id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279343-ybncwweg	Snyder, Greg A.	The Structure of DC-SIGNR with a Portion of its Repeat Domain Lends Insights to Modeling of the Receptor Tetramer	2005-04-15		.txt	text/plain	5233	258	50	The dendritic cell-specific ICAM-3 non-integrin (DC-SIGN) and its close relative DC-SIGNR recognize various glycoproteins, both pathogenic and cellular, through the receptor lectin domain-mediated carbohydrate recognition. On the basis of the current crystal structure and other published structures with sequence homology to the repeat domain, we generated a tetramer model for DC-SIGN/R using homology modeling and propose a ligand-recognition index to identify potential receptor ligands. [23] [24] [25] Modeling of the DC-SIGN/R tetramer A homology search was performed using sequences corresponding to various lengths of the repeat domain of DC-SIGNR against known structures in the Protein Data Bank (PDB). 21 On the basis of the current crystal structures and available biophysical data, a tetramer for the entire extracellular DC-SIGNR receptor was constructed by homology modeling in which the repeat regions form helical bundles to bring together their CRDs in a 4-fold related symmetry.	./cache/cord-279343-ybncwweg.txt	./txt/cord-279343-ybncwweg.txt