id sid tid token lemma pos cord-018103-czjjnlkf 1 1 key key NN cord-018103-czjjnlkf 1 2 : : : cord-018103-czjjnlkf 1 3 cord-018103-czjjnlkf cord-018103-czjjnlkf NNP cord-018103-czjjnlkf 2 1 authors author NNS cord-018103-czjjnlkf 2 2 : : : cord-018103-czjjnlkf 2 3 Moon Moon NNP cord-018103-czjjnlkf 2 4 , , , cord-018103-czjjnlkf 2 5 Sanghoon Sanghoon NNP cord-018103-czjjnlkf 2 6 ; ; : cord-018103-czjjnlkf 2 7 Byun Byun NNP cord-018103-czjjnlkf 2 8 , , , cord-018103-czjjnlkf 2 9 Yanga Yanga NNP cord-018103-czjjnlkf 2 10 ; ; : cord-018103-czjjnlkf 2 11 Han Han NNP cord-018103-czjjnlkf 2 12 , , , cord-018103-czjjnlkf 3 1 Kyungsook Kyungsook NNP cord-018103-czjjnlkf 3 2 title title NN cord-018103-czjjnlkf 3 3 : : : cord-018103-czjjnlkf 3 4 Prediction prediction NN cord-018103-czjjnlkf 3 5 of of IN cord-018103-czjjnlkf 3 6 Ribosomal Ribosomal NNP cord-018103-czjjnlkf 3 7 -1 -1 NNP cord-018103-czjjnlkf 3 8 Frameshifts Frameshifts NNP cord-018103-czjjnlkf 3 9 in in IN cord-018103-czjjnlkf 3 10 the the DT cord-018103-czjjnlkf 3 11 Escherichia Escherichia NNP cord-018103-czjjnlkf 3 12 coli coli VBZ cord-018103-czjjnlkf 3 13 K12 K12 NNP cord-018103-czjjnlkf 3 14 Genome Genome NNP cord-018103-czjjnlkf 3 15 date date NN cord-018103-czjjnlkf 3 16 : : : cord-018103-czjjnlkf 3 17 2006 2006 CD cord-018103-czjjnlkf 3 18 journal journal NNP cord-018103-czjjnlkf 3 19 : : : cord-018103-czjjnlkf 4 1 Computational Computational NNP cord-018103-czjjnlkf 4 2 Intelligence Intelligence NNP cord-018103-czjjnlkf 4 3 and and CC cord-018103-czjjnlkf 4 4 Bioinformatics Bioinformatics NNP cord-018103-czjjnlkf 4 5 DOI DOI NNP cord-018103-czjjnlkf 4 6 : : : cord-018103-czjjnlkf 5 1 10.1007/11816102_65 10.1007/11816102_65 CD cord-018103-czjjnlkf 5 2 sha sha NNP cord-018103-czjjnlkf 5 3 : : : cord-018103-czjjnlkf 6 1 937b665c34abde05316890a5a9029c4052c9479e 937b665c34abde05316890a5a9029c4052c9479e CD cord-018103-czjjnlkf 6 2 doc_id doc_id CD cord-018103-czjjnlkf 6 3 : : : cord-018103-czjjnlkf 6 4 18103 18103 CD cord-018103-czjjnlkf 6 5 cord_uid cord_uid NNS cord-018103-czjjnlkf 6 6 : : : cord-018103-czjjnlkf 6 7 czjjnlkf czjjnlkf NNP cord-018103-czjjnlkf 6 8 Ribosomal Ribosomal NNP cord-018103-czjjnlkf 6 9 frameshifting frameshifte VBG cord-018103-czjjnlkf 6 10 at at IN cord-018103-czjjnlkf 6 11 a a DT cord-018103-czjjnlkf 6 12 particular particular JJ cord-018103-czjjnlkf 6 13 site site NN cord-018103-czjjnlkf 6 14 can can MD cord-018103-czjjnlkf 6 15 yield yield VB cord-018103-czjjnlkf 6 16 two two CD cord-018103-czjjnlkf 6 17 protein protein NN cord-018103-czjjnlkf 6 18 products product NNS cord-018103-czjjnlkf 6 19 from from IN cord-018103-czjjnlkf 6 20 one one CD cord-018103-czjjnlkf 6 21 coding code VBG cord-018103-czjjnlkf 6 22 sequence sequence NN cord-018103-czjjnlkf 6 23 or or CC cord-018103-czjjnlkf 6 24 one one CD cord-018103-czjjnlkf 6 25 protein protein NN cord-018103-czjjnlkf 6 26 product product NN cord-018103-czjjnlkf 6 27 from from IN cord-018103-czjjnlkf 6 28 two two CD cord-018103-czjjnlkf 6 29 overlapping overlap VBG cord-018103-czjjnlkf 6 30 open open JJ cord-018103-czjjnlkf 6 31 reading reading NN cord-018103-czjjnlkf 6 32 frames frame NNS cord-018103-czjjnlkf 6 33 . . . cord-018103-czjjnlkf 7 1 Many many JJ cord-018103-czjjnlkf 7 2 organisms organism NNS cord-018103-czjjnlkf 7 3 are be VBP cord-018103-czjjnlkf 7 4 known know VBN cord-018103-czjjnlkf 7 5 to to TO cord-018103-czjjnlkf 7 6 utilize utilize VB cord-018103-czjjnlkf 7 7 ribosomal ribosomal JJ cord-018103-czjjnlkf 7 8 frameshifting frameshifte VBG cord-018103-czjjnlkf 7 9 to to TO cord-018103-czjjnlkf 7 10 express express VB cord-018103-czjjnlkf 7 11 a a DT cord-018103-czjjnlkf 7 12 minority minority NN cord-018103-czjjnlkf 7 13 of of IN cord-018103-czjjnlkf 7 14 genes gene NNS cord-018103-czjjnlkf 7 15 . . . cord-018103-czjjnlkf 8 1 However however RB cord-018103-czjjnlkf 8 2 , , , cord-018103-czjjnlkf 8 3 finding find VBG cord-018103-czjjnlkf 8 4 ribosomal ribosomal JJ cord-018103-czjjnlkf 8 5 frameshift frameshift NN cord-018103-czjjnlkf 8 6 sites site NNS cord-018103-czjjnlkf 8 7 by by IN cord-018103-czjjnlkf 8 8 a a DT cord-018103-czjjnlkf 8 9 computational computational JJ cord-018103-czjjnlkf 8 10 method method NN cord-018103-czjjnlkf 8 11 is be VBZ cord-018103-czjjnlkf 8 12 difficult difficult JJ cord-018103-czjjnlkf 8 13 because because IN cord-018103-czjjnlkf 8 14 frameshift frameshift NN cord-018103-czjjnlkf 8 15 signals signal NNS cord-018103-czjjnlkf 8 16 are be VBP cord-018103-czjjnlkf 8 17 diverse diverse JJ cord-018103-czjjnlkf 8 18 and and CC cord-018103-czjjnlkf 8 19 dependent dependent JJ cord-018103-czjjnlkf 8 20 on on IN cord-018103-czjjnlkf 8 21 the the DT cord-018103-czjjnlkf 8 22 organisms organism NNS cord-018103-czjjnlkf 8 23 and and CC cord-018103-czjjnlkf 8 24 environments environment NNS cord-018103-czjjnlkf 8 25 . . . cord-018103-czjjnlkf 9 1 There there EX cord-018103-czjjnlkf 9 2 are be VBP cord-018103-czjjnlkf 9 3 few few JJ cord-018103-czjjnlkf 9 4 computer computer NN cord-018103-czjjnlkf 9 5 programs program NNS cord-018103-czjjnlkf 9 6 available available JJ cord-018103-czjjnlkf 9 7 for for IN cord-018103-czjjnlkf 9 8 public public JJ cord-018103-czjjnlkf 9 9 use use NN cord-018103-czjjnlkf 9 10 to to TO cord-018103-czjjnlkf 9 11 identify identify VB cord-018103-czjjnlkf 9 12 frameshift frameshift NN cord-018103-czjjnlkf 9 13 sites site NNS cord-018103-czjjnlkf 9 14 from from IN cord-018103-czjjnlkf 9 15 genomic genomic JJ cord-018103-czjjnlkf 9 16 sequences sequence NNS cord-018103-czjjnlkf 9 17 . . . cord-018103-czjjnlkf 10 1 We -PRON- PRP cord-018103-czjjnlkf 10 2 have have VBP cord-018103-czjjnlkf 10 3 developed develop VBN cord-018103-czjjnlkf 10 4 a a DT cord-018103-czjjnlkf 10 5 web web NN cord-018103-czjjnlkf 10 6 - - HYPH cord-018103-czjjnlkf 10 7 based base VBN cord-018103-czjjnlkf 10 8 application application NN cord-018103-czjjnlkf 10 9 program program NN cord-018103-czjjnlkf 10 10 called call VBN cord-018103-czjjnlkf 10 11 FSFinder2 FSFinder2 NNP cord-018103-czjjnlkf 10 12 for for IN cord-018103-czjjnlkf 10 13 predicting predict VBG cord-018103-czjjnlkf 10 14 frameshift frameshift NN cord-018103-czjjnlkf 10 15 sites site NNS cord-018103-czjjnlkf 10 16 of of IN cord-018103-czjjnlkf 10 17 general general JJ cord-018103-czjjnlkf 10 18 type type NN cord-018103-czjjnlkf 10 19 . . . cord-018103-czjjnlkf 11 1 We -PRON- PRP cord-018103-czjjnlkf 11 2 tested test VBD cord-018103-czjjnlkf 11 3 FSFinder2 FSFinder2 NNP cord-018103-czjjnlkf 11 4 on on IN cord-018103-czjjnlkf 11 5 the the DT cord-018103-czjjnlkf 11 6 Escherichia Escherichia NNP cord-018103-czjjnlkf 11 7 coli coli NNS cord-018103-czjjnlkf 11 8 K12 K12 NNP cord-018103-czjjnlkf 11 9 genome genome NN cord-018103-czjjnlkf 11 10 to to TO cord-018103-czjjnlkf 11 11 detect detect VB cord-018103-czjjnlkf 11 12 potential potential JJ cord-018103-czjjnlkf 11 13 -1 -1 NN cord-018103-czjjnlkf 11 14 frameshifting frameshifting JJ cord-018103-czjjnlkf 11 15 genes gene NNS cord-018103-czjjnlkf 11 16 . . . cord-018103-czjjnlkf 12 1 From from IN cord-018103-czjjnlkf 12 2 the the DT cord-018103-czjjnlkf 12 3 genome genome NN cord-018103-czjjnlkf 12 4 sequence sequence NN cord-018103-czjjnlkf 12 5 , , , cord-018103-czjjnlkf 12 6 we -PRON- PRP cord-018103-czjjnlkf 12 7 identified identify VBD cord-018103-czjjnlkf 12 8 18,401 18,401 CD cord-018103-czjjnlkf 12 9 frameshift frameshift NN cord-018103-czjjnlkf 12 10 sites site NNS cord-018103-czjjnlkf 12 11 following follow VBG cord-018103-czjjnlkf 12 12 the the DT cord-018103-czjjnlkf 12 13 X X NNP cord-018103-czjjnlkf 12 14 XXY XXY NNP cord-018103-czjjnlkf 12 15 YYZ YYZ NNP cord-018103-czjjnlkf 12 16 motif motif NN cord-018103-czjjnlkf 12 17 . . . cord-018103-czjjnlkf 13 1 11,530 11,530 CD cord-018103-czjjnlkf 13 2 frameshift frameshift NN cord-018103-czjjnlkf 13 3 sites site NNS cord-018103-czjjnlkf 13 4 out out IN cord-018103-czjjnlkf 13 5 of of IN cord-018103-czjjnlkf 13 6 the the DT cord-018103-czjjnlkf 13 7 18,401 18,401 CD cord-018103-czjjnlkf 13 8 sites site NNS cord-018103-czjjnlkf 13 9 include include VBP cord-018103-czjjnlkf 13 10 secondary secondary JJ cord-018103-czjjnlkf 13 11 structures structure NNS cord-018103-czjjnlkf 13 12 . . . cord-018103-czjjnlkf 14 1 Comparison comparison NN cord-018103-czjjnlkf 14 2 with with IN cord-018103-czjjnlkf 14 3 the the DT cord-018103-czjjnlkf 14 4 GenBank GenBank NNP cord-018103-czjjnlkf 14 5 annotation annotation NN cord-018103-czjjnlkf 14 6 produced produce VBD cord-018103-czjjnlkf 14 7 11 11 CD cord-018103-czjjnlkf 14 8 potential potential JJ cord-018103-czjjnlkf 14 9 frameshift frameshift NN cord-018103-czjjnlkf 14 10 sites site NNS cord-018103-czjjnlkf 14 11 , , , cord-018103-czjjnlkf 14 12 including include VBG cord-018103-czjjnlkf 14 13 3 3 CD cord-018103-czjjnlkf 14 14 known know VBN cord-018103-czjjnlkf 14 15 frameshift frameshift NN cord-018103-czjjnlkf 14 16 sites site NNS cord-018103-czjjnlkf 14 17 . . . cord-018103-czjjnlkf 15 1 The the DT cord-018103-czjjnlkf 15 2 program program NN cord-018103-czjjnlkf 15 3 is be VBZ cord-018103-czjjnlkf 15 4 useful useful JJ cord-018103-czjjnlkf 15 5 for for IN cord-018103-czjjnlkf 15 6 analyzing analyze VBG cord-018103-czjjnlkf 15 7 frameshifts frameshift NNS cord-018103-czjjnlkf 15 8 of of IN cord-018103-czjjnlkf 15 9 various various JJ cord-018103-czjjnlkf 15 10 types type NNS cord-018103-czjjnlkf 15 11 and and CC cord-018103-czjjnlkf 15 12 for for IN cord-018103-czjjnlkf 15 13 discovering discover VBG cord-018103-czjjnlkf 15 14 new new JJ cord-018103-czjjnlkf 15 15 genes gene NNS cord-018103-czjjnlkf 15 16 expressed express VBN cord-018103-czjjnlkf 15 17 by by IN cord-018103-czjjnlkf 15 18 frameshifts frameshifts NNP cord-018103-czjjnlkf 15 19 . . . cord-018103-czjjnlkf 16 1 Ribosomes ribosome NNS cord-018103-czjjnlkf 16 2 in in IN cord-018103-czjjnlkf 16 3 general general JJ cord-018103-czjjnlkf 16 4 terminate terminate VB cord-018103-czjjnlkf 16 5 translation translation NN cord-018103-czjjnlkf 16 6 at at IN cord-018103-czjjnlkf 16 7 three three CD cord-018103-czjjnlkf 16 8 kinds kind NNS cord-018103-czjjnlkf 16 9 of of IN cord-018103-czjjnlkf 16 10 stop stop NN cord-018103-czjjnlkf 16 11 codons codon NNS cord-018103-czjjnlkf 16 12 ( ( -LRB- cord-018103-czjjnlkf 16 13 UAG UAG NNP cord-018103-czjjnlkf 16 14 , , , cord-018103-czjjnlkf 16 15 UGA UGA NNP cord-018103-czjjnlkf 16 16 and and CC cord-018103-czjjnlkf 16 17 UAA UAA NNP cord-018103-czjjnlkf 16 18 ) ) -RRB- cord-018103-czjjnlkf 16 19 , , , cord-018103-czjjnlkf 16 20 but but CC cord-018103-czjjnlkf 16 21 some some DT cord-018103-czjjnlkf 16 22 ribosomes ribosome NNS cord-018103-czjjnlkf 16 23 continue continue VBP cord-018103-czjjnlkf 16 24 to to TO cord-018103-czjjnlkf 16 25 decode decode VB cord-018103-czjjnlkf 16 26 after after IN cord-018103-czjjnlkf 16 27 the the DT cord-018103-czjjnlkf 16 28 stop stop NN cord-018103-czjjnlkf 16 29 codons codon NNS cord-018103-czjjnlkf 16 30 . . . cord-018103-czjjnlkf 17 1 This this DT cord-018103-czjjnlkf 17 2 alternative alternative JJ cord-018103-czjjnlkf 17 3 translational translational JJ cord-018103-czjjnlkf 17 4 event event NN cord-018103-czjjnlkf 17 5 is be VBZ cord-018103-czjjnlkf 17 6 called call VBN cord-018103-czjjnlkf 17 7 ' ' `` cord-018103-czjjnlkf 17 8 recoding recoding NN cord-018103-czjjnlkf 17 9 ' ' '' cord-018103-czjjnlkf 17 10 . . . cord-018103-czjjnlkf 18 1 Recoding recoding NN cord-018103-czjjnlkf 18 2 events event NNS cord-018103-czjjnlkf 18 3 include include VBP cord-018103-czjjnlkf 18 4 frameshifting frameshifte VBG cord-018103-czjjnlkf 18 5 , , , cord-018103-czjjnlkf 18 6 read read VB cord-018103-czjjnlkf 18 7 - - HYPH cord-018103-czjjnlkf 18 8 through through NN cord-018103-czjjnlkf 18 9 and and CC cord-018103-czjjnlkf 18 10 bypassing bypass VBG cord-018103-czjjnlkf 18 11 [ [ -LRB- cord-018103-czjjnlkf 18 12 1 1 CD cord-018103-czjjnlkf 18 13 ] ] -RRB- cord-018103-czjjnlkf 18 14 [ [ -LRB- cord-018103-czjjnlkf 18 15 2 2 CD cord-018103-czjjnlkf 18 16 ] ] -RRB- cord-018103-czjjnlkf 18 17 [ [ -LRB- cord-018103-czjjnlkf 18 18 3 3 CD cord-018103-czjjnlkf 18 19 ] ] -RRB- cord-018103-czjjnlkf 18 20 . . . cord-018103-czjjnlkf 19 1 In in IN cord-018103-czjjnlkf 19 2 frameshifting frameshifte VBG cord-018103-czjjnlkf 19 3 , , , cord-018103-czjjnlkf 19 4 ribosomes ribosome NNS cord-018103-czjjnlkf 19 5 shift shift VBP cord-018103-czjjnlkf 19 6 reading reading NN cord-018103-czjjnlkf 19 7 frame frame NN cord-018103-czjjnlkf 19 8 by by IN cord-018103-czjjnlkf 19 9 one one CD cord-018103-czjjnlkf 19 10 or or CC cord-018103-czjjnlkf 19 11 more more JJR cord-018103-czjjnlkf 19 12 nucleotides nucleotide NNS cord-018103-czjjnlkf 19 13 at at IN cord-018103-czjjnlkf 19 14 a a DT cord-018103-czjjnlkf 19 15 specific specific JJ cord-018103-czjjnlkf 19 16 mRNA mrna NN cord-018103-czjjnlkf 19 17 signal signal NN cord-018103-czjjnlkf 19 18 between between IN cord-018103-czjjnlkf 19 19 overlapping overlap VBG cord-018103-czjjnlkf 19 20 genes gene NNS cord-018103-czjjnlkf 19 21 [ [ -LRB- cord-018103-czjjnlkf 19 22 4 4 CD cord-018103-czjjnlkf 19 23 ] ] -RRB- cord-018103-czjjnlkf 19 24 . . . cord-018103-czjjnlkf 20 1 Frameshifts frameshift NNS cord-018103-czjjnlkf 20 2 are be VBP cord-018103-czjjnlkf 20 3 classified classify VBN cord-018103-czjjnlkf 20 4 into into IN cord-018103-czjjnlkf 20 5 different different JJ cord-018103-czjjnlkf 20 6 types type NNS cord-018103-czjjnlkf 20 7 depending depend VBG cord-018103-czjjnlkf 20 8 on on IN cord-018103-czjjnlkf 20 9 the the DT cord-018103-czjjnlkf 20 10 number number NN cord-018103-czjjnlkf 20 11 of of IN cord-018103-czjjnlkf 20 12 nucleotides nucleotide NNS cord-018103-czjjnlkf 20 13 shifted shift VBN cord-018103-czjjnlkf 20 14 and and CC cord-018103-czjjnlkf 20 15 the the DT cord-018103-czjjnlkf 20 16 shifting shift VBG cord-018103-czjjnlkf 20 17 direction direction NN cord-018103-czjjnlkf 20 18 . . . cord-018103-czjjnlkf 21 1 The the DT cord-018103-czjjnlkf 21 2 most most RBS cord-018103-czjjnlkf 21 3 common common JJ cord-018103-czjjnlkf 21 4 type type NN cord-018103-czjjnlkf 21 5 is be VBZ cord-018103-czjjnlkf 21 6 a a DT cord-018103-czjjnlkf 21 7 -1 -1 NN cord-018103-czjjnlkf 21 8 frameshift frameshift NN cord-018103-czjjnlkf 21 9 , , , cord-018103-czjjnlkf 21 10 in in IN cord-018103-czjjnlkf 21 11 which which WDT cord-018103-czjjnlkf 21 12 the the DT cord-018103-czjjnlkf 21 13 ribosome ribosome NN cord-018103-czjjnlkf 21 14 slips slip VBZ cord-018103-czjjnlkf 21 15 a a DT cord-018103-czjjnlkf 21 16 single single JJ cord-018103-czjjnlkf 21 17 nucleotide nucleotide NN cord-018103-czjjnlkf 21 18 in in IN cord-018103-czjjnlkf 21 19 the the DT cord-018103-czjjnlkf 21 20 upstream upstream JJ cord-018103-czjjnlkf 21 21 direction direction NN cord-018103-czjjnlkf 21 22 . . . cord-018103-czjjnlkf 22 1 -1 -1 . cord-018103-czjjnlkf 23 1 frameshifting frameshifting NNP cord-018103-czjjnlkf 23 2 requires require VBZ cord-018103-czjjnlkf 23 3 a a DT cord-018103-czjjnlkf 23 4 frameshift frameshift NN cord-018103-czjjnlkf 23 5 cassette cassette NN cord-018103-czjjnlkf 23 6 that that WDT cord-018103-czjjnlkf 23 7 consists consist VBZ cord-018103-czjjnlkf 23 8 of of IN cord-018103-czjjnlkf 23 9 a a DT cord-018103-czjjnlkf 23 10 slippery slippery JJ cord-018103-czjjnlkf 23 11 site site NN cord-018103-czjjnlkf 23 12 , , , cord-018103-czjjnlkf 23 13 a a DT cord-018103-czjjnlkf 23 14 stimulatory stimulatory JJ cord-018103-czjjnlkf 23 15 RNA RNA NNP cord-018103-czjjnlkf 23 16 structure structure NN cord-018103-czjjnlkf 23 17 and and CC cord-018103-czjjnlkf 23 18 a a DT cord-018103-czjjnlkf 23 19 spacer spacer NN cord-018103-czjjnlkf 23 20 . . . cord-018103-czjjnlkf 24 1 +1 +1 NFP cord-018103-czjjnlkf 24 2 frameshifts frameshifts NNP cord-018103-czjjnlkf 24 3 are be VBP cord-018103-czjjnlkf 24 4 much much RB cord-018103-czjjnlkf 24 5 less less RBR cord-018103-czjjnlkf 24 6 common common JJ cord-018103-czjjnlkf 24 7 than than IN cord-018103-czjjnlkf 24 8 -1 -1 NNP cord-018103-czjjnlkf 24 9 frameshifts frameshift NNS cord-018103-czjjnlkf 24 10 , , , cord-018103-czjjnlkf 24 11 but but CC cord-018103-czjjnlkf 24 12 have have VBP cord-018103-czjjnlkf 24 13 been be VBN cord-018103-czjjnlkf 24 14 observed observe VBN cord-018103-czjjnlkf 24 15 in in IN cord-018103-czjjnlkf 24 16 diverse diverse JJ cord-018103-czjjnlkf 24 17 organisms organism NNS cord-018103-czjjnlkf 24 18 [ [ -LRB- cord-018103-czjjnlkf 24 19 1 1 CD cord-018103-czjjnlkf 24 20 ] ] -RRB- cord-018103-czjjnlkf 24 21 . . . cord-018103-czjjnlkf 25 1 No no DT cord-018103-czjjnlkf 25 2 program program NN cord-018103-czjjnlkf 25 3 exists exist VBZ cord-018103-czjjnlkf 25 4 to to TO cord-018103-czjjnlkf 25 5 predict predict VB cord-018103-czjjnlkf 25 6 general general JJ cord-018103-czjjnlkf 25 7 types type NNS cord-018103-czjjnlkf 25 8 of of IN cord-018103-czjjnlkf 25 9 frameshift frameshift NN cord-018103-czjjnlkf 25 10 . . . cord-018103-czjjnlkf 26 1 In in IN cord-018103-czjjnlkf 26 2 addition addition NN cord-018103-czjjnlkf 26 3 , , , cord-018103-czjjnlkf 26 4 existing exist VBG cord-018103-czjjnlkf 26 5 computational computational JJ cord-018103-czjjnlkf 26 6 models model NNS cord-018103-czjjnlkf 26 7 predict predict VBP cord-018103-czjjnlkf 26 8 too too RB cord-018103-czjjnlkf 26 9 many many JJ cord-018103-czjjnlkf 26 10 false false JJ cord-018103-czjjnlkf 26 11 positives positive NNS cord-018103-czjjnlkf 26 12 . . . cord-018103-czjjnlkf 27 1 In in IN cord-018103-czjjnlkf 27 2 previous previous JJ cord-018103-czjjnlkf 27 3 work work NN cord-018103-czjjnlkf 27 4 we -PRON- PRP cord-018103-czjjnlkf 27 5 developed develop VBD cord-018103-czjjnlkf 27 6 a a DT cord-018103-czjjnlkf 27 7 program program NN cord-018103-czjjnlkf 27 8 called call VBN cord-018103-czjjnlkf 27 9 FSFinder FSFinder NNP cord-018103-czjjnlkf 28 1 ( ( -LRB- cord-018103-czjjnlkf 28 2 Frameshift Frameshift NNP cord-018103-czjjnlkf 28 3 Signal Signal NNP cord-018103-czjjnlkf 28 4 Finder Finder NNP cord-018103-czjjnlkf 28 5 ) ) -RRB- cord-018103-czjjnlkf 28 6 for for IN cord-018103-czjjnlkf 28 7 predicting predict VBG cord-018103-czjjnlkf 28 8 -1 -1 NN cord-018103-czjjnlkf 28 9 and and CC cord-018103-czjjnlkf 28 10 +1 +1 HYPH cord-018103-czjjnlkf 28 11 frameshift frameshift NN cord-018103-czjjnlkf 28 12 sites site NNS cord-018103-czjjnlkf 28 13 [ [ -LRB- cord-018103-czjjnlkf 28 14 5 5 CD cord-018103-czjjnlkf 28 15 ] ] -RRB- cord-018103-czjjnlkf 28 16 . . . cord-018103-czjjnlkf 29 1 That that DT cord-018103-czjjnlkf 29 2 program program NN cord-018103-czjjnlkf 29 3 is be VBZ cord-018103-czjjnlkf 29 4 written write VBN cord-018103-czjjnlkf 29 5 in in IN cord-018103-czjjnlkf 29 6 Microsoft Microsoft NNP cord-018103-czjjnlkf 29 7 C C NNP cord-018103-czjjnlkf 29 8 # # NN cord-018103-czjjnlkf 29 9 and and CC cord-018103-czjjnlkf 29 10 is be VBZ cord-018103-czjjnlkf 29 11 executable executable JJ cord-018103-czjjnlkf 29 12 on on IN cord-018103-czjjnlkf 29 13 Windows Windows NNP cord-018103-czjjnlkf 29 14 systems system NNS cord-018103-czjjnlkf 29 15 only only RB cord-018103-czjjnlkf 29 16 . . . cord-018103-czjjnlkf 30 1 To to TO cord-018103-czjjnlkf 30 2 remove remove VB cord-018103-czjjnlkf 30 3 these these DT cord-018103-czjjnlkf 30 4 limitations limitation NNS cord-018103-czjjnlkf 30 5 and and CC cord-018103-czjjnlkf 30 6 to to TO cord-018103-czjjnlkf 30 7 handle handle VB cord-018103-czjjnlkf 30 8 frameshifts frameshift NNS cord-018103-czjjnlkf 30 9 of of IN cord-018103-czjjnlkf 30 10 general general JJ cord-018103-czjjnlkf 30 11 type type NN cord-018103-czjjnlkf 30 12 , , , cord-018103-czjjnlkf 30 13 we -PRON- PRP cord-018103-czjjnlkf 30 14 developed develop VBD cord-018103-czjjnlkf 30 15 a a DT cord-018103-czjjnlkf 30 16 new new JJ cord-018103-czjjnlkf 30 17 web web NN cord-018103-czjjnlkf 30 18 - - HYPH cord-018103-czjjnlkf 30 19 based base VBN cord-018103-czjjnlkf 30 20 application application NN cord-018103-czjjnlkf 30 21 called call VBN cord-018103-czjjnlkf 30 22 FSFinder2 FSFinder2 NNP cord-018103-czjjnlkf 30 23 . . . cord-018103-czjjnlkf 31 1 Users user NNS cord-018103-czjjnlkf 31 2 can can MD cord-018103-czjjnlkf 31 3 predict predict VB cord-018103-czjjnlkf 31 4 frameshift frameshift NN cord-018103-czjjnlkf 31 5 sites site NNS cord-018103-czjjnlkf 31 6 of of IN cord-018103-czjjnlkf 31 7 any any DT cord-018103-czjjnlkf 31 8 type type NN cord-018103-czjjnlkf 31 9 online online RB cord-018103-czjjnlkf 31 10 from from IN cord-018103-czjjnlkf 31 11 any any DT cord-018103-czjjnlkf 31 12 web web NN cord-018103-czjjnlkf 31 13 browser browser NN cord-018103-czjjnlkf 31 14 and and CC cord-018103-czjjnlkf 31 15 operating operating NN cord-018103-czjjnlkf 31 16 system system NN cord-018103-czjjnlkf 31 17 . . . cord-018103-czjjnlkf 32 1 In in IN cord-018103-czjjnlkf 32 2 previous previous JJ cord-018103-czjjnlkf 32 3 experimental experimental JJ cord-018103-czjjnlkf 32 4 results result NNS cord-018103-czjjnlkf 32 5 of of IN cord-018103-czjjnlkf 32 6 testing test VBG cord-018103-czjjnlkf 32 7 FSFinder2 FSFinder2 NNP cord-018103-czjjnlkf 32 8 on on IN cord-018103-czjjnlkf 32 9 ~190 ~190 NFP cord-018103-czjjnlkf 32 10 genomic genomic JJ cord-018103-czjjnlkf 32 11 and and CC cord-018103-czjjnlkf 32 12 partial partial JJ cord-018103-czjjnlkf 32 13 DNA dna NN cord-018103-czjjnlkf 32 14 sequences sequence NNS cord-018103-czjjnlkf 32 15 showed show VBD cord-018103-czjjnlkf 32 16 that that IN cord-018103-czjjnlkf 32 17 it -PRON- PRP cord-018103-czjjnlkf 32 18 predicted predict VBD cord-018103-czjjnlkf 32 19 frameshift frameshift NN cord-018103-czjjnlkf 32 20 sites site NNS cord-018103-czjjnlkf 32 21 efficiently efficiently RB cord-018103-czjjnlkf 32 22 and and CC cord-018103-czjjnlkf 32 23 with with IN cord-018103-czjjnlkf 32 24 greater great JJR cord-018103-czjjnlkf 32 25 sensitivity sensitivity NN cord-018103-czjjnlkf 32 26 and and CC cord-018103-czjjnlkf 32 27 specificity specificity NN cord-018103-czjjnlkf 32 28 than than IN cord-018103-czjjnlkf 32 29 other other JJ cord-018103-czjjnlkf 32 30 programs program NNS cord-018103-czjjnlkf 32 31 , , , cord-018103-czjjnlkf 32 32 because because IN cord-018103-czjjnlkf 32 33 it -PRON- PRP cord-018103-czjjnlkf 32 34 focused focus VBD cord-018103-czjjnlkf 32 35 on on IN cord-018103-czjjnlkf 32 36 the the DT cord-018103-czjjnlkf 32 37 overlapping overlap VBG cord-018103-czjjnlkf 32 38 regions region NNS cord-018103-czjjnlkf 32 39 of of IN cord-018103-czjjnlkf 32 40 ORFs orf NNS cord-018103-czjjnlkf 32 41 and and CC cord-018103-czjjnlkf 32 42 prioritized prioritize VBN cord-018103-czjjnlkf 32 43 candidate candidate NN cord-018103-czjjnlkf 32 44 signals signal NNS cord-018103-czjjnlkf 32 45 ( ( -LRB- cord-018103-czjjnlkf 32 46 For for IN cord-018103-czjjnlkf 32 47 -1 -1 NNP cord-018103-czjjnlkf 32 48 frameshifts frameshifts NNP cord-018103-czjjnlkf 32 49 , , , cord-018103-czjjnlkf 32 50 sensitivity sensitivity NN cord-018103-czjjnlkf 32 51 was be VBD cord-018103-czjjnlkf 32 52 0.88 0.88 CD cord-018103-czjjnlkf 32 53 and and CC cord-018103-czjjnlkf 32 54 specificity specificity NN cord-018103-czjjnlkf 32 55 0.97 0.97 CD cord-018103-czjjnlkf 32 56 ; ; : cord-018103-czjjnlkf 32 57 for for IN cord-018103-czjjnlkf 32 58 +1 +1 LS cord-018103-czjjnlkf 32 59 frameshifts frameshifts NNP cord-018103-czjjnlkf 32 60 , , , cord-018103-czjjnlkf 32 61 sensitivity sensitivity NN cord-018103-czjjnlkf 32 62 was be VBD cord-018103-czjjnlkf 32 63 0.91 0.91 CD cord-018103-czjjnlkf 32 64 and and CC cord-018103-czjjnlkf 32 65 specificity specificity NN cord-018103-czjjnlkf 32 66 0.94 0.94 CD cord-018103-czjjnlkf 32 67 ) ) -RRB- cord-018103-czjjnlkf 33 1 [ [ -LRB- cord-018103-czjjnlkf 33 2 5 5 CD cord-018103-czjjnlkf 33 3 ] ] -RRB- cord-018103-czjjnlkf 33 4 [ [ -LRB- cord-018103-czjjnlkf 33 5 6 6 CD cord-018103-czjjnlkf 33 6 ] ] -RRB- cord-018103-czjjnlkf 33 7 [ [ -LRB- cord-018103-czjjnlkf 33 8 7 7 CD cord-018103-czjjnlkf 33 9 ] ] -RRB- cord-018103-czjjnlkf 33 10 . . . cord-018103-czjjnlkf 34 1 Using use VBG cord-018103-czjjnlkf 34 2 the the DT cord-018103-czjjnlkf 34 3 web web NN cord-018103-czjjnlkf 34 4 service service NN cord-018103-czjjnlkf 34 5 of of IN cord-018103-czjjnlkf 34 6 the the DT cord-018103-czjjnlkf 34 7 FSFinder2 FSFinder2 NNP cord-018103-czjjnlkf 34 8 , , , cord-018103-czjjnlkf 34 9 we -PRON- PRP cord-018103-czjjnlkf 34 10 analyzed analyze VBD cord-018103-czjjnlkf 34 11 the the DT cord-018103-czjjnlkf 34 12 Escherichia Escherichia NNP cord-018103-czjjnlkf 34 13 coli coli NNS cord-018103-czjjnlkf 34 14 ( ( -LRB- cord-018103-czjjnlkf 34 15 E. E. NNP cord-018103-czjjnlkf 34 16 coli coli NNS cord-018103-czjjnlkf 34 17 ) ) -RRB- cord-018103-czjjnlkf 35 1 K12 K12 NNP cord-018103-czjjnlkf 35 2 genome genome NN cord-018103-czjjnlkf 35 3 sequence sequence NN cord-018103-czjjnlkf 35 4 to to TO cord-018103-czjjnlkf 35 5 find find VB cord-018103-czjjnlkf 35 6 the the DT cord-018103-czjjnlkf 35 7 -1 -1 NN cord-018103-czjjnlkf 35 8 frameshifting frameshifting JJ cord-018103-czjjnlkf 35 9 genes gene NNS cord-018103-czjjnlkf 35 10 with with IN cord-018103-czjjnlkf 35 11 high high JJ cord-018103-czjjnlkf 35 12 probability probability NN cord-018103-czjjnlkf 35 13 . . . cord-018103-czjjnlkf 36 1 From from IN cord-018103-czjjnlkf 36 2 the the DT cord-018103-czjjnlkf 36 3 E. E. NNP cord-018103-czjjnlkf 36 4 coli coli VBZ cord-018103-czjjnlkf 36 5 K12 K12 NNP cord-018103-czjjnlkf 36 6 genome genome NN cord-018103-czjjnlkf 36 7 sequence sequence NN cord-018103-czjjnlkf 36 8 , , , cord-018103-czjjnlkf 36 9 we -PRON- PRP cord-018103-czjjnlkf 36 10 found find VBD cord-018103-czjjnlkf 36 11 18,401 18,401 CD cord-018103-czjjnlkf 36 12 frameshift frameshift NN cord-018103-czjjnlkf 36 13 sites site NNS cord-018103-czjjnlkf 36 14 after after IN cord-018103-czjjnlkf 36 15 the the DT cord-018103-czjjnlkf 36 16 X x NN cord-018103-czjjnlkf 36 17 XXY XXY NNP cord-018103-czjjnlkf 36 18 YYZ YYZ NNP cord-018103-czjjnlkf 36 19 motif motif NN cord-018103-czjjnlkf 36 20 . . . cord-018103-czjjnlkf 37 1 Among among IN cord-018103-czjjnlkf 37 2 these these DT cord-018103-czjjnlkf 37 3 sequences sequence NNS cord-018103-czjjnlkf 37 4 , , , cord-018103-czjjnlkf 37 5 11,530 11,530 CD cord-018103-czjjnlkf 37 6 frameshift frameshift NN cord-018103-czjjnlkf 37 7 sites site NNS cord-018103-czjjnlkf 37 8 included include VBD cord-018103-czjjnlkf 37 9 secondary secondary JJ cord-018103-czjjnlkf 37 10 structure structure NN cord-018103-czjjnlkf 37 11 such such JJ cord-018103-czjjnlkf 37 12 as as IN cord-018103-czjjnlkf 37 13 pseudoknots pseudoknot NNS cord-018103-czjjnlkf 37 14 or or CC cord-018103-czjjnlkf 37 15 stem stem NN cord-018103-czjjnlkf 37 16 - - HYPH cord-018103-czjjnlkf 37 17 loops loop NNS cord-018103-czjjnlkf 37 18 . . . cord-018103-czjjnlkf 38 1 Using use VBG cord-018103-czjjnlkf 38 2 the the DT cord-018103-czjjnlkf 38 3 GenBank GenBank NNP cord-018103-czjjnlkf 38 4 description description NN cord-018103-czjjnlkf 38 5 we -PRON- PRP cord-018103-czjjnlkf 38 6 found find VBD cord-018103-czjjnlkf 38 7 312 312 CD cord-018103-czjjnlkf 38 8 overlapping overlap VBG cord-018103-czjjnlkf 38 9 regions region NNS cord-018103-czjjnlkf 38 10 of of IN cord-018103-czjjnlkf 38 11 two two CD cord-018103-czjjnlkf 38 12 genes gene NNS cord-018103-czjjnlkf 38 13 with with IN cord-018103-czjjnlkf 38 14 more more JJR cord-018103-czjjnlkf 38 15 than than IN cord-018103-czjjnlkf 38 16 1 1 CD cord-018103-czjjnlkf 38 17 base base NN cord-018103-czjjnlkf 38 18 . . . cord-018103-czjjnlkf 39 1 Using use VBG cord-018103-czjjnlkf 39 2 FSFinder FSFinder NNP cord-018103-czjjnlkf 39 3 we -PRON- PRP cord-018103-czjjnlkf 39 4 found find VBD cord-018103-czjjnlkf 39 5 309 309 CD cord-018103-czjjnlkf 39 6 overlapping overlap VBG cord-018103-czjjnlkf 39 7 regions region NNS cord-018103-czjjnlkf 39 8 with with IN cord-018103-czjjnlkf 39 9 more more JJR cord-018103-czjjnlkf 39 10 than than IN cord-018103-czjjnlkf 39 11 30 30 CD cord-018103-czjjnlkf 39 12 bases basis NNS cord-018103-czjjnlkf 39 13 . . . cord-018103-czjjnlkf 40 1 After after IN cord-018103-czjjnlkf 40 2 removing remove VBG cord-018103-czjjnlkf 40 3 redundant redundant JJ cord-018103-czjjnlkf 40 4 ones one NNS cord-018103-czjjnlkf 40 5 , , , cord-018103-czjjnlkf 40 6 we -PRON- PRP cord-018103-czjjnlkf 40 7 obtained obtain VBD cord-018103-czjjnlkf 40 8 195 195 CD cord-018103-czjjnlkf 40 9 overlapping overlap VBG cord-018103-czjjnlkf 40 10 regions region NNS cord-018103-czjjnlkf 40 11 and and CC cord-018103-czjjnlkf 40 12 found find VBD cord-018103-czjjnlkf 40 13 66 66 CD cord-018103-czjjnlkf 40 14 potential potential JJ cord-018103-czjjnlkf 40 15 frameshift frameshift NN cord-018103-czjjnlkf 40 16 sites site NNS cord-018103-czjjnlkf 40 17 in in IN cord-018103-czjjnlkf 40 18 the the DT cord-018103-czjjnlkf 40 19 195 195 CD cord-018103-czjjnlkf 40 20 overlapping overlap VBG cord-018103-czjjnlkf 40 21 regions region NNS cord-018103-czjjnlkf 40 22 . . . cord-018103-czjjnlkf 41 1 Among among IN cord-018103-czjjnlkf 41 2 these these DT cord-018103-czjjnlkf 41 3 sites site NNS cord-018103-czjjnlkf 41 4 , , , cord-018103-czjjnlkf 41 5 11 11 CD cord-018103-czjjnlkf 41 6 sites site NNS cord-018103-czjjnlkf 41 7 including include VBG cord-018103-czjjnlkf 41 8 3 3 CD cord-018103-czjjnlkf 41 9 known know VBN cord-018103-czjjnlkf 41 10 frameshift frameshift NN cord-018103-czjjnlkf 41 11 sites site NNS cord-018103-czjjnlkf 41 12 were be VBD cord-018103-czjjnlkf 41 13 considered consider VBN cord-018103-czjjnlkf 41 14 significant significant JJ cord-018103-czjjnlkf 41 15 based base VBN cord-018103-czjjnlkf 41 16 on on IN cord-018103-czjjnlkf 41 17 the the DT cord-018103-czjjnlkf 41 18 gene gene NN cord-018103-czjjnlkf 41 19 length length NN cord-018103-czjjnlkf 41 20 , , , cord-018103-czjjnlkf 41 21 shape shape NN cord-018103-czjjnlkf 41 22 and and CC cord-018103-czjjnlkf 41 23 the the DT cord-018103-czjjnlkf 41 24 length length NN cord-018103-czjjnlkf 41 25 of of IN cord-018103-czjjnlkf 41 26 overlapping overlap VBG cord-018103-czjjnlkf 41 27 region region NN cord-018103-czjjnlkf 41 28 . . . cord-018103-czjjnlkf 42 1 We -PRON- PRP cord-018103-czjjnlkf 42 2 believe believe VBP cord-018103-czjjnlkf 42 3 that that IN cord-018103-czjjnlkf 42 4 at at RB cord-018103-czjjnlkf 42 5 least least JJS cord-018103-czjjnlkf 42 6 4 4 CD cord-018103-czjjnlkf 42 7 new new JJ cord-018103-czjjnlkf 42 8 frameshift frameshift NN cord-018103-czjjnlkf 42 9 sites site NNS cord-018103-czjjnlkf 42 10 are be VBP cord-018103-czjjnlkf 42 11 highly highly RB cord-018103-czjjnlkf 42 12 likely likely JJ cord-018103-czjjnlkf 42 13 to to TO cord-018103-czjjnlkf 42 14 be be VB cord-018103-czjjnlkf 42 15 frameshift frameshift NN cord-018103-czjjnlkf 42 16 sites site NNS cord-018103-czjjnlkf 42 17 . . . cord-018103-czjjnlkf 43 1 The the DT cord-018103-czjjnlkf 43 2 cassettes cassette NNS cord-018103-czjjnlkf 43 3 of of IN cord-018103-czjjnlkf 43 4 -1 -1 CD cord-018103-czjjnlkf 43 5 frameshift frameshift NN cord-018103-czjjnlkf 43 6 consist consist NN cord-018103-czjjnlkf 43 7 of of IN cord-018103-czjjnlkf 43 8 three three CD cord-018103-czjjnlkf 43 9 parts part NNS cord-018103-czjjnlkf 43 10 : : : cord-018103-czjjnlkf 43 11 slippery slippery JJ cord-018103-czjjnlkf 43 12 site site NN cord-018103-czjjnlkf 43 13 , , , cord-018103-czjjnlkf 43 14 spacer spacer NN cord-018103-czjjnlkf 43 15 and and CC cord-018103-czjjnlkf 43 16 secondary secondary JJ cord-018103-czjjnlkf 43 17 structure structure NN cord-018103-czjjnlkf 43 18 . . . cord-018103-czjjnlkf 44 1 The the DT cord-018103-czjjnlkf 44 2 slippery slippery JJ cord-018103-czjjnlkf 44 3 site site NN cord-018103-czjjnlkf 44 4 is be VBZ cord-018103-czjjnlkf 44 5 usually usually RB cord-018103-czjjnlkf 44 6 a a DT cord-018103-czjjnlkf 44 7 heptameric heptameric JJ cord-018103-czjjnlkf 44 8 sequence sequence NN cord-018103-czjjnlkf 44 9 in in IN cord-018103-czjjnlkf 44 10 the the DT cord-018103-czjjnlkf 44 11 form form NN cord-018103-czjjnlkf 44 12 X x NN cord-018103-czjjnlkf 44 13 XXY XXY NNP cord-018103-czjjnlkf 44 14 YYZ YYZ NNP cord-018103-czjjnlkf 44 15 ( ( -LRB- cord-018103-czjjnlkf 44 16 in in IN cord-018103-czjjnlkf 44 17 the the DT cord-018103-czjjnlkf 44 18 incoming incoming JJ cord-018103-czjjnlkf 44 19 0-frame 0-frame CD cord-018103-czjjnlkf 44 20 ) ) -RRB- cord-018103-czjjnlkf 44 21 , , , cord-018103-czjjnlkf 44 22 where where WRB cord-018103-czjjnlkf 44 23 X X NNP cord-018103-czjjnlkf 44 24 , , , cord-018103-czjjnlkf 44 25 Y Y NNP cord-018103-czjjnlkf 44 26 and and CC cord-018103-czjjnlkf 44 27 Z z NN cord-018103-czjjnlkf 44 28 can can MD cord-018103-czjjnlkf 44 29 be be VB cord-018103-czjjnlkf 44 30 same same JJ cord-018103-czjjnlkf 44 31 nucleotides nucleotide NNS cord-018103-czjjnlkf 44 32 [ [ -LRB- cord-018103-czjjnlkf 44 33 5 5 CD cord-018103-czjjnlkf 44 34 ] ] -RRB- cord-018103-czjjnlkf 44 35 [ [ -LRB- cord-018103-czjjnlkf 44 36 6 6 CD cord-018103-czjjnlkf 44 37 ] ] -RRB- cord-018103-czjjnlkf 44 38 [ [ -LRB- cord-018103-czjjnlkf 44 39 7 7 CD cord-018103-czjjnlkf 44 40 ] ] -RRB- cord-018103-czjjnlkf 44 41 . . . cord-018103-czjjnlkf 45 1 The the DT cord-018103-czjjnlkf 45 2 spacer spacer NN cord-018103-czjjnlkf 45 3 is be VBZ cord-018103-czjjnlkf 45 4 a a DT cord-018103-czjjnlkf 45 5 short short JJ cord-018103-czjjnlkf 45 6 sequence sequence NN cord-018103-czjjnlkf 45 7 of of IN cord-018103-czjjnlkf 45 8 5 5 CD cord-018103-czjjnlkf 45 9 to to TO cord-018103-czjjnlkf 45 10 11 11 CD cord-018103-czjjnlkf 45 11 nucleotides nucleotide NNS cord-018103-czjjnlkf 45 12 separating separate VBG cord-018103-czjjnlkf 45 13 slippery slippery JJ cord-018103-czjjnlkf 45 14 site site NN cord-018103-czjjnlkf 45 15 and and CC cord-018103-czjjnlkf 45 16 the the DT cord-018103-czjjnlkf 45 17 downstream downstream JJ cord-018103-czjjnlkf 45 18 secondary secondary JJ cord-018103-czjjnlkf 45 19 structure structure NN cord-018103-czjjnlkf 45 20 . . . cord-018103-czjjnlkf 46 1 The the DT cord-018103-czjjnlkf 46 2 downstream downstream JJ cord-018103-czjjnlkf 46 3 structure structure NN cord-018103-czjjnlkf 46 4 is be VBZ cord-018103-czjjnlkf 46 5 usually usually RB cord-018103-czjjnlkf 46 6 a a DT cord-018103-czjjnlkf 46 7 pseudoknot pseudoknot NN cord-018103-czjjnlkf 46 8 or or CC cord-018103-czjjnlkf 46 9 simple simple JJ cord-018103-czjjnlkf 46 10 stem stem NN cord-018103-czjjnlkf 46 11 - - HYPH cord-018103-czjjnlkf 46 12 loop loop NN cord-018103-czjjnlkf 46 13 , , , cord-018103-czjjnlkf 46 14 as as IN cord-018103-czjjnlkf 46 15 shown show VBN cord-018103-czjjnlkf 46 16 in in IN cord-018103-czjjnlkf 46 17 Fig Fig NNP cord-018103-czjjnlkf 46 18 . . . cord-018103-czjjnlkf 47 1 1 1 LS cord-018103-czjjnlkf 47 2 . . . cord-018103-czjjnlkf 48 1 For for IN cord-018103-czjjnlkf 48 2 analyzing analyze VBG cord-018103-czjjnlkf 48 3 frameshift frameshift NN cord-018103-czjjnlkf 48 4 sites site NNS cord-018103-czjjnlkf 48 5 in in IN cord-018103-czjjnlkf 48 6 the the DT cord-018103-czjjnlkf 48 7 E. E. NNP cord-018103-czjjnlkf 48 8 coli coli NN cord-018103-czjjnlkf 48 9 genome genome NN cord-018103-czjjnlkf 48 10 sequence sequence NN cord-018103-czjjnlkf 48 11 , , , cord-018103-czjjnlkf 48 12 we -PRON- PRP cord-018103-czjjnlkf 48 13 detected detect VBD cord-018103-czjjnlkf 48 14 heptameric heptameric JJ cord-018103-czjjnlkf 48 15 sequence sequence NN cord-018103-czjjnlkf 48 16 with with IN cord-018103-czjjnlkf 48 17 a a DT cord-018103-czjjnlkf 48 18 secondary secondary JJ cord-018103-czjjnlkf 48 19 structure structure NN cord-018103-czjjnlkf 48 20 . . . cord-018103-czjjnlkf 49 1 In in IN cord-018103-czjjnlkf 49 2 previous previous JJ cord-018103-czjjnlkf 49 3 work work NN cord-018103-czjjnlkf 49 4 by by IN cord-018103-czjjnlkf 49 5 others other NNS cord-018103-czjjnlkf 49 6 [ [ -LRB- cord-018103-czjjnlkf 49 7 5 5 CD cord-018103-czjjnlkf 49 8 ] ] -RRB- cord-018103-czjjnlkf 49 9 [ [ -LRB- cord-018103-czjjnlkf 49 10 6 6 CD cord-018103-czjjnlkf 49 11 ] ] -RRB- cord-018103-czjjnlkf 49 12 [ [ -LRB- cord-018103-czjjnlkf 49 13 7 7 CD cord-018103-czjjnlkf 49 14 ] ] -RRB- cord-018103-czjjnlkf 49 15 , , , cord-018103-czjjnlkf 49 16 frameshift frameshift NN cord-018103-czjjnlkf 49 17 sites site NNS cord-018103-czjjnlkf 49 18 have have VBP cord-018103-czjjnlkf 49 19 two two CD cord-018103-czjjnlkf 49 20 constraints constraint NNS cord-018103-czjjnlkf 49 21 . . . cord-018103-czjjnlkf 50 1 In in IN cord-018103-czjjnlkf 50 2 slippery slippery JJ cord-018103-czjjnlkf 50 3 site site NN cord-018103-czjjnlkf 50 4 X x NN cord-018103-czjjnlkf 50 5 XXY XXY NNP cord-018103-czjjnlkf 50 6 YYZ YYZ NNP cord-018103-czjjnlkf 50 7 , , , cord-018103-czjjnlkf 50 8 X X NNP cord-018103-czjjnlkf 50 9 is be VBZ cord-018103-czjjnlkf 50 10 any any DT cord-018103-czjjnlkf 50 11 nucleotide nucleotide NN cord-018103-czjjnlkf 50 12 , , , cord-018103-czjjnlkf 50 13 Y Y NNP cord-018103-czjjnlkf 50 14 is be VBZ cord-018103-czjjnlkf 50 15 A a NN cord-018103-czjjnlkf 50 16 or or CC cord-018103-czjjnlkf 50 17 U u NN cord-018103-czjjnlkf 50 18 , , , cord-018103-czjjnlkf 50 19 and and CC cord-018103-czjjnlkf 50 20 Z z NN cord-018103-czjjnlkf 50 21 is be VBZ cord-018103-czjjnlkf 50 22 either either CC cord-018103-czjjnlkf 50 23 A A NNP cord-018103-czjjnlkf 50 24 , , , cord-018103-czjjnlkf 50 25 U U NNP cord-018103-czjjnlkf 50 26 or or CC cord-018103-czjjnlkf 50 27 C. C. NNP cord-018103-czjjnlkf 51 1 However however RB cord-018103-czjjnlkf 51 2 , , , cord-018103-czjjnlkf 51 3 in in IN cord-018103-czjjnlkf 51 4 our -PRON- PRP$ cord-018103-czjjnlkf 51 5 work work NN cord-018103-czjjnlkf 51 6 , , , cord-018103-czjjnlkf 51 7 any any DT cord-018103-czjjnlkf 51 8 kind kind NN cord-018103-czjjnlkf 51 9 of of IN cord-018103-czjjnlkf 51 10 nucleotide nucleotide JJ cord-018103-czjjnlkf 51 11 with with IN cord-018103-czjjnlkf 51 12 secondary secondary JJ cord-018103-czjjnlkf 51 13 structure structure NN cord-018103-czjjnlkf 51 14 can can MD cord-018103-czjjnlkf 51 15 be be VB cord-018103-czjjnlkf 51 16 located locate VBN cord-018103-czjjnlkf 51 17 in in IN cord-018103-czjjnlkf 51 18 the the DT cord-018103-czjjnlkf 51 19 slippery slippery JJ cord-018103-czjjnlkf 51 20 sequence sequence NN cord-018103-czjjnlkf 51 21 . . . cord-018103-czjjnlkf 52 1 Fig Fig NNP cord-018103-czjjnlkf 52 2 . . NNP cord-018103-czjjnlkf 52 3 2 2 CD cord-018103-czjjnlkf 52 4 shows show VBZ cord-018103-czjjnlkf 52 5 the the DT cord-018103-czjjnlkf 52 6 parameters parameter NNS cord-018103-czjjnlkf 52 7 for for IN cord-018103-czjjnlkf 52 8 the the DT cord-018103-czjjnlkf 52 9 FSFinder FSFinder NNP cord-018103-czjjnlkf 52 10 web web NN cord-018103-czjjnlkf 52 11 service service NN cord-018103-czjjnlkf 52 12 . . . cord-018103-czjjnlkf 53 1 The the DT cord-018103-czjjnlkf 53 2 web web NN cord-018103-czjjnlkf 53 3 service service NN cord-018103-czjjnlkf 53 4 and and CC cord-018103-czjjnlkf 53 5 web web NN cord-018103-czjjnlkf 53 6 application application NN cord-018103-czjjnlkf 53 7 of of IN cord-018103-czjjnlkf 53 8 FSFinder2 FSFinder2 NNP cord-018103-czjjnlkf 53 9 were be VBD cord-018103-czjjnlkf 53 10 implemented implement VBN cord-018103-czjjnlkf 53 11 using use VBG cord-018103-czjjnlkf 53 12 XML xml NN cord-018103-czjjnlkf 53 13 , , , cord-018103-czjjnlkf 53 14 XSLT xslt NN cord-018103-czjjnlkf 53 15 and and CC cord-018103-czjjnlkf 53 16 JavaScript JavaScript NNP cord-018103-czjjnlkf 53 17 . . . cord-018103-czjjnlkf 54 1 If if IN cord-018103-czjjnlkf 54 2 the the DT cord-018103-czjjnlkf 54 3 user user NN cord-018103-czjjnlkf 54 4 sends send VBZ cord-018103-czjjnlkf 54 5 a a DT cord-018103-czjjnlkf 54 6 query query NN cord-018103-czjjnlkf 54 7 to to IN cord-018103-czjjnlkf 54 8 the the DT cord-018103-czjjnlkf 54 9 FSFinder2 FSFinder2 NNP cord-018103-czjjnlkf 54 10 server server NN cord-018103-czjjnlkf 54 11 after after IN cord-018103-czjjnlkf 54 12 setting set VBG cord-018103-czjjnlkf 54 13 parameters parameter NNS cord-018103-czjjnlkf 54 14 or or CC cord-018103-czjjnlkf 54 15 defining define VBG cord-018103-czjjnlkf 54 16 a a DT cord-018103-czjjnlkf 54 17 new new JJ cord-018103-czjjnlkf 54 18 model model NN cord-018103-czjjnlkf 54 19 , , , cord-018103-czjjnlkf 54 20 all all PDT cord-018103-czjjnlkf 54 21 the the DT cord-018103-czjjnlkf 54 22 computations computation NNS cord-018103-czjjnlkf 54 23 are be VBP cord-018103-czjjnlkf 54 24 done do VBN cord-018103-czjjnlkf 54 25 on on IN cord-018103-czjjnlkf 54 26 the the DT cord-018103-czjjnlkf 54 27 server server NN cord-018103-czjjnlkf 54 28 side side NN cord-018103-czjjnlkf 54 29 . . . cord-018103-czjjnlkf 55 1 After after IN cord-018103-czjjnlkf 55 2 computation computation NN cord-018103-czjjnlkf 55 3 , , , cord-018103-czjjnlkf 55 4 the the DT cord-018103-czjjnlkf 55 5 server server NN cord-018103-czjjnlkf 55 6 sends send VBZ cord-018103-czjjnlkf 55 7 the the DT cord-018103-czjjnlkf 55 8 results result NNS cord-018103-czjjnlkf 55 9 to to IN cord-018103-czjjnlkf 55 10 the the DT cord-018103-czjjnlkf 55 11 user user NN cord-018103-czjjnlkf 55 12 . . . cord-018103-czjjnlkf 56 1 A a DT cord-018103-czjjnlkf 56 2 programmed programmed JJ cord-018103-czjjnlkf 56 3 -1 -1 NN cord-018103-czjjnlkf 56 4 ribosomal ribosomal JJ cord-018103-czjjnlkf 56 5 frameshift frameshift NN cord-018103-czjjnlkf 56 6 signal signal NN cord-018103-czjjnlkf 56 7 with with IN cord-018103-czjjnlkf 56 8 H h NN cord-018103-czjjnlkf 56 9 - - HYPH cord-018103-czjjnlkf 56 10 type type NN cord-018103-czjjnlkf 56 11 pseudoknot pseudoknot NN cord-018103-czjjnlkf 56 12 . . . cord-018103-czjjnlkf 57 1 Stem stem NN cord-018103-czjjnlkf 57 2 1 1 CD cord-018103-czjjnlkf 57 3 has have VBZ cord-018103-czjjnlkf 57 4 11 11 CD cord-018103-czjjnlkf 57 5 base base NN cord-018103-czjjnlkf 57 6 pairs pair NNS cord-018103-czjjnlkf 57 7 , , , cord-018103-czjjnlkf 57 8 stem stem NN cord-018103-czjjnlkf 57 9 2 2 CD cord-018103-czjjnlkf 57 10 has have VBZ cord-018103-czjjnlkf 57 11 6 6 CD cord-018103-czjjnlkf 57 12 base base NN cord-018103-czjjnlkf 57 13 pairs pair NNS cord-018103-czjjnlkf 57 14 , , , cord-018103-czjjnlkf 57 15 and and CC cord-018103-czjjnlkf 57 16 both both DT cord-018103-czjjnlkf 57 17 loops loop NNS cord-018103-czjjnlkf 57 18 of of IN cord-018103-czjjnlkf 57 19 the the DT cord-018103-czjjnlkf 57 20 pseudoknot pseudoknot NN cord-018103-czjjnlkf 57 21 have have VBP cord-018103-czjjnlkf 57 22 6 6 CD cord-018103-czjjnlkf 57 23 nucleotides nucleotide NNS cord-018103-czjjnlkf 57 24 . . . cord-018103-czjjnlkf 58 1 In in IN cord-018103-czjjnlkf 58 2 particular particular JJ cord-018103-czjjnlkf 58 3 , , , cord-018103-czjjnlkf 58 4 any any DT cord-018103-czjjnlkf 58 5 nucleotide nucleotide NN cord-018103-czjjnlkf 58 6 can can MD cord-018103-czjjnlkf 58 7 be be VB cord-018103-czjjnlkf 58 8 located locate VBN cord-018103-czjjnlkf 58 9 in in IN cord-018103-czjjnlkf 58 10 the the DT cord-018103-czjjnlkf 58 11 slippery slippery JJ cord-018103-czjjnlkf 58 12 site site NN cord-018103-czjjnlkf 58 13 not not RB cord-018103-czjjnlkf 58 14 the the DT cord-018103-czjjnlkf 58 15 same same JJ cord-018103-czjjnlkf 58 16 as as IN cord-018103-czjjnlkf 58 17 previous previous JJ cord-018103-czjjnlkf 58 18 work work NN cord-018103-czjjnlkf 58 19 . . . cord-018103-czjjnlkf 59 1 The the DT cord-018103-czjjnlkf 59 2 user user NN cord-018103-czjjnlkf 59 3 can can MD cord-018103-czjjnlkf 59 4 define define VB cord-018103-czjjnlkf 59 5 a a DT cord-018103-czjjnlkf 59 6 new new JJ cord-018103-czjjnlkf 59 7 model model NN cord-018103-czjjnlkf 59 8 by by IN cord-018103-czjjnlkf 59 9 specifying specify VBG cord-018103-czjjnlkf 59 10 its -PRON- PRP$ cord-018103-czjjnlkf 59 11 components component NNS cord-018103-czjjnlkf 59 12 and and CC cord-018103-czjjnlkf 59 13 their -PRON- PRP$ cord-018103-czjjnlkf 59 14 locations location NNS cord-018103-czjjnlkf 59 15 . . . cord-018103-czjjnlkf 60 1 To to TO cord-018103-czjjnlkf 60 2 analyze analyze VB cord-018103-czjjnlkf 60 3 E. E. NNP cord-018103-czjjnlkf 60 4 coli coli NNS cord-018103-czjjnlkf 60 5 genome genome NN cord-018103-czjjnlkf 60 6 , , , cord-018103-czjjnlkf 60 7 we -PRON- PRP cord-018103-czjjnlkf 60 8 set set VBD cord-018103-czjjnlkf 60 9 the the DT cord-018103-czjjnlkf 60 10 selection selection NN cord-018103-czjjnlkf 60 11 option option NN cord-018103-czjjnlkf 60 12 as as IN cord-018103-czjjnlkf 60 13 other other JJ cord-018103-czjjnlkf 60 14 genes gene NNS cord-018103-czjjnlkf 60 15 in in IN cord-018103-czjjnlkf 60 16 bacteria bacteria NNS cord-018103-czjjnlkf 60 17 , , , cord-018103-czjjnlkf 60 18 partial partial JJ cord-018103-czjjnlkf 60 19 sequence sequence NN cord-018103-czjjnlkf 60 20 and and CC cord-018103-czjjnlkf 60 21 +1 +1 NN cord-018103-czjjnlkf 60 22 strand strand NN cord-018103-czjjnlkf 60 23 . . . cord-018103-czjjnlkf 61 1 Because because IN cord-018103-czjjnlkf 61 2 we -PRON- PRP cord-018103-czjjnlkf 61 3 focused focus VBD cord-018103-czjjnlkf 61 4 on on IN cord-018103-czjjnlkf 61 5 -1 -1 . cord-018103-czjjnlkf 62 1 frameshift frameshift NN cord-018103-czjjnlkf 62 2 model model NN cord-018103-czjjnlkf 62 3 , , , cord-018103-czjjnlkf 62 4 we -PRON- PRP cord-018103-czjjnlkf 62 5 made make VBD cord-018103-czjjnlkf 62 6 a a DT cord-018103-czjjnlkf 62 7 model model NN cord-018103-czjjnlkf 62 8 which which WDT cord-018103-czjjnlkf 62 9 is be VBZ cord-018103-czjjnlkf 62 10 the the DT cord-018103-czjjnlkf 62 11 general general JJ cord-018103-czjjnlkf 62 12 motif motif NN cord-018103-czjjnlkf 62 13 X x NN cord-018103-czjjnlkf 62 14 XXY XXY NNP cord-018103-czjjnlkf 62 15 YYZ YYZ NNP cord-018103-czjjnlkf 62 16 of of IN cord-018103-czjjnlkf 62 17 the the DT cord-018103-czjjnlkf 62 18 -1 -1 NN cord-018103-czjjnlkf 62 19 frameshift frameshift NN cord-018103-czjjnlkf 62 20 . . . cord-018103-czjjnlkf 63 1 There there EX cord-018103-czjjnlkf 63 2 was be VBD cord-018103-czjjnlkf 63 3 no no DT cord-018103-czjjnlkf 63 4 limitation limitation NN cord-018103-czjjnlkf 63 5 of of IN cord-018103-czjjnlkf 63 6 frameshift frameshift NN cord-018103-czjjnlkf 63 7 site site NN cord-018103-czjjnlkf 63 8 , , , cord-018103-czjjnlkf 63 9 thus thus RB cord-018103-czjjnlkf 63 10 any any DT cord-018103-czjjnlkf 63 11 kind kind NN cord-018103-czjjnlkf 63 12 of of IN cord-018103-czjjnlkf 63 13 nucleotide nucleotide NN cord-018103-czjjnlkf 63 14 can can MD cord-018103-czjjnlkf 63 15 be be VB cord-018103-czjjnlkf 63 16 located locate VBN cord-018103-czjjnlkf 63 17 in in IN cord-018103-czjjnlkf 63 18 the the DT cord-018103-czjjnlkf 63 19 frameshift frameshift NN cord-018103-czjjnlkf 63 20 site site NN cord-018103-czjjnlkf 63 21 . . . cord-018103-czjjnlkf 64 1 For for IN cord-018103-czjjnlkf 64 2 downstream downstream JJ cord-018103-czjjnlkf 64 3 secondary secondary JJ cord-018103-czjjnlkf 64 4 structure structure NN cord-018103-czjjnlkf 64 5 , , , cord-018103-czjjnlkf 64 6 the the DT cord-018103-czjjnlkf 64 7 length length NN cord-018103-czjjnlkf 64 8 of of IN cord-018103-czjjnlkf 64 9 the the DT cord-018103-czjjnlkf 64 10 stems stem NNS cord-018103-czjjnlkf 64 11 and and CC cord-018103-czjjnlkf 64 12 loops loop NNS cord-018103-czjjnlkf 64 13 set set VBN cord-018103-czjjnlkf 64 14 by by IN cord-018103-czjjnlkf 64 15 default default NN cord-018103-czjjnlkf 64 16 . . . cord-018103-czjjnlkf 65 1 To to TO cord-018103-czjjnlkf 65 2 analyze analyze VB cord-018103-czjjnlkf 65 3 E. E. NNP cord-018103-czjjnlkf 65 4 coli coli NNS cord-018103-czjjnlkf 65 5 genome genome NN cord-018103-czjjnlkf 65 6 , , , cord-018103-czjjnlkf 65 7 we -PRON- PRP cord-018103-czjjnlkf 65 8 set set VBD cord-018103-czjjnlkf 65 9 the the DT cord-018103-czjjnlkf 65 10 selection selection NN cord-018103-czjjnlkf 65 11 option option NN cord-018103-czjjnlkf 65 12 as as IN cord-018103-czjjnlkf 65 13 other other JJ cord-018103-czjjnlkf 65 14 genes gene NNS cord-018103-czjjnlkf 65 15 in in IN cord-018103-czjjnlkf 65 16 bacteria bacteria NNS cord-018103-czjjnlkf 65 17 , , , cord-018103-czjjnlkf 65 18 partial partial JJ cord-018103-czjjnlkf 65 19 sequence sequence NN cord-018103-czjjnlkf 65 20 and and CC cord-018103-czjjnlkf 66 1 + + CC cord-018103-czjjnlkf 66 2 strand strand NN cord-018103-czjjnlkf 66 3 ( ( -LRB- cord-018103-czjjnlkf 66 4 Fig Fig NNP cord-018103-czjjnlkf 66 5 . . . cord-018103-czjjnlkf 66 6 2A 2a CD cord-018103-czjjnlkf 66 7 ) ) -RRB- cord-018103-czjjnlkf 66 8 . . . cord-018103-czjjnlkf 67 1 Because because IN cord-018103-czjjnlkf 67 2 we -PRON- PRP cord-018103-czjjnlkf 67 3 focused focus VBD cord-018103-czjjnlkf 67 4 on on IN cord-018103-czjjnlkf 67 5 -1 -1 . cord-018103-czjjnlkf 68 1 frameshift frameshift NN cord-018103-czjjnlkf 68 2 sites site NNS cord-018103-czjjnlkf 68 3 ( ( -LRB- cord-018103-czjjnlkf 68 4 Fig Fig NNP cord-018103-czjjnlkf 68 5 . . . cord-018103-czjjnlkf 68 6 2B 2b CD cord-018103-czjjnlkf 68 7 ) ) -RRB- cord-018103-czjjnlkf 69 1 , , , cord-018103-czjjnlkf 69 2 we -PRON- PRP cord-018103-czjjnlkf 69 3 defined define VBD cord-018103-czjjnlkf 69 4 a a DT cord-018103-czjjnlkf 69 5 signal signal NN cord-018103-czjjnlkf 69 6 that that WDT cord-018103-czjjnlkf 69 7 fits fit VBZ cord-018103-czjjnlkf 69 8 all all DT cord-018103-czjjnlkf 69 9 kinds kind NNS cord-018103-czjjnlkf 69 10 of of IN cord-018103-czjjnlkf 69 11 motif motif NN cord-018103-czjjnlkf 69 12 X x NN cord-018103-czjjnlkf 69 13 XXY XXY NNP cord-018103-czjjnlkf 69 14 YYZ YYZ NNP cord-018103-czjjnlkf 69 15 of of IN cord-018103-czjjnlkf 69 16 the the DT cord-018103-czjjnlkf 69 17 -1 -1 NN cord-018103-czjjnlkf 69 18 frameshift frameshift NN cord-018103-czjjnlkf 69 19 . . . cord-018103-czjjnlkf 70 1 There there EX cord-018103-czjjnlkf 70 2 was be VBD cord-018103-czjjnlkf 70 3 no no DT cord-018103-czjjnlkf 70 4 limitation limitation NN cord-018103-czjjnlkf 70 5 of of IN cord-018103-czjjnlkf 70 6 frameshift frameshift NN cord-018103-czjjnlkf 70 7 site site NN cord-018103-czjjnlkf 70 8 , , , cord-018103-czjjnlkf 70 9 thus thus RB cord-018103-czjjnlkf 70 10 any any DT cord-018103-czjjnlkf 70 11 kind kind NN cord-018103-czjjnlkf 70 12 of of IN cord-018103-czjjnlkf 70 13 nucleotide nucleotide NN cord-018103-czjjnlkf 70 14 can can MD cord-018103-czjjnlkf 70 15 be be VB cord-018103-czjjnlkf 70 16 located locate VBN cord-018103-czjjnlkf 70 17 in in IN cord-018103-czjjnlkf 70 18 the the DT cord-018103-czjjnlkf 70 19 frameshift frameshift NN cord-018103-czjjnlkf 70 20 site site NN cord-018103-czjjnlkf 70 21 . . . cord-018103-czjjnlkf 71 1 Thus thus RB cord-018103-czjjnlkf 71 2 we -PRON- PRP cord-018103-czjjnlkf 71 3 set set VBP cord-018103-czjjnlkf 71 4 the the DT cord-018103-czjjnlkf 71 5 match match NN cord-018103-czjjnlkf 71 6 type type NN cord-018103-czjjnlkf 71 7 as as IN cord-018103-czjjnlkf 71 8 NNN NNN NNP cord-018103-czjjnlkf 71 9 ( ( -LRB- cord-018103-czjjnlkf 71 10 N N NNP cord-018103-czjjnlkf 71 11 is be VBZ cord-018103-czjjnlkf 71 12 any any DT cord-018103-czjjnlkf 71 13 nucleotide nucleotide NN cord-018103-czjjnlkf 71 14 ) ) -RRB- cord-018103-czjjnlkf 71 15 and and CC cord-018103-czjjnlkf 71 16 no no DT cord-018103-czjjnlkf 71 17 exception exception NN cord-018103-czjjnlkf 71 18 of of IN cord-018103-czjjnlkf 71 19 arrangement arrangement NN cord-018103-czjjnlkf 71 20 . . . cord-018103-czjjnlkf 72 1 That that RB cord-018103-czjjnlkf 72 2 is is RB cord-018103-czjjnlkf 72 3 , , , cord-018103-czjjnlkf 72 4 frameshift frameshift NN cord-018103-czjjnlkf 72 5 site site NN cord-018103-czjjnlkf 72 6 can can MD cord-018103-czjjnlkf 72 7 occur occur VB cord-018103-czjjnlkf 72 8 even even RB cord-018103-czjjnlkf 72 9 at at IN cord-018103-czjjnlkf 72 10 A a DT cord-018103-czjjnlkf 72 11 AAA AAA NNP cord-018103-czjjnlkf 72 12 AAA aaa NN cord-018103-czjjnlkf 72 13 or or CC cord-018103-czjjnlkf 72 14 U U NNP cord-018103-czjjnlkf 72 15 UUU UUU NNP cord-018103-czjjnlkf 72 16 UUU UUU NNP cord-018103-czjjnlkf 72 17 . . . cord-018103-czjjnlkf 73 1 Default default NN cord-018103-czjjnlkf 73 2 values value NNS cord-018103-czjjnlkf 73 3 were be VBD cord-018103-czjjnlkf 73 4 used use VBN cord-018103-czjjnlkf 73 5 for for IN cord-018103-czjjnlkf 73 6 the the DT cord-018103-czjjnlkf 73 7 lengths length NNS cord-018103-czjjnlkf 73 8 of of IN cord-018103-czjjnlkf 73 9 the the DT cord-018103-czjjnlkf 73 10 stems stem NNS cord-018103-czjjnlkf 73 11 and and CC cord-018103-czjjnlkf 73 12 loops loop NNS cord-018103-czjjnlkf 73 13 in in IN cord-018103-czjjnlkf 73 14 the the DT cord-018103-czjjnlkf 73 15 downstream downstream JJ cord-018103-czjjnlkf 73 16 secondary secondary JJ cord-018103-czjjnlkf 73 17 structure structure NN cord-018103-czjjnlkf 73 18 ( ( -LRB- cord-018103-czjjnlkf 73 19 Fig Fig NNP cord-018103-czjjnlkf 73 20 . . . cord-018103-czjjnlkf 73 21 2C 2C NNP cord-018103-czjjnlkf 73 22 ) ) -RRB- cord-018103-czjjnlkf 73 23 . . . cord-018103-czjjnlkf 74 1 Fig Fig NNP cord-018103-czjjnlkf 74 2 . . . cord-018103-czjjnlkf 75 1 3 3 CD cord-018103-czjjnlkf 75 2 shows show VBZ cord-018103-czjjnlkf 75 3 the the DT cord-018103-czjjnlkf 75 4 XML xml NN cord-018103-czjjnlkf 75 5 schema schema NN cord-018103-czjjnlkf 75 6 for for IN cord-018103-czjjnlkf 75 7 the the DT cord-018103-czjjnlkf 75 8 parameters parameter NNS cord-018103-czjjnlkf 75 9 of of IN cord-018103-czjjnlkf 75 10 FSFinder2 FSFinder2 NNP cord-018103-czjjnlkf 75 11 . . . cord-018103-czjjnlkf 76 1 When when WRB cord-018103-czjjnlkf 76 2 the the DT cord-018103-czjjnlkf 76 3 user user NN cord-018103-czjjnlkf 76 4 sets set VBZ cord-018103-czjjnlkf 76 5 the the DT cord-018103-czjjnlkf 76 6 parameters parameter NNS cord-018103-czjjnlkf 76 7 of of IN cord-018103-czjjnlkf 76 8 a a DT cord-018103-czjjnlkf 76 9 model model NN cord-018103-czjjnlkf 76 10 in in IN cord-018103-czjjnlkf 76 11 the the DT cord-018103-czjjnlkf 76 12 web web NN cord-018103-czjjnlkf 76 13 page page NN cord-018103-czjjnlkf 76 14 of of IN cord-018103-czjjnlkf 76 15 the the DT cord-018103-czjjnlkf 76 16 FSFinder FSFinder NNP cord-018103-czjjnlkf 76 17 web web NN cord-018103-czjjnlkf 76 18 service service NN cord-018103-czjjnlkf 76 19 , , , cord-018103-czjjnlkf 76 20 the the DT cord-018103-czjjnlkf 76 21 parameters parameter NNS cord-018103-czjjnlkf 76 22 are be VBP cord-018103-czjjnlkf 76 23 converted convert VBN cord-018103-czjjnlkf 76 24 to to IN cord-018103-czjjnlkf 76 25 XML XML NNP cord-018103-czjjnlkf 76 26 . . . cord-018103-czjjnlkf 77 1 After after IN cord-018103-czjjnlkf 77 2 the the DT cord-018103-czjjnlkf 77 3 request request NN cord-018103-czjjnlkf 77 4 of of IN cord-018103-czjjnlkf 77 5 a a DT cord-018103-czjjnlkf 77 6 web web NN cord-018103-czjjnlkf 77 7 service service NN cord-018103-czjjnlkf 77 8 is be VBZ cord-018103-czjjnlkf 77 9 sent send VBN cord-018103-czjjnlkf 77 10 to to IN cord-018103-czjjnlkf 77 11 the the DT cord-018103-czjjnlkf 77 12 FSFinder FSFinder NNP cord-018103-czjjnlkf 77 13 server server NN cord-018103-czjjnlkf 77 14 , , , cord-018103-czjjnlkf 77 15 all all PDT cord-018103-czjjnlkf 77 16 the the DT cord-018103-czjjnlkf 77 17 computations computation NNS cord-018103-czjjnlkf 77 18 are be VBP cord-018103-czjjnlkf 77 19 done do VBN cord-018103-czjjnlkf 77 20 on on IN cord-018103-czjjnlkf 77 21 the the DT cord-018103-czjjnlkf 77 22 server server NN cord-018103-czjjnlkf 77 23 side side NN cord-018103-czjjnlkf 77 24 . . . cord-018103-czjjnlkf 78 1 Fig Fig NNP cord-018103-czjjnlkf 78 2 . . . cord-018103-czjjnlkf 79 1 4 4 LS cord-018103-czjjnlkf 79 2 shows show VBZ cord-018103-czjjnlkf 79 3 the the DT cord-018103-czjjnlkf 79 4 frameshift frameshift NN cord-018103-czjjnlkf 79 5 site site NN cord-018103-czjjnlkf 79 6 of of IN cord-018103-czjjnlkf 79 7 the the DT cord-018103-czjjnlkf 79 8 genome genome NN cord-018103-czjjnlkf 79 9 of of IN cord-018103-czjjnlkf 79 10 SARS SARS NNP cord-018103-czjjnlkf 79 11 corona corona NNP cord-018103-czjjnlkf 79 12 virus virus NN cord-018103-czjjnlkf 79 13 ( ( -LRB- cord-018103-czjjnlkf 79 14 NC_004718 nc_004718 NN cord-018103-czjjnlkf 79 15 ) ) -RRB- cord-018103-czjjnlkf 79 16 . . . cord-018103-czjjnlkf 80 1 ORF1a ORF1a NNP cord-018103-czjjnlkf 80 2 ( ( -LRB- cord-018103-czjjnlkf 80 3 265 265 CD cord-018103-czjjnlkf 80 4 .. .. CD cord-018103-czjjnlkf 80 5 13398 13398 CD cord-018103-czjjnlkf 80 6 ) ) -RRB- cord-018103-czjjnlkf 81 1 and and CC cord-018103-czjjnlkf 81 2 ORF1b ORF1b NNP cord-018103-czjjnlkf 81 3 ( ( -LRB- cord-018103-czjjnlkf 81 4 13398 13398 CD cord-018103-czjjnlkf 81 5 .. .. . cord-018103-czjjnlkf 82 1 21485 21485 CD cord-018103-czjjnlkf 82 2 ) ) -RRB- cord-018103-czjjnlkf 82 3 partially partially RB cord-018103-czjjnlkf 82 4 overlap overlap VBP cord-018103-czjjnlkf 82 5 each each DT cord-018103-czjjnlkf 82 6 other other JJ cord-018103-czjjnlkf 82 7 . . . cord-018103-czjjnlkf 83 1 U U NNP cord-018103-czjjnlkf 83 2 UUA UUA NNP cord-018103-czjjnlkf 83 3 AAC AAC NNP cord-018103-czjjnlkf 83 4 is be VBZ cord-018103-czjjnlkf 83 5 the the DT cord-018103-czjjnlkf 83 6 slippery slippery JJ cord-018103-czjjnlkf 83 7 sequence sequence NN cord-018103-czjjnlkf 83 8 and and CC cord-018103-czjjnlkf 83 9 the the DT cord-018103-czjjnlkf 83 10 secondary secondary JJ cord-018103-czjjnlkf 83 11 structure structure NN cord-018103-czjjnlkf 83 12 is be VBZ cord-018103-czjjnlkf 83 13 a a DT cord-018103-czjjnlkf 83 14 pseudoknot pseudoknot NN cord-018103-czjjnlkf 83 15 [ [ -LRB- cord-018103-czjjnlkf 83 16 8 8 CD cord-018103-czjjnlkf 83 17 ] ] -RRB- cord-018103-czjjnlkf 83 18 . . . cord-018103-czjjnlkf 84 1 In in IN cord-018103-czjjnlkf 84 2 the the DT cord-018103-czjjnlkf 84 3 GenBank GenBank NNP cord-018103-czjjnlkf 84 4 description description NN cord-018103-czjjnlkf 84 5 , , , cord-018103-czjjnlkf 84 6 the the DT cord-018103-czjjnlkf 84 7 overlapping overlap VBG cord-018103-czjjnlkf 84 8 region region NN cord-018103-czjjnlkf 84 9 of of IN cord-018103-czjjnlkf 84 10 ORF1a ORF1a NNP cord-018103-czjjnlkf 84 11 and and CC cord-018103-czjjnlkf 84 12 ORF1b ORF1b NNP cord-018103-czjjnlkf 84 13 has have VBZ cord-018103-czjjnlkf 84 14 only only RB cord-018103-czjjnlkf 84 15 one one CD cord-018103-czjjnlkf 84 16 1 1 CD cord-018103-czjjnlkf 84 17 nucleotide nucleotide NN cord-018103-czjjnlkf 84 18 . . . cord-018103-czjjnlkf 85 1 ORF1b ORF1b NNP cord-018103-czjjnlkf 85 2 starts start VBZ cord-018103-czjjnlkf 85 3 from from IN cord-018103-czjjnlkf 85 4 codon codon NN cord-018103-czjjnlkf 85 5 AAA AAA NNP cord-018103-czjjnlkf 85 6 instead instead RB cord-018103-czjjnlkf 85 7 of of IN cord-018103-czjjnlkf 85 8 a a DT cord-018103-czjjnlkf 85 9 regular regular JJ cord-018103-czjjnlkf 85 10 start start NN cord-018103-czjjnlkf 85 11 codon codon NN cord-018103-czjjnlkf 85 12 . . . cord-018103-czjjnlkf 86 1 The the DT cord-018103-czjjnlkf 86 2 start start NN cord-018103-czjjnlkf 86 3 codon codon NN cord-018103-czjjnlkf 86 4 of of IN cord-018103-czjjnlkf 86 5 ORF2 ORF2 NNP cord-018103-czjjnlkf 86 6 ( ( -LRB- cord-018103-czjjnlkf 86 7 red red JJ cord-018103-czjjnlkf 86 8 triangle triangle NN cord-018103-czjjnlkf 86 9 ) ) -RRB- cord-018103-czjjnlkf 86 10 exists exist VBZ cord-018103-czjjnlkf 86 11 outside outside IN cord-018103-czjjnlkf 86 12 the the DT cord-018103-czjjnlkf 86 13 overlapping overlap VBG cord-018103-czjjnlkf 86 14 region region NN cord-018103-czjjnlkf 86 15 . . . cord-018103-czjjnlkf 87 1 Frameshifting Frameshifting NNP cord-018103-czjjnlkf 87 2 can can MD cord-018103-czjjnlkf 87 3 occur occur VB cord-018103-czjjnlkf 87 4 even even RB cord-018103-czjjnlkf 87 5 in in IN cord-018103-czjjnlkf 87 6 overlapping overlap VBG cord-018103-czjjnlkf 87 7 regions region NNS cord-018103-czjjnlkf 87 8 with with IN cord-018103-czjjnlkf 87 9 1 1 CD cord-018103-czjjnlkf 87 10 nucleotide nucleotide NN cord-018103-czjjnlkf 87 11 . . . cord-018103-czjjnlkf 88 1 To to TO cord-018103-czjjnlkf 88 2 solve solve VB cord-018103-czjjnlkf 88 3 these these DT cord-018103-czjjnlkf 88 4 problems problem NNS cord-018103-czjjnlkf 88 5 , , , cord-018103-czjjnlkf 88 6 finding find VBG cord-018103-czjjnlkf 88 7 an an DT cord-018103-czjjnlkf 88 8 overlapping overlap VBG cord-018103-czjjnlkf 88 9 region region NN cord-018103-czjjnlkf 88 10 is be VBZ cord-018103-czjjnlkf 88 11 divided divide VBN cord-018103-czjjnlkf 88 12 into into IN cord-018103-czjjnlkf 88 13 two two CD cord-018103-czjjnlkf 88 14 processes process NNS cord-018103-czjjnlkf 88 15 : : : cord-018103-czjjnlkf 88 16 finding find VBG cord-018103-czjjnlkf 88 17 motifs motif NNS cord-018103-czjjnlkf 88 18 and and CC cord-018103-czjjnlkf 88 19 finding find VBG cord-018103-czjjnlkf 88 20 overlapping overlap VBG cord-018103-czjjnlkf 88 21 regions region NNS cord-018103-czjjnlkf 88 22 . . . cord-018103-czjjnlkf 89 1 The the DT cord-018103-czjjnlkf 89 2 shape shape NN cord-018103-czjjnlkf 89 3 of of IN cord-018103-czjjnlkf 89 4 an an DT cord-018103-czjjnlkf 89 5 overlapping overlap VBG cord-018103-czjjnlkf 89 6 region region NN cord-018103-czjjnlkf 89 7 is be VBZ cord-018103-czjjnlkf 89 8 considered consider VBN cord-018103-czjjnlkf 89 9 to to TO cord-018103-czjjnlkf 89 10 find find VB cord-018103-czjjnlkf 89 11 an an DT cord-018103-czjjnlkf 89 12 overlapping overlap VBG cord-018103-czjjnlkf 89 13 region region NN cord-018103-czjjnlkf 89 14 . . . cord-018103-czjjnlkf 90 1 As as IN cord-018103-czjjnlkf 90 2 shown show VBN cord-018103-czjjnlkf 90 3 in in IN cord-018103-czjjnlkf 90 4 Fig Fig NNP cord-018103-czjjnlkf 90 5 . . . cord-018103-czjjnlkf 91 1 5 5 LS cord-018103-czjjnlkf 91 2 , , , cord-018103-czjjnlkf 91 3 the the DT cord-018103-czjjnlkf 91 4 overlapping overlap VBG cord-018103-czjjnlkf 91 5 region region NN cord-018103-czjjnlkf 91 6 is be VBZ cord-018103-czjjnlkf 91 7 extended extend VBN cord-018103-czjjnlkf 91 8 from from IN cord-018103-czjjnlkf 91 9 stop stop NN cord-018103-czjjnlkf 91 10 codon codon NN cord-018103-czjjnlkf 91 11 1 1 CD cord-018103-czjjnlkf 91 12 of of IN cord-018103-czjjnlkf 91 13 open open JJ cord-018103-czjjnlkf 91 14 reading reading NN cord-018103-czjjnlkf 91 15 frame frame NN cord-018103-czjjnlkf 91 16 2 2 CD cord-018103-czjjnlkf 91 17 to to TO cord-018103-czjjnlkf 91 18 stop stop VB cord-018103-czjjnlkf 91 19 codon codon NN cord-018103-czjjnlkf 91 20 2 2 CD cord-018103-czjjnlkf 91 21 of of IN cord-018103-czjjnlkf 91 22 open open JJ cord-018103-czjjnlkf 91 23 reading reading NN cord-018103-czjjnlkf 91 24 frame frame NN cord-018103-czjjnlkf 91 25 1 1 CD cord-018103-czjjnlkf 91 26 ( ( -LRB- cord-018103-czjjnlkf 91 27 green green JJ cord-018103-czjjnlkf 91 28 color color NN cord-018103-czjjnlkf 91 29 ) ) -RRB- cord-018103-czjjnlkf 91 30 . . . cord-018103-czjjnlkf 92 1 The the DT cord-018103-czjjnlkf 92 2 minimum minimum JJ cord-018103-czjjnlkf 92 3 length length NN cord-018103-czjjnlkf 92 4 of of IN cord-018103-czjjnlkf 92 5 both both DT cord-018103-czjjnlkf 92 6 genes gene NNS cord-018103-czjjnlkf 92 7 should should MD cord-018103-czjjnlkf 92 8 be be VB cord-018103-czjjnlkf 92 9 longer long JJR cord-018103-czjjnlkf 92 10 than than IN cord-018103-czjjnlkf 92 11 100 100 CD cord-018103-czjjnlkf 92 12 nucleotides nucleotide NNS cord-018103-czjjnlkf 92 13 , , , cord-018103-czjjnlkf 92 14 and and CC cord-018103-czjjnlkf 92 15 the the DT cord-018103-czjjnlkf 92 16 length length NN cord-018103-czjjnlkf 92 17 of of IN cord-018103-czjjnlkf 92 18 the the DT cord-018103-czjjnlkf 92 19 overlapping overlap VBG cord-018103-czjjnlkf 92 20 region region NN cord-018103-czjjnlkf 92 21 should should MD cord-018103-czjjnlkf 92 22 be be VB cord-018103-czjjnlkf 92 23 longer long JJR cord-018103-czjjnlkf 92 24 than than IN cord-018103-czjjnlkf 92 25 30 30 CD cord-018103-czjjnlkf 92 26 nucleotides nucleotide NNS cord-018103-czjjnlkf 92 27 . . . cord-018103-czjjnlkf 93 1 In in IN cord-018103-czjjnlkf 93 2 addition addition NN cord-018103-czjjnlkf 93 3 , , , cord-018103-czjjnlkf 93 4 the the DT cord-018103-czjjnlkf 93 5 location location NN cord-018103-czjjnlkf 93 6 of of IN cord-018103-czjjnlkf 93 7 the the DT cord-018103-czjjnlkf 93 8 start start NN cord-018103-czjjnlkf 93 9 codon codon NN cord-018103-czjjnlkf 93 10 of of IN cord-018103-czjjnlkf 93 11 ORF2 ORF2 NNP cord-018103-czjjnlkf 93 12 does do VBZ cord-018103-czjjnlkf 93 13 not not RB cord-018103-czjjnlkf 93 14 matter matter VB cord-018103-czjjnlkf 93 15 . . . cord-018103-czjjnlkf 94 1 As as IN cord-018103-czjjnlkf 94 2 in in IN cord-018103-czjjnlkf 94 3 the the DT cord-018103-czjjnlkf 94 4 SARS SARS NNP cord-018103-czjjnlkf 94 5 corona corona NNP cord-018103-czjjnlkf 94 6 virus virus NN cord-018103-czjjnlkf 94 7 , , , cord-018103-czjjnlkf 94 8 the the DT cord-018103-czjjnlkf 94 9 start start NN cord-018103-czjjnlkf 94 10 codon codon NN cord-018103-czjjnlkf 94 11 is be VBZ cord-018103-czjjnlkf 94 12 not not RB cord-018103-czjjnlkf 94 13 always always RB cord-018103-czjjnlkf 94 14 located locate VBN cord-018103-czjjnlkf 94 15 in in IN cord-018103-czjjnlkf 94 16 the the DT cord-018103-czjjnlkf 94 17 overlapping overlap VBG cord-018103-czjjnlkf 94 18 region region NN cord-018103-czjjnlkf 94 19 of of IN cord-018103-czjjnlkf 94 20 frameshifting frameshifte VBG cord-018103-czjjnlkf 94 21 genes gene NNS cord-018103-czjjnlkf 94 22 . . . cord-018103-czjjnlkf 94 23 _SP cord-018103-czjjnlkf 95 1 Additional additional JJ cord-018103-czjjnlkf 95 2 method method NN cord-018103-czjjnlkf 95 3 to to TO cord-018103-czjjnlkf 95 4 find find VB cord-018103-czjjnlkf 95 5 overlapping overlapping JJ cord-018103-czjjnlkf 95 6 regions region NNS cord-018103-czjjnlkf 95 7 is be VBZ cord-018103-czjjnlkf 95 8 to to TO cord-018103-czjjnlkf 95 9 use use VB cord-018103-czjjnlkf 95 10 the the DT cord-018103-czjjnlkf 95 11 description description NN cord-018103-czjjnlkf 95 12 of of IN cord-018103-czjjnlkf 95 13 the the DT cord-018103-czjjnlkf 95 14 Gen Gen NNP cord-018103-czjjnlkf 95 15 - - HYPH cord-018103-czjjnlkf 95 16 Bank Bank NNP cord-018103-czjjnlkf 95 17 file file NN cord-018103-czjjnlkf 95 18 . . . cord-018103-czjjnlkf 96 1 If if IN cord-018103-czjjnlkf 96 2 more more JJR cord-018103-czjjnlkf 96 3 than than IN cord-018103-czjjnlkf 96 4 1 1 CD cord-018103-czjjnlkf 96 5 nucleotide nucleotide NN cord-018103-czjjnlkf 96 6 is be VBZ cord-018103-czjjnlkf 96 7 overlapped overlap VBN cord-018103-czjjnlkf 96 8 , , , cord-018103-czjjnlkf 96 9 we -PRON- PRP cord-018103-czjjnlkf 96 10 consider consider VBP cord-018103-czjjnlkf 96 11 two two CD cord-018103-czjjnlkf 96 12 open open JJ cord-018103-czjjnlkf 96 13 reading reading NN cord-018103-czjjnlkf 96 14 frames frame NNS cord-018103-czjjnlkf 96 15 as as IN cord-018103-czjjnlkf 96 16 a a DT cord-018103-czjjnlkf 96 17 candidate candidate NN cord-018103-czjjnlkf 96 18 of of IN cord-018103-czjjnlkf 96 19 partially partially RB cord-018103-czjjnlkf 96 20 overlapping overlap VBG cord-018103-czjjnlkf 96 21 genes gene NNS cord-018103-czjjnlkf 96 22 . . . cord-018103-czjjnlkf 97 1 Finally finally RB cord-018103-czjjnlkf 97 2 , , , cord-018103-czjjnlkf 97 3 the the DT cord-018103-czjjnlkf 97 4 overlapping overlap VBG cord-018103-czjjnlkf 97 5 regions region NNS cord-018103-czjjnlkf 97 6 found find VBD cord-018103-czjjnlkf 97 7 both both CC cord-018103-czjjnlkf 97 8 by by IN cord-018103-czjjnlkf 97 9 FSFinder FSFinder NNS cord-018103-czjjnlkf 97 10 and and CC cord-018103-czjjnlkf 97 11 by by IN cord-018103-czjjnlkf 97 12 the the DT cord-018103-czjjnlkf 97 13 GenBank GenBank NNP cord-018103-czjjnlkf 97 14 description description NN cord-018103-czjjnlkf 97 15 are be VBP cord-018103-czjjnlkf 97 16 used use VBN cord-018103-czjjnlkf 97 17 for for IN cord-018103-czjjnlkf 97 18 further further JJ cord-018103-czjjnlkf 97 19 analysis analysis NN cord-018103-czjjnlkf 97 20 . . . cord-018103-czjjnlkf 97 21 _SP cord-018103-czjjnlkf 98 1 The the DT cord-018103-czjjnlkf 98 2 E. E. NNP cord-018103-czjjnlkf 98 3 coli coli VBZ cord-018103-czjjnlkf 98 4 K12 K12 NNP cord-018103-czjjnlkf 98 5 genome genome NN cord-018103-czjjnlkf 98 6 sequence sequence NN cord-018103-czjjnlkf 98 7 ( ( -LRB- cord-018103-czjjnlkf 98 8 NC_000913 NC_000913 NNP cord-018103-czjjnlkf 98 9 ) ) -RRB- cord-018103-czjjnlkf 98 10 was be VBD cord-018103-czjjnlkf 98 11 obtained obtain VBN cord-018103-czjjnlkf 98 12 from from IN cord-018103-czjjnlkf 98 13 GenBank GenBank NNP cord-018103-czjjnlkf 98 14 . . . cord-018103-czjjnlkf 99 1 As as IN cord-018103-czjjnlkf 99 2 shown show VBN cord-018103-czjjnlkf 99 3 in in IN cord-018103-czjjnlkf 99 4 Fig Fig NNP cord-018103-czjjnlkf 99 5 . . . cord-018103-czjjnlkf 100 1 6 6 CD cord-018103-czjjnlkf 100 2 , , , cord-018103-czjjnlkf 100 3 all all PDT cord-018103-czjjnlkf 100 4 the the DT cord-018103-czjjnlkf 100 5 heptameric heptameric JJ cord-018103-czjjnlkf 100 6 sequences sequence NNS cord-018103-czjjnlkf 100 7 that that WDT cord-018103-czjjnlkf 100 8 follow follow VBP cord-018103-czjjnlkf 100 9 X X NNP cord-018103-czjjnlkf 100 10 XXY XXY NNP cord-018103-czjjnlkf 100 11 YYZ YYZ NNP cord-018103-czjjnlkf 100 12 motif motif NN cord-018103-czjjnlkf 100 13 were be VBD cord-018103-czjjnlkf 100 14 Fig Fig NNP cord-018103-czjjnlkf 100 15 . . . cord-018103-czjjnlkf 100 16 6 6 CD cord-018103-czjjnlkf 100 17 . . . cord-018103-czjjnlkf 101 1 The the DT cord-018103-czjjnlkf 101 2 prediction prediction NN cord-018103-czjjnlkf 101 3 process process NN cord-018103-czjjnlkf 101 4 of of IN cord-018103-czjjnlkf 101 5 frameshift frameshift NN cord-018103-czjjnlkf 101 6 sites site NNS cord-018103-czjjnlkf 101 7 from from IN cord-018103-czjjnlkf 101 8 the the DT cord-018103-czjjnlkf 101 9 Escherichia Escherichia NNP cord-018103-czjjnlkf 101 10 coli coli NNS cord-018103-czjjnlkf 101 11 K K NNP cord-018103-czjjnlkf 101 12 12 12 CD cord-018103-czjjnlkf 101 13 genome genome NN cord-018103-czjjnlkf 101 14 sequence sequence NN cord-018103-czjjnlkf 101 15 examined examine VBN cord-018103-czjjnlkf 101 16 . . . cord-018103-czjjnlkf 102 1 As as IN cord-018103-czjjnlkf 102 2 a a DT cord-018103-czjjnlkf 102 3 result result NN cord-018103-czjjnlkf 102 4 of of IN cord-018103-czjjnlkf 102 5 this this DT cord-018103-czjjnlkf 102 6 process process NN cord-018103-czjjnlkf 102 7 18,401 18,401 CD cord-018103-czjjnlkf 102 8 sites site NNS cord-018103-czjjnlkf 102 9 were be VBD cord-018103-czjjnlkf 102 10 found find VBN cord-018103-czjjnlkf 102 11 . . . cord-018103-czjjnlkf 103 1 Whether whether IN cord-018103-czjjnlkf 103 2 these these DT cord-018103-czjjnlkf 103 3 sites site NNS cord-018103-czjjnlkf 103 4 are be VBP cord-018103-czjjnlkf 103 5 located locate VBN cord-018103-czjjnlkf 103 6 in in IN cord-018103-czjjnlkf 103 7 the the DT cord-018103-czjjnlkf 103 8 overlapping overlap VBG cord-018103-czjjnlkf 103 9 region region NN cord-018103-czjjnlkf 103 10 or or CC cord-018103-czjjnlkf 103 11 not not RB cord-018103-czjjnlkf 103 12 was be VBD cord-018103-czjjnlkf 103 13 not not RB cord-018103-czjjnlkf 103 14 considered consider VBN cord-018103-czjjnlkf 103 15 when when WRB cord-018103-czjjnlkf 103 16 finding find VBG cord-018103-czjjnlkf 103 17 these these DT cord-018103-czjjnlkf 103 18 sites site NNS cord-018103-czjjnlkf 103 19 . . . cord-018103-czjjnlkf 104 1 For for IN cord-018103-czjjnlkf 104 2 overlapping overlap VBG cord-018103-czjjnlkf 104 3 regions region NNS cord-018103-czjjnlkf 104 4 of of IN cord-018103-czjjnlkf 104 5 ORFs ORFs NNP cord-018103-czjjnlkf 104 6 , , , cord-018103-czjjnlkf 104 7 we -PRON- PRP cord-018103-czjjnlkf 104 8 found find VBD cord-018103-czjjnlkf 104 9 312 312 CD cord-018103-czjjnlkf 104 10 candidate candidate NN cord-018103-czjjnlkf 104 11 regions region NNS cord-018103-czjjnlkf 104 12 that that WDT cord-018103-czjjnlkf 104 13 were be VBD cord-018103-czjjnlkf 104 14 partially partially RB cord-018103-czjjnlkf 104 15 overlapped overlap VBN cord-018103-czjjnlkf 104 16 more more JJR cord-018103-czjjnlkf 104 17 than than IN cord-018103-czjjnlkf 104 18 1 1 CD cord-018103-czjjnlkf 104 19 base base NN cord-018103-czjjnlkf 104 20 according accord VBG cord-018103-czjjnlkf 104 21 to to IN cord-018103-czjjnlkf 104 22 the the DT cord-018103-czjjnlkf 104 23 GenBank GenBank NNP cord-018103-czjjnlkf 104 24 description description NN cord-018103-czjjnlkf 104 25 and and CC cord-018103-czjjnlkf 104 26 309 309 CD cord-018103-czjjnlkf 104 27 candidate candidate NN cord-018103-czjjnlkf 104 28 regions region NNS cord-018103-czjjnlkf 104 29 that that WDT cord-018103-czjjnlkf 104 30 were be VBD cord-018103-czjjnlkf 104 31 overlapped overlap VBN cord-018103-czjjnlkf 104 32 more more JJR cord-018103-czjjnlkf 104 33 than than IN cord-018103-czjjnlkf 104 34 30 30 CD cord-018103-czjjnlkf 104 35 bases basis NNS cord-018103-czjjnlkf 104 36 using use VBG cord-018103-czjjnlkf 104 37 the the DT cord-018103-czjjnlkf 104 38 FSFinder FSFinder NNP cord-018103-czjjnlkf 104 39 web web NN cord-018103-czjjnlkf 104 40 service service NN cord-018103-czjjnlkf 104 41 . . . cord-018103-czjjnlkf 105 1 After after IN cord-018103-czjjnlkf 105 2 removing remove VBG cord-018103-czjjnlkf 105 3 redundant redundant JJ cord-018103-czjjnlkf 105 4 sites site NNS cord-018103-czjjnlkf 105 5 , , , cord-018103-czjjnlkf 105 6 we -PRON- PRP cord-018103-czjjnlkf 105 7 obtained obtain VBD cord-018103-czjjnlkf 105 8 195 195 CD cord-018103-czjjnlkf 105 9 overlapping overlap VBG cord-018103-czjjnlkf 105 10 regions region NNS cord-018103-czjjnlkf 105 11 . . . cord-018103-czjjnlkf 106 1 From from IN cord-018103-czjjnlkf 106 2 these these DT cord-018103-czjjnlkf 106 3 regions region NNS cord-018103-czjjnlkf 106 4 , , , cord-018103-czjjnlkf 106 5 heptameric heptameric NN cord-018103-czjjnlkf 106 6 sequences sequence NNS cord-018103-czjjnlkf 106 7 that that WDT cord-018103-czjjnlkf 106 8 were be VBD cord-018103-czjjnlkf 106 9 not not RB cord-018103-czjjnlkf 106 10 located locate VBN cord-018103-czjjnlkf 106 11 in in IN cord-018103-czjjnlkf 106 12 the the DT cord-018103-czjjnlkf 106 13 overlapping overlap VBG cord-018103-czjjnlkf 106 14 region region NN cord-018103-czjjnlkf 106 15 were be VBD cord-018103-czjjnlkf 106 16 filtered filter VBN cord-018103-czjjnlkf 106 17 out out RP cord-018103-czjjnlkf 106 18 . . . cord-018103-czjjnlkf 107 1 Just just RB cord-018103-czjjnlkf 107 2 66 66 CD cord-018103-czjjnlkf 107 3 sites site NNS cord-018103-czjjnlkf 107 4 remained remain VBD cord-018103-czjjnlkf 107 5 in in IN cord-018103-czjjnlkf 107 6 the the DT cord-018103-czjjnlkf 107 7 overlapping overlap VBG cord-018103-czjjnlkf 107 8 regions region NNS cord-018103-czjjnlkf 107 9 . . . cord-018103-czjjnlkf 108 1 From from IN cord-018103-czjjnlkf 108 2 the the DT cord-018103-czjjnlkf 108 3 gene gene NN cord-018103-czjjnlkf 108 4 length length NN cord-018103-czjjnlkf 108 5 , , , cord-018103-czjjnlkf 108 6 shape shape NN cord-018103-czjjnlkf 108 7 and and CC cord-018103-czjjnlkf 108 8 the the DT cord-018103-czjjnlkf 108 9 length length NN cord-018103-czjjnlkf 108 10 of of IN cord-018103-czjjnlkf 108 11 the the DT cord-018103-czjjnlkf 108 12 overlapping overlap VBG cord-018103-czjjnlkf 108 13 region region NN cord-018103-czjjnlkf 108 14 , , , cord-018103-czjjnlkf 108 15 11 11 CD cord-018103-czjjnlkf 108 16 sites site NNS cord-018103-czjjnlkf 108 17 including include VBG cord-018103-czjjnlkf 108 18 3 3 CD cord-018103-czjjnlkf 108 19 known know VBN cord-018103-czjjnlkf 108 20 frameshift frameshift NN cord-018103-czjjnlkf 108 21 sites site NNS cord-018103-czjjnlkf 108 22 were be VBD cord-018103-czjjnlkf 108 23 identified identify VBN cord-018103-czjjnlkf 108 24 as as IN cord-018103-czjjnlkf 108 25 significant significant JJ cord-018103-czjjnlkf 108 26 candidates candidate NNS cord-018103-czjjnlkf 108 27 . . . cord-018103-czjjnlkf 109 1 This this DT cord-018103-czjjnlkf 109 2 process process NN cord-018103-czjjnlkf 109 3 consists consist VBZ cord-018103-czjjnlkf 109 4 of of IN cord-018103-czjjnlkf 109 5 two two CD cord-018103-czjjnlkf 109 6 sub sub NN cord-018103-czjjnlkf 109 7 - - NNS cord-018103-czjjnlkf 109 8 processes process NNS cord-018103-czjjnlkf 109 9 : : : cord-018103-czjjnlkf 109 10 finding find VBG cord-018103-czjjnlkf 109 11 motifs motif NNS cord-018103-czjjnlkf 109 12 and and CC cord-018103-czjjnlkf 109 13 finding find VBG cord-018103-czjjnlkf 109 14 overlapping overlap VBG cord-018103-czjjnlkf 109 15 regions region NNS cord-018103-czjjnlkf 109 16 . . . cord-018103-czjjnlkf 110 1 The the DT cord-018103-czjjnlkf 110 2 E. E. NNP cord-018103-czjjnlkf 110 3 coli coli VBZ cord-018103-czjjnlkf 110 4 K K NNP cord-018103-czjjnlkf 110 5 12 12 CD cord-018103-czjjnlkf 110 6 genome genome NN cord-018103-czjjnlkf 110 7 sequence sequence NN cord-018103-czjjnlkf 110 8 ( ( -LRB- cord-018103-czjjnlkf 110 9 NC_000913 NC_000913 NNP cord-018103-czjjnlkf 110 10 ) ) -RRB- cord-018103-czjjnlkf 110 11 was be VBD cord-018103-czjjnlkf 110 12 obtained obtain VBN cord-018103-czjjnlkf 110 13 from from IN cord-018103-czjjnlkf 110 14 the the DT cord-018103-czjjnlkf 110 15 GenBank GenBank NNP cord-018103-czjjnlkf 110 16 . . . cord-018103-czjjnlkf 111 1 To to TO cord-018103-czjjnlkf 111 2 find find VB cord-018103-czjjnlkf 111 3 motifs motif NNS cord-018103-czjjnlkf 111 4 , , , cord-018103-czjjnlkf 111 5 all all PDT cord-018103-czjjnlkf 111 6 the the DT cord-018103-czjjnlkf 111 7 heptameric heptameric JJ cord-018103-czjjnlkf 111 8 sequences sequence NNS cord-018103-czjjnlkf 111 9 that that WDT cord-018103-czjjnlkf 111 10 follow follow VBP cord-018103-czjjnlkf 111 11 X X NNP cord-018103-czjjnlkf 111 12 XXY XXY NNP cord-018103-czjjnlkf 111 13 YYZ YYZ NNP cord-018103-czjjnlkf 111 14 motif motif NN cord-018103-czjjnlkf 111 15 were be VBD cord-018103-czjjnlkf 111 16 found find VBN cord-018103-czjjnlkf 111 17 . . . cord-018103-czjjnlkf 112 1 18,401 18,401 CD cord-018103-czjjnlkf 112 2 sites site NNS cord-018103-czjjnlkf 112 3 were be VBD cord-018103-czjjnlkf 112 4 detected detect VBN cord-018103-czjjnlkf 112 5 . . . cord-018103-czjjnlkf 113 1 According accord VBG cord-018103-czjjnlkf 113 2 to to IN cord-018103-czjjnlkf 113 3 the the DT cord-018103-czjjnlkf 113 4 GenBank GenBank NNP cord-018103-czjjnlkf 113 5 description description NN cord-018103-czjjnlkf 113 6 , , , cord-018103-czjjnlkf 113 7 there there EX cord-018103-czjjnlkf 113 8 were be VBD cord-018103-czjjnlkf 113 9 312 312 CD cord-018103-czjjnlkf 113 10 candidate candidate NN cord-018103-czjjnlkf 113 11 overlapping overlap VBG cord-018103-czjjnlkf 113 12 regions region NNS cord-018103-czjjnlkf 113 13 that that WDT cord-018103-czjjnlkf 113 14 were be VBD cord-018103-czjjnlkf 113 15 partially partially RB cord-018103-czjjnlkf 113 16 overlapped overlap VBN cord-018103-czjjnlkf 113 17 more more JJR cord-018103-czjjnlkf 113 18 than than IN cord-018103-czjjnlkf 113 19 1 1 CD cord-018103-czjjnlkf 113 20 base base NN cord-018103-czjjnlkf 113 21 in in RB cord-018103-czjjnlkf 113 22 . . . cord-018103-czjjnlkf 114 1 The the DT cord-018103-czjjnlkf 114 2 FSFinder FSFinder NNP cord-018103-czjjnlkf 114 3 web web NN cord-018103-czjjnlkf 114 4 service service NN cord-018103-czjjnlkf 114 5 found find VBD cord-018103-czjjnlkf 114 6 309 309 CD cord-018103-czjjnlkf 114 7 candidate candidate NN cord-018103-czjjnlkf 114 8 overlapping overlap VBG cord-018103-czjjnlkf 114 9 regions region NNS cord-018103-czjjnlkf 114 10 that that WDT cord-018103-czjjnlkf 114 11 were be VBD cord-018103-czjjnlkf 114 12 overlapped overlap VBN cord-018103-czjjnlkf 114 13 more more JJR cord-018103-czjjnlkf 114 14 than than IN cord-018103-czjjnlkf 114 15 30 30 CD cord-018103-czjjnlkf 114 16 bases basis NNS cord-018103-czjjnlkf 114 17 . . . cord-018103-czjjnlkf 115 1 After after IN cord-018103-czjjnlkf 115 2 removing remove VBG cord-018103-czjjnlkf 115 3 redundant redundant JJ cord-018103-czjjnlkf 115 4 sites site NNS cord-018103-czjjnlkf 115 5 , , , cord-018103-czjjnlkf 115 6 we -PRON- PRP cord-018103-czjjnlkf 115 7 obtained obtain VBD cord-018103-czjjnlkf 115 8 195 195 CD cord-018103-czjjnlkf 115 9 overlapping overlap VBG cord-018103-czjjnlkf 115 10 regions region NNS cord-018103-czjjnlkf 115 11 . . . cord-018103-czjjnlkf 116 1 After after IN cord-018103-czjjnlkf 116 2 further further RB cord-018103-czjjnlkf 116 3 removing remove VBG cord-018103-czjjnlkf 116 4 heptameric heptameric NN cord-018103-czjjnlkf 116 5 sequences sequence NNS cord-018103-czjjnlkf 116 6 that that WDT cord-018103-czjjnlkf 116 7 were be VBD cord-018103-czjjnlkf 116 8 not not RB cord-018103-czjjnlkf 116 9 located locate VBN cord-018103-czjjnlkf 116 10 in in IN cord-018103-czjjnlkf 116 11 the the DT cord-018103-czjjnlkf 116 12 overlapping overlap VBG cord-018103-czjjnlkf 116 13 region region NN cord-018103-czjjnlkf 116 14 , , , cord-018103-czjjnlkf 116 15 66 66 CD cord-018103-czjjnlkf 116 16 sites site NNS cord-018103-czjjnlkf 116 17 remained remain VBD cord-018103-czjjnlkf 116 18 in in IN cord-018103-czjjnlkf 116 19 the the DT cord-018103-czjjnlkf 116 20 overlapping overlap VBG cord-018103-czjjnlkf 116 21 regions region NNS cord-018103-czjjnlkf 116 22 . . . cord-018103-czjjnlkf 117 1 Considering consider VBG cord-018103-czjjnlkf 117 2 the the DT cord-018103-czjjnlkf 117 3 gene gene NN cord-018103-czjjnlkf 117 4 length length NN cord-018103-czjjnlkf 117 5 , , , cord-018103-czjjnlkf 117 6 shape shape NN cord-018103-czjjnlkf 117 7 and and CC cord-018103-czjjnlkf 117 8 length length NN cord-018103-czjjnlkf 117 9 of of IN cord-018103-czjjnlkf 117 10 the the DT cord-018103-czjjnlkf 117 11 overlapping overlap VBG cord-018103-czjjnlkf 117 12 region region NN cord-018103-czjjnlkf 117 13 , , , cord-018103-czjjnlkf 117 14 11 11 CD cord-018103-czjjnlkf 117 15 frameshift frameshift NN cord-018103-czjjnlkf 117 16 sites site NNS cord-018103-czjjnlkf 117 17 including include VBG cord-018103-czjjnlkf 117 18 3 3 CD cord-018103-czjjnlkf 117 19 known know VBN cord-018103-czjjnlkf 117 20 sites site NNS cord-018103-czjjnlkf 117 21 were be VBD cord-018103-czjjnlkf 117 22 considered consider VBN cord-018103-czjjnlkf 117 23 significant significant JJ cord-018103-czjjnlkf 117 24 candidates candidate NNS cord-018103-czjjnlkf 117 25 . . . cord-018103-czjjnlkf 118 1 Table table NN cord-018103-czjjnlkf 118 2 1 1 CD cord-018103-czjjnlkf 118 3 shows show VBZ cord-018103-czjjnlkf 118 4 the the DT cord-018103-czjjnlkf 118 5 names name NNS cord-018103-czjjnlkf 118 6 of of IN cord-018103-czjjnlkf 118 7 overlapping overlap VBG cord-018103-czjjnlkf 118 8 genes gene NNS cord-018103-czjjnlkf 118 9 , , , cord-018103-czjjnlkf 118 10 the the DT cord-018103-czjjnlkf 118 11 locations location NNS cord-018103-czjjnlkf 118 12 of of IN cord-018103-czjjnlkf 118 13 the the DT cord-018103-czjjnlkf 118 14 slippery slippery JJ cord-018103-czjjnlkf 118 15 sites site NNS cord-018103-czjjnlkf 118 16 , , , cord-018103-czjjnlkf 118 17 slippery slippery JJ cord-018103-czjjnlkf 118 18 sequences sequence NNS cord-018103-czjjnlkf 118 19 and and CC cord-018103-czjjnlkf 118 20 number number NN cord-018103-czjjnlkf 118 21 of of IN cord-018103-czjjnlkf 118 22 overlapped overlap VBN cord-018103-czjjnlkf 118 23 nucleotides nucleotide NNS cord-018103-czjjnlkf 118 24 from from IN cord-018103-czjjnlkf 118 25 our -PRON- PRP$ cord-018103-czjjnlkf 118 26 analysis analysis NN cord-018103-czjjnlkf 118 27 . . . cord-018103-czjjnlkf 119 1 The the DT cord-018103-czjjnlkf 119 2 three three CD cord-018103-czjjnlkf 119 3 genes gene NNS cord-018103-czjjnlkf 119 4 , , , cord-018103-czjjnlkf 119 5 yi21_1-yi22_1 yi21_1-yi22_1 NN cord-018103-czjjnlkf 119 6 , , , cord-018103-czjjnlkf 119 7 yi21_5-yi22_5 yi21_5-yi22_5 UH cord-018103-czjjnlkf 119 8 , , , cord-018103-czjjnlkf 119 9 yi21_6-yi22_6 yi21_6-yi22_6 NNP cord-018103-czjjnlkf 119 10 , , , cord-018103-czjjnlkf 119 11 are be VBP cord-018103-czjjnlkf 119 12 known know VBN cord-018103-czjjnlkf 119 13 genes gene NNS cord-018103-czjjnlkf 119 14 expressed express VBN cord-018103-czjjnlkf 119 15 via via IN cord-018103-czjjnlkf 119 16 -1 -1 NNP cord-018103-czjjnlkf 119 17 Table table NN cord-018103-czjjnlkf 119 18 1 1 CD cord-018103-czjjnlkf 119 19 . . . cord-018103-czjjnlkf 120 1 The the DT cord-018103-czjjnlkf 120 2 predicted predict VBN cord-018103-czjjnlkf 120 3 frameshift frameshift NN cord-018103-czjjnlkf 120 4 sites site NNS cord-018103-czjjnlkf 120 5 in in IN cord-018103-czjjnlkf 120 6 the the DT cord-018103-czjjnlkf 120 7 E. E. NNP cord-018103-czjjnlkf 120 8 coli coli VBZ cord-018103-czjjnlkf 120 9 K K NNP cord-018103-czjjnlkf 120 10 12 12 CD cord-018103-czjjnlkf 120 11 genome genome NN cord-018103-czjjnlkf 120 12 sequence sequence NN cord-018103-czjjnlkf 120 13 . . . cord-018103-czjjnlkf 121 1 The the DT cord-018103-czjjnlkf 121 2 first first JJ cord-018103-czjjnlkf 121 3 threegenes threegene NNS cord-018103-czjjnlkf 121 4 marked mark VBN cord-018103-czjjnlkf 121 5 with with IN cord-018103-czjjnlkf 121 6 * * NFP cord-018103-czjjnlkf 121 7 symbol symbol NN cord-018103-czjjnlkf 122 1 are be VBP cord-018103-czjjnlkf 122 2 those those DT cord-018103-czjjnlkf 122 3 with with IN cord-018103-czjjnlkf 122 4 known know VBN cord-018103-czjjnlkf 122 5 frameshift frameshift NN cord-018103-czjjnlkf 122 6 sites site NNS cord-018103-czjjnlkf 122 7 . . . cord-018103-czjjnlkf 123 1 PK PK NNP cord-018103-czjjnlkf 123 2 represents represent VBZ cord-018103-czjjnlkf 123 3 a a DT cord-018103-czjjnlkf 123 4 pseudoknot pseudoknot NN cord-018103-czjjnlkf 123 5 . . . cord-018103-czjjnlkf 124 1 frameshifts frameshifts NNP cord-018103-czjjnlkf 124 2 . . . cord-018103-czjjnlkf 125 1 These these DT cord-018103-czjjnlkf 125 2 three three CD cord-018103-czjjnlkf 125 3 genes gene NNS cord-018103-czjjnlkf 125 4 and and CC cord-018103-czjjnlkf 125 5 insA_6-insB_6 insA_6-insB_6 NNS cord-018103-czjjnlkf 125 6 are be VBP cord-018103-czjjnlkf 125 7 insertion insertion NN cord-018103-czjjnlkf 125 8 sequences sequence NNS cord-018103-czjjnlkf 125 9 . . . cord-018103-czjjnlkf 126 1 We -PRON- PRP cord-018103-czjjnlkf 126 2 believe believe VBP cord-018103-czjjnlkf 126 3 that that IN cord-018103-czjjnlkf 126 4 entB entB NNP cord-018103-czjjnlkf 126 5 - - HYPH cord-018103-czjjnlkf 126 6 entA enta NN cord-018103-czjjnlkf 126 7 , , , cord-018103-czjjnlkf 126 8 tehA tehA NNS cord-018103-czjjnlkf 126 9 - - HYPH cord-018103-czjjnlkf 126 10 tehB tehb CD cord-018103-czjjnlkf 126 11 , , , cord-018103-czjjnlkf 126 12 and and CC cord-018103-czjjnlkf 126 13 xdhB xdhB NNP cord-018103-czjjnlkf 126 14 - - : cord-018103-czjjnlkf 126 15 xdhC xdhc NN cord-018103-czjjnlkf 126 16 have have VBP cord-018103-czjjnlkf 126 17 a a DT cord-018103-czjjnlkf 126 18 high high JJ cord-018103-czjjnlkf 126 19 probability probability NN cord-018103-czjjnlkf 126 20 using use VBG cord-018103-czjjnlkf 126 21 frameshift frameshift NN cord-018103-czjjnlkf 126 22 events event NNS cord-018103-czjjnlkf 126 23 . . . cord-018103-czjjnlkf 127 1 All all PDT cord-018103-czjjnlkf 127 2 these these DT cord-018103-czjjnlkf 127 3 seven seven CD cord-018103-czjjnlkf 127 4 genes gene NNS cord-018103-czjjnlkf 127 5 have have VBP cord-018103-czjjnlkf 127 6 either either CC cord-018103-czjjnlkf 127 7 pseudoknot pseudoknot NN cord-018103-czjjnlkf 127 8 or or CC cord-018103-czjjnlkf 127 9 stem stem VB cord-018103-czjjnlkf 127 10 loop loop NN cord-018103-czjjnlkf 127 11 as as IN cord-018103-czjjnlkf 127 12 a a DT cord-018103-czjjnlkf 127 13 downstream downstream JJ cord-018103-czjjnlkf 127 14 secondary secondary JJ cord-018103-czjjnlkf 127 15 structure structure NN cord-018103-czjjnlkf 127 16 . . . cord-018103-czjjnlkf 128 1 The the DT cord-018103-czjjnlkf 128 2 rest rest NN cord-018103-czjjnlkf 128 3 four four CD cord-018103-czjjnlkf 128 4 genes gene NNS cord-018103-czjjnlkf 128 5 , , , cord-018103-czjjnlkf 128 6 mhpD mhpD NNPS cord-018103-czjjnlkf 128 7 - - HYPH cord-018103-czjjnlkf 128 8 mhpF mhpf JJ cord-018103-czjjnlkf 128 9 , , , cord-018103-czjjnlkf 128 10 fliM fliM NNS cord-018103-czjjnlkf 128 11 - - HYPH cord-018103-czjjnlkf 128 12 fliN flin CD cord-018103-czjjnlkf 128 13 , , , cord-018103-czjjnlkf 128 14 atoS atos NN cord-018103-czjjnlkf 128 15 - - HYPH cord-018103-czjjnlkf 128 16 atoC atoc NN cord-018103-czjjnlkf 128 17 and and CC cord-018103-czjjnlkf 128 18 yijC yijC NNP cord-018103-czjjnlkf 128 19 - - HYPH cord-018103-czjjnlkf 128 20 yijD yijD NNP cord-018103-czjjnlkf 128 21 , , , cord-018103-czjjnlkf 128 22 have have VBP cord-018103-czjjnlkf 128 23 no no DT cord-018103-czjjnlkf 128 24 downstream downstream JJ cord-018103-czjjnlkf 128 25 secondary secondary JJ cord-018103-czjjnlkf 128 26 structures structure NNS cord-018103-czjjnlkf 128 27 and and CC cord-018103-czjjnlkf 128 28 have have VBP cord-018103-czjjnlkf 128 29 a a DT cord-018103-czjjnlkf 128 30 lower low JJR cord-018103-czjjnlkf 128 31 probability probability NN cord-018103-czjjnlkf 128 32 of of IN cord-018103-czjjnlkf 128 33 frameshifting frameshifte VBG cord-018103-czjjnlkf 128 34 than than IN cord-018103-czjjnlkf 128 35 the the DT cord-018103-czjjnlkf 128 36 other other JJ cord-018103-czjjnlkf 128 37 7 7 CD cord-018103-czjjnlkf 128 38 genes gene NNS cord-018103-czjjnlkf 128 39 . . . cord-018103-czjjnlkf 129 1 There there EX cord-018103-czjjnlkf 129 2 exist exist VBP cord-018103-czjjnlkf 129 3 previous previous JJ cord-018103-czjjnlkf 129 4 works work NNS cord-018103-czjjnlkf 129 5 similar similar JJ cord-018103-czjjnlkf 129 6 to to IN cord-018103-czjjnlkf 129 7 our -PRON- PRP$ cord-018103-czjjnlkf 129 8 approach approach NN cord-018103-czjjnlkf 129 9 . . . cord-018103-czjjnlkf 130 1 Hammell Hammell NNP cord-018103-czjjnlkf 130 2 et et FW cord-018103-czjjnlkf 130 3 al al NNP cord-018103-czjjnlkf 130 4 . . . cord-018103-czjjnlkf 131 1 [ [ -LRB- cord-018103-czjjnlkf 131 2 7 7 CD cord-018103-czjjnlkf 131 3 ] ] -RRB- cord-018103-czjjnlkf 131 4 studied study VBN cord-018103-czjjnlkf 131 5 -1 -1 NN cord-018103-czjjnlkf 131 6 ribosomal ribosomal JJ cord-018103-czjjnlkf 131 7 frameshift frameshift NN cord-018103-czjjnlkf 131 8 signals signal NNS cord-018103-czjjnlkf 131 9 in in IN cord-018103-czjjnlkf 131 10 the the DT cord-018103-czjjnlkf 131 11 large large JJ cord-018103-czjjnlkf 131 12 databases database NNS cord-018103-czjjnlkf 131 13 . . . cord-018103-czjjnlkf 132 1 Using use VBG cord-018103-czjjnlkf 132 2 their -PRON- PRP$ cord-018103-czjjnlkf 132 3 well well RB cord-018103-czjjnlkf 132 4 - - HYPH cord-018103-czjjnlkf 132 5 established establish VBN cord-018103-czjjnlkf 132 6 model model NN cord-018103-czjjnlkf 132 7 , , , cord-018103-czjjnlkf 132 8 they -PRON- PRP cord-018103-czjjnlkf 132 9 found find VBD cord-018103-czjjnlkf 132 10 that that IN cord-018103-czjjnlkf 132 11 -1 -1 NNP cord-018103-czjjnlkf 132 12 frameshifts frameshift NNS cord-018103-czjjnlkf 132 13 occur occur VBP cord-018103-czjjnlkf 132 14 with with IN cord-018103-czjjnlkf 132 15 frequencies frequency NNS cord-018103-czjjnlkf 132 16 from from IN cord-018103-czjjnlkf 132 17 two two CD cord-018103-czjjnlkf 132 18 - - HYPH cord-018103-czjjnlkf 132 19 to to TO cord-018103-czjjnlkf 132 20 six six CD cord-018103-czjjnlkf 132 21 - - RB cord-018103-czjjnlkf 132 22 fold fold RB cord-018103-czjjnlkf 132 23 greater great JJR cord-018103-czjjnlkf 132 24 than than IN cord-018103-czjjnlkf 132 25 random random JJ cord-018103-czjjnlkf 132 26 . . . cord-018103-czjjnlkf 133 1 They -PRON- PRP cord-018103-czjjnlkf 133 2 considered consider VBD cord-018103-czjjnlkf 133 3 the the DT cord-018103-czjjnlkf 133 4 nucleotides nucleotide NNS cord-018103-czjjnlkf 133 5 of of IN cord-018103-czjjnlkf 133 6 a a DT cord-018103-czjjnlkf 133 7 frameshift frameshift NN cord-018103-czjjnlkf 133 8 site site NN cord-018103-czjjnlkf 133 9 , , , cord-018103-czjjnlkf 133 10 spacer spacer NN cord-018103-czjjnlkf 133 11 , , , cord-018103-czjjnlkf 133 12 and and CC cord-018103-czjjnlkf 133 13 pseudoknot pseudoknot NNP cord-018103-czjjnlkf 133 14 . . . cord-018103-czjjnlkf 134 1 However however RB cord-018103-czjjnlkf 134 2 , , , cord-018103-czjjnlkf 134 3 they -PRON- PRP cord-018103-czjjnlkf 134 4 focused focus VBD cord-018103-czjjnlkf 134 5 on on IN cord-018103-czjjnlkf 134 6 the the DT cord-018103-czjjnlkf 134 7 -1 -1 NNP cord-018103-czjjnlkf 134 8 frameshifts frameshifts NNP cord-018103-czjjnlkf 134 9 only only RB cord-018103-czjjnlkf 134 10 . . . cord-018103-czjjnlkf 135 1 Bekaert Bekaert NNP cord-018103-czjjnlkf 135 2 et et NNP cord-018103-czjjnlkf 135 3 al al NNP cord-018103-czjjnlkf 135 4 . . . cord-018103-czjjnlkf 136 1 [ [ -LRB- cord-018103-czjjnlkf 136 2 6 6 CD cord-018103-czjjnlkf 136 3 ] ] -RRB- cord-018103-czjjnlkf 136 4 performed perform VBD cord-018103-czjjnlkf 136 5 a a DT cord-018103-czjjnlkf 136 6 computational computational JJ cord-018103-czjjnlkf 136 7 method method NN cord-018103-czjjnlkf 136 8 similar similar JJ cord-018103-czjjnlkf 136 9 to to IN cord-018103-czjjnlkf 136 10 Hammell Hammell NNP cord-018103-czjjnlkf 136 11 's 's POS cord-018103-czjjnlkf 136 12 approach approach NN cord-018103-czjjnlkf 136 13 . . . cord-018103-czjjnlkf 137 1 From from IN cord-018103-czjjnlkf 137 2 their -PRON- PRP$ cord-018103-czjjnlkf 137 3 model model NN cord-018103-czjjnlkf 137 4 , , , cord-018103-czjjnlkf 137 5 they -PRON- PRP cord-018103-czjjnlkf 137 6 designed design VBD cord-018103-czjjnlkf 137 7 a a DT cord-018103-czjjnlkf 137 8 model model NN cord-018103-czjjnlkf 137 9 for for IN cord-018103-czjjnlkf 137 10 -1 -1 CD cord-018103-czjjnlkf 137 11 eukaryotic eukaryotic JJ cord-018103-czjjnlkf 137 12 frameshifting frameshifting NN cord-018103-czjjnlkf 137 13 . . . cord-018103-czjjnlkf 138 1 But but CC cord-018103-czjjnlkf 138 2 these these DT cord-018103-czjjnlkf 138 3 two two CD cord-018103-czjjnlkf 138 4 programs program NNS cord-018103-czjjnlkf 138 5 are be VBP cord-018103-czjjnlkf 138 6 not not RB cord-018103-czjjnlkf 138 7 available available JJ cord-018103-czjjnlkf 138 8 for for IN cord-018103-czjjnlkf 138 9 public public JJ cord-018103-czjjnlkf 138 10 use use NN cord-018103-czjjnlkf 138 11 . . . cord-018103-czjjnlkf 139 1 The the DT cord-018103-czjjnlkf 139 2 FreqAnalysis FreqAnalysis NNP cord-018103-czjjnlkf 139 3 [ [ -LRB- cord-018103-czjjnlkf 139 4 9 9 CD cord-018103-czjjnlkf 139 5 ] ] -RRB- cord-018103-czjjnlkf 139 6 is be VBZ cord-018103-czjjnlkf 139 7 an an DT cord-018103-czjjnlkf 139 8 application application NN cord-018103-czjjnlkf 139 9 program program NN cord-018103-czjjnlkf 139 10 available available JJ cord-018103-czjjnlkf 139 11 for for IN cord-018103-czjjnlkf 139 12 public public JJ cord-018103-czjjnlkf 139 13 use use NN cord-018103-czjjnlkf 139 14 . . . cord-018103-czjjnlkf 140 1 FreqAnalysis FreqAnalysis NNP cord-018103-czjjnlkf 140 2 was be VBD cord-018103-czjjnlkf 140 3 implemented implement VBN cord-018103-czjjnlkf 140 4 in in IN cord-018103-czjjnlkf 140 5 the the DT cord-018103-czjjnlkf 140 6 Java Java NNP cord-018103-czjjnlkf 140 7 language language NN cord-018103-czjjnlkf 140 8 and and CC cord-018103-czjjnlkf 140 9 can can MD cord-018103-czjjnlkf 140 10 find find VB cord-018103-czjjnlkf 140 11 putative putative JJ cord-018103-czjjnlkf 140 12 translational translational JJ cord-018103-czjjnlkf 140 13 frameshift frameshift NN cord-018103-czjjnlkf 140 14 from from IN cord-018103-czjjnlkf 140 15 probabilistic probabilistic JJ cord-018103-czjjnlkf 140 16 calculation calculation NN cord-018103-czjjnlkf 140 17 . . . cord-018103-czjjnlkf 141 1 In in IN cord-018103-czjjnlkf 141 2 fact fact NN cord-018103-czjjnlkf 141 3 , , , cord-018103-czjjnlkf 141 4 Shah Shah NNP cord-018103-czjjnlkf 141 5 et et NNP cord-018103-czjjnlkf 141 6 al al NNP cord-018103-czjjnlkf 141 7 . . . cord-018103-czjjnlkf 142 1 [ [ -LRB- cord-018103-czjjnlkf 142 2 9 9 CD cord-018103-czjjnlkf 142 3 ] ] -RRB- cord-018103-czjjnlkf 142 4 found find VBD cord-018103-czjjnlkf 142 5 putative putative JJ cord-018103-czjjnlkf 142 6 frameshift frameshift NN cord-018103-czjjnlkf 142 7 sites site NNS cord-018103-czjjnlkf 142 8 from from IN cord-018103-czjjnlkf 142 9 the the DT cord-018103-czjjnlkf 142 10 Sacharomyces Sacharomyces NNP cord-018103-czjjnlkf 142 11 cerevisiae cerevisiae NNS cord-018103-czjjnlkf 142 12 ORFs orfs NN cord-018103-czjjnlkf 142 13 . . . cord-018103-czjjnlkf 143 1 But but CC cord-018103-czjjnlkf 143 2 FreqAnalysis FreqAnalysis NNP cord-018103-czjjnlkf 143 3 does do VBZ cord-018103-czjjnlkf 143 4 not not RB cord-018103-czjjnlkf 143 5 consider consider VB cord-018103-czjjnlkf 143 6 the the DT cord-018103-czjjnlkf 143 7 X x NN cord-018103-czjjnlkf 143 8 XXY XXY NNP cord-018103-czjjnlkf 143 9 YYZ YYZ NNP cord-018103-czjjnlkf 143 10 frameshift frameshift NN cord-018103-czjjnlkf 143 11 motif motif NN cord-018103-czjjnlkf 143 12 . . . cord-018103-czjjnlkf 144 1 Thus thus RB cord-018103-czjjnlkf 144 2 it -PRON- PRP cord-018103-czjjnlkf 144 3 is be VBZ cord-018103-czjjnlkf 144 4 hard hard JJ cord-018103-czjjnlkf 144 5 to to TO cord-018103-czjjnlkf 144 6 compare compare VB cord-018103-czjjnlkf 144 7 the the DT cord-018103-czjjnlkf 144 8 results result NNS cord-018103-czjjnlkf 144 9 of of IN cord-018103-czjjnlkf 144 10 FreqAnalysis FreqAnalysis NNP cord-018103-czjjnlkf 144 11 with with IN cord-018103-czjjnlkf 144 12 ours our NNS cord-018103-czjjnlkf 144 13 directly directly RB cord-018103-czjjnlkf 144 14 . . . cord-018103-czjjnlkf 145 1 Fig Fig NNP cord-018103-czjjnlkf 145 2 . . NNP cord-018103-czjjnlkf 145 3 7 7 CD cord-018103-czjjnlkf 145 4 shows show VBZ cord-018103-czjjnlkf 145 5 the the DT cord-018103-czjjnlkf 145 6 result result NN cord-018103-czjjnlkf 145 7 of of IN cord-018103-czjjnlkf 145 8 the the DT cord-018103-czjjnlkf 145 9 FSFinder2 FSFinder2 NNP cord-018103-czjjnlkf 145 10 . . . cord-018103-czjjnlkf 146 1 Two two CD cord-018103-czjjnlkf 146 2 rectangles rectangle NNS cord-018103-czjjnlkf 146 3 filled fill VBN cord-018103-czjjnlkf 146 4 with with IN cord-018103-czjjnlkf 146 5 sky sky NN cord-018103-czjjnlkf 146 6 blue blue JJ cord-018103-czjjnlkf 146 7 color color NN cord-018103-czjjnlkf 146 8 in in IN cord-018103-czjjnlkf 146 9 the the DT cord-018103-czjjnlkf 146 10 upper upper JJ cord-018103-czjjnlkf 146 11 window window NN cord-018103-czjjnlkf 146 12 represent represent VBP cord-018103-czjjnlkf 146 13 i21_1 i21_1 NNS cord-018103-czjjnlkf 146 14 and and CC cord-018103-czjjnlkf 146 15 yi22_1 yi22_1 CD cord-018103-czjjnlkf 146 16 , , , cord-018103-czjjnlkf 146 17 respectively respectively RB cord-018103-czjjnlkf 146 18 . . . cord-018103-czjjnlkf 147 1 The the DT cord-018103-czjjnlkf 147 2 i21_1 i21_1 NN cord-018103-czjjnlkf 147 3 gene gene NN cord-018103-czjjnlkf 147 4 located locate VBN cord-018103-czjjnlkf 147 5 in in IN cord-018103-czjjnlkf 147 6 0 0 CD cord-018103-czjjnlkf 147 7 frame frame NN cord-018103-czjjnlkf 147 8 and and CC cord-018103-czjjnlkf 147 9 the the DT cord-018103-czjjnlkf 147 10 yi22_1 yi22_1 CD cord-018103-czjjnlkf 147 11 gene gene NN cord-018103-czjjnlkf 147 12 located locate VBN cord-018103-czjjnlkf 147 13 in in IN cord-018103-czjjnlkf 147 14 -1 -1 JJ cord-018103-czjjnlkf 147 15 frame frame NN cord-018103-czjjnlkf 147 16 are be VBP cord-018103-czjjnlkf 147 17 partially partially RB cord-018103-czjjnlkf 147 18 overlapped overlap VBN cord-018103-czjjnlkf 147 19 . . . cord-018103-czjjnlkf 148 1 When when WRB cord-018103-czjjnlkf 148 2 translational translational JJ cord-018103-czjjnlkf 148 3 frameshift frameshift NN cord-018103-czjjnlkf 148 4 occurs occur VBZ cord-018103-czjjnlkf 148 5 , , , cord-018103-czjjnlkf 148 6 translation translation NN cord-018103-czjjnlkf 148 7 continues continue VBZ cord-018103-czjjnlkf 148 8 past past IN cord-018103-czjjnlkf 148 9 the the DT cord-018103-czjjnlkf 148 10 stop stop NN cord-018103-czjjnlkf 148 11 codon codon NN cord-018103-czjjnlkf 148 12 at at IN cord-018103-czjjnlkf 148 13 380,938 380,938 CD cord-018103-czjjnlkf 148 14 until until IN cord-018103-czjjnlkf 148 15 the the DT cord-018103-czjjnlkf 148 16 stop stop NN cord-018103-czjjnlkf 148 17 codon codon NN cord-018103-czjjnlkf 148 18 at at IN cord-018103-czjjnlkf 148 19 381,801 381,801 CD cord-018103-czjjnlkf 148 20 . . . cord-018103-czjjnlkf 149 1 Ribosomal Ribosomal NNP cord-018103-czjjnlkf 149 2 frameshifting frameshifte VBG cord-018103-czjjnlkf 149 3 is be VBZ cord-018103-czjjnlkf 149 4 unusual unusual JJ cord-018103-czjjnlkf 149 5 event event NN cord-018103-czjjnlkf 149 6 which which WDT cord-018103-czjjnlkf 149 7 is be VBZ cord-018103-czjjnlkf 149 8 known know VBN cord-018103-czjjnlkf 149 9 to to TO cord-018103-czjjnlkf 149 10 affect affect VB cord-018103-czjjnlkf 149 11 producing produce VBG cord-018103-czjjnlkf 149 12 heterogeneous heterogeneous JJ cord-018103-czjjnlkf 149 13 proteins protein NNS cord-018103-czjjnlkf 149 14 , , , cord-018103-czjjnlkf 149 15 auto auto NN cord-018103-czjjnlkf 149 16 - - HYPH cord-018103-czjjnlkf 149 17 regulation regulation NN cord-018103-czjjnlkf 149 18 . . . cord-018103-czjjnlkf 150 1 Prediction prediction NN cord-018103-czjjnlkf 150 2 of of IN cord-018103-czjjnlkf 150 3 frameshift frameshift NN cord-018103-czjjnlkf 150 4 sites site NNS cord-018103-czjjnlkf 150 5 is be VBZ cord-018103-czjjnlkf 150 6 very very RB cord-018103-czjjnlkf 150 7 difficult difficult JJ cord-018103-czjjnlkf 150 8 . . . cord-018103-czjjnlkf 151 1 On on IN cord-018103-czjjnlkf 151 2 the the DT cord-018103-czjjnlkf 151 3 other other JJ cord-018103-czjjnlkf 151 4 hand hand NN cord-018103-czjjnlkf 151 5 if if IN cord-018103-czjjnlkf 151 6 prediction prediction NN cord-018103-czjjnlkf 151 7 is be VBZ cord-018103-czjjnlkf 151 8 possible possible JJ cord-018103-czjjnlkf 151 9 , , , cord-018103-czjjnlkf 151 10 this this DT cord-018103-czjjnlkf 151 11 is be VBZ cord-018103-czjjnlkf 151 12 very very RB cord-018103-czjjnlkf 151 13 useful useful JJ cord-018103-czjjnlkf 151 14 to to TO cord-018103-czjjnlkf 151 15 understand understand VB cord-018103-czjjnlkf 151 16 of of IN cord-018103-czjjnlkf 151 17 biological biological JJ cord-018103-czjjnlkf 151 18 phenomenon phenomenon NN cord-018103-czjjnlkf 151 19 . . . cord-018103-czjjnlkf 152 1 And and CC cord-018103-czjjnlkf 152 2 unveiling unveil VBG cord-018103-czjjnlkf 152 3 of of IN cord-018103-czjjnlkf 152 4 unknown unknown JJ cord-018103-czjjnlkf 152 5 protein protein NN cord-018103-czjjnlkf 152 6 production production NN cord-018103-czjjnlkf 152 7 mechanisms mechanism NNS cord-018103-czjjnlkf 152 8 can can MD cord-018103-czjjnlkf 152 9 be be VB cord-018103-czjjnlkf 152 10 realized realize VBN cord-018103-czjjnlkf 152 11 . . . cord-018103-czjjnlkf 153 1 For for IN cord-018103-czjjnlkf 153 2 this this DT cord-018103-czjjnlkf 153 3 valuable valuable JJ cord-018103-czjjnlkf 153 4 advantage advantage NN cord-018103-czjjnlkf 153 5 , , , cord-018103-czjjnlkf 153 6 we -PRON- PRP cord-018103-czjjnlkf 153 7 develop develop VBP cord-018103-czjjnlkf 153 8 a a DT cord-018103-czjjnlkf 153 9 web web NN cord-018103-czjjnlkf 153 10 application application NN cord-018103-czjjnlkf 153 11 and and CC cord-018103-czjjnlkf 153 12 serve serve VB cord-018103-czjjnlkf 153 13 web web NN cord-018103-czjjnlkf 153 14 service service NN cord-018103-czjjnlkf 153 15 for for IN cord-018103-czjjnlkf 153 16 prediction prediction NN cord-018103-czjjnlkf 153 17 of of IN cord-018103-czjjnlkf 153 18 frameshift frameshift NN cord-018103-czjjnlkf 153 19 sites site NNS cord-018103-czjjnlkf 153 20 . . . cord-018103-czjjnlkf 154 1 Using use VBG cord-018103-czjjnlkf 154 2 the the DT cord-018103-czjjnlkf 154 3 FSFinder FSFinder NNPS cord-018103-czjjnlkf 154 4 , , , cord-018103-czjjnlkf 154 5 we -PRON- PRP cord-018103-czjjnlkf 154 6 analyzed analyze VBD cord-018103-czjjnlkf 154 7 Escherichia Escherichia NNP cord-018103-czjjnlkf 154 8 coli coli VBZ cord-018103-czjjnlkf 154 9 K K NNP cord-018103-czjjnlkf 154 10 12 12 CD cord-018103-czjjnlkf 154 11 genome genome NN cord-018103-czjjnlkf 154 12 sequence sequence NN cord-018103-czjjnlkf 154 13 to to TO cord-018103-czjjnlkf 154 14 detect detect VB cord-018103-czjjnlkf 154 15 potential potential JJ cord-018103-czjjnlkf 154 16 -1 -1 NN cord-018103-czjjnlkf 154 17 frameshifting frameshifting JJ cord-018103-czjjnlkf 154 18 genes gene NNS cord-018103-czjjnlkf 154 19 . . . cord-018103-czjjnlkf 155 1 From from IN cord-018103-czjjnlkf 155 2 the the DT cord-018103-czjjnlkf 155 3 E. E. NNP cord-018103-czjjnlkf 155 4 coli coli VBZ cord-018103-czjjnlkf 155 5 K K NNP cord-018103-czjjnlkf 155 6 12 12 CD cord-018103-czjjnlkf 155 7 genome genome NN cord-018103-czjjnlkf 155 8 sequence sequence NN cord-018103-czjjnlkf 155 9 , , , cord-018103-czjjnlkf 155 10 we -PRON- PRP cord-018103-czjjnlkf 155 11 have have VBP cord-018103-czjjnlkf 155 12 got get VBN cord-018103-czjjnlkf 155 13 18,401 18,401 CD cord-018103-czjjnlkf 155 14 frameshift frameshift NN cord-018103-czjjnlkf 155 15 sites site NNS cord-018103-czjjnlkf 155 16 followed follow VBD cord-018103-czjjnlkf 155 17 X X NNP cord-018103-czjjnlkf 155 18 XXY XXY NNP cord-018103-czjjnlkf 155 19 YYZ YYZ NNP cord-018103-czjjnlkf 155 20 motif motif NN cord-018103-czjjnlkf 155 21 . . . cord-018103-czjjnlkf 156 1 Among among IN cord-018103-czjjnlkf 156 2 these these DT cord-018103-czjjnlkf 156 3 sequences sequence NNS cord-018103-czjjnlkf 156 4 , , , cord-018103-czjjnlkf 156 5 11,530 11,530 CD cord-018103-czjjnlkf 156 6 frameshift frameshift NN cord-018103-czjjnlkf 156 7 sites site NNS cord-018103-czjjnlkf 156 8 included include VBD cord-018103-czjjnlkf 156 9 secondary secondary JJ cord-018103-czjjnlkf 156 10 structure structure NN cord-018103-czjjnlkf 156 11 . . . cord-018103-czjjnlkf 157 1 Comparing compare VBG cord-018103-czjjnlkf 157 2 with with IN cord-018103-czjjnlkf 157 3 GenBank GenBank NNP cord-018103-czjjnlkf 157 4 description description NN cord-018103-czjjnlkf 157 5 , , , cord-018103-czjjnlkf 157 6 we -PRON- PRP cord-018103-czjjnlkf 157 7 have have VBP cord-018103-czjjnlkf 157 8 got get VBN cord-018103-czjjnlkf 157 9 11 11 CD cord-018103-czjjnlkf 157 10 sequences sequence NNS cord-018103-czjjnlkf 157 11 including include VBG cord-018103-czjjnlkf 157 12 3 3 CD cord-018103-czjjnlkf 157 13 known know VBN cord-018103-czjjnlkf 157 14 frameshift frameshift NN cord-018103-czjjnlkf 157 15 sites site NNS cord-018103-czjjnlkf 157 16 . . . cord-018103-czjjnlkf 158 1 Among among IN cord-018103-czjjnlkf 158 2 these these DT cord-018103-czjjnlkf 158 3 sequences sequence NNS cord-018103-czjjnlkf 158 4 , , , cord-018103-czjjnlkf 158 5 we -PRON- PRP cord-018103-czjjnlkf 158 6 believe believe VBP cord-018103-czjjnlkf 158 7 that that IN cord-018103-czjjnlkf 158 8 at at RB cord-018103-czjjnlkf 158 9 least least JJS cord-018103-czjjnlkf 158 10 4 4 CD cord-018103-czjjnlkf 158 11 sequences sequence NNS cord-018103-czjjnlkf 158 12 have have VBP cord-018103-czjjnlkf 158 13 a a DT cord-018103-czjjnlkf 158 14 high high JJ cord-018103-czjjnlkf 158 15 probability probability NN cord-018103-czjjnlkf 158 16 to to TO cord-018103-czjjnlkf 158 17 use use VB cord-018103-czjjnlkf 158 18 frameshift frameshift NN cord-018103-czjjnlkf 158 19 event event NN cord-018103-czjjnlkf 158 20 and and CC cord-018103-czjjnlkf 158 21 all all PDT cord-018103-czjjnlkf 158 22 these these DT cord-018103-czjjnlkf 158 23 4 4 CD cord-018103-czjjnlkf 158 24 sites site NNS cord-018103-czjjnlkf 158 25 have have VBP cord-018103-czjjnlkf 158 26 a a DT cord-018103-czjjnlkf 158 27 downstream downstream JJ cord-018103-czjjnlkf 158 28 secondary secondary JJ cord-018103-czjjnlkf 158 29 structure structure NN cord-018103-czjjnlkf 158 30 such such JJ cord-018103-czjjnlkf 158 31 as as IN cord-018103-czjjnlkf 158 32 pseudoknot pseudoknot NN cord-018103-czjjnlkf 158 33 and and CC cord-018103-czjjnlkf 158 34 stem stem VB cord-018103-czjjnlkf 158 35 loops loop NNS cord-018103-czjjnlkf 158 36 . . . cord-018103-czjjnlkf 159 1 Other other JJ cord-018103-czjjnlkf 159 2 4 4 CD cord-018103-czjjnlkf 159 3 gene gene NN cord-018103-czjjnlkf 159 4 do do VBP cord-018103-czjjnlkf 159 5 not not RB cord-018103-czjjnlkf 159 6 have have VB cord-018103-czjjnlkf 159 7 downstream downstream JJ cord-018103-czjjnlkf 159 8 structure structure NN cord-018103-czjjnlkf 159 9 , , , cord-018103-czjjnlkf 159 10 but but CC cord-018103-czjjnlkf 159 11 we -PRON- PRP cord-018103-czjjnlkf 159 12 believe believe VBP cord-018103-czjjnlkf 159 13 that that IN cord-018103-czjjnlkf 159 14 these these DT cord-018103-czjjnlkf 159 15 sequences sequence NNS cord-018103-czjjnlkf 159 16 have have VBP cord-018103-czjjnlkf 159 17 less less JJR cord-018103-czjjnlkf 159 18 probabilities probability NNS cord-018103-czjjnlkf 159 19 than than IN cord-018103-czjjnlkf 159 20 above above IN cord-018103-czjjnlkf 159 21 7 7 CD cord-018103-czjjnlkf 159 22 genes gene NNS cord-018103-czjjnlkf 159 23 but but CC cord-018103-czjjnlkf 159 24 significant significant JJ cord-018103-czjjnlkf 159 25 . . . cord-018103-czjjnlkf 160 1 Programmed program VBN cord-018103-czjjnlkf 160 2 Translational Translational NNP cord-018103-czjjnlkf 160 3 Frameshifting Frameshifting NNP cord-018103-czjjnlkf 160 4 Recoding recoding NN cord-018103-czjjnlkf 160 5 : : : cord-018103-czjjnlkf 160 6 Dynamic dynamic JJ cord-018103-czjjnlkf 160 7 Reprogramming reprogramming NN cord-018103-czjjnlkf 160 8 of of IN cord-018103-czjjnlkf 161 1 Translation translation NN cord-018103-czjjnlkf 161 2 One one CD cord-018103-czjjnlkf 161 3 Protein protein NN cord-018103-czjjnlkf 161 4 From from IN cord-018103-czjjnlkf 161 5 Two two CD cord-018103-czjjnlkf 161 6 Open open JJ cord-018103-czjjnlkf 161 7 Reading reading NN cord-018103-czjjnlkf 161 8 Frames frame NNS cord-018103-czjjnlkf 161 9 : : : cord-018103-czjjnlkf 161 10 Mechanism mechanism NN cord-018103-czjjnlkf 161 11 of of IN cord-018103-czjjnlkf 161 12 a a DT cord-018103-czjjnlkf 161 13 50 50 CD cord-018103-czjjnlkf 161 14 ntTranslational ntTranslational NNP cord-018103-czjjnlkf 161 15 Bypass Bypass NNP cord-018103-czjjnlkf 161 16 Recoding Recoding NNP cord-018103-czjjnlkf 161 17 : : : cord-018103-czjjnlkf 161 18 Translational Translational NNP cord-018103-czjjnlkf 161 19 Bifurcations Bifurcations NNPS cord-018103-czjjnlkf 161 20 in in IN cord-018103-czjjnlkf 161 21 Gene Gene NNP cord-018103-czjjnlkf 161 22 Expression Expression NNP cord-018103-czjjnlkf 162 1 Predicting predict VBG cord-018103-czjjnlkf 162 2 Genes Genes NNPS cord-018103-czjjnlkf 162 3 Expressed express VBN cord-018103-czjjnlkf 162 4 via via IN cord-018103-czjjnlkf 162 5 -1 -1 CD cord-018103-czjjnlkf 162 6 and and CC cord-018103-czjjnlkf 162 7 +1 +1 NFP cord-018103-czjjnlkf 162 8 Frameshifts Frameshifts NNP cord-018103-czjjnlkf 162 9 Towards towards IN cord-018103-czjjnlkf 162 10 a a DT cord-018103-czjjnlkf 162 11 Computational Computational NNP cord-018103-czjjnlkf 162 12 Model Model NNP cord-018103-czjjnlkf 162 13 for for IN cord-018103-czjjnlkf 162 14 -1 -1 NNP cord-018103-czjjnlkf 163 1 Eukaryotic Eukaryotic NNP cord-018103-czjjnlkf 163 2 Frameshifting Frameshifting NNP cord-018103-czjjnlkf 163 3 Sites Sites NNPS cord-018103-czjjnlkf 163 4 Identification Identification NNP cord-018103-czjjnlkf 163 5 of of IN cord-018103-czjjnlkf 163 6 Putative Putative NNP cord-018103-czjjnlkf 163 7 Programmed Programmed NNP cord-018103-czjjnlkf 163 8 -1 -1 . cord-018103-czjjnlkf 164 1 Ribosomal Ribosomal NNP cord-018103-czjjnlkf 164 2 Frameshift Frameshift NNP cord-018103-czjjnlkf 164 3 Signals Signals NNPS cord-018103-czjjnlkf 164 4 in in IN cord-018103-czjjnlkf 164 5 Large large JJ cord-018103-czjjnlkf 164 6 DNA dna NN cord-018103-czjjnlkf 164 7 Databases database NNS cord-018103-czjjnlkf 164 8 Programmed program VBN cord-018103-czjjnlkf 164 9 -1 -1 . cord-018103-czjjnlkf 165 1 Ribosomal Ribosomal NNP cord-018103-czjjnlkf 165 2 Frameshifting Frameshifting NNP cord-018103-czjjnlkf 165 3 in in IN cord-018103-czjjnlkf 165 4 the the DT cord-018103-czjjnlkf 165 5 SARS SARS NNP cord-018103-czjjnlkf 165 6 Coronavirus Coronavirus NNP cord-018103-czjjnlkf 165 7 Computational Computational NNP cord-018103-czjjnlkf 165 8 Identification Identification NNP cord-018103-czjjnlkf 165 9 of of IN cord-018103-czjjnlkf 165 10 Putative Putative NNP cord-018103-czjjnlkf 165 11 Programmed program VBN cord-018103-czjjnlkf 165 12 Translational Translational NNP cord-018103-czjjnlkf 165 13 Frameshift Frameshift NNP cord-018103-czjjnlkf 165 14 Sites Sites NNPS cord-018103-czjjnlkf 165 15 . . . cord-018103-czjjnlkf 166 1 Bioinformatics bioinformatic NNS