key: cord-278424-ifdftckx
authors: Hsu, David T.; Jarcho, Johanna M.
title: “Next up for psychiatry: rejection sensitivity and the social brain”
date: 2020-08-13
journal: Neuropsychopharmacology
DOI: 10.1038/s41386-020-00802-9
sha: 
doc_id: 278424
cord_uid: ifdftckx

nan

Indeed, we have shown greater differences in neural response to peer acceptance and rejection in socially anxious early adolescents relative to older adolescents [5] and adults [6] . Widespread isolation due to COVID-19 is an opportunity to track these changes and push the field of social neuroscience forward.

Reducing rejection sensitivity may be a novel and effective treatment strategy. Neurotransmitter systems involved in social cognition and behavior in animal models (e.g., opioid, oxytocin, vasopressin systems) have yet to be investigated for their role in rejection sensitivity and resilience in humans. Targeting these systems could break the vicious cycle of rejection and loneliness to accelerate recovery.

The authors have nothing to disclose. DTH was supported by R01 MH102264 and JMJ was supported by R21 HD093912.

The vicious circle of social exclusion and psychopathology: a systematic review of experimental ostracism research in psychiatric disorders. Eur Arch Psychiatry Clin Neurosci

It still hurts: altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder

Dissociable neural responses to monetary and social gain and loss in women with major depressive disorder

I Knew you weren't going to like me! neural response to accurately predicting rejection is associated with anxiety and depression

Social anxiety and age are associated with neural response to social evaluation during adolescence

Forgetting the best when predicting the worst: preliminary observations on neural circuit function in adolescent social anxiety

The authors would like to thank Asha Job, MD, for discussions and feedback on this article.

DTH and JMJ wrote the article.

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