id sid tid token lemma pos cord-004862-yv76yvy5 1 1 key key JJ cord-004862-yv76yvy5 2 1 : : : cord-004862-yv76yvy5 2 2 cord-004862-yv76yvy5 cord-004862-yv76yvy5 NNS cord-004862-yv76yvy5 2 3 authors author NNS cord-004862-yv76yvy5 2 4 : : : cord-004862-yv76yvy5 2 5 Demers Demers NNP cord-004862-yv76yvy5 2 6 , , , cord-004862-yv76yvy5 2 7 G. G. NNP cord-004862-yv76yvy5 2 8 William William NNP cord-004862-yv76yvy5 2 9 ; ; : cord-004862-yv76yvy5 2 10 Matunis Matunis NNP cord-004862-yv76yvy5 2 11 , , , cord-004862-yv76yvy5 2 12 Michael Michael NNP cord-004862-yv76yvy5 2 13 J. J. NNP cord-004862-yv76yvy5 2 14 ; ; : cord-004862-yv76yvy5 2 15 Hardison Hardison NNP cord-004862-yv76yvy5 2 16 , , , cord-004862-yv76yvy5 2 17 Ross Ross NNP cord-004862-yv76yvy5 2 18 C. C. NNP cord-004862-yv76yvy5 2 19 title title NN cord-004862-yv76yvy5 2 20 : : : cord-004862-yv76yvy5 3 1 The the DT cord-004862-yv76yvy5 3 2 L1 L1 NNP cord-004862-yv76yvy5 3 3 family family NN cord-004862-yv76yvy5 3 4 of of IN cord-004862-yv76yvy5 3 5 long long RB cord-004862-yv76yvy5 3 6 interspersed intersperse VBN cord-004862-yv76yvy5 3 7 repetitive repetitive JJ cord-004862-yv76yvy5 3 8 DNA dna NN cord-004862-yv76yvy5 3 9 in in IN cord-004862-yv76yvy5 3 10 rabbits rabbit NNS cord-004862-yv76yvy5 3 11 : : : cord-004862-yv76yvy5 3 12 Sequence sequence NN cord-004862-yv76yvy5 3 13 , , , cord-004862-yv76yvy5 3 14 copy copy NN cord-004862-yv76yvy5 3 15 number number NN cord-004862-yv76yvy5 3 16 , , , cord-004862-yv76yvy5 3 17 conserved conserve VBN cord-004862-yv76yvy5 3 18 open open JJ cord-004862-yv76yvy5 3 19 reading reading NN cord-004862-yv76yvy5 3 20 frames frame NNS cord-004862-yv76yvy5 3 21 , , , cord-004862-yv76yvy5 3 22 and and CC cord-004862-yv76yvy5 3 23 similarity similarity NN cord-004862-yv76yvy5 3 24 to to IN cord-004862-yv76yvy5 3 25 keratin keratin NN cord-004862-yv76yvy5 3 26 date date NN cord-004862-yv76yvy5 3 27 : : : cord-004862-yv76yvy5 3 28 1989 1989 CD cord-004862-yv76yvy5 3 29 journal journal NNP cord-004862-yv76yvy5 3 30 : : : cord-004862-yv76yvy5 4 1 J J NNP cord-004862-yv76yvy5 4 2 Mol Mol NNP cord-004862-yv76yvy5 4 3 Evol Evol NNP cord-004862-yv76yvy5 4 4 DOI doi NN cord-004862-yv76yvy5 4 5 : : : cord-004862-yv76yvy5 5 1 10.1007 10.1007 CD cord-004862-yv76yvy5 5 2 / / SYM cord-004862-yv76yvy5 5 3 bf02106177 bf02106177 NN cord-004862-yv76yvy5 5 4 sha sha NNP cord-004862-yv76yvy5 5 5 : : : cord-004862-yv76yvy5 6 1 ae5dbcbf679a830e8a0c021339476a42c8285a08 ae5dbcbf679a830e8a0c021339476a42c8285a08 NNP cord-004862-yv76yvy5 6 2 doc_id doc_id CD cord-004862-yv76yvy5 6 3 : : : cord-004862-yv76yvy5 6 4 4862 4862 CD cord-004862-yv76yvy5 7 1 cord_uid cord_uid NNS cord-004862-yv76yvy5 7 2 : : : cord-004862-yv76yvy5 7 3 yv76yvy5 yv76yvy5 XX cord-004862-yv76yvy5 8 1 The the DT cord-004862-yv76yvy5 8 2 L1 L1 NNP cord-004862-yv76yvy5 8 3 family family NN cord-004862-yv76yvy5 8 4 of of IN cord-004862-yv76yvy5 8 5 long long RB cord-004862-yv76yvy5 8 6 interspersed intersperse VBN cord-004862-yv76yvy5 8 7 repetitive repetitive JJ cord-004862-yv76yvy5 8 8 DNA dna NN cord-004862-yv76yvy5 8 9 in in IN cord-004862-yv76yvy5 8 10 the the DT cord-004862-yv76yvy5 8 11 rabbit rabbit NN cord-004862-yv76yvy5 8 12 genome genome NN cord-004862-yv76yvy5 8 13 ( ( -LRB- cord-004862-yv76yvy5 8 14 L1Oc L1Oc NNP cord-004862-yv76yvy5 8 15 ) ) -RRB- cord-004862-yv76yvy5 8 16 has have VBZ cord-004862-yv76yvy5 8 17 been be VBN cord-004862-yv76yvy5 8 18 studied study VBN cord-004862-yv76yvy5 8 19 by by IN cord-004862-yv76yvy5 8 20 determining determine VBG cord-004862-yv76yvy5 8 21 the the DT cord-004862-yv76yvy5 8 22 sequence sequence NN cord-004862-yv76yvy5 8 23 of of IN cord-004862-yv76yvy5 8 24 the the DT cord-004862-yv76yvy5 8 25 five five CD cord-004862-yv76yvy5 8 26 L1 L1 NNP cord-004862-yv76yvy5 8 27 repeats repeat VBZ cord-004862-yv76yvy5 8 28 in in IN cord-004862-yv76yvy5 8 29 the the DT cord-004862-yv76yvy5 8 30 rabbit rabbit NN cord-004862-yv76yvy5 8 31 β β NN cord-004862-yv76yvy5 8 32 - - HYPH cord-004862-yv76yvy5 8 33 like like JJ cord-004862-yv76yvy5 8 34 globin globin NN cord-004862-yv76yvy5 8 35 gene gene NN cord-004862-yv76yvy5 8 36 cluster cluster NN cord-004862-yv76yvy5 8 37 and and CC cord-004862-yv76yvy5 8 38 by by IN cord-004862-yv76yvy5 8 39 hybridization hybridization NN cord-004862-yv76yvy5 8 40 analysis analysis NN cord-004862-yv76yvy5 8 41 of of IN cord-004862-yv76yvy5 8 42 other other JJ cord-004862-yv76yvy5 8 43 L1 L1 NNP cord-004862-yv76yvy5 8 44 repeats repeat VBZ cord-004862-yv76yvy5 8 45 in in IN cord-004862-yv76yvy5 8 46 the the DT cord-004862-yv76yvy5 8 47 genome genome NN cord-004862-yv76yvy5 8 48 . . . cord-004862-yv76yvy5 9 1 L1Oc l1oc PRP cord-004862-yv76yvy5 9 2 repeats repeat VBZ cord-004862-yv76yvy5 9 3 have have VBP cord-004862-yv76yvy5 9 4 a a DT cord-004862-yv76yvy5 9 5 common common JJ cord-004862-yv76yvy5 9 6 3′ 3′ CD cord-004862-yv76yvy5 9 7 end end NN cord-004862-yv76yvy5 9 8 that that WDT cord-004862-yv76yvy5 9 9 terminates terminate VBZ cord-004862-yv76yvy5 9 10 in in IN cord-004862-yv76yvy5 9 11 a a DT cord-004862-yv76yvy5 9 12 poly poly NN cord-004862-yv76yvy5 9 13 A A NNP cord-004862-yv76yvy5 9 14 addition addition NN cord-004862-yv76yvy5 9 15 signal signal NN cord-004862-yv76yvy5 9 16 and and CC cord-004862-yv76yvy5 9 17 an an DT cord-004862-yv76yvy5 9 18 A a NN cord-004862-yv76yvy5 9 19 - - HYPH cord-004862-yv76yvy5 9 20 rich rich JJ cord-004862-yv76yvy5 9 21 tract tract NN cord-004862-yv76yvy5 9 22 , , , cord-004862-yv76yvy5 9 23 but but CC cord-004862-yv76yvy5 9 24 individual individual NN cord-004862-yv76yvy5 9 25 repeats repeat NNS cord-004862-yv76yvy5 9 26 have have VBP cord-004862-yv76yvy5 9 27 different different JJ cord-004862-yv76yvy5 9 28 5′ 5′ CD cord-004862-yv76yvy5 9 29 ends end NNS cord-004862-yv76yvy5 9 30 , , , cord-004862-yv76yvy5 9 31 indicating indicate VBG cord-004862-yv76yvy5 9 32 a a DT cord-004862-yv76yvy5 9 33 polar polar JJ cord-004862-yv76yvy5 9 34 truncation truncation NN cord-004862-yv76yvy5 9 35 from from IN cord-004862-yv76yvy5 9 36 the the DT cord-004862-yv76yvy5 9 37 5′ 5′ CD cord-004862-yv76yvy5 9 38 end end NN cord-004862-yv76yvy5 9 39 during during IN cord-004862-yv76yvy5 9 40 their -PRON- PRP$ cord-004862-yv76yvy5 9 41 synthesis synthesis NN cord-004862-yv76yvy5 9 42 or or CC cord-004862-yv76yvy5 9 43 propagation propagation NN cord-004862-yv76yvy5 9 44 . . . cord-004862-yv76yvy5 10 1 As as IN cord-004862-yv76yvy5 10 2 a a DT cord-004862-yv76yvy5 10 3 result result NN cord-004862-yv76yvy5 10 4 of of IN cord-004862-yv76yvy5 10 5 the the DT cord-004862-yv76yvy5 10 6 polar polar JJ cord-004862-yv76yvy5 10 7 truncations truncation NNS cord-004862-yv76yvy5 10 8 , , , cord-004862-yv76yvy5 10 9 the the DT cord-004862-yv76yvy5 10 10 5′ 5′ CD cord-004862-yv76yvy5 10 11 end end NN cord-004862-yv76yvy5 10 12 of of IN cord-004862-yv76yvy5 10 13 L1Oc L1Oc NNP cord-004862-yv76yvy5 10 14 is be VBZ cord-004862-yv76yvy5 10 15 present present JJ cord-004862-yv76yvy5 10 16 in in IN cord-004862-yv76yvy5 10 17 about about RB cord-004862-yv76yvy5 10 18 11,000 11,000 CD cord-004862-yv76yvy5 10 19 copies copy NNS cord-004862-yv76yvy5 10 20 per per IN cord-004862-yv76yvy5 10 21 haploid haploid JJ cord-004862-yv76yvy5 10 22 genome genome NN cord-004862-yv76yvy5 10 23 , , , cord-004862-yv76yvy5 10 24 whereas whereas IN cord-004862-yv76yvy5 10 25 the the DT cord-004862-yv76yvy5 10 26 3′ 3′ CD cord-004862-yv76yvy5 10 27 end end NN cord-004862-yv76yvy5 10 28 is be VBZ cord-004862-yv76yvy5 10 29 present present JJ cord-004862-yv76yvy5 10 30 in in IN cord-004862-yv76yvy5 10 31 at at RB cord-004862-yv76yvy5 10 32 least least RBS cord-004862-yv76yvy5 10 33 66,000 66,000 CD cord-004862-yv76yvy5 10 34 copies copy NNS cord-004862-yv76yvy5 10 35 per per IN cord-004862-yv76yvy5 10 36 haploid haploid JJ cord-004862-yv76yvy5 10 37 genome genome NN cord-004862-yv76yvy5 10 38 . . . cord-004862-yv76yvy5 11 1 One one CD cord-004862-yv76yvy5 11 2 type type NN cord-004862-yv76yvy5 11 3 of of IN cord-004862-yv76yvy5 11 4 L1Oc L1Oc NNP cord-004862-yv76yvy5 11 5 repeat repeat NN cord-004862-yv76yvy5 11 6 has have VBZ cord-004862-yv76yvy5 11 7 internal internal JJ cord-004862-yv76yvy5 11 8 direct direct JJ cord-004862-yv76yvy5 11 9 repeats repeat NNS cord-004862-yv76yvy5 11 10 of of IN cord-004862-yv76yvy5 11 11 78 78 CD cord-004862-yv76yvy5 11 12 bp bp NNS cord-004862-yv76yvy5 11 13 in in IN cord-004862-yv76yvy5 11 14 the the DT cord-004862-yv76yvy5 11 15 3′ 3′ CD cord-004862-yv76yvy5 11 16 untranslated untranslated JJ cord-004862-yv76yvy5 11 17 region region NN cord-004862-yv76yvy5 11 18 , , , cord-004862-yv76yvy5 11 19 whereas whereas IN cord-004862-yv76yvy5 11 20 other other JJ cord-004862-yv76yvy5 11 21 L1Oc L1Oc NNP cord-004862-yv76yvy5 11 22 repeats repeat VBZ cord-004862-yv76yvy5 11 23 have have VBP cord-004862-yv76yvy5 11 24 only only RB cord-004862-yv76yvy5 11 25 one one CD cord-004862-yv76yvy5 11 26 copy copy NN cord-004862-yv76yvy5 11 27 of of IN cord-004862-yv76yvy5 11 28 this this DT cord-004862-yv76yvy5 11 29 sequence sequence NN cord-004862-yv76yvy5 11 30 . . . cord-004862-yv76yvy5 12 1 The the DT cord-004862-yv76yvy5 12 2 longest long JJS cord-004862-yv76yvy5 12 3 repeat repeat NN cord-004862-yv76yvy5 12 4 sequenced sequence VBN cord-004862-yv76yvy5 12 5 , , , cord-004862-yv76yvy5 12 6 L1Oc5 L1Oc5 NNP cord-004862-yv76yvy5 12 7 , , , cord-004862-yv76yvy5 12 8 is be VBZ cord-004862-yv76yvy5 12 9 6.5 6.5 CD cord-004862-yv76yvy5 12 10 kb kb NNP cord-004862-yv76yvy5 12 11 long long JJ cord-004862-yv76yvy5 12 12 , , , cord-004862-yv76yvy5 12 13 and and CC cord-004862-yv76yvy5 12 14 genomic genomic JJ cord-004862-yv76yvy5 12 15 blot blot NN cord-004862-yv76yvy5 12 16 - - HYPH cord-004862-yv76yvy5 12 17 hybridization hybridization NN cord-004862-yv76yvy5 12 18 data datum NNS cord-004862-yv76yvy5 12 19 using use VBG cord-004862-yv76yvy5 12 20 probes probe NNS cord-004862-yv76yvy5 12 21 from from IN cord-004862-yv76yvy5 12 22 the the DT cord-004862-yv76yvy5 12 23 5′ 5′ CD cord-004862-yv76yvy5 12 24 end end NN cord-004862-yv76yvy5 12 25 of of IN cord-004862-yv76yvy5 12 26 L1Oc5 L1Oc5 NNS cord-004862-yv76yvy5 12 27 indicate indicate VBP cord-004862-yv76yvy5 12 28 that that IN cord-004862-yv76yvy5 12 29 a a DT cord-004862-yv76yvy5 12 30 full full JJ cord-004862-yv76yvy5 12 31 length length NN cord-004862-yv76yvy5 12 32 L1Oc l1oc PRP cord-004862-yv76yvy5 12 33 repeat repeat NN cord-004862-yv76yvy5 12 34 is be VBZ cord-004862-yv76yvy5 12 35 about about RB cord-004862-yv76yvy5 12 36 7.5 7.5 CD cord-004862-yv76yvy5 12 37 kb kb NNP cord-004862-yv76yvy5 12 38 long long RB cord-004862-yv76yvy5 12 39 , , , cord-004862-yv76yvy5 12 40 extending extend VBG cord-004862-yv76yvy5 12 41 about about RB cord-004862-yv76yvy5 12 42 1 1 CD cord-004862-yv76yvy5 12 43 kb kb CD cord-004862-yv76yvy5 12 44 5′ 5′ CD cord-004862-yv76yvy5 12 45 to to IN cord-004862-yv76yvy5 12 46 the the DT cord-004862-yv76yvy5 12 47 sequenced sequence VBN cord-004862-yv76yvy5 12 48 region region NN cord-004862-yv76yvy5 12 49 . . . cord-004862-yv76yvy5 13 1 The the DT cord-004862-yv76yvy5 13 2 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 13 3 sequence sequence NN cord-004862-yv76yvy5 13 4 has have VBZ cord-004862-yv76yvy5 13 5 long long RB cord-004862-yv76yvy5 13 6 open open JJ cord-004862-yv76yvy5 13 7 reading reading NN cord-004862-yv76yvy5 13 8 frames frame NNS cord-004862-yv76yvy5 13 9 ( ( -LRB- cord-004862-yv76yvy5 13 10 ORFs ORFs NNP cord-004862-yv76yvy5 13 11 ) ) -RRB- cord-004862-yv76yvy5 13 12 that that WDT cord-004862-yv76yvy5 13 13 correspond correspond VBP cord-004862-yv76yvy5 13 14 to to IN cord-004862-yv76yvy5 13 15 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 13 16 and and CC cord-004862-yv76yvy5 13 17 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 13 18 described describe VBD cord-004862-yv76yvy5 13 19 in in IN cord-004862-yv76yvy5 13 20 the the DT cord-004862-yv76yvy5 13 21 mouse mouse NN cord-004862-yv76yvy5 13 22 L1 L1 NNP cord-004862-yv76yvy5 13 23 sequence sequence NN cord-004862-yv76yvy5 13 24 . . . cord-004862-yv76yvy5 14 1 In in IN cord-004862-yv76yvy5 14 2 contrast contrast NN cord-004862-yv76yvy5 14 3 to to IN cord-004862-yv76yvy5 14 4 the the DT cord-004862-yv76yvy5 14 5 overlapping overlap VBG cord-004862-yv76yvy5 14 6 reading reading NN cord-004862-yv76yvy5 14 7 frames frame NNS cord-004862-yv76yvy5 14 8 seen see VBN cord-004862-yv76yvy5 14 9 for for IN cord-004862-yv76yvy5 14 10 mouse mouse NN cord-004862-yv76yvy5 14 11 L1 L1 NNP cord-004862-yv76yvy5 14 12 , , , cord-004862-yv76yvy5 14 13 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 14 14 and and CC cord-004862-yv76yvy5 14 15 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 14 16 are be VBP cord-004862-yv76yvy5 14 17 in in IN cord-004862-yv76yvy5 14 18 the the DT cord-004862-yv76yvy5 14 19 same same JJ cord-004862-yv76yvy5 14 20 reading reading NN cord-004862-yv76yvy5 14 21 frame frame NN cord-004862-yv76yvy5 14 22 in in IN cord-004862-yv76yvy5 14 23 rabbit rabbit NN cord-004862-yv76yvy5 14 24 and and CC cord-004862-yv76yvy5 14 25 human human JJ cord-004862-yv76yvy5 14 26 L1s L1s NNP cord-004862-yv76yvy5 14 27 , , , cord-004862-yv76yvy5 14 28 resulting result VBG cord-004862-yv76yvy5 14 29 in in IN cord-004862-yv76yvy5 14 30 a a DT cord-004862-yv76yvy5 14 31 discistronic discistronic JJ cord-004862-yv76yvy5 14 32 structure structure NN cord-004862-yv76yvy5 14 33 . . . cord-004862-yv76yvy5 15 1 The the DT cord-004862-yv76yvy5 15 2 region region NN cord-004862-yv76yvy5 15 3 between between IN cord-004862-yv76yvy5 15 4 the the DT cord-004862-yv76yvy5 15 5 likely likely JJ cord-004862-yv76yvy5 15 6 stop stop NN cord-004862-yv76yvy5 15 7 codon codon NN cord-004862-yv76yvy5 15 8 for for IN cord-004862-yv76yvy5 15 9 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 15 10 and and CC cord-004862-yv76yvy5 15 11 the the DT cord-004862-yv76yvy5 15 12 proposed propose VBN cord-004862-yv76yvy5 15 13 start start NN cord-004862-yv76yvy5 15 14 codon codon NNP cord-004862-yv76yvy5 15 15 for for IN cord-004862-yv76yvy5 15 16 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 16 1 is be VBZ cord-004862-yv76yvy5 16 2 not not RB cord-004862-yv76yvy5 16 3 conserved conserve VBN cord-004862-yv76yvy5 16 4 in in IN cord-004862-yv76yvy5 16 5 interspecies interspecies JJ cord-004862-yv76yvy5 16 6 comparisons comparison NNS cord-004862-yv76yvy5 16 7 , , , cord-004862-yv76yvy5 16 8 which which WDT cord-004862-yv76yvy5 16 9 is be VBZ cord-004862-yv76yvy5 16 10 further further JJ cord-004862-yv76yvy5 16 11 evidence evidence NN cord-004862-yv76yvy5 16 12 that that IN cord-004862-yv76yvy5 16 13 this this DT cord-004862-yv76yvy5 16 14 short short JJ cord-004862-yv76yvy5 16 15 region region NN cord-004862-yv76yvy5 16 16 does do VBZ cord-004862-yv76yvy5 16 17 not not RB cord-004862-yv76yvy5 16 18 encode encode VB cord-004862-yv76yvy5 16 19 part part NN cord-004862-yv76yvy5 16 20 of of IN cord-004862-yv76yvy5 16 21 a a DT cord-004862-yv76yvy5 16 22 protein protein NN cord-004862-yv76yvy5 16 23 . . . cord-004862-yv76yvy5 17 1 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 17 2 appears appear VBZ cord-004862-yv76yvy5 17 3 to to TO cord-004862-yv76yvy5 17 4 be be VB cord-004862-yv76yvy5 17 5 a a DT cord-004862-yv76yvy5 17 6 hybrid hybrid NN cord-004862-yv76yvy5 17 7 of of IN cord-004862-yv76yvy5 17 8 sequences sequence NNS cord-004862-yv76yvy5 17 9 , , , cord-004862-yv76yvy5 17 10 of of IN cord-004862-yv76yvy5 17 11 which which WDT cord-004862-yv76yvy5 17 12 the the DT cord-004862-yv76yvy5 17 13 3′ 3′ CD cord-004862-yv76yvy5 17 14 half half NN cord-004862-yv76yvy5 17 15 is be VBZ cord-004862-yv76yvy5 17 16 unique unique JJ cord-004862-yv76yvy5 17 17 to to IN cord-004862-yv76yvy5 17 18 and and CC cord-004862-yv76yvy5 17 19 conserved conserve VBN cord-004862-yv76yvy5 17 20 in in IN cord-004862-yv76yvy5 17 21 mammalian mammalian JJ cord-004862-yv76yvy5 17 22 L1 L1 NNP cord-004862-yv76yvy5 17 23 repeats repeat VBZ cord-004862-yv76yvy5 17 24 . . . cord-004862-yv76yvy5 18 1 The the DT cord-004862-yv76yvy5 18 2 5′ 5′ CD cord-004862-yv76yvy5 18 3 half half NN cord-004862-yv76yvy5 18 4 of of IN cord-004862-yv76yvy5 18 5 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 18 6 is be VBZ cord-004862-yv76yvy5 18 7 not not RB cord-004862-yv76yvy5 18 8 conserved conserve VBN cord-004862-yv76yvy5 18 9 between between IN cord-004862-yv76yvy5 18 10 mammalian mammalian JJ cord-004862-yv76yvy5 18 11 L1 L1 NNP cord-004862-yv76yvy5 18 12 repeats repeat VBZ cord-004862-yv76yvy5 18 13 , , , cord-004862-yv76yvy5 18 14 but but CC cord-004862-yv76yvy5 18 15 this this DT cord-004862-yv76yvy5 18 16 segment segment NN cord-004862-yv76yvy5 18 17 of of IN cord-004862-yv76yvy5 18 18 L1Oc L1Oc NNP cord-004862-yv76yvy5 18 19 is be VBZ cord-004862-yv76yvy5 18 20 related relate VBN cord-004862-yv76yvy5 18 21 significantly significantly RB cord-004862-yv76yvy5 18 22 to to TO cord-004862-yv76yvy5 18 23 type type VB cord-004862-yv76yvy5 18 24 II II NNP cord-004862-yv76yvy5 18 25 cytoskeletal cytoskeletal JJ cord-004862-yv76yvy5 18 26 keratin keratin NN cord-004862-yv76yvy5 18 27 . . . cord-004862-yv76yvy5 19 1 The the DT cord-004862-yv76yvy5 19 2 repeated repeat VBN cord-004862-yv76yvy5 19 3 DNA dna NN cord-004862-yv76yvy5 19 4 sequences sequence NNS cord-004862-yv76yvy5 19 5 that that WDT cord-004862-yv76yvy5 19 6 are be VBP cord-004862-yv76yvy5 19 7 dispersed disperse VBN cord-004862-yv76yvy5 19 8 throughout throughout IN cord-004862-yv76yvy5 19 9 eukaryotic eukaryotic JJ cord-004862-yv76yvy5 19 10 genomes genome NNS cord-004862-yv76yvy5 19 11 have have VBP cord-004862-yv76yvy5 19 12 been be VBN cord-004862-yv76yvy5 19 13 divided divide VBN cord-004862-yv76yvy5 19 14 into into IN cord-004862-yv76yvy5 19 15 two two CD cord-004862-yv76yvy5 19 16 classes class NNS cord-004862-yv76yvy5 19 17 ( ( -LRB- cord-004862-yv76yvy5 19 18 reviewed review VBN cord-004862-yv76yvy5 19 19 by by IN cord-004862-yv76yvy5 19 20 Weiner Weiner NNP cord-004862-yv76yvy5 19 21 et et NNP cord-004862-yv76yvy5 19 22 al al NNP cord-004862-yv76yvy5 19 23 . . NNP cord-004862-yv76yvy5 19 24 1986 1986 CD cord-004862-yv76yvy5 19 25 ) ) -RRB- cord-004862-yv76yvy5 19 26 . . . cord-004862-yv76yvy5 20 1 Both both DT cord-004862-yv76yvy5 20 2 classes class NNS cord-004862-yv76yvy5 20 3 appear appear VBP cord-004862-yv76yvy5 20 4 to to TO cord-004862-yv76yvy5 20 5 transpose transpose VB cord-004862-yv76yvy5 20 6 by by IN cord-004862-yv76yvy5 20 7 an an DT cord-004862-yv76yvy5 20 8 RNA RNA NNP cord-004862-yv76yvy5 20 9 intermediate intermediate NN cord-004862-yv76yvy5 20 10 , , , cord-004862-yv76yvy5 20 11 and and CC cord-004862-yv76yvy5 20 12 the the DT cord-004862-yv76yvy5 20 13 insertion insertion NN cord-004862-yv76yvy5 20 14 of of IN cord-004862-yv76yvy5 20 15 either either DT cord-004862-yv76yvy5 20 16 class class NN cord-004862-yv76yvy5 20 17 of of IN cord-004862-yv76yvy5 20 18 repeated repeat VBN cord-004862-yv76yvy5 20 19 DNA dna NN cord-004862-yv76yvy5 20 20 generates generate VBZ cord-004862-yv76yvy5 20 21 short short JJ cord-004862-yv76yvy5 20 22 flanking flank VBG cord-004862-yv76yvy5 20 23 direct direct JJ cord-004862-yv76yvy5 20 24 repeats repeat NNS cord-004862-yv76yvy5 20 25 at at IN cord-004862-yv76yvy5 20 26 the the DT cord-004862-yv76yvy5 20 27 target target NN cord-004862-yv76yvy5 20 28 site site NN cord-004862-yv76yvy5 20 29 -- -- : cord-004862-yv76yvy5 20 30 hallmarks hallmark NNS cord-004862-yv76yvy5 20 31 of of IN cord-004862-yv76yvy5 20 32 transposition transposition NN cord-004862-yv76yvy5 20 33 first first RB cord-004862-yv76yvy5 20 34 recognized recognize VBN cord-004862-yv76yvy5 20 35 in in IN cord-004862-yv76yvy5 20 36 prokaryotes prokaryote NNS cord-004862-yv76yvy5 20 37 . . . cord-004862-yv76yvy5 21 1 One one CD cord-004862-yv76yvy5 21 2 class class NN cord-004862-yv76yvy5 21 3 of of IN cord-004862-yv76yvy5 21 4 repeated repeat VBN cord-004862-yv76yvy5 21 5 DNA dna NN cord-004862-yv76yvy5 21 6 resembles resemble VBZ cord-004862-yv76yvy5 21 7 retroviruses retrovirus NNS cord-004862-yv76yvy5 21 8 in in IN cord-004862-yv76yvy5 21 9 that that DT cord-004862-yv76yvy5 21 10 members member NNS cord-004862-yv76yvy5 21 11 of of IN cord-004862-yv76yvy5 21 12 this this DT cord-004862-yv76yvy5 21 13 class class NN cord-004862-yv76yvy5 21 14 are be VBP cord-004862-yv76yvy5 21 15 flanked flank VBN cord-004862-yv76yvy5 21 16 by by IN cord-004862-yv76yvy5 21 17 long long JJ cord-004862-yv76yvy5 21 18 terminal terminal NN cord-004862-yv76yvy5 21 19 repeats repeat NNS cord-004862-yv76yvy5 21 20 ( ( -LRB- cord-004862-yv76yvy5 21 21 Baltimore Baltimore NNP cord-004862-yv76yvy5 21 22 1985 1985 CD cord-004862-yv76yvy5 21 23 ) ) -RRB- cord-004862-yv76yvy5 21 24 . . . cord-004862-yv76yvy5 22 1 This this DT cord-004862-yv76yvy5 22 2 class class NN cord-004862-yv76yvy5 22 3 includes include VBZ cord-004862-yv76yvy5 22 4 the the DT cord-004862-yv76yvy5 22 5 yeast yeast NN cord-004862-yv76yvy5 22 6 Ty-1 Ty-1 NNP cord-004862-yv76yvy5 22 7 repeat repeat VBP cord-004862-yv76yvy5 22 8 , , , cord-004862-yv76yvy5 22 9 the the DT cord-004862-yv76yvy5 22 10 Drosophila Drosophila NNP cord-004862-yv76yvy5 22 11 copia copia NN cord-004862-yv76yvy5 22 12 repeat repeat NN cord-004862-yv76yvy5 22 13 , , , cord-004862-yv76yvy5 22 14 and and CC cord-004862-yv76yvy5 22 15 the the DT cord-004862-yv76yvy5 22 16 human human JJ cord-004862-yv76yvy5 22 17 THE1 THE1 NNP cord-004862-yv76yvy5 22 18 repeat repeat NN cord-004862-yv76yvy5 22 19 ( ( -LRB- cord-004862-yv76yvy5 22 20 Paulson Paulson NNP cord-004862-yv76yvy5 22 21 et et NNP cord-004862-yv76yvy5 22 22 al al NNP cord-004862-yv76yvy5 22 23 . . . cord-004862-yv76yvy5 22 24 1985 1985 CD cord-004862-yv76yvy5 22 25 ) ) -RRB- cord-004862-yv76yvy5 22 26 . . . cord-004862-yv76yvy5 23 1 Another another DT cord-004862-yv76yvy5 23 2 class class NN cord-004862-yv76yvy5 23 3 of of IN cord-004862-yv76yvy5 23 4 repeated repeat VBN cord-004862-yv76yvy5 23 5 sequences sequence NNS cord-004862-yv76yvy5 23 6 resembles resemble VBZ cord-004862-yv76yvy5 23 7 processed process VBN cord-004862-yv76yvy5 23 8 pseudogenes pseudogene NNS cord-004862-yv76yvy5 23 9 and and CC cord-004862-yv76yvy5 23 10 lacks lack VBZ cord-004862-yv76yvy5 23 11 long long JJ cord-004862-yv76yvy5 23 12 terminal terminal NN cord-004862-yv76yvy5 23 13 repeats repeat NNS cord-004862-yv76yvy5 23 14 ( ( -LRB- cord-004862-yv76yvy5 23 15 LTRs LTRs NNP cord-004862-yv76yvy5 23 16 ) ) -RRB- cord-004862-yv76yvy5 23 17 . . . cord-004862-yv76yvy5 24 1 This this DT cord-004862-yv76yvy5 24 2 second second JJ cord-004862-yv76yvy5 24 3 class class NN cord-004862-yv76yvy5 24 4 of of IN cord-004862-yv76yvy5 24 5 repeats repeat NNS cord-004862-yv76yvy5 24 6 has have VBZ cord-004862-yv76yvy5 24 7 been be VBN cord-004862-yv76yvy5 24 8 termed term VBN cord-004862-yv76yvy5 24 9 retroposons retroposon NNS cord-004862-yv76yvy5 24 10 ( ( -LRB- cord-004862-yv76yvy5 24 11 Rogers Rogers NNP cord-004862-yv76yvy5 24 12 1983 1983 CD cord-004862-yv76yvy5 24 13 ) ) -RRB- cord-004862-yv76yvy5 24 14 , , , cord-004862-yv76yvy5 24 15 nonviral nonviral JJ cord-004862-yv76yvy5 24 16 retroposons retroposon NNS cord-004862-yv76yvy5 24 17 ( ( -LRB- cord-004862-yv76yvy5 24 18 Weiner Weiner NNP cord-004862-yv76yvy5 24 19 et et NNP cord-004862-yv76yvy5 24 20 al al NNP cord-004862-yv76yvy5 24 21 . . NNP cord-004862-yv76yvy5 24 22 1986 1986 CD cord-004862-yv76yvy5 24 23 ) ) -RRB- cord-004862-yv76yvy5 24 24 , , , cord-004862-yv76yvy5 24 25 and and CC cord-004862-yv76yvy5 24 26 non non JJ cord-004862-yv76yvy5 24 27 - - JJ cord-004862-yv76yvy5 24 28 LTR ltr JJ cord-004862-yv76yvy5 24 29 retrotransposons retrotransposon NNS cord-004862-yv76yvy5 24 30 ( ( -LRB- cord-004862-yv76yvy5 24 31 Xiong Xiong NNP cord-004862-yv76yvy5 24 32 and and CC cord-004862-yv76yvy5 24 33 Eickbush Eickbush NNP cord-004862-yv76yvy5 24 34 1988 1988 CD cord-004862-yv76yvy5 24 35 ) ) -RRB- cord-004862-yv76yvy5 24 36 . . . cord-004862-yv76yvy5 25 1 In in IN cord-004862-yv76yvy5 25 2 this this DT cord-004862-yv76yvy5 25 3 paper paper NN cord-004862-yv76yvy5 25 4 , , , cord-004862-yv76yvy5 25 5 this this DT cord-004862-yv76yvy5 25 6 second second JJ cord-004862-yv76yvy5 25 7 class class NN cord-004862-yv76yvy5 25 8 of of IN cord-004862-yv76yvy5 25 9 RNAtransposed RNAtransposed NNP cord-004862-yv76yvy5 25 10 repeats repeat NNS cord-004862-yv76yvy5 25 11 will will MD cord-004862-yv76yvy5 25 12 be be VB cord-004862-yv76yvy5 25 13 called call VBN cord-004862-yv76yvy5 25 14 retroposons retroposon NNS cord-004862-yv76yvy5 25 15 . . . cord-004862-yv76yvy5 26 1 Two two CD cord-004862-yv76yvy5 26 2 groups group NNS cord-004862-yv76yvy5 26 3 of of IN cord-004862-yv76yvy5 26 4 retroposons retroposon NNS cord-004862-yv76yvy5 26 5 have have VBP cord-004862-yv76yvy5 26 6 been be VBN cord-004862-yv76yvy5 26 7 identified identify VBN cord-004862-yv76yvy5 26 8 based base VBN cord-004862-yv76yvy5 26 9 on on IN cord-004862-yv76yvy5 26 10 their -PRON- PRP$ cord-004862-yv76yvy5 26 11 length length NN cord-004862-yv76yvy5 26 12 : : : cord-004862-yv76yvy5 26 13 the the DT cord-004862-yv76yvy5 26 14 short short JJ cord-004862-yv76yvy5 26 15 interspersed intersperse VBN cord-004862-yv76yvy5 26 16 repeats repeat VBZ cord-004862-yv76yvy5 26 17 , , , cord-004862-yv76yvy5 26 18 or or CC cord-004862-yv76yvy5 26 19 SINEs sine NNS cord-004862-yv76yvy5 26 20 , , , cord-004862-yv76yvy5 26 21 that that WDT cord-004862-yv76yvy5 26 22 are be VBP cord-004862-yv76yvy5 26 23 tess tess NNP cord-004862-yv76yvy5 26 24 than than IN cord-004862-yv76yvy5 26 25 500 500 CD cord-004862-yv76yvy5 26 26 bp bp NNP cord-004862-yv76yvy5 26 27 long long NNP cord-004862-yv76yvy5 26 28 , , , cord-004862-yv76yvy5 26 29 and and CC cord-004862-yv76yvy5 26 30 the the DT cord-004862-yv76yvy5 26 31 long long JJ cord-004862-yv76yvy5 26 32 inter- inter- XX cord-004862-yv76yvy5 26 33 Repetitive repetitive JJ cord-004862-yv76yvy5 26 34 DNA dna NN cord-004862-yv76yvy5 26 35 in in IN cord-004862-yv76yvy5 26 36 the the DT cord-004862-yv76yvy5 26 37 rabbit/3-like rabbit/3-like JJ cord-004862-yv76yvy5 26 38 globin globin NN cord-004862-yv76yvy5 26 39 gene gene NN cord-004862-yv76yvy5 26 40 cluster cluster NN cord-004862-yv76yvy5 26 41 . . . cord-004862-yv76yvy5 27 1 The the DT cord-004862-yv76yvy5 27 2 0-like 0-like CD cord-004862-yv76yvy5 27 3 globin globin NN cord-004862-yv76yvy5 27 4 genes gene NNS cord-004862-yv76yvy5 27 5 ~ ~ NFP cord-004862-yv76yvy5 27 6 , , , cord-004862-yv76yvy5 27 7 7 7 CD cord-004862-yv76yvy5 27 8 , , , cord-004862-yv76yvy5 27 9 6 6 CD cord-004862-yv76yvy5 27 10 , , , cord-004862-yv76yvy5 27 11 and/3 and/3 NNP cord-004862-yv76yvy5 27 12 are be VBP cord-004862-yv76yvy5 27 13 shown show VBN cord-004862-yv76yvy5 27 14 as as IN cord-004862-yv76yvy5 27 15 boxes box NNS cord-004862-yv76yvy5 27 16 along along IN cord-004862-yv76yvy5 27 17 the the DT cord-004862-yv76yvy5 27 18 45-kb 45-kb CD cord-004862-yv76yvy5 27 19 segment segment NN cord-004862-yv76yvy5 27 20 of of IN cord-004862-yv76yvy5 27 21 cloned clone VBN cord-004862-yv76yvy5 27 22 DNA dna NN cord-004862-yv76yvy5 27 23 ( ( -LRB- cord-004862-yv76yvy5 27 24 Lacy Lacy NNP cord-004862-yv76yvy5 27 25 et et FW cord-004862-yv76yvy5 27 26 al al NNP cord-004862-yv76yvy5 27 27 . . . cord-004862-yv76yvy5 27 28 1979 1979 CD cord-004862-yv76yvy5 27 29 ) ) -RRB- cord-004862-yv76yvy5 27 30 . . . cord-004862-yv76yvy5 28 1 Transcription transcription NN cord-004862-yv76yvy5 28 2 of of IN cord-004862-yv76yvy5 28 3 the the DT cord-004862-yv76yvy5 28 4 active active JJ cord-004862-yv76yvy5 28 5 genes gene NNS cord-004862-yv76yvy5 28 6 is be VBZ cord-004862-yv76yvy5 28 7 from from IN cord-004862-yv76yvy5 28 8 left leave VBN cord-004862-yv76yvy5 28 9 to to IN cord-004862-yv76yvy5 28 10 right right NN cord-004862-yv76yvy5 28 11 . . . cord-004862-yv76yvy5 29 1 The the DT cord-004862-yv76yvy5 29 2 location location NN cord-004862-yv76yvy5 29 3 and and CC cord-004862-yv76yvy5 29 4 orientation orientation NN cord-004862-yv76yvy5 29 5 of of IN cord-004862-yv76yvy5 29 6 L1 L1 NNP cord-004862-yv76yvy5 29 7 repeats repeat NNS cord-004862-yv76yvy5 29 8 are be VBP cord-004862-yv76yvy5 29 9 shown show VBN cord-004862-yv76yvy5 29 10 by by IN cord-004862-yv76yvy5 29 11 the the DT cord-004862-yv76yvy5 29 12 filled fill VBN cord-004862-yv76yvy5 29 13 arrows arrow NNS cord-004862-yv76yvy5 29 14 . . . cord-004862-yv76yvy5 30 1 The the DT cord-004862-yv76yvy5 30 2 L1 L1 NNP cord-004862-yv76yvy5 30 3 repeats repeat NNS cord-004862-yv76yvy5 30 4 are be VBP cord-004862-yv76yvy5 30 5 named name VBN cord-004862-yv76yvy5 30 6 LIOcl LIOcl NNP cord-004862-yv76yvy5 30 7 - - HYPH cord-004862-yv76yvy5 30 8 L1Oc5 L1Oc5 NNP cord-004862-yv76yvy5 30 9 ( ( -LRB- cord-004862-yv76yvy5 30 10 Demers Demers NNP cord-004862-yv76yvy5 30 11 et et FW cord-004862-yv76yvy5 30 12 al al NNP cord-004862-yv76yvy5 30 13 . . NNP cord-004862-yv76yvy5 30 14 1986 1986 CD cord-004862-yv76yvy5 30 15 ) ) -RRB- cord-004862-yv76yvy5 30 16 . . . cord-004862-yv76yvy5 31 1 The the DT cord-004862-yv76yvy5 31 2 location location NN cord-004862-yv76yvy5 31 3 and and CC cord-004862-yv76yvy5 31 4 orientation orientation NN cord-004862-yv76yvy5 31 5 of of IN cord-004862-yv76yvy5 31 6 C C NNP cord-004862-yv76yvy5 31 7 repeats repeat VBZ cord-004862-yv76yvy5 31 8 , , , cord-004862-yv76yvy5 31 9 a a DT cord-004862-yv76yvy5 31 10 rabbit rabbit NN cord-004862-yv76yvy5 31 11 SINE sine NN cord-004862-yv76yvy5 31 12 , , , cord-004862-yv76yvy5 31 13 are be VBP cord-004862-yv76yvy5 31 14 shown show VBN cord-004862-yv76yvy5 31 15 by by IN cord-004862-yv76yvy5 31 16 the the DT cord-004862-yv76yvy5 31 17 open open JJ cord-004862-yv76yvy5 31 18 arrows arrow NNS cord-004862-yv76yvy5 31 19 . . . cord-004862-yv76yvy5 32 1 spersed spersed NNP cord-004862-yv76yvy5 32 2 repeats repeat VBZ cord-004862-yv76yvy5 32 3 , , , cord-004862-yv76yvy5 32 4 or or CC cord-004862-yv76yvy5 32 5 LINEs line NNS cord-004862-yv76yvy5 32 6 , , , cord-004862-yv76yvy5 33 1 that that WDT cord-004862-yv76yvy5 33 2 are be VBP cord-004862-yv76yvy5 33 3 greater great JJR cord-004862-yv76yvy5 33 4 than than IN cord-004862-yv76yvy5 33 5 6000 6000 CD cord-004862-yv76yvy5 33 6 bp bp NNP cord-004862-yv76yvy5 33 7 long long NNP cord-004862-yv76yvy5 33 8 ( ( -LRB- cord-004862-yv76yvy5 33 9 Singer singer NN cord-004862-yv76yvy5 33 10 1982 1982 CD cord-004862-yv76yvy5 33 11 ) ) -RRB- cord-004862-yv76yvy5 33 12 . . . cord-004862-yv76yvy5 34 1 Although although IN cord-004862-yv76yvy5 34 2 no no DT cord-004862-yv76yvy5 34 3 precise precise JJ cord-004862-yv76yvy5 34 4 sequence sequence NN cord-004862-yv76yvy5 34 5 specificity specificity NN cord-004862-yv76yvy5 34 6 has have VBZ cord-004862-yv76yvy5 34 7 been be VBN cord-004862-yv76yvy5 34 8 observed observe VBN cord-004862-yv76yvy5 34 9 at at IN cord-004862-yv76yvy5 34 10 the the DT cord-004862-yv76yvy5 34 11 insertion insertion NN cord-004862-yv76yvy5 34 12 sites site NNS cord-004862-yv76yvy5 34 13 , , , cord-004862-yv76yvy5 34 14 SINEs sine NNS cord-004862-yv76yvy5 34 15 and and CC cord-004862-yv76yvy5 34 16 LINEs line NNS cord-004862-yv76yvy5 34 17 do do VBP cord-004862-yv76yvy5 34 18 have have VB cord-004862-yv76yvy5 34 19 a a DT cord-004862-yv76yvy5 34 20 regional regional JJ cord-004862-yv76yvy5 34 21 preference preference NN cord-004862-yv76yvy5 34 22 for for IN cord-004862-yv76yvy5 34 23 integration integration NN cord-004862-yv76yvy5 34 24 in in IN cord-004862-yv76yvy5 34 25 the the DT cord-004862-yv76yvy5 34 26 human human JJ cord-004862-yv76yvy5 34 27 genome genome NN cord-004862-yv76yvy5 34 28 , , , cord-004862-yv76yvy5 34 29 as as IN cord-004862-yv76yvy5 34 30 shown show VBN cord-004862-yv76yvy5 34 31 by by IN cord-004862-yv76yvy5 34 32 the the DT cord-004862-yv76yvy5 34 33 enrichment enrichment NN cord-004862-yv76yvy5 34 34 of of IN cord-004862-yv76yvy5 34 35 different different JJ cord-004862-yv76yvy5 34 36 chromosome chromosome NN cord-004862-yv76yvy5 34 37 bands band NNS cord-004862-yv76yvy5 34 38 for for IN cord-004862-yv76yvy5 34 39 either either CC cord-004862-yv76yvy5 34 40 LINEs line NNS cord-004862-yv76yvy5 34 41 or or CC cord-004862-yv76yvy5 34 42 SINEs sine NNS cord-004862-yv76yvy5 34 43 ( ( -LRB- cord-004862-yv76yvy5 34 44 Korenberg Korenberg NNP cord-004862-yv76yvy5 34 45 and and CC cord-004862-yv76yvy5 34 46 Rykowski Rykowski NNP cord-004862-yv76yvy5 34 47 1988 1988 CD cord-004862-yv76yvy5 34 48 ) ) -RRB- cord-004862-yv76yvy5 34 49 . . . cord-004862-yv76yvy5 35 1 Although although IN cord-004862-yv76yvy5 35 2 several several JJ cord-004862-yv76yvy5 35 3 different different JJ cord-004862-yv76yvy5 35 4 sequences sequence NNS cord-004862-yv76yvy5 35 5 have have VBP cord-004862-yv76yvy5 35 6 been be VBN cord-004862-yv76yvy5 35 7 dispersed disperse VBN cord-004862-yv76yvy5 35 8 as as IN cord-004862-yv76yvy5 35 9 SINEs sine NNS cord-004862-yv76yvy5 35 10 in in IN cord-004862-yv76yvy5 35 11 mammals mammal NNS cord-004862-yv76yvy5 35 12 ( ( -LRB- cord-004862-yv76yvy5 35 13 reviewed review VBN cord-004862-yv76yvy5 35 14 in in IN cord-004862-yv76yvy5 35 15 Weiner Weiner NNP cord-004862-yv76yvy5 35 16 et et NNP cord-004862-yv76yvy5 35 17 al al NNP cord-004862-yv76yvy5 35 18 . . NNP cord-004862-yv76yvy5 35 19 1986 1986 CD cord-004862-yv76yvy5 35 20 ) ) -RRB- cord-004862-yv76yvy5 35 21 , , , cord-004862-yv76yvy5 35 22 only only RB cord-004862-yv76yvy5 35 23 one one CD cord-004862-yv76yvy5 35 24 sequence sequence NN cord-004862-yv76yvy5 35 25 element element NN cord-004862-yv76yvy5 35 26 , , , cord-004862-yv76yvy5 35 27 called call VBN cord-004862-yv76yvy5 35 28 L1 L1 NNP cord-004862-yv76yvy5 35 29 , , , cord-004862-yv76yvy5 35 30 has have VBZ cord-004862-yv76yvy5 35 31 been be VBN cord-004862-yv76yvy5 35 32 found find VBN cord-004862-yv76yvy5 35 33 to to TO cord-004862-yv76yvy5 35 34 be be VB cord-004862-yv76yvy5 35 35 dispersed disperse VBN cord-004862-yv76yvy5 35 36 as as IN cord-004862-yv76yvy5 35 37 a a DT cord-004862-yv76yvy5 35 38 LINE line NN cord-004862-yv76yvy5 35 39 in in IN cord-004862-yv76yvy5 35 40 mammals mammal NNS cord-004862-yv76yvy5 35 41 ( ( -LRB- cord-004862-yv76yvy5 35 42 reviewed review VBN cord-004862-yv76yvy5 35 43 in in IN cord-004862-yv76yvy5 35 44 Singer Singer NNP cord-004862-yv76yvy5 35 45 and and CC cord-004862-yv76yvy5 35 46 Skowronski Skowronski NNP cord-004862-yv76yvy5 35 47 1985 1985 CD cord-004862-yv76yvy5 35 48 ) ) -RRB- cord-004862-yv76yvy5 35 49 . . . cord-004862-yv76yvy5 36 1 The the DT cord-004862-yv76yvy5 36 2 L1 L1 NNP cord-004862-yv76yvy5 36 3 sequence sequence NN cord-004862-yv76yvy5 36 4 has have VBZ cord-004862-yv76yvy5 36 5 been be VBN cord-004862-yv76yvy5 36 6 identified identify VBN cord-004862-yv76yvy5 36 7 in in IN cord-004862-yv76yvy5 36 8 a a DT cord-004862-yv76yvy5 36 9 wide wide JJ cord-004862-yv76yvy5 36 10 variety variety NN cord-004862-yv76yvy5 36 11 of of IN cord-004862-yv76yvy5 36 12 species specie NNS cord-004862-yv76yvy5 36 13 including include VBG cord-004862-yv76yvy5 36 14 primates primate NNS cord-004862-yv76yvy5 36 15 ( ( -LRB- cord-004862-yv76yvy5 36 16 Lerman Lerman NNP cord-004862-yv76yvy5 36 17 et et NNP cord-004862-yv76yvy5 36 18 al al NNP cord-004862-yv76yvy5 36 19 . . . cord-004862-yv76yvy5 36 20 1983 1983 CD cord-004862-yv76yvy5 36 21 ) ) -RRB- cord-004862-yv76yvy5 36 22 , , , cord-004862-yv76yvy5 36 23 mice mouse NNS cord-004862-yv76yvy5 36 24 ( ( -LRB- cord-004862-yv76yvy5 36 25 Brown Brown NNP cord-004862-yv76yvy5 36 26 and and CC cord-004862-yv76yvy5 36 27 Dover Dover NNP cord-004862-yv76yvy5 36 28 1981 1981 CD cord-004862-yv76yvy5 36 29 ; ; : cord-004862-yv76yvy5 36 30 Fanning Fanning NNP cord-004862-yv76yvy5 36 31 1982 1982 CD cord-004862-yv76yvy5 36 32 ) ) -RRB- cord-004862-yv76yvy5 36 33 , , , cord-004862-yv76yvy5 36 34 rats rat NNS cord-004862-yv76yvy5 36 35 ( ( -LRB- cord-004862-yv76yvy5 36 36 Econonmou Econonmou NNP cord-004862-yv76yvy5 36 37 - - HYPH cord-004862-yv76yvy5 36 38 Pachnis Pachnis NNP cord-004862-yv76yvy5 36 39 et et NNP cord-004862-yv76yvy5 36 40 al al NNP cord-004862-yv76yvy5 36 41 . . . cord-004862-yv76yvy5 36 42 1985 1985 CD cord-004862-yv76yvy5 36 43 ; ; : cord-004862-yv76yvy5 36 44 Soares Soares NNP cord-004862-yv76yvy5 36 45 et et NNP cord-004862-yv76yvy5 36 46 al al NNP cord-004862-yv76yvy5 36 47 . . . cord-004862-yv76yvy5 37 1 1985 1985 CD cord-004862-yv76yvy5 37 2 ; ; : cord-004862-yv76yvy5 37 3 D'Ambrosio D'Ambrosio NNP cord-004862-yv76yvy5 37 4 et et NNP cord-004862-yv76yvy5 37 5 al al NNP cord-004862-yv76yvy5 37 6 . . NNP cord-004862-yv76yvy5 37 7 1986 1986 CD cord-004862-yv76yvy5 37 8 ) ) -RRB- cord-004862-yv76yvy5 37 9 , , , cord-004862-yv76yvy5 37 10 dogs dog NNS cord-004862-yv76yvy5 37 11 ( ( -LRB- cord-004862-yv76yvy5 37 12 Katzir Katzir NNP cord-004862-yv76yvy5 37 13 et et FW cord-004862-yv76yvy5 37 14 al al NNP cord-004862-yv76yvy5 37 15 . . . cord-004862-yv76yvy5 37 16 1985 1985 CD cord-004862-yv76yvy5 37 17 ) ) -RRB- cord-004862-yv76yvy5 37 18 , , , cord-004862-yv76yvy5 37 19 eats eat VBZ cord-004862-yv76yvy5 37 20 ( ( -LRB- cord-004862-yv76yvy5 37 21 Fanning Fanning NNP cord-004862-yv76yvy5 37 22 and and CC cord-004862-yv76yvy5 37 23 Singer Singer NNP cord-004862-yv76yvy5 37 24 1987 1987 CD cord-004862-yv76yvy5 37 25 ) ) -RRB- cord-004862-yv76yvy5 37 26 , , , cord-004862-yv76yvy5 37 27 and and CC cord-004862-yv76yvy5 37 28 rabbits rabbit NNS cord-004862-yv76yvy5 37 29 ( ( -LRB- cord-004862-yv76yvy5 37 30 Demers Demers NNP cord-004862-yv76yvy5 37 31 et et FW cord-004862-yv76yvy5 37 32 al al NNP cord-004862-yv76yvy5 37 33 . . NNP cord-004862-yv76yvy5 37 34 1986 1986 CD cord-004862-yv76yvy5 37 35 ) ) -RRB- cord-004862-yv76yvy5 37 36 . . . cord-004862-yv76yvy5 38 1 Genomic genomic JJ cord-004862-yv76yvy5 38 2 blot blot NN cord-004862-yv76yvy5 38 3 - - HYPH cord-004862-yv76yvy5 38 4 hybridization hybridization NN cord-004862-yv76yvy5 38 5 analysis analysis NN cord-004862-yv76yvy5 38 6 indicates indicate VBZ cord-004862-yv76yvy5 38 7 that that IN cord-004862-yv76yvy5 38 8 the the DT cord-004862-yv76yvy5 38 9 L1 L1 NNP cord-004862-yv76yvy5 38 10 sequence sequence NN cord-004862-yv76yvy5 38 11 is be VBZ cord-004862-yv76yvy5 38 12 present present JJ cord-004862-yv76yvy5 38 13 in in IN cord-004862-yv76yvy5 38 14 all all DT cord-004862-yv76yvy5 38 15 mammalian mammalian JJ cord-004862-yv76yvy5 38 16 species specie NNS cord-004862-yv76yvy5 38 17 at at IN cord-004862-yv76yvy5 38 18 a a DT cord-004862-yv76yvy5 38 19 frequency frequency NN cord-004862-yv76yvy5 38 20 of of IN cord-004862-yv76yvy5 38 21 about about IN cord-004862-yv76yvy5 38 22 104 104 CD cord-004862-yv76yvy5 38 23 - - SYM cord-004862-yv76yvy5 38 24 105 105 CD cord-004862-yv76yvy5 38 25 copies copy NNS cord-004862-yv76yvy5 38 26 per per IN cord-004862-yv76yvy5 38 27 haploid haploid JJ cord-004862-yv76yvy5 38 28 genome genome NN cord-004862-yv76yvy5 38 29 ( ( -LRB- cord-004862-yv76yvy5 38 30 Burton Burton NNP cord-004862-yv76yvy5 38 31 et et NNP cord-004862-yv76yvy5 38 32 al al NNP cord-004862-yv76yvy5 38 33 . . NNP cord-004862-yv76yvy5 38 34 1986 1986 CD cord-004862-yv76yvy5 38 35 ) ) -RRB- cord-004862-yv76yvy5 38 36 . . . cord-004862-yv76yvy5 39 1 Although although IN cord-004862-yv76yvy5 39 2 the the DT cord-004862-yv76yvy5 39 3 parent parent NN cord-004862-yv76yvy5 39 4 genes gene NNS cord-004862-yv76yvy5 39 5 of of IN cord-004862-yv76yvy5 39 6 SINEs sine NNS cord-004862-yv76yvy5 39 7 are be VBP cord-004862-yv76yvy5 39 8 transcribed transcribe VBN cord-004862-yv76yvy5 39 9 by by IN cord-004862-yv76yvy5 39 10 RNA RNA NNP cord-004862-yv76yvy5 39 11 polymerase polymerase NN cord-004862-yv76yvy5 39 12 III III NNP cord-004862-yv76yvy5 39 13 , , , cord-004862-yv76yvy5 39 14 the the DT cord-004862-yv76yvy5 39 15 L1 L1 NNP cord-004862-yv76yvy5 39 16 repeats repeat VBZ cord-004862-yv76yvy5 39 17 appear appear VBP cord-004862-yv76yvy5 39 18 to to TO cord-004862-yv76yvy5 39 19 be be VB cord-004862-yv76yvy5 39 20 derived derive VBN cord-004862-yv76yvy5 39 21 from from IN cord-004862-yv76yvy5 39 22 an an DT cord-004862-yv76yvy5 39 23 RNA RNA NNP cord-004862-yv76yvy5 39 24 polymerase polymerase NN cord-004862-yv76yvy5 39 25 II II NNP cord-004862-yv76yvy5 39 26 transcript transcript NN cord-004862-yv76yvy5 39 27 . . . cord-004862-yv76yvy5 40 1 The the DT cord-004862-yv76yvy5 40 2 parent parent NN cord-004862-yv76yvy5 40 3 gene gene NN cord-004862-yv76yvy5 40 4 of of IN cord-004862-yv76yvy5 40 5 L1 L1 NNP cord-004862-yv76yvy5 40 6 is be VBZ cord-004862-yv76yvy5 40 7 proposed propose VBN cord-004862-yv76yvy5 40 8 to to TO cord-004862-yv76yvy5 40 9 be be VB cord-004862-yv76yvy5 40 10 a a DT cord-004862-yv76yvy5 40 11 protein protein NN cord-004862-yv76yvy5 40 12 - - HYPH cord-004862-yv76yvy5 40 13 coding code VBG cord-004862-yv76yvy5 40 14 gene gene NN cord-004862-yv76yvy5 40 15 ( ( -LRB- cord-004862-yv76yvy5 40 16 reviewed review VBN cord-004862-yv76yvy5 40 17 in in IN cord-004862-yv76yvy5 40 18 Singer Singer NNP cord-004862-yv76yvy5 40 19 and and CC cord-004862-yv76yvy5 40 20 Skowronski Skowronski NNP cord-004862-yv76yvy5 40 21 1985 1985 CD cord-004862-yv76yvy5 40 22 ) ) -RRB- cord-004862-yv76yvy5 40 23 . . . cord-004862-yv76yvy5 41 1 Long long RB cord-004862-yv76yvy5 41 2 open open JJ cord-004862-yv76yvy5 41 3 reading reading NN cord-004862-yv76yvy5 41 4 frames frame NNS cord-004862-yv76yvy5 41 5 ( ( -LRB- cord-004862-yv76yvy5 41 6 ORFs ORFs NNP cord-004862-yv76yvy5 41 7 ) ) -RRB- cord-004862-yv76yvy5 41 8 are be VBP cord-004862-yv76yvy5 41 9 found find VBN cord-004862-yv76yvy5 41 10 in in IN cord-004862-yv76yvy5 41 11 the the DT cord-004862-yv76yvy5 41 12 L1 L1 NNP cord-004862-yv76yvy5 41 13 sequences sequence NNS cord-004862-yv76yvy5 41 14 ( ( -LRB- cord-004862-yv76yvy5 41 15 Manuelidis Manuelidis NNP cord-004862-yv76yvy5 41 16 1982 1982 CD cord-004862-yv76yvy5 41 17 ; ; : cord-004862-yv76yvy5 41 18 Martin Martin NNP cord-004862-yv76yvy5 41 19 et et NNP cord-004862-yv76yvy5 41 20 al al NNP cord-004862-yv76yvy5 41 21 . . . cord-004862-yv76yvy5 41 22 1984 1984 CD cord-004862-yv76yvy5 41 23 ; ; : cord-004862-yv76yvy5 41 24 Potter Potter NNP cord-004862-yv76yvy5 41 25 1984 1984 CD cord-004862-yv76yvy5 41 26 ) ) -RRB- cord-004862-yv76yvy5 41 27 , , , cord-004862-yv76yvy5 41 28 and and CC cord-004862-yv76yvy5 41 29 sequenced sequence VBN cord-004862-yv76yvy5 41 30 members member NNS cord-004862-yv76yvy5 41 31 from from IN cord-004862-yv76yvy5 41 32 the the DT cord-004862-yv76yvy5 41 33 mouse mouse NN cord-004862-yv76yvy5 41 34 genome genome NN cord-004862-yv76yvy5 41 35 have have VBP cord-004862-yv76yvy5 41 36 two two CD cord-004862-yv76yvy5 41 37 overlapping overlap VBG cord-004862-yv76yvy5 41 38 ORFs orf NNS cord-004862-yv76yvy5 41 39 of of IN cord-004862-yv76yvy5 41 40 1137 1137 CD cord-004862-yv76yvy5 41 41 bp bp NNP cord-004862-yv76yvy5 41 42 ( ( -LRB- cord-004862-yv76yvy5 41 43 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 41 44 ) ) -RRB- cord-004862-yv76yvy5 41 45 and and CC cord-004862-yv76yvy5 41 46 3900 3900 CD cord-004862-yv76yvy5 41 47 bp bp NNP cord-004862-yv76yvy5 41 48 ( ( -LRB- cord-004862-yv76yvy5 41 49 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 41 50 ) ) -RRB- cord-004862-yv76yvy5 42 1 Shehee Shehee NNP cord-004862-yv76yvy5 42 2 et et NNP cord-004862-yv76yvy5 42 3 al al NNP cord-004862-yv76yvy5 42 4 . . NNP cord-004862-yv76yvy5 42 5 1987 1987 CD cord-004862-yv76yvy5 42 6 ) ) -RRB- cord-004862-yv76yvy5 42 7 . . . cord-004862-yv76yvy5 43 1 The the DT cord-004862-yv76yvy5 43 2 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 43 3 regions region NNS cord-004862-yv76yvy5 43 4 of of IN cord-004862-yv76yvy5 43 5 primate primate NN cord-004862-yv76yvy5 43 6 and and CC cord-004862-yv76yvy5 43 7 rabbit rabbit NN cord-004862-yv76yvy5 43 8 LI LI NNP cord-004862-yv76yvy5 43 9 are be VBP cord-004862-yv76yvy5 43 10 65 65 CD cord-004862-yv76yvy5 43 11 % % NN cord-004862-yv76yvy5 43 12 similar similar JJ cord-004862-yv76yvy5 43 13 , , , cord-004862-yv76yvy5 43 14 but but CC cord-004862-yv76yvy5 43 15 the the DT cord-004862-yv76yvy5 43 16 similarity similarity NN cord-004862-yv76yvy5 43 17 ends end VBZ cord-004862-yv76yvy5 43 18 abruptly abruptly RB cord-004862-yv76yvy5 43 19 at at IN cord-004862-yv76yvy5 43 20 a a DT cord-004862-yv76yvy5 43 21 conserved conserved JJ cord-004862-yv76yvy5 43 22 stop stop NN cord-004862-yv76yvy5 43 23 codon codon NN cord-004862-yv76yvy5 43 24 ( ( -LRB- cord-004862-yv76yvy5 43 25 Demers Demers NNP cord-004862-yv76yvy5 43 26 et et FW cord-004862-yv76yvy5 43 27 al al NNP cord-004862-yv76yvy5 43 28 . . NNP cord-004862-yv76yvy5 43 29 1986 1986 CD cord-004862-yv76yvy5 43 30 ) ) -RRB- cord-004862-yv76yvy5 43 31 . . . cord-004862-yv76yvy5 44 1 In in IN cord-004862-yv76yvy5 44 2 previous previous JJ cord-004862-yv76yvy5 44 3 studies study NNS cord-004862-yv76yvy5 44 4 on on IN cord-004862-yv76yvy5 44 5 the the DT cord-004862-yv76yvy5 44 6 L l NN cord-004862-yv76yvy5 44 7 1 1 CD cord-004862-yv76yvy5 44 8 repeats repeat VBZ cord-004862-yv76yvy5 44 9 from from IN cord-004862-yv76yvy5 44 10 rabbits rabbit NNS cord-004862-yv76yvy5 44 11 ( ( -LRB- cord-004862-yv76yvy5 44 12 L L NNP cord-004862-yv76yvy5 44 13 10c 10c NNP cord-004862-yv76yvy5 44 14 , , , cord-004862-yv76yvy5 44 15 for for IN cord-004862-yv76yvy5 44 16 LINE line NN cord-004862-yv76yvy5 44 17 1 1 CD cord-004862-yv76yvy5 44 18 from from IN cord-004862-yv76yvy5 44 19 Oryctolagus Oryctolagus NNP cord-004862-yv76yvy5 44 20 cuniculus cuniculus NNP cord-004862-yv76yvy5 44 21 ) ) -RRB- cord-004862-yv76yvy5 44 22 , , , cord-004862-yv76yvy5 44 23 the the DT cord-004862-yv76yvy5 44 24 B b NN cord-004862-yv76yvy5 44 25 , , , cord-004862-yv76yvy5 44 26 E E NNP cord-004862-yv76yvy5 44 27 , , , cord-004862-yv76yvy5 44 28 and and CC cord-004862-yv76yvy5 44 29 D D NNP cord-004862-yv76yvy5 44 30 repeats repeat NNS cord-004862-yv76yvy5 44 31 identified identify VBN cord-004862-yv76yvy5 44 32 by by IN cord-004862-yv76yvy5 44 33 Shen Shen NNP cord-004862-yv76yvy5 44 34 and and CC cord-004862-yv76yvy5 44 35 Maniatis Maniatis NNP cord-004862-yv76yvy5 44 36 ( ( -LRB- cord-004862-yv76yvy5 44 37 1980 1980 CD cord-004862-yv76yvy5 44 38 ) ) -RRB- cord-004862-yv76yvy5 44 39 were be VBD cord-004862-yv76yvy5 44 40 shown show VBN cord-004862-yv76yvy5 44 41 to to TO cord-004862-yv76yvy5 44 42 be be VB cord-004862-yv76yvy5 44 43 parts part NNS cord-004862-yv76yvy5 44 44 of of IN cord-004862-yv76yvy5 44 45 the the DT cord-004862-yv76yvy5 44 46 L1Oc L1Oc NNP cord-004862-yv76yvy5 44 47 repeat repeat NN cord-004862-yv76yvy5 44 48 . . . cord-004862-yv76yvy5 45 1 The the DT cord-004862-yv76yvy5 45 2 sequence sequence NN cord-004862-yv76yvy5 45 3 of of IN cord-004862-yv76yvy5 45 4 one one CD cord-004862-yv76yvy5 45 5 truncated truncated JJ cord-004862-yv76yvy5 45 6 L1 L1 NNP cord-004862-yv76yvy5 45 7 repeat repeat NN cord-004862-yv76yvy5 45 8 and and CC cord-004862-yv76yvy5 45 9 part part NN cord-004862-yv76yvy5 45 10 of of IN cord-004862-yv76yvy5 45 11 another another DT cord-004862-yv76yvy5 45 12 repeat repeat NN cord-004862-yv76yvy5 45 13 were be VBD cord-004862-yv76yvy5 45 14 presented present VBN cord-004862-yv76yvy5 45 15 as as IN cord-004862-yv76yvy5 45 16 a a DT cord-004862-yv76yvy5 45 17 composite composite JJ cord-004862-yv76yvy5 45 18 sequence sequence NN cord-004862-yv76yvy5 45 19 , , , cord-004862-yv76yvy5 45 20 and and CC cord-004862-yv76yvy5 45 21 the the DT cord-004862-yv76yvy5 45 22 ORF ORF NNP cord-004862-yv76yvy5 45 23 ( ( -LRB- cord-004862-yv76yvy5 45 24 corresponding correspond VBG cord-004862-yv76yvy5 45 25 to to IN cord-004862-yv76yvy5 45 26 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 45 27 ) ) -RRB- cord-004862-yv76yvy5 45 28 and and CC cord-004862-yv76yvy5 45 29 3 3 CD cord-004862-yv76yvy5 45 30 ' ' POS cord-004862-yv76yvy5 45 31 untranslated untranslated JJ cord-004862-yv76yvy5 45 32 region region NN cord-004862-yv76yvy5 45 33 were be VBD cord-004862-yv76yvy5 45 34 identified identify VBN cord-004862-yv76yvy5 45 35 ( ( -LRB- cord-004862-yv76yvy5 45 36 Demers Demers NNP cord-004862-yv76yvy5 45 37 et et FW cord-004862-yv76yvy5 45 38 al al NNP cord-004862-yv76yvy5 45 39 . . NNP cord-004862-yv76yvy5 45 40 1986 1986 CD cord-004862-yv76yvy5 45 41 ) ) -RRB- cord-004862-yv76yvy5 45 42 . . . cord-004862-yv76yvy5 46 1 In in IN cord-004862-yv76yvy5 46 2 this this DT cord-004862-yv76yvy5 46 3 paper paper NN cord-004862-yv76yvy5 46 4 , , , cord-004862-yv76yvy5 46 5 the the DT cord-004862-yv76yvy5 46 6 rabbit rabbit NN cord-004862-yv76yvy5 46 7 L1 L1 NNP cord-004862-yv76yvy5 46 8 repeats repeat VBZ cord-004862-yv76yvy5 46 9 are be VBP cord-004862-yv76yvy5 46 10 characterized characterize VBN cord-004862-yv76yvy5 46 11 more more RBR cord-004862-yv76yvy5 46 12 thoroughly thoroughly RB cord-004862-yv76yvy5 46 13 , , , cord-004862-yv76yvy5 46 14 and and CC cord-004862-yv76yvy5 46 15 the the DT cord-004862-yv76yvy5 46 16 similarities similarity NNS cord-004862-yv76yvy5 46 17 and and CC cord-004862-yv76yvy5 46 18 differences difference NNS cord-004862-yv76yvy5 46 19 of of IN cord-004862-yv76yvy5 46 20 L1 L1 NNP cord-004862-yv76yvy5 46 21 sequences sequence NNS cord-004862-yv76yvy5 46 22 between between IN cord-004862-yv76yvy5 46 23 species specie NNS cord-004862-yv76yvy5 46 24 are be VBP cord-004862-yv76yvy5 46 25 explored explore VBN cord-004862-yv76yvy5 46 26 further further RB cord-004862-yv76yvy5 46 27 . . . cord-004862-yv76yvy5 47 1 Interspecies interspecies JJ cord-004862-yv76yvy5 47 2 comparisons comparison NNS cord-004862-yv76yvy5 47 3 reinforce reinforce VBP cord-004862-yv76yvy5 47 4 the the DT cord-004862-yv76yvy5 47 5 conclusion conclusion NN cord-004862-yv76yvy5 47 6 that that IN cord-004862-yv76yvy5 47 7 the the DT cord-004862-yv76yvy5 47 8 L1 L1 NNP cord-004862-yv76yvy5 47 9 repeat repeat NN cord-004862-yv76yvy5 47 10 has have VBZ cord-004862-yv76yvy5 47 11 two two CD cord-004862-yv76yvy5 47 12 ORFs orf NNS cord-004862-yv76yvy5 47 13 that that WDT cord-004862-yv76yvy5 47 14 are be VBP cord-004862-yv76yvy5 47 15 conserved conserve VBN cord-004862-yv76yvy5 47 16 for for IN cord-004862-yv76yvy5 47 17 their -PRON- PRP$ cord-004862-yv76yvy5 47 18 protein protein NN cord-004862-yv76yvy5 47 19 - - HYPH cord-004862-yv76yvy5 47 20 coding code VBG cord-004862-yv76yvy5 47 21 capacity capacity NN cord-004862-yv76yvy5 47 22 . . . cord-004862-yv76yvy5 48 1 However however RB cord-004862-yv76yvy5 48 2 , , , cord-004862-yv76yvy5 48 3 the the DT cord-004862-yv76yvy5 48 4 region region NN cord-004862-yv76yvy5 48 5 between between IN cord-004862-yv76yvy5 48 6 the the DT cord-004862-yv76yvy5 48 7 two two CD cord-004862-yv76yvy5 48 8 ORFs orfs NN cord-004862-yv76yvy5 48 9 is be VBZ cord-004862-yv76yvy5 48 10 not not RB cord-004862-yv76yvy5 48 11 conserved conserve VBN cord-004862-yv76yvy5 48 12 among among IN cord-004862-yv76yvy5 48 13 species specie NNS cord-004862-yv76yvy5 48 14 , , , cord-004862-yv76yvy5 48 15 and and CC cord-004862-yv76yvy5 48 16 this this DT cord-004862-yv76yvy5 48 17 observation observation NN cord-004862-yv76yvy5 48 18 is be VBZ cord-004862-yv76yvy5 48 19 used use VBN cord-004862-yv76yvy5 48 20 to to TO cord-004862-yv76yvy5 48 21 indicate indicate VB cord-004862-yv76yvy5 48 22 possible possible JJ cord-004862-yv76yvy5 48 23 start start VB cord-004862-yv76yvy5 48 24 and and CC cord-004862-yv76yvy5 48 25 stop stop VB cord-004862-yv76yvy5 48 26 codons codon NNS cord-004862-yv76yvy5 48 27 for for IN cord-004862-yv76yvy5 48 28 the the DT cord-004862-yv76yvy5 48 29 ORFs ORFs NNP cord-004862-yv76yvy5 48 30 . . . cord-004862-yv76yvy5 49 1 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 49 2 encodes encode VBZ cord-004862-yv76yvy5 49 3 a a DT cord-004862-yv76yvy5 49 4 composite composite JJ cord-004862-yv76yvy5 49 5 protein protein NN cord-004862-yv76yvy5 49 6 , , , cord-004862-yv76yvy5 49 7 and and CC cord-004862-yv76yvy5 49 8 the the DT cord-004862-yv76yvy5 49 9 5 5 CD cord-004862-yv76yvy5 49 10 ' ' CD cord-004862-yv76yvy5 49 11 half half NN cord-004862-yv76yvy5 49 12 of of IN cord-004862-yv76yvy5 49 13 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 50 1 from from IN cord-004862-yv76yvy5 50 2 L1Oc l1oc PRP cord-004862-yv76yvy5 51 1 is be VBZ cord-004862-yv76yvy5 51 2 related relate VBN cord-004862-yv76yvy5 51 3 to to IN cord-004862-yv76yvy5 51 4 type type NN cord-004862-yv76yvy5 51 5 II II NNP cord-004862-yv76yvy5 51 6 cytoskeletal cytoskeletal JJ cord-004862-yv76yvy5 51 7 keratin keratin NN cord-004862-yv76yvy5 51 8 . . . cord-004862-yv76yvy5 52 1 Subcloning Subcloning NNP cord-004862-yv76yvy5 52 2 and and CC cord-004862-yv76yvy5 52 3 Sequencing Sequencing NNP cord-004862-yv76yvy5 52 4 of of IN cord-004862-yv76yvy5 52 5 LlOc LlOc NNP cord-004862-yv76yvy5 52 6 Repeats repeat VBZ cord-004862-yv76yvy5 52 7 . . . cord-004862-yv76yvy5 53 1 The the DT cord-004862-yv76yvy5 53 2 sequenced sequence VBN cord-004862-yv76yvy5 53 3 members member NNS cord-004862-yv76yvy5 53 4 of of IN cord-004862-yv76yvy5 53 5 the the DT cord-004862-yv76yvy5 53 6 L1Oc L1Oc NNP cord-004862-yv76yvy5 53 7 family family NN cord-004862-yv76yvy5 53 8 were be VBD cord-004862-yv76yvy5 53 9 from from IN cord-004862-yv76yvy5 53 10 the the DT cord-004862-yv76yvy5 53 11 rabbit rabbit NN cord-004862-yv76yvy5 53 12 0-like 0-like CD cord-004862-yv76yvy5 53 13 globin globin NN cord-004862-yv76yvy5 53 14 gene gene NN cord-004862-yv76yvy5 53 15 cluster cluster NN cord-004862-yv76yvy5 53 16 isolated isolate VBN cord-004862-yv76yvy5 53 17 by by IN cord-004862-yv76yvy5 53 18 Lacy Lacy NNP cord-004862-yv76yvy5 53 19 et et FW cord-004862-yv76yvy5 53 20 al al NNP cord-004862-yv76yvy5 53 21 . . . cord-004862-yv76yvy5 54 1 ( ( -LRB- cord-004862-yv76yvy5 54 2 1979 1979 CD cord-004862-yv76yvy5 54 3 ) ) -RRB- cord-004862-yv76yvy5 54 4 . . . cord-004862-yv76yvy5 55 1 Interspersed intersperse VBN cord-004862-yv76yvy5 55 2 repetitive repetitive JJ cord-004862-yv76yvy5 55 3 DNA dna NN cord-004862-yv76yvy5 55 4 was be VBD cord-004862-yv76yvy5 55 5 identified identify VBN cord-004862-yv76yvy5 55 6 by by IN cord-004862-yv76yvy5 55 7 Shen Shen NNP cord-004862-yv76yvy5 55 8 and and CC cord-004862-yv76yvy5 55 9 Maniatis Maniatis NNP cord-004862-yv76yvy5 55 10 ( ( -LRB- cord-004862-yv76yvy5 55 11 1980 1980 CD cord-004862-yv76yvy5 55 12 ) ) -RRB- cord-004862-yv76yvy5 55 13 by by IN cord-004862-yv76yvy5 55 14 hybridization hybridization NN cord-004862-yv76yvy5 55 15 and and CC cord-004862-yv76yvy5 55 16 heteroduplex heteroduplex NN cord-004862-yv76yvy5 55 17 mapping mapping NN cord-004862-yv76yvy5 55 18 . . . cord-004862-yv76yvy5 56 1 The the DT cord-004862-yv76yvy5 56 2 five five CD cord-004862-yv76yvy5 56 3 L1 L1 NNP cord-004862-yv76yvy5 56 4 members member NNS cord-004862-yv76yvy5 56 5 ( ( -LRB- cord-004862-yv76yvy5 56 6 Demers Demers NNP cord-004862-yv76yvy5 56 7 et et FW cord-004862-yv76yvy5 56 8 al al NNP cord-004862-yv76yvy5 56 9 . . NNP cord-004862-yv76yvy5 56 10 1986 1986 CD cord-004862-yv76yvy5 56 11 ) ) -RRB- cord-004862-yv76yvy5 56 12 were be VBD cord-004862-yv76yvy5 56 13 sequenced sequence VBN cord-004862-yv76yvy5 56 14 by by IN cord-004862-yv76yvy5 56 15 dideoxynucleotide dideoxynucleotide NN cord-004862-yv76yvy5 56 16 chain chain NN cord-004862-yv76yvy5 56 17 termination termination NN cord-004862-yv76yvy5 56 18 reactions reaction NNS cord-004862-yv76yvy5 56 19 ( ( -LRB- cord-004862-yv76yvy5 56 20 Sanger Sanger NNP cord-004862-yv76yvy5 56 21 et et NNP cord-004862-yv76yvy5 56 22 al al NNP cord-004862-yv76yvy5 56 23 . . NNP cord-004862-yv76yvy5 56 24 1977 1977 CD cord-004862-yv76yvy5 56 25 ) ) -RRB- cord-004862-yv76yvy5 57 1 using use VBG cord-004862-yv76yvy5 57 2 subclones subclone NNS cord-004862-yv76yvy5 57 3 in in IN cord-004862-yv76yvy5 57 4 M13 M13 NNP cord-004862-yv76yvy5 57 5 phages phage NNS cord-004862-yv76yvy5 57 6 as as IN cord-004862-yv76yvy5 57 7 templates template NNS cord-004862-yv76yvy5 57 8 ( ( -LRB- cord-004862-yv76yvy5 57 9 Messing Messing NNP cord-004862-yv76yvy5 57 10 1983 1983 CD cord-004862-yv76yvy5 57 11 ) ) -RRB- cord-004862-yv76yvy5 57 12 . . . cord-004862-yv76yvy5 58 1 Analysis analysis NN cord-004862-yv76yvy5 58 2 of of IN cord-004862-yv76yvy5 58 3 DNA DNA NNP cord-004862-yv76yvy5 58 4 Sequences Sequences NNPS cord-004862-yv76yvy5 58 5 . . . cord-004862-yv76yvy5 59 1 Sequence sequence NN cord-004862-yv76yvy5 59 2 matches match NNS cord-004862-yv76yvy5 59 3 were be VBD cord-004862-yv76yvy5 59 4 first first RB cord-004862-yv76yvy5 59 5 identified identify VBN cord-004862-yv76yvy5 59 6 by by IN cord-004862-yv76yvy5 59 7 dot dot NN cord-004862-yv76yvy5 59 8 plots plot NNS cord-004862-yv76yvy5 59 9 generated generate VBN cord-004862-yv76yvy5 59 10 by by IN cord-004862-yv76yvy5 59 11 the the DT cord-004862-yv76yvy5 59 12 computer computer NN cord-004862-yv76yvy5 59 13 program program NN cord-004862-yv76yvy5 59 14 MATRIX MATRIX NNP cord-004862-yv76yvy5 59 15 ( ( -LRB- cord-004862-yv76yvy5 59 16 Zweig Zweig NNP cord-004862-yv76yvy5 59 17 1984 1984 CD cord-004862-yv76yvy5 59 18 ) ) -RRB- cord-004862-yv76yvy5 59 19 . . . cord-004862-yv76yvy5 60 1 This this DT cord-004862-yv76yvy5 60 2 provides provide VBZ cord-004862-yv76yvy5 60 3 a a DT cord-004862-yv76yvy5 60 4 graphical graphical JJ cord-004862-yv76yvy5 60 5 display display NN cord-004862-yv76yvy5 60 6 of of IN cord-004862-yv76yvy5 60 7 sequence sequence NN cord-004862-yv76yvy5 60 8 similarity similarity NN cord-004862-yv76yvy5 60 9 that that WDT cord-004862-yv76yvy5 60 10 plots plot VBZ cord-004862-yv76yvy5 60 11 matches match NNS cord-004862-yv76yvy5 60 12 ( ( -LRB- cord-004862-yv76yvy5 60 13 forward forward JJ cord-004862-yv76yvy5 60 14 similarity similarity NN cord-004862-yv76yvy5 60 15 ) ) -RRB- cord-004862-yv76yvy5 60 16 of of IN cord-004862-yv76yvy5 60 17 23 23 CD cord-004862-yv76yvy5 60 18 out out IN cord-004862-yv76yvy5 60 19 of of IN cord-004862-yv76yvy5 60 20 30 30 CD cord-004862-yv76yvy5 60 21 bases basis NNS cord-004862-yv76yvy5 60 22 . . . cord-004862-yv76yvy5 61 1 Similar similar JJ cord-004862-yv76yvy5 61 2 sequences sequence NNS cord-004862-yv76yvy5 61 3 were be VBD cord-004862-yv76yvy5 61 4 then then RB cord-004862-yv76yvy5 61 5 aligned align VBN cord-004862-yv76yvy5 61 6 by by IN cord-004862-yv76yvy5 61 7 the the DT cord-004862-yv76yvy5 61 8 computer computer NN cord-004862-yv76yvy5 61 9 program program NN cord-004862-yv76yvy5 61 10 NUCALN NUCALN NNP cord-004862-yv76yvy5 61 11 ( ( -LRB- cord-004862-yv76yvy5 61 12 Wilbur Wilbur NNP cord-004862-yv76yvy5 61 13 and and CC cord-004862-yv76yvy5 61 14 Lipman Lipman NNP cord-004862-yv76yvy5 61 15 1983 1983 CD cord-004862-yv76yvy5 61 16 ) ) -RRB- cord-004862-yv76yvy5 61 17 using use VBG cord-004862-yv76yvy5 61 18 the the DT cord-004862-yv76yvy5 61 19 parameters parameter NNS cord-004862-yv76yvy5 61 20 K k NN cord-004862-yv76yvy5 61 21 - - HYPH cord-004862-yv76yvy5 61 22 tuple tuple NN cord-004862-yv76yvy5 61 23 = = SYM cord-004862-yv76yvy5 61 24 3 3 CD cord-004862-yv76yvy5 61 25 , , , cord-004862-yv76yvy5 61 26 window window NN cord-004862-yv76yvy5 61 27 size size NN cord-004862-yv76yvy5 61 28 = = SYM cord-004862-yv76yvy5 61 29 20 20 CD cord-004862-yv76yvy5 61 30 , , , cord-004862-yv76yvy5 61 31 gap gap NN cord-004862-yv76yvy5 61 32 penalty penalty NN cord-004862-yv76yvy5 61 33 = = SYM cord-004862-yv76yvy5 61 34 7 7 CD cord-004862-yv76yvy5 61 35 . . . cord-004862-yv76yvy5 62 1 The the DT cord-004862-yv76yvy5 62 2 protein protein NN cord-004862-yv76yvy5 62 3 sequence sequence NN cord-004862-yv76yvy5 62 4 databases database NNS cord-004862-yv76yvy5 62 5 at at IN cord-004862-yv76yvy5 62 6 the the DT cord-004862-yv76yvy5 62 7 Protein Protein NNP cord-004862-yv76yvy5 62 8 Identification Identification NNP cord-004862-yv76yvy5 62 9 Resource Resource NNP cord-004862-yv76yvy5 62 10 ( ( -LRB- cord-004862-yv76yvy5 62 11 National National NNP cord-004862-yv76yvy5 62 12 Biomedical Biomedical NNP cord-004862-yv76yvy5 62 13 Research Research NNP cord-004862-yv76yvy5 62 14 Foundation Foundation NNP cord-004862-yv76yvy5 62 15 ) ) -RRB- cord-004862-yv76yvy5 62 16 were be VBD cord-004862-yv76yvy5 62 17 searched search VBN cord-004862-yv76yvy5 62 18 using use VBG cord-004862-yv76yvy5 62 19 the the DT cord-004862-yv76yvy5 62 20 FASTp fastp NN cord-004862-yv76yvy5 62 21 program program NN cord-004862-yv76yvy5 62 22 ( ( -LRB- cord-004862-yv76yvy5 62 23 Lipman Lipman NNP cord-004862-yv76yvy5 62 24 and and CC cord-004862-yv76yvy5 62 25 Pearson Pearson NNP cord-004862-yv76yvy5 62 26 1985 1985 CD cord-004862-yv76yvy5 62 27 ) ) -RRB- cord-004862-yv76yvy5 62 28 . . . cord-004862-yv76yvy5 63 1 The the DT cord-004862-yv76yvy5 63 2 statistical statistical JJ cord-004862-yv76yvy5 63 3 significance significance NN cord-004862-yv76yvy5 63 4 of of IN cord-004862-yv76yvy5 63 5 the the DT cord-004862-yv76yvy5 63 6 similarities similarity NNS cord-004862-yv76yvy5 63 7 found find VBN cord-004862-yv76yvy5 63 8 by by IN cord-004862-yv76yvy5 63 9 FASTp FASTp NNS cord-004862-yv76yvy5 63 10 were be VBD cord-004862-yv76yvy5 63 11 tested test VBN cord-004862-yv76yvy5 63 12 using use VBG cord-004862-yv76yvy5 63 13 the the DT cord-004862-yv76yvy5 63 14 program program NN cord-004862-yv76yvy5 63 15 RDF RDF NNP cord-004862-yv76yvy5 63 16 ( ( -LRB- cord-004862-yv76yvy5 63 17 National National NNP cord-004862-yv76yvy5 63 18 Biomedical Biomedical NNP cord-004862-yv76yvy5 63 19 Research Research NNP cord-004862-yv76yvy5 63 20 Foundation Foundation NNP cord-004862-yv76yvy5 63 21 ) ) -RRB- cord-004862-yv76yvy5 63 22 ; ; : cord-004862-yv76yvy5 63 23 this this DT cord-004862-yv76yvy5 63 24 program program NN cord-004862-yv76yvy5 63 25 scrambles scramble VBZ cord-004862-yv76yvy5 63 26 the the DT cord-004862-yv76yvy5 63 27 target target NN cord-004862-yv76yvy5 63 28 sequence sequence NN cord-004862-yv76yvy5 63 29 ( ( -LRB- cord-004862-yv76yvy5 63 30 revealed reveal VBN cord-004862-yv76yvy5 63 31 by by IN cord-004862-yv76yvy5 63 32 FASTp FASTp NNP cord-004862-yv76yvy5 63 33 ) ) -RRB- cord-004862-yv76yvy5 63 34 into into IN cord-004862-yv76yvy5 63 35 20 20 CD cord-004862-yv76yvy5 63 36 shuffled shuffle VBN cord-004862-yv76yvy5 63 37 sequences sequence NNS cord-004862-yv76yvy5 63 38 and and CC cord-004862-yv76yvy5 63 39 computes compute VBZ cord-004862-yv76yvy5 63 40 the the DT cord-004862-yv76yvy5 63 41 mean mean JJ cord-004862-yv76yvy5 63 42 similarity similarity NN cord-004862-yv76yvy5 63 43 score score NN cord-004862-yv76yvy5 63 44 for for IN cord-004862-yv76yvy5 63 45 the the DT cord-004862-yv76yvy5 63 46 shuffled shuffle VBN cord-004862-yv76yvy5 63 47 sequence sequence NN cord-004862-yv76yvy5 63 48 with with IN cord-004862-yv76yvy5 63 49 the the DT cord-004862-yv76yvy5 63 50 test test NN cord-004862-yv76yvy5 63 51 sequence sequence NN cord-004862-yv76yvy5 63 52 ( ( -LRB- cord-004862-yv76yvy5 63 53 in in IN cord-004862-yv76yvy5 63 54 this this DT cord-004862-yv76yvy5 63 55 case case NN cord-004862-yv76yvy5 63 56 , , , cord-004862-yv76yvy5 63 57 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 63 58 of of IN cord-004862-yv76yvy5 63 59 L L NNP cord-004862-yv76yvy5 63 60 10c 10c CD cord-004862-yv76yvy5 63 61 ) ) -RRB- cord-004862-yv76yvy5 63 62 . . . cord-004862-yv76yvy5 64 1 The the DT cord-004862-yv76yvy5 64 2 similarity similarity NN cord-004862-yv76yvy5 64 3 score score NN cord-004862-yv76yvy5 64 4 for for IN cord-004862-yv76yvy5 64 5 the the DT cord-004862-yv76yvy5 64 6 match match NN cord-004862-yv76yvy5 64 7 between between IN cord-004862-yv76yvy5 64 8 the the DT cord-004862-yv76yvy5 64 9 true true JJ cord-004862-yv76yvy5 64 10 sequences sequence NNS cord-004862-yv76yvy5 64 11 is be VBZ cord-004862-yv76yvy5 64 12 compared compare VBN cord-004862-yv76yvy5 64 13 with with IN cord-004862-yv76yvy5 64 14 the the DT cord-004862-yv76yvy5 64 15 mean mean JJ cord-004862-yv76yvy5 64 16 score score NN cord-004862-yv76yvy5 64 17 for for IN cord-004862-yv76yvy5 64 18 the the DT cord-004862-yv76yvy5 64 19 shuffled shuffle VBN cord-004862-yv76yvy5 64 20 sequences sequence NNS cord-004862-yv76yvy5 64 21 in in IN cord-004862-yv76yvy5 64 22 terms term NNS cord-004862-yv76yvy5 64 23 of of IN cord-004862-yv76yvy5 64 24 the the DT cord-004862-yv76yvy5 64 25 number number NN cord-004862-yv76yvy5 64 26 of of IN cord-004862-yv76yvy5 64 27 standard standard JJ cord-004862-yv76yvy5 64 28 deviations deviation NNS cord-004862-yv76yvy5 64 29 that that WDT cord-004862-yv76yvy5 64 30 separate separate VBP cord-004862-yv76yvy5 64 31 them -PRON- PRP cord-004862-yv76yvy5 64 32 . . . cord-004862-yv76yvy5 65 1 conditions condition NNS cord-004862-yv76yvy5 65 2 as as IN cord-004862-yv76yvy5 65 3 in in IN cord-004862-yv76yvy5 65 4 the the DT cord-004862-yv76yvy5 65 5 Southern southern JJ cord-004862-yv76yvy5 65 6 blot blot NN cord-004862-yv76yvy5 65 7 analysis analysis NN cord-004862-yv76yvy5 65 8 . . . cord-004862-yv76yvy5 66 1 The the DT cord-004862-yv76yvy5 66 2 ratio ratio NN cord-004862-yv76yvy5 66 3 of of IN cord-004862-yv76yvy5 66 4 percentage percentage NN cord-004862-yv76yvy5 66 5 of of IN cord-004862-yv76yvy5 66 6 plaques plaque NNS cord-004862-yv76yvy5 66 7 that that WDT cord-004862-yv76yvy5 66 8 hybridized hybridize VBD cord-004862-yv76yvy5 66 9 to to IN cord-004862-yv76yvy5 66 10 the the DT cord-004862-yv76yvy5 66 11 percentage percentage NN cord-004862-yv76yvy5 66 12 of of IN cord-004862-yv76yvy5 66 13 the the DT cord-004862-yv76yvy5 66 14 rabbit rabbit NN cord-004862-yv76yvy5 66 15 genome genome NN cord-004862-yv76yvy5 66 16 in in IN cord-004862-yv76yvy5 66 17 one one CD cord-004862-yv76yvy5 66 18 h h NN cord-004862-yv76yvy5 66 19 clone clone NN cord-004862-yv76yvy5 66 20 gives give VBZ cord-004862-yv76yvy5 66 21 the the DT cord-004862-yv76yvy5 66 22 approximate approximate JJ cord-004862-yv76yvy5 66 23 copy copy NN cord-004862-yv76yvy5 66 24 number number NN cord-004862-yv76yvy5 66 25 of of IN cord-004862-yv76yvy5 66 26 the the DT cord-004862-yv76yvy5 66 27 region region NN cord-004862-yv76yvy5 66 28 . . . cord-004862-yv76yvy5 67 1 The the DT cord-004862-yv76yvy5 67 2 average average JJ cord-004862-yv76yvy5 67 3 size size NN cord-004862-yv76yvy5 67 4 of of IN cord-004862-yv76yvy5 67 5 an an DT cord-004862-yv76yvy5 67 6 insert insert NN cord-004862-yv76yvy5 67 7 in in IN cord-004862-yv76yvy5 67 8 this this DT cord-004862-yv76yvy5 67 9 ~ ~ NFP cord-004862-yv76yvy5 67 10 , , , cord-004862-yv76yvy5 67 11 library library NN cord-004862-yv76yvy5 67 12 is be VBZ cord-004862-yv76yvy5 67 13 17 17 CD cord-004862-yv76yvy5 67 14 kb kb NNP cord-004862-yv76yvy5 68 1 ( ( -LRB- cord-004862-yv76yvy5 68 2 Maniatis Maniatis NNP cord-004862-yv76yvy5 68 3 et et NNP cord-004862-yv76yvy5 68 4 al al NNP cord-004862-yv76yvy5 68 5 . . . cord-004862-yv76yvy5 68 6 1978 1978 CD cord-004862-yv76yvy5 68 7 ) ) -RRB- cord-004862-yv76yvy5 68 8 . . . cord-004862-yv76yvy5 69 1 Thus thus RB cord-004862-yv76yvy5 69 2 , , , cord-004862-yv76yvy5 69 3 the the DT cord-004862-yv76yvy5 69 4 fraction fraction NN cord-004862-yv76yvy5 69 5 of of IN cord-004862-yv76yvy5 69 6 the the DT cord-004862-yv76yvy5 69 7 rabbit rabbit NN cord-004862-yv76yvy5 69 8 genome genome NN cord-004862-yv76yvy5 69 9 per per IN cord-004862-yv76yvy5 69 10 phage phage NN cord-004862-yv76yvy5 69 11 is be VBZ cord-004862-yv76yvy5 69 12 17 17 CD cord-004862-yv76yvy5 70 1 • • NNP cord-004862-yv76yvy5 71 1 103/3 103/3 CD cord-004862-yv76yvy5 72 1 x x SYM cord-004862-yv76yvy5 72 2 109 109 CD cord-004862-yv76yvy5 72 3 or or CC cord-004862-yv76yvy5 72 4 5.7 5.7 CD cord-004862-yv76yvy5 72 5 • • NNS cord-004862-yv76yvy5 72 6 10 10 CD cord-004862-yv76yvy5 72 7 - - SYM cord-004862-yv76yvy5 72 8 4 4 CD cord-004862-yv76yvy5 72 9 % % NN cord-004862-yv76yvy5 72 10 . . . cord-004862-yv76yvy5 73 1 The the DT cord-004862-yv76yvy5 73 2 fact fact NN cord-004862-yv76yvy5 73 3 that that IN cord-004862-yv76yvy5 73 4 96 96 CD cord-004862-yv76yvy5 73 5 % % NN cord-004862-yv76yvy5 73 6 of of IN cord-004862-yv76yvy5 73 7 the the DT cord-004862-yv76yvy5 73 8 phage phage NN cord-004862-yv76yvy5 73 9 in in IN cord-004862-yv76yvy5 73 10 the the DT cord-004862-yv76yvy5 73 11 library library NN cord-004862-yv76yvy5 73 12 have have VBP cord-004862-yv76yvy5 73 13 rabbit rabbit NN cord-004862-yv76yvy5 73 14 DNA dna NN cord-004862-yv76yvy5 73 15 ( ( -LRB- cord-004862-yv76yvy5 73 16 Maniatis Maniatis NNP cord-004862-yv76yvy5 73 17 et et NNP cord-004862-yv76yvy5 73 18 al al NNP cord-004862-yv76yvy5 73 19 . . . cord-004862-yv76yvy5 73 20 1978 1978 CD cord-004862-yv76yvy5 73 21 ) ) -RRB- cord-004862-yv76yvy5 73 22 was be VBD cord-004862-yv76yvy5 73 23 also also RB cord-004862-yv76yvy5 73 24 taken take VBN cord-004862-yv76yvy5 73 25 into into IN cord-004862-yv76yvy5 73 26 account account NN cord-004862-yv76yvy5 73 27 . . . cord-004862-yv76yvy5 74 1 Rodent rodent NN cord-004862-yv76yvy5 74 2 and and CC cord-004862-yv76yvy5 74 3 Human Human NNP cord-004862-yv76yvy5 74 4 L1 L1 NNP cord-004862-yv76yvy5 74 5 Sequences Sequences NNPS cord-004862-yv76yvy5 74 6 . . . cord-004862-yv76yvy5 75 1 The the DT cord-004862-yv76yvy5 75 2 mouse mouse NN cord-004862-yv76yvy5 75 3 LI LI NNP cord-004862-yv76yvy5 75 4 sequence sequence NN cord-004862-yv76yvy5 75 5 , , , cord-004862-yv76yvy5 75 6 LIMdA2 LIMdA2 NNP cord-004862-yv76yvy5 75 7 , , , cord-004862-yv76yvy5 75 8 and and CC cord-004862-yv76yvy5 75 9 the the DT cord-004862-yv76yvy5 75 10 rat rat NN cord-004862-yv76yvy5 75 11 LI LI NNP cord-004862-yv76yvy5 75 12 sequence sequence NN cord-004862-yv76yvy5 75 13 , , , cord-004862-yv76yvy5 75 14 L1Rn L1Rn NNP cord-004862-yv76yvy5 75 15 or or CC cord-004862-yv76yvy5 75 16 LINE3 line3 JJ cord-004862-yv76yvy5 76 1 ( ( -LRB- cord-004862-yv76yvy5 76 2 D'Ambrosio D'Ambrosio NNP cord-004862-yv76yvy5 76 3 et et NNP cord-004862-yv76yvy5 76 4 al al NNP cord-004862-yv76yvy5 76 5 . . . cord-004862-yv76yvy5 76 6 1986 1986 CD cord-004862-yv76yvy5 76 7 ) ) -RRB- cord-004862-yv76yvy5 76 8 are be VBP cord-004862-yv76yvy5 76 9 randomly randomly RB cord-004862-yv76yvy5 76 10 isolated isolate VBN cord-004862-yv76yvy5 76 11 L1 L1 NNP cord-004862-yv76yvy5 76 12 members member NNS cord-004862-yv76yvy5 76 13 from from IN cord-004862-yv76yvy5 76 14 their -PRON- PRP$ cord-004862-yv76yvy5 76 15 respective respective JJ cord-004862-yv76yvy5 76 16 genomes genome NNS cord-004862-yv76yvy5 76 17 . . . cord-004862-yv76yvy5 77 1 The the DT cord-004862-yv76yvy5 77 2 human human JJ cord-004862-yv76yvy5 77 3 L1 l1 NN cord-004862-yv76yvy5 77 4 sequence sequence NN cord-004862-yv76yvy5 77 5 , , , cord-004862-yv76yvy5 77 6 L1Hs L1Hs NNP cord-004862-yv76yvy5 77 7 - - HYPH cord-004862-yv76yvy5 77 8 TBG41 TBG41 NNP cord-004862-yv76yvy5 77 9 , , , cord-004862-yv76yvy5 77 10 is be VBZ cord-004862-yv76yvy5 77 11 located locate VBN cord-004862-yv76yvy5 77 12 3.3 3.3 CD cord-004862-yv76yvy5 77 13 kb kb NNP cord-004862-yv76yvy5 77 14 3 3 CD cord-004862-yv76yvy5 77 15 ' ' '' cord-004862-yv76yvy5 77 16 to to IN cord-004862-yv76yvy5 77 17 the the DT cord-004862-yv76yvy5 77 18 human/]-globin human/]-globin NNP cord-004862-yv76yvy5 77 19 gene gene NN cord-004862-yv76yvy5 77 20 ( ( -LRB- cord-004862-yv76yvy5 77 21 Hanori Hanori NNP cord-004862-yv76yvy5 77 22 et et NNP cord-004862-yv76yvy5 77 23 al al NNP cord-004862-yv76yvy5 77 24 . . . cord-004862-yv76yvy5 77 25 1985 1985 CD cord-004862-yv76yvy5 77 26 ) ) -RRB- cord-004862-yv76yvy5 77 27 . . . cord-004862-yv76yvy5 78 1 A a DT cord-004862-yv76yvy5 78 2 consensus consensus NN cord-004862-yv76yvy5 78 3 L1Hs l1hs CD cord-004862-yv76yvy5 78 4 sequence sequence NN cord-004862-yv76yvy5 78 5 ( ( -LRB- cord-004862-yv76yvy5 78 6 Scott Scott NNP cord-004862-yv76yvy5 78 7 et et NNP cord-004862-yv76yvy5 78 8 al al NNP cord-004862-yv76yvy5 78 9 . . NNP cord-004862-yv76yvy5 78 10 1987 1987 CD cord-004862-yv76yvy5 78 11 ) ) -RRB- cord-004862-yv76yvy5 78 12 was be VBD cord-004862-yv76yvy5 78 13 used use VBN cord-004862-yv76yvy5 78 14 in in IN cord-004862-yv76yvy5 78 15 the the DT cord-004862-yv76yvy5 78 16 analysis analysis NN cord-004862-yv76yvy5 78 17 of of IN cord-004862-yv76yvy5 78 18 ORF ORF NNP cord-004862-yv76yvy5 78 19 - - HYPH cord-004862-yv76yvy5 78 20 I I NNP cord-004862-yv76yvy5 78 21 in in IN cord-004862-yv76yvy5 78 22 Fig Fig NNP cord-004862-yv76yvy5 78 23 . . . cord-004862-yv76yvy5 79 1 8 8 CD cord-004862-yv76yvy5 79 2 . . . cord-004862-yv76yvy5 80 1 The the DT cord-004862-yv76yvy5 80 2 interspersion interspersion NN cord-004862-yv76yvy5 80 3 of of IN cord-004862-yv76yvy5 80 4 repetitive repetitive JJ cord-004862-yv76yvy5 80 5 sequences sequence NNS cord-004862-yv76yvy5 80 6 among among IN cord-004862-yv76yvy5 80 7 the the DT cord-004862-yv76yvy5 80 8 rabbit rabbit NN cord-004862-yv76yvy5 80 9 B b NN cord-004862-yv76yvy5 80 10 - - HYPH cord-004862-yv76yvy5 80 11 like like JJ cord-004862-yv76yvy5 80 12 globin globin NN cord-004862-yv76yvy5 80 13 genes gene NNS cord-004862-yv76yvy5 80 14 is be VBZ cord-004862-yv76yvy5 80 15 shown show VBN cord-004862-yv76yvy5 80 16 in in IN cord-004862-yv76yvy5 80 17 Fig Fig NNP cord-004862-yv76yvy5 80 18 . . . cord-004862-yv76yvy5 81 1 1 1 LS cord-004862-yv76yvy5 81 2 . . . cord-004862-yv76yvy5 82 1 The the DT cord-004862-yv76yvy5 82 2 genes gene NNS cord-004862-yv76yvy5 82 3 ~ ~ NFP cord-004862-yv76yvy5 82 4 and and CC cord-004862-yv76yvy5 82 5 7 7 CD cord-004862-yv76yvy5 82 6 ( ( -LRB- cord-004862-yv76yvy5 82 7 formerly/34 formerly/34 NNP cord-004862-yv76yvy5 82 8 and/33 and/33 NNP cord-004862-yv76yvy5 82 9 ) ) -RRB- cord-004862-yv76yvy5 82 10 are be VBP cord-004862-yv76yvy5 82 11 expressed express VBN cord-004862-yv76yvy5 82 12 in in IN cord-004862-yv76yvy5 82 13 embryonic embryonic JJ cord-004862-yv76yvy5 82 14 development development NN cord-004862-yv76yvy5 82 15 ( ( -LRB- cord-004862-yv76yvy5 82 16 Rohrbaugh Rohrbaugh NNP cord-004862-yv76yvy5 82 17 and and CC cord-004862-yv76yvy5 82 18 Hardison Hardison NNP cord-004862-yv76yvy5 82 19 1983 1983 CD cord-004862-yv76yvy5 82 20 ) ) -RRB- cord-004862-yv76yvy5 82 21 , , . cord-004862-yv76yvy5 83 1 ~ ~ NFP cord-004862-yv76yvy5 83 2 ( ( -LRB- cord-004862-yv76yvy5 83 3 ~b/32 ~b/32 NFP cord-004862-yv76yvy5 83 4 ) ) -RRB- cord-004862-yv76yvy5 83 5 is be VBZ cord-004862-yv76yvy5 83 6 an an DT cord-004862-yv76yvy5 83 7 inactive inactive JJ cord-004862-yv76yvy5 83 8 pseudogene pseudogene NN cord-004862-yv76yvy5 83 9 ( ( -LRB- cord-004862-yv76yvy5 83 10 Lacy Lacy NNP cord-004862-yv76yvy5 83 11 and and CC cord-004862-yv76yvy5 83 12 Maniatis Maniatis NNP cord-004862-yv76yvy5 83 13 1980 1980 CD cord-004862-yv76yvy5 83 14 ) ) -RRB- cord-004862-yv76yvy5 83 15 , , , cord-004862-yv76yvy5 83 16 and/3 and/3 NNP cord-004862-yv76yvy5 83 17 ( ( -LRB- cord-004862-yv76yvy5 83 18 /31 /31 NNP cord-004862-yv76yvy5 83 19 ) ) -RRB- cord-004862-yv76yvy5 83 20 is be VBZ cord-004862-yv76yvy5 83 21 expressed express VBN cord-004862-yv76yvy5 83 22 in in IN cord-004862-yv76yvy5 83 23 fetal fetal JJ cord-004862-yv76yvy5 83 24 and and CC cord-004862-yv76yvy5 83 25 adult adult NN cord-004862-yv76yvy5 83 26 life life NN cord-004862-yv76yvy5 83 27 ( ( -LRB- cord-004862-yv76yvy5 83 28 Hardison Hardison NNP cord-004862-yv76yvy5 83 29 et et NNP cord-004862-yv76yvy5 83 30 al al NNP cord-004862-yv76yvy5 83 31 . . . cord-004862-yv76yvy5 83 32 1979 1979 CD cord-004862-yv76yvy5 83 33 ; ; . cord-004862-yv76yvy5 84 1 Rohrbaugh Rohrbaugh NNP cord-004862-yv76yvy5 84 2 et et NNP cord-004862-yv76yvy5 84 3 al al NNP cord-004862-yv76yvy5 84 4 . . . cord-004862-yv76yvy5 84 5 1985 1985 CD cord-004862-yv76yvy5 84 6 ) ) -RRB- cord-004862-yv76yvy5 84 7 . . . cord-004862-yv76yvy5 85 1 The the DT cord-004862-yv76yvy5 85 2 5 5 CD cord-004862-yv76yvy5 85 3 ' ' '' cord-004862-yv76yvy5 85 4 to to IN cord-004862-yv76yvy5 85 5 3 3 CD cord-004862-yv76yvy5 85 6 ' ' '' cord-004862-yv76yvy5 85 7 orientations orientation NNS cord-004862-yv76yvy5 85 8 of of IN cord-004862-yv76yvy5 85 9 the the DT cord-004862-yv76yvy5 85 10 proposed propose VBN cord-004862-yv76yvy5 85 11 RNA RNA NNP cord-004862-yv76yvy5 85 12 intermediates intermediate NNS cord-004862-yv76yvy5 85 13 of of IN cord-004862-yv76yvy5 85 14 the the DT cord-004862-yv76yvy5 85 15 repetitive repetitive JJ cord-004862-yv76yvy5 85 16 elements element NNS cord-004862-yv76yvy5 85 17 are be VBP cord-004862-yv76yvy5 85 18 indicated indicate VBN cord-004862-yv76yvy5 85 19 by by IN cord-004862-yv76yvy5 85 20 the the DT cord-004862-yv76yvy5 85 21 arrows arrow NNS cord-004862-yv76yvy5 85 22 in in IN cord-004862-yv76yvy5 85 23 Fig Fig NNP cord-004862-yv76yvy5 85 24 . . . cord-004862-yv76yvy5 86 1 1 1 LS cord-004862-yv76yvy5 86 2 ; ; : cord-004862-yv76yvy5 86 3 the the DT cord-004862-yv76yvy5 86 4 A a RB cord-004862-yv76yvy5 86 5 - - HYPH cord-004862-yv76yvy5 86 6 rich rich JJ cord-004862-yv76yvy5 86 7 tracts tract NNS cord-004862-yv76yvy5 86 8 are be VBP cord-004862-yv76yvy5 86 9 at at IN cord-004862-yv76yvy5 86 10 the the DT cord-004862-yv76yvy5 86 11 3 3 CD cord-004862-yv76yvy5 86 12 ' ' '' cord-004862-yv76yvy5 86 13 ends end NNS cord-004862-yv76yvy5 86 14 . . . cord-004862-yv76yvy5 87 1 The the DT cord-004862-yv76yvy5 87 2 sequences sequence NNS cord-004862-yv76yvy5 87 3 of of IN cord-004862-yv76yvy5 87 4 the the DT cord-004862-yv76yvy5 87 5 five five CD cord-004862-yv76yvy5 87 6 L1Oc L1Oc NNP cord-004862-yv76yvy5 87 7 repeats repeat NNS cord-004862-yv76yvy5 87 8 are be VBP cord-004862-yv76yvy5 87 9 presented present VBN cord-004862-yv76yvy5 87 10 in in IN cord-004862-yv76yvy5 87 11 Fig Fig NNP cord-004862-yv76yvy5 87 12 . . . cord-004862-yv76yvy5 88 1 2 2 LS cord-004862-yv76yvy5 88 2 . . . cord-004862-yv76yvy5 89 1 L1Oc5 L1Oc5 NNP cord-004862-yv76yvy5 89 2 is be VBZ cord-004862-yv76yvy5 89 3 adjacent adjacent JJ cord-004862-yv76yvy5 89 4 to to IN cord-004862-yv76yvy5 89 5 L1 L1 NNP cord-004862-yv76yvy5 89 6 Oc4 Oc4 NNP cord-004862-yv76yvy5 90 1 ( ( -LRB- cord-004862-yv76yvy5 90 2 Fig Fig NNP cord-004862-yv76yvy5 90 3 . . NNP cord-004862-yv76yvy5 90 4 1 1 CD cord-004862-yv76yvy5 90 5 ) ) -RRB- cord-004862-yv76yvy5 90 6 , , , cord-004862-yv76yvy5 90 7 so so CC cord-004862-yv76yvy5 90 8 the the DT cord-004862-yv76yvy5 90 9 last last JJ cord-004862-yv76yvy5 90 10 nucleotide nucleotide NN cord-004862-yv76yvy5 90 11 in in IN cord-004862-yv76yvy5 90 12 the the DT cord-004862-yv76yvy5 90 13 L1 L1 NNP cord-004862-yv76yvy5 90 14 Oc5 oc5 NN cord-004862-yv76yvy5 90 15 sequence sequence NN cord-004862-yv76yvy5 90 16 is be VBZ cord-004862-yv76yvy5 90 17 followed follow VBN cord-004862-yv76yvy5 90 18 by by IN cord-004862-yv76yvy5 90 19 the the DT cord-004862-yv76yvy5 90 20 first first JJ cord-004862-yv76yvy5 90 21 nucleotide nucleotide NN cord-004862-yv76yvy5 90 22 in in IN cord-004862-yv76yvy5 90 23 the the DT cord-004862-yv76yvy5 90 24 L1 L1 NNP cord-004862-yv76yvy5 90 25 Oc4 Oc4 NNP cord-004862-yv76yvy5 90 26 sequence sequence NN cord-004862-yv76yvy5 90 27 ( ( -LRB- cord-004862-yv76yvy5 90 28 Fig Fig NNP cord-004862-yv76yvy5 90 29 . . NNP cord-004862-yv76yvy5 90 30 2 2 CD cord-004862-yv76yvy5 90 31 ) ) -RRB- cord-004862-yv76yvy5 90 32 in in IN cord-004862-yv76yvy5 90 33 the the DT cord-004862-yv76yvy5 90 34 sequence sequence NN cord-004862-yv76yvy5 90 35 of of IN cord-004862-yv76yvy5 90 36 the the DT cord-004862-yv76yvy5 90 37 gene gene NN cord-004862-yv76yvy5 90 38 cluster cluster NN cord-004862-yv76yvy5 90 39 ( ( -LRB- cord-004862-yv76yvy5 90 40 Margot Margot NNP cord-004862-yv76yvy5 90 41 et et NNP cord-004862-yv76yvy5 90 42 al al NNP cord-004862-yv76yvy5 90 43 . . NNP cord-004862-yv76yvy5 90 44 1989 1989 CD cord-004862-yv76yvy5 90 45 ) ) -RRB- cord-004862-yv76yvy5 90 46 . . . cord-004862-yv76yvy5 91 1 The the DT cord-004862-yv76yvy5 91 2 longest long JJS cord-004862-yv76yvy5 91 3 member member NN cord-004862-yv76yvy5 91 4 of of IN cord-004862-yv76yvy5 91 5 the the DT cord-004862-yv76yvy5 91 6 rabbit rabbit NN cord-004862-yv76yvy5 91 7 L1 L1 NNP cord-004862-yv76yvy5 91 8 family family NN cord-004862-yv76yvy5 91 9 in in IN cord-004862-yv76yvy5 91 10 the the DT cord-004862-yv76yvy5 91 11 /3-like /3-like JJ cord-004862-yv76yvy5 91 12 globin globin NN cord-004862-yv76yvy5 91 13 gene gene NN cord-004862-yv76yvy5 91 14 cluster cluster NN cord-004862-yv76yvy5 91 15 is be VBZ cord-004862-yv76yvy5 91 16 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 91 17 . . . cord-004862-yv76yvy5 92 1 The the DT cord-004862-yv76yvy5 92 2 next next JJ cord-004862-yv76yvy5 92 3 longest long JJS cord-004862-yv76yvy5 92 4 member member NN cord-004862-yv76yvy5 92 5 is be VBZ cord-004862-yv76yvy5 92 6 LI LI NNP cord-004862-yv76yvy5 92 7 Oc4 Oc4 NNP cord-004862-yv76yvy5 92 8 ; ; : cord-004862-yv76yvy5 92 9 it -PRON- PRP cord-004862-yv76yvy5 92 10 has have VBZ cord-004862-yv76yvy5 92 11 an an DT cord-004862-yv76yvy5 92 12 internal internal JJ cord-004862-yv76yvy5 92 13 deletion deletion NN cord-004862-yv76yvy5 92 14 of of IN cord-004862-yv76yvy5 92 15 667 667 CD cord-004862-yv76yvy5 92 16 bp bp NNP cord-004862-yv76yvy5 92 17 ( ( -LRB- cord-004862-yv76yvy5 92 18 Fig Fig NNP cord-004862-yv76yvy5 92 19 . . NNP cord-004862-yv76yvy5 92 20 2 2 CD cord-004862-yv76yvy5 92 21 , , , cord-004862-yv76yvy5 92 22 . . . cord-004862-yv76yvy5 93 1 This this DT cord-004862-yv76yvy5 93 2 is be VBZ cord-004862-yv76yvy5 93 3 clearly clearly RB cord-004862-yv76yvy5 93 4 a a DT cord-004862-yv76yvy5 93 5 deletion deletion NN cord-004862-yv76yvy5 93 6 from from IN cord-004862-yv76yvy5 93 7 L L NNP cord-004862-yv76yvy5 93 8 I -PRON- PRP cord-004862-yv76yvy5 93 9 Oc4 Oc4 VBD cord-004862-yv76yvy5 93 10 and and CC cord-004862-yv76yvy5 93 11 not not RB cord-004862-yv76yvy5 93 12 an an DT cord-004862-yv76yvy5 93 13 insertion insertion NN cord-004862-yv76yvy5 93 14 in in IN cord-004862-yv76yvy5 93 15 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 93 16 because because IN cord-004862-yv76yvy5 93 17 a a DT cord-004862-yv76yvy5 93 18 similar similar JJ cord-004862-yv76yvy5 93 19 sequence sequence NN cord-004862-yv76yvy5 93 20 is be VBZ cord-004862-yv76yvy5 93 21 present present JJ cord-004862-yv76yvy5 93 22 in in IN cord-004862-yv76yvy5 93 23 both both DT cord-004862-yv76yvy5 93 24 mouse mouse NN cord-004862-yv76yvy5 93 25 and and CC cord-004862-yv76yvy5 93 26 human human JJ cord-004862-yv76yvy5 93 27 Lls Lls NNP cord-004862-yv76yvy5 93 28 ( ( -LRB- cord-004862-yv76yvy5 93 29 Demers Demers NNP cord-004862-yv76yvy5 93 30 et et FW cord-004862-yv76yvy5 93 31 al al NNP cord-004862-yv76yvy5 93 32 . . NNP cord-004862-yv76yvy5 93 33 1986 1986 CD cord-004862-yv76yvy5 93 34 ) ) -RRB- cord-004862-yv76yvy5 93 35 . . . cord-004862-yv76yvy5 94 1 L1 L1 NNP cord-004862-yv76yvy5 94 2 Oc5 oc5 NN cord-004862-yv76yvy5 94 3 will will MD cord-004862-yv76yvy5 94 4 be be VB cord-004862-yv76yvy5 94 5 the the DT cord-004862-yv76yvy5 94 6 prototypical prototypical JJ cord-004862-yv76yvy5 94 7 rabbit rabbit NN cord-004862-yv76yvy5 94 8 L1 l1 NN cord-004862-yv76yvy5 94 9 for for IN cord-004862-yv76yvy5 94 10 further further JJ cord-004862-yv76yvy5 94 11 analysis analysis NN cord-004862-yv76yvy5 94 12 because because IN cord-004862-yv76yvy5 94 13 it -PRON- PRP cord-004862-yv76yvy5 94 14 is be VBZ cord-004862-yv76yvy5 94 15 the the DT cord-004862-yv76yvy5 94 16 longest long JJS cord-004862-yv76yvy5 94 17 and and CC cord-004862-yv76yvy5 94 18 has have VBZ cord-004862-yv76yvy5 94 19 no no DT cord-004862-yv76yvy5 94 20 extensive extensive JJ cord-004862-yv76yvy5 94 21 internal internal JJ cord-004862-yv76yvy5 94 22 deletions deletion NNS cord-004862-yv76yvy5 94 23 . . . cord-004862-yv76yvy5 95 1 The the DT cord-004862-yv76yvy5 95 2 5 5 CD cord-004862-yv76yvy5 95 3 ' ' NN cord-004862-yv76yvy5 95 4 end end NN cord-004862-yv76yvy5 95 5 of of IN cord-004862-yv76yvy5 95 6 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 95 7 is be VBZ cord-004862-yv76yvy5 95 8 also also RB cord-004862-yv76yvy5 95 9 the the DT cord-004862-yv76yvy5 95 10 end end NN cord-004862-yv76yvy5 95 11 of of IN cord-004862-yv76yvy5 95 12 the the DT cord-004862-yv76yvy5 95 13 cloned clone VBN cord-004862-yv76yvy5 95 14 region region NN cord-004862-yv76yvy5 95 15 of of IN cord-004862-yv76yvy5 95 16 the the DT cord-004862-yv76yvy5 95 17 rabbit rabbit NN cord-004862-yv76yvy5 96 1 /3-like /3-like JJ cord-004862-yv76yvy5 96 2 globin globin NN cord-004862-yv76yvy5 96 3 gene gene NN cord-004862-yv76yvy5 96 4 cluster cluster NN cord-004862-yv76yvy5 96 5 ( ( -LRB- cord-004862-yv76yvy5 96 6 see see VB cord-004862-yv76yvy5 96 7 Fig Fig NNP cord-004862-yv76yvy5 96 8 . . NNP cord-004862-yv76yvy5 96 9 1 1 CD cord-004862-yv76yvy5 96 10 ) ) -RRB- cord-004862-yv76yvy5 96 11 . . . cord-004862-yv76yvy5 97 1 Only only RB cord-004862-yv76yvy5 97 2 two two CD cord-004862-yv76yvy5 97 3 of of IN cord-004862-yv76yvy5 97 4 the the DT cord-004862-yv76yvy5 97 5 Shen Shen NNP cord-004862-yv76yvy5 97 6 and and CC cord-004862-yv76yvy5 97 7 Maniatis Maniatis NNP cord-004862-yv76yvy5 97 8 ( ( -LRB- cord-004862-yv76yvy5 97 9 1980 1980 CD cord-004862-yv76yvy5 97 10 ) ) -RRB- cord-004862-yv76yvy5 97 11 are be VBP cord-004862-yv76yvy5 97 12 shown show VBN cord-004862-yv76yvy5 97 13 at at IN cord-004862-yv76yvy5 97 14 the the DT cord-004862-yv76yvy5 97 15 bottom bottom NN cord-004862-yv76yvy5 97 16 of of IN cord-004862-yv76yvy5 97 17 the the DT cord-004862-yv76yvy5 97 18 diagram diagram NN cord-004862-yv76yvy5 97 19 . . . cord-004862-yv76yvy5 98 1 individual individual NNP cord-004862-yv76yvy5 98 2 repeats repeat VBZ cord-004862-yv76yvy5 98 3 , , , cord-004862-yv76yvy5 98 4 L1Oc4 L1Oc4 NNP cord-004862-yv76yvy5 98 5 and and CC cord-004862-yv76yvy5 98 6 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 98 7 , , , cord-004862-yv76yvy5 98 8 contain contain VBP cord-004862-yv76yvy5 98 9 sequences sequence NNS cord-004862-yv76yvy5 98 10 for for IN cord-004862-yv76yvy5 98 11 the the DT cord-004862-yv76yvy5 98 12 ORF ORF NNP cord-004862-yv76yvy5 98 13 region region NN cord-004862-yv76yvy5 98 14 ( ( -LRB- cord-004862-yv76yvy5 98 15 Demers Demers NNP cord-004862-yv76yvy5 98 16 et et FW cord-004862-yv76yvy5 98 17 al al NNP cord-004862-yv76yvy5 98 18 . . NNP cord-004862-yv76yvy5 98 19 1986 1986 CD cord-004862-yv76yvy5 98 20 ) ) -RRB- cord-004862-yv76yvy5 98 21 . . . cord-004862-yv76yvy5 99 1 The the DT cord-004862-yv76yvy5 99 2 other other JJ cord-004862-yv76yvy5 99 3 three three CD cord-004862-yv76yvy5 99 4 repeats repeat NNS cord-004862-yv76yvy5 99 5 contain contain VBP cord-004862-yv76yvy5 99 6 part part NN cord-004862-yv76yvy5 99 7 or or CC cord-004862-yv76yvy5 99 8 all all DT cord-004862-yv76yvy5 99 9 of of IN cord-004862-yv76yvy5 99 10 the the DT cord-004862-yv76yvy5 99 11 3 3 CD cord-004862-yv76yvy5 99 12 ' ' POS cord-004862-yv76yvy5 99 13 untranslated untranslated JJ cord-004862-yv76yvy5 99 14 region region NN cord-004862-yv76yvy5 99 15 . . . cord-004862-yv76yvy5 100 1 L1Oc5 L1Oc5 NNP cord-004862-yv76yvy5 100 2 and and CC cord-004862-yv76yvy5 100 3 L1Ocl L1Ocl NNP cord-004862-yv76yvy5 100 4 have have VBP cord-004862-yv76yvy5 100 5 internal internal JJ cord-004862-yv76yvy5 100 6 direct direct JJ cord-004862-yv76yvy5 100 7 repeats repeat NNS cord-004862-yv76yvy5 100 8 of of IN cord-004862-yv76yvy5 100 9 78 78 CD cord-004862-yv76yvy5 100 10 bp bp NNS cord-004862-yv76yvy5 100 11 in in IN cord-004862-yv76yvy5 100 12 the the DT cord-004862-yv76yvy5 100 13 3 3 CD cord-004862-yv76yvy5 100 14 ' ' POS cord-004862-yv76yvy5 100 15 untranslated untranslated JJ cord-004862-yv76yvy5 100 16 region region NN cord-004862-yv76yvy5 100 17 . . . cord-004862-yv76yvy5 101 1 One one CD cord-004862-yv76yvy5 101 2 copy copy NN cord-004862-yv76yvy5 101 3 of of IN cord-004862-yv76yvy5 101 4 the the DT cord-004862-yv76yvy5 101 5 repeat repeat NN cord-004862-yv76yvy5 101 6 is be VBZ cord-004862-yv76yvy5 101 7 at at IN cord-004862-yv76yvy5 101 8 positions position NNS cord-004862-yv76yvy5 101 9 6015 6015 CD cord-004862-yv76yvy5 101 10 - - SYM cord-004862-yv76yvy5 101 11 6092 6092 CD cord-004862-yv76yvy5 101 12 and and CC cord-004862-yv76yvy5 101 13 the the DT cord-004862-yv76yvy5 101 14 other other JJ cord-004862-yv76yvy5 101 15 is be VBZ cord-004862-yv76yvy5 101 16 at at IN cord-004862-yv76yvy5 101 17 positions position NNS cord-004862-yv76yvy5 101 18 6212 6212 CD cord-004862-yv76yvy5 101 19 - - HYPH cord-004862-yv76yvy5 101 20 6289 6289 CD cord-004862-yv76yvy5 101 21 ( ( -LRB- cord-004862-yv76yvy5 101 22 lower low JJR cord-004862-yv76yvy5 101 23 case case NN cord-004862-yv76yvy5 101 24 letters letter NNS cord-004862-yv76yvy5 101 25 in in IN cord-004862-yv76yvy5 101 26 Fig Fig NNP cord-004862-yv76yvy5 101 27 . . . cord-004862-yv76yvy5 101 28 _SP cord-004862-yv76yvy5 101 29 2 2 CD cord-004862-yv76yvy5 101 30 ) ) -RRB- cord-004862-yv76yvy5 101 31 . . . cord-004862-yv76yvy5 102 1 L1Oc4 L1Oc4 NNP cord-004862-yv76yvy5 102 2 and and CC cord-004862-yv76yvy5 102 3 L1Oc3 L1Oc3 NNP cord-004862-yv76yvy5 102 4 have have VBP cord-004862-yv76yvy5 102 5 only only RB cord-004862-yv76yvy5 102 6 one one CD cord-004862-yv76yvy5 102 7 copy copy NN cord-004862-yv76yvy5 102 8 of of IN cord-004862-yv76yvy5 102 9 this this DT cord-004862-yv76yvy5 102 10 78-bp 78-bp CD cord-004862-yv76yvy5 102 11 sequence sequence NN cord-004862-yv76yvy5 102 12 , , , cord-004862-yv76yvy5 102 13 and and CC cord-004862-yv76yvy5 102 14 they -PRON- PRP cord-004862-yv76yvy5 102 15 do do VBP cord-004862-yv76yvy5 102 16 not not RB cord-004862-yv76yvy5 102 17 contain contain VB cord-004862-yv76yvy5 102 18 the the DT cord-004862-yv76yvy5 102 19 sequence sequence NN cord-004862-yv76yvy5 102 20 between between IN cord-004862-yv76yvy5 102 21 the the DT cord-004862-yv76yvy5 102 22 78-bp 78-bp CD cord-004862-yv76yvy5 102 23 direct direct JJ cord-004862-yv76yvy5 102 24 repeat repeat NN cord-004862-yv76yvy5 102 25 ( ( -LRB- cord-004862-yv76yvy5 102 26 present present JJ cord-004862-yv76yvy5 102 27 in in IN cord-004862-yv76yvy5 102 28 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 102 29 and and CC cord-004862-yv76yvy5 102 30 L1Ocl L1Ocl NNP cord-004862-yv76yvy5 102 31 ) ) -RRB- cord-004862-yv76yvy5 102 32 . . . cord-004862-yv76yvy5 103 1 Thus thus RB cord-004862-yv76yvy5 103 2 , , , cord-004862-yv76yvy5 103 3 the the DT cord-004862-yv76yvy5 103 4 class class NN cord-004862-yv76yvy5 103 5 of of IN cord-004862-yv76yvy5 103 6 L1Oc L1Oc NNP cord-004862-yv76yvy5 103 7 repeats repeat VBZ cord-004862-yv76yvy5 103 8 containing contain VBG cord-004862-yv76yvy5 103 9 one one CD cord-004862-yv76yvy5 103 10 copy copy NN cord-004862-yv76yvy5 103 11 of of IN cord-004862-yv76yvy5 103 12 the the DT cord-004862-yv76yvy5 103 13 78-bp 78-bp CD cord-004862-yv76yvy5 103 14 sequence sequence NN cord-004862-yv76yvy5 103 15 could could MD cord-004862-yv76yvy5 103 16 be be VB cord-004862-yv76yvy5 103 17 derived derive VBN cord-004862-yv76yvy5 103 18 from from IN cord-004862-yv76yvy5 103 19 the the DT cord-004862-yv76yvy5 103 20 class class NN cord-004862-yv76yvy5 103 21 containing contain VBG cord-004862-yv76yvy5 103 22 two two CD cord-004862-yv76yvy5 103 23 copies copy NNS cord-004862-yv76yvy5 103 24 by by IN cord-004862-yv76yvy5 103 25 a a DT cord-004862-yv76yvy5 103 26 deletion deletion NN cord-004862-yv76yvy5 103 27 between between IN cord-004862-yv76yvy5 103 28 the the DT cord-004862-yv76yvy5 103 29 two two CD cord-004862-yv76yvy5 103 30 78-bp 78-bp CD cord-004862-yv76yvy5 103 31 sequences sequence NNS cord-004862-yv76yvy5 103 32 . . . cord-004862-yv76yvy5 104 1 Another another DT cord-004862-yv76yvy5 104 2 example example NN cord-004862-yv76yvy5 104 3 of of IN cord-004862-yv76yvy5 104 4 a a DT cord-004862-yv76yvy5 104 5 sequence sequence NN cord-004862-yv76yvy5 104 6 rearrangement rearrangement NN cord-004862-yv76yvy5 104 7 is be VBZ cord-004862-yv76yvy5 104 8 the the DT cord-004862-yv76yvy5 104 9 apparent apparent JJ cord-004862-yv76yvy5 104 10 insertion insertion NN cord-004862-yv76yvy5 104 11 of of IN cord-004862-yv76yvy5 104 12 34 34 CD cord-004862-yv76yvy5 104 13 bp bp NNP cord-004862-yv76yvy5 104 14 into into IN cord-004862-yv76yvy5 104 15 L L NNP cord-004862-yv76yvy5 104 16 10e4 10e4 CD cord-004862-yv76yvy5 104 17 between between IN cord-004862-yv76yvy5 104 18 positions position NNS cord-004862-yv76yvy5 104 19 5701 5701 CD cord-004862-yv76yvy5 104 20 - - SYM cord-004862-yv76yvy5 104 21 5702 5702 CD cord-004862-yv76yvy5 104 22 of of IN cord-004862-yv76yvy5 104 23 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 104 24 . . . cord-004862-yv76yvy5 105 1 Most Most JJS cord-004862-yv76yvy5 105 2 members member NNS cord-004862-yv76yvy5 105 3 of of IN cord-004862-yv76yvy5 105 4 the the DT cord-004862-yv76yvy5 105 5 L1Oc L1Oc NNP cord-004862-yv76yvy5 105 6 family family NN cord-004862-yv76yvy5 105 7 are be VBP cord-004862-yv76yvy5 105 8 flanked flank VBN cord-004862-yv76yvy5 105 9 by by IN cord-004862-yv76yvy5 105 10 short short JJ cord-004862-yv76yvy5 105 11 direct direct JJ cord-004862-yv76yvy5 105 12 repeats repeat NNS cord-004862-yv76yvy5 105 13 . . . cord-004862-yv76yvy5 106 1 L L NNP cord-004862-yv76yvy5 106 2 10c 10c NNP cord-004862-yv76yvy5 106 3 1 1 CD cord-004862-yv76yvy5 106 4 and and CC cord-004862-yv76yvy5 106 5 L l NN cord-004862-yv76yvy5 106 6 1 1 CD cord-004862-yv76yvy5 106 7 Oc2 oc2 CD cord-004862-yv76yvy5 106 8 are be VBP cord-004862-yv76yvy5 106 9 flanked flank VBN cord-004862-yv76yvy5 106 10 by by IN cord-004862-yv76yvy5 106 11 direct direct JJ cord-004862-yv76yvy5 106 12 repeats repeat NNS cord-004862-yv76yvy5 106 13 of of IN cord-004862-yv76yvy5 106 14 9 9 CD cord-004862-yv76yvy5 106 15 bp bp NNP cord-004862-yv76yvy5 106 16 and and CC cord-004862-yv76yvy5 106 17 5 5 CD cord-004862-yv76yvy5 106 18 bp bp NNP cord-004862-yv76yvy5 106 19 , , , cord-004862-yv76yvy5 106 20 respectively respectively RB cord-004862-yv76yvy5 106 21 ( ( -LRB- cord-004862-yv76yvy5 106 22 Fig fig NN cord-004862-yv76yvy5 106 23 . . . cord-004862-yv76yvy5 106 24 _SP cord-004862-yv76yvy5 106 25 2 2 CD cord-004862-yv76yvy5 106 26 ) ) -RRB- cord-004862-yv76yvy5 106 27 . . . cord-004862-yv76yvy5 107 1 The the DT cord-004862-yv76yvy5 107 2 flanking flank VBG cord-004862-yv76yvy5 107 3 direct direct JJ cord-004862-yv76yvy5 107 4 repeats repeat NNS cord-004862-yv76yvy5 107 5 differ differ VBP cord-004862-yv76yvy5 107 6 for for IN cord-004862-yv76yvy5 107 7 the the DT cord-004862-yv76yvy5 107 8 two two CD cord-004862-yv76yvy5 107 9 individual individual JJ cord-004862-yv76yvy5 107 10 L L NNP cord-004862-yv76yvy5 107 11 1 1 CD cord-004862-yv76yvy5 107 12 repeats repeat VBZ cord-004862-yv76yvy5 107 13 , , , cord-004862-yv76yvy5 107 14 showing show VBG cord-004862-yv76yvy5 107 15 that that IN cord-004862-yv76yvy5 107 16 they -PRON- PRP cord-004862-yv76yvy5 107 17 are be VBP cord-004862-yv76yvy5 107 18 not not RB cord-004862-yv76yvy5 107 19 part part NN cord-004862-yv76yvy5 107 20 of of IN cord-004862-yv76yvy5 107 21 the the DT cord-004862-yv76yvy5 107 22 L1 L1 NNP cord-004862-yv76yvy5 107 23 sequence sequence NN cord-004862-yv76yvy5 107 24 . . . cord-004862-yv76yvy5 108 1 Such such JJ cord-004862-yv76yvy5 108 2 flanking flank VBG cord-004862-yv76yvy5 108 3 direct direct JJ cord-004862-yv76yvy5 108 4 repeats repeat NNS cord-004862-yv76yvy5 108 5 are be VBP cord-004862-yv76yvy5 108 6 often often RB cord-004862-yv76yvy5 108 7 generated generate VBN cord-004862-yv76yvy5 108 8 by by IN cord-004862-yv76yvy5 108 9 insertion insertion NN cord-004862-yv76yvy5 108 10 of of IN cord-004862-yv76yvy5 108 11 transposable transposable JJ cord-004862-yv76yvy5 108 12 elements element NNS cord-004862-yv76yvy5 108 13 presumably presumably RB cord-004862-yv76yvy5 108 14 by by IN cord-004862-yv76yvy5 108 15 repair repair NN cord-004862-yv76yvy5 108 16 of of IN cord-004862-yv76yvy5 108 17 a a DT cord-004862-yv76yvy5 108 18 staggered staggered JJ cord-004862-yv76yvy5 108 19 break break NN cord-004862-yv76yvy5 108 20 at at IN cord-004862-yv76yvy5 108 21 the the DT cord-004862-yv76yvy5 108 22 target target NN cord-004862-yv76yvy5 108 23 site site NN cord-004862-yv76yvy5 108 24 . . . cord-004862-yv76yvy5 109 1 The the DT cord-004862-yv76yvy5 109 2 flanking flank VBG cord-004862-yv76yvy5 109 3 direct direct JJ cord-004862-yv76yvy5 109 4 repeats repeat NNS cord-004862-yv76yvy5 109 5 for for IN cord-004862-yv76yvy5 109 6 L l NN cord-004862-yv76yvy5 109 7 1 1 CD cord-004862-yv76yvy5 109 8 Oc4 oc4 CD cord-004862-yv76yvy5 109 9 and and CC cord-004862-yv76yvy5 109 10 L1Oc5 L1Oc5 NNP cord-004862-yv76yvy5 109 11 can can MD cord-004862-yv76yvy5 109 12 not not RB cord-004862-yv76yvy5 109 13 be be VB cord-004862-yv76yvy5 109 14 identified identify VBN cord-004862-yv76yvy5 109 15 with with IN cord-004862-yv76yvy5 109 16 the the DT cord-004862-yv76yvy5 109 17 available available JJ cord-004862-yv76yvy5 109 18 data datum NNS cord-004862-yv76yvy5 109 19 . . . cord-004862-yv76yvy5 110 1 The the DT cord-004862-yv76yvy5 110 2 5 5 CD cord-004862-yv76yvy5 110 3 ' ' NN cord-004862-yv76yvy5 110 4 end end NN cord-004862-yv76yvy5 110 5 of of IN cord-004862-yv76yvy5 110 6 L1Oe5 L1Oe5 NNP cord-004862-yv76yvy5 110 7 has have VBZ cord-004862-yv76yvy5 110 8 not not RB cord-004862-yv76yvy5 110 9 been be VBN cord-004862-yv76yvy5 110 10 cloned clone VBN cord-004862-yv76yvy5 110 11 . . . cord-004862-yv76yvy5 111 1 Because because IN cord-004862-yv76yvy5 111 2 L1 L1 NNP cord-004862-yv76yvy5 111 3 Oc5 oc5 NN cord-004862-yv76yvy5 111 4 is be VBZ cord-004862-yv76yvy5 111 5 juxtaposed juxtapose VBN cord-004862-yv76yvy5 111 6 to to IN cord-004862-yv76yvy5 111 7 LI LI NNP cord-004862-yv76yvy5 111 8 Oc4 Oc4 NNP cord-004862-yv76yvy5 111 9 , , , cord-004862-yv76yvy5 111 10 it -PRON- PRP cord-004862-yv76yvy5 111 11 is be VBZ cord-004862-yv76yvy5 111 12 possible possible JJ cord-004862-yv76yvy5 111 13 that that IN cord-004862-yv76yvy5 111 14 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 111 15 may may MD cord-004862-yv76yvy5 111 16 have have VB cord-004862-yv76yvy5 111 17 inserted insert VBN cord-004862-yv76yvy5 111 18 into into IN cord-004862-yv76yvy5 111 19 L1Oc4 L1Oc4 NNP cord-004862-yv76yvy5 111 20 , , , cord-004862-yv76yvy5 111 21 in in IN cord-004862-yv76yvy5 111 22 which which WDT cord-004862-yv76yvy5 111 23 case case NN cord-004862-yv76yvy5 111 24 the the DT cord-004862-yv76yvy5 111 25 5 5 CD cord-004862-yv76yvy5 111 26 ' ' NN cord-004862-yv76yvy5 111 27 end end NN cord-004862-yv76yvy5 111 28 of of IN cord-004862-yv76yvy5 111 29 L1Oc4 L1Oc4 NNP cord-004862-yv76yvy5 111 30 is be VBZ cord-004862-yv76yvy5 111 31 also also RB cord-004862-yv76yvy5 111 32 not not RB cord-004862-yv76yvy5 111 33 available available JJ cord-004862-yv76yvy5 111 34 . . . cord-004862-yv76yvy5 112 1 The the DT cord-004862-yv76yvy5 112 2 only only JJ cord-004862-yv76yvy5 112 3 other other JJ cord-004862-yv76yvy5 112 4 L1 L1 NNP cord-004862-yv76yvy5 112 5 member member NN cord-004862-yv76yvy5 112 6 , , , cord-004862-yv76yvy5 112 7 L1Oc3 L1Oc3 NNP cord-004862-yv76yvy5 112 8 , , , cord-004862-yv76yvy5 112 9 does do VBZ cord-004862-yv76yvy5 112 10 not not RB cord-004862-yv76yvy5 112 11 have have VB cord-004862-yv76yvy5 112 12 obvious obvious JJ cord-004862-yv76yvy5 112 13 flanking flank VBG cord-004862-yv76yvy5 112 14 direct direct JJ cord-004862-yv76yvy5 112 15 repeats repeat NNS cord-004862-yv76yvy5 112 16 generated generate VBN cord-004862-yv76yvy5 112 17 by by IN cord-004862-yv76yvy5 112 18 a a DT cord-004862-yv76yvy5 112 19 duplication duplication NN cord-004862-yv76yvy5 112 20 of of IN cord-004862-yv76yvy5 112 21 the the DT cord-004862-yv76yvy5 112 22 target target NN cord-004862-yv76yvy5 112 23 site site NN cord-004862-yv76yvy5 112 24 . . . cord-004862-yv76yvy5 113 1 The the DT cord-004862-yv76yvy5 113 2 sequence sequence NN cord-004862-yv76yvy5 113 3 GTTAAAAAAA GTTAAAAAAA NNP cord-004862-yv76yvy5 113 4 found find VBD cord-004862-yv76yvy5 113 5 just just RB cord-004862-yv76yvy5 113 6 3 3 CD cord-004862-yv76yvy5 113 7 ' ' '' cord-004862-yv76yvy5 113 8 to to IN cord-004862-yv76yvy5 113 9 the the DT cord-004862-yv76yvy5 113 10 polyadenylation polyadenylation NN cord-004862-yv76yvy5 113 11 site site NN cord-004862-yv76yvy5 113 12 ( ( -LRB- cord-004862-yv76yvy5 113 13 positions position NNS cord-004862-yv76yvy5 113 14 6438 6438 CD cord-004862-yv76yvy5 113 15 - - SYM cord-004862-yv76yvy5 113 16 6447 6447 CD cord-004862-yv76yvy5 113 17 ) ) -RRB- cord-004862-yv76yvy5 113 18 is be VBZ cord-004862-yv76yvy5 113 19 also also RB cord-004862-yv76yvy5 113 20 found find VBN cord-004862-yv76yvy5 113 21 upstream upstream RB cord-004862-yv76yvy5 113 22 from from IN cord-004862-yv76yvy5 113 23 L1Oc3 L1Oc3 NNP cord-004862-yv76yvy5 113 24 ( ( -LRB- cord-004862-yv76yvy5 113 25 Margot Margot NNP cord-004862-yv76yvy5 113 26 et et NNP cord-004862-yv76yvy5 113 27 al al NNP cord-004862-yv76yvy5 113 28 . . NNP cord-004862-yv76yvy5 113 29 1989 1989 CD cord-004862-yv76yvy5 113 30 ) ) -RRB- cord-004862-yv76yvy5 113 31 . . . cord-004862-yv76yvy5 114 1 However however RB cord-004862-yv76yvy5 114 2 , , , cord-004862-yv76yvy5 114 3 because because IN cord-004862-yv76yvy5 114 4 the the DT cord-004862-yv76yvy5 114 5 sequence sequence NN cord-004862-yv76yvy5 114 6 GTT(A)7 GTT(A)7 NNP cord-004862-yv76yvy5 114 7 ( ( -LRB- cord-004862-yv76yvy5 114 8 or or CC cord-004862-yv76yvy5 114 9 a a DT cord-004862-yv76yvy5 114 10 slight slight JJ cord-004862-yv76yvy5 114 11 variation variation NN cord-004862-yv76yvy5 114 12 ofi0 ofi0 NN cord-004862-yv76yvy5 114 13 is be VBZ cord-004862-yv76yvy5 114 14 also also RB cord-004862-yv76yvy5 114 15 found find VBN cord-004862-yv76yvy5 114 16 in in IN cord-004862-yv76yvy5 114 17 all all DT cord-004862-yv76yvy5 114 18 of of IN cord-004862-yv76yvy5 114 19 the the DT cord-004862-yv76yvy5 114 20 other other JJ cord-004862-yv76yvy5 114 21 L1 L1 NNP cord-004862-yv76yvy5 114 22 sequences sequence NNS cord-004862-yv76yvy5 114 23 just just RB cord-004862-yv76yvy5 114 24 3 3 CD cord-004862-yv76yvy5 114 25 ' ' '' cord-004862-yv76yvy5 114 26 to to IN cord-004862-yv76yvy5 114 27 the the DT cord-004862-yv76yvy5 114 28 polyadenylation polyadenylation NN cord-004862-yv76yvy5 114 29 signal signal NN cord-004862-yv76yvy5 114 30 , , , cord-004862-yv76yvy5 114 31 it -PRON- PRP cord-004862-yv76yvy5 114 32 is be VBZ cord-004862-yv76yvy5 114 33 likely likely JJ cord-004862-yv76yvy5 114 34 not not RB cord-004862-yv76yvy5 114 35 to to TO cord-004862-yv76yvy5 114 36 have have VB cord-004862-yv76yvy5 114 37 been be VBN cord-004862-yv76yvy5 114 38 generated generate VBN cord-004862-yv76yvy5 114 39 by by IN cord-004862-yv76yvy5 114 40 a a DT cord-004862-yv76yvy5 114 41 target target NN cord-004862-yv76yvy5 114 42 site site NN cord-004862-yv76yvy5 114 43 duplication duplication NN cord-004862-yv76yvy5 114 44 around around IN cord-004862-yv76yvy5 114 45 L1Oc3 L1Oc3 NNP cord-004862-yv76yvy5 114 46 . . . cord-004862-yv76yvy5 115 1 This this DT cord-004862-yv76yvy5 115 2 terminal terminal JJ cord-004862-yv76yvy5 115 3 repetition repetition NN cord-004862-yv76yvy5 115 4 could could MD cord-004862-yv76yvy5 115 5 be be VB cord-004862-yv76yvy5 115 6 generated generate VBN cord-004862-yv76yvy5 115 7 by by IN cord-004862-yv76yvy5 115 8 insertion insertion NN cord-004862-yv76yvy5 115 9 of of IN cord-004862-yv76yvy5 115 10 a a DT cord-004862-yv76yvy5 115 11 circular circular JJ cord-004862-yv76yvy5 115 12 form form NN cord-004862-yv76yvy5 115 13 of of IN cord-004862-yv76yvy5 115 14 L1 L1 NNP cord-004862-yv76yvy5 115 15 by by IN cord-004862-yv76yvy5 115 16 homologous homologous JJ cord-004862-yv76yvy5 115 17 recombination recombination NN cord-004862-yv76yvy5 115 18 into into IN cord-004862-yv76yvy5 115 19 a a DT cord-004862-yv76yvy5 115 20 GTT(A)7 GTT(A)7 NNP cord-004862-yv76yvy5 115 21 sequence sequence NN cord-004862-yv76yvy5 115 22 at at IN cord-004862-yv76yvy5 115 23 the the DT cord-004862-yv76yvy5 115 24 target target NN cord-004862-yv76yvy5 115 25 site site NN cord-004862-yv76yvy5 115 26 . . . cord-004862-yv76yvy5 116 1 The the DT cord-004862-yv76yvy5 116 2 structural structural JJ cord-004862-yv76yvy5 116 3 features feature NNS cord-004862-yv76yvy5 116 4 revealed reveal VBN cord-004862-yv76yvy5 116 5 by by IN cord-004862-yv76yvy5 116 6 the the DT cord-004862-yv76yvy5 116 7 alignment alignment NN cord-004862-yv76yvy5 116 8 and and CC cord-004862-yv76yvy5 116 9 comparison comparison NN cord-004862-yv76yvy5 116 10 of of IN cord-004862-yv76yvy5 116 11 the the DT cord-004862-yv76yvy5 116 12 L1 L1 NNP cord-004862-yv76yvy5 116 13 members member NNS cord-004862-yv76yvy5 116 14 from from IN cord-004862-yv76yvy5 116 15 the the DT cord-004862-yv76yvy5 116 16 rabbit rabbit NN cord-004862-yv76yvy5 116 17 ~3 ~3 RBS cord-004862-yv76yvy5 116 18 - - HYPH cord-004862-yv76yvy5 116 19 1ike 1ike CD cord-004862-yv76yvy5 116 20 globin globin NN cord-004862-yv76yvy5 116 21 gene gene NN cord-004862-yv76yvy5 116 22 cluster cluster NN cord-004862-yv76yvy5 116 23 are be VBP cord-004862-yv76yvy5 116 24 summarized summarize VBN cord-004862-yv76yvy5 116 25 in in IN cord-004862-yv76yvy5 116 26 Fig Fig NNP cord-004862-yv76yvy5 116 27 . . . cord-004862-yv76yvy5 117 1 3 3 LS cord-004862-yv76yvy5 117 2 . . . cord-004862-yv76yvy5 118 1 The the DT cord-004862-yv76yvy5 118 2 B b NN cord-004862-yv76yvy5 118 3 , , , cord-004862-yv76yvy5 118 4 E E NNP cord-004862-yv76yvy5 118 5 , , , cord-004862-yv76yvy5 118 6 and and CC cord-004862-yv76yvy5 118 7 D D NNP cord-004862-yv76yvy5 118 8 repeats repeat NNS cord-004862-yv76yvy5 118 9 identified identify VBN cord-004862-yv76yvy5 118 10 by by IN cord-004862-yv76yvy5 118 11 Shen Shen NNP cord-004862-yv76yvy5 118 12 and and CC cord-004862-yv76yvy5 118 13 Maniatis Maniatis NNP cord-004862-yv76yvy5 118 14 ( ( -LRB- cord-004862-yv76yvy5 118 15 1980 1980 CD cord-004862-yv76yvy5 118 16 ) ) -RRB- cord-004862-yv76yvy5 118 17 are be VBP cord-004862-yv76yvy5 118 18 also also RB cord-004862-yv76yvy5 118 19 aligned align VBN cord-004862-yv76yvy5 118 20 with with IN cord-004862-yv76yvy5 118 21 their -PRON- PRP$ cord-004862-yv76yvy5 118 22 position position NN cord-004862-yv76yvy5 118 23 in in IN cord-004862-yv76yvy5 118 24 the the DT cord-004862-yv76yvy5 118 25 L10c l10c FW cord-004862-yv76yvy5 118 26 sequence sequence NN cord-004862-yv76yvy5 118 27 . . . cord-004862-yv76yvy5 119 1 The the DT cord-004862-yv76yvy5 119 2 D d NN cord-004862-yv76yvy5 119 3 repeat repeat NN cord-004862-yv76yvy5 119 4 is be VBZ cord-004862-yv76yvy5 119 5 confined confine VBN cord-004862-yv76yvy5 119 6 to to IN cord-004862-yv76yvy5 119 7 the the DT cord-004862-yv76yvy5 119 8 3 3 CD cord-004862-yv76yvy5 119 9 ' ' POS cord-004862-yv76yvy5 119 10 untranslated untranslated JJ cord-004862-yv76yvy5 119 11 region region NN cord-004862-yv76yvy5 119 12 , , , cord-004862-yv76yvy5 119 13 whereas whereas IN cord-004862-yv76yvy5 119 14 the the DT cord-004862-yv76yvy5 119 15 B b NN cord-004862-yv76yvy5 119 16 repeat repeat NN cord-004862-yv76yvy5 119 17 and and CC cord-004862-yv76yvy5 119 18 most most JJS cord-004862-yv76yvy5 119 19 of of IN cord-004862-yv76yvy5 119 20 the the DT cord-004862-yv76yvy5 119 21 E e NN cord-004862-yv76yvy5 119 22 repeat repeat NN cord-004862-yv76yvy5 119 23 are be VBP cord-004862-yv76yvy5 119 24 from from IN cord-004862-yv76yvy5 119 25 the the DT cord-004862-yv76yvy5 119 26 ORF ORF NNP cord-004862-yv76yvy5 119 27 region region NN cord-004862-yv76yvy5 119 28 . . . cord-004862-yv76yvy5 120 1 L1Ocl L1Ocl NNP cord-004862-yv76yvy5 120 2 begins begin VBZ cord-004862-yv76yvy5 120 3 immediately immediately RB cord-004862-yv76yvy5 120 4 after after IN cord-004862-yv76yvy5 120 5 the the DT cord-004862-yv76yvy5 120 6 conserved conserve VBN cord-004862-yv76yvy5 120 7 translation translation NN cord-004862-yv76yvy5 120 8 stop stop NN cord-004862-yv76yvy5 120 9 codon codon NNP cord-004862-yv76yvy5 120 10 . . . cord-004862-yv76yvy5 121 1 Figure figure NN cord-004862-yv76yvy5 121 2 3 3 CD cord-004862-yv76yvy5 121 3 also also RB cord-004862-yv76yvy5 121 4 illustrates illustrate VBZ cord-004862-yv76yvy5 121 5 the the DT cord-004862-yv76yvy5 121 6 internal internal JJ cord-004862-yv76yvy5 121 7 sequence sequence NN cord-004862-yv76yvy5 121 8 rearrangements rearrangement NNS cord-004862-yv76yvy5 121 9 described describe VBN cord-004862-yv76yvy5 121 10 above above RB cord-004862-yv76yvy5 121 11 . . . cord-004862-yv76yvy5 122 1 The the DT cord-004862-yv76yvy5 122 2 diagram diagram NN cord-004862-yv76yvy5 122 3 of of IN cord-004862-yv76yvy5 122 4 L1Oc L1Oc NNP cord-004862-yv76yvy5 122 5 repeats repeat VBZ cord-004862-yv76yvy5 122 6 in in IN cord-004862-yv76yvy5 122 7 Fig Fig NNP cord-004862-yv76yvy5 122 8 . . . cord-004862-yv76yvy5 123 1 3 3 CD cord-004862-yv76yvy5 123 2 shows show VBZ cord-004862-yv76yvy5 123 3 that that IN cord-004862-yv76yvy5 123 4 they -PRON- PRP cord-004862-yv76yvy5 123 5 are be VBP cord-004862-yv76yvy5 123 6 truncated truncate VBN cord-004862-yv76yvy5 123 7 at at IN cord-004862-yv76yvy5 123 8 a a DT cord-004862-yv76yvy5 123 9 variable variable JJ cord-004862-yv76yvy5 123 10 distance distance NN cord-004862-yv76yvy5 123 11 from from IN cord-004862-yv76yvy5 123 12 the the DT cord-004862-yv76yvy5 123 13 5 5 CD cord-004862-yv76yvy5 123 14 ' ' NN cord-004862-yv76yvy5 123 15 end end NN cord-004862-yv76yvy5 123 16 of of IN cord-004862-yv76yvy5 123 17 the the DT cord-004862-yv76yvy5 123 18 longest long JJS cord-004862-yv76yvy5 123 19 elements element NNS cord-004862-yv76yvy5 123 20 . . . cord-004862-yv76yvy5 124 1 This this DT cord-004862-yv76yvy5 124 2 truncation truncation NN cord-004862-yv76yvy5 124 3 from from IN cord-004862-yv76yvy5 124 4 the the DT cord-004862-yv76yvy5 124 5 5 5 CD cord-004862-yv76yvy5 124 6 ' ' '' cord-004862-yv76yvy5 124 7 ends end NNS cord-004862-yv76yvy5 124 8 is be VBZ cord-004862-yv76yvy5 124 9 common common JJ cord-004862-yv76yvy5 124 10 in in IN cord-004862-yv76yvy5 124 11 the the DT cord-004862-yv76yvy5 124 12 whole whole JJ cord-004862-yv76yvy5 124 13 population population NN cord-004862-yv76yvy5 124 14 of of IN cord-004862-yv76yvy5 124 15 LI LI NNP cord-004862-yv76yvy5 124 16 repeats repeat VBZ cord-004862-yv76yvy5 124 17 , , , cord-004862-yv76yvy5 124 18 as as IN cord-004862-yv76yvy5 124 19 demonstrated demonstrate VBN cord-004862-yv76yvy5 124 20 by by IN cord-004862-yv76yvy5 124 21 using use VBG cord-004862-yv76yvy5 124 22 four four CD cord-004862-yv76yvy5 124 23 regions region NNS cord-004862-yv76yvy5 124 24 of of IN cord-004862-yv76yvy5 124 25 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 124 26 as as IN cord-004862-yv76yvy5 124 27 probes probe NNS cord-004862-yv76yvy5 124 28 against against IN cord-004862-yv76yvy5 124 29 the the DT cord-004862-yv76yvy5 124 30 rabbit rabbit NN cord-004862-yv76yvy5 124 31 genomic genomic JJ cord-004862-yv76yvy5 124 32 DNA DNA NNP cord-004862-yv76yvy5 124 33 library library NN cord-004862-yv76yvy5 124 34 in in IN cord-004862-yv76yvy5 124 35 a a DT cord-004862-yv76yvy5 124 36 plaque plaque NN cord-004862-yv76yvy5 124 37 hybridization hybridization NN cord-004862-yv76yvy5 124 38 assay assay NN cord-004862-yv76yvy5 124 39 . . . cord-004862-yv76yvy5 125 1 By by IN cord-004862-yv76yvy5 125 2 counting count VBG cord-004862-yv76yvy5 125 3 the the DT cord-004862-yv76yvy5 125 4 number number NN cord-004862-yv76yvy5 125 5 of of IN cord-004862-yv76yvy5 125 6 plaques plaque NNS cord-004862-yv76yvy5 125 7 that that WDT cord-004862-yv76yvy5 125 8 hybridized hybridize VBD cord-004862-yv76yvy5 125 9 to to IN cord-004862-yv76yvy5 125 10 a a DT cord-004862-yv76yvy5 125 11 given give VBN cord-004862-yv76yvy5 125 12 probe probe NN cord-004862-yv76yvy5 125 13 , , , cord-004862-yv76yvy5 125 14 the the DT cord-004862-yv76yvy5 125 15 approximate approximate JJ cord-004862-yv76yvy5 125 16 copy copy NN cord-004862-yv76yvy5 125 17 number number NN cord-004862-yv76yvy5 125 18 of of IN cord-004862-yv76yvy5 125 19 each each DT cord-004862-yv76yvy5 125 20 region region NN cord-004862-yv76yvy5 125 21 of of IN cord-004862-yv76yvy5 125 22 the the DT cord-004862-yv76yvy5 125 23 L1Oc5 L1Oc5 NNP cord-004862-yv76yvy5 125 24 repeat repeat NN cord-004862-yv76yvy5 125 25 was be VBD cord-004862-yv76yvy5 125 26 determined determine VBN cord-004862-yv76yvy5 125 27 ( ( -LRB- cord-004862-yv76yvy5 125 28 see see VB cord-004862-yv76yvy5 125 29 Materials material NNS cord-004862-yv76yvy5 125 30 and and CC cord-004862-yv76yvy5 125 31 Methods Methods NNPS cord-004862-yv76yvy5 125 32 ) ) -RRB- cord-004862-yv76yvy5 125 33 . . . cord-004862-yv76yvy5 126 1 As as IN cord-004862-yv76yvy5 126 2 shown show VBN cord-004862-yv76yvy5 126 3 in in IN cord-004862-yv76yvy5 126 4 Fig Fig NNP cord-004862-yv76yvy5 126 5 . . . cord-004862-yv76yvy5 127 1 4 4 LS cord-004862-yv76yvy5 127 2 , , , cord-004862-yv76yvy5 127 3 the the DT cord-004862-yv76yvy5 127 4 5'-most 5'-most CD cord-004862-yv76yvy5 127 5 region region NN cord-004862-yv76yvy5 127 6 of of IN cord-004862-yv76yvy5 127 7 LIOc5 LIOc5 NNP cord-004862-yv76yvy5 127 8 is be VBZ cord-004862-yv76yvy5 127 9 represented represent VBN cord-004862-yv76yvy5 127 10 about about IN cord-004862-yv76yvy5 127 11 11,000 11,000 CD cord-004862-yv76yvy5 127 12 times time NNS cord-004862-yv76yvy5 127 13 in in IN cord-004862-yv76yvy5 127 14 the the DT cord-004862-yv76yvy5 127 15 haploid haploid JJ cord-004862-yv76yvy5 127 16 genome genome NN cord-004862-yv76yvy5 127 17 of of IN cord-004862-yv76yvy5 127 18 the the DT cord-004862-yv76yvy5 127 19 rabbit rabbit NN cord-004862-yv76yvy5 127 20 , , , cord-004862-yv76yvy5 127 21 and and CC cord-004862-yv76yvy5 127 22 regions region NNS cord-004862-yv76yvy5 127 23 of of IN cord-004862-yv76yvy5 127 24 L1 L1 NNP cord-004862-yv76yvy5 127 25 located locate VBD cord-004862-yv76yvy5 127 26 more more JJR cord-004862-yv76yvy5 127 27 3 3 CD cord-004862-yv76yvy5 127 28 ' ' '' cord-004862-yv76yvy5 127 29 are be VBP cord-004862-yv76yvy5 127 30 found find VBN cord-004862-yv76yvy5 127 31 more more RBR cord-004862-yv76yvy5 127 32 frequently frequently RB cord-004862-yv76yvy5 127 33 . . . cord-004862-yv76yvy5 128 1 The the DT cord-004862-yv76yvy5 128 2 largest large JJS cord-004862-yv76yvy5 128 3 increase increase NN cord-004862-yv76yvy5 128 4 in in IN cord-004862-yv76yvy5 128 5 copy copy NN cord-004862-yv76yvy5 128 6 number number NN cord-004862-yv76yvy5 128 7 is be VBZ cord-004862-yv76yvy5 128 8 seen see VBN cord-004862-yv76yvy5 128 9 in in IN cord-004862-yv76yvy5 128 10 the the DT cord-004862-yv76yvy5 128 11 region region NN cord-004862-yv76yvy5 128 12 from from IN cord-004862-yv76yvy5 128 13 positions position NNS cord-004862-yv76yvy5 128 14 4351 4351 CD cord-004862-yv76yvy5 128 15 to to IN cord-004862-yv76yvy5 128 16 6004 6004 CD cord-004862-yv76yvy5 128 17 that that WDT cord-004862-yv76yvy5 128 18 includes include VBZ cord-004862-yv76yvy5 128 19 the the DT cord-004862-yv76yvy5 128 20 3 3 CD cord-004862-yv76yvy5 128 21 ' ' POS cord-004862-yv76yvy5 128 22 untranslated untranslated JJ cord-004862-yv76yvy5 128 23 region region NN cord-004862-yv76yvy5 128 24 ; ; : cord-004862-yv76yvy5 128 25 this this DT cord-004862-yv76yvy5 128 26 region region NN cord-004862-yv76yvy5 128 27 is be VBZ cord-004862-yv76yvy5 128 28 represented represent VBN cord-004862-yv76yvy5 128 29 at at IN cord-004862-yv76yvy5 128 30 least least RBS cord-004862-yv76yvy5 128 31 66,000 66,000 CD cord-004862-yv76yvy5 128 32 times time NNS cord-004862-yv76yvy5 128 33 . . . cord-004862-yv76yvy5 129 1 However however RB cord-004862-yv76yvy5 129 2 , , , cord-004862-yv76yvy5 129 3 the the DT cord-004862-yv76yvy5 129 4 relationship relationship NN cord-004862-yv76yvy5 129 5 between between IN cord-004862-yv76yvy5 129 6 the the DT cord-004862-yv76yvy5 129 7 length length NN cord-004862-yv76yvy5 129 8 of of IN cord-004862-yv76yvy5 129 9 the the DT cord-004862-yv76yvy5 129 10 repeat repeat NN cord-004862-yv76yvy5 129 11 and and CC cord-004862-yv76yvy5 129 12 the the DT cord-004862-yv76yvy5 129 13 copy copy NN cord-004862-yv76yvy5 129 14 number number NN cord-004862-yv76yvy5 129 15 is be VBZ cord-004862-yv76yvy5 129 16 not not RB cord-004862-yv76yvy5 129 17 linear linear JJ cord-004862-yv76yvy5 129 18 ; ; : cord-004862-yv76yvy5 129 19 only only RB cord-004862-yv76yvy5 129 20 a a DT cord-004862-yv76yvy5 129 21 gradual gradual JJ cord-004862-yv76yvy5 129 22 decrease decrease NN cord-004862-yv76yvy5 129 23 in in IN cord-004862-yv76yvy5 129 24 copy copy NN cord-004862-yv76yvy5 129 25 number number NN cord-004862-yv76yvy5 129 26 is be VBZ cord-004862-yv76yvy5 129 27 observed observe VBN cord-004862-yv76yvy5 129 28 as as IN cord-004862-yv76yvy5 129 29 probes probe NNS cord-004862-yv76yvy5 129 30 going go VBG cord-004862-yv76yvy5 129 31 from from IN cord-004862-yv76yvy5 129 32 position position NN cord-004862-yv76yvy5 129 33 4350 4350 CD cord-004862-yv76yvy5 129 34 to to TO cord-004862-yv76yvy5 129 35 position position VB cord-004862-yv76yvy5 129 36 1 1 CD cord-004862-yv76yvy5 129 37 are be VBP cord-004862-yv76yvy5 129 38 used use VBN cord-004862-yv76yvy5 129 39 ( ( -LRB- cord-004862-yv76yvy5 129 40 Fig Fig NNP cord-004862-yv76yvy5 129 41 . . . cord-004862-yv76yvy5 129 42 4 4 CD cord-004862-yv76yvy5 129 43 ) ) -RRB- cord-004862-yv76yvy5 129 44 . . . cord-004862-yv76yvy5 130 1 Therefore therefore RB cord-004862-yv76yvy5 130 2 , , , cord-004862-yv76yvy5 130 3 many many JJ cord-004862-yv76yvy5 130 4 of of IN cord-004862-yv76yvy5 130 5 the the DT cord-004862-yv76yvy5 130 6 L1 L1 NNP cord-004862-yv76yvy5 130 7 repeats repeat NNS cord-004862-yv76yvy5 130 8 detected detect VBN cord-004862-yv76yvy5 130 9 with with IN cord-004862-yv76yvy5 130 10 the the DT cord-004862-yv76yvy5 130 11 probe probe NN cord-004862-yv76yvy5 130 12 from from IN cord-004862-yv76yvy5 130 13 the the DT cord-004862-yv76yvy5 130 14 5 5 CD cord-004862-yv76yvy5 130 15 ' ' NN cord-004862-yv76yvy5 130 16 end end NN cord-004862-yv76yvy5 130 17 may may MD cord-004862-yv76yvy5 130 18 be be VB cord-004862-yv76yvy5 130 19 full full JJ cord-004862-yv76yvy5 130 20 length length NN cord-004862-yv76yvy5 130 21 , , , cord-004862-yv76yvy5 130 22 indicating indicate VBG cord-004862-yv76yvy5 130 23 that that IN cord-004862-yv76yvy5 130 24 up up IN cord-004862-yv76yvy5 130 25 to to TO cord-004862-yv76yvy5 130 26 17 17 CD cord-004862-yv76yvy5 130 27 % % NN cord-004862-yv76yvy5 130 28 of of IN cord-004862-yv76yvy5 130 29 the the DT cord-004862-yv76yvy5 130 30 population population NN cord-004862-yv76yvy5 130 31 of of IN cord-004862-yv76yvy5 130 32 LIOc LIOc NNP cord-004862-yv76yvy5 130 33 repeats repeat NNS cord-004862-yv76yvy5 130 34 could could MD cord-004862-yv76yvy5 130 35 be be VB cord-004862-yv76yvy5 130 36 full full JJ cord-004862-yv76yvy5 130 37 length length NN cord-004862-yv76yvy5 130 38 . . . cord-004862-yv76yvy5 131 1 This this DT cord-004862-yv76yvy5 131 2 difference difference NN cord-004862-yv76yvy5 131 3 in in IN cord-004862-yv76yvy5 131 4 copy copy NN cord-004862-yv76yvy5 131 5 number number NN cord-004862-yv76yvy5 131 6 at at IN cord-004862-yv76yvy5 131 7 the the DT cord-004862-yv76yvy5 131 8 5 5 CD cord-004862-yv76yvy5 131 9 ' ' '' cord-004862-yv76yvy5 131 10 and and CC cord-004862-yv76yvy5 131 11 3 3 CD cord-004862-yv76yvy5 131 12 ' ' POS cord-004862-yv76yvy5 131 13 ends end NNS cord-004862-yv76yvy5 131 14 of of IN cord-004862-yv76yvy5 131 15 LIOc LIOc NNP cord-004862-yv76yvy5 131 16 repeats repeat VBZ cord-004862-yv76yvy5 131 17 is be VBZ cord-004862-yv76yvy5 131 18 also also RB cord-004862-yv76yvy5 131 19 observed observe VBN cord-004862-yv76yvy5 131 20 when when WRB cord-004862-yv76yvy5 131 21 uncloned uncloned JJ cord-004862-yv76yvy5 131 22 genomic genomic JJ cord-004862-yv76yvy5 131 23 DNA dna NN cord-004862-yv76yvy5 131 24 is be VBZ cord-004862-yv76yvy5 131 25 hybridized hybridize VBN cord-004862-yv76yvy5 131 26 with with IN cord-004862-yv76yvy5 131 27 the the DT cord-004862-yv76yvy5 131 28 different different JJ cord-004862-yv76yvy5 131 29 L1Oc L1Oc NNP cord-004862-yv76yvy5 131 30 probes probe NNS cord-004862-yv76yvy5 131 31 ( ( -LRB- cord-004862-yv76yvy5 131 32 data datum NNS cord-004862-yv76yvy5 131 33 not not RB cord-004862-yv76yvy5 131 34 shown show VBN cord-004862-yv76yvy5 131 35 ) ) -RRB- cord-004862-yv76yvy5 131 36 . . . cord-004862-yv76yvy5 132 1 Thus thus RB cord-004862-yv76yvy5 132 2 , , , cord-004862-yv76yvy5 132 3 the the DT cord-004862-yv76yvy5 132 4 lower low JJR cord-004862-yv76yvy5 132 5 copy copy NN cord-004862-yv76yvy5 132 6 number number NN cord-004862-yv76yvy5 132 7 at at IN cord-004862-yv76yvy5 132 8 the the DT cord-004862-yv76yvy5 132 9 5 5 CD cord-004862-yv76yvy5 132 10 ' ' NN cord-004862-yv76yvy5 132 11 end end NN cord-004862-yv76yvy5 132 12 is be VBZ cord-004862-yv76yvy5 132 13 not not RB cord-004862-yv76yvy5 132 14 a a DT cord-004862-yv76yvy5 132 15 result result NN cord-004862-yv76yvy5 132 16 of of IN cord-004862-yv76yvy5 132 17 underrepresenration underrepresenration NN cord-004862-yv76yvy5 132 18 in in IN cord-004862-yv76yvy5 132 19 the the DT cord-004862-yv76yvy5 132 20 cloned clone VBN cord-004862-yv76yvy5 132 21 genomic genomic JJ cord-004862-yv76yvy5 132 22 library library NN cord-004862-yv76yvy5 132 23 . . . cord-004862-yv76yvy5 133 1 Because because IN cord-004862-yv76yvy5 133 2 the the DT cord-004862-yv76yvy5 133 3 5 5 CD cord-004862-yv76yvy5 133 4 ' ' NN cord-004862-yv76yvy5 133 5 end end NN cord-004862-yv76yvy5 133 6 of of IN cord-004862-yv76yvy5 133 7 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 133 8 is be VBZ cord-004862-yv76yvy5 133 9 at at IN cord-004862-yv76yvy5 133 10 the the DT cord-004862-yv76yvy5 133 11 end end NN cord-004862-yv76yvy5 133 12 of of IN cord-004862-yv76yvy5 133 13 the the DT cord-004862-yv76yvy5 133 14 cloned clone VBN cord-004862-yv76yvy5 133 15 portion portion NN cord-004862-yv76yvy5 133 16 of of IN cord-004862-yv76yvy5 133 17 the the DT cord-004862-yv76yvy5 133 18 rabbit/3 rabbit/3 JJ cord-004862-yv76yvy5 133 19 - - HYPH cord-004862-yv76yvy5 133 20 1ike 1ike CD cord-004862-yv76yvy5 133 21 globin globin NN cord-004862-yv76yvy5 133 22 gene gene NN cord-004862-yv76yvy5 133 23 cluster cluster NN cord-004862-yv76yvy5 133 24 , , , cord-004862-yv76yvy5 133 25 it -PRON- PRP cord-004862-yv76yvy5 133 26 is be VBZ cord-004862-yv76yvy5 133 27 likely likely JJ cord-004862-yv76yvy5 133 28 that that IN cord-004862-yv76yvy5 133 29 the the DT cord-004862-yv76yvy5 133 30 nucleotide nucleotide JJ cord-004862-yv76yvy5 133 31 sequence sequence NN cord-004862-yv76yvy5 133 32 obtained obtain VBN cord-004862-yv76yvy5 133 33 from from IN cord-004862-yv76yvy5 133 34 L1Oc5 L1Oc5 NNP cord-004862-yv76yvy5 133 35 is be VBZ cord-004862-yv76yvy5 133 36 not not RB cord-004862-yv76yvy5 133 37 that that DT cord-004862-yv76yvy5 133 38 of of IN cord-004862-yv76yvy5 133 39 a a DT cord-004862-yv76yvy5 133 40 full full JJ cord-004862-yv76yvy5 133 41 - - HYPH cord-004862-yv76yvy5 133 42 length length NN cord-004862-yv76yvy5 133 43 L1 L1 NNP cord-004862-yv76yvy5 133 44 repeat repeat NN cord-004862-yv76yvy5 133 45 . . . cord-004862-yv76yvy5 134 1 Therefore therefore RB cord-004862-yv76yvy5 134 2 , , , cord-004862-yv76yvy5 134 3 cloned clone VBN cord-004862-yv76yvy5 134 4 subfragments subfragment NNS cord-004862-yv76yvy5 134 5 of of IN cord-004862-yv76yvy5 134 6 L L NNP cord-004862-yv76yvy5 134 7 1 1 CD cord-004862-yv76yvy5 134 8 Oc5 oc5 NN cord-004862-yv76yvy5 134 9 were be VBD cord-004862-yv76yvy5 134 10 used use VBN cord-004862-yv76yvy5 134 11 as as IN cord-004862-yv76yvy5 134 12 probes probe NNS cord-004862-yv76yvy5 134 13 against against IN cord-004862-yv76yvy5 134 14 Southern Southern NNP cord-004862-yv76yvy5 134 15 ( ( -LRB- cord-004862-yv76yvy5 134 16 1975 1975 CD cord-004862-yv76yvy5 134 17 ) ) -RRB- cord-004862-yv76yvy5 134 18 blots blot NNS cord-004862-yv76yvy5 134 19 of of IN cord-004862-yv76yvy5 134 20 rabbit rabbit NN cord-004862-yv76yvy5 134 21 genomic genomic JJ cord-004862-yv76yvy5 134 22 DNA dna NN cord-004862-yv76yvy5 134 23 to to TO cord-004862-yv76yvy5 134 24 determine determine VB cord-004862-yv76yvy5 134 25 the the DT cord-004862-yv76yvy5 134 26 average average JJ cord-004862-yv76yvy5 134 27 structure structure NN cord-004862-yv76yvy5 134 28 of of IN cord-004862-yv76yvy5 134 29 full full JJ cord-004862-yv76yvy5 134 30 - - HYPH cord-004862-yv76yvy5 134 31 length length NN cord-004862-yv76yvy5 134 32 rabbit rabbit NN cord-004862-yv76yvy5 134 33 L1 L1 NNP cord-004862-yv76yvy5 134 34 repeats repeat VBZ cord-004862-yv76yvy5 134 35 . . . cord-004862-yv76yvy5 135 1 Discrete discrete JJ cord-004862-yv76yvy5 135 2 genomic genomic JJ cord-004862-yv76yvy5 135 3 restriction restriction NN cord-004862-yv76yvy5 135 4 fragments fragment NNS cord-004862-yv76yvy5 135 5 detected detect VBN cord-004862-yv76yvy5 135 6 with with IN cord-004862-yv76yvy5 135 7 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 135 8 probes probe NNS cord-004862-yv76yvy5 135 9 were be VBD cord-004862-yv76yvy5 135 10 mapped map VBN cord-004862-yv76yvy5 135 11 by by IN cord-004862-yv76yvy5 135 12 two two CD cord-004862-yv76yvy5 135 13 strategies strategy NNS cord-004862-yv76yvy5 135 14 . . . cord-004862-yv76yvy5 136 1 The the DT cord-004862-yv76yvy5 136 2 portion portion NN cord-004862-yv76yvy5 136 3 of of IN cord-004862-yv76yvy5 136 4 L L NNP cord-004862-yv76yvy5 136 5 1 1 CD cord-004862-yv76yvy5 136 6 Oc Oc NNP cord-004862-yv76yvy5 136 7 contained contain VBD cord-004862-yv76yvy5 136 8 within within IN cord-004862-yv76yvy5 136 9 the the DT cord-004862-yv76yvy5 136 10 genomic genomic JJ cord-004862-yv76yvy5 136 11 restriction restriction NN cord-004862-yv76yvy5 136 12 fragment fragment NN cord-004862-yv76yvy5 136 13 was be VBD cord-004862-yv76yvy5 136 14 determined determine VBN cord-004862-yv76yvy5 136 15 by by IN cord-004862-yv76yvy5 136 16 which which WDT cord-004862-yv76yvy5 136 17 probes probe NNS cord-004862-yv76yvy5 136 18 from from IN cord-004862-yv76yvy5 136 19 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 136 20 hybridized hybridize VBN cord-004862-yv76yvy5 136 21 to to IN cord-004862-yv76yvy5 136 22 the the DT cord-004862-yv76yvy5 136 23 fragment fragment NN cord-004862-yv76yvy5 136 24 , , , cord-004862-yv76yvy5 136 25 and and CC cord-004862-yv76yvy5 136 26 then then RB cord-004862-yv76yvy5 136 27 the the DT cord-004862-yv76yvy5 136 28 genomic genomic JJ cord-004862-yv76yvy5 136 29 restriction restriction NN cord-004862-yv76yvy5 136 30 fragment fragment NN cord-004862-yv76yvy5 136 31 was be VBD cord-004862-yv76yvy5 136 32 aligned align VBN cord-004862-yv76yvy5 136 33 with with IN cord-004862-yv76yvy5 136 34 conserved conserved JJ cord-004862-yv76yvy5 136 35 restriction restriction NN cord-004862-yv76yvy5 136 36 sites site NNS cord-004862-yv76yvy5 136 37 found find VBN cord-004862-yv76yvy5 136 38 in in IN cord-004862-yv76yvy5 136 39 the the DT cord-004862-yv76yvy5 136 40 cloned clone VBN cord-004862-yv76yvy5 136 41 LI LI NNP cord-004862-yv76yvy5 136 42 Oc Oc NNP cord-004862-yv76yvy5 136 43 DNA DNA NNP cord-004862-yv76yvy5 136 44 . . . cord-004862-yv76yvy5 137 1 This this DT cord-004862-yv76yvy5 137 2 analysis analysis NN cord-004862-yv76yvy5 137 3 is be VBZ cord-004862-yv76yvy5 137 4 presented present VBN cord-004862-yv76yvy5 137 5 in in IN cord-004862-yv76yvy5 137 6 detail detail NN cord-004862-yv76yvy5 137 7 in in IN cord-004862-yv76yvy5 137 8 Demers Demers NNP cord-004862-yv76yvy5 137 9 ( ( -LRB- cord-004862-yv76yvy5 137 10 1987 1987 CD cord-004862-yv76yvy5 137 11 ) ) -RRB- cord-004862-yv76yvy5 137 12 , , , cord-004862-yv76yvy5 137 13 and and CC cord-004862-yv76yvy5 137 14 the the DT cord-004862-yv76yvy5 137 15 portion portion NN cord-004862-yv76yvy5 137 16 relevant relevant JJ cord-004862-yv76yvy5 137 17 to to IN cord-004862-yv76yvy5 137 18 the the DT cord-004862-yv76yvy5 137 19 5 5 CD cord-004862-yv76yvy5 137 20 ' ' NN cord-004862-yv76yvy5 137 21 end end NN cord-004862-yv76yvy5 137 22 of of IN cord-004862-yv76yvy5 137 23 L1Oc L1Oc NNP cord-004862-yv76yvy5 137 24 is be VBZ cord-004862-yv76yvy5 137 25 summarized summarize VBN cord-004862-yv76yvy5 137 26 in in IN cord-004862-yv76yvy5 137 27 Fig Fig NNP cord-004862-yv76yvy5 137 28 Seal Seal NNP cord-004862-yv76yvy5 137 29 2.1 2.1 CD cord-004862-yv76yvy5 137 30 Sphl Sphl NNP cord-004862-yv76yvy5 137 31 1.9 1.9 CD cord-004862-yv76yvy5 137 32 Xmnl Xmnl NNP cord-004862-yv76yvy5 137 33 3.7 3.7 CD cord-004862-yv76yvy5 137 34 The the DT cord-004862-yv76yvy5 137 35 longest long JJS cord-004862-yv76yvy5 137 36 restriction restriction NN cord-004862-yv76yvy5 137 37 fragment fragment NN cord-004862-yv76yvy5 137 38 extending extend VBG cord-004862-yv76yvy5 137 39 5 5 CD cord-004862-yv76yvy5 137 40 ' ' '' cord-004862-yv76yvy5 137 41 to to IN cord-004862-yv76yvy5 137 42 the the DT cord-004862-yv76yvy5 137 43 cloned clone VBN cord-004862-yv76yvy5 137 44 end end NN cord-004862-yv76yvy5 137 45 of of IN cord-004862-yv76yvy5 137 46 L l NN cord-004862-yv76yvy5 137 47 1 1 CD cord-004862-yv76yvy5 137 48 Oc5 oc5 NN cord-004862-yv76yvy5 137 49 is be VBZ cord-004862-yv76yvy5 137 50 the the DT cord-004862-yv76yvy5 137 51 PstI PstI NNP cord-004862-yv76yvy5 137 52 4.0-kb 4.0-kb CD cord-004862-yv76yvy5 137 53 fragment fragment NN cord-004862-yv76yvy5 137 54 that that WDT cord-004862-yv76yvy5 137 55 ends end VBZ cord-004862-yv76yvy5 137 56 1 1 CD cord-004862-yv76yvy5 137 57 kb kb NNP cord-004862-yv76yvy5 137 58 5 5 CD cord-004862-yv76yvy5 137 59 ' ' '' cord-004862-yv76yvy5 137 60 to to IN cord-004862-yv76yvy5 137 61 the the DT cord-004862-yv76yvy5 137 62 cloned clone VBN cord-004862-yv76yvy5 137 63 region region NN cord-004862-yv76yvy5 137 64 of of IN cord-004862-yv76yvy5 137 65 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 137 66 ( ( -LRB- cord-004862-yv76yvy5 137 67 Fig fig NN cord-004862-yv76yvy5 137 68 . . . cord-004862-yv76yvy5 137 69 _SP cord-004862-yv76yvy5 137 70 5 5 CD cord-004862-yv76yvy5 137 71 ) ) -RRB- cord-004862-yv76yvy5 137 72 . . . cord-004862-yv76yvy5 138 1 The the DT cord-004862-yv76yvy5 138 2 ScaI ScaI NNP cord-004862-yv76yvy5 138 3 2.1-kb 2.1-kb CD cord-004862-yv76yvy5 138 4 , , , cord-004862-yv76yvy5 138 5 SphI SphI NNP cord-004862-yv76yvy5 138 6 1.9-kb 1.9-kb CD cord-004862-yv76yvy5 138 7 , , , cord-004862-yv76yvy5 138 8 and and CC cord-004862-yv76yvy5 138 9 XmnI XmnI NNP cord-004862-yv76yvy5 138 10 3.7-kb 3.7-kb CD cord-004862-yv76yvy5 138 11 genomic genomic JJ cord-004862-yv76yvy5 138 12 fragments fragment NNS cord-004862-yv76yvy5 138 13 all all DT cord-004862-yv76yvy5 138 14 have have VBP cord-004862-yv76yvy5 138 15 5 5 CD cord-004862-yv76yvy5 138 16 ' ' '' cord-004862-yv76yvy5 138 17 ends end NNS cord-004862-yv76yvy5 138 18 between between IN cord-004862-yv76yvy5 138 19 the the DT cord-004862-yv76yvy5 138 20 conserved conserve VBN cord-004862-yv76yvy5 138 21 PstI PstI NNP cord-004862-yv76yvy5 138 22 site site NN cord-004862-yv76yvy5 138 23 located locate VBN cord-004862-yv76yvy5 138 24 outside outside IN cord-004862-yv76yvy5 138 25 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 138 26 and and CC cord-004862-yv76yvy5 138 27 the the DT cord-004862-yv76yvy5 138 28 5 5 CD cord-004862-yv76yvy5 138 29 ' ' NN cord-004862-yv76yvy5 138 30 end end NN cord-004862-yv76yvy5 138 31 of of IN cord-004862-yv76yvy5 138 32 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 138 33 ( ( -LRB- cord-004862-yv76yvy5 138 34 Fig fig NN cord-004862-yv76yvy5 138 35 . . . cord-004862-yv76yvy5 138 36 5 5 CD cord-004862-yv76yvy5 138 37 ) ) -RRB- cord-004862-yv76yvy5 138 38 . . . cord-004862-yv76yvy5 139 1 These these DT cord-004862-yv76yvy5 139 2 data datum NNS cord-004862-yv76yvy5 139 3 indicate indicate VBP cord-004862-yv76yvy5 139 4 that that IN cord-004862-yv76yvy5 139 5 fulllength fulllength NN cord-004862-yv76yvy5 139 6 L1Oc L1Oc NNP cord-004862-yv76yvy5 139 7 repeats repeat VBZ cord-004862-yv76yvy5 139 8 wiI1 wii1 NN cord-004862-yv76yvy5 139 9 extend extend VBP cord-004862-yv76yvy5 139 10 at at IN cord-004862-yv76yvy5 139 11 least least JJS cord-004862-yv76yvy5 139 12 1 1 CD cord-004862-yv76yvy5 139 13 kb kb NNP cord-004862-yv76yvy5 139 14 further further RB cord-004862-yv76yvy5 139 15 5 5 CD cord-004862-yv76yvy5 139 16 ' ' '' cord-004862-yv76yvy5 139 17 than than IN cord-004862-yv76yvy5 139 18 the the DT cord-004862-yv76yvy5 139 19 sequenced sequence VBN cord-004862-yv76yvy5 139 20 portion portion NN cord-004862-yv76yvy5 139 21 of of IN cord-004862-yv76yvy5 139 22 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 139 23 . . . cord-004862-yv76yvy5 140 1 Several several JJ cord-004862-yv76yvy5 140 2 clones clone NNS cord-004862-yv76yvy5 140 3 from from IN cord-004862-yv76yvy5 140 4 the the DT cord-004862-yv76yvy5 140 5 rabbit rabbit NN cord-004862-yv76yvy5 140 6 genomic genomic JJ cord-004862-yv76yvy5 140 7 DNA dna NN cord-004862-yv76yvy5 140 8 library library NN cord-004862-yv76yvy5 140 9 are be VBP cord-004862-yv76yvy5 140 10 currently currently RB cord-004862-yv76yvy5 140 11 being be VBG cord-004862-yv76yvy5 140 12 studied study VBN cord-004862-yv76yvy5 140 13 in in IN cord-004862-yv76yvy5 140 14 order order NN cord-004862-yv76yvy5 140 15 to to TO cord-004862-yv76yvy5 140 16 determine determine VB cord-004862-yv76yvy5 140 17 the the DT cord-004862-yv76yvy5 140 18 5 5 CD cord-004862-yv76yvy5 140 19 ' ' NN cord-004862-yv76yvy5 140 20 end end NN cord-004862-yv76yvy5 140 21 of of IN cord-004862-yv76yvy5 140 22 L1Oc L1Oc NNP cord-004862-yv76yvy5 140 23 repeats repeat VBZ cord-004862-yv76yvy5 140 24 . . . cord-004862-yv76yvy5 141 1 The the DT cord-004862-yv76yvy5 141 2 sequence sequence NN cord-004862-yv76yvy5 141 3 of of IN cord-004862-yv76yvy5 141 4 the the DT cord-004862-yv76yvy5 141 5 rabbit rabbit NN cord-004862-yv76yvy5 141 6 L1 L1 NNP cord-004862-yv76yvy5 141 7 repeat repeat NN cord-004862-yv76yvy5 141 8 was be VBD cord-004862-yv76yvy5 141 9 compared compare VBN cord-004862-yv76yvy5 141 10 with with IN cord-004862-yv76yvy5 141 11 the the DT cord-004862-yv76yvy5 141 12 sequences sequence NNS cord-004862-yv76yvy5 141 13 of of IN cord-004862-yv76yvy5 141 14 the the DT cord-004862-yv76yvy5 141 15 mouse mouse NN cord-004862-yv76yvy5 141 16 and and CC cord-004862-yv76yvy5 141 17 human human NN cord-004862-yv76yvy5 141 18 LI LI NNP cord-004862-yv76yvy5 142 1 repeats repeat NNS cord-004862-yv76yvy5 142 2 by by IN cord-004862-yv76yvy5 142 3 dot dot NN cord-004862-yv76yvy5 142 4 - - HYPH cord-004862-yv76yvy5 142 5 plots plot NNS cord-004862-yv76yvy5 142 6 and and CC cord-004862-yv76yvy5 142 7 by by IN cord-004862-yv76yvy5 142 8 sequence sequence NN cord-004862-yv76yvy5 142 9 alignments alignment NNS cord-004862-yv76yvy5 142 10 . . . cord-004862-yv76yvy5 143 1 The the DT cord-004862-yv76yvy5 143 2 dot dot NN cord-004862-yv76yvy5 143 3 - - HYPH cord-004862-yv76yvy5 143 4 plot plot NN cord-004862-yv76yvy5 143 5 analyses analysis NNS cord-004862-yv76yvy5 143 6 in in IN cord-004862-yv76yvy5 143 7 Fig Fig NNP cord-004862-yv76yvy5 143 8 . . . cord-004862-yv76yvy5 144 1 6 6 CD cord-004862-yv76yvy5 144 2 show show VBP cord-004862-yv76yvy5 144 3 that that IN cord-004862-yv76yvy5 144 4 the the DT cord-004862-yv76yvy5 144 5 internal internal JJ cord-004862-yv76yvy5 144 6 sequence sequence NN cord-004862-yv76yvy5 144 7 of of IN cord-004862-yv76yvy5 144 8 L1Oc L1Oc NNP cord-004862-yv76yvy5 144 9 is be VBZ cord-004862-yv76yvy5 144 10 very very RB cord-004862-yv76yvy5 144 11 similar similar JJ cord-004862-yv76yvy5 144 12 to to IN cord-004862-yv76yvy5 144 13 both both DT cord-004862-yv76yvy5 144 14 L1Md L1Md NNPS cord-004862-yv76yvy5 144 15 ( ( -LRB- cord-004862-yv76yvy5 144 16 mouse mouse NN cord-004862-yv76yvy5 144 17 ) ) -RRB- cord-004862-yv76yvy5 144 18 and and CC cord-004862-yv76yvy5 144 19 L1Hs L1Hs NNP cord-004862-yv76yvy5 144 20 ( ( -LRB- cord-004862-yv76yvy5 144 21 human human NN cord-004862-yv76yvy5 144 22 ) ) -RRB- cord-004862-yv76yvy5 144 23 over over IN cord-004862-yv76yvy5 144 24 very very RB cord-004862-yv76yvy5 144 25 long long JJ cord-004862-yv76yvy5 144 26 segments segment NNS cord-004862-yv76yvy5 144 27 , , , cord-004862-yv76yvy5 144 28 whereas whereas IN cord-004862-yv76yvy5 144 29 the the DT cord-004862-yv76yvy5 144 30 5 5 CD cord-004862-yv76yvy5 144 31 ' ' '' cord-004862-yv76yvy5 144 32 and and CC cord-004862-yv76yvy5 144 33 3 3 CD cord-004862-yv76yvy5 144 34 ' ' POS cord-004862-yv76yvy5 144 35 ends end NNS cord-004862-yv76yvy5 144 36 are be VBP cord-004862-yv76yvy5 144 37 not not RB cord-004862-yv76yvy5 144 38 conserved conserve VBN cord-004862-yv76yvy5 144 39 between between IN cord-004862-yv76yvy5 144 40 species specie NNS cord-004862-yv76yvy5 144 41 . . . cord-004862-yv76yvy5 145 1 The the DT cord-004862-yv76yvy5 145 2 internal internal JJ cord-004862-yv76yvy5 145 3 region region NN cord-004862-yv76yvy5 145 4 of of IN cord-004862-yv76yvy5 145 5 sequence sequence NN cord-004862-yv76yvy5 145 6 similarity similarity NN cord-004862-yv76yvy5 145 7 of of IN cord-004862-yv76yvy5 145 8 about about IN cord-004862-yv76yvy5 145 9 4.5 4.5 CD cord-004862-yv76yvy5 145 10 kb kb NNP cord-004862-yv76yvy5 145 11 is be VBZ cord-004862-yv76yvy5 145 12 divided divide VBN cord-004862-yv76yvy5 145 13 into into IN cord-004862-yv76yvy5 145 14 two two CD cord-004862-yv76yvy5 145 15 pans pan NNS cord-004862-yv76yvy5 145 16 , , , cord-004862-yv76yvy5 145 17 a a DT cord-004862-yv76yvy5 145 18 short short JJ cord-004862-yv76yvy5 145 19 region region NN cord-004862-yv76yvy5 145 20 of of IN cord-004862-yv76yvy5 145 21 similarity similarity NN cord-004862-yv76yvy5 145 22 of of IN cord-004862-yv76yvy5 145 23 about about RB cord-004862-yv76yvy5 145 24 300 300 CD cord-004862-yv76yvy5 145 25 bp bp NNP cord-004862-yv76yvy5 145 26 followed follow VBN cord-004862-yv76yvy5 145 27 by by IN cord-004862-yv76yvy5 145 28 a a DT cord-004862-yv76yvy5 145 29 very very RB cord-004862-yv76yvy5 145 30 long long JJ cord-004862-yv76yvy5 145 31 segment segment NN cord-004862-yv76yvy5 145 32 of of IN cord-004862-yv76yvy5 145 33 similarity similarity NN cord-004862-yv76yvy5 145 34 . . . cord-004862-yv76yvy5 146 1 The the DT cord-004862-yv76yvy5 146 2 long long JJ cord-004862-yv76yvy5 146 3 segments segment NNS cord-004862-yv76yvy5 146 4 of of IN cord-004862-yv76yvy5 146 5 internal internal JJ cord-004862-yv76yvy5 146 6 similarity similarity NN cord-004862-yv76yvy5 146 7 are be VBP cord-004862-yv76yvy5 146 8 in in IN cord-004862-yv76yvy5 146 9 the the DT cord-004862-yv76yvy5 146 10 portion portion NN cord-004862-yv76yvy5 146 11 of of IN cord-004862-yv76yvy5 146 12 L l NN cord-004862-yv76yvy5 146 13 1 1 CD cord-004862-yv76yvy5 146 14 that that WDT cord-004862-yv76yvy5 146 15 encodes encode VBZ cord-004862-yv76yvy5 146 16 open open JJ cord-004862-yv76yvy5 146 17 reading reading NN cord-004862-yv76yvy5 146 18 frames frame NNS cord-004862-yv76yvy5 146 19 ( ( -LRB- cord-004862-yv76yvy5 146 20 ORFs ORFs NNP cord-004862-yv76yvy5 146 21 ) ) -RRB- cord-004862-yv76yvy5 146 22 . . . cord-004862-yv76yvy5 147 1 The the DT cord-004862-yv76yvy5 147 2 ORFs orfs NN cord-004862-yv76yvy5 147 3 found find VBD cord-004862-yv76yvy5 147 4 in in IN cord-004862-yv76yvy5 147 5 the the DT cord-004862-yv76yvy5 147 6 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 147 7 sequence sequence NN cord-004862-yv76yvy5 147 8 are be VBP cord-004862-yv76yvy5 147 9 shown show VBN cord-004862-yv76yvy5 147 10 in in IN cord-004862-yv76yvy5 147 11 Fig Fig NNP cord-004862-yv76yvy5 147 12 . . . cord-004862-yv76yvy5 148 1 7 7 CD cord-004862-yv76yvy5 148 2 , , , cord-004862-yv76yvy5 148 3 along along IN cord-004862-yv76yvy5 148 4 with with IN cord-004862-yv76yvy5 148 5 a a DT cord-004862-yv76yvy5 148 6 comparison comparison NN cord-004862-yv76yvy5 148 7 of of IN cord-004862-yv76yvy5 148 8 the the DT cord-004862-yv76yvy5 148 9 ORFs ORFs NNP cord-004862-yv76yvy5 148 10 from from IN cord-004862-yv76yvy5 148 11 L1Md L1Md NNP cord-004862-yv76yvy5 148 12 . . . cord-004862-yv76yvy5 149 1 The the DT cord-004862-yv76yvy5 149 2 mouse mouse NN cord-004862-yv76yvy5 149 3 LIMdA2 LIMdA2 NNP cord-004862-yv76yvy5 149 4 sequence sequence NN cord-004862-yv76yvy5 149 5 contains contain VBZ cord-004862-yv76yvy5 149 6 two two CD cord-004862-yv76yvy5 149 7 ORFs orf NNS cord-004862-yv76yvy5 149 8 , , , cord-004862-yv76yvy5 149 9 one one CD cord-004862-yv76yvy5 149 10 of of IN cord-004862-yv76yvy5 149 11 1137 1137 CD cord-004862-yv76yvy5 149 12 nucleotides nucleotide NNS cord-004862-yv76yvy5 149 13 ( ( -LRB- cord-004862-yv76yvy5 149 14 top top JJ cord-004862-yv76yvy5 149 15 strand strand NN cord-004862-yv76yvy5 149 16 , , , cord-004862-yv76yvy5 149 17 N n CD cord-004862-yv76yvy5 149 18 frame frame NN cord-004862-yv76yvy5 149 19 in in IN cord-004862-yv76yvy5 149 20 Fig Fig NNP cord-004862-yv76yvy5 149 21 . . NNP cord-004862-yv76yvy5 149 22 7 7 CD cord-004862-yv76yvy5 149 23 , , , cord-004862-yv76yvy5 149 24 bottom bottom JJ cord-004862-yv76yvy5 149 25 panel panel NN cord-004862-yv76yvy5 149 26 ) ) -RRB- cord-004862-yv76yvy5 149 27 and and CC cord-004862-yv76yvy5 149 28 one one CD cord-004862-yv76yvy5 149 29 of of IN cord-004862-yv76yvy5 149 30 3900 3900 CD cord-004862-yv76yvy5 149 31 nucleotides nucleotide NNS cord-004862-yv76yvy5 149 32 ( ( -LRB- cord-004862-yv76yvy5 149 33 top top JJ cord-004862-yv76yvy5 149 34 strand strand NN cord-004862-yv76yvy5 149 35 , , , cord-004862-yv76yvy5 149 36 N n NN cord-004862-yv76yvy5 149 37 + + SYM cord-004862-yv76yvy5 149 38 1 1 CD cord-004862-yv76yvy5 149 39 frame frame NN cord-004862-yv76yvy5 149 40 in in IN cord-004862-yv76yvy5 149 41 Fig Fig NNP cord-004862-yv76yvy5 149 42 . . . cord-004862-yv76yvy5 149 43 _SP cord-004862-yv76yvy5 150 1 7 7 LS cord-004862-yv76yvy5 150 2 ) ) -RRB- cord-004862-yv76yvy5 150 3 , , , cord-004862-yv76yvy5 150 4 that that WDT cord-004862-yv76yvy5 150 5 overlap overlap VBP cord-004862-yv76yvy5 150 6 by by IN cord-004862-yv76yvy5 150 7 14 14 CD cord-004862-yv76yvy5 150 8 nucleotides nucleotide NNS cord-004862-yv76yvy5 150 9 ) ) -RRB- cord-004862-yv76yvy5 150 10 . . . cord-004862-yv76yvy5 151 1 Seven seven CD cord-004862-yv76yvy5 151 2 open open JJ cord-004862-yv76yvy5 151 3 reading reading NN cord-004862-yv76yvy5 151 4 blocks block NNS cord-004862-yv76yvy5 151 5 are be VBP cord-004862-yv76yvy5 151 6 in in IN cord-004862-yv76yvy5 151 7 the the DT cord-004862-yv76yvy5 151 8 rabbit rabbit NN cord-004862-yv76yvy5 151 9 L1Oc5 l1oc5 NN cord-004862-yv76yvy5 151 10 sequence sequence NN cord-004862-yv76yvy5 151 11 in in IN cord-004862-yv76yvy5 151 12 frames frame NNS cord-004862-yv76yvy5 151 13 N N NNP cord-004862-yv76yvy5 151 14 , , , cord-004862-yv76yvy5 151 15 N n CD cord-004862-yv76yvy5 151 16 + + SYM cord-004862-yv76yvy5 151 17 1 1 CD cord-004862-yv76yvy5 151 18 , , , cord-004862-yv76yvy5 151 19 and and CC cord-004862-yv76yvy5 152 1 N n NN cord-004862-yv76yvy5 152 2 + + SYM cord-004862-yv76yvy5 152 3 2 2 CD cord-004862-yv76yvy5 152 4 ( ( -LRB- cord-004862-yv76yvy5 152 5 Fig Fig NNP cord-004862-yv76yvy5 152 6 . . NNP cord-004862-yv76yvy5 152 7 7 7 CD cord-004862-yv76yvy5 152 8 , , , cord-004862-yv76yvy5 152 9 top top JJ cord-004862-yv76yvy5 152 10 panel panel NN cord-004862-yv76yvy5 152 11 ) ) -RRB- cord-004862-yv76yvy5 152 12 . . . cord-004862-yv76yvy5 153 1 The the DT cord-004862-yv76yvy5 153 2 bar bar NN cord-004862-yv76yvy5 153 3 between between IN cord-004862-yv76yvy5 153 4 the the DT cord-004862-yv76yvy5 153 5 stop stop NN cord-004862-yv76yvy5 153 6 codon codon NN cord-004862-yv76yvy5 153 7 maps map NNS cord-004862-yv76yvy5 153 8 of of IN cord-004862-yv76yvy5 153 9 each each DT cord-004862-yv76yvy5 153 10 species specie NNS cord-004862-yv76yvy5 153 11 shows show VBZ cord-004862-yv76yvy5 153 12 the the DT cord-004862-yv76yvy5 153 13 regions region NNS cord-004862-yv76yvy5 153 14 of of IN cord-004862-yv76yvy5 153 15 similarity similarity NN cord-004862-yv76yvy5 153 16 ( ( -LRB- cord-004862-yv76yvy5 153 17 Fig Fig NNP cord-004862-yv76yvy5 153 18 . . . cord-004862-yv76yvy5 153 19 _SP cord-004862-yv76yvy5 153 20 6 6 CD cord-004862-yv76yvy5 153 21 ) ) -RRB- cord-004862-yv76yvy5 153 22 as as IN cord-004862-yv76yvy5 153 23 filled fill VBN cord-004862-yv76yvy5 153 24 boxes box NNS cord-004862-yv76yvy5 153 25 . . . cord-004862-yv76yvy5 154 1 It -PRON- PRP cord-004862-yv76yvy5 154 2 is be VBZ cord-004862-yv76yvy5 154 3 apparent apparent JJ cord-004862-yv76yvy5 154 4 that that IN cord-004862-yv76yvy5 154 5 the the DT cord-004862-yv76yvy5 154 6 regions region NNS cord-004862-yv76yvy5 154 7 of of IN cord-004862-yv76yvy5 154 8 L1 L1 NNP cord-004862-yv76yvy5 154 9 that that WDT cord-004862-yv76yvy5 154 10 are be VBP cord-004862-yv76yvy5 154 11 similar similar JJ cord-004862-yv76yvy5 154 12 between between IN cord-004862-yv76yvy5 154 13 species specie NNS cord-004862-yv76yvy5 154 14 contain contain VBP cord-004862-yv76yvy5 154 15 extensive extensive JJ cord-004862-yv76yvy5 154 16 ORFs orfs NN cord-004862-yv76yvy5 154 17 , , , cord-004862-yv76yvy5 154 18 although although IN cord-004862-yv76yvy5 154 19 the the DT cord-004862-yv76yvy5 154 20 ORFs ORFs NNP cord-004862-yv76yvy5 154 21 at at IN cord-004862-yv76yvy5 154 22 the the DT cord-004862-yv76yvy5 154 23 5 5 CD cord-004862-yv76yvy5 154 24 ' ' NN cord-004862-yv76yvy5 154 25 end end NN cord-004862-yv76yvy5 154 26 are be VBP cord-004862-yv76yvy5 154 27 not not RB cord-004862-yv76yvy5 154 28 similar similar JJ cord-004862-yv76yvy5 154 29 between between IN cord-004862-yv76yvy5 154 30 species specie NNS cord-004862-yv76yvy5 154 31 . . . cord-004862-yv76yvy5 155 1 Rabbit Rabbit NNP cord-004862-yv76yvy5 155 2 L1 L1 NNP cord-004862-yv76yvy5 155 3 repeats repeat NNS cord-004862-yv76yvy5 155 4 have have VBP cord-004862-yv76yvy5 155 5 only only RB cord-004862-yv76yvy5 155 6 two two CD cord-004862-yv76yvy5 155 7 major major JJ cord-004862-yv76yvy5 155 8 ORFs orfs NN cord-004862-yv76yvy5 155 9 . . . cord-004862-yv76yvy5 156 1 Although although IN cord-004862-yv76yvy5 156 2 the the DT cord-004862-yv76yvy5 156 3 data datum NNS cord-004862-yv76yvy5 156 4 in in IN cord-004862-yv76yvy5 156 5 Fig Fig NNP cord-004862-yv76yvy5 156 6 . . . cord-004862-yv76yvy5 156 7 7 7 CD cord-004862-yv76yvy5 156 8 show show VBP cord-004862-yv76yvy5 156 9 that that IN cord-004862-yv76yvy5 156 10 L1Oc5 L1Oc5 NNP cord-004862-yv76yvy5 156 11 has have VBZ cord-004862-yv76yvy5 156 12 several several JJ cord-004862-yv76yvy5 156 13 ORFs orf NNS cord-004862-yv76yvy5 156 14 , , , cord-004862-yv76yvy5 156 15 they -PRON- PRP cord-004862-yv76yvy5 156 16 are be VBP cord-004862-yv76yvy5 156 17 probably probably RB cord-004862-yv76yvy5 156 18 derived derive VBN cord-004862-yv76yvy5 156 19 from from IN cord-004862-yv76yvy5 156 20 longer long JJR cord-004862-yv76yvy5 156 21 reading read VBG cord-004862-yv76yvy5 156 22 frames frame NNS cord-004862-yv76yvy5 156 23 in in IN cord-004862-yv76yvy5 156 24 the the DT cord-004862-yv76yvy5 156 25 ancestral ancestral JJ cord-004862-yv76yvy5 156 26 L1 L1 NNP cord-004862-yv76yvy5 156 27 sequence sequence NN cord-004862-yv76yvy5 156 28 . . . cord-004862-yv76yvy5 157 1 The the DT cord-004862-yv76yvy5 157 2 Fig Fig NNP cord-004862-yv76yvy5 157 3 . . NNP cord-004862-yv76yvy5 157 4 9 9 CD cord-004862-yv76yvy5 157 5 . . . cord-004862-yv76yvy5 158 1 Sequence sequence NN cord-004862-yv76yvy5 158 2 similarities similarity NNS cord-004862-yv76yvy5 158 3 in in IN cord-004862-yv76yvy5 158 4 the the DT cord-004862-yv76yvy5 158 5 ORF- ORF- NNP cord-004862-yv76yvy5 158 6 ! ! . cord-004862-yv76yvy5 158 7 region region NN cord-004862-yv76yvy5 158 8 . . . cord-004862-yv76yvy5 159 1 The the DT cord-004862-yv76yvy5 159 2 L]Oc L]Oc NNP cord-004862-yv76yvy5 159 3 ORF ORF NNP cord-004862-yv76yvy5 159 4 - - : cord-004862-yv76yvy5 159 5 I I NNP cord-004862-yv76yvy5 159 6 region region NN cord-004862-yv76yvy5 159 7 is be VBZ cord-004862-yv76yvy5 159 8 shown show VBN cord-004862-yv76yvy5 159 9 as as IN cord-004862-yv76yvy5 159 10 a a DT cord-004862-yv76yvy5 159 11 black black JJ cord-004862-yv76yvy5 159 12 box box NN cord-004862-yv76yvy5 159 13 , , , cord-004862-yv76yvy5 159 14 numbered number VBN cord-004862-yv76yvy5 159 15 according accord VBG cord-004862-yv76yvy5 159 16 to to IN cord-004862-yv76yvy5 159 17 the the DT cord-004862-yv76yvy5 159 18 codon codon NN cord-004862-yv76yvy5 159 19 positions position NNS cord-004862-yv76yvy5 159 20 in in IN cord-004862-yv76yvy5 159 21 Fig Fig NNP cord-004862-yv76yvy5 159 22 . . . cord-004862-yv76yvy5 160 1 8 8 CD cord-004862-yv76yvy5 160 2 . . . cord-004862-yv76yvy5 161 1 The the DT cord-004862-yv76yvy5 161 2 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 161 3 regions region NNS cord-004862-yv76yvy5 161 4 from from IN cord-004862-yv76yvy5 161 5 L1Md L1Md NNP cord-004862-yv76yvy5 161 6 and and CC cord-004862-yv76yvy5 161 7 L L NNP cord-004862-yv76yvy5 161 8 1Hs 1h NNS cord-004862-yv76yvy5 161 9 are be VBP cord-004862-yv76yvy5 161 10 displayed display VBN cord-004862-yv76yvy5 161 11 as as IN cord-004862-yv76yvy5 161 12 composite composite JJ cord-004862-yv76yvy5 161 13 boxes box NNS cord-004862-yv76yvy5 161 14 . . . cord-004862-yv76yvy5 162 1 The the DT cord-004862-yv76yvy5 162 2 darkness darkness NN cord-004862-yv76yvy5 162 3 of of IN cord-004862-yv76yvy5 162 4 the the DT cord-004862-yv76yvy5 162 5 fill fill NN cord-004862-yv76yvy5 162 6 in in IN cord-004862-yv76yvy5 162 7 each each DT cord-004862-yv76yvy5 162 8 box box NN cord-004862-yv76yvy5 162 9 is be VBZ cord-004862-yv76yvy5 162 10 proportional proportional JJ cord-004862-yv76yvy5 162 11 to to IN cord-004862-yv76yvy5 162 12 the the DT cord-004862-yv76yvy5 162 13 extent extent NN cord-004862-yv76yvy5 162 14 of of IN cord-004862-yv76yvy5 162 15 similarity similarity NN cord-004862-yv76yvy5 162 16 of of IN cord-004862-yv76yvy5 162 17 the the DT cord-004862-yv76yvy5 162 18 L L NNP cord-004862-yv76yvy5 162 19 10c 10c CD cord-004862-yv76yvy5 162 20 sequence sequence NN cord-004862-yv76yvy5 162 21 . . . cord-004862-yv76yvy5 163 1 The the DT cord-004862-yv76yvy5 163 2 percent percent NN cord-004862-yv76yvy5 163 3 identity identity NN cord-004862-yv76yvy5 163 4 ofthe ofthe DT cord-004862-yv76yvy5 163 5 encoded encode VBN cord-004862-yv76yvy5 163 6 amino amino NN cord-004862-yv76yvy5 163 7 acids acid NNS cord-004862-yv76yvy5 163 8 , , , cord-004862-yv76yvy5 163 9 compared compare VBN cord-004862-yv76yvy5 163 10 to to IN cord-004862-yv76yvy5 163 11 the the DT cord-004862-yv76yvy5 163 12 L1Oc L1Oc NNP cord-004862-yv76yvy5 163 13 sequence sequence NN cord-004862-yv76yvy5 163 14 , , , cord-004862-yv76yvy5 163 15 are be VBP cord-004862-yv76yvy5 163 16 given give VBN cord-004862-yv76yvy5 163 17 in in IN cord-004862-yv76yvy5 163 18 the the DT cord-004862-yv76yvy5 163 19 boxes box NNS cord-004862-yv76yvy5 163 20 . . . cord-004862-yv76yvy5 164 1 A a DT cord-004862-yv76yvy5 164 2 box box NN cord-004862-yv76yvy5 164 3 representing represent VBG cord-004862-yv76yvy5 164 4 a a DT cord-004862-yv76yvy5 164 5 portion portion NN cord-004862-yv76yvy5 164 6 of of IN cord-004862-yv76yvy5 164 7 the the DT cord-004862-yv76yvy5 164 8 type type NN cord-004862-yv76yvy5 164 9 II II NNP cord-004862-yv76yvy5 164 10 cytoskeletal cytoskeletal JJ cord-004862-yv76yvy5 164 11 keratin keratin NN cord-004862-yv76yvy5 164 12 sequence sequence NN cord-004862-yv76yvy5 164 13 is be VBZ cord-004862-yv76yvy5 164 14 aligned align VBN cord-004862-yv76yvy5 164 15 with with IN cord-004862-yv76yvy5 164 16 the the DT cord-004862-yv76yvy5 164 17 segment segment NN cord-004862-yv76yvy5 164 18 of of IN cord-004862-yv76yvy5 164 19 the the DT cord-004862-yv76yvy5 164 20 LIOc LIOc NNP cord-004862-yv76yvy5 164 21 sequence sequence NN cord-004862-yv76yvy5 164 22 that that WDT cord-004862-yv76yvy5 164 23 matches match VBZ cord-004862-yv76yvy5 164 24 it -PRON- PRP cord-004862-yv76yvy5 164 25 . . . cord-004862-yv76yvy5 165 1 The the DT cord-004862-yv76yvy5 165 2 percent percent NN cord-004862-yv76yvy5 165 3 of of IN cord-004862-yv76yvy5 165 4 amino amino JJ cord-004862-yv76yvy5 165 5 acids acid NNS cord-004862-yv76yvy5 165 6 identical identical JJ cord-004862-yv76yvy5 165 7 to to IN cord-004862-yv76yvy5 165 8 the the DT cord-004862-yv76yvy5 165 9 L1Oc L1Oc NNP cord-004862-yv76yvy5 165 10 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 165 11 translated translate VBN cord-004862-yv76yvy5 165 12 sequence sequence NN cord-004862-yv76yvy5 165 13 is be VBZ cord-004862-yv76yvy5 165 14 given give VBN cord-004862-yv76yvy5 165 15 in in IN cord-004862-yv76yvy5 165 16 the the DT cord-004862-yv76yvy5 165 17 boxes box NNS cord-004862-yv76yvy5 165 18 , , , cord-004862-yv76yvy5 165 19 and and CC cord-004862-yv76yvy5 165 20 the the DT cord-004862-yv76yvy5 165 21 amino amino NN cord-004862-yv76yvy5 165 22 acid acid NN cord-004862-yv76yvy5 165 23 positions position NNS cord-004862-yv76yvy5 165 24 in in IN cord-004862-yv76yvy5 165 25 the the DT cord-004862-yv76yvy5 165 26 keratin keratin NN cord-004862-yv76yvy5 165 27 sequence sequence NN cord-004862-yv76yvy5 165 28 are be VBP cord-004862-yv76yvy5 165 29 listed list VBN cord-004862-yv76yvy5 165 30 below below IN cord-004862-yv76yvy5 165 31 the the DT cord-004862-yv76yvy5 165 32 boxes box NNS cord-004862-yv76yvy5 165 33 . . . cord-004862-yv76yvy5 166 1 A a DT cord-004862-yv76yvy5 166 2 gap gap NN cord-004862-yv76yvy5 166 3 penalty penalty NN cord-004862-yv76yvy5 166 4 of of IN cord-004862-yv76yvy5 166 5 - - HYPH cord-004862-yv76yvy5 166 6 ! ! NN cord-004862-yv76yvy5 166 7 was be VBD cord-004862-yv76yvy5 166 8 assessed assess VBN cord-004862-yv76yvy5 166 9 in in IN cord-004862-yv76yvy5 166 10 calculating calculate VBG cord-004862-yv76yvy5 166 11 the the DT cord-004862-yv76yvy5 166 12 percent percent NN cord-004862-yv76yvy5 166 13 identities identity NNS cord-004862-yv76yvy5 166 14 . . . cord-004862-yv76yvy5 167 1 larity larity NNP cord-004862-yv76yvy5 167 2 corresponds correspond VBZ cord-004862-yv76yvy5 167 3 to to IN cord-004862-yv76yvy5 167 4 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 167 5 and and CC cord-004862-yv76yvy5 167 6 the the DT cord-004862-yv76yvy5 167 7 short short JJ cord-004862-yv76yvy5 167 8 region region NN cord-004862-yv76yvy5 167 9 of of IN cord-004862-yv76yvy5 167 10 similarity similarity NN cord-004862-yv76yvy5 167 11 corresponds correspond VBZ cord-004862-yv76yvy5 167 12 to to IN cord-004862-yv76yvy5 167 13 the the DT cord-004862-yv76yvy5 167 14 3 3 CD cord-004862-yv76yvy5 167 15 ' ' POS cord-004862-yv76yvy5 167 16 portion portion NN cord-004862-yv76yvy5 167 17 of of IN cord-004862-yv76yvy5 167 18 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 167 19 . . . cord-004862-yv76yvy5 168 1 The the DT cord-004862-yv76yvy5 168 2 two two CD cord-004862-yv76yvy5 168 3 ORFs orf NNS cord-004862-yv76yvy5 168 4 are be VBP cord-004862-yv76yvy5 168 5 overlapping overlap VBG cord-004862-yv76yvy5 168 6 in in IN cord-004862-yv76yvy5 168 7 L1Md L1Md NNP cord-004862-yv76yvy5 168 8 , , , cord-004862-yv76yvy5 168 9 and and CC cord-004862-yv76yvy5 168 10 it -PRON- PRP cord-004862-yv76yvy5 168 11 is be VBZ cord-004862-yv76yvy5 168 12 of of IN cord-004862-yv76yvy5 168 13 interest interest NN cord-004862-yv76yvy5 168 14 to to TO cord-004862-yv76yvy5 168 15 determine determine VB cord-004862-yv76yvy5 168 16 whether whether IN cord-004862-yv76yvy5 168 17 this this DT cord-004862-yv76yvy5 168 18 feature feature NN cord-004862-yv76yvy5 168 19 is be VBZ cord-004862-yv76yvy5 168 20 conserved conserve VBN cord-004862-yv76yvy5 168 21 in in IN cord-004862-yv76yvy5 168 22 LI LI NNP cord-004862-yv76yvy5 168 23 repeats repeat VBZ cord-004862-yv76yvy5 168 24 from from IN cord-004862-yv76yvy5 168 25 other other JJ cord-004862-yv76yvy5 168 26 species specie NNS cord-004862-yv76yvy5 168 27 . . . cord-004862-yv76yvy5 169 1 Also also RB cord-004862-yv76yvy5 169 2 , , , cord-004862-yv76yvy5 169 3 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 169 4 appears appear VBZ cord-004862-yv76yvy5 169 5 to to TO cord-004862-yv76yvy5 169 6 be be VB cord-004862-yv76yvy5 169 7 a a DT cord-004862-yv76yvy5 169 8 hybrid hybrid JJ cord-004862-yv76yvy5 169 9 sequence sequence NN cord-004862-yv76yvy5 169 10 because because IN cord-004862-yv76yvy5 169 11 it -PRON- PRP cord-004862-yv76yvy5 169 12 is be VBZ cord-004862-yv76yvy5 169 13 well well RB cord-004862-yv76yvy5 169 14 conserved conserve VBN cord-004862-yv76yvy5 169 15 between between IN cord-004862-yv76yvy5 169 16 species specie NNS cord-004862-yv76yvy5 169 17 in in IN cord-004862-yv76yvy5 169 18 the the DT cord-004862-yv76yvy5 169 19 3 3 CD cord-004862-yv76yvy5 169 20 ' ' NN cord-004862-yv76yvy5 169 21 half half NN cord-004862-yv76yvy5 170 1 but but CC cord-004862-yv76yvy5 170 2 it -PRON- PRP cord-004862-yv76yvy5 170 3 is be VBZ cord-004862-yv76yvy5 170 4 not not RB cord-004862-yv76yvy5 170 5 well well RB cord-004862-yv76yvy5 170 6 conserved conserve VBN cord-004862-yv76yvy5 170 7 in in IN cord-004862-yv76yvy5 170 8 the the DT cord-004862-yv76yvy5 170 9 5 5 CD cord-004862-yv76yvy5 170 10 ' ' CD cord-004862-yv76yvy5 170 11 half half NN cord-004862-yv76yvy5 170 12 . . . cord-004862-yv76yvy5 171 1 Therefore therefore RB cord-004862-yv76yvy5 171 2 , , , cord-004862-yv76yvy5 171 3 the the DT cord-004862-yv76yvy5 171 4 sequence sequence NN cord-004862-yv76yvy5 171 5 of of IN cord-004862-yv76yvy5 171 6 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 171 7 and and CC cord-004862-yv76yvy5 171 8 the the DT cord-004862-yv76yvy5 171 9 region region NN cord-004862-yv76yvy5 171 10 between between IN cord-004862-yv76yvy5 171 11 the the DT cord-004862-yv76yvy5 171 12 ORFs ORFs NNP cord-004862-yv76yvy5 171 13 were be VBD cord-004862-yv76yvy5 171 14 aligned align VBN cord-004862-yv76yvy5 171 15 for for IN cord-004862-yv76yvy5 171 16 the the DT cord-004862-yv76yvy5 171 17 L1 L1 NNP cord-004862-yv76yvy5 171 18 repeats repeat VBZ cord-004862-yv76yvy5 171 19 from from IN cord-004862-yv76yvy5 171 20 rabbit rabbit NN cord-004862-yv76yvy5 171 21 , , , cord-004862-yv76yvy5 171 22 mouse mouse NN cord-004862-yv76yvy5 171 23 , , , cord-004862-yv76yvy5 171 24 rat rat NN cord-004862-yv76yvy5 171 25 , , , cord-004862-yv76yvy5 171 26 and and CC cord-004862-yv76yvy5 171 27 humans human NNS cord-004862-yv76yvy5 171 28 . . . cord-004862-yv76yvy5 172 1 Figure figure NN cord-004862-yv76yvy5 172 2 8 8 CD cord-004862-yv76yvy5 172 3 shows show NNS cord-004862-yv76yvy5 172 4 both both CC cord-004862-yv76yvy5 172 5 the the DT cord-004862-yv76yvy5 172 6 aligned align VBN cord-004862-yv76yvy5 172 7 nucleotide nucleotide JJ cord-004862-yv76yvy5 172 8 sequences sequence NNS cord-004862-yv76yvy5 172 9 and and CC cord-004862-yv76yvy5 172 10 the the DT cord-004862-yv76yvy5 172 11 predicted predict VBN cord-004862-yv76yvy5 172 12 amino amino NN cord-004862-yv76yvy5 172 13 acid acid NN cord-004862-yv76yvy5 172 14 sequences sequence NNS cord-004862-yv76yvy5 172 15 . . . cord-004862-yv76yvy5 173 1 Sequences sequence NNS cord-004862-yv76yvy5 173 2 that that WDT cord-004862-yv76yvy5 173 3 match match VBP cord-004862-yv76yvy5 173 4 well well RB cord-004862-yv76yvy5 173 5 between between IN cord-004862-yv76yvy5 173 6 species specie NNS cord-004862-yv76yvy5 173 7 are be VBP cord-004862-yv76yvy5 173 8 in in IN cord-004862-yv76yvy5 173 9 reverse reverse JJ cord-004862-yv76yvy5 173 10 text text NN cord-004862-yv76yvy5 173 11 , , , cord-004862-yv76yvy5 173 12 whereas whereas IN cord-004862-yv76yvy5 173 13 sequences sequence NNS cord-004862-yv76yvy5 173 14 that that WDT cord-004862-yv76yvy5 173 15 do do VBP cord-004862-yv76yvy5 173 16 not not RB cord-004862-yv76yvy5 173 17 match match VB cord-004862-yv76yvy5 173 18 well well RB cord-004862-yv76yvy5 173 19 are be VBP cord-004862-yv76yvy5 173 20 in in IN cord-004862-yv76yvy5 173 21 plain plain JJ cord-004862-yv76yvy5 173 22 text text NN cord-004862-yv76yvy5 173 23 . . . cord-004862-yv76yvy5 174 1 Inspection inspection NN cord-004862-yv76yvy5 174 2 of of IN cord-004862-yv76yvy5 174 3 the the DT cord-004862-yv76yvy5 174 4 aligned align VBN cord-004862-yv76yvy5 174 5 L1 L1 NNP cord-004862-yv76yvy5 174 6 sequences sequence NNS cord-004862-yv76yvy5 174 7 allows allow VBZ cord-004862-yv76yvy5 174 8 a a DT cord-004862-yv76yvy5 174 9 tentative tentative JJ cord-004862-yv76yvy5 174 10 identification identification NN cord-004862-yv76yvy5 174 11 of of IN cord-004862-yv76yvy5 174 12 the the DT cord-004862-yv76yvy5 174 13 start start NN cord-004862-yv76yvy5 174 14 and and CC cord-004862-yv76yvy5 174 15 stop stop VB cord-004862-yv76yvy5 174 16 sites site NNS cord-004862-yv76yvy5 174 17 of of IN cord-004862-yv76yvy5 174 18 the the DT cord-004862-yv76yvy5 174 19 ORFs ORFs NNP cord-004862-yv76yvy5 174 20 . . . cord-004862-yv76yvy5 175 1 This this DT cord-004862-yv76yvy5 175 2 analysis analysis NN cord-004862-yv76yvy5 175 3 reveals reveal VBZ cord-004862-yv76yvy5 175 4 that that IN cord-004862-yv76yvy5 175 5 no no DT cord-004862-yv76yvy5 175 6 overlap overlap NN cord-004862-yv76yvy5 175 7 between between IN cord-004862-yv76yvy5 175 8 reading read VBG cord-004862-yv76yvy5 175 9 frames frame NNS cord-004862-yv76yvy5 175 10 is be VBZ cord-004862-yv76yvy5 175 11 seen see VBN cord-004862-yv76yvy5 175 12 in in IN cord-004862-yv76yvy5 175 13 rabbit rabbit NN cord-004862-yv76yvy5 175 14 and and CC cord-004862-yv76yvy5 175 15 human human JJ cord-004862-yv76yvy5 175 16 L1 L1 NNP cord-004862-yv76yvy5 175 17 repeats repeat VBZ cord-004862-yv76yvy5 175 18 . . . cord-004862-yv76yvy5 176 1 The the DT cord-004862-yv76yvy5 176 2 end end NN cord-004862-yv76yvy5 176 3 of of IN cord-004862-yv76yvy5 176 4 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 176 5 in in IN cord-004862-yv76yvy5 176 6 L1Md L1Md NNP cord-004862-yv76yvy5 176 7 is be VBZ cord-004862-yv76yvy5 176 8 the the DT cord-004862-yv76yvy5 176 9 TAA TAA NNP cord-004862-yv76yvy5 176 10 at at IN cord-004862-yv76yvy5 176 11 positions position NNS cord-004862-yv76yvy5 176 12 1163 1163 CD cord-004862-yv76yvy5 176 13 - - SYM cord-004862-yv76yvy5 176 14 1165 1165 CD cord-004862-yv76yvy5 177 1 ( ( -LRB- cord-004862-yv76yvy5 177 2 boldface boldface NNS cord-004862-yv76yvy5 177 3 in in IN cord-004862-yv76yvy5 177 4 Fig Fig NNP cord-004862-yv76yvy5 177 5 . . . cord-004862-yv76yvy5 177 6 8) 8) NNP cord-004862-yv76yvy5 177 7 . . . cord-004862-yv76yvy5 178 1 The the DT cord-004862-yv76yvy5 178 2 same same JJ cord-004862-yv76yvy5 178 3 sequence sequence NN cord-004862-yv76yvy5 178 4 is be VBZ cord-004862-yv76yvy5 178 5 found find VBN cord-004862-yv76yvy5 178 6 in in IN cord-004862-yv76yvy5 178 7 the the DT cord-004862-yv76yvy5 178 8 rat rat NN cord-004862-yv76yvy5 178 9 L1 L1 NNP cord-004862-yv76yvy5 178 10 sequence sequence NN cord-004862-yv76yvy5 178 11 ( ( -LRB- cord-004862-yv76yvy5 178 12 L L NNP cord-004862-yv76yvy5 178 13 1Rn 1rn CD cord-004862-yv76yvy5 178 14 ) ) -RRB- cord-004862-yv76yvy5 178 15 , , , cord-004862-yv76yvy5 178 16 and and CC cord-004862-yv76yvy5 178 17 in in IN cord-004862-yv76yvy5 178 18 - - HYPH cord-004862-yv76yvy5 178 19 phase phase NN cord-004862-yv76yvy5 178 20 terminators terminator NNS cord-004862-yv76yvy5 178 21 are be VBP cord-004862-yv76yvy5 178 22 found find VBN cord-004862-yv76yvy5 178 23 nearby nearby RB cord-004862-yv76yvy5 178 24 in in IN cord-004862-yv76yvy5 178 25 L10c L10c NNP cord-004862-yv76yvy5 178 26 and and CC cord-004862-yv76yvy5 178 27 L1Hs L1Hs NNP cord-004862-yv76yvy5 178 28 ( ( -LRB- cord-004862-yv76yvy5 178 29 boldface boldface NN cord-004862-yv76yvy5 178 30 TAAs TAAs NNP cord-004862-yv76yvy5 178 31 in in IN cord-004862-yv76yvy5 178 32 Fig Fig NNP cord-004862-yv76yvy5 178 33 . . . cord-004862-yv76yvy5 178 34 8 8 CD cord-004862-yv76yvy5 178 35 ) ) -RRB- cord-004862-yv76yvy5 178 36 . . . cord-004862-yv76yvy5 179 1 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 180 1 in in IN cord-004862-yv76yvy5 180 2 L1Md L1Md NNP cord-004862-yv76yvy5 180 3 begins begin VBZ cord-004862-yv76yvy5 180 4 in in IN cord-004862-yv76yvy5 180 5 a a DT cord-004862-yv76yvy5 180 6 different different JJ cord-004862-yv76yvy5 180 7 reading reading NN cord-004862-yv76yvy5 180 8 frame frame NN cord-004862-yv76yvy5 180 9 at at IN cord-004862-yv76yvy5 180 10 position position NN cord-004862-yv76yvy5 180 11 1149 1149 CD cord-004862-yv76yvy5 180 12 , , , cord-004862-yv76yvy5 180 13 and and CC cord-004862-yv76yvy5 180 14 thus thus RB cord-004862-yv76yvy5 180 15 it -PRON- PRP cord-004862-yv76yvy5 180 16 overlaps overlap VBZ cord-004862-yv76yvy5 180 17 with with IN cord-004862-yv76yvy5 180 18 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 180 19 for for IN cord-004862-yv76yvy5 180 20 14 14 CD cord-004862-yv76yvy5 180 21 nucleotides nucleotide NNS cord-004862-yv76yvy5 180 22 . . . cord-004862-yv76yvy5 181 1 By by IN cord-004862-yv76yvy5 181 2 aligning align VBG cord-004862-yv76yvy5 181 3 the the DT cord-004862-yv76yvy5 181 4 sequences sequence NNS cord-004862-yv76yvy5 181 5 of of IN cord-004862-yv76yvy5 181 6 the the DT cord-004862-yv76yvy5 181 7 different different JJ cord-004862-yv76yvy5 181 8 L1 L1 NNP cord-004862-yv76yvy5 181 9 s s NN cord-004862-yv76yvy5 181 10 in in IN cord-004862-yv76yvy5 181 11 the the DT cord-004862-yv76yvy5 181 12 well well RB cord-004862-yv76yvy5 181 13 - - HYPH cord-004862-yv76yvy5 181 14 conserved conserve VBN cord-004862-yv76yvy5 181 15 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 181 16 region region NN cord-004862-yv76yvy5 181 17 , , , cord-004862-yv76yvy5 181 18 it -PRON- PRP cord-004862-yv76yvy5 181 19 is be VBZ cord-004862-yv76yvy5 181 20 apparent apparent JJ cord-004862-yv76yvy5 181 21 that that IN cord-004862-yv76yvy5 181 22 an an DT cord-004862-yv76yvy5 181 23 ATG ATG NNP cord-004862-yv76yvy5 181 24 is be VBZ cord-004862-yv76yvy5 181 25 conserved conserve VBN cord-004862-yv76yvy5 181 26 in in IN cord-004862-yv76yvy5 181 27 the the DT cord-004862-yv76yvy5 181 28 rabbit rabbit NN cord-004862-yv76yvy5 181 29 and and CC cord-004862-yv76yvy5 181 30 human human JJ cord-004862-yv76yvy5 181 31 sequences sequence NNS cord-004862-yv76yvy5 181 32 at at IN cord-004862-yv76yvy5 181 33 positions position NNS cord-004862-yv76yvy5 181 34 1235 1235 CD cord-004862-yv76yvy5 181 35 - - SYM cord-004862-yv76yvy5 181 36 1237 1237 CD cord-004862-yv76yvy5 181 37 . . . cord-004862-yv76yvy5 182 1 An an DT cord-004862-yv76yvy5 182 2 in in IN cord-004862-yv76yvy5 182 3 - - HYPH cord-004862-yv76yvy5 182 4 frame frame NN cord-004862-yv76yvy5 182 5 ATG ATG NNP cord-004862-yv76yvy5 182 6 two two CD cord-004862-yv76yvy5 182 7 codons codon NNS cord-004862-yv76yvy5 182 8 upstream upstream RB cord-004862-yv76yvy5 182 9 was be VBD cord-004862-yv76yvy5 182 10 previously previously RB cord-004862-yv76yvy5 182 11 identified identify VBN cord-004862-yv76yvy5 182 12 as as IN cord-004862-yv76yvy5 182 13 the the DT cord-004862-yv76yvy5 182 14 start start NN cord-004862-yv76yvy5 182 15 of of IN cord-004862-yv76yvy5 182 16 ORFb ORFb NNS cord-004862-yv76yvy5 182 17 in in IN cord-004862-yv76yvy5 182 18 the the DT cord-004862-yv76yvy5 182 19 L1Rn l1rn CD cord-004862-yv76yvy5 182 20 sequence sequence NN cord-004862-yv76yvy5 183 1 ( ( -LRB- cord-004862-yv76yvy5 183 2 D'Ambrosio D'Ambrosio NNP cord-004862-yv76yvy5 183 3 et et NNP cord-004862-yv76yvy5 183 4 al al NNP cord-004862-yv76yvy5 183 5 . . NNP cord-004862-yv76yvy5 183 6 1986 1986 CD cord-004862-yv76yvy5 183 7 ) ) -RRB- cord-004862-yv76yvy5 183 8 and and CC cord-004862-yv76yvy5 183 9 an an DT cord-004862-yv76yvy5 183 10 ATG ATG NNP cord-004862-yv76yvy5 183 11 is be VBZ cord-004862-yv76yvy5 183 12 also also RB cord-004862-yv76yvy5 183 13 in in IN cord-004862-yv76yvy5 183 14 frame frame NN cord-004862-yv76yvy5 183 15 in in IN cord-004862-yv76yvy5 183 16 the the DT cord-004862-yv76yvy5 183 17 L1Md L1Md NNP cord-004862-yv76yvy5 183 18 sequence sequence NN cord-004862-yv76yvy5 183 19 seven seven CD cord-004862-yv76yvy5 183 20 codons codon NNS cord-004862-yv76yvy5 183 21 upstream upstream RB cord-004862-yv76yvy5 183 22 . . . cord-004862-yv76yvy5 184 1 One one PRP cord-004862-yv76yvy5 184 2 can can MD cord-004862-yv76yvy5 184 3 propose propose VB cord-004862-yv76yvy5 184 4 that that IN cord-004862-yv76yvy5 184 5 the the DT cord-004862-yv76yvy5 184 6 TAA TAA NNP cord-004862-yv76yvy5 184 7 close close NN cord-004862-yv76yvy5 184 8 to to TO cord-004862-yv76yvy5 184 9 position position NN cord-004862-yv76yvy5 184 10 1163 1163 CD cord-004862-yv76yvy5 184 11 is be VBZ cord-004862-yv76yvy5 184 12 the the DT cord-004862-yv76yvy5 184 13 end end NN cord-004862-yv76yvy5 184 14 of of IN cord-004862-yv76yvy5 184 15 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 184 16 and and CC cord-004862-yv76yvy5 184 17 the the DT cord-004862-yv76yvy5 184 18 ATG ATG NNP cord-004862-yv76yvy5 184 19 at at IN cord-004862-yv76yvy5 184 20 positions position NNS cord-004862-yv76yvy5 184 21 1235 1235 CD cord-004862-yv76yvy5 184 22 - - SYM cord-004862-yv76yvy5 184 23 1237 1237 CD cord-004862-yv76yvy5 184 24 is be VBZ cord-004862-yv76yvy5 184 25 the the DT cord-004862-yv76yvy5 184 26 start start NN cord-004862-yv76yvy5 184 27 of of IN cord-004862-yv76yvy5 184 28 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 184 29 in in IN cord-004862-yv76yvy5 184 30 rabbit rabbit NN cord-004862-yv76yvy5 184 31 and and CC cord-004862-yv76yvy5 184 32 human human JJ cord-004862-yv76yvy5 184 33 L1 L1 NNP cord-004862-yv76yvy5 184 34 repeats repeat VBZ cord-004862-yv76yvy5 184 35 . . . cord-004862-yv76yvy5 185 1 In in IN cord-004862-yv76yvy5 185 2 an an DT cord-004862-yv76yvy5 185 3 independent independent JJ cord-004862-yv76yvy5 185 4 analysis analysis NN cord-004862-yv76yvy5 185 5 of of IN cord-004862-yv76yvy5 185 6 several several JJ cord-004862-yv76yvy5 185 7 individual individual JJ cord-004862-yv76yvy5 185 8 L1Hs L1Hs NNP cord-004862-yv76yvy5 185 9 repeats repeat VBZ cord-004862-yv76yvy5 185 10 , , , cord-004862-yv76yvy5 185 11 these these DT cord-004862-yv76yvy5 185 12 same same JJ cord-004862-yv76yvy5 185 13 codons codon NNS cord-004862-yv76yvy5 185 14 were be VBD cord-004862-yv76yvy5 185 15 assigned assign VBN cord-004862-yv76yvy5 185 16 as as IN cord-004862-yv76yvy5 185 17 the the DT cord-004862-yv76yvy5 185 18 end end NN cord-004862-yv76yvy5 185 19 of of IN cord-004862-yv76yvy5 185 20 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 185 21 and and CC cord-004862-yv76yvy5 185 22 the the DT cord-004862-yv76yvy5 185 23 start start NN cord-004862-yv76yvy5 185 24 of of IN cord-004862-yv76yvy5 185 25 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 185 26 in in IN cord-004862-yv76yvy5 185 27 the the DT cord-004862-yv76yvy5 185 28 consensus consensus NN cord-004862-yv76yvy5 185 29 L L NNP cord-004862-yv76yvy5 185 30 1Hs 1Hs NNP cord-004862-yv76yvy5 185 31 sequence sequence NN cord-004862-yv76yvy5 186 1 ( ( -LRB- cord-004862-yv76yvy5 186 2 Scott Scott NNP cord-004862-yv76yvy5 186 3 et et NNP cord-004862-yv76yvy5 186 4 al al NNP cord-004862-yv76yvy5 186 5 . . NNP cord-004862-yv76yvy5 186 6 1987 1987 CD cord-004862-yv76yvy5 186 7 ) ) -RRB- cord-004862-yv76yvy5 186 8 . . . cord-004862-yv76yvy5 187 1 As as IN cord-004862-yv76yvy5 187 2 shown show VBN cord-004862-yv76yvy5 187 3 in in IN cord-004862-yv76yvy5 187 4 Fig Fig NNP cord-004862-yv76yvy5 187 5 . . . cord-004862-yv76yvy5 188 1 8 8 CD cord-004862-yv76yvy5 188 2 , , , cord-004862-yv76yvy5 188 3 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 188 4 is be VBZ cord-004862-yv76yvy5 188 5 in in IN cord-004862-yv76yvy5 188 6 the the DT cord-004862-yv76yvy5 188 7 same same JJ cord-004862-yv76yvy5 188 8 reading reading NN cord-004862-yv76yvy5 188 9 frame frame NN cord-004862-yv76yvy5 188 10 as as IN cord-004862-yv76yvy5 188 11 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 188 12 in in IN cord-004862-yv76yvy5 188 13 the the DT cord-004862-yv76yvy5 188 14 L L NNP cord-004862-yv76yvy5 188 15 10c 10c NNPS cord-004862-yv76yvy5 188 16 and and CC cord-004862-yv76yvy5 188 17 L L NNP cord-004862-yv76yvy5 188 18 1Hs 1hs NN cord-004862-yv76yvy5 188 19 sequences sequence NNS cord-004862-yv76yvy5 188 20 . . . cord-004862-yv76yvy5 189 1 Thus thus RB cord-004862-yv76yvy5 189 2 , , , cord-004862-yv76yvy5 189 3 the the DT cord-004862-yv76yvy5 189 4 overlap overlap NN cord-004862-yv76yvy5 189 5 in in IN cord-004862-yv76yvy5 189 6 reading read VBG cord-004862-yv76yvy5 189 7 frames frame NNS cord-004862-yv76yvy5 189 8 seen see VBN cord-004862-yv76yvy5 189 9 for for IN cord-004862-yv76yvy5 189 10 L1Md L1Md NNP cord-004862-yv76yvy5 189 11 is be VBZ cord-004862-yv76yvy5 189 12 not not RB cord-004862-yv76yvy5 189 13 observed observe VBN cord-004862-yv76yvy5 189 14 in in IN cord-004862-yv76yvy5 189 15 L1Oc L1Oc NNP cord-004862-yv76yvy5 189 16 and and CC cord-004862-yv76yvy5 189 17 L1Hs L1Hs NNP cord-004862-yv76yvy5 189 18 . . . cord-004862-yv76yvy5 190 1 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 190 2 in in IN cord-004862-yv76yvy5 190 3 L1Rn L1Rn NNP cord-004862-yv76yvy5 190 4 is be VBZ cord-004862-yv76yvy5 190 5 in in IN cord-004862-yv76yvy5 190 6 a a DT cord-004862-yv76yvy5 190 7 different different JJ cord-004862-yv76yvy5 190 8 reading reading NN cord-004862-yv76yvy5 190 9 frame frame NN cord-004862-yv76yvy5 190 10 than than IN cord-004862-yv76yvy5 190 11 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 190 12 , , , cord-004862-yv76yvy5 190 13 but but CC cord-004862-yv76yvy5 190 14 the the DT cord-004862-yv76yvy5 190 15 L1Rn l1rn CD cord-004862-yv76yvy5 190 16 sequence sequence NN cord-004862-yv76yvy5 190 17 does do VBZ cord-004862-yv76yvy5 190 18 have have VB cord-004862-yv76yvy5 190 19 an an DT cord-004862-yv76yvy5 190 20 ATG ATG NNP cord-004862-yv76yvy5 190 21 proposed propose VBN cord-004862-yv76yvy5 190 22 as as IN cord-004862-yv76yvy5 190 23 the the DT cord-004862-yv76yvy5 190 24 start start NN cord-004862-yv76yvy5 190 25 of of IN cord-004862-yv76yvy5 190 26 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 190 27 . . . cord-004862-yv76yvy5 191 1 Thus thus RB cord-004862-yv76yvy5 191 2 , , , cord-004862-yv76yvy5 191 3 LIRn lirn NN cord-004862-yv76yvy5 191 4 has have VBZ cord-004862-yv76yvy5 191 5 overlapping overlap VBG cord-004862-yv76yvy5 191 6 reading reading NN cord-004862-yv76yvy5 191 7 frames frame NNS cord-004862-yv76yvy5 191 8 , , , cord-004862-yv76yvy5 191 9 but but CC cord-004862-yv76yvy5 191 10 the the DT cord-004862-yv76yvy5 191 11 sequence sequence NN cord-004862-yv76yvy5 191 12 in in IN cord-004862-yv76yvy5 191 13 the the DT cord-004862-yv76yvy5 191 14 overlap overlap NN cord-004862-yv76yvy5 191 15 may may MD cord-004862-yv76yvy5 191 16 not not RB cord-004862-yv76yvy5 191 17 be be VB cord-004862-yv76yvy5 191 18 used use VBN cord-004862-yv76yvy5 191 19 to to TO cord-004862-yv76yvy5 191 20 encode encode VB cord-004862-yv76yvy5 191 21 a a DT cord-004862-yv76yvy5 191 22 protein protein NN cord-004862-yv76yvy5 191 23 . . . cord-004862-yv76yvy5 192 1 The the DT cord-004862-yv76yvy5 192 2 region region NN cord-004862-yv76yvy5 192 3 between between IN cord-004862-yv76yvy5 192 4 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 192 5 and and CC cord-004862-yv76yvy5 192 6 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 192 7 is be VBZ cord-004862-yv76yvy5 192 8 not not RB cord-004862-yv76yvy5 192 9 conserved conserve VBN cord-004862-yv76yvy5 192 10 between between IN cord-004862-yv76yvy5 192 11 mammalian mammalian JJ cord-004862-yv76yvy5 192 12 species specie NNS cord-004862-yv76yvy5 192 13 . . . cord-004862-yv76yvy5 193 1 The the DT cord-004862-yv76yvy5 193 2 sequence sequence NN cord-004862-yv76yvy5 193 3 between between IN cord-004862-yv76yvy5 193 4 the the DT cord-004862-yv76yvy5 193 5 TAA TAA NNP cord-004862-yv76yvy5 193 6 that that WDT cord-004862-yv76yvy5 193 7 ends end VBZ cord-004862-yv76yvy5 193 8 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 194 1 and and CC cord-004862-yv76yvy5 194 2 the the DT cord-004862-yv76yvy5 194 3 ATG ATG NNP cord-004862-yv76yvy5 194 4 proposed propose VBD cord-004862-yv76yvy5 194 5 to to TO cord-004862-yv76yvy5 194 6 be be VB cord-004862-yv76yvy5 194 7 the the DT cord-004862-yv76yvy5 194 8 start start NN cord-004862-yv76yvy5 194 9 of of IN cord-004862-yv76yvy5 194 10 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 195 1 is be VBZ cord-004862-yv76yvy5 195 2 in in IN cord-004862-yv76yvy5 195 3 a a DT cord-004862-yv76yvy5 195 4 region region NN cord-004862-yv76yvy5 195 5 that that WDT cord-004862-yv76yvy5 195 6 is be VBZ cord-004862-yv76yvy5 195 7 quite quite RB cord-004862-yv76yvy5 195 8 dissimilar dissimilar JJ cord-004862-yv76yvy5 195 9 between between IN cord-004862-yv76yvy5 195 10 rabbit rabbit NN cord-004862-yv76yvy5 195 11 and and CC cord-004862-yv76yvy5 195 12 mouse mouse NN cord-004862-yv76yvy5 195 13 and and CC cord-004862-yv76yvy5 195 14 between between IN cord-004862-yv76yvy5 195 15 rabbit rabbit NN cord-004862-yv76yvy5 195 16 and and CC cord-004862-yv76yvy5 195 17 human human JJ cord-004862-yv76yvy5 195 18 ( ( -LRB- cord-004862-yv76yvy5 195 19 plain plain JJ cord-004862-yv76yvy5 195 20 text text NN cord-004862-yv76yvy5 195 21 region region NN cord-004862-yv76yvy5 195 22 between between IN cord-004862-yv76yvy5 195 23 positions position NNS cord-004862-yv76yvy5 195 24 1121 1121 CD cord-004862-yv76yvy5 195 25 and and CC cord-004862-yv76yvy5 195 26 1240 1240 CD cord-004862-yv76yvy5 195 27 in in IN cord-004862-yv76yvy5 195 28 Fig Fig NNP cord-004862-yv76yvy5 195 29 . . NNP cord-004862-yv76yvy5 195 30 8 8 CD cord-004862-yv76yvy5 195 31 ) ) -RRB- cord-004862-yv76yvy5 195 32 . . . cord-004862-yv76yvy5 196 1 This this DT cord-004862-yv76yvy5 196 2 is be VBZ cord-004862-yv76yvy5 196 3 the the DT cord-004862-yv76yvy5 196 4 region region NN cord-004862-yv76yvy5 196 5 of of IN cord-004862-yv76yvy5 196 6 no no DT cord-004862-yv76yvy5 196 7 similarity similarity NN cord-004862-yv76yvy5 196 8 previously previously RB cord-004862-yv76yvy5 196 9 seen see VBN cord-004862-yv76yvy5 196 10 in in IN cord-004862-yv76yvy5 196 11 dotplots dotplot NNS cord-004862-yv76yvy5 196 12 ( ( -LRB- cord-004862-yv76yvy5 196 13 Fig Fig NNP cord-004862-yv76yvy5 196 14 . . . cord-004862-yv76yvy5 196 15 6 6 CD cord-004862-yv76yvy5 196 16 ) ) -RRB- cord-004862-yv76yvy5 196 17 . . . cord-004862-yv76yvy5 197 1 The the DT cord-004862-yv76yvy5 197 2 sequence sequence NN cord-004862-yv76yvy5 197 3 between between IN cord-004862-yv76yvy5 197 4 the the DT cord-004862-yv76yvy5 197 5 L1 L1 NNP cord-004862-yv76yvy5 197 6 ORFs ORFs NNP cord-004862-yv76yvy5 197 7 is be VBZ cord-004862-yv76yvy5 197 8 also also RB cord-004862-yv76yvy5 197 9 not not RB cord-004862-yv76yvy5 197 10 conserved conserve VBN cord-004862-yv76yvy5 197 11 in in IN cord-004862-yv76yvy5 197 12 comparisons comparison NNS cord-004862-yv76yvy5 197 13 between between IN cord-004862-yv76yvy5 197 14 the the DT cord-004862-yv76yvy5 197 15 human human JJ cord-004862-yv76yvy5 197 16 and and CC cord-004862-yv76yvy5 197 17 rodent rodent NN cord-004862-yv76yvy5 197 18 sequences sequence NNS cord-004862-yv76yvy5 197 19 ( ( -LRB- cord-004862-yv76yvy5 197 20 Scott Scott NNP cord-004862-yv76yvy5 197 21 et et NNP cord-004862-yv76yvy5 197 22 al al NNP cord-004862-yv76yvy5 197 23 . . NNP cord-004862-yv76yvy5 197 24 1987 1987 CD cord-004862-yv76yvy5 197 25 ) ) -RRB- cord-004862-yv76yvy5 197 26 . . . cord-004862-yv76yvy5 198 1 Because because IN cord-004862-yv76yvy5 198 2 this this DT cord-004862-yv76yvy5 198 3 region region NN cord-004862-yv76yvy5 198 4 is be VBZ cord-004862-yv76yvy5 198 5 not not RB cord-004862-yv76yvy5 198 6 conserved conserve VBN cord-004862-yv76yvy5 198 7 , , , cord-004862-yv76yvy5 198 8 whereas whereas IN cord-004862-yv76yvy5 198 9 the the DT cord-004862-yv76yvy5 198 10 sequences sequence NNS cord-004862-yv76yvy5 198 11 before before IN cord-004862-yv76yvy5 198 12 and and CC cord-004862-yv76yvy5 198 13 after after IN cord-004862-yv76yvy5 198 14 it -PRON- PRP cord-004862-yv76yvy5 198 15 are be VBP cord-004862-yv76yvy5 198 16 conserved conserve VBN cord-004862-yv76yvy5 198 17 , , , cord-004862-yv76yvy5 198 18 probably probably RB cord-004862-yv76yvy5 198 19 for for IN cord-004862-yv76yvy5 198 20 their -PRON- PRP$ cord-004862-yv76yvy5 198 21 capacity capacity NN cord-004862-yv76yvy5 198 22 to to TO cord-004862-yv76yvy5 198 23 encode encode VB cord-004862-yv76yvy5 198 24 a a DT cord-004862-yv76yvy5 198 25 protein protein NN cord-004862-yv76yvy5 198 26 , , , cord-004862-yv76yvy5 198 27 it -PRON- PRP cord-004862-yv76yvy5 198 28 is be VBZ cord-004862-yv76yvy5 198 29 unlikely unlikely JJ cord-004862-yv76yvy5 198 30 that that IN cord-004862-yv76yvy5 198 31 the the DT cord-004862-yv76yvy5 198 32 inter inter JJ cord-004862-yv76yvy5 198 33 - - JJ cord-004862-yv76yvy5 198 34 ORF ORF NNP cord-004862-yv76yvy5 198 35 region region NN cord-004862-yv76yvy5 198 36 encodes encode VBZ cord-004862-yv76yvy5 198 37 a a DT cord-004862-yv76yvy5 198 38 protein protein NN cord-004862-yv76yvy5 198 39 . . . cord-004862-yv76yvy5 199 1 This this DT cord-004862-yv76yvy5 199 2 lack lack NN cord-004862-yv76yvy5 199 3 of of IN cord-004862-yv76yvy5 199 4 conservation conservation NN cord-004862-yv76yvy5 199 5 supports support VBZ cord-004862-yv76yvy5 199 6 the the DT cord-004862-yv76yvy5 199 7 proposed propose VBN cord-004862-yv76yvy5 199 8 assignments assignment NNS cord-004862-yv76yvy5 199 9 for for IN cord-004862-yv76yvy5 199 10 the the DT cord-004862-yv76yvy5 199 11 start start NN cord-004862-yv76yvy5 199 12 of of IN cord-004862-yv76yvy5 199 13 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 199 14 in in IN cord-004862-yv76yvy5 199 15 L1Oc L1Oc NNP cord-004862-yv76yvy5 199 16 and and CC cord-004862-yv76yvy5 199 17 L1Hs L1Hs NNP cord-004862-yv76yvy5 199 18 . . . cord-004862-yv76yvy5 200 1 The the DT cord-004862-yv76yvy5 200 2 mouse mouse NN cord-004862-yv76yvy5 200 3 L1 l1 NN cord-004862-yv76yvy5 200 4 sequence sequence NN cord-004862-yv76yvy5 200 5 is be VBZ cord-004862-yv76yvy5 200 6 ATA ATA NNP cord-004862-yv76yvy5 200 7 at at IN cord-004862-yv76yvy5 200 8 positions position NNS cord-004862-yv76yvy5 200 9 1235 1235 CD cord-004862-yv76yvy5 200 10 - - SYM cord-004862-yv76yvy5 200 11 1237 1237 CD cord-004862-yv76yvy5 200 12 ; ; : cord-004862-yv76yvy5 200 13 this this DT cord-004862-yv76yvy5 200 14 same same JJ cord-004862-yv76yvy5 200 15 sequence sequence NN cord-004862-yv76yvy5 200 16 is be VBZ cord-004862-yv76yvy5 200 17 found find VBN cord-004862-yv76yvy5 200 18 in in IN cord-004862-yv76yvy5 200 19 three three CD cord-004862-yv76yvy5 200 20 sequenced sequence VBN cord-004862-yv76yvy5 200 21 members member NNS cord-004862-yv76yvy5 200 22 of of IN cord-004862-yv76yvy5 200 23 the the DT cord-004862-yv76yvy5 200 24 L1Md L1Md NNP cord-004862-yv76yvy5 200 25 family family NN cord-004862-yv76yvy5 200 26 ( ( -LRB- cord-004862-yv76yvy5 200 27 Shehee Shehee NNP cord-004862-yv76yvy5 200 28 et et NNP cord-004862-yv76yvy5 200 29 al al NNP cord-004862-yv76yvy5 200 30 . . NNP cord-004862-yv76yvy5 200 31 1987 1987 CD cord-004862-yv76yvy5 200 32 ) ) -RRB- cord-004862-yv76yvy5 200 33 . . . cord-004862-yv76yvy5 201 1 Therefore therefore RB cord-004862-yv76yvy5 201 2 , , , cord-004862-yv76yvy5 201 3 the the DT cord-004862-yv76yvy5 201 4 overlap overlap NN cord-004862-yv76yvy5 201 5 between between IN cord-004862-yv76yvy5 201 6 reading read VBG cord-004862-yv76yvy5 201 7 frames frame NNS cord-004862-yv76yvy5 201 8 1 1 CD cord-004862-yv76yvy5 201 9 and and CC cord-004862-yv76yvy5 201 10 2 2 CD cord-004862-yv76yvy5 201 11 are be VBP cord-004862-yv76yvy5 201 12 conserved conserve VBN cord-004862-yv76yvy5 201 13 in in IN cord-004862-yv76yvy5 201 14 mouse mouse NN cord-004862-yv76yvy5 201 15 Lls Lls NNP cord-004862-yv76yvy5 201 16 , , , cord-004862-yv76yvy5 201 17 but but CC cord-004862-yv76yvy5 201 18 the the DT cord-004862-yv76yvy5 201 19 overlaps overlap NNS cord-004862-yv76yvy5 201 20 are be VBP cord-004862-yv76yvy5 201 21 not not RB cord-004862-yv76yvy5 201 22 seen see VBN cord-004862-yv76yvy5 201 23 in in IN cord-004862-yv76yvy5 201 24 the the DT cord-004862-yv76yvy5 201 25 rabbit rabbit NN cord-004862-yv76yvy5 201 26 and and CC cord-004862-yv76yvy5 201 27 human human JJ cord-004862-yv76yvy5 201 28 L1 L1 NNP cord-004862-yv76yvy5 201 29 sequences sequence NNS cord-004862-yv76yvy5 201 30 . . . cord-004862-yv76yvy5 202 1 The the DT cord-004862-yv76yvy5 202 2 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 202 3 sequence sequence NN cord-004862-yv76yvy5 202 4 is be VBZ cord-004862-yv76yvy5 202 5 a a DT cord-004862-yv76yvy5 202 6 composite composite NN cord-004862-yv76yvy5 202 7 of of IN cord-004862-yv76yvy5 202 8 conserved conserved JJ cord-004862-yv76yvy5 202 9 and and CC cord-004862-yv76yvy5 202 10 nonconserved nonconserved JJ cord-004862-yv76yvy5 202 11 regions region NNS cord-004862-yv76yvy5 202 12 . . . cord-004862-yv76yvy5 203 1 As as IN cord-004862-yv76yvy5 203 2 shown show VBN cord-004862-yv76yvy5 203 3 diagrammatically diagrammatically RB cord-004862-yv76yvy5 203 4 in in IN cord-004862-yv76yvy5 203 5 Fig Fig NNP cord-004862-yv76yvy5 203 6 . . NNP cord-004862-yv76yvy5 203 7 9 9 CD cord-004862-yv76yvy5 203 8 , , , cord-004862-yv76yvy5 203 9 codons codon NNS cord-004862-yv76yvy5 203 10 79 79 CD cord-004862-yv76yvy5 203 11 - - SYM cord-004862-yv76yvy5 203 12 294 294 CD cord-004862-yv76yvy5 203 13 are be VBP cord-004862-yv76yvy5 203 14 highly highly RB cord-004862-yv76yvy5 203 15 related relate VBN cord-004862-yv76yvy5 203 16 between between IN cord-004862-yv76yvy5 203 17 species specie NNS cord-004862-yv76yvy5 203 18 in in IN cord-004862-yv76yvy5 203 19 different different JJ cord-004862-yv76yvy5 203 20 mammalian mammalian JJ cord-004862-yv76yvy5 203 21 orders order NNS cord-004862-yv76yvy5 203 22 , , , cord-004862-yv76yvy5 203 23 and and CC cord-004862-yv76yvy5 203 24 a a DT cord-004862-yv76yvy5 203 25 long long JJ cord-004862-yv76yvy5 203 26 segment segment NN cord-004862-yv76yvy5 203 27 from from IN cord-004862-yv76yvy5 203 28 codons codon NNS cord-004862-yv76yvy5 203 29 171 171 CD cord-004862-yv76yvy5 203 30 through through IN cord-004862-yv76yvy5 203 31 294 294 CD cord-004862-yv76yvy5 203 32 shows show NNS cord-004862-yv76yvy5 203 33 a a DT cord-004862-yv76yvy5 203 34 52 52 CD cord-004862-yv76yvy5 203 35 - - SYM cord-004862-yv76yvy5 203 36 56 56 CD cord-004862-yv76yvy5 203 37 % % NN cord-004862-yv76yvy5 203 38 amino amino NN cord-004862-yv76yvy5 203 39 acid acid NN cord-004862-yv76yvy5 203 40 identity identity NN cord-004862-yv76yvy5 203 41 in in IN cord-004862-yv76yvy5 203 42 these these DT cord-004862-yv76yvy5 203 43 comparisons comparison NNS cord-004862-yv76yvy5 203 44 . . . cord-004862-yv76yvy5 204 1 A a DT cord-004862-yv76yvy5 204 2 short short JJ cord-004862-yv76yvy5 204 3 region region NN cord-004862-yv76yvy5 204 4 from from IN cord-004862-yv76yvy5 204 5 codons codon NNS cord-004862-yv76yvy5 204 6 97 97 CD cord-004862-yv76yvy5 204 7 to to TO cord-004862-yv76yvy5 204 8 122 122 CD cord-004862-yv76yvy5 204 9 is be VBZ cord-004862-yv76yvy5 204 10 not not RB cord-004862-yv76yvy5 204 11 conserved conserve VBN cord-004862-yv76yvy5 204 12 , , , cord-004862-yv76yvy5 204 13 nor nor CC cord-004862-yv76yvy5 204 14 are be VBP cord-004862-yv76yvy5 204 15 the the DT cord-004862-yv76yvy5 204 16 last last JJ cord-004862-yv76yvy5 204 17 14 14 CD cord-004862-yv76yvy5 204 18 codons codon NNS cord-004862-yv76yvy5 204 19 in in IN cord-004862-yv76yvy5 204 20 the the DT cord-004862-yv76yvy5 204 21 sequence sequence NN cord-004862-yv76yvy5 204 22 , , , cord-004862-yv76yvy5 204 23 but but CC cord-004862-yv76yvy5 204 24 in in IN cord-004862-yv76yvy5 204 25 general general JJ cord-004862-yv76yvy5 204 26 the the DT cord-004862-yv76yvy5 204 27 C C NNP cord-004862-yv76yvy5 204 28 - - HYPH cord-004862-yv76yvy5 204 29 terminal terminal NN cord-004862-yv76yvy5 204 30 two two CD cord-004862-yv76yvy5 204 31 - - HYPH cord-004862-yv76yvy5 204 32 thirds third NNS cord-004862-yv76yvy5 204 33 of of IN cord-004862-yv76yvy5 204 34 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 204 35 is be VBZ cord-004862-yv76yvy5 204 36 conserved conserve VBN cord-004862-yv76yvy5 204 37 between between IN cord-004862-yv76yvy5 204 38 orders order NNS cord-004862-yv76yvy5 204 39 . . . cord-004862-yv76yvy5 205 1 A a DT cord-004862-yv76yvy5 205 2 search search NN cord-004862-yv76yvy5 205 3 through through IN cord-004862-yv76yvy5 205 4 the the DT cord-004862-yv76yvy5 205 5 databanks databank NNS cord-004862-yv76yvy5 205 6 at at IN cord-004862-yv76yvy5 205 7 the the DT cord-004862-yv76yvy5 205 8 Protein Protein NNP cord-004862-yv76yvy5 205 9 Identification Identification NNP cord-004862-yv76yvy5 205 10 Resource Resource NNP cord-004862-yv76yvy5 205 11 ( ( -LRB- cord-004862-yv76yvy5 205 12 National National NNP cord-004862-yv76yvy5 205 13 Biomedical Biomedical NNP cord-004862-yv76yvy5 205 14 Research Research NNP cord-004862-yv76yvy5 205 15 Foundation Foundation NNP cord-004862-yv76yvy5 205 16 ) ) -RRB- cord-004862-yv76yvy5 205 17 did do VBD cord-004862-yv76yvy5 205 18 not not RB cord-004862-yv76yvy5 205 19 identify identify VB cord-004862-yv76yvy5 205 20 any any DT cord-004862-yv76yvy5 205 21 known know VBN cord-004862-yv76yvy5 205 22 proteins protein NNS cord-004862-yv76yvy5 205 23 ( ( -LRB- cord-004862-yv76yvy5 205 24 besides besides IN cord-004862-yv76yvy5 205 25 the the DT cord-004862-yv76yvy5 205 26 L1 L1 NNP cord-004862-yv76yvy5 205 27 proteins protein NNS cord-004862-yv76yvy5 205 28 ) ) -RRB- cord-004862-yv76yvy5 206 1 that that WDT cord-004862-yv76yvy5 206 2 are be VBP cord-004862-yv76yvy5 206 3 related relate VBN cord-004862-yv76yvy5 206 4 to to IN cord-004862-yv76yvy5 206 5 the the DT cord-004862-yv76yvy5 206 6 C C NNP cord-004862-yv76yvy5 206 7 - - HYPH cord-004862-yv76yvy5 206 8 terminal terminal NN cord-004862-yv76yvy5 206 9 half half NN cord-004862-yv76yvy5 206 10 of of IN cord-004862-yv76yvy5 206 11 the the DT cord-004862-yv76yvy5 206 12 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 206 13 sequence sequence NN cord-004862-yv76yvy5 206 14 . . . cord-004862-yv76yvy5 207 1 ( ( -LRB- cord-004862-yv76yvy5 207 2 Lipman Lipman NNP cord-004862-yv76yvy5 207 3 and and CC cord-004862-yv76yvy5 207 4 Pearson Pearson NNP cord-004862-yv76yvy5 207 5 1985 1985 CD cord-004862-yv76yvy5 207 6 ) ) -RRB- cord-004862-yv76yvy5 207 7 is be VBZ cord-004862-yv76yvy5 207 8 shown show VBN cord-004862-yv76yvy5 207 9 starting start VBG cord-004862-yv76yvy5 207 10 at at IN cord-004862-yv76yvy5 207 11 amino amino NN cord-004862-yv76yvy5 207 12 acid acid NN cord-004862-yv76yvy5 207 13 position position NN cord-004862-yv76yvy5 207 14 1 1 CD cord-004862-yv76yvy5 207 15 of of IN cord-004862-yv76yvy5 207 16 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 207 17 from from IN cord-004862-yv76yvy5 207 18 L1Oc5 L1Oc5 NNP cord-004862-yv76yvy5 207 19 ( ( -LRB- cord-004862-yv76yvy5 207 20 Fig Fig NNP cord-004862-yv76yvy5 207 21 . . . cord-004862-yv76yvy5 207 22 8) 8) NNP cord-004862-yv76yvy5 208 1 and and CC cord-004862-yv76yvy5 208 2 position position VB cord-004862-yv76yvy5 208 3 303 303 CD cord-004862-yv76yvy5 208 4 of of IN cord-004862-yv76yvy5 208 5 the the DT cord-004862-yv76yvy5 208 6 sequence sequence NN cord-004862-yv76yvy5 208 7 of of IN cord-004862-yv76yvy5 208 8 type type NN cord-004862-yv76yvy5 208 9 II II NNP cord-004862-yv76yvy5 208 10 cytoskeletal cytoskeletal JJ cord-004862-yv76yvy5 208 11 keratin keratin NN cord-004862-yv76yvy5 208 12 of of IN cord-004862-yv76yvy5 208 13 humans human NNS cord-004862-yv76yvy5 208 14 ( ( -LRB- cord-004862-yv76yvy5 208 15 Johnson Johnson NNP cord-004862-yv76yvy5 208 16 el el NNP cord-004862-yv76yvy5 208 17 al al NNP cord-004862-yv76yvy5 208 18 . . . cord-004862-yv76yvy5 208 19 1985 1985 CD cord-004862-yv76yvy5 208 20 ) ) -RRB- cord-004862-yv76yvy5 208 21 . . . cord-004862-yv76yvy5 209 1 The the DT cord-004862-yv76yvy5 209 2 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 209 3 sequence sequence NN cord-004862-yv76yvy5 209 4 of of IN cord-004862-yv76yvy5 209 5 rabbit rabbit NN cord-004862-yv76yvy5 209 6 L1 L1 NNP cord-004862-yv76yvy5 209 7 is be VBZ cord-004862-yv76yvy5 209 8 labeled label VBN cord-004862-yv76yvy5 209 9 LI LI NNP cord-004862-yv76yvy5 209 10 , , , cord-004862-yv76yvy5 209 11 and and CC cord-004862-yv76yvy5 209 12 the the DT cord-004862-yv76yvy5 209 13 type type NN cord-004862-yv76yvy5 209 14 II II NNP cord-004862-yv76yvy5 209 15 keratin keratin NN cord-004862-yv76yvy5 209 16 sequence sequence NN cord-004862-yv76yvy5 209 17 is be VBZ cord-004862-yv76yvy5 209 18 labeled label VBN cord-004862-yv76yvy5 209 19 KII KII NNP cord-004862-yv76yvy5 209 20 . . . cord-004862-yv76yvy5 210 1 Identical identical JJ cord-004862-yv76yvy5 210 2 amino amino JJ cord-004862-yv76yvy5 210 3 acids acid NNS cord-004862-yv76yvy5 210 4 are be VBP cord-004862-yv76yvy5 210 5 indicated indicate VBN cord-004862-yv76yvy5 210 6 by by IN cord-004862-yv76yvy5 210 7 colons colon NNS cord-004862-yv76yvy5 210 8 , , , cord-004862-yv76yvy5 210 9 and and CC cord-004862-yv76yvy5 210 10 similar similar JJ cord-004862-yv76yvy5 210 11 amino amino JJ cord-004862-yv76yvy5 210 12 acids acid NNS cord-004862-yv76yvy5 210 13 are be VBP cord-004862-yv76yvy5 210 14 indicated indicate VBN cord-004862-yv76yvy5 210 15 by by IN cord-004862-yv76yvy5 210 16 periods period NNS cord-004862-yv76yvy5 210 17 . . . cord-004862-yv76yvy5 211 1 The the DT cord-004862-yv76yvy5 211 2 following follow VBG cord-004862-yv76yvy5 211 3 groups group NNS cord-004862-yv76yvy5 211 4 of of IN cord-004862-yv76yvy5 211 5 amino amino JJ cord-004862-yv76yvy5 211 6 acids acid NNS cord-004862-yv76yvy5 211 7 are be VBP cord-004862-yv76yvy5 211 8 considered consider VBN cord-004862-yv76yvy5 211 9 similar similar JJ cord-004862-yv76yvy5 211 10 : : : cord-004862-yv76yvy5 211 11 P p NN cord-004862-yv76yvy5 211 12 , , , cord-004862-yv76yvy5 211 13 A A NNP cord-004862-yv76yvy5 211 14 , , , cord-004862-yv76yvy5 211 15 G G NNP cord-004862-yv76yvy5 211 16 , , , cord-004862-yv76yvy5 211 17 S S NNP cord-004862-yv76yvy5 211 18 , , , cord-004862-yv76yvy5 211 19 and and CC cord-004862-yv76yvy5 211 20 T T NNP cord-004862-yv76yvy5 211 21 ( ( -LRB- cord-004862-yv76yvy5 211 22 neutral neutral JJ cord-004862-yv76yvy5 211 23 or or CC cord-004862-yv76yvy5 211 24 weakly weakly RB cord-004862-yv76yvy5 211 25 hydrophobic hydrophobic JJ cord-004862-yv76yvy5 211 26 ) ) -RRB- cord-004862-yv76yvy5 211 27 ; ; : cord-004862-yv76yvy5 211 28 Q Q NNP cord-004862-yv76yvy5 211 29 , , , cord-004862-yv76yvy5 211 30 N N NNP cord-004862-yv76yvy5 211 31 , , , cord-004862-yv76yvy5 211 32 E E NNP cord-004862-yv76yvy5 211 33 , , , cord-004862-yv76yvy5 211 34 and and CC cord-004862-yv76yvy5 211 35 D D NNP cord-004862-yv76yvy5 211 36 ( ( -LRB- cord-004862-yv76yvy5 211 37 acids acid NNS cord-004862-yv76yvy5 211 38 and and CC cord-004862-yv76yvy5 211 39 amides amide NNS cord-004862-yv76yvy5 211 40 ) ) -RRB- cord-004862-yv76yvy5 211 41 ; ; : cord-004862-yv76yvy5 211 42 H H NNP cord-004862-yv76yvy5 211 43 , , , cord-004862-yv76yvy5 211 44 K K NNP cord-004862-yv76yvy5 211 45 , , , cord-004862-yv76yvy5 211 46 and and CC cord-004862-yv76yvy5 211 47 R r NN cord-004862-yv76yvy5 211 48 ( ( -LRB- cord-004862-yv76yvy5 211 49 basic basic NNP cord-004862-yv76yvy5 211 50 ) ) -RRB- cord-004862-yv76yvy5 211 51 ; ; : cord-004862-yv76yvy5 211 52 L L NNP cord-004862-yv76yvy5 211 53 , , , cord-004862-yv76yvy5 211 54 I -PRON- PRP cord-004862-yv76yvy5 211 55 , , , cord-004862-yv76yvy5 211 56 V v NN cord-004862-yv76yvy5 211 57 , , , cord-004862-yv76yvy5 211 58 and and CC cord-004862-yv76yvy5 211 59 M M NNP cord-004862-yv76yvy5 211 60 ( ( -LRB- cord-004862-yv76yvy5 211 61 hydrophobic hydrophobic NNP cord-004862-yv76yvy5 211 62 ) ) -RRB- cord-004862-yv76yvy5 211 63 ; ; : cord-004862-yv76yvy5 211 64 F F NNP cord-004862-yv76yvy5 211 65 , , , cord-004862-yv76yvy5 211 66 Y Y NNP cord-004862-yv76yvy5 211 67 , , , cord-004862-yv76yvy5 211 68 and and CC cord-004862-yv76yvy5 211 69 W W NNP cord-004862-yv76yvy5 211 70 ( ( -LRB- cord-004862-yv76yvy5 211 71 aromatic aromatic JJ cord-004862-yv76yvy5 211 72 ) ) -RRB- cord-004862-yv76yvy5 211 73 ; ; : cord-004862-yv76yvy5 211 74 and and CC cord-004862-yv76yvy5 211 75 C. C. NNP cord-004862-yv76yvy5 212 1 In in IN cord-004862-yv76yvy5 212 2 contrast contrast NN cord-004862-yv76yvy5 212 3 , , , cord-004862-yv76yvy5 212 4 the the DT cord-004862-yv76yvy5 212 5 N n CD cord-004862-yv76yvy5 212 6 - - HYPH cord-004862-yv76yvy5 212 7 terminal terminal JJ cord-004862-yv76yvy5 212 8 portion portion NN cord-004862-yv76yvy5 212 9 of of IN cord-004862-yv76yvy5 212 10 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 212 11 is be VBZ cord-004862-yv76yvy5 212 12 not not RB cord-004862-yv76yvy5 212 13 highly highly RB cord-004862-yv76yvy5 212 14 conserved conserve VBN cord-004862-yv76yvy5 212 15 between between IN cord-004862-yv76yvy5 212 16 mammalian mammalian JJ cord-004862-yv76yvy5 212 17 orders order NNS cord-004862-yv76yvy5 212 18 . . . cord-004862-yv76yvy5 213 1 This this DT cord-004862-yv76yvy5 213 2 region region NN cord-004862-yv76yvy5 213 3 shows show VBZ cord-004862-yv76yvy5 213 4 almost almost RB cord-004862-yv76yvy5 213 5 no no DT cord-004862-yv76yvy5 213 6 similarity similarity NN cord-004862-yv76yvy5 213 7 between between IN cord-004862-yv76yvy5 213 8 rabbit rabbit NN cord-004862-yv76yvy5 213 9 and and CC cord-004862-yv76yvy5 213 10 human human JJ cord-004862-yv76yvy5 213 11 ( ( -LRB- cord-004862-yv76yvy5 213 12 sequence sequence NN cord-004862-yv76yvy5 213 13 between between IN cord-004862-yv76yvy5 213 14 nucleotide nucleotide JJ cord-004862-yv76yvy5 213 15 positions position NNS cord-004862-yv76yvy5 213 16 3 3 CD cord-004862-yv76yvy5 213 17 and and CC cord-004862-yv76yvy5 213 18 476 476 CD cord-004862-yv76yvy5 213 19 in in IN cord-004862-yv76yvy5 213 20 Fig Fig NNP cord-004862-yv76yvy5 213 21 . . . cord-004862-yv76yvy5 214 1 8 8 CD cord-004862-yv76yvy5 214 2 ; ; : cord-004862-yv76yvy5 214 3 Fig Fig NNP cord-004862-yv76yvy5 214 4 . . . cord-004862-yv76yvy5 214 5 9 9 CD cord-004862-yv76yvy5 214 6 ) ) -RRB- cord-004862-yv76yvy5 214 7 , , , cord-004862-yv76yvy5 214 8 and and CC cord-004862-yv76yvy5 215 1 the the DT cord-004862-yv76yvy5 215 2 comparison comparison NN cord-004862-yv76yvy5 215 3 between between IN cord-004862-yv76yvy5 215 4 rabbit rabbit NN cord-004862-yv76yvy5 215 5 and and CC cord-004862-yv76yvy5 215 6 mouse mouse NN cord-004862-yv76yvy5 215 7 shows show VBZ cord-004862-yv76yvy5 215 8 only only RB cord-004862-yv76yvy5 215 9 a a DT cord-004862-yv76yvy5 215 10 short short JJ cord-004862-yv76yvy5 215 11 segment segment NN cord-004862-yv76yvy5 215 12 of of IN cord-004862-yv76yvy5 215 13 matching match VBG cord-004862-yv76yvy5 215 14 sequence sequence NN cord-004862-yv76yvy5 215 15 at at IN cord-004862-yv76yvy5 215 16 the the DT cord-004862-yv76yvy5 215 17 5 5 CD cord-004862-yv76yvy5 215 18 ' ' NN cord-004862-yv76yvy5 215 19 end end NN cord-004862-yv76yvy5 215 20 ( ( -LRB- cord-004862-yv76yvy5 215 21 Figs fig NNS cord-004862-yv76yvy5 215 22 . . . cord-004862-yv76yvy5 215 23 8 8 CD cord-004862-yv76yvy5 215 24 and and CC cord-004862-yv76yvy5 215 25 9 9 CD cord-004862-yv76yvy5 215 26 ) ) -RRB- cord-004862-yv76yvy5 215 27 . . . cord-004862-yv76yvy5 216 1 The the DT cord-004862-yv76yvy5 216 2 dissimilarity dissimilarity NN cord-004862-yv76yvy5 216 3 of of IN cord-004862-yv76yvy5 216 4 the the DT cord-004862-yv76yvy5 216 5 sequences sequence NNS cord-004862-yv76yvy5 216 6 makes make VBZ cord-004862-yv76yvy5 216 7 it -PRON- PRP cord-004862-yv76yvy5 216 8 difficult difficult JJ cord-004862-yv76yvy5 216 9 to to TO cord-004862-yv76yvy5 216 10 assign assign VB cord-004862-yv76yvy5 216 11 a a DT cord-004862-yv76yvy5 216 12 start start NN cord-004862-yv76yvy5 216 13 point point NN cord-004862-yv76yvy5 216 14 to to IN cord-004862-yv76yvy5 216 15 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 216 16 . . . cord-004862-yv76yvy5 217 1 However however RB cord-004862-yv76yvy5 217 2 , , , cord-004862-yv76yvy5 217 3 an an DT cord-004862-yv76yvy5 217 4 ATG ATG NNP cord-004862-yv76yvy5 217 5 is be VBZ cord-004862-yv76yvy5 217 6 found find VBN cord-004862-yv76yvy5 217 7 in in IN cord-004862-yv76yvy5 217 8 the the DT cord-004862-yv76yvy5 217 9 rabbit rabbit NN cord-004862-yv76yvy5 217 10 , , , cord-004862-yv76yvy5 217 11 mouse mouse NN cord-004862-yv76yvy5 217 12 , , , cord-004862-yv76yvy5 217 13 and and CC cord-004862-yv76yvy5 217 14 rat rat NN cord-004862-yv76yvy5 217 15 sequences sequence NNS cord-004862-yv76yvy5 217 16 at at IN cord-004862-yv76yvy5 217 17 positions position NNS cord-004862-yv76yvy5 217 18 240 240 CD cord-004862-yv76yvy5 217 19 - - SYM cord-004862-yv76yvy5 217 20 242 242 CD cord-004862-yv76yvy5 217 21 of of IN cord-004862-yv76yvy5 217 22 Fig Fig NNP cord-004862-yv76yvy5 217 23 . . . cord-004862-yv76yvy5 217 24 8 8 CD cord-004862-yv76yvy5 218 1 ( ( -LRB- cord-004862-yv76yvy5 218 2 shown show VBN cord-004862-yv76yvy5 218 3 in in IN cord-004862-yv76yvy5 218 4 boldface boldface NN cord-004862-yv76yvy5 218 5 ) ) -RRB- cord-004862-yv76yvy5 218 6 . . . cord-004862-yv76yvy5 219 1 An an DT cord-004862-yv76yvy5 219 2 ATG ATG NNP cord-004862-yv76yvy5 219 3 is be VBZ cord-004862-yv76yvy5 219 4 found find VBN cord-004862-yv76yvy5 219 5 three three CD cord-004862-yv76yvy5 219 6 codons codon NNS cord-004862-yv76yvy5 219 7 downstream downstream JJ cord-004862-yv76yvy5 219 8 in in IN cord-004862-yv76yvy5 219 9 the the DT cord-004862-yv76yvy5 219 10 human human JJ cord-004862-yv76yvy5 219 11 L1 L1 NNP cord-004862-yv76yvy5 219 12 sequence sequence NN cord-004862-yv76yvy5 219 13 . . . cord-004862-yv76yvy5 220 1 Other other JJ cord-004862-yv76yvy5 220 2 ATG ATG NNP cord-004862-yv76yvy5 220 3 codons codon NNS cord-004862-yv76yvy5 220 4 are be VBP cord-004862-yv76yvy5 220 5 either either CC cord-004862-yv76yvy5 220 6 immediately immediately RB cord-004862-yv76yvy5 220 7 adjacent adjacent JJ cord-004862-yv76yvy5 220 8 ( ( -LRB- cord-004862-yv76yvy5 220 9 mouse mouse NN cord-004862-yv76yvy5 220 10 and and CC cord-004862-yv76yvy5 220 11 rat rat NN cord-004862-yv76yvy5 220 12 ) ) -RRB- cord-004862-yv76yvy5 220 13 or or CC cord-004862-yv76yvy5 220 14 are be VBP cord-004862-yv76yvy5 220 15 20 20 CD cord-004862-yv76yvy5 220 16 codons codon NNS cord-004862-yv76yvy5 220 17 upstream upstream JJ cord-004862-yv76yvy5 220 18 ( ( -LRB- cord-004862-yv76yvy5 220 19 rabbit rabbit NN cord-004862-yv76yvy5 220 20 , , , cord-004862-yv76yvy5 220 21 underlined underline VBN cord-004862-yv76yvy5 220 22 in in IN cord-004862-yv76yvy5 220 23 Fig Fig NNP cord-004862-yv76yvy5 220 24 . . . cord-004862-yv76yvy5 220 25 8) 8) NNP cord-004862-yv76yvy5 220 26 . . . cord-004862-yv76yvy5 221 1 The the DT cord-004862-yv76yvy5 221 2 ATG ATG NNP cord-004862-yv76yvy5 221 3 at at IN cord-004862-yv76yvy5 221 4 positions position NNS cord-004862-yv76yvy5 221 5 240 240 CD cord-004862-yv76yvy5 221 6 - - SYM cord-004862-yv76yvy5 221 7 242 242 CD cord-004862-yv76yvy5 221 8 has have VBZ cord-004862-yv76yvy5 221 9 been be VBN cord-004862-yv76yvy5 221 10 tentatively tentatively RB cord-004862-yv76yvy5 221 11 assigned assign VBN cord-004862-yv76yvy5 221 12 as as IN cord-004862-yv76yvy5 221 13 the the DT cord-004862-yv76yvy5 221 14 start start NN cord-004862-yv76yvy5 221 15 of of IN cord-004862-yv76yvy5 221 16 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 221 17 , , , cord-004862-yv76yvy5 221 18 and and CC cord-004862-yv76yvy5 221 19 the the DT cord-004862-yv76yvy5 221 20 codons codon NNS cord-004862-yv76yvy5 221 21 in in IN cord-004862-yv76yvy5 221 22 Fig Fig NNP cord-004862-yv76yvy5 221 23 . . . cord-004862-yv76yvy5 222 1 8 8 CD cord-004862-yv76yvy5 222 2 are be VBP cord-004862-yv76yvy5 222 3 numbered number VBN cord-004862-yv76yvy5 222 4 starting start VBG cord-004862-yv76yvy5 222 5 here here RB cord-004862-yv76yvy5 222 6 . . . cord-004862-yv76yvy5 223 1 This this DT cord-004862-yv76yvy5 223 2 is be VBZ cord-004862-yv76yvy5 223 3 71 71 CD cord-004862-yv76yvy5 223 4 codons codon NNS cord-004862-yv76yvy5 223 5 into into IN cord-004862-yv76yvy5 223 6 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 223 7 as as IN cord-004862-yv76yvy5 223 8 defined define VBN cord-004862-yv76yvy5 223 9 by by IN cord-004862-yv76yvy5 223 10 Loeb Loeb NNP cord-004862-yv76yvy5 223 11 et et NNP cord-004862-yv76yvy5 223 12 al al NNP cord-004862-yv76yvy5 223 13 . . . cord-004862-yv76yvy5 224 1 ( ( -LRB- cord-004862-yv76yvy5 224 2 1986 1986 CD cord-004862-yv76yvy5 224 3 ) ) -RRB- cord-004862-yv76yvy5 224 4 . . . cord-004862-yv76yvy5 225 1 Although although IN cord-004862-yv76yvy5 225 2 the the DT cord-004862-yv76yvy5 225 3 N n CD cord-004862-yv76yvy5 225 4 - - HYPH cord-004862-yv76yvy5 225 5 terminal terminal JJ cord-004862-yv76yvy5 225 6 half half NN cord-004862-yv76yvy5 225 7 of of IN cord-004862-yv76yvy5 225 8 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 225 9 differs differ VBZ cord-004862-yv76yvy5 225 10 among among IN cord-004862-yv76yvy5 225 11 rabbits rabbit NNS cord-004862-yv76yvy5 225 12 , , , cord-004862-yv76yvy5 225 13 mouse mouse NN cord-004862-yv76yvy5 225 14 , , , cord-004862-yv76yvy5 225 15 and and CC cord-004862-yv76yvy5 225 16 humans human NNS cord-004862-yv76yvy5 225 17 , , , cord-004862-yv76yvy5 225 18 it -PRON- PRP cord-004862-yv76yvy5 225 19 is be VBZ cord-004862-yv76yvy5 225 20 similar similar JJ cord-004862-yv76yvy5 225 21 between between IN cord-004862-yv76yvy5 225 22 the the DT cord-004862-yv76yvy5 225 23 two two CD cord-004862-yv76yvy5 225 24 rodents rodent NNS cord-004862-yv76yvy5 225 25 , , , cord-004862-yv76yvy5 225 26 mouse mouse NN cord-004862-yv76yvy5 225 27 and and CC cord-004862-yv76yvy5 225 28 rat rat NN cord-004862-yv76yvy5 225 29 . . . cord-004862-yv76yvy5 226 1 This this DT cord-004862-yv76yvy5 226 2 region region NN cord-004862-yv76yvy5 226 3 surrounds surround VBZ cord-004862-yv76yvy5 226 4 a a DT cord-004862-yv76yvy5 226 5 66-bp 66-bp CD cord-004862-yv76yvy5 226 6 tandemly tandemly NNP cord-004862-yv76yvy5 226 7 repeated repeat VBN cord-004862-yv76yvy5 226 8 sequence sequence NN cord-004862-yv76yvy5 226 9 in in IN cord-004862-yv76yvy5 226 10 L1Rn L1Rn NNP cord-004862-yv76yvy5 226 11 ( ( -LRB- cord-004862-yv76yvy5 226 12 Soares Soares NNP cord-004862-yv76yvy5 226 13 et et NNP cord-004862-yv76yvy5 226 14 al al NNP cord-004862-yv76yvy5 226 15 . . . cord-004862-yv76yvy5 226 16 1985 1985 CD cord-004862-yv76yvy5 226 17 ; ; : cord-004862-yv76yvy5 226 18 D'Ambrosio D'Ambrosio NNP cord-004862-yv76yvy5 226 19 et et NNP cord-004862-yv76yvy5 226 20 al al NNP cord-004862-yv76yvy5 226 21 . . NNP cord-004862-yv76yvy5 226 22 1986 1986 CD cord-004862-yv76yvy5 226 23 ) ) -RRB- cord-004862-yv76yvy5 226 24 and and CC cord-004862-yv76yvy5 226 25 contains contain VBZ cord-004862-yv76yvy5 226 26 several several JJ cord-004862-yv76yvy5 226 27 in in IN cord-004862-yv76yvy5 226 28 - - HYPH cord-004862-yv76yvy5 226 29 frame frame NN cord-004862-yv76yvy5 226 30 stop stop NN cord-004862-yv76yvy5 226 31 codons codon NNS cord-004862-yv76yvy5 226 32 in in IN cord-004862-yv76yvy5 226 33 L1Rn l1rn XX cord-004862-yv76yvy5 227 1 ( ( -LRB- cord-004862-yv76yvy5 227 2 Fig Fig NNP cord-004862-yv76yvy5 227 3 . . . cord-004862-yv76yvy5 227 4 8) 8) NNP cord-004862-yv76yvy5 227 5 . . . cord-004862-yv76yvy5 228 1 It -PRON- PRP cord-004862-yv76yvy5 228 2 is be VBZ cord-004862-yv76yvy5 228 3 possible possible JJ cord-004862-yv76yvy5 228 4 that that IN cord-004862-yv76yvy5 228 5 the the DT cord-004862-yv76yvy5 228 6 coding code VBG cord-004862-yv76yvy5 228 7 function function NN cord-004862-yv76yvy5 228 8 of of IN cord-004862-yv76yvy5 228 9 this this DT cord-004862-yv76yvy5 228 10 region region NN cord-004862-yv76yvy5 228 11 has have VBZ cord-004862-yv76yvy5 228 12 been be VBN cord-004862-yv76yvy5 228 13 lost lose VBN cord-004862-yv76yvy5 228 14 in in IN cord-004862-yv76yvy5 228 15 L1Rn l1rn CD cord-004862-yv76yvy5 228 16 . . . cord-004862-yv76yvy5 229 1 The the DT cord-004862-yv76yvy5 229 2 N N NNP cord-004862-yv76yvy5 229 3 - - HYPH cord-004862-yv76yvy5 229 4 terminal terminal JJ cord-004862-yv76yvy5 229 5 half half NN cord-004862-yv76yvy5 229 6 of of IN cord-004862-yv76yvy5 229 7 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 229 8 from from IN cord-004862-yv76yvy5 229 9 the the DT cord-004862-yv76yvy5 229 10 rabbit rabbit NN cord-004862-yv76yvy5 229 11 L l NN cord-004862-yv76yvy5 229 12 1 1 CD cord-004862-yv76yvy5 229 13 sequence sequence NN cord-004862-yv76yvy5 229 14 is be VBZ cord-004862-yv76yvy5 229 15 related relate VBN cord-004862-yv76yvy5 229 16 to to IN cord-004862-yv76yvy5 229 17 type type NN cord-004862-yv76yvy5 229 18 II II NNP cord-004862-yv76yvy5 229 19 cytoskeletal cytoskeletal JJ cord-004862-yv76yvy5 229 20 keratin keratin NN cord-004862-yv76yvy5 229 21 . . . cord-004862-yv76yvy5 230 1 Protein protein NN cord-004862-yv76yvy5 230 2 sequence sequence NN cord-004862-yv76yvy5 230 3 databanks databank NNS cord-004862-yv76yvy5 230 4 were be VBD cord-004862-yv76yvy5 230 5 searched search VBN cord-004862-yv76yvy5 230 6 using use VBG cord-004862-yv76yvy5 230 7 the the DT cord-004862-yv76yvy5 230 8 FASTp fastp NN cord-004862-yv76yvy5 230 9 program program NN cord-004862-yv76yvy5 230 10 ( ( -LRB- cord-004862-yv76yvy5 230 11 Lipman Lipman NNP cord-004862-yv76yvy5 230 12 and and CC cord-004862-yv76yvy5 230 13 Pearson Pearson NNP cord-004862-yv76yvy5 230 14 1985 1985 CD cord-004862-yv76yvy5 230 15 ) ) -RRB- cord-004862-yv76yvy5 230 16 , , , cord-004862-yv76yvy5 230 17 and and CC cord-004862-yv76yvy5 230 18 a a DT cord-004862-yv76yvy5 230 19 significant significant JJ cord-004862-yv76yvy5 230 20 match match NN cord-004862-yv76yvy5 230 21 was be VBD cord-004862-yv76yvy5 230 22 found find VBN cord-004862-yv76yvy5 230 23 with with IN cord-004862-yv76yvy5 230 24 type type NN cord-004862-yv76yvy5 230 25 II II NNP cord-004862-yv76yvy5 230 26 cytoskeletal cytoskeletal JJ cord-004862-yv76yvy5 230 27 keratin keratin NN cord-004862-yv76yvy5 230 28 . . . cord-004862-yv76yvy5 231 1 The the DT cord-004862-yv76yvy5 231 2 region region NN cord-004862-yv76yvy5 231 3 of of IN cord-004862-yv76yvy5 231 4 L1Oc L1Oc NNP cord-004862-yv76yvy5 231 5 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 231 6 that that IN cord-004862-yv76yvy5 231 7 matches match VBZ cord-004862-yv76yvy5 231 8 with with IN cord-004862-yv76yvy5 231 9 keratin keratin NN cord-004862-yv76yvy5 231 10 , , , cord-004862-yv76yvy5 231 11 along along IN cord-004862-yv76yvy5 231 12 with with IN cord-004862-yv76yvy5 231 13 the the DT cord-004862-yv76yvy5 231 14 percent percent NN cord-004862-yv76yvy5 231 15 amino amino NN cord-004862-yv76yvy5 231 16 acid acid NN cord-004862-yv76yvy5 231 17 identity identity NN cord-004862-yv76yvy5 231 18 , , , cord-004862-yv76yvy5 231 19 is be VBZ cord-004862-yv76yvy5 231 20 shown show VBN cord-004862-yv76yvy5 231 21 in in IN cord-004862-yv76yvy5 231 22 Fig Fig NNP cord-004862-yv76yvy5 231 23 . . NNP cord-004862-yv76yvy5 231 24 9 9 CD cord-004862-yv76yvy5 231 25 , , , cord-004862-yv76yvy5 231 26 and and CC cord-004862-yv76yvy5 231 27 the the DT cord-004862-yv76yvy5 231 28 alignment alignment NN cord-004862-yv76yvy5 231 29 with with IN cord-004862-yv76yvy5 231 30 the the DT cord-004862-yv76yvy5 231 31 human human JJ cord-004862-yv76yvy5 231 32 67 67 CD cord-004862-yv76yvy5 231 33 kDa kDa NNP cord-004862-yv76yvy5 231 34 type type NN cord-004862-yv76yvy5 231 35 II II NNP cord-004862-yv76yvy5 231 36 keratin keratin NN cord-004862-yv76yvy5 231 37 ) ) -RRB- cord-004862-yv76yvy5 231 38 is be VBZ cord-004862-yv76yvy5 231 39 shown show VBN cord-004862-yv76yvy5 231 40 in in IN cord-004862-yv76yvy5 231 41 Fig Fig NNP cord-004862-yv76yvy5 231 42 . . . cord-004862-yv76yvy5 232 1 10 10 CD cord-004862-yv76yvy5 232 2 . . . cord-004862-yv76yvy5 233 1 The the DT cord-004862-yv76yvy5 233 2 sequences sequence NNS cord-004862-yv76yvy5 233 3 align align VBP cord-004862-yv76yvy5 233 4 OVer over IN cord-004862-yv76yvy5 233 5 a a DT cord-004862-yv76yvy5 233 6 156-amino 156-amino CD cord-004862-yv76yvy5 233 7 acid acid NN cord-004862-yv76yvy5 233 8 region region NN cord-004862-yv76yvy5 233 9 , , , cord-004862-yv76yvy5 233 10 with with IN cord-004862-yv76yvy5 233 11 an an DT cord-004862-yv76yvy5 233 12 average average NN cord-004862-yv76yvy5 233 13 of of IN cord-004862-yv76yvy5 233 14 20.5 20.5 CD cord-004862-yv76yvy5 233 15 % % NN cord-004862-yv76yvy5 233 16 identity identity NN cord-004862-yv76yvy5 233 17 . . . cord-004862-yv76yvy5 234 1 The the DT cord-004862-yv76yvy5 234 2 segment segment NN cord-004862-yv76yvy5 234 3 between between IN cord-004862-yv76yvy5 234 4 amino amino NN cord-004862-yv76yvy5 234 5 acid acid NN cord-004862-yv76yvy5 234 6 positions position NNS cord-004862-yv76yvy5 234 7 95 95 CD cord-004862-yv76yvy5 234 8 and and CC cord-004862-yv76yvy5 234 9 126 126 CD cord-004862-yv76yvy5 235 1 ofLIOc ofLIOc NNP cord-004862-yv76yvy5 236 1 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 236 2 is be VBZ cord-004862-yv76yvy5 236 3 most most RBS cord-004862-yv76yvy5 236 4 similar similar JJ cord-004862-yv76yvy5 236 5 to to IN cord-004862-yv76yvy5 236 6 type type NN cord-004862-yv76yvy5 236 7 II II NNP cord-004862-yv76yvy5 236 8 keratin keratin NN cord-004862-yv76yvy5 236 9 ; ; : cord-004862-yv76yvy5 236 10 this this DT cord-004862-yv76yvy5 236 11 segment segment NN cord-004862-yv76yvy5 236 12 contains contain VBZ cord-004862-yv76yvy5 236 13 identical identical JJ cord-004862-yv76yvy5 236 14 amino amino JJ cord-004862-yv76yvy5 236 15 acids acid NNS cord-004862-yv76yvy5 236 16 at at IN cord-004862-yv76yvy5 236 17 32 32 CD cord-004862-yv76yvy5 236 18 % % NN cord-004862-yv76yvy5 236 19 of of IN cord-004862-yv76yvy5 236 20 the the DT cord-004862-yv76yvy5 236 21 positions position NNS cord-004862-yv76yvy5 236 22 . . . cord-004862-yv76yvy5 237 1 The the DT cord-004862-yv76yvy5 237 2 similarity similarity NN cord-004862-yv76yvy5 237 3 between between IN cord-004862-yv76yvy5 237 4 the the DT cord-004862-yv76yvy5 237 5 N n CD cord-004862-yv76yvy5 237 6 - - HYPH cord-004862-yv76yvy5 237 7 terminal terminal JJ cord-004862-yv76yvy5 237 8 half half NN cord-004862-yv76yvy5 237 9 of of IN cord-004862-yv76yvy5 237 10 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 237 11 from from IN cord-004862-yv76yvy5 237 12 L10c L10c NNP cord-004862-yv76yvy5 237 13 and and CC cord-004862-yv76yvy5 237 14 type type NN cord-004862-yv76yvy5 237 15 II II NNP cord-004862-yv76yvy5 237 16 cytoskeletal cytoskeletal JJ cord-004862-yv76yvy5 237 17 keratin keratin NN cord-004862-yv76yvy5 237 18 is be VBZ cord-004862-yv76yvy5 237 19 statistically statistically RB cord-004862-yv76yvy5 237 20 significant significant JJ cord-004862-yv76yvy5 237 21 . . . cord-004862-yv76yvy5 238 1 The the DT cord-004862-yv76yvy5 238 2 sequence sequence NN cord-004862-yv76yvy5 238 3 of of IN cord-004862-yv76yvy5 238 4 the the DT cord-004862-yv76yvy5 238 5 type type NN cord-004862-yv76yvy5 238 6 II II NNP cord-004862-yv76yvy5 238 7 keratin keratin NN cord-004862-yv76yvy5 238 8 was be VBD cord-004862-yv76yvy5 238 9 scrambled scramble VBN cord-004862-yv76yvy5 238 10 into into IN cord-004862-yv76yvy5 238 11 20 20 CD cord-004862-yv76yvy5 238 12 different different JJ cord-004862-yv76yvy5 238 13 sequences sequence NNS cord-004862-yv76yvy5 238 14 and and CC cord-004862-yv76yvy5 238 15 aligned align VBN cord-004862-yv76yvy5 238 16 with with IN cord-004862-yv76yvy5 238 17 the the DT cord-004862-yv76yvy5 238 18 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 238 19 sequence sequence NN cord-004862-yv76yvy5 238 20 to to TO cord-004862-yv76yvy5 238 21 generate generate VB cord-004862-yv76yvy5 238 22 an an DT cord-004862-yv76yvy5 238 23 average average JJ cord-004862-yv76yvy5 238 24 match match NN cord-004862-yv76yvy5 238 25 score score NN cord-004862-yv76yvy5 238 26 . . . cord-004862-yv76yvy5 239 1 The the DT cord-004862-yv76yvy5 239 2 match match NN cord-004862-yv76yvy5 239 3 score score NN cord-004862-yv76yvy5 239 4 with with IN cord-004862-yv76yvy5 239 5 the the DT cord-004862-yv76yvy5 239 6 true true JJ cord-004862-yv76yvy5 239 7 keratin keratin NN cord-004862-yv76yvy5 239 8 sequence sequence NN cord-004862-yv76yvy5 239 9 is be VBZ cord-004862-yv76yvy5 239 10 13 13 CD cord-004862-yv76yvy5 239 11 standard standard JJ cord-004862-yv76yvy5 239 12 deviations deviation NNS cord-004862-yv76yvy5 239 13 above above IN cord-004862-yv76yvy5 239 14 the the DT cord-004862-yv76yvy5 239 15 average average JJ cord-004862-yv76yvy5 239 16 match match NN cord-004862-yv76yvy5 239 17 score score NN cord-004862-yv76yvy5 239 18 with with IN cord-004862-yv76yvy5 239 19 the the DT cord-004862-yv76yvy5 239 20 scrambled scramble VBN cord-004862-yv76yvy5 239 21 sequences sequence NNS cord-004862-yv76yvy5 239 22 ; ; : cord-004862-yv76yvy5 239 23 a a DT cord-004862-yv76yvy5 239 24 difference difference NN cord-004862-yv76yvy5 239 25 of of IN cord-004862-yv76yvy5 239 26 10 10 CD cord-004862-yv76yvy5 239 27 standard standard JJ cord-004862-yv76yvy5 239 28 deviations deviation NNS cord-004862-yv76yvy5 239 29 in in IN cord-004862-yv76yvy5 239 30 this this DT cord-004862-yv76yvy5 239 31 test test NN cord-004862-yv76yvy5 239 32 is be VBZ cord-004862-yv76yvy5 239 33 an an DT cord-004862-yv76yvy5 239 34 indicator indicator NN cord-004862-yv76yvy5 239 35 of of IN cord-004862-yv76yvy5 239 36 a a DT cord-004862-yv76yvy5 239 37 significant significant JJ cord-004862-yv76yvy5 239 38 evolutionary evolutionary JJ cord-004862-yv76yvy5 239 39 relationship relationship NN cord-004862-yv76yvy5 239 40 ( ( -LRB- cord-004862-yv76yvy5 239 41 Lipman Lipman NNP cord-004862-yv76yvy5 239 42 and and CC cord-004862-yv76yvy5 239 43 Pearson Pearson NNP cord-004862-yv76yvy5 239 44 1985 1985 CD cord-004862-yv76yvy5 239 45 ) ) -RRB- cord-004862-yv76yvy5 239 46 . . . cord-004862-yv76yvy5 240 1 Although although IN cord-004862-yv76yvy5 240 2 statistical statistical JJ cord-004862-yv76yvy5 240 3 significance significance NN cord-004862-yv76yvy5 240 4 does do VBZ cord-004862-yv76yvy5 240 5 not not RB cord-004862-yv76yvy5 240 6 establish establish VB cord-004862-yv76yvy5 240 7 biological biological JJ cord-004862-yv76yvy5 240 8 significance significance NN cord-004862-yv76yvy5 240 9 , , , cord-004862-yv76yvy5 240 10 it -PRON- PRP cord-004862-yv76yvy5 240 11 is be VBZ cord-004862-yv76yvy5 240 12 helpful helpful JJ cord-004862-yv76yvy5 240 13 to to TO cord-004862-yv76yvy5 240 14 compare compare VB cord-004862-yv76yvy5 240 15 this this DT cord-004862-yv76yvy5 240 16 match match NN cord-004862-yv76yvy5 240 17 with with IN cord-004862-yv76yvy5 240 18 that that DT cord-004862-yv76yvy5 240 19 of of IN cord-004862-yv76yvy5 240 20 a a DT cord-004862-yv76yvy5 240 21 part part NN cord-004862-yv76yvy5 240 22 of of IN cord-004862-yv76yvy5 240 23 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 240 24 with with IN cord-004862-yv76yvy5 240 25 reverse reverse JJ cord-004862-yv76yvy5 240 26 transcriptases transcriptase NNS cord-004862-yv76yvy5 240 27 whose whose WP$ cord-004862-yv76yvy5 240 28 similarity similarity NN cord-004862-yv76yvy5 240 29 has have VBZ cord-004862-yv76yvy5 240 30 been be VBN cord-004862-yv76yvy5 240 31 cited cite VBN cord-004862-yv76yvy5 240 32 as as IN cord-004862-yv76yvy5 240 33 significant significant JJ cord-004862-yv76yvy5 240 34 in in IN cord-004862-yv76yvy5 240 35 the the DT cord-004862-yv76yvy5 240 36 past past NN cord-004862-yv76yvy5 241 1 ( ( -LRB- cord-004862-yv76yvy5 241 2 Hattori Hattori NNP cord-004862-yv76yvy5 241 3 et et NNP cord-004862-yv76yvy5 241 4 al al NNP cord-004862-yv76yvy5 241 5 . . . cord-004862-yv76yvy5 242 1 1986 1986 CD cord-004862-yv76yvy5 242 2 ; ; : cord-004862-yv76yvy5 242 3 Loeb Loeb NNP cord-004862-yv76yvy5 242 4 et et NNP cord-004862-yv76yvy5 242 5 al al NNP cord-004862-yv76yvy5 242 6 . . NNP cord-004862-yv76yvy5 242 7 1986 1986 CD cord-004862-yv76yvy5 242 8 ) ) -RRB- cord-004862-yv76yvy5 243 1 9 9 CD cord-004862-yv76yvy5 244 1 The the DT cord-004862-yv76yvy5 244 2 alignment alignment NN cord-004862-yv76yvy5 244 3 between between IN cord-004862-yv76yvy5 244 4 the the DT cord-004862-yv76yvy5 244 5 L1Md L1Md NNP cord-004862-yv76yvy5 244 6 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 244 7 sequence sequence NN cord-004862-yv76yvy5 244 8 and and CC cord-004862-yv76yvy5 244 9 the the DT cord-004862-yv76yvy5 244 10 sequence sequence NN cord-004862-yv76yvy5 244 11 of of IN cord-004862-yv76yvy5 244 12 reverse reverse JJ cord-004862-yv76yvy5 244 13 transcriptase transcriptase NN cord-004862-yv76yvy5 244 14 from from IN cord-004862-yv76yvy5 244 15 Moloney Moloney NNP cord-004862-yv76yvy5 244 16 murine murine JJ cord-004862-yv76yvy5 244 17 leukemia leukemia NN cord-004862-yv76yvy5 244 18 virus virus NN cord-004862-yv76yvy5 244 19 shows show VBZ cord-004862-yv76yvy5 244 20 17.5 17.5 CD cord-004862-yv76yvy5 244 21 % % NN cord-004862-yv76yvy5 244 22 amino amino NN cord-004862-yv76yvy5 244 23 acid acid NN cord-004862-yv76yvy5 244 24 identity identity NN cord-004862-yv76yvy5 244 25 , , , cord-004862-yv76yvy5 244 26 whereas whereas IN cord-004862-yv76yvy5 244 27 the the DT cord-004862-yv76yvy5 244 28 alignment alignment NN cord-004862-yv76yvy5 244 29 between between IN cord-004862-yv76yvy5 244 30 L1Oc L1Oc NNP cord-004862-yv76yvy5 244 31 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 244 32 and and CC cord-004862-yv76yvy5 244 33 type type NN cord-004862-yv76yvy5 244 34 II II NNP cord-004862-yv76yvy5 244 35 keratin keratin NN cord-004862-yv76yvy5 244 36 shows show VBZ cord-004862-yv76yvy5 244 37 20.5 20.5 CD cord-004862-yv76yvy5 244 38 % % NN cord-004862-yv76yvy5 244 39 identity identity NN cord-004862-yv76yvy5 244 40 . . . cord-004862-yv76yvy5 245 1 It -PRON- PRP cord-004862-yv76yvy5 245 2 is be VBZ cord-004862-yv76yvy5 245 3 apparent apparent JJ cord-004862-yv76yvy5 245 4 that that IN cord-004862-yv76yvy5 245 5 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 245 6 of of IN cord-004862-yv76yvy5 245 7 the the DT cord-004862-yv76yvy5 245 8 rabbit rabbit NN cord-004862-yv76yvy5 245 9 LI LI NNP cord-004862-yv76yvy5 245 10 contains contain VBZ cord-004862-yv76yvy5 245 11 a a DT cord-004862-yv76yvy5 245 12 region region NN cord-004862-yv76yvy5 245 13 related relate VBN cord-004862-yv76yvy5 245 14 in in IN cord-004862-yv76yvy5 245 15 sequence sequence NN cord-004862-yv76yvy5 245 16 to to IN cord-004862-yv76yvy5 245 17 type type NN cord-004862-yv76yvy5 245 18 II II NNP cord-004862-yv76yvy5 245 19 cytoskeletal cytoskeletal JJ cord-004862-yv76yvy5 245 20 keratin keratin NN cord-004862-yv76yvy5 245 21 . . . cord-004862-yv76yvy5 246 1 The the DT cord-004862-yv76yvy5 246 2 propagation propagation NN cord-004862-yv76yvy5 246 3 of of IN cord-004862-yv76yvy5 246 4 L1 L1 NNP cord-004862-yv76yvy5 246 5 repeats repeat VBZ cord-004862-yv76yvy5 246 6 probably probably RB cord-004862-yv76yvy5 246 7 has have VBZ cord-004862-yv76yvy5 246 8 occurred occur VBN cord-004862-yv76yvy5 246 9 independently independently RB cord-004862-yv76yvy5 246 10 in in IN cord-004862-yv76yvy5 246 11 different different JJ cord-004862-yv76yvy5 246 12 mammalian mammalian JJ cord-004862-yv76yvy5 246 13 gehomes gehome NNS cord-004862-yv76yvy5 246 14 . . . cord-004862-yv76yvy5 247 1 Although although IN cord-004862-yv76yvy5 247 2 the the DT cord-004862-yv76yvy5 247 3 L1 L1 NNP cord-004862-yv76yvy5 247 4 repeats repeat VBZ cord-004862-yv76yvy5 247 5 from from IN cord-004862-yv76yvy5 247 6 lagomorphs lagomorph NNS cord-004862-yv76yvy5 247 7 , , , cord-004862-yv76yvy5 247 8 rodents rodent NNS cord-004862-yv76yvy5 247 9 , , , cord-004862-yv76yvy5 247 10 and and CC cord-004862-yv76yvy5 247 11 primates primate NNS cord-004862-yv76yvy5 247 12 are be VBP cord-004862-yv76yvy5 247 13 similar similar JJ cord-004862-yv76yvy5 247 14 in in IN cord-004862-yv76yvy5 247 15 size size NN cord-004862-yv76yvy5 247 16 and and CC cord-004862-yv76yvy5 247 17 sequence sequence NN cord-004862-yv76yvy5 247 18 organization organization NN cord-004862-yv76yvy5 247 19 , , , cord-004862-yv76yvy5 247 20 the the DT cord-004862-yv76yvy5 247 21 5 5 CD cord-004862-yv76yvy5 247 22 ' ' '' cord-004862-yv76yvy5 247 23 and and CC cord-004862-yv76yvy5 247 24 3 3 CD cord-004862-yv76yvy5 247 25 ' ' POS cord-004862-yv76yvy5 247 26 ends end NNS cord-004862-yv76yvy5 247 27 are be VBP cord-004862-yv76yvy5 247 28 distinctive distinctive JJ cord-004862-yv76yvy5 247 29 ( ( -LRB- cord-004862-yv76yvy5 247 30 summarized summarize VBN cord-004862-yv76yvy5 247 31 in in IN cord-004862-yv76yvy5 247 32 Fig Fig NNP cord-004862-yv76yvy5 247 33 . . NNP cord-004862-yv76yvy5 247 34 11 11 CD cord-004862-yv76yvy5 247 35 ) ) -RRB- cord-004862-yv76yvy5 247 36 . . . cord-004862-yv76yvy5 248 1 Also also RB cord-004862-yv76yvy5 248 2 , , , cord-004862-yv76yvy5 248 3 the the DT cord-004862-yv76yvy5 248 4 LI LI NNP cord-004862-yv76yvy5 248 5 repeats repeat VBZ cord-004862-yv76yvy5 248 6 I -PRON- PRP cord-004862-yv76yvy5 248 7 _SP cord-004862-yv76yvy5 249 1 I -PRON- PRP cord-004862-yv76yvy5 249 2 _SP cord-004862-yv76yvy5 250 1 I -PRON- PRP cord-004862-yv76yvy5 250 2 _SP cord-004862-yv76yvy5 251 1 I -PRON- PRP cord-004862-yv76yvy5 251 2 _SP cord-004862-yv76yvy5 252 1 I -PRON- PRP cord-004862-yv76yvy5 252 2 _SP cord-004862-yv76yvy5 253 1 I -PRON- PRP cord-004862-yv76yvy5 253 2 _SP cord-004862-yv76yvy5 254 1 I -PRON- PRP cord-004862-yv76yvy5 254 2 _SP cord-004862-yv76yvy5 255 1 I -PRON- PRP cord-004862-yv76yvy5 255 2 are be VBP cord-004862-yv76yvy5 255 3 located locate VBN cord-004862-yv76yvy5 255 4 in in IN cord-004862-yv76yvy5 255 5 different different JJ cord-004862-yv76yvy5 255 6 positions position NNS cord-004862-yv76yvy5 255 7 in in IN cord-004862-yv76yvy5 255 8 orthologous orthologous JJ cord-004862-yv76yvy5 255 9 regions region NNS cord-004862-yv76yvy5 255 10 of of IN cord-004862-yv76yvy5 255 11 chromosomes chromosome NNS cord-004862-yv76yvy5 255 12 , , , cord-004862-yv76yvy5 255 13 specifically specifically RB cord-004862-yv76yvy5 255 14 the the DT cord-004862-yv76yvy5 255 15 B B NNP cord-004862-yv76yvy5 255 16 - - HYPH cord-004862-yv76yvy5 255 17 like like JJ cord-004862-yv76yvy5 255 18 globin globin NN cord-004862-yv76yvy5 255 19 gene gene NN cord-004862-yv76yvy5 255 20 cluster cluster NN cord-004862-yv76yvy5 255 21 of of IN cord-004862-yv76yvy5 255 22 rabbits rabbit NNS cord-004862-yv76yvy5 255 23 and and CC cord-004862-yv76yvy5 255 24 humans human NNS cord-004862-yv76yvy5 255 25 ( ( -LRB- cord-004862-yv76yvy5 256 1 Margot.el Margot.el NNP cord-004862-yv76yvy5 256 2 al al NNP cord-004862-yv76yvy5 256 3 . . . cord-004862-yv76yvy5 257 1 1989 1989 LS cord-004862-yv76yvy5 257 2 ) ) -RRB- cord-004862-yv76yvy5 257 3 and and CC cord-004862-yv76yvy5 257 4 mice mouse NNS cord-004862-yv76yvy5 258 1 ( ( -LRB- cord-004862-yv76yvy5 258 2 Shehee Shehee NNP cord-004862-yv76yvy5 258 3 et et NNP cord-004862-yv76yvy5 258 4 al al NNP cord-004862-yv76yvy5 258 5 . . NNP cord-004862-yv76yvy5 258 6 1989 1989 CD cord-004862-yv76yvy5 258 7 ) ) -RRB- cord-004862-yv76yvy5 258 8 . . . cord-004862-yv76yvy5 259 1 Because because IN cord-004862-yv76yvy5 259 2 the the DT cord-004862-yv76yvy5 259 3 contemporary contemporary JJ cord-004862-yv76yvy5 259 4 /3-like /3-like NNP cord-004862-yv76yvy5 259 5 globin globin NN cord-004862-yv76yvy5 259 6 gene gene NN cord-004862-yv76yvy5 259 7 clusters cluster NNS cord-004862-yv76yvy5 259 8 are be VBP cord-004862-yv76yvy5 259 9 descended descend VBN cord-004862-yv76yvy5 259 10 from from IN cord-004862-yv76yvy5 259 11 a a DT cord-004862-yv76yvy5 259 12 preexisting preexist VBG cord-004862-yv76yvy5 259 13 gene gene NN cord-004862-yv76yvy5 259 14 cluster cluster NN cord-004862-yv76yvy5 259 15 in in IN cord-004862-yv76yvy5 259 16 the the DT cord-004862-yv76yvy5 259 17 last last JJ cord-004862-yv76yvy5 259 18 common common JJ cord-004862-yv76yvy5 259 19 ancestor ancestor NN cord-004862-yv76yvy5 259 20 , , , cord-004862-yv76yvy5 259 21 the the DT cord-004862-yv76yvy5 259 22 presence presence NN cord-004862-yv76yvy5 259 23 of of IN cord-004862-yv76yvy5 259 24 L1 L1 NNP cord-004862-yv76yvy5 259 25 repeats repeat VBZ cord-004862-yv76yvy5 259 26 at at IN cord-004862-yv76yvy5 259 27 different different JJ cord-004862-yv76yvy5 259 28 positions position NNS cord-004862-yv76yvy5 259 29 in in IN cord-004862-yv76yvy5 259 30 different different JJ cord-004862-yv76yvy5 259 31 species specie NNS cord-004862-yv76yvy5 259 32 indicates indicate VBZ cord-004862-yv76yvy5 259 33 that that IN cord-004862-yv76yvy5 259 34 the the DT cord-004862-yv76yvy5 259 35 L1 L1 NNP cord-004862-yv76yvy5 259 36 repeats repeat NNS cord-004862-yv76yvy5 259 37 have have VBP cord-004862-yv76yvy5 259 38 integrated integrate VBN cord-004862-yv76yvy5 259 39 independently independently RB cord-004862-yv76yvy5 259 40 into into IN cord-004862-yv76yvy5 259 41 these these DT cord-004862-yv76yvy5 259 42 gene gene NN cord-004862-yv76yvy5 259 43 clusters cluster NNS cord-004862-yv76yvy5 259 44 ( ( -LRB- cord-004862-yv76yvy5 259 45 and and CC cord-004862-yv76yvy5 259 46 probably probably RB cord-004862-yv76yvy5 259 47 the the DT cord-004862-yv76yvy5 259 48 whole whole JJ cord-004862-yv76yvy5 259 49 genome genome NN cord-004862-yv76yvy5 259 50 ) ) -RRB- cord-004862-yv76yvy5 259 51 is be VBZ cord-004862-yv76yvy5 259 52 each each DT cord-004862-yv76yvy5 259 53 species specie NNS cord-004862-yv76yvy5 259 54 . . . cord-004862-yv76yvy5 260 1 It -PRON- PRP cord-004862-yv76yvy5 260 2 is be VBZ cord-004862-yv76yvy5 260 3 noteworthy noteworthy JJ cord-004862-yv76yvy5 260 4 , , , cord-004862-yv76yvy5 260 5 therefore therefore RB cord-004862-yv76yvy5 260 6 , , , cord-004862-yv76yvy5 260 7 that that IN cord-004862-yv76yvy5 260 8 the the DT cord-004862-yv76yvy5 260 9 structure structure NN cord-004862-yv76yvy5 260 10 of of IN cord-004862-yv76yvy5 260 11 the the DT cord-004862-yv76yvy5 260 12 population population NN cord-004862-yv76yvy5 260 13 of of IN cord-004862-yv76yvy5 260 14 L1 L1 NNP cord-004862-yv76yvy5 260 15 repeats repeat VBZ cord-004862-yv76yvy5 260 16 is be VBZ cord-004862-yv76yvy5 260 17 quite quite RB cord-004862-yv76yvy5 260 18 similar similar JJ cord-004862-yv76yvy5 260 19 in in IN cord-004862-yv76yvy5 260 20 several several JJ cord-004862-yv76yvy5 260 21 mammals mammal NNS cord-004862-yv76yvy5 260 22 . . . cord-004862-yv76yvy5 261 1 Most Most JJS cord-004862-yv76yvy5 261 2 members member NNS cord-004862-yv76yvy5 261 3 of of IN cord-004862-yv76yvy5 261 4 the the DT cord-004862-yv76yvy5 261 5 L1 L1 NNP cord-004862-yv76yvy5 261 6 repeat repeat NN cord-004862-yv76yvy5 261 7 family family NN cord-004862-yv76yvy5 261 8 in in IN cord-004862-yv76yvy5 261 9 rabbits rabbit NNS cord-004862-yv76yvy5 261 10 ( ( -LRB- cord-004862-yv76yvy5 261 11 this this DT cord-004862-yv76yvy5 261 12 paper paper NN cord-004862-yv76yvy5 261 13 ) ) -RRB- cord-004862-yv76yvy5 261 14 , , , cord-004862-yv76yvy5 261 15 mouse mouse NN cord-004862-yv76yvy5 261 16 ( ( -LRB- cord-004862-yv76yvy5 261 17 Voliva Voliva NNP cord-004862-yv76yvy5 261 18 et et FW cord-004862-yv76yvy5 261 19 al al NNP cord-004862-yv76yvy5 261 20 . . . cord-004862-yv76yvy5 261 21 1983 1983 CD cord-004862-yv76yvy5 261 22 ) ) -RRB- cord-004862-yv76yvy5 261 23 , , , cord-004862-yv76yvy5 261 24 and and CC cord-004862-yv76yvy5 261 25 monkeys monkey NNS cord-004862-yv76yvy5 261 26 ( ( -LRB- cord-004862-yv76yvy5 261 27 Grimaldi Grimaldi NNP cord-004862-yv76yvy5 261 28 et et NNP cord-004862-yv76yvy5 261 29 al al NNP cord-004862-yv76yvy5 261 30 . . . cord-004862-yv76yvy5 261 31 1984 1984 CD cord-004862-yv76yvy5 261 32 ) ) -RRB- cord-004862-yv76yvy5 261 33 are be VBP cord-004862-yv76yvy5 261 34 truncated truncate VBN cord-004862-yv76yvy5 261 35 from from IN cord-004862-yv76yvy5 261 36 the the DT cord-004862-yv76yvy5 261 37 5 5 CD cord-004862-yv76yvy5 261 38 ' ' NN cord-004862-yv76yvy5 261 39 end end NN cord-004862-yv76yvy5 261 40 , , , cord-004862-yv76yvy5 261 41 resulting result VBG cord-004862-yv76yvy5 261 42 in in IN cord-004862-yv76yvy5 261 43 a a DT cord-004862-yv76yvy5 261 44 higher high JJR cord-004862-yv76yvy5 261 45 frequency frequency NN cord-004862-yv76yvy5 261 46 in in IN cord-004862-yv76yvy5 261 47 the the DT cord-004862-yv76yvy5 261 48 genome genome NN cord-004862-yv76yvy5 261 49 of of IN cord-004862-yv76yvy5 261 50 the the DT cord-004862-yv76yvy5 261 51 3 3 CD cord-004862-yv76yvy5 261 52 ' ' NN cord-004862-yv76yvy5 261 53 end end NN cord-004862-yv76yvy5 261 54 of of IN cord-004862-yv76yvy5 261 55 L1 L1 NNP cord-004862-yv76yvy5 261 56 ( ( -LRB- cord-004862-yv76yvy5 261 57 about about RB cord-004862-yv76yvy5 261 58 50,000 50,000 CD cord-004862-yv76yvy5 261 59 copies copy NNS cord-004862-yv76yvy5 261 60 ) ) -RRB- cord-004862-yv76yvy5 261 61 than than IN cord-004862-yv76yvy5 261 62 the the DT cord-004862-yv76yvy5 261 63 5 5 CD cord-004862-yv76yvy5 261 64 ' ' NN cord-004862-yv76yvy5 261 65 end end NN cord-004862-yv76yvy5 261 66 ( ( -LRB- cord-004862-yv76yvy5 261 67 about about RB cord-004862-yv76yvy5 261 68 10,000 10,000 CD cord-004862-yv76yvy5 261 69 copies copy NNS cord-004862-yv76yvy5 261 70 ) ) -RRB- cord-004862-yv76yvy5 261 71 . . . cord-004862-yv76yvy5 262 1 This this DT cord-004862-yv76yvy5 262 2 similarity similarity NN cord-004862-yv76yvy5 262 3 in in IN cord-004862-yv76yvy5 262 4 copy copy NN cord-004862-yv76yvy5 262 5 number number NN cord-004862-yv76yvy5 262 6 suggests suggest VBZ cord-004862-yv76yvy5 262 7 that that IN cord-004862-yv76yvy5 262 8 the the DT cord-004862-yv76yvy5 262 9 time time NN cord-004862-yv76yvy5 262 10 of of IN cord-004862-yv76yvy5 262 11 onset onset NN cord-004862-yv76yvy5 262 12 and and CC cord-004862-yv76yvy5 262 13 the the DT cord-004862-yv76yvy5 262 14 rate rate NN cord-004862-yv76yvy5 262 15 of of IN cord-004862-yv76yvy5 262 16 propagation propagation NN cord-004862-yv76yvy5 262 17 of of IN cord-004862-yv76yvy5 262 18 L1 L1 NNP cord-004862-yv76yvy5 262 19 repeats repeat VBZ cord-004862-yv76yvy5 262 20 is be VBZ cord-004862-yv76yvy5 262 21 similar similar JJ cord-004862-yv76yvy5 262 22 in in IN cord-004862-yv76yvy5 262 23 the the DT cord-004862-yv76yvy5 262 24 different different JJ cord-004862-yv76yvy5 262 25 species specie NNS cord-004862-yv76yvy5 262 26 . . . cord-004862-yv76yvy5 263 1 The the DT cord-004862-yv76yvy5 263 2 rabbit rabbit NN cord-004862-yv76yvy5 263 3 , , , cord-004862-yv76yvy5 263 4 mouse mouse NN cord-004862-yv76yvy5 263 5 , , , cord-004862-yv76yvy5 263 6 and and CC cord-004862-yv76yvy5 263 7 monkey monkey NN cord-004862-yv76yvy5 263 8 L1 L1 NNP cord-004862-yv76yvy5 263 9 repeats repeat VBZ cord-004862-yv76yvy5 263 10 also also RB cord-004862-yv76yvy5 263 11 show show VBP cord-004862-yv76yvy5 263 12 a a DT cord-004862-yv76yvy5 263 13 similar similar JJ cord-004862-yv76yvy5 263 14 pattern pattern NN cord-004862-yv76yvy5 263 15 for for IN cord-004862-yv76yvy5 263 16 the the DT cord-004862-yv76yvy5 263 17 increase increase NN cord-004862-yv76yvy5 263 18 in in IN cord-004862-yv76yvy5 263 19 copy copy NN cord-004862-yv76yvy5 263 20 number number NN cord-004862-yv76yvy5 263 21 in in IN cord-004862-yv76yvy5 263 22 which which WDT cord-004862-yv76yvy5 263 23 the the DT cord-004862-yv76yvy5 263 24 5 5 CD cord-004862-yv76yvy5 263 25 ' ' POS cord-004862-yv76yvy5 263 26 regions region NNS cord-004862-yv76yvy5 263 27 increase increase VB cord-004862-yv76yvy5 263 28 gradually gradually RB cord-004862-yv76yvy5 263 29 in in IN cord-004862-yv76yvy5 263 30 copy copy NN cord-004862-yv76yvy5 263 31 number number NN cord-004862-yv76yvy5 263 32 before before IN cord-004862-yv76yvy5 263 33 a a DT cord-004862-yv76yvy5 263 34 large large JJ cord-004862-yv76yvy5 263 35 increase increase NN cord-004862-yv76yvy5 263 36 in in IN cord-004862-yv76yvy5 263 37 copy copy NN cord-004862-yv76yvy5 263 38 number number NN cord-004862-yv76yvy5 263 39 at at IN cord-004862-yv76yvy5 263 40 the the DT cord-004862-yv76yvy5 263 41 very very JJ cord-004862-yv76yvy5 263 42 3 3 CD cord-004862-yv76yvy5 263 43 ' ' '' cord-004862-yv76yvy5 263 44 end end NN cord-004862-yv76yvy5 263 45 . . . cord-004862-yv76yvy5 264 1 This this DT cord-004862-yv76yvy5 264 2 very very RB cord-004862-yv76yvy5 264 3 large large JJ cord-004862-yv76yvy5 264 4 increase increase NN cord-004862-yv76yvy5 264 5 in in IN cord-004862-yv76yvy5 264 6 copy copy NN cord-004862-yv76yvy5 264 7 number number NN cord-004862-yv76yvy5 264 8 in in IN cord-004862-yv76yvy5 264 9 the the DT cord-004862-yv76yvy5 264 10 Y Y NNP cord-004862-yv76yvy5 264 11 region region NN cord-004862-yv76yvy5 264 12 could could MD cord-004862-yv76yvy5 264 13 indicate indicate VB cord-004862-yv76yvy5 264 14 a a DT cord-004862-yv76yvy5 264 15 strong strong JJ cord-004862-yv76yvy5 264 16 stop stop NN cord-004862-yv76yvy5 264 17 for for IN cord-004862-yv76yvy5 264 18 reverse reverse JJ cord-004862-yv76yvy5 264 19 transcriptase transcriptase NN cord-004862-yv76yvy5 264 20 during during IN cord-004862-yv76yvy5 264 21 the the DT cord-004862-yv76yvy5 264 22 conversion conversion NN cord-004862-yv76yvy5 264 23 of of IN cord-004862-yv76yvy5 264 24 the the DT cord-004862-yv76yvy5 264 25 L1 L1 NNP cord-004862-yv76yvy5 264 26 transcript transcript NN cord-004862-yv76yvy5 264 27 to to IN cord-004862-yv76yvy5 264 28 a a DT cord-004862-yv76yvy5 264 29 DNA dna NN cord-004862-yv76yvy5 264 30 copy copy NN cord-004862-yv76yvy5 264 31 . . . cord-004862-yv76yvy5 265 1 Given give VBN cord-004862-yv76yvy5 265 2 this this DT cord-004862-yv76yvy5 265 3 frequency frequency NN cord-004862-yv76yvy5 265 4 of of IN cord-004862-yv76yvy5 265 5 polar polar JJ cord-004862-yv76yvy5 265 6 truncations truncation NNS cord-004862-yv76yvy5 265 7 of of IN cord-004862-yv76yvy5 265 8 L1 L1 NNP cord-004862-yv76yvy5 265 9 in in IN cord-004862-yv76yvy5 265 10 rabbits rabbit NNS cord-004862-yv76yvy5 265 11 , , , cord-004862-yv76yvy5 265 12 humans human NNS cord-004862-yv76yvy5 265 13 , , , cord-004862-yv76yvy5 265 14 and and CC cord-004862-yv76yvy5 265 15 mice mouse NNS cord-004862-yv76yvy5 265 16 , , , cord-004862-yv76yvy5 265 17 it -PRON- PRP cord-004862-yv76yvy5 265 18 is be VBZ cord-004862-yv76yvy5 265 19 striking strike VBG cord-004862-yv76yvy5 265 20 that that IN cord-004862-yv76yvy5 265 21 most most JJS cord-004862-yv76yvy5 265 22 of of IN cord-004862-yv76yvy5 265 23 the the DT cord-004862-yv76yvy5 265 24 L1 L1 NNP cord-004862-yv76yvy5 265 25 repeats repeat VBZ cord-004862-yv76yvy5 265 26 in in IN cord-004862-yv76yvy5 265 27 rats rat NNS cord-004862-yv76yvy5 265 28 are be VBP cord-004862-yv76yvy5 265 29 full full JJ cord-004862-yv76yvy5 265 30 length length NN cord-004862-yv76yvy5 265 31 ( ( -LRB- cord-004862-yv76yvy5 265 32 D D NNP cord-004862-yv76yvy5 265 33 ' ' '' cord-004862-yv76yvy5 265 34 Am Am NNP cord-004862-yv76yvy5 265 35 - - HYPH cord-004862-yv76yvy5 265 36 brosio brosio NNP cord-004862-yv76yvy5 265 37 et et FW cord-004862-yv76yvy5 265 38 al al NNP cord-004862-yv76yvy5 265 39 . . NNP cord-004862-yv76yvy5 265 40 1986 1986 CD cord-004862-yv76yvy5 265 41 ) ) -RRB- cord-004862-yv76yvy5 265 42 . . . cord-004862-yv76yvy5 266 1 Some some DT cord-004862-yv76yvy5 266 2 aspect aspect NN cord-004862-yv76yvy5 266 3 of of IN cord-004862-yv76yvy5 266 4 the the DT cord-004862-yv76yvy5 266 5 mechanism mechanism NN cord-004862-yv76yvy5 266 6 for for IN cord-004862-yv76yvy5 266 7 synthesis synthesis NN cord-004862-yv76yvy5 266 8 and and CC cord-004862-yv76yvy5 266 9 propagation propagation NN cord-004862-yv76yvy5 266 10 of of IN cord-004862-yv76yvy5 266 11 the the DT cord-004862-yv76yvy5 266 12 Lls Lls NNP cord-004862-yv76yvy5 266 13 is be VBZ cord-004862-yv76yvy5 266 14 apparently apparently RB cord-004862-yv76yvy5 266 15 different different JJ cord-004862-yv76yvy5 266 16 in in IN cord-004862-yv76yvy5 266 17 rats rat NNS cord-004862-yv76yvy5 266 18 , , , cord-004862-yv76yvy5 266 19 e.g. e.g. RB cord-004862-yv76yvy5 266 20 , , , cord-004862-yv76yvy5 266 21 to to TO cord-004862-yv76yvy5 266 22 allow allow VB cord-004862-yv76yvy5 266 23 more more RBR cord-004862-yv76yvy5 266 24 full full JJ cord-004862-yv76yvy5 266 25 length length NN cord-004862-yv76yvy5 266 26 reverse reverse NN cord-004862-yv76yvy5 266 27 transcripts transcript NNS cord-004862-yv76yvy5 266 28 or or CC cord-004862-yv76yvy5 266 29 to to TO cord-004862-yv76yvy5 266 30 select select VB cord-004862-yv76yvy5 266 31 for for IN cord-004862-yv76yvy5 266 32 these these DT cord-004862-yv76yvy5 266 33 in in IN cord-004862-yv76yvy5 266 34 the the DT cord-004862-yv76yvy5 266 35 integration integration NN cord-004862-yv76yvy5 266 36 process process NN cord-004862-yv76yvy5 266 37 . . . cord-004862-yv76yvy5 267 1 Full full JJ cord-004862-yv76yvy5 267 2 length length NN cord-004862-yv76yvy5 267 3 L1 L1 NNP cord-004862-yv76yvy5 267 4 transcripts transcript NNS cord-004862-yv76yvy5 267 5 have have VBP cord-004862-yv76yvy5 267 6 been be VBN cord-004862-yv76yvy5 267 7 observed observe VBN cord-004862-yv76yvy5 267 8 in in IN cord-004862-yv76yvy5 267 9 teratocarcinoma teratocarcinoma NNP cord-004862-yv76yvy5 267 10 cells cell NNS cord-004862-yv76yvy5 267 11 ( ( -LRB- cord-004862-yv76yvy5 267 12 Skowronski Skowronski NNP cord-004862-yv76yvy5 267 13 and and CC cord-004862-yv76yvy5 267 14 Singer Singer NNP cord-004862-yv76yvy5 267 15 1985 1985 CD cord-004862-yv76yvy5 267 16 ) ) -RRB- cord-004862-yv76yvy5 267 17 . . . cord-004862-yv76yvy5 268 1 Given give VBN cord-004862-yv76yvy5 268 2 the the DT cord-004862-yv76yvy5 268 3 assignments assignment NNS cord-004862-yv76yvy5 268 4 of of IN cord-004862-yv76yvy5 268 5 start start NN cord-004862-yv76yvy5 268 6 and and CC cord-004862-yv76yvy5 268 7 stop stop VB cord-004862-yv76yvy5 268 8 codons codon NNS cord-004862-yv76yvy5 268 9 proposed propose VBN cord-004862-yv76yvy5 268 10 in in IN cord-004862-yv76yvy5 268 11 this this DT cord-004862-yv76yvy5 268 12 paper paper NN cord-004862-yv76yvy5 268 13 , , , cord-004862-yv76yvy5 268 14 then then RB cord-004862-yv76yvy5 268 15 transcripts transcript NNS cord-004862-yv76yvy5 268 16 of of IN cord-004862-yv76yvy5 268 17 the the DT cord-004862-yv76yvy5 268 18 L1 L1 NNP cord-004862-yv76yvy5 268 19 repeat repeat NN cord-004862-yv76yvy5 268 20 of of IN cord-004862-yv76yvy5 268 21 rabbits rabbit NNS cord-004862-yv76yvy5 268 22 and and CC cord-004862-yv76yvy5 268 23 humans human NNS cord-004862-yv76yvy5 268 24 have have VBP cord-004862-yv76yvy5 268 25 the the DT cord-004862-yv76yvy5 268 26 characteristics characteristic NNS cord-004862-yv76yvy5 268 27 of of IN cord-004862-yv76yvy5 268 28 a a DT cord-004862-yv76yvy5 268 29 dicistronic dicistronic JJ cord-004862-yv76yvy5 268 30 RNA RNA NNP cord-004862-yv76yvy5 268 31 . . . cord-004862-yv76yvy5 269 1 Polycistronic Polycistronic NNP cord-004862-yv76yvy5 269 2 mRNAs mRNAs NNPS cord-004862-yv76yvy5 269 3 are be VBP cord-004862-yv76yvy5 269 4 common common JJ cord-004862-yv76yvy5 269 5 in in IN cord-004862-yv76yvy5 269 6 bacteria bacteria NNS cord-004862-yv76yvy5 269 7 , , , cord-004862-yv76yvy5 269 8 and and CC cord-004862-yv76yvy5 269 9 a a DT cord-004862-yv76yvy5 269 10 polycistronic polycistronic JJ cord-004862-yv76yvy5 269 11 arrangement arrangement NN cord-004862-yv76yvy5 269 12 of of IN cord-004862-yv76yvy5 269 13 genes gene NNS cord-004862-yv76yvy5 269 14 is be VBZ cord-004862-yv76yvy5 269 15 found find VBN cord-004862-yv76yvy5 269 16 in in IN cord-004862-yv76yvy5 269 17 the the DT cord-004862-yv76yvy5 269 18 genomes genome NNS cord-004862-yv76yvy5 269 19 of of IN cord-004862-yv76yvy5 269 20 some some DT cord-004862-yv76yvy5 269 21 RNA RNA NNP cord-004862-yv76yvy5 269 22 viruses virus NNS cord-004862-yv76yvy5 269 23 that that WDT cord-004862-yv76yvy5 269 24 infect infect VBP cord-004862-yv76yvy5 269 25 animals animal NNS cord-004862-yv76yvy5 269 26 and and CC cord-004862-yv76yvy5 269 27 plants plant NNS cord-004862-yv76yvy5 269 28 , , , cord-004862-yv76yvy5 269 29 e.g. e.g. RB cord-004862-yv76yvy5 269 30 , , , cord-004862-yv76yvy5 269 31 togaviruses togaviruse NNS cord-004862-yv76yvy5 269 32 , , , cord-004862-yv76yvy5 269 33 coronaviruses coronaviruse NNS cord-004862-yv76yvy5 269 34 , , , cord-004862-yv76yvy5 269 35 and and CC cord-004862-yv76yvy5 269 36 tobacco tobacco NN cord-004862-yv76yvy5 269 37 mosaic mosaic NN cord-004862-yv76yvy5 269 38 virus virus NN cord-004862-yv76yvy5 269 39 . . . cord-004862-yv76yvy5 270 1 In in IN cord-004862-yv76yvy5 270 2 contrast contrast NN cord-004862-yv76yvy5 270 3 , , , cord-004862-yv76yvy5 270 4 most most JJS cord-004862-yv76yvy5 270 5 mRNAs mRNAs NNPS cord-004862-yv76yvy5 270 6 from from IN cord-004862-yv76yvy5 270 7 eukaryotic eukaryotic JJ cord-004862-yv76yvy5 270 8 cellular cellular JJ cord-004862-yv76yvy5 270 9 genes gene NNS cord-004862-yv76yvy5 270 10 are be VBP cord-004862-yv76yvy5 270 11 monocistronic monocistronic JJ cord-004862-yv76yvy5 270 12 . . . cord-004862-yv76yvy5 271 1 Regardless regardless RB cord-004862-yv76yvy5 271 2 of of IN cord-004862-yv76yvy5 271 3 whether whether IN cord-004862-yv76yvy5 271 4 the the DT cord-004862-yv76yvy5 271 5 ORFs orf NNS cord-004862-yv76yvy5 271 6 are be VBP cord-004862-yv76yvy5 271 7 overlapping overlap VBG cord-004862-yv76yvy5 271 8 , , , cord-004862-yv76yvy5 271 9 as as IN cord-004862-yv76yvy5 271 10 in in IN cord-004862-yv76yvy5 271 11 L1Md L1Md NNP cord-004862-yv76yvy5 271 12 , , , cord-004862-yv76yvy5 271 13 or or CC cord-004862-yv76yvy5 271 14 are be VBP cord-004862-yv76yvy5 271 15 part part NN cord-004862-yv76yvy5 271 16 of of IN cord-004862-yv76yvy5 271 17 a a DT cord-004862-yv76yvy5 271 18 dicistronic dicistronic JJ cord-004862-yv76yvy5 271 19 RNA RNA NNP cord-004862-yv76yvy5 271 20 , , , cord-004862-yv76yvy5 271 21 as as IN cord-004862-yv76yvy5 271 22 in in IN cord-004862-yv76yvy5 271 23 L1Oc L1Oc NNP cord-004862-yv76yvy5 271 24 and and CC cord-004862-yv76yvy5 271 25 L1Hs L1Hs NNP cord-004862-yv76yvy5 271 26 , , , cord-004862-yv76yvy5 271 27 the the DT cord-004862-yv76yvy5 271 28 structure structure NN cord-004862-yv76yvy5 271 29 of of IN cord-004862-yv76yvy5 271 30 the the DT cord-004862-yv76yvy5 271 31 L L NNP cord-004862-yv76yvy5 271 32 1 1 CD cord-004862-yv76yvy5 271 33 repeats repeat VBZ cord-004862-yv76yvy5 271 34 resembles resemble VBZ cord-004862-yv76yvy5 271 35 DNA dna NN cord-004862-yv76yvy5 271 36 copies copy NNS cord-004862-yv76yvy5 271 37 of of IN cord-004862-yv76yvy5 271 38 viral viral JJ cord-004862-yv76yvy5 271 39 genomes genome NNS cord-004862-yv76yvy5 271 40 more more JJR cord-004862-yv76yvy5 271 41 than than IN cord-004862-yv76yvy5 271 42 conventional conventional JJ cord-004862-yv76yvy5 271 43 cellular cellular JJ cord-004862-yv76yvy5 271 44 transcription transcription NN cord-004862-yv76yvy5 271 45 units unit NNS cord-004862-yv76yvy5 271 46 . . . cord-004862-yv76yvy5 272 1 This this DT cord-004862-yv76yvy5 272 2 suggests suggest VBZ cord-004862-yv76yvy5 272 3 that that IN cord-004862-yv76yvy5 272 4 the the DT cord-004862-yv76yvy5 272 5 ancestor ancestor NN cord-004862-yv76yvy5 272 6 to to IN cord-004862-yv76yvy5 272 7 L1 L1 NNP cord-004862-yv76yvy5 272 8 repeats repeat VBZ cord-004862-yv76yvy5 272 9 in in IN cord-004862-yv76yvy5 272 10 fact fact NN cord-004862-yv76yvy5 272 11 may may MD cord-004862-yv76yvy5 272 12 be be VB cord-004862-yv76yvy5 272 13 some some DT cord-004862-yv76yvy5 272 14 type type NN cord-004862-yv76yvy5 272 15 of of IN cord-004862-yv76yvy5 272 16 animal animal NN cord-004862-yv76yvy5 272 17 virus virus NN cord-004862-yv76yvy5 272 18 rather rather RB cord-004862-yv76yvy5 272 19 than than IN cord-004862-yv76yvy5 272 20 a a DT cord-004862-yv76yvy5 272 21 normal normal JJ cord-004862-yv76yvy5 272 22 cellular cellular JJ cord-004862-yv76yvy5 272 23 gene gene NN cord-004862-yv76yvy5 272 24 , , , cord-004862-yv76yvy5 272 25 as as IN cord-004862-yv76yvy5 272 26 is be VBZ cord-004862-yv76yvy5 272 27 often often RB cord-004862-yv76yvy5 272 28 proposed propose VBN cord-004862-yv76yvy5 272 29 ( ( -LRB- cord-004862-yv76yvy5 272 30 reviewed review VBN cord-004862-yv76yvy5 272 31 in in IN cord-004862-yv76yvy5 272 32 Weiner Weiner NNP cord-004862-yv76yvy5 272 33 et et NNP cord-004862-yv76yvy5 272 34 al al NNP cord-004862-yv76yvy5 272 35 . . NNP cord-004862-yv76yvy5 272 36 1986 1986 CD cord-004862-yv76yvy5 272 37 ) ) -RRB- cord-004862-yv76yvy5 272 38 . . . cord-004862-yv76yvy5 273 1 A a DT cord-004862-yv76yvy5 273 2 viral viral JJ cord-004862-yv76yvy5 273 3 ancestor ancestor NN cord-004862-yv76yvy5 273 4 with with IN cord-004862-yv76yvy5 273 5 a a DT cord-004862-yv76yvy5 273 6 wide wide JJ cord-004862-yv76yvy5 273 7 host host NN cord-004862-yv76yvy5 273 8 range range NN cord-004862-yv76yvy5 273 9 would would MD cord-004862-yv76yvy5 273 10 provide provide VB cord-004862-yv76yvy5 273 11 an an DT cord-004862-yv76yvy5 273 12 explanation explanation NN cord-004862-yv76yvy5 273 13 for for IN cord-004862-yv76yvy5 273 14 the the DT cord-004862-yv76yvy5 273 15 independent independent JJ cord-004862-yv76yvy5 273 16 , , , cord-004862-yv76yvy5 273 17 and and CC cord-004862-yv76yvy5 273 18 perhaps perhaps RB cord-004862-yv76yvy5 273 19 simultaneous simultaneous JJ cord-004862-yv76yvy5 273 20 , , , cord-004862-yv76yvy5 273 21 entry entry NN cord-004862-yv76yvy5 273 22 of of IN cord-004862-yv76yvy5 273 23 the the DT cord-004862-yv76yvy5 273 24 L1 L1 NNP cord-004862-yv76yvy5 273 25 element element NN cord-004862-yv76yvy5 273 26 into into IN cord-004862-yv76yvy5 273 27 different different JJ cord-004862-yv76yvy5 273 28 mammalian mammalian JJ cord-004862-yv76yvy5 273 29 genomes genome NNS cord-004862-yv76yvy5 273 30 . . . cord-004862-yv76yvy5 274 1 The the DT cord-004862-yv76yvy5 274 2 ORFs orf NNS cord-004862-yv76yvy5 274 3 in in IN cord-004862-yv76yvy5 274 4 the the DT cord-004862-yv76yvy5 274 5 L1 L1 NNP cord-004862-yv76yvy5 274 6 repeal repeal NN cord-004862-yv76yvy5 274 7 appear appear VBP cord-004862-yv76yvy5 274 8 to to TO cord-004862-yv76yvy5 274 9 encode encode VB cord-004862-yv76yvy5 274 10 hybrids hybrid NNS cord-004862-yv76yvy5 274 11 of of IN cord-004862-yv76yvy5 274 12 different different JJ cord-004862-yv76yvy5 274 13 types type NNS cord-004862-yv76yvy5 274 14 of of IN cord-004862-yv76yvy5 274 15 proteins protein NNS cord-004862-yv76yvy5 274 16 ( ( -LRB- cord-004862-yv76yvy5 274 17 Fig Fig NNP cord-004862-yv76yvy5 274 18 . . . cord-004862-yv76yvy5 274 19 11 11 CD cord-004862-yv76yvy5 274 20 ) ) -RRB- cord-004862-yv76yvy5 274 21 . . . cord-004862-yv76yvy5 275 1 OR.F-1 OR.F-1 NNP cord-004862-yv76yvy5 275 2 can can MD cord-004862-yv76yvy5 275 3 be be VB cord-004862-yv76yvy5 275 4 divided divide VBN cord-004862-yv76yvy5 275 5 into into IN cord-004862-yv76yvy5 275 6 two two CD cord-004862-yv76yvy5 275 7 parts part NNS cord-004862-yv76yvy5 275 8 , , , cord-004862-yv76yvy5 275 9 the the DT cord-004862-yv76yvy5 275 10 N n CD cord-004862-yv76yvy5 275 11 - - HYPH cord-004862-yv76yvy5 275 12 terminal terminal NN cord-004862-yv76yvy5 275 13 por por NN cord-004862-yv76yvy5 275 14 - - HYPH cord-004862-yv76yvy5 275 15 tion tion NN cord-004862-yv76yvy5 275 16 that that WDT cord-004862-yv76yvy5 275 17 is be VBZ cord-004862-yv76yvy5 275 18 not not RB cord-004862-yv76yvy5 275 19 well well RB cord-004862-yv76yvy5 275 20 conserved conserve VBN cord-004862-yv76yvy5 275 21 between between IN cord-004862-yv76yvy5 275 22 species specie NNS cord-004862-yv76yvy5 275 23 and and CC cord-004862-yv76yvy5 275 24 the the DT cord-004862-yv76yvy5 275 25 C C NNP cord-004862-yv76yvy5 275 26 - - HYPH cord-004862-yv76yvy5 275 27 terminal terminal NN cord-004862-yv76yvy5 275 28 portion portion NN cord-004862-yv76yvy5 275 29 that that WDT cord-004862-yv76yvy5 275 30 is be VBZ cord-004862-yv76yvy5 275 31 well well RB cord-004862-yv76yvy5 275 32 conserved conserved JJ cord-004862-yv76yvy5 275 33 . . . cord-004862-yv76yvy5 276 1 In in IN cord-004862-yv76yvy5 276 2 the the DT cord-004862-yv76yvy5 276 3 rabbit rabbit NN cord-004862-yv76yvy5 276 4 L l NN cord-004862-yv76yvy5 276 5 1 1 CD cord-004862-yv76yvy5 276 6 repeat repeat NN cord-004862-yv76yvy5 276 7 , , , cord-004862-yv76yvy5 276 8 a a DT cord-004862-yv76yvy5 276 9 sequence sequence NN cord-004862-yv76yvy5 276 10 similar similar JJ cord-004862-yv76yvy5 276 11 to to IN cord-004862-yv76yvy5 276 12 keratin keratin NN cord-004862-yv76yvy5 276 13 has have VBZ cord-004862-yv76yvy5 276 14 been be VBN cord-004862-yv76yvy5 276 15 fused fuse VBN cord-004862-yv76yvy5 276 16 to to IN cord-004862-yv76yvy5 276 17 the the DT cord-004862-yv76yvy5 276 18 conserved conserve VBN cord-004862-yv76yvy5 276 19 C c NN cord-004862-yv76yvy5 276 20 - - HYPH cord-004862-yv76yvy5 276 21 terminal terminal NN cord-004862-yv76yvy5 276 22 portion portion NN cord-004862-yv76yvy5 276 23 of of IN cord-004862-yv76yvy5 276 24 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 276 25 . . . cord-004862-yv76yvy5 277 1 Although although IN cord-004862-yv76yvy5 277 2 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 277 3 is be VBZ cord-004862-yv76yvy5 277 4 conserved conserve VBN cord-004862-yv76yvy5 277 5 in in IN cord-004862-yv76yvy5 277 6 L L NNP cord-004862-yv76yvy5 277 7 1 1 CD cord-004862-yv76yvy5 277 8 s s NN cord-004862-yv76yvy5 277 9 from from IN cord-004862-yv76yvy5 277 10 different different JJ cord-004862-yv76yvy5 277 11 orders order NNS cord-004862-yv76yvy5 277 12 of of IN cord-004862-yv76yvy5 277 13 mammals mammal NNS cord-004862-yv76yvy5 277 14 it -PRON- PRP cord-004862-yv76yvy5 277 15 also also RB cord-004862-yv76yvy5 277 16 seems seem VBZ cord-004862-yv76yvy5 277 17 to to TO cord-004862-yv76yvy5 277 18 be be VB cord-004862-yv76yvy5 277 19 a a DT cord-004862-yv76yvy5 277 20 hybrid hybrid NN cord-004862-yv76yvy5 277 21 of of IN cord-004862-yv76yvy5 277 22 sequences sequence NNS cord-004862-yv76yvy5 277 23 related relate VBN cord-004862-yv76yvy5 277 24 to to IN cord-004862-yv76yvy5 277 25 several several JJ cord-004862-yv76yvy5 277 26 proteins protein NNS cord-004862-yv76yvy5 277 27 ( ( -LRB- cord-004862-yv76yvy5 277 28 Fig fig NN cord-004862-yv76yvy5 277 29 . . . cord-004862-yv76yvy5 277 30 _SP cord-004862-yv76yvy5 278 1 I -PRON- PRP cord-004862-yv76yvy5 278 2 1 1 CD cord-004862-yv76yvy5 278 3 ) ) -RRB- cord-004862-yv76yvy5 278 4 . . . cord-004862-yv76yvy5 279 1 The the DT cord-004862-yv76yvy5 279 2 middle middle JJ cord-004862-yv76yvy5 279 3 portion portion NN cord-004862-yv76yvy5 279 4 of of IN cord-004862-yv76yvy5 279 5 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 279 6 is be VBZ cord-004862-yv76yvy5 279 7 related relate VBN cord-004862-yv76yvy5 279 8 to to TO cord-004862-yv76yvy5 279 9 reverse reverse VB cord-004862-yv76yvy5 279 10 transcriptase transcriptase NN cord-004862-yv76yvy5 279 11 ( ( -LRB- cord-004862-yv76yvy5 279 12 Hattori Hattori NNP cord-004862-yv76yvy5 279 13 et et NNP cord-004862-yv76yvy5 279 14 al al NNP cord-004862-yv76yvy5 279 15 . . NNP cord-004862-yv76yvy5 279 16 1986 1986 CD cord-004862-yv76yvy5 279 17 ; ; : cord-004862-yv76yvy5 279 18 Loeb Loeb NNP cord-004862-yv76yvy5 279 19 et et NNP cord-004862-yv76yvy5 279 20 al al NNP cord-004862-yv76yvy5 279 21 . . NNP cord-004862-yv76yvy5 279 22 1986 1986 CD cord-004862-yv76yvy5 279 23 ) ) -RRB- cord-004862-yv76yvy5 279 24 . . . cord-004862-yv76yvy5 280 1 Different different JJ cord-004862-yv76yvy5 280 2 parts part NNS cord-004862-yv76yvy5 280 3 of of IN cord-004862-yv76yvy5 280 4 the the DT cord-004862-yv76yvy5 280 5 C C NNP cord-004862-yv76yvy5 280 6 - - HYPH cord-004862-yv76yvy5 280 7 terminal terminal NN cord-004862-yv76yvy5 280 8 region region NN cord-004862-yv76yvy5 280 9 are be VBP cord-004862-yv76yvy5 280 10 related relate VBN cord-004862-yv76yvy5 280 11 to to IN cord-004862-yv76yvy5 280 12 transferrin transferrin NN cord-004862-yv76yvy5 280 13 ( ( -LRB- cord-004862-yv76yvy5 280 14 Hattori Hattori NNP cord-004862-yv76yvy5 280 15 et et NNP cord-004862-yv76yvy5 280 16 al al NNP cord-004862-yv76yvy5 280 17 . . NNP cord-004862-yv76yvy5 280 18 1986 1986 CD cord-004862-yv76yvy5 280 19 ) ) -RRB- cord-004862-yv76yvy5 280 20 and and CC cord-004862-yv76yvy5 280 21 to to IN cord-004862-yv76yvy5 280 22 nucleic nucleic JJ cord-004862-yv76yvy5 280 23 acid acid NN cord-004862-yv76yvy5 280 24 binding bind VBG cord-004862-yv76yvy5 280 25 proteins protein NNS cord-004862-yv76yvy5 280 26 with with IN cord-004862-yv76yvy5 280 27 the the DT cord-004862-yv76yvy5 280 28 cysteine cysteine NN cord-004862-yv76yvy5 280 29 structural structural JJ cord-004862-yv76yvy5 280 30 motif motif NN cord-004862-yv76yvy5 280 31 , , , cord-004862-yv76yvy5 280 32 such such JJ cord-004862-yv76yvy5 280 33 as as IN cord-004862-yv76yvy5 280 34 the the DT cord-004862-yv76yvy5 280 35 binding bind VBG cord-004862-yv76yvy5 280 36 proteins protein NNS cord-004862-yv76yvy5 280 37 derived derive VBN cord-004862-yv76yvy5 280 38 from from IN cord-004862-yv76yvy5 280 39 retroviral retroviral JJ cord-004862-yv76yvy5 280 40 gaggenes gaggene NNS cord-004862-yv76yvy5 280 41 ( ( -LRB- cord-004862-yv76yvy5 280 42 Fanning Fanning NNP cord-004862-yv76yvy5 280 43 and and CC cord-004862-yv76yvy5 280 44 Singer Singer NNP cord-004862-yv76yvy5 280 45 I987 i987 CD cord-004862-yv76yvy5 280 46 ) ) -RRB- cord-004862-yv76yvy5 280 47 . . . cord-004862-yv76yvy5 281 1 The the DT cord-004862-yv76yvy5 281 2 cysteine cysteine NN cord-004862-yv76yvy5 281 3 structural structural JJ cord-004862-yv76yvy5 281 4 motif motif NN cord-004862-yv76yvy5 281 5 is be VBZ cord-004862-yv76yvy5 281 6 related relate VBN cord-004862-yv76yvy5 281 7 to to IN cord-004862-yv76yvy5 281 8 the the DT cord-004862-yv76yvy5 281 9 zinc zinc NN cord-004862-yv76yvy5 281 10 fingers finger NNS cord-004862-yv76yvy5 281 11 characterized characterize VBN cord-004862-yv76yvy5 281 12 in in IN cord-004862-yv76yvy5 281 13 TFIIIA TFIIIA NNP cord-004862-yv76yvy5 281 14 and and CC cord-004862-yv76yvy5 281 15 other other JJ cord-004862-yv76yvy5 281 16 nucleic nucleic JJ cord-004862-yv76yvy5 281 17 acid acid NN cord-004862-yv76yvy5 281 18 binding bind VBG cord-004862-yv76yvy5 281 19 proteins protein NNS cord-004862-yv76yvy5 281 20 ( ( -LRB- cord-004862-yv76yvy5 281 21 Fanning Fanning NNP cord-004862-yv76yvy5 281 22 and and CC cord-004862-yv76yvy5 281 23 Singer Singer NNP cord-004862-yv76yvy5 281 24 1987 1987 CD cord-004862-yv76yvy5 281 25 ) ) -RRB- cord-004862-yv76yvy5 281 26 . . . cord-004862-yv76yvy5 282 1 This this DT cord-004862-yv76yvy5 282 2 pastiche pastiche NN cord-004862-yv76yvy5 282 3 of of IN cord-004862-yv76yvy5 282 4 similarities similarity NNS cord-004862-yv76yvy5 282 5 suggests suggest VBZ cord-004862-yv76yvy5 282 6 that that IN cord-004862-yv76yvy5 282 7 the the DT cord-004862-yv76yvy5 282 8 L1 L1 NNP cord-004862-yv76yvy5 282 9 element element NN cord-004862-yv76yvy5 282 10 is be VBZ cord-004862-yv76yvy5 282 11 a a DT cord-004862-yv76yvy5 282 12 fusion fusion NN cord-004862-yv76yvy5 282 13 of of IN cord-004862-yv76yvy5 282 14 several several JJ cord-004862-yv76yvy5 282 15 different different JJ cord-004862-yv76yvy5 282 16 sequences sequence NNS cord-004862-yv76yvy5 282 17 , , , cord-004862-yv76yvy5 282 18 Some some DT cord-004862-yv76yvy5 282 19 of of IN cord-004862-yv76yvy5 282 20 which which WDT cord-004862-yv76yvy5 282 21 are be VBP cord-004862-yv76yvy5 282 22 derived derive VBN cord-004862-yv76yvy5 282 23 from from IN cord-004862-yv76yvy5 282 24 cellular cellular JJ cord-004862-yv76yvy5 282 25 genes gene NNS cord-004862-yv76yvy5 282 26 , , , cord-004862-yv76yvy5 282 27 possibly possibly RB cord-004862-yv76yvy5 282 28 by by IN cord-004862-yv76yvy5 282 29 a a DT cord-004862-yv76yvy5 282 30 viral viral JJ cord-004862-yv76yvy5 282 31 vector vector NN cord-004862-yv76yvy5 282 32 . . . cord-004862-yv76yvy5 283 1 Another another DT cord-004862-yv76yvy5 283 2 fusion fusion NN cord-004862-yv76yvy5 283 3 event event NN cord-004862-yv76yvy5 283 4 may may MD cord-004862-yv76yvy5 283 5 account account VB cord-004862-yv76yvy5 283 6 for for IN cord-004862-yv76yvy5 283 7 the the DT cord-004862-yv76yvy5 283 8 variation variation NN cord-004862-yv76yvy5 283 9 in in IN cord-004862-yv76yvy5 283 10 sizes size NNS cord-004862-yv76yvy5 283 11 and and CC cord-004862-yv76yvy5 283 12 sequences sequence NNS cord-004862-yv76yvy5 283 13 of of IN cord-004862-yv76yvy5 283 14 the the DT cord-004862-yv76yvy5 283 15 3 3 CD cord-004862-yv76yvy5 283 16 ' ' POS cord-004862-yv76yvy5 283 17 untranslated untranslated JJ cord-004862-yv76yvy5 283 18 regions region NNS cord-004862-yv76yvy5 283 19 of of IN cord-004862-yv76yvy5 283 20 L1 L1 NNP cord-004862-yv76yvy5 283 21 repeats repeat VBZ cord-004862-yv76yvy5 283 22 in in IN cord-004862-yv76yvy5 283 23 different different JJ cord-004862-yv76yvy5 283 24 mammals mammal NNS cord-004862-yv76yvy5 283 25 . . . cord-004862-yv76yvy5 284 1 The the DT cord-004862-yv76yvy5 284 2 3 3 CD cord-004862-yv76yvy5 284 3 ' ' POS cord-004862-yv76yvy5 284 4 untranslated untranslated JJ cord-004862-yv76yvy5 284 5 regions region NNS cord-004862-yv76yvy5 284 6 of of IN cord-004862-yv76yvy5 284 7 orthologous orthologous JJ cord-004862-yv76yvy5 284 8 globin globin NN cord-004862-yv76yvy5 284 9 genes gene NNS cord-004862-yv76yvy5 284 10 in in IN cord-004862-yv76yvy5 284 11 mammals mammal NNS cord-004862-yv76yvy5 284 12 have have VBP cord-004862-yv76yvy5 284 13 retained retain VBN cord-004862-yv76yvy5 284 14 obvious obvious JJ cord-004862-yv76yvy5 284 15 sequence sequence NN cord-004862-yv76yvy5 284 16 similarities similarity NNS cord-004862-yv76yvy5 284 17 over over IN cord-004862-yv76yvy5 284 18 the the DT cord-004862-yv76yvy5 284 19 course course NN cord-004862-yv76yvy5 284 20 of of IN cord-004862-yv76yvy5 284 21 eutherian eutherian JJ cord-004862-yv76yvy5 284 22 evolution evolution NN cord-004862-yv76yvy5 284 23 ( ( -LRB- cord-004862-yv76yvy5 284 24 e.g. e.g. RB cord-004862-yv76yvy5 284 25 , , , cord-004862-yv76yvy5 284 26 Hardies Hardies NNP cord-004862-yv76yvy5 284 27 et et FW cord-004862-yv76yvy5 284 28 al al NNP cord-004862-yv76yvy5 284 29 . . . cord-004862-yv76yvy5 284 30 1984 1984 CD cord-004862-yv76yvy5 284 31 ; ; : cord-004862-yv76yvy5 284 32 Hardison Hardison NNP cord-004862-yv76yvy5 284 33 1984 1984 CD cord-004862-yv76yvy5 284 34 ) ) -RRB- cord-004862-yv76yvy5 284 35 , , , cord-004862-yv76yvy5 284 36 so so CC cord-004862-yv76yvy5 284 37 it -PRON- PRP cord-004862-yv76yvy5 284 38 is be VBZ cord-004862-yv76yvy5 284 39 puzzling puzzle VBG cord-004862-yv76yvy5 284 40 that that IN cord-004862-yv76yvy5 284 41 no no DT cord-004862-yv76yvy5 284 42 sequence sequence NN cord-004862-yv76yvy5 284 43 similarity similarity NN cord-004862-yv76yvy5 284 44 is be VBZ cord-004862-yv76yvy5 284 45 seen see VBN cord-004862-yv76yvy5 284 46 in in IN cord-004862-yv76yvy5 284 47 the the DT cord-004862-yv76yvy5 284 48 3 3 CD cord-004862-yv76yvy5 284 49 ' ' POS cord-004862-yv76yvy5 284 50 untranslated untranslated JJ cord-004862-yv76yvy5 284 51 region region NN cord-004862-yv76yvy5 284 52 of of IN cord-004862-yv76yvy5 284 53 L1 L1 NNP cord-004862-yv76yvy5 284 54 repeats repeat VBZ cord-004862-yv76yvy5 284 55 in in IN cord-004862-yv76yvy5 284 56 comparisons comparison NNS cord-004862-yv76yvy5 284 57 between between IN cord-004862-yv76yvy5 284 58 mammals mammal NNS cord-004862-yv76yvy5 284 59 ( ( -LRB- cord-004862-yv76yvy5 284 60 Fig fig NN cord-004862-yv76yvy5 284 61 . . . cord-004862-yv76yvy5 284 62 11 11 CD cord-004862-yv76yvy5 284 63 ) ) -RRB- cord-004862-yv76yvy5 284 64 . . . cord-004862-yv76yvy5 285 1 Perhaps perhaps RB cord-004862-yv76yvy5 285 2 the the DT cord-004862-yv76yvy5 285 3 conserved conserved JJ cord-004862-yv76yvy5 285 4 coding coding NN cord-004862-yv76yvy5 285 5 region region NN cord-004862-yv76yvy5 285 6 was be VBD cord-004862-yv76yvy5 285 7 fused fuse VBN cord-004862-yv76yvy5 285 8 tO to IN cord-004862-yv76yvy5 285 9 a a DT cord-004862-yv76yvy5 285 10 different different JJ cord-004862-yv76yvy5 285 11 3 3 CD cord-004862-yv76yvy5 285 12 ' ' POS cord-004862-yv76yvy5 285 13 untranslated untranslated JJ cord-004862-yv76yvy5 285 14 sequence sequence NN cord-004862-yv76yvy5 285 15 in in IN cord-004862-yv76yvy5 285 16 each each DT cord-004862-yv76yvy5 285 17 species specie NNS cord-004862-yv76yvy5 285 18 . . . cord-004862-yv76yvy5 286 1 It -PRON- PRP cord-004862-yv76yvy5 286 2 is be VBZ cord-004862-yv76yvy5 286 3 noteworthy noteworthy JJ cord-004862-yv76yvy5 286 4 that that IN cord-004862-yv76yvy5 286 5 the the DT cord-004862-yv76yvy5 286 6 5 5 CD cord-004862-yv76yvy5 286 7 ' ' NN cord-004862-yv76yvy5 286 8 end end NN cord-004862-yv76yvy5 286 9 of of IN cord-004862-yv76yvy5 286 10 L1Ocl l1ocl NN cord-004862-yv76yvy5 286 11 begins begin VBZ cord-004862-yv76yvy5 286 12 immediately immediately RB cord-004862-yv76yvy5 286 13 after after IN cord-004862-yv76yvy5 286 14 the the DT cord-004862-yv76yvy5 286 15 conserved conserve VBN cord-004862-yv76yvy5 286 16 termination termination NN cord-004862-yv76yvy5 286 17 codon codon NN cord-004862-yv76yvy5 286 18 that that WDT cord-004862-yv76yvy5 286 19 ends end VBZ cord-004862-yv76yvy5 286 20 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 286 21 , , , cord-004862-yv76yvy5 286 22 suggesting suggest VBG cord-004862-yv76yvy5 286 23 that that IN cord-004862-yv76yvy5 286 24 the the DT cord-004862-yv76yvy5 286 25 sequence sequence NN cord-004862-yv76yvy5 286 26 corresponding correspond VBG cord-004862-yv76yvy5 286 27 to to IN cord-004862-yv76yvy5 286 28 the the DT cord-004862-yv76yvy5 286 29 3 3 CD cord-004862-yv76yvy5 286 30 ' ' POS cord-004862-yv76yvy5 286 31 untranslated untranslated JJ cord-004862-yv76yvy5 286 32 region region NN cord-004862-yv76yvy5 286 33 of of IN cord-004862-yv76yvy5 286 34 L L NNP cord-004862-yv76yvy5 286 35 1Oc 1oc CD cord-004862-yv76yvy5 286 36 may may MD cord-004862-yv76yvy5 286 37 exist exist VB cord-004862-yv76yvy5 286 38 as as IN cord-004862-yv76yvy5 286 39 a a DT cord-004862-yv76yvy5 286 40 distinct distinct JJ cord-004862-yv76yvy5 286 41 repetitive repetitive JJ cord-004862-yv76yvy5 286 42 element element NN cord-004862-yv76yvy5 286 43 in in IN cord-004862-yv76yvy5 286 44 the the DT cord-004862-yv76yvy5 286 45 rabbit rabbit NN cord-004862-yv76yvy5 286 46 genome genome NN cord-004862-yv76yvy5 286 47 in in IN cord-004862-yv76yvy5 286 48 addition addition NN cord-004862-yv76yvy5 286 49 to to IN cord-004862-yv76yvy5 286 50 its -PRON- PRP$ cord-004862-yv76yvy5 286 51 presence presence NN cord-004862-yv76yvy5 286 52 in in IN cord-004862-yv76yvy5 286 53 the the DT cord-004862-yv76yvy5 286 54 L1 L1 NNP cord-004862-yv76yvy5 286 55 sequence sequence NN cord-004862-yv76yvy5 286 56 . . . cord-004862-yv76yvy5 287 1 If if IN cord-004862-yv76yvy5 287 2 so so RB cord-004862-yv76yvy5 287 3 , , , cord-004862-yv76yvy5 287 4 this this DT cord-004862-yv76yvy5 287 5 would would MD cord-004862-yv76yvy5 287 6 be be VB cord-004862-yv76yvy5 287 7 an an DT cord-004862-yv76yvy5 287 8 additional additional JJ cord-004862-yv76yvy5 287 9 factor factor NN cord-004862-yv76yvy5 287 10 in in IN cord-004862-yv76yvy5 287 11 explaining explain VBG cord-004862-yv76yvy5 287 12 the the DT cord-004862-yv76yvy5 287 13 large large JJ cord-004862-yv76yvy5 287 14 increase increase NN cord-004862-yv76yvy5 287 15 in in IN cord-004862-yv76yvy5 287 16 copy copy NN cord-004862-yv76yvy5 287 17 number number NN cord-004862-yv76yvy5 287 18 of of IN cord-004862-yv76yvy5 287 19 Ll Ll NNP cord-004862-yv76yvy5 287 20 repeats repeat VBZ cord-004862-yv76yvy5 287 21 in in IN cord-004862-yv76yvy5 287 22 this this DT cord-004862-yv76yvy5 287 23 region region NN cord-004862-yv76yvy5 287 24 . . . cord-004862-yv76yvy5 288 1 A a DT cord-004862-yv76yvy5 288 2 similar similar JJ cord-004862-yv76yvy5 288 3 situation situation NN cord-004862-yv76yvy5 288 4 has have VBZ cord-004862-yv76yvy5 288 5 been be VBN cord-004862-yv76yvy5 288 6 observed observe VBN cord-004862-yv76yvy5 288 7 in in IN cord-004862-yv76yvy5 288 8 Drosophila Drosophila NNP cord-004862-yv76yvy5 288 9 melanogaster melanogaster NN cord-004862-yv76yvy5 288 10 , , , cord-004862-yv76yvy5 288 11 in in IN cord-004862-yv76yvy5 288 12 which which WDT cord-004862-yv76yvy5 288 13 suffix suffix NN cord-004862-yv76yvy5 288 14 , , , cord-004862-yv76yvy5 288 15 an an DT cord-004862-yv76yvy5 288 16 element element NN cord-004862-yv76yvy5 288 17 repeated repeat VBD cord-004862-yv76yvy5 288 18 about about IN cord-004862-yv76yvy5 288 19 300 300 CD cord-004862-yv76yvy5 288 20 times time NNS cord-004862-yv76yvy5 288 21 in in IN cord-004862-yv76yvy5 288 22 the the DT cord-004862-yv76yvy5 288 23 genome genome NN cord-004862-yv76yvy5 288 24 , , , cord-004862-yv76yvy5 288 25 is be VBZ cord-004862-yv76yvy5 288 26 almost almost RB cord-004862-yv76yvy5 288 27 identical identical JJ cord-004862-yv76yvy5 288 28 to to IN cord-004862-yv76yvy5 288 29 the the DT cord-004862-yv76yvy5 288 30 sequence sequence NN cord-004862-yv76yvy5 288 31 of of IN cord-004862-yv76yvy5 288 32 the the DT cord-004862-yv76yvy5 288 33 3 3 CD cord-004862-yv76yvy5 288 34 ' ' POS cord-004862-yv76yvy5 288 35 untranslated untranslated JJ cord-004862-yv76yvy5 288 36 region region NN cord-004862-yv76yvy5 288 37 ( ( -LRB- cord-004862-yv76yvy5 288 38 but but CC cord-004862-yv76yvy5 288 39 not not RB cord-004862-yv76yvy5 288 40 the the DT cord-004862-yv76yvy5 288 41 coding code VBG cord-004862-yv76yvy5 288 42 region region NN cord-004862-yv76yvy5 288 43 ) ) -RRB- cord-004862-yv76yvy5 288 44 of of IN cord-004862-yv76yvy5 288 45 the the DT cord-004862-yv76yvy5 288 46 F F NNP cord-004862-yv76yvy5 288 47 element element NN cord-004862-yv76yvy5 288 48 that that WDT cord-004862-yv76yvy5 288 49 is be VBZ cord-004862-yv76yvy5 288 50 present present JJ cord-004862-yv76yvy5 288 51 about about IN cord-004862-yv76yvy5 288 52 70 70 CD cord-004862-yv76yvy5 288 53 times time NNS cord-004862-yv76yvy5 288 54 in in IN cord-004862-yv76yvy5 288 55 the the DT cord-004862-yv76yvy5 288 56 genome genome NN cord-004862-yv76yvy5 288 57 ( ( -LRB- cord-004862-yv76yvy5 288 58 DiNocera DiNocera NNP cord-004862-yv76yvy5 288 59 and and CC cord-004862-yv76yvy5 288 60 Casari Casari NNP cord-004862-yv76yvy5 288 61 1987 1987 CD cord-004862-yv76yvy5 288 62 ) ) -RRB- cord-004862-yv76yvy5 288 63 . . . cord-004862-yv76yvy5 289 1 The the DT cord-004862-yv76yvy5 289 2 mammalian mammalian JJ cord-004862-yv76yvy5 289 3 L1 L1 NNP cord-004862-yv76yvy5 289 4 repeats repeat VBZ cord-004862-yv76yvy5 289 5 show show VBP cord-004862-yv76yvy5 289 6 a a DT cord-004862-yv76yvy5 289 7 clear clear JJ cord-004862-yv76yvy5 289 8 similarity similarity NN cord-004862-yv76yvy5 289 9 to to IN cord-004862-yv76yvy5 289 10 the the DT cord-004862-yv76yvy5 289 11 ingi ingi NNP cord-004862-yv76yvy5 289 12 repeat repeat VB cord-004862-yv76yvy5 289 13 in in IN cord-004862-yv76yvy5 289 14 the the DT cord-004862-yv76yvy5 289 15 protozoan protozoan NN cord-004862-yv76yvy5 289 16 Trypanosoma Trypanosoma NNP cord-004862-yv76yvy5 289 17 brucei brucei NNP cord-004862-yv76yvy5 289 18 ( ( -LRB- cord-004862-yv76yvy5 289 19 Kimmel Kimmel NNP cord-004862-yv76yvy5 289 20 et et NNP cord-004862-yv76yvy5 289 21 al al NNP cord-004862-yv76yvy5 289 22 . . NNP cord-004862-yv76yvy5 289 23 1987 1987 CD cord-004862-yv76yvy5 289 24 ) ) -RRB- cord-004862-yv76yvy5 289 25 , , , cord-004862-yv76yvy5 289 26 the the DT cord-004862-yv76yvy5 289 27 I -PRON- PRP cord-004862-yv76yvy5 289 28 factor factor NN cord-004862-yv76yvy5 289 29 of of IN cord-004862-yv76yvy5 289 30 the the DT cord-004862-yv76yvy5 289 31 I I NNP cord-004862-yv76yvy5 289 32 - - HYPH cord-004862-yv76yvy5 289 33 R r NN cord-004862-yv76yvy5 289 34 system system NN cord-004862-yv76yvy5 289 35 of of IN cord-004862-yv76yvy5 289 36 hybrid hybrid JJ cord-004862-yv76yvy5 289 37 dysgenesis dysgenesis NN cord-004862-yv76yvy5 289 38 in in IN cord-004862-yv76yvy5 289 39 D. D. NNP cord-004862-yv76yvy5 289 40 melanogaster melanogaster NN cord-004862-yv76yvy5 289 41 ( ( -LRB- cord-004862-yv76yvy5 289 42 Fawcett Fawcett NNP cord-004862-yv76yvy5 289 43 et et FW cord-004862-yv76yvy5 289 44 al al NNP cord-004862-yv76yvy5 289 45 . . NNP cord-004862-yv76yvy5 289 46 1986 1986 CD cord-004862-yv76yvy5 289 47 ) ) -RRB- cord-004862-yv76yvy5 289 48 , , , cord-004862-yv76yvy5 289 49 F F NNP cord-004862-yv76yvy5 289 50 elements element NNS cord-004862-yv76yvy5 289 51 in in IN cord-004862-yv76yvy5 289 52 D. D. NNP cord-004862-yv76yvy5 289 53 melanogaster melanogaster NNP cord-004862-yv76yvy5 289 54 ( ( -LRB- cord-004862-yv76yvy5 289 55 DiNocera DiNocera NNP cord-004862-yv76yvy5 289 56 and and CC cord-004862-yv76yvy5 289 57 Casari Casari NNP cord-004862-yv76yvy5 289 58 1987 1987 CD cord-004862-yv76yvy5 289 59 ) ) -RRB- cord-004862-yv76yvy5 289 60 , , , cord-004862-yv76yvy5 289 61 and and CC cord-004862-yv76yvy5 289 62 the the DT cord-004862-yv76yvy5 289 63 R r NN cord-004862-yv76yvy5 289 64 1 1 CD cord-004862-yv76yvy5 289 65 Bm Bm NNP cord-004862-yv76yvy5 289 66 ( ( -LRB- cord-004862-yv76yvy5 289 67 Xiong Xiong NNP cord-004862-yv76yvy5 289 68 and and CC cord-004862-yv76yvy5 289 69 Eickbush Eickbush NNP cord-004862-yv76yvy5 289 70 1988 1988 CD cord-004862-yv76yvy5 289 71 ) ) -RRB- cord-004862-yv76yvy5 289 72 and and CC cord-004862-yv76yvy5 289 73 R2Bm R2Bm NFP cord-004862-yv76yvy5 289 74 ( ( -LRB- cord-004862-yv76yvy5 289 75 Burke Burke NNP cord-004862-yv76yvy5 289 76 et et NNP cord-004862-yv76yvy5 289 77 al al NNP cord-004862-yv76yvy5 289 78 . . NNP cord-004862-yv76yvy5 289 79 1987 1987 CD cord-004862-yv76yvy5 289 80 ) ) -RRB- cord-004862-yv76yvy5 290 1 insertion insertion NN cord-004862-yv76yvy5 290 2 sequences sequence NNS cord-004862-yv76yvy5 290 3 in in IN cord-004862-yv76yvy5 290 4 some some DT cord-004862-yv76yvy5 290 5 rRNA rRNA NNP cord-004862-yv76yvy5 290 6 genes gene NNS cord-004862-yv76yvy5 290 7 OfBombyx OfBombyx NNP cord-004862-yv76yvy5 290 8 mori mori NNP cord-004862-yv76yvy5 290 9 ( ( -LRB- cord-004862-yv76yvy5 290 10 Fig Fig NNP cord-004862-yv76yvy5 290 11 . . . cord-004862-yv76yvy5 290 12 11 11 CD cord-004862-yv76yvy5 290 13 ) ) -RRB- cord-004862-yv76yvy5 290 14 . . . cord-004862-yv76yvy5 291 1 The the DT cord-004862-yv76yvy5 291 2 similarity similarity NN cord-004862-yv76yvy5 291 3 has have VBZ cord-004862-yv76yvy5 291 4 been be VBN cord-004862-yv76yvy5 291 5 17 17 CD cord-004862-yv76yvy5 291 6 recognized recognize VBN cord-004862-yv76yvy5 291 7 only only RB cord-004862-yv76yvy5 291 8 in in IN cord-004862-yv76yvy5 291 9 the the DT cord-004862-yv76yvy5 291 10 region region NN cord-004862-yv76yvy5 291 11 proposed propose VBD cord-004862-yv76yvy5 291 12 to to TO cord-004862-yv76yvy5 291 13 encode encode VB cord-004862-yv76yvy5 291 14 reverse reverse JJ cord-004862-yv76yvy5 291 15 transcriptase transcriptase NN cord-004862-yv76yvy5 291 16 , , , cord-004862-yv76yvy5 291 17 and and CC cord-004862-yv76yvy5 291 18 these these DT cord-004862-yv76yvy5 291 19 sequences sequence NNS cord-004862-yv76yvy5 291 20 are be VBP cord-004862-yv76yvy5 291 21 more more RBR cord-004862-yv76yvy5 291 22 similar similar JJ cord-004862-yv76yvy5 291 23 among among IN cord-004862-yv76yvy5 291 24 themselves -PRON- PRP cord-004862-yv76yvy5 291 25 than than IN cord-004862-yv76yvy5 291 26 to to TO cord-004862-yv76yvy5 291 27 retroviral retroviral JJ cord-004862-yv76yvy5 291 28 reverse reverse NN cord-004862-yv76yvy5 291 29 transcriptases transcriptase NNS cord-004862-yv76yvy5 291 30 ( ( -LRB- cord-004862-yv76yvy5 291 31 DiNocera DiNocera NNP cord-004862-yv76yvy5 291 32 and and CC cord-004862-yv76yvy5 291 33 Casari Casari NNP cord-004862-yv76yvy5 291 34 1987 1987 CD cord-004862-yv76yvy5 291 35 ; ; : cord-004862-yv76yvy5 291 36 Xiong Xiong NNP cord-004862-yv76yvy5 291 37 and and CC cord-004862-yv76yvy5 291 38 Eickbush Eickbush NNP cord-004862-yv76yvy5 291 39 1988 1988 CD cord-004862-yv76yvy5 291 40 ) ) -RRB- cord-004862-yv76yvy5 291 41 . . . cord-004862-yv76yvy5 292 1 The the DT cord-004862-yv76yvy5 292 2 mammalian mammalian JJ cord-004862-yv76yvy5 292 3 L1 L1 NNP cord-004862-yv76yvy5 292 4 s s NNP cord-004862-yv76yvy5 292 5 and and CC cord-004862-yv76yvy5 292 6 these these DT cord-004862-yv76yvy5 292 7 protozoan protozoan NN cord-004862-yv76yvy5 292 8 and and CC cord-004862-yv76yvy5 292 9 insect insect NN cord-004862-yv76yvy5 292 10 repeats repeat VBZ cord-004862-yv76yvy5 292 11 share share VBP cord-004862-yv76yvy5 293 1 other other JJ cord-004862-yv76yvy5 293 2 structural structural JJ cord-004862-yv76yvy5 293 3 features feature NNS cord-004862-yv76yvy5 293 4 , , , cord-004862-yv76yvy5 293 5 such such JJ cord-004862-yv76yvy5 293 6 as as IN cord-004862-yv76yvy5 293 7 the the DT cord-004862-yv76yvy5 293 8 absence absence NN cord-004862-yv76yvy5 293 9 of of IN cord-004862-yv76yvy5 293 10 long long JJ cord-004862-yv76yvy5 293 11 terminal terminal NN cord-004862-yv76yvy5 293 12 repeats repeat VBZ cord-004862-yv76yvy5 293 13 , , , cord-004862-yv76yvy5 293 14 the the DT cord-004862-yv76yvy5 293 15 presence presence NN cord-004862-yv76yvy5 293 16 of of IN cord-004862-yv76yvy5 293 17 at at RB cord-004862-yv76yvy5 293 18 least least RBS cord-004862-yv76yvy5 293 19 two two CD cord-004862-yv76yvy5 293 20 ORFs ORFs NNP cord-004862-yv76yvy5 293 21 ( ( -LRB- cord-004862-yv76yvy5 293 22 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 293 23 containing contain VBG cord-004862-yv76yvy5 293 24 sequences sequence NNS cord-004862-yv76yvy5 293 25 similar similar JJ cord-004862-yv76yvy5 293 26 to to TO cord-004862-yv76yvy5 293 27 reverse reverse VB cord-004862-yv76yvy5 293 28 transcriptase transcriptase NN cord-004862-yv76yvy5 293 29 and and CC cord-004862-yv76yvy5 293 30 either either CC cord-004862-yv76yvy5 293 31 ORF-1 ORF-1 NNP cord-004862-yv76yvy5 293 32 or or CC cord-004862-yv76yvy5 293 33 ORF-2 ORF-2 NNP cord-004862-yv76yvy5 293 34 encoding encode VBG cord-004862-yv76yvy5 293 35 a a DT cord-004862-yv76yvy5 293 36 cysteine cysteine NN cord-004862-yv76yvy5 293 37 motif motif NN cord-004862-yv76yvy5 293 38 ) ) -RRB- cord-004862-yv76yvy5 293 39 , , , cord-004862-yv76yvy5 293 40 a a DT cord-004862-yv76yvy5 293 41 length length NN cord-004862-yv76yvy5 293 42 from from IN cord-004862-yv76yvy5 293 43 5 5 CD cord-004862-yv76yvy5 293 44 to to IN cord-004862-yv76yvy5 293 45 7.5 7.5 CD cord-004862-yv76yvy5 293 46 kb kb NNP cord-004862-yv76yvy5 293 47 , , , cord-004862-yv76yvy5 293 48 and and CC cord-004862-yv76yvy5 293 49 a a DT cord-004862-yv76yvy5 293 50 3 3 CD cord-004862-yv76yvy5 293 51 ' ' POS cord-004862-yv76yvy5 293 52 untranslated untranslated JJ cord-004862-yv76yvy5 293 53 region region NN cord-004862-yv76yvy5 293 54 with with IN cord-004862-yv76yvy5 293 55 a a DT cord-004862-yv76yvy5 293 56 sequence sequence NN cord-004862-yv76yvy5 293 57 similar similar JJ cord-004862-yv76yvy5 293 58 to to IN cord-004862-yv76yvy5 293 59 AATAAA AATAAA NNP cord-004862-yv76yvy5 293 60 close close RB cord-004862-yv76yvy5 293 61 to to IN cord-004862-yv76yvy5 293 62 the the DT cord-004862-yv76yvy5 293 63 3 3 CD cord-004862-yv76yvy5 293 64 ' ' '' cord-004862-yv76yvy5 293 65 end end NN cord-004862-yv76yvy5 293 66 . . . cord-004862-yv76yvy5 294 1 The the DT cord-004862-yv76yvy5 294 2 dicistronic dicistronic JJ cord-004862-yv76yvy5 294 3 structure structure NN cord-004862-yv76yvy5 294 4 proposed propose VBD cord-004862-yv76yvy5 294 5 for for IN cord-004862-yv76yvy5 294 6 L1Oc L1Oc NNP cord-004862-yv76yvy5 294 7 and and CC cord-004862-yv76yvy5 294 8 LIHs lih NNS cord-004862-yv76yvy5 294 9 may may MD cord-004862-yv76yvy5 294 10 also also RB cord-004862-yv76yvy5 294 11 be be VB cord-004862-yv76yvy5 294 12 present present JJ cord-004862-yv76yvy5 294 13 in in IN cord-004862-yv76yvy5 294 14 the the DT cord-004862-yv76yvy5 294 15 I -PRON- PRP cord-004862-yv76yvy5 294 16 factor factor NN cord-004862-yv76yvy5 294 17 , , , cord-004862-yv76yvy5 294 18 the the DT cord-004862-yv76yvy5 294 19 F F NNP cord-004862-yv76yvy5 294 20 element element NN cord-004862-yv76yvy5 294 21 , , , cord-004862-yv76yvy5 294 22 and and CC cord-004862-yv76yvy5 294 23 the the DT cord-004862-yv76yvy5 294 24 R r NN cord-004862-yv76yvy5 294 25 IBm ibm NN cord-004862-yv76yvy5 294 26 repeat repeat NN cord-004862-yv76yvy5 294 27 ( ( -LRB- cord-004862-yv76yvy5 295 1 Fawcett Fawcett NNP cord-004862-yv76yvy5 295 2 et et NNP cord-004862-yv76yvy5 295 3 al al NNP cord-004862-yv76yvy5 295 4 . . NNP cord-004862-yv76yvy5 295 5 1986 1986 CD cord-004862-yv76yvy5 295 6 ; ; : cord-004862-yv76yvy5 295 7 DiNocera DiNocera NNP cord-004862-yv76yvy5 295 8 and and CC cord-004862-yv76yvy5 295 9 Casari Casari NNP cord-004862-yv76yvy5 295 10 1987 1987 CD cord-004862-yv76yvy5 295 11 ; ; : cord-004862-yv76yvy5 295 12 Xiong Xiong NNP cord-004862-yv76yvy5 295 13 and and CC cord-004862-yv76yvy5 295 14 Eickbush Eickbush NNP cord-004862-yv76yvy5 295 15 1988 1988 CD cord-004862-yv76yvy5 295 16 ) ) -RRB- cord-004862-yv76yvy5 295 17 . . . cord-004862-yv76yvy5 296 1 Each each DT cord-004862-yv76yvy5 296 2 type type NN cord-004862-yv76yvy5 296 3 of of IN cord-004862-yv76yvy5 296 4 repeated repeat VBN cord-004862-yv76yvy5 296 5 element element NN cord-004862-yv76yvy5 296 6 also also RB cord-004862-yv76yvy5 296 7 has have VBZ cord-004862-yv76yvy5 296 8 some some DT cord-004862-yv76yvy5 296 9 distinctive distinctive JJ cord-004862-yv76yvy5 296 10 features feature NNS cord-004862-yv76yvy5 296 11 , , , cord-004862-yv76yvy5 296 12 e.g. e.g. RB cord-004862-yv76yvy5 296 13 , , , cord-004862-yv76yvy5 296 14 the the DT cord-004862-yv76yvy5 296 15 specific specific JJ cord-004862-yv76yvy5 296 16 insertion insertion NN cord-004862-yv76yvy5 296 17 sites site NNS cord-004862-yv76yvy5 296 18 for for IN cord-004862-yv76yvy5 296 19 R1Bm R1Bm NNS cord-004862-yv76yvy5 296 20 and and CC cord-004862-yv76yvy5 296 21 R2Bm R2Bm NNPS cord-004862-yv76yvy5 296 22 in in IN cord-004862-yv76yvy5 296 23 the the DT cord-004862-yv76yvy5 296 24 rRNA rRNA NNP cord-004862-yv76yvy5 296 25 genes gene NNS cord-004862-yv76yvy5 296 26 and and CC cord-004862-yv76yvy5 296 27 the the DT cord-004862-yv76yvy5 296 28 absence absence NN cord-004862-yv76yvy5 296 29 of of IN cord-004862-yv76yvy5 296 30 A a DT cord-004862-yv76yvy5 296 31 - - HYPH cord-004862-yv76yvy5 296 32 rich rich JJ cord-004862-yv76yvy5 296 33 tracts tract NNS cord-004862-yv76yvy5 296 34 at at IN cord-004862-yv76yvy5 296 35 the the DT cord-004862-yv76yvy5 296 36 3 3 NN cord-004862-yv76yvy5 296 37 ' ' '' cord-004862-yv76yvy5 296 38 ends end NNS cord-004862-yv76yvy5 296 39 of of IN cord-004862-yv76yvy5 296 40 some some DT cord-004862-yv76yvy5 296 41 of of IN cord-004862-yv76yvy5 296 42 the the DT cord-004862-yv76yvy5 296 43 insect insect NN cord-004862-yv76yvy5 296 44 repeats repeat VBZ cord-004862-yv76yvy5 296 45 . . . cord-004862-yv76yvy5 297 1 However however RB cord-004862-yv76yvy5 297 2 , , , cord-004862-yv76yvy5 297 3 at at IN cord-004862-yv76yvy5 297 4 least least JJS cord-004862-yv76yvy5 297 5 parts part NNS cord-004862-yv76yvy5 297 6 of of IN cord-004862-yv76yvy5 297 7 these these DT cord-004862-yv76yvy5 297 8 repeats repeat NNS cord-004862-yv76yvy5 297 9 in in IN cord-004862-yv76yvy5 297 10 mammals mammal NNS cord-004862-yv76yvy5 297 11 , , , cord-004862-yv76yvy5 297 12 insects insect NNS cord-004862-yv76yvy5 297 13 , , , cord-004862-yv76yvy5 297 14 and and CC cord-004862-yv76yvy5 297 15 a a DT cord-004862-yv76yvy5 297 16 parasitic parasitic JJ cord-004862-yv76yvy5 297 17 protozoan protozoan NN cord-004862-yv76yvy5 297 18 appear appear VBP cord-004862-yv76yvy5 297 19 to to TO cord-004862-yv76yvy5 297 20 be be VB cord-004862-yv76yvy5 297 21 evolutionarily evolutionarily RB cord-004862-yv76yvy5 297 22 related relate VBN cord-004862-yv76yvy5 297 23 . . . cord-004862-yv76yvy5 298 1 If if IN cord-004862-yv76yvy5 298 2 this this DT cord-004862-yv76yvy5 298 3 type type NN cord-004862-yv76yvy5 298 4 of of IN cord-004862-yv76yvy5 298 5 repeat repeat NN cord-004862-yv76yvy5 298 6 is be VBZ cord-004862-yv76yvy5 298 7 restricted restrict VBN cord-004862-yv76yvy5 298 8 to to IN cord-004862-yv76yvy5 298 9 these these DT cord-004862-yv76yvy5 298 10 groups group NNS cord-004862-yv76yvy5 298 11 of of IN cord-004862-yv76yvy5 298 12 organisms organism NNS cord-004862-yv76yvy5 298 13 , , , cord-004862-yv76yvy5 298 14 it -PRON- PRP cord-004862-yv76yvy5 298 15 may may MD cord-004862-yv76yvy5 298 16 indicate indicate VB cord-004862-yv76yvy5 298 17 that that IN cord-004862-yv76yvy5 298 18 the the DT cord-004862-yv76yvy5 298 19 genetic genetic JJ cord-004862-yv76yvy5 298 20 information information NN cord-004862-yv76yvy5 298 21 was be VBD cord-004862-yv76yvy5 298 22 transferred transfer VBN cord-004862-yv76yvy5 298 23 among among IN cord-004862-yv76yvy5 298 24 parasites parasite NNS cord-004862-yv76yvy5 298 25 , , , cord-004862-yv76yvy5 298 26 their -PRON- PRP$ cord-004862-yv76yvy5 298 27 mammalian mammalian JJ cord-004862-yv76yvy5 298 28 hosts host NNS cord-004862-yv76yvy5 298 29 , , , cord-004862-yv76yvy5 298 30 and and CC cord-004862-yv76yvy5 298 31 insect insect NN cord-004862-yv76yvy5 298 32 vectors vector NNS cord-004862-yv76yvy5 298 33 ( ( -LRB- cord-004862-yv76yvy5 298 34 K.immel K.immel NNP cord-004862-yv76yvy5 298 35 et et NNP cord-004862-yv76yvy5 298 36 al al NNP cord-004862-yv76yvy5 298 37 . . NNP cord-004862-yv76yvy5 298 38 1987 1987 CD cord-004862-yv76yvy5 298 39 ) ) -RRB- cord-004862-yv76yvy5 298 40 . . . cord-004862-yv76yvy5 299 1 A a DT cord-004862-yv76yvy5 299 2 viral viral JJ cord-004862-yv76yvy5 299 3 progenitor progenitor NN cord-004862-yv76yvy5 299 4 , , , cord-004862-yv76yvy5 299 5 suggested suggest VBN cord-004862-yv76yvy5 299 6 by by IN cord-004862-yv76yvy5 299 7 the the DT cord-004862-yv76yvy5 299 8 dicistronic dicistronic JJ cord-004862-yv76yvy5 299 9 arrangement arrangement NN cord-004862-yv76yvy5 299 10 shown show VBN cord-004862-yv76yvy5 299 11 in in IN cord-004862-yv76yvy5 299 12 this this DT cord-004862-yv76yvy5 299 13 paper paper NN cord-004862-yv76yvy5 299 14 , , , cord-004862-yv76yvy5 299 15 would would MD cord-004862-yv76yvy5 299 16 provide provide VB cord-004862-yv76yvy5 299 17 a a DT cord-004862-yv76yvy5 299 18 means means NN cord-004862-yv76yvy5 299 19 for for IN cord-004862-yv76yvy5 299 20 the the DT cord-004862-yv76yvy5 299 21 horizontal horizontal JJ cord-004862-yv76yvy5 299 22 transmission transmission NN cord-004862-yv76yvy5 299 23 of of IN cord-004862-yv76yvy5 299 24 the the DT cord-004862-yv76yvy5 299 25 L1 L1 NNP cord-004862-yv76yvy5 299 26 sequences sequence NNS cord-004862-yv76yvy5 299 27 . . . cord-004862-yv76yvy5 300 1 Retroviruses retrovirus NNS cord-004862-yv76yvy5 300 2 and and CC cord-004862-yv76yvy5 300 3 retrotransposons retrotransposon NNS cord-004862-yv76yvy5 300 4 : : : cord-004862-yv76yvy5 300 5 the the DT cord-004862-yv76yvy5 300 6 role role NN cord-004862-yv76yvy5 300 7 of of IN cord-004862-yv76yvy5 300 8 reverse reverse JJ cord-004862-yv76yvy5 300 9 transcription transcription NN cord-004862-yv76yvy5 300 10 in in IN cord-004862-yv76yvy5 300 11 shaping shape VBG cord-004862-yv76yvy5 300 12 the the DT cord-004862-yv76yvy5 300 13 eukaryotic eukaryotic JJ cord-004862-yv76yvy5 300 14 genome genome NN cord-004862-yv76yvy5 300 15 Screening Screening NNP cord-004862-yv76yvy5 300 16 Xgt Xgt NNP cord-004862-yv76yvy5 300 17 recombinant recombinant JJ cord-004862-yv76yvy5 300 18 clones clone NNS cord-004862-yv76yvy5 300 19 by by IN cord-004862-yv76yvy5 300 20 hybridization hybridization NN cord-004862-yv76yvy5 300 21 to to IN cord-004862-yv76yvy5 300 22 single single JJ cord-004862-yv76yvy5 300 23 plaques plaque NNS cord-004862-yv76yvy5 300 24 in in IN cord-004862-yv76yvy5 300 25 situ situ JJ cord-004862-yv76yvy5 300 26 Organization organization NN cord-004862-yv76yvy5 300 27 and and CC cord-004862-yv76yvy5 300 28 evolutionary evolutionary JJ cord-004862-yv76yvy5 300 29 progress progress NN cord-004862-yv76yvy5 300 30 of of IN cord-004862-yv76yvy5 300 31 a a DT cord-004862-yv76yvy5 300 32 dispersed disperse VBN cord-004862-yv76yvy5 300 33 repetitive repetitive JJ cord-004862-yv76yvy5 300 34 family family NN cord-004862-yv76yvy5 300 35 of of IN cord-004862-yv76yvy5 300 36 sequences sequence NNS cord-004862-yv76yvy5 300 37 in in IN cord-004862-yv76yvy5 300 38 widely widely RB cord-004862-yv76yvy5 300 39 separated separate VBN cord-004862-yv76yvy5 300 40 rodent rodent NN cord-004862-yv76yvy5 300 41 genomes genome NNS cord-004862-yv76yvy5 300 42 The the DT cord-004862-yv76yvy5 300 43 site site NN cord-004862-yv76yvy5 300 44 - - HYPH cord-004862-yv76yvy5 300 45 specific specific JJ cord-004862-yv76yvy5 300 46 ribosomal ribosomal JJ cord-004862-yv76yvy5 300 47 insertion insertion NN cord-004862-yv76yvy5 300 48 element element NN cord-004862-yv76yvy5 300 49 type type NN cord-004862-yv76yvy5 300 50 II II NNP cord-004862-yv76yvy5 300 51 ofBombyx ofBombyx NNP cord-004862-yv76yvy5 300 52 mori mori NN cord-004862-yv76yvy5 300 53 ( ( -LRB- cord-004862-yv76yvy5 300 54 R2Bm R2Bm NFP cord-004862-yv76yvy5 300 55 ) ) -RRB- cord-004862-yv76yvy5 300 56 contains contain VBZ cord-004862-yv76yvy5 300 57 the the DT cord-004862-yv76yvy5 300 58 coding code VBG cord-004862-yv76yvy5 300 59 sequence sequence NN cord-004862-yv76yvy5 300 60 for for IN cord-004862-yv76yvy5 300 61 a a DT cord-004862-yv76yvy5 300 62 reverse reverse JJ cord-004862-yv76yvy5 300 63 transcriptase transcriptase NN cord-004862-yv76yvy5 300 64 - - HYPH cord-004862-yv76yvy5 300 65 like like JJ cord-004862-yv76yvy5 300 66 enzyme enzyme NN cord-004862-yv76yvy5 300 67 Conservationthroughoutmammaliaand Conservationthroughoutmammaliaand NNP cord-004862-yv76yvy5 300 68 extensive extensive JJ cord-004862-yv76yvy5 300 69 protein protein NN cord-004862-yv76yvy5 300 70 encoding encoding NN cord-004862-yv76yvy5 300 71 capacity capacity NN cord-004862-yv76yvy5 300 72 of of IN cord-004862-yv76yvy5 300 73 the the DT cord-004862-yv76yvy5 300 74 highly highly RB cord-004862-yv76yvy5 300 75 repeated repeat VBN cord-004862-yv76yvy5 300 76 DNA DNA NNP cord-004862-yv76yvy5 300 77 LI LI NNP cord-004862-yv76yvy5 300 78 Genomic Genomic NNP cord-004862-yv76yvy5 300 79 sequencing sequencing NN cord-004862-yv76yvy5 300 80 Structure Structure NNP cord-004862-yv76yvy5 300 81 of of IN cord-004862-yv76yvy5 300 82 the the DT cord-004862-yv76yvy5 300 83 highly highly RB cord-004862-yv76yvy5 300 84 repeated repeat VBN cord-004862-yv76yvy5 300 85 , , , cord-004862-yv76yvy5 300 86 long long RB cord-004862-yv76yvy5 300 87 interspersed intersperse VBN cord-004862-yv76yvy5 300 88 18 18 CD cord-004862-yv76yvy5 300 89 DNA dna NN cord-004862-yv76yvy5 300 90 family family NN cord-004862-yv76yvy5 300 91 ( ( -LRB- cord-004862-yv76yvy5 300 92 LINE LINE NNP cord-004862-yv76yvy5 300 93 or or CC cord-004862-yv76yvy5 300 94 L1Rn l1rn CD cord-004862-yv76yvy5 300 95 ) ) -RRB- cord-004862-yv76yvy5 300 96 of of IN cord-004862-yv76yvy5 300 97 the the DT cord-004862-yv76yvy5 300 98 rat rat NN cord-004862-yv76yvy5 300 99 Long Long NNP cord-004862-yv76yvy5 300 100 interspersed intersperse VBD cord-004862-yv76yvy5 300 101 L1 L1 NNP cord-004862-yv76yvy5 300 102 repeats repeat VBZ cord-004862-yv76yvy5 300 103 in in IN cord-004862-yv76yvy5 300 104 rabbit rabbit NN cord-004862-yv76yvy5 300 105 DNA dna NN cord-004862-yv76yvy5 300 106 are be VBP cord-004862-yv76yvy5 300 107 homologous homologous JJ cord-004862-yv76yvy5 300 108 to to IN cord-004862-yv76yvy5 300 109 L1 L1 NNP cord-004862-yv76yvy5 300 110 repeats repeat NNS cord-004862-yv76yvy5 300 111 of of IN cord-004862-yv76yvy5 300 112 rodents rodent NNS cord-004862-yv76yvy5 300 113 and and CC cord-004862-yv76yvy5 300 114 primates primate NNS cord-004862-yv76yvy5 300 115 in in IN cord-004862-yv76yvy5 301 1 an an DT cord-004862-yv76yvy5 301 2 open open JJ cord-004862-yv76yvy5 301 3 - - HYPH cord-004862-yv76yvy5 301 4 reading read VBG cord-004862-yv76yvy5 301 5 - - HYPH cord-004862-yv76yvy5 301 6 frame frame NN cord-004862-yv76yvy5 301 7 region region NN cord-004862-yv76yvy5 301 8 Related relate VBN cord-004862-yv76yvy5 301 9 polypeptides polypeptide NNS cord-004862-yv76yvy5 301 10 are be VBP cord-004862-yv76yvy5 301 11 encoded encode VBN cord-004862-yv76yvy5 301 12 by by IN cord-004862-yv76yvy5 301 13 Drosophila Drosophila NNP cord-004862-yv76yvy5 301 14 F F NNP cord-004862-yv76yvy5 301 15 elements element NNS cord-004862-yv76yvy5 301 16 , , , cord-004862-yv76yvy5 301 17 I -PRON- PRP cord-004862-yv76yvy5 301 18 factors factor NNS cord-004862-yv76yvy5 301 19 , , , cord-004862-yv76yvy5 301 20 and and CC cord-004862-yv76yvy5 301 21 mammalian mammalian JJ cord-004862-yv76yvy5 301 22 L1 L1 NNP cord-004862-yv76yvy5 301 23 repeats repeat VBZ cord-004862-yv76yvy5 301 24 Insertion insertion NN cord-004862-yv76yvy5 301 25 of of IN cord-004862-yv76yvy5 301 26 long long JJ cord-004862-yv76yvy5 301 27 interspersed intersperse VBN cord-004862-yv76yvy5 301 28 repeated repeat VBN cord-004862-yv76yvy5 301 29 elements element NNS cord-004862-yv76yvy5 301 30 at at IN cord-004862-yv76yvy5 301 31 the the DT cord-004862-yv76yvy5 301 32 lgh lgh NNP cord-004862-yv76yvy5 301 33 ( ( -LRB- cord-004862-yv76yvy5 301 34 immunoglobulin immunoglobulin NN cord-004862-yv76yvy5 301 35 heavy heavy JJ cord-004862-yv76yvy5 301 36 chain chain NN cord-004862-yv76yvy5 301 37 ) ) -RRB- cord-004862-yv76yvy5 301 38 and and CC cord-004862-yv76yvy5 301 39 Mlvi-2 Mlvi-2 NNP cord-004862-yv76yvy5 302 1 ( ( -LRB- cord-004862-yv76yvy5 302 2 Moloney Moloney NNP cord-004862-yv76yvy5 302 3 leukemia leukemia NN cord-004862-yv76yvy5 302 4 virus virus NN cord-004862-yv76yvy5 302 5 integration integration NN cord-004862-yv76yvy5 302 6 2 2 CD cord-004862-yv76yvy5 302 7 ) ) -RRB- cord-004862-yv76yvy5 302 8 loci locus NNS cord-004862-yv76yvy5 302 9 of of IN cord-004862-yv76yvy5 302 10 rats rat NNS cord-004862-yv76yvy5 303 1 Characterization characterization NN cord-004862-yv76yvy5 303 2 ofa ofa VBP cord-004862-yv76yvy5 303 3 highly highly RB cord-004862-yv76yvy5 303 4 repetitive repetitive JJ cord-004862-yv76yvy5 303 5 family family NN cord-004862-yv76yvy5 303 6 of of IN cord-004862-yv76yvy5 303 7 DNA dna NN cord-004862-yv76yvy5 303 8 sequences sequence NNS cord-004862-yv76yvy5 303 9 in in IN cord-004862-yv76yvy5 303 10 the the DT cord-004862-yv76yvy5 303 11 mouse mouse NN cord-004862-yv76yvy5 304 1 The the DT cord-004862-yv76yvy5 304 2 LINE-1 LINE-1 NNP cord-004862-yv76yvy5 304 3 DNA dna NN cord-004862-yv76yvy5 304 4 sequences sequence NNS cord-004862-yv76yvy5 304 5 in in IN cord-004862-yv76yvy5 304 6 four four CD cord-004862-yv76yvy5 304 7 mammalian mammalian JJ cord-004862-yv76yvy5 304 8 orders order NNS cord-004862-yv76yvy5 304 9 predict predict VBP cord-004862-yv76yvy5 304 10 proteins protein NNS cord-004862-yv76yvy5 304 11 thin thin JJ cord-004862-yv76yvy5 304 12 conserve conserve VBP cord-004862-yv76yvy5 304 13 homologies homology NNS cord-004862-yv76yvy5 304 14 to to IN cord-004862-yv76yvy5 304 15 retrovirus retrovirus NN cord-004862-yv76yvy5 304 16 proteins protein NNS cord-004862-yv76yvy5 305 1 Transposable transposable JJ cord-004862-yv76yvy5 305 2 elements element NNS cord-004862-yv76yvy5 305 3 controlling control VBG cord-004862-yv76yvy5 305 4 I I NNP cord-004862-yv76yvy5 305 5 - - HYPH cord-004862-yv76yvy5 305 6 R r NN cord-004862-yv76yvy5 305 7 hybrid hybrid NN cord-004862-yv76yvy5 305 8 dysgenesis dysgenesis NN cord-004862-yv76yvy5 305 9 in in IN cord-004862-yv76yvy5 305 10 D. D. NNP cord-004862-yv76yvy5 305 11 metanogaster metanogaster NNP cord-004862-yv76yvy5 305 12 are be VBP cord-004862-yv76yvy5 305 13 similar similar JJ cord-004862-yv76yvy5 305 14 to to IN cord-004862-yv76yvy5 305 15 mammalian mammalian JJ cord-004862-yv76yvy5 305 16 LINEs line NNS cord-004862-yv76yvy5 305 17 Defining define VBG cord-004862-yv76yvy5 305 18 the the DT cord-004862-yv76yvy5 305 19 beginning beginning NN cord-004862-yv76yvy5 305 20 and and CC cord-004862-yv76yvy5 305 21 end end NN cord-004862-yv76yvy5 305 22 of of IN cord-004862-yv76yvy5 305 23 KpnI KpnI NNP cord-004862-yv76yvy5 305 24 family family NN cord-004862-yv76yvy5 305 25 segments segment NNS cord-004862-yv76yvy5 305 26 Evolution evolution NN cord-004862-yv76yvy5 305 27 of of IN cord-004862-yv76yvy5 305 28 the the DT cord-004862-yv76yvy5 305 29 mammalian mammalian JJ cord-004862-yv76yvy5 305 30 fl fl NNP cord-004862-yv76yvy5 305 31 - - HYPH cord-004862-yv76yvy5 305 32 globin globin NN cord-004862-yv76yvy5 305 33 gene gene NN cord-004862-yv76yvy5 305 34 cluster cluster NN cord-004862-yv76yvy5 305 35 Comparison comparison NN cord-004862-yv76yvy5 305 36 of of IN cord-004862-yv76yvy5 305 37 the the DT cord-004862-yv76yvy5 305 38 ~8 ~8 NNP cord-004862-yv76yvy5 305 39 - - HYPH cord-004862-yv76yvy5 305 40 1ike 1ike CD cord-004862-yv76yvy5 305 41 globin globin NN cord-004862-yv76yvy5 305 42 gene gene NN cord-004862-yv76yvy5 305 43 families family NNS cord-004862-yv76yvy5 305 44 of of IN cord-004862-yv76yvy5 305 45 rabbits rabbit NNS cord-004862-yv76yvy5 305 46 and and CC cord-004862-yv76yvy5 305 47 humans human NNS cord-004862-yv76yvy5 305 48 indicates indicate VBZ cord-004862-yv76yvy5 305 49 that that IN cord-004862-yv76yvy5 305 50 the the DT cord-004862-yv76yvy5 305 51 gene gene NN cord-004862-yv76yvy5 305 52 cluster cluster NN cord-004862-yv76yvy5 305 53 5'-~-3'-fi 5'-~-3'-fi CD cord-004862-yv76yvy5 305 54 - - HYPH cord-004862-yv76yvy5 305 55 fl-3 fl-3 NNP cord-004862-yv76yvy5 305 56 ' ' '' cord-004862-yv76yvy5 305 57 predates predate VBZ cord-004862-yv76yvy5 305 58 the the DT cord-004862-yv76yvy5 305 59 mammalian mammalian JJ cord-004862-yv76yvy5 305 60 radiation radiation NN cord-004862-yv76yvy5 305 61 Efstratiadis Efstratiadis NNP cord-004862-yv76yvy5 305 62 A A NNP cord-004862-yv76yvy5 305 63 ( ( -LRB- cord-004862-yv76yvy5 305 64 1979 1979 CD cord-004862-yv76yvy5 305 65 ) ) -RRB- cord-004862-yv76yvy5 306 1 The the DT cord-004862-yv76yvy5 306 2 structure structure NN cord-004862-yv76yvy5 306 3 and and CC cord-004862-yv76yvy5 306 4 transcription transcription NN cord-004862-yv76yvy5 306 5 of of IN cord-004862-yv76yvy5 306 6 four four CD cord-004862-yv76yvy5 306 7 linked link VBN cord-004862-yv76yvy5 307 1 rabbit/~-like rabbit/~-like : cord-004862-yv76yvy5 307 2 globin globin NN cord-004862-yv76yvy5 307 3 genes gene NNS cord-004862-yv76yvy5 307 4 Sequence Sequence NNP cord-004862-yv76yvy5 307 5 analysis analysis NN cord-004862-yv76yvy5 307 6 of of IN cord-004862-yv76yvy5 307 7 a a DT cord-004862-yv76yvy5 307 8 KpnI KpnI NNP cord-004862-yv76yvy5 307 9 family family NN cord-004862-yv76yvy5 307 10 member member NN cord-004862-yv76yvy5 307 11 near near IN cord-004862-yv76yvy5 307 12 the the DT cord-004862-yv76yvy5 307 13 3 3 CD cord-004862-yv76yvy5 307 14 ' ' NN cord-004862-yv76yvy5 307 15 end end NN cord-004862-yv76yvy5 307 16 of of IN cord-004862-yv76yvy5 307 17 human human JJ cord-004862-yv76yvy5 307 18 fl fl JJ cord-004862-yv76yvy5 307 19 - - HYPH cord-004862-yv76yvy5 307 20 globin globin NN cord-004862-yv76yvy5 307 21 gene gene NN cord-004862-yv76yvy5 307 22 LI LI NNP cord-004862-yv76yvy5 307 23 family family NN cord-004862-yv76yvy5 307 24 of of IN cord-004862-yv76yvy5 307 25 repetitive repetitive JJ cord-004862-yv76yvy5 307 26 DNA dna NN cord-004862-yv76yvy5 307 27 sequences sequence NNS cord-004862-yv76yvy5 307 28 in in IN cord-004862-yv76yvy5 307 29 primates primate NNS cord-004862-yv76yvy5 307 30 may may MD cord-004862-yv76yvy5 307 31 be be VB cord-004862-yv76yvy5 307 32 derived derive VBN cord-004862-yv76yvy5 307 33 from from IN cord-004862-yv76yvy5 307 34 a a DT cord-004862-yv76yvy5 307 35 sequence sequence NN cord-004862-yv76yvy5 307 36 encoding encode VBG cord-004862-yv76yvy5 307 37 a a DT cord-004862-yv76yvy5 307 38 reverse reverse JJ cord-004862-yv76yvy5 307 39 transcriptase transcriptase NN cord-004862-yv76yvy5 307 40 - - HYPH cord-004862-yv76yvy5 307 41 related relate VBN cord-004862-yv76yvy5 307 42 protein protein NN cord-004862-yv76yvy5 307 43 Structure structure NN cord-004862-yv76yvy5 307 44 ofa ofa NN cord-004862-yv76yvy5 307 45 gene gene NN cord-004862-yv76yvy5 307 46 for for IN cord-004862-yv76yvy5 307 47 the the DT cord-004862-yv76yvy5 307 48 human human JJ cord-004862-yv76yvy5 307 49 epidermal epidermal JJ cord-004862-yv76yvy5 307 50 67-kDa 67-kda CD cord-004862-yv76yvy5 307 51 keratin keratin NN cord-004862-yv76yvy5 307 52 Retroposon Retroposon NNP cord-004862-yv76yvy5 307 53 " " '' cord-004862-yv76yvy5 307 54 insertion insertion NN cord-004862-yv76yvy5 307 55 into into IN cord-004862-yv76yvy5 307 56 the the DT cord-004862-yv76yvy5 307 57 cellular cellular JJ cord-004862-yv76yvy5 307 58 oncogene oncogene NN cord-004862-yv76yvy5 307 59 c c NN cord-004862-yv76yvy5 307 60 - - HYPH cord-004862-yv76yvy5 307 61 myc myc NNP cord-004862-yv76yvy5 307 62 in in IN cord-004862-yv76yvy5 307 63 canine canine JJ cord-004862-yv76yvy5 307 64 transmissible transmissible JJ cord-004862-yv76yvy5 307 65 venereal venereal NN cord-004862-yv76yvy5 307 66 tumor tumor NN cord-004862-yv76yvy5 307 67 Ingi Ingi NNP cord-004862-yv76yvy5 307 68 , , , cord-004862-yv76yvy5 307 69 a a DT cord-004862-yv76yvy5 307 70 5.2-kb 5.2-kb CD cord-004862-yv76yvy5 307 71 dispersed disperse VBN cord-004862-yv76yvy5 307 72 sequence sequence NN cord-004862-yv76yvy5 307 73 element element NN cord-004862-yv76yvy5 307 74 from from IN cord-004862-yv76yvy5 307 75 Trypanosoma Trypanosoma NNP cord-004862-yv76yvy5 307 76 brucei brucei NNP cord-004862-yv76yvy5 307 77 that that WDT cord-004862-yv76yvy5 307 78 carries carry VBZ cord-004862-yv76yvy5 307 79 half half NN cord-004862-yv76yvy5 307 80 of of IN cord-004862-yv76yvy5 307 81 a a DT cord-004862-yv76yvy5 307 82 smaller small JJR cord-004862-yv76yvy5 307 83 mobile mobile JJ cord-004862-yv76yvy5 307 84 element element NN cord-004862-yv76yvy5 307 85 at at IN cord-004862-yv76yvy5 307 86 either either DT cord-004862-yv76yvy5 307 87 end end NN cord-004862-yv76yvy5 307 88 and and CC cord-004862-yv76yvy5 307 89 has have VBZ cord-004862-yv76yvy5 307 90 homology homology NN cord-004862-yv76yvy5 307 91 with with IN cord-004862-yv76yvy5 307 92 mammalian mammalian JJ cord-004862-yv76yvy5 307 93 LINEs line NNS cord-004862-yv76yvy5 307 94 Human Human NNP cord-004862-yv76yvy5 307 95 genome genome NN cord-004862-yv76yvy5 307 96 organization organization NN cord-004862-yv76yvy5 307 97 : : : cord-004862-yv76yvy5 307 98 Alu Alu NNP cord-004862-yv76yvy5 307 99 , , , cord-004862-yv76yvy5 307 100 Lines Lines NNP cord-004862-yv76yvy5 307 101 , , , cord-004862-yv76yvy5 307 102 and and CC cord-004862-yv76yvy5 307 103 the the DT cord-004862-yv76yvy5 307 104 molecular molecular JJ cord-004862-yv76yvy5 307 105 structure structure NN cord-004862-yv76yvy5 307 106 of of IN cord-004862-yv76yvy5 307 107 metaphase metaphase NN cord-004862-yv76yvy5 307 108 chromosome chromosome NN cord-004862-yv76yvy5 307 109 bands band NNS cord-004862-yv76yvy5 308 1 The the DT cord-004862-yv76yvy5 308 2 nucleotide nucleotide JJ cord-004862-yv76yvy5 308 3 sequence sequence NN cord-004862-yv76yvy5 308 4 of of IN cord-004862-yv76yvy5 308 5 a a DT cord-004862-yv76yvy5 308 6 rabbit rabbit NN cord-004862-yv76yvy5 308 7 fl fl NNP cord-004862-yv76yvy5 308 8 - - HYPH cord-004862-yv76yvy5 308 9 giobin giobin NNP cord-004862-yv76yvy5 308 10 pseudogene pseudogene NNP cord-004862-yv76yvy5 308 11 Linkage Linkage NNP cord-004862-yv76yvy5 308 12 arrangement arrangement NN cord-004862-yv76yvy5 308 13 of of IN cord-004862-yv76yvy5 308 14 four four CD cord-004862-yv76yvy5 308 15 rabbit rabbit NN cord-004862-yv76yvy5 308 16 fl fl NNP cord-004862-yv76yvy5 308 17 - - HYPH cord-004862-yv76yvy5 308 18 like like JJ cord-004862-yv76yvy5 308 19 giobin giobin NNP cord-004862-yv76yvy5 308 20 genes gene NNS cord-004862-yv76yvy5 308 21 KpnI KpnI NNP cord-004862-yv76yvy5 308 22 family family NN cord-004862-yv76yvy5 308 23 of of IN cord-004862-yv76yvy5 308 24 long long RB cord-004862-yv76yvy5 308 25 interspersed intersperse VBN cord-004862-yv76yvy5 308 26 repeated repeat VBN cord-004862-yv76yvy5 308 27 DNA dna NN cord-004862-yv76yvy5 308 28 sequences sequence NNS cord-004862-yv76yvy5 308 29 in in IN cord-004862-yv76yvy5 308 30 primates primate NNS cord-004862-yv76yvy5 308 31 : : : cord-004862-yv76yvy5 308 32 polymorphism polymorphism NN cord-004862-yv76yvy5 308 33 of of IN cord-004862-yv76yvy5 308 34 family family NN cord-004862-yv76yvy5 308 35 members member NNS cord-004862-yv76yvy5 308 36 and and CC cord-004862-yv76yvy5 308 37 evidence evidence NN cord-004862-yv76yvy5 308 38 for for IN cord-004862-yv76yvy5 308 39 transcription transcription NN cord-004862-yv76yvy5 308 40 Rapid Rapid NNP cord-004862-yv76yvy5 308 41 and and CC cord-004862-yv76yvy5 308 42 sensitive sensitive JJ cord-004862-yv76yvy5 308 43 protein protein NN cord-004862-yv76yvy5 308 44 similarity similarity NN cord-004862-yv76yvy5 308 45 searches search NNS cord-004862-yv76yvy5 309 1 The the DT cord-004862-yv76yvy5 309 2 sequence sequence NN cord-004862-yv76yvy5 309 3 of of IN cord-004862-yv76yvy5 309 4 a a DT cord-004862-yv76yvy5 309 5 large large JJ cord-004862-yv76yvy5 309 6 L l NN cord-004862-yv76yvy5 309 7 1Md 1md JJ cord-004862-yv76yvy5 309 8 element element NN cord-004862-yv76yvy5 309 9 reveals reveal VBZ cord-004862-yv76yvy5 309 10 a a DT cord-004862-yv76yvy5 309 11 tandemly tandemly NN cord-004862-yv76yvy5 309 12 repeated repeat VBN cord-004862-yv76yvy5 309 13 5 5 CD cord-004862-yv76yvy5 309 14 ' ' NN cord-004862-yv76yvy5 309 15 end end NN cord-004862-yv76yvy5 309 16 and and CC cord-004862-yv76yvy5 309 17 several several JJ cord-004862-yv76yvy5 309 18 features feature NNS cord-004862-yv76yvy5 309 19 found find VBN cord-004862-yv76yvy5 309 20 in in IN cord-004862-yv76yvy5 309 21 retrotransposons retrotransposon NNS cord-004862-yv76yvy5 310 1 The the DT cord-004862-yv76yvy5 310 2 isolation isolation NN cord-004862-yv76yvy5 310 3 of of IN cord-004862-yv76yvy5 310 4 structural structural JJ cord-004862-yv76yvy5 310 5 genes gene NNS cord-004862-yv76yvy5 310 6 from from IN cord-004862-yv76yvy5 310 7 libraries library NNS cord-004862-yv76yvy5 310 8 of of IN cord-004862-yv76yvy5 310 9 eucaryotic eucaryotic JJ cord-004862-yv76yvy5 310 10 DNA DNA NNP cord-004862-yv76yvy5 310 11 Nucleotide Nucleotide NNP cord-004862-yv76yvy5 310 12 sequence sequence NN cord-004862-yv76yvy5 310 13 definition definition NN cord-004862-yv76yvy5 310 14 ofa ofa DT cord-004862-yv76yvy5 310 15 major major JJ cord-004862-yv76yvy5 310 16 human human JJ cord-004862-yv76yvy5 310 17 repeated repeat VBN cord-004862-yv76yvy5 310 18 DNA DNA NNP cord-004862-yv76yvy5 310 19 , , , cord-004862-yv76yvy5 310 20 the the DT cord-004862-yv76yvy5 310 21 HindlII HindlII NNP cord-004862-yv76yvy5 310 22 1.9 1.9 CD cord-004862-yv76yvy5 310 23 kb kb NNP cord-004862-yv76yvy5 310 24 family family NN cord-004862-yv76yvy5 310 25 Complete complete JJ cord-004862-yv76yvy5 310 26 nucleotide nucleotide JJ cord-004862-yv76yvy5 310 27 sequence sequence NN cord-004862-yv76yvy5 310 28 of of IN cord-004862-yv76yvy5 310 29 the the DT cord-004862-yv76yvy5 310 30 rabbit rabbit NN cord-004862-yv76yvy5 310 31 fl fl NNP cord-004862-yv76yvy5 310 32 - - HYPH cord-004862-yv76yvy5 310 33 like like JJ cord-004862-yv76yvy5 310 34 globin globin NN cord-004862-yv76yvy5 310 35 gene gene NN cord-004862-yv76yvy5 310 36 cluster cluster NN cord-004862-yv76yvy5 310 37 : : : cord-004862-yv76yvy5 310 38 analysis analysis NN cord-004862-yv76yvy5 310 39 of of IN cord-004862-yv76yvy5 310 40 intergenic intergenic JJ cord-004862-yv76yvy5 310 41 sequences sequence NNS cord-004862-yv76yvy5 310 42 and and CC cord-004862-yv76yvy5 310 43 comparison comparison NN cord-004862-yv76yvy5 310 44 with with IN cord-004862-yv76yvy5 310 45 human human JJ cord-004862-yv76yvy5 310 46 fl fl NNP cord-004862-yv76yvy5 310 47 - - HYPH cord-004862-yv76yvy5 310 48 like like JJ cord-004862-yv76yvy5 310 49 globin globin NN cord-004862-yv76yvy5 310 50 gene gene NN cord-004862-yv76yvy5 310 51 cluster cluster NN cord-004862-yv76yvy5 311 1 A a DT cord-004862-yv76yvy5 311 2 large large JJ cord-004862-yv76yvy5 311 3 interspersed intersperse VBN cord-004862-yv76yvy5 311 4 repeal repeal NN cord-004862-yv76yvy5 311 5 found find VBN cord-004862-yv76yvy5 311 6 in in IN cord-004862-yv76yvy5 311 7 mouse mouse NN cord-004862-yv76yvy5 311 8 DNA DNA NNP cord-004862-yv76yvy5 311 9 contains contain VBZ cord-004862-yv76yvy5 311 10 a a DT cord-004862-yv76yvy5 311 11 long long JJ cord-004862-yv76yvy5 311 12 open open JJ cord-004862-yv76yvy5 311 13 reading reading NN cord-004862-yv76yvy5 311 14 frame frame NN cord-004862-yv76yvy5 311 15 that that WDT cord-004862-yv76yvy5 311 16 evolves evolve VBZ cord-004862-yv76yvy5 311 17 as as IN cord-004862-yv76yvy5 311 18 if if IN cord-004862-yv76yvy5 311 19 it -PRON- PRP cord-004862-yv76yvy5 311 20 encodes encode VBZ cord-004862-yv76yvy5 311 21 a a DT cord-004862-yv76yvy5 311 22 protein protein NN cord-004862-yv76yvy5 311 23 New New NNP cord-004862-yv76yvy5 311 24 M13 M13 NNP cord-004862-yv76yvy5 311 25 vectors vector NNS cord-004862-yv76yvy5 311 26 for for IN cord-004862-yv76yvy5 311 27 cloning clone VBG cord-004862-yv76yvy5 311 28 A a DT cord-004862-yv76yvy5 311 29 transposon transposon NN cord-004862-yv76yvy5 311 30 - - HYPH cord-004862-yv76yvy5 311 31 like like JJ cord-004862-yv76yvy5 311 32 element element NN cord-004862-yv76yvy5 311 33 in in IN cord-004862-yv76yvy5 311 34 human human JJ cord-004862-yv76yvy5 311 35 DNA dna NN cord-004862-yv76yvy5 311 36 Rearranged rearrange VBN cord-004862-yv76yvy5 311 37 sequence sequence NN cord-004862-yv76yvy5 311 38 of of IN cord-004862-yv76yvy5 311 39 a a DT cord-004862-yv76yvy5 311 40 human human JJ cord-004862-yv76yvy5 311 41 KpnI KpnI NNP cord-004862-yv76yvy5 311 42 element element NN cord-004862-yv76yvy5 311 43 Labeling label VBG cord-004862-yv76yvy5 311 44 deoxyribonucleic deoxyribonucleic NN cord-004862-yv76yvy5 311 45 acid acid NN cord-004862-yv76yvy5 311 46 to to IN cord-004862-yv76yvy5 311 47 high high JJ cord-004862-yv76yvy5 311 48 specific specific JJ cord-004862-yv76yvy5 311 49 activity activity NN cord-004862-yv76yvy5 311 50 in in IN cord-004862-yv76yvy5 311 51 vitro vitro FW cord-004862-yv76yvy5 311 52 by by IN cord-004862-yv76yvy5 311 53 nick nick NNP cord-004862-yv76yvy5 311 54 translation translation NN cord-004862-yv76yvy5 311 55 with with IN cord-004862-yv76yvy5 311 56 DNA dna NN cord-004862-yv76yvy5 311 57 polymerase polymerase NN cord-004862-yv76yvy5 312 1 I -PRON- PRP cord-004862-yv76yvy5 312 2 Retroposons Retroposons NNP cord-004862-yv76yvy5 312 3 defined define VBD cord-004862-yv76yvy5 312 4 Analysis Analysis NNP cord-004862-yv76yvy5 312 5 of of IN cord-004862-yv76yvy5 312 6 rabbit rabbit NNP cord-004862-yv76yvy5 312 7 fl fl NNP cord-004862-yv76yvy5 312 8 - - HYPH cord-004862-yv76yvy5 312 9 like like JJ cord-004862-yv76yvy5 312 10 globin globin NN cord-004862-yv76yvy5 312 11 gene gene NN cord-004862-yv76yvy5 312 12 transcripts transcript NNS cord-004862-yv76yvy5 312 13 during during IN cord-004862-yv76yvy5 312 14 development development NN cord-004862-yv76yvy5 312 15 Transcription Transcription NNP cord-004862-yv76yvy5 312 16 unit unit NN cord-004862-yv76yvy5 312 17 of of IN cord-004862-yv76yvy5 312 18 rabbit rabbit NNP cord-004862-yv76yvy5 312 19 fl fl NNP cord-004862-yv76yvy5 312 20 I I NNP cord-004862-yv76yvy5 312 21 - - HYPH cord-004862-yv76yvy5 312 22 globin globin NN cord-004862-yv76yvy5 312 23 gene gene NN cord-004862-yv76yvy5 312 24 DNA dna NN cord-004862-yv76yvy5 312 25 sequencing sequencing NN cord-004862-yv76yvy5 312 26 with with IN cord-004862-yv76yvy5 312 27 chain chain NN cord-004862-yv76yvy5 312 28 - - HYPH cord-004862-yv76yvy5 312 29 terminating terminate VBG cord-004862-yv76yvy5 312 30 inhibitors inhibitor NNS cord-004862-yv76yvy5 312 31 Origin Origin NNP cord-004862-yv76yvy5 312 32 of of IN cord-004862-yv76yvy5 312 33 the the DT cord-004862-yv76yvy5 312 34 human human JJ cord-004862-yv76yvy5 312 35 LI LI NNP cord-004862-yv76yvy5 312 36 elements element NNS cord-004862-yv76yvy5 312 37 : : : cord-004862-yv76yvy5 312 38 proposed propose VBN cord-004862-yv76yvy5 312 39 progenitor progenitor NN cord-004862-yv76yvy5 312 40 genes gene NNS cord-004862-yv76yvy5 312 41 deduced deduce VBN cord-004862-yv76yvy5 312 42 from from IN cord-004862-yv76yvy5 312 43 a a DT cord-004862-yv76yvy5 312 44 consensus consensus NN cord-004862-yv76yvy5 312 45 DNA dna NN cord-004862-yv76yvy5 312 46 sequence sequence NN cord-004862-yv76yvy5 312 47 Determination determination NN cord-004862-yv76yvy5 312 48 of of IN cord-004862-yv76yvy5 312 49 a a DT cord-004862-yv76yvy5 312 50 functional functional JJ cord-004862-yv76yvy5 312 51 ancestral ancestral JJ cord-004862-yv76yvy5 312 52 sequence sequence NN cord-004862-yv76yvy5 312 53 and and CC cord-004862-yv76yvy5 312 54 definition definition NN cord-004862-yv76yvy5 312 55 of of IN cord-004862-yv76yvy5 312 56 the the DT cord-004862-yv76yvy5 312 57 5 5 CD cord-004862-yv76yvy5 312 58 ' ' NN cord-004862-yv76yvy5 312 59 end end NN cord-004862-yv76yvy5 312 60 of of IN cord-004862-yv76yvy5 312 61 A a DT cord-004862-yv76yvy5 312 62 - - HYPH cord-004862-yv76yvy5 312 63 type type NN cord-004862-yv76yvy5 312 64 mouse mouse NN cord-004862-yv76yvy5 312 65 LI LI NNP cord-004862-yv76yvy5 312 66 elements element NNS cord-004862-yv76yvy5 312 67 The the DT cord-004862-yv76yvy5 312 68 nucleotide nucleotide JJ cord-004862-yv76yvy5 312 69 sequence sequence NN cord-004862-yv76yvy5 312 70 of of IN cord-004862-yv76yvy5 312 71 the the DT cord-004862-yv76yvy5 312 72 BALB BALB NNP cord-004862-yv76yvy5 312 73 / / SYM cord-004862-yv76yvy5 312 74 C C NNP cord-004862-yv76yvy5 312 75 mouse mouse NNP cord-004862-yv76yvy5 312 76 fl fl NNP cord-004862-yv76yvy5 312 77 - - HYPH cord-004862-yv76yvy5 312 78 globin globin NN cord-004862-yv76yvy5 312 79 complex complex NN cord-004862-yv76yvy5 313 1 The the DT cord-004862-yv76yvy5 313 2 organization organization NN cord-004862-yv76yvy5 313 3 of of IN cord-004862-yv76yvy5 313 4 repetitive repetitive JJ cord-004862-yv76yvy5 313 5 sequences sequence NNS cord-004862-yv76yvy5 313 6 in in IN cord-004862-yv76yvy5 313 7 a a DT cord-004862-yv76yvy5 313 8 cluster cluster NN cord-004862-yv76yvy5 313 9 of of IN cord-004862-yv76yvy5 313 10 rabbit rabbit NN cord-004862-yv76yvy5 313 11 fl fl NNP cord-004862-yv76yvy5 313 12 - - HYPH cord-004862-yv76yvy5 313 13 like like JJ cord-004862-yv76yvy5 313 14 globin globin NN cord-004862-yv76yvy5 313 15 genes gene NNS cord-004862-yv76yvy5 313 16 SINEs sine NNS cord-004862-yv76yvy5 313 17 and and CC cord-004862-yv76yvy5 313 18 LINEs line NNS cord-004862-yv76yvy5 313 19 : : : cord-004862-yv76yvy5 313 20 highly highly RB cord-004862-yv76yvy5 313 21 repeated repeat VBN cord-004862-yv76yvy5 313 22 short short JJ cord-004862-yv76yvy5 313 23 and and CC cord-004862-yv76yvy5 313 24 long long JJ cord-004862-yv76yvy5 313 25 interspersed interspersed JJ cord-004862-yv76yvy5 313 26 sequences sequence NNS cord-004862-yv76yvy5 313 27 in in IN cord-004862-yv76yvy5 313 28 mammalian mammalian JJ cord-004862-yv76yvy5 313 29 genomes genome NNS cord-004862-yv76yvy5 313 30 Making make VBG cord-004862-yv76yvy5 313 31 sense sense NN cord-004862-yv76yvy5 313 32 out out IN cord-004862-yv76yvy5 313 33 of of IN cord-004862-yv76yvy5 313 34 LINEs line NNS cord-004862-yv76yvy5 313 35 : : : cord-004862-yv76yvy5 313 36 long long RB cord-004862-yv76yvy5 313 37 interspersed intersperse VBN cord-004862-yv76yvy5 313 38 repeat repeat NN cord-004862-yv76yvy5 313 39 sequences sequence NNS cord-004862-yv76yvy5 313 40 in in IN cord-004862-yv76yvy5 313 41 mammalian mammalian JJ cord-004862-yv76yvy5 313 42 genomes genome NNS cord-004862-yv76yvy5 313 43 Expression expression NN cord-004862-yv76yvy5 313 44 of of IN cord-004862-yv76yvy5 313 45 a a DT cord-004862-yv76yvy5 313 46 cytoplasmic cytoplasmic JJ cord-004862-yv76yvy5 313 47 LINE-1 LINE-1 NNP cord-004862-yv76yvy5 313 48 transcript transcript NN cord-004862-yv76yvy5 313 49 is be VBZ cord-004862-yv76yvy5 313 50 regulated regulate VBN cord-004862-yv76yvy5 313 51 in in IN cord-004862-yv76yvy5 313 52 a a DT cord-004862-yv76yvy5 313 53 human human JJ cord-004862-yv76yvy5 313 54 teratocarcinoma teratocarcinoma NNP cord-004862-yv76yvy5 313 55 cell cell NN cord-004862-yv76yvy5 313 56 line line NN cord-004862-yv76yvy5 313 57 Rat Rat NNP cord-004862-yv76yvy5 313 58 LINEI LINEI NNP cord-004862-yv76yvy5 313 59 : : : cord-004862-yv76yvy5 313 60 the the DT cord-004862-yv76yvy5 313 61 origin origin NN cord-004862-yv76yvy5 313 62 and and CC cord-004862-yv76yvy5 313 63 evolution evolution NN cord-004862-yv76yvy5 313 64 of of IN cord-004862-yv76yvy5 313 65 a a DT cord-004862-yv76yvy5 313 66 family family NN cord-004862-yv76yvy5 313 67 of of IN cord-004862-yv76yvy5 313 68 long long RB cord-004862-yv76yvy5 313 69 interspersed intersperse VBN cord-004862-yv76yvy5 313 70 middle middle JJ cord-004862-yv76yvy5 313 71 repetitive repetitive JJ cord-004862-yv76yvy5 313 72 DNA dna NN cord-004862-yv76yvy5 313 73 elements element NNS cord-004862-yv76yvy5 313 74 Detection detection NN cord-004862-yv76yvy5 313 75 of of IN cord-004862-yv76yvy5 313 76 specific specific JJ cord-004862-yv76yvy5 313 77 sequences sequence NNS cord-004862-yv76yvy5 313 78 among among IN cord-004862-yv76yvy5 313 79 DNA dna NN cord-004862-yv76yvy5 313 80 fragments fragment NNS cord-004862-yv76yvy5 313 81 separated separate VBN cord-004862-yv76yvy5 313 82 by by IN cord-004862-yv76yvy5 313 83 gel gel NN cord-004862-yv76yvy5 313 84 electrophoresis electrophoresis NN cord-004862-yv76yvy5 314 1 The the DT cord-004862-yv76yvy5 314 2 L1Md L1Md NNP cord-004862-yv76yvy5 314 3 long long RB cord-004862-yv76yvy5 314 4 interspersed intersperse VBN cord-004862-yv76yvy5 314 5 repeat repeat VBP cord-004862-yv76yvy5 314 6 family family NN cord-004862-yv76yvy5 314 7 in in IN cord-004862-yv76yvy5 314 8 the the DT cord-004862-yv76yvy5 314 9 mouse mouse NN cord-004862-yv76yvy5 314 10 : : : cord-004862-yv76yvy5 314 11 almost almost RB cord-004862-yv76yvy5 314 12 all all DT cord-004862-yv76yvy5 314 13 examples example NNS cord-004862-yv76yvy5 314 14 are be VBP cord-004862-yv76yvy5 314 15 truncated truncate VBN cord-004862-yv76yvy5 314 16 at at IN cord-004862-yv76yvy5 314 17 one one CD cord-004862-yv76yvy5 314 18 end end NN cord-004862-yv76yvy5 314 19 roposons roposon NNS cord-004862-yv76yvy5 314 20 : : : cord-004862-yv76yvy5 314 21 genes gene NNS cord-004862-yv76yvy5 314 22 , , , cord-004862-yv76yvy5 314 23 pseudogenes pseudogene NNS cord-004862-yv76yvy5 314 24 , , , cord-004862-yv76yvy5 314 25 and and CC cord-004862-yv76yvy5 314 26 transposable transposable JJ cord-004862-yv76yvy5 314 27 elements element NNS cord-004862-yv76yvy5 314 28 generated generate VBN cord-004862-yv76yvy5 314 29 by by IN cord-004862-yv76yvy5 314 30 the the DT cord-004862-yv76yvy5 314 31 reverse reverse JJ cord-004862-yv76yvy5 314 32 flow flow NN cord-004862-yv76yvy5 314 33 of of IN cord-004862-yv76yvy5 314 34 genetic genetic JJ cord-004862-yv76yvy5 314 35 information information NN cord-004862-yv76yvy5 314 36 Rapid rapid JJ cord-004862-yv76yvy5 314 37 similarity similarity NN cord-004862-yv76yvy5 314 38 searches search NNS cord-004862-yv76yvy5 314 39 of of IN cord-004862-yv76yvy5 314 40 nucleic nucleic JJ cord-004862-yv76yvy5 314 41 acid acid NN cord-004862-yv76yvy5 314 42 and and CC cord-004862-yv76yvy5 314 43 protein protein NN cord-004862-yv76yvy5 314 44 data datum NNS cord-004862-yv76yvy5 314 45 banks bank NNS cord-004862-yv76yvy5 315 1 The the DT cord-004862-yv76yvy5 315 2 site site NN cord-004862-yv76yvy5 315 3 - - HYPH cord-004862-yv76yvy5 315 4 specific specific JJ cord-004862-yv76yvy5 315 5 ribosomal ribosomal JJ cord-004862-yv76yvy5 315 6 DNAinsertion dnainsertion NN cord-004862-yv76yvy5 315 7 element element NN cord-004862-yv76yvy5 315 8 RIBm RIBm NNP cord-004862-yv76yvy5 315 9 belongs belong VBZ cord-004862-yv76yvy5 315 10 to to IN cord-004862-yv76yvy5 315 11 a a DT cord-004862-yv76yvy5 315 12 class class NN cord-004862-yv76yvy5 315 13 of of IN cord-004862-yv76yvy5 315 14 non non JJ cord-004862-yv76yvy5 315 15 - - JJ cord-004862-yv76yvy5 315 16 long long JJ cord-004862-yv76yvy5 315 17 - - HYPH cord-004862-yv76yvy5 315 18 terminal terminal NN cord-004862-yv76yvy5 315 19 - - HYPH cord-004862-yv76yvy5 315 20 repeat repeat NN cord-004862-yv76yvy5 315 21 retrotransposons retrotransposon NNS cord-004862-yv76yvy5 315 22 Analysis analysis NN cord-004862-yv76yvy5 315 23 of of IN cord-004862-yv76yvy5 315 24 large large JJ cord-004862-yv76yvy5 315 25 nucleic nucleic JJ cord-004862-yv76yvy5 315 26 acid acid NN cord-004862-yv76yvy5 315 27 dot dot NN cord-004862-yv76yvy5 315 28 matrices matrix NNS cord-004862-yv76yvy5 315 29 on on IN cord-004862-yv76yvy5 315 30 small small JJ cord-004862-yv76yvy5 315 31 computers computer NNS cord-004862-yv76yvy5 315 32 Acknowledgments acknowledgment NNS cord-004862-yv76yvy5 315 33 . . . cord-004862-yv76yvy5 316 1 We -PRON- PRP cord-004862-yv76yvy5 316 2 _SP