vasopressor requirements also increased significantly, and the norepinephrine was increased to 30 mcg/min to achieve a mean arterial pressure (MAP) of 65 mmHg. Due to rapid maternal decompensation, we decided to deliver the fetuses. A classical C-section was performed at the patient's bedside, and two fetuses were delivered successfully. Baby A was female, weighed 925 g, and had APGAR scores of 1, 3 and 6 at 1, 5 and 10 minutes respectively. Baby B was male, weighed 1050 g, and had APGAR scores of 5, 6 and 6 at 1, 5 and 10 minutes respectively. The neonates were immediately transferred to the neonatal intensive care unit (NICU). Journal Pre-proof Immediately after uterine decompression, hemodynamic parameters improved significantly. Norepinephrine was titrated down to 6 mcg/min and the patient gradually weaned off. FiO2 was decreased to 40% within an hour, while PEEP was gradually decreased to 10 cm H2O. Details of her vasopressor and ventilator requirements are outlined in figure 1. On day 9, she was successfully extubated and eventually transferred out of the ICU. She was weaned off supplemental oxygen and was soon discharged home. The neonates were tested for COVID-19. Twin A tested positive 72 hours after birth; however, she did not exhibit any infectious symptoms. Twin B tested negative at 72 hours after birth. His course was complicated by development of alveolar hemorrhage, which was attributed to preterm delivery. He required invasive mechanical ventilation for the same. Our patient suffered from a progressively worsening respiratory failure, culminating in ARDS. High circulating volume, low albumin levels, increased capillary leak and development of a pro-inflammatory state have all been proposed as mechanisms predisposing pregnant women to ARDS [3] . Following the American Thoracic Society's guidelines for management of ARDS, our patient was mechanically ventilated while a low tidal volume was delivered along with a high PEEP to maintain an oxygen saturation of more than 92% [11] . Of note, on the seventh day of hospitalization, our patient's condition rapidly J o u r n a l P r e -p r o o f Journal Pre-proof deteriorated, and she required increasing ventilatory and vasopressor support. This deterioration was attributed to rapidly worsening ARDS. However, it is also important to identify that the high PEEP, which was originally applied to combat ARDS, could have led to increased intrathoracic pressure, ultimately leading to decreased venous return and cardiac output [11] . Furthermore, in pregnancy, despite hypervolemia, the effect of the gravid uterus on inferior vena cava can compromise venous return, which, in combination with a high PEEP, can precipitate hypotension [12] . And hence, the fact that after delivery, her hemodynamic parameters rapidly improved can be attributed to the reduction in oxygen consumption and effective deliverance of preload, thereby leading to an improvement in cardiac output, and ultimately, in gas exchange. While prone positioning has been shown to reduce mortality in patients with severe ARDS by means of improved lung recruitment, data regarding its utility in pregnancy is sparse [13, 14, 15] . Due to this reason, we decided against pronating the patient at the time of her rapid deterioration. In the data available in pregnant patients from the previous coronavirus outbreaks, no vertical transmission was reported [4] . In a recently published review of 37 pregnant mothers with COVID-19 and their 38 newborns, no vertical transmission was reported. Of these, all neonates with confirmed COVID-19 had been infected after birth, via droplet or contact transmission [10]. In our case, the patient was intubated at the time of delivery, making droplet transmission unlikely. The babies were delivered via C-section, eliminating the possibility of fetal contact with maternal feces, which has been reported as a mode of transmission. During delivery, appropriate sterilization techniques and precautions were utilized, and any maternal contact with the neonates was avoided. Both the neonates were transferred to the NICU immediately after birth. They were not breastfed, and appropriate aerosol and contact precautions were utilized during their handling in the NICU. Twin A tested positive and Twin B tested negative for COVID-19 at 72 hours. Due to the reasons above, we believe that Twin A tested positive due to vertical transmission. We acknowledge that there are limitations to our theory. Firstly, the placenta and umbilical cord blood were not tested for COVID-19 and, secondly, vertical transmission would have affected both twins, but Twin B, in our case, tested negative. In conclusion, our knowledge regarding the disease course of COVID-19 during pregnancy is limited to the data available from previous epidemics of SARS-CoV1 and MERS-CoV infections. COVID-19 has so far proven to be a highly contagious and lethal infection that can lead to rapidly worsening respiratory failure and death in the general population. Our case reflects that pregnant women are certainly as susceptible, if not more, and, hence, these patients should be closely followed by a multidisciplinary team of physicians. Prearranged plans for urgent delivery and neonatal resuscitation should be put in place, in anticipation of spontaneous labor or sudden maternal or fetal decline. While the vertical transmission of infection has not been reported until now, our case prompts us to think that it could certainly be possible and further research is warranted on the subject. Harsh Mehta contributed to project conceptualization, and writing and editing of the manuscript. Sasa Ivanovic contributed to editing of the manuscript. Amanda Cronin contributed to editing of the manuscript. Lindsay VanBrunt contributed to editing of the manuscript. Nirav Mistry contributed to critical review of the manuscript. Richard Miller contributed to critical review of the manuscript. Paul Yodice contributed to critical review of the manuscript. Fariborz Rezai contributed to editing and critical review of the manuscript. The authors declare that they have no conflict of interest regarding the publication of this case report. The authors declare that they did not receive any funding for their work in the production of this manuscript. Obtained. This case report was peer reviewed. 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