id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265600-lnik974k	Celerino da Silva, Ronaldo	Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission	2011-01-26		.txt	text/plain	5511	213	45	Some PRRs located on the surface of dendritic cells (DCs) and other cells seem to play an important role in human immunodeficiency virus type 1 (HIV-1) transmission. Dendritic cell–specific intercellular adhesion molecule–3 grabbing non-integrin, CD209 (DC-SIGN) and its homolog, DC-SIGN-related (DC-SIGNR or L-SIGN) receptors are PPRs able to bind the HIV-1 gp120 envelope protein and, because alterations in their expression patterns also occur, they might play a role in both horizontal and vertical transmission as well as in disseminating the virus within the host. This review aims to explore the involvement of the dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin, CD209 (DC-SIGN) and DC-SIGN-related C-type lectin domain family 4, member M (L-SIGN) receptors in HIV-1 transmission from mother to child. Transmission of the HIV-1 virus from mother to child via breast milk can occur by free virus particles and/or viral particles associated with cells [4] ; in this case, the expression of cellular receptors for recognition and adhesion of pathogens is required.	./cache/cord-265600-lnik974k.txt	./txt/cord-265600-lnik974k.txt