key: cord-292650-i95upz10
authors: Marafini, Irene; Salvatori, Silvia; Sena, Giorgia; Calabrese, Emma; Biancone, Livia; Monteleone, Giovanni
title: LOW FREQUENCY OF COVID-19 IN INFLAMMATORY BOWEL DISEASES
date: 2020-06-13
journal: Dig Liver Dis
DOI: 10.1016/j.dld.2020.06.007
sha: 
doc_id: 292650
cord_uid: i95upz10

nan

After its first description in December 2019, Covid-19, an infectious respiratory disease caused by the novel coronavirus SARS-CoV-2 (1), has spread throughout the world and on March 11, 2020 the World Health Organization declared it a pandemic. The SARS-CoV-2 infection is more frequent in elderly and in subjects with co-existing pathologies and weakened immune system. The risk of infection or death due to Covid-19 in patients with inflammatory bowel diseases (IBD) is unknown at this stage. However, it has been presumed that IBD patients who are on steroids, immunosuppressive drugs or biologics could be more susceptible to SARS-CoV-2 infection, as these therapies are associated with increased risk of viral infections (2) .

To gain entry into the cells SARS-CoV-2 uses angiotensin-converting enzyme 2, a protein that is highly expressed in the human gut (3, 4) . An analysis of patients with SARS-CoV-2 infection showed that some patients experienced gastrointestinal symptoms/signs and the virus was identified in stool samples of infected patients. Viral RNA was present in the stool of over 50% of patients and, even after testing negative for SARS-CoV-2 in respiratory samples, nearly one fifth of the patients remained positive for the virus in stool samples (5, 6) . These findings suggest that the course of SARS-CoV-2 infection may involve cells of the gastrointestinal tract, a finding of importance for patients with IBD.

We here examined the frequency of symptoms/signs suggestive of Covid-19 in IBD patients and assessed the risk of SARS-CoV-2 infection in IBD.

This was an observational study including IBD patients regularly followed in our tertiary referral centre at the "Tor Vergata University Hospital", Rome, Italy. Like many countries worldwide, Italy has been placed under lockdown as Covid-19 cases surge in our country since February 2020.

Consequently, the scheduled follow-up visits in the IBD centres were cancelled or postponed and the patients have had the possibility to communicate with the IBD team through a dedicated phone number. During the calls, we recorded any symptom/sign suggestive of Covid-19 as well as information about direct contacts with subjects known to be affected by SARS-CoV-2 and data relative to the admission of the patients to the hospital for undergoing a nasopharyngeal swab to identify carriers of SARS-CoV-2. Clinical activity and management of the IBD patients were also monitored. All patients had provided their informed consent for the use of personal and clinical data for scientific purposes, and no patient refused to participate.

The study variables were summarized descriptively using numbers and percentages for discrete variables, while median and range were used for continuous variables. Cumulative incidence of SARS-CoV-2 infection in IBD was calculated dividing the positive cases by the overall population of IBD patients enrolled for the study. Cumulative incidence of laboratoryconfirmed SARS-CoV-2 infection in the Italian population was extracted from data of the Italian Health Minister (www.salute.gov). Incidence rate of SARS-CoV-2 in the IBD population was obtained with the direct method using the general Italian population as standard. Results were presented as odds ratios (OR) and their 95% confidence intervals (CI). Up to April 30 2020, more than 205463 cases of SARS-CoV-2 infection have been diagnosed in Italy, accounting for 0,3% of the total population. Although, we need more robust epidemiological data to draw a conclusion regarding the incidence rate of Covid-19 in IBD, our findings suggest that IBD patients are not at increased risk of Covid-19 as compared with the general population. Indeed, after more than 2 months from the first Covid-19 patient diagnosed in Italy, only 3 out of our 672 patients (0,44%) were infected by SARS-CoV-2. Approximately one sixth of our patients, who had direct contacts with either infected patients or individuals living in high risk geographical areas or were themselves travelling to such regions, were negative for SARS-CoV-2 and/or remain asymptomatic.

We are aware that the present study has some limitations. It is likely that the incidence of SARS-CoV-2 infection in our IBD population is underestimated as the majority of the patients did not underwent rhino-pharyngeal swab. However, in this context, it is noteworthy that such a diagnostic test was not provided to the general Italian population unless there were reasons to suspect SARS-CoV-2 infection. Thus, it is unlikely this limitation have had a major impact on the comparison of incidences. We restricted our analysis to the IBD patients scheduled to receive a visit during the study period and, therefore, this cohort could be not representative of our IBD population, which comprises more than 3000 patients. However, our data are in line with those Marafini et al. 5

published recently by Norsa and colleagues, who reported no case of SARS-CoV-2 infection in a cohort of IBD patients living in a high-risk area of Northern Italy (7). We did not attempt to assess risk factors for SARS-CoV-2 infection in IBD, as the only 3 cases documented in our study prevented the use of logistic regression models.

Notably, more than one third of our patients were receiving biologics and all of them experienced no Covid-19-related symptoms thus supporting the hypothesis that such drugs do not increase the risk of Covid-19 (8, 9) .

Based upon these data, we feel IBD patients should be encouraged to continue their treatment even during Covid-19 outbreak in order to prevent disease flares and IBD-associated 

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