id author title date pages extension mime words sentences flesch summary cache txt cord-017258-5mzr5s22 Kanazawa, Nobuo C-Type Lectin Receptors 2015-11-30 .txt text/plain 6622 294 37 Similar to the killer lectin-like receptors whose genes are clustered in this complex, most of the CLRs induce activating or regulatory signal cascades in response to distinct pathogenor self-derived components, through the immunoreceptor tyrosine-based activating or inhibitory motif, respectively. They commonly consist of an N-terminal cysteine-rich domain and a fibronectin type II domain as well as eight or ten CTLDs. In contrast, the asialoglycoprotein receptor family (group II) contains type II transmembrane proteins with a single CTLD, such as DC-specific ICAM3-grabbing nonintegrin (DC-SIGN, CD209), dectin-1, dectin-2, DC immunoreceptor (DCIR), and macrophage-inducible C-type lectin (Mincle) [4, 5, 9, 33, 69] . Notably, expression of some receptors is specific and they can be markers for distinct DC subsets; langerin (CD207) on Langerhans cells (LCs) and blood DC antigen (BDCA)-2 (CD303) on plasmacytoid DCs (pDCs) [25, 99] . ./cache/cord-017258-5mzr5s22.txt ./txt/cord-017258-5mzr5s22.txt