id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267234-waz0k0ms	Shu, Chang	Characterization of the duplicate L-SIGN and DC-SIGN genes in miiuy croaker and evolutionary analysis of L-SIGN in fishes	2015-01-13		.txt	text/plain	4202	177	56	Dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN/CD209) and liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN/CD299) which are homologues of DC-SIGN are important members in C-type lectin receptors family as key molecules to recognize and eliminate pathogens in the innate immune system. The sequence analysis results showed that mmDC-SIGN and mmL-SIGN have the same domains with other vertebrates except primates, and share some conserved motifs in CRD among all the vertebrates which play a crucial role in interacting with Ca(2+) and for recognizing mannose-containing motifs. In this study, we analyzed genomic organizations, gene structures, and synteny, evolutionary process and expression of miiuy croaker DC-SIGN (mmDC-SIGN) and L-SIGN (mmL-SIGN). Among these fish genomes, genes from TTC8 to ENTPD5 located downstream of L-SIGN had conserved synteny only differing in no RABEPK gene in miiuy croaker and no RABEPK and ALDH6A1 in stickleback. Another phylogenetic tree of L-SIGN genes constructed by Bayesian approach (Fig. 2C ) was used to test the positive selection in ancestral lineages of fishes.	./cache/cord-267234-waz0k0ms.txt	./txt/cord-267234-waz0k0ms.txt