id sid tid token lemma pos cord-312840-jvdph782 1 1 key key NN cord-312840-jvdph782 1 2 : : : cord-312840-jvdph782 1 3 cord-312840-jvdph782 cord-312840-jvdph782 NNP cord-312840-jvdph782 1 4 authors author NNS cord-312840-jvdph782 1 5 : : : cord-312840-jvdph782 1 6 White White NNP cord-312840-jvdph782 1 7 , , , cord-312840-jvdph782 1 8 Laura Laura NNP cord-312840-jvdph782 1 9 F F NNP cord-312840-jvdph782 1 10 ; ; : cord-312840-jvdph782 1 11 Archer Archer NNP cord-312840-jvdph782 1 12 , , , cord-312840-jvdph782 1 13 Brett Brett NNP cord-312840-jvdph782 1 14 ; ; : cord-312840-jvdph782 1 15 Pagano Pagano NNP cord-312840-jvdph782 1 16 , , , cord-312840-jvdph782 1 17 Marcello Marcello NNP cord-312840-jvdph782 1 18 title title NN cord-312840-jvdph782 1 19 : : : cord-312840-jvdph782 1 20 Determining determine VBG cord-312840-jvdph782 1 21 the the DT cord-312840-jvdph782 1 22 dynamics dynamic NNS cord-312840-jvdph782 1 23 of of IN cord-312840-jvdph782 1 24 influenza influenza NN cord-312840-jvdph782 1 25 transmission transmission NN cord-312840-jvdph782 1 26 by by IN cord-312840-jvdph782 1 27 age age NN cord-312840-jvdph782 1 28 date date NN cord-312840-jvdph782 1 29 : : : cord-312840-jvdph782 1 30 2014 2014 CD cord-312840-jvdph782 1 31 - - HYPH cord-312840-jvdph782 1 32 03 03 CD cord-312840-jvdph782 1 33 - - SYM cord-312840-jvdph782 1 34 21 21 CD cord-312840-jvdph782 1 35 journal journal NN cord-312840-jvdph782 1 36 : : : cord-312840-jvdph782 1 37 Emerg Emerg NNP cord-312840-jvdph782 1 38 Themes Themes NNP cord-312840-jvdph782 1 39 Epidemiol Epidemiol NNP cord-312840-jvdph782 1 40 DOI doi NN cord-312840-jvdph782 1 41 : : : cord-312840-jvdph782 1 42 10.1186/1742 10.1186/1742 CD cord-312840-jvdph782 1 43 - - HYPH cord-312840-jvdph782 1 44 7622 7622 CD cord-312840-jvdph782 1 45 - - HYPH cord-312840-jvdph782 1 46 11 11 CD cord-312840-jvdph782 1 47 - - SYM cord-312840-jvdph782 1 48 4 4 CD cord-312840-jvdph782 1 49 sha sha NNP cord-312840-jvdph782 1 50 : : : cord-312840-jvdph782 1 51 491f229f1a4bc9fb8f4c85097040666e5ad1c455 491f229f1a4bc9fb8f4c85097040666e5ad1c455 CD cord-312840-jvdph782 1 52 doc_id doc_id CD cord-312840-jvdph782 1 53 : : : cord-312840-jvdph782 1 54 312840 312840 CD cord-312840-jvdph782 1 55 cord_uid cord_uid NNS cord-312840-jvdph782 1 56 : : : cord-312840-jvdph782 2 1 jvdph782 jvdph782 NNP cord-312840-jvdph782 2 2 BACKGROUND BACKGROUND NNP cord-312840-jvdph782 2 3 : : : cord-312840-jvdph782 3 1 It -PRON- PRP cord-312840-jvdph782 3 2 is be VBZ cord-312840-jvdph782 3 3 widely widely RB cord-312840-jvdph782 3 4 accepted accept VBN cord-312840-jvdph782 3 5 that that IN cord-312840-jvdph782 3 6 influenza influenza NN cord-312840-jvdph782 3 7 transmission transmission NN cord-312840-jvdph782 3 8 dynamics dynamic NNS cord-312840-jvdph782 3 9 vary vary VBP cord-312840-jvdph782 3 10 by by IN cord-312840-jvdph782 3 11 age age NN cord-312840-jvdph782 3 12 ; ; : cord-312840-jvdph782 3 13 however however RB cord-312840-jvdph782 3 14 methods method NNS cord-312840-jvdph782 3 15 to to TO cord-312840-jvdph782 3 16 quantify quantify VB cord-312840-jvdph782 3 17 the the DT cord-312840-jvdph782 3 18 reproductive reproductive JJ cord-312840-jvdph782 3 19 number number NN cord-312840-jvdph782 3 20 by by IN cord-312840-jvdph782 3 21 age age NN cord-312840-jvdph782 3 22 group group NN cord-312840-jvdph782 3 23 are be VBP cord-312840-jvdph782 3 24 limited limited JJ cord-312840-jvdph782 3 25 . . . cord-312840-jvdph782 4 1 We -PRON- PRP cord-312840-jvdph782 4 2 introduce introduce VBP cord-312840-jvdph782 4 3 a a DT cord-312840-jvdph782 4 4 simple simple JJ cord-312840-jvdph782 4 5 method method NN cord-312840-jvdph782 4 6 to to TO cord-312840-jvdph782 4 7 estimate estimate VB cord-312840-jvdph782 4 8 the the DT cord-312840-jvdph782 4 9 reproductive reproductive JJ cord-312840-jvdph782 4 10 number number NN cord-312840-jvdph782 4 11 by by IN cord-312840-jvdph782 4 12 modifying modify VBG cord-312840-jvdph782 4 13 the the DT cord-312840-jvdph782 4 14 method method NN cord-312840-jvdph782 4 15 originally originally RB cord-312840-jvdph782 4 16 proposed propose VBN cord-312840-jvdph782 4 17 by by IN cord-312840-jvdph782 4 18 Wallinga Wallinga NNP cord-312840-jvdph782 4 19 and and CC cord-312840-jvdph782 4 20 Teunis Teunis NNP cord-312840-jvdph782 4 21 and and CC cord-312840-jvdph782 4 22 using use VBG cord-312840-jvdph782 4 23 existing exist VBG cord-312840-jvdph782 4 24 information information NN cord-312840-jvdph782 4 25 on on IN cord-312840-jvdph782 4 26 contact contact NN cord-312840-jvdph782 4 27 patterns pattern NNS cord-312840-jvdph782 4 28 between between IN cord-312840-jvdph782 4 29 age age NN cord-312840-jvdph782 4 30 groups group NNS cord-312840-jvdph782 4 31 . . . cord-312840-jvdph782 5 1 We -PRON- PRP cord-312840-jvdph782 5 2 additionally additionally RB cord-312840-jvdph782 5 3 perform perform VBP cord-312840-jvdph782 5 4 a a DT cord-312840-jvdph782 5 5 sensitivity sensitivity NN cord-312840-jvdph782 5 6 analysis analysis NN cord-312840-jvdph782 5 7 to to TO cord-312840-jvdph782 5 8 determine determine VB cord-312840-jvdph782 5 9 the the DT cord-312840-jvdph782 5 10 potential potential JJ cord-312840-jvdph782 5 11 impact impact NN cord-312840-jvdph782 5 12 of of IN cord-312840-jvdph782 5 13 differential differential JJ cord-312840-jvdph782 5 14 healthcare healthcare NN cord-312840-jvdph782 5 15 seeking seek VBG cord-312840-jvdph782 5 16 patterns pattern NNS cord-312840-jvdph782 5 17 by by IN cord-312840-jvdph782 5 18 age age NN cord-312840-jvdph782 5 19 . . . cord-312840-jvdph782 6 1 We -PRON- PRP cord-312840-jvdph782 6 2 illustrate illustrate VBP cord-312840-jvdph782 6 3 this this DT cord-312840-jvdph782 6 4 method method NN cord-312840-jvdph782 6 5 using use VBG cord-312840-jvdph782 6 6 data datum NNS cord-312840-jvdph782 6 7 from from IN cord-312840-jvdph782 6 8 the the DT cord-312840-jvdph782 6 9 2009 2009 CD cord-312840-jvdph782 6 10 H1N1 H1N1 NNP cord-312840-jvdph782 6 11 Influenza Influenza NNP cord-312840-jvdph782 6 12 pandemic pandemic NN cord-312840-jvdph782 6 13 in in IN cord-312840-jvdph782 6 14 Gauteng Gauteng NNP cord-312840-jvdph782 6 15 Province Province NNP cord-312840-jvdph782 6 16 , , , cord-312840-jvdph782 6 17 South South NNP cord-312840-jvdph782 6 18 Africa Africa NNP cord-312840-jvdph782 6 19 . . . cord-312840-jvdph782 7 1 RESULTS result NNS cord-312840-jvdph782 7 2 : : : cord-312840-jvdph782 8 1 Our -PRON- PRP$ cord-312840-jvdph782 8 2 results result NNS cord-312840-jvdph782 8 3 are be VBP cord-312840-jvdph782 8 4 consistent consistent JJ cord-312840-jvdph782 8 5 with with IN cord-312840-jvdph782 8 6 others other NNS cord-312840-jvdph782 8 7 in in IN cord-312840-jvdph782 8 8 showing show VBG cord-312840-jvdph782 8 9 decreased decrease VBN cord-312840-jvdph782 8 10 transmission transmission NN cord-312840-jvdph782 8 11 with with IN cord-312840-jvdph782 8 12 age age NN cord-312840-jvdph782 8 13 . . . cord-312840-jvdph782 9 1 We -PRON- PRP cord-312840-jvdph782 9 2 show show VBP cord-312840-jvdph782 9 3 that that IN cord-312840-jvdph782 9 4 results result NNS cord-312840-jvdph782 9 5 can can MD cord-312840-jvdph782 9 6 change change VB cord-312840-jvdph782 9 7 markedly markedly RB cord-312840-jvdph782 9 8 when when WRB cord-312840-jvdph782 9 9 we -PRON- PRP cord-312840-jvdph782 9 10 make make VBP cord-312840-jvdph782 9 11 the the DT cord-312840-jvdph782 9 12 account account NN cord-312840-jvdph782 9 13 for for IN cord-312840-jvdph782 9 14 differential differential JJ cord-312840-jvdph782 9 15 healthcare healthcare NN cord-312840-jvdph782 9 16 seeking seek VBG cord-312840-jvdph782 9 17 behaviors behavior NNS cord-312840-jvdph782 9 18 by by IN cord-312840-jvdph782 9 19 age age NN cord-312840-jvdph782 9 20 . . . cord-312840-jvdph782 10 1 CONCLUSIONS conclusion NNS cord-312840-jvdph782 10 2 : : : cord-312840-jvdph782 11 1 We -PRON- PRP cord-312840-jvdph782 11 2 show show VBP cord-312840-jvdph782 11 3 substantial substantial JJ cord-312840-jvdph782 11 4 heterogeneity heterogeneity NN cord-312840-jvdph782 11 5 in in IN cord-312840-jvdph782 11 6 transmission transmission NN cord-312840-jvdph782 11 7 by by IN cord-312840-jvdph782 11 8 age age NN cord-312840-jvdph782 11 9 group group NN cord-312840-jvdph782 11 10 during during IN cord-312840-jvdph782 11 11 the the DT cord-312840-jvdph782 11 12 Influenza Influenza NNP cord-312840-jvdph782 11 13 A a DT cord-312840-jvdph782 11 14 H1N1 H1N1 NNP cord-312840-jvdph782 11 15 pandemic pandemic NN cord-312840-jvdph782 11 16 in in IN cord-312840-jvdph782 11 17 South South NNP cord-312840-jvdph782 11 18 Africa Africa NNP cord-312840-jvdph782 11 19 . . . cord-312840-jvdph782 12 1 This this DT cord-312840-jvdph782 12 2 information information NN cord-312840-jvdph782 12 3 can can MD cord-312840-jvdph782 12 4 greatly greatly RB cord-312840-jvdph782 12 5 assist assist VB cord-312840-jvdph782 12 6 in in IN cord-312840-jvdph782 12 7 targeting target VBG cord-312840-jvdph782 12 8 interventions intervention NNS cord-312840-jvdph782 12 9 and and CC cord-312840-jvdph782 12 10 implementing implement VBG cord-312840-jvdph782 12 11 social social JJ cord-312840-jvdph782 12 12 distancing distance VBG cord-312840-jvdph782 12 13 measures measure NNS cord-312840-jvdph782 12 14 . . . cord-312840-jvdph782 13 1 The the DT cord-312840-jvdph782 13 2 importance importance NN cord-312840-jvdph782 13 3 of of IN cord-312840-jvdph782 13 4 the the DT cord-312840-jvdph782 13 5 dynamics dynamic NNS cord-312840-jvdph782 13 6 of of IN cord-312840-jvdph782 13 7 influenza influenza NN cord-312840-jvdph782 13 8 transmission transmission NN cord-312840-jvdph782 13 9 between between IN cord-312840-jvdph782 13 10 age age NN cord-312840-jvdph782 13 11 groups group NNS cord-312840-jvdph782 13 12 is be VBZ cord-312840-jvdph782 13 13 well well RB cord-312840-jvdph782 13 14 - - HYPH cord-312840-jvdph782 13 15 appreciated appreciate VBN cord-312840-jvdph782 13 16 [ [ -LRB- cord-312840-jvdph782 13 17 1 1 CD cord-312840-jvdph782 13 18 ] ] -RRB- cord-312840-jvdph782 13 19 [ [ -LRB- cord-312840-jvdph782 13 20 2 2 CD cord-312840-jvdph782 13 21 ] ] -RRB- cord-312840-jvdph782 13 22 [ [ -LRB- cord-312840-jvdph782 13 23 3 3 CD cord-312840-jvdph782 13 24 ] ] -RRB- cord-312840-jvdph782 13 25 [ [ -LRB- cord-312840-jvdph782 13 26 4 4 CD cord-312840-jvdph782 13 27 ] ] -RRB- cord-312840-jvdph782 13 28 [ [ -LRB- cord-312840-jvdph782 13 29 5 5 CD cord-312840-jvdph782 13 30 ] ] -RRB- cord-312840-jvdph782 13 31 [ [ -LRB- cord-312840-jvdph782 13 32 6 6 CD cord-312840-jvdph782 13 33 ] ] -RRB- cord-312840-jvdph782 13 34 . . . cord-312840-jvdph782 14 1 Several several JJ cord-312840-jvdph782 14 2 studies study NNS cord-312840-jvdph782 14 3 have have VBP cord-312840-jvdph782 14 4 assessed assess VBN cord-312840-jvdph782 14 5 the the DT cord-312840-jvdph782 14 6 non non JJ cord-312840-jvdph782 14 7 - - JJ cord-312840-jvdph782 14 8 uniformity uniformity NN cord-312840-jvdph782 14 9 of of IN cord-312840-jvdph782 14 10 the the DT cord-312840-jvdph782 14 11 impact impact NN cord-312840-jvdph782 14 12 of of IN cord-312840-jvdph782 14 13 influenza influenza NN cord-312840-jvdph782 14 14 , , , cord-312840-jvdph782 14 15 particularly particularly RB cord-312840-jvdph782 14 16 pandemic pandemic JJ cord-312840-jvdph782 14 17 influenza influenza NN cord-312840-jvdph782 14 18 , , , cord-312840-jvdph782 14 19 on on IN cord-312840-jvdph782 14 20 different different JJ cord-312840-jvdph782 14 21 age age NN cord-312840-jvdph782 14 22 groups group NNS cord-312840-jvdph782 14 23 [ [ -LRB- cord-312840-jvdph782 14 24 1 1 CD cord-312840-jvdph782 14 25 ] ] -RRB- cord-312840-jvdph782 14 26 [ [ -LRB- cord-312840-jvdph782 14 27 2 2 CD cord-312840-jvdph782 14 28 ] ] -RRB- cord-312840-jvdph782 14 29 [ [ -LRB- cord-312840-jvdph782 14 30 3 3 CD cord-312840-jvdph782 14 31 ] ] -RRB- cord-312840-jvdph782 14 32 [ [ -LRB- cord-312840-jvdph782 14 33 4 4 CD cord-312840-jvdph782 14 34 ] ] -RRB- cord-312840-jvdph782 14 35 [ [ -LRB- cord-312840-jvdph782 14 36 7 7 CD cord-312840-jvdph782 14 37 ] ] -RRB- cord-312840-jvdph782 15 1 [ [ -LRB- cord-312840-jvdph782 15 2 8 8 CD cord-312840-jvdph782 15 3 ] ] -RRB- cord-312840-jvdph782 15 4 [ [ -LRB- cord-312840-jvdph782 15 5 9 9 CD cord-312840-jvdph782 15 6 ] ] -RRB- cord-312840-jvdph782 15 7 . . . cord-312840-jvdph782 16 1 The the DT cord-312840-jvdph782 16 2 overarching overarching JJ cord-312840-jvdph782 16 3 interest interest NN cord-312840-jvdph782 16 4 in in IN cord-312840-jvdph782 16 5 these these DT cord-312840-jvdph782 16 6 studies study NNS cord-312840-jvdph782 16 7 is be VBZ cord-312840-jvdph782 16 8 to to TO cord-312840-jvdph782 16 9 gather gather VB cord-312840-jvdph782 16 10 information information NN cord-312840-jvdph782 16 11 in in IN cord-312840-jvdph782 16 12 order order NN cord-312840-jvdph782 16 13 to to TO cord-312840-jvdph782 16 14 influence influence VB cord-312840-jvdph782 16 15 policy policy NN cord-312840-jvdph782 16 16 to to IN cord-312840-jvdph782 16 17 best good JJS cord-312840-jvdph782 16 18 determine determine VB cord-312840-jvdph782 16 19 a a DT cord-312840-jvdph782 16 20 strategy strategy NN cord-312840-jvdph782 16 21 to to TO cord-312840-jvdph782 16 22 impact impact VB cord-312840-jvdph782 16 23 on on IN cord-312840-jvdph782 16 24 the the DT cord-312840-jvdph782 16 25 spread spread NN cord-312840-jvdph782 16 26 of of IN cord-312840-jvdph782 16 27 outbreaks outbreak NNS cord-312840-jvdph782 16 28 . . . cord-312840-jvdph782 17 1 Which which WDT cord-312840-jvdph782 17 2 age age NN cord-312840-jvdph782 17 3 groups group NNS cord-312840-jvdph782 17 4 carry carry VBP cord-312840-jvdph782 17 5 the the DT cord-312840-jvdph782 17 6 greatest great JJS cord-312840-jvdph782 17 7 disease disease NN cord-312840-jvdph782 17 8 burden burden NN cord-312840-jvdph782 17 9 and and CC cord-312840-jvdph782 17 10 which which WDT cord-312840-jvdph782 17 11 groups group NNS cord-312840-jvdph782 17 12 are be VBP cord-312840-jvdph782 17 13 responsible responsible JJ cord-312840-jvdph782 17 14 for for IN cord-312840-jvdph782 17 15 the the DT cord-312840-jvdph782 17 16 greatest great JJS cord-312840-jvdph782 17 17 amount amount NN cord-312840-jvdph782 17 18 of of IN cord-312840-jvdph782 17 19 disease disease NN cord-312840-jvdph782 17 20 transmission transmission NN cord-312840-jvdph782 17 21 is be VBZ cord-312840-jvdph782 17 22 an an DT cord-312840-jvdph782 17 23 important important JJ cord-312840-jvdph782 17 24 component component NN cord-312840-jvdph782 17 25 of of IN cord-312840-jvdph782 17 26 this this DT cord-312840-jvdph782 17 27 information information NN cord-312840-jvdph782 17 28 . . . cord-312840-jvdph782 18 1 One one CD cord-312840-jvdph782 18 2 key key JJ cord-312840-jvdph782 18 3 aspect aspect NN cord-312840-jvdph782 18 4 of of IN cord-312840-jvdph782 18 5 this this DT cord-312840-jvdph782 18 6 work work NN cord-312840-jvdph782 18 7 is be VBZ cord-312840-jvdph782 18 8 to to TO cord-312840-jvdph782 18 9 estimate estimate VB cord-312840-jvdph782 18 10 the the DT cord-312840-jvdph782 18 11 extent extent NN cord-312840-jvdph782 18 12 to to TO cord-312840-jvdph782 18 13 which which WDT cord-312840-jvdph782 18 14 people people NNS cord-312840-jvdph782 18 15 in in IN cord-312840-jvdph782 18 16 different different JJ cord-312840-jvdph782 18 17 age age NN cord-312840-jvdph782 18 18 groups group NNS cord-312840-jvdph782 18 19 interact interact VBP cord-312840-jvdph782 18 20 with with IN cord-312840-jvdph782 18 21 one one CD cord-312840-jvdph782 18 22 another another DT cord-312840-jvdph782 18 23 and and CC cord-312840-jvdph782 18 24 to to IN cord-312840-jvdph782 18 25 what what WDT cord-312840-jvdph782 18 26 degree degree NN cord-312840-jvdph782 18 27 they -PRON- PRP cord-312840-jvdph782 18 28 are be VBP cord-312840-jvdph782 18 29 in in IN cord-312840-jvdph782 18 30 contact contact NN cord-312840-jvdph782 18 31 . . . cord-312840-jvdph782 19 1 This this DT cord-312840-jvdph782 19 2 information information NN cord-312840-jvdph782 19 3 can can MD cord-312840-jvdph782 19 4 then then RB cord-312840-jvdph782 19 5 be be VB cord-312840-jvdph782 19 6 used use VBN cord-312840-jvdph782 19 7 as as IN cord-312840-jvdph782 19 8 a a DT cord-312840-jvdph782 19 9 surrogate surrogate NN cord-312840-jvdph782 19 10 for for IN cord-312840-jvdph782 19 11 transmission transmission NN cord-312840-jvdph782 19 12 probabilities probability NNS cord-312840-jvdph782 19 13 between between IN cord-312840-jvdph782 19 14 age age NN cord-312840-jvdph782 19 15 groups group NNS cord-312840-jvdph782 19 16 [ [ -LRB- cord-312840-jvdph782 19 17 10 10 CD cord-312840-jvdph782 19 18 ] ] -RRB- cord-312840-jvdph782 19 19 [ [ -LRB- cord-312840-jvdph782 19 20 11 11 CD cord-312840-jvdph782 19 21 ] ] -RRB- cord-312840-jvdph782 19 22 [ [ -LRB- cord-312840-jvdph782 19 23 12 12 CD cord-312840-jvdph782 19 24 ] ] -RRB- cord-312840-jvdph782 19 25 . . . cord-312840-jvdph782 20 1 Several several JJ cord-312840-jvdph782 20 2 studies study NNS cord-312840-jvdph782 20 3 have have VBP cord-312840-jvdph782 20 4 generated generate VBN cord-312840-jvdph782 20 5 matrices matrix NNS cord-312840-jvdph782 20 6 with with IN cord-312840-jvdph782 20 7 estimated estimate VBN cord-312840-jvdph782 20 8 numbers number NNS cord-312840-jvdph782 20 9 of of IN cord-312840-jvdph782 20 10 contacts contact NNS cord-312840-jvdph782 20 11 between between IN cord-312840-jvdph782 20 12 various various JJ cord-312840-jvdph782 20 13 age age NN cord-312840-jvdph782 20 14 groups group NNS cord-312840-jvdph782 20 15 [ [ -LRB- cord-312840-jvdph782 20 16 5 5 CD cord-312840-jvdph782 20 17 , , , cord-312840-jvdph782 20 18 12 12 CD cord-312840-jvdph782 20 19 , , , cord-312840-jvdph782 20 20 13 13 CD cord-312840-jvdph782 20 21 ] ] -RRB- cord-312840-jvdph782 20 22 . . . cord-312840-jvdph782 21 1 Additionally additionally RB cord-312840-jvdph782 21 2 , , , cord-312840-jvdph782 21 3 social social JJ cord-312840-jvdph782 21 4 network network NN cord-312840-jvdph782 21 5 models model NNS cord-312840-jvdph782 21 6 have have VBP cord-312840-jvdph782 21 7 been be VBN cord-312840-jvdph782 21 8 used use VBN cord-312840-jvdph782 21 9 to to TO cord-312840-jvdph782 21 10 estimate estimate VB cord-312840-jvdph782 21 11 these these DT cord-312840-jvdph782 21 12 contact contact NN cord-312840-jvdph782 21 13 patterns pattern NNS cord-312840-jvdph782 21 14 [ [ -LRB- cord-312840-jvdph782 21 15 7 7 CD cord-312840-jvdph782 21 16 ] ] -RRB- cord-312840-jvdph782 21 17 . . . cord-312840-jvdph782 22 1 A a DT cord-312840-jvdph782 22 2 common common JJ cord-312840-jvdph782 22 3 finding finding NN cord-312840-jvdph782 22 4 amongst amongst IN cord-312840-jvdph782 22 5 these these DT cord-312840-jvdph782 22 6 studies study NNS cord-312840-jvdph782 22 7 is be VBZ cord-312840-jvdph782 22 8 that that IN cord-312840-jvdph782 22 9 children child NNS cord-312840-jvdph782 22 10 tend tend VBP cord-312840-jvdph782 22 11 to to TO cord-312840-jvdph782 22 12 mix mix VB cord-312840-jvdph782 22 13 mostly mostly RB cord-312840-jvdph782 22 14 with with IN cord-312840-jvdph782 22 15 each each DT cord-312840-jvdph782 22 16 other other JJ cord-312840-jvdph782 22 17 , , , cord-312840-jvdph782 22 18 and and CC cord-312840-jvdph782 22 19 to to IN cord-312840-jvdph782 22 20 a a DT cord-312840-jvdph782 22 21 lesser less JJR cord-312840-jvdph782 22 22 extent extent NN cord-312840-jvdph782 22 23 with with IN cord-312840-jvdph782 22 24 their -PRON- PRP$ cord-312840-jvdph782 22 25 parents parent NNS cord-312840-jvdph782 22 26 , , , cord-312840-jvdph782 22 27 while while IN cord-312840-jvdph782 22 28 adults adult NNS cord-312840-jvdph782 22 29 mix mix VBP cord-312840-jvdph782 22 30 with with IN cord-312840-jvdph782 22 31 individuals individual NNS cord-312840-jvdph782 22 32 from from IN cord-312840-jvdph782 22 33 a a DT cord-312840-jvdph782 22 34 larger large JJR cord-312840-jvdph782 22 35 range range NN cord-312840-jvdph782 22 36 of of IN cord-312840-jvdph782 22 37 ages age NNS cord-312840-jvdph782 22 38 [ [ -LRB- cord-312840-jvdph782 22 39 5 5 CD cord-312840-jvdph782 22 40 , , , cord-312840-jvdph782 22 41 7 7 CD cord-312840-jvdph782 22 42 ] ] -RRB- cord-312840-jvdph782 22 43 . . . cord-312840-jvdph782 23 1 These these DT cord-312840-jvdph782 23 2 matrices matrix NNS cord-312840-jvdph782 23 3 have have VBP cord-312840-jvdph782 23 4 subsequently subsequently RB cord-312840-jvdph782 23 5 been be VBN cord-312840-jvdph782 23 6 used use VBN cord-312840-jvdph782 23 7 in in IN cord-312840-jvdph782 23 8 modeling model VBG cord-312840-jvdph782 23 9 exercises exercise NNS cord-312840-jvdph782 23 10 to to TO cord-312840-jvdph782 23 11 better better RB cord-312840-jvdph782 23 12 understand understand VB cord-312840-jvdph782 23 13 the the DT cord-312840-jvdph782 23 14 dynamics dynamic NNS cord-312840-jvdph782 23 15 of of IN cord-312840-jvdph782 23 16 disease disease NN cord-312840-jvdph782 23 17 spread spread VBN cord-312840-jvdph782 23 18 by by IN cord-312840-jvdph782 23 19 age age NN cord-312840-jvdph782 23 20 . . . cord-312840-jvdph782 24 1 When when WRB cord-312840-jvdph782 24 2 determining determine VBG cord-312840-jvdph782 24 3 which which WDT cord-312840-jvdph782 24 4 groups group NNS cord-312840-jvdph782 24 5 to to TO cord-312840-jvdph782 24 6 target target VB cord-312840-jvdph782 24 7 for for IN cord-312840-jvdph782 24 8 interventions intervention NNS cord-312840-jvdph782 24 9 in in IN cord-312840-jvdph782 24 10 an an DT cord-312840-jvdph782 24 11 outbreak outbreak NN cord-312840-jvdph782 24 12 , , , cord-312840-jvdph782 24 13 one one CD cord-312840-jvdph782 24 14 strategy strategy NN cord-312840-jvdph782 24 15 is be VBZ cord-312840-jvdph782 24 16 to to TO cord-312840-jvdph782 24 17 target target VB cord-312840-jvdph782 24 18 those those DT cord-312840-jvdph782 24 19 who who WP cord-312840-jvdph782 24 20 potentially potentially RB cord-312840-jvdph782 24 21 carry carry VBP cord-312840-jvdph782 24 22 the the DT cord-312840-jvdph782 24 23 greatest great JJS cord-312840-jvdph782 24 24 burden burden NN cord-312840-jvdph782 24 25 of of IN cord-312840-jvdph782 24 26 disease disease NN cord-312840-jvdph782 24 27 [ [ -LRB- cord-312840-jvdph782 24 28 14 14 CD cord-312840-jvdph782 24 29 ] ] -RRB- cord-312840-jvdph782 24 30 , , , cord-312840-jvdph782 24 31 which which WDT cord-312840-jvdph782 24 32 has have VBZ cord-312840-jvdph782 24 33 typically typically RB cord-312840-jvdph782 24 34 been be VBN cord-312840-jvdph782 24 35 found find VBN cord-312840-jvdph782 24 36 to to TO cord-312840-jvdph782 24 37 be be VB cord-312840-jvdph782 24 38 children child NNS cord-312840-jvdph782 24 39 [ [ -LRB- cord-312840-jvdph782 24 40 1 1 CD cord-312840-jvdph782 24 41 , , , cord-312840-jvdph782 24 42 5 5 CD cord-312840-jvdph782 24 43 , , , cord-312840-jvdph782 24 44 7 7 CD cord-312840-jvdph782 24 45 , , , cord-312840-jvdph782 24 46 8 8 CD cord-312840-jvdph782 24 47 , , , cord-312840-jvdph782 24 48 13 13 CD cord-312840-jvdph782 24 49 ] ] -RRB- cord-312840-jvdph782 24 50 . . . cord-312840-jvdph782 25 1 For for IN cord-312840-jvdph782 25 2 instance instance NN cord-312840-jvdph782 25 3 , , , cord-312840-jvdph782 25 4 Bansel Bansel NNP cord-312840-jvdph782 25 5 et et FW cord-312840-jvdph782 25 6 al al NNP cord-312840-jvdph782 25 7 . . . cord-312840-jvdph782 26 1 [ [ -LRB- cord-312840-jvdph782 26 2 4 4 LS cord-312840-jvdph782 26 3 ] ] -RRB- cord-312840-jvdph782 26 4 consider consider VB cord-312840-jvdph782 26 5 data datum NNS cord-312840-jvdph782 26 6 from from IN cord-312840-jvdph782 26 7 influenza influenza NN cord-312840-jvdph782 26 8 pandemics pandemic NNS cord-312840-jvdph782 26 9 over over IN cord-312840-jvdph782 26 10 the the DT cord-312840-jvdph782 26 11 past past JJ cord-312840-jvdph782 26 12 century century NN cord-312840-jvdph782 26 13 and and CC cord-312840-jvdph782 26 14 show show VB cord-312840-jvdph782 26 15 that that IN cord-312840-jvdph782 26 16 the the DT cord-312840-jvdph782 26 17 burden burden NN cord-312840-jvdph782 26 18 of of IN cord-312840-jvdph782 26 19 disease disease NN cord-312840-jvdph782 26 20 is be VBZ cord-312840-jvdph782 26 21 highest high JJS cord-312840-jvdph782 26 22 amongst amongst IN cord-312840-jvdph782 26 23 children child NNS cord-312840-jvdph782 26 24 during during IN cord-312840-jvdph782 26 25 a a DT cord-312840-jvdph782 26 26 pandemic pandemic NN cord-312840-jvdph782 26 27 and and CC cord-312840-jvdph782 26 28 then then RB cord-312840-jvdph782 26 29 shifts shift VBZ cord-312840-jvdph782 26 30 to to IN cord-312840-jvdph782 26 31 adults adult NNS cord-312840-jvdph782 26 32 the the DT cord-312840-jvdph782 26 33 following follow VBG cord-312840-jvdph782 26 34 season season NN cord-312840-jvdph782 26 35 . . . cord-312840-jvdph782 27 1 To to TO cord-312840-jvdph782 27 2 better well RBR cord-312840-jvdph782 27 3 understand understand VB cord-312840-jvdph782 27 4 the the DT cord-312840-jvdph782 27 5 utility utility NN cord-312840-jvdph782 27 6 of of IN cord-312840-jvdph782 27 7 targeting target VBG cord-312840-jvdph782 27 8 the the DT cord-312840-jvdph782 27 9 groups group NNS cord-312840-jvdph782 27 10 with with IN cord-312840-jvdph782 27 11 the the DT cord-312840-jvdph782 27 12 greatest great JJS cord-312840-jvdph782 27 13 burden burden NN cord-312840-jvdph782 27 14 of of IN cord-312840-jvdph782 27 15 disease disease NN cord-312840-jvdph782 27 16 , , , cord-312840-jvdph782 27 17 it -PRON- PRP cord-312840-jvdph782 27 18 is be VBZ cord-312840-jvdph782 27 19 also also RB cord-312840-jvdph782 27 20 important important JJ cord-312840-jvdph782 27 21 to to TO cord-312840-jvdph782 27 22 determine determine VB cord-312840-jvdph782 27 23 when when WRB cord-312840-jvdph782 27 24 different different JJ cord-312840-jvdph782 27 25 age age NN cord-312840-jvdph782 27 26 groups group NNS cord-312840-jvdph782 27 27 tend tend VBP cord-312840-jvdph782 27 28 to to TO cord-312840-jvdph782 27 29 have have VB cord-312840-jvdph782 27 30 their -PRON- PRP$ cord-312840-jvdph782 27 31 peak peak NN cord-312840-jvdph782 27 32 incidence incidence NN cord-312840-jvdph782 27 33 of of IN cord-312840-jvdph782 27 34 cases case NNS cord-312840-jvdph782 27 35 . . . cord-312840-jvdph782 28 1 This this DT cord-312840-jvdph782 28 2 can can MD cord-312840-jvdph782 28 3 also also RB cord-312840-jvdph782 28 4 be be VB cord-312840-jvdph782 28 5 seen see VBN cord-312840-jvdph782 28 6 as as IN cord-312840-jvdph782 28 7 a a DT cord-312840-jvdph782 28 8 surrogate surrogate JJ cord-312840-jvdph782 28 9 measure measure NN cord-312840-jvdph782 28 10 for for IN cord-312840-jvdph782 28 11 the the DT cord-312840-jvdph782 28 12 age age NN cord-312840-jvdph782 28 13 group group NN cord-312840-jvdph782 28 14 that that WDT cord-312840-jvdph782 28 15 is be VBZ cord-312840-jvdph782 28 16 driving drive VBG cord-312840-jvdph782 28 17 an an DT cord-312840-jvdph782 28 18 outbreak outbreak NN cord-312840-jvdph782 28 19 [ [ -LRB- cord-312840-jvdph782 28 20 15 15 CD cord-312840-jvdph782 28 21 ] ] -RRB- cord-312840-jvdph782 28 22 [ [ -LRB- cord-312840-jvdph782 28 23 16 16 CD cord-312840-jvdph782 28 24 ] ] -RRB- cord-312840-jvdph782 28 25 [ [ -LRB- cord-312840-jvdph782 28 26 17 17 CD cord-312840-jvdph782 28 27 ] ] -RRB- cord-312840-jvdph782 28 28 . . . cord-312840-jvdph782 29 1 Most most RBS cord-312840-jvdph782 29 2 recently recently RB cord-312840-jvdph782 29 3 Schanzer Schanzer NNP cord-312840-jvdph782 29 4 et et NNP cord-312840-jvdph782 29 5 al al NNP cord-312840-jvdph782 29 6 . . . cord-312840-jvdph782 30 1 [ [ -LRB- cord-312840-jvdph782 30 2 16 16 CD cord-312840-jvdph782 30 3 ] ] -RRB- cord-312840-jvdph782 30 4 used use VBN cord-312840-jvdph782 30 5 10 10 CD cord-312840-jvdph782 30 6 years year NNS cord-312840-jvdph782 30 7 of of IN cord-312840-jvdph782 30 8 Canadian canadian JJ cord-312840-jvdph782 30 9 surveillance surveillance NN cord-312840-jvdph782 30 10 data datum NNS cord-312840-jvdph782 30 11 of of IN cord-312840-jvdph782 30 12 laboratory laboratory NN cord-312840-jvdph782 30 13 confirmed confirm VBD cord-312840-jvdph782 30 14 cases case NNS cord-312840-jvdph782 30 15 of of IN cord-312840-jvdph782 30 16 influenza influenza NN cord-312840-jvdph782 30 17 and and CC cord-312840-jvdph782 30 18 found find VBD cord-312840-jvdph782 30 19 that that IN cord-312840-jvdph782 30 20 during during IN cord-312840-jvdph782 30 21 seasonal seasonal JJ cord-312840-jvdph782 30 22 influenza influenza NN cord-312840-jvdph782 30 23 the the DT cord-312840-jvdph782 30 24 10 10 CD cord-312840-jvdph782 30 25 - - SYM cord-312840-jvdph782 30 26 19 19 CD cord-312840-jvdph782 30 27 and and CC cord-312840-jvdph782 30 28 20 20 CD cord-312840-jvdph782 30 29 - - SYM cord-312840-jvdph782 30 30 29 29 CD cord-312840-jvdph782 30 31 year year NN cord-312840-jvdph782 30 32 - - HYPH cord-312840-jvdph782 30 33 old old JJ cord-312840-jvdph782 30 34 age age NN cord-312840-jvdph782 30 35 groups group NNS cord-312840-jvdph782 30 36 tended tend VBD cord-312840-jvdph782 30 37 to to TO cord-312840-jvdph782 30 38 peak peak VB cord-312840-jvdph782 30 39 one one CD cord-312840-jvdph782 30 40 week week NN cord-312840-jvdph782 30 41 earlier early RBR cord-312840-jvdph782 30 42 than than IN cord-312840-jvdph782 30 43 other other JJ cord-312840-jvdph782 30 44 groups group NNS cord-312840-jvdph782 30 45 . . . cord-312840-jvdph782 31 1 During during IN cord-312840-jvdph782 31 2 the the DT cord-312840-jvdph782 31 3 pandemic pandemic NN cord-312840-jvdph782 31 4 in in IN cord-312840-jvdph782 31 5 2009 2009 CD cord-312840-jvdph782 31 6 , , , cord-312840-jvdph782 31 7 the the DT cord-312840-jvdph782 31 8 peak peak NN cord-312840-jvdph782 31 9 came come VBD cord-312840-jvdph782 31 10 earliest early JJS cord-312840-jvdph782 31 11 for for IN cord-312840-jvdph782 31 12 only only RB cord-312840-jvdph782 31 13 the the DT cord-312840-jvdph782 31 14 10 10 CD cord-312840-jvdph782 31 15 - - SYM cord-312840-jvdph782 31 16 19 19 CD cord-312840-jvdph782 31 17 year year NN cord-312840-jvdph782 31 18 old old JJ cord-312840-jvdph782 31 19 age age NN cord-312840-jvdph782 31 20 group group NN cord-312840-jvdph782 31 21 . . . cord-312840-jvdph782 32 1 This this DT cord-312840-jvdph782 32 2 is be VBZ cord-312840-jvdph782 32 3 inconsistent inconsistent JJ cord-312840-jvdph782 32 4 with with IN cord-312840-jvdph782 32 5 the the DT cord-312840-jvdph782 32 6 findings finding NNS cord-312840-jvdph782 32 7 of of IN cord-312840-jvdph782 32 8 Brownstein Brownstein NNP cord-312840-jvdph782 32 9 et et NNP cord-312840-jvdph782 32 10 al al NNP cord-312840-jvdph782 32 11 . . . cord-312840-jvdph782 33 1 [ [ -LRB- cord-312840-jvdph782 33 2 15 15 CD cord-312840-jvdph782 33 3 ] ] -RRB- cord-312840-jvdph782 33 4 who who WP cord-312840-jvdph782 33 5 found find VBD cord-312840-jvdph782 33 6 that that IN cord-312840-jvdph782 33 7 children child NNS cord-312840-jvdph782 33 8 aged age VBN cord-312840-jvdph782 33 9 3 3 CD cord-312840-jvdph782 33 10 - - SYM cord-312840-jvdph782 33 11 4 4 CD cord-312840-jvdph782 33 12 were be VBD cord-312840-jvdph782 33 13 consistently consistently RB cord-312840-jvdph782 33 14 the the DT cord-312840-jvdph782 33 15 first first JJ cord-312840-jvdph782 33 16 to to TO cord-312840-jvdph782 33 17 peak peak VB cord-312840-jvdph782 33 18 . . . cord-312840-jvdph782 34 1 A a DT cord-312840-jvdph782 34 2 different different JJ cord-312840-jvdph782 34 3 tactic tactic NN cord-312840-jvdph782 34 4 for for IN cord-312840-jvdph782 34 5 determining determine VBG cord-312840-jvdph782 34 6 which which WDT cord-312840-jvdph782 34 7 groups group NNS cord-312840-jvdph782 34 8 should should MD cord-312840-jvdph782 34 9 be be VB cord-312840-jvdph782 34 10 the the DT cord-312840-jvdph782 34 11 target target NN cord-312840-jvdph782 34 12 of of IN cord-312840-jvdph782 34 13 interventions intervention NNS cord-312840-jvdph782 34 14 is be VBZ cord-312840-jvdph782 34 15 to to TO cord-312840-jvdph782 34 16 select select VB cord-312840-jvdph782 34 17 those those DT cord-312840-jvdph782 34 18 groups group NNS cord-312840-jvdph782 34 19 most most RBS cord-312840-jvdph782 34 20 responsible responsible JJ cord-312840-jvdph782 34 21 for for IN cord-312840-jvdph782 34 22 transmission transmission NN cord-312840-jvdph782 34 23 [ [ -LRB- cord-312840-jvdph782 34 24 18 18 CD cord-312840-jvdph782 34 25 ] ] -RRB- cord-312840-jvdph782 34 26 . . . cord-312840-jvdph782 35 1 Studies study NNS cord-312840-jvdph782 35 2 examining examine VBG cord-312840-jvdph782 35 3 disease disease NN cord-312840-jvdph782 35 4 transmission transmission NN cord-312840-jvdph782 35 5 by by IN cord-312840-jvdph782 35 6 age age NN cord-312840-jvdph782 35 7 have have VBP cord-312840-jvdph782 35 8 consistently consistently RB cord-312840-jvdph782 35 9 shown show VBN cord-312840-jvdph782 35 10 that that IN cord-312840-jvdph782 35 11 children child NNS cord-312840-jvdph782 35 12 have have VBP cord-312840-jvdph782 35 13 higher high JJR cord-312840-jvdph782 35 14 estimated estimate VBN cord-312840-jvdph782 35 15 values value NNS cord-312840-jvdph782 35 16 of of IN cord-312840-jvdph782 35 17 the the DT cord-312840-jvdph782 35 18 reproductive reproductive JJ cord-312840-jvdph782 35 19 number number NN cord-312840-jvdph782 35 20 than than IN cord-312840-jvdph782 35 21 adults adult NNS cord-312840-jvdph782 35 22 . . . cord-312840-jvdph782 36 1 Recent recent JJ cord-312840-jvdph782 36 2 work work NN cord-312840-jvdph782 36 3 has have VBZ cord-312840-jvdph782 36 4 focused focus VBN cord-312840-jvdph782 36 5 on on IN cord-312840-jvdph782 36 6 the the DT cord-312840-jvdph782 36 7 dynamics dynamic NNS cord-312840-jvdph782 36 8 during during IN cord-312840-jvdph782 36 9 the the DT cord-312840-jvdph782 36 10 2009 2009 CD cord-312840-jvdph782 36 11 Influenza Influenza NNP cord-312840-jvdph782 36 12 pandemic pandemic NN cord-312840-jvdph782 36 13 . . . cord-312840-jvdph782 37 1 During during IN cord-312840-jvdph782 37 2 the the DT cord-312840-jvdph782 37 3 initial initial JJ cord-312840-jvdph782 37 4 phase phase NN cord-312840-jvdph782 37 5 of of IN cord-312840-jvdph782 37 6 the the DT cord-312840-jvdph782 37 7 pandemic pandemic NN cord-312840-jvdph782 37 8 in in IN cord-312840-jvdph782 37 9 Japan Japan NNP cord-312840-jvdph782 37 10 , , , cord-312840-jvdph782 37 11 Nishiura Nishiura NNP cord-312840-jvdph782 37 12 et et NNP cord-312840-jvdph782 37 13 al al NNP cord-312840-jvdph782 37 14 . . . cord-312840-jvdph782 38 1 [ [ -LRB- cord-312840-jvdph782 38 2 19 19 CD cord-312840-jvdph782 38 3 ] ] -RRB- cord-312840-jvdph782 38 4 report report VBP cord-312840-jvdph782 38 5 that that IN cord-312840-jvdph782 38 6 children child NNS cord-312840-jvdph782 38 7 were be VBD cord-312840-jvdph782 38 8 transmitting transmit VBG cord-312840-jvdph782 38 9 illness illness NN cord-312840-jvdph782 38 10 at at IN cord-312840-jvdph782 38 11 higher high JJR cord-312840-jvdph782 38 12 rates rate NNS cord-312840-jvdph782 38 13 than than IN cord-312840-jvdph782 38 14 adults adult NNS cord-312840-jvdph782 38 15 . . . cord-312840-jvdph782 39 1 Glass Glass NNP cord-312840-jvdph782 39 2 et et FW cord-312840-jvdph782 39 3 al al NNP cord-312840-jvdph782 39 4 . . . cord-312840-jvdph782 40 1 [ [ -LRB- cord-312840-jvdph782 40 2 2 2 LS cord-312840-jvdph782 40 3 ] ] -RRB- cord-312840-jvdph782 40 4 used use VBN cord-312840-jvdph782 40 5 Japanese japanese JJ cord-312840-jvdph782 40 6 data datum NNS cord-312840-jvdph782 40 7 and and CC cord-312840-jvdph782 40 8 a a DT cord-312840-jvdph782 40 9 novel novel JJ cord-312840-jvdph782 40 10 method method NN cord-312840-jvdph782 40 11 to to TO cord-312840-jvdph782 40 12 estimate estimate VB cord-312840-jvdph782 40 13 the the DT cord-312840-jvdph782 40 14 reproductive reproductive JJ cord-312840-jvdph782 40 15 number number NN cord-312840-jvdph782 40 16 , , , cord-312840-jvdph782 40 17 R r NN cord-312840-jvdph782 40 18 0 0 CD cord-312840-jvdph782 40 19 , , , cord-312840-jvdph782 40 20 for for IN cord-312840-jvdph782 40 21 adults adult NNS cord-312840-jvdph782 40 22 and and CC cord-312840-jvdph782 40 23 children child NNS cord-312840-jvdph782 40 24 that that WDT cord-312840-jvdph782 40 25 assume assume VBP cord-312840-jvdph782 40 26 particular particular JJ cord-312840-jvdph782 40 27 forms form NNS cord-312840-jvdph782 40 28 for for IN cord-312840-jvdph782 40 29 a a DT cord-312840-jvdph782 40 30 nextgeneration nextgeneration NN cord-312840-jvdph782 40 31 matrix matrix NN cord-312840-jvdph782 40 32 and and CC cord-312840-jvdph782 40 33 estimate estimate VB cord-312840-jvdph782 40 34 the the DT cord-312840-jvdph782 40 35 parameters parameter NNS cord-312840-jvdph782 40 36 of of IN cord-312840-jvdph782 40 37 this this DT cord-312840-jvdph782 40 38 matrix matrix NN cord-312840-jvdph782 40 39 , , , cord-312840-jvdph782 40 40 leading lead VBG cord-312840-jvdph782 40 41 to to IN cord-312840-jvdph782 40 42 outbreak outbreak VB cord-312840-jvdph782 40 43 specific specific JJ cord-312840-jvdph782 40 44 estimates estimate NNS cord-312840-jvdph782 40 45 of of IN cord-312840-jvdph782 40 46 R r NN cord-312840-jvdph782 40 47 0 0 CD cord-312840-jvdph782 40 48 . . . cord-312840-jvdph782 41 1 They -PRON- PRP cord-312840-jvdph782 41 2 estimate estimate VBP cord-312840-jvdph782 41 3 R r NN cord-312840-jvdph782 41 4 0 0 CD cord-312840-jvdph782 41 5 to to TO cord-312840-jvdph782 41 6 be be VB cord-312840-jvdph782 41 7 between between IN cord-312840-jvdph782 41 8 2.8 2.8 CD cord-312840-jvdph782 41 9 and and CC cord-312840-jvdph782 41 10 3.6 3.6 CD cord-312840-jvdph782 41 11 for for IN cord-312840-jvdph782 41 12 children child NNS cord-312840-jvdph782 41 13 and and CC cord-312840-jvdph782 41 14 between between IN cord-312840-jvdph782 41 15 0.2 0.2 CD cord-312840-jvdph782 41 16 and and CC cord-312840-jvdph782 41 17 0.7 0.7 CD cord-312840-jvdph782 41 18 for for IN cord-312840-jvdph782 41 19 adults adult NNS cord-312840-jvdph782 41 20 , , , cord-312840-jvdph782 41 21 depending depend VBG cord-312840-jvdph782 41 22 on on IN cord-312840-jvdph782 41 23 the the DT cord-312840-jvdph782 41 24 assumptions assumption NNS cord-312840-jvdph782 41 25 made make VBN cord-312840-jvdph782 41 26 . . . cord-312840-jvdph782 42 1 In in IN cord-312840-jvdph782 42 2 a a DT cord-312840-jvdph782 42 3 later later JJ cord-312840-jvdph782 42 4 study study NN cord-312840-jvdph782 42 5 , , , cord-312840-jvdph782 42 6 Glass Glass NNP cord-312840-jvdph782 42 7 et et NNP cord-312840-jvdph782 42 8 al al NNP cord-312840-jvdph782 42 9 . . . cord-312840-jvdph782 43 1 [ [ -LRB- cord-312840-jvdph782 43 2 3 3 CD cord-312840-jvdph782 43 3 ] ] -RRB- cord-312840-jvdph782 43 4 used use VBN cord-312840-jvdph782 43 5 serosurvey serosurvey NNP cord-312840-jvdph782 43 6 data datum NNS cord-312840-jvdph782 43 7 and and CC cord-312840-jvdph782 43 8 estimate estimate NN cord-312840-jvdph782 43 9 R r NN cord-312840-jvdph782 43 10 0 0 CD cord-312840-jvdph782 43 11 from from IN cord-312840-jvdph782 43 12 the the DT cord-312840-jvdph782 43 13 final final JJ cord-312840-jvdph782 43 14 size size NN cord-312840-jvdph782 43 15 of of IN cord-312840-jvdph782 43 16 the the DT cord-312840-jvdph782 43 17 epidemic epidemic NN cord-312840-jvdph782 43 18 to to TO cord-312840-jvdph782 43 19 be be VB cord-312840-jvdph782 43 20 1.6 1.6 CD cord-312840-jvdph782 43 21 for for IN cord-312840-jvdph782 43 22 kids kid NNS cord-312840-jvdph782 43 23 and and CC cord-312840-jvdph782 43 24 less less JJR cord-312840-jvdph782 43 25 than than IN cord-312840-jvdph782 43 26 1 1 CD cord-312840-jvdph782 43 27 for for IN cord-312840-jvdph782 43 28 adults adult NNS cord-312840-jvdph782 43 29 . . . cord-312840-jvdph782 44 1 Wallinga Wallinga NNP cord-312840-jvdph782 44 2 et et NNP cord-312840-jvdph782 44 3 al al NNP cord-312840-jvdph782 44 4 . . . cord-312840-jvdph782 45 1 [ [ -LRB- cord-312840-jvdph782 45 2 18 18 CD cord-312840-jvdph782 45 3 ] ] -RRB- cord-312840-jvdph782 45 4 have have VBP cord-312840-jvdph782 45 5 similarly similarly RB cord-312840-jvdph782 45 6 shown show VBN cord-312840-jvdph782 45 7 that that IN cord-312840-jvdph782 45 8 the the DT cord-312840-jvdph782 45 9 rate rate NN cord-312840-jvdph782 45 10 in in IN cord-312840-jvdph782 45 11 change change NN cord-312840-jvdph782 45 12 of of IN cord-312840-jvdph782 45 13 the the DT cord-312840-jvdph782 45 14 reproductive reproductive JJ cord-312840-jvdph782 45 15 number number NN cord-312840-jvdph782 45 16 for for IN cord-312840-jvdph782 45 17 a a DT cord-312840-jvdph782 45 18 particular particular JJ cord-312840-jvdph782 45 19 group group NN cord-312840-jvdph782 45 20 is be VBZ cord-312840-jvdph782 45 21 related relate VBN cord-312840-jvdph782 45 22 to to IN cord-312840-jvdph782 45 23 the the DT cord-312840-jvdph782 45 24 incidence incidence NN cord-312840-jvdph782 45 25 of of IN cord-312840-jvdph782 45 26 infection infection NN cord-312840-jvdph782 45 27 and and CC cord-312840-jvdph782 45 28 force force NN cord-312840-jvdph782 45 29 of of IN cord-312840-jvdph782 45 30 infection infection NN cord-312840-jvdph782 45 31 and and CC cord-312840-jvdph782 45 32 suggest suggest VBP cord-312840-jvdph782 45 33 allocating allocate VBG cord-312840-jvdph782 45 34 resources resource NNS cord-312840-jvdph782 45 35 based base VBN cord-312840-jvdph782 45 36 on on IN cord-312840-jvdph782 45 37 examining examine VBG cord-312840-jvdph782 45 38 these these DT cord-312840-jvdph782 45 39 two two CD cord-312840-jvdph782 45 40 quantities quantity NNS cord-312840-jvdph782 45 41 . . . cord-312840-jvdph782 46 1 In in IN cord-312840-jvdph782 46 2 the the DT cord-312840-jvdph782 46 3 present present JJ cord-312840-jvdph782 46 4 study study NN cord-312840-jvdph782 46 5 , , , cord-312840-jvdph782 46 6 we -PRON- PRP cord-312840-jvdph782 46 7 present present VBP cord-312840-jvdph782 46 8 a a DT cord-312840-jvdph782 46 9 new new JJ cord-312840-jvdph782 46 10 approach approach NN cord-312840-jvdph782 46 11 to to IN cord-312840-jvdph782 46 12 estimating estimate VBG cord-312840-jvdph782 46 13 the the DT cord-312840-jvdph782 46 14 reproductive reproductive JJ cord-312840-jvdph782 46 15 number number NN cord-312840-jvdph782 46 16 by by IN cord-312840-jvdph782 46 17 age age NN cord-312840-jvdph782 46 18 group group NN cord-312840-jvdph782 46 19 by by IN cord-312840-jvdph782 46 20 modifying modify VBG cord-312840-jvdph782 46 21 a a DT cord-312840-jvdph782 46 22 method method NN cord-312840-jvdph782 46 23 initially initially RB cord-312840-jvdph782 46 24 proposed propose VBN cord-312840-jvdph782 46 25 by by IN cord-312840-jvdph782 46 26 Wallinga Wallinga NNP cord-312840-jvdph782 46 27 and and CC cord-312840-jvdph782 46 28 Tuenis Tuenis NNP cord-312840-jvdph782 46 29 [ [ -LRB- cord-312840-jvdph782 46 30 20 20 CD cord-312840-jvdph782 46 31 ] ] -RRB- cord-312840-jvdph782 46 32 . . . cord-312840-jvdph782 47 1 We -PRON- PRP cord-312840-jvdph782 47 2 study study VBP cord-312840-jvdph782 47 3 age age NN cord-312840-jvdph782 47 4 dynamics dynamic NNS cord-312840-jvdph782 47 5 in in IN cord-312840-jvdph782 47 6 South South NNP cord-312840-jvdph782 47 7 Africa Africa NNP cord-312840-jvdph782 47 8 during during IN cord-312840-jvdph782 47 9 the the DT cord-312840-jvdph782 47 10 2009 2009 CD cord-312840-jvdph782 47 11 Influenza Influenza NNP cord-312840-jvdph782 47 12 H1N1 H1N1 NNP cord-312840-jvdph782 47 13 pandemic pandemic NN cord-312840-jvdph782 47 14 and and CC cord-312840-jvdph782 47 15 illustrate illustrate VBP cord-312840-jvdph782 47 16 the the DT cord-312840-jvdph782 47 17 importance importance NN cord-312840-jvdph782 47 18 of of IN cord-312840-jvdph782 47 19 an an DT cord-312840-jvdph782 47 20 appropriately appropriately RB cord-312840-jvdph782 47 21 estimated estimate VBN cord-312840-jvdph782 47 22 measure measure NN cord-312840-jvdph782 47 23 of of IN cord-312840-jvdph782 47 24 the the DT cord-312840-jvdph782 47 25 transmission transmission NN cord-312840-jvdph782 47 26 dynamics dynamic NNS cord-312840-jvdph782 47 27 on on IN cord-312840-jvdph782 47 28 final final JJ cord-312840-jvdph782 47 29 estimates estimate NNS cord-312840-jvdph782 47 30 . . . cord-312840-jvdph782 48 1 Finally finally RB cord-312840-jvdph782 48 2 , , , cord-312840-jvdph782 48 3 we -PRON- PRP cord-312840-jvdph782 48 4 discuss discuss VBP cord-312840-jvdph782 48 5 our -PRON- PRP$ cord-312840-jvdph782 48 6 results result NNS cord-312840-jvdph782 48 7 and and CC cord-312840-jvdph782 48 8 their -PRON- PRP$ cord-312840-jvdph782 48 9 implications implication NNS cord-312840-jvdph782 48 10 for for IN cord-312840-jvdph782 48 11 future future JJ cord-312840-jvdph782 48 12 studies study NNS cord-312840-jvdph782 48 13 on on IN cord-312840-jvdph782 48 14 how how WRB cord-312840-jvdph782 48 15 to to TO cord-312840-jvdph782 48 16 respond respond VB cord-312840-jvdph782 48 17 during during IN cord-312840-jvdph782 48 18 an an DT cord-312840-jvdph782 48 19 emerging emerge VBG cord-312840-jvdph782 48 20 outbreak outbreak NN cord-312840-jvdph782 48 21 . . . cord-312840-jvdph782 49 1 We -PRON- PRP cord-312840-jvdph782 49 2 use use VBP cord-312840-jvdph782 49 3 de de JJ cord-312840-jvdph782 49 4 - - JJ cord-312840-jvdph782 49 5 identified identify VBN cord-312840-jvdph782 49 6 data datum NNS cord-312840-jvdph782 49 7 previously previously RB cord-312840-jvdph782 49 8 reported report VBN cord-312840-jvdph782 49 9 in in IN cord-312840-jvdph782 49 10 [ [ -LRB- cord-312840-jvdph782 49 11 21 21 CD cord-312840-jvdph782 49 12 ] ] -RRB- cord-312840-jvdph782 49 13 that that WDT cord-312840-jvdph782 49 14 includes include VBZ cord-312840-jvdph782 49 15 a a DT cord-312840-jvdph782 49 16 line line NN cord-312840-jvdph782 49 17 list list NN cord-312840-jvdph782 49 18 of of IN cord-312840-jvdph782 49 19 the the DT cord-312840-jvdph782 49 20 12,543 12,543 CD cord-312840-jvdph782 49 21 confirmed confirm VBN cord-312840-jvdph782 49 22 cases case NNS cord-312840-jvdph782 49 23 reported report VBN cord-312840-jvdph782 49 24 in in IN cord-312840-jvdph782 49 25 South South NNP cord-312840-jvdph782 49 26 Africa Africa NNP cord-312840-jvdph782 49 27 during during IN cord-312840-jvdph782 49 28 that that DT cord-312840-jvdph782 49 29 outbreak outbreak NN cord-312840-jvdph782 49 30 . . . cord-312840-jvdph782 50 1 Included include VBN cord-312840-jvdph782 50 2 in in IN cord-312840-jvdph782 50 3 the the DT cord-312840-jvdph782 50 4 data datum NNS cord-312840-jvdph782 50 5 are be VBP cord-312840-jvdph782 50 6 the the DT cord-312840-jvdph782 50 7 ages age NNS cord-312840-jvdph782 50 8 of of IN cord-312840-jvdph782 50 9 the the DT cord-312840-jvdph782 50 10 individuals individual NNS cord-312840-jvdph782 50 11 , , , cord-312840-jvdph782 50 12 the the DT cord-312840-jvdph782 50 13 provinces province NNS cord-312840-jvdph782 50 14 where where WRB cord-312840-jvdph782 50 15 the the DT cord-312840-jvdph782 50 16 specimens specimen NNS cord-312840-jvdph782 50 17 were be VBD cord-312840-jvdph782 50 18 collected collect VBN cord-312840-jvdph782 50 19 , , , cord-312840-jvdph782 50 20 the the DT cord-312840-jvdph782 50 21 sex sex NN cord-312840-jvdph782 50 22 of of IN cord-312840-jvdph782 50 23 the the DT cord-312840-jvdph782 50 24 individuals individual NNS cord-312840-jvdph782 50 25 , , , cord-312840-jvdph782 50 26 the the DT cord-312840-jvdph782 50 27 dates date NNS cord-312840-jvdph782 50 28 of of IN cord-312840-jvdph782 50 29 onset onset NN cord-312840-jvdph782 50 30 of of IN cord-312840-jvdph782 50 31 symptoms symptom NNS cord-312840-jvdph782 50 32 , , , cord-312840-jvdph782 50 33 and and CC cord-312840-jvdph782 50 34 the the DT cord-312840-jvdph782 50 35 dates date NNS cord-312840-jvdph782 50 36 of of IN cord-312840-jvdph782 50 37 the the DT cord-312840-jvdph782 50 38 reporting reporting NN cord-312840-jvdph782 50 39 of of IN cord-312840-jvdph782 50 40 specimens specimen NNS cord-312840-jvdph782 50 41 . . . cord-312840-jvdph782 51 1 The the DT cord-312840-jvdph782 51 2 information information NN cord-312840-jvdph782 51 3 on on IN cord-312840-jvdph782 51 4 the the DT cord-312840-jvdph782 51 5 date date NN cord-312840-jvdph782 51 6 of of IN cord-312840-jvdph782 51 7 symptom symptom NN cord-312840-jvdph782 51 8 onset onset NN cord-312840-jvdph782 51 9 was be VBD cord-312840-jvdph782 51 10 reported report VBN cord-312840-jvdph782 51 11 for for IN cord-312840-jvdph782 51 12 758 758 CD cord-312840-jvdph782 51 13 cases case NNS cord-312840-jvdph782 51 14 ( ( -LRB- cord-312840-jvdph782 51 15 6 6 CD cord-312840-jvdph782 51 16 % % NN cord-312840-jvdph782 51 17 ) ) -RRB- cord-312840-jvdph782 51 18 . . . cord-312840-jvdph782 52 1 We -PRON- PRP cord-312840-jvdph782 52 2 use use VBP cord-312840-jvdph782 52 3 multiple multiple JJ cord-312840-jvdph782 52 4 imputation imputation NN cord-312840-jvdph782 52 5 techniques technique NNS cord-312840-jvdph782 52 6 to to TO cord-312840-jvdph782 52 7 create create VB cord-312840-jvdph782 52 8 500 500 CD cord-312840-jvdph782 52 9 different different JJ cord-312840-jvdph782 52 10 datasets dataset NNS cord-312840-jvdph782 52 11 with with IN cord-312840-jvdph782 52 12 the the DT cord-312840-jvdph782 52 13 missing miss VBG cord-312840-jvdph782 52 14 onset onset NN cord-312840-jvdph782 52 15 times time NNS cord-312840-jvdph782 52 16 imputed impute VBN cord-312840-jvdph782 52 17 , , , cord-312840-jvdph782 52 18 as as IN cord-312840-jvdph782 52 19 predicted predict VBN cord-312840-jvdph782 52 20 by by IN cord-312840-jvdph782 52 21 the the DT cord-312840-jvdph782 52 22 province province NN cord-312840-jvdph782 52 23 and and CC cord-312840-jvdph782 52 24 an an DT cord-312840-jvdph782 52 25 indicator indicator NN cord-312840-jvdph782 52 26 of of IN cord-312840-jvdph782 52 27 whether whether IN cord-312840-jvdph782 52 28 the the DT cord-312840-jvdph782 52 29 specimen specimen NN cord-312840-jvdph782 52 30 was be VBD cord-312840-jvdph782 52 31 collected collect VBN cord-312840-jvdph782 52 32 on on IN cord-312840-jvdph782 52 33 a a DT cord-312840-jvdph782 52 34 weekday weekday NN cord-312840-jvdph782 52 35 or or CC cord-312840-jvdph782 52 36 weekend weekend NN cord-312840-jvdph782 52 37 , , , cord-312840-jvdph782 52 38 using use VBG cord-312840-jvdph782 52 39 Poisson Poisson NNP cord-312840-jvdph782 52 40 regression regression NN cord-312840-jvdph782 52 41 [ [ -LRB- cord-312840-jvdph782 52 42 22 22 CD cord-312840-jvdph782 52 43 ] ] -RRB- cord-312840-jvdph782 52 44 . . . cord-312840-jvdph782 53 1 We -PRON- PRP cord-312840-jvdph782 53 2 report report VBP cord-312840-jvdph782 53 3 the the DT cord-312840-jvdph782 53 4 averages average NNS cord-312840-jvdph782 53 5 and and CC cord-312840-jvdph782 53 6 ranges range VBZ cord-312840-jvdph782 53 7 over over IN cord-312840-jvdph782 53 8 the the DT cord-312840-jvdph782 53 9 500 500 CD cord-312840-jvdph782 53 10 imputed impute VBN cord-312840-jvdph782 53 11 datasets dataset NNS cord-312840-jvdph782 53 12 . . . cord-312840-jvdph782 54 1 Contact contact NN cord-312840-jvdph782 54 2 tracing trace VBG cord-312840-jvdph782 54 3 information information NN cord-312840-jvdph782 54 4 was be VBD cord-312840-jvdph782 54 5 collected collect VBN cord-312840-jvdph782 54 6 on on IN cord-312840-jvdph782 54 7 100 100 CD cord-312840-jvdph782 54 8 initial initial JJ cord-312840-jvdph782 54 9 cases case NNS cord-312840-jvdph782 54 10 , , , cord-312840-jvdph782 54 11 to to TO cord-312840-jvdph782 54 12 provide provide VB cord-312840-jvdph782 54 13 an an DT cord-312840-jvdph782 54 14 estimate estimate NN cord-312840-jvdph782 54 15 of of IN cord-312840-jvdph782 54 16 the the DT cord-312840-jvdph782 54 17 serial serial JJ cord-312840-jvdph782 54 18 interval interval NN cord-312840-jvdph782 54 19 , , , cord-312840-jvdph782 54 20 as as IN cord-312840-jvdph782 54 21 has have VBZ cord-312840-jvdph782 54 22 been be VBN cord-312840-jvdph782 54 23 previously previously RB cord-312840-jvdph782 54 24 reported report VBN cord-312840-jvdph782 54 25 [ [ -LRB- cord-312840-jvdph782 54 26 21 21 CD cord-312840-jvdph782 54 27 ] ] -RRB- cord-312840-jvdph782 54 28 . . . cord-312840-jvdph782 55 1 We -PRON- PRP cord-312840-jvdph782 55 2 only only RB cord-312840-jvdph782 55 3 use use VBP cord-312840-jvdph782 55 4 data datum NNS cord-312840-jvdph782 55 5 from from IN cord-312840-jvdph782 55 6 Gauteng Gauteng NNP cord-312840-jvdph782 55 7 province province NN cord-312840-jvdph782 55 8 ( ( -LRB- cord-312840-jvdph782 55 9 n n NN cord-312840-jvdph782 55 10 = = SYM cord-312840-jvdph782 55 11 5579 5579 CD cord-312840-jvdph782 55 12 , , , cord-312840-jvdph782 55 13 44 44 CD cord-312840-jvdph782 55 14 % % NN cord-312840-jvdph782 55 15 of of IN cord-312840-jvdph782 55 16 cases case NNS cord-312840-jvdph782 55 17 ) ) -RRB- cord-312840-jvdph782 55 18 to to TO cord-312840-jvdph782 55 19 avoid avoid VB cord-312840-jvdph782 55 20 confounding confound VBG cord-312840-jvdph782 55 21 the the DT cord-312840-jvdph782 55 22 results result NNS cord-312840-jvdph782 55 23 with with IN cord-312840-jvdph782 55 24 potential potential JJ cord-312840-jvdph782 55 25 spatial spatial JJ cord-312840-jvdph782 55 26 variation variation NN cord-312840-jvdph782 55 27 in in IN cord-312840-jvdph782 55 28 transmission transmission NN cord-312840-jvdph782 55 29 . . . cord-312840-jvdph782 56 1 Gauteng Gauteng NNP cord-312840-jvdph782 56 2 province province NN cord-312840-jvdph782 56 3 is be VBZ cord-312840-jvdph782 56 4 the the DT cord-312840-jvdph782 56 5 most most RBS cord-312840-jvdph782 56 6 populous populous JJ cord-312840-jvdph782 56 7 , , , cord-312840-jvdph782 56 8 yet yet CC cord-312840-jvdph782 56 9 smallest small JJS cord-312840-jvdph782 56 10 geographically geographically RB cord-312840-jvdph782 56 11 , , , cord-312840-jvdph782 56 12 of of IN cord-312840-jvdph782 56 13 the the DT cord-312840-jvdph782 56 14 nine nine CD cord-312840-jvdph782 56 15 provinces province NNS cord-312840-jvdph782 56 16 in in IN cord-312840-jvdph782 56 17 South South NNP cord-312840-jvdph782 56 18 Africa Africa NNP cord-312840-jvdph782 56 19 , , , cord-312840-jvdph782 56 20 with with IN cord-312840-jvdph782 56 21 over over IN cord-312840-jvdph782 56 22 10 10 CD cord-312840-jvdph782 56 23 million million CD cord-312840-jvdph782 56 24 inhabitants inhabitant NNS cord-312840-jvdph782 56 25 , , , cord-312840-jvdph782 56 26 predominantly predominantly RB cord-312840-jvdph782 56 27 in in IN cord-312840-jvdph782 56 28 the the DT cord-312840-jvdph782 56 29 cities city NNS cord-312840-jvdph782 56 30 of of IN cord-312840-jvdph782 56 31 Johannesburg Johannesburg NNP cord-312840-jvdph782 56 32 and and CC cord-312840-jvdph782 56 33 Pretoria Pretoria NNP cord-312840-jvdph782 56 34 . . . cord-312840-jvdph782 57 1 Wallinga Wallinga NNP cord-312840-jvdph782 57 2 and and CC cord-312840-jvdph782 57 3 Teunis Teunis NNP cord-312840-jvdph782 57 4 [ [ -LRB- cord-312840-jvdph782 57 5 20 20 CD cord-312840-jvdph782 57 6 ] ] -RRB- cord-312840-jvdph782 58 1 ( ( -LRB- cord-312840-jvdph782 58 2 denoted denoted JJ cord-312840-jvdph782 58 3 WT WT NNP cord-312840-jvdph782 58 4 method method NN cord-312840-jvdph782 58 5 hereafter hereafter RB cord-312840-jvdph782 58 6 ) ) -RRB- cord-312840-jvdph782 58 7 proposed propose VBD cord-312840-jvdph782 58 8 a a DT cord-312840-jvdph782 58 9 method method NN cord-312840-jvdph782 58 10 for for IN cord-312840-jvdph782 58 11 the the DT cord-312840-jvdph782 58 12 estimation estimation NN cord-312840-jvdph782 58 13 of of IN cord-312840-jvdph782 58 14 the the DT cord-312840-jvdph782 58 15 effective effective JJ cord-312840-jvdph782 58 16 reproductive reproductive JJ cord-312840-jvdph782 58 17 number number NN cord-312840-jvdph782 58 18 by by IN cord-312840-jvdph782 58 19 making make VBG cord-312840-jvdph782 58 20 use use NN cord-312840-jvdph782 58 21 of of IN cord-312840-jvdph782 58 22 the the DT cord-312840-jvdph782 58 23 epidemic epidemic NN cord-312840-jvdph782 58 24 curve curve NN cord-312840-jvdph782 58 25 , , , cord-312840-jvdph782 58 26 N n NN cord-312840-jvdph782 58 27 = = NN cord-312840-jvdph782 58 28 { { -LRB- cord-312840-jvdph782 58 29 N N NNP cord-312840-jvdph782 58 30 1 1 CD cord-312840-jvdph782 58 31 , , , cord-312840-jvdph782 58 32 … … NFP cord-312840-jvdph782 58 33 , , , cord-312840-jvdph782 58 34 N N NNP cord-312840-jvdph782 58 35 T T NNP cord-312840-jvdph782 58 36 } } -RRB- cord-312840-jvdph782 58 37 , , , cord-312840-jvdph782 58 38 where where WRB cord-312840-jvdph782 58 39 N N NNP cord-312840-jvdph782 58 40 t t NN cord-312840-jvdph782 58 41 is be VBZ cord-312840-jvdph782 58 42 the the DT cord-312840-jvdph782 58 43 number number NN cord-312840-jvdph782 58 44 of of IN cord-312840-jvdph782 58 45 cases case NNS cord-312840-jvdph782 58 46 at at IN cord-312840-jvdph782 58 47 time time NN cord-312840-jvdph782 58 48 point point NN cord-312840-jvdph782 58 49 t t NNP cord-312840-jvdph782 58 50 , , , cord-312840-jvdph782 58 51 and and CC cord-312840-jvdph782 58 52 an an DT cord-312840-jvdph782 58 53 estimate estimate NN cord-312840-jvdph782 58 54 of of IN cord-312840-jvdph782 58 55 the the DT cord-312840-jvdph782 58 56 serial serial JJ cord-312840-jvdph782 58 57 interval interval NN cord-312840-jvdph782 58 58 , , , cord-312840-jvdph782 58 59 p p NN cord-312840-jvdph782 58 60 1 1 CD cord-312840-jvdph782 58 61 , , , cord-312840-jvdph782 58 62 … … NFP cord-312840-jvdph782 58 63 , , , cord-312840-jvdph782 58 64 p p NN cord-312840-jvdph782 58 65 k k NN cord-312840-jvdph782 58 66 , , , cord-312840-jvdph782 58 67 where where WRB cord-312840-jvdph782 58 68 p p NNP cord-312840-jvdph782 58 69 i i PRP cord-312840-jvdph782 58 70 describes describe VBZ cord-312840-jvdph782 58 71 the the DT cord-312840-jvdph782 58 72 probability probability NN cord-312840-jvdph782 58 73 of of IN cord-312840-jvdph782 58 74 a a DT cord-312840-jvdph782 58 75 serial serial JJ cord-312840-jvdph782 58 76 interval interval NN cord-312840-jvdph782 58 77 of of IN cord-312840-jvdph782 58 78 length length NN cord-312840-jvdph782 58 79 i i PRP cord-312840-jvdph782 58 80 and and CC cord-312840-jvdph782 58 81 the the DT cord-312840-jvdph782 58 82 maximum maximum JJ cord-312840-jvdph782 58 83 serial serial JJ cord-312840-jvdph782 58 84 interval interval NN cord-312840-jvdph782 58 85 length length NN cord-312840-jvdph782 58 86 is be VBZ cord-312840-jvdph782 58 87 k. k. NNP cord-312840-jvdph782 59 1 We -PRON- PRP cord-312840-jvdph782 59 2 review review VBP cord-312840-jvdph782 59 3 this this DT cord-312840-jvdph782 59 4 method method NN cord-312840-jvdph782 59 5 in in IN cord-312840-jvdph782 59 6 Appendix Appendix NNP cord-312840-jvdph782 59 7 1 1 CD cord-312840-jvdph782 59 8 . . . cord-312840-jvdph782 60 1 The the DT cord-312840-jvdph782 60 2 estimator estimator NN cord-312840-jvdph782 60 3 they -PRON- PRP cord-312840-jvdph782 60 4 obtain obtain VBP cord-312840-jvdph782 60 5 for for IN cord-312840-jvdph782 60 6 the the DT cord-312840-jvdph782 60 7 effective effective JJ cord-312840-jvdph782 60 8 reproductive reproductive JJ cord-312840-jvdph782 60 9 number number NN cord-312840-jvdph782 60 10 for for IN cord-312840-jvdph782 60 11 individual individual JJ cord-312840-jvdph782 60 12 j j NNP cord-312840-jvdph782 60 13 on on IN cord-312840-jvdph782 60 14 day day NN cord-312840-jvdph782 60 15 t t NNP cord-312840-jvdph782 60 16 ' ' '' cord-312840-jvdph782 60 17 is be VBZ cord-312840-jvdph782 60 18 where where WRB cord-312840-jvdph782 60 19 n n NNP cord-312840-jvdph782 60 20 s s NNP cord-312840-jvdph782 60 21 denotes denote VBZ cord-312840-jvdph782 60 22 the the DT cord-312840-jvdph782 60 23 number number NN cord-312840-jvdph782 60 24 with with IN cord-312840-jvdph782 60 25 symptom symptom NN cord-312840-jvdph782 60 26 onset onset NN cord-312840-jvdph782 60 27 on on IN cord-312840-jvdph782 60 28 day day NN cord-312840-jvdph782 60 29 s s NNP cord-312840-jvdph782 60 30 and and CC cord-312840-jvdph782 60 31 q q NNP cord-312840-jvdph782 60 32 s s NNP cord-312840-jvdph782 60 33 , , , cord-312840-jvdph782 60 34 t t NNP cord-312840-jvdph782 60 35 denotes denote VBZ cord-312840-jvdph782 60 36 the the DT cord-312840-jvdph782 60 37 relative relative JJ cord-312840-jvdph782 60 38 probability probability NN cord-312840-jvdph782 60 39 that that WDT cord-312840-jvdph782 60 40 case case NN cord-312840-jvdph782 60 41 s s PRP cord-312840-jvdph782 60 42 was be VBD cord-312840-jvdph782 60 43 infected infect VBN cord-312840-jvdph782 60 44 by by IN cord-312840-jvdph782 60 45 case case NN cord-312840-jvdph782 60 46 t. t. NN cord-312840-jvdph782 61 1 We -PRON- PRP cord-312840-jvdph782 61 2 propose propose VBP cord-312840-jvdph782 61 3 the the DT cord-312840-jvdph782 61 4 use use NN cord-312840-jvdph782 61 5 of of IN cord-312840-jvdph782 61 6 additional additional JJ cord-312840-jvdph782 61 7 structure structure NN cord-312840-jvdph782 61 8 in in IN cord-312840-jvdph782 61 9 this this DT cord-312840-jvdph782 61 10 method method NN cord-312840-jvdph782 61 11 to to TO cord-312840-jvdph782 61 12 describe describe VB cord-312840-jvdph782 61 13 the the DT cord-312840-jvdph782 61 14 probability probability NN cord-312840-jvdph782 61 15 of of IN cord-312840-jvdph782 61 16 an an DT cord-312840-jvdph782 61 17 infection infection NN cord-312840-jvdph782 61 18 event event NN cord-312840-jvdph782 61 19 occurring occur VBG cord-312840-jvdph782 61 20 between between IN cord-312840-jvdph782 61 21 two two CD cord-312840-jvdph782 61 22 cases case NNS cord-312840-jvdph782 61 23 that that WDT cord-312840-jvdph782 61 24 incorporates incorporate VBZ cord-312840-jvdph782 61 25 information information NN cord-312840-jvdph782 61 26 on on IN cord-312840-jvdph782 61 27 their -PRON- PRP$ cord-312840-jvdph782 61 28 ages age NNS cord-312840-jvdph782 61 29 by by IN cord-312840-jvdph782 61 30 modifying modify VBG cord-312840-jvdph782 61 31 the the DT cord-312840-jvdph782 61 32 probability probability NN cord-312840-jvdph782 61 33 of of IN cord-312840-jvdph782 61 34 transmission transmission NN cord-312840-jvdph782 61 35 to to TO cord-312840-jvdph782 61 36 be be VB cord-312840-jvdph782 61 37 : : : cord-312840-jvdph782 61 38 where where WRB cord-312840-jvdph782 61 39 a a DT cord-312840-jvdph782 61 40 j j NNP cord-312840-jvdph782 61 41 is be VBZ cord-312840-jvdph782 61 42 the the DT cord-312840-jvdph782 61 43 age age NN cord-312840-jvdph782 61 44 group group NN cord-312840-jvdph782 61 45 of of IN cord-312840-jvdph782 61 46 individual individual NNP cord-312840-jvdph782 61 47 j j NNP cord-312840-jvdph782 61 48 and and CC cord-312840-jvdph782 61 49 w w NNP cord-312840-jvdph782 61 50 a a DT cord-312840-jvdph782 61 51 i i NN cord-312840-jvdph782 61 52 0 0 CD cord-312840-jvdph782 62 1 a a DT cord-312840-jvdph782 62 2 j j NNP cord-312840-jvdph782 62 3 is be VBZ cord-312840-jvdph782 62 4 a a DT cord-312840-jvdph782 62 5 measure measure NN cord-312840-jvdph782 62 6 of of IN cord-312840-jvdph782 62 7 the the DT cord-312840-jvdph782 62 8 likelihood likelihood NN cord-312840-jvdph782 62 9 of of IN cord-312840-jvdph782 62 10 transmission transmission NN cord-312840-jvdph782 62 11 between between IN cord-312840-jvdph782 62 12 individuals individual NNS cord-312840-jvdph782 62 13 in in IN cord-312840-jvdph782 62 14 age age NN cord-312840-jvdph782 62 15 group group NN cord-312840-jvdph782 62 16 a a DT cord-312840-jvdph782 62 17 i i NN cord-312840-jvdph782 62 18 and and CC cord-312840-jvdph782 62 19 a a DT cord-312840-jvdph782 62 20 j j NNP cord-312840-jvdph782 62 21 . . . cord-312840-jvdph782 63 1 The the DT cord-312840-jvdph782 63 2 matrix matrix NN cord-312840-jvdph782 63 3 W w NN cord-312840-jvdph782 63 4 = = SYM cord-312840-jvdph782 63 5 { { -LRB- cord-312840-jvdph782 63 6 w w IN cord-312840-jvdph782 63 7 a a DT cord-312840-jvdph782 63 8 i i NN cord-312840-jvdph782 63 9 a a DT cord-312840-jvdph782 63 10 j j NNP cord-312840-jvdph782 63 11 } } -RRB- cord-312840-jvdph782 63 12 does do VBZ cord-312840-jvdph782 63 13 not not RB cord-312840-jvdph782 63 14 necessarily necessarily RB cord-312840-jvdph782 63 15 have have VB cord-312840-jvdph782 63 16 to to TO cord-312840-jvdph782 63 17 be be VB cord-312840-jvdph782 63 18 symmetric symmetric JJ cord-312840-jvdph782 63 19 . . . cord-312840-jvdph782 64 1 This this DT cord-312840-jvdph782 64 2 method method NN cord-312840-jvdph782 64 3 requires require VBZ cord-312840-jvdph782 64 4 information information NN cord-312840-jvdph782 64 5 on on IN cord-312840-jvdph782 64 6 the the DT cord-312840-jvdph782 64 7 likelihood likelihood NN cord-312840-jvdph782 64 8 of of IN cord-312840-jvdph782 64 9 infectious infectious JJ cord-312840-jvdph782 64 10 contact contact NN cord-312840-jvdph782 64 11 between between IN cord-312840-jvdph782 64 12 different different JJ cord-312840-jvdph782 64 13 age age NN cord-312840-jvdph782 64 14 groups group NNS cord-312840-jvdph782 64 15 , , , cord-312840-jvdph782 64 16 or or CC cord-312840-jvdph782 64 17 the the DT cord-312840-jvdph782 64 18 w w NN cord-312840-jvdph782 64 19 a a NN cord-312840-jvdph782 65 1 i i PRP cord-312840-jvdph782 65 2 a a DT cord-312840-jvdph782 65 3 j j NNP cord-312840-jvdph782 65 4 . . . cord-312840-jvdph782 66 1 Increasingly increasingly RB cord-312840-jvdph782 66 2 studies study NNS cord-312840-jvdph782 66 3 are be VBP cord-312840-jvdph782 66 4 being be VBG cord-312840-jvdph782 66 5 conducted conduct VBN cord-312840-jvdph782 66 6 to to TO cord-312840-jvdph782 66 7 obtain obtain VB cord-312840-jvdph782 66 8 such such JJ cord-312840-jvdph782 66 9 information information NN cord-312840-jvdph782 66 10 by by IN cord-312840-jvdph782 66 11 assuming assume VBG cord-312840-jvdph782 66 12 that that IN cord-312840-jvdph782 66 13 transmission transmission NN cord-312840-jvdph782 66 14 is be VBZ cord-312840-jvdph782 66 15 directly directly RB cord-312840-jvdph782 66 16 related relate VBN cord-312840-jvdph782 66 17 to to IN cord-312840-jvdph782 66 18 contact contact NN cord-312840-jvdph782 66 19 patterns pattern NNS cord-312840-jvdph782 66 20 . . . cord-312840-jvdph782 67 1 We -PRON- PRP cord-312840-jvdph782 67 2 use use VBP cord-312840-jvdph782 67 3 the the DT cord-312840-jvdph782 67 4 results result NNS cord-312840-jvdph782 67 5 of of IN cord-312840-jvdph782 67 6 two two CD cord-312840-jvdph782 67 7 such such JJ cord-312840-jvdph782 67 8 studies study NNS cord-312840-jvdph782 67 9 : : : cord-312840-jvdph782 67 10 The the DT cord-312840-jvdph782 67 11 first first JJ cord-312840-jvdph782 67 12 is be VBZ cord-312840-jvdph782 67 13 a a DT cord-312840-jvdph782 67 14 study study NN cord-312840-jvdph782 67 15 of of IN cord-312840-jvdph782 67 16 571 571 CD cord-312840-jvdph782 67 17 randomly randomly RB cord-312840-jvdph782 67 18 selected select VBN cord-312840-jvdph782 67 19 individuals individual NNS cord-312840-jvdph782 67 20 in in IN cord-312840-jvdph782 67 21 a a DT cord-312840-jvdph782 67 22 South South NNP cord-312840-jvdph782 67 23 Africa Africa NNP cord-312840-jvdph782 67 24 township township NN cord-312840-jvdph782 67 25 performed perform VBN cord-312840-jvdph782 67 26 in in IN cord-312840-jvdph782 67 27 2010 2010 CD cord-312840-jvdph782 67 28 and and CC cord-312840-jvdph782 67 29 reported report VBN cord-312840-jvdph782 67 30 by by IN cord-312840-jvdph782 67 31 Johnstone Johnstone NNP cord-312840-jvdph782 67 32 - - HYPH cord-312840-jvdph782 67 33 Robertson Robertson NNP cord-312840-jvdph782 67 34 et et NNP cord-312840-jvdph782 67 35 al al NNP cord-312840-jvdph782 67 36 . . . cord-312840-jvdph782 68 1 [ [ -LRB- cord-312840-jvdph782 68 2 12 12 CD cord-312840-jvdph782 68 3 ] ] -RRB- cord-312840-jvdph782 68 4 . . . cord-312840-jvdph782 69 1 The the DT cord-312840-jvdph782 69 2 authors author NNS cord-312840-jvdph782 69 3 report report VBP cord-312840-jvdph782 69 4 two two CD cord-312840-jvdph782 69 5 matrices matrix NNS cord-312840-jvdph782 69 6 with with IN cord-312840-jvdph782 69 7 age age NN cord-312840-jvdph782 69 8 specific specific JJ cord-312840-jvdph782 69 9 contact contact NN cord-312840-jvdph782 69 10 patterns pattern NNS cord-312840-jvdph782 69 11 in in IN cord-312840-jvdph782 69 12 five five CD cord-312840-jvdph782 69 13 year year NN cord-312840-jvdph782 69 14 intervals interval NNS cord-312840-jvdph782 69 15 up up RP cord-312840-jvdph782 69 16 to to IN cord-312840-jvdph782 69 17 a a DT cord-312840-jvdph782 69 18 45 45 CD cord-312840-jvdph782 69 19 + + CD cord-312840-jvdph782 69 20 category category NN cord-312840-jvdph782 69 21 . . . cord-312840-jvdph782 70 1 The the DT cord-312840-jvdph782 70 2 first first JJ cord-312840-jvdph782 70 3 matrix matrix NN cord-312840-jvdph782 70 4 only only RB cord-312840-jvdph782 70 5 considers consider VBZ cord-312840-jvdph782 70 6 contacts contact NNS cord-312840-jvdph782 70 7 that that WDT cord-312840-jvdph782 70 8 involve involve VBP cord-312840-jvdph782 70 9 all all DT cord-312840-jvdph782 70 10 close close JJ cord-312840-jvdph782 70 11 contacts contact NNS cord-312840-jvdph782 70 12 while while IN cord-312840-jvdph782 70 13 the the DT cord-312840-jvdph782 70 14 second second JJ cord-312840-jvdph782 70 15 includes include VBZ cord-312840-jvdph782 70 16 information information NN cord-312840-jvdph782 70 17 on on IN cord-312840-jvdph782 70 18 only only RB cord-312840-jvdph782 70 19 those those DT cord-312840-jvdph782 70 20 contacts contact NNS cord-312840-jvdph782 70 21 that that WDT cord-312840-jvdph782 70 22 involve involve VBP cord-312840-jvdph782 70 23 physical physical JJ cord-312840-jvdph782 70 24 touch touch NN cord-312840-jvdph782 70 25 . . . cord-312840-jvdph782 71 1 The the DT cord-312840-jvdph782 71 2 second second JJ cord-312840-jvdph782 71 3 set set NN cord-312840-jvdph782 71 4 of of IN cord-312840-jvdph782 71 5 matrices matrix NNS cord-312840-jvdph782 71 6 we -PRON- PRP cord-312840-jvdph782 71 7 use use VBP cord-312840-jvdph782 71 8 comes come VBZ cord-312840-jvdph782 71 9 from from IN cord-312840-jvdph782 71 10 the the DT cord-312840-jvdph782 71 11 European European NNP cord-312840-jvdph782 71 12 based base VBN cord-312840-jvdph782 71 13 PolyMod PolyMod NNP cord-312840-jvdph782 71 14 study study NN cord-312840-jvdph782 71 15 of of IN cord-312840-jvdph782 71 16 Mossong Mossong NNP cord-312840-jvdph782 71 17 et et NNP cord-312840-jvdph782 71 18 al al NNP cord-312840-jvdph782 71 19 . . . cord-312840-jvdph782 72 1 [ [ -LRB- cord-312840-jvdph782 72 2 5 5 CD cord-312840-jvdph782 72 3 ] ] -RRB- cord-312840-jvdph782 72 4 . . . cord-312840-jvdph782 73 1 This this DT cord-312840-jvdph782 73 2 study study NN cord-312840-jvdph782 73 3 includes include VBZ cord-312840-jvdph782 73 4 information information NN cord-312840-jvdph782 73 5 on on IN cord-312840-jvdph782 73 6 97,904 97,904 CD cord-312840-jvdph782 73 7 contacts contact NNS cord-312840-jvdph782 73 8 amongst amongst IN cord-312840-jvdph782 73 9 7,290 7,290 CD cord-312840-jvdph782 73 10 participants participant NNS cord-312840-jvdph782 73 11 from from IN cord-312840-jvdph782 73 12 eight eight CD cord-312840-jvdph782 73 13 countries country NNS cord-312840-jvdph782 73 14 in in IN cord-312840-jvdph782 73 15 Europe Europe NNP cord-312840-jvdph782 73 16 : : : cord-312840-jvdph782 73 17 Belgium Belgium NNP cord-312840-jvdph782 73 18 , , , cord-312840-jvdph782 73 19 Finland Finland NNP cord-312840-jvdph782 73 20 , , , cord-312840-jvdph782 73 21 Great Great NNP cord-312840-jvdph782 73 22 Britain Britain NNP cord-312840-jvdph782 73 23 , , , cord-312840-jvdph782 73 24 Germany Germany NNP cord-312840-jvdph782 73 25 , , , cord-312840-jvdph782 73 26 Italy Italy NNP cord-312840-jvdph782 73 27 , , , cord-312840-jvdph782 73 28 Luxembourg Luxembourg NNP cord-312840-jvdph782 73 29 , , , cord-312840-jvdph782 73 30 the the DT cord-312840-jvdph782 73 31 Netherlands Netherlands NNP cord-312840-jvdph782 73 32 , , , cord-312840-jvdph782 73 33 and and CC cord-312840-jvdph782 73 34 Poland Poland NNP cord-312840-jvdph782 73 35 . . . cord-312840-jvdph782 74 1 Contact contact NN cord-312840-jvdph782 74 2 matrices matrix NNS cord-312840-jvdph782 74 3 describe describe VBP cord-312840-jvdph782 74 4 all all DT cord-312840-jvdph782 74 5 close close JJ cord-312840-jvdph782 74 6 contacts contact NNS cord-312840-jvdph782 74 7 , , , cord-312840-jvdph782 74 8 and and CC cord-312840-jvdph782 74 9 then then RB cord-312840-jvdph782 74 10 separately separately RB cord-312840-jvdph782 74 11 , , , cord-312840-jvdph782 74 12 close close JJ cord-312840-jvdph782 74 13 contacts contact NNS cord-312840-jvdph782 74 14 that that WDT cord-312840-jvdph782 74 15 involve involve VBP cord-312840-jvdph782 74 16 physical physical JJ cord-312840-jvdph782 74 17 touch touch NN cord-312840-jvdph782 74 18 . . . cord-312840-jvdph782 75 1 The the DT cord-312840-jvdph782 75 2 matrices matrix NNS cord-312840-jvdph782 75 3 report report VBP cord-312840-jvdph782 75 4 age age NN cord-312840-jvdph782 75 5 - - HYPH cord-312840-jvdph782 75 6 specific specific JJ cord-312840-jvdph782 75 7 values value NNS cord-312840-jvdph782 75 8 for for IN cord-312840-jvdph782 75 9 five five CD cord-312840-jvdph782 75 10 year year NN cord-312840-jvdph782 75 11 age age NN cord-312840-jvdph782 75 12 groups group NNS cord-312840-jvdph782 75 13 up up IN cord-312840-jvdph782 75 14 to to TO cord-312840-jvdph782 75 15 70 70 CD cord-312840-jvdph782 75 16 + + NN cord-312840-jvdph782 75 17 . . . cord-312840-jvdph782 76 1 We -PRON- PRP cord-312840-jvdph782 76 2 modify modify VBP cord-312840-jvdph782 76 3 these these DT cord-312840-jvdph782 76 4 matrices matrix NNS cord-312840-jvdph782 76 5 to to TO cord-312840-jvdph782 76 6 match match VB cord-312840-jvdph782 76 7 those those DT cord-312840-jvdph782 76 8 presented present VBN cord-312840-jvdph782 76 9 by by IN cord-312840-jvdph782 76 10 Johnstone Johnstone NNP cord-312840-jvdph782 76 11 - - HYPH cord-312840-jvdph782 76 12 Robertson Robertson NNP cord-312840-jvdph782 76 13 et et NNP cord-312840-jvdph782 76 14 al al NNP cord-312840-jvdph782 76 15 . . . cord-312840-jvdph782 77 1 [ [ -LRB- cord-312840-jvdph782 77 2 12 12 CD cord-312840-jvdph782 77 3 ] ] -RRB- cord-312840-jvdph782 77 4 and and CC cord-312840-jvdph782 77 5 to to TO cord-312840-jvdph782 77 6 match match VB cord-312840-jvdph782 77 7 the the DT cord-312840-jvdph782 77 8 demographics demographic NNS cord-312840-jvdph782 77 9 of of IN cord-312840-jvdph782 77 10 South South NNP cord-312840-jvdph782 77 11 Africa Africa NNP cord-312840-jvdph782 77 12 's 's POS cord-312840-jvdph782 77 13 young young JJ cord-312840-jvdph782 77 14 population population NN cord-312840-jvdph782 77 15 by by IN cord-312840-jvdph782 77 16 averaging average VBG cord-312840-jvdph782 77 17 all all DT cord-312840-jvdph782 77 18 values value NNS cord-312840-jvdph782 77 19 above above IN cord-312840-jvdph782 77 20 45 45 CD cord-312840-jvdph782 77 21 years year NNS cord-312840-jvdph782 77 22 of of IN cord-312840-jvdph782 77 23 age age NN cord-312840-jvdph782 77 24 to to TO cord-312840-jvdph782 77 25 create create VB cord-312840-jvdph782 77 26 a a DT cord-312840-jvdph782 77 27 single single JJ cord-312840-jvdph782 77 28 45 45 CD cord-312840-jvdph782 77 29 + + CD cord-312840-jvdph782 77 30 age age NN cord-312840-jvdph782 77 31 category category NN cord-312840-jvdph782 77 32 . . . cord-312840-jvdph782 78 1 In in IN cord-312840-jvdph782 78 2 our -PRON- PRP$ cord-312840-jvdph782 78 3 results result NNS cord-312840-jvdph782 78 4 we -PRON- PRP cord-312840-jvdph782 78 5 focus focus VBP cord-312840-jvdph782 78 6 on on IN cord-312840-jvdph782 78 7 those those DT cord-312840-jvdph782 78 8 obtained obtain VBN cord-312840-jvdph782 78 9 using use VBG cord-312840-jvdph782 78 10 the the DT cord-312840-jvdph782 78 11 contact contact NN cord-312840-jvdph782 78 12 matrices matrix NNS cord-312840-jvdph782 78 13 from from IN cord-312840-jvdph782 78 14 South South NNP cord-312840-jvdph782 78 15 Africa Africa NNP cord-312840-jvdph782 78 16 , , , cord-312840-jvdph782 78 17 as as IN cord-312840-jvdph782 78 18 these these DT cord-312840-jvdph782 78 19 matrices matrix NNS cord-312840-jvdph782 78 20 would would MD cord-312840-jvdph782 78 21 seem seem VB cord-312840-jvdph782 78 22 more more RBR cord-312840-jvdph782 78 23 appropriate appropriate JJ cord-312840-jvdph782 78 24 for for IN cord-312840-jvdph782 78 25 the the DT cord-312840-jvdph782 78 26 data datum NNS cord-312840-jvdph782 78 27 at at IN cord-312840-jvdph782 78 28 hand hand NN cord-312840-jvdph782 78 29 . . . cord-312840-jvdph782 79 1 We -PRON- PRP cord-312840-jvdph782 79 2 report report VBP cord-312840-jvdph782 79 3 results result NNS cord-312840-jvdph782 79 4 from from IN cord-312840-jvdph782 79 5 the the DT cord-312840-jvdph782 79 6 PolyMod PolyMod NNP cord-312840-jvdph782 79 7 matrices matrix NNS cord-312840-jvdph782 79 8 as as IN cord-312840-jvdph782 79 9 a a DT cord-312840-jvdph782 79 10 sensitivity sensitivity NN cord-312840-jvdph782 79 11 analysis analysis NN cord-312840-jvdph782 79 12 . . . cord-312840-jvdph782 80 1 We -PRON- PRP cord-312840-jvdph782 80 2 estimate estimate VBP cord-312840-jvdph782 80 3 R r NN cord-312840-jvdph782 80 4 t t NN cord-312840-jvdph782 80 5 and and CC cord-312840-jvdph782 80 6 R R NNP cord-312840-jvdph782 80 7 0 0 NFP cord-312840-jvdph782 80 8 using use VBG cord-312840-jvdph782 80 9 the the DT cord-312840-jvdph782 80 10 18 18 CD cord-312840-jvdph782 80 11 matrices matrix NNS cord-312840-jvdph782 80 12 described describe VBN cord-312840-jvdph782 80 13 above above IN cord-312840-jvdph782 80 14 with with IN cord-312840-jvdph782 80 15 the the DT cord-312840-jvdph782 80 16 imputed imputed JJ cord-312840-jvdph782 80 17 epidemic epidemic NN cord-312840-jvdph782 80 18 data datum NNS cord-312840-jvdph782 80 19 from from IN cord-312840-jvdph782 80 20 South South NNP cord-312840-jvdph782 80 21 Africa Africa NNP cord-312840-jvdph782 80 22 , , , cord-312840-jvdph782 80 23 and and CC cord-312840-jvdph782 80 24 report report NN cord-312840-jvdph782 80 25 age age NN cord-312840-jvdph782 80 26 specific specific JJ cord-312840-jvdph782 80 27 estimates estimate NNS cord-312840-jvdph782 80 28 of of IN cord-312840-jvdph782 80 29 these these DT cord-312840-jvdph782 80 30 quantities quantity NNS cord-312840-jvdph782 80 31 , , , cord-312840-jvdph782 80 32 as as RB cord-312840-jvdph782 80 33 well well RB cord-312840-jvdph782 80 34 as as IN cord-312840-jvdph782 80 35 aggregate aggregate JJ cord-312840-jvdph782 80 36 estimates estimate NNS cord-312840-jvdph782 80 37 across across IN cord-312840-jvdph782 80 38 age age NN cord-312840-jvdph782 80 39 groups group NNS cord-312840-jvdph782 80 40 . . . cord-312840-jvdph782 81 1 The the DT cord-312840-jvdph782 81 2 reproductive reproductive JJ cord-312840-jvdph782 81 3 numbers number NNS cord-312840-jvdph782 81 4 for for IN cord-312840-jvdph782 81 5 each each DT cord-312840-jvdph782 81 6 age age NN cord-312840-jvdph782 81 7 group group NN cord-312840-jvdph782 81 8 represent represent VBP cord-312840-jvdph782 81 9 the the DT cord-312840-jvdph782 81 10 expected expect VBN cord-312840-jvdph782 81 11 number number NN cord-312840-jvdph782 81 12 of of IN cord-312840-jvdph782 81 13 infections infection NNS cord-312840-jvdph782 81 14 generated generate VBN cord-312840-jvdph782 81 15 across across IN cord-312840-jvdph782 81 16 the the DT cord-312840-jvdph782 81 17 population population NN cord-312840-jvdph782 81 18 by by IN cord-312840-jvdph782 81 19 an an DT cord-312840-jvdph782 81 20 individual individual NN cord-312840-jvdph782 81 21 in in IN cord-312840-jvdph782 81 22 that that DT cord-312840-jvdph782 81 23 particular particular JJ cord-312840-jvdph782 81 24 age age NN cord-312840-jvdph782 81 25 group group NN cord-312840-jvdph782 81 26 . . . cord-312840-jvdph782 82 1 In in IN cord-312840-jvdph782 82 2 the the DT cord-312840-jvdph782 82 3 Appendices Appendices NNPS cord-312840-jvdph782 82 4 , , , cord-312840-jvdph782 82 5 we -PRON- PRP cord-312840-jvdph782 82 6 further further RB cord-312840-jvdph782 82 7 report report VBP cord-312840-jvdph782 82 8 the the DT cord-312840-jvdph782 82 9 results result NNS cord-312840-jvdph782 82 10 of of IN cord-312840-jvdph782 82 11 two two CD cord-312840-jvdph782 82 12 sensitivity sensitivity NN cord-312840-jvdph782 82 13 analyses analysis NNS cord-312840-jvdph782 82 14 : : : cord-312840-jvdph782 83 1 First first RB cord-312840-jvdph782 83 2 we -PRON- PRP cord-312840-jvdph782 83 3 test test VBP cord-312840-jvdph782 83 4 the the DT cord-312840-jvdph782 83 5 sensitivity sensitivity NN cord-312840-jvdph782 83 6 of of IN cord-312840-jvdph782 83 7 the the DT cord-312840-jvdph782 83 8 results result NNS cord-312840-jvdph782 83 9 to to IN cord-312840-jvdph782 83 10 potential potential JJ cord-312840-jvdph782 83 11 errors error NNS cord-312840-jvdph782 83 12 in in IN cord-312840-jvdph782 83 13 the the DT cord-312840-jvdph782 83 14 reporting reporting NN cord-312840-jvdph782 83 15 dates date NNS cord-312840-jvdph782 83 16 by by IN cord-312840-jvdph782 83 17 selecting select VBG cord-312840-jvdph782 83 18 a a DT cord-312840-jvdph782 83 19 single single JJ cord-312840-jvdph782 83 20 imputed imputed JJ cord-312840-jvdph782 83 21 dataset dataset NN cord-312840-jvdph782 83 22 and and CC cord-312840-jvdph782 83 23 randomly randomly RB cord-312840-jvdph782 83 24 jittering jittere VBG cord-312840-jvdph782 83 25 the the DT cord-312840-jvdph782 83 26 onset onset NN cord-312840-jvdph782 83 27 dates date NNS cord-312840-jvdph782 83 28 of of IN cord-312840-jvdph782 83 29 10 10 CD cord-312840-jvdph782 83 30 % % NN cord-312840-jvdph782 83 31 of of IN cord-312840-jvdph782 83 32 the the DT cord-312840-jvdph782 83 33 individuals individual NNS cord-312840-jvdph782 83 34 , , , cord-312840-jvdph782 83 35 within within IN cord-312840-jvdph782 83 36 30 30 CD cord-312840-jvdph782 83 37 days day NNS cord-312840-jvdph782 83 38 of of IN cord-312840-jvdph782 83 39 their -PRON- PRP$ cord-312840-jvdph782 83 40 observed observed JJ cord-312840-jvdph782 83 41 ( ( -LRB- cord-312840-jvdph782 83 42 or or CC cord-312840-jvdph782 83 43 imputed impute VBN cord-312840-jvdph782 83 44 ) ) -RRB- cord-312840-jvdph782 83 45 onset onset NN cord-312840-jvdph782 83 46 date date NN cord-312840-jvdph782 83 47 ( ( -LRB- cord-312840-jvdph782 83 48 Appendix Appendix NNP cord-312840-jvdph782 83 49 2 2 CD cord-312840-jvdph782 83 50 ) ) -RRB- cord-312840-jvdph782 83 51 . . . cord-312840-jvdph782 84 1 We -PRON- PRP cord-312840-jvdph782 84 2 create create VBP cord-312840-jvdph782 84 3 50 50 CD cord-312840-jvdph782 84 4 such such JJ cord-312840-jvdph782 84 5 datasets dataset NNS cord-312840-jvdph782 84 6 and and CC cord-312840-jvdph782 84 7 repeat repeat VB cord-312840-jvdph782 84 8 all all DT cord-312840-jvdph782 84 9 analyses analysis NNS cord-312840-jvdph782 84 10 on on IN cord-312840-jvdph782 84 11 these these DT cord-312840-jvdph782 84 12 datasets dataset NNS cord-312840-jvdph782 84 13 and and CC cord-312840-jvdph782 84 14 compare compare VB cord-312840-jvdph782 84 15 these these DT cord-312840-jvdph782 84 16 results result NNS cord-312840-jvdph782 84 17 to to IN cord-312840-jvdph782 84 18 those those DT cord-312840-jvdph782 84 19 obtained obtain VBN cord-312840-jvdph782 84 20 without without IN cord-312840-jvdph782 84 21 jittering jittere VBG cord-312840-jvdph782 84 22 the the DT cord-312840-jvdph782 84 23 data datum NNS cord-312840-jvdph782 84 24 . . . cord-312840-jvdph782 85 1 The the DT cord-312840-jvdph782 85 2 second second JJ cord-312840-jvdph782 85 3 sensitivity sensitivity NN cord-312840-jvdph782 85 4 analysis analysis NN cord-312840-jvdph782 85 5 tests test VBZ cord-312840-jvdph782 85 6 the the DT cord-312840-jvdph782 85 7 impact impact NN cord-312840-jvdph782 85 8 of of IN cord-312840-jvdph782 85 9 differential differential JJ cord-312840-jvdph782 85 10 healthcare healthcare NN cord-312840-jvdph782 85 11 seeking seek VBG cord-312840-jvdph782 85 12 behaviors behavior NNS cord-312840-jvdph782 85 13 by by IN cord-312840-jvdph782 85 14 age age NN cord-312840-jvdph782 85 15 . . . cord-312840-jvdph782 86 1 We -PRON- PRP cord-312840-jvdph782 86 2 smooth smooth VBP cord-312840-jvdph782 86 3 the the DT cord-312840-jvdph782 86 4 distribution distribution NN cord-312840-jvdph782 86 5 of of IN cord-312840-jvdph782 86 6 the the DT cord-312840-jvdph782 86 7 proportion proportion NN cord-312840-jvdph782 86 8 of of IN cord-312840-jvdph782 86 9 cases case NNS cord-312840-jvdph782 86 10 that that WDT cord-312840-jvdph782 86 11 were be VBD cord-312840-jvdph782 86 12 hospitalized hospitalize VBN cord-312840-jvdph782 86 13 by by IN cord-312840-jvdph782 86 14 age age NN cord-312840-jvdph782 86 15 group group NN cord-312840-jvdph782 86 16 to to TO cord-312840-jvdph782 86 17 serve serve VB cord-312840-jvdph782 86 18 as as IN cord-312840-jvdph782 86 19 a a DT cord-312840-jvdph782 86 20 surrogate surrogate JJ cord-312840-jvdph782 86 21 distribution distribution NN cord-312840-jvdph782 86 22 of of IN cord-312840-jvdph782 86 23 healthcare healthcare NN cord-312840-jvdph782 86 24 seeking seek VBG cord-312840-jvdph782 86 25 behavior behavior NN cord-312840-jvdph782 86 26 and/or and/or CC cord-312840-jvdph782 86 27 reporting report VBG cord-312840-jvdph782 86 28 patterns pattern NNS cord-312840-jvdph782 86 29 by by IN cord-312840-jvdph782 86 30 age age NN cord-312840-jvdph782 86 31 . . . cord-312840-jvdph782 87 1 This this DT cord-312840-jvdph782 87 2 distribution distribution NN cord-312840-jvdph782 87 3 is be VBZ cord-312840-jvdph782 87 4 U u NN cord-312840-jvdph782 87 5 - - HYPH cord-312840-jvdph782 87 6 shaped shaped JJ cord-312840-jvdph782 87 7 , , , cord-312840-jvdph782 87 8 indicating indicate VBG cord-312840-jvdph782 87 9 that that IN cord-312840-jvdph782 87 10 the the DT cord-312840-jvdph782 87 11 very very RB cord-312840-jvdph782 87 12 young young JJ cord-312840-jvdph782 87 13 and and CC cord-312840-jvdph782 87 14 very very RB cord-312840-jvdph782 87 15 old old JJ cord-312840-jvdph782 87 16 are be VBP cord-312840-jvdph782 87 17 more more RBR cord-312840-jvdph782 87 18 likely likely JJ cord-312840-jvdph782 87 19 to to TO cord-312840-jvdph782 87 20 seek seek VB cord-312840-jvdph782 87 21 medical medical JJ cord-312840-jvdph782 87 22 care care NN cord-312840-jvdph782 87 23 , , , cord-312840-jvdph782 87 24 a a DT cord-312840-jvdph782 87 25 finding finding NN cord-312840-jvdph782 87 26 that that WDT cord-312840-jvdph782 87 27 has have VBZ cord-312840-jvdph782 87 28 been be VBN cord-312840-jvdph782 87 29 reported report VBN cord-312840-jvdph782 87 30 elsewhere elsewhere RB cord-312840-jvdph782 87 31 [ [ -LRB- cord-312840-jvdph782 87 32 23 23 CD cord-312840-jvdph782 87 33 ] ] -RRB- cord-312840-jvdph782 87 34 . . . cord-312840-jvdph782 88 1 We -PRON- PRP cord-312840-jvdph782 88 2 attach attach VBP cord-312840-jvdph782 88 3 various various JJ cord-312840-jvdph782 88 4 weights weight NNS cord-312840-jvdph782 88 5 to to IN cord-312840-jvdph782 88 6 this this DT cord-312840-jvdph782 88 7 distribution distribution NN cord-312840-jvdph782 88 8 and and CC cord-312840-jvdph782 88 9 augment augment VB cord-312840-jvdph782 88 10 25 25 CD cord-312840-jvdph782 88 11 of of IN cord-312840-jvdph782 88 12 our -PRON- PRP$ cord-312840-jvdph782 88 13 imputed imputed JJ cord-312840-jvdph782 88 14 datasets dataset NNS cord-312840-jvdph782 88 15 according accord VBG cord-312840-jvdph782 88 16 to to IN cord-312840-jvdph782 88 17 this this DT cord-312840-jvdph782 88 18 distribution distribution NN cord-312840-jvdph782 88 19 . . . cord-312840-jvdph782 89 1 We -PRON- PRP cord-312840-jvdph782 89 2 reanalyze reanalyze VBP cord-312840-jvdph782 89 3 this this DT cord-312840-jvdph782 89 4 augmented augment VBN cord-312840-jvdph782 89 5 data datum NNS cord-312840-jvdph782 89 6 to to TO cord-312840-jvdph782 89 7 determine determine VB cord-312840-jvdph782 89 8 the the DT cord-312840-jvdph782 89 9 potential potential JJ cord-312840-jvdph782 89 10 impact impact NN cord-312840-jvdph782 89 11 of of IN cord-312840-jvdph782 89 12 differential differential JJ cord-312840-jvdph782 89 13 case case NN cord-312840-jvdph782 89 14 reporting report VBG cord-312840-jvdph782 89 15 by by IN cord-312840-jvdph782 89 16 age age NN cord-312840-jvdph782 89 17 group group NN cord-312840-jvdph782 89 18 on on IN cord-312840-jvdph782 89 19 the the DT cord-312840-jvdph782 89 20 results result NNS cord-312840-jvdph782 89 21 ( ( -LRB- cord-312840-jvdph782 89 22 Appendix Appendix NNP cord-312840-jvdph782 89 23 3 3 CD cord-312840-jvdph782 89 24 ) ) -RRB- cord-312840-jvdph782 89 25 . . . cord-312840-jvdph782 90 1 Figure figure NN cord-312840-jvdph782 90 2 1 1 CD cord-312840-jvdph782 90 3 provides provide VBZ cord-312840-jvdph782 90 4 the the DT cord-312840-jvdph782 90 5 epidemic epidemic NN cord-312840-jvdph782 90 6 curves curve NNS cord-312840-jvdph782 90 7 across across IN cord-312840-jvdph782 90 8 all all DT cord-312840-jvdph782 90 9 age age NN cord-312840-jvdph782 90 10 groups group NNS cord-312840-jvdph782 90 11 . . . cord-312840-jvdph782 91 1 Here here RB cord-312840-jvdph782 91 2 , , , cord-312840-jvdph782 91 3 school school NN cord-312840-jvdph782 91 4 age age NN cord-312840-jvdph782 91 5 children child NNS cord-312840-jvdph782 91 6 and and CC cord-312840-jvdph782 91 7 young young JJ cord-312840-jvdph782 91 8 adults adult NNS cord-312840-jvdph782 91 9 tend tend VBP cord-312840-jvdph782 91 10 to to TO cord-312840-jvdph782 91 11 have have VB cord-312840-jvdph782 91 12 the the DT cord-312840-jvdph782 91 13 greatest great JJS cord-312840-jvdph782 91 14 number number NN cord-312840-jvdph782 91 15 of of IN cord-312840-jvdph782 91 16 cases case NNS cord-312840-jvdph782 91 17 initially initially RB cord-312840-jvdph782 91 18 in in IN cord-312840-jvdph782 91 19 the the DT cord-312840-jvdph782 91 20 outbreak outbreak NN cord-312840-jvdph782 91 21 . . . cord-312840-jvdph782 92 1 TheR TheR NNP cord-312840-jvdph782 92 2 t t NNP cord-312840-jvdph782 92 3 estimates estimate NNS cord-312840-jvdph782 92 4 are be VBP cord-312840-jvdph782 92 5 similar similar JJ cord-312840-jvdph782 92 6 regardless regardless RB cord-312840-jvdph782 92 7 of of IN cord-312840-jvdph782 92 8 the the DT cord-312840-jvdph782 92 9 type type NN cord-312840-jvdph782 92 10 of of IN cord-312840-jvdph782 92 11 contact contact NN cord-312840-jvdph782 92 12 matrix matrix NN cord-312840-jvdph782 92 13 assumed assume VBD cord-312840-jvdph782 92 14 ( ( -LRB- cord-312840-jvdph782 92 15 close close JJ cord-312840-jvdph782 92 16 contact contact NN cord-312840-jvdph782 92 17 versus versus IN cord-312840-jvdph782 92 18 those those DT cord-312840-jvdph782 92 19 involving involve VBG cord-312840-jvdph782 92 20 physical physical JJ cord-312840-jvdph782 92 21 contact contact NN cord-312840-jvdph782 92 22 ) ) -RRB- cord-312840-jvdph782 92 23 . . . cord-312840-jvdph782 93 1 Overall overall RB cord-312840-jvdph782 93 2 , , , cord-312840-jvdph782 93 3 R r NN cord-312840-jvdph782 93 4 t t NN cord-312840-jvdph782 93 5 is be VBZ cord-312840-jvdph782 93 6 much much RB cord-312840-jvdph782 93 7 higher high JJR cord-312840-jvdph782 93 8 for for IN cord-312840-jvdph782 93 9 those those DT cord-312840-jvdph782 93 10 in in IN cord-312840-jvdph782 93 11 the the DT cord-312840-jvdph782 93 12 15 15 CD cord-312840-jvdph782 93 13 - - SYM cord-312840-jvdph782 93 14 19 19 CD cord-312840-jvdph782 93 15 and and CC cord-312840-jvdph782 93 16 20 20 CD cord-312840-jvdph782 93 17 - - SYM cord-312840-jvdph782 93 18 24 24 CD cord-312840-jvdph782 93 19 year year NN cord-312840-jvdph782 93 20 old old JJ cord-312840-jvdph782 93 21 groups group NNS cord-312840-jvdph782 93 22 throughout throughout IN cord-312840-jvdph782 93 23 much much JJ cord-312840-jvdph782 93 24 of of IN cord-312840-jvdph782 93 25 the the DT cord-312840-jvdph782 93 26 epidemic epidemic NN cord-312840-jvdph782 93 27 , , , cord-312840-jvdph782 93 28 with with IN cord-312840-jvdph782 93 29 the the DT cord-312840-jvdph782 93 30 10 10 CD cord-312840-jvdph782 93 31 - - SYM cord-312840-jvdph782 93 32 14 14 CD cord-312840-jvdph782 93 33 and and CC cord-312840-jvdph782 93 34 25 25 CD cord-312840-jvdph782 93 35 - - SYM cord-312840-jvdph782 93 36 29 29 CD cord-312840-jvdph782 93 37 year year NN cord-312840-jvdph782 93 38 old old JJ cord-312840-jvdph782 93 39 age age NN cord-312840-jvdph782 93 40 groups group NNS cord-312840-jvdph782 93 41 rapidly rapidly RB cord-312840-jvdph782 93 42 achieving achieve VBG cord-312840-jvdph782 93 43 high high JJ cord-312840-jvdph782 93 44 values value NNS cord-312840-jvdph782 93 45 , , , cord-312840-jvdph782 93 46 as as RB cord-312840-jvdph782 93 47 well well RB cord-312840-jvdph782 93 48 . . . cord-312840-jvdph782 94 1 Those those DT cord-312840-jvdph782 94 2 over over IN cord-312840-jvdph782 94 3 45 45 CD cord-312840-jvdph782 94 4 initially initially RB cord-312840-jvdph782 94 5 have have VBP cord-312840-jvdph782 94 6 fairly fairly RB cord-312840-jvdph782 94 7 high high JJ cord-312840-jvdph782 94 8 estimates estimate NNS cord-312840-jvdph782 94 9 ofR ofR VBN cord-312840-jvdph782 94 10 t t NN cord-312840-jvdph782 95 1 but but CC cord-312840-jvdph782 95 2 these these DT cord-312840-jvdph782 95 3 taper taper VBP cord-312840-jvdph782 95 4 off off RP cord-312840-jvdph782 95 5 quickly quickly RB cord-312840-jvdph782 95 6 . . . cord-312840-jvdph782 96 1 Estimates estimate NNS cord-312840-jvdph782 96 2 ofR ofR VBD cord-312840-jvdph782 96 3 t t NN cord-312840-jvdph782 96 4 are be VBP cord-312840-jvdph782 96 5 not not RB cord-312840-jvdph782 96 6 obtainable obtainable JJ cord-312840-jvdph782 96 7 for for IN cord-312840-jvdph782 96 8 those those DT cord-312840-jvdph782 96 9 between between IN cord-312840-jvdph782 96 10 5 5 CD cord-312840-jvdph782 96 11 and and CC cord-312840-jvdph782 96 12 9 9 CD cord-312840-jvdph782 96 13 and and CC cord-312840-jvdph782 96 14 those those DT cord-312840-jvdph782 96 15 less less JJR cord-312840-jvdph782 96 16 than than IN cord-312840-jvdph782 96 17 5 5 CD cord-312840-jvdph782 96 18 until until IN cord-312840-jvdph782 96 19 the the DT cord-312840-jvdph782 96 20 outbreak outbreak NN cord-312840-jvdph782 96 21 is be VBZ cord-312840-jvdph782 96 22 well well RB cord-312840-jvdph782 96 23 under under IN cord-312840-jvdph782 96 24 way way NN cord-312840-jvdph782 96 25 , , , cord-312840-jvdph782 96 26 due due IN cord-312840-jvdph782 96 27 to to IN cord-312840-jvdph782 96 28 the the DT cord-312840-jvdph782 96 29 paucity paucity NN cord-312840-jvdph782 96 30 of of IN cord-312840-jvdph782 96 31 observed observed JJ cord-312840-jvdph782 96 32 cases case NNS cord-312840-jvdph782 96 33 for for IN cord-312840-jvdph782 96 34 those those DT cord-312840-jvdph782 96 35 age age NN cord-312840-jvdph782 96 36 groups group NNS cord-312840-jvdph782 96 37 early early RB cord-312840-jvdph782 96 38 on on RB cord-312840-jvdph782 96 39 in in IN cord-312840-jvdph782 96 40 the the DT cord-312840-jvdph782 96 41 epidemic epidemic NN cord-312840-jvdph782 96 42 . . . cord-312840-jvdph782 97 1 We -PRON- PRP cord-312840-jvdph782 97 2 obtain obtain VBP cord-312840-jvdph782 97 3 estimates estimate NNS cord-312840-jvdph782 97 4 of of IN cord-312840-jvdph782 97 5 R r NN cord-312840-jvdph782 97 6 0 0 CD cord-312840-jvdph782 97 7 , , , cord-312840-jvdph782 97 8 the the DT cord-312840-jvdph782 97 9 basic basic JJ cord-312840-jvdph782 97 10 reproductive reproductive JJ cord-312840-jvdph782 97 11 number number NN cord-312840-jvdph782 97 12 , , , cord-312840-jvdph782 97 13 by by IN cord-312840-jvdph782 97 14 averaging average VBG cord-312840-jvdph782 97 15 the the DT cord-312840-jvdph782 97 16 estimates estimate NNS cord-312840-jvdph782 97 17 of of IN cord-312840-jvdph782 97 18 R R NNP cord-312840-jvdph782 97 19 t t NN cord-312840-jvdph782 97 20 during during IN cord-312840-jvdph782 97 21 the the DT cord-312840-jvdph782 97 22 epidemic epidemic NN cord-312840-jvdph782 97 23 period period NN cord-312840-jvdph782 97 24 . . . cord-312840-jvdph782 98 1 In in IN cord-312840-jvdph782 98 2 reality reality NN cord-312840-jvdph782 98 3 this this DT cord-312840-jvdph782 98 4 can can MD cord-312840-jvdph782 98 5 be be VB cord-312840-jvdph782 98 6 viewed view VBN cord-312840-jvdph782 98 7 as as IN cord-312840-jvdph782 98 8 a a DT cord-312840-jvdph782 98 9 pseudo pseudo JJ cord-312840-jvdph782 98 10 - - HYPH cord-312840-jvdph782 98 11 R r JJ cord-312840-jvdph782 98 12 0 0 CD cord-312840-jvdph782 98 13 given give VBN cord-312840-jvdph782 98 14 the the DT cord-312840-jvdph782 98 15 prior prior JJ cord-312840-jvdph782 98 16 immunity immunity NN cord-312840-jvdph782 98 17 to to IN cord-312840-jvdph782 98 18 this this DT cord-312840-jvdph782 98 19 strain strain NN cord-312840-jvdph782 98 20 of of IN cord-312840-jvdph782 98 21 influenza influenza NN cord-312840-jvdph782 98 22 . . . cord-312840-jvdph782 99 1 We -PRON- PRP cord-312840-jvdph782 99 2 will will MD cord-312840-jvdph782 99 3 refer refer VB cord-312840-jvdph782 99 4 to to IN cord-312840-jvdph782 99 5 it -PRON- PRP cord-312840-jvdph782 99 6 as as IN cord-312840-jvdph782 99 7 R r NN cord-312840-jvdph782 99 8 0 0 NFP cord-312840-jvdph782 99 9 throughout throughout IN cord-312840-jvdph782 99 10 the the DT cord-312840-jvdph782 99 11 text text NN cord-312840-jvdph782 99 12 . . . cord-312840-jvdph782 100 1 We -PRON- PRP cord-312840-jvdph782 100 2 assume assume VBP cord-312840-jvdph782 100 3 that that IN cord-312840-jvdph782 100 4 the the DT cord-312840-jvdph782 100 5 epidemic epidemic NN cord-312840-jvdph782 100 6 period period NN cord-312840-jvdph782 100 7 corresponds correspond VBZ cord-312840-jvdph782 100 8 to to IN cord-312840-jvdph782 100 9 the the DT cord-312840-jvdph782 100 10 point point NN cord-312840-jvdph782 100 11 at at IN cord-312840-jvdph782 100 12 which which WDT cord-312840-jvdph782 100 13 transmission transmission NN cord-312840-jvdph782 100 14 was be VBD cord-312840-jvdph782 100 15 sustained sustain VBN cord-312840-jvdph782 100 16 in in IN cord-312840-jvdph782 100 17 Gauteng Gauteng NNP cord-312840-jvdph782 100 18 Province Province NNP cord-312840-jvdph782 100 19 until until IN cord-312840-jvdph782 100 20 the the DT cord-312840-jvdph782 100 21 overall overall JJ cord-312840-jvdph782 100 22 number number NN cord-312840-jvdph782 100 23 of of IN cord-312840-jvdph782 100 24 cases case NNS cord-312840-jvdph782 100 25 peaked peak VBD cord-312840-jvdph782 100 26 . . . cord-312840-jvdph782 101 1 This this DT cord-312840-jvdph782 101 2 corresponds correspond VBZ cord-312840-jvdph782 101 3 to to IN cord-312840-jvdph782 101 4 the the DT cord-312840-jvdph782 101 5 period period NN cord-312840-jvdph782 101 6 between between IN cord-312840-jvdph782 101 7 22 22 CD cord-312840-jvdph782 101 8 June June NNP cord-312840-jvdph782 101 9 2009 2009 CD cord-312840-jvdph782 101 10 and and CC cord-312840-jvdph782 101 11 21 21 CD cord-312840-jvdph782 101 12 August August NNP cord-312840-jvdph782 101 13 2009 2009 CD cord-312840-jvdph782 101 14 . . . cord-312840-jvdph782 102 1 Figure figure NN cord-312840-jvdph782 102 2 3 3 CD cord-312840-jvdph782 102 3 and and CC cord-312840-jvdph782 102 4 Table Table NNP cord-312840-jvdph782 102 5 1 1 CD cord-312840-jvdph782 102 6 show show VBP cord-312840-jvdph782 102 7 the the DT cord-312840-jvdph782 102 8 estimates estimate NNS cord-312840-jvdph782 102 9 of of IN cord-312840-jvdph782 102 10 R r NN cord-312840-jvdph782 102 11 0 0 CD cord-312840-jvdph782 102 12 across across IN cord-312840-jvdph782 102 13 age age NN cord-312840-jvdph782 102 14 groups group NNS cord-312840-jvdph782 102 15 along along IN cord-312840-jvdph782 102 16 with with IN cord-312840-jvdph782 102 17 the the DT cord-312840-jvdph782 102 18 number number NN cord-312840-jvdph782 102 19 of of IN cord-312840-jvdph782 102 20 individuals individual NNS cord-312840-jvdph782 102 21 in in IN cord-312840-jvdph782 102 22 each each DT cord-312840-jvdph782 102 23 age age NN cord-312840-jvdph782 102 24 group group NN cord-312840-jvdph782 102 25 who who WP cord-312840-jvdph782 102 26 were be VBD cord-312840-jvdph782 102 27 reported report VBN cord-312840-jvdph782 102 28 infected infect VBN cord-312840-jvdph782 102 29 throughout throughout IN cord-312840-jvdph782 102 30 the the DT cord-312840-jvdph782 102 31 epidemic epidemic NN cord-312840-jvdph782 102 32 . . . cord-312840-jvdph782 103 1 Regardless regardless RB cord-312840-jvdph782 103 2 of of IN cord-312840-jvdph782 103 3 the the DT cord-312840-jvdph782 103 4 choice choice NN cord-312840-jvdph782 103 5 of of IN cord-312840-jvdph782 103 6 matrix matrix NN cord-312840-jvdph782 103 7 , , , cord-312840-jvdph782 103 8 supercritical supercritical JJ cord-312840-jvdph782 103 9 values value NNS cord-312840-jvdph782 103 10 of of IN cord-312840-jvdph782 103 11 R r NN cord-312840-jvdph782 103 12 0 0 CD cord-312840-jvdph782 103 13 are be VBP cord-312840-jvdph782 103 14 obtained obtain VBN cord-312840-jvdph782 103 15 for for IN cord-312840-jvdph782 103 16 those those DT cord-312840-jvdph782 103 17 between between IN cord-312840-jvdph782 103 18 the the DT cord-312840-jvdph782 103 19 age age NN cord-312840-jvdph782 103 20 of of IN cord-312840-jvdph782 103 21 5 5 CD cord-312840-jvdph782 103 22 and and CC cord-312840-jvdph782 103 23 24 24 CD cord-312840-jvdph782 103 24 , , , cord-312840-jvdph782 103 25 with with IN cord-312840-jvdph782 103 26 the the DT cord-312840-jvdph782 103 27 highest high JJS cord-312840-jvdph782 103 28 values value NNS cord-312840-jvdph782 103 29 being be VBG cord-312840-jvdph782 103 30 observed observe VBN cord-312840-jvdph782 103 31 for for IN cord-312840-jvdph782 103 32 those those DT cord-312840-jvdph782 103 33 in in IN cord-312840-jvdph782 103 34 the the DT cord-312840-jvdph782 103 35 10 10 CD cord-312840-jvdph782 103 36 - - SYM cord-312840-jvdph782 103 37 14 14 CD cord-312840-jvdph782 103 38 age age NN cord-312840-jvdph782 103 39 - - HYPH cord-312840-jvdph782 103 40 group group NN cord-312840-jvdph782 103 41 ( ( -LRB- cord-312840-jvdph782 103 42 R r NN cord-312840-jvdph782 103 43 0 0 CD cord-312840-jvdph782 103 44 = = SYM cord-312840-jvdph782 103 45 1.53 1.53 CD cord-312840-jvdph782 103 46 for for IN cord-312840-jvdph782 103 47 close close JJ cord-312840-jvdph782 103 48 contacts contact NNS cord-312840-jvdph782 103 49 ) ) -RRB- cord-312840-jvdph782 103 50 . . . cord-312840-jvdph782 104 1 We -PRON- PRP cord-312840-jvdph782 104 2 contrast contrast VBP cord-312840-jvdph782 104 3 these these DT cord-312840-jvdph782 104 4 estimates estimate NNS cord-312840-jvdph782 104 5 with with IN cord-312840-jvdph782 104 6 those those DT cord-312840-jvdph782 104 7 obtained obtain VBN cord-312840-jvdph782 104 8 using use VBG cord-312840-jvdph782 104 9 contact contact NN cord-312840-jvdph782 104 10 matrices matrix NNS cord-312840-jvdph782 104 11 from from IN cord-312840-jvdph782 104 12 Europe Europe NNP cord-312840-jvdph782 104 13 [ [ -LRB- cord-312840-jvdph782 104 14 5 5 CD cord-312840-jvdph782 104 15 ] ] -RRB- cord-312840-jvdph782 104 16 . . . cord-312840-jvdph782 105 1 Figures figure NNS cord-312840-jvdph782 105 2 3a 3a NNP cord-312840-jvdph782 105 3 and and CC cord-312840-jvdph782 105 4 3b 3b NNP cord-312840-jvdph782 105 5 shows show VBZ cord-312840-jvdph782 105 6 the the DT cord-312840-jvdph782 105 7 estimates estimate NNS cord-312840-jvdph782 105 8 of of IN cord-312840-jvdph782 105 9 R r NN cord-312840-jvdph782 105 10 0 0 CD cord-312840-jvdph782 105 11 across across IN cord-312840-jvdph782 105 12 the the DT cord-312840-jvdph782 105 13 10 10 CD cord-312840-jvdph782 105 14 age age NN cord-312840-jvdph782 105 15 groups group NNS cord-312840-jvdph782 105 16 obtained obtain VBD cord-312840-jvdph782 105 17 when when WRB cord-312840-jvdph782 105 18 using use VBG cord-312840-jvdph782 105 19 contact contact NN cord-312840-jvdph782 105 20 patterns pattern NNS cord-312840-jvdph782 105 21 from from IN cord-312840-jvdph782 105 22 South South NNP cord-312840-jvdph782 105 23 Africa Africa NNP cord-312840-jvdph782 105 24 and and CC cord-312840-jvdph782 105 25 the the DT cord-312840-jvdph782 105 26 eight eight CD cord-312840-jvdph782 105 27 European european JJ cord-312840-jvdph782 105 28 countries country NNS cord-312840-jvdph782 105 29 in in IN cord-312840-jvdph782 105 30 the the DT cord-312840-jvdph782 105 31 PolyMod PolyMod NNP cord-312840-jvdph782 105 32 study study NN cord-312840-jvdph782 105 33 for for IN cord-312840-jvdph782 105 34 all all DT cord-312840-jvdph782 105 35 close close JJ cord-312840-jvdph782 105 36 contacts contact NNS cord-312840-jvdph782 105 37 ( ( -LRB- cord-312840-jvdph782 105 38 Figure figure NN cord-312840-jvdph782 105 39 3a 3a CD cord-312840-jvdph782 105 40 ) ) -RRB- cord-312840-jvdph782 105 41 and and CC cord-312840-jvdph782 105 42 all all DT cord-312840-jvdph782 105 43 contacts contact NNS cord-312840-jvdph782 105 44 involving involve VBG cord-312840-jvdph782 105 45 physical physical JJ cord-312840-jvdph782 105 46 touch touch NN cord-312840-jvdph782 105 47 ( ( -LRB- cord-312840-jvdph782 105 48 Figure figure NN cord-312840-jvdph782 105 49 3b 3b CD cord-312840-jvdph782 105 50 ) ) -RRB- cord-312840-jvdph782 105 51 . . . cord-312840-jvdph782 106 1 There there EX cord-312840-jvdph782 106 2 are be VBP cord-312840-jvdph782 106 3 few few JJ cord-312840-jvdph782 106 4 notable notable JJ cord-312840-jvdph782 106 5 differences difference NNS cord-312840-jvdph782 106 6 between between IN cord-312840-jvdph782 106 7 the the DT cord-312840-jvdph782 106 8 estimates estimate NNS cord-312840-jvdph782 106 9 . . . cord-312840-jvdph782 107 1 In in IN cord-312840-jvdph782 107 2 Figure Figure NNP cord-312840-jvdph782 107 3 4 4 CD cord-312840-jvdph782 107 4 , , , cord-312840-jvdph782 107 5 the the DT cord-312840-jvdph782 107 6 mean mean JJ cord-312840-jvdph782 107 7 estimates estimate NNS cord-312840-jvdph782 107 8 of of IN cord-312840-jvdph782 107 9 R r NN cord-312840-jvdph782 107 10 0 0 CD cord-312840-jvdph782 107 11 are be VBP cord-312840-jvdph782 107 12 shown show VBN cord-312840-jvdph782 107 13 for for IN cord-312840-jvdph782 107 14 each each DT cord-312840-jvdph782 107 15 age age NN cord-312840-jvdph782 107 16 group group NN cord-312840-jvdph782 107 17 . . . cord-312840-jvdph782 108 1 We -PRON- PRP cord-312840-jvdph782 108 2 observe observe VBP cord-312840-jvdph782 108 3 a a DT cord-312840-jvdph782 108 4 similar similar JJ cord-312840-jvdph782 108 5 overall overall JJ cord-312840-jvdph782 108 6 trend trend NN cord-312840-jvdph782 108 7 for for IN cord-312840-jvdph782 108 8 the the DT cord-312840-jvdph782 108 9 estimate estimate NN cord-312840-jvdph782 108 10 of of IN cord-312840-jvdph782 108 11 R r NN cord-312840-jvdph782 108 12 0 0 CD cord-312840-jvdph782 108 13 across across IN cord-312840-jvdph782 108 14 the the DT cord-312840-jvdph782 108 15 age age NN cord-312840-jvdph782 108 16 groups group NNS cord-312840-jvdph782 108 17 . . . cord-312840-jvdph782 109 1 Finally finally RB cord-312840-jvdph782 109 2 we -PRON- PRP cord-312840-jvdph782 109 3 provide provide VBP cord-312840-jvdph782 109 4 the the DT cord-312840-jvdph782 109 5 overall overall JJ cord-312840-jvdph782 109 6 estimate estimate NN cord-312840-jvdph782 109 7 of of IN cord-312840-jvdph782 109 8 R r NN cord-312840-jvdph782 109 9 0 0 CD cord-312840-jvdph782 109 10 collapsed collapse VBD cord-312840-jvdph782 109 11 over over IN cord-312840-jvdph782 109 12 all all DT cord-312840-jvdph782 109 13 age age NN cord-312840-jvdph782 109 14 groups group NNS cord-312840-jvdph782 109 15 ( ( -LRB- cord-312840-jvdph782 109 16 Table table NN cord-312840-jvdph782 109 17 2 2 CD cord-312840-jvdph782 109 18 ) ) -RRB- cord-312840-jvdph782 109 19 . . . cord-312840-jvdph782 110 1 For for IN cord-312840-jvdph782 110 2 comparison comparison NN cord-312840-jvdph782 110 3 purposes purpose NNS cord-312840-jvdph782 110 4 , , , cord-312840-jvdph782 110 5 we -PRON- PRP cord-312840-jvdph782 110 6 first first RB cord-312840-jvdph782 110 7 estimate estimate VBP cord-312840-jvdph782 110 8 R r NN cord-312840-jvdph782 110 9 0 0 CD cord-312840-jvdph782 110 10 by by IN cord-312840-jvdph782 110 11 using use VBG cord-312840-jvdph782 110 12 a a DT cord-312840-jvdph782 110 13 traditional traditional JJ cord-312840-jvdph782 110 14 analysis analysis NN cord-312840-jvdph782 110 15 that that WDT cord-312840-jvdph782 110 16 assumes assume VBZ cord-312840-jvdph782 110 17 homogenous homogenous JJ cord-312840-jvdph782 110 18 mixing mixing NN cord-312840-jvdph782 110 19 among among IN cord-312840-jvdph782 110 20 the the DT cord-312840-jvdph782 110 21 age age NN cord-312840-jvdph782 110 22 groups group NNS cord-312840-jvdph782 110 23 ( ( -LRB- cord-312840-jvdph782 110 24 R r NN cord-312840-jvdph782 110 25 0 0 CD cord-312840-jvdph782 110 26 = = SYM cord-312840-jvdph782 110 27 1.28 1.28 CD cord-312840-jvdph782 110 28 , , , cord-312840-jvdph782 110 29 range range NN cord-312840-jvdph782 110 30 : : : cord-312840-jvdph782 110 31 1.26 1.26 CD cord-312840-jvdph782 110 32 - - HYPH cord-312840-jvdph782 110 33 1.31 1.31 CD cord-312840-jvdph782 110 34 ) ) -RRB- cord-312840-jvdph782 110 35 . . . cord-312840-jvdph782 111 1 This this DT cord-312840-jvdph782 111 2 is be VBZ cord-312840-jvdph782 111 3 similar similar JJ cord-312840-jvdph782 111 4 to to IN cord-312840-jvdph782 111 5 that that DT cord-312840-jvdph782 111 6 obtained obtain VBN cord-312840-jvdph782 111 7 for for IN cord-312840-jvdph782 111 8 all all PDT cord-312840-jvdph782 111 9 the the DT cord-312840-jvdph782 111 10 other other JJ cord-312840-jvdph782 111 11 contact contact NN cord-312840-jvdph782 111 12 matrices matrix NNS cord-312840-jvdph782 111 13 considered consider VBN cord-312840-jvdph782 111 14 . . . cord-312840-jvdph782 112 1 Additionally additionally RB cord-312840-jvdph782 112 2 there there EX cord-312840-jvdph782 112 3 are be VBP cord-312840-jvdph782 112 4 virtually virtually RB cord-312840-jvdph782 112 5 no no DT cord-312840-jvdph782 112 6 differences difference NNS cord-312840-jvdph782 112 7 observed observe VBN cord-312840-jvdph782 112 8 between between IN cord-312840-jvdph782 112 9 results result NNS cord-312840-jvdph782 112 10 from from IN cord-312840-jvdph782 112 11 the the DT cord-312840-jvdph782 112 12 two two CD cord-312840-jvdph782 112 13 contact contact NN cord-312840-jvdph782 112 14 matrices matrix NNS cord-312840-jvdph782 112 15 . . . cord-312840-jvdph782 113 1 Our -PRON- PRP$ cord-312840-jvdph782 113 2 first first JJ cord-312840-jvdph782 113 3 sensitivity sensitivity NN cord-312840-jvdph782 113 4 analysis analysis NN cord-312840-jvdph782 113 5 , , , cord-312840-jvdph782 113 6 which which WDT cord-312840-jvdph782 113 7 jitters jitter VBZ cord-312840-jvdph782 113 8 the the DT cord-312840-jvdph782 113 9 onset onset NN cord-312840-jvdph782 113 10 dates date NNS cord-312840-jvdph782 113 11 of of IN cord-312840-jvdph782 113 12 a a DT cord-312840-jvdph782 113 13 subset subset NN cord-312840-jvdph782 113 14 of of IN cord-312840-jvdph782 113 15 the the DT cord-312840-jvdph782 113 16 population population NN cord-312840-jvdph782 113 17 , , , cord-312840-jvdph782 113 18 ( ( -LRB- cord-312840-jvdph782 113 19 Additional additional JJ cord-312840-jvdph782 113 20 file file NN cord-312840-jvdph782 113 21 1 1 CD cord-312840-jvdph782 113 22 : : : cord-312840-jvdph782 113 23 Table Table NNP cord-312840-jvdph782 113 24 S1 S1 NNP cord-312840-jvdph782 113 25 ) ) -RRB- cord-312840-jvdph782 113 26 provides provide VBZ cord-312840-jvdph782 113 27 results result NNS cord-312840-jvdph782 113 28 that that WDT cord-312840-jvdph782 113 29 are be VBP cord-312840-jvdph782 113 30 consistent consistent JJ cord-312840-jvdph782 113 31 with with IN cord-312840-jvdph782 113 32 the the DT cord-312840-jvdph782 113 33 results result NNS cord-312840-jvdph782 113 34 presented present VBN cord-312840-jvdph782 113 35 . . . cord-312840-jvdph782 114 1 Not not RB cord-312840-jvdph782 114 2 surprisingly surprisingly RB cord-312840-jvdph782 114 3 , , , cord-312840-jvdph782 114 4 the the DT cord-312840-jvdph782 114 5 impact impact NN cord-312840-jvdph782 114 6 of of IN cord-312840-jvdph782 114 7 reassigning reassign VBG cord-312840-jvdph782 114 8 onset onset NN cord-312840-jvdph782 114 9 dates date NNS cord-312840-jvdph782 114 10 to to IN cord-312840-jvdph782 114 11 a a DT cord-312840-jvdph782 114 12 portion portion NN cord-312840-jvdph782 114 13 of of IN cord-312840-jvdph782 114 14 the the DT cord-312840-jvdph782 114 15 dataset dataset NN cord-312840-jvdph782 114 16 has have VBZ cord-312840-jvdph782 114 17 the the DT cord-312840-jvdph782 114 18 impact impact NN cord-312840-jvdph782 114 19 of of IN cord-312840-jvdph782 114 20 flattening flatten VBG cord-312840-jvdph782 114 21 the the DT cord-312840-jvdph782 114 22 epidemic epidemic NN cord-312840-jvdph782 114 23 curve curve NN cord-312840-jvdph782 114 24 and and CC cord-312840-jvdph782 114 25 thus thus RB cord-312840-jvdph782 114 26 lowering lower VBG cord-312840-jvdph782 114 27 the the DT cord-312840-jvdph782 114 28 estimates estimate NNS cord-312840-jvdph782 114 29 of of IN cord-312840-jvdph782 114 30 R r NN cord-312840-jvdph782 114 31 0 0 CD cord-312840-jvdph782 114 32 . . . cord-312840-jvdph782 115 1 However however RB cord-312840-jvdph782 115 2 the the DT cord-312840-jvdph782 115 3 results result NNS cord-312840-jvdph782 115 4 remain remain VBP cord-312840-jvdph782 115 5 consistent consistent JJ cord-312840-jvdph782 115 6 and and CC cord-312840-jvdph782 115 7 , , , cord-312840-jvdph782 115 8 coupled couple VBN cord-312840-jvdph782 115 9 with with IN cord-312840-jvdph782 115 10 the the DT cord-312840-jvdph782 115 11 imputation imputation NN cord-312840-jvdph782 115 12 variability variability NN cord-312840-jvdph782 115 13 reported report VBN cord-312840-jvdph782 115 14 , , , cord-312840-jvdph782 115 15 provide provide VB cord-312840-jvdph782 115 16 insight insight NN cord-312840-jvdph782 115 17 on on IN cord-312840-jvdph782 115 18 the the DT cord-312840-jvdph782 115 19 overall overall JJ cord-312840-jvdph782 115 20 variability variability NN cord-312840-jvdph782 115 21 of of IN cord-312840-jvdph782 115 22 the the DT cord-312840-jvdph782 115 23 estimates estimate NNS cord-312840-jvdph782 115 24 reported report VBN cord-312840-jvdph782 115 25 . . . cord-312840-jvdph782 116 1 In in IN cord-312840-jvdph782 116 2 our -PRON- PRP$ cord-312840-jvdph782 116 3 second second JJ cord-312840-jvdph782 116 4 sensitivity sensitivity NN cord-312840-jvdph782 116 5 analysis analysis NN cord-312840-jvdph782 116 6 ( ( -LRB- cord-312840-jvdph782 116 7 Additional additional JJ cord-312840-jvdph782 116 8 file file NN cord-312840-jvdph782 116 9 2 2 CD cord-312840-jvdph782 116 10 : : : cord-312840-jvdph782 116 11 Table table NN cord-312840-jvdph782 116 12 S2 S2 NNP cord-312840-jvdph782 116 13 and and CC cord-312840-jvdph782 116 14 Additional additional JJ cord-312840-jvdph782 116 15 file file NN cord-312840-jvdph782 116 16 3 3 CD cord-312840-jvdph782 116 17 : : : cord-312840-jvdph782 116 18 Figure figure NN cord-312840-jvdph782 116 19 S1 S1 NNP cord-312840-jvdph782 116 20 ) ) -RRB- cord-312840-jvdph782 116 21 , , , cord-312840-jvdph782 116 22 examining examine VBG cord-312840-jvdph782 116 23 the the DT cord-312840-jvdph782 116 24 potential potential JJ cord-312840-jvdph782 116 25 impact impact NN cord-312840-jvdph782 116 26 of of IN cord-312840-jvdph782 116 27 differential differential JJ cord-312840-jvdph782 116 28 reporting reporting NN cord-312840-jvdph782 116 29 by by IN cord-312840-jvdph782 116 30 age age NN cord-312840-jvdph782 116 31 , , , cord-312840-jvdph782 116 32 we -PRON- PRP cord-312840-jvdph782 116 33 note note VBP cord-312840-jvdph782 116 34 a a DT cord-312840-jvdph782 116 35 Page page NN cord-312840-jvdph782 116 36 5 5 CD cord-312840-jvdph782 116 37 of of IN cord-312840-jvdph782 116 38 10 10 CD cord-312840-jvdph782 116 39 http://www.ete-online.com/content/11/1/4 http://www.ete-online.com/content/11/1/4 JJ cord-312840-jvdph782 116 40 dramatic dramatic JJ cord-312840-jvdph782 116 41 impact impact NN cord-312840-jvdph782 116 42 on on IN cord-312840-jvdph782 116 43 the the DT cord-312840-jvdph782 116 44 results result NNS cord-312840-jvdph782 116 45 . . . cord-312840-jvdph782 117 1 As as IN cord-312840-jvdph782 117 2 we -PRON- PRP cord-312840-jvdph782 117 3 assume assume VBP cord-312840-jvdph782 117 4 a a DT cord-312840-jvdph782 117 5 greater great JJR cord-312840-jvdph782 117 6 underreporting underreporting NN cord-312840-jvdph782 117 7 of of IN cord-312840-jvdph782 117 8 cases case NNS cord-312840-jvdph782 117 9 among among IN cord-312840-jvdph782 117 10 those those DT cord-312840-jvdph782 117 11 who who WP cord-312840-jvdph782 117 12 are be VBP cord-312840-jvdph782 117 13 middle middle JJ cord-312840-jvdph782 117 14 aged aged JJ cord-312840-jvdph782 117 15 , , , cord-312840-jvdph782 117 16 we -PRON- PRP cord-312840-jvdph782 117 17 estimate estimate VBP cord-312840-jvdph782 117 18 the the DT cord-312840-jvdph782 117 19 bulk bulk NN cord-312840-jvdph782 117 20 of of IN cord-312840-jvdph782 117 21 transmission transmission NN cord-312840-jvdph782 117 22 being be VBG cord-312840-jvdph782 117 23 attributable attributable JJ cord-312840-jvdph782 117 24 to to IN cord-312840-jvdph782 117 25 those those DT cord-312840-jvdph782 117 26 who who WP cord-312840-jvdph782 117 27 are be VBP cord-312840-jvdph782 117 28 older old JJR cord-312840-jvdph782 117 29 and and CC cord-312840-jvdph782 117 30 less less JJR cord-312840-jvdph782 117 31 transmission transmission NN cord-312840-jvdph782 117 32 being be VBG cord-312840-jvdph782 117 33 attributed attribute VBN cord-312840-jvdph782 117 34 to to IN cord-312840-jvdph782 117 35 the the DT cord-312840-jvdph782 117 36 very very RB cord-312840-jvdph782 117 37 young young JJ cord-312840-jvdph782 117 38 , , , cord-312840-jvdph782 117 39 a a DT cord-312840-jvdph782 117 40 finding finding NN cord-312840-jvdph782 117 41 contrary contrary JJ cord-312840-jvdph782 117 42 to to IN cord-312840-jvdph782 117 43 the the DT cord-312840-jvdph782 117 44 original original JJ cord-312840-jvdph782 117 45 results result NNS cord-312840-jvdph782 117 46 we -PRON- PRP cord-312840-jvdph782 117 47 present present VBP cord-312840-jvdph782 117 48 . . . cord-312840-jvdph782 118 1 We -PRON- PRP cord-312840-jvdph782 118 2 present present VBP cord-312840-jvdph782 118 3 a a DT cord-312840-jvdph782 118 4 novel novel JJ cord-312840-jvdph782 118 5 approach approach NN cord-312840-jvdph782 118 6 to to IN cord-312840-jvdph782 118 7 estimating estimate VBG cord-312840-jvdph782 118 8 the the DT cord-312840-jvdph782 118 9 effective effective JJ cord-312840-jvdph782 118 10 and and CC cord-312840-jvdph782 118 11 basic basic JJ cord-312840-jvdph782 118 12 reproductive reproductive JJ cord-312840-jvdph782 118 13 number number NN cord-312840-jvdph782 118 14 by by IN cord-312840-jvdph782 118 15 age age NN cord-312840-jvdph782 118 16 group group NN cord-312840-jvdph782 118 17 , , , cord-312840-jvdph782 118 18 and and CC cord-312840-jvdph782 118 19 have have VBP cord-312840-jvdph782 118 20 applied apply VBN cord-312840-jvdph782 118 21 this this DT cord-312840-jvdph782 118 22 method method NN cord-312840-jvdph782 118 23 to to IN cord-312840-jvdph782 118 24 data datum NNS cord-312840-jvdph782 118 25 from from IN cord-312840-jvdph782 118 26 the the DT cord-312840-jvdph782 118 27 2009 2009 CD cord-312840-jvdph782 118 28 Influenza Influenza NNP cord-312840-jvdph782 118 29 H1N1pdm H1N1pdm NNP cord-312840-jvdph782 118 30 in in IN cord-312840-jvdph782 118 31 Gauteng Gauteng NNP cord-312840-jvdph782 118 32 Province Province NNP cord-312840-jvdph782 118 33 in in IN cord-312840-jvdph782 118 34 South South NNP cord-312840-jvdph782 118 35 Africa Africa NNP cord-312840-jvdph782 118 36 . . . cord-312840-jvdph782 119 1 This this DT cord-312840-jvdph782 119 2 method method NN cord-312840-jvdph782 119 3 requires require VBZ cord-312840-jvdph782 119 4 some some DT cord-312840-jvdph782 119 5 estimate estimate NN cord-312840-jvdph782 119 6 of of IN cord-312840-jvdph782 119 7 contact contact NN cord-312840-jvdph782 119 8 patterns pattern NNS cord-312840-jvdph782 119 9 between between IN cord-312840-jvdph782 119 10 age age NN cord-312840-jvdph782 119 11 groups group NNS cord-312840-jvdph782 119 12 . . . cord-312840-jvdph782 120 1 We -PRON- PRP cord-312840-jvdph782 120 2 show show VBP cord-312840-jvdph782 120 3 results result NNS cord-312840-jvdph782 120 4 for for IN cord-312840-jvdph782 120 5 18 18 CD cord-312840-jvdph782 120 6 different different JJ cord-312840-jvdph782 120 7 possible possible JJ cord-312840-jvdph782 120 8 contact contact NN cord-312840-jvdph782 120 9 matrices matrix NNS cord-312840-jvdph782 120 10 and and CC cord-312840-jvdph782 120 11 the the DT cord-312840-jvdph782 120 12 impact impact NN cord-312840-jvdph782 120 13 that that WDT cord-312840-jvdph782 120 14 these these DT cord-312840-jvdph782 120 15 matrices matrix NNS cord-312840-jvdph782 120 16 have have VBP cord-312840-jvdph782 120 17 on on IN cord-312840-jvdph782 120 18 the the DT cord-312840-jvdph782 120 19 estimates estimate NNS cord-312840-jvdph782 120 20 . . . cord-312840-jvdph782 121 1 Additionally additionally RB cord-312840-jvdph782 121 2 , , , cord-312840-jvdph782 121 3 as as IN cord-312840-jvdph782 121 4 with with IN cord-312840-jvdph782 121 5 the the DT cord-312840-jvdph782 121 6 original original JJ cord-312840-jvdph782 121 7 method method NN cord-312840-jvdph782 121 8 proposed propose VBN cord-312840-jvdph782 121 9 by by IN cord-312840-jvdph782 121 10 Wallinga Wallinga NNP cord-312840-jvdph782 121 11 and and CC cord-312840-jvdph782 121 12 Teunis Teunis NNP cord-312840-jvdph782 121 13 [ [ -LRB- cord-312840-jvdph782 121 14 20 20 CD cord-312840-jvdph782 121 15 ] ] -RRB- cord-312840-jvdph782 121 16 , , , cord-312840-jvdph782 121 17 it -PRON- PRP cord-312840-jvdph782 121 18 is be VBZ cord-312840-jvdph782 121 19 necessary necessary JJ cord-312840-jvdph782 121 20 to to TO cord-312840-jvdph782 121 21 have have VB cord-312840-jvdph782 121 22 an an DT cord-312840-jvdph782 121 23 estimate estimate NN cord-312840-jvdph782 121 24 of of IN cord-312840-jvdph782 121 25 the the DT cord-312840-jvdph782 121 26 serial serial JJ cord-312840-jvdph782 121 27 interval interval NN cord-312840-jvdph782 121 28 and and CC cord-312840-jvdph782 121 29 we -PRON- PRP cord-312840-jvdph782 121 30 use use VBP cord-312840-jvdph782 121 31 an an DT cord-312840-jvdph782 121 32 estimate estimate NN cord-312840-jvdph782 121 33 obtained obtain VBN cord-312840-jvdph782 121 34 from from IN cord-312840-jvdph782 121 35 contact contact NN cord-312840-jvdph782 121 36 trace trace NN cord-312840-jvdph782 121 37 data datum NNS cord-312840-jvdph782 121 38 in in IN cord-312840-jvdph782 121 39 South South NNP cord-312840-jvdph782 121 40 Africa Africa NNP cord-312840-jvdph782 121 41 . . . cord-312840-jvdph782 122 1 As as IN cord-312840-jvdph782 122 2 has have VBZ cord-312840-jvdph782 122 3 been be VBN cord-312840-jvdph782 122 4 previously previously RB cord-312840-jvdph782 122 5 noted note VBN cord-312840-jvdph782 122 6 , , , cord-312840-jvdph782 122 7 that that IN cord-312840-jvdph782 122 8 the the DT cord-312840-jvdph782 122 9 burden burden NN cord-312840-jvdph782 122 10 of of IN cord-312840-jvdph782 122 11 disease disease NN cord-312840-jvdph782 122 12 appears appear VBZ cord-312840-jvdph782 122 13 to to TO cord-312840-jvdph782 122 14 be be VB cord-312840-jvdph782 122 15 greatest great JJS cord-312840-jvdph782 122 16 amongst amongst IN cord-312840-jvdph782 122 17 the the DT cord-312840-jvdph782 122 18 young young JJ cord-312840-jvdph782 122 19 [ [ -LRB- cord-312840-jvdph782 122 20 21 21 CD cord-312840-jvdph782 122 21 ] ] -RRB- cord-312840-jvdph782 122 22 , , , cord-312840-jvdph782 122 23 a a DT cord-312840-jvdph782 122 24 finding finding NN cord-312840-jvdph782 122 25 consistent consistent JJ cord-312840-jvdph782 122 26 with with IN cord-312840-jvdph782 122 27 other other JJ cord-312840-jvdph782 122 28 studies study NNS cord-312840-jvdph782 122 29 [ [ -LRB- cord-312840-jvdph782 122 30 1 1 CD cord-312840-jvdph782 122 31 , , , cord-312840-jvdph782 122 32 4 4 CD cord-312840-jvdph782 122 33 , , , cord-312840-jvdph782 122 34 7 7 CD cord-312840-jvdph782 122 35 ] ] -RRB- cord-312840-jvdph782 122 36 . . . cord-312840-jvdph782 123 1 These these DT cord-312840-jvdph782 123 2 data datum NNS cord-312840-jvdph782 123 3 argue argue VBP cord-312840-jvdph782 123 4 that that IN cord-312840-jvdph782 123 5 aiming aim VBG cord-312840-jvdph782 123 6 interventions intervention NNS cord-312840-jvdph782 123 7 at at IN cord-312840-jvdph782 123 8 youth youth NN cord-312840-jvdph782 123 9 would would MD cord-312840-jvdph782 123 10 target target VB cord-312840-jvdph782 123 11 the the DT cord-312840-jvdph782 123 12 group group NN cord-312840-jvdph782 123 13 that that WDT cord-312840-jvdph782 123 14 carries carry VBZ cord-312840-jvdph782 123 15 the the DT cord-312840-jvdph782 123 16 largest large JJS cord-312840-jvdph782 123 17 burden burden NN cord-312840-jvdph782 123 18 and and CC cord-312840-jvdph782 123 19 should should MD cord-312840-jvdph782 123 20 have have VB cord-312840-jvdph782 123 21 the the DT cord-312840-jvdph782 123 22 best good JJS cord-312840-jvdph782 123 23 chance chance NN cord-312840-jvdph782 123 24 of of IN cord-312840-jvdph782 123 25 success success NN cord-312840-jvdph782 123 26 in in IN cord-312840-jvdph782 123 27 limiting limit VBG cord-312840-jvdph782 123 28 transmission transmission NN cord-312840-jvdph782 123 29 . . . cord-312840-jvdph782 124 1 This this DT cord-312840-jvdph782 124 2 finding finding NN cord-312840-jvdph782 124 3 is be VBZ cord-312840-jvdph782 124 4 consistent consistent JJ cord-312840-jvdph782 124 5 with with IN cord-312840-jvdph782 124 6 the the DT cord-312840-jvdph782 124 7 strategy strategy NN cord-312840-jvdph782 124 8 proposed propose VBN cord-312840-jvdph782 124 9 by by IN cord-312840-jvdph782 124 10 Wallinga Wallinga NNP cord-312840-jvdph782 124 11 et et NNP cord-312840-jvdph782 124 12 al al NNP cord-312840-jvdph782 124 13 . . . cord-312840-jvdph782 125 1 [ [ -LRB- cord-312840-jvdph782 125 2 18 18 CD cord-312840-jvdph782 125 3 ] ] -RRB- cord-312840-jvdph782 125 4 and and CC cord-312840-jvdph782 125 5 provides provide VBZ cord-312840-jvdph782 125 6 further further JJ cord-312840-jvdph782 125 7 information information NN cord-312840-jvdph782 125 8 in in IN cord-312840-jvdph782 125 9 the the DT cord-312840-jvdph782 125 10 form form NN cord-312840-jvdph782 125 11 of of IN cord-312840-jvdph782 125 12 actual actual JJ cord-312840-jvdph782 125 13 estimates estimate NNS cord-312840-jvdph782 125 14 of of IN cord-312840-jvdph782 125 15 the the DT cord-312840-jvdph782 125 16 reproductive reproductive JJ cord-312840-jvdph782 125 17 number number NN cord-312840-jvdph782 125 18 . . . cord-312840-jvdph782 126 1 Our -PRON- PRP$ cord-312840-jvdph782 126 2 results result NNS cord-312840-jvdph782 126 3 also also RB cord-312840-jvdph782 126 4 illustrate illustrate VBP cord-312840-jvdph782 126 5 the the DT cord-312840-jvdph782 126 6 importance importance NN cord-312840-jvdph782 126 7 of of IN cord-312840-jvdph782 126 8 accounting account VBG cord-312840-jvdph782 126 9 for for IN cord-312840-jvdph782 126 10 the the DT cord-312840-jvdph782 126 11 age age NN cord-312840-jvdph782 126 12 structure structure NN cord-312840-jvdph782 126 13 when when WRB cord-312840-jvdph782 126 14 estimating estimate VBG cord-312840-jvdph782 126 15 reproduction reproduction NN cord-312840-jvdph782 126 16 numbers number NNS cord-312840-jvdph782 126 17 . . . cord-312840-jvdph782 127 1 Though though IN cord-312840-jvdph782 127 2 the the DT cord-312840-jvdph782 127 3 overall overall JJ cord-312840-jvdph782 127 4 estimates estimate NNS cord-312840-jvdph782 127 5 of of IN cord-312840-jvdph782 127 6 R r NN cord-312840-jvdph782 127 7 0 0 CD cord-312840-jvdph782 127 8 are be VBP cord-312840-jvdph782 127 9 unaffected unaffected JJ cord-312840-jvdph782 127 10 by by IN cord-312840-jvdph782 127 11 the the DT cord-312840-jvdph782 127 12 incorporation incorporation NN cord-312840-jvdph782 127 13 of of IN cord-312840-jvdph782 127 14 this this DT cord-312840-jvdph782 127 15 information information NN cord-312840-jvdph782 127 16 , , , cord-312840-jvdph782 127 17 we -PRON- PRP cord-312840-jvdph782 127 18 obtain obtain VBP cord-312840-jvdph782 127 19 much much RB cord-312840-jvdph782 127 20 richer rich JJR cord-312840-jvdph782 127 21 information information NN cord-312840-jvdph782 127 22 with with IN cord-312840-jvdph782 127 23 the the DT cord-312840-jvdph782 127 24 ability ability NN cord-312840-jvdph782 127 25 to to TO cord-312840-jvdph782 127 26 obtain obtain VB cord-312840-jvdph782 127 27 age age NN cord-312840-jvdph782 127 28 - - HYPH cord-312840-jvdph782 127 29 specific specific JJ cord-312840-jvdph782 127 30 estimates estimate NNS cord-312840-jvdph782 127 31 of of IN cord-312840-jvdph782 127 32 the the DT cord-312840-jvdph782 127 33 reproductive reproductive JJ cord-312840-jvdph782 127 34 number number NN cord-312840-jvdph782 127 35 . . . cord-312840-jvdph782 128 1 This this DT cord-312840-jvdph782 128 2 analysis analysis NN cord-312840-jvdph782 128 3 provides provide VBZ cord-312840-jvdph782 128 4 greater great JJR cord-312840-jvdph782 128 5 insight insight NN cord-312840-jvdph782 128 6 into into IN cord-312840-jvdph782 128 7 the the DT cord-312840-jvdph782 128 8 dynamics dynamic NNS cord-312840-jvdph782 128 9 of of IN cord-312840-jvdph782 128 10 disease disease NN cord-312840-jvdph782 128 11 transmission transmission NN cord-312840-jvdph782 128 12 and and CC cord-312840-jvdph782 128 13 informs inform VBZ cord-312840-jvdph782 128 14 intervention intervention NN cord-312840-jvdph782 128 15 strategies strategy NNS cord-312840-jvdph782 128 16 . . . cord-312840-jvdph782 129 1 The the DT cord-312840-jvdph782 129 2 results result NNS cord-312840-jvdph782 129 3 obtained obtain VBD cord-312840-jvdph782 129 4 using use VBG cord-312840-jvdph782 129 5 information information NN cord-312840-jvdph782 129 6 on on IN cord-312840-jvdph782 129 7 transmission transmission NN cord-312840-jvdph782 129 8 dynamics dynamic NNS cord-312840-jvdph782 129 9 from from IN cord-312840-jvdph782 129 10 the the DT cord-312840-jvdph782 129 11 study study NN cord-312840-jvdph782 129 12 based base VBN cord-312840-jvdph782 129 13 in in IN cord-312840-jvdph782 129 14 South South NNP cord-312840-jvdph782 129 15 Africa Africa NNP cord-312840-jvdph782 129 16 [ [ -LRB- cord-312840-jvdph782 129 17 12 12 CD cord-312840-jvdph782 129 18 ] ] -RRB- cord-312840-jvdph782 129 19 as as RB cord-312840-jvdph782 129 20 well well RB cord-312840-jvdph782 129 21 as as IN cord-312840-jvdph782 129 22 that that DT cord-312840-jvdph782 129 23 of of IN cord-312840-jvdph782 129 24 the the DT cord-312840-jvdph782 129 25 PolyMod PolyMod NNP cord-312840-jvdph782 129 26 study study NN cord-312840-jvdph782 129 27 [ [ -LRB- cord-312840-jvdph782 129 28 5 5 CD cord-312840-jvdph782 129 29 ] ] -RRB- cord-312840-jvdph782 129 30 , , , cord-312840-jvdph782 129 31 appear appear VBP cord-312840-jvdph782 129 32 to to TO cord-312840-jvdph782 129 33 corroborate corroborate VB cord-312840-jvdph782 129 34 previous previous JJ cord-312840-jvdph782 129 35 results result NNS cord-312840-jvdph782 129 36 for for IN cord-312840-jvdph782 129 37 influenza influenza NN cord-312840-jvdph782 129 38 pandemics pandemic NNS cord-312840-jvdph782 129 39 [ [ -LRB- cord-312840-jvdph782 129 40 2 2 CD cord-312840-jvdph782 129 41 , , , cord-312840-jvdph782 129 42 3 3 CD cord-312840-jvdph782 129 43 , , , cord-312840-jvdph782 129 44 19 19 CD cord-312840-jvdph782 129 45 ] ] -RRB- cord-312840-jvdph782 129 46 which which WDT cord-312840-jvdph782 129 47 seem seem VBP cord-312840-jvdph782 129 48 to to TO cord-312840-jvdph782 129 49 imply imply VB cord-312840-jvdph782 129 50 that that IN cord-312840-jvdph782 129 51 school school NN cord-312840-jvdph782 129 52 aged aged JJ cord-312840-jvdph782 129 53 children child NNS cord-312840-jvdph782 129 54 are be VBP cord-312840-jvdph782 129 55 responsible responsible JJ cord-312840-jvdph782 129 56 for for IN cord-312840-jvdph782 129 57 the the DT cord-312840-jvdph782 129 58 bulk bulk NN cord-312840-jvdph782 129 59 of of IN cord-312840-jvdph782 129 60 disease disease NN cord-312840-jvdph782 129 61 transmission transmission NN cord-312840-jvdph782 129 62 . . . cord-312840-jvdph782 130 1 Specifically specifically RB cord-312840-jvdph782 130 2 we -PRON- PRP cord-312840-jvdph782 130 3 estimate estimate VBP cord-312840-jvdph782 130 4 thatR thatR NNP cord-312840-jvdph782 130 5 0 0 NFP cord-312840-jvdph782 130 6 is be VBZ cord-312840-jvdph782 130 7 highest high JJS cord-312840-jvdph782 130 8 for for IN cord-312840-jvdph782 130 9 10 10 CD cord-312840-jvdph782 130 10 - - SYM cord-312840-jvdph782 130 11 14 14 CD cord-312840-jvdph782 130 12 year year NN cord-312840-jvdph782 130 13 olds old NNS cord-312840-jvdph782 130 14 when when WRB cord-312840-jvdph782 130 15 using use VBG cord-312840-jvdph782 130 16 South south JJ cord-312840-jvdph782 130 17 African african JJ cord-312840-jvdph782 130 18 contact contact NN cord-312840-jvdph782 130 19 trace trace NN cord-312840-jvdph782 130 20 matrices matrix NNS cord-312840-jvdph782 130 21 ( ( -LRB- cord-312840-jvdph782 130 22 close close JJ cord-312840-jvdph782 130 23 contacts contact NNS cord-312840-jvdph782 130 24 : : : cord-312840-jvdph782 130 25 R r NN cord-312840-jvdph782 130 26 0 0 CD cord-312840-jvdph782 130 27 = = SYM cord-312840-jvdph782 130 28 1.53 1.53 CD cord-312840-jvdph782 130 29 , , , cord-312840-jvdph782 130 30 range range NN cord-312840-jvdph782 130 31 , , , cord-312840-jvdph782 130 32 1.49 1.49 CD cord-312840-jvdph782 130 33 - - SYM cord-312840-jvdph782 130 34 1.58 1.58 CD cord-312840-jvdph782 130 35 ; ; , cord-312840-jvdph782 130 36 physical physical JJ cord-312840-jvdph782 130 37 touch touch NN cord-312840-jvdph782 130 38 contacts contact NNS cord-312840-jvdph782 130 39 : : : cord-312840-jvdph782 130 40 R r NN cord-312840-jvdph782 130 41 0 0 CD cord-312840-jvdph782 130 42 = = SYM cord-312840-jvdph782 130 43 1.47 1.47 CD cord-312840-jvdph782 130 44 , , , cord-312840-jvdph782 130 45 range range NN cord-312840-jvdph782 130 46 , , , cord-312840-jvdph782 130 47 1.44 1.44 CD cord-312840-jvdph782 130 48 - - SYM cord-312840-jvdph782 130 49 1.51 1.51 CD cord-312840-jvdph782 130 50 ) ) -RRB- cord-312840-jvdph782 130 51 . . . cord-312840-jvdph782 131 1 These these DT cord-312840-jvdph782 131 2 results result NNS cord-312840-jvdph782 131 3 are be VBP cord-312840-jvdph782 131 4 similar similar JJ cord-312840-jvdph782 131 5 to to IN cord-312840-jvdph782 131 6 the the DT cord-312840-jvdph782 131 7 results result NNS cord-312840-jvdph782 131 8 from from IN cord-312840-jvdph782 131 9 other other JJ cord-312840-jvdph782 131 10 studies study NNS cord-312840-jvdph782 131 11 [ [ -LRB- cord-312840-jvdph782 131 12 2 2 CD cord-312840-jvdph782 131 13 , , , cord-312840-jvdph782 131 14 19 19 CD cord-312840-jvdph782 131 15 ] ] -RRB- cord-312840-jvdph782 131 16 and and CC cord-312840-jvdph782 131 17 those those DT cord-312840-jvdph782 131 18 obtained obtain VBN cord-312840-jvdph782 131 19 using use VBG cord-312840-jvdph782 131 20 the the DT cord-312840-jvdph782 131 21 European European NNP cord-312840-jvdph782 131 22 based base VBN cord-312840-jvdph782 131 23 contact contact NN cord-312840-jvdph782 131 24 matrices matrix NNS cord-312840-jvdph782 131 25 . . . cord-312840-jvdph782 132 1 Interestingly interestingly RB cord-312840-jvdph782 132 2 , , , cord-312840-jvdph782 132 3 it -PRON- PRP cord-312840-jvdph782 132 4 does do VBZ cord-312840-jvdph782 132 5 not not RB cord-312840-jvdph782 132 6 appear appear VB cord-312840-jvdph782 132 7 to to TO cord-312840-jvdph782 132 8 make make VB cord-312840-jvdph782 132 9 a a DT cord-312840-jvdph782 132 10 substantial substantial JJ cord-312840-jvdph782 132 11 difference difference NN cord-312840-jvdph782 132 12 which which WDT cord-312840-jvdph782 132 13 contact contact NN cord-312840-jvdph782 132 14 pattern pattern NN cord-312840-jvdph782 132 15 matrix matrix NN cord-312840-jvdph782 132 16 we -PRON- PRP cord-312840-jvdph782 132 17 use use VBP cord-312840-jvdph782 132 18 in in IN cord-312840-jvdph782 132 19 our -PRON- PRP$ cord-312840-jvdph782 132 20 analysis analysis NN cord-312840-jvdph782 132 21 . . . cord-312840-jvdph782 133 1 One one PRP cord-312840-jvdph782 133 2 would would MD cord-312840-jvdph782 133 3 assume assume VB cord-312840-jvdph782 133 4 that that IN cord-312840-jvdph782 133 5 the the DT cord-312840-jvdph782 133 6 matrices matrix NNS cord-312840-jvdph782 133 7 obtained obtain VBN cord-312840-jvdph782 133 8 in in IN cord-312840-jvdph782 133 9 South South NNP cord-312840-jvdph782 133 10 Africa Africa NNP cord-312840-jvdph782 133 11 would would MD cord-312840-jvdph782 133 12 be be VB cord-312840-jvdph782 133 13 most most RBS cord-312840-jvdph782 133 14 relevant relevant JJ cord-312840-jvdph782 133 15 to to IN cord-312840-jvdph782 133 16 the the DT cord-312840-jvdph782 133 17 outbreak outbreak NN cord-312840-jvdph782 133 18 data datum NNS cord-312840-jvdph782 133 19 we -PRON- PRP cord-312840-jvdph782 133 20 are be VBP cord-312840-jvdph782 133 21 analyzing analyze VBG cord-312840-jvdph782 133 22 and and CC cord-312840-jvdph782 133 23 indeed indeed RB cord-312840-jvdph782 133 24 , , , cord-312840-jvdph782 133 25 we -PRON- PRP cord-312840-jvdph782 133 26 have have VBP cord-312840-jvdph782 133 27 chosen choose VBN cord-312840-jvdph782 133 28 to to TO cord-312840-jvdph782 133 29 present present VB cord-312840-jvdph782 133 30 the the DT cord-312840-jvdph782 133 31 majority majority NN cord-312840-jvdph782 133 32 of of IN cord-312840-jvdph782 133 33 our -PRON- PRP$ cord-312840-jvdph782 133 34 results result NNS cord-312840-jvdph782 133 35 using use VBG cord-312840-jvdph782 133 36 these these DT cord-312840-jvdph782 133 37 matrices matrix NNS cord-312840-jvdph782 133 38 . . . cord-312840-jvdph782 134 1 We -PRON- PRP cord-312840-jvdph782 134 2 note note VBP cord-312840-jvdph782 134 3 , , , cord-312840-jvdph782 134 4 however however RB cord-312840-jvdph782 134 5 , , , cord-312840-jvdph782 134 6 that that IN cord-312840-jvdph782 134 7 when when WRB cord-312840-jvdph782 134 8 we -PRON- PRP cord-312840-jvdph782 134 9 use use VBP cord-312840-jvdph782 134 10 contact contact NN cord-312840-jvdph782 134 11 patterns pattern NNS cord-312840-jvdph782 134 12 from from IN cord-312840-jvdph782 134 13 other other JJ cord-312840-jvdph782 134 14 European european JJ cord-312840-jvdph782 134 15 countries country NNS cord-312840-jvdph782 134 16 , , , cord-312840-jvdph782 134 17 where where WRB cord-312840-jvdph782 134 18 the the DT cord-312840-jvdph782 134 19 demographics demographic NNS cord-312840-jvdph782 134 20 , , , cord-312840-jvdph782 134 21 climate climate NN cord-312840-jvdph782 134 22 , , , cord-312840-jvdph782 134 23 healthcare healthcare NN cord-312840-jvdph782 134 24 system system NN cord-312840-jvdph782 134 25 , , , cord-312840-jvdph782 134 26 government government NN cord-312840-jvdph782 134 27 , , , cord-312840-jvdph782 134 28 overall overall JJ cord-312840-jvdph782 134 29 health health NN cord-312840-jvdph782 134 30 , , , cord-312840-jvdph782 134 31 etc etc FW cord-312840-jvdph782 134 32 . . . cord-312840-jvdph782 134 33 are be VBP cord-312840-jvdph782 134 34 different different JJ cord-312840-jvdph782 134 35 from from IN cord-312840-jvdph782 134 36 that that DT cord-312840-jvdph782 134 37 of of IN cord-312840-jvdph782 134 38 South South NNP cord-312840-jvdph782 134 39 Africa Africa NNP cord-312840-jvdph782 134 40 , , , cord-312840-jvdph782 134 41 there there EX cord-312840-jvdph782 134 42 are be VBP cord-312840-jvdph782 134 43 only only RB cord-312840-jvdph782 134 44 minor minor JJ cord-312840-jvdph782 134 45 changes change NNS cord-312840-jvdph782 134 46 in in IN cord-312840-jvdph782 134 47 the the DT cord-312840-jvdph782 134 48 results result NNS cord-312840-jvdph782 134 49 . . . cord-312840-jvdph782 135 1 Indeed indeed RB cord-312840-jvdph782 135 2 , , , cord-312840-jvdph782 135 3 the the DT cord-312840-jvdph782 135 4 contact contact NN cord-312840-jvdph782 135 5 patterns pattern NNS cord-312840-jvdph782 135 6 observed observe VBN cord-312840-jvdph782 135 7 in in IN cord-312840-jvdph782 135 8 the the DT cord-312840-jvdph782 135 9 Polymod Polymod NNP cord-312840-jvdph782 135 10 study study NN cord-312840-jvdph782 135 11 and and CC cord-312840-jvdph782 135 12 the the DT cord-312840-jvdph782 135 13 South south JJ cord-312840-jvdph782 135 14 African african JJ cord-312840-jvdph782 135 15 contact contact NN cord-312840-jvdph782 135 16 study study NN cord-312840-jvdph782 135 17 are be VBP cord-312840-jvdph782 135 18 not not RB cord-312840-jvdph782 135 19 substantially substantially RB cord-312840-jvdph782 135 20 different different JJ cord-312840-jvdph782 135 21 , , , cord-312840-jvdph782 135 22 however however RB cord-312840-jvdph782 135 23 they -PRON- PRP cord-312840-jvdph782 135 24 are be VBP cord-312840-jvdph782 135 25 not not RB cord-312840-jvdph782 135 26 identical identical JJ cord-312840-jvdph782 135 27 . . . cord-312840-jvdph782 136 1 This this DT cord-312840-jvdph782 136 2 appears appear VBZ cord-312840-jvdph782 136 3 to to TO cord-312840-jvdph782 136 4 argue argue VB cord-312840-jvdph782 136 5 that that IN cord-312840-jvdph782 136 6 using use VBG cord-312840-jvdph782 136 7 some some DT cord-312840-jvdph782 136 8 form form NN cord-312840-jvdph782 136 9 of of IN cord-312840-jvdph782 136 10 adjustment adjustment NN cord-312840-jvdph782 136 11 is be VBZ cord-312840-jvdph782 136 12 superior superior JJ cord-312840-jvdph782 136 13 to to IN cord-312840-jvdph782 136 14 assuming assume VBG cord-312840-jvdph782 136 15 homogenous homogenous JJ cord-312840-jvdph782 136 16 mixing mixing NN cord-312840-jvdph782 136 17 , , , cord-312840-jvdph782 136 18 but but CC cord-312840-jvdph782 136 19 the the DT cord-312840-jvdph782 136 20 method method NN cord-312840-jvdph782 136 21 we -PRON- PRP cord-312840-jvdph782 136 22 propose propose VBP cord-312840-jvdph782 136 23 is be VBZ cord-312840-jvdph782 136 24 not not RB cord-312840-jvdph782 136 25 overly overly RB cord-312840-jvdph782 136 26 sensitive sensitive JJ cord-312840-jvdph782 136 27 to to IN cord-312840-jvdph782 136 28 the the DT cord-312840-jvdph782 136 29 form form NN cord-312840-jvdph782 136 30 the the DT cord-312840-jvdph782 136 31 adjustments adjustment NNS cord-312840-jvdph782 136 32 take take VBP cord-312840-jvdph782 136 33 [ [ -LRB- cord-312840-jvdph782 136 34 24 24 CD cord-312840-jvdph782 136 35 ] ] -RRB- cord-312840-jvdph782 136 36 . . . cord-312840-jvdph782 137 1 This this DT cord-312840-jvdph782 137 2 result result NN cord-312840-jvdph782 137 3 is be VBZ cord-312840-jvdph782 137 4 similar similar JJ cord-312840-jvdph782 137 5 to to IN cord-312840-jvdph782 137 6 that that DT cord-312840-jvdph782 137 7 of of IN cord-312840-jvdph782 137 8 Glass Glass NNP cord-312840-jvdph782 137 9 et et NNP cord-312840-jvdph782 137 10 al al NNP cord-312840-jvdph782 137 11 . . . cord-312840-jvdph782 138 1 [ [ -LRB- cord-312840-jvdph782 138 2 2 2 LS cord-312840-jvdph782 138 3 ] ] -RRB- cord-312840-jvdph782 138 4 who who WP cord-312840-jvdph782 138 5 experimented experiment VBD cord-312840-jvdph782 138 6 with with IN cord-312840-jvdph782 138 7 four four CD cord-312840-jvdph782 138 8 forms form NNS cord-312840-jvdph782 138 9 of of IN cord-312840-jvdph782 138 10 next next JJ cord-312840-jvdph782 138 11 generation generation NN cord-312840-jvdph782 138 12 matrices matrix NNS cord-312840-jvdph782 138 13 to to TO cord-312840-jvdph782 138 14 estimate estimate VB cord-312840-jvdph782 138 15 the the DT cord-312840-jvdph782 138 16 reproductive reproductive JJ cord-312840-jvdph782 138 17 number number NN cord-312840-jvdph782 138 18 for for IN cord-312840-jvdph782 138 19 adults adult NNS cord-312840-jvdph782 138 20 and and CC cord-312840-jvdph782 138 21 children child NNS cord-312840-jvdph782 138 22 separately separately RB cord-312840-jvdph782 138 23 . . . cord-312840-jvdph782 139 1 They -PRON- PRP cord-312840-jvdph782 139 2 found find VBD cord-312840-jvdph782 139 3 that that IN cord-312840-jvdph782 139 4 the the DT cord-312840-jvdph782 139 5 estimates estimate NNS cord-312840-jvdph782 139 6 of of IN cord-312840-jvdph782 139 7 the the DT cord-312840-jvdph782 139 8 reproductive reproductive JJ cord-312840-jvdph782 139 9 numbers number NNS cord-312840-jvdph782 139 10 were be VBD cord-312840-jvdph782 139 11 not not RB cord-312840-jvdph782 139 12 overly overly RB cord-312840-jvdph782 139 13 sensitive sensitive JJ cord-312840-jvdph782 139 14 to to IN cord-312840-jvdph782 139 15 the the DT cord-312840-jvdph782 139 16 matrix matrix NN cord-312840-jvdph782 139 17 forms form NNS cord-312840-jvdph782 139 18 that that WDT cord-312840-jvdph782 139 19 they -PRON- PRP cord-312840-jvdph782 139 20 assumed assume VBD cord-312840-jvdph782 139 21 . . . cord-312840-jvdph782 140 1 However however RB cord-312840-jvdph782 140 2 , , , cord-312840-jvdph782 140 3 one one PRP cord-312840-jvdph782 140 4 should should MD cord-312840-jvdph782 140 5 still still RB cord-312840-jvdph782 140 6 take take VB cord-312840-jvdph782 140 7 care care NN cord-312840-jvdph782 140 8 in in IN cord-312840-jvdph782 140 9 the the DT cord-312840-jvdph782 140 10 assumptions assumption NNS cord-312840-jvdph782 140 11 used use VBN cord-312840-jvdph782 140 12 when when WRB cord-312840-jvdph782 140 13 implementing implement VBG cord-312840-jvdph782 140 14 this this DT cord-312840-jvdph782 140 15 method method NN cord-312840-jvdph782 140 16 , , , cord-312840-jvdph782 140 17 or or CC cord-312840-jvdph782 140 18 others other NNS cord-312840-jvdph782 140 19 like like IN cord-312840-jvdph782 140 20 it -PRON- PRP cord-312840-jvdph782 140 21 . . . cord-312840-jvdph782 141 1 Our -PRON- PRP$ cord-312840-jvdph782 141 2 study study NN cord-312840-jvdph782 141 3 is be VBZ cord-312840-jvdph782 141 4 only only RB cord-312840-jvdph782 141 5 one one CD cord-312840-jvdph782 141 6 instance instance NN cord-312840-jvdph782 141 7 and and CC cord-312840-jvdph782 141 8 it -PRON- PRP cord-312840-jvdph782 141 9 is be VBZ cord-312840-jvdph782 141 10 not not RB cord-312840-jvdph782 141 11 clear clear JJ cord-312840-jvdph782 141 12 that that IN cord-312840-jvdph782 141 13 the the DT cord-312840-jvdph782 141 14 results result NNS cord-312840-jvdph782 141 15 we -PRON- PRP cord-312840-jvdph782 141 16 obtain obtain VBP cord-312840-jvdph782 141 17 would would MD cord-312840-jvdph782 141 18 replicate replicate VB cord-312840-jvdph782 141 19 in in IN cord-312840-jvdph782 141 20 other other JJ cord-312840-jvdph782 141 21 settings setting NNS cord-312840-jvdph782 141 22 . . . cord-312840-jvdph782 142 1 For for IN cord-312840-jvdph782 142 2 instance instance NN cord-312840-jvdph782 142 3 , , , cord-312840-jvdph782 142 4 if if IN cord-312840-jvdph782 142 5 one one CD cord-312840-jvdph782 142 6 were be VBD cord-312840-jvdph782 142 7 to to TO cord-312840-jvdph782 142 8 always always RB cord-312840-jvdph782 142 9 use use VB cord-312840-jvdph782 142 10 the the DT cord-312840-jvdph782 142 11 Polymod Polymod NNP cord-312840-jvdph782 142 12 study study NN cord-312840-jvdph782 142 13 information information NN cord-312840-jvdph782 142 14 for for IN cord-312840-jvdph782 142 15 studies study NNS cord-312840-jvdph782 142 16 throughout throughout IN cord-312840-jvdph782 142 17 the the DT cord-312840-jvdph782 142 18 world world NN cord-312840-jvdph782 142 19 , , , cord-312840-jvdph782 142 20 there there EX cord-312840-jvdph782 142 21 is be VBZ cord-312840-jvdph782 142 22 still still RB cord-312840-jvdph782 142 23 the the DT cord-312840-jvdph782 142 24 potential potential NN cord-312840-jvdph782 142 25 for for IN cord-312840-jvdph782 142 26 errors error NNS cord-312840-jvdph782 142 27 if if IN cord-312840-jvdph782 142 28 contact contact NN cord-312840-jvdph782 142 29 patterns pattern NNS cord-312840-jvdph782 142 30 do do VBP cord-312840-jvdph782 142 31 differ differ VB cord-312840-jvdph782 142 32 dramatically dramatically RB cord-312840-jvdph782 142 33 from from IN cord-312840-jvdph782 142 34 those those DT cord-312840-jvdph782 142 35 observed observe VBN cord-312840-jvdph782 142 36 in in IN cord-312840-jvdph782 142 37 Europe Europe NNP cord-312840-jvdph782 142 38 . . . cord-312840-jvdph782 143 1 While while IN cord-312840-jvdph782 143 2 it -PRON- PRP cord-312840-jvdph782 143 3 is be VBZ cord-312840-jvdph782 143 4 impossible impossible JJ cord-312840-jvdph782 143 5 to to TO cord-312840-jvdph782 143 6 know know VB cord-312840-jvdph782 143 7 with with IN cord-312840-jvdph782 143 8 certainty certainty NN cord-312840-jvdph782 143 9 if if IN cord-312840-jvdph782 143 10 this this DT cord-312840-jvdph782 143 11 is be VBZ cord-312840-jvdph782 143 12 the the DT cord-312840-jvdph782 143 13 case case NN cord-312840-jvdph782 143 14 without without IN cord-312840-jvdph782 143 15 detailed detailed JJ cord-312840-jvdph782 143 16 contact contact NN cord-312840-jvdph782 143 17 pattern pattern NN cord-312840-jvdph782 143 18 information information NN cord-312840-jvdph782 143 19 for for IN cord-312840-jvdph782 143 20 the the DT cord-312840-jvdph782 143 21 area area NN cord-312840-jvdph782 143 22 of of IN cord-312840-jvdph782 143 23 study study NN cord-312840-jvdph782 143 24 , , , cord-312840-jvdph782 143 25 one one PRP cord-312840-jvdph782 143 26 can can MD cord-312840-jvdph782 143 27 , , , cord-312840-jvdph782 143 28 at at IN cord-312840-jvdph782 143 29 the the DT cord-312840-jvdph782 143 30 least least JJS cord-312840-jvdph782 143 31 conduct conduct VB cord-312840-jvdph782 143 32 a a DT cord-312840-jvdph782 143 33 sensitivity sensitivity NN cord-312840-jvdph782 143 34 analysis analysis NN cord-312840-jvdph782 143 35 to to TO cord-312840-jvdph782 143 36 determine determine VB cord-312840-jvdph782 143 37 the the DT cord-312840-jvdph782 143 38 potential potential JJ cord-312840-jvdph782 143 39 impact impact NN cord-312840-jvdph782 143 40 of of IN cord-312840-jvdph782 143 41 the the DT cord-312840-jvdph782 143 42 contact contact NN cord-312840-jvdph782 143 43 matrix matrix NN cord-312840-jvdph782 143 44 on on IN cord-312840-jvdph782 143 45 the the DT cord-312840-jvdph782 143 46 analysis analysis NN cord-312840-jvdph782 143 47 . . . cord-312840-jvdph782 144 1 Additionally additionally RB cord-312840-jvdph782 144 2 we -PRON- PRP cord-312840-jvdph782 144 3 implicitly implicitly RB cord-312840-jvdph782 144 4 assume assume VBP cord-312840-jvdph782 144 5 that that IN cord-312840-jvdph782 144 6 contact contact NN cord-312840-jvdph782 144 7 patterns pattern NNS cord-312840-jvdph782 144 8 are be VBP cord-312840-jvdph782 144 9 directly directly RB cord-312840-jvdph782 144 10 related relate VBN cord-312840-jvdph782 144 11 to to IN cord-312840-jvdph782 144 12 transmission transmission NN cord-312840-jvdph782 144 13 probabilities probability NNS cord-312840-jvdph782 144 14 , , , cord-312840-jvdph782 144 15 an an DT cord-312840-jvdph782 144 16 assumption assumption NN cord-312840-jvdph782 144 17 that that WDT cord-312840-jvdph782 144 18 has have VBZ cord-312840-jvdph782 144 19 yet yet RB cord-312840-jvdph782 144 20 to to TO cord-312840-jvdph782 144 21 be be VB cord-312840-jvdph782 144 22 rigorously rigorously RB cord-312840-jvdph782 144 23 tested test VBN cord-312840-jvdph782 144 24 . . . cord-312840-jvdph782 145 1 There there EX cord-312840-jvdph782 145 2 is be VBZ cord-312840-jvdph782 145 3 also also RB cord-312840-jvdph782 145 4 work work NN cord-312840-jvdph782 145 5 to to TO cord-312840-jvdph782 145 6 show show VB cord-312840-jvdph782 145 7 that that IN cord-312840-jvdph782 145 8 contact contact NN cord-312840-jvdph782 145 9 patterns pattern NNS cord-312840-jvdph782 145 10 can can MD cord-312840-jvdph782 145 11 change change VB cord-312840-jvdph782 145 12 considerably considerably RB cord-312840-jvdph782 145 13 during during IN cord-312840-jvdph782 145 14 illness illness NN cord-312840-jvdph782 145 15 [ [ -LRB- cord-312840-jvdph782 145 16 25 25 CD cord-312840-jvdph782 145 17 , , , cord-312840-jvdph782 145 18 26 26 CD cord-312840-jvdph782 145 19 ] ] -RRB- cord-312840-jvdph782 145 20 . . . cord-312840-jvdph782 146 1 Our -PRON- PRP$ cord-312840-jvdph782 146 2 work work NN cord-312840-jvdph782 146 3 relies rely VBZ cord-312840-jvdph782 146 4 on on IN cord-312840-jvdph782 146 5 the the DT cord-312840-jvdph782 146 6 contact contact NN cord-312840-jvdph782 146 7 patterns pattern NNS cord-312840-jvdph782 146 8 of of IN cord-312840-jvdph782 146 9 healthy healthy JJ cord-312840-jvdph782 146 10 individuals individual NNS cord-312840-jvdph782 146 11 . . . cord-312840-jvdph782 147 1 While while IN cord-312840-jvdph782 147 2 we -PRON- PRP cord-312840-jvdph782 147 3 suspect suspect VBP cord-312840-jvdph782 147 4 , , , cord-312840-jvdph782 147 5 based base VBN cord-312840-jvdph782 147 6 on on IN cord-312840-jvdph782 147 7 our -PRON- PRP$ cord-312840-jvdph782 147 8 sensitivity sensitivity NN cord-312840-jvdph782 147 9 analyses analysis NNS cord-312840-jvdph782 147 10 , , , cord-312840-jvdph782 147 11 that that IN cord-312840-jvdph782 147 12 this this DT cord-312840-jvdph782 147 13 will will MD cord-312840-jvdph782 147 14 not not RB cord-312840-jvdph782 147 15 have have VB cord-312840-jvdph782 147 16 a a DT cord-312840-jvdph782 147 17 substantial substantial JJ cord-312840-jvdph782 147 18 impact impact NN cord-312840-jvdph782 147 19 on on IN cord-312840-jvdph782 147 20 our -PRON- PRP$ cord-312840-jvdph782 147 21 results result NNS cord-312840-jvdph782 147 22 , , , cord-312840-jvdph782 147 23 this this DT cord-312840-jvdph782 147 24 is be VBZ cord-312840-jvdph782 147 25 important important JJ cord-312840-jvdph782 147 26 to to TO cord-312840-jvdph782 147 27 note note VB cord-312840-jvdph782 147 28 . . . cord-312840-jvdph782 148 1 It -PRON- PRP cord-312840-jvdph782 148 2 is be VBZ cord-312840-jvdph782 148 3 important important JJ cord-312840-jvdph782 148 4 to to TO cord-312840-jvdph782 148 5 note note VB cord-312840-jvdph782 148 6 the the DT cord-312840-jvdph782 148 7 caveats caveat NNS cord-312840-jvdph782 148 8 and and CC cord-312840-jvdph782 148 9 limitations limitation NNS cord-312840-jvdph782 148 10 of of IN cord-312840-jvdph782 148 11 this this DT cord-312840-jvdph782 148 12 study study NN cord-312840-jvdph782 148 13 . . . cord-312840-jvdph782 149 1 Our -PRON- PRP$ cord-312840-jvdph782 149 2 results result NNS cord-312840-jvdph782 149 3 would would MD cord-312840-jvdph782 149 4 be be VB cord-312840-jvdph782 149 5 impacted impact VBN cord-312840-jvdph782 149 6 if if IN cord-312840-jvdph782 149 7 reporting reporting NN cord-312840-jvdph782 149 8 was be VBD cord-312840-jvdph782 149 9 inconsistent inconsistent JJ cord-312840-jvdph782 149 10 throughout throughout IN cord-312840-jvdph782 149 11 the the DT cord-312840-jvdph782 149 12 outbreak outbreak NN cord-312840-jvdph782 149 13 among among IN cord-312840-jvdph782 149 14 the the DT cord-312840-jvdph782 149 15 age age NN cord-312840-jvdph782 149 16 groups group NNS cord-312840-jvdph782 149 17 . . . cord-312840-jvdph782 150 1 For for IN cord-312840-jvdph782 150 2 instance instance NN cord-312840-jvdph782 150 3 if if IN cord-312840-jvdph782 150 4 reporting reporting NN cord-312840-jvdph782 150 5 was be VBD cord-312840-jvdph782 150 6 very very RB cord-312840-jvdph782 150 7 good good JJ cord-312840-jvdph782 150 8 among among IN cord-312840-jvdph782 150 9 one one CD cord-312840-jvdph782 150 10 age age NN cord-312840-jvdph782 150 11 group group NN cord-312840-jvdph782 150 12 initially initially RB cord-312840-jvdph782 150 13 but but CC cord-312840-jvdph782 150 14 declined decline VBD cord-312840-jvdph782 150 15 in in IN cord-312840-jvdph782 150 16 quality quality NN cord-312840-jvdph782 150 17 as as IN cord-312840-jvdph782 150 18 the the DT cord-312840-jvdph782 150 19 outbreak outbreak NN cord-312840-jvdph782 150 20 progressed progress VBD cord-312840-jvdph782 150 21 , , , cord-312840-jvdph782 150 22 we -PRON- PRP cord-312840-jvdph782 150 23 can can MD cord-312840-jvdph782 150 24 expect expect VB cord-312840-jvdph782 150 25 that that IN cord-312840-jvdph782 150 26 our -PRON- PRP$ cord-312840-jvdph782 150 27 results result NNS cord-312840-jvdph782 150 28 would would MD cord-312840-jvdph782 150 29 be be VB cord-312840-jvdph782 150 30 biased bias VBN cord-312840-jvdph782 150 31 [ [ -LRB- cord-312840-jvdph782 150 32 27 27 CD cord-312840-jvdph782 150 33 ] ] -RRB- cord-312840-jvdph782 150 34 . . . cord-312840-jvdph782 151 1 In in IN cord-312840-jvdph782 151 2 general general JJ cord-312840-jvdph782 151 3 the the DT cord-312840-jvdph782 151 4 default default NN cord-312840-jvdph782 151 5 assumption assumption NN cord-312840-jvdph782 151 6 is be VBZ cord-312840-jvdph782 151 7 that that IN cord-312840-jvdph782 151 8 the the DT cord-312840-jvdph782 151 9 pyramid pyramid NN cord-312840-jvdph782 151 10 of of IN cord-312840-jvdph782 151 11 disease disease NNP cord-312840-jvdph782 151 12 reporting reporting NN cord-312840-jvdph782 151 13 described describe VBN cord-312840-jvdph782 151 14 in in IN cord-312840-jvdph782 151 15 [ [ -LRB- cord-312840-jvdph782 151 16 28 28 CD cord-312840-jvdph782 151 17 , , , cord-312840-jvdph782 151 18 29 29 CD cord-312840-jvdph782 151 19 ] ] -RRB- cord-312840-jvdph782 151 20 is be VBZ cord-312840-jvdph782 151 21 the the DT cord-312840-jvdph782 151 22 same same JJ cord-312840-jvdph782 151 23 for for IN cord-312840-jvdph782 151 24 all all DT cord-312840-jvdph782 151 25 age age NN cord-312840-jvdph782 151 26 groups group NNS cord-312840-jvdph782 151 27 . . . cord-312840-jvdph782 152 1 Our -PRON- PRP$ cord-312840-jvdph782 152 2 second second JJ cord-312840-jvdph782 152 3 sensitivity sensitivity NN cord-312840-jvdph782 152 4 analysis analysis NN cord-312840-jvdph782 152 5 ( ( -LRB- cord-312840-jvdph782 152 6 Appendix Appendix NNP cord-312840-jvdph782 152 7 3 3 CD cord-312840-jvdph782 152 8 ) ) -RRB- cord-312840-jvdph782 152 9 explores explore VBZ cord-312840-jvdph782 152 10 the the DT cord-312840-jvdph782 152 11 impact impact NN cord-312840-jvdph782 152 12 of of IN cord-312840-jvdph782 152 13 this this DT cord-312840-jvdph782 152 14 assumption assumption NN cord-312840-jvdph782 152 15 and and CC cord-312840-jvdph782 152 16 shows show VBZ cord-312840-jvdph782 152 17 that that IN cord-312840-jvdph782 152 18 if if IN cord-312840-jvdph782 152 19 reporting report VBG cord-312840-jvdph782 152 20 or or CC cord-312840-jvdph782 152 21 healthcare healthcare NN cord-312840-jvdph782 152 22 seeking seek VBG cord-312840-jvdph782 152 23 behavior behavior NN cord-312840-jvdph782 152 24 is be VBZ cord-312840-jvdph782 152 25 much much RB cord-312840-jvdph782 152 26 lower low JJR cord-312840-jvdph782 152 27 among among IN cord-312840-jvdph782 152 28 middle middle JJ cord-312840-jvdph782 152 29 aged aged JJ cord-312840-jvdph782 152 30 groups group NNS cord-312840-jvdph782 152 31 than than IN cord-312840-jvdph782 152 32 the the DT cord-312840-jvdph782 152 33 very very RB cord-312840-jvdph782 152 34 old old JJ cord-312840-jvdph782 152 35 and and CC cord-312840-jvdph782 152 36 very very RB cord-312840-jvdph782 152 37 young young JJ cord-312840-jvdph782 152 38 , , , cord-312840-jvdph782 152 39 our -PRON- PRP$ cord-312840-jvdph782 152 40 results result NNS cord-312840-jvdph782 152 41 will will MD cord-312840-jvdph782 152 42 change change VB cord-312840-jvdph782 152 43 dramatically dramatically RB cord-312840-jvdph782 152 44 . . . cord-312840-jvdph782 153 1 In in IN cord-312840-jvdph782 153 2 the the DT cord-312840-jvdph782 153 3 extreme extreme JJ cord-312840-jvdph782 153 4 case case NN cord-312840-jvdph782 153 5 , , , cord-312840-jvdph782 153 6 we -PRON- PRP cord-312840-jvdph782 153 7 see see VBP cord-312840-jvdph782 153 8 that that IN cord-312840-jvdph782 153 9 transmission transmission NN cord-312840-jvdph782 153 10 is be VBZ cord-312840-jvdph782 153 11 mostly mostly RB cord-312840-jvdph782 153 12 attributable attributable JJ cord-312840-jvdph782 153 13 to to IN cord-312840-jvdph782 153 14 those those DT cord-312840-jvdph782 153 15 who who WP cord-312840-jvdph782 153 16 are be VBP cord-312840-jvdph782 153 17 at at RB cord-312840-jvdph782 153 18 least least RBS cord-312840-jvdph782 153 19 30 30 CD cord-312840-jvdph782 153 20 years year NNS cord-312840-jvdph782 153 21 old old JJ cord-312840-jvdph782 153 22 and and CC cord-312840-jvdph782 153 23 that that IN cord-312840-jvdph782 153 24 the the DT cord-312840-jvdph782 153 25 very very RB cord-312840-jvdph782 153 26 young young JJ cord-312840-jvdph782 153 27 are be VBP cord-312840-jvdph782 153 28 unable unable JJ cord-312840-jvdph782 153 29 to to TO cord-312840-jvdph782 153 30 sustain sustain VB cord-312840-jvdph782 153 31 transmission transmission NN cord-312840-jvdph782 153 32 . . . cord-312840-jvdph782 154 1 While while IN cord-312840-jvdph782 154 2 this this DT cord-312840-jvdph782 154 3 result result NN cord-312840-jvdph782 154 4 is be VBZ cord-312840-jvdph782 154 5 contrary contrary JJ cord-312840-jvdph782 154 6 to to IN cord-312840-jvdph782 154 7 what what WP cord-312840-jvdph782 154 8 has have VBZ cord-312840-jvdph782 154 9 been be VBN cord-312840-jvdph782 154 10 reported report VBN cord-312840-jvdph782 154 11 in in IN cord-312840-jvdph782 154 12 the the DT cord-312840-jvdph782 154 13 scientific scientific JJ cord-312840-jvdph782 154 14 literature literature NN cord-312840-jvdph782 154 15 to to IN cord-312840-jvdph782 154 16 date date NN cord-312840-jvdph782 154 17 , , , cord-312840-jvdph782 154 18 the the DT cord-312840-jvdph782 154 19 potential potential NN cord-312840-jvdph782 154 20 for for IN cord-312840-jvdph782 154 21 reporting report VBG cord-312840-jvdph782 154 22 inconsistencies inconsistency NNS cord-312840-jvdph782 154 23 that that IN cord-312840-jvdph782 154 24 we -PRON- PRP cord-312840-jvdph782 154 25 explore explore VBP cord-312840-jvdph782 154 26 are be VBP cord-312840-jvdph782 154 27 not not RB cord-312840-jvdph782 154 28 unlikely unlikely JJ cord-312840-jvdph782 154 29 , , , cord-312840-jvdph782 154 30 and and CC cord-312840-jvdph782 154 31 have have VBP cord-312840-jvdph782 154 32 not not RB cord-312840-jvdph782 154 33 been be VBN cord-312840-jvdph782 154 34 recognized recognize VBN cord-312840-jvdph782 154 35 and and CC cord-312840-jvdph782 154 36 corrected correct VBN cord-312840-jvdph782 154 37 for for IN cord-312840-jvdph782 154 38 in in IN cord-312840-jvdph782 154 39 other other JJ cord-312840-jvdph782 154 40 analyses analysis NNS cord-312840-jvdph782 154 41 that that WDT cord-312840-jvdph782 154 42 we -PRON- PRP cord-312840-jvdph782 154 43 are be VBP cord-312840-jvdph782 154 44 aware aware JJ cord-312840-jvdph782 154 45 of of IN cord-312840-jvdph782 154 46 . . . cord-312840-jvdph782 155 1 Brooks Brooks NNP cord-312840-jvdph782 155 2 - - HYPH cord-312840-jvdph782 155 3 Pollock Pollock NNP cord-312840-jvdph782 155 4 et et NNP cord-312840-jvdph782 155 5 al al NNP cord-312840-jvdph782 155 6 . . . cord-312840-jvdph782 156 1 [ [ -LRB- cord-312840-jvdph782 156 2 23 23 CD cord-312840-jvdph782 156 3 ] ] -RRB- cord-312840-jvdph782 156 4 report report NN cord-312840-jvdph782 156 5 results result NNS cord-312840-jvdph782 156 6 from from IN cord-312840-jvdph782 156 7 a a DT cord-312840-jvdph782 156 8 survey survey NN cord-312840-jvdph782 156 9 conducted conduct VBN cord-312840-jvdph782 156 10 during during IN cord-312840-jvdph782 156 11 the the DT cord-312840-jvdph782 156 12 2009 2009 CD cord-312840-jvdph782 156 13 H1N1 H1N1 NNP cord-312840-jvdph782 156 14 Influenza Influenza NNP cord-312840-jvdph782 156 15 pandemic pandemic NN cord-312840-jvdph782 156 16 in in IN cord-312840-jvdph782 156 17 the the DT cord-312840-jvdph782 156 18 UK UK NNP cord-312840-jvdph782 156 19 that that WDT cord-312840-jvdph782 156 20 showed show VBD cord-312840-jvdph782 156 21 that that IN cord-312840-jvdph782 156 22 the the DT cord-312840-jvdph782 156 23 very very RB cord-312840-jvdph782 156 24 young young JJ cord-312840-jvdph782 156 25 and and CC cord-312840-jvdph782 156 26 very very RB cord-312840-jvdph782 156 27 old old JJ cord-312840-jvdph782 156 28 were be VBD cord-312840-jvdph782 156 29 more more RBR cord-312840-jvdph782 156 30 likely likely JJ cord-312840-jvdph782 156 31 to to TO cord-312840-jvdph782 156 32 seek seek VB cord-312840-jvdph782 156 33 healthcare healthcare NN cord-312840-jvdph782 156 34 when when WRB cord-312840-jvdph782 156 35 ill ill JJ cord-312840-jvdph782 156 36 . . . cord-312840-jvdph782 157 1 The the DT cord-312840-jvdph782 157 2 impact impact NN cord-312840-jvdph782 157 3 of of IN cord-312840-jvdph782 157 4 correcting correct VBG cord-312840-jvdph782 157 5 surveillance surveillance NN cord-312840-jvdph782 157 6 data datum NNS cord-312840-jvdph782 157 7 to to TO cord-312840-jvdph782 157 8 accommodate accommodate VB cord-312840-jvdph782 157 9 this this DT cord-312840-jvdph782 157 10 phenomenon phenomenon NN cord-312840-jvdph782 157 11 was be VBD cord-312840-jvdph782 157 12 to to TO cord-312840-jvdph782 157 13 shift shift VB cord-312840-jvdph782 157 14 the the DT cord-312840-jvdph782 157 15 burden burden NN cord-312840-jvdph782 157 16 of of IN cord-312840-jvdph782 157 17 illness illness NN cord-312840-jvdph782 157 18 from from IN cord-312840-jvdph782 157 19 the the DT cord-312840-jvdph782 157 20 very very RB cord-312840-jvdph782 157 21 young young JJ cord-312840-jvdph782 157 22 to to IN cord-312840-jvdph782 157 23 the the DT cord-312840-jvdph782 157 24 middle middle NN cord-312840-jvdph782 157 25 - - HYPH cord-312840-jvdph782 157 26 aged aged JJ cord-312840-jvdph782 157 27 . . . cord-312840-jvdph782 158 1 Further further JJ cord-312840-jvdph782 158 2 investigation investigation NN cord-312840-jvdph782 158 3 into into IN cord-312840-jvdph782 158 4 potential potential JJ cord-312840-jvdph782 158 5 reporting reporting NN cord-312840-jvdph782 158 6 inconsistencies inconsistency NNS cord-312840-jvdph782 158 7 is be VBZ cord-312840-jvdph782 158 8 important important JJ cord-312840-jvdph782 158 9 to to TO cord-312840-jvdph782 158 10 better better RB cord-312840-jvdph782 158 11 understand understand VB cord-312840-jvdph782 158 12 infectious infectious JJ cord-312840-jvdph782 158 13 disease disease NN cord-312840-jvdph782 158 14 dynamics dynamic NNS cord-312840-jvdph782 158 15 by by IN cord-312840-jvdph782 158 16 age age NN cord-312840-jvdph782 158 17 similar similar JJ cord-312840-jvdph782 158 18 to to IN cord-312840-jvdph782 158 19 what what WP cord-312840-jvdph782 158 20 was be VBD cord-312840-jvdph782 158 21 previously previously RB cord-312840-jvdph782 158 22 done do VBN cord-312840-jvdph782 158 23 but but CC cord-312840-jvdph782 158 24 not not RB cord-312840-jvdph782 158 25 incorporating incorporate VBG cord-312840-jvdph782 158 26 age age NN cord-312840-jvdph782 158 27 [ [ -LRB- cord-312840-jvdph782 158 28 27 27 CD cord-312840-jvdph782 158 29 ] ] -RRB- cord-312840-jvdph782 158 30 . . . cord-312840-jvdph782 159 1 Another another DT cord-312840-jvdph782 159 2 reporting reporting NN cord-312840-jvdph782 159 3 issue issue NN cord-312840-jvdph782 159 4 arises arise VBZ cord-312840-jvdph782 159 5 from from IN cord-312840-jvdph782 159 6 silent silent JJ cord-312840-jvdph782 159 7 infections infection NNS cord-312840-jvdph782 159 8 , , , cord-312840-jvdph782 159 9 or or CC cord-312840-jvdph782 159 10 those those DT cord-312840-jvdph782 159 11 who who WP cord-312840-jvdph782 159 12 carry carry VBP cord-312840-jvdph782 159 13 infection infection NN cord-312840-jvdph782 159 14 and and CC cord-312840-jvdph782 159 15 have have VB cord-312840-jvdph782 159 16 the the DT cord-312840-jvdph782 159 17 potential potential NN cord-312840-jvdph782 159 18 to to TO cord-312840-jvdph782 159 19 transmit transmit VB cord-312840-jvdph782 159 20 it -PRON- PRP cord-312840-jvdph782 159 21 , , , cord-312840-jvdph782 159 22 but but CC cord-312840-jvdph782 159 23 are be VBP cord-312840-jvdph782 159 24 asymptomatic asymptomatic JJ cord-312840-jvdph782 159 25 . . . cord-312840-jvdph782 160 1 We -PRON- PRP cord-312840-jvdph782 160 2 did do VBD cord-312840-jvdph782 160 3 not not RB cord-312840-jvdph782 160 4 investigate investigate VB cord-312840-jvdph782 160 5 the the DT cord-312840-jvdph782 160 6 impact impact NN cord-312840-jvdph782 160 7 of of IN cord-312840-jvdph782 160 8 these these DT cord-312840-jvdph782 160 9 individuals individual NNS cord-312840-jvdph782 160 10 , , , cord-312840-jvdph782 160 11 though though IN cord-312840-jvdph782 160 12 the the DT cord-312840-jvdph782 160 13 issues issue NNS cord-312840-jvdph782 160 14 are be VBP cord-312840-jvdph782 160 15 similar similar JJ cord-312840-jvdph782 160 16 to to IN cord-312840-jvdph782 160 17 those those DT cord-312840-jvdph782 160 18 we -PRON- PRP cord-312840-jvdph782 160 19 have have VBP cord-312840-jvdph782 160 20 just just RB cord-312840-jvdph782 160 21 described describe VBN cord-312840-jvdph782 160 22 . . . cord-312840-jvdph782 161 1 Additional additional JJ cord-312840-jvdph782 161 2 reporting reporting NN cord-312840-jvdph782 161 3 inconsistencies inconsistency NNS cord-312840-jvdph782 161 4 are be VBP cord-312840-jvdph782 161 5 possible possible JJ cord-312840-jvdph782 161 6 spatially spatially RB cord-312840-jvdph782 161 7 or or CC cord-312840-jvdph782 161 8 across across IN cord-312840-jvdph782 161 9 other other JJ cord-312840-jvdph782 161 10 socio socio JJ cord-312840-jvdph782 161 11 - - HYPH cord-312840-jvdph782 161 12 economic economic JJ cord-312840-jvdph782 161 13 factors factor NNS cord-312840-jvdph782 161 14 . . . cord-312840-jvdph782 162 1 Our -PRON- PRP$ cord-312840-jvdph782 162 2 analysis analysis NN cord-312840-jvdph782 162 3 was be VBD cord-312840-jvdph782 162 4 only only RB cord-312840-jvdph782 162 5 performed perform VBN cord-312840-jvdph782 162 6 on on IN cord-312840-jvdph782 162 7 data datum NNS cord-312840-jvdph782 162 8 from from IN cord-312840-jvdph782 162 9 Gauteng Gauteng NNP cord-312840-jvdph782 162 10 province province NN cord-312840-jvdph782 162 11 , , , cord-312840-jvdph782 162 12 the the DT cord-312840-jvdph782 162 13 most most RBS cord-312840-jvdph782 162 14 urban urban JJ cord-312840-jvdph782 162 15 province province NN cord-312840-jvdph782 162 16 in in IN cord-312840-jvdph782 162 17 South South NNP cord-312840-jvdph782 162 18 Africa Africa NNP cord-312840-jvdph782 162 19 . . . cord-312840-jvdph782 163 1 It -PRON- PRP cord-312840-jvdph782 163 2 is be VBZ cord-312840-jvdph782 163 3 possible possible JJ cord-312840-jvdph782 163 4 that that IN cord-312840-jvdph782 163 5 reporting reporting NN cord-312840-jvdph782 163 6 would would MD cord-312840-jvdph782 163 7 not not RB cord-312840-jvdph782 163 8 be be VB cord-312840-jvdph782 163 9 as as RB cord-312840-jvdph782 163 10 dramatically dramatically RB cord-312840-jvdph782 163 11 variable variable JJ cord-312840-jvdph782 163 12 as as IN cord-312840-jvdph782 163 13 it -PRON- PRP cord-312840-jvdph782 163 14 would would MD cord-312840-jvdph782 163 15 be be VB cord-312840-jvdph782 163 16 if if IN cord-312840-jvdph782 163 17 we -PRON- PRP cord-312840-jvdph782 163 18 were be VBD cord-312840-jvdph782 163 19 to to TO cord-312840-jvdph782 163 20 make make VB cord-312840-jvdph782 163 21 use use NN cord-312840-jvdph782 163 22 of of IN cord-312840-jvdph782 163 23 data datum NNS cord-312840-jvdph782 163 24 from from IN cord-312840-jvdph782 163 25 the the DT cord-312840-jvdph782 163 26 entire entire JJ cord-312840-jvdph782 163 27 country country NN cord-312840-jvdph782 163 28 . . . cord-312840-jvdph782 164 1 It -PRON- PRP cord-312840-jvdph782 164 2 is be VBZ cord-312840-jvdph782 164 3 also also RB cord-312840-jvdph782 164 4 important important JJ cord-312840-jvdph782 164 5 to to TO cord-312840-jvdph782 164 6 note note VB cord-312840-jvdph782 164 7 that that IN cord-312840-jvdph782 164 8 we -PRON- PRP cord-312840-jvdph782 164 9 chose choose VBD cord-312840-jvdph782 164 10 to to TO cord-312840-jvdph782 164 11 limit limit VB cord-312840-jvdph782 164 12 our -PRON- PRP$ cord-312840-jvdph782 164 13 analysis analysis NN cord-312840-jvdph782 164 14 to to IN cord-312840-jvdph782 164 15 Gauteng Gauteng NNP cord-312840-jvdph782 164 16 province province NN cord-312840-jvdph782 164 17 so so IN cord-312840-jvdph782 164 18 as as IN cord-312840-jvdph782 164 19 to to TO cord-312840-jvdph782 164 20 limit limit VB cord-312840-jvdph782 164 21 the the DT cord-312840-jvdph782 164 22 impact impact NN cord-312840-jvdph782 164 23 of of IN cord-312840-jvdph782 164 24 spatial spatial JJ cord-312840-jvdph782 164 25 effects effect NNS cord-312840-jvdph782 164 26 and and CC cord-312840-jvdph782 164 27 make make VB cord-312840-jvdph782 164 28 the the DT cord-312840-jvdph782 164 29 assumption assumption NN cord-312840-jvdph782 164 30 of of IN cord-312840-jvdph782 164 31 homogenous homogenous JJ cord-312840-jvdph782 164 32 mixing mix VBG cord-312840-jvdph782 164 33 more more RBR cord-312840-jvdph782 164 34 reasonable reasonable JJ cord-312840-jvdph782 164 35 . . . cord-312840-jvdph782 165 1 This this DT cord-312840-jvdph782 165 2 could could MD cord-312840-jvdph782 165 3 limit limit VB cord-312840-jvdph782 165 4 generalizability generalizability NN cord-312840-jvdph782 165 5 . . . cord-312840-jvdph782 166 1 We -PRON- PRP cord-312840-jvdph782 166 2 have have VBP cord-312840-jvdph782 166 3 also also RB cord-312840-jvdph782 166 4 assumed assume VBN cord-312840-jvdph782 166 5 that that IN cord-312840-jvdph782 166 6 the the DT cord-312840-jvdph782 166 7 contact contact NN cord-312840-jvdph782 166 8 matrices matrix NNS cord-312840-jvdph782 166 9 we -PRON- PRP cord-312840-jvdph782 166 10 use use VBP cord-312840-jvdph782 166 11 are be VBP cord-312840-jvdph782 166 12 correct correct JJ cord-312840-jvdph782 166 13 and and CC cord-312840-jvdph782 166 14 do do VBP cord-312840-jvdph782 166 15 not not RB cord-312840-jvdph782 166 16 allow allow VB cord-312840-jvdph782 166 17 for for IN cord-312840-jvdph782 166 18 any any DT cord-312840-jvdph782 166 19 uncertainty uncertainty NN cord-312840-jvdph782 166 20 in in IN cord-312840-jvdph782 166 21 their -PRON- PRP$ cord-312840-jvdph782 166 22 estimation estimation NN cord-312840-jvdph782 166 23 . . . cord-312840-jvdph782 167 1 These these DT cord-312840-jvdph782 167 2 results result NNS cord-312840-jvdph782 167 3 might may MD cord-312840-jvdph782 167 4 be be VB cord-312840-jvdph782 167 5 improved improve VBN cord-312840-jvdph782 167 6 upon upon IN cord-312840-jvdph782 167 7 and and CC cord-312840-jvdph782 167 8 made make VBD cord-312840-jvdph782 167 9 more more RBR cord-312840-jvdph782 167 10 realistic realistic JJ cord-312840-jvdph782 167 11 by by IN cord-312840-jvdph782 167 12 allowing allow VBG cord-312840-jvdph782 167 13 for for IN cord-312840-jvdph782 167 14 greater great JJR cord-312840-jvdph782 167 15 stochastic stochastic JJ cord-312840-jvdph782 167 16 effects effect NNS cord-312840-jvdph782 167 17 and/or and/or CC cord-312840-jvdph782 167 18 flexibility flexibility NN cord-312840-jvdph782 167 19 in in IN cord-312840-jvdph782 167 20 the the DT cord-312840-jvdph782 167 21 transmission transmission NN cord-312840-jvdph782 167 22 matrix matrix NN cord-312840-jvdph782 167 23 . . . cord-312840-jvdph782 168 1 Ideally ideally RB cord-312840-jvdph782 168 2 we -PRON- PRP cord-312840-jvdph782 168 3 would would MD cord-312840-jvdph782 168 4 estimate estimate VB cord-312840-jvdph782 168 5 these these DT cord-312840-jvdph782 168 6 parameters parameter NNS cord-312840-jvdph782 168 7 in in IN cord-312840-jvdph782 168 8 our -PRON- PRP$ cord-312840-jvdph782 168 9 study study NN cord-312840-jvdph782 168 10 , , , cord-312840-jvdph782 168 11 but but CC cord-312840-jvdph782 168 12 we -PRON- PRP cord-312840-jvdph782 168 13 do do VBP cord-312840-jvdph782 168 14 not not RB cord-312840-jvdph782 168 15 have have VB cord-312840-jvdph782 168 16 sufficient sufficient JJ cord-312840-jvdph782 168 17 data datum NNS cord-312840-jvdph782 168 18 to to TO cord-312840-jvdph782 168 19 do do VB cord-312840-jvdph782 168 20 so so RB cord-312840-jvdph782 168 21 in in IN cord-312840-jvdph782 168 22 the the DT cord-312840-jvdph782 168 23 present present JJ cord-312840-jvdph782 168 24 framework framework NN cord-312840-jvdph782 168 25 . . . cord-312840-jvdph782 169 1 Glass Glass NNP cord-312840-jvdph782 169 2 et et FW cord-312840-jvdph782 169 3 al al NNP cord-312840-jvdph782 169 4 . . . cord-312840-jvdph782 170 1 [ [ -LRB- cord-312840-jvdph782 170 2 2 2 LS cord-312840-jvdph782 170 3 ] ] -RRB- cord-312840-jvdph782 170 4 have have VBP cord-312840-jvdph782 170 5 shown show VBN cord-312840-jvdph782 170 6 how how WRB cord-312840-jvdph782 170 7 to to TO cord-312840-jvdph782 170 8 do do VB cord-312840-jvdph782 170 9 this this DT cord-312840-jvdph782 170 10 for for IN cord-312840-jvdph782 170 11 a a DT cord-312840-jvdph782 170 12 matrix matrix NN cord-312840-jvdph782 170 13 with with IN cord-312840-jvdph782 170 14 adults adult NNS cord-312840-jvdph782 170 15 and and CC cord-312840-jvdph782 170 16 children child NNS cord-312840-jvdph782 170 17 , , , cord-312840-jvdph782 170 18 but but CC cord-312840-jvdph782 170 19 are be VBP cord-312840-jvdph782 170 20 limited limit VBN cord-312840-jvdph782 170 21 to to IN cord-312840-jvdph782 170 22 two two CD cord-312840-jvdph782 170 23 by by IN cord-312840-jvdph782 170 24 two two CD cord-312840-jvdph782 170 25 matrices matrix NNS cord-312840-jvdph782 170 26 that that WDT cord-312840-jvdph782 170 27 presume presume VBP cord-312840-jvdph782 170 28 a a DT cord-312840-jvdph782 170 29 pre pre JJ cord-312840-jvdph782 170 30 - - JJ cord-312840-jvdph782 170 31 specified specified JJ cord-312840-jvdph782 170 32 structure structure NN cord-312840-jvdph782 170 33 and and CC cord-312840-jvdph782 170 34 are be VBP cord-312840-jvdph782 170 35 unable unable JJ cord-312840-jvdph782 170 36 to to TO cord-312840-jvdph782 170 37 consider consider VB cord-312840-jvdph782 170 38 a a DT cord-312840-jvdph782 170 39 larger large JJR cord-312840-jvdph782 170 40 number number NN cord-312840-jvdph782 170 41 of of IN cord-312840-jvdph782 170 42 age age NN cord-312840-jvdph782 170 43 groups group NNS cord-312840-jvdph782 170 44 , , , cord-312840-jvdph782 170 45 thus thus RB cord-312840-jvdph782 170 46 limiting limit VBG cord-312840-jvdph782 170 47 their -PRON- PRP$ cord-312840-jvdph782 170 48 ability ability NN cord-312840-jvdph782 170 49 to to TO cord-312840-jvdph782 170 50 gain gain VB cord-312840-jvdph782 170 51 a a DT cord-312840-jvdph782 170 52 more more RBR cord-312840-jvdph782 170 53 thorough thorough JJ cord-312840-jvdph782 170 54 and and CC cord-312840-jvdph782 170 55 detailed detailed JJ cord-312840-jvdph782 170 56 understanding understanding NN cord-312840-jvdph782 170 57 of of IN cord-312840-jvdph782 170 58 transmission transmission NN cord-312840-jvdph782 170 59 . . . cord-312840-jvdph782 171 1 We -PRON- PRP cord-312840-jvdph782 171 2 have have VBP cord-312840-jvdph782 171 3 applied apply VBN cord-312840-jvdph782 171 4 a a DT cord-312840-jvdph782 171 5 novel novel JJ cord-312840-jvdph782 171 6 method method NN cord-312840-jvdph782 171 7 to to TO cord-312840-jvdph782 171 8 estimate estimate VB cord-312840-jvdph782 171 9 transmission transmission NN cord-312840-jvdph782 171 10 patterns pattern NNS cord-312840-jvdph782 171 11 between between IN cord-312840-jvdph782 171 12 individuals individual NNS cord-312840-jvdph782 171 13 from from IN cord-312840-jvdph782 171 14 different different JJ cord-312840-jvdph782 171 15 age age NN cord-312840-jvdph782 171 16 groups group NNS cord-312840-jvdph782 171 17 during during IN cord-312840-jvdph782 171 18 the the DT cord-312840-jvdph782 171 19 2009 2009 CD cord-312840-jvdph782 171 20 Influenza Influenza NNP cord-312840-jvdph782 171 21 H1N1pdm H1N1pdm NNP cord-312840-jvdph782 171 22 in in IN cord-312840-jvdph782 171 23 South South NNP cord-312840-jvdph782 171 24 Africa Africa NNP cord-312840-jvdph782 171 25 . . . cord-312840-jvdph782 172 1 We -PRON- PRP cord-312840-jvdph782 172 2 show show VBP cord-312840-jvdph782 172 3 that that IN cord-312840-jvdph782 172 4 assumptions assumption NNS cord-312840-jvdph782 172 5 regarding regard VBG cord-312840-jvdph782 172 6 the the DT cord-312840-jvdph782 172 7 assumed assume VBN cord-312840-jvdph782 172 8 contact contact NN cord-312840-jvdph782 172 9 patterns pattern NNS cord-312840-jvdph782 172 10 between between IN cord-312840-jvdph782 172 11 age age NN cord-312840-jvdph782 172 12 groups group NNS cord-312840-jvdph782 172 13 do do VBP cord-312840-jvdph782 172 14 not not RB cord-312840-jvdph782 172 15 substantially substantially RB cord-312840-jvdph782 172 16 impact impact VB cord-312840-jvdph782 172 17 the the DT cord-312840-jvdph782 172 18 conclusions conclusion NNS cord-312840-jvdph782 172 19 one one PRP cord-312840-jvdph782 172 20 draws draw VBZ cord-312840-jvdph782 172 21 from from IN cord-312840-jvdph782 172 22 the the DT cord-312840-jvdph782 172 23 data data NN cord-312840-jvdph782 172 24 analyses analysis NNS cord-312840-jvdph782 172 25 in in IN cord-312840-jvdph782 172 26 our -PRON- PRP$ cord-312840-jvdph782 172 27 study study NN cord-312840-jvdph782 172 28 . . . cord-312840-jvdph782 173 1 Our -PRON- PRP$ cord-312840-jvdph782 173 2 results result NNS cord-312840-jvdph782 173 3 are be VBP cord-312840-jvdph782 173 4 consistent consistent JJ cord-312840-jvdph782 173 5 with with IN cord-312840-jvdph782 173 6 other other JJ cord-312840-jvdph782 173 7 studies study NNS cord-312840-jvdph782 173 8 that that WDT cord-312840-jvdph782 173 9 show show VBP cord-312840-jvdph782 173 10 children child NNS cord-312840-jvdph782 173 11 are be VBP cord-312840-jvdph782 173 12 much much RB cord-312840-jvdph782 173 13 more more RBR cord-312840-jvdph782 173 14 likely likely JJ cord-312840-jvdph782 173 15 to to TO cord-312840-jvdph782 173 16 become become VB cord-312840-jvdph782 173 17 ill ill JJ cord-312840-jvdph782 173 18 and and CC cord-312840-jvdph782 173 19 transmit transmit VB cord-312840-jvdph782 173 20 disease disease NN cord-312840-jvdph782 173 21 than than IN cord-312840-jvdph782 173 22 adults adult NNS cord-312840-jvdph782 173 23 during during IN cord-312840-jvdph782 173 24 a a DT cord-312840-jvdph782 173 25 pandemic pandemic NN cord-312840-jvdph782 173 26 , , , cord-312840-jvdph782 173 27 if if IN cord-312840-jvdph782 173 28 the the DT cord-312840-jvdph782 173 29 completeness completeness NN cord-312840-jvdph782 173 30 of of IN cord-312840-jvdph782 173 31 the the DT cord-312840-jvdph782 173 32 data datum NNS cord-312840-jvdph782 173 33 reported report VBN cord-312840-jvdph782 173 34 is be VBZ cord-312840-jvdph782 173 35 independent independent JJ cord-312840-jvdph782 173 36 of of IN cord-312840-jvdph782 173 37 the the DT cord-312840-jvdph782 173 38 age age NN cord-312840-jvdph782 173 39 of of IN cord-312840-jvdph782 173 40 the the DT cord-312840-jvdph782 173 41 patients patient NNS cord-312840-jvdph782 173 42 . . . cord-312840-jvdph782 174 1 These these DT cord-312840-jvdph782 174 2 methods method NNS cord-312840-jvdph782 174 3 can can MD cord-312840-jvdph782 174 4 be be VB cord-312840-jvdph782 174 5 used use VBN cord-312840-jvdph782 174 6 to to TO cord-312840-jvdph782 174 7 estimate estimate VB cord-312840-jvdph782 174 8 heterogeneity heterogeneity NN cord-312840-jvdph782 174 9 in in IN cord-312840-jvdph782 174 10 transmission transmission NN cord-312840-jvdph782 174 11 parameters parameter NNS cord-312840-jvdph782 174 12 in in IN cord-312840-jvdph782 174 13 real real JJ cord-312840-jvdph782 174 14 time time NN cord-312840-jvdph782 174 15 by by IN cord-312840-jvdph782 174 16 using use VBG cord-312840-jvdph782 174 17 the the DT cord-312840-jvdph782 174 18 modification modification NN cord-312840-jvdph782 174 19 proposed propose VBN cord-312840-jvdph782 174 20 by by IN cord-312840-jvdph782 174 21 Cauchemez Cauchemez NNP cord-312840-jvdph782 174 22 et et NNP cord-312840-jvdph782 174 23 al al NNP cord-312840-jvdph782 174 24 . . . cord-312840-jvdph782 175 1 [ [ -LRB- cord-312840-jvdph782 175 2 30 30 CD cord-312840-jvdph782 175 3 ] ] -RRB- cord-312840-jvdph782 175 4 and and CC cord-312840-jvdph782 175 5 thus thus RB cord-312840-jvdph782 175 6 inform inform VB cord-312840-jvdph782 175 7 the the DT cord-312840-jvdph782 175 8 use use NN cord-312840-jvdph782 175 9 of of IN cord-312840-jvdph782 175 10 targeted target VBN cord-312840-jvdph782 175 11 interventions intervention NNS cord-312840-jvdph782 175 12 by by IN cord-312840-jvdph782 175 13 age age NN cord-312840-jvdph782 175 14 group group NN cord-312840-jvdph782 175 15 . . . cord-312840-jvdph782 176 1 Wallinga Wallinga NNP cord-312840-jvdph782 176 2 and and CC cord-312840-jvdph782 176 3 Teunis Teunis NNP cord-312840-jvdph782 176 4 ( ( -LRB- cord-312840-jvdph782 176 5 20 20 CD cord-312840-jvdph782 176 6 ) ) -RRB- cord-312840-jvdph782 177 1 ( ( -LRB- cord-312840-jvdph782 177 2 denoted denoted JJ cord-312840-jvdph782 177 3 WT WT NNP cord-312840-jvdph782 177 4 method method NN cord-312840-jvdph782 177 5 hereafter hereafter RB cord-312840-jvdph782 177 6 ) ) -RRB- cord-312840-jvdph782 177 7 proposed propose VBD cord-312840-jvdph782 177 8 a a DT cord-312840-jvdph782 177 9 method method NN cord-312840-jvdph782 177 10 for for IN cord-312840-jvdph782 177 11 the the DT cord-312840-jvdph782 177 12 estimation estimation NN cord-312840-jvdph782 177 13 of of IN cord-312840-jvdph782 177 14 the the DT cord-312840-jvdph782 177 15 effective effective JJ cord-312840-jvdph782 177 16 reproductive reproductive JJ cord-312840-jvdph782 177 17 number number NN cord-312840-jvdph782 177 18 by by IN cord-312840-jvdph782 177 19 making make VBG cord-312840-jvdph782 177 20 use use NN cord-312840-jvdph782 177 21 of of IN cord-312840-jvdph782 177 22 the the DT cord-312840-jvdph782 177 23 epidemic epidemic NN cord-312840-jvdph782 177 24 curve curve NN cord-312840-jvdph782 177 25 , , , cord-312840-jvdph782 177 26 N n NN cord-312840-jvdph782 177 27 = = NN cord-312840-jvdph782 177 28 { { -LRB- cord-312840-jvdph782 177 29 N N NNP cord-312840-jvdph782 177 30 1 1 CD cord-312840-jvdph782 177 31 , , , cord-312840-jvdph782 177 32 … … NFP cord-312840-jvdph782 177 33 , , , cord-312840-jvdph782 177 34 N N NNP cord-312840-jvdph782 177 35 T T NNP cord-312840-jvdph782 177 36 } } -RRB- cord-312840-jvdph782 177 37 , , , cord-312840-jvdph782 177 38 where where WRB cord-312840-jvdph782 177 39 N N NNP cord-312840-jvdph782 177 40 t t NN cord-312840-jvdph782 177 41 is be VBZ cord-312840-jvdph782 177 42 the the DT cord-312840-jvdph782 177 43 number number NN cord-312840-jvdph782 177 44 of of IN cord-312840-jvdph782 177 45 cases case NNS cord-312840-jvdph782 177 46 at at IN cord-312840-jvdph782 177 47 time time NN cord-312840-jvdph782 177 48 point point NN cord-312840-jvdph782 177 49 t t NNP cord-312840-jvdph782 177 50 , , , cord-312840-jvdph782 177 51 and and CC cord-312840-jvdph782 177 52 an an DT cord-312840-jvdph782 177 53 estimate estimate NN cord-312840-jvdph782 177 54 of of IN cord-312840-jvdph782 177 55 the the DT cord-312840-jvdph782 177 56 serial serial JJ cord-312840-jvdph782 177 57 interval interval NN cord-312840-jvdph782 177 58 , , , cord-312840-jvdph782 177 59 p p NN cord-312840-jvdph782 177 60 1 1 CD cord-312840-jvdph782 177 61 , , , cord-312840-jvdph782 177 62 … … NFP cord-312840-jvdph782 177 63 , , , cord-312840-jvdph782 177 64 p p NN cord-312840-jvdph782 177 65 k k NN cord-312840-jvdph782 177 66 , , , cord-312840-jvdph782 177 67 where where WRB cord-312840-jvdph782 177 68 p p NNP cord-312840-jvdph782 177 69 i i PRP cord-312840-jvdph782 177 70 describes describe VBZ cord-312840-jvdph782 177 71 the the DT cord-312840-jvdph782 177 72 probability probability NN cord-312840-jvdph782 177 73 of of IN cord-312840-jvdph782 177 74 a a DT cord-312840-jvdph782 177 75 serial serial JJ cord-312840-jvdph782 177 76 interval interval NN cord-312840-jvdph782 177 77 of of IN cord-312840-jvdph782 177 78 length length NN cord-312840-jvdph782 177 79 i i PRP cord-312840-jvdph782 177 80 and and CC cord-312840-jvdph782 177 81 the the DT cord-312840-jvdph782 177 82 maximum maximum JJ cord-312840-jvdph782 177 83 serial serial JJ cord-312840-jvdph782 177 84 interval interval NN cord-312840-jvdph782 177 85 length length NN cord-312840-jvdph782 177 86 is be VBZ cord-312840-jvdph782 177 87 k. k. NNP cord-312840-jvdph782 178 1 For for IN cord-312840-jvdph782 178 2 ease ease NN cord-312840-jvdph782 178 3 of of IN cord-312840-jvdph782 178 4 presentation presentation NN cord-312840-jvdph782 178 5 , , , cord-312840-jvdph782 178 6 we -PRON- PRP cord-312840-jvdph782 178 7 assume assume VBP cord-312840-jvdph782 178 8 that that IN cord-312840-jvdph782 178 9 the the DT cord-312840-jvdph782 178 10 time time NN cord-312840-jvdph782 178 11 step step NN cord-312840-jvdph782 178 12 is be VBZ cord-312840-jvdph782 178 13 a a DT cord-312840-jvdph782 178 14 day day NN cord-312840-jvdph782 178 15 . . . cord-312840-jvdph782 179 1 Individuals individual NNS cord-312840-jvdph782 179 2 are be VBP cord-312840-jvdph782 179 3 placed place VBN cord-312840-jvdph782 179 4 in in IN cord-312840-jvdph782 179 5 a a DT cord-312840-jvdph782 179 6 network network NN cord-312840-jvdph782 179 7 temporally temporally RB cord-312840-jvdph782 179 8 by by IN cord-312840-jvdph782 179 9 symptom symptom NN cord-312840-jvdph782 179 10 onset onset NN cord-312840-jvdph782 179 11 date date NN cord-312840-jvdph782 179 12 and and CC cord-312840-jvdph782 179 13 the the DT cord-312840-jvdph782 179 14 probability probability NN cord-312840-jvdph782 179 15 of of IN cord-312840-jvdph782 179 16 transmission transmission NN cord-312840-jvdph782 179 17 occurring occur VBG cord-312840-jvdph782 179 18 between between IN cord-312840-jvdph782 179 19 two two CD cord-312840-jvdph782 179 20 individuals individual NNS cord-312840-jvdph782 179 21 in in IN cord-312840-jvdph782 179 22 the the DT cord-312840-jvdph782 179 23 network network NN cord-312840-jvdph782 179 24 is be VBZ cord-312840-jvdph782 179 25 determined determine VBN cord-312840-jvdph782 179 26 by by IN cord-312840-jvdph782 179 27 the the DT cord-312840-jvdph782 179 28 serial serial JJ cord-312840-jvdph782 179 29 interval interval NN cord-312840-jvdph782 179 30 . . . cord-312840-jvdph782 180 1 The the DT cord-312840-jvdph782 180 2 calculation calculation NN cord-312840-jvdph782 180 3 of of IN cord-312840-jvdph782 180 4 R R NNP cord-312840-jvdph782 180 5 t t NN cord-312840-jvdph782 180 6 occurs occur VBZ cord-312840-jvdph782 180 7 in in IN cord-312840-jvdph782 180 8 three three CD cord-312840-jvdph782 180 9 steps step NNS cord-312840-jvdph782 180 10 . . . cord-312840-jvdph782 181 1 In in IN cord-312840-jvdph782 181 2 what what WP cord-312840-jvdph782 181 3 follows follow VBZ cord-312840-jvdph782 181 4 , , , cord-312840-jvdph782 181 5 we -PRON- PRP cord-312840-jvdph782 181 6 let let VBP cord-312840-jvdph782 181 7 t t NN cord-312840-jvdph782 182 1 i i PRP cord-312840-jvdph782 182 2 denote denote VBP cord-312840-jvdph782 182 3 the the DT cord-312840-jvdph782 182 4 i i NN cord-312840-jvdph782 182 5 th th XX cord-312840-jvdph782 182 6 individual individual NN cord-312840-jvdph782 182 7 with with IN cord-312840-jvdph782 182 8 symptom symptom NN cord-312840-jvdph782 182 9 onset onset NN cord-312840-jvdph782 182 10 on on IN cord-312840-jvdph782 182 11 day day NN cord-312840-jvdph782 182 12 t t NN cord-312840-jvdph782 182 13 , , , cord-312840-jvdph782 182 14 where where WRB cord-312840-jvdph782 182 15 i i PRP cord-312840-jvdph782 182 16 = = VBZ cord-312840-jvdph782 182 17 1, 1, NNP cord-312840-jvdph782 182 18 … … NFP cord-312840-jvdph782 182 19 ,N ,N , cord-312840-jvdph782 182 20 t t NNP cord-312840-jvdph782 182 21 . . NNP cord-312840-jvdph782 182 22 1 1 CD cord-312840-jvdph782 182 23 . . . cord-312840-jvdph782 183 1 For for IN cord-312840-jvdph782 183 2 the the DT cord-312840-jvdph782 183 3 i i NN cord-312840-jvdph782 183 4 th th DT cord-312840-jvdph782 183 5 individual individual NN cord-312840-jvdph782 183 6 with with IN cord-312840-jvdph782 183 7 symptom symptom NN cord-312840-jvdph782 183 8 onset onset NN cord-312840-jvdph782 183 9 on on IN cord-312840-jvdph782 183 10 day day NN cord-312840-jvdph782 183 11 t t NN cord-312840-jvdph782 183 12 , , , cord-312840-jvdph782 183 13 calculate calculate VB cord-312840-jvdph782 183 14 the the DT cord-312840-jvdph782 183 15 probabilities probability NNS cord-312840-jvdph782 183 16 of of IN cord-312840-jvdph782 183 17 infection infection NN cord-312840-jvdph782 183 18 by by IN cord-312840-jvdph782 183 19 all all PDT cord-312840-jvdph782 183 20 those those DT cord-312840-jvdph782 183 21 with with IN cord-312840-jvdph782 183 22 symptom symptom NN cord-312840-jvdph782 183 23 onset onset NN cord-312840-jvdph782 183 24 on on IN cord-312840-jvdph782 183 25 prior prior JJ cord-312840-jvdph782 183 26 days day NNS cord-312840-jvdph782 183 27 t t NNP cord-312840-jvdph782 183 28 2 2 CD cord-312840-jvdph782 183 29 ( ( -LRB- cord-312840-jvdph782 183 30 t2 t2 NNP cord-312840-jvdph782 183 31 < < XX cord-312840-jvdph782 183 32 t. t. NNP cord-312840-jvdph782 183 33 ) ) -RRB- cord-312840-jvdph782 184 1 These these DT cord-312840-jvdph782 184 2 probabilities probability NNS cord-312840-jvdph782 184 3 equal equal VBP cord-312840-jvdph782 184 4 the the DT cord-312840-jvdph782 184 5 serial serial JJ cord-312840-jvdph782 184 6 interval interval NN cord-312840-jvdph782 184 7 probability probability NN cord-312840-jvdph782 184 8 for for IN cord-312840-jvdph782 184 9 the the DT cord-312840-jvdph782 184 10 distance distance NN cord-312840-jvdph782 184 11 in in IN cord-312840-jvdph782 184 12 time time NN cord-312840-jvdph782 184 13 between between IN cord-312840-jvdph782 184 14 the the DT cord-312840-jvdph782 184 15 potential potential JJ cord-312840-jvdph782 184 16 infector infector NN cord-312840-jvdph782 184 17 , , , cord-312840-jvdph782 184 18 t t NNP cord-312840-jvdph782 184 19 j j NNP cord-312840-jvdph782 184 20 2 2 CD cord-312840-jvdph782 184 21 , , , cord-312840-jvdph782 184 22 and and CC cord-312840-jvdph782 184 23 infectee infectee NNP cord-312840-jvdph782 184 24 , , , cord-312840-jvdph782 184 25 t t NNP cord-312840-jvdph782 184 26 i i NNP cord-312840-jvdph782 184 27 , , , cord-312840-jvdph782 184 28 P P NNP cord-312840-jvdph782 184 29 ( ( -LRB- cord-312840-jvdph782 184 30 t t NNP cord-312840-jvdph782 184 31 j j NNP cord-312840-jvdph782 184 32 ' ' '' cord-312840-jvdph782 184 33 →t →t NNP cord-312840-jvdph782 184 34 i i NN cord-312840-jvdph782 184 35 ) ) -RRB- cord-312840-jvdph782 184 36 = = NFP cord-312840-jvdph782 185 1 p p NN cord-312840-jvdph782 185 2 t t NNP cord-312840-jvdph782 185 3 i i NNP cord-312840-jvdph782 185 4 −t −t NNP cord-312840-jvdph782 185 5 0 0 CD cord-312840-jvdph782 185 6 j j NNP cord-312840-jvdph782 185 7 . . . cord-312840-jvdph782 186 1 Calculate calculate VB cord-312840-jvdph782 186 2 the the DT cord-312840-jvdph782 186 3 relative relative JJ cord-312840-jvdph782 186 4 probability probability NN cord-312840-jvdph782 186 5 that that IN cord-312840-jvdph782 186 6 the the DT cord-312840-jvdph782 186 7 case case NN cord-312840-jvdph782 186 8 t t NN cord-312840-jvdph782 186 9 i i PRP cord-312840-jvdph782 186 10 was be VBD cord-312840-jvdph782 186 11 infected infect VBN cord-312840-jvdph782 186 12 by by IN cord-312840-jvdph782 186 13 the the DT cord-312840-jvdph782 186 14 j j NNP cord-312840-jvdph782 186 15 th th XX cord-312840-jvdph782 186 16 case case NN cord-312840-jvdph782 186 17 on on IN cord-312840-jvdph782 186 18 day day NN cord-312840-jvdph782 186 19 P p NN cord-312840-jvdph782 187 1 ( ( -LRB- cord-312840-jvdph782 187 2 t t NNP cord-312840-jvdph782 187 3 j j NNP cord-312840-jvdph782 187 4 ' ' '' cord-312840-jvdph782 187 5 →t →t NNP cord-312840-jvdph782 187 6 i i NN cord-312840-jvdph782 187 7 ) ) -RRB- cord-312840-jvdph782 187 8 , , , cord-312840-jvdph782 187 9 denoted denote VBN cord-312840-jvdph782 187 10 by by IN cord-312840-jvdph782 187 11 q q NNP cord-312840-jvdph782 187 12 t t NNP cord-312840-jvdph782 187 13 i i NNP cord-312840-jvdph782 187 14 ; ; : cord-312840-jvdph782 187 15 t t NNP cord-312840-jvdph782 187 16 j j NNP cord-312840-jvdph782 187 17 0 0 NNP cord-312840-jvdph782 187 18 , , , cord-312840-jvdph782 187 19 q q NNP cord-312840-jvdph782 187 20 t t NNP cord-312840-jvdph782 187 21 i i NN cord-312840-jvdph782 187 22 ; ; : cord-312840-jvdph782 187 23 t t NNP cord-312840-jvdph782 187 24 j j NNP cord-312840-jvdph782 187 25 0 0 CD cord-312840-jvdph782 187 26 ¼ ¼ NNP cord-312840-jvdph782 188 1 where where WRB cord-312840-jvdph782 188 2 n n NNP cord-312840-jvdph782 188 3 s s NNP cord-312840-jvdph782 188 4 denotes denote VBZ cord-312840-jvdph782 188 5 the the DT cord-312840-jvdph782 188 6 number number NN cord-312840-jvdph782 188 7 with with IN cord-312840-jvdph782 188 8 symptom symptom NN cord-312840-jvdph782 188 9 onset onset NN cord-312840-jvdph782 188 10 on on IN cord-312840-jvdph782 188 11 day day NN cord-312840-jvdph782 188 12 s. s. NNP cord-312840-jvdph782 188 13 Sensitivity Sensitivity NNP cord-312840-jvdph782 188 14 analysis analysis NN cord-312840-jvdph782 188 15 : : : cord-312840-jvdph782 188 16 Impact impact NN cord-312840-jvdph782 188 17 of of IN cord-312840-jvdph782 188 18 errors error NNS cord-312840-jvdph782 188 19 in in IN cord-312840-jvdph782 188 20 reporting reporting NN cord-312840-jvdph782 188 21 dates date NNS cord-312840-jvdph782 189 1 In in IN cord-312840-jvdph782 189 2 this this DT cord-312840-jvdph782 189 3 analysis analysis NN cord-312840-jvdph782 189 4 , , , cord-312840-jvdph782 189 5 we -PRON- PRP cord-312840-jvdph782 189 6 choose choose VBP cord-312840-jvdph782 189 7 a a DT cord-312840-jvdph782 189 8 single single JJ cord-312840-jvdph782 189 9 imputed imputed JJ cord-312840-jvdph782 189 10 dataset dataset NN cord-312840-jvdph782 189 11 and and CC cord-312840-jvdph782 189 12 randomly randomly RB cord-312840-jvdph782 189 13 jitter jitter VBP cord-312840-jvdph782 189 14 the the DT cord-312840-jvdph782 189 15 onset onset NN cord-312840-jvdph782 189 16 dates date NNS cord-312840-jvdph782 189 17 of of IN cord-312840-jvdph782 189 18 10 10 CD cord-312840-jvdph782 189 19 % % NN cord-312840-jvdph782 189 20 of of IN cord-312840-jvdph782 189 21 the the DT cord-312840-jvdph782 189 22 sample sample NN cord-312840-jvdph782 189 23 within within IN cord-312840-jvdph782 189 24 30 30 CD cord-312840-jvdph782 189 25 days day NNS cord-312840-jvdph782 189 26 of of IN cord-312840-jvdph782 189 27 their -PRON- PRP$ cord-312840-jvdph782 189 28 observed observed JJ cord-312840-jvdph782 189 29 ( ( -LRB- cord-312840-jvdph782 189 30 or or CC cord-312840-jvdph782 189 31 imputed impute VBN cord-312840-jvdph782 189 32 ) ) -RRB- cord-312840-jvdph782 189 33 onset onset NN cord-312840-jvdph782 189 34 date date NN cord-312840-jvdph782 189 35 . . . cord-312840-jvdph782 190 1 We -PRON- PRP cord-312840-jvdph782 190 2 create create VBP cord-312840-jvdph782 190 3 50 50 CD cord-312840-jvdph782 190 4 such such JJ cord-312840-jvdph782 190 5 datasets dataset NNS cord-312840-jvdph782 190 6 and and CC cord-312840-jvdph782 190 7 repeat repeat VB cord-312840-jvdph782 190 8 all all DT cord-312840-jvdph782 190 9 analyses analysis NNS cord-312840-jvdph782 190 10 on on IN cord-312840-jvdph782 190 11 these these DT cord-312840-jvdph782 190 12 datasets dataset NNS cord-312840-jvdph782 190 13 and and CC cord-312840-jvdph782 190 14 compare compare VB cord-312840-jvdph782 190 15 them -PRON- PRP cord-312840-jvdph782 190 16 to to IN cord-312840-jvdph782 190 17 the the DT cord-312840-jvdph782 190 18 results result NNS cord-312840-jvdph782 190 19 on on IN cord-312840-jvdph782 190 20 the the DT cord-312840-jvdph782 190 21 non non JJ cord-312840-jvdph782 190 22 - - JJ cord-312840-jvdph782 190 23 jittered jittered JJ cord-312840-jvdph782 190 24 dataset dataset NN cord-312840-jvdph782 190 25 . . . cord-312840-jvdph782 191 1 Household household NN cord-312840-jvdph782 191 2 transmission transmission NN cord-312840-jvdph782 191 3 of of IN cord-312840-jvdph782 191 4 influenza influenza NN cord-312840-jvdph782 191 5 ( ( -LRB- cord-312840-jvdph782 191 6 H1N1 H1N1 NNP cord-312840-jvdph782 191 7 - - HYPH cord-312840-jvdph782 191 8 2009 2009 CD cord-312840-jvdph782 191 9 ) ) -RRB- cord-312840-jvdph782 191 10 in in IN cord-312840-jvdph782 191 11 japan japan NNP cord-312840-jvdph782 191 12 : : : cord-312840-jvdph782 191 13 age age NN cord-312840-jvdph782 191 14 - - HYPH cord-312840-jvdph782 191 15 specificity specificity NN cord-312840-jvdph782 191 16 and and CC cord-312840-jvdph782 191 17 reduction reduction NN cord-312840-jvdph782 191 18 of of IN cord-312840-jvdph782 191 19 household household NN cord-312840-jvdph782 191 20 transmission transmission NN cord-312840-jvdph782 191 21 risk risk NN cord-312840-jvdph782 191 22 by by IN cord-312840-jvdph782 191 23 zanamivir zanamivir NNP cord-312840-jvdph782 191 24 treatment treatment NNP cord-312840-jvdph782 191 25 Estimating Estimating NNP cord-312840-jvdph782 191 26 reproduction reproduction NN cord-312840-jvdph782 191 27 numbers number NNS cord-312840-jvdph782 191 28 for for IN cord-312840-jvdph782 191 29 adults adult NNS cord-312840-jvdph782 191 30 and and CC cord-312840-jvdph782 191 31 children child NNS cord-312840-jvdph782 191 32 from from IN cord-312840-jvdph782 191 33 case case NN cord-312840-jvdph782 191 34 data datum NNS cord-312840-jvdph782 191 35 Pandemic Pandemic NNP cord-312840-jvdph782 191 36 influenza influenza NN cord-312840-jvdph782 191 37 H1N1 H1N1 NNP cord-312840-jvdph782 191 38 : : : cord-312840-jvdph782 192 1 reconciling reconcile VBG cord-312840-jvdph782 192 2 serosurvey serosurvey NNP cord-312840-jvdph782 192 3 data datum NNS cord-312840-jvdph782 192 4 with with IN cord-312840-jvdph782 192 5 estimates estimate NNS cord-312840-jvdph782 192 6 of of IN cord-312840-jvdph782 192 7 the the DT cord-312840-jvdph782 192 8 reproduction reproduction NN cord-312840-jvdph782 192 9 number number NN cord-312840-jvdph782 193 1 The the DT cord-312840-jvdph782 193 2 shifting shift VBG cord-312840-jvdph782 193 3 demographic demographic JJ cord-312840-jvdph782 193 4 landscape landscape NN cord-312840-jvdph782 193 5 of of IN cord-312840-jvdph782 193 6 influenza influenza JJ cord-312840-jvdph782 193 7 Social social JJ cord-312840-jvdph782 193 8 contacts contact NNS cord-312840-jvdph782 193 9 and and CC cord-312840-jvdph782 193 10 mixing mix VBG cord-312840-jvdph782 193 11 patterns pattern NNS cord-312840-jvdph782 193 12 relevant relevant JJ cord-312840-jvdph782 193 13 to to IN cord-312840-jvdph782 193 14 the the DT cord-312840-jvdph782 193 15 spread spread NN cord-312840-jvdph782 193 16 of of IN cord-312840-jvdph782 193 17 infectious infectious JJ cord-312840-jvdph782 193 18 diseases disease NNS cord-312840-jvdph782 193 19 Age age NN cord-312840-jvdph782 193 20 - - HYPH cord-312840-jvdph782 193 21 specific specific JJ cord-312840-jvdph782 193 22 contacts contact NNS cord-312840-jvdph782 193 23 and and CC cord-312840-jvdph782 193 24 travel travel NN cord-312840-jvdph782 193 25 patterns pattern NNS cord-312840-jvdph782 193 26 in in IN cord-312840-jvdph782 193 27 the the DT cord-312840-jvdph782 193 28 spatial spatial JJ cord-312840-jvdph782 193 29 spread spread NN cord-312840-jvdph782 193 30 of of IN cord-312840-jvdph782 193 31 2009 2009 CD cord-312840-jvdph782 193 32 H1N1 H1N1 NNP cord-312840-jvdph782 193 33 influenza influenza NN cord-312840-jvdph782 193 34 pandemic pandemic NN cord-312840-jvdph782 193 35 Mixing mix VBG cord-312840-jvdph782 193 36 patterns pattern NNS cord-312840-jvdph782 193 37 between between IN cord-312840-jvdph782 193 38 age age NN cord-312840-jvdph782 193 39 groups group NNS cord-312840-jvdph782 193 40 in in IN cord-312840-jvdph782 193 41 social social JJ cord-312840-jvdph782 193 42 networks network NNS cord-312840-jvdph782 193 43 Age age NN cord-312840-jvdph782 193 44 - - HYPH cord-312840-jvdph782 193 45 dependent dependent JJ cord-312840-jvdph782 193 46 patterns pattern NNS cord-312840-jvdph782 193 47 of of IN cord-312840-jvdph782 193 48 infection infection NN cord-312840-jvdph782 193 49 and and CC cord-312840-jvdph782 193 50 severity severity NN cord-312840-jvdph782 193 51 explaining explain VBG cord-312840-jvdph782 193 52 the the DT cord-312840-jvdph782 193 53 low low JJ cord-312840-jvdph782 193 54 impact impact NN cord-312840-jvdph782 193 55 of of IN cord-312840-jvdph782 193 56 2009 2009 CD cord-312840-jvdph782 193 57 influenza influenza NN cord-312840-jvdph782 193 58 A a NN cord-312840-jvdph782 193 59 ( ( -LRB- cord-312840-jvdph782 193 60 H1N1 H1N1 NNP cord-312840-jvdph782 193 61 ) ) -RRB- cord-312840-jvdph782 194 1 : : : cord-312840-jvdph782 194 2 evidence evidence NN cord-312840-jvdph782 194 3 from from IN cord-312840-jvdph782 194 4 serial serial JJ cord-312840-jvdph782 194 5 serologic serologic JJ cord-312840-jvdph782 194 6 surveys survey NNS cord-312840-jvdph782 194 7 in in IN cord-312840-jvdph782 194 8 the the DT cord-312840-jvdph782 194 9 netherlands netherlands NNP cord-312840-jvdph782 194 10 Searching search VBG cord-312840-jvdph782 194 11 for for IN cord-312840-jvdph782 194 12 sharp sharp JJ cord-312840-jvdph782 194 13 drops drop NNS cord-312840-jvdph782 194 14 in in IN cord-312840-jvdph782 194 15 the the DT cord-312840-jvdph782 194 16 incidence incidence NN cord-312840-jvdph782 194 17 of of IN cord-312840-jvdph782 194 18 pandemic pandemic NN cord-312840-jvdph782 194 19 A A NNP cord-312840-jvdph782 194 20 / / SYM cord-312840-jvdph782 194 21 H1N1 H1N1 NNP cord-312840-jvdph782 194 22 influenza influenza NN cord-312840-jvdph782 194 23 by by IN cord-312840-jvdph782 194 24 single single JJ cord-312840-jvdph782 194 25 year year NN cord-312840-jvdph782 194 26 of of IN cord-312840-jvdph782 194 27 age age NN cord-312840-jvdph782 194 28 Close close JJ cord-312840-jvdph782 194 29 encounters encounter NNS cord-312840-jvdph782 194 30 of of IN cord-312840-jvdph782 194 31 the the DT cord-312840-jvdph782 194 32 infectious infectious JJ cord-312840-jvdph782 194 33 kind kind NN cord-312840-jvdph782 194 34 : : : cord-312840-jvdph782 194 35 methods method NNS cord-312840-jvdph782 194 36 to to TO cord-312840-jvdph782 194 37 measure measure VB cord-312840-jvdph782 194 38 social social JJ cord-312840-jvdph782 194 39 mixing mix VBG cord-312840-jvdph782 194 40 behaviour behaviour NN cord-312840-jvdph782 194 41 Social social JJ cord-312840-jvdph782 194 42 contact contact NN cord-312840-jvdph782 194 43 patterns pattern NNS cord-312840-jvdph782 194 44 in in IN cord-312840-jvdph782 194 45 vietnam vietnam NNP cord-312840-jvdph782 194 46 and and CC cord-312840-jvdph782 194 47 implications implication NNS cord-312840-jvdph782 194 48 for for IN cord-312840-jvdph782 194 49 the the DT cord-312840-jvdph782 194 50 control control NN cord-312840-jvdph782 194 51 of of IN cord-312840-jvdph782 194 52 infectious infectious JJ cord-312840-jvdph782 194 53 diseases disease NNS cord-312840-jvdph782 194 54 Social Social NNP cord-312840-jvdph782 194 55 mixing mix VBG cord-312840-jvdph782 194 56 patterns pattern NNS cord-312840-jvdph782 194 57 within within IN cord-312840-jvdph782 194 58 a a DT cord-312840-jvdph782 194 59 south south JJ cord-312840-jvdph782 194 60 african african JJ cord-312840-jvdph782 194 61 township township NN cord-312840-jvdph782 194 62 community community NN cord-312840-jvdph782 194 63 : : : cord-312840-jvdph782 194 64 implications implication NNS cord-312840-jvdph782 194 65 for for IN cord-312840-jvdph782 194 66 respiratory respiratory JJ cord-312840-jvdph782 194 67 disease disease NN cord-312840-jvdph782 194 68 transmission transmission NN cord-312840-jvdph782 194 69 and and CC cord-312840-jvdph782 194 70 control control NN cord-312840-jvdph782 194 71 Using use VBG cord-312840-jvdph782 194 72 data datum NNS cord-312840-jvdph782 194 73 on on IN cord-312840-jvdph782 194 74 social social JJ cord-312840-jvdph782 194 75 contacts contact NNS cord-312840-jvdph782 194 76 to to TO cord-312840-jvdph782 194 77 estimate estimate VB cord-312840-jvdph782 194 78 age age NN cord-312840-jvdph782 194 79 - - HYPH cord-312840-jvdph782 194 80 specific specific JJ cord-312840-jvdph782 194 81 transmission transmission NN cord-312840-jvdph782 194 82 parameters parameter NNS cord-312840-jvdph782 194 83 for for IN cord-312840-jvdph782 194 84 respiratory respiratory NN cord-312840-jvdph782 194 85 - - HYPH cord-312840-jvdph782 194 86 spread spread NN cord-312840-jvdph782 194 87 infectious infectious JJ cord-312840-jvdph782 194 88 agents agent NNS cord-312840-jvdph782 194 89 H1n1 H1n1 NNP cord-312840-jvdph782 194 90 Surveillance Surveillance NNP cord-312840-jvdph782 194 91 Group Group NNP cord-312840-jvdph782 194 92 . . . cord-312840-jvdph782 195 1 Improving improve VBG cord-312840-jvdph782 195 2 the the DT cord-312840-jvdph782 195 3 evidence evidence NN cord-312840-jvdph782 195 4 base base NN cord-312840-jvdph782 195 5 for for IN cord-312840-jvdph782 195 6 decision decision NN cord-312840-jvdph782 195 7 making making NN cord-312840-jvdph782 195 8 during during IN cord-312840-jvdph782 195 9 a a DT cord-312840-jvdph782 195 10 pandemic pandemic NN cord-312840-jvdph782 195 11 : : : cord-312840-jvdph782 195 12 the the DT cord-312840-jvdph782 195 13 example example NN cord-312840-jvdph782 195 14 of of IN cord-312840-jvdph782 195 15 2009 2009 CD cord-312840-jvdph782 195 16 influenza influenza NN cord-312840-jvdph782 195 17 A/ A/ NNP cord-312840-jvdph782 196 1 H1N1 H1N1 NNP cord-312840-jvdph782 196 2 Identifying identify VBG cord-312840-jvdph782 196 3 pediatric pediatric JJ cord-312840-jvdph782 196 4 age age NN cord-312840-jvdph782 196 5 groups group NNS cord-312840-jvdph782 196 6 for for IN cord-312840-jvdph782 196 7 influenza influenza NN cord-312840-jvdph782 196 8 vaccination vaccination NN cord-312840-jvdph782 197 1 using use VBG cord-312840-jvdph782 197 2 a a DT cord-312840-jvdph782 197 3 real real JJ cord-312840-jvdph782 197 4 - - HYPH cord-312840-jvdph782 197 5 time time NN cord-312840-jvdph782 197 6 regional regional JJ cord-312840-jvdph782 197 7 surveillance surveillance NN cord-312840-jvdph782 197 8 system system NN cord-312840-jvdph782 197 9 Age age NN cord-312840-jvdph782 197 10 - - HYPH cord-312840-jvdph782 197 11 specific specific JJ cord-312840-jvdph782 197 12 differences difference NNS cord-312840-jvdph782 197 13 in in IN cord-312840-jvdph782 197 14 influenza influenza NN cord-312840-jvdph782 197 15 A a DT cord-312840-jvdph782 197 16 epidemic epidemic NN cord-312840-jvdph782 197 17 curves curve NNS cord-312840-jvdph782 197 18 : : : cord-312840-jvdph782 197 19 do do VB cord-312840-jvdph782 197 20 children child NNS cord-312840-jvdph782 197 21 drive drive VB cord-312840-jvdph782 197 22 the the DT cord-312840-jvdph782 197 23 spread spread NN cord-312840-jvdph782 197 24 of of IN cord-312840-jvdph782 197 25 influenza influenza NN cord-312840-jvdph782 197 26 epidemics epidemic NNS cord-312840-jvdph782 197 27 ? ? . cord-312840-jvdph782 198 1 Age age NN cord-312840-jvdph782 198 2 - - HYPH cord-312840-jvdph782 198 3 related relate VBN cord-312840-jvdph782 198 4 trends trend NNS cord-312840-jvdph782 198 5 in in IN cord-312840-jvdph782 198 6 the the DT cord-312840-jvdph782 198 7 timeliness timeliness NN cord-312840-jvdph782 198 8 and and CC cord-312840-jvdph782 198 9 prediction prediction NN cord-312840-jvdph782 198 10 of of IN cord-312840-jvdph782 198 11 medical medical JJ cord-312840-jvdph782 198 12 visits visit NNS cord-312840-jvdph782 198 13 , , , cord-312840-jvdph782 198 14 hospitalizations hospitalization NNS cord-312840-jvdph782 198 15 and and CC cord-312840-jvdph782 198 16 deaths death NNS cord-312840-jvdph782 198 17 due due JJ cord-312840-jvdph782 198 18 to to IN cord-312840-jvdph782 198 19 pneumonia pneumonia NN cord-312840-jvdph782 198 20 and and CC cord-312840-jvdph782 198 21 influenza influenza NN cord-312840-jvdph782 198 22 Optimizing optimize VBG cord-312840-jvdph782 198 23 infectious infectious JJ cord-312840-jvdph782 198 24 disease disease NN cord-312840-jvdph782 198 25 interventions intervention NNS cord-312840-jvdph782 198 26 during during IN cord-312840-jvdph782 198 27 an an DT cord-312840-jvdph782 198 28 emerging emerge VBG cord-312840-jvdph782 198 29 epidemic epidemic NN cord-312840-jvdph782 198 30 Transmission transmission NN cord-312840-jvdph782 198 31 potential potential NN cord-312840-jvdph782 198 32 of of IN cord-312840-jvdph782 198 33 the the DT cord-312840-jvdph782 198 34 new new JJ cord-312840-jvdph782 198 35 influenza influenza NN cord-312840-jvdph782 198 36 A(H1N1 A(H1N1 NNP cord-312840-jvdph782 198 37 ) ) -RRB- cord-312840-jvdph782 198 38 virus virus NN cord-312840-jvdph782 198 39 and and CC cord-312840-jvdph782 198 40 its -PRON- PRP$ cord-312840-jvdph782 198 41 age age NN cord-312840-jvdph782 198 42 - - HYPH cord-312840-jvdph782 198 43 specificity specificity NN cord-312840-jvdph782 198 44 in in IN cord-312840-jvdph782 198 45 japan japan NNP cord-312840-jvdph782 199 1 Different different JJ cord-312840-jvdph782 199 2 epidemic epidemic NN cord-312840-jvdph782 199 3 curves curve NNS cord-312840-jvdph782 199 4 for for IN cord-312840-jvdph782 199 5 severe severe JJ cord-312840-jvdph782 199 6 acute acute JJ cord-312840-jvdph782 199 7 respiratory respiratory JJ cord-312840-jvdph782 199 8 syndrome syndrome NN cord-312840-jvdph782 199 9 reveal reveal VBP cord-312840-jvdph782 199 10 similar similar JJ cord-312840-jvdph782 199 11 impacts impact NNS cord-312840-jvdph782 199 12 of of IN cord-312840-jvdph782 199 13 control control NN cord-312840-jvdph782 199 14 measures measure NNS cord-312840-jvdph782 199 15 Interim interim JJ cord-312840-jvdph782 199 16 report report NN cord-312840-jvdph782 199 17 on on IN cord-312840-jvdph782 199 18 pandemic pandemic JJ cord-312840-jvdph782 199 19 H1N1 H1N1 NNP cord-312840-jvdph782 199 20 influenza influenza NN cord-312840-jvdph782 199 21 virus virus NN cord-312840-jvdph782 199 22 infections infection NNS cord-312840-jvdph782 199 23 in in IN cord-312840-jvdph782 199 24 South South NNP cord-312840-jvdph782 199 25 Africa Africa NNP cord-312840-jvdph782 199 26 epidemiology epidemiology NN cord-312840-jvdph782 199 27 and and CC cord-312840-jvdph782 199 28 factors factor NNS cord-312840-jvdph782 199 29 associated associate VBN cord-312840-jvdph782 199 30 with with IN cord-312840-jvdph782 199 31 fatal fatal JJ cord-312840-jvdph782 199 32 cases case NNS cord-312840-jvdph782 200 1 Reproductive reproductive JJ cord-312840-jvdph782 200 2 number number NN cord-312840-jvdph782 200 3 and and CC cord-312840-jvdph782 200 4 serial serial JJ cord-312840-jvdph782 200 5 interval interval NN cord-312840-jvdph782 200 6 of of IN cord-312840-jvdph782 200 7 the the DT cord-312840-jvdph782 200 8 first first JJ cord-312840-jvdph782 200 9 wave wave NN cord-312840-jvdph782 200 10 of of IN cord-312840-jvdph782 200 11 influenza influenza NN cord-312840-jvdph782 200 12 A a NN cord-312840-jvdph782 200 13 ( ( -LRB- cord-312840-jvdph782 200 14 H1N1 H1N1 NNP cord-312840-jvdph782 200 15 ) ) -RRB- cord-312840-jvdph782 200 16 pdm09 pdm09 , cord-312840-jvdph782 200 17 virus virus NN cord-312840-jvdph782 200 18 in in IN cord-312840-jvdph782 200 19 South South NNP cord-312840-jvdph782 200 20 Africa Africa NNP cord-312840-jvdph782 200 21 Using use VBG cord-312840-jvdph782 200 22 an an DT cord-312840-jvdph782 200 23 online online JJ cord-312840-jvdph782 200 24 survey survey NN cord-312840-jvdph782 200 25 of of IN cord-312840-jvdph782 200 26 healthcare healthcare NN cord-312840-jvdph782 200 27 - - HYPH cord-312840-jvdph782 200 28 seeking seek VBG cord-312840-jvdph782 200 29 behaviour behaviour NN cord-312840-jvdph782 200 30 to to TO cord-312840-jvdph782 200 31 estimate estimate VB cord-312840-jvdph782 200 32 the the DT cord-312840-jvdph782 200 33 magnitude magnitude NN cord-312840-jvdph782 200 34 and and CC cord-312840-jvdph782 200 35 severity severity NN cord-312840-jvdph782 200 36 of of IN cord-312840-jvdph782 200 37 the the DT cord-312840-jvdph782 200 38 2009 2009 CD cord-312840-jvdph782 200 39 H1N1v H1N1v NNP cord-312840-jvdph782 201 1 influenza influenza JJ cord-312840-jvdph782 201 2 epidemic epidemic NN cord-312840-jvdph782 201 3 in in IN cord-312840-jvdph782 201 4 England England NNP cord-312840-jvdph782 201 5 Estimating estimate VBG cord-312840-jvdph782 201 6 the the DT cord-312840-jvdph782 201 7 reproductive reproductive JJ cord-312840-jvdph782 201 8 number number NN cord-312840-jvdph782 201 9 in in IN cord-312840-jvdph782 201 10 the the DT cord-312840-jvdph782 201 11 presence presence NN cord-312840-jvdph782 201 12 of of IN cord-312840-jvdph782 201 13 spatial spatial JJ cord-312840-jvdph782 201 14 heterogeneity heterogeneity NN cord-312840-jvdph782 201 15 of of IN cord-312840-jvdph782 201 16 transmission transmission NN cord-312840-jvdph782 201 17 patterns pattern NNS cord-312840-jvdph782 202 1 The the DT cord-312840-jvdph782 202 2 impact impact NN cord-312840-jvdph782 202 3 of of IN cord-312840-jvdph782 202 4 illness illness NN cord-312840-jvdph782 202 5 and and CC cord-312840-jvdph782 202 6 the the DT cord-312840-jvdph782 202 7 impact impact NN cord-312840-jvdph782 202 8 of of IN cord-312840-jvdph782 202 9 school school NN cord-312840-jvdph782 202 10 closure closure NN cord-312840-jvdph782 202 11 on on IN cord-312840-jvdph782 202 12 social social JJ cord-312840-jvdph782 202 13 contact contact NN cord-312840-jvdph782 202 14 patterns pattern NNS cord-312840-jvdph782 203 1 The the DT cord-312840-jvdph782 203 2 impact impact NN cord-312840-jvdph782 203 3 of of IN cord-312840-jvdph782 203 4 illness illness NN cord-312840-jvdph782 203 5 on on IN cord-312840-jvdph782 203 6 social social JJ cord-312840-jvdph782 203 7 networks network NNS cord-312840-jvdph782 203 8 : : : cord-312840-jvdph782 203 9 Implications implication NNS cord-312840-jvdph782 203 10 for for IN cord-312840-jvdph782 203 11 transmission transmission NN cord-312840-jvdph782 203 12 and and CC cord-312840-jvdph782 203 13 control control NN cord-312840-jvdph782 203 14 of of IN cord-312840-jvdph782 203 15 influenza influenza NN cord-312840-jvdph782 203 16 Reporting reporting NN cord-312840-jvdph782 203 17 errors error NNS cord-312840-jvdph782 203 18 in in IN cord-312840-jvdph782 203 19 infectious infectious JJ cord-312840-jvdph782 203 20 disease disease NN cord-312840-jvdph782 203 21 outbreaks outbreak NNS cord-312840-jvdph782 203 22 , , , cord-312840-jvdph782 203 23 with with IN cord-312840-jvdph782 203 24 an an DT cord-312840-jvdph782 203 25 application application NN cord-312840-jvdph782 203 26 to to IN cord-312840-jvdph782 203 27 pandemic pandemic NN cord-312840-jvdph782 203 28 influenza influenza NN cord-312840-jvdph782 203 29 A A NNP cord-312840-jvdph782 203 30 / / SYM cord-312840-jvdph782 203 31 H1N1 H1N1 NNP cord-312840-jvdph782 203 32 Estimates Estimates NNPS cord-312840-jvdph782 203 33 of of IN cord-312840-jvdph782 203 34 the the DT cord-312840-jvdph782 203 35 prevalence prevalence NN cord-312840-jvdph782 203 36 of of IN cord-312840-jvdph782 203 37 pandemic pandemic NN cord-312840-jvdph782 203 38 ( ( -LRB- cord-312840-jvdph782 203 39 H1N1 H1N1 NNP cord-312840-jvdph782 203 40 ) ) -RRB- cord-312840-jvdph782 203 41 2009 2009 CD cord-312840-jvdph782 203 42 , , , cord-312840-jvdph782 203 43 United United NNP cord-312840-jvdph782 203 44 States States NNP cord-312840-jvdph782 203 45 Food Food NNP cord-312840-jvdph782 203 46 - - HYPH cord-312840-jvdph782 203 47 related relate VBN cord-312840-jvdph782 203 48 illness illness NN cord-312840-jvdph782 203 49 and and CC cord-312840-jvdph782 203 50 death death NN cord-312840-jvdph782 203 51 in in IN cord-312840-jvdph782 203 52 the the DT cord-312840-jvdph782 203 53 United United NNP cord-312840-jvdph782 203 54 States States NNP cord-312840-jvdph782 203 55 Estimating Estimating NNP cord-312840-jvdph782 203 56 in in IN cord-312840-jvdph782 203 57 real real JJ cord-312840-jvdph782 203 58 time time NN cord-312840-jvdph782 203 59 the the DT cord-312840-jvdph782 203 60 efficacy efficacy NN cord-312840-jvdph782 203 61 of of IN cord-312840-jvdph782 203 62 measures measure NNS cord-312840-jvdph782 203 63 to to TO cord-312840-jvdph782 203 64 control control VB cord-312840-jvdph782 203 65 emerging emerge VBG cord-312840-jvdph782 203 66 communicable communicable JJ cord-312840-jvdph782 203 67 diseases disease NNS cord-312840-jvdph782 203 68 Determining determine VBG cord-312840-jvdph782 203 69 the the DT cord-312840-jvdph782 203 70 dynamics dynamic NNS cord-312840-jvdph782 203 71 of of IN cord-312840-jvdph782 203 72 influenza influenza NN cord-312840-jvdph782 203 73 transmission transmission NN cord-312840-jvdph782 203 74 by by IN cord-312840-jvdph782 203 75 age age NN cord-312840-jvdph782 204 1 The the DT cord-312840-jvdph782 204 2 project project NN cord-312840-jvdph782 204 3 described describe VBN cord-312840-jvdph782 204 4 was be VBD cord-312840-jvdph782 204 5 supported support VBN cord-312840-jvdph782 204 6 by by IN cord-312840-jvdph782 204 7 Award Award NNP cord-312840-jvdph782 204 8 Number Number NNP cord-312840-jvdph782 204 9 U54GM088558 U54GM088558 NNP cord-312840-jvdph782 204 10 from from IN cord-312840-jvdph782 204 11 the the DT cord-312840-jvdph782 204 12 National National NNP cord-312840-jvdph782 204 13 Institute Institute NNP cord-312840-jvdph782 204 14 of of IN cord-312840-jvdph782 204 15 General General NNP cord-312840-jvdph782 204 16 Medical Medical NNP cord-312840-jvdph782 204 17 Sciences Sciences NNPS cord-312840-jvdph782 204 18 to to IN cord-312840-jvdph782 204 19 L.F.W. L.F.W. NNP cord-312840-jvdph782 204 20 and and CC cord-312840-jvdph782 205 1 M.P. M.P. NNP cord-312840-jvdph782 205 2 The the DT cord-312840-jvdph782 205 3 content content NN cord-312840-jvdph782 205 4 is be VBZ cord-312840-jvdph782 205 5 solely solely RB cord-312840-jvdph782 205 6 the the DT cord-312840-jvdph782 205 7 responsibility responsibility NN cord-312840-jvdph782 205 8 of of IN cord-312840-jvdph782 205 9 the the DT cord-312840-jvdph782 205 10 authors author NNS cord-312840-jvdph782 205 11 and and CC cord-312840-jvdph782 205 12 does do VBZ cord-312840-jvdph782 205 13 not not RB cord-312840-jvdph782 205 14 necessarily necessarily RB cord-312840-jvdph782 205 15 represent represent VB cord-312840-jvdph782 205 16 the the DT cord-312840-jvdph782 205 17 official official JJ cord-312840-jvdph782 205 18 views view NNS cord-312840-jvdph782 205 19 of of IN cord-312840-jvdph782 205 20 the the DT cord-312840-jvdph782 205 21 National National NNP cord-312840-jvdph782 205 22 Institute Institute NNP cord-312840-jvdph782 205 23 of of IN cord-312840-jvdph782 205 24 General General NNP cord-312840-jvdph782 205 25 Medical Medical NNP cord-312840-jvdph782 205 26 Sciences Sciences NNPS cord-312840-jvdph782 205 27 or or CC cord-312840-jvdph782 205 28 the the DT cord-312840-jvdph782 205 29 National National NNP cord-312840-jvdph782 205 30 Institutes Institutes NNPS cord-312840-jvdph782 205 31 of of IN cord-312840-jvdph782 205 32 Health Health NNP cord-312840-jvdph782 205 33 . . . cord-312840-jvdph782 206 1 Sensitivity sensitivity NN cord-312840-jvdph782 206 2 analysis analysis NN cord-312840-jvdph782 206 3 : : : cord-312840-jvdph782 206 4 Impact impact NN cord-312840-jvdph782 206 5 of of IN cord-312840-jvdph782 206 6 differential differential JJ cord-312840-jvdph782 206 7 reporting reporting NN cord-312840-jvdph782 206 8 by by IN cord-312840-jvdph782 206 9 ageWe ageWe NNS cord-312840-jvdph782 206 10 assume assume VBP cord-312840-jvdph782 206 11 that that IN cord-312840-jvdph782 206 12 the the DT cord-312840-jvdph782 206 13 reporting reporting NN cord-312840-jvdph782 206 14 distribution distribution NN cord-312840-jvdph782 206 15 by by IN cord-312840-jvdph782 206 16 age age NN cord-312840-jvdph782 206 17 follows follow VBZ cord-312840-jvdph782 206 18 a a DT cord-312840-jvdph782 206 19 U u NN cord-312840-jvdph782 206 20 - - HYPH cord-312840-jvdph782 206 21 shaped shape VBN cord-312840-jvdph782 206 22 distribution distribution NN cord-312840-jvdph782 206 23 , , , cord-312840-jvdph782 206 24 implying imply VBG cord-312840-jvdph782 206 25 that that IN cord-312840-jvdph782 206 26 the the DT cord-312840-jvdph782 206 27 very very RB cord-312840-jvdph782 206 28 young young JJ cord-312840-jvdph782 206 29 and and CC cord-312840-jvdph782 206 30 very very RB cord-312840-jvdph782 206 31 old old JJ cord-312840-jvdph782 206 32 are be VBP cord-312840-jvdph782 206 33 most most RBS cord-312840-jvdph782 206 34 likely likely JJ cord-312840-jvdph782 206 35 to to TO cord-312840-jvdph782 206 36 seek seek VB cord-312840-jvdph782 206 37 healthcare healthcare NN cord-312840-jvdph782 206 38 and and CC cord-312840-jvdph782 206 39 have have VBP cord-312840-jvdph782 206 40 their -PRON- PRP$ cord-312840-jvdph782 206 41 cases case NNS cord-312840-jvdph782 206 42 reported report VBN cord-312840-jvdph782 206 43 . . . cord-312840-jvdph782 207 1 To to TO cord-312840-jvdph782 207 2 obtain obtain VB cord-312840-jvdph782 207 3 a a DT cord-312840-jvdph782 207 4 distribution distribution NN cord-312840-jvdph782 207 5 that that WDT cord-312840-jvdph782 207 6 follows follow VBZ cord-312840-jvdph782 207 7 this this DT cord-312840-jvdph782 207 8 shape shape NN cord-312840-jvdph782 207 9 , , , cord-312840-jvdph782 207 10 we -PRON- PRP cord-312840-jvdph782 207 11 use use VBP cord-312840-jvdph782 207 12 the the DT cord-312840-jvdph782 207 13 distribution distribution NN cord-312840-jvdph782 207 14 of of IN cord-312840-jvdph782 207 15 hospitalized hospitalize VBN cord-312840-jvdph782 207 16 cases case NNS cord-312840-jvdph782 207 17 by by IN cord-312840-jvdph782 207 18 age age NN cord-312840-jvdph782 207 19 in in IN cord-312840-jvdph782 207 20 our -PRON- PRP$ cord-312840-jvdph782 207 21 data datum NNS cord-312840-jvdph782 207 22 , , , cord-312840-jvdph782 207 23 rescale rescale VB cord-312840-jvdph782 207 24 it -PRON- PRP cord-312840-jvdph782 207 25 so so IN cord-312840-jvdph782 207 26 that that IN cord-312840-jvdph782 207 27 the the DT cord-312840-jvdph782 207 28 highest high JJS cord-312840-jvdph782 207 29 proportion proportion NN cord-312840-jvdph782 207 30 is be VBZ cord-312840-jvdph782 207 31 one one CD cord-312840-jvdph782 207 32 , , , cord-312840-jvdph782 207 33 and and CC cord-312840-jvdph782 207 34 smooth smooth VB cord-312840-jvdph782 207 35 the the DT cord-312840-jvdph782 207 36 distribution distribution NN cord-312840-jvdph782 207 37 using use VBG cord-312840-jvdph782 207 38 a a DT cord-312840-jvdph782 207 39 loess loess NN cord-312840-jvdph782 207 40 smoother smoother RBR cord-312840-jvdph782 207 41 ( ( -LRB- cord-312840-jvdph782 207 42 Additional additional JJ cord-312840-jvdph782 207 43 file file NN cord-312840-jvdph782 207 44 3 3 CD cord-312840-jvdph782 207 45 : : : cord-312840-jvdph782 207 46 Figure figure NN cord-312840-jvdph782 207 47 S1 S1 NNP cord-312840-jvdph782 207 48 ) ) -RRB- cord-312840-jvdph782 207 49 .We .We . cord-312840-jvdph782 208 1 use use VBP cord-312840-jvdph782 208 2 25 25 CD cord-312840-jvdph782 208 3 of of IN cord-312840-jvdph782 208 4 our -PRON- PRP$ cord-312840-jvdph782 208 5 imputed imputed JJ cord-312840-jvdph782 208 6 datasets dataset NNS cord-312840-jvdph782 208 7 and and CC cord-312840-jvdph782 208 8 augment augment VB cord-312840-jvdph782 208 9 each each DT cord-312840-jvdph782 208 10 dataset dataset NN cord-312840-jvdph782 208 11 using use VBG cord-312840-jvdph782 208 12 the the DT cord-312840-jvdph782 208 13 distribution distribution NN cord-312840-jvdph782 208 14 f f NN cord-312840-jvdph782 208 15 ( ( -LRB- cord-312840-jvdph782 208 16 x x NNP cord-312840-jvdph782 208 17 ) ) -RRB- cord-312840-jvdph782 208 18 , , , cord-312840-jvdph782 208 19 where where WRB cord-312840-jvdph782 208 20 f f NNP cord-312840-jvdph782 208 21 ( ( -LRB- cord-312840-jvdph782 208 22 x x NNP cord-312840-jvdph782 208 23 ) ) -RRB- cord-312840-jvdph782 208 24 is be VBZ cord-312840-jvdph782 208 25 a a DT cord-312840-jvdph782 208 26 function function NN cord-312840-jvdph782 208 27 of of IN cord-312840-jvdph782 208 28 the the DT cord-312840-jvdph782 208 29 original original JJ cord-312840-jvdph782 208 30 age age NN cord-312840-jvdph782 208 31 distribution distribution NN cord-312840-jvdph782 208 32 observed observe VBN cord-312840-jvdph782 208 33 in in IN cord-312840-jvdph782 208 34 the the DT cord-312840-jvdph782 208 35 data datum NNS cord-312840-jvdph782 208 36 , , , cord-312840-jvdph782 208 37 g g NNP cord-312840-jvdph782 208 38 ( ( -LRB- cord-312840-jvdph782 208 39 x x NNP cord-312840-jvdph782 208 40 ) ) -RRB- cord-312840-jvdph782 208 41 , , , cord-312840-jvdph782 208 42 and and CC cord-312840-jvdph782 208 43 the the DT cord-312840-jvdph782 208 44 reporting reporting NN cord-312840-jvdph782 208 45 distribution distribution NN cord-312840-jvdph782 208 46 shown show VBN cord-312840-jvdph782 208 47 in in IN cord-312840-jvdph782 208 48 Additional additional JJ cord-312840-jvdph782 208 49 file file NN cord-312840-jvdph782 208 50 3 3 CD cord-312840-jvdph782 208 51 : : : cord-312840-jvdph782 208 52 Figure figure NN cord-312840-jvdph782 208 53 S1 s1 NN cord-312840-jvdph782 208 54 , , , cord-312840-jvdph782 208 55 h h NNP cord-312840-jvdph782 208 56 ( ( -LRB- cord-312840-jvdph782 208 57 x x NNP cord-312840-jvdph782 208 58 ) ) -RRB- cord-312840-jvdph782 208 59 , , , cord-312840-jvdph782 208 60 as as IN cord-312840-jvdph782 208 61 follows follow VBZ cord-312840-jvdph782 208 62 : : : cord-312840-jvdph782 208 63 Here here RB cord-312840-jvdph782 208 64 λ λ NN cord-312840-jvdph782 208 65 ranges range VBZ cord-312840-jvdph782 208 66 between between IN cord-312840-jvdph782 208 67 0 0 CD cord-312840-jvdph782 208 68 and and CC cord-312840-jvdph782 208 69 1 1 CD cord-312840-jvdph782 208 70 . . . cord-312840-jvdph782 209 1 We -PRON- PRP cord-312840-jvdph782 209 2 run run VBP cord-312840-jvdph782 209 3 analyses analysis NNS cord-312840-jvdph782 209 4 for for IN cord-312840-jvdph782 209 5 λ λ NN cord-312840-jvdph782 209 6 = = SYM cord-312840-jvdph782 209 7 0.0 0.0 CD cord-312840-jvdph782 209 8 , , , cord-312840-jvdph782 209 9 0.25 0.25 CD cord-312840-jvdph782 209 10 , , , cord-312840-jvdph782 209 11 0.50 0.50 CD cord-312840-jvdph782 209 12 , , , cord-312840-jvdph782 209 13 0.75 0.75 CD cord-312840-jvdph782 209 14 and and CC cord-312840-jvdph782 209 15 1.0 1.0 CD cord-312840-jvdph782 209 16 ( ( -LRB- cord-312840-jvdph782 209 17 corresponding correspond VBG cord-312840-jvdph782 209 18 to to IN cord-312840-jvdph782 209 19 the the DT cord-312840-jvdph782 209 20 original original JJ cord-312840-jvdph782 209 21 analysis analysis NN cord-312840-jvdph782 209 22 ) ) -RRB- cord-312840-jvdph782 209 23 . . . cord-312840-jvdph782 210 1 Results result NNS cord-312840-jvdph782 210 2 for for IN cord-312840-jvdph782 210 3 all all DT cord-312840-jvdph782 210 4 25 25 CD cord-312840-jvdph782 210 5 datasets dataset NNS cord-312840-jvdph782 210 6 are be VBP cord-312840-jvdph782 210 7 shown show VBN cord-312840-jvdph782 210 8 in in IN cord-312840-jvdph782 210 9 Additional additional JJ cord-312840-jvdph782 210 10 file file NN cord-312840-jvdph782 210 11 2 2 CD cord-312840-jvdph782 210 12 : : : cord-312840-jvdph782 210 13 Table table NN cord-312840-jvdph782 210 14 S2 s2 NN cord-312840-jvdph782 210 15 . . . cord-312840-jvdph782 211 1 Additional additional JJ cord-312840-jvdph782 211 2 file file NN cord-312840-jvdph782 211 3 1 1 CD cord-312840-jvdph782 211 4 : : : cord-312840-jvdph782 211 5 Table table NN cord-312840-jvdph782 211 6 S1 S1 NNP cord-312840-jvdph782 211 7 . . . cord-312840-jvdph782 212 1 Results result NNS cord-312840-jvdph782 212 2 for for IN cord-312840-jvdph782 212 3 the the DT cord-312840-jvdph782 212 4 sensitivity sensitivity NN cord-312840-jvdph782 212 5 analysis analysis NN cord-312840-jvdph782 212 6 using use VBG cord-312840-jvdph782 212 7 the the DT cord-312840-jvdph782 212 8 South South NNP cord-312840-jvdph782 212 9 African african JJ cord-312840-jvdph782 212 10 based base VBN cord-312840-jvdph782 212 11 age age NN cord-312840-jvdph782 212 12 contact contact NN cord-312840-jvdph782 212 13 information information NN cord-312840-jvdph782 212 14 . . . cord-312840-jvdph782 213 1 Result result NN cord-312840-jvdph782 213 2 presented present VBN cord-312840-jvdph782 213 3 is be VBZ cord-312840-jvdph782 213 4 the the DT cord-312840-jvdph782 213 5 estimate estimate NN cord-312840-jvdph782 213 6 obtained obtain VBN cord-312840-jvdph782 213 7 from from IN cord-312840-jvdph782 213 8 the the DT cord-312840-jvdph782 213 9 original original JJ cord-312840-jvdph782 213 10 dataset dataset NN cord-312840-jvdph782 213 11 and and CC cord-312840-jvdph782 213 12 the the DT cord-312840-jvdph782 213 13 values value NNS cord-312840-jvdph782 213 14 in in IN cord-312840-jvdph782 213 15 the the DT cord-312840-jvdph782 213 16 parentheses parenthesis NNS cord-312840-jvdph782 213 17 represent represent VBP cord-312840-jvdph782 213 18 the the DT cord-312840-jvdph782 213 19 range range NN cord-312840-jvdph782 213 20 of of IN cord-312840-jvdph782 213 21 values value NNS cord-312840-jvdph782 213 22 obtained obtain VBN cord-312840-jvdph782 213 23 over over IN cord-312840-jvdph782 213 24 the the DT cord-312840-jvdph782 213 25 50 50 CD cord-312840-jvdph782 213 26 datasets dataset NNS cord-312840-jvdph782 213 27 generated generate VBN cord-312840-jvdph782 213 28 for for IN cord-312840-jvdph782 213 29 the the DT cord-312840-jvdph782 213 30 sensitivity sensitivity NN cord-312840-jvdph782 213 31 analysis analysis NN cord-312840-jvdph782 213 32 . . . cord-312840-jvdph782 214 1 Additional additional JJ cord-312840-jvdph782 214 2 file file NN cord-312840-jvdph782 214 3 2 2 CD cord-312840-jvdph782 214 4 : : : cord-312840-jvdph782 214 5 Table table NN cord-312840-jvdph782 214 6 S2 s2 NN cord-312840-jvdph782 214 7 . . . cord-312840-jvdph782 215 1 Estimates estimate NNS cord-312840-jvdph782 215 2 of of IN cord-312840-jvdph782 215 3 R r NN cord-312840-jvdph782 215 4 0 0 CD cord-312840-jvdph782 215 5 using use VBG cord-312840-jvdph782 215 6 25 25 CD cord-312840-jvdph782 215 7 of of IN cord-312840-jvdph782 215 8 the the DT cord-312840-jvdph782 215 9 500 500 CD cord-312840-jvdph782 215 10 imputations imputation NNS cord-312840-jvdph782 215 11 described describe VBN cord-312840-jvdph782 215 12 in in IN cord-312840-jvdph782 215 13 the the DT cord-312840-jvdph782 215 14 original original JJ cord-312840-jvdph782 215 15 text text NN cord-312840-jvdph782 215 16 . . . cord-312840-jvdph782 216 1 Results result NNS cord-312840-jvdph782 216 2 shown show VBN cord-312840-jvdph782 216 3 are be VBP cord-312840-jvdph782 216 4 the the DT cord-312840-jvdph782 216 5 mean mean JJ cord-312840-jvdph782 216 6 and and CC cord-312840-jvdph782 216 7 range range NN cord-312840-jvdph782 216 8 of of IN cord-312840-jvdph782 216 9 estimates estimate NNS cord-312840-jvdph782 216 10 across across IN cord-312840-jvdph782 216 11 the the DT cord-312840-jvdph782 216 12 25 25 CD cord-312840-jvdph782 216 13 imputed impute VBN cord-312840-jvdph782 216 14 datasets dataset NNS cord-312840-jvdph782 216 15 . . . cord-312840-jvdph782 217 1 λ=1.00 λ=1.00 NN cord-312840-jvdph782 217 2 corresponds correspond VBZ cord-312840-jvdph782 217 3 to to IN cord-312840-jvdph782 217 4 the the DT cord-312840-jvdph782 217 5 results result NNS cord-312840-jvdph782 217 6 from from IN cord-312840-jvdph782 217 7 the the DT cord-312840-jvdph782 217 8 original original JJ cord-312840-jvdph782 217 9 analysis analysis NN cord-312840-jvdph782 217 10 . . . cord-312840-jvdph782 218 1 Additional additional JJ cord-312840-jvdph782 218 2 file file NN cord-312840-jvdph782 218 3 3 3 CD cord-312840-jvdph782 218 4 : : : cord-312840-jvdph782 218 5 Figure figure VB cord-312840-jvdph782 218 6 S1 s1 NN cord-312840-jvdph782 218 7 . . . cord-312840-jvdph782 219 1 Smoothed smooth VBN cord-312840-jvdph782 219 2 distribution distribution NN cord-312840-jvdph782 219 3 to to TO cord-312840-jvdph782 219 4 reflect reflect VB cord-312840-jvdph782 219 5 potential potential JJ cord-312840-jvdph782 219 6 rates rate NNS cord-312840-jvdph782 219 7 of of IN cord-312840-jvdph782 219 8 healthcare healthcare NN cord-312840-jvdph782 219 9 seeking seek VBG cord-312840-jvdph782 219 10 behavior behavior NN cord-312840-jvdph782 219 11 and/or and/or CC cord-312840-jvdph782 219 12 case case NN cord-312840-jvdph782 219 13 - - HYPH cord-312840-jvdph782 219 14 reporting reporting NN cord-312840-jvdph782 219 15 by by IN cord-312840-jvdph782 219 16 age age NN cord-312840-jvdph782 219 17 . . . cord-312840-jvdph782 220 1 The the DT cord-312840-jvdph782 220 2 authors author NNS cord-312840-jvdph782 220 3 report report VBP cord-312840-jvdph782 220 4 no no DT cord-312840-jvdph782 220 5 conflicts conflict NNS cord-312840-jvdph782 220 6 of of IN cord-312840-jvdph782 220 7 interest interest NN cord-312840-jvdph782 220 8 . . . cord-312840-jvdph782 220 9 _SP