key: cord-274439-y9jrdg5n
authors: Aoyama, Kazuyoshi; Heath, Anna; Yang, Alan; Maynes, Jason T.; Petroz, Guy; Robertson, James; Mc Donnell, Conor; Velummailum, Russanthy; Bond, Elizabeth; Pechlivanoglou, Petros
title: Estimating the risk of SARS-CoV-2 transmission to pediatric anesthesiologists: a microsimulation model
date: 2020-07-27
journal: Can J Anaesth
DOI: 10.1007/s12630-020-01771-9
sha: 
doc_id: 274439
cord_uid: y9jrdg5n

nan

produce estimates. Our scenarios draw upon the daily cases of COVID-19 infections in the Greater Toronto Area, Canada, derived from Government of Ontario (https:// covid-19.ontario.ca/index.html). A Through the interface, users can define inputs such as surgical statistics, including percent change of surgical caseload, and constraint on the number of available N95 respirators to model expected resource utilization at the individual hospital level, community level, or provincial level.

Beginning on 16 March 2020, our quaternary-care children's hospital performed only emergent and urgent surgeries (e.g., cancer surgery), including 236 cases during the first three weeks after the pandemic was declared. This is compared with a total of 1,578 similar cases during the same three-week period in 2019. We estimated that cancelling elective surgeries during those three weeks reduced the cumulative incidence of SARS-CoV-2 transmission to an anesthesiologist by more than six times (2.1% with cancellation compared with 13.5% without cancellation) (Figure) .

The microsimulation model applies only to the pediatric population since the incidence of symptoms in children who are COVID-19 positive appears to be different from that in adults. 1 Instead of reuse of N95 respirators, extended use of N95 respirators was assumed (i.e., an anesthesiologist wearing the same N95 respirator for all cases during their shift). We assumed the use of regular surgical masks if the stock of N95 respirators was depleted. 5 Although we considered aerosol transmission and environmental contamination of SARS-CoV-2 in the model, we did not account for transmission risks among HCWs in operating rooms, which is our future work. Instead of adjusting the duration of each surgery, we employed a fixed risk of transmission to an anesthesiologist conducting an airway management. The user can tune the transmission risk in the model when new data emerge. We incorporated our hospital's preoperative screening strategy of SARS-CoV-2 into the model with diagnostic accuracy.

The first priority in a circumstance of unprecedented stress such as the COVID-19 pandemic is to maintain HCW safety so healthcare systems can provide necessary patient care. This comes with the cost of possibly extending surgical waiting time beyond what is considered safe, which may then result in an elective surgery becoming emergent. We hope this interface will aid clinicians, administrators, and policymakers in the decision-making process involving resuming elective surgeries to optimize patient care during the COVID-19 pandemic. After external validation of the model, the interface could be utilized for a possible second wave of the COVID-19 pandemic and a similar situation in a future pandemic.

Disclosures None. Editorial responsibility This submission was handled by Dr. Hilary P. Grocott, Editor-in-Chief, Canadian Journal of Anesthesia.

Ethical approval The current study was approved by the Research Ethics Board of the Hospital for Sick Children on 16 April 2020, REB number: 1000070090. 

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State-transition modeling: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-3

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