id	sid	tid	token	lemma	pos
cord-279343-ybncwweg	1	1	key	key	NN
cord-279343-ybncwweg	1	2	:	:	:
cord-279343-ybncwweg	2	1	cord-279343-ybncwweg	cord-279343-ybncwweg	NNP
cord-279343-ybncwweg	3	1	authors	author	NNS
cord-279343-ybncwweg	3	2	:	:	:
cord-279343-ybncwweg	3	3	Snyder	Snyder	NNP
cord-279343-ybncwweg	3	4	,	,	,
cord-279343-ybncwweg	3	5	Greg	Greg	NNP
cord-279343-ybncwweg	3	6	A.	A.	NNP
cord-279343-ybncwweg	3	7	;	;	:
cord-279343-ybncwweg	3	8	Colonna	Colonna	NNP
cord-279343-ybncwweg	3	9	,	,	,
cord-279343-ybncwweg	3	10	Marco	Marco	NNP
cord-279343-ybncwweg	3	11	;	;	:
cord-279343-ybncwweg	3	12	Sun	Sun	NNP
cord-279343-ybncwweg	3	13	,	,	,
cord-279343-ybncwweg	3	14	Peter	Peter	NNP
cord-279343-ybncwweg	3	15	D.	D.	NNP
cord-279343-ybncwweg	3	16	title	title	NN
cord-279343-ybncwweg	3	17	:	:	:
cord-279343-ybncwweg	3	18	The	the	DT
cord-279343-ybncwweg	3	19	Structure	Structure	NNP
cord-279343-ybncwweg	3	20	of	of	IN
cord-279343-ybncwweg	3	21	DC	DC	NNP
cord-279343-ybncwweg	3	22	-	-	HYPH
cord-279343-ybncwweg	3	23	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	3	24	with	with	IN
cord-279343-ybncwweg	3	25	a	a	DT
cord-279343-ybncwweg	3	26	Portion	portion	NN
cord-279343-ybncwweg	3	27	of	of	IN
cord-279343-ybncwweg	3	28	its	-PRON-	PRP$
cord-279343-ybncwweg	3	29	Repeat	repeat	NN
cord-279343-ybncwweg	3	30	Domain	Domain	NNP
cord-279343-ybncwweg	3	31	Lends	lend	VBZ
cord-279343-ybncwweg	3	32	Insights	insight	NNS
cord-279343-ybncwweg	3	33	to	to	IN
cord-279343-ybncwweg	3	34	Modeling	Modeling	NNP
cord-279343-ybncwweg	3	35	of	of	IN
cord-279343-ybncwweg	3	36	the	the	DT
cord-279343-ybncwweg	3	37	Receptor	Receptor	NNP
cord-279343-ybncwweg	3	38	Tetramer	Tetramer	NNP
cord-279343-ybncwweg	3	39	date	date	NN
cord-279343-ybncwweg	3	40	:	:	:
cord-279343-ybncwweg	4	1	2005	2005	CD
cord-279343-ybncwweg	4	2	-	-	HYPH
cord-279343-ybncwweg	4	3	04	04	CD
cord-279343-ybncwweg	4	4	-	-	SYM
cord-279343-ybncwweg	4	5	15	15	CD
cord-279343-ybncwweg	4	6	journal	journal	NN
cord-279343-ybncwweg	4	7	:	:	:
cord-279343-ybncwweg	4	8	Journal	Journal	NNP
cord-279343-ybncwweg	4	9	of	of	IN
cord-279343-ybncwweg	4	10	Molecular	Molecular	NNP
cord-279343-ybncwweg	4	11	Biology	Biology	NNP
cord-279343-ybncwweg	4	12	DOI	DOI	NNP
cord-279343-ybncwweg	4	13	:	:	:
cord-279343-ybncwweg	4	14	10.1016	10.1016	CD
cord-279343-ybncwweg	4	15	/	/	SYM
cord-279343-ybncwweg	4	16	j.jmb.2005.01.063	j.jmb.2005.01.063	NN
cord-279343-ybncwweg	4	17	sha	sha	NNP
cord-279343-ybncwweg	4	18	:	:	:
cord-279343-ybncwweg	5	1	dcb38c5a45b930e30d1ea7da83975a63fd0b5cb3	dcb38c5a45b930e30d1ea7da83975a63fd0b5cb3	NNP
cord-279343-ybncwweg	5	2	doc_id	doc_id	CD
cord-279343-ybncwweg	5	3	:	:	:
cord-279343-ybncwweg	6	1	279343	279343	CD
cord-279343-ybncwweg	6	2	cord_uid	cord_uid	NNS
cord-279343-ybncwweg	6	3	:	:	:
cord-279343-ybncwweg	7	1	ybncwweg	ybncwweg	NNP
cord-279343-ybncwweg	7	2	The	the	DT
cord-279343-ybncwweg	7	3	dendritic	dendritic	JJ
cord-279343-ybncwweg	7	4	cell	cell	NN
cord-279343-ybncwweg	7	5	-	-	HYPH
cord-279343-ybncwweg	7	6	specific	specific	JJ
cord-279343-ybncwweg	7	7	ICAM-3	icam-3	JJ
cord-279343-ybncwweg	7	8	non	non	JJ
cord-279343-ybncwweg	7	9	-	-	JJ
cord-279343-ybncwweg	7	10	integrin	integrin	JJ
cord-279343-ybncwweg	7	11	(	(	-LRB-
cord-279343-ybncwweg	7	12	DC	DC	NNP
cord-279343-ybncwweg	7	13	-	-	HYPH
cord-279343-ybncwweg	7	14	SIGN	SIGN	NNP
cord-279343-ybncwweg	7	15	)	)	-RRB-
cord-279343-ybncwweg	7	16	and	and	CC
cord-279343-ybncwweg	8	1	its	-PRON-	PRP$
cord-279343-ybncwweg	8	2	close	close	JJ
cord-279343-ybncwweg	8	3	relative	relative	JJ
cord-279343-ybncwweg	8	4	DC	DC	NNP
cord-279343-ybncwweg	8	5	-	-	HYPH
cord-279343-ybncwweg	8	6	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	8	7	recognize	recognize	VBP
cord-279343-ybncwweg	8	8	various	various	JJ
cord-279343-ybncwweg	8	9	glycoproteins	glycoprotein	NNS
cord-279343-ybncwweg	8	10	,	,	,
cord-279343-ybncwweg	8	11	both	both	CC
cord-279343-ybncwweg	8	12	pathogenic	pathogenic	JJ
cord-279343-ybncwweg	8	13	and	and	CC
cord-279343-ybncwweg	8	14	cellular	cellular	JJ
cord-279343-ybncwweg	8	15	,	,	,
cord-279343-ybncwweg	8	16	through	through	IN
cord-279343-ybncwweg	8	17	the	the	DT
cord-279343-ybncwweg	8	18	receptor	receptor	NN
cord-279343-ybncwweg	8	19	lectin	lectin	NN
cord-279343-ybncwweg	8	20	domain	domain	NN
cord-279343-ybncwweg	8	21	-	-	HYPH
cord-279343-ybncwweg	8	22	mediated	mediate	VBN
cord-279343-ybncwweg	8	23	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	8	24	recognition	recognition	NN
cord-279343-ybncwweg	8	25	.	.	.
cord-279343-ybncwweg	9	1	While	while	IN
cord-279343-ybncwweg	9	2	the	the	DT
cord-279343-ybncwweg	9	3	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	9	4	-	-	HYPH
cord-279343-ybncwweg	9	5	recognition	recognition	NN
cord-279343-ybncwweg	9	6	domains	domain	NNS
cord-279343-ybncwweg	9	7	(	(	-LRB-
cord-279343-ybncwweg	9	8	CRD	CRD	NNP
cord-279343-ybncwweg	9	9	)	)	-RRB-
cord-279343-ybncwweg	9	10	exist	exist	VBP
cord-279343-ybncwweg	9	11	as	as	IN
cord-279343-ybncwweg	9	12	monomers	monomer	NNS
cord-279343-ybncwweg	9	13	and	and	CC
cord-279343-ybncwweg	9	14	bind	bind	VB
cord-279343-ybncwweg	9	15	individual	individual	JJ
cord-279343-ybncwweg	9	16	carbohydrates	carbohydrate	NNS
cord-279343-ybncwweg	9	17	with	with	IN
cord-279343-ybncwweg	9	18	low	low	JJ
cord-279343-ybncwweg	9	19	affinity	affinity	NN
cord-279343-ybncwweg	9	20	and	and	CC
cord-279343-ybncwweg	9	21	are	be	VBP
cord-279343-ybncwweg	9	22	permissive	permissive	JJ
cord-279343-ybncwweg	9	23	in	in	IN
cord-279343-ybncwweg	9	24	nature	nature	NN
cord-279343-ybncwweg	9	25	,	,	,
cord-279343-ybncwweg	9	26	the	the	DT
cord-279343-ybncwweg	9	27	full	full	JJ
cord-279343-ybncwweg	9	28	-	-	HYPH
cord-279343-ybncwweg	9	29	length	length	NN
cord-279343-ybncwweg	9	30	receptors	receptor	NNS
cord-279343-ybncwweg	9	31	form	form	VBP
cord-279343-ybncwweg	9	32	tetramers	tetramer	NNS
cord-279343-ybncwweg	9	33	through	through	IN
cord-279343-ybncwweg	9	34	their	-PRON-	PRP$
cord-279343-ybncwweg	9	35	repeat	repeat	NN
cord-279343-ybncwweg	9	36	domain	domain	NN
cord-279343-ybncwweg	9	37	and	and	CC
cord-279343-ybncwweg	9	38	recognize	recognize	VB
cord-279343-ybncwweg	9	39	specific	specific	JJ
cord-279343-ybncwweg	9	40	ligands	ligand	NNS
cord-279343-ybncwweg	9	41	with	with	IN
cord-279343-ybncwweg	9	42	high	high	JJ
cord-279343-ybncwweg	9	43	affinity	affinity	NN
cord-279343-ybncwweg	9	44	.	.	.
cord-279343-ybncwweg	10	1	To	to	TO
cord-279343-ybncwweg	10	2	understand	understand	VB
cord-279343-ybncwweg	10	3	the	the	DT
cord-279343-ybncwweg	10	4	tetramer	tetramer	NN
cord-279343-ybncwweg	10	5	-	-	HYPH
cord-279343-ybncwweg	10	6	based	base	VBN
cord-279343-ybncwweg	10	7	ligand	ligand	NN
cord-279343-ybncwweg	10	8	binding	bind	VBG
cord-279343-ybncwweg	10	9	avidity	avidity	NN
cord-279343-ybncwweg	10	10	,	,	,
cord-279343-ybncwweg	10	11	we	-PRON-	PRP
cord-279343-ybncwweg	10	12	determined	determine	VBD
cord-279343-ybncwweg	10	13	the	the	DT
cord-279343-ybncwweg	10	14	crystal	crystal	NN
cord-279343-ybncwweg	10	15	structure	structure	NN
cord-279343-ybncwweg	10	16	of	of	IN
cord-279343-ybncwweg	10	17	DC	DC	NNP
cord-279343-ybncwweg	10	18	-	-	HYPH
cord-279343-ybncwweg	10	19	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	10	20	with	with	IN
cord-279343-ybncwweg	10	21	its	-PRON-	PRP$
cord-279343-ybncwweg	10	22	last	last	JJ
cord-279343-ybncwweg	10	23	repeat	repeat	NN
cord-279343-ybncwweg	10	24	region	region	NN
cord-279343-ybncwweg	10	25	.	.	.
cord-279343-ybncwweg	11	1	Compared	compare	VBN
cord-279343-ybncwweg	11	2	to	to	IN
cord-279343-ybncwweg	11	3	the	the	DT
cord-279343-ybncwweg	11	4	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	11	5	-	-	HYPH
cord-279343-ybncwweg	11	6	bound	bind	VBN
cord-279343-ybncwweg	11	7	CRD	crd	NN
cord-279343-ybncwweg	11	8	structure	structure	NN
cord-279343-ybncwweg	11	9	,	,	,
cord-279343-ybncwweg	11	10	the	the	DT
cord-279343-ybncwweg	11	11	structure	structure	NN
cord-279343-ybncwweg	11	12	revealed	reveal	VBD
cord-279343-ybncwweg	11	13	conformational	conformational	JJ
cord-279343-ybncwweg	11	14	changes	change	NNS
cord-279343-ybncwweg	11	15	in	in	IN
cord-279343-ybncwweg	11	16	the	the	DT
cord-279343-ybncwweg	11	17	calcium	calcium	NN
cord-279343-ybncwweg	11	18	and	and	CC
cord-279343-ybncwweg	11	19	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	11	20	coordination	coordination	NN
cord-279343-ybncwweg	11	21	loops	loop	NNS
cord-279343-ybncwweg	11	22	of	of	IN
cord-279343-ybncwweg	11	23	CRD	CRD	NNP
cord-279343-ybncwweg	11	24	,	,	,
cord-279343-ybncwweg	11	25	an	an	DT
cord-279343-ybncwweg	11	26	additional	additional	JJ
cord-279343-ybncwweg	11	27	disulfide	disulfide	JJ
cord-279343-ybncwweg	11	28	bond	bond	NN
cord-279343-ybncwweg	11	29	between	between	IN
cord-279343-ybncwweg	11	30	the	the	DT
cord-279343-ybncwweg	11	31	N	N	NNP
cord-279343-ybncwweg	11	32	and	and	CC
cord-279343-ybncwweg	11	33	the	the	DT
cord-279343-ybncwweg	11	34	C	C	NNP
cord-279343-ybncwweg	11	35	termini	termini	NNPS
cord-279343-ybncwweg	11	36	of	of	IN
cord-279343-ybncwweg	11	37	the	the	DT
cord-279343-ybncwweg	11	38	CRD	crd	NN
cord-279343-ybncwweg	11	39	,	,	,
cord-279343-ybncwweg	11	40	and	and	CC
cord-279343-ybncwweg	11	41	a	a	DT
cord-279343-ybncwweg	11	42	helical	helical	JJ
cord-279343-ybncwweg	11	43	conformation	conformation	NN
cord-279343-ybncwweg	11	44	for	for	IN
cord-279343-ybncwweg	11	45	the	the	DT
cord-279343-ybncwweg	11	46	last	last	JJ
cord-279343-ybncwweg	11	47	repeat	repeat	NN
cord-279343-ybncwweg	11	48	.	.	.
cord-279343-ybncwweg	12	1	On	on	IN
cord-279343-ybncwweg	12	2	the	the	DT
cord-279343-ybncwweg	12	3	basis	basis	NN
cord-279343-ybncwweg	12	4	of	of	IN
cord-279343-ybncwweg	12	5	the	the	DT
cord-279343-ybncwweg	12	6	current	current	JJ
cord-279343-ybncwweg	12	7	crystal	crystal	NN
cord-279343-ybncwweg	12	8	structure	structure	NN
cord-279343-ybncwweg	12	9	and	and	CC
cord-279343-ybncwweg	12	10	other	other	JJ
cord-279343-ybncwweg	12	11	published	publish	VBN
cord-279343-ybncwweg	12	12	structures	structure	NNS
cord-279343-ybncwweg	12	13	with	with	IN
cord-279343-ybncwweg	12	14	sequence	sequence	NN
cord-279343-ybncwweg	12	15	homology	homology	NN
cord-279343-ybncwweg	12	16	to	to	IN
cord-279343-ybncwweg	12	17	the	the	DT
cord-279343-ybncwweg	12	18	repeat	repeat	NN
cord-279343-ybncwweg	12	19	domain	domain	NN
cord-279343-ybncwweg	12	20	,	,	,
cord-279343-ybncwweg	12	21	we	-PRON-	PRP
cord-279343-ybncwweg	12	22	generated	generate	VBD
cord-279343-ybncwweg	12	23	a	a	DT
cord-279343-ybncwweg	12	24	tetramer	tetramer	NN
cord-279343-ybncwweg	12	25	model	model	NN
cord-279343-ybncwweg	12	26	for	for	IN
cord-279343-ybncwweg	12	27	DC	DC	NNP
cord-279343-ybncwweg	12	28	-	-	HYPH
cord-279343-ybncwweg	12	29	SIGN	SIGN	NNP
cord-279343-ybncwweg	12	30	/	/	SYM
cord-279343-ybncwweg	12	31	R	r	NN
cord-279343-ybncwweg	12	32	using	use	VBG
cord-279343-ybncwweg	12	33	homology	homology	NN
cord-279343-ybncwweg	12	34	modeling	modeling	NN
cord-279343-ybncwweg	12	35	and	and	CC
cord-279343-ybncwweg	12	36	propose	propose	VB
cord-279343-ybncwweg	12	37	a	a	DT
cord-279343-ybncwweg	12	38	ligand	ligand	NN
cord-279343-ybncwweg	12	39	-	-	HYPH
cord-279343-ybncwweg	12	40	recognition	recognition	NN
cord-279343-ybncwweg	12	41	index	index	NN
cord-279343-ybncwweg	12	42	to	to	TO
cord-279343-ybncwweg	12	43	identify	identify	VB
cord-279343-ybncwweg	12	44	potential	potential	JJ
cord-279343-ybncwweg	12	45	receptor	receptor	NN
cord-279343-ybncwweg	12	46	ligands	ligand	NNS
cord-279343-ybncwweg	12	47	.	.	.
cord-279343-ybncwweg	13	1	The	the	DT
cord-279343-ybncwweg	13	2	Structure	Structure	NNP
cord-279343-ybncwweg	13	3	of	of	IN
cord-279343-ybncwweg	13	4	DC	DC	NNP
cord-279343-ybncwweg	13	5	-	-	HYPH
cord-279343-ybncwweg	13	6	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	13	7	with	with	IN
cord-279343-ybncwweg	13	8	a	a	DT
cord-279343-ybncwweg	13	9	Portion	portion	NN
cord-279343-ybncwweg	13	10	of	of	IN
cord-279343-ybncwweg	13	11	its	-PRON-	PRP$
cord-279343-ybncwweg	13	12	Repeat	repeat	NN
cord-279343-ybncwweg	13	13	Domain	Domain	NNP
cord-279343-ybncwweg	13	14	Lends	lend	VBZ
cord-279343-ybncwweg	13	15	Insights	insight	NNS
cord-279343-ybncwweg	13	16	to	to	IN
cord-279343-ybncwweg	13	17	Modeling	Modeling	NNP
cord-279343-ybncwweg	13	18	of	of	IN
cord-279343-ybncwweg	13	19	the	the	DT
cord-279343-ybncwweg	13	20	Receptor	Receptor	NNP
cord-279343-ybncwweg	13	21	Tetramer	Tetramer	NNP
cord-279343-ybncwweg	13	22	Greg	Greg	NNP
cord-279343-ybncwweg	13	23	A.	a.	NN
cord-279343-ybncwweg	13	24	Snyder	Snyder	NNP
cord-279343-ybncwweg	13	25	1,3	1,3	CD
cord-279343-ybncwweg	13	26	,	,	,
cord-279343-ybncwweg	13	27	Marco	Marco	NNP
cord-279343-ybncwweg	13	28	Colonna	Colonna	NNP
cord-279343-ybncwweg	13	29	2	2	CD
cord-279343-ybncwweg	13	30	and	and	CC
cord-279343-ybncwweg	13	31	Peter	Peter	NNP
cord-279343-ybncwweg	13	32	D.	D.	NNP
cord-279343-ybncwweg	13	33	Sun	Sun	NNP
cord-279343-ybncwweg	13	34	1	1	CD
cord-279343-ybncwweg	14	1	*	*	NFP
cord-279343-ybncwweg	14	2	Introduction	Introduction	NNP
cord-279343-ybncwweg	14	3	The	the	DT
cord-279343-ybncwweg	14	4	dendritic	dendritic	JJ
cord-279343-ybncwweg	14	5	cell	cell	NN
cord-279343-ybncwweg	14	6	-	-	HYPH
cord-279343-ybncwweg	14	7	specific	specific	JJ
cord-279343-ybncwweg	14	8	ICAM-3	icam-3	JJ
cord-279343-ybncwweg	14	9	non	non	JJ
cord-279343-ybncwweg	14	10	-	-	JJ
cord-279343-ybncwweg	14	11	integrin	integrin	JJ
cord-279343-ybncwweg	14	12	(	(	-LRB-
cord-279343-ybncwweg	14	13	DC	DC	NNP
cord-279343-ybncwweg	14	14	-	-	HYPH
cord-279343-ybncwweg	14	15	SIGN	SIGN	NNP
cord-279343-ybncwweg	14	16	)	)	-RRB-
cord-279343-ybncwweg	14	17	and	and	CC
cord-279343-ybncwweg	14	18	its	-PRON-	PRP$
cord-279343-ybncwweg	14	19	close	close	JJ
cord-279343-ybncwweg	14	20	relative	relative	JJ
cord-279343-ybncwweg	14	21	DC	DC	NNP
cord-279343-ybncwweg	14	22	-	-	HYPH
cord-279343-ybncwweg	14	23	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	14	24	are	be	VBP
cord-279343-ybncwweg	14	25	members	member	NNS
cord-279343-ybncwweg	14	26	of	of	IN
cord-279343-ybncwweg	14	27	the	the	DT
cord-279343-ybncwweg	14	28	C	c	NN
cord-279343-ybncwweg	14	29	-	-	HYPH
cord-279343-ybncwweg	14	30	type	type	NN
cord-279343-ybncwweg	14	31	lectin	lectin	NN
cord-279343-ybncwweg	14	32	family	family	NN
cord-279343-ybncwweg	14	33	.	.	.
cord-279343-ybncwweg	15	1	Originally	originally	RB
cord-279343-ybncwweg	15	2	discovered	discover	VBN
cord-279343-ybncwweg	15	3	as	as	IN
cord-279343-ybncwweg	15	4	a	a	DT
cord-279343-ybncwweg	15	5	human	human	JJ
cord-279343-ybncwweg	15	6	immunodeficiency	immunodeficiency	NN
cord-279343-ybncwweg	15	7	virus	virus	NN
cord-279343-ybncwweg	15	8	(	(	-LRB-
cord-279343-ybncwweg	15	9	HIV)-binding	hiv)-binde	VBG
cord-279343-ybncwweg	15	10	protein	protein	NN
cord-279343-ybncwweg	15	11	,	,	,
cord-279343-ybncwweg	15	12	DC	DC	NNP
cord-279343-ybncwweg	15	13	-	-	HYPH
cord-279343-ybncwweg	15	14	SIGN	SIGN	NNP
cord-279343-ybncwweg	15	15	has	have	VBZ
cord-279343-ybncwweg	15	16	been	be	VBN
cord-279343-ybncwweg	15	17	shown	show	VBN
cord-279343-ybncwweg	15	18	to	to	TO
cord-279343-ybncwweg	15	19	bind	bind	VB
cord-279343-ybncwweg	15	20	carbohydrates	carbohydrate	NNS
cord-279343-ybncwweg	15	21	on	on	IN
cord-279343-ybncwweg	15	22	various	various	JJ
cord-279343-ybncwweg	15	23	pathogens	pathogen	NNS
cord-279343-ybncwweg	15	24	,	,	,
cord-279343-ybncwweg	15	25	including	include	VBG
cord-279343-ybncwweg	15	26	Ebola	Ebola	NNP
cord-279343-ybncwweg	15	27	,	,	,
cord-279343-ybncwweg	15	28	Mycobacterium	Mycobacterium	NNP
cord-279343-ybncwweg	15	29	tuberculosis	tuberculosis	NN
cord-279343-ybncwweg	15	30	,	,	,
cord-279343-ybncwweg	15	31	hepatitis	hepatitis	NN
cord-279343-ybncwweg	15	32	C	C	NNP
cord-279343-ybncwweg	15	33	virus	virus	NN
cord-279343-ybncwweg	15	34	and	and	CC
cord-279343-ybncwweg	15	35	cytomegalovirus	cytomegalovirus	NN
cord-279343-ybncwweg	15	36	.	.	.
cord-279343-ybncwweg	16	1	[	[	-LRB-
cord-279343-ybncwweg	16	2	1	1	CD
cord-279343-ybncwweg	16	3	]	]	-RRB-
cord-279343-ybncwweg	16	4	[	[	-LRB-
cord-279343-ybncwweg	16	5	2	2	CD
cord-279343-ybncwweg	16	6	]	]	-RRB-
cord-279343-ybncwweg	16	7	[	[	-LRB-
cord-279343-ybncwweg	16	8	3	3	CD
cord-279343-ybncwweg	16	9	]	]	-RRB-
cord-279343-ybncwweg	16	10	[	[	-LRB-
cord-279343-ybncwweg	16	11	4	4	CD
cord-279343-ybncwweg	16	12	]	]	-RRB-
cord-279343-ybncwweg	16	13	[	[	-LRB-
cord-279343-ybncwweg	16	14	5	5	CD
cord-279343-ybncwweg	16	15	]	]	-RRB-
cord-279343-ybncwweg	16	16	[	[	-LRB-
cord-279343-ybncwweg	16	17	6	6	CD
cord-279343-ybncwweg	16	18	]	]	-RRB-
cord-279343-ybncwweg	16	19	[	[	-LRB-
cord-279343-ybncwweg	16	20	7	7	CD
cord-279343-ybncwweg	16	21	]	]	-RRB-
cord-279343-ybncwweg	17	1	[	[	-LRB-
cord-279343-ybncwweg	17	2	8	8	CD
cord-279343-ybncwweg	17	3	]	]	-RRB-
cord-279343-ybncwweg	17	4	[	[	-LRB-
cord-279343-ybncwweg	17	5	9	9	CD
cord-279343-ybncwweg	17	6	]	]	-RRB-
cord-279343-ybncwweg	17	7	[	[	-LRB-
cord-279343-ybncwweg	17	8	10	10	CD
cord-279343-ybncwweg	17	9	]	]	-RRB-
cord-279343-ybncwweg	17	10	[	[	-LRB-
cord-279343-ybncwweg	17	11	11	11	CD
cord-279343-ybncwweg	17	12	]	]	-RRB-
cord-279343-ybncwweg	18	1	In	in	IN
cord-279343-ybncwweg	18	2	the	the	DT
cord-279343-ybncwweg	18	3	case	case	NN
cord-279343-ybncwweg	18	4	of	of	IN
cord-279343-ybncwweg	18	5	HIV-1	HIV-1	NNP
cord-279343-ybncwweg	18	6	infection	infection	NN
cord-279343-ybncwweg	18	7	,	,	,
cord-279343-ybncwweg	18	8	DC	DC	NNP
cord-279343-ybncwweg	18	9	-	-	HYPH
cord-279343-ybncwweg	18	10	SIGN	SIGN	NNP
cord-279343-ybncwweg	18	11	and	and	CC
cord-279343-ybncwweg	18	12	DC	DC	NNP
cord-279343-ybncwweg	18	13	-	-	HYPH
cord-279343-ybncwweg	18	14	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	18	15	(	(	-LRB-
cord-279343-ybncwweg	18	16	together	together	RB
cord-279343-ybncwweg	18	17	referred	refer	VBN
cord-279343-ybncwweg	18	18	to	to	IN
cord-279343-ybncwweg	18	19	as	as	IN
cord-279343-ybncwweg	18	20	DC	DC	NNP
cord-279343-ybncwweg	18	21	-	-	HYPH
cord-279343-ybncwweg	18	22	SIGN	sign	NN
cord-279343-ybncwweg	18	23	/	/	SYM
cord-279343-ybncwweg	18	24	R	r	NN
cord-279343-ybncwweg	18	25	)	)	-RRB-
cord-279343-ybncwweg	18	26	have	have	VBP
cord-279343-ybncwweg	18	27	been	be	VBN
cord-279343-ybncwweg	18	28	proposed	propose	VBN
cord-279343-ybncwweg	18	29	to	to	TO
cord-279343-ybncwweg	18	30	facilitate	facilitate	VB
cord-279343-ybncwweg	18	31	the	the	DT
cord-279343-ybncwweg	18	32	viral	viral	JJ
cord-279343-ybncwweg	18	33	infection	infection	NN
cord-279343-ybncwweg	18	34	of	of	IN
cord-279343-ybncwweg	18	35	T	t	NN
cord-279343-ybncwweg	18	36	-	-	HYPH
cord-279343-ybncwweg	18	37	cells	cell	NNS
cord-279343-ybncwweg	18	38	in	in	IN
cord-279343-ybncwweg	18	39	trans	trans	NNP
cord-279343-ybncwweg	18	40	through	through	IN
cord-279343-ybncwweg	18	41	binding	bind	VBG
cord-279343-ybncwweg	18	42	with	with	IN
cord-279343-ybncwweg	18	43	HIV	HIV	NNP
cord-279343-ybncwweg	18	44	gp120	gp120	NNP
cord-279343-ybncwweg	18	45	.	.	.
cord-279343-ybncwweg	19	1	5	5	CD
cord-279343-ybncwweg	19	2	,	,	,
cord-279343-ybncwweg	19	3	12	12	CD
cord-279343-ybncwweg	20	1	However	however	RB
cord-279343-ybncwweg	20	2	,	,	,
cord-279343-ybncwweg	20	3	recent	recent	JJ
cord-279343-ybncwweg	20	4	evidence	evidence	NN
cord-279343-ybncwweg	20	5	suggests	suggest	VBZ
cord-279343-ybncwweg	20	6	that	that	IN
cord-279343-ybncwweg	20	7	DC	DC	NNP
cord-279343-ybncwweg	20	8	-	-	HYPH
cord-279343-ybncwweg	20	9	SIGN	SIGN	NNP
cord-279343-ybncwweg	20	10	/	/	SYM
cord-279343-ybncwweg	20	11	R	r	NN
cord-279343-ybncwweg	20	12	function	function	NN
cord-279343-ybncwweg	20	13	as	as	IN
cord-279343-ybncwweg	20	14	antigen	antigen	NN
cord-279343-ybncwweg	20	15	capturing	capture	VBG
cord-279343-ybncwweg	20	16	receptors	receptor	NNS
cord-279343-ybncwweg	20	17	to	to	TO
cord-279343-ybncwweg	20	18	facilitate	facilitate	VB
cord-279343-ybncwweg	20	19	the	the	DT
cord-279343-ybncwweg	20	20	presentation	presentation	NN
cord-279343-ybncwweg	20	21	of	of	IN
cord-279343-ybncwweg	20	22	HIV-1	HIV-1	NNP
cord-279343-ybncwweg	20	23	antigen	antigen	NN
cord-279343-ybncwweg	20	24	by	by	IN
cord-279343-ybncwweg	20	25	dendritic	dendritic	JJ
cord-279343-ybncwweg	20	26	cells	cell	NNS
cord-279343-ybncwweg	20	27	.	.	.
cord-279343-ybncwweg	21	1	13	13	CD
cord-279343-ybncwweg	21	2	DC	DC	NNP
cord-279343-ybncwweg	21	3	-	-	HYPH
cord-279343-ybncwweg	21	4	SIGN	sign	NN
cord-279343-ybncwweg	21	5	/	/	SYM
cord-279343-ybncwweg	21	6	R	r	NN
cord-279343-ybncwweg	21	7	each	each	DT
cord-279343-ybncwweg	21	8	consist	consist	VBP
cord-279343-ybncwweg	21	9	of	of	IN
cord-279343-ybncwweg	21	10	four	four	CD
cord-279343-ybncwweg	21	11	domains	domain	NNS
cord-279343-ybncwweg	21	12	:	:	:
cord-279343-ybncwweg	21	13	a	a	DT
cord-279343-ybncwweg	21	14	cytoplasmic	cytoplasmic	JJ
cord-279343-ybncwweg	21	15	domain	domain	NN
cord-279343-ybncwweg	21	16	with	with	IN
cord-279343-ybncwweg	21	17	a	a	DT
cord-279343-ybncwweg	21	18	di	di	NN
cord-279343-ybncwweg	21	19	-	-	HYPH
cord-279343-ybncwweg	21	20	leucine	leucine	JJ
cord-279343-ybncwweg	21	21	motif	motif	NN
cord-279343-ybncwweg	21	22	for	for	IN
cord-279343-ybncwweg	21	23	internalization	internalization	NN
cord-279343-ybncwweg	21	24	,	,	,
cord-279343-ybncwweg	21	25	a	a	DT
cord-279343-ybncwweg	21	26	single	single	RB
cord-279343-ybncwweg	21	27	-	-	HYPH
cord-279343-ybncwweg	21	28	spanning	span	VBG
cord-279343-ybncwweg	21	29	transmembrane	transmembrane	NN
cord-279343-ybncwweg	21	30	region	region	NN
cord-279343-ybncwweg	21	31	,	,	,
cord-279343-ybncwweg	21	32	a	a	DT
cord-279343-ybncwweg	21	33	region	region	NN
cord-279343-ybncwweg	21	34	with	with	IN
cord-279343-ybncwweg	21	35	seven	seven	CD
cord-279343-ybncwweg	21	36	and	and	CC
cord-279343-ybncwweg	21	37	one	one	CD
cord-279343-ybncwweg	21	38	-	-	HYPH
cord-279343-ybncwweg	21	39	half	half	NN
cord-279343-ybncwweg	21	40	23	23	CD
cord-279343-ybncwweg	21	41	amino	amino	NN
cord-279343-ybncwweg	21	42	acid	acid	NN
cord-279343-ybncwweg	21	43	residue	residue	NN
cord-279343-ybncwweg	21	44	repeats	repeat	VBZ
cord-279343-ybncwweg	21	45	,	,	,
cord-279343-ybncwweg	21	46	and	and	CC
cord-279343-ybncwweg	21	47	a	a	DT
cord-279343-ybncwweg	21	48	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	21	49	-	-	HYPH
cord-279343-ybncwweg	21	50	recognition	recognition	NN
cord-279343-ybncwweg	21	51	domain	domain	NN
cord-279343-ybncwweg	21	52	(	(	-LRB-
cord-279343-ybncwweg	21	53	CRD	CRD	NNP
cord-279343-ybncwweg	21	54	)	)	-RRB-
cord-279343-ybncwweg	21	55	.	.	.
cord-279343-ybncwweg	22	1	DC	DC	NNP
cord-279343-ybncwweg	22	2	-	-	HYPH
cord-279343-ybncwweg	22	3	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	22	4	is	be	VBZ
cord-279343-ybncwweg	22	5	77	77	CD
cord-279343-ybncwweg	22	6	%	%	NN
cord-279343-ybncwweg	22	7	identical	identical	JJ
cord-279343-ybncwweg	22	8	with	with	IN
cord-279343-ybncwweg	22	9	DC	DC	NNP
cord-279343-ybncwweg	22	10	-	-	HYPH
cord-279343-ybncwweg	22	11	SIGN	sign	NN
cord-279343-ybncwweg	22	12	in	in	IN
cord-279343-ybncwweg	22	13	amino	amino	NN
cord-279343-ybncwweg	22	14	acid	acid	NN
cord-279343-ybncwweg	22	15	sequence	sequence	NN
cord-279343-ybncwweg	22	16	,	,	,
cord-279343-ybncwweg	22	17	and	and	CC
cord-279343-ybncwweg	22	18	differs	differ	VBZ
cord-279343-ybncwweg	22	19	mainly	mainly	RB
cord-279343-ybncwweg	22	20	in	in	IN
cord-279343-ybncwweg	22	21	tissue	tissue	NN
cord-279343-ybncwweg	22	22	and	and	CC
cord-279343-ybncwweg	22	23	cellular	cellular	JJ
cord-279343-ybncwweg	22	24	expression	expression	NN
cord-279343-ybncwweg	22	25	patterns	pattern	NNS
cord-279343-ybncwweg	22	26	although	although	IN
cord-279343-ybncwweg	22	27	recent	recent	JJ
cord-279343-ybncwweg	22	28	reports	report	NNS
cord-279343-ybncwweg	22	29	indicate	indicate	VBP
cord-279343-ybncwweg	22	30	that	that	IN
cord-279343-ybncwweg	22	31	it	-PRON-	PRP
cord-279343-ybncwweg	22	32	may	may	MD
cord-279343-ybncwweg	22	33	differ	differ	VB
cord-279343-ybncwweg	22	34	in	in	IN
cord-279343-ybncwweg	22	35	binding	bind	VBG
cord-279343-ybncwweg	22	36	and	and	CC
cord-279343-ybncwweg	22	37	processing	processing	NN
cord-279343-ybncwweg	22	38	of	of	IN
cord-279343-ybncwweg	22	39	pathogens	pathogen	NNS
cord-279343-ybncwweg	22	40	.	.	.
cord-279343-ybncwweg	23	1	[	[	-LRB-
cord-279343-ybncwweg	23	2	14	14	CD
cord-279343-ybncwweg	23	3	]	]	-RRB-
cord-279343-ybncwweg	23	4	[	[	-LRB-
cord-279343-ybncwweg	23	5	15	15	CD
cord-279343-ybncwweg	23	6	]	]	-RRB-
cord-279343-ybncwweg	24	1	[	[	-LRB-
cord-279343-ybncwweg	24	2	16	16	CD
cord-279343-ybncwweg	24	3	]	]	-RRB-
cord-279343-ybncwweg	25	1	It	-PRON-	PRP
cord-279343-ybncwweg	25	2	has	have	VBZ
cord-279343-ybncwweg	25	3	been	be	VBN
cord-279343-ybncwweg	25	4	established	establish	VBN
cord-279343-ybncwweg	25	5	that	that	IN
cord-279343-ybncwweg	25	6	DC	DC	NNP
cord-279343-ybncwweg	25	7	-	-	HYPH
cord-279343-ybncwweg	25	8	SIGN	SIGN	NNP
cord-279343-ybncwweg	25	9	/	/	SYM
cord-279343-ybncwweg	25	10	R	r	NN
cord-279343-ybncwweg	25	11	recognize	recognize	VBP
cord-279343-ybncwweg	25	12	specifically	specifically	RB
cord-279343-ybncwweg	25	13	high	high	JJ
cord-279343-ybncwweg	25	14	-	-	HYPH
cord-279343-ybncwweg	25	15	mannose	mannose	NN
cord-279343-ybncwweg	25	16	carbohydrates	carbohydrate	NNS
cord-279343-ybncwweg	25	17	.	.	.
cord-279343-ybncwweg	26	1	17	17	CD
cord-279343-ybncwweg	27	1	Previous	previous	JJ
cord-279343-ybncwweg	27	2	structural	structural	JJ
cord-279343-ybncwweg	27	3	studies	study	NNS
cord-279343-ybncwweg	27	4	have	have	VBP
cord-279343-ybncwweg	27	5	shown	show	VBN
cord-279343-ybncwweg	27	6	the	the	DT
cord-279343-ybncwweg	27	7	molecular	molecular	JJ
cord-279343-ybncwweg	27	8	details	detail	NNS
cord-279343-ybncwweg	27	9	of	of	IN
cord-279343-ybncwweg	27	10	this	this	DT
cord-279343-ybncwweg	27	11	interaction	interaction	NN
cord-279343-ybncwweg	27	12	.	.	.
cord-279343-ybncwweg	28	1	18	18	CD
cord-279343-ybncwweg	28	2	More	more	RBR
cord-279343-ybncwweg	28	3	recently	recently	RB
cord-279343-ybncwweg	28	4	,	,	,
cord-279343-ybncwweg	28	5	however	however	RB
cord-279343-ybncwweg	28	6	,	,	,
cord-279343-ybncwweg	28	7	DC	DC	NNP
cord-279343-ybncwweg	28	8	-	-	HYPH
cord-279343-ybncwweg	28	9	SIGN	SIGN	NNP
cord-279343-ybncwweg	28	10	/	/	SYM
cord-279343-ybncwweg	28	11	R	r	NN
cord-279343-ybncwweg	28	12	were	be	VBD
cord-279343-ybncwweg	28	13	shown	show	VBN
cord-279343-ybncwweg	28	14	to	to	TO
cord-279343-ybncwweg	28	15	recognize	recognize	VB
cord-279343-ybncwweg	28	16	terminal	terminal	JJ
cord-279343-ybncwweg	28	17	fucose	fucose	NNS
cord-279343-ybncwweg	28	18	and	and	CC
cord-279343-ybncwweg	28	19	galactose	galactose	NN
cord-279343-ybncwweg	28	20	-	-	HYPH
cord-279343-ybncwweg	28	21	containing	contain	VBG
cord-279343-ybncwweg	28	22	carbohydrates	carbohydrate	NNS
cord-279343-ybncwweg	28	23	,	,	,
cord-279343-ybncwweg	28	24	such	such	JJ
cord-279343-ybncwweg	28	25	as	as	IN
cord-279343-ybncwweg	28	26	blood	blood	NN
cord-279343-ybncwweg	28	27	group	group	NN
cord-279343-ybncwweg	28	28	antigens	antigen	NNS
cord-279343-ybncwweg	28	29	B	B	NNP
cord-279343-ybncwweg	28	30	Lewis	Lewis	NNP
cord-279343-ybncwweg	28	31	a	a	NNP
cord-279343-ybncwweg	28	32	,	,	,
cord-279343-ybncwweg	28	33	and	and	CC
cord-279343-ybncwweg	29	1	Lewis	Lewis	NNP
cord-279343-ybncwweg	29	2	x	x	IN
cord-279343-ybncwweg	29	3	structures	structure	NNS
cord-279343-ybncwweg	29	4	in	in	IN
cord-279343-ybncwweg	29	5	addition	addition	NN
cord-279343-ybncwweg	29	6	to	to	IN
cord-279343-ybncwweg	29	7	mannose	mannose	NN
cord-279343-ybncwweg	29	8	.	.	.
cord-279343-ybncwweg	29	9	18	18	CD
cord-279343-ybncwweg	29	10	,	,	,
cord-279343-ybncwweg	29	11	19	19	CD
cord-279343-ybncwweg	30	1	While	while	IN
cord-279343-ybncwweg	30	2	recognition	recognition	NN
cord-279343-ybncwweg	30	3	between	between	IN
cord-279343-ybncwweg	30	4	various	various	JJ
cord-279343-ybncwweg	30	5	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	30	6	substructures	substructure	NNS
cord-279343-ybncwweg	30	7	gives	give	VBZ
cord-279343-ybncwweg	30	8	insight	insight	NN
cord-279343-ybncwweg	30	9	into	into	IN
cord-279343-ybncwweg	30	10	how	how	WRB
cord-279343-ybncwweg	30	11	various	various	JJ
cord-279343-ybncwweg	30	12	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	30	13	model	model	NN
cord-279343-ybncwweg	30	14	compounds	compound	NNS
cord-279343-ybncwweg	30	15	are	be	VBP
cord-279343-ybncwweg	30	16	recognized	recognize	VBN
cord-279343-ybncwweg	30	17	by	by	IN
cord-279343-ybncwweg	30	18	the	the	DT
cord-279343-ybncwweg	30	19	CRD	crd	NN
cord-279343-ybncwweg	30	20	of	of	IN
cord-279343-ybncwweg	30	21	the	the	DT
cord-279343-ybncwweg	30	22	receptor	receptor	NN
cord-279343-ybncwweg	30	23	,	,	,
cord-279343-ybncwweg	30	24	the	the	DT
cord-279343-ybncwweg	30	25	overall	overall	JJ
cord-279343-ybncwweg	30	26	receptor	receptor	NN
cord-279343-ybncwweg	30	27	binding	bind	VBG
cord-279343-ybncwweg	30	28	affinity	affinity	NN
cord-279343-ybncwweg	30	29	appears	appear	VBZ
cord-279343-ybncwweg	30	30	to	to	TO
cord-279343-ybncwweg	30	31	depend	depend	VB
cord-279343-ybncwweg	30	32	on	on	IN
cord-279343-ybncwweg	30	33	the	the	DT
cord-279343-ybncwweg	30	34	0022	0022	CD
cord-279343-ybncwweg	30	35	E	e	NN
cord-279343-ybncwweg	30	36	-	-	NN
cord-279343-ybncwweg	30	37	mail	mail	JJ
cord-279343-ybncwweg	30	38	address	address	NN
cord-279343-ybncwweg	30	39	of	of	IN
cord-279343-ybncwweg	30	40	the	the	DT
cord-279343-ybncwweg	30	41	corresponding	correspond	VBG
cord-279343-ybncwweg	30	42	author	author	NN
cord-279343-ybncwweg	30	43	:	:	:
cord-279343-ybncwweg	30	44	psun@nih.gov	psun@nih.gov	NNP
cord-279343-ybncwweg	30	45	multivalent	multivalent	JJ
cord-279343-ybncwweg	30	46	nature	nature	NN
cord-279343-ybncwweg	30	47	of	of	IN
cord-279343-ybncwweg	30	48	the	the	DT
cord-279343-ybncwweg	30	49	ligand	ligand	NN
cord-279343-ybncwweg	30	50	.	.	.
cord-279343-ybncwweg	31	1	20	20	CD
cord-279343-ybncwweg	32	1	For	for	IN
cord-279343-ybncwweg	32	2	example	example	NN
cord-279343-ybncwweg	32	3	,	,	,
cord-279343-ybncwweg	32	4	while	while	IN
cord-279343-ybncwweg	32	5	DC	DC	NNP
cord-279343-ybncwweg	32	6	-	-	HYPH
cord-279343-ybncwweg	32	7	SIGN	SIGN	NNP
cord-279343-ybncwweg	32	8	/	/	SYM
cord-279343-ybncwweg	32	9	R	r	NN
cord-279343-ybncwweg	32	10	bind	bind	NN
cord-279343-ybncwweg	32	11	to	to	TO
cord-279343-ybncwweg	32	12	model	model	VB
cord-279343-ybncwweg	32	13	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	32	14	with	with	IN
cord-279343-ybncwweg	32	15	millimolar	millimolar	JJ
cord-279343-ybncwweg	32	16	affinity	affinity	NN
cord-279343-ybncwweg	32	17	,	,	,
cord-279343-ybncwweg	32	18	the	the	DT
cord-279343-ybncwweg	32	19	receptors	receptor	NNS
cord-279343-ybncwweg	32	20	recognize	recognize	VBP
cord-279343-ybncwweg	32	21	HIV	HIV	NNP
cord-279343-ybncwweg	32	22	gp120	gp120	NNP
cord-279343-ybncwweg	32	23	,	,	,
cord-279343-ybncwweg	32	24	which	which	WDT
cord-279343-ybncwweg	32	25	carries	carry	VBZ
cord-279343-ybncwweg	32	26	multiple	multiple	JJ
cord-279343-ybncwweg	32	27	high	high	RB
cord-279343-ybncwweg	32	28	-	-	HYPH
cord-279343-ybncwweg	32	29	mannosebased	mannosebased	JJ
cord-279343-ybncwweg	32	30	,	,	,
cord-279343-ybncwweg	32	31	N	N	NNP
cord-279343-ybncwweg	32	32	-	-	HYPH
cord-279343-ybncwweg	32	33	linked	link	VBN
cord-279343-ybncwweg	32	34	glycosylations	glycosylation	NNS
cord-279343-ybncwweg	32	35	with	with	IN
cord-279343-ybncwweg	32	36	nanomolar	nanomolar	NNP
cord-279343-ybncwweg	32	37	affinity	affinity	NNP
cord-279343-ybncwweg	32	38	.	.	.
cord-279343-ybncwweg	33	1	This	this	DT
cord-279343-ybncwweg	33	2	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	33	3	valency	valency	NN
cord-279343-ybncwweg	33	4	-	-	HYPH
cord-279343-ybncwweg	33	5	dependent	dependent	JJ
cord-279343-ybncwweg	33	6	avidity	avidity	NN
cord-279343-ybncwweg	33	7	effect	effect	NN
cord-279343-ybncwweg	33	8	was	be	VBD
cord-279343-ybncwweg	33	9	shown	show	VBN
cord-279343-ybncwweg	33	10	to	to	TO
cord-279343-ybncwweg	33	11	be	be	VB
cord-279343-ybncwweg	33	12	the	the	DT
cord-279343-ybncwweg	33	13	result	result	NN
cord-279343-ybncwweg	33	14	of	of	IN
cord-279343-ybncwweg	33	15	DC	DC	NNP
cord-279343-ybncwweg	33	16	-	-	HYPH
cord-279343-ybncwweg	33	17	SIGN	SIGN	NNP
cord-279343-ybncwweg	33	18	/	/	SYM
cord-279343-ybncwweg	33	19	R	r	NN
cord-279343-ybncwweg	33	20	tetramerization	tetramerization	NN
cord-279343-ybncwweg	33	21	through	through	IN
cord-279343-ybncwweg	33	22	its	-PRON-	PRP$
cord-279343-ybncwweg	33	23	repeat	repeat	NN
cord-279343-ybncwweg	33	24	region	region	NN
cord-279343-ybncwweg	33	25	.	.	.
cord-279343-ybncwweg	34	1	17	17	CD
cord-279343-ybncwweg	34	2	,	,	,
cord-279343-ybncwweg	34	3	21	21	CD
cord-279343-ybncwweg	35	1	To	to	TO
cord-279343-ybncwweg	35	2	understand	understand	VB
cord-279343-ybncwweg	35	3	the	the	DT
cord-279343-ybncwweg	35	4	nature	nature	NN
cord-279343-ybncwweg	35	5	of	of	IN
cord-279343-ybncwweg	35	6	the	the	DT
cord-279343-ybncwweg	35	7	receptor	receptor	NN
cord-279343-ybncwweg	35	8	-	-	HYPH
cord-279343-ybncwweg	35	9	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	35	10	interaction	interaction	NN
cord-279343-ybncwweg	35	11	,	,	,
cord-279343-ybncwweg	35	12	we	-PRON-	PRP
cord-279343-ybncwweg	35	13	have	have	VBP
cord-279343-ybncwweg	35	14	determined	determine	VBN
cord-279343-ybncwweg	35	15	the	the	DT
cord-279343-ybncwweg	35	16	crystal	crystal	JJ
cord-279343-ybncwweg	35	17	structure	structure	NN
cord-279343-ybncwweg	35	18	of	of	IN
cord-279343-ybncwweg	35	19	DC	DC	NNP
cord-279343-ybncwweg	35	20	-	-	HYPH
cord-279343-ybncwweg	35	21	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	35	22	with	with	IN
cord-279343-ybncwweg	35	23	a	a	DT
cord-279343-ybncwweg	35	24	portion	portion	NN
cord-279343-ybncwweg	35	25	of	of	IN
cord-279343-ybncwweg	35	26	the	the	DT
cord-279343-ybncwweg	35	27	repeat	repeat	NN
cord-279343-ybncwweg	35	28	domain	domain	NN
cord-279343-ybncwweg	35	29	.	.	.
cord-279343-ybncwweg	36	1	We	-PRON-	PRP
cord-279343-ybncwweg	36	2	propose	propose	VBP
cord-279343-ybncwweg	36	3	a	a	DT
cord-279343-ybncwweg	36	4	tetramer	tetramer	NN
cord-279343-ybncwweg	36	5	model	model	NN
cord-279343-ybncwweg	36	6	for	for	IN
cord-279343-ybncwweg	36	7	the	the	DT
cord-279343-ybncwweg	36	8	intact	intact	JJ
cord-279343-ybncwweg	36	9	extracellular	extracellular	JJ
cord-279343-ybncwweg	36	10	receptor	receptor	NN
cord-279343-ybncwweg	36	11	,	,	,
cord-279343-ybncwweg	36	12	and	and	CC
cord-279343-ybncwweg	36	13	formulate	formulate	VB
cord-279343-ybncwweg	36	14	a	a	DT
cord-279343-ybncwweg	36	15	scheme	scheme	NN
cord-279343-ybncwweg	36	16	to	to	TO
cord-279343-ybncwweg	36	17	predict	predict	VB
cord-279343-ybncwweg	36	18	the	the	DT
cord-279343-ybncwweg	36	19	potential	potential	JJ
cord-279343-ybncwweg	36	20	ligands	ligand	NNS
cord-279343-ybncwweg	36	21	.	.	.
cord-279343-ybncwweg	37	1	The	the	DT
cord-279343-ybncwweg	37	2	crystals	crystal	NNS
cord-279343-ybncwweg	37	3	of	of	IN
cord-279343-ybncwweg	37	4	DC	DC	NNP
cord-279343-ybncwweg	37	5	-	-	HYPH
cord-279343-ybncwweg	37	6	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	37	7	CRD	crd	NN
cord-279343-ybncwweg	37	8	with	with	IN
cord-279343-ybncwweg	37	9	its	-PRON-	PRP$
cord-279343-ybncwweg	37	10	last	last	JJ
cord-279343-ybncwweg	37	11	repeat	repeat	NN
cord-279343-ybncwweg	37	12	belong	belong	VBP
cord-279343-ybncwweg	37	13	to	to	IN
cord-279343-ybncwweg	37	14	the	the	DT
cord-279343-ybncwweg	37	15	orthorhombic	orthorhombic	JJ
cord-279343-ybncwweg	37	16	space	space	NN
cord-279343-ybncwweg	37	17	group	group	NN
cord-279343-ybncwweg	37	18	P2	P2	NNP
cord-279343-ybncwweg	37	19	1	1	CD
cord-279343-ybncwweg	37	20	2	2	CD
cord-279343-ybncwweg	37	21	1	1	CD
cord-279343-ybncwweg	37	22	2	2	CD
cord-279343-ybncwweg	37	23	1	1	CD
cord-279343-ybncwweg	37	24	.	.	.
cord-279343-ybncwweg	38	1	The	the	DT
cord-279343-ybncwweg	38	2	protein	protein	NN
cord-279343-ybncwweg	38	3	solution	solution	NN
cord-279343-ybncwweg	38	4	was	be	VBD
cord-279343-ybncwweg	38	5	supplemented	supplement	VBN
cord-279343-ybncwweg	38	6	with	with	IN
cord-279343-ybncwweg	38	7	10	10	CD
cord-279343-ybncwweg	38	8	mM	mm	CD
cord-279343-ybncwweg	38	9	mannose	mannose	NN
cord-279343-ybncwweg	38	10	and	and	CC
cord-279343-ybncwweg	38	11	5	5	CD
cord-279343-ybncwweg	38	12	mM	mm	CD
cord-279343-ybncwweg	38	13	CaCl	cacl	NN
cord-279343-ybncwweg	38	14	2	2	CD
cord-279343-ybncwweg	38	15	prior	prior	RB
cord-279343-ybncwweg	38	16	to	to	IN
cord-279343-ybncwweg	38	17	crystallization	crystallization	NN
cord-279343-ybncwweg	38	18	.	.	.
cord-279343-ybncwweg	39	1	Crystals	crystal	NNS
cord-279343-ybncwweg	39	2	were	be	VBD
cord-279343-ybncwweg	39	3	obtained	obtain	VBN
cord-279343-ybncwweg	39	4	under	under	IN
cord-279343-ybncwweg	39	5	several	several	JJ
cord-279343-ybncwweg	39	6	conditions	condition	NNS
cord-279343-ybncwweg	39	7	that	that	WDT
cord-279343-ybncwweg	39	8	include	include	VBP
cord-279343-ybncwweg	39	9	polyethylene	polyethylene	NN
cord-279343-ybncwweg	39	10	glycol	glycol	NN
cord-279343-ybncwweg	39	11	with	with	IN
cord-279343-ybncwweg	39	12	various	various	JJ
cord-279343-ybncwweg	39	13	molecular	molecular	JJ
cord-279343-ybncwweg	39	14	masses	masse	NNS
cord-279343-ybncwweg	39	15	(	(	-LRB-
cord-279343-ybncwweg	39	16	2000	2000	CD
cord-279343-ybncwweg	39	17	-	-	SYM
cord-279343-ybncwweg	39	18	8000	8000	CD
cord-279343-ybncwweg	39	19	Da	Da	NNP
cord-279343-ybncwweg	39	20	)	)	-RRB-
cord-279343-ybncwweg	39	21	and	and	CC
cord-279343-ybncwweg	39	22	buffers	buffer	NNS
cord-279343-ybncwweg	39	23	with	with	IN
cord-279343-ybncwweg	39	24	a	a	DT
cord-279343-ybncwweg	39	25	pH	ph	NN
cord-279343-ybncwweg	39	26	between	between	IN
cord-279343-ybncwweg	39	27	6.0	6.0	CD
cord-279343-ybncwweg	39	28	and	and	CC
cord-279343-ybncwweg	39	29	8.0	8.0	CD
cord-279343-ybncwweg	39	30	.	.	.
cord-279343-ybncwweg	40	1	Crystals	crystal	NNS
cord-279343-ybncwweg	40	2	contained	contain	VBD
cord-279343-ybncwweg	40	3	one	one	CD
cord-279343-ybncwweg	40	4	molecule	molecule	NN
cord-279343-ybncwweg	40	5	per	per	IN
cord-279343-ybncwweg	40	6	asymmetric	asymmetric	JJ
cord-279343-ybncwweg	40	7	unit	unit	NN
cord-279343-ybncwweg	40	8	with	with	IN
cord-279343-ybncwweg	40	9	a	a	DT
cord-279343-ybncwweg	40	10	solvent	solvent	NN
cord-279343-ybncwweg	40	11	content	content	NN
cord-279343-ybncwweg	40	12	of	of	IN
cord-279343-ybncwweg	40	13	32.8	32.8	CD
cord-279343-ybncwweg	40	14	%	%	NN
cord-279343-ybncwweg	40	15	(	(	-LRB-
cord-279343-ybncwweg	40	16	v	v	NN
cord-279343-ybncwweg	40	17	/	/	SYM
cord-279343-ybncwweg	40	18	v	v	NN
cord-279343-ybncwweg	40	19	)	)	-RRB-
cord-279343-ybncwweg	41	1	(	(	-LRB-
cord-279343-ybncwweg	41	2	Matthew	Matthew	NNP
cord-279343-ybncwweg	41	3	's	's	POS
cord-279343-ybncwweg	41	4	coefficient	coefficient	NN
cord-279343-ybncwweg	41	5	of	of	IN
cord-279343-ybncwweg	41	6	1.8	1.8	CD
cord-279343-ybncwweg	41	7	)	)	-RRB-
cord-279343-ybncwweg	41	8	.	.	.
cord-279343-ybncwweg	42	1	Molecular	molecular	JJ
cord-279343-ybncwweg	42	2	replacement	replacement	NN
cord-279343-ybncwweg	42	3	rotation	rotation	NN
cord-279343-ybncwweg	42	4	and	and	CC
cord-279343-ybncwweg	42	5	translation	translation	NN
cord-279343-ybncwweg	42	6	correlation	correlation	NN
cord-279343-ybncwweg	42	7	coefficients	coefficient	NNS
cord-279343-ybncwweg	42	8	were	be	VBD
cord-279343-ybncwweg	42	9	ranked	rank	VBN
cord-279343-ybncwweg	42	10	and	and	CC
cord-279343-ybncwweg	42	11	yielded	yield	VBD
cord-279343-ybncwweg	42	12	a	a	DT
cord-279343-ybncwweg	42	13	single	single	JJ
cord-279343-ybncwweg	42	14	solution	solution	NN
cord-279343-ybncwweg	42	15	well	well	RB
cord-279343-ybncwweg	42	16	above	above	IN
cord-279343-ybncwweg	42	17	the	the	DT
cord-279343-ybncwweg	42	18	background	background	NN
cord-279343-ybncwweg	42	19	.	.	.
cord-279343-ybncwweg	43	1	The	the	DT
cord-279343-ybncwweg	43	2	initial	initial	JJ
cord-279343-ybncwweg	43	3	phased	phase	VBN
cord-279343-ybncwweg	43	4	map	map	NN
cord-279343-ybncwweg	43	5	had	have	VBD
cord-279343-ybncwweg	43	6	clear	clear	JJ
cord-279343-ybncwweg	43	7	electron	electron	NN
cord-279343-ybncwweg	43	8	density	density	NN
cord-279343-ybncwweg	43	9	for	for	IN
cord-279343-ybncwweg	43	10	both	both	CC
cord-279343-ybncwweg	43	11	the	the	DT
cord-279343-ybncwweg	43	12	main	main	JJ
cord-279343-ybncwweg	43	13	chains	chain	NNS
cord-279343-ybncwweg	43	14	and	and	CC
cord-279343-ybncwweg	43	15	the	the	DT
cord-279343-ybncwweg	43	16	side	side	NN
cord-279343-ybncwweg	43	17	-	-	HYPH
cord-279343-ybncwweg	43	18	chains	chain	NNS
cord-279343-ybncwweg	43	19	.	.	.
cord-279343-ybncwweg	44	1	After	after	IN
cord-279343-ybncwweg	44	2	rebuilding	rebuild	VBG
cord-279343-ybncwweg	44	3	of	of	IN
cord-279343-ybncwweg	44	4	loops	loop	NNS
cord-279343-ybncwweg	44	5	,	,	,
cord-279343-ybncwweg	44	6	the	the	DT
cord-279343-ybncwweg	44	7	electron	electron	NN
cord-279343-ybncwweg	44	8	density	density	NN
cord-279343-ybncwweg	44	9	was	be	VBD
cord-279343-ybncwweg	44	10	continuous	continuous	JJ
cord-279343-ybncwweg	44	11	throughout	throughout	IN
cord-279343-ybncwweg	44	12	the	the	DT
cord-279343-ybncwweg	44	13	structure	structure	NN
cord-279343-ybncwweg	44	14	and	and	CC
cord-279343-ybncwweg	44	15	the	the	DT
cord-279343-ybncwweg	44	16	final	final	JJ
cord-279343-ybncwweg	44	17	structure	structure	NN
cord-279343-ybncwweg	44	18	consists	consist	VBZ
cord-279343-ybncwweg	44	19	of	of	IN
cord-279343-ybncwweg	44	20	residues	residue	NNS
cord-279343-ybncwweg	44	21	260	260	CD
cord-279343-ybncwweg	44	22	-	-	SYM
cord-279343-ybncwweg	44	23	398	398	CD
cord-279343-ybncwweg	44	24	,	,	,
cord-279343-ybncwweg	44	25	with	with	IN
cord-279343-ybncwweg	44	26	Met282	met282	ADD
cord-279343-ybncwweg	44	27	modeled	model	VBN
cord-279343-ybncwweg	44	28	in	in	IN
cord-279343-ybncwweg	44	29	two	two	CD
cord-279343-ybncwweg	44	30	alternative	alternative	JJ
cord-279343-ybncwweg	44	31	conformations	conformation	NNS
cord-279343-ybncwweg	44	32	.	.	.
cord-279343-ybncwweg	45	1	The	the	DT
cord-279343-ybncwweg	45	2	final	final	JJ
cord-279343-ybncwweg	45	3	refined	refined	JJ
cord-279343-ybncwweg	45	4	crystallographic	crystallographic	JJ
cord-279343-ybncwweg	45	5	R	r	NN
cord-279343-ybncwweg	45	6	-	-	HYPH
cord-279343-ybncwweg	45	7	factors	factor	NNS
cord-279343-ybncwweg	45	8	are	be	VBP
cord-279343-ybncwweg	45	9	17.75	17.75	CD
cord-279343-ybncwweg	45	10	%	%	NN
cord-279343-ybncwweg	45	11	and	and	CC
cord-279343-ybncwweg	45	12	19.3	19.3	CD
cord-279343-ybncwweg	45	13	%	%	NN
cord-279343-ybncwweg	45	14	for	for	IN
cord-279343-ybncwweg	45	15	R	r	NN
cord-279343-ybncwweg	45	16	work	work	NN
cord-279343-ybncwweg	45	17	and	and	CC
cord-279343-ybncwweg	45	18	R	r	NN
cord-279343-ybncwweg	45	19	free	free	JJ
cord-279343-ybncwweg	45	20	,	,	,
cord-279343-ybncwweg	45	21	respectively	respectively	RB
cord-279343-ybncwweg	45	22	,	,	,
cord-279343-ybncwweg	45	23	at	at	IN
cord-279343-ybncwweg	45	24	1.41	1.41	CD
cord-279343-ybncwweg	45	25	Å	å	NN
cord-279343-ybncwweg	45	26	resolution	resolution	NN
cord-279343-ybncwweg	45	27	(	(	-LRB-
cord-279343-ybncwweg	45	28	Table	table	NN
cord-279343-ybncwweg	45	29	1	1	CD
cord-279343-ybncwweg	45	30	)	)	-RRB-
cord-279343-ybncwweg	45	31	.	.	.
cord-279343-ybncwweg	46	1	The	the	DT
cord-279343-ybncwweg	46	2	overall	overall	JJ
cord-279343-ybncwweg	46	3	structure	structure	NN
cord-279343-ybncwweg	46	4	is	be	VBZ
cord-279343-ybncwweg	46	5	a	a	DT
cord-279343-ybncwweg	46	6	typical	typical	JJ
cord-279343-ybncwweg	46	7	long	long	JJ
cord-279343-ybncwweg	46	8	-	-	HYPH
cord-279343-ybncwweg	46	9	form	form	NN
cord-279343-ybncwweg	46	10	C	c	NN
cord-279343-ybncwweg	46	11	-	-	HYPH
cord-279343-ybncwweg	46	12	type	type	NN
cord-279343-ybncwweg	46	13	lectin	lectin	NN
cord-279343-ybncwweg	46	14	,	,	,
cord-279343-ybncwweg	46	15	and	and	CC
cord-279343-ybncwweg	46	16	the	the	DT
cord-279343-ybncwweg	46	17	CRD	crd	NN
cord-279343-ybncwweg	46	18	portion	portion	NN
cord-279343-ybncwweg	46	19	superimposes	superimpose	VBZ
cord-279343-ybncwweg	46	20	with	with	IN
cord-279343-ybncwweg	46	21	a	a	DT
cord-279343-ybncwweg	46	22	root	root	NN
cord-279343-ybncwweg	46	23	-	-	HYPH
cord-279343-ybncwweg	46	24	meansquare	meansquare	NN
cord-279343-ybncwweg	46	25	(	(	-LRB-
cord-279343-ybncwweg	46	26	r.m.s	r.m.s	NN
cord-279343-ybncwweg	46	27	)	)	-RRB-
cord-279343-ybncwweg	46	28	deviation	deviation	NN
cord-279343-ybncwweg	46	29	of	of	IN
cord-279343-ybncwweg	46	30	0.67	0.67	CD
cord-279343-ybncwweg	46	31	Å	å	NN
cord-279343-ybncwweg	46	32	(	(	-LRB-
cord-279343-ybncwweg	46	33	for	for	IN
cord-279343-ybncwweg	46	34	126	126	CD
cord-279343-ybncwweg	46	35	C	c	NN
cord-279343-ybncwweg	46	36	a	a	DT
cord-279343-ybncwweg	46	37	atoms	atom	NNS
cord-279343-ybncwweg	46	38	)	)	-RRB-
cord-279343-ybncwweg	46	39	to	to	IN
cord-279343-ybncwweg	46	40	the	the	DT
cord-279343-ybncwweg	46	41	CRD	crd	NN
cord-279343-ybncwweg	46	42	-	-	HYPH
cord-279343-ybncwweg	46	43	only	only	JJ
cord-279343-ybncwweg	46	44	structure	structure	NN
cord-279343-ybncwweg	46	45	(	(	-LRB-
cord-279343-ybncwweg	46	46	Figure	figure	NN
cord-279343-ybncwweg	46	47	1(b	1(b	CD
cord-279343-ybncwweg	46	48	)	)	-RRB-
cord-279343-ybncwweg	46	49	)	)	-RRB-
cord-279343-ybncwweg	46	50	.	.	.
cord-279343-ybncwweg	47	1	18	18	CD
cord-279343-ybncwweg	48	1	Although	although	IN
cord-279343-ybncwweg	48	2	both	both	DT
cord-279343-ybncwweg	48	3	mannose	mannose	NN
cord-279343-ybncwweg	48	4	and	and	CC
cord-279343-ybncwweg	48	5	calcium	calcium	NN
cord-279343-ybncwweg	48	6	were	be	VBD
cord-279343-ybncwweg	48	7	present	present	JJ
cord-279343-ybncwweg	48	8	in	in	IN
cord-279343-ybncwweg	48	9	the	the	DT
cord-279343-ybncwweg	48	10	crystallization	crystallization	NN
cord-279343-ybncwweg	48	11	solution	solution	NN
cord-279343-ybncwweg	48	12	,	,	,
cord-279343-ybncwweg	48	13	only	only	JJ
cord-279343-ybncwweg	48	14	calcium	calcium	NN
cord-279343-ybncwweg	48	15	was	be	VBD
cord-279343-ybncwweg	48	16	observed	observe	VBN
cord-279343-ybncwweg	48	17	bound	bind	VBN
cord-279343-ybncwweg	48	18	in	in	IN
cord-279343-ybncwweg	48	19	the	the	DT
cord-279343-ybncwweg	48	20	canonical	canonical	JJ
cord-279343-ybncwweg	48	21	calcium	calcium	NN
cord-279343-ybncwweg	48	22	binding	binding	NN
cord-279343-ybncwweg	48	23	site	site	NN
cord-279343-ybncwweg	48	24	.	.	.
cord-279343-ybncwweg	49	1	This	this	DT
cord-279343-ybncwweg	49	2	structure	structure	NN
cord-279343-ybncwweg	49	3	contains	contain	VBZ
cord-279343-ybncwweg	49	4	additional	additional	JJ
cord-279343-ybncwweg	49	5	residues	residue	NNS
cord-279343-ybncwweg	49	6	at	at	IN
cord-279343-ybncwweg	49	7	both	both	CC
cord-279343-ybncwweg	49	8	the	the	DT
cord-279343-ybncwweg	49	9	amino	amino	NN
cord-279343-ybncwweg	49	10	and	and	CC
cord-279343-ybncwweg	49	11	carboxyl	carboxyl	NN
cord-279343-ybncwweg	49	12	termini	terminus	NNS
cord-279343-ybncwweg	49	13	including	include	VBG
cord-279343-ybncwweg	49	14	a	a	DT
cord-279343-ybncwweg	49	15	disulfide	disulfide	JJ
cord-279343-ybncwweg	49	16	bond	bond	NN
cord-279343-ybncwweg	49	17	linking	link	VBG
cord-279343-ybncwweg	49	18	the	the	DT
cord-279343-ybncwweg	49	19	two	two	CD
cord-279343-ybncwweg	49	20	termini	terminus	NNS
cord-279343-ybncwweg	49	21	as	as	RB
cord-279343-ybncwweg	49	22	well	well	RB
cord-279343-ybncwweg	49	23	as	as	IN
cord-279343-ybncwweg	49	24	a	a	DT
cord-279343-ybncwweg	49	25	short	short	JJ
cord-279343-ybncwweg	49	26	a	a	DT
cord-279343-ybncwweg	49	27	-	-	HYPH
cord-279343-ybncwweg	49	28	helix	helix	NN
cord-279343-ybncwweg	49	29	at	at	IN
cord-279343-ybncwweg	49	30	the	the	DT
cord-279343-ybncwweg	49	31	beginning	beginning	NN
cord-279343-ybncwweg	49	32	of	of	IN
cord-279343-ybncwweg	49	33	the	the	DT
cord-279343-ybncwweg	49	34	repeat	repeat	NN
cord-279343-ybncwweg	49	35	domain	domain	NN
cord-279343-ybncwweg	49	36	.	.	.
cord-279343-ybncwweg	50	1	Additional	additional	JJ
cord-279343-ybncwweg	50	2	amino	amino	NN
cord-279343-ybncwweg	50	3	acids	acid	NNS
cord-279343-ybncwweg	50	4	were	be	VBD
cord-279343-ybncwweg	50	5	present	present	JJ
cord-279343-ybncwweg	50	6	in	in	IN
cord-279343-ybncwweg	50	7	both	both	CC
cord-279343-ybncwweg	50	8	the	the	DT
cord-279343-ybncwweg	50	9	N	N	NNP
cord-279343-ybncwweg	50	10	and	and	CC
cord-279343-ybncwweg	50	11	C	C	NNP
cord-279343-ybncwweg	50	12	termini	terminus	NNS
cord-279343-ybncwweg	50	13	compared	compare	VBN
cord-279343-ybncwweg	50	14	with	with	IN
cord-279343-ybncwweg	50	15	the	the	DT
cord-279343-ybncwweg	50	16	CRD	crd	NN
cord-279343-ybncwweg	50	17	-	-	HYPH
cord-279343-ybncwweg	50	18	only	only	JJ
cord-279343-ybncwweg	50	19	structure	structure	NN
cord-279343-ybncwweg	50	20	.	.	.
cord-279343-ybncwweg	51	1	At	at	IN
cord-279343-ybncwweg	51	2	the	the	DT
cord-279343-ybncwweg	51	3	C	c	NN
cord-279343-ybncwweg	51	4	-	-	HYPH
cord-279343-ybncwweg	51	5	terminus	terminus	NN
cord-279343-ybncwweg	51	6	we	-PRON-	PRP
cord-279343-ybncwweg	51	7	observed	observe	VBD
cord-279343-ybncwweg	51	8	additional	additional	JJ
cord-279343-ybncwweg	51	9	density	density	NN
cord-279343-ybncwweg	51	10	for	for	IN
cord-279343-ybncwweg	51	11	amino	amino	JJ
cord-279343-ybncwweg	51	12	acids	acid	NNS
cord-279343-ybncwweg	51	13	395	395	CD
cord-279343-ybncwweg	51	14	-	-	HYPH
cord-279343-ybncwweg	51	15	398	398	CD
cord-279343-ybncwweg	51	16	,	,	,
cord-279343-ybncwweg	51	17	including	include	VBG
cord-279343-ybncwweg	51	18	a	a	DT
cord-279343-ybncwweg	51	19	disulfide	disulfide	JJ
cord-279343-ybncwweg	51	20	bond	bond	NN
cord-279343-ybncwweg	51	21	between	between	IN
cord-279343-ybncwweg	51	22	Cys395	Cys395	.
cord-279343-ybncwweg	51	23	and	and	CC
cord-279343-ybncwweg	51	24	Cys265	Cys265	NNP
cord-279343-ybncwweg	51	25	,	,	,
cord-279343-ybncwweg	51	26	which	which	WDT
cord-279343-ybncwweg	51	27	links	link	VBZ
cord-279343-ybncwweg	51	28	both	both	CC
cord-279343-ybncwweg	51	29	the	the	DT
cord-279343-ybncwweg	51	30	N	N	NNP
cord-279343-ybncwweg	51	31	-	-	HYPH
cord-279343-ybncwweg	51	32	and	and	CC
cord-279343-ybncwweg	51	33	C	C	NNP
cord-279343-ybncwweg	51	34	-	-	HYPH
cord-279343-ybncwweg	51	35	termini	termini	NNP
cord-279343-ybncwweg	51	36	into	into	IN
cord-279343-ybncwweg	51	37	close	close	JJ
cord-279343-ybncwweg	51	38	proximity	proximity	NN
cord-279343-ybncwweg	51	39	(	(	-LRB-
cord-279343-ybncwweg	51	40	Figure	figure	NN
cord-279343-ybncwweg	51	41	1	1	CD
cord-279343-ybncwweg	51	42	)	)	-RRB-
cord-279343-ybncwweg	51	43	.	.	.
cord-279343-ybncwweg	52	1	As	as	IN
cord-279343-ybncwweg	52	2	a	a	DT
cord-279343-ybncwweg	52	3	result	result	NN
cord-279343-ybncwweg	52	4	,	,	,
cord-279343-ybncwweg	52	5	the	the	DT
cord-279343-ybncwweg	52	6	ring	ring	NN
cord-279343-ybncwweg	52	7	of	of	IN
cord-279343-ybncwweg	52	8	the	the	DT
cord-279343-ybncwweg	52	9	N	n	CD
cord-279343-ybncwweg	52	10	-	-	HYPH
cord-279343-ybncwweg	52	11	terminal	terminal	NN
cord-279343-ybncwweg	52	12	histidine	histidine	NN
cord-279343-ybncwweg	52	13	residue	residue	NN
cord-279343-ybncwweg	52	14	(	(	-LRB-
cord-279343-ybncwweg	52	15	His267	His267	NNP
cord-279343-ybncwweg	52	16	)	)	-RRB-
cord-279343-ybncwweg	52	17	stacks	stack	VBZ
cord-279343-ybncwweg	52	18	against	against	IN
cord-279343-ybncwweg	52	19	the	the	DT
cord-279343-ybncwweg	52	20	ring	ring	NN
cord-279343-ybncwweg	52	21	of	of	IN
cord-279343-ybncwweg	52	22	the	the	DT
cord-279343-ybncwweg	52	23	C	C	NNP
cord-279343-ybncwweg	52	24	-	-	HYPH
cord-279343-ybncwweg	52	25	terminal	terminal	NN
cord-279343-ybncwweg	52	26	Phe396	phe396	CD
cord-279343-ybncwweg	52	27	.	.	.
cord-279343-ybncwweg	53	1	The	the	DT
cord-279343-ybncwweg	53	2	helical	helical	JJ
cord-279343-ybncwweg	53	3	repeat	repeat	NN
cord-279343-ybncwweg	53	4	domain	domain	NN
cord-279343-ybncwweg	53	5	has	have	VBZ
cord-279343-ybncwweg	53	6	been	be	VBN
cord-279343-ybncwweg	53	7	shown	show	VBN
cord-279343-ybncwweg	53	8	to	to	TO
cord-279343-ybncwweg	53	9	be	be	VB
cord-279343-ybncwweg	53	10	responsible	responsible	JJ
cord-279343-ybncwweg	53	11	for	for	IN
cord-279343-ybncwweg	53	12	tetramerization	tetramerization	NN
cord-279343-ybncwweg	53	13	of	of	IN
cord-279343-ybncwweg	53	14	the	the	DT
cord-279343-ybncwweg	53	15	receptor	receptor	NN
cord-279343-ybncwweg	53	16	.	.	.
cord-279343-ybncwweg	54	1	Our	-PRON-	PRP$
cord-279343-ybncwweg	54	2	DC	DC	NNP
cord-279343-ybncwweg	54	3	-	-	HYPH
cord-279343-ybncwweg	54	4	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	54	5	R8	r8	NN
cord-279343-ybncwweg	54	6	construct	construct	NN
cord-279343-ybncwweg	54	7	contains	contain	VBZ
cord-279343-ybncwweg	54	8	the	the	DT
cord-279343-ybncwweg	54	9	last	last	JJ
cord-279343-ybncwweg	54	10	repeat	repeat	NN
cord-279343-ybncwweg	54	11	that	that	WDT
cord-279343-ybncwweg	54	12	immediately	immediately	RB
cord-279343-ybncwweg	54	13	precedes	precede	VBZ
cord-279343-ybncwweg	54	14	the	the	DT
cord-279343-ybncwweg	54	15	CRD	CRD	NNP
cord-279343-ybncwweg	54	16	domain	domain	NN
cord-279343-ybncwweg	54	17	.	.	.
cord-279343-ybncwweg	55	1	This	this	DT
cord-279343-ybncwweg	55	2	repeat	repeat	NN
cord-279343-ybncwweg	55	3	region	region	NN
cord-279343-ybncwweg	55	4	encompasses	encompass	VBZ
cord-279343-ybncwweg	55	5	residues	residue	NNS
cord-279343-ybncwweg	55	6	Gln249-Cys265	Gln249-Cys265	NNP
cord-279343-ybncwweg	55	7	.	.	.
cord-279343-ybncwweg	56	1	A	a	DT
cord-279343-ybncwweg	56	2	portion	portion	NN
cord-279343-ybncwweg	56	3	of	of	IN
cord-279343-ybncwweg	56	4	this	this	DT
cord-279343-ybncwweg	56	5	repeat	repeat	NN
cord-279343-ybncwweg	56	6	,	,	,
cord-279343-ybncwweg	56	7	Ala260-Cys265	Ala260-Cys265	NNP
cord-279343-ybncwweg	56	8	,	,	,
cord-279343-ybncwweg	56	9	is	be	VBZ
cord-279343-ybncwweg	56	10	ordered	order	VBN
cord-279343-ybncwweg	56	11	in	in	IN
cord-279343-ybncwweg	56	12	the	the	DT
cord-279343-ybncwweg	56	13	structure	structure	NN
cord-279343-ybncwweg	56	14	and	and	CC
cord-279343-ybncwweg	56	15	forms	form	VBZ
cord-279343-ybncwweg	56	16	a	a	DT
cord-279343-ybncwweg	56	17	short	short	JJ
cord-279343-ybncwweg	56	18	a	a	DT
cord-279343-ybncwweg	56	19	-	-	HYPH
cord-279343-ybncwweg	56	20	helix	helix	NN
cord-279343-ybncwweg	56	21	.	.	.
cord-279343-ybncwweg	57	1	Although	although	IN
cord-279343-ybncwweg	57	2	the	the	DT
cord-279343-ybncwweg	57	3	rest	rest	NN
cord-279343-ybncwweg	57	4	of	of	IN
cord-279343-ybncwweg	57	5	the	the	DT
cord-279343-ybncwweg	57	6	R8	R8	NNP
cord-279343-ybncwweg	57	7	repeat	repeat	NN
cord-279343-ybncwweg	57	8	appears	appear	VBZ
cord-279343-ybncwweg	57	9	disordered	disordered	JJ
cord-279343-ybncwweg	57	10	in	in	IN
cord-279343-ybncwweg	57	11	our	-PRON-	PRP$
cord-279343-ybncwweg	57	12	crystal	crystal	NN
cord-279343-ybncwweg	57	13	,	,	,
cord-279343-ybncwweg	57	14	presumably	presumably	RB
cord-279343-ybncwweg	57	15	due	due	IN
cord-279343-ybncwweg	57	16	to	to	IN
cord-279343-ybncwweg	57	17	the	the	DT
cord-279343-ybncwweg	57	18	proximity	proximity	NN
cord-279343-ybncwweg	57	19	to	to	IN
cord-279343-ybncwweg	57	20	the	the	DT
cord-279343-ybncwweg	57	21	N	n	CD
cord-279343-ybncwweg	57	22	terminus	terminus	NN
cord-279343-ybncwweg	57	23	of	of	IN
cord-279343-ybncwweg	57	24	the	the	DT
cord-279343-ybncwweg	57	25	expressed	express	VBN
cord-279343-ybncwweg	57	26	recombinant	recombinant	JJ
cord-279343-ybncwweg	57	27	R8	R8	NNP
cord-279343-ybncwweg	57	28	construct	construct	NN
cord-279343-ybncwweg	57	29	,	,	,
cord-279343-ybncwweg	57	30	the	the	DT
cord-279343-ybncwweg	57	31	presence	presence	NN
cord-279343-ybncwweg	57	32	of	of	IN
cord-279343-ybncwweg	57	33	a	a	DT
cord-279343-ybncwweg	57	34	short	short	JJ
cord-279343-ybncwweg	57	35	helix	helix	NN
cord-279343-ybncwweg	57	36	is	be	VBZ
cord-279343-ybncwweg	57	37	consistent	consistent	JJ
cord-279343-ybncwweg	57	38	with	with	IN
cord-279343-ybncwweg	57	39	the	the	DT
cord-279343-ybncwweg	57	40	secondary	secondary	JJ
cord-279343-ybncwweg	57	41	structure	structure	NN
cord-279343-ybncwweg	57	42	prediction	prediction	NN
cord-279343-ybncwweg	57	43	that	that	IN
cord-279343-ybncwweg	57	44	the	the	DT
cord-279343-ybncwweg	57	45	repeat	repeat	NN
cord-279343-ybncwweg	57	46	domain	domain	NN
cord-279343-ybncwweg	57	47	is	be	VBZ
cord-279343-ybncwweg	57	48	mainly	mainly	RB
cord-279343-ybncwweg	57	49	a	a	DT
cord-279343-ybncwweg	57	50	-	-	HYPH
cord-279343-ybncwweg	57	51	helical	helical	NN
cord-279343-ybncwweg	57	52	.	.	.
cord-279343-ybncwweg	58	1	The	the	DT
cord-279343-ybncwweg	58	2	N	n	CD
cord-279343-ybncwweg	58	3	-	-	HYPH
cord-279343-ybncwweg	58	4	terminal	terminal	JJ
cord-279343-ybncwweg	58	5	CRD	crd	NN
cord-279343-ybncwweg	58	6	disulfide	disulfide	NN
cord-279343-ybncwweg	58	7	bond	bond	NN
cord-279343-ybncwweg	58	8	(	(	-LRB-
cord-279343-ybncwweg	58	9	Cys265-Cys395	Cys265-Cys395	NNP
cord-279343-ybncwweg	58	10	)	)	-RRB-
cord-279343-ybncwweg	58	11	and	and	CC
cord-279343-ybncwweg	58	12	the	the	DT
cord-279343-ybncwweg	58	13	helical	helical	JJ
cord-279343-ybncwweg	58	14	repeat	repeat	NN
cord-279343-ybncwweg	58	15	conformation	conformation	NN
cord-279343-ybncwweg	58	16	was	be	VBD
cord-279343-ybncwweg	58	17	observed	observe	VBN
cord-279343-ybncwweg	58	18	recently	recently	RB
cord-279343-ybncwweg	58	19	in	in	IN
cord-279343-ybncwweg	58	20	the	the	DT
cord-279343-ybncwweg	58	21	structure	structure	NN
cord-279343-ybncwweg	58	22	of	of	IN
cord-279343-ybncwweg	58	23	DC	DC	NNP
cord-279343-ybncwweg	58	24	-	-	HYPH
cord-279343-ybncwweg	58	25	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	58	26	R7	R7	NNP
cord-279343-ybncwweg	58	27	(	(	-LRB-
cord-279343-ybncwweg	58	28	CRD	crd	NN
cord-279343-ybncwweg	58	29	with	with	IN
cord-279343-ybncwweg	58	30	its	-PRON-	PRP$
cord-279343-ybncwweg	58	31	last	last	JJ
cord-279343-ybncwweg	58	32	two	two	CD
cord-279343-ybncwweg	58	33	repeats	repeat	NNS
cord-279343-ybncwweg	58	34	)	)	-RRB-
cord-279343-ybncwweg	58	35	.	.	.
cord-279343-ybncwweg	59	1	19	19	CD
cord-279343-ybncwweg	59	2	,	,	,
cord-279343-ybncwweg	59	3	22	22	CD
cord-279343-ybncwweg	59	4	The	the	DT
cord-279343-ybncwweg	59	5	r.m.s	r.m.s	JJ
cord-279343-ybncwweg	59	6	deviation	deviation	NN
cord-279343-ybncwweg	59	7	between	between	IN
cord-279343-ybncwweg	59	8	the	the	DT
cord-279343-ybncwweg	59	9	CRD	CRD	NNP
cord-279343-ybncwweg	59	10	domain	domain	NN
cord-279343-ybncwweg	59	11	of	of	IN
cord-279343-ybncwweg	59	12	DC	DC	NNP
cord-279343-ybncwweg	59	13	-	-	HYPH
cord-279343-ybncwweg	59	14	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	59	15	R8	R8	NNP
cord-279343-ybncwweg	59	16	and	and	CC
cord-279343-ybncwweg	59	17	that	that	DT
cord-279343-ybncwweg	59	18	of	of	IN
cord-279343-ybncwweg	59	19	R7	R7	NNP
cord-279343-ybncwweg	59	20	is	be	VBZ
cord-279343-ybncwweg	59	21	0.76	0.76	CD
cord-279343-ybncwweg	59	22	Å	å	NN
cord-279343-ybncwweg	59	23	for	for	IN
cord-279343-ybncwweg	59	24	129	129	CD
cord-279343-ybncwweg	59	25	C	c	NN
cord-279343-ybncwweg	59	26	a	a	DT
cord-279343-ybncwweg	59	27	atoms	atom	NNS
cord-279343-ybncwweg	59	28	.	.	.
cord-279343-ybncwweg	60	1	However	however	RB
cord-279343-ybncwweg	60	2	,	,	,
cord-279343-ybncwweg	60	3	the	the	DT
cord-279343-ybncwweg	60	4	hinge	hinge	NN
cord-279343-ybncwweg	60	5	angle	angle	NN
cord-279343-ybncwweg	60	6	between	between	IN
cord-279343-ybncwweg	60	7	the	the	DT
cord-279343-ybncwweg	60	8	CRD	crd	NN
cord-279343-ybncwweg	60	9	and	and	CC
cord-279343-ybncwweg	60	10	the	the	DT
cord-279343-ybncwweg	60	11	repeat	repeat	NN
cord-279343-ybncwweg	60	12	domain	domain	NN
cord-279343-ybncwweg	60	13	differs	differ	VBZ
cord-279343-ybncwweg	60	14	by	by	IN
cord-279343-ybncwweg	60	15	about	about	RB
cord-279343-ybncwweg	60	16	408	408	CD
cord-279343-ybncwweg	60	17	(	(	-LRB-
cord-279343-ybncwweg	60	18	1008	1008	CD
cord-279343-ybncwweg	60	19	and	and	CC
cord-279343-ybncwweg	60	20	608	608	CD
cord-279343-ybncwweg	60	21	,	,	,
cord-279343-ybncwweg	60	22	respectively	respectively	RB
cord-279343-ybncwweg	60	23	)	)	-RRB-
cord-279343-ybncwweg	60	24	between	between	IN
cord-279343-ybncwweg	60	25	the	the	DT
cord-279343-ybncwweg	60	26	two	two	CD
cord-279343-ybncwweg	60	27	structures	structure	NNS
cord-279343-ybncwweg	60	28	,	,	,
cord-279343-ybncwweg	60	29	indicating	indicate	VBG
cord-279343-ybncwweg	60	30	a	a	DT
cord-279343-ybncwweg	60	31	domain	domain	NN
cord-279343-ybncwweg	60	32	flexibility	flexibility	NN
cord-279343-ybncwweg	60	33	between	between	IN
cord-279343-ybncwweg	60	34	the	the	DT
cord-279343-ybncwweg	60	35	CRD	crd	NN
cord-279343-ybncwweg	60	36	and	and	CC
cord-279343-ybncwweg	60	37	the	the	DT
cord-279343-ybncwweg	60	38	repeat	repeat	NN
cord-279343-ybncwweg	60	39	domain	domain	NN
cord-279343-ybncwweg	60	40	of	of	IN
cord-279343-ybncwweg	60	41	the	the	DT
cord-279343-ybncwweg	60	42	receptor	receptor	NN
cord-279343-ybncwweg	60	43	(	(	-LRB-
cord-279343-ybncwweg	60	44	Figure	figure	NN
cord-279343-ybncwweg	60	45	1	1	CD
cord-279343-ybncwweg	60	46	)	)	-RRB-
cord-279343-ybncwweg	60	47	.	.	.
cord-279343-ybncwweg	61	1	The	the	DT
cord-279343-ybncwweg	61	2	primary	primary	JJ
cord-279343-ybncwweg	61	3	calcium	calcium	NN
cord-279343-ybncwweg	61	4	site	site	NN
cord-279343-ybncwweg	61	5	involved	involve	VBN
cord-279343-ybncwweg	61	6	in	in	IN
cord-279343-ybncwweg	61	7	binding	bind	VBG
cord-279343-ybncwweg	61	8	 	 	_SP
cord-279343-ybncwweg	61	9	where	where	WRB
cord-279343-ybncwweg	61	10	F	F	NNP
cord-279343-ybncwweg	61	11	c	c	NN
cord-279343-ybncwweg	61	12	is	be	VBZ
cord-279343-ybncwweg	61	13	the	the	DT
cord-279343-ybncwweg	61	14	calculated	calculated	JJ
cord-279343-ybncwweg	61	15	and	and	CC
cord-279343-ybncwweg	61	16	F	F	NNP
cord-279343-ybncwweg	61	17	o	o	NNP
cord-279343-ybncwweg	61	18	is	be	VBZ
cord-279343-ybncwweg	61	19	the	the	DT
cord-279343-ybncwweg	61	20	observed	observed	JJ
cord-279343-ybncwweg	61	21	structure	structure	NN
cord-279343-ybncwweg	61	22	factor	factor	NN
cord-279343-ybncwweg	61	23	amplitude	amplitude	NN
cord-279343-ybncwweg	61	24	of	of	IN
cord-279343-ybncwweg	61	25	reflection	reflection	NN
cord-279343-ybncwweg	61	26	h	h	NN
cord-279343-ybncwweg	61	27	for	for	IN
cord-279343-ybncwweg	61	28	the	the	DT
cord-279343-ybncwweg	61	29	working	working	NN
cord-279343-ybncwweg	61	30	or	or	CC
cord-279343-ybncwweg	61	31	5	5	CD
cord-279343-ybncwweg	61	32	%	%	NN
cord-279343-ybncwweg	61	33	free	free	JJ
cord-279343-ybncwweg	61	34	set	set	NN
cord-279343-ybncwweg	61	35	,	,	,
cord-279343-ybncwweg	61	36	respectively	respectively	RB
cord-279343-ybncwweg	61	37	.	.	.
cord-279343-ybncwweg	62	1	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	62	2	(	(	-LRB-
cord-279343-ybncwweg	62	3	Ca2	Ca2	NNP
cord-279343-ybncwweg	62	4	)	)	-RRB-
cord-279343-ybncwweg	62	5	has	have	VBZ
cord-279343-ybncwweg	62	6	a	a	DT
cord-279343-ybncwweg	62	7	well	well	RB
cord-279343-ybncwweg	62	8	-	-	HYPH
cord-279343-ybncwweg	62	9	ordered	order	VBN
cord-279343-ybncwweg	62	10	calcium	calcium	NN
cord-279343-ybncwweg	62	11	ion	ion	NN
cord-279343-ybncwweg	62	12	in	in	IN
cord-279343-ybncwweg	62	13	this	this	DT
cord-279343-ybncwweg	62	14	structure	structure	NN
cord-279343-ybncwweg	62	15	.	.	.
cord-279343-ybncwweg	63	1	The	the	DT
cord-279343-ybncwweg	63	2	amino	amino	NN
cord-279343-ybncwweg	63	3	acid	acid	NN
cord-279343-ybncwweg	63	4	residues	residue	NNS
cord-279343-ybncwweg	63	5	involved	involve	VBN
cord-279343-ybncwweg	63	6	directly	directly	RB
cord-279343-ybncwweg	63	7	in	in	IN
cord-279343-ybncwweg	63	8	coordinating	coordinate	VBG
cord-279343-ybncwweg	63	9	the	the	DT
cord-279343-ybncwweg	63	10	calcium	calcium	NN
cord-279343-ybncwweg	63	11	ion	ion	NN
cord-279343-ybncwweg	63	12	are	be	VBP
cord-279343-ybncwweg	63	13	Glu359	Glu359	NNS
cord-279343-ybncwweg	63	14	,	,	,
cord-279343-ybncwweg	63	15	Asn361	asn361	CD
cord-279343-ybncwweg	63	16	,	,	,
cord-279343-ybncwweg	63	17	Glu366	Glu366	NNS
cord-279343-ybncwweg	63	18	,	,	,
cord-279343-ybncwweg	63	19	and	and	CC
cord-279343-ybncwweg	63	20	Asp378	Asp378	NNP
cord-279343-ybncwweg	63	21	,	,	,
cord-279343-ybncwweg	63	22	and	and	CC
cord-279343-ybncwweg	63	23	a	a	DT
cord-279343-ybncwweg	63	24	water	water	NN
cord-279343-ybncwweg	63	25	molecule	molecule	NN
cord-279343-ybncwweg	63	26	(	(	-LRB-
cord-279343-ybncwweg	63	27	W19	W19	NNP
cord-279343-ybncwweg	63	28	)	)	-RRB-
cord-279343-ybncwweg	63	29	.	.	.
cord-279343-ybncwweg	64	1	With	with	IN
cord-279343-ybncwweg	64	2	the	the	DT
cord-279343-ybncwweg	64	3	exception	exception	NN
cord-279343-ybncwweg	64	4	of	of	IN
cord-279343-ybncwweg	64	5	Asn377	asn377	CD
cord-279343-ybncwweg	64	6	,	,	,
cord-279343-ybncwweg	64	7	which	which	WDT
cord-279343-ybncwweg	64	8	is	be	VBZ
cord-279343-ybncwweg	64	9	rotated	rotate	VBN
cord-279343-ybncwweg	64	10	out	out	IN
cord-279343-ybncwweg	64	11	of	of	IN
cord-279343-ybncwweg	64	12	the	the	DT
cord-279343-ybncwweg	64	13	calcium	calcium	NN
cord-279343-ybncwweg	64	14	coordination	coordination	NN
cord-279343-ybncwweg	64	15	,	,	,
cord-279343-ybncwweg	64	16	the	the	DT
cord-279343-ybncwweg	64	17	ligand	ligand	NN
cord-279343-ybncwweg	64	18	positions	position	NNS
cord-279343-ybncwweg	64	19	are	be	VBP
cord-279343-ybncwweg	64	20	well	well	RB
cord-279343-ybncwweg	64	21	conserved	conserve	VBN
cord-279343-ybncwweg	64	22	between	between	IN
cord-279343-ybncwweg	64	23	the	the	DT
cord-279343-ybncwweg	64	24	R8	r8	NN
cord-279343-ybncwweg	64	25	and	and	CC
cord-279343-ybncwweg	64	26	CRD	crd	NN
cord-279343-ybncwweg	64	27	-	-	HYPH
cord-279343-ybncwweg	64	28	only	only	JJ
cord-279343-ybncwweg	64	29	structures	structure	NNS
cord-279343-ybncwweg	64	30	of	of	IN
cord-279343-ybncwweg	64	31	DC	DC	NNP
cord-279343-ybncwweg	64	32	-	-	HYPH
cord-279343-ybncwweg	64	33	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	64	34	(	(	-LRB-
cord-279343-ybncwweg	64	35	Figure	figure	NN
cord-279343-ybncwweg	64	36	2	2	CD
cord-279343-ybncwweg	64	37	(	(	-LRB-
cord-279343-ybncwweg	64	38	a	a	LS
cord-279343-ybncwweg	64	39	)	)	-RRB-
cord-279343-ybncwweg	64	40	and	and	CC
cord-279343-ybncwweg	64	41	Table	Table	NNP
cord-279343-ybncwweg	64	42	2	2	CD
cord-279343-ybncwweg	64	43	)	)	-RRB-
cord-279343-ybncwweg	64	44	.	.	.
cord-279343-ybncwweg	65	1	In	in	IN
cord-279343-ybncwweg	65	2	contrast	contrast	NN
cord-279343-ybncwweg	65	3	,	,	,
cord-279343-ybncwweg	65	4	no	no	DT
cord-279343-ybncwweg	65	5	attributable	attributable	JJ
cord-279343-ybncwweg	65	6	electron	electron	NN
cord-279343-ybncwweg	65	7	density	density	NN
cord-279343-ybncwweg	65	8	was	be	VBD
cord-279343-ybncwweg	65	9	found	find	VBN
cord-279343-ybncwweg	65	10	near	near	IN
cord-279343-ybncwweg	65	11	the	the	DT
cord-279343-ybncwweg	65	12	two	two	CD
cord-279343-ybncwweg	65	13	auxiliary	auxiliary	JJ
cord-279343-ybncwweg	65	14	calcium	calcium	NN
cord-279343-ybncwweg	65	15	ions	ion	NNS
cord-279343-ybncwweg	65	16	(	(	-LRB-
cord-279343-ybncwweg	65	17	Ca1	ca1	NN
cord-279343-ybncwweg	65	18	and	and	CC
cord-279343-ybncwweg	65	19	Ca3	ca3	NN
cord-279343-ybncwweg	65	20	)	)	-RRB-
cord-279343-ybncwweg	65	21	binding	binding	NN
cord-279343-ybncwweg	65	22	site	site	NN
cord-279343-ybncwweg	65	23	and	and	CC
cord-279343-ybncwweg	65	24	the	the	DT
cord-279343-ybncwweg	65	25	two	two	CD
cord-279343-ybncwweg	65	26	residues	residue	NNS
cord-279343-ybncwweg	65	27	coordinating	coordinate	VBG
cord-279343-ybncwweg	65	28	the	the	DT
cord-279343-ybncwweg	65	29	auxiliary	auxiliary	JJ
cord-279343-ybncwweg	65	30	calcium	calcium	NN
cord-279343-ybncwweg	65	31	,	,	,
cord-279343-ybncwweg	65	32	Asn362	asn362	ADD
cord-279343-ybncwweg	65	33	and	and	CC
cord-279343-ybncwweg	65	34	Asn365	asn365	CD
cord-279343-ybncwweg	65	35	,	,	,
cord-279343-ybncwweg	65	36	moved	move	VBD
cord-279343-ybncwweg	65	37	4.0	4.0	CD
cord-279343-ybncwweg	65	38	Å	å	NN
cord-279343-ybncwweg	65	39	and	and	CC
cord-279343-ybncwweg	65	40	1.9	1.9	CD
cord-279343-ybncwweg	65	41	Å	å	NN
cord-279343-ybncwweg	65	42	,	,	,
cord-279343-ybncwweg	65	43	respectively	respectively	RB
cord-279343-ybncwweg	65	44	,	,	,
cord-279343-ybncwweg	65	45	compared	compare	VBN
cord-279343-ybncwweg	65	46	to	to	IN
cord-279343-ybncwweg	65	47	the	the	DT
cord-279343-ybncwweg	65	48	CRD	crd	NN
cord-279343-ybncwweg	65	49	-	-	HYPH
cord-279343-ybncwweg	65	50	only	only	JJ
cord-279343-ybncwweg	65	51	structure	structure	NN
cord-279343-ybncwweg	65	52	(	(	-LRB-
cord-279343-ybncwweg	65	53	1K9J	1k9j	CD
cord-279343-ybncwweg	65	54	)	)	-RRB-
cord-279343-ybncwweg	65	55	.	.	.
cord-279343-ybncwweg	66	1	The	the	DT
cord-279343-ybncwweg	66	2	movement	movement	NN
cord-279343-ybncwweg	66	3	of	of	IN
cord-279343-ybncwweg	66	4	Asn362	asn362	CD
cord-279343-ybncwweg	66	5	and	and	CC
cord-279343-ybncwweg	66	6	Asn365	Asn365	NFP
cord-279343-ybncwweg	66	7	effectively	effectively	RB
cord-279343-ybncwweg	66	8	disrupts	disrupt	VBZ
cord-279343-ybncwweg	66	9	the	the	DT
cord-279343-ybncwweg	66	10	coordination	coordination	NN
cord-279343-ybncwweg	66	11	of	of	IN
cord-279343-ybncwweg	66	12	Ca1	ca1	NN
cord-279343-ybncwweg	66	13	and	and	CC
cord-279343-ybncwweg	66	14	Ca3	ca3	NN
cord-279343-ybncwweg	66	15	,	,	,
cord-279343-ybncwweg	66	16	further	further	JJ
cord-279343-ybncwweg	66	17	evidence	evidence	NN
cord-279343-ybncwweg	66	18	that	that	IN
cord-279343-ybncwweg	66	19	both	both	DT
cord-279343-ybncwweg	66	20	auxiliary	auxiliary	JJ
cord-279343-ybncwweg	66	21	calcium	calcium	NN
cord-279343-ybncwweg	66	22	ions	ion	NNS
cord-279343-ybncwweg	66	23	are	be	VBP
cord-279343-ybncwweg	66	24	absent	absent	JJ
cord-279343-ybncwweg	66	25	from	from	IN
cord-279343-ybncwweg	66	26	the	the	DT
cord-279343-ybncwweg	66	27	DC	DC	NNP
cord-279343-ybncwweg	66	28	-	-	HYPH
cord-279343-ybncwweg	66	29	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	66	30	R8	R8	NNP
cord-279343-ybncwweg	66	31	structure	structure	NN
cord-279343-ybncwweg	66	32	.	.	.
cord-279343-ybncwweg	67	1	Despite	despite	IN
cord-279343-ybncwweg	67	2	the	the	DT
cord-279343-ybncwweg	67	3	presence	presence	NN
cord-279343-ybncwweg	67	4	of	of	IN
cord-279343-ybncwweg	67	5	mannose	mannose	NN
cord-279343-ybncwweg	67	6	in	in	IN
cord-279343-ybncwweg	67	7	the	the	DT
cord-279343-ybncwweg	67	8	crystallization	crystallization	NN
cord-279343-ybncwweg	67	9	buffer	buffer	NN
cord-279343-ybncwweg	67	10	and	and	CC
cord-279343-ybncwweg	67	11	the	the	DT
cord-279343-ybncwweg	67	12	existence	existence	NN
cord-279343-ybncwweg	67	13	of	of	IN
cord-279343-ybncwweg	67	14	additional	additional	JJ
cord-279343-ybncwweg	67	15	electron	electron	NN
cord-279343-ybncwweg	67	16	density	density	NN
cord-279343-ybncwweg	67	17	at	at	IN
cord-279343-ybncwweg	67	18	the	the	DT
cord-279343-ybncwweg	67	19	putative	putative	JJ
cord-279343-ybncwweg	67	20	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	67	21	-	-	HYPH
cord-279343-ybncwweg	67	22	binding	bind	VBG
cord-279343-ybncwweg	67	23	site	site	NN
cord-279343-ybncwweg	67	24	,	,	,
cord-279343-ybncwweg	67	25	attempts	attempt	VBZ
cord-279343-ybncwweg	67	26	to	to	TO
cord-279343-ybncwweg	67	27	fit	fit	VB
cord-279343-ybncwweg	67	28	mannose	mannose	NN
cord-279343-ybncwweg	67	29	were	be	VBD
cord-279343-ybncwweg	67	30	not	not	RB
cord-279343-ybncwweg	67	31	satisfactory	satisfactory	JJ
cord-279343-ybncwweg	67	32	,	,	,
cord-279343-ybncwweg	67	33	and	and	CC
cord-279343-ybncwweg	67	34	instead	instead	RB
cord-279343-ybncwweg	67	35	,	,	,
cord-279343-ybncwweg	67	36	water	water	NN
cord-279343-ybncwweg	67	37	molecules	molecule	NNS
cord-279343-ybncwweg	67	38	were	be	VBD
cord-279343-ybncwweg	67	39	built	build	VBN
cord-279343-ybncwweg	67	40	throughout	throughout	IN
cord-279343-ybncwweg	67	41	the	the	DT
cord-279343-ybncwweg	67	42	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	67	43	-	-	HYPH
cord-279343-ybncwweg	67	44	binding	bind	VBG
cord-279343-ybncwweg	67	45	site	site	NN
cord-279343-ybncwweg	67	46	.	.	.
cord-279343-ybncwweg	68	1	The	the	DT
cord-279343-ybncwweg	68	2	comparison	comparison	NN
cord-279343-ybncwweg	68	3	between	between	IN
cord-279343-ybncwweg	68	4	the	the	DT
cord-279343-ybncwweg	68	5	current	current	JJ
cord-279343-ybncwweg	68	6	apo	apo	NNP
cord-279343-ybncwweg	68	7	-	-	HYPH
cord-279343-ybncwweg	68	8	DC	DC	NNP
cord-279343-ybncwweg	68	9	-	-	HYPH
cord-279343-ybncwweg	68	10	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	68	11	R8	R8	NNP
cord-279343-ybncwweg	68	12	and	and	CC
cord-279343-ybncwweg	68	13	the	the	DT
cord-279343-ybncwweg	68	14	mannose	mannose	NN
cord-279343-ybncwweg	68	15	-	-	HYPH
cord-279343-ybncwweg	68	16	containing	contain	VBG
cord-279343-ybncwweg	68	17	CRD	crd	NN
cord-279343-ybncwweg	68	18	structure	structure	NN
cord-279343-ybncwweg	68	19	showed	show	VBD
cord-279343-ybncwweg	68	20	both	both	CC
cord-279343-ybncwweg	68	21	the	the	DT
cord-279343-ybncwweg	68	22	primary	primary	JJ
cord-279343-ybncwweg	68	23	calcium	calcium	NN
cord-279343-ybncwweg	68	24	/	/	SYM
cord-279343-ybncwweg	68	25	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	68	26	-	-	HYPH
cord-279343-ybncwweg	68	27	binding	bind	VBG
cord-279343-ybncwweg	68	28	loop	loop	NN
cord-279343-ybncwweg	68	29	(	(	-LRB-
cord-279343-ybncwweg	68	30	residues	residue	NNS
cord-279343-ybncwweg	68	31	361	361	CD
cord-279343-ybncwweg	68	32	-	-	SYM
cord-279343-ybncwweg	68	33	366	366	CD
cord-279343-ybncwweg	68	34	)	)	-RRB-
cord-279343-ybncwweg	68	35	and	and	CC
cord-279343-ybncwweg	68	36	the	the	DT
cord-279343-ybncwweg	68	37	secondary	secondary	JJ
cord-279343-ybncwweg	68	38	calcium	calcium	NN
cord-279343-ybncwweg	68	39	-	-	HYPH
cord-279343-ybncwweg	68	40	binding	bind	VBG
cord-279343-ybncwweg	68	41	loop	loop	NN
cord-279343-ybncwweg	68	42	(	(	-LRB-
cord-279343-ybncwweg	68	43	residues	residue	NNS
cord-279343-ybncwweg	68	44	332	332	CD
cord-279343-ybncwweg	68	45	-	-	SYM
cord-279343-ybncwweg	68	46	339	339	CD
cord-279343-ybncwweg	68	47	)	)	-RRB-
cord-279343-ybncwweg	68	48	assumed	assume	VBD
cord-279343-ybncwweg	68	49	an	an	DT
cord-279343-ybncwweg	68	50	"	"	``
cord-279343-ybncwweg	68	51	open	open	JJ
cord-279343-ybncwweg	68	52	"	"	''
cord-279343-ybncwweg	68	53	conformation	conformation	NN
cord-279343-ybncwweg	68	54	in	in	IN
cord-279343-ybncwweg	68	55	the	the	DT
cord-279343-ybncwweg	68	56	apo	apo	NNP
cord-279343-ybncwweg	68	57	state	state	NN
cord-279343-ybncwweg	68	58	while	while	IN
cord-279343-ybncwweg	68	59	adopting	adopt	VBG
cord-279343-ybncwweg	68	60	a	a	DT
cord-279343-ybncwweg	68	61	"	"	``
cord-279343-ybncwweg	68	62	closed	closed	JJ
cord-279343-ybncwweg	68	63	"	"	''
cord-279343-ybncwweg	68	64	conformation	conformation	NN
cord-279343-ybncwweg	68	65	in	in	IN
cord-279343-ybncwweg	68	66	the	the	DT
cord-279343-ybncwweg	68	67	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	68	68	-	-	HYPH
cord-279343-ybncwweg	68	69	bound	bind	VBN
cord-279343-ybncwweg	68	70	state	state	NN
cord-279343-ybncwweg	68	71	of	of	IN
cord-279343-ybncwweg	68	72	the	the	DT
cord-279343-ybncwweg	68	73	receptor	receptor	NN
cord-279343-ybncwweg	68	74	(	(	-LRB-
cord-279343-ybncwweg	68	75	Figure	figure	NN
cord-279343-ybncwweg	68	76	2	2	CD
cord-279343-ybncwweg	68	77	)	)	-RRB-
cord-279343-ybncwweg	68	78	.	.	.
cord-279343-ybncwweg	69	1	In	in	IN
cord-279343-ybncwweg	69	2	the	the	DT
cord-279343-ybncwweg	69	3	presence	presence	NN
cord-279343-ybncwweg	69	4	of	of	IN
cord-279343-ybncwweg	69	5	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	69	6	,	,	,
cord-279343-ybncwweg	69	7	the	the	DT
cord-279343-ybncwweg	69	8	conformation	conformation	NN
cord-279343-ybncwweg	69	9	of	of	IN
cord-279343-ybncwweg	69	10	the	the	DT
cord-279343-ybncwweg	69	11	primary	primary	JJ
cord-279343-ybncwweg	69	12	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	69	13	-	-	HYPH
cord-279343-ybncwweg	69	14	binding	bind	VBG
cord-279343-ybncwweg	69	15	loop	loop	NN
cord-279343-ybncwweg	69	16	(	(	-LRB-
cord-279343-ybncwweg	69	17	residues	residue	NNS
cord-279343-ybncwweg	69	18	361	361	CD
cord-279343-ybncwweg	69	19	-	-	SYM
cord-279343-ybncwweg	69	20	366	366	CD
cord-279343-ybncwweg	69	21	)	)	-RRB-
cord-279343-ybncwweg	69	22	,	,	,
cord-279343-ybncwweg	69	23	the	the	DT
cord-279343-ybncwweg	69	24	closed	closed	JJ
cord-279343-ybncwweg	69	25	conformation	conformation	NN
cord-279343-ybncwweg	69	26	,	,	,
cord-279343-ybncwweg	69	27	is	be	VBZ
cord-279343-ybncwweg	69	28	defined	define	VBN
cord-279343-ybncwweg	69	29	by	by	IN
cord-279343-ybncwweg	69	30	the	the	DT
cord-279343-ybncwweg	69	31	coordinating	coordinate	VBG
cord-279343-ybncwweg	69	32	hydrogen	hydrogen	NN
cord-279343-ybncwweg	69	33	bonds	bond	NNS
cord-279343-ybncwweg	69	34	between	between	IN
cord-279343-ybncwweg	69	35	the	the	DT
cord-279343-ybncwweg	69	36	sidechains	sidechain	NNS
cord-279343-ybncwweg	69	37	of	of	IN
cord-279343-ybncwweg	69	38	Asn361	asn361	CD
cord-279343-ybncwweg	69	39	and	and	CC
cord-279343-ybncwweg	69	40	Ser363	ser363	CD
cord-279343-ybncwweg	69	41	,	,	,
cord-279343-ybncwweg	69	42	and	and	CC
cord-279343-ybncwweg	69	43	the	the	DT
cord-279343-ybncwweg	69	44	bound	bind	VBN
cord-279343-ybncwweg	69	45	N	n	NN
cord-279343-ybncwweg	69	46	-	-	HYPH
cord-279343-ybncwweg	69	47	acetyl	acetyl	NN
cord-279343-ybncwweg	69	48	-	-	HYPH
cord-279343-ybncwweg	69	49	D	d	NN
cord-279343-ybncwweg	69	50	-	-	HYPH
cord-279343-ybncwweg	69	51	glucosamine	glucosamine	JJ
cord-279343-ybncwweg	69	52	(	(	-LRB-
cord-279343-ybncwweg	69	53	GlcNAc1	glcnac1	NN
cord-279343-ybncwweg	69	54	)	)	-RRB-
cord-279343-ybncwweg	69	55	as	as	RB
cord-279343-ybncwweg	69	56	well	well	RB
cord-279343-ybncwweg	69	57	as	as	IN
cord-279343-ybncwweg	69	58	between	between	IN
cord-279343-ybncwweg	69	59	Asn362	asn362	CD
cord-279343-ybncwweg	69	60	and	and	CC
cord-279343-ybncwweg	69	61	Asn365	asn365	CD
cord-279343-ybncwweg	69	62	,	,	,
cord-279343-ybncwweg	69	63	and	and	CC
cord-279343-ybncwweg	69	64	their	-PRON-	PRP$
cord-279343-ybncwweg	69	65	bound	bind	VBN
cord-279343-ybncwweg	69	66	Ca1	ca1	NN
cord-279343-ybncwweg	69	67	and	and	CC
cord-279343-ybncwweg	69	68	Ca3	ca3	NN
cord-279343-ybncwweg	69	69	.	.	.
cord-279343-ybncwweg	70	1	In	in	IN
cord-279343-ybncwweg	70	2	the	the	DT
cord-279343-ybncwweg	70	3	absence	absence	NN
cord-279343-ybncwweg	70	4	of	of	IN
cord-279343-ybncwweg	70	5	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	70	6	,	,	,
cord-279343-ybncwweg	70	7	however	however	RB
cord-279343-ybncwweg	70	8	,	,	,
cord-279343-ybncwweg	70	9	(	(	-LRB-
cord-279343-ybncwweg	70	10	Table	table	NN
cord-279343-ybncwweg	70	11	2	2	CD
cord-279343-ybncwweg	70	12	and	and	CC
cord-279343-ybncwweg	70	13	Figure	figure	NN
cord-279343-ybncwweg	70	14	2	2	CD
cord-279343-ybncwweg	70	15	)	)	-RRB-
cord-279343-ybncwweg	70	16	.	.	.
cord-279343-ybncwweg	71	1	Interestingly	interestingly	RB
cord-279343-ybncwweg	71	2	,	,	,
cord-279343-ybncwweg	71	3	an	an	DT
cord-279343-ybncwweg	71	4	arginine	arginine	NN
cord-279343-ybncwweg	71	5	residue	residue	NN
cord-279343-ybncwweg	71	6	from	from	IN
cord-279343-ybncwweg	71	7	a	a	DT
cord-279343-ybncwweg	71	8	symmetry	symmetry	NN
cord-279343-ybncwweg	71	9	-	-	HYPH
cord-279343-ybncwweg	71	10	related	relate	VBN
cord-279343-ybncwweg	71	11	molecule	molecule	NN
cord-279343-ybncwweg	71	12	,	,	,
cord-279343-ybncwweg	71	13	Arg397	arg397	UH
cord-279343-ybncwweg	71	14	,	,	,
cord-279343-ybncwweg	71	15	is	be	VBZ
cord-279343-ybncwweg	71	16	found	find	VBN
cord-279343-ybncwweg	71	17	near	near	IN
cord-279343-ybncwweg	71	18	the	the	DT
cord-279343-ybncwweg	71	19	putative	putative	JJ
cord-279343-ybncwweg	71	20	Ca1	ca1	NN
cord-279343-ybncwweg	71	21	and	and	CC
cord-279343-ybncwweg	71	22	Ca3	ca3	NN
cord-279343-ybncwweg	71	23	sites	site	NNS
cord-279343-ybncwweg	71	24	,	,	,
cord-279343-ybncwweg	71	25	forming	form	VBG
cord-279343-ybncwweg	71	26	a	a	DT
cord-279343-ybncwweg	71	27	hydrogen	hydrogen	NN
cord-279343-ybncwweg	71	28	bond	bond	NN
cord-279343-ybncwweg	71	29	with	with	IN
cord-279343-ybncwweg	71	30	the	the	DT
cord-279343-ybncwweg	71	31	secondary	secondary	JJ
cord-279343-ybncwweg	71	32	calciumbinding	calciumbinding	NN
cord-279343-ybncwweg	71	33	loop	loop	NN
cord-279343-ybncwweg	71	34	to	to	TO
cord-279343-ybncwweg	71	35	neutralize	neutralize	VB
cord-279343-ybncwweg	71	36	,	,	,
cord-279343-ybncwweg	71	37	as	as	IN
cord-279343-ybncwweg	71	38	a	a	DT
cord-279343-ybncwweg	71	39	surrogate	surrogate	NN
cord-279343-ybncwweg	71	40	to	to	IN
cord-279343-ybncwweg	71	41	the	the	DT
cord-279343-ybncwweg	71	42	missing	miss	VBG
cord-279343-ybncwweg	71	43	calcium	calcium	NN
cord-279343-ybncwweg	71	44	ion	ion	NN
cord-279343-ybncwweg	71	45	,	,	,
cord-279343-ybncwweg	71	46	the	the	DT
cord-279343-ybncwweg	71	47	partial	partial	JJ
cord-279343-ybncwweg	71	48	negative	negative	JJ
cord-279343-ybncwweg	71	49	charges	charge	NNS
cord-279343-ybncwweg	71	50	of	of	IN
cord-279343-ybncwweg	71	51	the	the	DT
cord-279343-ybncwweg	71	52	region	region	NN
cord-279343-ybncwweg	71	53	.	.	.
cord-279343-ybncwweg	72	1	Despite	despite	IN
cord-279343-ybncwweg	72	2	the	the	DT
cord-279343-ybncwweg	72	3	presence	presence	NN
cord-279343-ybncwweg	72	4	of	of	IN
cord-279343-ybncwweg	72	5	5	5	CD
cord-279343-ybncwweg	72	6	mM	mm	CD
cord-279343-ybncwweg	72	7	CaCl	CaCl	NNP
cord-279343-ybncwweg	72	8	2	2	CD
cord-279343-ybncwweg	72	9	in	in	IN
cord-279343-ybncwweg	72	10	the	the	DT
cord-279343-ybncwweg	72	11	crystallization	crystallization	NN
cord-279343-ybncwweg	72	12	setup	setup	NN
cord-279343-ybncwweg	72	13	,	,	,
cord-279343-ybncwweg	72	14	both	both	CC
cord-279343-ybncwweg	72	15	Ca1	ca1	NN
cord-279343-ybncwweg	72	16	and	and	CC
cord-279343-ybncwweg	72	17	Ca3	ca3	NN
cord-279343-ybncwweg	72	18	appear	appear	VB
cord-279343-ybncwweg	72	19	to	to	TO
cord-279343-ybncwweg	72	20	be	be	VB
cord-279343-ybncwweg	72	21	absent	absent	JJ
cord-279343-ybncwweg	72	22	,	,	,
cord-279343-ybncwweg	72	23	suggesting	suggest	VBG
cord-279343-ybncwweg	72	24	that	that	IN
cord-279343-ybncwweg	72	25	these	these	DT
cord-279343-ybncwweg	72	26	auxiliary	auxiliary	JJ
cord-279343-ybncwweg	72	27	calcium	calcium	NN
cord-279343-ybncwweg	72	28	sites	site	NNS
cord-279343-ybncwweg	72	29	are	be	VBP
cord-279343-ybncwweg	72	30	of	of	IN
cord-279343-ybncwweg	72	31	low	low	JJ
cord-279343-ybncwweg	72	32	affinity	affinity	NN
cord-279343-ybncwweg	72	33	compared	compare	VBN
cord-279343-ybncwweg	72	34	to	to	IN
cord-279343-ybncwweg	72	35	that	that	DT
cord-279343-ybncwweg	72	36	of	of	IN
cord-279343-ybncwweg	72	37	the	the	DT
cord-279343-ybncwweg	72	38	primary	primary	JJ
cord-279343-ybncwweg	72	39	calcium	calcium	NN
cord-279343-ybncwweg	72	40	-	-	HYPH
cord-279343-ybncwweg	72	41	binding	bind	VBG
cord-279343-ybncwweg	72	42	site	site	NN
cord-279343-ybncwweg	72	43	(	(	-LRB-
cord-279343-ybncwweg	72	44	Ca2	Ca2	NNP
cord-279343-ybncwweg	72	45	)	)	-RRB-
cord-279343-ybncwweg	72	46	,	,	,
cord-279343-ybncwweg	72	47	and	and	CC
cord-279343-ybncwweg	72	48	that	that	IN
cord-279343-ybncwweg	72	49	their	-PRON-	PRP$
cord-279343-ybncwweg	72	50	occupancies	occupancy	NNS
cord-279343-ybncwweg	72	51	are	be	VBP
cord-279343-ybncwweg	72	52	coupled	couple	VBN
cord-279343-ybncwweg	72	53	to	to	IN
cord-279343-ybncwweg	72	54	the	the	DT
cord-279343-ybncwweg	72	55	binding	binding	NN
cord-279343-ybncwweg	72	56	of	of	IN
cord-279343-ybncwweg	72	57	the	the	DT
cord-279343-ybncwweg	72	58	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	72	59	ligand	ligand	NN
cord-279343-ybncwweg	72	60	.	.	.
cord-279343-ybncwweg	73	1	Namely	namely	RB
cord-279343-ybncwweg	73	2	,	,	,
cord-279343-ybncwweg	73	3	they	-PRON-	PRP
cord-279343-ybncwweg	73	4	are	be	VBP
cord-279343-ybncwweg	73	5	glycaninduced	glycaninduce	VBN
cord-279343-ybncwweg	73	6	calcium	calcium	NN
cord-279343-ybncwweg	73	7	-	-	HYPH
cord-279343-ybncwweg	73	8	binding	bind	VBG
cord-279343-ybncwweg	73	9	sites	site	NNS
cord-279343-ybncwweg	73	10	.	.	.
cord-279343-ybncwweg	74	1	In	in	IN
cord-279343-ybncwweg	74	2	the	the	DT
cord-279343-ybncwweg	74	3	absence	absence	NN
cord-279343-ybncwweg	74	4	of	of	IN
cord-279343-ybncwweg	74	5	the	the	DT
cord-279343-ybncwweg	74	6	bound	bind	VBN
cord-279343-ybncwweg	74	7	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	74	8	,	,	,
cord-279343-ybncwweg	74	9	both	both	DT
cord-279343-ybncwweg	74	10	calcium	calcium	NN
cord-279343-ybncwweg	74	11	coordination	coordination	NN
cord-279343-ybncwweg	74	12	loops	loop	NNS
cord-279343-ybncwweg	74	13	adopt	adopt	VBP
cord-279343-ybncwweg	74	14	an	an	DT
cord-279343-ybncwweg	74	15	open	open	JJ
cord-279343-ybncwweg	74	16	,	,	,
cord-279343-ybncwweg	74	17	conformation	conformation	NN
cord-279343-ybncwweg	74	18	ejecting	eject	VBG
cord-279343-ybncwweg	74	19	the	the	DT
cord-279343-ybncwweg	74	20	auxiliary	auxiliary	JJ
cord-279343-ybncwweg	74	21	calcium	calcium	NN
cord-279343-ybncwweg	74	22	ions	ion	NNS
cord-279343-ybncwweg	74	23	and	and	CC
cord-279343-ybncwweg	74	24	become	become	VBP
cord-279343-ybncwweg	74	25	less	less	RBR
cord-279343-ybncwweg	74	26	ordered	order	VBN
cord-279343-ybncwweg	74	27	.	.	.
cord-279343-ybncwweg	75	1	The	the	DT
cord-279343-ybncwweg	75	2	result	result	NN
cord-279343-ybncwweg	75	3	suggests	suggest	VBZ
cord-279343-ybncwweg	75	4	the	the	DT
cord-279343-ybncwweg	75	5	function	function	NN
cord-279343-ybncwweg	75	6	of	of	IN
cord-279343-ybncwweg	75	7	these	these	DT
cord-279343-ybncwweg	75	8	glycaninduced	glycaninduce	VBN
cord-279343-ybncwweg	75	9	auxiliary	auxiliary	JJ
cord-279343-ybncwweg	75	10	calcium	calcium	NN
cord-279343-ybncwweg	75	11	is	be	VBZ
cord-279343-ybncwweg	75	12	to	to	TO
cord-279343-ybncwweg	75	13	stabilize	stabilize	VB
cord-279343-ybncwweg	75	14	the	the	DT
cord-279343-ybncwweg	75	15	conformation	conformation	NN
cord-279343-ybncwweg	75	16	of	of	IN
cord-279343-ybncwweg	75	17	the	the	DT
cord-279343-ybncwweg	75	18	glycan	glycan	NN
cord-279343-ybncwweg	75	19	-	-	HYPH
cord-279343-ybncwweg	75	20	binding	bind	VBG
cord-279343-ybncwweg	75	21	loops	loop	NNS
cord-279343-ybncwweg	75	22	synergistically	synergistically	RB
cord-279343-ybncwweg	75	23	to	to	IN
cord-279343-ybncwweg	75	24	the	the	DT
cord-279343-ybncwweg	75	25	bound	bind	VBN
cord-279343-ybncwweg	75	26	glycan	glycan	NN
cord-279343-ybncwweg	75	27	rather	rather	RB
cord-279343-ybncwweg	75	28	than	than	IN
cord-279343-ybncwweg	75	29	to	to	TO
cord-279343-ybncwweg	75	30	preconform	preconform	VB
cord-279343-ybncwweg	75	31	the	the	DT
cord-279343-ybncwweg	75	32	glycan	glycan	NN
cord-279343-ybncwweg	75	33	-	-	HYPH
cord-279343-ybncwweg	75	34	binding	bind	VBG
cord-279343-ybncwweg	75	35	loop	loop	NN
cord-279343-ybncwweg	75	36	.	.	.
cord-279343-ybncwweg	76	1	[	[	-LRB-
cord-279343-ybncwweg	76	2	23	23	CD
cord-279343-ybncwweg	76	3	]	]	-RRB-
cord-279343-ybncwweg	76	4	[	[	-LRB-
cord-279343-ybncwweg	76	5	24	24	CD
cord-279343-ybncwweg	76	6	]	]	-RRB-
cord-279343-ybncwweg	76	7	[	[	-LRB-
cord-279343-ybncwweg	76	8	25	25	CD
cord-279343-ybncwweg	76	9	]	]	-RRB-
cord-279343-ybncwweg	77	1	Modeling	model	VBG
cord-279343-ybncwweg	77	2	of	of	IN
cord-279343-ybncwweg	77	3	the	the	DT
cord-279343-ybncwweg	77	4	DC	DC	NNP
cord-279343-ybncwweg	77	5	-	-	HYPH
cord-279343-ybncwweg	77	6	SIGN	SIGN	NNP
cord-279343-ybncwweg	77	7	/	/	SYM
cord-279343-ybncwweg	77	8	R	r	NN
cord-279343-ybncwweg	77	9	tetramer	tetramer	NN
cord-279343-ybncwweg	78	1	A	a	DT
cord-279343-ybncwweg	78	2	homology	homology	NN
cord-279343-ybncwweg	78	3	search	search	NN
cord-279343-ybncwweg	78	4	was	be	VBD
cord-279343-ybncwweg	78	5	performed	perform	VBN
cord-279343-ybncwweg	78	6	using	use	VBG
cord-279343-ybncwweg	78	7	sequences	sequence	NNS
cord-279343-ybncwweg	78	8	corresponding	correspond	VBG
cord-279343-ybncwweg	78	9	to	to	IN
cord-279343-ybncwweg	78	10	various	various	JJ
cord-279343-ybncwweg	78	11	lengths	length	NNS
cord-279343-ybncwweg	78	12	of	of	IN
cord-279343-ybncwweg	78	13	the	the	DT
cord-279343-ybncwweg	78	14	repeat	repeat	NN
cord-279343-ybncwweg	78	15	domain	domain	NN
cord-279343-ybncwweg	78	16	of	of	IN
cord-279343-ybncwweg	78	17	DC	DC	NNP
cord-279343-ybncwweg	78	18	-	-	HYPH
cord-279343-ybncwweg	78	19	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	78	20	against	against	IN
cord-279343-ybncwweg	78	21	known	know	VBN
cord-279343-ybncwweg	78	22	structures	structure	NNS
cord-279343-ybncwweg	78	23	in	in	IN
cord-279343-ybncwweg	78	24	the	the	DT
cord-279343-ybncwweg	78	25	Protein	Protein	NNP
cord-279343-ybncwweg	78	26	Data	Data	NNP
cord-279343-ybncwweg	78	27	Bank	Bank	NNP
cord-279343-ybncwweg	78	28	(	(	-LRB-
cord-279343-ybncwweg	78	29	PDB	PDB	NNP
cord-279343-ybncwweg	78	30	)	)	-RRB-
cord-279343-ybncwweg	78	31	.	.	.
cord-279343-ybncwweg	79	1	The	the	DT
cord-279343-ybncwweg	79	2	resulting	result	VBG
cord-279343-ybncwweg	79	3	sequence	sequence	NN
cord-279343-ybncwweg	79	4	identities	identity	NNS
cord-279343-ybncwweg	79	5	between	between	IN
cord-279343-ybncwweg	79	6	segments	segment	NNS
cord-279343-ybncwweg	79	7	of	of	IN
cord-279343-ybncwweg	79	8	known	know	VBN
cord-279343-ybncwweg	79	9	structures	structure	NNS
cord-279343-ybncwweg	79	10	and	and	CC
cord-279343-ybncwweg	79	11	portions	portion	NNS
cord-279343-ybncwweg	79	12	of	of	IN
cord-279343-ybncwweg	79	13	DC	DC	NNP
cord-279343-ybncwweg	79	14	-	-	HYPH
cord-279343-ybncwweg	79	15	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	79	16	repeats	repeat	VBZ
cord-279343-ybncwweg	79	17	are	be	VBP
cord-279343-ybncwweg	79	18	32	32	CD
cord-279343-ybncwweg	79	19	%	%	NN
cord-279343-ybncwweg	79	20	between	between	IN
cord-279343-ybncwweg	79	21	residues	residue	NNS
cord-279343-ybncwweg	79	22	32	32	CD
cord-279343-ybncwweg	79	23	-	-	SYM
cord-279343-ybncwweg	79	24	117	117	CD
cord-279343-ybncwweg	79	25	of	of	IN
cord-279343-ybncwweg	79	26	the	the	DT
cord-279343-ybncwweg	79	27	focal	focal	JJ
cord-279343-ybncwweg	79	28	adhesion	adhesion	NN
cord-279343-ybncwweg	79	29	kinase	kinase	NN
cord-279343-ybncwweg	79	30	(	(	-LRB-
cord-279343-ybncwweg	79	31	PDB	PDB	NNP
cord-279343-ybncwweg	79	32	code	code	NN
cord-279343-ybncwweg	79	33	1K05	1k05	CD
cord-279343-ybncwweg	79	34	)	)	-RRB-
cord-279343-ybncwweg	79	35	and	and	CC
cord-279343-ybncwweg	79	36	repeats	repeat	VBZ
cord-279343-ybncwweg	79	37	R1-R3	R1-R3	NNP
cord-279343-ybncwweg	79	38	of	of	IN
cord-279343-ybncwweg	79	39	DC	DC	NNP
cord-279343-ybncwweg	79	40	-	-	HYPH
cord-279343-ybncwweg	79	41	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	79	42	(	(	-LRB-
cord-279343-ybncwweg	79	43	Figure	Figure	NNP
cord-279343-ybncwweg	79	44	3	3	CD
cord-279343-ybncwweg	79	45	)	)	-RRB-
cord-279343-ybncwweg	79	46	,	,	,
cord-279343-ybncwweg	79	47	31	31	CD
cord-279343-ybncwweg	79	48	%	%	NN
cord-279343-ybncwweg	79	49	between	between	IN
cord-279343-ybncwweg	79	50	residues	residue	NNS
cord-279343-ybncwweg	79	51	328	328	CD
cord-279343-ybncwweg	79	52	-	-	SYM
cord-279343-ybncwweg	79	53	390	390	CD
cord-279343-ybncwweg	79	54	of	of	IN
cord-279343-ybncwweg	79	55	Muts	Muts	NNP
cord-279343-ybncwweg	79	56	(	(	-LRB-
cord-279343-ybncwweg	79	57	PDB	PDB	NNP
cord-279343-ybncwweg	79	58	code	code	NN
cord-279343-ybncwweg	79	59	1NNE	1nne	CD
cord-279343-ybncwweg	79	60	)	)	-RRB-
cord-279343-ybncwweg	79	61	and	and	CC
cord-279343-ybncwweg	79	62	repeats	repeat	VBZ
cord-279343-ybncwweg	79	63	R5-R7	R5-R7	NNP
cord-279343-ybncwweg	79	64	,	,	,
cord-279343-ybncwweg	79	65	33	33	CD
cord-279343-ybncwweg	79	66	%	%	NN
cord-279343-ybncwweg	79	67	between	between	IN
cord-279343-ybncwweg	79	68	residues	residue	NNS
cord-279343-ybncwweg	79	69	23	23	CD
cord-279343-ybncwweg	79	70	-	-	SYM
cord-279343-ybncwweg	79	71	67	67	CD
cord-279343-ybncwweg	79	72	of	of	IN
cord-279343-ybncwweg	79	73	the	the	DT
cord-279343-ybncwweg	79	74	large	large	JJ
cord-279343-ybncwweg	79	75	ribosomal	ribosomal	JJ
cord-279343-ybncwweg	79	76	subunit	subunit	NN
cord-279343-ybncwweg	79	77	from	from	IN
cord-279343-ybncwweg	79	78	Deinococcus	Deinococcus	NNP
cord-279343-ybncwweg	79	79	radiodurans	radioduran	NNS
cord-279343-ybncwweg	79	80	(	(	-LRB-
cord-279343-ybncwweg	79	81	PDB	PDB	NNP
cord-279343-ybncwweg	79	82	code	code	NN
cord-279343-ybncwweg	79	83	1NKW	1nkw	CD
cord-279343-ybncwweg	79	84	)	)	-RRB-
cord-279343-ybncwweg	79	85	and	and	CC
cord-279343-ybncwweg	79	86	repeats	repeat	VBZ
cord-279343-ybncwweg	79	87	R6	R6	NNP
cord-279343-ybncwweg	79	88	and	and	CC
cord-279343-ybncwweg	79	89	R7	R7	NNP
cord-279343-ybncwweg	79	90	,	,	,
cord-279343-ybncwweg	79	91	37	37	CD
cord-279343-ybncwweg	79	92	%	%	NN
cord-279343-ybncwweg	79	93	between	between	IN
cord-279343-ybncwweg	79	94	residues	residue	NNS
cord-279343-ybncwweg	79	95	60	60	CD
cord-279343-ybncwweg	79	96	-	-	SYM
cord-279343-ybncwweg	79	97	106	106	CD
cord-279343-ybncwweg	79	98	of	of	IN
cord-279343-ybncwweg	79	99	the	the	DT
cord-279343-ybncwweg	79	100	monomeric	monomeric	JJ
cord-279343-ybncwweg	79	101	isocitrate	isocitrate	NN
cord-279343-ybncwweg	79	102	dehydrogenase	dehydrogenase	NN
cord-279343-ybncwweg	79	103	(	(	-LRB-
cord-279343-ybncwweg	79	104	PDB	PDB	NNP
cord-279343-ybncwweg	79	105	code	code	NN
cord-279343-ybncwweg	79	106	1ITW	1itw	CD
cord-279343-ybncwweg	79	107	)	)	-RRB-
cord-279343-ybncwweg	79	108	and	and	CC
cord-279343-ybncwweg	79	109	repeats	repeat	VBZ
cord-279343-ybncwweg	79	110	R6-R8	R6-R8	NNP
cord-279343-ybncwweg	79	111	.	.	.
cord-279343-ybncwweg	80	1	All	all	DT
cord-279343-ybncwweg	80	2	homologous	homologous	JJ
cord-279343-ybncwweg	80	3	structures	structure	NNS
cord-279343-ybncwweg	80	4	are	be	VBP
cord-279343-ybncwweg	80	5	helical	helical	JJ
cord-279343-ybncwweg	80	6	in	in	IN
cord-279343-ybncwweg	80	7	nature	nature	NN
cord-279343-ybncwweg	80	8	.	.	.
cord-279343-ybncwweg	81	1	Both	both	DT
cord-279343-ybncwweg	81	2	homology	homology	NN
cord-279343-ybncwweg	81	3	modeling	modeling	NN
cord-279343-ybncwweg	81	4	and	and	CC
cord-279343-ybncwweg	81	5	sequence	sequence	NN
cord-279343-ybncwweg	81	6	-	-	HYPH
cord-279343-ybncwweg	81	7	based	base	VBN
cord-279343-ybncwweg	81	8	secondary	secondary	JJ
cord-279343-ybncwweg	81	9	structure	structure	NN
cord-279343-ybncwweg	81	10	prediction	prediction	NN
cord-279343-ybncwweg	81	11	resulted	result	VBD
cord-279343-ybncwweg	81	12	in	in	IN
cord-279343-ybncwweg	81	13	similar	similar	JJ
cord-279343-ybncwweg	81	14	secondary	secondary	JJ
cord-279343-ybncwweg	81	15	structure	structure	NN
cord-279343-ybncwweg	81	16	assignment	assignment	NN
cord-279343-ybncwweg	81	17	,	,	,
cord-279343-ybncwweg	81	18	including	include	VBG
cord-279343-ybncwweg	81	19	the	the	DT
cord-279343-ybncwweg	81	20	boundary	boundary	NN
cord-279343-ybncwweg	81	21	of	of	IN
cord-279343-ybncwweg	81	22	helices	helix	NNS
cord-279343-ybncwweg	81	23	,	,	,
cord-279343-ybncwweg	81	24	turns	turn	VBZ
cord-279343-ybncwweg	81	25	and	and	CC
cord-279343-ybncwweg	81	26	loops	loop	NNS
cord-279343-ybncwweg	81	27	throughout	throughout	IN
cord-279343-ybncwweg	81	28	the	the	DT
cord-279343-ybncwweg	81	29	R1-R8	R1-R8	NNPS
cord-279343-ybncwweg	81	30	repeat	repeat	NN
cord-279343-ybncwweg	81	31	domain	domain	NN
cord-279343-ybncwweg	81	32	of	of	IN
cord-279343-ybncwweg	81	33	DC	DC	NNP
cord-279343-ybncwweg	81	34	-	-	HYPH
cord-279343-ybncwweg	81	35	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	81	36	.	.	.
cord-279343-ybncwweg	82	1	Additional	additional	JJ
cord-279343-ybncwweg	82	2	structural	structural	JJ
cord-279343-ybncwweg	82	3	information	information	NN
cord-279343-ybncwweg	82	4	derived	derive	VBN
cord-279343-ybncwweg	82	5	from	from	IN
cord-279343-ybncwweg	82	6	gel	gel	NN
cord-279343-ybncwweg	82	7	-	-	HYPH
cord-279343-ybncwweg	82	8	filtration	filtration	NN
cord-279343-ybncwweg	82	9	experiments	experiment	NNS
cord-279343-ybncwweg	82	10	on	on	IN
cord-279343-ybncwweg	82	11	truncated	truncated	JJ
cord-279343-ybncwweg	82	12	receptors	receptor	NNS
cord-279343-ybncwweg	82	13	showing	show	VBG
cord-279343-ybncwweg	82	14	that	that	IN
cord-279343-ybncwweg	82	15	receptor	receptor	NN
cord-279343-ybncwweg	82	16	tetramerization	tetramerization	NN
cord-279343-ybncwweg	82	17	requires	require	VBZ
cord-279343-ybncwweg	82	18	R5-R8	R5-R8	NNP
cord-279343-ybncwweg	82	19	repeats	repeat	VBZ
cord-279343-ybncwweg	82	20	and	and	CC
cord-279343-ybncwweg	82	21	analytical	analytical	JJ
cord-279343-ybncwweg	82	22	ultracentrifugation	ultracentrifugation	NN
cord-279343-ybncwweg	82	23	observations	observation	NNS
cord-279343-ybncwweg	82	24	suggesting	suggest	VBG
cord-279343-ybncwweg	82	25	an	an	DT
cord-279343-ybncwweg	82	26	elongated	elongated	JJ
cord-279343-ybncwweg	82	27	shape	shape	NN
cord-279343-ybncwweg	82	28	of	of	IN
cord-279343-ybncwweg	82	29	the	the	DT
cord-279343-ybncwweg	82	30	tetramer	tetramer	NN
cord-279343-ybncwweg	82	31	were	be	VBD
cord-279343-ybncwweg	82	32	included	include	VBN
cord-279343-ybncwweg	82	33	in	in	IN
cord-279343-ybncwweg	82	34	the	the	DT
cord-279343-ybncwweg	82	35	modeling	modeling	NN
cord-279343-ybncwweg	82	36	of	of	IN
cord-279343-ybncwweg	82	37	the	the	DT
cord-279343-ybncwweg	82	38	tetramer	tetramer	NN
cord-279343-ybncwweg	82	39	.	.	.
cord-279343-ybncwweg	83	1	21	21	CD
cord-279343-ybncwweg	84	1	Based	base	VBN
cord-279343-ybncwweg	84	2	on	on	IN
cord-279343-ybncwweg	84	3	the	the	DT
cord-279343-ybncwweg	84	4	overlapping	overlap	VBG
cord-279343-ybncwweg	84	5	homologous	homologous	JJ
cord-279343-ybncwweg	84	6	structures	structure	NNS
cord-279343-ybncwweg	84	7	and	and	CC
cord-279343-ybncwweg	84	8	the	the	DT
cord-279343-ybncwweg	84	9	biophysical	biophysical	JJ
cord-279343-ybncwweg	84	10	shape	shape	NN
cord-279343-ybncwweg	84	11	consideration	consideration	NN
cord-279343-ybncwweg	84	12	and	and	CC
cord-279343-ybncwweg	84	13	using	use	VBG
cord-279343-ybncwweg	84	14	the	the	DT
cord-279343-ybncwweg	84	15	focal	focal	JJ
cord-279343-ybncwweg	84	16	adhesion	adhesion	NN
cord-279343-ybncwweg	84	17	kinase	kinase	NN
cord-279343-ybncwweg	84	18	(	(	-LRB-
cord-279343-ybncwweg	84	19	PDB	PDB	NNP
cord-279343-ybncwweg	84	20	code	code	NN
cord-279343-ybncwweg	84	21	1K05	1k05	CD
cord-279343-ybncwweg	84	22	)	)	-RRB-
cord-279343-ybncwweg	84	23	as	as	IN
cord-279343-ybncwweg	84	24	a	a	DT
cord-279343-ybncwweg	84	25	template	template	NN
cord-279343-ybncwweg	84	26	(	(	-LRB-
cord-279343-ybncwweg	84	27	Supplementary	Supplementary	NNP
cord-279343-ybncwweg	84	28	Data	Data	NNP
cord-279343-ybncwweg	84	29	Figure	Figure	NNP
cord-279343-ybncwweg	84	30	1	1	CD
cord-279343-ybncwweg	84	31	)	)	-RRB-
cord-279343-ybncwweg	84	32	,	,	,
cord-279343-ybncwweg	84	33	a	a	DT
cord-279343-ybncwweg	84	34	polyalanine	polyalanine	NN
cord-279343-ybncwweg	84	35	model	model	NN
cord-279343-ybncwweg	84	36	of	of	IN
cord-279343-ybncwweg	84	37	DC	DC	NNP
cord-279343-ybncwweg	84	38	-	-	HYPH
cord-279343-ybncwweg	84	39	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	84	40	tetramer	tetramer	NN
cord-279343-ybncwweg	84	41	was	be	VBD
cord-279343-ybncwweg	84	42	built	build	VBN
cord-279343-ybncwweg	84	43	manually	manually	RB
cord-279343-ybncwweg	84	44	using	use	VBG
cord-279343-ybncwweg	84	45	the	the	DT
cord-279343-ybncwweg	84	46	crystallographic	crystallographic	JJ
cord-279343-ybncwweg	84	47	program	program	NN
cord-279343-ybncwweg	84	48	O	o	NN
cord-279343-ybncwweg	84	49	and	and	CC
cord-279343-ybncwweg	84	50	subjected	subject	VBN
cord-279343-ybncwweg	84	51	to	to	IN
cord-279343-ybncwweg	84	52	energy	energy	NN
cord-279343-ybncwweg	84	53	minimization	minimization	NN
cord-279343-ybncwweg	84	54	using	use	VBG
cord-279343-ybncwweg	84	55	CNS	CNS	NNP
cord-279343-ybncwweg	84	56	(	(	-LRB-
cord-279343-ybncwweg	84	57	Figure	figure	NN
cord-279343-ybncwweg	84	58	4	4	CD
cord-279343-ybncwweg	84	59	)	)	-RRB-
cord-279343-ybncwweg	84	60	.	.	.
cord-279343-ybncwweg	85	1	The	the	DT
cord-279343-ybncwweg	85	2	tetramer	tetramer	NN
cord-279343-ybncwweg	85	3	model	model	NN
cord-279343-ybncwweg	85	4	displays	display	VBZ
cord-279343-ybncwweg	85	5	a	a	DT
cord-279343-ybncwweg	85	6	4-fold	4-fold	CD
cord-279343-ybncwweg	85	7	symmetry	symmetry	NN
cord-279343-ybncwweg	85	8	,	,	,
cord-279343-ybncwweg	85	9	with	with	IN
cord-279343-ybncwweg	85	10	the	the	DT
cord-279343-ybncwweg	85	11	core	core	NN
cord-279343-ybncwweg	85	12	tetramerization	tetramerization	NN
cord-279343-ybncwweg	85	13	domain	domain	NN
cord-279343-ybncwweg	85	14	adopting	adopt	VBG
cord-279343-ybncwweg	85	15	a	a	DT
cord-279343-ybncwweg	85	16	four	four	CD
cord-279343-ybncwweg	85	17	-	-	HYPH
cord-279343-ybncwweg	85	18	helix	helix	NN
cord-279343-ybncwweg	85	19	bundle	bundle	NN
cord-279343-ybncwweg	85	20	structure	structure	NN
cord-279343-ybncwweg	85	21	similar	similar	JJ
cord-279343-ybncwweg	85	22	to	to	IN
cord-279343-ybncwweg	85	23	that	that	DT
cord-279343-ybncwweg	85	24	of	of	IN
cord-279343-ybncwweg	85	25	the	the	DT
cord-279343-ybncwweg	85	26	focal	focal	JJ
cord-279343-ybncwweg	85	27	adhesion	adhesion	NN
cord-279343-ybncwweg	85	28	kinase	kinase	NN
cord-279343-ybncwweg	85	29	(	(	-LRB-
cord-279343-ybncwweg	85	30	see	see	VB
cord-279343-ybncwweg	85	31	Supplementary	Supplementary	NNP
cord-279343-ybncwweg	85	32	Data	Data	NNP
cord-279343-ybncwweg	85	33	for	for	IN
cord-279343-ybncwweg	85	34	a	a	DT
cord-279343-ybncwweg	85	35	more	more	RBR
cord-279343-ybncwweg	85	36	detailed	detailed	JJ
cord-279343-ybncwweg	85	37	description	description	NN
cord-279343-ybncwweg	85	38	of	of	IN
cord-279343-ybncwweg	85	39	the	the	DT
cord-279343-ybncwweg	85	40	model	model	NN
cord-279343-ybncwweg	85	41	)	)	-RRB-
cord-279343-ybncwweg	85	42	.	.	.
cord-279343-ybncwweg	86	1	The	the	DT
cord-279343-ybncwweg	86	2	arrangement	arrangement	NN
cord-279343-ybncwweg	86	3	of	of	IN
cord-279343-ybncwweg	86	4	the	the	DT
cord-279343-ybncwweg	86	5	R7	R7	NNP
cord-279343-ybncwweg	86	6	and	and	CC
cord-279343-ybncwweg	86	7	R8	R8	NNP
cord-279343-ybncwweg	86	8	helices	helix	NNS
cord-279343-ybncwweg	86	9	in	in	IN
cord-279343-ybncwweg	86	10	this	this	DT
cord-279343-ybncwweg	86	11	model	model	NN
cord-279343-ybncwweg	86	12	agree	agree	VBP
cord-279343-ybncwweg	86	13	with	with	IN
cord-279343-ybncwweg	86	14	the	the	DT
cord-279343-ybncwweg	86	15	recently	recently	RB
cord-279343-ybncwweg	86	16	deposited	deposit	VBN
cord-279343-ybncwweg	86	17	structure	structure	NN
cord-279343-ybncwweg	86	18	of	of	IN
cord-279343-ybncwweg	86	19	DC	DC	NNP
cord-279343-ybncwweg	86	20	-	-	HYPH
cord-279343-ybncwweg	86	21	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	86	22	containing	contain	VBG
cord-279343-ybncwweg	86	23	both	both	CC
cord-279343-ybncwweg	86	24	R7	R7	NNP
cord-279343-ybncwweg	86	25	and	and	CC
cord-279343-ybncwweg	86	26	R8	R8	NNP
cord-279343-ybncwweg	86	27	repeats	repeat	VBZ
cord-279343-ybncwweg	86	28	(	(	-LRB-
cord-279343-ybncwweg	87	1	PDB	PDB	NNP
cord-279343-ybncwweg	87	2	code	code	NN
cord-279343-ybncwweg	87	3	1SL6	1sl6	CD
cord-279343-ybncwweg	87	4	)	)	-RRB-
cord-279343-ybncwweg	87	5	.	.	.
cord-279343-ybncwweg	88	1	22	22	CD
cord-279343-ybncwweg	89	1	The	the	DT
cord-279343-ybncwweg	89	2	dimensions	dimension	NNS
cord-279343-ybncwweg	89	3	of	of	IN
cord-279343-ybncwweg	89	4	the	the	DT
cord-279343-ybncwweg	89	5	model	model	NN
cord-279343-ybncwweg	89	6	proposed	propose	VBN
cord-279343-ybncwweg	89	7	here	here	RB
cord-279343-ybncwweg	89	8	are	be	VBP
cord-279343-ybncwweg	89	9	w80	w80	NN
cord-279343-ybncwweg	89	10	Å	å	NN
cord-279343-ybncwweg	89	11	!	!	.
cord-279343-ybncwweg	89	12	80	80	CD
cord-279343-ybncwweg	89	13	Å	å	NN
cord-279343-ybncwweg	89	14	!	!	.
cord-279343-ybncwweg	89	15	190	190	CD
cord-279343-ybncwweg	89	16	Å	å	NN
cord-279343-ybncwweg	89	17	with	with	IN
cord-279343-ybncwweg	89	18	individual	individual	JJ
cord-279343-ybncwweg	89	19	CRD	crd	NN
cord-279343-ybncwweg	89	20	separated	separate	VBN
cord-279343-ybncwweg	89	21	by	by	IN
cord-279343-ybncwweg	89	22	w50	w50	NNP
cord-279343-ybncwweg	89	23	Å	Å	NNP
cord-279343-ybncwweg	89	24	.	.	.
cord-279343-ybncwweg	90	1	On	on	IN
cord-279343-ybncwweg	90	2	the	the	DT
cord-279343-ybncwweg	90	3	Table	table	NN
cord-279343-ybncwweg	90	4	2	2	CD
cord-279343-ybncwweg	90	5	.	.	.
cord-279343-ybncwweg	91	1	We	-PRON-	PRP
cord-279343-ybncwweg	91	2	carried	carry	VBD
cord-279343-ybncwweg	91	3	out	out	RP
cord-279343-ybncwweg	91	4	limited	limited	JJ
cord-279343-ybncwweg	91	5	proteolysis	proteolysis	NN
cord-279343-ybncwweg	91	6	using	use	VBG
cord-279343-ybncwweg	91	7	trypsin	trypsin	NN
cord-279343-ybncwweg	91	8	to	to	TO
cord-279343-ybncwweg	91	9	explore	explore	VB
cord-279343-ybncwweg	91	10	the	the	DT
cord-279343-ybncwweg	91	11	likelihood	likelihood	NN
cord-279343-ybncwweg	91	12	of	of	IN
cord-279343-ybncwweg	91	13	the	the	DT
cord-279343-ybncwweg	91	14	proposed	propose	VBN
cord-279343-ybncwweg	91	15	model	model	NN
cord-279343-ybncwweg	91	16	of	of	IN
cord-279343-ybncwweg	91	17	helical	helical	JJ
cord-279343-ybncwweg	91	18	repeat	repeat	NN
cord-279343-ybncwweg	91	19	bundles	bundle	NNS
cord-279343-ybncwweg	91	20	for	for	IN
cord-279343-ybncwweg	91	21	the	the	DT
cord-279343-ybncwweg	91	22	tetrameric	tetrameric	JJ
cord-279343-ybncwweg	91	23	DC	DC	NNP
cord-279343-ybncwweg	91	24	-	-	HYPH
cord-279343-ybncwweg	91	25	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	91	26	versus	versus	IN
cord-279343-ybncwweg	91	27	a	a	DT
cord-279343-ybncwweg	91	28	model	model	NN
cord-279343-ybncwweg	91	29	consisting	consist	VBG
cord-279343-ybncwweg	91	30	of	of	IN
cord-279343-ybncwweg	91	31	an	an	DT
cord-279343-ybncwweg	91	32	elongated	elongated	JJ
cord-279343-ybncwweg	91	33	linear	linear	JJ
cord-279343-ybncwweg	91	34	concatenation	concatenation	NN
cord-279343-ybncwweg	91	35	of	of	IN
cord-279343-ybncwweg	91	36	helical	helical	JJ
cord-279343-ybncwweg	91	37	repeats	repeat	NNS
cord-279343-ybncwweg	91	38	(	(	-LRB-
cord-279343-ybncwweg	91	39	Figure	figure	NN
cord-279343-ybncwweg	91	40	4	4	CD
cord-279343-ybncwweg	91	41	)	)	-RRB-
cord-279343-ybncwweg	91	42	.	.	.
cord-279343-ybncwweg	92	1	Since	since	IN
cord-279343-ybncwweg	92	2	identical	identical	JJ
cord-279343-ybncwweg	92	3	trypsin	trypsin	NN
cord-279343-ybncwweg	92	4	digestion	digestion	NN
cord-279343-ybncwweg	92	5	sites	site	NNS
cord-279343-ybncwweg	92	6	are	be	VBP
cord-279343-ybncwweg	92	7	found	find	VBN
cord-279343-ybncwweg	92	8	within	within	IN
cord-279343-ybncwweg	92	9	each	each	DT
cord-279343-ybncwweg	92	10	repeat	repeat	NN
cord-279343-ybncwweg	92	11	region	region	NN
cord-279343-ybncwweg	92	12	,	,	,
cord-279343-ybncwweg	92	13	a	a	DT
cord-279343-ybncwweg	92	14	differential	differential	JJ
cord-279343-ybncwweg	92	15	use	use	NN
cord-279343-ybncwweg	92	16	of	of	IN
cord-279343-ybncwweg	92	17	each	each	DT
cord-279343-ybncwweg	92	18	potential	potential	JJ
cord-279343-ybncwweg	92	19	trypsin	trypsin	NN
cord-279343-ybncwweg	92	20	site	site	NN
cord-279343-ybncwweg	92	21	would	would	MD
cord-279343-ybncwweg	92	22	suggest	suggest	VB
cord-279343-ybncwweg	92	23	differential	differential	JJ
cord-279343-ybncwweg	92	24	protection	protection	NN
cord-279343-ybncwweg	92	25	from	from	IN
cord-279343-ybncwweg	92	26	the	the	DT
cord-279343-ybncwweg	92	27	protease	protease	NN
cord-279343-ybncwweg	92	28	.	.	.
cord-279343-ybncwweg	93	1	The	the	DT
cord-279343-ybncwweg	93	2	tight	tight	JJ
cord-279343-ybncwweg	93	3	packing	packing	NN
cord-279343-ybncwweg	93	4	of	of	IN
cord-279343-ybncwweg	93	5	the	the	DT
cord-279343-ybncwweg	93	6	proposed	propose	VBN
cord-279343-ybncwweg	93	7	model	model	NN
cord-279343-ybncwweg	93	8	predicts	predict	VBZ
cord-279343-ybncwweg	93	9	a	a	DT
cord-279343-ybncwweg	93	10	biased	biased	JJ
cord-279343-ybncwweg	93	11	protease	protease	NN
cord-279343-ybncwweg	93	12	-	-	HYPH
cord-279343-ybncwweg	93	13	sensitivity	sensitivity	NN
cord-279343-ybncwweg	93	14	for	for	IN
cord-279343-ybncwweg	93	15	the	the	DT
cord-279343-ybncwweg	93	16	different	different	JJ
cord-279343-ybncwweg	93	17	repeats	repeat	NNS
cord-279343-ybncwweg	93	18	with	with	IN
cord-279343-ybncwweg	93	19	the	the	DT
cord-279343-ybncwweg	93	20	core	core	NN
cord-279343-ybncwweg	93	21	tetramer	tetramer	NN
cord-279343-ybncwweg	93	22	packing	packing	NN
cord-279343-ybncwweg	93	23	repeats	repeat	VBZ
cord-279343-ybncwweg	93	24	less	less	RBR
cord-279343-ybncwweg	93	25	accessible	accessible	JJ
cord-279343-ybncwweg	93	26	than	than	IN
cord-279343-ybncwweg	93	27	the	the	DT
cord-279343-ybncwweg	93	28	peripheral	peripheral	JJ
cord-279343-ybncwweg	93	29	repeats	repeat	NNS
cord-279343-ybncwweg	93	30	,	,	,
cord-279343-ybncwweg	93	31	while	while	IN
cord-279343-ybncwweg	93	32	the	the	DT
cord-279343-ybncwweg	93	33	linear	linear	JJ
cord-279343-ybncwweg	93	34	helical	helical	JJ
cord-279343-ybncwweg	93	35	concatenation	concatenation	NN
cord-279343-ybncwweg	93	36	model	model	NN
cord-279343-ybncwweg	93	37	predicts	predict	VBZ
cord-279343-ybncwweg	93	38	an	an	DT
cord-279343-ybncwweg	93	39	equal	equal	JJ
cord-279343-ybncwweg	93	40	proteasesensitivity	proteasesensitivity	NN
cord-279343-ybncwweg	93	41	for	for	IN
cord-279343-ybncwweg	93	42	each	each	DT
cord-279343-ybncwweg	93	43	repeat	repeat	NN
cord-279343-ybncwweg	93	44	.	.	.
cord-279343-ybncwweg	94	1	The	the	DT
cord-279343-ybncwweg	94	2	digestion	digestion	NN
cord-279343-ybncwweg	94	3	with	with	IN
cord-279343-ybncwweg	94	4	trypsin	trypsin	NN
cord-279343-ybncwweg	94	5	was	be	VBD
cord-279343-ybncwweg	94	6	carried	carry	VBN
cord-279343-ybncwweg	94	7	out	out	RP
cord-279343-ybncwweg	94	8	using	use	VBG
cord-279343-ybncwweg	94	9	a	a	DT
cord-279343-ybncwweg	94	10	recombinant	recombinant	NN
cord-279343-ybncwweg	94	11	expressed	express	VBN
cord-279343-ybncwweg	94	12	and	and	CC
cord-279343-ybncwweg	94	13	refolded	refolde	VBN
cord-279343-ybncwweg	94	14	full	full	JJ
cord-279343-ybncwweg	94	15	extracellular	extracellular	JJ
cord-279343-ybncwweg	94	16	DC	DC	NNP
cord-279343-ybncwweg	94	17	-	-	HYPH
cord-279343-ybncwweg	94	18	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	94	19	,	,	,
cord-279343-ybncwweg	94	20	termed	term	VBD
cord-279343-ybncwweg	94	21	DC	DC	NNP
cord-279343-ybncwweg	94	22	-	-	HYPH
cord-279343-ybncwweg	94	23	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	94	24	R1	R1	NNP
cord-279343-ybncwweg	94	25	,	,	,
cord-279343-ybncwweg	94	26	that	that	WDT
cord-279343-ybncwweg	94	27	has	have	VBZ
cord-279343-ybncwweg	94	28	been	be	VBN
cord-279343-ybncwweg	94	29	characterized	characterize	VBN
cord-279343-ybncwweg	94	30	to	to	TO
cord-279343-ybncwweg	94	31	be	be	VB
cord-279343-ybncwweg	94	32	a	a	DT
cord-279343-ybncwweg	94	33	tetramer	tetramer	NN
cord-279343-ybncwweg	94	34	.	.	.
cord-279343-ybncwweg	95	1	21	21	CD
cord-279343-ybncwweg	95	2	Digestion	digestion	NN
cord-279343-ybncwweg	95	3	of	of	IN
cord-279343-ybncwweg	95	4	DC	DC	NNP
cord-279343-ybncwweg	95	5	-	-	HYPH
cord-279343-ybncwweg	95	6	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	95	7	R1	r1	NN
cord-279343-ybncwweg	95	8	with	with	IN
cord-279343-ybncwweg	95	9	trypsin	trypsin	NN
cord-279343-ybncwweg	95	10	resulted	result	VBD
cord-279343-ybncwweg	95	11	in	in	IN
cord-279343-ybncwweg	95	12	four	four	CD
cord-279343-ybncwweg	95	13	major	major	JJ
cord-279343-ybncwweg	95	14	fragments	fragment	NNS
cord-279343-ybncwweg	95	15	F1w25	F1w25	NNP
cord-279343-ybncwweg	95	16	kDa	kDa	NNP
cord-279343-ybncwweg	95	17	,	,	,
cord-279343-ybncwweg	95	18	F2w9	F2w9	NNP
cord-279343-ybncwweg	95	19	kDa	kDa	NNP
cord-279343-ybncwweg	95	20	8	8	CD
cord-279343-ybncwweg	95	21	,	,	,
cord-279343-ybncwweg	95	22	F3w19	F3w19	NNP
cord-279343-ybncwweg	95	23	kDa	kDa	NNP
cord-279343-ybncwweg	95	24	,	,	,
cord-279343-ybncwweg	95	25	and	and	CC
cord-279343-ybncwweg	95	26	F4w7	F4w7	NNP
cord-279343-ybncwweg	95	27	kDa	kDa	NNP
cord-279343-ybncwweg	95	28	,	,	,
cord-279343-ybncwweg	95	29	with	with	IN
cord-279343-ybncwweg	95	30	the	the	DT
cord-279343-ybncwweg	95	31	F1	F1	NNP
cord-279343-ybncwweg	95	32	and	and	CC
cord-279343-ybncwweg	95	33	F2	f2	NN
cord-279343-ybncwweg	95	34	appearing	appear	VBG
cord-279343-ybncwweg	95	35	before	before	IN
cord-279343-ybncwweg	95	36	F3	F3	NNP
cord-279343-ybncwweg	95	37	and	and	CC
cord-279343-ybncwweg	95	38	F4	F4	NNP
cord-279343-ybncwweg	95	39	in	in	IN
cord-279343-ybncwweg	95	40	time	time	NN
cord-279343-ybncwweg	95	41	-	-	HYPH
cord-279343-ybncwweg	95	42	based	base	VBN
cord-279343-ybncwweg	95	43	digestions	digestion	NNS
cord-279343-ybncwweg	95	44	(	(	-LRB-
cord-279343-ybncwweg	95	45	Supplementary	Supplementary	NNP
cord-279343-ybncwweg	95	46	Data	Data	NNP
cord-279343-ybncwweg	95	47	Figure	Figure	NNP
cord-279343-ybncwweg	95	48	3	3	CD
cord-279343-ybncwweg	95	49	)	)	-RRB-
cord-279343-ybncwweg	95	50	.	.	.
cord-279343-ybncwweg	96	1	No	no	DT
cord-279343-ybncwweg	96	2	other	other	JJ
cord-279343-ybncwweg	96	3	intermediate	intermediate	JJ
cord-279343-ybncwweg	96	4	fragment	fragment	NN
cord-279343-ybncwweg	96	5	could	could	MD
cord-279343-ybncwweg	96	6	be	be	VB
cord-279343-ybncwweg	96	7	identified	identify	VBN
cord-279343-ybncwweg	96	8	.	.	.
cord-279343-ybncwweg	97	1	The	the	DT
cord-279343-ybncwweg	97	2	amino	amino	NN
cord-279343-ybncwweg	97	3	-	-	HYPH
cord-279343-ybncwweg	97	4	terminal	terminal	NN
cord-279343-ybncwweg	97	5	sequencing	sequencing	NN
cord-279343-ybncwweg	97	6	revealed	reveal	VBD
cord-279343-ybncwweg	97	7	fragments	fragment	NNS
cord-279343-ybncwweg	97	8	F1	F1	NNP
cord-279343-ybncwweg	97	9	(	(	-LRB-
cord-279343-ybncwweg	97	10	residues	residue	NNS
cord-279343-ybncwweg	97	11	14	14	CD
cord-279343-ybncwweg	97	12	-	-	SYM
cord-279343-ybncwweg	97	13	237	237	CD
cord-279343-ybncwweg	97	14	)	)	-RRB-
cord-279343-ybncwweg	97	15	and	and	CC
cord-279343-ybncwweg	97	16	F2	f2	NN
cord-279343-ybncwweg	97	17	(	(	-LRB-
cord-279343-ybncwweg	97	18	residues	residue	NNS
cord-279343-ybncwweg	97	19	238	238	CD
cord-279343-ybncwweg	97	20	-	-	HYPH
cord-279343-ybncwweg	97	21	313	313	CD
cord-279343-ybncwweg	97	22	)	)	-RRB-
cord-279343-ybncwweg	97	23	resulting	result	VBG
cord-279343-ybncwweg	97	24	from	from	IN
cord-279343-ybncwweg	97	25	cleavages	cleavage	NNS
cord-279343-ybncwweg	97	26	at	at	IN
cord-279343-ybncwweg	97	27	trypsin	trypsin	NN
cord-279343-ybncwweg	97	28	sites	site	NNS
cord-279343-ybncwweg	97	29	between	between	IN
cord-279343-ybncwweg	97	30	repeats	repeat	VBZ
cord-279343-ybncwweg	97	31	R1	R1	NNP
cord-279343-ybncwweg	97	32	and	and	CC
cord-279343-ybncwweg	97	33	R2	R2	NNP
cord-279343-ybncwweg	97	34	(	(	-LRB-
cord-279343-ybncwweg	97	35	site	site	NN
cord-279343-ybncwweg	97	36	1	1	CD
cord-279343-ybncwweg	97	37	)	)	-RRB-
cord-279343-ybncwweg	97	38	and	and	CC
cord-279343-ybncwweg	97	39	within	within	IN
cord-279343-ybncwweg	97	40	the	the	DT
cord-279343-ybncwweg	97	41	CRD	crd	NN
cord-279343-ybncwweg	97	42	(	(	-LRB-
cord-279343-ybncwweg	97	43	site	site	NN
cord-279343-ybncwweg	97	44	3	3	CD
cord-279343-ybncwweg	97	45	)	)	-RRB-
cord-279343-ybncwweg	97	46	.	.	.
cord-279343-ybncwweg	98	1	Fragments	fragment	NNS
cord-279343-ybncwweg	98	2	F3	F3	NNP
cord-279343-ybncwweg	98	3	(	(	-LRB-
cord-279343-ybncwweg	98	4	residues	residue	NNS
cord-279343-ybncwweg	98	5	14	14	CD
cord-279343-ybncwweg	98	6	-	-	SYM
cord-279343-ybncwweg	98	7	179	179	CD
cord-279343-ybncwweg	98	8	)	)	-RRB-
cord-279343-ybncwweg	98	9	and	and	CC
cord-279343-ybncwweg	98	10	F4	F4	NNP
cord-279343-ybncwweg	98	11	(	(	-LRB-
cord-279343-ybncwweg	98	12	residues	residue	VBZ
cord-279343-ybncwweg	98	13	270	270	CD
cord-279343-ybncwweg	98	14	-	-	SYM
cord-279343-ybncwweg	98	15	313	313	CD
cord-279343-ybncwweg	98	16	)	)	-RRB-
cord-279343-ybncwweg	98	17	appeared	appear	VBD
cord-279343-ybncwweg	98	18	to	to	TO
cord-279343-ybncwweg	98	19	be	be	VB
cord-279343-ybncwweg	98	20	derived	derive	VBN
cord-279343-ybncwweg	98	21	from	from	IN
cord-279343-ybncwweg	98	22	F1	f1	NN
cord-279343-ybncwweg	98	23	and	and	CC
cord-279343-ybncwweg	98	24	F2	f2	NN
cord-279343-ybncwweg	98	25	by	by	IN
cord-279343-ybncwweg	98	26	further	further	RB
cord-279343-ybncwweg	98	27	digesting	digest	VBG
cord-279343-ybncwweg	98	28	at	at	IN
cord-279343-ybncwweg	98	29	site	site	NN
cord-279343-ybncwweg	98	30	3	3	CD
cord-279343-ybncwweg	98	31	and	and	CC
cord-279343-ybncwweg	98	32	4	4	CD
cord-279343-ybncwweg	98	33	,	,	,
cord-279343-ybncwweg	98	34	respectively	respectively	RB
cord-279343-ybncwweg	98	35	(	(	-LRB-
cord-279343-ybncwweg	98	36	Figure	figure	NN
cord-279343-ybncwweg	98	37	1	1	CD
cord-279343-ybncwweg	98	38	)	)	-RRB-
cord-279343-ybncwweg	98	39	.	.	.
cord-279343-ybncwweg	99	1	These	these	DT
cord-279343-ybncwweg	99	2	results	result	NNS
cord-279343-ybncwweg	99	3	indicate	indicate	VBP
cord-279343-ybncwweg	99	4	that	that	IN
cord-279343-ybncwweg	99	5	most	most	JJS
cord-279343-ybncwweg	99	6	of	of	IN
cord-279343-ybncwweg	99	7	the	the	DT
cord-279343-ybncwweg	99	8	tetramerization	tetramerization	NN
cord-279343-ybncwweg	99	9	repeats	repeat	VBZ
cord-279343-ybncwweg	99	10	(	(	-LRB-
cord-279343-ybncwweg	99	11	R2-R8	R2-R8	NNP
cord-279343-ybncwweg	99	12	)	)	-RRB-
cord-279343-ybncwweg	99	13	remain	remain	VBP
cord-279343-ybncwweg	99	14	resistant	resistant	JJ
cord-279343-ybncwweg	99	15	to	to	IN
cord-279343-ybncwweg	99	16	digestion	digestion	NN
cord-279343-ybncwweg	99	17	by	by	IN
cord-279343-ybncwweg	99	18	trypsin	trypsin	NN
cord-279343-ybncwweg	99	19	,	,	,
cord-279343-ybncwweg	99	20	consistent	consistent	JJ
cord-279343-ybncwweg	99	21	with	with	IN
cord-279343-ybncwweg	99	22	it	-PRON-	PRP
cord-279343-ybncwweg	99	23	being	be	VBG
cord-279343-ybncwweg	99	24	a	a	DT
cord-279343-ybncwweg	99	25	compact	compact	JJ
cord-279343-ybncwweg	99	26	tetramer	tetramer	NN
cord-279343-ybncwweg	99	27	unit	unit	NN
cord-279343-ybncwweg	99	28	rather	rather	RB
cord-279343-ybncwweg	99	29	than	than	IN
cord-279343-ybncwweg	99	30	an	an	DT
cord-279343-ybncwweg	99	31	elongated	elongated	JJ
cord-279343-ybncwweg	99	32	linear	linear	JJ
cord-279343-ybncwweg	99	33	helical	helical	JJ
cord-279343-ybncwweg	99	34	tetramer	tetramer	NN
cord-279343-ybncwweg	99	35	in	in	IN
cord-279343-ybncwweg	99	36	which	which	WDT
cord-279343-ybncwweg	99	37	all	all	DT
cord-279343-ybncwweg	99	38	repeats	repeat	NNS
cord-279343-ybncwweg	99	39	appear	appear	VBP
cord-279343-ybncwweg	99	40	equally	equally	RB
cord-279343-ybncwweg	99	41	susceptible	susceptible	JJ
cord-279343-ybncwweg	99	42	to	to	IN
cord-279343-ybncwweg	99	43	protease	protease	NN
cord-279343-ybncwweg	99	44	.	.	.
cord-279343-ybncwweg	100	1	Digestion	digestion	NN
cord-279343-ybncwweg	100	2	experiments	experiment	NNS
cord-279343-ybncwweg	100	3	with	with	IN
cord-279343-ybncwweg	100	4	subtilisin	subtilisin	NNS
cord-279343-ybncwweg	100	5	are	be	VBP
cord-279343-ybncwweg	100	6	consistent	consistent	JJ
cord-279343-ybncwweg	100	7	with	with	IN
cord-279343-ybncwweg	100	8	these	these	DT
cord-279343-ybncwweg	100	9	results	result	NNS
cord-279343-ybncwweg	100	10	,	,	,
cord-279343-ybncwweg	100	11	indicating	indicate	VBG
cord-279343-ybncwweg	100	12	protease	protease	NN
cord-279343-ybncwweg	100	13	-	-	HYPH
cord-279343-ybncwweg	100	14	sensitive	sensitive	JJ
cord-279343-ybncwweg	100	15	sites	site	NNS
cord-279343-ybncwweg	100	16	being	be	VBG
cord-279343-ybncwweg	100	17	primarily	primarily	RB
cord-279343-ybncwweg	100	18	between	between	IN
cord-279343-ybncwweg	100	19	repeats	repeat	VBZ
cord-279343-ybncwweg	100	20	R1	R1	NNP
cord-279343-ybncwweg	100	21	and	and	CC
cord-279343-ybncwweg	100	22	R2	R2	NNP
cord-279343-ybncwweg	100	23	,	,	,
cord-279343-ybncwweg	100	24	and	and	CC
cord-279343-ybncwweg	100	25	after	after	IN
cord-279343-ybncwweg	100	26	the	the	DT
cord-279343-ybncwweg	100	27	helical	helical	JJ
cord-279343-ybncwweg	100	28	repeat	repeat	NN
cord-279343-ybncwweg	100	29	domain	domain	NN
cord-279343-ybncwweg	100	30	at	at	IN
cord-279343-ybncwweg	100	31	the	the	DT
cord-279343-ybncwweg	100	32	beginning	beginning	NN
cord-279343-ybncwweg	100	33	of	of	IN
cord-279343-ybncwweg	100	34	the	the	DT
cord-279343-ybncwweg	100	35	CRD	CRD	NNP
cord-279343-ybncwweg	100	36	region	region	NN
cord-279343-ybncwweg	100	37	.	.	.
cord-279343-ybncwweg	101	1	22	22	CD
cord-279343-ybncwweg	101	2	Evaluating	evaluate	VBG
cord-279343-ybncwweg	101	3	potential	potential	JJ
cord-279343-ybncwweg	101	4	DC	DC	NNP
cord-279343-ybncwweg	101	5	-	-	HYPH
cord-279343-ybncwweg	101	6	SIGN	sign	NN
cord-279343-ybncwweg	101	7	/	/	SYM
cord-279343-ybncwweg	101	8	R	r	NN
cord-279343-ybncwweg	101	9	ligands	ligand	NNS
cord-279343-ybncwweg	102	1	Earlier	early	JJR
cord-279343-ybncwweg	102	2	studies	study	NNS
cord-279343-ybncwweg	102	3	of	of	IN
cord-279343-ybncwweg	102	4	the	the	DT
cord-279343-ybncwweg	102	5	DC	DC	NNP
cord-279343-ybncwweg	102	6	-	-	HYPH
cord-279343-ybncwweg	102	7	SIGN	SIGN	NNP
cord-279343-ybncwweg	102	8	/	/	SYM
cord-279343-ybncwweg	102	9	R	r	NN
cord-279343-ybncwweg	102	10	CRD	crd	NN
cord-279343-ybncwweg	102	11	binding	bind	VBG
cord-279343-ybncwweg	102	12	to	to	IN
cord-279343-ybncwweg	102	13	model	model	NN
cord-279343-ybncwweg	102	14	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	102	15	compounds	compound	NNS
cord-279343-ybncwweg	102	16	suggest	suggest	VBP
cord-279343-ybncwweg	102	17	that	that	IN
cord-279343-ybncwweg	102	18	the	the	DT
cord-279343-ybncwweg	102	19	receptors	receptor	NNS
cord-279343-ybncwweg	102	20	prefer	prefer	VBP
cord-279343-ybncwweg	102	21	a	a	DT
cord-279343-ybncwweg	102	22	high	high	JJ
cord-279343-ybncwweg	102	23	-	-	HYPH
cord-279343-ybncwweg	102	24	mannose	mannose	NN
cord-279343-ybncwweg	102	25	type	type	NN
cord-279343-ybncwweg	102	26	of	of	IN
cord-279343-ybncwweg	102	27	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	102	28	.	.	.
cord-279343-ybncwweg	103	1	17	17	CD
cord-279343-ybncwweg	103	2	,	,	,
cord-279343-ybncwweg	103	3	18	18	CD
cord-279343-ybncwweg	103	4	,	,	,
cord-279343-ybncwweg	104	1	26	26	CD
cord-279343-ybncwweg	104	2	More	more	RBR
cord-279343-ybncwweg	104	3	recently	recently	RB
cord-279343-ybncwweg	104	4	,	,	,
cord-279343-ybncwweg	104	5	the	the	DT
cord-279343-ybncwweg	104	6	receptors	receptor	NNS
cord-279343-ybncwweg	104	7	were	be	VBD
cord-279343-ybncwweg	104	8	shown	show	VBN
cord-279343-ybncwweg	104	9	to	to	TO
cord-279343-ybncwweg	104	10	recognize	recognize	VB
cord-279343-ybncwweg	104	11	also	also	RB
cord-279343-ybncwweg	104	12	sialyl	sialyl	NNP
cord-279343-ybncwweg	104	13	-	-	HYPH
cord-279343-ybncwweg	104	14	Lewis	Lewis	NNP
cord-279343-ybncwweg	104	15	-	-	HYPH
cord-279343-ybncwweg	104	16	like	like	JJ
cord-279343-ybncwweg	104	17	carbohydrates	carbohydrate	NNS
cord-279343-ybncwweg	104	18	.	.	.
cord-279343-ybncwweg	105	1	19	19	CD
cord-279343-ybncwweg	106	1	The	the	DT
cord-279343-ybncwweg	106	2	dissociation	dissociation	NN
cord-279343-ybncwweg	106	3	constant	constant	NN
cord-279343-ybncwweg	106	4	(	(	-LRB-
cord-279343-ybncwweg	106	5	K	K	NNP
cord-279343-ybncwweg	106	6	d	d	NNP
cord-279343-ybncwweg	106	7	)	)	-RRB-
cord-279343-ybncwweg	106	8	between	between	IN
cord-279343-ybncwweg	106	9	DC	DC	NNP
cord-279343-ybncwweg	106	10	-	-	HYPH
cord-279343-ybncwweg	106	11	SIGN	SIGN	NNP
cord-279343-ybncwweg	106	12	/	/	SYM
cord-279343-ybncwweg	106	13	R	R	NNP
cord-279343-ybncwweg	106	14	CRD	crd	NN
cord-279343-ybncwweg	106	15	and	and	CC
cord-279343-ybncwweg	106	16	the	the	DT
cord-279343-ybncwweg	106	17	model	model	NN
cord-279343-ybncwweg	106	18	compounds	compound	NNS
cord-279343-ybncwweg	106	19	,	,	,
cord-279343-ybncwweg	106	20	however	however	RB
cord-279343-ybncwweg	106	21	,	,	,
cord-279343-ybncwweg	106	22	are	be	VBP
cord-279343-ybncwweg	106	23	millimolar	millimolar	JJ
cord-279343-ybncwweg	106	24	at	at	IN
cord-279343-ybncwweg	106	25	best	well	RBS
cord-279343-ybncwweg	106	26	,	,	,
cord-279343-ybncwweg	106	27	while	while	IN
cord-279343-ybncwweg	106	28	the	the	DT
cord-279343-ybncwweg	106	29	functional	functional	JJ
cord-279343-ybncwweg	106	30	ligand	ligand	NN
cord-279343-ybncwweg	106	31	recognition	recognition	NN
cord-279343-ybncwweg	106	32	by	by	IN
cord-279343-ybncwweg	106	33	the	the	DT
cord-279343-ybncwweg	106	34	receptor	receptor	NN
cord-279343-ybncwweg	106	35	has	have	VBZ
cord-279343-ybncwweg	106	36	better	well	JJR
cord-279343-ybncwweg	106	37	than	than	IN
cord-279343-ybncwweg	106	38	micromolar	micromolar	JJ
cord-279343-ybncwweg	106	39	affinity	affinity	NN
cord-279343-ybncwweg	106	40	.	.	.
cord-279343-ybncwweg	107	1	Thus	thus	RB
cord-279343-ybncwweg	107	2	,	,	,
cord-279343-ybncwweg	107	3	much	much	JJ
cord-279343-ybncwweg	107	4	of	of	IN
cord-279343-ybncwweg	107	5	the	the	DT
cord-279343-ybncwweg	107	6	receptorligand	receptorligand	NN
cord-279343-ybncwweg	107	7	binding	bind	VBG
cord-279343-ybncwweg	107	8	affinity	affinity	NN
cord-279343-ybncwweg	107	9	appears	appear	VBZ
cord-279343-ybncwweg	107	10	to	to	TO
cord-279343-ybncwweg	107	11	be	be	VB
cord-279343-ybncwweg	107	12	derived	derive	VBN
cord-279343-ybncwweg	107	13	from	from	IN
cord-279343-ybncwweg	107	14	an	an	DT
cord-279343-ybncwweg	107	15	avidity	avidity	NN
cord-279343-ybncwweg	107	16	effect	effect	NN
cord-279343-ybncwweg	107	17	of	of	IN
cord-279343-ybncwweg	107	18	the	the	DT
cord-279343-ybncwweg	107	19	DC	DC	NNP
cord-279343-ybncwweg	107	20	-	-	HYPH
cord-279343-ybncwweg	107	21	SIGN	SIGN	NNP
cord-279343-ybncwweg	107	22	/	/	SYM
cord-279343-ybncwweg	107	23	R	r	NN
cord-279343-ybncwweg	107	24	tetramer	tetramer	NN
cord-279343-ybncwweg	107	25	.	.	.
cord-279343-ybncwweg	108	1	The	the	DT
cord-279343-ybncwweg	108	2	requirement	requirement	NN
cord-279343-ybncwweg	108	3	of	of	IN
cord-279343-ybncwweg	108	4	tetramer	tetramer	NN
cord-279343-ybncwweg	108	5	binding	bind	VBG
cord-279343-ybncwweg	108	6	for	for	IN
cord-279343-ybncwweg	108	7	ligand	ligand	NN
cord-279343-ybncwweg	108	8	recognition	recognition	NN
cord-279343-ybncwweg	108	9	would	would	MD
cord-279343-ybncwweg	108	10	,	,	,
cord-279343-ybncwweg	108	11	in	in	IN
cord-279343-ybncwweg	108	12	turn	turn	NN
cord-279343-ybncwweg	108	13	,	,	,
cord-279343-ybncwweg	108	14	impose	impose	VB
cord-279343-ybncwweg	108	15	limitations	limitation	NNS
cord-279343-ybncwweg	108	16	to	to	IN
cord-279343-ybncwweg	108	17	its	-PRON-	PRP$
cord-279343-ybncwweg	108	18	ligand	ligand	NN
cord-279343-ybncwweg	108	19	selection	selection	NN
cord-279343-ybncwweg	108	20	.	.	.
cord-279343-ybncwweg	109	1	Namely	namely	RB
cord-279343-ybncwweg	109	2	,	,	,
cord-279343-ybncwweg	109	3	ligands	ligand	NNS
cord-279343-ybncwweg	109	4	carrying	carry	VBG
cord-279343-ybncwweg	109	5	multiple	multiple	JJ
cord-279343-ybncwweg	109	6	glycosylations	glycosylation	NNS
cord-279343-ybncwweg	109	7	capable	capable	JJ
cord-279343-ybncwweg	109	8	of	of	IN
cord-279343-ybncwweg	109	9	engaging	engage	VBG
cord-279343-ybncwweg	109	10	the	the	DT
cord-279343-ybncwweg	109	11	multimeric	multimeric	JJ
cord-279343-ybncwweg	109	12	DC	DC	NNP
cord-279343-ybncwweg	109	13	-	-	HYPH
cord-279343-ybncwweg	109	14	SIGN	SIGN	NNP
cord-279343-ybncwweg	109	15	/	/	SYM
cord-279343-ybncwweg	109	16	R	r	NN
cord-279343-ybncwweg	109	17	CRD	crd	NN
cord-279343-ybncwweg	109	18	simultaneously	simultaneously	RB
cord-279343-ybncwweg	109	19	would	would	MD
cord-279343-ybncwweg	109	20	be	be	VB
cord-279343-ybncwweg	109	21	preferred	prefer	VBN
cord-279343-ybncwweg	109	22	by	by	IN
cord-279343-ybncwweg	109	23	the	the	DT
cord-279343-ybncwweg	109	24	receptor	receptor	NN
cord-279343-ybncwweg	109	25	.	.	.
cord-279343-ybncwweg	110	1	The	the	DT
cord-279343-ybncwweg	110	2	surface	surface	NN
cord-279343-ybncwweg	110	3	area	area	NN
cord-279343-ybncwweg	110	4	encompassed	encompass	VBN
cord-279343-ybncwweg	110	5	by	by	IN
cord-279343-ybncwweg	110	6	the	the	DT
cord-279343-ybncwweg	110	7	tetrameric	tetrameric	JJ
cord-279343-ybncwweg	110	8	CRD	crd	NN
cord-279343-ybncwweg	110	9	in	in	IN
cord-279343-ybncwweg	110	10	our	-PRON-	PRP$
cord-279343-ybncwweg	110	11	current	current	JJ
cord-279343-ybncwweg	110	12	DC	DC	NNP
cord-279343-ybncwweg	110	13	-	-	HYPH
cord-279343-ybncwweg	110	14	SIGN	sign	NN
cord-279343-ybncwweg	110	15	/	/	SYM
cord-279343-ybncwweg	110	16	R	r	NN
cord-279343-ybncwweg	110	17	model	model	NN
cord-279343-ybncwweg	110	18	is	be	VBZ
cord-279343-ybncwweg	110	19	approximately	approximately	RB
cord-279343-ybncwweg	110	20	6400	6400	CD
cord-279343-ybncwweg	110	21	Å	å	NN
cord-279343-ybncwweg	110	22	2	2	CD
cord-279343-ybncwweg	110	23	,	,	,
cord-279343-ybncwweg	110	24	or	or	CC
cord-279343-ybncwweg	110	25	1600	1600	CD
cord-279343-ybncwweg	110	26	Å	å	NN
cord-279343-ybncwweg	110	27	2	2	CD
cord-279343-ybncwweg	110	28	per	per	IN
cord-279343-ybncwweg	110	29	CRD	crd	NN
cord-279343-ybncwweg	110	30	molecule	molecule	NN
cord-279343-ybncwweg	110	31	.	.	.
cord-279343-ybncwweg	111	1	This	this	DT
cord-279343-ybncwweg	111	2	requires	require	VBZ
cord-279343-ybncwweg	111	3	the	the	DT
cord-279343-ybncwweg	111	4	potential	potential	JJ
cord-279343-ybncwweg	111	5	ligands	ligand	NNS
cord-279343-ybncwweg	111	6	of	of	IN
cord-279343-ybncwweg	111	7	DC	DC	NNP
cord-279343-ybncwweg	111	8	-	-	HYPH
cord-279343-ybncwweg	111	9	SIGN	SIGN	NNP
cord-279343-ybncwweg	111	10	/	/	SYM
cord-279343-ybncwweg	111	11	R	r	NN
cord-279343-ybncwweg	111	12	to	to	TO
cord-279343-ybncwweg	111	13	possess	possess	VB
cord-279343-ybncwweg	111	14	a	a	DT
cord-279343-ybncwweg	111	15	surface	surface	NN
cord-279343-ybncwweg	111	16	glycosylation	glycosylation	NN
cord-279343-ybncwweg	111	17	level	level	NN
cord-279343-ybncwweg	111	18	exceeding	exceed	VBG
cord-279343-ybncwweg	111	19	one	one	CD
cord-279343-ybncwweg	111	20	glycan	glycan	NN
cord-279343-ybncwweg	111	21	molecule	molecule	NN
cord-279343-ybncwweg	111	22	per	per	IN
cord-279343-ybncwweg	111	23	1600	1600	CD
cord-279343-ybncwweg	111	24	Å	å	NN
cord-279343-ybncwweg	111	25	2	2	CD
cord-279343-ybncwweg	111	26	of	of	IN
cord-279343-ybncwweg	111	27	its	-PRON-	PRP$
cord-279343-ybncwweg	111	28	surface	surface	NN
cord-279343-ybncwweg	111	29	area	area	NN
cord-279343-ybncwweg	111	30	.	.	.
cord-279343-ybncwweg	112	1	This	this	DT
cord-279343-ybncwweg	112	2	enables	enable	VBZ
cord-279343-ybncwweg	112	3	us	-PRON-	PRP
cord-279343-ybncwweg	112	4	to	to	TO
cord-279343-ybncwweg	112	5	formulate	formulate	VB
cord-279343-ybncwweg	112	6	a	a	DT
cord-279343-ybncwweg	112	7	potential	potential	JJ
cord-279343-ybncwweg	112	8	ligand	ligand	NN
cord-279343-ybncwweg	112	9	index	index	NN
cord-279343-ybncwweg	112	10	i	i	PRP
cord-279343-ybncwweg	112	11	to	to	TO
cord-279343-ybncwweg	112	12	evaluate	evaluate	VB
cord-279343-ybncwweg	112	13	potential	potential	JJ
cord-279343-ybncwweg	112	14	ligands	ligand	NNS
cord-279343-ybncwweg	112	15	of	of	IN
cord-279343-ybncwweg	112	16	DC	DC	NNP
cord-279343-ybncwweg	112	17	-	-	HYPH
cord-279343-ybncwweg	112	18	SIGN	SIGN	NNP
cord-279343-ybncwweg	112	19	/	/	SYM
cord-279343-ybncwweg	112	20	R	r	NN
cord-279343-ybncwweg	112	21	on	on	IN
cord-279343-ybncwweg	112	22	the	the	DT
cord-279343-ybncwweg	112	23	basis	basis	NN
cord-279343-ybncwweg	112	24	of	of	IN
cord-279343-ybncwweg	112	25	their	-PRON-	PRP$
cord-279343-ybncwweg	112	26	surface	surface	NN
cord-279343-ybncwweg	112	27	glycosylation	glycosylation	NN
cord-279343-ybncwweg	112	28	density	density	NN
cord-279343-ybncwweg	112	29	:	:	:
cord-279343-ybncwweg	112	30	(	(	-LRB-
cord-279343-ybncwweg	112	31	1	1	LS
cord-279343-ybncwweg	112	32	)	)	-RRB-
cord-279343-ybncwweg	112	33	where	where	WRB
cord-279343-ybncwweg	112	34	N	N	NNP
cord-279343-ybncwweg	112	35	is	be	VBZ
cord-279343-ybncwweg	112	36	the	the	DT
cord-279343-ybncwweg	112	37	number	number	NN
cord-279343-ybncwweg	112	38	of	of	IN
cord-279343-ybncwweg	112	39	predicted	predict	VBN
cord-279343-ybncwweg	112	40	potential	potential	JJ
cord-279343-ybncwweg	112	41	glycosylation	glycosylation	NN
cord-279343-ybncwweg	112	42	sites	site	NNS
cord-279343-ybncwweg	112	43	and	and	CC
cord-279343-ybncwweg	112	44	M	M	NNP
cord-279343-ybncwweg	112	45	is	be	VBZ
cord-279343-ybncwweg	112	46	the	the	DT
cord-279343-ybncwweg	112	47	molecular	molecular	JJ
cord-279343-ybncwweg	112	48	mass	mass	NN
cord-279343-ybncwweg	112	49	of	of	IN
cord-279343-ybncwweg	112	50	the	the	DT
cord-279343-ybncwweg	112	51	candidate	candidate	NN
cord-279343-ybncwweg	112	52	protein	protein	NN
cord-279343-ybncwweg	112	53	.	.	.
cord-279343-ybncwweg	113	1	A	a	DT
cord-279343-ybncwweg	113	2	potential	potential	JJ
cord-279343-ybncwweg	113	3	DC	DC	NNP
cord-279343-ybncwweg	113	4	-	-	HYPH
cord-279343-ybncwweg	113	5	SIGN	sign	NN
cord-279343-ybncwweg	113	6	/	/	SYM
cord-279343-ybncwweg	113	7	R	r	NN
cord-279343-ybncwweg	113	8	ligand	ligand	NN
cord-279343-ybncwweg	113	9	would	would	MD
cord-279343-ybncwweg	113	10	possess	possess	VB
cord-279343-ybncwweg	113	11	an	an	DT
cord-279343-ybncwweg	113	12	index	index	NN
cord-279343-ybncwweg	113	13	greater	great	JJR
cord-279343-ybncwweg	113	14	than	than	IN
cord-279343-ybncwweg	113	15	1.0	1.0	CD
cord-279343-ybncwweg	113	16	and	and	CC
cord-279343-ybncwweg	113	17	proteins	protein	NNS
cord-279343-ybncwweg	113	18	with	with	IN
cord-279343-ybncwweg	113	19	the	the	DT
cord-279343-ybncwweg	113	20	indices	index	NNS
cord-279343-ybncwweg	114	1	less	less	JJR
cord-279343-ybncwweg	114	2	than	than	IN
cord-279343-ybncwweg	114	3	1.0	1.0	CD
cord-279343-ybncwweg	114	4	are	be	VBP
cord-279343-ybncwweg	114	5	less	less	RBR
cord-279343-ybncwweg	114	6	likely	likely	JJ
cord-279343-ybncwweg	114	7	to	to	TO
cord-279343-ybncwweg	114	8	be	be	VB
cord-279343-ybncwweg	114	9	ligands	ligand	NNS
cord-279343-ybncwweg	114	10	of	of	IN
cord-279343-ybncwweg	114	11	the	the	DT
cord-279343-ybncwweg	114	12	receptor	receptor	NN
cord-279343-ybncwweg	114	13	.	.	.
cord-279343-ybncwweg	115	1	The	the	DT
cord-279343-ybncwweg	115	2	calculation	calculation	NN
cord-279343-ybncwweg	115	3	of	of	IN
cord-279343-ybncwweg	115	4	this	this	DT
cord-279343-ybncwweg	115	5	potential	potential	JJ
cord-279343-ybncwweg	115	6	ligand	ligand	NN
cord-279343-ybncwweg	115	7	index	index	NN
cord-279343-ybncwweg	115	8	for	for	IN
cord-279343-ybncwweg	115	9	a	a	DT
cord-279343-ybncwweg	115	10	number	number	NN
cord-279343-ybncwweg	115	11	of	of	IN
cord-279343-ybncwweg	115	12	viral	viral	JJ
cord-279343-ybncwweg	115	13	envelope	envelope	NN
cord-279343-ybncwweg	115	14	glycoproteins	glycoprotein	NNS
cord-279343-ybncwweg	115	15	as	as	RB
cord-279343-ybncwweg	115	16	well	well	RB
cord-279343-ybncwweg	115	17	as	as	IN
cord-279343-ybncwweg	115	18	for	for	IN
cord-279343-ybncwweg	115	19	some	some	DT
cord-279343-ybncwweg	115	20	cell	cell	NN
cord-279343-ybncwweg	115	21	-	-	HYPH
cord-279343-ybncwweg	115	22	surface	surface	NN
cord-279343-ybncwweg	115	23	glycoproteins	glycoprotein	NNS
cord-279343-ybncwweg	115	24	is	be	VBZ
cord-279343-ybncwweg	115	25	summarized	summarize	VBN
cord-279343-ybncwweg	115	26	in	in	IN
cord-279343-ybncwweg	115	27	Table	Table	NNP
cord-279343-ybncwweg	115	28	3	3	CD
cord-279343-ybncwweg	115	29	.	.	.
cord-279343-ybncwweg	116	1	Of	of	IN
cord-279343-ybncwweg	116	2	the	the	DT
cord-279343-ybncwweg	116	3	potential	potential	JJ
cord-279343-ybncwweg	116	4	viral	viral	JJ
cord-279343-ybncwweg	116	5	targets	target	NNS
cord-279343-ybncwweg	116	6	of	of	IN
cord-279343-ybncwweg	116	7	DC	DC	NNP
cord-279343-ybncwweg	116	8	-	-	HYPH
cord-279343-ybncwweg	116	9	SIGN	SIGN	NNP
cord-279343-ybncwweg	116	10	/	/	SYM
cord-279343-ybncwweg	116	11	R	R	NNP
cord-279343-ybncwweg	116	12	,	,	,
cord-279343-ybncwweg	116	13	HIV-1	HIV-1	NNP
cord-279343-ybncwweg	116	14	,	,	,
cord-279343-ybncwweg	116	15	coronavirus	coronavirus	NN
cord-279343-ybncwweg	116	16	and	and	CC
cord-279343-ybncwweg	116	17	Marburg	Marburg	NNP
cord-279343-ybncwweg	116	18	virus	virus	NN
cord-279343-ybncwweg	116	19	are	be	VBP
cord-279343-ybncwweg	116	20	known	know	VBN
cord-279343-ybncwweg	116	21	to	to	TO
cord-279343-ybncwweg	116	22	bind	bind	VB
cord-279343-ybncwweg	116	23	DC	DC	NNP
cord-279343-ybncwweg	116	24	-	-	HYPH
cord-279343-ybncwweg	116	25	SIGN	SIGN	NNP
cord-279343-ybncwweg	116	26	.	.	.
cord-279343-ybncwweg	117	1	In	in	IN
cord-279343-ybncwweg	117	2	addition	addition	NN
cord-279343-ybncwweg	117	3	,	,	,
cord-279343-ybncwweg	117	4	HRSV	HRSV	NNP
cord-279343-ybncwweg	117	5	,	,	,
cord-279343-ybncwweg	117	6	influenza	influenza	NN
cord-279343-ybncwweg	117	7	and	and	CC
cord-279343-ybncwweg	117	8	human	human	JJ
cord-279343-ybncwweg	117	9	foamy	foamy	NN
cord-279343-ybncwweg	117	10	viruses	virus	NNS
cord-279343-ybncwweg	117	11	appear	appear	VBP
cord-279343-ybncwweg	117	12	to	to	TO
cord-279343-ybncwweg	117	13	be	be	VB
cord-279343-ybncwweg	117	14	good	good	JJ
cord-279343-ybncwweg	117	15	candidates	candidate	NNS
cord-279343-ybncwweg	117	16	for	for	IN
cord-279343-ybncwweg	117	17	DC	DC	NNP
cord-279343-ybncwweg	117	18	-	-	HYPH
cord-279343-ybncwweg	117	19	SIGN	SIGN	NNP
cord-279343-ybncwweg	117	20	/	/	SYM
cord-279343-ybncwweg	117	21	R.	R.	NNP
cord-279343-ybncwweg	118	1	Among	among	IN
cord-279343-ybncwweg	118	2	the	the	DT
cord-279343-ybncwweg	118	3	cellular	cellular	JJ
cord-279343-ybncwweg	118	4	targets	target	NNS
cord-279343-ybncwweg	118	5	,	,	,
cord-279343-ybncwweg	118	6	in	in	IN
cord-279343-ybncwweg	118	7	addition	addition	NN
cord-279343-ybncwweg	118	8	to	to	IN
cord-279343-ybncwweg	118	9	the	the	DT
cord-279343-ybncwweg	118	10	known	know	VBN
cord-279343-ybncwweg	118	11	ICAM-3	icam-3	JJ
cord-279343-ybncwweg	118	12	ligand	ligand	NN
cord-279343-ybncwweg	118	13	,	,	,
cord-279343-ybncwweg	118	14	several	several	JJ
cord-279343-ybncwweg	118	15	surface	surface	NN
cord-279343-ybncwweg	118	16	glycoproteins	glycoprotein	NNS
cord-279343-ybncwweg	118	17	also	also	RB
cord-279343-ybncwweg	118	18	score	score	VBP
cord-279343-ybncwweg	118	19	favorably	favorably	RB
cord-279343-ybncwweg	118	20	for	for	IN
cord-279343-ybncwweg	118	21	DC	DC	NNP
cord-279343-ybncwweg	118	22	-	-	HYPH
cord-279343-ybncwweg	118	23	SIGN	sign	NN
cord-279343-ybncwweg	118	24	binding	binding	NN
cord-279343-ybncwweg	118	25	.	.	.
cord-279343-ybncwweg	119	1	DC	DC	NNP
cord-279343-ybncwweg	119	2	-	-	HYPH
cord-279343-ybncwweg	119	3	SIGN	SIGN	NNP
cord-279343-ybncwweg	119	4	and	and	CC
cord-279343-ybncwweg	119	5	DC	DC	NNP
cord-279343-ybncwweg	119	6	-	-	HYPH
cord-279343-ybncwweg	119	7	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	119	8	are	be	VBP
cord-279343-ybncwweg	119	9	part	part	NN
cord-279343-ybncwweg	119	10	of	of	IN
cord-279343-ybncwweg	119	11	an	an	DT
cord-279343-ybncwweg	119	12	antigencapturing	antigencapture	VBG
cord-279343-ybncwweg	119	13	network	network	NN
cord-279343-ybncwweg	119	14	of	of	IN
cord-279343-ybncwweg	119	15	receptors	receptor	NNS
cord-279343-ybncwweg	119	16	expressed	express	VBN
cord-279343-ybncwweg	119	17	on	on	IN
cord-279343-ybncwweg	119	18	dendritic	dendritic	JJ
cord-279343-ybncwweg	119	19	cells	cell	NNS
cord-279343-ybncwweg	119	20	.	.	.
cord-279343-ybncwweg	120	1	Previously	previously	RB
cord-279343-ybncwweg	120	2	,	,	,
cord-279343-ybncwweg	120	3	the	the	DT
cord-279343-ybncwweg	120	4	structures	structure	NNS
cord-279343-ybncwweg	120	5	of	of	IN
cord-279343-ybncwweg	120	6	a	a	DT
cord-279343-ybncwweg	120	7	mannose	mannose	NN
cord-279343-ybncwweg	120	8	-	-	HYPH
cord-279343-ybncwweg	120	9	bound	bind	VBN
cord-279343-ybncwweg	120	10	and	and	CC
cord-279343-ybncwweg	120	11	a	a	DT
cord-279343-ybncwweg	120	12	Lewis	Lewis	NNP
cord-279343-ybncwweg	120	13	x	x	:
cord-279343-ybncwweg	120	14	-bound	-bound	VBN
cord-279343-ybncwweg	120	15	form	form	NN
cord-279343-ybncwweg	120	16	of	of	IN
cord-279343-ybncwweg	120	17	the	the	DT
cord-279343-ybncwweg	120	18	receptor	receptor	NN
cord-279343-ybncwweg	120	19	showed	show	VBD
cord-279343-ybncwweg	120	20	critical	critical	JJ
cord-279343-ybncwweg	120	21	residues	residue	NNS
cord-279343-ybncwweg	120	22	involved	involve	VBN
cord-279343-ybncwweg	120	23	in	in	IN
cord-279343-ybncwweg	120	24	both	both	DT
cord-279343-ybncwweg	120	25	calcium	calcium	NN
cord-279343-ybncwweg	120	26	and	and	CC
cord-279343-ybncwweg	120	27	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	120	28	interactions	interaction	NNS
cord-279343-ybncwweg	120	29	.	.	.
cord-279343-ybncwweg	121	1	18	18	CD
cord-279343-ybncwweg	121	2	,	,	,
cord-279343-ybncwweg	121	3	19	19	CD
cord-279343-ybncwweg	121	4	Our	-PRON-	PRP$
cord-279343-ybncwweg	121	5	current	current	JJ
cord-279343-ybncwweg	121	6	structure	structure	NN
cord-279343-ybncwweg	121	7	of	of	IN
cord-279343-ybncwweg	121	8	DC	DC	NNP
cord-279343-ybncwweg	121	9	-	-	HYPH
cord-279343-ybncwweg	121	10	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	121	11	R8	R8	NNP
cord-279343-ybncwweg	121	12	represents	represent	VBZ
cord-279343-ybncwweg	121	13	an	an	DT
cord-279343-ybncwweg	121	14	apo	apo	NNP
cord-279343-ybncwweg	121	15	form	form	NN
cord-279343-ybncwweg	121	16	of	of	IN
cord-279343-ybncwweg	121	17	the	the	DT
cord-279343-ybncwweg	121	18	receptor	receptor	NN
cord-279343-ybncwweg	121	19	.	.	.
cord-279343-ybncwweg	122	1	The	the	DT
cord-279343-ybncwweg	122	2	structure	structure	NN
cord-279343-ybncwweg	122	3	revealed	reveal	VBD
cord-279343-ybncwweg	122	4	that	that	IN
cord-279343-ybncwweg	122	5	much	much	JJ
cord-279343-ybncwweg	122	6	of	of	IN
cord-279343-ybncwweg	122	7	the	the	DT
cord-279343-ybncwweg	122	8	CRD	CRD	NNP
cord-279343-ybncwweg	122	9	adopts	adopt	VBZ
cord-279343-ybncwweg	122	10	a	a	DT
cord-279343-ybncwweg	122	11	conformation	conformation	NN
cord-279343-ybncwweg	122	12	very	very	RB
cord-279343-ybncwweg	122	13	similar	similar	JJ
cord-279343-ybncwweg	122	14	to	to	IN
cord-279343-ybncwweg	122	15	that	that	DT
cord-279343-ybncwweg	122	16	observed	observe	VBN
cord-279343-ybncwweg	122	17	in	in	IN
cord-279343-ybncwweg	122	18	the	the	DT
cord-279343-ybncwweg	122	19	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	122	20	-	-	HYPH
cord-279343-ybncwweg	122	21	bound	bind	VBN
cord-279343-ybncwweg	122	22	receptor	receptor	NN
cord-279343-ybncwweg	122	23	,	,	,
cord-279343-ybncwweg	122	24	with	with	IN
cord-279343-ybncwweg	122	25	the	the	DT
cord-279343-ybncwweg	122	26	exception	exception	NN
cord-279343-ybncwweg	122	27	of	of	IN
cord-279343-ybncwweg	122	28	two	two	CD
cord-279343-ybncwweg	122	29	loops	loop	NNS
cord-279343-ybncwweg	122	30	that	that	WDT
cord-279343-ybncwweg	122	31	are	be	VBP
cord-279343-ybncwweg	122	32	involved	involve	VBN
cord-279343-ybncwweg	122	33	in	in	IN
cord-279343-ybncwweg	122	34	the	the	DT
cord-279343-ybncwweg	122	35	coordination	coordination	NN
cord-279343-ybncwweg	122	36	of	of	IN
cord-279343-ybncwweg	122	37	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	122	38	(	(	-LRB-
cord-279343-ybncwweg	122	39	residues	residue	NNS
cord-279343-ybncwweg	122	40	361	361	CD
cord-279343-ybncwweg	122	41	-	-	SYM
cord-279343-ybncwweg	122	42	366	366	CD
cord-279343-ybncwweg	122	43	)	)	-RRB-
cord-279343-ybncwweg	122	44	and	and	CC
cord-279343-ybncwweg	122	45	auxiliary	auxiliary	JJ
cord-279343-ybncwweg	122	46	calcium	calcium	NN
cord-279343-ybncwweg	122	47	ions	ion	NNS
cord-279343-ybncwweg	122	48	(	(	-LRB-
cord-279343-ybncwweg	122	49	residue	residue	NNP
cord-279343-ybncwweg	122	50	332	332	CD
cord-279343-ybncwweg	122	51	-	-	SYM
cord-279343-ybncwweg	122	52	339	339	CD
cord-279343-ybncwweg	122	53	)	)	-RRB-
cord-279343-ybncwweg	122	54	in	in	IN
cord-279343-ybncwweg	122	55	the	the	DT
cord-279343-ybncwweg	122	56	bound	bind	VBN
cord-279343-ybncwweg	122	57	-	-	HYPH
cord-279343-ybncwweg	122	58	form	form	NN
cord-279343-ybncwweg	122	59	.	.	.
cord-279343-ybncwweg	123	1	In	in	IN
cord-279343-ybncwweg	123	2	the	the	DT
cord-279343-ybncwweg	123	3	absence	absence	NN
cord-279343-ybncwweg	123	4	of	of	IN
cord-279343-ybncwweg	123	5	the	the	DT
cord-279343-ybncwweg	123	6	bound	bind	VBN
cord-279343-ybncwweg	123	7	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	123	8	,	,	,
cord-279343-ybncwweg	123	9	both	both	DT
cord-279343-ybncwweg	123	10	loops	loop	NNS
cord-279343-ybncwweg	123	11	adopt	adopt	VBP
cord-279343-ybncwweg	123	12	open	open	JJ
cord-279343-ybncwweg	123	13	conformations	conformation	NNS
cord-279343-ybncwweg	123	14	that	that	WDT
cord-279343-ybncwweg	123	15	are	be	VBP
cord-279343-ybncwweg	123	16	likely	likely	RB
cord-279343-ybncwweg	123	17	attributed	attribute	VBN
cord-279343-ybncwweg	123	18	to	to	IN
cord-279343-ybncwweg	123	19	the	the	DT
cord-279343-ybncwweg	123	20	loss	loss	NN
cord-279343-ybncwweg	123	21	of	of	IN
cord-279343-ybncwweg	123	22	interactions	interaction	NNS
cord-279343-ybncwweg	123	23	with	with	IN
cord-279343-ybncwweg	123	24	the	the	DT
cord-279343-ybncwweg	123	25	putative	putative	JJ
cord-279343-ybncwweg	123	26	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	123	27	and	and	CC
cord-279343-ybncwweg	123	28	calcium	calcium	NN
cord-279343-ybncwweg	123	29	.	.	.
cord-279343-ybncwweg	124	1	The	the	DT
cord-279343-ybncwweg	124	2	absence	absence	NN
cord-279343-ybncwweg	124	3	of	of	IN
cord-279343-ybncwweg	124	4	two	two	CD
cord-279343-ybncwweg	124	5	bound	bind	VBN
cord-279343-ybncwweg	124	6	auxiliary	auxiliary	JJ
cord-279343-ybncwweg	124	7	calcium	calcium	NN
cord-279343-ybncwweg	124	8	ions	ion	NNS
cord-279343-ybncwweg	124	9	compared	compare	VBN
cord-279343-ybncwweg	124	10	with	with	IN
cord-279343-ybncwweg	124	11	the	the	DT
cord-279343-ybncwweg	124	12	structure	structure	NN
cord-279343-ybncwweg	124	13	of	of	IN
cord-279343-ybncwweg	124	14	the	the	DT
cord-279343-ybncwweg	124	15	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	124	16	-	-	HYPH
cord-279343-ybncwweg	124	17	bound	bind	VBN
cord-279343-ybncwweg	124	18	receptor	receptor	NN
cord-279343-ybncwweg	124	19	suggests	suggest	VBZ
cord-279343-ybncwweg	124	20	that	that	IN
cord-279343-ybncwweg	124	21	the	the	DT
cord-279343-ybncwweg	124	22	auxiliary	auxiliary	JJ
cord-279343-ybncwweg	124	23	calcium	calcium	NN
cord-279343-ybncwweg	124	24	sites	site	NNS
cord-279343-ybncwweg	124	25	are	be	VBP
cord-279343-ybncwweg	124	26	of	of	IN
cord-279343-ybncwweg	124	27	low	low	JJ
cord-279343-ybncwweg	124	28	affinity	affinity	NN
cord-279343-ybncwweg	124	29	compared	compare	VBN
cord-279343-ybncwweg	124	30	to	to	IN
cord-279343-ybncwweg	124	31	the	the	DT
cord-279343-ybncwweg	124	32	primary	primary	JJ
cord-279343-ybncwweg	124	33	calcium	calcium	NN
cord-279343-ybncwweg	124	34	site	site	NN
cord-279343-ybncwweg	124	35	,	,	,
cord-279343-ybncwweg	124	36	and	and	CC
cord-279343-ybncwweg	124	37	their	-PRON-	PRP$
cord-279343-ybncwweg	124	38	presence	presence	NN
cord-279343-ybncwweg	124	39	appears	appear	VBZ
cord-279343-ybncwweg	124	40	to	to	TO
cord-279343-ybncwweg	124	41	be	be	VB
cord-279343-ybncwweg	124	42	ligand	ligand	NN
cord-279343-ybncwweg	124	43	-	-	HYPH
cord-279343-ybncwweg	124	44	induced	induce	VBN
cord-279343-ybncwweg	124	45	.	.	.
cord-279343-ybncwweg	125	1	The	the	DT
cord-279343-ybncwweg	125	2	multivalent	multivalent	JJ
cord-279343-ybncwweg	125	3	nature	nature	NN
cord-279343-ybncwweg	125	4	of	of	IN
cord-279343-ybncwweg	125	5	DC	DC	NNP
cord-279343-ybncwweg	125	6	-	-	HYPH
cord-279343-ybncwweg	125	7	SIGN	SIGN	NNP
cord-279343-ybncwweg	125	8	/	/	SYM
cord-279343-ybncwweg	125	9	R	r	NN
cord-279343-ybncwweg	125	10	indicates	indicate	VBZ
cord-279343-ybncwweg	125	11	that	that	IN
cord-279343-ybncwweg	125	12	recognition	recognition	NN
cord-279343-ybncwweg	125	13	of	of	IN
cord-279343-ybncwweg	125	14	small	small	JJ
cord-279343-ybncwweg	125	15	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	125	16	compounds	compound	NNS
cord-279343-ybncwweg	125	17	by	by	IN
cord-279343-ybncwweg	125	18	individual	individual	JJ
cord-279343-ybncwweg	125	19	CRD	crd	NN
cord-279343-ybncwweg	125	20	alone	alone	RB
cord-279343-ybncwweg	125	21	is	be	VBZ
cord-279343-ybncwweg	125	22	not	not	RB
cord-279343-ybncwweg	125	23	sufficient	sufficient	JJ
cord-279343-ybncwweg	125	24	to	to	TO
cord-279343-ybncwweg	125	25	achieve	achieve	VB
cord-279343-ybncwweg	125	26	the	the	DT
cord-279343-ybncwweg	125	27	high	high	JJ
cord-279343-ybncwweg	125	28	-	-	HYPH
cord-279343-ybncwweg	125	29	affinity	affinity	NN
cord-279343-ybncwweg	125	30	interactions	interaction	NNS
cord-279343-ybncwweg	125	31	of	of	IN
cord-279343-ybncwweg	125	32	DC	DC	NNP
cord-279343-ybncwweg	125	33	-	-	HYPH
cord-279343-ybncwweg	125	34	SIGN	SIGN	NNP
cord-279343-ybncwweg	125	35	and	and	CC
cord-279343-ybncwweg	125	36	DC	DC	NNP
cord-279343-ybncwweg	125	37	-	-	HYPH
cord-279343-ybncwweg	125	38	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	125	39	with	with	IN
cord-279343-ybncwweg	125	40	pathogens	pathogen	NNS
cord-279343-ybncwweg	125	41	like	like	IN
cord-279343-ybncwweg	125	42	HIV-1	HIV-1	NNP
cord-279343-ybncwweg	125	43	gp120	gp120	NNP
cord-279343-ybncwweg	125	44	.	.	.
cord-279343-ybncwweg	126	1	The	the	DT
cord-279343-ybncwweg	126	2	functional	functional	JJ
cord-279343-ybncwweg	126	3	receptors	receptor	NNS
cord-279343-ybncwweg	126	4	have	have	VBP
cord-279343-ybncwweg	126	5	been	be	VBN
cord-279343-ybncwweg	126	6	shown	show	VBN
cord-279343-ybncwweg	126	7	to	to	TO
cord-279343-ybncwweg	126	8	be	be	VB
cord-279343-ybncwweg	126	9	tetramers	tetramer	NNS
cord-279343-ybncwweg	126	10	.	.	.
cord-279343-ybncwweg	127	1	17	17	CD
cord-279343-ybncwweg	127	2	,	,	,
cord-279343-ybncwweg	127	3	21	21	CD
cord-279343-ybncwweg	128	1	In	in	IN
cord-279343-ybncwweg	128	2	addition	addition	NN
cord-279343-ybncwweg	128	3	,	,	,
cord-279343-ybncwweg	128	4	biochemical	biochemical	JJ
cord-279343-ybncwweg	128	5	studies	study	NNS
cord-279343-ybncwweg	128	6	with	with	IN
cord-279343-ybncwweg	128	7	repeat	repeat	NN
cord-279343-ybncwweg	128	8	domain	domain	NN
cord-279343-ybncwweg	128	9	deletion	deletion	NN
cord-279343-ybncwweg	128	10	mutants	mutant	NNS
cord-279343-ybncwweg	128	11	have	have	VBP
cord-279343-ybncwweg	128	12	shown	show	VBN
cord-279343-ybncwweg	128	13	that	that	IN
cord-279343-ybncwweg	128	14	a	a	DT
cord-279343-ybncwweg	128	15	minimum	minimum	NN
cord-279343-ybncwweg	128	16	of	of	IN
cord-279343-ybncwweg	128	17	three	three	CD
cord-279343-ybncwweg	128	18	repeats	repeat	NNS
cord-279343-ybncwweg	128	19	are	be	VBP
cord-279343-ybncwweg	128	20	necessary	necessary	JJ
cord-279343-ybncwweg	128	21	to	to	TO
cord-279343-ybncwweg	128	22	form	form	VB
cord-279343-ybncwweg	128	23	tetramers	tetramer	NNS
cord-279343-ybncwweg	128	24	,	,	,
cord-279343-ybncwweg	128	25	with	with	IN
cord-279343-ybncwweg	128	26	additional	additional	JJ
cord-279343-ybncwweg	128	27	repeats	repeat	NNS
cord-279343-ybncwweg	128	28	functioning	function	VBG
cord-279343-ybncwweg	128	29	to	to	TO
cord-279343-ybncwweg	128	30	stabilize	stabilize	VB
cord-279343-ybncwweg	128	31	the	the	DT
cord-279343-ybncwweg	128	32	tetramer	tetramer	NN
cord-279343-ybncwweg	128	33	.	.	.
cord-279343-ybncwweg	129	1	21	21	CD
cord-279343-ybncwweg	130	1	On	on	IN
cord-279343-ybncwweg	130	2	the	the	DT
cord-279343-ybncwweg	130	3	basis	basis	NN
cord-279343-ybncwweg	130	4	of	of	IN
cord-279343-ybncwweg	130	5	the	the	DT
cord-279343-ybncwweg	130	6	current	current	JJ
cord-279343-ybncwweg	130	7	crystal	crystal	NN
cord-279343-ybncwweg	130	8	structures	structure	NNS
cord-279343-ybncwweg	130	9	and	and	CC
cord-279343-ybncwweg	130	10	available	available	JJ
cord-279343-ybncwweg	130	11	biophysical	biophysical	JJ
cord-279343-ybncwweg	130	12	data	datum	NNS
cord-279343-ybncwweg	130	13	,	,	,
cord-279343-ybncwweg	130	14	a	a	DT
cord-279343-ybncwweg	130	15	tetramer	tetramer	NN
cord-279343-ybncwweg	130	16	for	for	IN
cord-279343-ybncwweg	130	17	the	the	DT
cord-279343-ybncwweg	130	18	entire	entire	JJ
cord-279343-ybncwweg	130	19	extracellular	extracellular	JJ
cord-279343-ybncwweg	130	20	DC	DC	NNP
cord-279343-ybncwweg	130	21	-	-	HYPH
cord-279343-ybncwweg	130	22	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	130	23	receptor	receptor	NN
cord-279343-ybncwweg	130	24	was	be	VBD
cord-279343-ybncwweg	130	25	constructed	construct	VBN
cord-279343-ybncwweg	130	26	by	by	IN
cord-279343-ybncwweg	130	27	homology	homology	NN
cord-279343-ybncwweg	130	28	modeling	model	VBG
cord-279343-ybncwweg	130	29	in	in	IN
cord-279343-ybncwweg	130	30	which	which	WDT
cord-279343-ybncwweg	130	31	the	the	DT
cord-279343-ybncwweg	130	32	repeat	repeat	NN
cord-279343-ybncwweg	130	33	regions	region	NNS
cord-279343-ybncwweg	130	34	form	form	VBP
cord-279343-ybncwweg	130	35	helical	helical	JJ
cord-279343-ybncwweg	130	36	bundles	bundle	NNS
cord-279343-ybncwweg	130	37	to	to	TO
cord-279343-ybncwweg	130	38	bring	bring	VB
cord-279343-ybncwweg	130	39	together	together	RB
cord-279343-ybncwweg	130	40	their	-PRON-	PRP$
cord-279343-ybncwweg	130	41	CRDs	crd	NNS
cord-279343-ybncwweg	130	42	in	in	IN
cord-279343-ybncwweg	130	43	a	a	DT
cord-279343-ybncwweg	130	44	4-fold	4-fold	RB
cord-279343-ybncwweg	130	45	related	related	JJ
cord-279343-ybncwweg	130	46	symmetry	symmetry	NN
cord-279343-ybncwweg	130	47	.	.	.
cord-279343-ybncwweg	131	1	This	this	DT
cord-279343-ybncwweg	131	2	helical	helical	JJ
cord-279343-ybncwweg	131	3	bundle	bundle	NN
cord-279343-ybncwweg	131	4	-	-	HYPH
cord-279343-ybncwweg	131	5	mediated	mediate	VBN
cord-279343-ybncwweg	131	6	oligomerization	oligomerization	NN
cord-279343-ybncwweg	131	7	resembles	resemble	VBZ
cord-279343-ybncwweg	131	8	superficially	superficially	RB
cord-279343-ybncwweg	131	9	the	the	DT
cord-279343-ybncwweg	131	10	trimer	trimer	NN
cord-279343-ybncwweg	131	11	of	of	IN
cord-279343-ybncwweg	131	12	rat	rat	NN
cord-279343-ybncwweg	131	13	mannose	mannose	NN
cord-279343-ybncwweg	131	14	-	-	HYPH
cord-279343-ybncwweg	131	15	binding	bind	VBG
cord-279343-ybncwweg	131	16	protein	protein	NN
cord-279343-ybncwweg	131	17	.	.	.
cord-279343-ybncwweg	132	1	20	20	CD
cord-279343-ybncwweg	133	1	While	while	IN
cord-279343-ybncwweg	133	2	the	the	DT
cord-279343-ybncwweg	133	3	receptor	receptor	NN
cord-279343-ybncwweg	133	4	repeat	repeat	NN
cord-279343-ybncwweg	133	5	domain	domain	NN
cord-279343-ybncwweg	133	6	is	be	VBZ
cord-279343-ybncwweg	133	7	conserved	conserve	VBN
cord-279343-ybncwweg	133	8	in	in	IN
cord-279343-ybncwweg	133	9	most	most	JJS
cord-279343-ybncwweg	133	10	species	specie	NNS
cord-279343-ybncwweg	133	11	,	,	,
cord-279343-ybncwweg	133	12	a	a	DT
cord-279343-ybncwweg	133	13	notable	notable	JJ
cord-279343-ybncwweg	133	14	exception	exception	NN
cord-279343-ybncwweg	133	15	is	be	VBZ
cord-279343-ybncwweg	133	16	that	that	DT
cord-279343-ybncwweg	133	17	of	of	IN
cord-279343-ybncwweg	133	18	Old	Old	NNP
cord-279343-ybncwweg	133	19	World	World	NNP
cord-279343-ybncwweg	133	20	Rhesus	Rhesus	NNP
cord-279343-ybncwweg	133	21	monkey	monkey	NN
cord-279343-ybncwweg	133	22	,	,	,
cord-279343-ybncwweg	133	23	whose	whose	WP$
cord-279343-ybncwweg	133	24	DC	DC	NNP
cord-279343-ybncwweg	133	25	-	-	HYPH
cord-279343-ybncwweg	133	26	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	133	27	gene	gene	NN
cord-279343-ybncwweg	133	28	(	(	-LRB-
cord-279343-ybncwweg	133	29	CD209L2	CD209L2	NNP
cord-279343-ybncwweg	133	30	)	)	-RRB-
cord-279343-ybncwweg	133	31	is	be	VBZ
cord-279343-ybncwweg	133	32	missing	miss	VBG
cord-279343-ybncwweg	133	33	all	all	PDT
cord-279343-ybncwweg	133	34	the	the	DT
cord-279343-ybncwweg	133	35	repeats	repeat	NNS
cord-279343-ybncwweg	133	36	and	and	CC
cord-279343-ybncwweg	133	37	DC	DC	NNP
cord-279343-ybncwweg	133	38	-	-	HYPH
cord-279343-ybncwweg	133	39	SIGN	sign	NN
cord-279343-ybncwweg	133	40	gene	gene	NN
cord-279343-ybncwweg	133	41	is	be	VBZ
cord-279343-ybncwweg	133	42	missing	miss	VBG
cord-279343-ybncwweg	133	43	the	the	DT
cord-279343-ybncwweg	133	44	fourth	fourth	JJ
cord-279343-ybncwweg	133	45	repeat	repeat	NN
cord-279343-ybncwweg	133	46	.	.	.
cord-279343-ybncwweg	134	1	27	27	CD
cord-279343-ybncwweg	134	2	CD209L2	CD209L2	NNP
cord-279343-ybncwweg	134	3	is	be	VBZ
cord-279343-ybncwweg	134	4	predicted	predict	VBN
cord-279343-ybncwweg	134	5	to	to	TO
cord-279343-ybncwweg	134	6	be	be	VB
cord-279343-ybncwweg	134	7	a	a	DT
cord-279343-ybncwweg	134	8	monomer	monomer	NN
cord-279343-ybncwweg	134	9	and	and	CC
cord-279343-ybncwweg	134	10	has	have	VBZ
cord-279343-ybncwweg	134	11	been	be	VBN
cord-279343-ybncwweg	134	12	shown	show	VBN
cord-279343-ybncwweg	134	13	to	to	TO
cord-279343-ybncwweg	134	14	be	be	VB
cord-279343-ybncwweg	134	15	less	less	RBR
cord-279343-ybncwweg	134	16	efficient	efficient	JJ
cord-279343-ybncwweg	134	17	in	in	IN
cord-279343-ybncwweg	134	18	binding	bind	VBG
cord-279343-ybncwweg	134	19	to	to	IN
cord-279343-ybncwweg	134	20	both	both	CC
cord-279343-ybncwweg	134	21	ICAM-3	ICAM-3	NNP
cord-279343-ybncwweg	134	22	and	and	CC
cord-279343-ybncwweg	134	23	HIV	HIV	NNP
cord-279343-ybncwweg	134	24	gp120	gp120	NNP
cord-279343-ybncwweg	134	25	.	.	.
cord-279343-ybncwweg	135	1	The	the	DT
cord-279343-ybncwweg	135	2	fourth	fourth	JJ
cord-279343-ybncwweg	135	3	repeat	repeat	NN
cord-279343-ybncwweg	135	4	in	in	IN
cord-279343-ybncwweg	135	5	our	-PRON-	PRP$
cord-279343-ybncwweg	135	6	model	model	NN
cord-279343-ybncwweg	135	7	serves	serve	VBZ
cord-279343-ybncwweg	135	8	as	as	IN
cord-279343-ybncwweg	135	9	a	a	DT
cord-279343-ybncwweg	135	10	connecting	connect	VBG
cord-279343-ybncwweg	135	11	helix	helix	NN
cord-279343-ybncwweg	135	12	between	between	IN
cord-279343-ybncwweg	135	13	the	the	DT
cord-279343-ybncwweg	135	14	two	two	CD
cord-279343-ybncwweg	135	15	helical	helical	JJ
cord-279343-ybncwweg	135	16	bundles	bundle	NNS
cord-279343-ybncwweg	135	17	.	.	.
cord-279343-ybncwweg	136	1	Deletion	deletion	NN
cord-279343-ybncwweg	136	2	of	of	IN
cord-279343-ybncwweg	136	3	this	this	DT
cord-279343-ybncwweg	136	4	repeat	repeat	NN
cord-279343-ybncwweg	136	5	would	would	MD
cord-279343-ybncwweg	136	6	most	most	RBS
cord-279343-ybncwweg	136	7	likely	likely	RB
cord-279343-ybncwweg	136	8	shorten	shorten	VB
cord-279343-ybncwweg	136	9	this	this	DT
cord-279343-ybncwweg	136	10	connecting	connect	VBG
cord-279343-ybncwweg	136	11	helix	helix	NN
cord-279343-ybncwweg	136	12	but	but	CC
cord-279343-ybncwweg	136	13	may	may	MD
cord-279343-ybncwweg	136	14	not	not	RB
cord-279343-ybncwweg	136	15	affect	affect	VB
cord-279343-ybncwweg	136	16	the	the	DT
cord-279343-ybncwweg	136	17	formation	formation	NN
cord-279343-ybncwweg	136	18	of	of	IN
cord-279343-ybncwweg	136	19	the	the	DT
cord-279343-ybncwweg	136	20	helical	helical	JJ
cord-279343-ybncwweg	136	21	bundles	bundle	NNS
cord-279343-ybncwweg	136	22	(	(	-LRB-
cord-279343-ybncwweg	136	23	R6-R8	R6-R8	NNP
cord-279343-ybncwweg	136	24	and	and	CC
cord-279343-ybncwweg	136	25	R1-R3	R1-R3	NNP
cord-279343-ybncwweg	136	26	)	)	-RRB-
cord-279343-ybncwweg	136	27	.	.	.
cord-279343-ybncwweg	137	1	The	the	DT
cord-279343-ybncwweg	137	2	results	result	NNS
cord-279343-ybncwweg	137	3	of	of	IN
cord-279343-ybncwweg	137	4	trypsin	trypsin	JJ
cord-279343-ybncwweg	137	5	digestion	digestion	NN
cord-279343-ybncwweg	137	6	studies	study	NNS
cord-279343-ybncwweg	137	7	appear	appear	VBP
cord-279343-ybncwweg	137	8	to	to	TO
cord-279343-ybncwweg	137	9	support	support	VB
cord-279343-ybncwweg	137	10	a	a	DT
cord-279343-ybncwweg	137	11	model	model	NN
cord-279343-ybncwweg	137	12	in	in	IN
cord-279343-ybncwweg	137	13	which	which	WDT
cord-279343-ybncwweg	137	14	the	the	DT
cord-279343-ybncwweg	137	15	helical	helical	JJ
cord-279343-ybncwweg	137	16	repeats	repeat	NNS
cord-279343-ybncwweg	137	17	are	be	VBP
cord-279343-ybncwweg	137	18	protected	protect	VBN
cord-279343-ybncwweg	137	19	from	from	IN
cord-279343-ybncwweg	137	20	protease	protease	NN
cord-279343-ybncwweg	137	21	by	by	IN
cord-279343-ybncwweg	137	22	forming	form	VBG
cord-279343-ybncwweg	137	23	tightly	tightly	RB
cord-279343-ybncwweg	137	24	packed	pack	VBN
cord-279343-ybncwweg	137	25	helical	helical	JJ
cord-279343-ybncwweg	137	26	bundles	bundle	NNS
cord-279343-ybncwweg	137	27	rather	rather	RB
cord-279343-ybncwweg	137	28	than	than	IN
cord-279343-ybncwweg	137	29	by	by	IN
cord-279343-ybncwweg	137	30	forming	form	VBG
cord-279343-ybncwweg	137	31	a	a	DT
cord-279343-ybncwweg	137	32	single	single	JJ
cord-279343-ybncwweg	137	33	elongated	elongated	JJ
cord-279343-ybncwweg	137	34	helical	helical	JJ
cord-279343-ybncwweg	137	35	domain	domain	NN
cord-279343-ybncwweg	137	36	(	(	-LRB-
cord-279343-ybncwweg	137	37	Figure	figure	NN
cord-279343-ybncwweg	137	38	4	4	CD
cord-279343-ybncwweg	137	39	)	)	-RRB-
cord-279343-ybncwweg	137	40	.	.	.
cord-279343-ybncwweg	138	1	Using	use	VBG
cord-279343-ybncwweg	138	2	this	this	DT
cord-279343-ybncwweg	138	3	DC	DC	NNP
cord-279343-ybncwweg	138	4	-	-	HYPH
cord-279343-ybncwweg	138	5	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	138	6	tetramer	tetramer	NN
cord-279343-ybncwweg	138	7	model	model	NN
cord-279343-ybncwweg	138	8	and	and	CC
cord-279343-ybncwweg	138	9	the	the	DT
cord-279343-ybncwweg	138	10	assumption	assumption	NN
cord-279343-ybncwweg	138	11	that	that	IN
cord-279343-ybncwweg	138	12	high	high	JJ
cord-279343-ybncwweg	138	13	-	-	HYPH
cord-279343-ybncwweg	138	14	affinity	affinity	NN
cord-279343-ybncwweg	138	15	ligand	ligand	NN
cord-279343-ybncwweg	138	16	binding	binding	NN
cord-279343-ybncwweg	138	17	requires	require	VBZ
cord-279343-ybncwweg	138	18	simultaneous	simultaneous	JJ
cord-279343-ybncwweg	138	19	engagement	engagement	NN
cord-279343-ybncwweg	138	20	of	of	IN
cord-279343-ybncwweg	138	21	multiple	multiple	JJ
cord-279343-ybncwweg	138	22	CRD	crd	NN
cord-279343-ybncwweg	138	23	of	of	IN
cord-279343-ybncwweg	138	24	the	the	DT
cord-279343-ybncwweg	138	25	tetrameric	tetrameric	JJ
cord-279343-ybncwweg	138	26	receptor	receptor	NN
cord-279343-ybncwweg	138	27	,	,	,
cord-279343-ybncwweg	138	28	we	-PRON-	PRP
cord-279343-ybncwweg	138	29	formulated	formulate	VBD
cord-279343-ybncwweg	138	30	a	a	DT
cord-279343-ybncwweg	138	31	prediction	prediction	NN
cord-279343-ybncwweg	138	32	scheme	scheme	NN
cord-279343-ybncwweg	138	33	for	for	IN
cord-279343-ybncwweg	138	34	potential	potential	JJ
cord-279343-ybncwweg	138	35	ligands	ligand	NNS
cord-279343-ybncwweg	138	36	of	of	IN
cord-279343-ybncwweg	138	37	DC	DC	NNP
cord-279343-ybncwweg	138	38	-	-	HYPH
cord-279343-ybncwweg	138	39	SIGN	SIGN	NNP
cord-279343-ybncwweg	138	40	/	/	SYM
cord-279343-ybncwweg	138	41	R	r	NN
cord-279343-ybncwweg	138	42	based	base	VBN
cord-279343-ybncwweg	138	43	on	on	IN
cord-279343-ybncwweg	138	44	their	-PRON-	PRP$
cord-279343-ybncwweg	138	45	predicted	predict	VBN
cord-279343-ybncwweg	138	46	gross	gross	JJ
cord-279343-ybncwweg	138	47	glycosylation	glycosylation	NN
cord-279343-ybncwweg	138	48	density	density	NN
cord-279343-ybncwweg	138	49	.	.	.
cord-279343-ybncwweg	139	1	The	the	DT
cord-279343-ybncwweg	139	2	results	result	NNS
cord-279343-ybncwweg	139	3	show	show	VBP
cord-279343-ybncwweg	139	4	that	that	IN
cord-279343-ybncwweg	139	5	several	several	JJ
cord-279343-ybncwweg	139	6	viral	viral	JJ
cord-279343-ybncwweg	139	7	envelope	envelope	NN
cord-279343-ybncwweg	139	8	glycoproteins	glycoprotein	NNS
cord-279343-ybncwweg	139	9	,	,	,
cord-279343-ybncwweg	139	10	including	include	VBG
cord-279343-ybncwweg	139	11	HIV-1	HIV-1	NNP
cord-279343-ybncwweg	139	12	gp120	gp120	NNP
cord-279343-ybncwweg	139	13	,	,	,
cord-279343-ybncwweg	139	14	Marburg	Marburg	NNP
cord-279343-ybncwweg	139	15	virus	virus	NN
cord-279343-ybncwweg	139	16	GP	gp	NN
cord-279343-ybncwweg	139	17	,	,	,
cord-279343-ybncwweg	139	18	coronavirus	coronavirus	NN
cord-279343-ybncwweg	139	19	spike	spike	NN
cord-279343-ybncwweg	139	20	protein	protein	NN
cord-279343-ybncwweg	139	21	,	,	,
cord-279343-ybncwweg	139	22	and	and	CC
cord-279343-ybncwweg	139	23	HRSV	HRSV	NNP
cord-279343-ybncwweg	139	24	glycoprotein	glycoprotein	NN
cord-279343-ybncwweg	139	25	G	g	NN
cord-279343-ybncwweg	139	26	,	,	,
cord-279343-ybncwweg	139	27	possess	possess	VBP
cord-279343-ybncwweg	139	28	high	high	JJ
cord-279343-ybncwweg	139	29	ligand	ligand	NN
cord-279343-ybncwweg	139	30	indices	index	NNS
cord-279343-ybncwweg	139	31	.	.	.
cord-279343-ybncwweg	140	1	Among	among	IN
cord-279343-ybncwweg	140	2	them	-PRON-	PRP
cord-279343-ybncwweg	140	3	,	,	,
cord-279343-ybncwweg	140	4	gp120	gp120	CD
cord-279343-ybncwweg	140	5	of	of	IN
cord-279343-ybncwweg	140	6	HIV	HIV	NNP
cord-279343-ybncwweg	140	7	,	,	,
cord-279343-ybncwweg	140	8	GP	GP	NNP
cord-279343-ybncwweg	140	9	of	of	IN
cord-279343-ybncwweg	140	10	Ebola	Ebola	NNP
cord-279343-ybncwweg	140	11	,	,	,
cord-279343-ybncwweg	140	12	and	and	CC
cord-279343-ybncwweg	140	13	the	the	DT
cord-279343-ybncwweg	140	14	spike	spike	NN
cord-279343-ybncwweg	140	15	protein	protein	NN
cord-279343-ybncwweg	140	16	of	of	IN
cord-279343-ybncwweg	140	17	coronavirus	coronavirus	NN
cord-279343-ybncwweg	140	18	are	be	VBP
cord-279343-ybncwweg	140	19	known	know	VBN
cord-279343-ybncwweg	140	20	ligands	ligand	NNS
cord-279343-ybncwweg	140	21	of	of	IN
cord-279343-ybncwweg	140	22	DC	DC	NNP
cord-279343-ybncwweg	140	23	-	-	HYPH
cord-279343-ybncwweg	140	24	SIGN	SIGN	NNP
cord-279343-ybncwweg	140	25	.	.	.
cord-279343-ybncwweg	141	1	Of	of	IN
cord-279343-ybncwweg	141	2	the	the	DT
cord-279343-ybncwweg	141	3	potential	potential	JJ
cord-279343-ybncwweg	141	4	cellular	cellular	JJ
cord-279343-ybncwweg	141	5	targets	target	NNS
cord-279343-ybncwweg	141	6	,	,	,
cord-279343-ybncwweg	141	7	in	in	IN
cord-279343-ybncwweg	141	8	addition	addition	NN
cord-279343-ybncwweg	141	9	to	to	IN
cord-279343-ybncwweg	141	10	the	the	DT
cord-279343-ybncwweg	141	11	known	know	VBN
cord-279343-ybncwweg	141	12	ICAM-3	icam-3	JJ
cord-279343-ybncwweg	141	13	ligand	ligand	NN
cord-279343-ybncwweg	141	14	,	,	,
cord-279343-ybncwweg	141	15	mucins	mucin	NNS
cord-279343-ybncwweg	141	16	are	be	VBP
cord-279343-ybncwweg	141	17	notably	notably	RB
cord-279343-ybncwweg	141	18	ranked	rank	VBN
cord-279343-ybncwweg	141	19	high	high	RB
cord-279343-ybncwweg	141	20	in	in	IN
cord-279343-ybncwweg	141	21	our	-PRON-	PRP$
cord-279343-ybncwweg	141	22	scoring	scoring	NN
cord-279343-ybncwweg	141	23	scheme	scheme	NN
cord-279343-ybncwweg	141	24	.	.	.
cord-279343-ybncwweg	142	1	The	the	DT
cord-279343-ybncwweg	142	2	low	low	RB
cord-279343-ybncwweg	142	3	-	-	HYPH
cord-279343-ybncwweg	142	4	scoring	score	VBG
cord-279343-ybncwweg	142	5	molecules	molecule	NNS
cord-279343-ybncwweg	142	6	,	,	,
cord-279343-ybncwweg	142	7	such	such	JJ
cord-279343-ybncwweg	142	8	as	as	IN
cord-279343-ybncwweg	142	9	IgG	igg	NN
cord-279343-ybncwweg	142	10	,	,	,
cord-279343-ybncwweg	142	11	KIR2DL2	KIR2DL2	NNP
cord-279343-ybncwweg	142	12	and	and	CC
cord-279343-ybncwweg	142	13	HLA	HLA	NNP
cord-279343-ybncwweg	142	14	-	-	HYPH
cord-279343-ybncwweg	142	15	CW3	CW3	NNP
cord-279343-ybncwweg	142	16	did	do	VBD
cord-279343-ybncwweg	142	17	not	not	RB
cord-279343-ybncwweg	142	18	exhibit	exhibit	VB
cord-279343-ybncwweg	142	19	binding	bind	VBG
cord-279343-ybncwweg	142	20	to	to	IN
cord-279343-ybncwweg	142	21	DC	DC	NNP
cord-279343-ybncwweg	142	22	-	-	HYPH
cord-279343-ybncwweg	142	23	SIGN	sign	NN
cord-279343-ybncwweg	142	24	/	/	SYM
cord-279343-ybncwweg	142	25	R	r	NN
cord-279343-ybncwweg	142	26	(	(	-LRB-
cord-279343-ybncwweg	142	27	data	datum	NNS
cord-279343-ybncwweg	142	28	not	not	RB
cord-279343-ybncwweg	142	29	shown	show	VBN
cord-279343-ybncwweg	142	30	)	)	-RRB-
cord-279343-ybncwweg	142	31	.	.	.
cord-279343-ybncwweg	143	1	It	-PRON-	PRP
cord-279343-ybncwweg	143	2	should	should	MD
cord-279343-ybncwweg	143	3	be	be	VB
cord-279343-ybncwweg	143	4	noted	note	VBN
cord-279343-ybncwweg	143	5	that	that	IN
cord-279343-ybncwweg	143	6	the	the	DT
cord-279343-ybncwweg	143	7	receptor	receptor	NN
cord-279343-ybncwweg	143	8	-	-	HYPH
cord-279343-ybncwweg	143	9	ligand	ligand	NN
cord-279343-ybncwweg	143	10	binding	binding	NN
cord-279343-ybncwweg	143	11	will	will	MD
cord-279343-ybncwweg	143	12	also	also	RB
cord-279343-ybncwweg	143	13	depend	depend	VB
cord-279343-ybncwweg	143	14	on	on	IN
cord-279343-ybncwweg	143	15	the	the	DT
cord-279343-ybncwweg	143	16	geometrical	geometrical	JJ
cord-279343-ybncwweg	143	17	constraint	constraint	NN
cord-279343-ybncwweg	143	18	,	,	,
cord-279343-ybncwweg	143	19	including	include	VBG
cord-279343-ybncwweg	143	20	the	the	DT
cord-279343-ybncwweg	143	21	distance	distance	NN
cord-279343-ybncwweg	143	22	between	between	IN
cord-279343-ybncwweg	143	23	and	and	CC
cord-279343-ybncwweg	143	24	the	the	DT
cord-279343-ybncwweg	143	25	orientation	orientation	NN
cord-279343-ybncwweg	143	26	of	of	IN
cord-279343-ybncwweg	143	27	the	the	DT
cord-279343-ybncwweg	143	28	CRDs	crd	NNS
cord-279343-ybncwweg	143	29	.	.	.
cord-279343-ybncwweg	144	1	The	the	DT
cord-279343-ybncwweg	144	2	distance	distance	NN
cord-279343-ybncwweg	144	3	between	between	IN
cord-279343-ybncwweg	144	4	glycans	glycan	NNS
cord-279343-ybncwweg	144	5	,	,	,
cord-279343-ybncwweg	144	6	in	in	IN
cord-279343-ybncwweg	144	7	general	general	JJ
cord-279343-ybncwweg	144	8	,	,	,
cord-279343-ybncwweg	144	9	should	should	MD
cord-279343-ybncwweg	144	10	correlate	correlate	VB
cord-279343-ybncwweg	144	11	with	with	IN
cord-279343-ybncwweg	144	12	their	-PRON-	PRP$
cord-279343-ybncwweg	144	13	surface	surface	NN
cord-279343-ybncwweg	144	14	density	density	NN
cord-279343-ybncwweg	144	15	.	.	.
cord-279343-ybncwweg	145	1	Situations	situation	NNS
cord-279343-ybncwweg	145	2	in	in	IN
cord-279343-ybncwweg	145	3	which	which	WDT
cord-279343-ybncwweg	145	4	local	local	JJ
cord-279343-ybncwweg	145	5	spacing	spacing	NN
cord-279343-ybncwweg	145	6	variation	variation	NN
cord-279343-ybncwweg	145	7	resulting	result	VBG
cord-279343-ybncwweg	145	8	in	in	IN
cord-279343-ybncwweg	145	9	the	the	DT
cord-279343-ybncwweg	145	10	distance	distance	NN
cord-279343-ybncwweg	145	11	between	between	IN
cord-279343-ybncwweg	145	12	glycans	glycan	NNS
cord-279343-ybncwweg	145	13	either	either	CC
cord-279343-ybncwweg	145	14	too	too	RB
cord-279343-ybncwweg	145	15	close	close	JJ
cord-279343-ybncwweg	145	16	or	or	CC
cord-279343-ybncwweg	145	17	too	too	RB
cord-279343-ybncwweg	145	18	far	far	RB
cord-279343-ybncwweg	145	19	apart	apart	RB
cord-279343-ybncwweg	145	20	to	to	TO
cord-279343-ybncwweg	145	21	simultaneously	simultaneously	RB
cord-279343-ybncwweg	145	22	engage	engage	VB
cord-279343-ybncwweg	145	23	the	the	DT
cord-279343-ybncwweg	145	24	multimeric	multimeric	JJ
cord-279343-ybncwweg	145	25	CRD	CRD	NNP
cord-279343-ybncwweg	145	26	would	would	MD
cord-279343-ybncwweg	145	27	clearly	clearly	RB
cord-279343-ybncwweg	145	28	affect	affect	VB
cord-279343-ybncwweg	145	29	the	the	DT
cord-279343-ybncwweg	145	30	recognition	recognition	NN
cord-279343-ybncwweg	145	31	by	by	IN
cord-279343-ybncwweg	145	32	the	the	DT
cord-279343-ybncwweg	145	33	receptor	receptor	NN
cord-279343-ybncwweg	145	34	.	.	.
cord-279343-ybncwweg	146	1	Nevertheless	nevertheless	RB
cord-279343-ybncwweg	146	2	,	,	,
cord-279343-ybncwweg	146	3	the	the	DT
cord-279343-ybncwweg	146	4	known	know	VBN
cord-279343-ybncwweg	146	5	flexibility	flexibility	NN
cord-279343-ybncwweg	146	6	of	of	IN
cord-279343-ybncwweg	146	7	glycans	glycan	NNS
cord-279343-ybncwweg	146	8	and	and	CC
cord-279343-ybncwweg	146	9	the	the	DT
cord-279343-ybncwweg	146	10	observed	observed	JJ
cord-279343-ybncwweg	146	11	variation	variation	NN
cord-279343-ybncwweg	146	12	in	in	IN
cord-279343-ybncwweg	146	13	the	the	DT
cord-279343-ybncwweg	146	14	hinge	hinge	NN
cord-279343-ybncwweg	146	15	angle	angle	NN
cord-279343-ybncwweg	146	16	between	between	IN
cord-279343-ybncwweg	146	17	the	the	DT
cord-279343-ybncwweg	146	18	receptor	receptor	NN
cord-279343-ybncwweg	146	19	CRD	crd	NN
cord-279343-ybncwweg	146	20	and	and	CC
cord-279343-ybncwweg	146	21	repeat	repeat	NN
cord-279343-ybncwweg	146	22	domains	domain	NNS
cord-279343-ybncwweg	146	23	of	of	IN
cord-279343-ybncwweg	146	24	DC	DC	NNP
cord-279343-ybncwweg	146	25	-	-	HYPH
cord-279343-ybncwweg	146	26	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	146	27	illustrate	illustrate	VBP
cord-279343-ybncwweg	146	28	the	the	DT
cord-279343-ybncwweg	146	29	built	build	VBN
cord-279343-ybncwweg	146	30	-	-	HYPH
cord-279343-ybncwweg	146	31	in	in	RP
cord-279343-ybncwweg	146	32	flexibilities	flexibility	NNS
cord-279343-ybncwweg	146	33	in	in	IN
cord-279343-ybncwweg	146	34	both	both	CC
cord-279343-ybncwweg	146	35	the	the	DT
cord-279343-ybncwweg	146	36	receptor	receptor	NN
cord-279343-ybncwweg	146	37	and	and	CC
cord-279343-ybncwweg	146	38	ligands	ligand	NNS
cord-279343-ybncwweg	146	39	,	,	,
cord-279343-ybncwweg	146	40	and	and	CC
cord-279343-ybncwweg	146	41	thus	thus	RB
cord-279343-ybncwweg	146	42	lend	lend	VB
cord-279343-ybncwweg	146	43	some	some	DT
cord-279343-ybncwweg	146	44	degree	degree	NN
cord-279343-ybncwweg	146	45	of	of	IN
cord-279343-ybncwweg	146	46	freedom	freedom	NN
cord-279343-ybncwweg	146	47	to	to	IN
cord-279343-ybncwweg	146	48	the	the	DT
cord-279343-ybncwweg	146	49	receptor	receptor	NN
cord-279343-ybncwweg	146	50	-	-	HYPH
cord-279343-ybncwweg	146	51	ligand	ligand	NN
cord-279343-ybncwweg	146	52	recognition	recognition	NN
cord-279343-ybncwweg	146	53	.	.	.
cord-279343-ybncwweg	147	1	These	these	DT
cord-279343-ybncwweg	147	2	intrinsic	intrinsic	JJ
cord-279343-ybncwweg	147	3	flexibilities	flexibility	NNS
cord-279343-ybncwweg	147	4	would	would	MD
cord-279343-ybncwweg	147	5	lead	lead	VB
cord-279343-ybncwweg	147	6	to	to	IN
cord-279343-ybncwweg	147	7	greater	great	JJR
cord-279343-ybncwweg	147	8	variability	variability	NN
cord-279343-ybncwweg	147	9	in	in	IN
cord-279343-ybncwweg	147	10	distance	distance	NN
cord-279343-ybncwweg	147	11	and	and	CC
cord-279343-ybncwweg	147	12	orientation	orientation	NN
cord-279343-ybncwweg	147	13	,	,	,
cord-279343-ybncwweg	147	14	and	and	CC
cord-279343-ybncwweg	147	15	marginalize	marginalize	VB
cord-279343-ybncwweg	147	16	the	the	DT
cord-279343-ybncwweg	147	17	geometric	geometric	JJ
cord-279343-ybncwweg	147	18	constraint	constraint	NN
cord-279343-ybncwweg	147	19	.	.	.
cord-279343-ybncwweg	148	1	Nonetheless	nonetheless	RB
cord-279343-ybncwweg	148	2	,	,	,
cord-279343-ybncwweg	148	3	the	the	DT
cord-279343-ybncwweg	148	4	most	most	RBS
cord-279343-ybncwweg	148	5	obvious	obvious	JJ
cord-279343-ybncwweg	148	6	reasons	reason	NNS
cord-279343-ybncwweg	148	7	to	to	TO
cord-279343-ybncwweg	148	8	use	use	VB
cord-279343-ybncwweg	148	9	the	the	DT
cord-279343-ybncwweg	148	10	surface	surface	NN
cord-279343-ybncwweg	148	11	area	area	NN
cord-279343-ybncwweg	148	12	of	of	IN
cord-279343-ybncwweg	148	13	CRD	CRD	NNP
cord-279343-ybncwweg	148	14	instead	instead	RB
cord-279343-ybncwweg	148	15	of	of	IN
cord-279343-ybncwweg	148	16	the	the	DT
cord-279343-ybncwweg	148	17	distance	distance	NN
cord-279343-ybncwweg	148	18	are	be	VBP
cord-279343-ybncwweg	148	19	(	(	-LRB-
cord-279343-ybncwweg	148	20	1	1	CD
cord-279343-ybncwweg	148	21	)	)	-RRB-
cord-279343-ybncwweg	148	22	to	to	TO
cord-279343-ybncwweg	148	23	enable	enable	VB
cord-279343-ybncwweg	148	24	us	-PRON-	PRP
cord-279343-ybncwweg	148	25	to	to	TO
cord-279343-ybncwweg	148	26	derive	derive	VB
cord-279343-ybncwweg	148	27	a	a	DT
cord-279343-ybncwweg	148	28	prediction	prediction	NN
cord-279343-ybncwweg	148	29	scheme	scheme	NN
cord-279343-ybncwweg	148	30	based	base	VBN
cord-279343-ybncwweg	148	31	on	on	IN
cord-279343-ybncwweg	148	32	surface	surface	NN
cord-279343-ybncwweg	148	33	glycan	glycan	NN
cord-279343-ybncwweg	148	34	density	density	NN
cord-279343-ybncwweg	148	35	of	of	IN
cord-279343-ybncwweg	148	36	a	a	DT
cord-279343-ybncwweg	148	37	potential	potential	JJ
cord-279343-ybncwweg	148	38	ligand	ligand	NN
cord-279343-ybncwweg	148	39	,	,	,
cord-279343-ybncwweg	148	40	and	and	CC
cord-279343-ybncwweg	148	41	(	(	-LRB-
cord-279343-ybncwweg	148	42	2	2	LS
cord-279343-ybncwweg	148	43	)	)	-RRB-
cord-279343-ybncwweg	148	44	to	to	TO
cord-279343-ybncwweg	148	45	have	have	VB
cord-279343-ybncwweg	148	46	the	the	DT
cord-279343-ybncwweg	148	47	prediction	prediction	NN
cord-279343-ybncwweg	148	48	less	less	RBR
cord-279343-ybncwweg	148	49	dependent	dependent	JJ
cord-279343-ybncwweg	148	50	on	on	IN
cord-279343-ybncwweg	148	51	the	the	DT
cord-279343-ybncwweg	148	52	precise	precise	JJ
cord-279343-ybncwweg	148	53	conformation	conformation	NN
cord-279343-ybncwweg	148	54	,	,	,
cord-279343-ybncwweg	148	55	thus	thus	RB
cord-279343-ybncwweg	148	56	,	,	,
cord-279343-ybncwweg	148	57	the	the	DT
cord-279343-ybncwweg	148	58	degree	degree	NN
cord-279343-ybncwweg	148	59	of	of	IN
cord-279343-ybncwweg	148	60	correctness	correctness	NN
cord-279343-ybncwweg	148	61	,	,	,
cord-279343-ybncwweg	148	62	of	of	IN
cord-279343-ybncwweg	148	63	the	the	DT
cord-279343-ybncwweg	148	64	tetramer	tetramer	NN
cord-279343-ybncwweg	148	65	model	model	NN
cord-279343-ybncwweg	148	66	.	.	.
cord-279343-ybncwweg	149	1	In	in	IN
cord-279343-ybncwweg	149	2	addition	addition	NN
cord-279343-ybncwweg	149	3	,	,	,
cord-279343-ybncwweg	149	4	equation	equation	NN
cord-279343-ybncwweg	149	5	(	(	-LRB-
cord-279343-ybncwweg	149	6	1	1	CD
cord-279343-ybncwweg	149	7	)	)	-RRB-
cord-279343-ybncwweg	149	8	assumes	assume	VBZ
cord-279343-ybncwweg	149	9	a	a	DT
cord-279343-ybncwweg	149	10	globular	globular	JJ
cord-279343-ybncwweg	149	11	shape	shape	NN
cord-279343-ybncwweg	149	12	for	for	IN
cord-279343-ybncwweg	149	13	proteins	protein	NNS
cord-279343-ybncwweg	149	14	and	and	CC
cord-279343-ybncwweg	149	15	a	a	DT
cord-279343-ybncwweg	149	16	uniform	uniform	JJ
cord-279343-ybncwweg	149	17	distribution	distribution	NN
cord-279343-ybncwweg	149	18	of	of	IN
cord-279343-ybncwweg	149	19	their	-PRON-	PRP$
cord-279343-ybncwweg	149	20	glycosylation	glycosylation	NN
cord-279343-ybncwweg	149	21	.	.	.
cord-279343-ybncwweg	150	1	Clearly	clearly	RB
cord-279343-ybncwweg	150	2	,	,	,
cord-279343-ybncwweg	150	3	both	both	CC
cord-279343-ybncwweg	150	4	the	the	DT
cord-279343-ybncwweg	150	5	local	local	JJ
cord-279343-ybncwweg	150	6	distribution	distribution	NN
cord-279343-ybncwweg	150	7	of	of	IN
cord-279343-ybncwweg	150	8	glycans	glycan	NNS
cord-279343-ybncwweg	150	9	and	and	CC
cord-279343-ybncwweg	150	10	the	the	DT
cord-279343-ybncwweg	150	11	actual	actual	JJ
cord-279343-ybncwweg	150	12	shape	shape	NN
cord-279343-ybncwweg	150	13	of	of	IN
cord-279343-ybncwweg	150	14	the	the	DT
cord-279343-ybncwweg	150	15	protein	protein	NN
cord-279343-ybncwweg	150	16	presenting	present	VBG
cord-279343-ybncwweg	150	17	the	the	DT
cord-279343-ybncwweg	150	18	glycans	glycan	NNS
cord-279343-ybncwweg	150	19	influence	influence	VBP
cord-279343-ybncwweg	150	20	the	the	DT
cord-279343-ybncwweg	150	21	receptor	receptor	NN
cord-279343-ybncwweg	150	22	recognition	recognition	NN
cord-279343-ybncwweg	150	23	.	.	.
cord-279343-ybncwweg	151	1	For	for	IN
cord-279343-ybncwweg	151	2	example	example	NN
cord-279343-ybncwweg	151	3	,	,	,
cord-279343-ybncwweg	151	4	despite	despite	IN
cord-279343-ybncwweg	151	5	a	a	DT
cord-279343-ybncwweg	151	6	low	low	JJ
cord-279343-ybncwweg	151	7	score	score	NN
cord-279343-ybncwweg	151	8	for	for	IN
cord-279343-ybncwweg	151	9	Dengue	dengue	NN
cord-279343-ybncwweg	151	10	and	and	CC
cord-279343-ybncwweg	151	11	hemorrhagic	hemorrhagic	JJ
cord-279343-ybncwweg	151	12	fever	fever	NN
cord-279343-ybncwweg	151	13	,	,	,
cord-279343-ybncwweg	151	14	evidence	evidence	NN
cord-279343-ybncwweg	151	15	suggests	suggest	VBZ
cord-279343-ybncwweg	151	16	that	that	IN
cord-279343-ybncwweg	151	17	these	these	DT
cord-279343-ybncwweg	151	18	viruses	virus	NNS
cord-279343-ybncwweg	151	19	are	be	VBP
cord-279343-ybncwweg	151	20	recognized	recognize	VBN
cord-279343-ybncwweg	151	21	by	by	IN
cord-279343-ybncwweg	151	22	DC	DC	NNP
cord-279343-ybncwweg	151	23	-	-	HYPH
cord-279343-ybncwweg	151	24	SIGN	SIGN	NNP
cord-279343-ybncwweg	151	25	/	/	SYM
cord-279343-ybncwweg	151	26	R.	R.	NNP
cord-279343-ybncwweg	151	27	28	28	CD
cord-279343-ybncwweg	151	28	,	,	,
cord-279343-ybncwweg	151	29	29	29	CD
cord-279343-ybncwweg	152	1	Although	although	IN
cord-279343-ybncwweg	152	2	the	the	DT
cord-279343-ybncwweg	152	3	Dengue	Dengue	NNP
cord-279343-ybncwweg	152	4	virus	virus	NN
cord-279343-ybncwweg	152	5	envelope	envelope	NN
cord-279343-ybncwweg	152	6	protein	protein	NN
cord-279343-ybncwweg	152	7	is	be	VBZ
cord-279343-ybncwweg	152	8	not	not	RB
cord-279343-ybncwweg	152	9	heavily	heavily	RB
cord-279343-ybncwweg	152	10	glycosylated	glycosylate	VBN
cord-279343-ybncwweg	152	11	,	,	,
cord-279343-ybncwweg	153	1	the	the	DT
cord-279343-ybncwweg	153	2	crystal	crystal	NN
cord-279343-ybncwweg	153	3	structures	structure	NNS
cord-279343-ybncwweg	153	4	of	of	IN
cord-279343-ybncwweg	153	5	both	both	CC
cord-279343-ybncwweg	153	6	the	the	DT
cord-279343-ybncwweg	153	7	type	type	NN
cord-279343-ybncwweg	153	8	2	2	CD
cord-279343-ybncwweg	153	9	and	and	CC
cord-279343-ybncwweg	153	10	type	type	NN
cord-279343-ybncwweg	153	11	3	3	CD
cord-279343-ybncwweg	153	12	Dengue	dengue	NN
cord-279343-ybncwweg	153	13	envelope	envelope	NN
cord-279343-ybncwweg	153	14	protein	protein	NN
cord-279343-ybncwweg	153	15	E	e	NN
cord-279343-ybncwweg	153	16	showed	show	VBD
cord-279343-ybncwweg	153	17	that	that	IN
cord-279343-ybncwweg	153	18	the	the	DT
cord-279343-ybncwweg	153	19	two	two	CD
cord-279343-ybncwweg	153	20	conserved	conserved	JJ
cord-279343-ybncwweg	153	21	glycosylation	glycosylation	NN
cord-279343-ybncwweg	153	22	sites	site	NNS
cord-279343-ybncwweg	153	23	are	be	VBP
cord-279343-ybncwweg	153	24	located	locate	VBN
cord-279343-ybncwweg	153	25	at	at	IN
cord-279343-ybncwweg	153	26	the	the	DT
cord-279343-ybncwweg	153	27	protein	protein	NN
cord-279343-ybncwweg	153	28	dimer	dimer	NN
cord-279343-ybncwweg	153	29	interface	interface	NN
cord-279343-ybncwweg	153	30	,	,	,
cord-279343-ybncwweg	153	31	resulting	result	VBG
cord-279343-ybncwweg	153	32	in	in	IN
cord-279343-ybncwweg	153	33	four	four	CD
cord-279343-ybncwweg	153	34	glycans	glycan	NNS
cord-279343-ybncwweg	153	35	distributed	distribute	VBN
cord-279343-ybncwweg	153	36	symmetrically	symmetrically	RB
cord-279343-ybncwweg	153	37	at	at	IN
cord-279343-ybncwweg	153	38	w32	w32	NNP
cord-279343-ybncwweg	153	39	Å	å	NN
cord-279343-ybncwweg	153	40	apart	apart	RB
cord-279343-ybncwweg	153	41	across	across	IN
cord-279343-ybncwweg	153	42	the	the	DT
cord-279343-ybncwweg	153	43	interface	interface	NN
cord-279343-ybncwweg	153	44	.	.	.
cord-279343-ybncwweg	154	1	30	30	CD
cord-279343-ybncwweg	154	2	,	,	,
cord-279343-ybncwweg	154	3	31	31	CD
cord-279343-ybncwweg	154	4	This	this	DT
cord-279343-ybncwweg	154	5	generates	generate	VBZ
cord-279343-ybncwweg	154	6	four	four	CD
cord-279343-ybncwweg	154	7	closely	closely	RB
cord-279343-ybncwweg	154	8	packed	pack	VBN
cord-279343-ybncwweg	154	9	glycan	glycan	NN
cord-279343-ybncwweg	154	10	residues	residue	NNS
cord-279343-ybncwweg	154	11	,	,	,
cord-279343-ybncwweg	154	12	which	which	WDT
cord-279343-ybncwweg	154	13	enables	enable	VBZ
cord-279343-ybncwweg	154	14	the	the	DT
cord-279343-ybncwweg	154	15	recognition	recognition	NN
cord-279343-ybncwweg	154	16	by	by	IN
cord-279343-ybncwweg	154	17	the	the	DT
cord-279343-ybncwweg	154	18	tetrameric	tetrameric	JJ
cord-279343-ybncwweg	154	19	DC	DC	NNP
cord-279343-ybncwweg	154	20	-	-	HYPH
cord-279343-ybncwweg	154	21	SIGN	SIGN	NNP
cord-279343-ybncwweg	154	22	.	.	.
cord-279343-ybncwweg	155	1	This	this	DT
cord-279343-ybncwweg	155	2	equation	equation	NN
cord-279343-ybncwweg	155	3	is	be	VBZ
cord-279343-ybncwweg	155	4	thus	thus	RB
cord-279343-ybncwweg	155	5	a	a	DT
cord-279343-ybncwweg	155	6	first	first	JJ
cord-279343-ybncwweg	155	7	-	-	HYPH
cord-279343-ybncwweg	155	8	order	order	NN
cord-279343-ybncwweg	155	9	approximation	approximation	NN
cord-279343-ybncwweg	155	10	that	that	WDT
cord-279343-ybncwweg	155	11	does	do	VBZ
cord-279343-ybncwweg	155	12	not	not	RB
cord-279343-ybncwweg	155	13	reflect	reflect	VB
cord-279343-ybncwweg	155	14	variations	variation	NNS
cord-279343-ybncwweg	155	15	in	in	IN
cord-279343-ybncwweg	155	16	protein	protein	NN
cord-279343-ybncwweg	155	17	shape	shape	NN
cord-279343-ybncwweg	155	18	or	or	CC
cord-279343-ybncwweg	155	19	distribution	distribution	NN
cord-279343-ybncwweg	155	20	of	of	IN
cord-279343-ybncwweg	155	21	glycosylation	glycosylation	NN
cord-279343-ybncwweg	155	22	.	.	.
cord-279343-ybncwweg	156	1	In	in	IN
cord-279343-ybncwweg	156	2	conclusion	conclusion	NN
cord-279343-ybncwweg	156	3	,	,	,
cord-279343-ybncwweg	156	4	the	the	DT
cord-279343-ybncwweg	156	5	mechanism	mechanism	NN
cord-279343-ybncwweg	156	6	of	of	IN
cord-279343-ybncwweg	156	7	receptor	receptor	NN
cord-279343-ybncwweg	156	8	-	-	HYPH
cord-279343-ybncwweg	156	9	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	156	10	recognition	recognition	NN
cord-279343-ybncwweg	156	11	may	may	MD
cord-279343-ybncwweg	156	12	be	be	VB
cord-279343-ybncwweg	156	13	more	more	RBR
cord-279343-ybncwweg	156	14	complicated	complicated	JJ
cord-279343-ybncwweg	156	15	than	than	IN
cord-279343-ybncwweg	156	16	previously	previously	RB
cord-279343-ybncwweg	156	17	thought	think	VBN
cord-279343-ybncwweg	156	18	.	.	.
cord-279343-ybncwweg	157	1	The	the	DT
cord-279343-ybncwweg	157	2	high	high	JJ
cord-279343-ybncwweg	157	3	-	-	HYPH
cord-279343-ybncwweg	157	4	affinity	affinity	NN
cord-279343-ybncwweg	157	5	binding	binding	NN
cord-279343-ybncwweg	157	6	strategy	strategy	NN
cord-279343-ybncwweg	157	7	employed	employ	VBN
cord-279343-ybncwweg	157	8	by	by	IN
cord-279343-ybncwweg	157	9	these	these	DT
cord-279343-ybncwweg	157	10	receptors	receptor	NNS
cord-279343-ybncwweg	157	11	appears	appear	VBZ
cord-279343-ybncwweg	157	12	to	to	TO
cord-279343-ybncwweg	157	13	be	be	VB
cord-279343-ybncwweg	157	14	twofold	twofold	JJ
cord-279343-ybncwweg	157	15	.	.	.
cord-279343-ybncwweg	158	1	First	first	RB
cord-279343-ybncwweg	158	2	,	,	,
cord-279343-ybncwweg	158	3	the	the	DT
cord-279343-ybncwweg	158	4	structure	structure	NN
cord-279343-ybncwweg	158	5	of	of	IN
cord-279343-ybncwweg	158	6	each	each	DT
cord-279343-ybncwweg	158	7	individual	individual	JJ
cord-279343-ybncwweg	158	8	CRD	crd	NN
cord-279343-ybncwweg	158	9	determines	determine	VBZ
cord-279343-ybncwweg	158	10	the	the	DT
cord-279343-ybncwweg	158	11	preference	preference	NN
cord-279343-ybncwweg	158	12	of	of	IN
cord-279343-ybncwweg	158	13	the	the	DT
cord-279343-ybncwweg	158	14	receptor	receptor	NN
cord-279343-ybncwweg	158	15	for	for	IN
cord-279343-ybncwweg	158	16	particular	particular	JJ
cord-279343-ybncwweg	158	17	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	158	18	structures	structure	NNS
cord-279343-ybncwweg	158	19	.	.	.
cord-279343-ybncwweg	159	1	Secondly	secondly	RB
cord-279343-ybncwweg	159	2	,	,	,
cord-279343-ybncwweg	159	3	and	and	CC
cord-279343-ybncwweg	159	4	perhaps	perhaps	RB
cord-279343-ybncwweg	159	5	more	more	RBR
cord-279343-ybncwweg	159	6	importantly	importantly	RB
cord-279343-ybncwweg	159	7	,	,	,
cord-279343-ybncwweg	159	8	the	the	DT
cord-279343-ybncwweg	159	9	high	high	JJ
cord-279343-ybncwweg	159	10	-	-	HYPH
cord-279343-ybncwweg	159	11	affinity	affinity	NN
cord-279343-ybncwweg	159	12	interaction	interaction	NN
cord-279343-ybncwweg	159	13	as	as	RB
cord-279343-ybncwweg	159	14	well	well	RB
cord-279343-ybncwweg	159	15	as	as	IN
cord-279343-ybncwweg	159	16	ligand	ligand	NN
cord-279343-ybncwweg	159	17	specificity	specificity	NN
cord-279343-ybncwweg	159	18	rely	rely	VBP
cord-279343-ybncwweg	159	19	on	on	IN
cord-279343-ybncwweg	159	20	receptor	receptor	NN
cord-279343-ybncwweg	159	21	oligomerization	oligomerization	NN
cord-279343-ybncwweg	159	22	,	,	,
cord-279343-ybncwweg	159	23	which	which	WDT
cord-279343-ybncwweg	159	24	would	would	MD
cord-279343-ybncwweg	159	25	increase	increase	VB
cord-279343-ybncwweg	159	26	the	the	DT
cord-279343-ybncwweg	159	27	affinity	affinity	NN
cord-279343-ybncwweg	159	28	of	of	IN
cord-279343-ybncwweg	159	29	ligand	ligand	NN
cord-279343-ybncwweg	159	30	binding	binding	NN
cord-279343-ybncwweg	159	31	and	and	CC
cord-279343-ybncwweg	159	32	impose	impose	VB
cord-279343-ybncwweg	159	33	constraints	constraint	NNS
cord-279343-ybncwweg	159	34	on	on	IN
cord-279343-ybncwweg	159	35	the	the	DT
cord-279343-ybncwweg	159	36	density	density	NN
cord-279343-ybncwweg	159	37	and	and	CC
cord-279343-ybncwweg	159	38	distribution	distribution	NN
cord-279343-ybncwweg	159	39	of	of	IN
cord-279343-ybncwweg	159	40	carbohydrates	carbohydrate	NNS
cord-279343-ybncwweg	159	41	found	find	VBN
cord-279343-ybncwweg	159	42	on	on	IN
cord-279343-ybncwweg	159	43	target	target	NN
cord-279343-ybncwweg	159	44	pathogens	pathogen	NNS
cord-279343-ybncwweg	159	45	.	.	.
cord-279343-ybncwweg	160	1	Protein	protein	NN
cord-279343-ybncwweg	160	2	expression	expression	NN
cord-279343-ybncwweg	160	3	,	,	,
cord-279343-ybncwweg	160	4	purification	purification	NN
cord-279343-ybncwweg	160	5	and	and	CC
cord-279343-ybncwweg	160	6	crystallization	crystallization	NN
cord-279343-ybncwweg	160	7	DNA	dna	NN
cord-279343-ybncwweg	160	8	encoding	encoding	NN
cord-279343-ybncwweg	160	9	amino	amino	NN
cord-279343-ybncwweg	160	10	acid	acid	NN
cord-279343-ybncwweg	160	11	residues	residue	NNS
cord-279343-ybncwweg	160	12	250	250	CD
cord-279343-ybncwweg	160	13	-	-	SYM
cord-279343-ybncwweg	160	14	399	399	CD
cord-279343-ybncwweg	160	15	of	of	IN
cord-279343-ybncwweg	160	16	the	the	DT
cord-279343-ybncwweg	160	17	human	human	JJ
cord-279343-ybncwweg	160	18	DC	DC	NNP
cord-279343-ybncwweg	160	19	-	-	HYPH
cord-279343-ybncwweg	160	20	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	160	21	,	,	,
cord-279343-ybncwweg	160	22	which	which	WDT
cord-279343-ybncwweg	160	23	includes	include	VBZ
cord-279343-ybncwweg	160	24	the	the	DT
cord-279343-ybncwweg	160	25	last	last	JJ
cord-279343-ybncwweg	160	26	repeat	repeat	NN
cord-279343-ybncwweg	160	27	(	(	-LRB-
cord-279343-ybncwweg	160	28	R8	R8	NNP
cord-279343-ybncwweg	160	29	)	)	-RRB-
cord-279343-ybncwweg	160	30	and	and	CC
cord-279343-ybncwweg	160	31	the	the	DT
cord-279343-ybncwweg	160	32	CRD	crd	NN
cord-279343-ybncwweg	160	33	,	,	,
cord-279343-ybncwweg	160	34	referred	refer	VBD
cord-279343-ybncwweg	160	35	as	as	IN
cord-279343-ybncwweg	160	36	DC	DC	NNP
cord-279343-ybncwweg	160	37	-	-	HYPH
cord-279343-ybncwweg	160	38	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	160	39	R8	R8	NNP
cord-279343-ybncwweg	160	40	,	,	,
cord-279343-ybncwweg	160	41	was	be	VBD
cord-279343-ybncwweg	160	42	inserted	insert	VBN
cord-279343-ybncwweg	160	43	into	into	IN
cord-279343-ybncwweg	160	44	the	the	DT
cord-279343-ybncwweg	160	45	pET	pET	NNP
cord-279343-ybncwweg	160	46	22b	22b	CD
cord-279343-ybncwweg	160	47	vector	vector	NN
cord-279343-ybncwweg	160	48	(	(	-LRB-
cord-279343-ybncwweg	160	49	Figure	figure	NN
cord-279343-ybncwweg	160	50	1(a	1(a	CD
cord-279343-ybncwweg	160	51	)	)	-RRB-
cord-279343-ybncwweg	160	52	)	)	-RRB-
cord-279343-ybncwweg	160	53	.	.	.
cord-279343-ybncwweg	161	1	The	the	DT
cord-279343-ybncwweg	161	2	expression	expression	NN
cord-279343-ybncwweg	161	3	of	of	IN
cord-279343-ybncwweg	161	4	the	the	DT
cord-279343-ybncwweg	161	5	full	full	JJ
cord-279343-ybncwweg	161	6	-	-	HYPH
cord-279343-ybncwweg	161	7	length	length	NN
cord-279343-ybncwweg	161	8	extracellular	extracellular	JJ
cord-279343-ybncwweg	161	9	domain	domain	NN
cord-279343-ybncwweg	161	10	of	of	IN
cord-279343-ybncwweg	161	11	DC	DC	NNP
cord-279343-ybncwweg	161	12	-	-	HYPH
cord-279343-ybncwweg	161	13	SIGN	SIGN	NNP
cord-279343-ybncwweg	161	14	and	and	CC
cord-279343-ybncwweg	161	15	DC	DC	NNP
cord-279343-ybncwweg	161	16	-	-	HYPH
cord-279343-ybncwweg	161	17	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	161	18	has	have	VBZ
cord-279343-ybncwweg	161	19	been	be	VBN
cord-279343-ybncwweg	161	20	described	describe	VBN
cord-279343-ybncwweg	161	21	.	.	.
cord-279343-ybncwweg	162	1	21	21	CD
cord-279343-ybncwweg	162	2	Proteins	protein	NNS
cord-279343-ybncwweg	162	3	were	be	VBD
cord-279343-ybncwweg	162	4	expressed	express	VBN
cord-279343-ybncwweg	162	5	as	as	IN
cord-279343-ybncwweg	162	6	inclusion	inclusion	NN
cord-279343-ybncwweg	162	7	bodies	body	NNS
cord-279343-ybncwweg	162	8	in	in	IN
cord-279343-ybncwweg	162	9	Escherichia	Escherichia	NNP
cord-279343-ybncwweg	162	10	coli	coli	NNS
cord-279343-ybncwweg	163	1	BL21	BL21	NNP
cord-279343-ybncwweg	163	2	(	(	-LRB-
cord-279343-ybncwweg	163	3	DE3	DE3	NNP
cord-279343-ybncwweg	163	4	)	)	-RRB-
cord-279343-ybncwweg	163	5	and	and	CC
cord-279343-ybncwweg	163	6	reconstituted	reconstitute	VBN
cord-279343-ybncwweg	163	7	in	in	IN
cord-279343-ybncwweg	163	8	vitro	vitro	FW
cord-279343-ybncwweg	163	9	.	.	.
cord-279343-ybncwweg	164	1	Refolded	Refolded	NNP
cord-279343-ybncwweg	164	2	DC	DC	NNP
cord-279343-ybncwweg	164	3	-	-	HYPH
cord-279343-ybncwweg	164	4	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	164	5	R8	R8	NNP
cord-279343-ybncwweg	164	6	was	be	VBD
cord-279343-ybncwweg	164	7	loaded	load	VBN
cord-279343-ybncwweg	164	8	onto	onto	IN
cord-279343-ybncwweg	164	9	a	a	DT
cord-279343-ybncwweg	164	10	Source	source	NN
cord-279343-ybncwweg	164	11	15Q	15Q	NNP
cord-279343-ybncwweg	164	12	column	column	NN
cord-279343-ybncwweg	164	13	(	(	-LRB-
cord-279343-ybncwweg	164	14	Amersham	Amersham	NNP
cord-279343-ybncwweg	164	15	)	)	-RRB-
cord-279343-ybncwweg	164	16	and	and	CC
cord-279343-ybncwweg	164	17	further	further	RB
cord-279343-ybncwweg	164	18	purified	purify	VBN
cord-279343-ybncwweg	164	19	by	by	IN
cord-279343-ybncwweg	164	20	size	size	NN
cord-279343-ybncwweg	164	21	-	-	HYPH
cord-279343-ybncwweg	164	22	exclusion	exclusion	NN
cord-279343-ybncwweg	164	23	chromatography	chromatography	NN
cord-279343-ybncwweg	164	24	using	use	VBG
cord-279343-ybncwweg	164	25	a	a	DT
cord-279343-ybncwweg	164	26	Superdex	Superdex	NNP
cord-279343-ybncwweg	164	27	S200	S200	NNP
cord-279343-ybncwweg	164	28	column	column	NN
cord-279343-ybncwweg	164	29	(	(	-LRB-
cord-279343-ybncwweg	164	30	Amersham	Amersham	NNP
cord-279343-ybncwweg	164	31	)	)	-RRB-
cord-279343-ybncwweg	164	32	.	.	.
cord-279343-ybncwweg	165	1	The	the	DT
cord-279343-ybncwweg	165	2	peak	peak	NN
cord-279343-ybncwweg	165	3	fractions	fraction	NNS
cord-279343-ybncwweg	165	4	were	be	VBD
cord-279343-ybncwweg	165	5	then	then	RB
cord-279343-ybncwweg	165	6	concentrated	concentrate	VBN
cord-279343-ybncwweg	165	7	to	to	IN
cord-279343-ybncwweg	165	8	10	10	CD
cord-279343-ybncwweg	165	9	mg	mg	NNP
cord-279343-ybncwweg	165	10	/	/	SYM
cord-279343-ybncwweg	165	11	ml	ml	NN
cord-279343-ybncwweg	165	12	and	and	CC
cord-279343-ybncwweg	165	13	characterized	characterize	VBD
cord-279343-ybncwweg	165	14	using	use	VBG
cord-279343-ybncwweg	165	15	SDS	SDS	NNP
cord-279343-ybncwweg	165	16	-	-	HYPH
cord-279343-ybncwweg	165	17	PAGE	PAGE	NNP
cord-279343-ybncwweg	165	18	,	,	,
cord-279343-ybncwweg	165	19	N	n	CD
cord-279343-ybncwweg	165	20	-	-	HYPH
cord-279343-ybncwweg	165	21	terminal	terminal	NN
cord-279343-ybncwweg	165	22	sequencing	sequencing	NN
cord-279343-ybncwweg	165	23	and	and	CC
cord-279343-ybncwweg	165	24	mass	mass	NN
cord-279343-ybncwweg	165	25	spectrometry	spectrometry	NN
cord-279343-ybncwweg	165	26	.	.	.
cord-279343-ybncwweg	166	1	Initial	initial	JJ
cord-279343-ybncwweg	166	2	crystallization	crystallization	NN
cord-279343-ybncwweg	166	3	screening	screening	NN
cord-279343-ybncwweg	166	4	trials	trial	NNS
cord-279343-ybncwweg	166	5	were	be	VBD
cord-279343-ybncwweg	166	6	carried	carry	VBN
cord-279343-ybncwweg	166	7	out	out	RP
cord-279343-ybncwweg	166	8	by	by	IN
cord-279343-ybncwweg	166	9	microbatch	microbatch	NN
cord-279343-ybncwweg	166	10	experiments	experiment	NNS
cord-279343-ybncwweg	166	11	using	use	VBG
cord-279343-ybncwweg	166	12	an	an	DT
cord-279343-ybncwweg	166	13	automated	automate	VBN
cord-279343-ybncwweg	166	14	crystallization	crystallization	NN
cord-279343-ybncwweg	166	15	robot	robot	NN
cord-279343-ybncwweg	166	16	(	(	-LRB-
cord-279343-ybncwweg	166	17	Douglas	Douglas	NNP
cord-279343-ybncwweg	166	18	Instruments	Instruments	NNP
cord-279343-ybncwweg	166	19	Oryx	Oryx	NNP
cord-279343-ybncwweg	166	20	6	6	CD
cord-279343-ybncwweg	166	21	)	)	-RRB-
cord-279343-ybncwweg	166	22	.	.	.
cord-279343-ybncwweg	167	1	32	32	CD
cord-279343-ybncwweg	167	2	,	,	,
cord-279343-ybncwweg	167	3	33	33	CD
cord-279343-ybncwweg	167	4	Repeated	repeat	VBN
cord-279343-ybncwweg	167	5	attempts	attempt	NNS
cord-279343-ybncwweg	167	6	to	to	TO
cord-279343-ybncwweg	167	7	crystallize	crystallize	VB
cord-279343-ybncwweg	167	8	the	the	DT
cord-279343-ybncwweg	167	9	entire	entire	JJ
cord-279343-ybncwweg	167	10	ectodomain	ectodomain	NN
cord-279343-ybncwweg	167	11	of	of	IN
cord-279343-ybncwweg	167	12	either	either	DT
cord-279343-ybncwweg	167	13	DC	DC	NNP
cord-279343-ybncwweg	167	14	-	-	HYPH
cord-279343-ybncwweg	167	15	SIGN	SIGN	NNP
cord-279343-ybncwweg	167	16	or	or	CC
cord-279343-ybncwweg	167	17	DC	DC	NNP
cord-279343-ybncwweg	167	18	-	-	HYPH
cord-279343-ybncwweg	167	19	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	167	20	did	do	VBD
cord-279343-ybncwweg	167	21	not	not	RB
cord-279343-ybncwweg	167	22	yield	yield	VB
cord-279343-ybncwweg	167	23	any	any	DT
cord-279343-ybncwweg	167	24	diffraction	diffraction	NN
cord-279343-ybncwweg	167	25	-	-	HYPH
cord-279343-ybncwweg	167	26	quality	quality	NN
cord-279343-ybncwweg	167	27	crystals	crystal	NNS
cord-279343-ybncwweg	167	28	.	.	.
cord-279343-ybncwweg	168	1	In	in	IN
cord-279343-ybncwweg	168	2	contrast	contrast	NN
cord-279343-ybncwweg	168	3	,	,	,
cord-279343-ybncwweg	168	4	rod	rod	NN
cord-279343-ybncwweg	168	5	-	-	HYPH
cord-279343-ybncwweg	168	6	like	like	JJ
cord-279343-ybncwweg	168	7	crystals	crystal	NNS
cord-279343-ybncwweg	168	8	of	of	IN
cord-279343-ybncwweg	168	9	the	the	DT
cord-279343-ybncwweg	168	10	DC	DC	NNP
cord-279343-ybncwweg	168	11	-	-	HYPH
cord-279343-ybncwweg	168	12	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	168	13	R8	r8	NN
cord-279343-ybncwweg	168	14	construct	construct	NN
cord-279343-ybncwweg	168	15	appeared	appear	VBN
cord-279343-ybncwweg	168	16	in	in	IN
cord-279343-ybncwweg	168	17	many	many	JJ
cord-279343-ybncwweg	168	18	conditions	condition	NNS
cord-279343-ybncwweg	168	19	within	within	IN
cord-279343-ybncwweg	168	20	six	six	CD
cord-279343-ybncwweg	168	21	hours	hour	NNS
cord-279343-ybncwweg	168	22	of	of	IN
cord-279343-ybncwweg	168	23	setup	setup	NN
cord-279343-ybncwweg	168	24	.	.	.
cord-279343-ybncwweg	169	1	Optimization	optimization	NN
cord-279343-ybncwweg	169	2	of	of	IN
cord-279343-ybncwweg	169	3	crystal	crystal	NN
cord-279343-ybncwweg	169	4	growth	growth	NN
cord-279343-ybncwweg	169	5	conditions	condition	NNS
cord-279343-ybncwweg	169	6	was	be	VBD
cord-279343-ybncwweg	169	7	performed	perform	VBN
cord-279343-ybncwweg	169	8	by	by	IN
cord-279343-ybncwweg	169	9	fine	fine	JJ
cord-279343-ybncwweg	169	10	-	-	HYPH
cord-279343-ybncwweg	169	11	screening	screening	NN
cord-279343-ybncwweg	169	12	of	of	IN
cord-279343-ybncwweg	169	13	pH	ph	NN
cord-279343-ybncwweg	169	14	and	and	CC
cord-279343-ybncwweg	169	15	precipitant	precipitant	JJ
cord-279343-ybncwweg	169	16	concentration	concentration	NN
cord-279343-ybncwweg	169	17	.	.	.
cord-279343-ybncwweg	170	1	Crystals	crystal	NNS
cord-279343-ybncwweg	170	2	used	use	VBD
cord-279343-ybncwweg	170	3	for	for	IN
cord-279343-ybncwweg	170	4	X	x	NN
cord-279343-ybncwweg	170	5	-	-	NN
cord-279343-ybncwweg	170	6	ray	ray	NN
cord-279343-ybncwweg	170	7	data	datum	NNS
cord-279343-ybncwweg	170	8	collection	collection	NN
cord-279343-ybncwweg	170	9	were	be	VBD
cord-279343-ybncwweg	170	10	grown	grow	VBN
cord-279343-ybncwweg	170	11	by	by	IN
cord-279343-ybncwweg	170	12	the	the	DT
cord-279343-ybncwweg	170	13	hanging	hanging	NN
cord-279343-ybncwweg	170	14	-	-	HYPH
cord-279343-ybncwweg	170	15	drop	drop	NN
cord-279343-ybncwweg	170	16	,	,	,
cord-279343-ybncwweg	170	17	vapordiffusion	vapordiffusion	NN
cord-279343-ybncwweg	170	18	method	method	NN
cord-279343-ybncwweg	170	19	in	in	IN
cord-279343-ybncwweg	170	20	a	a	DT
cord-279343-ybncwweg	170	21	well	well	JJ
cord-279343-ybncwweg	170	22	solution	solution	NN
cord-279343-ybncwweg	170	23	of	of	IN
cord-279343-ybncwweg	170	24	100	100	CD
cord-279343-ybncwweg	170	25	mM	mm	CD
cord-279343-ybncwweg	170	26	MgCl	MgCl	NNP
cord-279343-ybncwweg	170	27	2	2	CD
cord-279343-ybncwweg	170	28	,	,	,
cord-279343-ybncwweg	170	29	100	100	CD
cord-279343-ybncwweg	170	30	mM	mm	CD
cord-279343-ybncwweg	170	31	sodium	sodium	NN
cord-279343-ybncwweg	170	32	cacodylate	cacodylate	NN
cord-279343-ybncwweg	170	33	(	(	-LRB-
cord-279343-ybncwweg	170	34	pH	pH	NNP
cord-279343-ybncwweg	170	35	6.5	6.5	CD
cord-279343-ybncwweg	170	36	)	)	-RRB-
cord-279343-ybncwweg	170	37	,	,	,
cord-279343-ybncwweg	170	38	12	12	CD
cord-279343-ybncwweg	170	39	%	%	NN
cord-279343-ybncwweg	170	40	(	(	-LRB-
cord-279343-ybncwweg	170	41	w	w	NN
cord-279343-ybncwweg	170	42	/	/	SYM
cord-279343-ybncwweg	170	43	v	v	NN
cord-279343-ybncwweg	170	44	)	)	-RRB-
cord-279343-ybncwweg	170	45	polyethylene	polyethylene	NN
cord-279343-ybncwweg	170	46	glycol	glycol	NN
cord-279343-ybncwweg	170	47	3000	3000	CD
cord-279343-ybncwweg	170	48	.	.	.
cord-279343-ybncwweg	171	1	Crystals	crystal	NNS
cord-279343-ybncwweg	171	2	of	of	IN
cord-279343-ybncwweg	171	3	DC	DC	NNP
cord-279343-ybncwweg	171	4	-	-	HYPH
cord-279343-ybncwweg	171	5	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	171	6	R8	R8	NNP
cord-279343-ybncwweg	171	7	were	be	VBD
cord-279343-ybncwweg	171	8	briefly	briefly	RB
cord-279343-ybncwweg	171	9	transferred	transfer	VBN
cord-279343-ybncwweg	171	10	into	into	IN
cord-279343-ybncwweg	171	11	well	well	JJ
cord-279343-ybncwweg	171	12	solution	solution	NN
cord-279343-ybncwweg	171	13	supplemented	supplement	VBN
cord-279343-ybncwweg	171	14	with	with	IN
cord-279343-ybncwweg	171	15	20	20	CD
cord-279343-ybncwweg	171	16	%	%	NN
cord-279343-ybncwweg	171	17	(	(	-LRB-
cord-279343-ybncwweg	171	18	v	v	NN
cord-279343-ybncwweg	171	19	/	/	SYM
cord-279343-ybncwweg	171	20	v	v	NN
cord-279343-ybncwweg	171	21	)	)	-RRB-
cord-279343-ybncwweg	171	22	glycerol	glycerol	NN
cord-279343-ybncwweg	171	23	and	and	CC
cord-279343-ybncwweg	171	24	flash	flash	NN
cord-279343-ybncwweg	171	25	-	-	HYPH
cord-279343-ybncwweg	171	26	frozen	freeze	VBN
cord-279343-ybncwweg	171	27	in	in	IN
cord-279343-ybncwweg	171	28	a	a	DT
cord-279343-ybncwweg	171	29	liquid	liquid	JJ
cord-279343-ybncwweg	171	30	nitrogen	nitrogen	NN
cord-279343-ybncwweg	171	31	stream	stream	NN
cord-279343-ybncwweg	171	32	at	at	IN
cord-279343-ybncwweg	171	33	100	100	CD
cord-279343-ybncwweg	171	34	K.	K.	NNP
cord-279343-ybncwweg	172	1	The	the	DT
cord-279343-ybncwweg	172	2	X	x	NN
cord-279343-ybncwweg	172	3	-	-	NN
cord-279343-ybncwweg	172	4	ray	ray	NN
cord-279343-ybncwweg	172	5	diffraction	diffraction	NN
cord-279343-ybncwweg	172	6	data	datum	NNS
cord-279343-ybncwweg	172	7	were	be	VBD
cord-279343-ybncwweg	172	8	collected	collect	VBN
cord-279343-ybncwweg	172	9	on	on	IN
cord-279343-ybncwweg	172	10	a	a	DT
cord-279343-ybncwweg	172	11	3X3	3x3	CD
cord-279343-ybncwweg	172	12	chargecoupled	chargecoupled	JJ
cord-279343-ybncwweg	172	13	device	device	NN
cord-279343-ybncwweg	172	14	detector	detector	NN
cord-279343-ybncwweg	172	15	at	at	IN
cord-279343-ybncwweg	172	16	the	the	DT
cord-279343-ybncwweg	172	17	Structural	Structural	NNP
cord-279343-ybncwweg	172	18	Biology	Biology	NNP
cord-279343-ybncwweg	172	19	Center	Center	NNP
cord-279343-ybncwweg	172	20	Collaborative	Collaborative	NNP
cord-279343-ybncwweg	172	21	Access	Access	NNP
cord-279343-ybncwweg	172	22	Team	Team	NNP
cord-279343-ybncwweg	172	23	beamline	beamline	NN
cord-279343-ybncwweg	172	24	19ID	19id	CD
cord-279343-ybncwweg	172	25	and	and	CC
cord-279343-ybncwweg	172	26	processed	process	VBN
cord-279343-ybncwweg	172	27	using	use	VBG
cord-279343-ybncwweg	172	28	HKL2000	HKL2000	NNP
cord-279343-ybncwweg	172	29	.	.	.
cord-279343-ybncwweg	173	1	34	34	CD
cord-279343-ybncwweg	174	1	The	the	DT
cord-279343-ybncwweg	174	2	crystals	crystal	NNS
cord-279343-ybncwweg	174	3	diffracted	diffract	VBN
cord-279343-ybncwweg	174	4	to	to	IN
cord-279343-ybncwweg	174	5	1.41	1.41	CD
cord-279343-ybncwweg	174	6	Å	å	NN
cord-279343-ybncwweg	174	7	and	and	CC
cord-279343-ybncwweg	174	8	were	be	VBD
cord-279343-ybncwweg	174	9	indexed	index	VBN
cord-279343-ybncwweg	174	10	to	to	IN
cord-279343-ybncwweg	174	11	the	the	DT
cord-279343-ybncwweg	174	12	orthorhombic	orthorhombic	JJ
cord-279343-ybncwweg	174	13	space	space	NN
cord-279343-ybncwweg	174	14	group	group	NN
cord-279343-ybncwweg	174	15	P2	P2	NNP
cord-279343-ybncwweg	174	16	1	1	CD
cord-279343-ybncwweg	174	17	2	2	CD
cord-279343-ybncwweg	174	18	1	1	CD
cord-279343-ybncwweg	174	19	2	2	CD
cord-279343-ybncwweg	174	20	1	1	CD
cord-279343-ybncwweg	174	21	with	with	IN
cord-279343-ybncwweg	174	22	cell	cell	NN
cord-279343-ybncwweg	174	23	dimensions	dimension	NNS
cord-279343-ybncwweg	174	24	aZ38.2	az38.2	IN
cord-279343-ybncwweg	174	25	Å	å	NN
cord-279343-ybncwweg	174	26	,	,	,
cord-279343-ybncwweg	174	27	bZ54.8	bZ54.8	NNP
cord-279343-ybncwweg	174	28	Å	å	NN
cord-279343-ybncwweg	174	29	,	,	,
cord-279343-ybncwweg	174	30	and	and	CC
cord-279343-ybncwweg	174	31	cZ62.3	cZ62.3	NNP
cord-279343-ybncwweg	174	32	Å	Å	NNP
cord-279343-ybncwweg	174	33	.	.	.
cord-279343-ybncwweg	175	1	Molecular	molecular	JJ
cord-279343-ybncwweg	175	2	replacement	replacement	NN
cord-279343-ybncwweg	175	3	using	use	VBG
cord-279343-ybncwweg	175	4	the	the	DT
cord-279343-ybncwweg	175	5	coordinates	coordinate	NNS
cord-279343-ybncwweg	175	6	for	for	IN
cord-279343-ybncwweg	175	7	DC	DC	NNP
cord-279343-ybncwweg	175	8	-	-	HYPH
cord-279343-ybncwweg	175	9	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	175	10	CRD	crd	NN
cord-279343-ybncwweg	176	1	(	(	-LRB-
cord-279343-ybncwweg	176	2	PDB	PDB	NNP
cord-279343-ybncwweg	176	3	accession	accession	NN
cord-279343-ybncwweg	176	4	code	code	NN
cord-279343-ybncwweg	176	5	1K9J	1k9j	CD
cord-279343-ybncwweg	176	6	)	)	-RRB-
cord-279343-ybncwweg	176	7	provided	provide	VBD
cord-279343-ybncwweg	176	8	phase	phase	NN
cord-279343-ybncwweg	176	9	information	information	NN
cord-279343-ybncwweg	176	10	.	.	.
cord-279343-ybncwweg	177	1	18	18	CD
cord-279343-ybncwweg	177	2	Diffraction	diffraction	NN
cord-279343-ybncwweg	177	3	data	datum	NNS
cord-279343-ybncwweg	177	4	from	from	IN
cord-279343-ybncwweg	177	5	41	41	CD
cord-279343-ybncwweg	177	6	-	-	SYM
cord-279343-ybncwweg	177	7	3.0	3.0	CD
cord-279343-ybncwweg	177	8	Å	å	NN
cord-279343-ybncwweg	177	9	were	be	VBD
cord-279343-ybncwweg	177	10	used	use	VBN
cord-279343-ybncwweg	177	11	for	for	IN
cord-279343-ybncwweg	177	12	the	the	DT
cord-279343-ybncwweg	177	13	rotation	rotation	NN
cord-279343-ybncwweg	177	14	and	and	CC
cord-279343-ybncwweg	177	15	translation	translation	NN
cord-279343-ybncwweg	177	16	functions	function	NNS
cord-279343-ybncwweg	177	17	with	with	IN
cord-279343-ybncwweg	177	18	the	the	DT
cord-279343-ybncwweg	177	19	program	program	NN
cord-279343-ybncwweg	177	20	AMoRe	amore	NN
cord-279343-ybncwweg	177	21	.	.	.
cord-279343-ybncwweg	177	22	35	35	CD
cord-279343-ybncwweg	177	23	After	after	IN
cord-279343-ybncwweg	177	24	rigid	rigid	JJ
cord-279343-ybncwweg	177	25	body	body	NN
cord-279343-ybncwweg	177	26	refinement	refinement	NN
cord-279343-ybncwweg	177	27	using	use	VBG
cord-279343-ybncwweg	177	28	program	program	NN
cord-279343-ybncwweg	177	29	packages	package	NNS
cord-279343-ybncwweg	177	30	AMoRe	AMoRe	NNP
cord-279343-ybncwweg	177	31	and	and	CC
cord-279343-ybncwweg	177	32	CNS	CNS	NNP
cord-279343-ybncwweg	177	33	.	.	.
cord-279343-ybncwweg	178	1	36	36	CD
cord-279343-ybncwweg	179	1	A	a	DT
cord-279343-ybncwweg	179	2	complete	complete	JJ
cord-279343-ybncwweg	179	3	model	model	NN
cord-279343-ybncwweg	179	4	was	be	VBD
cord-279343-ybncwweg	179	5	built	build	VBN
cord-279343-ybncwweg	179	6	with	with	IN
cord-279343-ybncwweg	179	7	the	the	DT
cord-279343-ybncwweg	179	8	occupancies	occupancy	NNS
cord-279343-ybncwweg	179	9	for	for	IN
cord-279343-ybncwweg	179	10	disordered	disordered	JJ
cord-279343-ybncwweg	179	11	side	side	NN
cord-279343-ybncwweg	179	12	-	-	HYPH
cord-279343-ybncwweg	179	13	chains	chain	NNS
cord-279343-ybncwweg	179	14	and	and	CC
cord-279343-ybncwweg	179	15	loops	loop	NNS
cord-279343-ybncwweg	179	16	set	set	VBN
cord-279343-ybncwweg	179	17	to	to	IN
cord-279343-ybncwweg	179	18	zero	zero	CD
cord-279343-ybncwweg	179	19	.	.	.
cord-279343-ybncwweg	180	1	Initial	initial	JJ
cord-279343-ybncwweg	180	2	refinement	refinement	NN
cord-279343-ybncwweg	180	3	in	in	IN
cord-279343-ybncwweg	180	4	CNS	CNS	NNP
cord-279343-ybncwweg	180	5	included	include	VBD
cord-279343-ybncwweg	180	6	simulated	simulated	JJ
cord-279343-ybncwweg	180	7	annealing	annealing	NN
cord-279343-ybncwweg	180	8	,	,	,
cord-279343-ybncwweg	180	9	conjugate	conjugate	JJ
cord-279343-ybncwweg	180	10	gradient	gradient	NN
cord-279343-ybncwweg	180	11	minimization	minimization	NN
cord-279343-ybncwweg	180	12	and	and	CC
cord-279343-ybncwweg	180	13	individual	individual	JJ
cord-279343-ybncwweg	180	14	temperature	temperature	NN
cord-279343-ybncwweg	180	15	factor	factor	NN
cord-279343-ybncwweg	180	16	refinement	refinement	NN
cord-279343-ybncwweg	180	17	.	.	.
cord-279343-ybncwweg	181	1	Further	further	JJ
cord-279343-ybncwweg	181	2	refinement	refinement	NN
cord-279343-ybncwweg	181	3	using	use	VBG
cord-279343-ybncwweg	181	4	maximum	maximum	JJ
cord-279343-ybncwweg	181	5	likelihood	likelihood	NN
cord-279343-ybncwweg	181	6	methods	method	NNS
cord-279343-ybncwweg	181	7	was	be	VBD
cord-279343-ybncwweg	181	8	performed	perform	VBN
cord-279343-ybncwweg	181	9	with	with	IN
cord-279343-ybncwweg	181	10	the	the	DT
cord-279343-ybncwweg	181	11	program	program	NN
cord-279343-ybncwweg	181	12	Refmac	Refmac	NNP
cord-279343-ybncwweg	181	13	5	5	CD
cord-279343-ybncwweg	181	14	.	.	.
cord-279343-ybncwweg	182	1	35	35	CD
cord-279343-ybncwweg	183	1	The	the	DT
cord-279343-ybncwweg	183	2	final	final	JJ
cord-279343-ybncwweg	183	3	geometry	geometry	NN
cord-279343-ybncwweg	183	4	of	of	IN
cord-279343-ybncwweg	183	5	the	the	DT
cord-279343-ybncwweg	183	6	structure	structure	NN
cord-279343-ybncwweg	183	7	was	be	VBD
cord-279343-ybncwweg	183	8	evaluated	evaluate	VBN
cord-279343-ybncwweg	183	9	using	use	VBG
cord-279343-ybncwweg	183	10	the	the	DT
cord-279343-ybncwweg	183	11	program	program	NN
cord-279343-ybncwweg	183	12	PROCHECK	PROCHECK	NNP
cord-279343-ybncwweg	183	13	.	.	.
cord-279343-ybncwweg	184	1	37	37	CD
cord-279343-ybncwweg	184	2	Least	Least	JJS
cord-279343-ybncwweg	184	3	-	-	HYPH
cord-279343-ybncwweg	184	4	squares	square	NNS
cord-279343-ybncwweg	184	5	superpositions	superposition	NNS
cord-279343-ybncwweg	184	6	were	be	VBD
cord-279343-ybncwweg	184	7	performed	perform	VBN
cord-279343-ybncwweg	184	8	using	use	VBG
cord-279343-ybncwweg	184	9	the	the	DT
cord-279343-ybncwweg	184	10	program	program	NN
cord-279343-ybncwweg	184	11	LSQMAN	LSQMAN	NNP
cord-279343-ybncwweg	184	12	.	.	.
cord-279343-ybncwweg	185	1	38	38	CD
cord-279343-ybncwweg	185	2	Modeling	modeling	NN
cord-279343-ybncwweg	185	3	of	of	IN
cord-279343-ybncwweg	185	4	the	the	DT
cord-279343-ybncwweg	185	5	DC	DC	NNP
cord-279343-ybncwweg	185	6	-	-	HYPH
cord-279343-ybncwweg	185	7	SIGN	SIGN	NNP
cord-279343-ybncwweg	185	8	tetramer	tetramer	NN
cord-279343-ybncwweg	185	9	A	a	DT
cord-279343-ybncwweg	185	10	protein	protein	NN
cord-279343-ybncwweg	185	11	search	search	NN
cord-279343-ybncwweg	185	12	using	use	VBG
cord-279343-ybncwweg	185	13	the	the	DT
cord-279343-ybncwweg	185	14	program	program	NN
cord-279343-ybncwweg	185	15	BLASTp	BLASTp	NNS
cord-279343-ybncwweg	185	16	for	for	IN
cord-279343-ybncwweg	185	17	sequences	sequence	NNS
cord-279343-ybncwweg	185	18	corresponding	correspond	VBG
cord-279343-ybncwweg	185	19	to	to	IN
cord-279343-ybncwweg	185	20	one	one	CD
cord-279343-ybncwweg	185	21	,	,	,
cord-279343-ybncwweg	185	22	two	two	CD
cord-279343-ybncwweg	185	23	,	,	,
cord-279343-ybncwweg	185	24	three	three	CD
cord-279343-ybncwweg	185	25	,	,	,
cord-279343-ybncwweg	185	26	four	four	CD
cord-279343-ybncwweg	185	27	and	and	CC
cord-279343-ybncwweg	185	28	all	all	DT
cord-279343-ybncwweg	185	29	eight	eight	CD
cord-279343-ybncwweg	185	30	repeat	repeat	NN
cord-279343-ybncwweg	185	31	domains	domain	NNS
cord-279343-ybncwweg	185	32	of	of	IN
cord-279343-ybncwweg	185	33	DC	DC	NNP
cord-279343-ybncwweg	185	34	-	-	HYPH
cord-279343-ybncwweg	185	35	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	185	36	in	in	IN
cord-279343-ybncwweg	185	37	various	various	JJ
cord-279343-ybncwweg	185	38	combinations	combination	NNS
cord-279343-ybncwweg	185	39	was	be	VBD
cord-279343-ybncwweg	185	40	used	use	VBN
cord-279343-ybncwweg	185	41	to	to	TO
cord-279343-ybncwweg	185	42	query	query	VB
cord-279343-ybncwweg	185	43	the	the	DT
cord-279343-ybncwweg	185	44	PDB	PDB	NNP
cord-279343-ybncwweg	185	45	.	.	.
cord-279343-ybncwweg	186	1	39	39	CD
cord-279343-ybncwweg	187	1	From	from	IN
cord-279343-ybncwweg	187	2	this	this	DT
cord-279343-ybncwweg	187	3	search	search	NN
cord-279343-ybncwweg	187	4	we	-PRON-	PRP
cord-279343-ybncwweg	187	5	identified	identify	VBD
cord-279343-ybncwweg	187	6	a	a	DT
cord-279343-ybncwweg	187	7	representative	representative	JJ
cord-279343-ybncwweg	187	8	set	set	NN
cord-279343-ybncwweg	187	9	of	of	IN
cord-279343-ybncwweg	187	10	structures	structure	NNS
cord-279343-ybncwweg	187	11	that	that	WDT
cord-279343-ybncwweg	187	12	includes	include	VBZ
cord-279343-ybncwweg	187	13	focal	focal	JJ
cord-279343-ybncwweg	187	14	adhesion	adhesion	NN
cord-279343-ybncwweg	187	15	kinases	kinase	NNS
cord-279343-ybncwweg	187	16	,	,	,
cord-279343-ybncwweg	187	17	Taq	Taq	NNP
cord-279343-ybncwweg	187	18	Muts	Muts	NNP
cord-279343-ybncwweg	187	19	and	and	CC
cord-279343-ybncwweg	187	20	DNA	dna	NN
cord-279343-ybncwweg	187	21	-	-	HYPH
cord-279343-ybncwweg	187	22	binding	bind	VBG
cord-279343-ybncwweg	187	23	proteins	protein	NNS
cord-279343-ybncwweg	187	24	,	,	,
cord-279343-ybncwweg	187	25	with	with	IN
cord-279343-ybncwweg	187	26	sequence	sequence	NN
cord-279343-ybncwweg	187	27	identity	identity	NN
cord-279343-ybncwweg	187	28	of	of	IN
cord-279343-ybncwweg	187	29	30	30	CD
cord-279343-ybncwweg	187	30	-	-	SYM
cord-279343-ybncwweg	187	31	70	70	CD
cord-279343-ybncwweg	187	32	%	%	NN
cord-279343-ybncwweg	187	33	(	(	-LRB-
cord-279343-ybncwweg	187	34	PDB	PDB	NNP
cord-279343-ybncwweg	187	35	accession	accession	NN
cord-279343-ybncwweg	187	36	codes	code	VBZ
cord-279343-ybncwweg	187	37	1K05	1k05	CD
cord-279343-ybncwweg	187	38	,	,	,
cord-279343-ybncwweg	187	39	1P85	1p85	CD
cord-279343-ybncwweg	187	40	,	,	,
cord-279343-ybncwweg	187	41	1IOM	1iom	CD
cord-279343-ybncwweg	187	42	,	,	,
cord-279343-ybncwweg	187	43	1NNE	1nne	CD
cord-279343-ybncwweg	187	44	,	,	,
cord-279343-ybncwweg	187	45	1NKW	1nkw	CD
cord-279343-ybncwweg	187	46	,	,	,
cord-279343-ybncwweg	187	47	1EWR	1ewr	CD
cord-279343-ybncwweg	187	48	,	,	,
cord-279343-ybncwweg	187	49	1ITW	1itw	CD
cord-279343-ybncwweg	187	50	and	and	CC
cord-279343-ybncwweg	187	51	1HP7	1hp7	CD
cord-279343-ybncwweg	187	52	)	)	-RRB-
cord-279343-ybncwweg	187	53	.	.	.
cord-279343-ybncwweg	188	1	The	the	DT
cord-279343-ybncwweg	188	2	homologous	homologous	JJ
cord-279343-ybncwweg	188	3	portions	portion	NNS
cord-279343-ybncwweg	188	4	of	of	IN
cord-279343-ybncwweg	188	5	these	these	DT
cord-279343-ybncwweg	188	6	structures	structure	NNS
cord-279343-ybncwweg	188	7	were	be	VBD
cord-279343-ybncwweg	188	8	aligned	align	VBN
cord-279343-ybncwweg	188	9	on	on	IN
cord-279343-ybncwweg	188	10	the	the	DT
cord-279343-ybncwweg	188	11	basis	basis	NN
cord-279343-ybncwweg	188	12	of	of	IN
cord-279343-ybncwweg	188	13	sequence	sequence	NN
cord-279343-ybncwweg	188	14	homology	homology	NN
cord-279343-ybncwweg	188	15	to	to	IN
cord-279343-ybncwweg	188	16	each	each	DT
cord-279343-ybncwweg	188	17	corresponding	corresponding	JJ
cord-279343-ybncwweg	188	18	repeat	repeat	NN
cord-279343-ybncwweg	188	19	subunit	subunit	NN
cord-279343-ybncwweg	188	20	of	of	IN
cord-279343-ybncwweg	188	21	DC	DC	NNP
cord-279343-ybncwweg	188	22	-	-	HYPH
cord-279343-ybncwweg	188	23	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	188	24	,	,	,
cord-279343-ybncwweg	188	25	and	and	CC
cord-279343-ybncwweg	188	26	their	-PRON-	PRP$
cord-279343-ybncwweg	188	27	secondary	secondary	JJ
cord-279343-ybncwweg	188	28	structure	structure	NN
cord-279343-ybncwweg	188	29	was	be	VBD
cord-279343-ybncwweg	188	30	viewed	view	VBN
cord-279343-ybncwweg	188	31	using	use	VBG
cord-279343-ybncwweg	188	32	the	the	DT
cord-279343-ybncwweg	188	33	program	program	NN
cord-279343-ybncwweg	188	34	O.	O.	NNP
cord-279343-ybncwweg	188	35	40	40	CD
cord-279343-ybncwweg	189	1	The	the	DT
cord-279343-ybncwweg	189	2	structure	structure	NN
cord-279343-ybncwweg	189	3	of	of	IN
cord-279343-ybncwweg	189	4	the	the	DT
cord-279343-ybncwweg	189	5	focal	focal	JJ
cord-279343-ybncwweg	189	6	adhesion	adhesion	NN
cord-279343-ybncwweg	189	7	kinase	kinase	NN
cord-279343-ybncwweg	189	8	(	(	-LRB-
cord-279343-ybncwweg	189	9	PDB	PDB	NNP
cord-279343-ybncwweg	189	10	code	code	NN
cord-279343-ybncwweg	189	11	1K05	1k05	CD
cord-279343-ybncwweg	189	12	)	)	-RRB-
cord-279343-ybncwweg	189	13	was	be	VBD
cord-279343-ybncwweg	189	14	used	use	VBN
cord-279343-ybncwweg	189	15	as	as	IN
cord-279343-ybncwweg	189	16	a	a	DT
cord-279343-ybncwweg	189	17	template	template	NN
cord-279343-ybncwweg	189	18	for	for	IN
cord-279343-ybncwweg	189	19	tetramer	tetramer	NN
cord-279343-ybncwweg	189	20	formation	formation	NN
cord-279343-ybncwweg	189	21	,	,	,
cord-279343-ybncwweg	189	22	with	with	IN
cord-279343-ybncwweg	189	23	the	the	DT
cord-279343-ybncwweg	189	24	additional	additional	JJ
cord-279343-ybncwweg	189	25	structures	structure	NNS
cord-279343-ybncwweg	189	26	being	be	VBG
cord-279343-ybncwweg	189	27	used	use	VBN
cord-279343-ybncwweg	189	28	primarily	primarily	RB
cord-279343-ybncwweg	189	29	to	to	TO
cord-279343-ybncwweg	189	30	predict	predict	VB
cord-279343-ybncwweg	189	31	location	location	NN
cord-279343-ybncwweg	189	32	of	of	IN
cord-279343-ybncwweg	189	33	turns	turn	NNS
cord-279343-ybncwweg	189	34	.	.	.
cord-279343-ybncwweg	190	1	The	the	DT
cord-279343-ybncwweg	190	2	final	final	JJ
cord-279343-ybncwweg	190	3	model	model	NN
cord-279343-ybncwweg	190	4	was	be	VBD
cord-279343-ybncwweg	190	5	refined	refine	VBN
cord-279343-ybncwweg	190	6	in	in	IN
cord-279343-ybncwweg	190	7	CNS	CNS	NNP
cord-279343-ybncwweg	190	8	using	use	VBG
cord-279343-ybncwweg	190	9	rigid	rigid	JJ
cord-279343-ybncwweg	190	10	body	body	NN
cord-279343-ybncwweg	190	11	and	and	CC
cord-279343-ybncwweg	190	12	energy	energy	NN
cord-279343-ybncwweg	190	13	minimization	minimization	NN
cord-279343-ybncwweg	190	14	.	.	.
cord-279343-ybncwweg	191	1	Ribbon	ribbon	NN
cord-279343-ybncwweg	191	2	diagrams	diagram	NNS
cord-279343-ybncwweg	191	3	were	be	VBD
cord-279343-ybncwweg	191	4	prepared	prepare	VBN
cord-279343-ybncwweg	191	5	using	use	VBG
cord-279343-ybncwweg	191	6	the	the	DT
cord-279343-ybncwweg	191	7	program	program	NN
cord-279343-ybncwweg	191	8	MOLSCRIPT	MOLSCRIPT	NNP
cord-279343-ybncwweg	191	9	.	.	.
cord-279343-ybncwweg	192	1	41	41	CD
cord-279343-ybncwweg	193	1	Evaluating	evaluate	VBG
cord-279343-ybncwweg	193	2	potential	potential	JJ
cord-279343-ybncwweg	193	3	ligands	ligand	NNS
cord-279343-ybncwweg	193	4	of	of	IN
cord-279343-ybncwweg	193	5	DC	DC	NNP
cord-279343-ybncwweg	193	6	-	-	HYPH
cord-279343-ybncwweg	193	7	SIGN	SIGN	NNP
cord-279343-ybncwweg	193	8	/	/	SYM
cord-279343-ybncwweg	193	9	R	r	NN
cord-279343-ybncwweg	193	10	Since	since	IN
cord-279343-ybncwweg	193	11	both	both	DT
cord-279343-ybncwweg	193	12	receptors	receptor	NNS
cord-279343-ybncwweg	193	13	use	use	VBP
cord-279343-ybncwweg	193	14	multiple	multiple	JJ
cord-279343-ybncwweg	193	15	CRD	crd	NN
cord-279343-ybncwweg	193	16	domains	domain	NNS
cord-279343-ybncwweg	193	17	to	to	TO
cord-279343-ybncwweg	193	18	modulate	modulate	VB
cord-279343-ybncwweg	193	19	avidity	avidity	NN
cord-279343-ybncwweg	193	20	-	-	HYPH
cord-279343-ybncwweg	193	21	mediated	mediate	VBN
cord-279343-ybncwweg	193	22	binding	binding	NN
cord-279343-ybncwweg	193	23	to	to	IN
cord-279343-ybncwweg	193	24	various	various	JJ
cord-279343-ybncwweg	193	25	carbohydrates	carbohydrate	NNS
cord-279343-ybncwweg	193	26	found	find	VBN
cord-279343-ybncwweg	193	27	on	on	IN
cord-279343-ybncwweg	193	28	a	a	DT
cord-279343-ybncwweg	193	29	variety	variety	NN
cord-279343-ybncwweg	193	30	of	of	IN
cord-279343-ybncwweg	193	31	pathogens	pathogen	NNS
cord-279343-ybncwweg	193	32	,	,	,
cord-279343-ybncwweg	193	33	we	-PRON-	PRP
cord-279343-ybncwweg	193	34	derived	derive	VBD
cord-279343-ybncwweg	193	35	a	a	DT
cord-279343-ybncwweg	193	36	formula	formula	NN
cord-279343-ybncwweg	193	37	to	to	TO
cord-279343-ybncwweg	193	38	evaluate	evaluate	VB
cord-279343-ybncwweg	193	39	and	and	CC
cord-279343-ybncwweg	193	40	identify	identify	VB
cord-279343-ybncwweg	193	41	potential	potential	JJ
cord-279343-ybncwweg	193	42	receptor	receptor	NN
cord-279343-ybncwweg	193	43	ligands	ligand	NNS
cord-279343-ybncwweg	193	44	.	.	.
cord-279343-ybncwweg	194	1	Let	let	VB
cord-279343-ybncwweg	194	2	the	the	DT
cord-279343-ybncwweg	194	3	surface	surface	NN
cord-279343-ybncwweg	194	4	area	area	NN
cord-279343-ybncwweg	194	5	encompassed	encompass	VBN
cord-279343-ybncwweg	194	6	by	by	IN
cord-279343-ybncwweg	194	7	the	the	DT
cord-279343-ybncwweg	194	8	tetramer	tetramer	NN
cord-279343-ybncwweg	194	9	of	of	IN
cord-279343-ybncwweg	194	10	DC	DC	NNP
cord-279343-ybncwweg	194	11	-	-	HYPH
cord-279343-ybncwweg	194	12	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	194	13	CRD	crd	NN
cord-279343-ybncwweg	194	14	be	be	VBP
cord-279343-ybncwweg	194	15	S	s	NN
cord-279343-ybncwweg	194	16	o	o	NN
cord-279343-ybncwweg	194	17	,	,	,
cord-279343-ybncwweg	195	1	the	the	DT
cord-279343-ybncwweg	195	2	surface	surface	NN
cord-279343-ybncwweg	195	3	area	area	NN
cord-279343-ybncwweg	195	4	of	of	IN
cord-279343-ybncwweg	195	5	a	a	DT
cord-279343-ybncwweg	195	6	protein	protein	NN
cord-279343-ybncwweg	195	7	of	of	IN
cord-279343-ybncwweg	195	8	interest	interest	NN
cord-279343-ybncwweg	195	9	be	be	VB
cord-279343-ybncwweg	195	10	S	S	NNP
cord-279343-ybncwweg	195	11	,	,	,
cord-279343-ybncwweg	195	12	then	then	RB
cord-279343-ybncwweg	195	13	the	the	DT
cord-279343-ybncwweg	195	14	binding	binding	NN
cord-279343-ybncwweg	195	15	of	of	IN
cord-279343-ybncwweg	195	16	DC	DC	NNP
cord-279343-ybncwweg	195	17	-	-	HYPH
cord-279343-ybncwweg	195	18	SIGN	SIGN	NNP
cord-279343-ybncwweg	195	19	/	/	SYM
cord-279343-ybncwweg	195	20	R	r	NN
cord-279343-ybncwweg	195	21	requires	require	VBZ
cord-279343-ybncwweg	195	22	the	the	DT
cord-279343-ybncwweg	195	23	number	number	NN
cord-279343-ybncwweg	195	24	of	of	IN
cord-279343-ybncwweg	195	25	glycosylations	glycosylation	NNS
cord-279343-ybncwweg	195	26	N	n	CD
cord-279343-ybncwweg	195	27	satisfying	satisfying	NN
cord-279343-ybncwweg	195	28	:	:	:
cord-279343-ybncwweg	195	29	The	the	DT
cord-279343-ybncwweg	195	30	Structure	Structure	NNP
cord-279343-ybncwweg	195	31	of	of	IN
cord-279343-ybncwweg	195	32	DC	DC	NNP
cord-279343-ybncwweg	195	33	-	-	HYPH
cord-279343-ybncwweg	195	34	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	195	35	N=	N=	NNP
cord-279343-ybncwweg	196	1	SO	so	RB
cord-279343-ybncwweg	196	2	4=	4=	CD
cord-279343-ybncwweg	197	1	S	s	NN
cord-279343-ybncwweg	197	2	o	o	NN
cord-279343-ybncwweg	198	1	Thus	thus	RB
cord-279343-ybncwweg	198	2	,	,	,
cord-279343-ybncwweg	198	3	an	an	DT
cord-279343-ybncwweg	198	4	index	index	NN
cord-279343-ybncwweg	198	5	for	for	IN
cord-279343-ybncwweg	198	6	potential	potential	JJ
cord-279343-ybncwweg	198	7	ligands	ligand	NNS
cord-279343-ybncwweg	198	8	can	can	MD
cord-279343-ybncwweg	198	9	be	be	VB
cord-279343-ybncwweg	198	10	defined	define	VBN
cord-279343-ybncwweg	198	11	as	as	IN
cord-279343-ybncwweg	198	12	:	:	:
cord-279343-ybncwweg	198	13	When	when	WRB
cord-279343-ybncwweg	198	14	the	the	DT
cord-279343-ybncwweg	198	15	likelihood	likelihood	NN
cord-279343-ybncwweg	198	16	index	index	NN
cord-279343-ybncwweg	198	17	i	i	PRP
cord-279343-ybncwweg	198	18	is	be	VBZ
cord-279343-ybncwweg	198	19	greater	great	JJR
cord-279343-ybncwweg	198	20	than	than	IN
cord-279343-ybncwweg	198	21	1	1	CD
cord-279343-ybncwweg	198	22	,	,	,
cord-279343-ybncwweg	198	23	the	the	DT
cord-279343-ybncwweg	198	24	protein	protein	NN
cord-279343-ybncwweg	198	25	of	of	IN
cord-279343-ybncwweg	198	26	interest	interest	NN
cord-279343-ybncwweg	198	27	possess	possess	VBP
cord-279343-ybncwweg	198	28	,	,	,
cord-279343-ybncwweg	198	29	on	on	IN
cord-279343-ybncwweg	198	30	average	average	JJ
cord-279343-ybncwweg	198	31	,	,	,
cord-279343-ybncwweg	198	32	higher	high	JJR
cord-279343-ybncwweg	198	33	glycosylation	glycosylation	NN
cord-279343-ybncwweg	198	34	density	density	NN
cord-279343-ybncwweg	198	35	than	than	IN
cord-279343-ybncwweg	198	36	is	be	VBZ
cord-279343-ybncwweg	198	37	required	require	VBN
cord-279343-ybncwweg	198	38	for	for	IN
cord-279343-ybncwweg	198	39	binding	bind	VBG
cord-279343-ybncwweg	198	40	to	to	IN
cord-279343-ybncwweg	198	41	DC	DC	NNP
cord-279343-ybncwweg	198	42	-	-	HYPH
cord-279343-ybncwweg	198	43	SIGN	SIGN	NNP
cord-279343-ybncwweg	198	44	/	/	SYM
cord-279343-ybncwweg	198	45	R	r	NN
cord-279343-ybncwweg	198	46	and	and	CC
cord-279343-ybncwweg	198	47	,	,	,
cord-279343-ybncwweg	198	48	conversely	conversely	RB
cord-279343-ybncwweg	198	49	,	,	,
cord-279343-ybncwweg	198	50	when	when	WRB
cord-279343-ybncwweg	198	51	i	i	PRP
cord-279343-ybncwweg	198	52	is	be	VBZ
cord-279343-ybncwweg	198	53	less	less	JJR
cord-279343-ybncwweg	198	54	than	than	IN
cord-279343-ybncwweg	198	55	1	1	CD
cord-279343-ybncwweg	198	56	,	,	,
cord-279343-ybncwweg	198	57	the	the	DT
cord-279343-ybncwweg	198	58	target	target	NN
cord-279343-ybncwweg	198	59	protein	protein	NN
cord-279343-ybncwweg	198	60	is	be	VBZ
cord-279343-ybncwweg	198	61	under	under	IN
cord-279343-ybncwweg	198	62	glycosylated	glycosylate	VBN
cord-279343-ybncwweg	198	63	for	for	IN
cord-279343-ybncwweg	198	64	DC	DC	NNP
cord-279343-ybncwweg	198	65	-	-	HYPH
cord-279343-ybncwweg	198	66	SIGN	SIGN	NNP
cord-279343-ybncwweg	198	67	/	/	SYM
cord-279343-ybncwweg	198	68	R	r	NN
cord-279343-ybncwweg	198	69	binding	binding	NN
cord-279343-ybncwweg	198	70	.	.	.
cord-279343-ybncwweg	199	1	Assuming	assume	VBG
cord-279343-ybncwweg	199	2	a	a	DT
cord-279343-ybncwweg	199	3	spherical	spherical	JJ
cord-279343-ybncwweg	199	4	nature	nature	NN
cord-279343-ybncwweg	199	5	for	for	IN
cord-279343-ybncwweg	199	6	proteins	protein	NNS
cord-279343-ybncwweg	199	7	,	,	,
cord-279343-ybncwweg	199	8	which	which	WDT
cord-279343-ybncwweg	199	9	is	be	VBZ
cord-279343-ybncwweg	199	10	only	only	RB
cord-279343-ybncwweg	199	11	a	a	DT
cord-279343-ybncwweg	199	12	crude	crude	JJ
cord-279343-ybncwweg	199	13	approximation	approximation	NN
cord-279343-ybncwweg	199	14	but	but	CC
cord-279343-ybncwweg	199	15	will	will	MD
cord-279343-ybncwweg	199	16	nonetheless	nonetheless	RB
cord-279343-ybncwweg	199	17	result	result	VB
cord-279343-ybncwweg	199	18	in	in	IN
cord-279343-ybncwweg	199	19	a	a	DT
cord-279343-ybncwweg	199	20	correct	correct	JJ
cord-279343-ybncwweg	199	21	power	power	NN
cord-279343-ybncwweg	199	22	-	-	HYPH
cord-279343-ybncwweg	199	23	dependence	dependence	NN
cord-279343-ybncwweg	199	24	on	on	IN
cord-279343-ybncwweg	199	25	the	the	DT
cord-279343-ybncwweg	199	26	molecular	molecular	JJ
cord-279343-ybncwweg	199	27	mass	mass	NN
cord-279343-ybncwweg	199	28	,	,	,
cord-279343-ybncwweg	199	29	the	the	DT
cord-279343-ybncwweg	199	30	surface	surface	NN
cord-279343-ybncwweg	199	31	area	area	NN
cord-279343-ybncwweg	199	32	S	s	NN
cord-279343-ybncwweg	199	33	of	of	IN
cord-279343-ybncwweg	199	34	a	a	DT
cord-279343-ybncwweg	199	35	given	give	VBN
cord-279343-ybncwweg	199	36	protein	protein	NN
cord-279343-ybncwweg	199	37	can	can	MD
cord-279343-ybncwweg	199	38	be	be	VB
cord-279343-ybncwweg	199	39	calculated	calculate	VBN
cord-279343-ybncwweg	199	40	,	,	,
cord-279343-ybncwweg	199	41	to	to	IN
cord-279343-ybncwweg	199	42	the	the	DT
cord-279343-ybncwweg	199	43	first	first	JJ
cord-279343-ybncwweg	199	44	approximation	approximation	NN
cord-279343-ybncwweg	199	45	,	,	,
cord-279343-ybncwweg	199	46	from	from	IN
cord-279343-ybncwweg	199	47	its	-PRON-	PRP$
cord-279343-ybncwweg	199	48	molecular	molecular	JJ
cord-279343-ybncwweg	199	49	mass	mass	NN
cord-279343-ybncwweg	199	50	by	by	IN
cord-279343-ybncwweg	199	51	:	:	:
cord-279343-ybncwweg	199	52	where	where	WRB
cord-279343-ybncwweg	199	53	N	N	NNP
cord-279343-ybncwweg	199	54	A	A	NNP
cord-279343-ybncwweg	199	55	is	be	VBZ
cord-279343-ybncwweg	199	56	Avogadro	Avogadro	NNP
cord-279343-ybncwweg	199	57	's	's	POS
cord-279343-ybncwweg	199	58	constant	constant	JJ
cord-279343-ybncwweg	199	59	(	(	-LRB-
cord-279343-ybncwweg	199	60	6.022!10	6.022!10	CD
cord-279343-ybncwweg	199	61	23	23	CD
cord-279343-ybncwweg	199	62	)	)	-RRB-
cord-279343-ybncwweg	199	63	,	,	,
cord-279343-ybncwweg	199	64	M	M	NNP
cord-279343-ybncwweg	199	65	is	be	VBZ
cord-279343-ybncwweg	199	66	the	the	DT
cord-279343-ybncwweg	199	67	molecular	molecular	JJ
cord-279343-ybncwweg	199	68	mass	mass	NN
cord-279343-ybncwweg	199	69	(	(	-LRB-
cord-279343-ybncwweg	199	70	in	in	IN
cord-279343-ybncwweg	199	71	Da	Da	NNP
cord-279343-ybncwweg	199	72	)	)	-RRB-
cord-279343-ybncwweg	199	73	,	,	,
cord-279343-ybncwweg	199	74	and	and	CC
cord-279343-ybncwweg	199	75	D	D	NNP
cord-279343-ybncwweg	199	76	is	be	VBZ
cord-279343-ybncwweg	199	77	the	the	DT
cord-279343-ybncwweg	199	78	average	average	JJ
cord-279343-ybncwweg	199	79	density	density	NN
cord-279343-ybncwweg	199	80	of	of	IN
cord-279343-ybncwweg	199	81	a	a	DT
cord-279343-ybncwweg	199	82	protein	protein	NN
cord-279343-ybncwweg	199	83	,	,	,
cord-279343-ybncwweg	199	84	which	which	WDT
cord-279343-ybncwweg	199	85	has	have	VBZ
cord-279343-ybncwweg	199	86	a	a	DT
cord-279343-ybncwweg	199	87	value	value	NN
cord-279343-ybncwweg	199	88	of	of	IN
cord-279343-ybncwweg	199	89	1.3	1.3	CD
cord-279343-ybncwweg	199	90	-	-	SYM
cord-279343-ybncwweg	199	91	1.4	1.4	CD
cord-279343-ybncwweg	199	92	g	g	NN
cord-279343-ybncwweg	199	93	/	/	SYM
cord-279343-ybncwweg	199	94	ml	ml	NN
cord-279343-ybncwweg	199	95	.	.	.
cord-279343-ybncwweg	200	1	42	42	CD
cord-279343-ybncwweg	201	1	If	if	IN
cord-279343-ybncwweg	201	2	DZ1.4	DZ1.4	NNP
cord-279343-ybncwweg	201	3	g	g	NNP
cord-279343-ybncwweg	201	4	/	/	SYM
cord-279343-ybncwweg	201	5	ml	ml	NN
cord-279343-ybncwweg	201	6	is	be	VBZ
cord-279343-ybncwweg	201	7	taken	take	VBN
cord-279343-ybncwweg	201	8	and	and	CC
cord-279343-ybncwweg	201	9	equation	equation	NN
cord-279343-ybncwweg	201	10	(	(	-LRB-
cord-279343-ybncwweg	201	11	3	3	CD
cord-279343-ybncwweg	201	12	)	)	-RRB-
cord-279343-ybncwweg	201	13	is	be	VBZ
cord-279343-ybncwweg	201	14	substituted	substitute	VBN
cord-279343-ybncwweg	201	15	in	in	IN
cord-279343-ybncwweg	201	16	equation	equation	NN
cord-279343-ybncwweg	201	17	(	(	-LRB-
cord-279343-ybncwweg	201	18	2	2	CD
cord-279343-ybncwweg	201	19	)	)	-RRB-
cord-279343-ybncwweg	201	20	,	,	,
cord-279343-ybncwweg	201	21	then	then	RB
cord-279343-ybncwweg	201	22	:	:	:
cord-279343-ybncwweg	201	23	where	where	WRB
cord-279343-ybncwweg	201	24	S	s	NN
cord-279343-ybncwweg	201	25	o	o	NN
cord-279343-ybncwweg	201	26	is	be	VBZ
cord-279343-ybncwweg	201	27	in	in	IN
cord-279343-ybncwweg	201	28	Å	Å	NNP
cord-279343-ybncwweg	201	29	2	2	CD
cord-279343-ybncwweg	201	30	.	.	.
cord-279343-ybncwweg	202	1	Coordinates	coordinate	NNS
cord-279343-ybncwweg	202	2	have	have	VBP
cord-279343-ybncwweg	202	3	been	be	VBN
cord-279343-ybncwweg	202	4	deposited	deposit	VBN
cord-279343-ybncwweg	202	5	with	with	IN
cord-279343-ybncwweg	202	6	the	the	DT
cord-279343-ybncwweg	202	7	Protein	Protein	NNP
cord-279343-ybncwweg	202	8	Data	Data	NNP
cord-279343-ybncwweg	202	9	Bank	Bank	NNP
cord-279343-ybncwweg	202	10	under	under	IN
cord-279343-ybncwweg	202	11	accession	accession	NNP
cord-279343-ybncwweg	202	12	code	code	NN
cord-279343-ybncwweg	202	13	1XPH	1xph	CD
cord-279343-ybncwweg	202	14	.	.	.
cord-279343-ybncwweg	203	1	C	c	NN
cord-279343-ybncwweg	203	2	-	-	HYPH
cord-279343-ybncwweg	203	3	type	type	NN
cord-279343-ybncwweg	203	4	lectins	lectin	NNS
cord-279343-ybncwweg	203	5	DC	DC	NNP
cord-279343-ybncwweg	203	6	-	-	HYPH
cord-279343-ybncwweg	203	7	SIGN	SIGN	NNP
cord-279343-ybncwweg	203	8	and	and	CC
cord-279343-ybncwweg	203	9	L	l	NN
cord-279343-ybncwweg	203	10	-	-	HYPH
cord-279343-ybncwweg	203	11	SIGN	sign	NN
cord-279343-ybncwweg	203	12	mediate	mediate	VB
cord-279343-ybncwweg	203	13	cellular	cellular	JJ
cord-279343-ybncwweg	203	14	entry	entry	NN
cord-279343-ybncwweg	203	15	by	by	IN
cord-279343-ybncwweg	203	16	Ebola	Ebola	NNP
cord-279343-ybncwweg	203	17	virus	virus	NN
cord-279343-ybncwweg	203	18	in	in	IN
cord-279343-ybncwweg	203	19	cis	cis	NNP
cord-279343-ybncwweg	203	20	and	and	CC
cord-279343-ybncwweg	203	21	in	in	IN
cord-279343-ybncwweg	203	22	trans	trans	NNP
cord-279343-ybncwweg	203	23	HCV	HCV	NNP
cord-279343-ybncwweg	203	24	and	and	CC
cord-279343-ybncwweg	203	25	HIV	HIV	NNP
cord-279343-ybncwweg	203	26	binding	bind	VBG
cord-279343-ybncwweg	203	27	lectin	lectin	NN
cord-279343-ybncwweg	203	28	,	,	,
cord-279343-ybncwweg	203	29	DC	DC	NNP
cord-279343-ybncwweg	203	30	-	-	HYPH
cord-279343-ybncwweg	203	31	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	203	32	,	,	,
cord-279343-ybncwweg	203	33	is	be	VBZ
cord-279343-ybncwweg	203	34	expressed	express	VBN
cord-279343-ybncwweg	203	35	at	at	IN
cord-279343-ybncwweg	203	36	all	all	DT
cord-279343-ybncwweg	203	37	stages	stage	NNS
cord-279343-ybncwweg	203	38	of	of	IN
cord-279343-ybncwweg	203	39	HCV	HCV	NNP
cord-279343-ybncwweg	203	40	induced	induce	VBD
cord-279343-ybncwweg	203	41	liver	liver	NN
cord-279343-ybncwweg	203	42	disease	disease	NN
cord-279343-ybncwweg	203	43	Sequence	sequence	NN
cord-279343-ybncwweg	203	44	and	and	CC
cord-279343-ybncwweg	203	45	expression	expression	NN
cord-279343-ybncwweg	203	46	of	of	IN
cord-279343-ybncwweg	203	47	a	a	DT
cord-279343-ybncwweg	203	48	membrane	membrane	NN
cord-279343-ybncwweg	203	49	-	-	HYPH
cord-279343-ybncwweg	203	50	associated	associate	VBN
cord-279343-ybncwweg	203	51	C	c	NN
cord-279343-ybncwweg	203	52	-	-	HYPH
cord-279343-ybncwweg	203	53	type	type	NN
cord-279343-ybncwweg	203	54	lectin	lectin	NN
cord-279343-ybncwweg	203	55	that	that	WDT
cord-279343-ybncwweg	203	56	exhibits	exhibit	VBZ
cord-279343-ybncwweg	203	57	CD4-independent	cd4-independent	NN
cord-279343-ybncwweg	203	58	binding	bind	VBG
cord-279343-ybncwweg	203	59	of	of	IN
cord-279343-ybncwweg	203	60	human	human	JJ
cord-279343-ybncwweg	203	61	immunodeficiency	immunodeficiency	NN
cord-279343-ybncwweg	203	62	virus	virus	NN
cord-279343-ybncwweg	203	63	envelope	envelope	NN
cord-279343-ybncwweg	203	64	glycoprotein	glycoprotein	NN
cord-279343-ybncwweg	203	65	gp120	gp120	IN
cord-279343-ybncwweg	203	66	CD	CD	NNP
cord-279343-ybncwweg	203	67	209L	209L	NNP
cord-279343-ybncwweg	203	68	)	)	-RRB-
cord-279343-ybncwweg	203	69	is	be	VBZ
cord-279343-ybncwweg	203	70	a	a	DT
cord-279343-ybncwweg	203	71	liver	liver	NN
cord-279343-ybncwweg	203	72	-	-	HYPH
cord-279343-ybncwweg	203	73	specific	specific	JJ
cord-279343-ybncwweg	203	74	capture	capture	NN
cord-279343-ybncwweg	203	75	.	.	.
cord-279343-ybncwweg	204	1	receptor	receptor	NN
cord-279343-ybncwweg	204	2	for	for	IN
cord-279343-ybncwweg	204	3	hepatitis	hepatitis	NN
cord-279343-ybncwweg	204	4	C	C	NNP
cord-279343-ybncwweg	204	5	virus	virus	NN
cord-279343-ybncwweg	204	6	DC	DC	NNP
cord-279343-ybncwweg	204	7	-	-	HYPH
cord-279343-ybncwweg	204	8	SIGN	SIGN	NNP
cord-279343-ybncwweg	204	9	,	,	,
cord-279343-ybncwweg	204	10	a	a	DT
cord-279343-ybncwweg	204	11	dendritic	dendritic	JJ
cord-279343-ybncwweg	204	12	cell	cell	NN
cord-279343-ybncwweg	204	13	-	-	HYPH
cord-279343-ybncwweg	204	14	specific	specific	JJ
cord-279343-ybncwweg	204	15	HIV-1-binding	hiv-1-binding	NN
cord-279343-ybncwweg	204	16	protein	protein	NN
cord-279343-ybncwweg	204	17	that	that	WDT
cord-279343-ybncwweg	204	18	enhances	enhance	VBZ
cord-279343-ybncwweg	204	19	trans	trans	NN
cord-279343-ybncwweg	204	20	-	-	NN
cord-279343-ybncwweg	204	21	infection	infection	NN
cord-279343-ybncwweg	204	22	of	of	IN
cord-279343-ybncwweg	204	23	T	t	NN
cord-279343-ybncwweg	204	24	cells	cell	NNS
cord-279343-ybncwweg	204	25	Human	human	JJ
cord-279343-ybncwweg	204	26	cytomegalovirus	cytomegalovirus	NN
cord-279343-ybncwweg	204	27	binding	bind	VBG
cord-279343-ybncwweg	204	28	to	to	IN
cord-279343-ybncwweg	204	29	DC	DC	NNP
cord-279343-ybncwweg	204	30	-	-	HYPH
cord-279343-ybncwweg	204	31	SIGN	SIGN	NNP
cord-279343-ybncwweg	204	32	is	be	VBZ
cord-279343-ybncwweg	204	33	required	require	VBN
cord-279343-ybncwweg	204	34	for	for	IN
cord-279343-ybncwweg	204	35	dendritic	dendritic	JJ
cord-279343-ybncwweg	204	36	cell	cell	NN
cord-279343-ybncwweg	204	37	infection	infection	NN
cord-279343-ybncwweg	204	38	and	and	CC
cord-279343-ybncwweg	204	39	target	target	NN
cord-279343-ybncwweg	204	40	cell	cell	NN
cord-279343-ybncwweg	204	41	trans	trans	NN
cord-279343-ybncwweg	204	42	-	-	NN
cord-279343-ybncwweg	204	43	infection	infection	NN
cord-279343-ybncwweg	204	44	are	be	VBP
cord-279343-ybncwweg	204	45	high	high	JJ
cord-279343-ybncwweg	204	46	affinity	affinity	NN
cord-279343-ybncwweg	204	47	binding	bind	VBG
cord-279343-ybncwweg	204	48	receptors	receptor	NNS
cord-279343-ybncwweg	204	49	for	for	IN
cord-279343-ybncwweg	204	50	hepatitis	hepatitis	NN
cord-279343-ybncwweg	204	51	C	C	NNP
cord-279343-ybncwweg	204	52	virus	virus	NN
cord-279343-ybncwweg	204	53	glycoprotein	glycoprotein	NN
cord-279343-ybncwweg	204	54	E2	E2	NNP
cord-279343-ybncwweg	204	55	C	C	NNP
cord-279343-ybncwweg	204	56	-	-	HYPH
cord-279343-ybncwweg	204	57	type	type	NN
cord-279343-ybncwweg	204	58	Lectins	Lectins	NNP
cord-279343-ybncwweg	204	59	L	l	NN
cord-279343-ybncwweg	204	60	-	-	HYPH
cord-279343-ybncwweg	204	61	SIGN	SIGN	NNP
cord-279343-ybncwweg	204	62	and	and	CC
cord-279343-ybncwweg	204	63	DC	DC	NNP
cord-279343-ybncwweg	204	64	-	-	HYPH
cord-279343-ybncwweg	204	65	SIGN	sign	NN
cord-279343-ybncwweg	204	66	capture	capture	NN
cord-279343-ybncwweg	204	67	and	and	CC
cord-279343-ybncwweg	204	68	transmit	transmit	VB
cord-279343-ybncwweg	204	69	infectious	infectious	JJ
cord-279343-ybncwweg	204	70	hepatitis	hepatitis	NN
cord-279343-ybncwweg	204	71	C	c	NN
cord-279343-ybncwweg	204	72	virus	virus	NN
cord-279343-ybncwweg	204	73	pseudotype	pseudotype	NN
cord-279343-ybncwweg	204	74	particles	particle	NNS
cord-279343-ybncwweg	204	75	Hepatitis	Hepatitis	NNP
cord-279343-ybncwweg	204	76	C	C	NNP
cord-279343-ybncwweg	204	77	virus	virus	NN
cord-279343-ybncwweg	204	78	glycoproteins	glycoprotein	NNS
cord-279343-ybncwweg	204	79	interact	interact	VBP
cord-279343-ybncwweg	204	80	with	with	IN
cord-279343-ybncwweg	204	81	DC	DC	NNP
cord-279343-ybncwweg	204	82	-	-	HYPH
cord-279343-ybncwweg	204	83	SIGN	SIGN	NNP
cord-279343-ybncwweg	204	84	and	and	CC
cord-279343-ybncwweg	204	85	DC	DC	NNP
cord-279343-ybncwweg	204	86	-	-	HYPH
cord-279343-ybncwweg	204	87	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	204	88	DC	DC	NNP
cord-279343-ybncwweg	204	89	-	-	HYPH
cord-279343-ybncwweg	204	90	SIGN	SIGN	NNP
cord-279343-ybncwweg	204	91	and	and	CC
cord-279343-ybncwweg	204	92	DC	DC	NNP
cord-279343-ybncwweg	204	93	-	-	HYPH
cord-279343-ybncwweg	204	94	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	204	95	bind	bind	VBP
cord-279343-ybncwweg	204	96	Ebola	Ebola	NNP
cord-279343-ybncwweg	204	97	glycoproteins	glycoprotein	NNS
cord-279343-ybncwweg	204	98	and	and	CC
cord-279343-ybncwweg	204	99	enhance	enhance	VB
cord-279343-ybncwweg	204	100	infection	infection	NN
cord-279343-ybncwweg	204	101	of	of	IN
cord-279343-ybncwweg	204	102	macrophages	macrophage	NNS
cord-279343-ybncwweg	204	103	and	and	CC
cord-279343-ybncwweg	204	104	endothelial	endothelial	JJ
cord-279343-ybncwweg	204	105	cells	cell	NNS
cord-279343-ybncwweg	204	106	DC	DC	NNP
cord-279343-ybncwweg	204	107	-	-	HYPH
cord-279343-ybncwweg	204	108	SIGN	sign	NN
cord-279343-ybncwweg	204	109	:	:	:
cord-279343-ybncwweg	204	110	escape	escape	VB
cord-279343-ybncwweg	204	111	mechanism	mechanism	NN
cord-279343-ybncwweg	204	112	for	for	IN
cord-279343-ybncwweg	204	113	pathogens	pathogen	NNS
cord-279343-ybncwweg	205	1	DC	DC	NNP
cord-279343-ybncwweg	205	2	-	-	HYPH
cord-279343-ybncwweg	205	3	SIGN	sign	NN
cord-279343-ybncwweg	205	4	:	:	:
cord-279343-ybncwweg	206	1	a	a	DT
cord-279343-ybncwweg	206	2	novel	novel	JJ
cord-279343-ybncwweg	206	3	HIV	HIV	NNP
cord-279343-ybncwweg	206	4	receptor	receptor	NN
cord-279343-ybncwweg	206	5	on	on	IN
cord-279343-ybncwweg	206	6	DCs	dc	NNS
cord-279343-ybncwweg	206	7	that	that	WDT
cord-279343-ybncwweg	206	8	mediates	mediate	VBZ
cord-279343-ybncwweg	206	9	HIV-1	HIV-1	NNP
cord-279343-ybncwweg	206	10	transmission	transmission	NN
cord-279343-ybncwweg	206	11	DC	DC	NNP
cord-279343-ybncwweg	206	12	-	-	HYPH
cord-279343-ybncwweg	206	13	SIGN	SIGN	NNP
cord-279343-ybncwweg	206	14	promotes	promote	VBZ
cord-279343-ybncwweg	206	15	exogenous	exogenous	JJ
cord-279343-ybncwweg	206	16	MHC	MHC	NNP
cord-279343-ybncwweg	206	17	-	-	HYPH
cord-279343-ybncwweg	206	18	I	I	NNP
cord-279343-ybncwweg	206	19	-	-	HYPH
cord-279343-ybncwweg	206	20	restricted	restrict	VBN
cord-279343-ybncwweg	206	21	HIV-1	HIV-1	NNP
cord-279343-ybncwweg	206	22	antigen	antigen	NN
cord-279343-ybncwweg	206	23	presentation	presentation	NN
cord-279343-ybncwweg	206	24	DC	DC	NNP
cord-279343-ybncwweg	206	25	-	-	HYPH
cord-279343-ybncwweg	206	26	SIGN	SIGN	NNP
cord-279343-ybncwweg	206	27	homologue	homologue	NN
cord-279343-ybncwweg	206	28	expressed	express	VBN
cord-279343-ybncwweg	206	29	in	in	IN
cord-279343-ybncwweg	206	30	endothelial	endothelial	JJ
cord-279343-ybncwweg	206	31	cells	cell	NNS
cord-279343-ybncwweg	206	32	,	,	,
cord-279343-ybncwweg	206	33	binds	bind	VBZ
cord-279343-ybncwweg	206	34	to	to	IN
cord-279343-ybncwweg	206	35	human	human	JJ
cord-279343-ybncwweg	206	36	and	and	CC
cord-279343-ybncwweg	206	37	simian	simian	JJ
cord-279343-ybncwweg	206	38	immunodeficiency	immunodeficiency	NN
cord-279343-ybncwweg	206	39	viruses	virus	NNS
cord-279343-ybncwweg	206	40	and	and	CC
cord-279343-ybncwweg	206	41	activates	activate	VBZ
cord-279343-ybncwweg	206	42	infection	infection	NN
cord-279343-ybncwweg	206	43	in	in	IN
cord-279343-ybncwweg	206	44	trans	trans	NNP
cord-279343-ybncwweg	206	45	DC	DC	NNP
cord-279343-ybncwweg	206	46	-	-	HYPH
cord-279343-ybncwweg	206	47	SIGN	SIGN	NNP
cord-279343-ybncwweg	206	48	;	;	:
cord-279343-ybncwweg	206	49	a	a	DT
cord-279343-ybncwweg	206	50	related	relate	VBN
cord-279343-ybncwweg	206	51	gene	gene	NN
cord-279343-ybncwweg	206	52	,	,	,
cord-279343-ybncwweg	206	53	DC	DC	NNP
cord-279343-ybncwweg	206	54	-	-	HYPH
cord-279343-ybncwweg	206	55	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	206	56	;	;	:
cord-279343-ybncwweg	206	57	and	and	CC
cord-279343-ybncwweg	206	58	CD23	CD23	NNP
cord-279343-ybncwweg	206	59	form	form	VB
cord-279343-ybncwweg	206	60	a	a	DT
cord-279343-ybncwweg	206	61	cluster	cluster	NN
cord-279343-ybncwweg	206	62	on	on	IN
cord-279343-ybncwweg	206	63	19p13	19p13	CD
cord-279343-ybncwweg	207	1	A	a	DT
cord-279343-ybncwweg	207	2	dendritic	dendritic	JJ
cord-279343-ybncwweg	207	3	cell	cell	NN
cord-279343-ybncwweg	207	4	-	-	HYPH
cord-279343-ybncwweg	207	5	specific	specific	JJ
cord-279343-ybncwweg	207	6	intercellular	intercellular	JJ
cord-279343-ybncwweg	207	7	adhesion	adhesion	NN
cord-279343-ybncwweg	207	8	molecule	molecule	NN
cord-279343-ybncwweg	207	9	3-grabbing	3-grabbing	CD
cord-279343-ybncwweg	207	10	nonintegrin	nonintegrin	NNP
cord-279343-ybncwweg	207	11	(	(	-LRB-
cord-279343-ybncwweg	207	12	DC	DC	NNP
cord-279343-ybncwweg	207	13	-	-	HYPH
cord-279343-ybncwweg	207	14	SIGN)-related	SIGN)-related	NNP
cord-279343-ybncwweg	207	15	protein	protein	NN
cord-279343-ybncwweg	207	16	is	be	VBZ
cord-279343-ybncwweg	207	17	highly	highly	RB
cord-279343-ybncwweg	207	18	expressed	express	VBN
cord-279343-ybncwweg	207	19	on	on	IN
cord-279343-ybncwweg	207	20	human	human	JJ
cord-279343-ybncwweg	207	21	liver	liver	NN
cord-279343-ybncwweg	207	22	sinusoidal	sinusoidal	NN
cord-279343-ybncwweg	207	23	endothelial	endothelial	JJ
cord-279343-ybncwweg	207	24	cells	cell	NNS
cord-279343-ybncwweg	207	25	and	and	CC
cord-279343-ybncwweg	207	26	promotes	promote	VBZ
cord-279343-ybncwweg	207	27	HIV-1	HIV-1	NNP
cord-279343-ybncwweg	207	28	infection	infection	NN
cord-279343-ybncwweg	207	29	A	a	DT
cord-279343-ybncwweg	207	30	novel	novel	JJ
cord-279343-ybncwweg	207	31	mechanism	mechanism	NN
cord-279343-ybncwweg	207	32	of	of	IN
cord-279343-ybncwweg	207	33	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	207	34	recognition	recognition	NN
cord-279343-ybncwweg	207	35	by	by	IN
cord-279343-ybncwweg	207	36	the	the	DT
cord-279343-ybncwweg	207	37	C	c	NN
cord-279343-ybncwweg	207	38	-	-	HYPH
cord-279343-ybncwweg	207	39	type	type	NN
cord-279343-ybncwweg	207	40	lectins	lectin	NNS
cord-279343-ybncwweg	207	41	DC	DC	NNP
cord-279343-ybncwweg	207	42	-	-	HYPH
cord-279343-ybncwweg	207	43	SIGN	SIGN	NNP
cord-279343-ybncwweg	207	44	and	and	CC
cord-279343-ybncwweg	207	45	DC	DC	NNP
cord-279343-ybncwweg	207	46	-	-	HYPH
cord-279343-ybncwweg	207	47	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	207	48	.	.	.
cord-279343-ybncwweg	208	1	Subunit	subunit	NN
cord-279343-ybncwweg	208	2	organization	organization	NN
cord-279343-ybncwweg	208	3	and	and	CC
cord-279343-ybncwweg	208	4	binding	bind	VBG
cord-279343-ybncwweg	208	5	to	to	IN
cord-279343-ybncwweg	208	6	multivalent	multivalent	JJ
cord-279343-ybncwweg	208	7	ligands	ligand	NNS
cord-279343-ybncwweg	208	8	Structural	structural	JJ
cord-279343-ybncwweg	208	9	basis	basis	NN
cord-279343-ybncwweg	208	10	for	for	IN
cord-279343-ybncwweg	208	11	selective	selective	JJ
cord-279343-ybncwweg	208	12	recognition	recognition	NN
cord-279343-ybncwweg	208	13	of	of	IN
cord-279343-ybncwweg	208	14	oligosaccharides	oligosaccharide	NNS
cord-279343-ybncwweg	208	15	by	by	IN
cord-279343-ybncwweg	208	16	DC	DC	NNP
cord-279343-ybncwweg	208	17	-	-	HYPH
cord-279343-ybncwweg	208	18	SIGN	SIGN	NNP
cord-279343-ybncwweg	208	19	and	and	CC
cord-279343-ybncwweg	208	20	DC	DC	NNP
cord-279343-ybncwweg	208	21	-	-	HYPH
cord-279343-ybncwweg	208	22	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	208	23	Structural	structural	JJ
cord-279343-ybncwweg	208	24	basis	basis	NN
cord-279343-ybncwweg	208	25	for	for	IN
cord-279343-ybncwweg	208	26	distinct	distinct	JJ
cord-279343-ybncwweg	208	27	ligand	ligand	NN
cord-279343-ybncwweg	208	28	-	-	HYPH
cord-279343-ybncwweg	208	29	binding	bind	VBG
cord-279343-ybncwweg	208	30	and	and	CC
cord-279343-ybncwweg	208	31	targeting	target	VBG
cord-279343-ybncwweg	208	32	properties	property	NNS
cord-279343-ybncwweg	208	33	of	of	IN
cord-279343-ybncwweg	208	34	the	the	DT
cord-279343-ybncwweg	208	35	receptors	receptor	NNS
cord-279343-ybncwweg	208	36	DC	DC	NNP
cord-279343-ybncwweg	208	37	-	-	HYPH
cord-279343-ybncwweg	208	38	SIGN	SIGN	NNP
cord-279343-ybncwweg	208	39	and	and	CC
cord-279343-ybncwweg	208	40	DC	DC	NNP
cord-279343-ybncwweg	208	41	-	-	HYPH
cord-279343-ybncwweg	208	42	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	208	43	Contribution	Contribution	NNP
cord-279343-ybncwweg	208	44	to	to	TO
cord-279343-ybncwweg	208	45	ligand	ligand	NN
cord-279343-ybncwweg	208	46	binding	binding	NN
cord-279343-ybncwweg	208	47	by	by	IN
cord-279343-ybncwweg	208	48	multiple	multiple	JJ
cord-279343-ybncwweg	208	49	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	208	50	-	-	HYPH
cord-279343-ybncwweg	208	51	recognition	recognition	NN
cord-279343-ybncwweg	208	52	domains	domain	NNS
cord-279343-ybncwweg	208	53	in	in	IN
cord-279343-ybncwweg	208	54	the	the	DT
cord-279343-ybncwweg	208	55	macrophage	macrophage	NN
cord-279343-ybncwweg	208	56	mannose	mannose	NN
cord-279343-ybncwweg	208	57	receptor	receptor	NN
cord-279343-ybncwweg	208	58	Characterization	characterization	NN
cord-279343-ybncwweg	208	59	of	of	IN
cord-279343-ybncwweg	208	60	DC	DC	NNP
cord-279343-ybncwweg	208	61	-	-	HYPH
cord-279343-ybncwweg	208	62	SIGN	SIGN	NNP
cord-279343-ybncwweg	208	63	/	/	SYM
cord-279343-ybncwweg	208	64	R	r	NN
cord-279343-ybncwweg	208	65	interaction	interaction	NN
cord-279343-ybncwweg	208	66	with	with	IN
cord-279343-ybncwweg	208	67	HIV-1	HIV-1	NNP
cord-279343-ybncwweg	208	68	gp120	gp120	NNP
cord-279343-ybncwweg	208	69	and	and	CC
cord-279343-ybncwweg	208	70	ICAM	ICAM	NNP
cord-279343-ybncwweg	208	71	molecules	molecule	NNS
cord-279343-ybncwweg	208	72	favors	favor	VBZ
cord-279343-ybncwweg	208	73	the	the	DT
cord-279343-ybncwweg	208	74	receptor	receptor	NN
cord-279343-ybncwweg	208	75	's	's	POS
cord-279343-ybncwweg	208	76	role	role	NN
cord-279343-ybncwweg	208	77	as	as	IN
cord-279343-ybncwweg	208	78	an	an	DT
cord-279343-ybncwweg	208	79	antigen	antigen	NN
cord-279343-ybncwweg	208	80	capturing	capture	VBG
cord-279343-ybncwweg	208	81	rather	rather	RB
cord-279343-ybncwweg	208	82	than	than	IN
cord-279343-ybncwweg	208	83	adhesion	adhesion	NN
cord-279343-ybncwweg	208	84	receptor	receptor	NN
cord-279343-ybncwweg	208	85	Extended	extend	VBN
cord-279343-ybncwweg	208	86	neck	neck	NN
cord-279343-ybncwweg	208	87	regions	region	NNS
cord-279343-ybncwweg	208	88	stabilize	stabilize	VBP
cord-279343-ybncwweg	208	89	tetramers	tetramer	NNS
cord-279343-ybncwweg	208	90	of	of	IN
cord-279343-ybncwweg	208	91	the	the	DT
cord-279343-ybncwweg	208	92	receptors	receptor	NNS
cord-279343-ybncwweg	208	93	DC	DC	NNP
cord-279343-ybncwweg	208	94	-	-	HYPH
cord-279343-ybncwweg	208	95	SIGN	SIGN	NNP
cord-279343-ybncwweg	208	96	and	and	CC
cord-279343-ybncwweg	208	97	DC	DC	NNP
cord-279343-ybncwweg	208	98	-	-	HYPH
cord-279343-ybncwweg	208	99	SIGNR	SIGNR	NNP
cord-279343-ybncwweg	208	100	C	c	NN
cord-279343-ybncwweg	208	101	-	-	HYPH
cord-279343-ybncwweg	208	102	type	type	NN
cord-279343-ybncwweg	208	103	lectin	lectin	NN
cord-279343-ybncwweg	208	104	-	-	HYPH
cord-279343-ybncwweg	208	105	like	like	JJ
cord-279343-ybncwweg	208	106	domains	domain	NNS
cord-279343-ybncwweg	208	107	Structure	Structure	NNP
cord-279343-ybncwweg	208	108	of	of	IN
cord-279343-ybncwweg	208	109	a	a	DT
cord-279343-ybncwweg	208	110	C	c	NN
cord-279343-ybncwweg	208	111	-	-	HYPH
cord-279343-ybncwweg	208	112	type	type	NN
cord-279343-ybncwweg	208	113	carbohydrate	carbohydrate	NN
cord-279343-ybncwweg	208	114	recognition	recognition	NN
cord-279343-ybncwweg	208	115	domain	domain	NN
cord-279343-ybncwweg	208	116	from	from	IN
cord-279343-ybncwweg	208	117	the	the	DT
cord-279343-ybncwweg	208	118	macrophage	macrophage	NN
cord-279343-ybncwweg	208	119	mannose	mannose	NN
cord-279343-ybncwweg	208	120	receptor	receptor	NN
cord-279343-ybncwweg	208	121	Collectin	Collectin	NNP
cord-279343-ybncwweg	208	122	structure	structure	NN
cord-279343-ybncwweg	208	123	:	:	:
cord-279343-ybncwweg	208	124	a	a	DT
cord-279343-ybncwweg	208	125	review	review	NN
cord-279343-ybncwweg	209	1	Oligolysinebased	oligolysinebased	JJ
cord-279343-ybncwweg	209	2	oligosaccharide	oligosaccharide	NN
cord-279343-ybncwweg	209	3	clusters	cluster	NNS
cord-279343-ybncwweg	209	4	:	:	:
cord-279343-ybncwweg	209	5	selective	selective	JJ
cord-279343-ybncwweg	209	6	recognition	recognition	NN
cord-279343-ybncwweg	209	7	and	and	CC
cord-279343-ybncwweg	209	8	endocytosis	endocytosis	NN
cord-279343-ybncwweg	209	9	by	by	IN
cord-279343-ybncwweg	209	10	the	the	DT
cord-279343-ybncwweg	209	11	mannose	mannose	NN
cord-279343-ybncwweg	209	12	receptor	receptor	NN
cord-279343-ybncwweg	209	13	and	and	CC
cord-279343-ybncwweg	209	14	dendritic	dendritic	JJ
cord-279343-ybncwweg	209	15	cell	cell	NN
cord-279343-ybncwweg	209	16	-	-	HYPH
cord-279343-ybncwweg	209	17	specific	specific	JJ
cord-279343-ybncwweg	209	18	intercellular	intercellular	JJ
cord-279343-ybncwweg	209	19	adhesion	adhesion	NN
cord-279343-ybncwweg	209	20	molecule	molecule	NN
cord-279343-ybncwweg	209	21	3	3	CD
cord-279343-ybncwweg	210	1	(	(	-LRB-
cord-279343-ybncwweg	210	2	ICAM-3)-grabbing	icam-3)-grabbe	VBG
cord-279343-ybncwweg	210	3	nonintegrin	nonintegrin	NNP
cord-279343-ybncwweg	210	4	Novel	Novel	NNP
cord-279343-ybncwweg	210	5	member	member	NN
cord-279343-ybncwweg	210	6	of	of	IN
cord-279343-ybncwweg	210	7	the	the	DT
cord-279343-ybncwweg	210	8	CD209	CD209	NNP
cord-279343-ybncwweg	210	9	(	(	-LRB-
cord-279343-ybncwweg	210	10	DC	DC	NNP
cord-279343-ybncwweg	210	11	-	-	HYPH
cord-279343-ybncwweg	210	12	SIGN	SIGN	NNP
cord-279343-ybncwweg	210	13	)	)	-RRB-
cord-279343-ybncwweg	211	1	gene	gene	NN
cord-279343-ybncwweg	211	2	family	family	NN
cord-279343-ybncwweg	211	3	in	in	IN
cord-279343-ybncwweg	211	4	primates	primate	NNS
cord-279343-ybncwweg	212	1	Dendritic	dendritic	JJ
cord-279343-ybncwweg	212	2	-	-	HYPH
cord-279343-ybncwweg	212	3	cell	cell	NN
cord-279343-ybncwweg	212	4	-	-	HYPH
cord-279343-ybncwweg	212	5	specific	specific	JJ
cord-279343-ybncwweg	212	6	ICAM3-grabbing	icam3-grabbing	FW
cord-279343-ybncwweg	212	7	non	non	JJ
cord-279343-ybncwweg	212	8	-	-	JJ
cord-279343-ybncwweg	212	9	integrin	integrin	JJ
cord-279343-ybncwweg	212	10	is	be	VBZ
cord-279343-ybncwweg	212	11	essential	essential	JJ
cord-279343-ybncwweg	212	12	for	for	IN
cord-279343-ybncwweg	212	13	the	the	DT
cord-279343-ybncwweg	212	14	productive	productive	JJ
cord-279343-ybncwweg	212	15	infection	infection	NN
cord-279343-ybncwweg	212	16	of	of	IN
cord-279343-ybncwweg	212	17	human	human	JJ
cord-279343-ybncwweg	212	18	dendritic	dendritic	JJ
cord-279343-ybncwweg	212	19	cells	cell	NNS
cord-279343-ybncwweg	212	20	by	by	IN
cord-279343-ybncwweg	212	21	mosquito	mosquito	NN
cord-279343-ybncwweg	212	22	-	-	HYPH
cord-279343-ybncwweg	212	23	cell	cell	NN
cord-279343-ybncwweg	212	24	-	-	HYPH
cord-279343-ybncwweg	212	25	derived	derive	VBN
cord-279343-ybncwweg	212	26	dengue	dengue	NN
cord-279343-ybncwweg	212	27	viruses	virus	NNS
cord-279343-ybncwweg	212	28	CD209	cd209	VBP
cord-279343-ybncwweg	212	29	)	)	-RRB-
cord-279343-ybncwweg	212	30	mediates	mediate	VBZ
cord-279343-ybncwweg	212	31	dengue	dengue	NN
cord-279343-ybncwweg	212	32	virus	virus	NN
cord-279343-ybncwweg	212	33	infection	infection	NN
cord-279343-ybncwweg	212	34	of	of	IN
cord-279343-ybncwweg	212	35	human	human	JJ
cord-279343-ybncwweg	212	36	dendritic	dendritic	JJ
cord-279343-ybncwweg	212	37	cells	cell	NNS
cord-279343-ybncwweg	212	38	Variable	variable	JJ
cord-279343-ybncwweg	212	39	surface	surface	NN
cord-279343-ybncwweg	212	40	epitopes	epitope	NNS
cord-279343-ybncwweg	212	41	in	in	IN
cord-279343-ybncwweg	212	42	the	the	DT
cord-279343-ybncwweg	212	43	crystal	crystal	JJ
cord-279343-ybncwweg	212	44	structure	structure	NN
cord-279343-ybncwweg	212	45	of	of	IN
cord-279343-ybncwweg	212	46	dengue	dengue	NN
cord-279343-ybncwweg	212	47	virus	virus	NN
cord-279343-ybncwweg	212	48	type	type	NN
cord-279343-ybncwweg	212	49	3	3	CD
cord-279343-ybncwweg	212	50	envelope	envelope	NN
cord-279343-ybncwweg	212	51	glycoprotein	glycoprotein	VBG
cord-279343-ybncwweg	212	52	A	a	DT
cord-279343-ybncwweg	212	53	ligand	ligand	NN
cord-279343-ybncwweg	212	54	-	-	HYPH
cord-279343-ybncwweg	212	55	binding	bind	VBG
cord-279343-ybncwweg	212	56	pocket	pocket	NN
cord-279343-ybncwweg	212	57	in	in	IN
cord-279343-ybncwweg	212	58	the	the	DT
cord-279343-ybncwweg	212	59	dengue	dengue	NN
cord-279343-ybncwweg	212	60	virus	virus	NN
cord-279343-ybncwweg	212	61	envelope	envelope	NN
cord-279343-ybncwweg	212	62	glycoprotein	glycoprotein	VBG
cord-279343-ybncwweg	212	63	Comparative	Comparative	NNP
cord-279343-ybncwweg	212	64	studies	study	NNS
cord-279343-ybncwweg	212	65	of	of	IN
cord-279343-ybncwweg	212	66	protein	protein	NN
cord-279343-ybncwweg	212	67	crystallization	crystallization	NN
cord-279343-ybncwweg	212	68	by	by	IN
cord-279343-ybncwweg	212	69	vapour	vapour	NN
cord-279343-ybncwweg	212	70	-	-	HYPH
cord-279343-ybncwweg	212	71	diffusion	diffusion	NN
cord-279343-ybncwweg	212	72	and	and	CC
cord-279343-ybncwweg	212	73	microbatch	microbatch	NN
cord-279343-ybncwweg	212	74	techniques	technique	NNS
cord-279343-ybncwweg	213	1	The	the	DT
cord-279343-ybncwweg	213	2	role	role	NN
cord-279343-ybncwweg	213	3	of	of	IN
cord-279343-ybncwweg	213	4	oil	oil	NN
cord-279343-ybncwweg	213	5	in	in	IN
cord-279343-ybncwweg	213	6	macromolecular	macromolecular	JJ
cord-279343-ybncwweg	213	7	crystallization	crystallization	NN
cord-279343-ybncwweg	214	1	The	the	DT
cord-279343-ybncwweg	214	2	CCP4	CCP4	NNP
cord-279343-ybncwweg	214	3	suite	suite	NN
cord-279343-ybncwweg	214	4	:	:	:
cord-279343-ybncwweg	214	5	programs	program	NNS
cord-279343-ybncwweg	214	6	for	for	IN
cord-279343-ybncwweg	214	7	protein	protein	NN
cord-279343-ybncwweg	214	8	crystallography	crystallography	NN
cord-279343-ybncwweg	214	9	Crystallography	Crystallography	NNP
cord-279343-ybncwweg	214	10	&	&	CC
cord-279343-ybncwweg	214	11	NMR	NMR	NNP
cord-279343-ybncwweg	214	12	system	system	NN
cord-279343-ybncwweg	214	13	:	:	:
cord-279343-ybncwweg	214	14	A	a	DT
cord-279343-ybncwweg	214	15	new	new	JJ
cord-279343-ybncwweg	214	16	software	software	NN
cord-279343-ybncwweg	214	17	suite	suite	NN
cord-279343-ybncwweg	214	18	for	for	IN
cord-279343-ybncwweg	214	19	macromolecular	macromolecular	JJ
cord-279343-ybncwweg	214	20	structure	structure	NN
cord-279343-ybncwweg	214	21	determination	determination	NN
cord-279343-ybncwweg	214	22	PROCHECK	PROCHECK	NNP
cord-279343-ybncwweg	214	23	:	:	:
cord-279343-ybncwweg	214	24	a	a	DT
cord-279343-ybncwweg	214	25	program	program	NN
cord-279343-ybncwweg	214	26	to	to	TO
cord-279343-ybncwweg	214	27	check	check	VB
cord-279343-ybncwweg	214	28	the	the	DT
cord-279343-ybncwweg	214	29	stereochemical	stereochemical	JJ
cord-279343-ybncwweg	214	30	quality	quality	NN
cord-279343-ybncwweg	214	31	of	of	IN
cord-279343-ybncwweg	214	32	protein	protein	NN
cord-279343-ybncwweg	214	33	structures	structure	NNS
cord-279343-ybncwweg	214	34	Not	not	RB
cord-279343-ybncwweg	214	35	your	-PRON-	PRP$
cord-279343-ybncwweg	214	36	average	average	JJ
cord-279343-ybncwweg	214	37	density	density	NN
cord-279343-ybncwweg	214	38	Basic	basic	JJ
cord-279343-ybncwweg	214	39	local	local	JJ
cord-279343-ybncwweg	214	40	alignment	alignment	NN
cord-279343-ybncwweg	214	41	search	search	NN
cord-279343-ybncwweg	214	42	tool	tool	NN
cord-279343-ybncwweg	214	43	Improved	improve	VBN
cord-279343-ybncwweg	214	44	methods	method	NNS
cord-279343-ybncwweg	214	45	for	for	IN
cord-279343-ybncwweg	214	46	building	build	VBG
cord-279343-ybncwweg	214	47	protein	protein	NN
cord-279343-ybncwweg	214	48	models	model	NNS
cord-279343-ybncwweg	214	49	in	in	IN
cord-279343-ybncwweg	214	50	electron	electron	NN
cord-279343-ybncwweg	214	51	density	density	NN
cord-279343-ybncwweg	214	52	maps	map	NNS
cord-279343-ybncwweg	214	53	and	and	CC
cord-279343-ybncwweg	214	54	the	the	DT
cord-279343-ybncwweg	214	55	location	location	NN
cord-279343-ybncwweg	214	56	of	of	IN
cord-279343-ybncwweg	214	57	errors	error	NNS
cord-279343-ybncwweg	214	58	in	in	IN
cord-279343-ybncwweg	214	59	these	these	DT
cord-279343-ybncwweg	214	60	models	model	NNS
cord-279343-ybncwweg	215	1	MOLSCRIPT	MOLSCRIPT	NNP
cord-279343-ybncwweg	215	2	:	:	:
cord-279343-ybncwweg	215	3	a	a	DT
cord-279343-ybncwweg	215	4	program	program	NN
cord-279343-ybncwweg	215	5	to	to	TO
cord-279343-ybncwweg	215	6	produce	produce	VB
cord-279343-ybncwweg	215	7	both	both	DT
cord-279343-ybncwweg	215	8	detailed	detailed	JJ
cord-279343-ybncwweg	215	9	and	and	CC
cord-279343-ybncwweg	215	10	schematic	schematic	JJ
cord-279343-ybncwweg	215	11	plots	plot	NNS
cord-279343-ybncwweg	215	12	of	of	IN
cord-279343-ybncwweg	215	13	protein	protein	NN
cord-279343-ybncwweg	215	14	structures	structure	NNS
cord-279343-ybncwweg	215	15	On	on	IN
cord-279343-ybncwweg	215	16	the	the	DT
cord-279343-ybncwweg	215	17	nature	nature	NN
cord-279343-ybncwweg	215	18	of	of	IN
cord-279343-ybncwweg	215	19	the	the	DT
cord-279343-ybncwweg	215	20	protein	protein	NN
cord-279343-ybncwweg	215	21	interior	interior	NN
cord-279343-ybncwweg	216	1	We	-PRON-	PRP
cord-279343-ybncwweg	216	2	thank	thank	VBP
cord-279343-ybncwweg	216	3	C.	C.	NNP
cord-279343-ybncwweg	216	4	Hammer	Hammer	NNP
cord-279343-ybncwweg	216	5	for	for	IN
cord-279343-ybncwweg	216	6	mass	mass	NN
cord-279343-ybncwweg	216	7	spectrometry	spectrometry	NN
cord-279343-ybncwweg	216	8	,	,	,
cord-279343-ybncwweg	216	9	M.	M.	NNP
cord-279343-ybncwweg	216	10	Garfield	Garfield	NNP
cord-279343-ybncwweg	216	11	for	for	IN
cord-279343-ybncwweg	216	12	N	n	CD
cord-279343-ybncwweg	216	13	-	-	HYPH
cord-279343-ybncwweg	216	14	terminal	terminal	NN
cord-279343-ybncwweg	216	15	sequencing	sequencing	NN
cord-279343-ybncwweg	216	16	,	,	,
cord-279343-ybncwweg	216	17	B.	B.	NNP
cord-279343-ybncwweg	216	18	Hagos	Hagos	NNP
cord-279343-ybncwweg	216	19	for	for	IN
cord-279343-ybncwweg	216	20	assistance	assistance	NN
cord-279343-ybncwweg	216	21	with	with	IN
cord-279343-ybncwweg	216	22	protein	protein	NN
cord-279343-ybncwweg	216	23	expression	expression	NN
cord-279343-ybncwweg	216	24	,	,	,
cord-279343-ybncwweg	216	25	and	and	CC
cord-279343-ybncwweg	216	26	C.	C.	NNP
cord-279343-ybncwweg	216	27	Foster	Foster	NNP
cord-279343-ybncwweg	216	28	,	,	,
cord-279343-ybncwweg	216	29	A.	A.	NNP
cord-279343-ybncwweg	216	30	Johnson	Johnson	NNP
cord-279343-ybncwweg	216	31	,	,	,
cord-279343-ybncwweg	216	32	Z.	Z.	NNP
cord-279343-ybncwweg	216	33	Lu	Lu	NNP
cord-279343-ybncwweg	216	34	,	,	,
cord-279343-ybncwweg	216	35	S.	S.	NNP
cord-279343-ybncwweg	216	36	Ginell	Ginell	NNP
cord-279343-ybncwweg	216	37	,	,	,
cord-279343-ybncwweg	216	38	and	and	CC
cord-279343-ybncwweg	216	39	N.	N.	NNP
cord-279343-ybncwweg	216	40	Duke	Duke	NNP
cord-279343-ybncwweg	216	41	for	for	IN
cord-279343-ybncwweg	216	42	assistance	assistance	NN
cord-279343-ybncwweg	216	43	with	with	IN
cord-279343-ybncwweg	216	44	synchrotron	synchrotron	NN
cord-279343-ybncwweg	216	45	data	data	NN
cord-279343-ybncwweg	216	46	collection	collection	NN
cord-279343-ybncwweg	216	47	.	.	.
cord-279343-ybncwweg	217	1	We	-PRON-	PRP
cord-279343-ybncwweg	217	2	thank	thank	VBP
cord-279343-ybncwweg	217	3	J.	J.	NNP
cord-279343-ybncwweg	217	4	Arthos	Arthos	NNP
cord-279343-ybncwweg	217	5	for	for	IN
cord-279343-ybncwweg	217	6	helpful	helpful	JJ
cord-279343-ybncwweg	217	7	discussions	discussion	NNS
cord-279343-ybncwweg	217	8	.	.	.
cord-279343-ybncwweg	218	1	We	-PRON-	PRP
cord-279343-ybncwweg	218	2	thank	thank	VBP
cord-279343-ybncwweg	218	3	C.	C.	NNP
cord-279343-ybncwweg	218	4	Foster	Foster	NNP
cord-279343-ybncwweg	218	5	,	,	,
cord-279343-ybncwweg	218	6	S.	S.	NNP
cord-279343-ybncwweg	218	7	Garman	Garman	NNP
cord-279343-ybncwweg	218	8	and	and	CC
cord-279343-ybncwweg	218	9	S.	S.	NNP
cord-279343-ybncwweg	218	10	Radaev	Radaev	NNP
cord-279343-ybncwweg	218	11	for	for	IN
cord-279343-ybncwweg	218	12	helpful	helpful	JJ
cord-279343-ybncwweg	218	13	comments	comment	NNS
cord-279343-ybncwweg	218	14	with	with	IN
cord-279343-ybncwweg	218	15	structure	structure	NN
cord-279343-ybncwweg	218	16	and	and	CC
cord-279343-ybncwweg	218	17	manuscript	manuscript	NN
cord-279343-ybncwweg	218	18	.	.	.
cord-279343-ybncwweg	219	1	Use	Use	NNP
cord-279343-ybncwweg	219	2	of	of	IN
cord-279343-ybncwweg	219	3	the	the	DT
cord-279343-ybncwweg	219	4	Argonne	Argonne	NNP
cord-279343-ybncwweg	219	5	National	National	NNP
cord-279343-ybncwweg	219	6	Laboratory	Laboratory	NNP
cord-279343-ybncwweg	219	7	Structural	Structural	NNP
cord-279343-ybncwweg	219	8	Biology	Biology	NNP
cord-279343-ybncwweg	219	9	Center	Center	NNP
cord-279343-ybncwweg	219	10	beamlines	beamline	NNS
cord-279343-ybncwweg	219	11	at	at	IN
cord-279343-ybncwweg	219	12	the	the	DT
cord-279343-ybncwweg	219	13	Advanced	Advanced	NNP
cord-279343-ybncwweg	219	14	Photon	Photon	NNP
cord-279343-ybncwweg	219	15	Source	Source	NNP
cord-279343-ybncwweg	219	16	was	be	VBD
cord-279343-ybncwweg	219	17	supported	support	VBN
cord-279343-ybncwweg	219	18	by	by	IN
cord-279343-ybncwweg	219	19	the	the	DT
cord-279343-ybncwweg	219	20	US	US	NNP
cord-279343-ybncwweg	219	21	Department	Department	NNP
cord-279343-ybncwweg	219	22	of	of	IN
cord-279343-ybncwweg	219	23	Energy	Energy	NNP
cord-279343-ybncwweg	219	24	,	,	,
cord-279343-ybncwweg	219	25	Office	Office	NNP
cord-279343-ybncwweg	219	26	of	of	IN
cord-279343-ybncwweg	219	27	Energy	Energy	NNP
cord-279343-ybncwweg	219	28	Research	Research	NNP
cord-279343-ybncwweg	219	29	,	,	,
cord-279343-ybncwweg	219	30	under	under	IN
cord-279343-ybncwweg	219	31	Contract	Contract	NNP
cord-279343-ybncwweg	219	32	no	no	NN
cord-279343-ybncwweg	219	33	.	.	.
cord-279343-ybncwweg	219	34	W-31	W-31	NNP
cord-279343-ybncwweg	219	35	-	-	HYPH
cord-279343-ybncwweg	219	36	109-ENG-38	109-eng-38	CD
cord-279343-ybncwweg	219	37	.	.	.
cord-279343-ybncwweg	220	1	This	this	DT
cord-279343-ybncwweg	220	2	work	work	NN
cord-279343-ybncwweg	220	3	was	be	VBD
cord-279343-ybncwweg	220	4	supported	support	VBN
cord-279343-ybncwweg	220	5	by	by	IN
cord-279343-ybncwweg	220	6	NIAID	NIAID	NNP
cord-279343-ybncwweg	220	7	intramural	intramural	JJ
cord-279343-ybncwweg	220	8	funding	funding	NN
cord-279343-ybncwweg	220	9	.	.	.