id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005845-axrv8zfg	O'Brien, Stephen J.	Genomic prospecting	1995		.txt	text/plain	2358	123	40	When cheetahs became exposed recently to feline infectious peritonitis virus, a coronavirus with low morbidity and mortality in domestic cats (about 1 per cent affected), 100 per cent of infected cheetahs developed symptoms (diarrhea, jaundice, depression, fever) and 60 per cent died 7 • The cheetah's homogeneous sensitivity to this agent in the face of genetic monomorphism at the MHC provided a rationale for the critical importance of MHC genetic variation in natural populations. Some fascinating insight about lethal infectious disease and natural genetic defences appeared from a wild mouse population in a squab farm near Lake Casitas, forty miles north of Los Angeles' 0 • Murray Gardner (University of California at Davis) discovered that the mice were suffering a raging epidemic with a retrovirus that caused fatal hindlimb paralysis. Finally, with the recent development of high resolution comparative gene maps of primate, cat, and other mammalian species, the genetic basis of lentivirus resistance can now be approached'".	./cache/cord-005845-axrv8zfg.txt	./txt/cord-005845-axrv8zfg.txt