key: cord-339352-c9uh8vjx authors: Islam, Muhammad Torequl title: Environmental Integrants Affecting the Spreadability of SARS-CoV-12 date: 2020-07-28 journal: Food Environ Virol DOI: 10.1007/s12560-020-09435-z sha: doc_id: 339352 cord_uid: c9uh8vjx nan kill about 10,000 viral particles within 15 min (Lai et al. 2005) . Therefore, the stem inhalation during the novel coronavirus disease 2019 (COVID-19) may work through this way. The SARS-CoV-2 can be inactivated completely using common fixatives used in laboratory, ultraviolet light, alkaline (pH > 12) or acidic (pH < 3) conditions (Darnell et al. 2004) . The virus is stable for 3 weeks at room temperature (20 to 25 °C or 68 to 77 °F) in a liquid environment. It spreads rapidly in cities and regions of the world where average temperatures have been around 5-11 °C (41-52 °F) and relative humidity has been low. Among the environmental integrants, air is playing a pivotal role to spread this virus from one person to the others. Air pollution causes weakening our immune system, reduces the ability to fight against infectious agents. Suspended particles may carry the virus particles that remain in the air. A correlation between the COVID-19 mortality rates and high levels of air pollution has been seen in Italy and USA. A small increases in fine particulate matter (e.g., PM2.5) have been found to increase the SARS-CoV-2 transmission. For example, an increase of just one microgram per cubic metre corresponded to a 15% increase in COVID-19 deaths (BBC Future 2020b). Recently, the WHO has declared the SARS-CoV-2 as an airborne virus. Water either transmits the CoVs in human still remains controversial. The SARS-CoVs can survive in water and remain infectious for long periods (days to weeks), therefore, these may affect people and other animals if aerosols are generated (Casanova et al. 2009; Gundy et al. 2009 ). It has been demonstrated that SARS-CoVs have low stability in the environment, very sensitive to oxidants (e.g., chlorine) and are inactivated significantly faster in water. However, SARS-CoV-2 has been found in the fecal samples and anal swabs of some patients, therefore, there is a possibility of fecal-oral (including waterborne) transmission of this virus (Rosa et al. 2020) . Moreover, nCoV-19 is evident to infect human small intestinal enterocytes (Zang et al. 2020 ) and has been demonstrated to be found on the human ocular surface (Zhou et al. 2020 ). The natural adsorbents, including clay, charcoal, and clay minerals showed 99.99% adsorption of SARS-CoV-2 (Robson 2020). The minerals may act against SARS-CoV-2, including selenium (Hiffler and Rakotoambinina 2020) and zinc (Skalny et al. 2020) . In contrary, iron-containing enzymes are essential for the viruses, including SARS-CoV-2 to complete their replication process. Therefore, iron chelation therapy might be an alternative option for the COVID-19 patients (Liu et al. 2020) . Moreover, medicinal plants or their derivatives are also evident to act against SARS-CoV-2 (Aanouz et al. 2020; Islam et al. 2020) . It is clear that, to date, we do not have even a single remedy for SARS-CoV-2 infection. However, along with the other preventive measures if we can manage the abovementioned environmental constraints properly, it should be possible to fight against the pandemic COVID-19. Additionally, it is also necessary to study all the environmental components that affecting the survival, replication, spreadability or transmission and pathogenicity of SARS-CoV-2 in human and other animals. Moroccan medicinal plants as inhibitors of COVID-19: Computational investigations Will warm weather really kill off Covid-19? 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Interim guidance TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection Conflict of interest The author declare that have no conflict of interest.