key: cord-269555-29t956ik authors: Zaconeta, Alberto; Heinen, Bruna Gabriel; Moreira Salles, Yvina Vilela; Egidio da Costa Matsunaga, Michelle title: Letter to the editor“SARS-CoV-2: What prevents this highly contagious virus from reaching the fetus?” date: 2020-09-22 journal: Placenta DOI: 10.1016/j.placenta.2020.09.063 sha: doc_id: 269555 cord_uid: 29t956ik nan transmission of SARS-CoV-2. After discussing anatomical and molecular differences between 36 the alveolar-capillary and syncytium-capillary barriers, the authors presented the well-37 considered hypothesis that the absence of caveolin expression in the syncytium is one of the 38 most important mechanisms preventing the transplacental passage of this virus (1) . Building on 39 their masterful analysis, we would like to extend the discussion to another important risk factor 40 for vertical transmission, namely viral load in blood. Wang Factors preventing 55 materno-fetal transmission of SARS-CoV-2 Detection of SARS-CoV-2 in 58 different types of clinical specimens Clinical features of patients 61 infected with 2019 novel coronavirus in Wuhan SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not 65 associated with infectious virus The trinity of COVID-19: immunity, 68 inflammation and intervention