id sid tid token lemma pos cord-352796-6einbent 1 1 key key JJ cord-352796-6einbent 1 2 : : : cord-352796-6einbent 1 3 cord-352796 cord-352796 NNP cord-352796-6einbent 1 4 - - HYPH cord-352796-6einbent 1 5 6einbent 6einbent CD cord-352796-6einbent 1 6 authors author NNS cord-352796-6einbent 1 7 : : : cord-352796-6einbent 2 1 Theodore Theodore NNP cord-352796-6einbent 2 2 Coroneo Coroneo NNP cord-352796-6einbent 2 3 , , , cord-352796-6einbent 2 4 Minas Minas NNP cord-352796-6einbent 2 5 title title NN cord-352796-6einbent 2 6 : : : cord-352796-6einbent 2 7 The the DT cord-352796-6einbent 2 8 eye eye NN cord-352796-6einbent 2 9 as as IN cord-352796-6einbent 2 10 the the DT cord-352796-6einbent 2 11 discrete discrete JJ cord-352796-6einbent 2 12 but but CC cord-352796-6einbent 2 13 defensible defensible JJ cord-352796-6einbent 2 14 portal portal NN cord-352796-6einbent 2 15 of of IN cord-352796-6einbent 2 16 coronavirus coronavirus NN cord-352796-6einbent 2 17 infection infection NN cord-352796-6einbent 2 18 date date NN cord-352796-6einbent 2 19 : : : cord-352796-6einbent 2 20 2020 2020 CD cord-352796-6einbent 2 21 - - HYPH cord-352796-6einbent 2 22 05 05 CD cord-352796-6einbent 2 23 - - SYM cord-352796-6einbent 2 24 21 21 CD cord-352796-6einbent 2 25 journal journal NN cord-352796-6einbent 2 26 : : : cord-352796-6einbent 2 27 Ocul Ocul NNP cord-352796-6einbent 2 28 Surf Surf NNP cord-352796-6einbent 2 29 DOI DOI NNP cord-352796-6einbent 2 30 : : : cord-352796-6einbent 2 31 10.1016 10.1016 CD cord-352796-6einbent 2 32 / / SYM cord-352796-6einbent 2 33 j.jtos.2020.05.011 j.jtos.2020.05.011 CD cord-352796-6einbent 2 34 sha sha NNP cord-352796-6einbent 2 35 : : : cord-352796-6einbent 2 36 b818cfa6c8e17745679095305899f5e67cfd4323 b818cfa6c8e17745679095305899f5e67cfd4323 NNP cord-352796-6einbent 2 37 doc_id doc_id CD cord-352796-6einbent 2 38 : : : cord-352796-6einbent 2 39 352796 352796 CD cord-352796-6einbent 2 40 cord_uid cord_uid NNS cord-352796-6einbent 2 41 : : : cord-352796-6einbent 2 42 6einbent 6einbent CD cord-352796-6einbent 2 43 Oculo Oculo NNP cord-352796-6einbent 2 44 - - HYPH cord-352796-6einbent 2 45 centric centric NN cord-352796-6einbent 2 46 factors factor NNS cord-352796-6einbent 2 47 may may MD cord-352796-6einbent 2 48 provide provide VB cord-352796-6einbent 2 49 a a DT cord-352796-6einbent 2 50 key key NN cord-352796-6einbent 2 51 to to IN cord-352796-6einbent 2 52 understanding understand VBG cord-352796-6einbent 2 53 invasion invasion NN cord-352796-6einbent 2 54 success success NN cord-352796-6einbent 2 55 by by IN cord-352796-6einbent 2 56 SARS SARS NNP cord-352796-6einbent 2 57 - - HYPH cord-352796-6einbent 2 58 CoV-2 CoV-2 NNP cord-352796-6einbent 2 59 , , , cord-352796-6einbent 2 60 a a DT cord-352796-6einbent 2 61 highly highly RB cord-352796-6einbent 2 62 contagious contagious JJ cord-352796-6einbent 2 63 , , , cord-352796-6einbent 2 64 potentially potentially RB cord-352796-6einbent 2 65 lethal lethal JJ cord-352796-6einbent 2 66 , , , cord-352796-6einbent 2 67 virus virus NN cord-352796-6einbent 2 68 with with IN cord-352796-6einbent 2 69 ocular ocular JJ cord-352796-6einbent 2 70 tropism tropism NN cord-352796-6einbent 2 71 . . . cord-352796-6einbent 3 1 Respiratory respiratory JJ cord-352796-6einbent 3 2 infection infection NN cord-352796-6einbent 3 3 transmission transmission NN cord-352796-6einbent 3 4 via via IN cord-352796-6einbent 3 5 the the DT cord-352796-6einbent 3 6 eye eye NN cord-352796-6einbent 3 7 and and CC cord-352796-6einbent 3 8 lacrimal lacrimal NN cord-352796-6einbent 3 9 - - HYPH cord-352796-6einbent 3 10 nasal nasal NN cord-352796-6einbent 3 11 pathway pathway NN cord-352796-6einbent 3 12 elucidated elucidate VBN cord-352796-6einbent 3 13 during during IN cord-352796-6einbent 3 14 the the DT cord-352796-6einbent 3 15 1918 1918 CD cord-352796-6einbent 3 16 influenza influenza NN cord-352796-6einbent 3 17 pandemic pandemic NN cord-352796-6einbent 3 18 , , , cord-352796-6einbent 3 19 remains remain VBZ cord-352796-6einbent 3 20 to to TO cord-352796-6einbent 3 21 be be VB cord-352796-6einbent 3 22 explored explore VBN cord-352796-6einbent 3 23 in in IN cord-352796-6einbent 3 24 this this DT cord-352796-6einbent 3 25 crisis crisis NN cord-352796-6einbent 3 26 . . . cord-352796-6einbent 4 1 The the DT cord-352796-6einbent 4 2 eye eye NN cord-352796-6einbent 4 3 and and CC cord-352796-6einbent 4 4 its -PRON- PRP$ cord-352796-6einbent 4 5 adnexae adnexae NN cord-352796-6einbent 4 6 represent represent VBP cord-352796-6einbent 4 7 a a DT cord-352796-6einbent 4 8 large large JJ cord-352796-6einbent 4 9 surface surface NN cord-352796-6einbent 4 10 area area NN cord-352796-6einbent 4 11 directly directly RB cord-352796-6einbent 4 12 exposed expose VBN cord-352796-6einbent 4 13 to to IN cord-352796-6einbent 4 14 airborne airborne JJ cord-352796-6einbent 4 15 viral viral JJ cord-352796-6einbent 4 16 particles particle NNS cord-352796-6einbent 4 17 and and CC cord-352796-6einbent 4 18 hand hand NN cord-352796-6einbent 4 19 contact contact NN cord-352796-6einbent 4 20 . . . cord-352796-6einbent 5 1 The the DT cord-352796-6einbent 5 2 virus virus NN cord-352796-6einbent 5 3 may may MD cord-352796-6einbent 5 4 bind bind VB cord-352796-6einbent 5 5 to to IN cord-352796-6einbent 5 6 corneal corneal JJ cord-352796-6einbent 5 7 and and CC cord-352796-6einbent 5 8 conjunctival conjunctival JJ cord-352796-6einbent 5 9 angiotensin angiotensin NN cord-352796-6einbent 5 10 converting convert VBG cord-352796-6einbent 5 11 enzyme enzyme NN cord-352796-6einbent 5 12 2 2 CD cord-352796-6einbent 6 1 ( ( -LRB- cord-352796-6einbent 6 2 ACE2 ACE2 NNP cord-352796-6einbent 6 3 ) ) -RRB- cord-352796-6einbent 6 4 receptors receptor NNS cord-352796-6einbent 6 5 and and CC cord-352796-6einbent 6 6 potentially potentially RB cord-352796-6einbent 6 7 to to IN cord-352796-6einbent 6 8 the the DT cord-352796-6einbent 6 9 lipophilic lipophilic JJ cord-352796-6einbent 6 10 periocular periocular NN cord-352796-6einbent 6 11 skin skin NN cord-352796-6einbent 6 12 and and CC cord-352796-6einbent 6 13 superficial superficial JJ cord-352796-6einbent 6 14 tear tear JJ cord-352796-6einbent 6 15 film film NN cord-352796-6einbent 6 16 with with IN cord-352796-6einbent 6 17 downstream downstream JJ cord-352796-6einbent 6 18 carriage carriage NN cord-352796-6einbent 6 19 into into IN cord-352796-6einbent 6 20 the the DT cord-352796-6einbent 6 21 nasopharynx nasopharynx NN cord-352796-6einbent 6 22 and and CC cord-352796-6einbent 6 23 subsequent subsequent JJ cord-352796-6einbent 6 24 access access NN cord-352796-6einbent 6 25 to to IN cord-352796-6einbent 6 26 the the DT cord-352796-6einbent 6 27 lungs lung NNS cord-352796-6einbent 6 28 and and CC cord-352796-6einbent 6 29 gut gut NN cord-352796-6einbent 6 30 . . . cord-352796-6einbent 7 1 Adenoviruses adenovirus NNS cord-352796-6einbent 7 2 and and CC cord-352796-6einbent 7 3 influenza influenza NN cord-352796-6einbent 7 4 viruses virus NNS cord-352796-6einbent 7 5 share share VBP cord-352796-6einbent 7 6 this this DT cord-352796-6einbent 7 7 ocular ocular JJ cord-352796-6einbent 7 8 tropism tropism NN cord-352796-6einbent 7 9 and and CC cord-352796-6einbent 7 10 despite despite IN cord-352796-6einbent 7 11 differing differ VBG cord-352796-6einbent 7 12 ocular ocular JJ cord-352796-6einbent 7 13 and and CC cord-352796-6einbent 7 14 systemic systemic JJ cord-352796-6einbent 7 15 manifestations manifestation NNS cord-352796-6einbent 7 16 and and CC cord-352796-6einbent 7 17 disease disease NN cord-352796-6einbent 7 18 patterns pattern NNS cord-352796-6einbent 7 19 , , , cord-352796-6einbent 7 20 common common JJ cord-352796-6einbent 7 21 lessons lesson NNS cord-352796-6einbent 7 22 , , , cord-352796-6einbent 7 23 particularly particularly RB cord-352796-6einbent 7 24 in in IN cord-352796-6einbent 7 25 management management NN cord-352796-6einbent 7 26 , , , cord-352796-6einbent 7 27 emerge emerge VB cord-352796-6einbent 7 28 . . . cord-352796-6einbent 8 1 Slit slit JJ cord-352796-6einbent 8 2 lamp lamp NN cord-352796-6einbent 8 3 usage usage NN cord-352796-6einbent 8 4 places place NNS cord-352796-6einbent 8 5 ophthalmologists ophthalmologist NNS cord-352796-6einbent 8 6 at at IN cord-352796-6einbent 8 7 particular particular JJ cord-352796-6einbent 8 8 risk risk NN cord-352796-6einbent 8 9 of of IN cord-352796-6einbent 8 10 exposure exposure NN cord-352796-6einbent 8 11 to to IN cord-352796-6einbent 8 12 high high JJ cord-352796-6einbent 8 13 viral viral JJ cord-352796-6einbent 8 14 loads load NNS cord-352796-6einbent 8 15 ( ( -LRB- cord-352796-6einbent 8 16 and and CC cord-352796-6einbent 8 17 poor poor JJ cord-352796-6einbent 8 18 prognosis prognosis NN cord-352796-6einbent 8 19 ) ) -RRB- cord-352796-6einbent 8 20 and and CC cord-352796-6einbent 8 21 as as IN cord-352796-6einbent 8 22 for for IN cord-352796-6einbent 8 23 adenoviral adenoviral NNP cord-352796-6einbent 8 24 epidemics epidemic NNS cord-352796-6einbent 8 25 , , , cord-352796-6einbent 8 26 this this DT cord-352796-6einbent 8 27 may may MD cord-352796-6einbent 8 28 be be VB cord-352796-6einbent 8 29 a a DT cord-352796-6einbent 8 30 setting setting NN cord-352796-6einbent 8 31 for for IN cord-352796-6einbent 8 32 disease disease NN cord-352796-6einbent 8 33 transmission transmission NN cord-352796-6einbent 8 34 . . . cord-352796-6einbent 9 1 Local local JJ cord-352796-6einbent 9 2 , , , cord-352796-6einbent 9 3 rather rather RB cord-352796-6einbent 9 4 than than IN cord-352796-6einbent 9 5 systemic systemic JJ cord-352796-6einbent 9 6 treatments treatment NNS cord-352796-6einbent 9 7 blocking block VBG cord-352796-6einbent 9 8 virus virus NN cord-352796-6einbent 9 9 binding bind VBG cord-352796-6einbent 9 10 in in IN cord-352796-6einbent 9 11 this this DT cord-352796-6einbent 9 12 pathway pathway NN cord-352796-6einbent 9 13 ( ( -LRB- cord-352796-6einbent 9 14 advocated advocate VBN cord-352796-6einbent 9 15 for for IN cord-352796-6einbent 9 16 adenovirus adenovirus NN cord-352796-6einbent 9 17 ) ) -RRB- cord-352796-6einbent 9 18 are be VBP cord-352796-6einbent 9 19 worth worth JJ cord-352796-6einbent 9 20 considering consider VBG cord-352796-6einbent 9 21 . . . cord-352796-6einbent 10 1 This this DT cord-352796-6einbent 10 2 pathway pathway NN cord-352796-6einbent 10 3 is be VBZ cord-352796-6einbent 10 4 accessible accessible JJ cord-352796-6einbent 10 5 with with IN cord-352796-6einbent 10 6 eye eye NN cord-352796-6einbent 10 7 drops drop NNS cord-352796-6einbent 10 8 or or CC cord-352796-6einbent 10 9 aerosols aerosol NNS cord-352796-6einbent 10 10 containing contain VBG cord-352796-6einbent 10 11 drugs drug NNS cord-352796-6einbent 10 12 which which WDT cord-352796-6einbent 10 13 appear appear VBP cord-352796-6einbent 10 14 efficacious efficacious JJ cord-352796-6einbent 10 15 via via IN cord-352796-6einbent 10 16 systemic systemic JJ cord-352796-6einbent 10 17 administration administration NN cord-352796-6einbent 10 18 . . . cord-352796-6einbent 11 1 A a DT cord-352796-6einbent 11 2 combination combination NN cord-352796-6einbent 11 3 such such JJ cord-352796-6einbent 11 4 as as IN cord-352796-6einbent 11 5 hydroxychloroquine hydroxychloroquine NNP cord-352796-6einbent 11 6 , , , cord-352796-6einbent 11 7 azithromycin azithromycin NN cord-352796-6einbent 11 8 and and CC cord-352796-6einbent 11 9 zinc zinc NN cord-352796-6einbent 11 10 , , , cord-352796-6einbent 11 11 all all DT cord-352796-6einbent 11 12 of of IN cord-352796-6einbent 11 13 which which WDT cord-352796-6einbent 11 14 have have VBP cord-352796-6einbent 11 15 previously previously RB cord-352796-6einbent 11 16 been be VBN cord-352796-6einbent 11 17 used use VBN cord-352796-6einbent 11 18 topically topically RB cord-352796-6einbent 11 19 in in IN cord-352796-6einbent 11 20 the the DT cord-352796-6einbent 11 21 eye eye NN cord-352796-6einbent 11 22 and and CC cord-352796-6einbent 11 23 which which WDT cord-352796-6einbent 11 24 work work VBP cord-352796-6einbent 11 25 at at IN cord-352796-6einbent 11 26 least least JJS cord-352796-6einbent 11 27 in in IN cord-352796-6einbent 11 28 part part NN cord-352796-6einbent 11 29 by by IN cord-352796-6einbent 11 30 blocking block VBG cord-352796-6einbent 11 31 ACE2 ACE2 NNP cord-352796-6einbent 11 32 receptors receptor NNS cord-352796-6einbent 11 33 , , , cord-352796-6einbent 11 34 may may MD cord-352796-6einbent 11 35 offer offer VB cord-352796-6einbent 11 36 a a DT cord-352796-6einbent 11 37 safe safe JJ cord-352796-6einbent 11 38 , , , cord-352796-6einbent 11 39 cost cost NN cord-352796-6einbent 11 40 - - HYPH cord-352796-6einbent 11 41 effective effective JJ cord-352796-6einbent 11 42 and and CC cord-352796-6einbent 11 43 resource resource NN cord-352796-6einbent 11 44 - - HYPH cord-352796-6einbent 11 45 sparing spare VBG cord-352796-6einbent 11 46 intervention intervention NN cord-352796-6einbent 11 47 . . . cord-352796-6einbent 12 1 Unexpectedly unexpectedly RB cord-352796-6einbent 12 2 , , , cord-352796-6einbent 12 3 ophthalmology ophthalmology NN cord-352796-6einbent 12 4 may may MD cord-352796-6einbent 12 5 be be VB cord-352796-6einbent 12 6 playing play VBG cord-352796-6einbent 12 7 a a DT cord-352796-6einbent 12 8 central central JJ cord-352796-6einbent 12 9 role role NN cord-352796-6einbent 12 10 in in IN cord-352796-6einbent 12 11 the the DT cord-352796-6einbent 12 12 current current JJ cord-352796-6einbent 12 13 Coronavirus Coronavirus NNP cord-352796-6einbent 12 14 Disease Disease NNP cord-352796-6einbent 12 15 2019 2019 CD cord-352796-6einbent 12 16 ( ( -LRB- cord-352796-6einbent 12 17 COVID- covid- NN cord-352796-6einbent 12 18 19 19 CD cord-352796-6einbent 12 19 ) ) -RRB- cord-352796-6einbent 12 20 epidemic epidemic NN cord-352796-6einbent 12 21 . . . cord-352796-6einbent 13 1 The the DT cord-352796-6einbent 13 2 harbinger harbinger NN cord-352796-6einbent 13 3 of of IN cord-352796-6einbent 13 4 the the DT cord-352796-6einbent 13 5 third third JJ cord-352796-6einbent 13 6 zoonotic zoonotic JJ cord-352796-6einbent 13 7 coronavirus coronavirus NN cord-352796-6einbent 13 8 epidemic epidemic NN cord-352796-6einbent 13 9 in in IN cord-352796-6einbent 13 10 as as RB cord-352796-6einbent 13 11 many many JJ cord-352796-6einbent 13 12 decades decade NNS cord-352796-6einbent 13 13 ( ( -LRB- cord-352796-6einbent 13 14 1 1 CD cord-352796-6einbent 13 15 ) ) -RRB- cord-352796-6einbent 13 16 , , , cord-352796-6einbent 13 17 was be VBD cord-352796-6einbent 13 18 Dr Dr NNP cord-352796-6einbent 13 19 Li Li NNP cord-352796-6einbent 13 20 Wenliang Wenliang NNP cord-352796-6einbent 13 21 , , , cord-352796-6einbent 13 22 an an DT cord-352796-6einbent 13 23 ophthalmologist ophthalmologist NN cord-352796-6einbent 13 24 , , , cord-352796-6einbent 13 25 who who WP cord-352796-6einbent 13 26 died die VBD cord-352796-6einbent 13 27 following follow VBG cord-352796-6einbent 13 28 infection infection NN cord-352796-6einbent 13 29 with with IN cord-352796-6einbent 13 30 COVID-19 COVID-19 NNP cord-352796-6einbent 13 31 ( ( -LRB- cord-352796-6einbent 13 32 2 2 CD cord-352796-6einbent 13 33 , , , cord-352796-6einbent 13 34 3 3 CD cord-352796-6einbent 13 35 ) ) -RRB- cord-352796-6einbent 13 36 . . . cord-352796-6einbent 14 1 It -PRON- PRP cord-352796-6einbent 14 2 was be VBD cord-352796-6einbent 14 3 thought think VBN cord-352796-6einbent 14 4 he -PRON- PRP cord-352796-6einbent 14 5 was be VBD cord-352796-6einbent 14 6 infected infect VBN cord-352796-6einbent 14 7 during during IN cord-352796-6einbent 14 8 examination examination NN cord-352796-6einbent 14 9 of of IN cord-352796-6einbent 14 10 a a DT cord-352796-6einbent 14 11 patient patient NN cord-352796-6einbent 14 12 with with IN cord-352796-6einbent 14 13 angle angle NN cord-352796-6einbent 14 14 closure closure NN cord-352796-6einbent 14 15 glaucoma glaucoma NN cord-352796-6einbent 14 16 in in IN cord-352796-6einbent 14 17 the the DT cord-352796-6einbent 14 18 second second JJ cord-352796-6einbent 14 19 week week NN cord-352796-6einbent 14 20 of of IN cord-352796-6einbent 14 21 January January NNP cord-352796-6einbent 14 22 2020 2020 CD cord-352796-6einbent 14 23 . . . cord-352796-6einbent 15 1 He -PRON- PRP cord-352796-6einbent 15 2 suspected suspect VBD cord-352796-6einbent 15 3 an an DT cord-352796-6einbent 15 4 outbreak outbreak NN cord-352796-6einbent 15 5 after after IN cord-352796-6einbent 15 6 seeing see VBG cord-352796-6einbent 15 7 patients patient NNS cord-352796-6einbent 15 8 with with IN cord-352796-6einbent 15 9 SARS SARS NNP cord-352796-6einbent 15 10 - - HYPH cord-352796-6einbent 15 11 like like JJ cord-352796-6einbent 15 12 symptoms symptom NNS cord-352796-6einbent 15 13 and and CC cord-352796-6einbent 15 14 the the DT cord-352796-6einbent 15 15 system system NN cord-352796-6einbent 15 16 failure failure NN cord-352796-6einbent 15 17 to to TO cord-352796-6einbent 15 18 heed heed VB cord-352796-6einbent 15 19 his -PRON- PRP$ cord-352796-6einbent 15 20 warning warning NN cord-352796-6einbent 15 21 may may MD cord-352796-6einbent 15 22 well well RB cord-352796-6einbent 15 23 have have VB cord-352796-6einbent 15 24 changed change VBN cord-352796-6einbent 15 25 the the DT cord-352796-6einbent 15 26 course course NN cord-352796-6einbent 15 27 of of IN cord-352796-6einbent 15 28 world world NN cord-352796-6einbent 15 29 history history NN cord-352796-6einbent 15 30 . . . cord-352796-6einbent 16 1 The the DT cord-352796-6einbent 16 2 second second JJ cord-352796-6einbent 16 3 instructive instructive JJ cord-352796-6einbent 16 4 case case NN cord-352796-6einbent 16 5 is be VBZ cord-352796-6einbent 16 6 that that DT cord-352796-6einbent 16 7 of of IN cord-352796-6einbent 16 8 the the DT cord-352796-6einbent 16 9 respiratory respiratory JJ cord-352796-6einbent 16 10 physician physician NN cord-352796-6einbent 16 11 Guangfa Guangfa NNP cord-352796-6einbent 16 12 Wang Wang NNP cord-352796-6einbent 16 13 ( ( -LRB- cord-352796-6einbent 16 14 4 4 CD cord-352796-6einbent 16 15 ) ) -RRB- cord-352796-6einbent 16 16 . . . cord-352796-6einbent 17 1 Days day NNS cord-352796-6einbent 17 2 before before IN cord-352796-6einbent 17 3 pneumonia pneumonia NN cord-352796-6einbent 17 4 onset onset NN cord-352796-6einbent 17 5 , , , cord-352796-6einbent 17 6 his -PRON- PRP$ cord-352796-6einbent 17 7 earliest early JJS cord-352796-6einbent 17 8 symptoms symptom NNS cord-352796-6einbent 17 9 related relate VBN cord-352796-6einbent 17 10 to to IN cord-352796-6einbent 17 11 left left JJ cord-352796-6einbent 17 12 conjunctivitis conjunctivitis NN cord-352796-6einbent 17 13 , , , cord-352796-6einbent 17 14 then then RB cord-352796-6einbent 17 15 catarrhal catarrhal VBZ cord-352796-6einbent 17 16 symptoms symptom NNS cord-352796-6einbent 17 17 and and CC cord-352796-6einbent 17 18 fever fever NN cord-352796-6einbent 17 19 which which WDT cord-352796-6einbent 17 20 developed develop VBD cord-352796-6einbent 17 21 after after IN cord-352796-6einbent 17 22 2 2 CD cord-352796-6einbent 17 23 - - SYM cord-352796-6einbent 17 24 3 3 CD cord-352796-6einbent 17 25 hours hour NNS cord-352796-6einbent 17 26 , , , cord-352796-6einbent 17 27 slower slow JJR cord-352796-6einbent 17 28 than than IN cord-352796-6einbent 17 29 might may MD cord-352796-6einbent 17 30 be be VB cord-352796-6einbent 17 31 expected expect VBN cord-352796-6einbent 17 32 from from IN cord-352796-6einbent 17 33 older old JJR cord-352796-6einbent 17 34 studies study NNS cord-352796-6einbent 17 35 tracing trace VBG cord-352796-6einbent 17 36 the the DT cord-352796-6einbent 17 37 passage passage NN cord-352796-6einbent 17 38 of of IN cord-352796-6einbent 17 39 bacteria bacteria NNS cord-352796-6einbent 17 40 through through IN cord-352796-6einbent 17 41 the the DT cord-352796-6einbent 17 42 lacrimal lacrimal JJ cord-352796-6einbent 17 43 drainage drainage NN cord-352796-6einbent 17 44 system system NN cord-352796-6einbent 17 45 ( ( -LRB- cord-352796-6einbent 17 46 5 5 CD cord-352796-6einbent 17 47 ) ) -RRB- cord-352796-6einbent 17 48 . . . cord-352796-6einbent 18 1 While while IN cord-352796-6einbent 18 2 an an DT cord-352796-6einbent 18 3 N95 N95 NNP cord-352796-6einbent 18 4 respirator respirator NN cord-352796-6einbent 18 5 was be VBD cord-352796-6einbent 18 6 worn wear VBN cord-352796-6einbent 18 7 , , , cord-352796-6einbent 18 8 offering offer VBG cord-352796-6einbent 18 9 protection protection NN cord-352796-6einbent 18 10 from from IN cord-352796-6einbent 18 11 infection infection NN cord-352796-6einbent 18 12 via via IN cord-352796-6einbent 18 13 oro oro NNP cord-352796-6einbent 18 14 - - HYPH cord-352796-6einbent 18 15 nasal nasal NN cord-352796-6einbent 18 16 pathways pathway NNS cord-352796-6einbent 18 17 , , , cord-352796-6einbent 18 18 eye eye NN cord-352796-6einbent 18 19 protection protection NN cord-352796-6einbent 18 20 was be VBD cord-352796-6einbent 18 21 not not RB cord-352796-6einbent 18 22 . . . cord-352796-6einbent 19 1 Evidence evidence NN cord-352796-6einbent 19 2 that that IN cord-352796-6einbent 19 3 ocular ocular JJ cord-352796-6einbent 19 4 and and CC cord-352796-6einbent 19 5 periocular periocular JJ cord-352796-6einbent 19 6 tissue tissue NN cord-352796-6einbent 19 7 may may MD cord-352796-6einbent 19 8 be be VB cord-352796-6einbent 19 9 uniquely uniquely RB cord-352796-6einbent 19 10 placed place VBN cord-352796-6einbent 19 11 as as IN cord-352796-6einbent 19 12 an an DT cord-352796-6einbent 19 13 entry entry NN cord-352796-6einbent 19 14 point point NN cord-352796-6einbent 19 15 for for IN cord-352796-6einbent 19 16 viral viral JJ cord-352796-6einbent 19 17 invasion invasion NN cord-352796-6einbent 19 18 will will MD cord-352796-6einbent 19 19 be be VB cord-352796-6einbent 19 20 reviewed review VBN cord-352796-6einbent 19 21 . . . cord-352796-6einbent 20 1 At at IN cord-352796-6einbent 20 2 the the DT cord-352796-6einbent 20 3 height height NN cord-352796-6einbent 20 4 of of IN cord-352796-6einbent 20 5 the the DT cord-352796-6einbent 20 6 1918 1918 CD cord-352796-6einbent 20 7 world world NN cord-352796-6einbent 20 8 influenza influenza NN cord-352796-6einbent 20 9 epidemic epidemic NN cord-352796-6einbent 20 10 , , , cord-352796-6einbent 20 11 a a DT cord-352796-6einbent 20 12 landmark landmark NN cord-352796-6einbent 20 13 paper paper NN cord-352796-6einbent 20 14 appeared appear VBD cord-352796-6einbent 20 15 , , , cord-352796-6einbent 20 16 proposing propose VBG cord-352796-6einbent 20 17 transmission transmission NN cord-352796-6einbent 20 18 of of IN cord-352796-6einbent 20 19 acute acute JJ cord-352796-6einbent 20 20 respiratory respiratory JJ cord-352796-6einbent 20 21 infections infection NNS cord-352796-6einbent 20 22 via via IN cord-352796-6einbent 20 23 the the DT cord-352796-6einbent 20 24 eye eye NN cord-352796-6einbent 20 25 and and CC cord-352796-6einbent 20 26 lacrimal lacrimal NN cord-352796-6einbent 20 27 - - HYPH cord-352796-6einbent 20 28 nasal nasal NN cord-352796-6einbent 20 29 pathway pathway NN cord-352796-6einbent 20 30 ( ( -LRB- cord-352796-6einbent 20 31 5 5 CD cord-352796-6einbent 20 32 ) ) -RRB- cord-352796-6einbent 21 1 ( ( -LRB- cord-352796-6einbent 21 2 Figure figure NN cord-352796-6einbent 21 3 1 1 CD cord-352796-6einbent 21 4 ) ) -RRB- cord-352796-6einbent 21 5 . . . cord-352796-6einbent 22 1 It -PRON- PRP cord-352796-6einbent 22 2 was be VBD cord-352796-6einbent 22 3 noted note VBN cord-352796-6einbent 22 4 that that IN cord-352796-6einbent 22 5 this this DT cord-352796-6einbent 22 6 pathway pathway NN cord-352796-6einbent 22 7 had have VBD cord-352796-6einbent 22 8 been be VBN cord-352796-6einbent 22 9 " " `` cord-352796-6einbent 22 10 disregarded disregard VBN cord-352796-6einbent 22 11 in in IN cord-352796-6einbent 22 12 planning plan VBG cord-352796-6einbent 22 13 measures measure NNS cord-352796-6einbent 22 14 for for IN cord-352796-6einbent 22 15 the the DT cord-352796-6einbent 22 16 prevention prevention NN cord-352796-6einbent 22 17 of of IN cord-352796-6einbent 22 18 the the DT cord-352796-6einbent 22 19 spread spread NN cord-352796-6einbent 22 20 of of IN cord-352796-6einbent 22 21 contagious contagious JJ cord-352796-6einbent 22 22 diseases disease NNS cord-352796-6einbent 22 23 " " '' cord-352796-6einbent 22 24 and and CC cord-352796-6einbent 22 25 it -PRON- PRP cord-352796-6einbent 22 26 would would MD cord-352796-6einbent 22 27 appear appear VB cord-352796-6einbent 22 28 that that DT cord-352796-6einbent 22 29 little little JJ cord-352796-6einbent 22 30 has have VBZ cord-352796-6einbent 22 31 changed change VBN cord-352796-6einbent 22 32 . . . cord-352796-6einbent 23 1 Figure figure NN cord-352796-6einbent 23 2 1 1 CD cord-352796-6einbent 23 3 . . . cord-352796-6einbent 24 1 The the DT cord-352796-6einbent 24 2 lacrimatory lacrimatory NN cord-352796-6einbent 24 3 - - HYPH cord-352796-6einbent 24 4 nasal nasal NN cord-352796-6einbent 24 5 mechanism mechanism NN cord-352796-6einbent 24 6 for for IN cord-352796-6einbent 24 7 the the DT cord-352796-6einbent 24 8 mechanical mechanical JJ cord-352796-6einbent 24 9 disposition disposition NN cord-352796-6einbent 24 10 of of IN cord-352796-6einbent 24 11 organisms organism NNS cord-352796-6einbent 24 12 entering enter VBG cord-352796-6einbent 24 13 the the DT cord-352796-6einbent 24 14 upper upper JJ cord-352796-6einbent 24 15 respiratory respiratory JJ cord-352796-6einbent 24 16 tract tract NN cord-352796-6einbent 24 17 ( ( -LRB- cord-352796-6einbent 24 18 5 5 CD cord-352796-6einbent 24 19 ) ) -RRB- cord-352796-6einbent 24 20 . . . cord-352796-6einbent 25 1 A a DT cord-352796-6einbent 25 2 third third JJ cord-352796-6einbent 25 3 factor factor NN cord-352796-6einbent 25 4 in in IN cord-352796-6einbent 25 5 this this DT cord-352796-6einbent 25 6 perfect perfect JJ cord-352796-6einbent 25 7 storm storm NN cord-352796-6einbent 25 8 is be VBZ cord-352796-6einbent 25 9 the the DT cord-352796-6einbent 25 10 well well RB cord-352796-6einbent 25 11 - - HYPH cord-352796-6einbent 25 12 established establish VBN cord-352796-6einbent 25 13 but but CC cord-352796-6einbent 25 14 not not RB cord-352796-6einbent 25 15 well well RB cord-352796-6einbent 25 16 recognized recognize VBN cord-352796-6einbent 25 17 coronavirus coronavirus NN cord-352796-6einbent 25 18 ocular ocular JJ cord-352796-6einbent 25 19 tropism tropism NN cord-352796-6einbent 25 20 ( ( -LRB- cord-352796-6einbent 25 21 6 6 CD cord-352796-6einbent 25 22 ) ) -RRB- cord-352796-6einbent 25 23 . . . cord-352796-6einbent 26 1 The the DT cord-352796-6einbent 26 2 study study NN cord-352796-6einbent 26 3 of of IN cord-352796-6einbent 26 4 oculotropic oculotropic NNP cord-352796-6einbent 26 5 influenza influenza NN cord-352796-6einbent 26 6 and and CC cord-352796-6einbent 26 7 adenoviruses adenovirus NNS cord-352796-6einbent 26 8 ( ( -LRB- cord-352796-6einbent 26 9 7 7 CD cord-352796-6einbent 26 10 - - SYM cord-352796-6einbent 26 11 9 9 CD cord-352796-6einbent 26 12 ) ) -RRB- cord-352796-6einbent 26 13 sets set VBZ cord-352796-6einbent 26 14 precedents precedent NNS cord-352796-6einbent 26 15 for for IN cord-352796-6einbent 26 16 disease disease NN cord-352796-6einbent 26 17 patterns pattern NNS cord-352796-6einbent 26 18 , , , cord-352796-6einbent 26 19 bought buy VBN cord-352796-6einbent 26 20 into into IN cord-352796-6einbent 26 21 focus focus NN cord-352796-6einbent 26 22 by by IN cord-352796-6einbent 26 23 coronaviruses coronaviruse NNS cord-352796-6einbent 26 24 . . . cord-352796-6einbent 27 1 Whereas whereas IN cord-352796-6einbent 27 2 influenza influenza NN cord-352796-6einbent 27 3 viruses virus NNS cord-352796-6einbent 27 4 generally generally RB cord-352796-6einbent 27 5 represent represent VBP cord-352796-6einbent 27 6 a a DT cord-352796-6einbent 27 7 respiratory respiratory JJ cord-352796-6einbent 27 8 pathogen pathogen NN cord-352796-6einbent 27 9 and and CC cord-352796-6einbent 27 10 only only RB cord-352796-6einbent 27 11 occasionally occasionally RB cord-352796-6einbent 27 12 cause cause VBP cord-352796-6einbent 27 13 ocular ocular JJ cord-352796-6einbent 27 14 complications complication NNS cord-352796-6einbent 27 15 , , , cord-352796-6einbent 27 16 adenoviruses adenovirus NNS cord-352796-6einbent 27 17 mirror mirror VBP cord-352796-6einbent 27 18 image image NN cord-352796-6einbent 27 19 this this DT cord-352796-6einbent 27 20 disease disease NN cord-352796-6einbent 27 21 pattern pattern NN cord-352796-6einbent 27 22 , , , cord-352796-6einbent 27 23 causing cause VBG cord-352796-6einbent 27 24 severe severe JJ cord-352796-6einbent 27 25 ocular ocular JJ cord-352796-6einbent 27 26 surface surface NN cord-352796-6einbent 27 27 disease disease NN cord-352796-6einbent 27 28 , , , cord-352796-6einbent 27 29 and and CC cord-352796-6einbent 27 30 are be VBP cord-352796-6einbent 27 31 often often RB cord-352796-6einbent 27 32 highly highly RB cord-352796-6einbent 27 33 contagious contagious JJ cord-352796-6einbent 27 34 ( ( -LRB- cord-352796-6einbent 27 35 known know VBN cord-352796-6einbent 27 36 as as IN cord-352796-6einbent 27 37 " " `` cord-352796-6einbent 27 38 eye eye NN cord-352796-6einbent 27 39 hospital hospital NN cord-352796-6einbent 27 40 eye"(10 eye"(10 NNP cord-352796-6einbent 27 41 ) ) -RRB- cord-352796-6einbent 27 42 ) ) -RRB- cord-352796-6einbent 27 43 with with IN cord-352796-6einbent 27 44 fewer few JJR cord-352796-6einbent 27 45 , , , cord-352796-6einbent 27 46 seldom seldom RB cord-352796-6einbent 27 47 lethal lethal JJ cord-352796-6einbent 27 48 , , , cord-352796-6einbent 27 49 systemic systemic JJ cord-352796-6einbent 27 50 manifestations manifestation NNS cord-352796-6einbent 27 51 . . . cord-352796-6einbent 28 1 Thus thus RB cord-352796-6einbent 28 2 , , , cord-352796-6einbent 28 3 all all DT cord-352796-6einbent 28 4 three three CD cord-352796-6einbent 28 5 virus virus NN cord-352796-6einbent 28 6 types type NNS cord-352796-6einbent 28 7 share share VBP cord-352796-6einbent 28 8 a a DT cord-352796-6einbent 28 9 common common JJ cord-352796-6einbent 28 10 ocular ocular JJ cord-352796-6einbent 28 11 entrée entrée NN cord-352796-6einbent 28 12 but but CC cord-352796-6einbent 28 13 vary vary VBP cord-352796-6einbent 28 14 in in IN cord-352796-6einbent 28 15 their -PRON- PRP$ cord-352796-6einbent 28 16 degree degree NN cord-352796-6einbent 28 17 of of IN cord-352796-6einbent 28 18 contagion contagion NN cord-352796-6einbent 28 19 , , , cord-352796-6einbent 28 20 ocular ocular JJ cord-352796-6einbent 28 21 versus versus IN cord-352796-6einbent 28 22 respiratory respiratory JJ cord-352796-6einbent 28 23 / / SYM cord-352796-6einbent 28 24 system system NN cord-352796-6einbent 28 25 impact impact NN cord-352796-6einbent 28 26 and and CC cord-352796-6einbent 28 27 lethality lethality NN cord-352796-6einbent 28 28 . . . cord-352796-6einbent 29 1 Taken take VBN cord-352796-6einbent 29 2 as as IN cord-352796-6einbent 29 3 a a DT cord-352796-6einbent 29 4 whole whole NN cord-352796-6einbent 29 5 , , , cord-352796-6einbent 29 6 these these DT cord-352796-6einbent 29 7 disease disease NN cord-352796-6einbent 29 8 patterns pattern NNS cord-352796-6einbent 29 9 have have VBP cord-352796-6einbent 29 10 implications implication NNS cord-352796-6einbent 29 11 for for IN cord-352796-6einbent 29 12 more more JJR cord-352796-6einbent 29 13 effective effective JJ cord-352796-6einbent 29 14 management management NN cord-352796-6einbent 29 15 strategies strategy NNS cord-352796-6einbent 29 16 . . . cord-352796-6einbent 30 1 Dr Dr NNP cord-352796-6einbent 30 2 Li Li NNP cord-352796-6einbent 30 3 Wenliang Wenliang NNP cord-352796-6einbent 30 4 's 's POS cord-352796-6einbent 30 5 death death NN cord-352796-6einbent 30 6 and and CC cord-352796-6einbent 30 7 the the DT cord-352796-6einbent 30 8 apparent apparent JJ cord-352796-6einbent 30 9 high high JJ cord-352796-6einbent 30 10 infection infection NN cord-352796-6einbent 30 11 rate rate NN cord-352796-6einbent 30 12 in in IN cord-352796-6einbent 30 13 ophthalmologists ophthalmologist NNS cord-352796-6einbent 30 14 ( ( -LRB- cord-352796-6einbent 30 15 and and CC cord-352796-6einbent 30 16 ENT ENT NNP cord-352796-6einbent 30 17 surgeons surgeon NNS cord-352796-6einbent 30 18 ) ) -RRB- cord-352796-6einbent 30 19 ( ( -LRB- cord-352796-6einbent 30 20 11 11 CD cord-352796-6einbent 30 21 ) ) -RRB- cord-352796-6einbent 30 22 , , , cord-352796-6einbent 30 23 attributed attribute VBN cord-352796-6einbent 30 24 to to IN cord-352796-6einbent 30 25 the the DT cord-352796-6einbent 30 26 high high JJ cord-352796-6einbent 30 27 viral viral JJ cord-352796-6einbent 30 28 shedding shed VBG cord-352796-6einbent 30 29 from from IN cord-352796-6einbent 30 30 the the DT cord-352796-6einbent 30 31 nasal nasal NN cord-352796-6einbent 30 32 cavity cavity NN cord-352796-6einbent 30 33 , , , cord-352796-6einbent 30 34 should should MD cord-352796-6einbent 30 35 not not RB cord-352796-6einbent 30 36 be be VB cord-352796-6einbent 30 37 unexpected unexpected JJ cord-352796-6einbent 30 38 . . . cord-352796-6einbent 31 1 A a DT cord-352796-6einbent 31 2 high high JJ cord-352796-6einbent 31 3 initial initial JJ cord-352796-6einbent 31 4 viral viral JJ cord-352796-6einbent 31 5 load load NN cord-352796-6einbent 31 6 is be VBZ cord-352796-6einbent 31 7 associated associate VBN cord-352796-6einbent 31 8 with with IN cord-352796-6einbent 31 9 poor poor JJ cord-352796-6einbent 31 10 prognosis prognosis NN cord-352796-6einbent 31 11 ( ( -LRB- cord-352796-6einbent 31 12 12 12 CD cord-352796-6einbent 31 13 ) ) -RRB- cord-352796-6einbent 31 14 and and CC cord-352796-6einbent 31 15 ophthalmologists ophthalmologist NNS cord-352796-6einbent 31 16 are be VBP cord-352796-6einbent 31 17 particularly particularly RB cord-352796-6einbent 31 18 at at IN cord-352796-6einbent 31 19 risk risk NN cord-352796-6einbent 31 20 , , , cord-352796-6einbent 31 21 since since IN cord-352796-6einbent 31 22 ophthalmic ophthalmic JJ cord-352796-6einbent 31 23 practice practice NN cord-352796-6einbent 31 24 involves involve VBZ cord-352796-6einbent 31 25 very very RB cord-352796-6einbent 31 26 close close JJ cord-352796-6einbent 31 27 ophthalmologist ophthalmologist NN cord-352796-6einbent 31 28 - - HYPH cord-352796-6einbent 31 29 patient patient NN cord-352796-6einbent 31 30 physical physical JJ cord-352796-6einbent 31 31 proximity proximity NN cord-352796-6einbent 31 32 . . . cord-352796-6einbent 32 1 This this DT cord-352796-6einbent 32 2 is be VBZ cord-352796-6einbent 32 3 necessitated necessitate VBN cord-352796-6einbent 32 4 by by IN cord-352796-6einbent 32 5 optical optical JJ cord-352796-6einbent 32 6 imperatives imperative NNS cord-352796-6einbent 32 7 to to TO cord-352796-6einbent 32 8 optimise optimise VB cord-352796-6einbent 32 9 image image NN cord-352796-6einbent 32 10 quality quality NN cord-352796-6einbent 32 11 by by IN cord-352796-6einbent 32 12 close close JJ cord-352796-6einbent 32 13 alignment alignment NN cord-352796-6einbent 32 14 of of IN cord-352796-6einbent 32 15 imaging image VBG cord-352796-6einbent 32 16 devices device NNS cord-352796-6einbent 32 17 to to IN cord-352796-6einbent 32 18 the the DT cord-352796-6einbent 32 19 eye eye NN cord-352796-6einbent 32 20 . . . cord-352796-6einbent 33 1 Slit slit JJ cord-352796-6einbent 33 2 lamp lamp NN cord-352796-6einbent 33 3 biomicroscopy biomicroscopy NN cord-352796-6einbent 33 4 is be VBZ cord-352796-6einbent 33 5 the the DT cord-352796-6einbent 33 6 cornerstone cornerstone NN cord-352796-6einbent 33 7 of of IN cord-352796-6einbent 33 8 ophthalmic ophthalmic JJ cord-352796-6einbent 33 9 practice practice NN cord-352796-6einbent 33 10 and and CC cord-352796-6einbent 33 11 the the DT cord-352796-6einbent 33 12 slit slit JJ cord-352796-6einbent 33 13 lamp lamp NN cord-352796-6einbent 33 14 is be VBZ cord-352796-6einbent 33 15 also also RB cord-352796-6einbent 33 16 used use VBN cord-352796-6einbent 33 17 to to TO cord-352796-6einbent 33 18 carry carry VB cord-352796-6einbent 33 19 out out RP cord-352796-6einbent 33 20 surgical surgical JJ cord-352796-6einbent 33 21 procedures procedure NNS cord-352796-6einbent 33 22 . . . cord-352796-6einbent 34 1 The the DT cord-352796-6einbent 34 2 back back JJ cord-352796-6einbent 34 3 focal focal JJ cord-352796-6einbent 34 4 distance distance NN cord-352796-6einbent 34 5 ( ( -LRB- cord-352796-6einbent 34 6 the the DT cord-352796-6einbent 34 7 distance distance NN cord-352796-6einbent 34 8 of of IN cord-352796-6einbent 34 9 the the DT cord-352796-6einbent 34 10 subject subject NN cord-352796-6einbent 34 11 from from IN cord-352796-6einbent 34 12 the the DT cord-352796-6einbent 34 13 front front JJ cord-352796-6einbent 34 14 lens lens NN cord-352796-6einbent 34 15 surface surface NN cord-352796-6einbent 34 16 of of IN cord-352796-6einbent 34 17 the the DT cord-352796-6einbent 34 18 microscope microscope NN cord-352796-6einbent 34 19 ) ) -RRB- cord-352796-6einbent 34 20 , , , cord-352796-6einbent 34 21 is be VBZ cord-352796-6einbent 34 22 set set VBN cord-352796-6einbent 34 23 to to TO cord-352796-6einbent 34 24 give give VB cord-352796-6einbent 34 25 the the DT cord-352796-6einbent 34 26 surgeon surgeon NN cord-352796-6einbent 34 27 sufficient sufficient JJ cord-352796-6einbent 34 28 space space NN cord-352796-6einbent 34 29 for for IN cord-352796-6einbent 34 30 manipulation manipulation NN cord-352796-6einbent 34 31 ~ ~ NFP cord-352796-6einbent 34 32 11 11 CD cord-352796-6einbent 34 33 cm cm NNS cord-352796-6einbent 34 34 ( ( -LRB- cord-352796-6einbent 34 35 Figure figure NN cord-352796-6einbent 34 36 2A 2a CD cord-352796-6einbent 34 37 ) ) -RRB- cord-352796-6einbent 34 38 . . . cord-352796-6einbent 35 1 With with IN cord-352796-6einbent 35 2 the the DT cord-352796-6einbent 35 3 instrument instrument NN cord-352796-6einbent 35 4 body body NN cord-352796-6einbent 35 5 length length NN cord-352796-6einbent 35 6 added add VBN cord-352796-6einbent 35 7 , , , cord-352796-6einbent 35 8 the the DT cord-352796-6einbent 35 9 distance distance NN cord-352796-6einbent 35 10 from from IN cord-352796-6einbent 35 11 patient patient NN cord-352796-6einbent 35 12 to to IN cord-352796-6einbent 35 13 the the DT cord-352796-6einbent 35 14 surgeon surgeon NN cord-352796-6einbent 35 15 's 's POS cord-352796-6einbent 35 16 eye eye NN cord-352796-6einbent 35 17 is be VBZ cord-352796-6einbent 35 18 at at IN cord-352796-6einbent 35 19 a a DT cord-352796-6einbent 35 20 convenient convenient JJ cord-352796-6einbent 35 21 working working NN cord-352796-6einbent 35 22 distance distance NN cord-352796-6einbent 35 23 of of IN cord-352796-6einbent 35 24 ~ ~ CD cord-352796-6einbent 35 25 28 28 CD cord-352796-6einbent 35 26 - - SYM cord-352796-6einbent 35 27 30 30 CD cord-352796-6einbent 35 28 cm cm NN cord-352796-6einbent 35 29 . . . cord-352796-6einbent 36 1 This this DT cord-352796-6einbent 36 2 proximity proximity NN cord-352796-6einbent 36 3 and and CC cord-352796-6einbent 36 4 the the DT cord-352796-6einbent 36 5 possibility possibility NN cord-352796-6einbent 36 6 of of IN cord-352796-6einbent 36 7 cross cross NN cord-352796-6einbent 36 8 infection infection NN cord-352796-6einbent 36 9 between between IN cord-352796-6einbent 36 10 examiner examiner NN cord-352796-6einbent 36 11 and and CC cord-352796-6einbent 36 12 examinee examinee NN cord-352796-6einbent 36 13 has have VBZ cord-352796-6einbent 36 14 long long RB cord-352796-6einbent 36 15 been be VBN cord-352796-6einbent 36 16 recognized recognize VBN cord-352796-6einbent 36 17 and and CC cord-352796-6einbent 36 18 a a DT cord-352796-6einbent 36 19 protective protective JJ cord-352796-6einbent 36 20 , , , cord-352796-6einbent 36 21 transparent transparent JJ cord-352796-6einbent 36 22 , , , cord-352796-6einbent 36 23 typically typically RB cord-352796-6einbent 36 24 Perspex Perspex NNP cord-352796-6einbent 36 25 ® ® . cord-352796-6einbent 36 26 " " `` cord-352796-6einbent 36 27 breath breath NN cord-352796-6einbent 36 28 shield shield NN cord-352796-6einbent 36 29 " " '' cord-352796-6einbent 36 30 was be VBD cord-352796-6einbent 36 31 added add VBN cord-352796-6einbent 36 32 to to IN cord-352796-6einbent 36 33 slit slit NN cord-352796-6einbent 36 34 lamps lamp NNS cord-352796-6einbent 36 35 . . . cord-352796-6einbent 37 1 It -PRON- PRP cord-352796-6einbent 37 2 is be VBZ cord-352796-6einbent 37 3 evident evident JJ cord-352796-6einbent 37 4 in in IN cord-352796-6einbent 37 5 slit slit JJ cord-352796-6einbent 37 6 lamps lamp NNS cord-352796-6einbent 37 7 from from IN cord-352796-6einbent 37 8 as as RB cord-352796-6einbent 37 9 early early RB cord-352796-6einbent 37 10 as as IN cord-352796-6einbent 37 11 1919 1919 CD cord-352796-6einbent 37 12 ( ( -LRB- cord-352796-6einbent 37 13 13 13 CD cord-352796-6einbent 37 14 ) ) -RRB- cord-352796-6einbent 37 15 and and CC cord-352796-6einbent 37 16 may may MD cord-352796-6einbent 37 17 well well RB cord-352796-6einbent 37 18 have have VB cord-352796-6einbent 37 19 gained gain VBN cord-352796-6einbent 37 20 popularity popularity NN cord-352796-6einbent 37 21 during during IN cord-352796-6einbent 37 22 the the DT cord-352796-6einbent 37 23 era era NN cord-352796-6einbent 37 24 of of IN cord-352796-6einbent 37 25 the the DT cord-352796-6einbent 37 26 1918 1918 CD cord-352796-6einbent 37 27 influenza influenza NN cord-352796-6einbent 37 28 pandemic pandemic NN cord-352796-6einbent 37 29 . . . cord-352796-6einbent 38 1 The the DT cord-352796-6einbent 38 2 necessity necessity NN cord-352796-6einbent 38 3 for for IN cord-352796-6einbent 38 4 such such JJ cord-352796-6einbent 38 5 shields shield NNS cord-352796-6einbent 38 6 is be VBZ cord-352796-6einbent 38 7 readily readily RB cord-352796-6einbent 38 8 apparent apparent JJ cord-352796-6einbent 38 9 from from IN cord-352796-6einbent 38 10 studies study NNS cord-352796-6einbent 38 11 in in IN cord-352796-6einbent 38 12 which which WDT cord-352796-6einbent 38 13 exposure exposure NN cord-352796-6einbent 38 14 between between IN cord-352796-6einbent 38 15 two two CD cord-352796-6einbent 38 16 face face NN cord-352796-6einbent 38 17 - - HYPH cord-352796-6einbent 38 18 to to IN cord-352796-6einbent 38 19 - - HYPH cord-352796-6einbent 38 20 face face NN cord-352796-6einbent 38 21 breathing breathing NN cord-352796-6einbent 38 22 manikins manikin NNS cord-352796-6einbent 38 23 is be VBZ cord-352796-6einbent 38 24 measured measure VBN cord-352796-6einbent 38 25 This this DT cord-352796-6einbent 38 26 study study NN cord-352796-6einbent 38 27 concluded conclude VBD cord-352796-6einbent 38 28 that that IN cord-352796-6einbent 38 29 air air NN cord-352796-6einbent 38 30 exhaled exhale VBD cord-352796-6einbent 38 31 from from IN cord-352796-6einbent 38 32 human human JJ cord-352796-6einbent 38 33 respiration respiration NN cord-352796-6einbent 38 34 contains contain VBZ cord-352796-6einbent 38 35 contaminants contaminant NNS cord-352796-6einbent 38 36 and and CC cord-352796-6einbent 38 37 is be VBZ cord-352796-6einbent 38 38 able able JJ cord-352796-6einbent 38 39 to to TO cord-352796-6einbent 38 40 penetrate penetrate VB cord-352796-6einbent 38 41 the the DT cord-352796-6einbent 38 42 breathing breathing NN cord-352796-6einbent 38 43 zone zone NN cord-352796-6einbent 38 44 of of IN cord-352796-6einbent 38 45 other other JJ cord-352796-6einbent 38 46 nearby nearby JJ cord-352796-6einbent 38 47 persons person NNS cord-352796-6einbent 38 48 . . . cord-352796-6einbent 39 1 Of of IN cord-352796-6einbent 39 2 interest interest NN cord-352796-6einbent 39 3 is be VBZ cord-352796-6einbent 39 4 that that DT cord-352796-6einbent 39 5 exhalation exhalation NN cord-352796-6einbent 39 6 flow flow NN cord-352796-6einbent 39 7 may may MD cord-352796-6einbent 39 8 stratify stratify VB cord-352796-6einbent 39 9 in in IN cord-352796-6einbent 39 10 a a DT cord-352796-6einbent 39 11 horizontal horizontal JJ cord-352796-6einbent 39 12 layer layer NN cord-352796-6einbent 39 13 at at IN cord-352796-6einbent 39 14 breathing breathing NN cord-352796-6einbent 39 15 zone zone NN cord-352796-6einbent 39 16 height height NN cord-352796-6einbent 39 17 under under IN cord-352796-6einbent 39 18 certain certain JJ cord-352796-6einbent 39 19 conditions condition NNS cord-352796-6einbent 39 20 . . . cord-352796-6einbent 40 1 Thus thus RB cord-352796-6einbent 40 2 , , , cord-352796-6einbent 40 3 with with IN cord-352796-6einbent 40 4 slit slit JJ cord-352796-6einbent 40 5 lamp lamp NN cord-352796-6einbent 40 6 examination examination NN cord-352796-6einbent 40 7 , , , cord-352796-6einbent 40 8 the the DT cord-352796-6einbent 40 9 layer layer NN cord-352796-6einbent 40 10 of of IN cord-352796-6einbent 40 11 air air NN cord-352796-6einbent 40 12 between between IN cord-352796-6einbent 40 13 patient patient NN cord-352796-6einbent 40 14 and and CC cord-352796-6einbent 40 15 ophthalmologist ophthalmologist NN cord-352796-6einbent 40 16 may may MD cord-352796-6einbent 40 17 remain remain VB cord-352796-6einbent 40 18 stable stable JJ cord-352796-6einbent 40 19 , , , cord-352796-6einbent 40 20 exposing expose VBG cord-352796-6einbent 40 21 both both DT cord-352796-6einbent 40 22 individuals individual NNS cord-352796-6einbent 40 23 for for IN cord-352796-6einbent 40 24 the the DT cord-352796-6einbent 40 25 entire entire JJ cord-352796-6einbent 40 26 time time NN cord-352796-6einbent 40 27 of of IN cord-352796-6einbent 40 28 the the DT cord-352796-6einbent 40 29 examination examination NN cord-352796-6einbent 40 30 . . . cord-352796-6einbent 41 1 Breath Breath NNP cord-352796-6einbent 41 2 shields shield NNS cord-352796-6einbent 41 3 6 6 CD cord-352796-6einbent 41 4 are be VBP cord-352796-6einbent 41 5 often often RB cord-352796-6einbent 41 6 missing miss VBG cord-352796-6einbent 41 7 from from IN cord-352796-6einbent 41 8 slit slit NN cord-352796-6einbent 41 9 lamps lamp NNS cord-352796-6einbent 41 10 either either RB cord-352796-6einbent 41 11 because because IN cord-352796-6einbent 41 12 they -PRON- PRP cord-352796-6einbent 41 13 are be VBP cord-352796-6einbent 41 14 not not RB cord-352796-6einbent 41 15 fitted fit VBN cord-352796-6einbent 41 16 or or CC cord-352796-6einbent 41 17 because because IN cord-352796-6einbent 41 18 , , , cord-352796-6einbent 41 19 as as IN cord-352796-6einbent 41 20 they -PRON- PRP cord-352796-6einbent 41 21 get get VBP cord-352796-6einbent 41 22 in in IN cord-352796-6einbent 41 23 the the DT cord-352796-6einbent 41 24 way way NN cord-352796-6einbent 41 25 , , , cord-352796-6einbent 41 26 are be VBP cord-352796-6einbent 41 27 removed remove VBN cord-352796-6einbent 41 28 . . . cord-352796-6einbent 42 1 nares nares NNP cord-352796-6einbent 42 2 : : : cord-352796-6einbent 42 3 ( ( -LRB- cord-352796-6einbent 42 4 a a LS cord-352796-6einbent 42 5 ) ) -RRB- cord-352796-6einbent 42 6 , , , cord-352796-6einbent 42 7 average average JJ cord-352796-6einbent 42 8 total total JJ cord-352796-6einbent 42 9 eye eye NN cord-352796-6einbent 42 10 surface surface NN cord-352796-6einbent 42 11 exposed expose VBN cord-352796-6einbent 43 1 ; ; : cord-352796-6einbent 43 2 shaded shaded JJ cord-352796-6einbent 43 3 area area NN cord-352796-6einbent 43 4 represents represent VBZ cord-352796-6einbent 43 5 proportion proportion NN cord-352796-6einbent 43 6 of of IN cord-352796-6einbent 43 7 time time NN cord-352796-6einbent 43 8 not not RB cord-352796-6einbent 43 9 exposed expose VBN cord-352796-6einbent 43 10 , , , cord-352796-6einbent 43 11 due due IN cord-352796-6einbent 43 12 to to IN cord-352796-6einbent 43 13 winking winking NN cord-352796-6einbent 43 14 ; ; : cord-352796-6einbent 43 15 ( ( -LRB- cord-352796-6einbent 43 16 b b NN cord-352796-6einbent 43 17 ) ) -RRB- cord-352796-6einbent 43 18 , , , cord-352796-6einbent 43 19 average average JJ cord-352796-6einbent 43 20 total total JJ cord-352796-6einbent 43 21 mouth mouth NN cord-352796-6einbent 43 22 area area NN cord-352796-6einbent 43 23 exposed expose VBN cord-352796-6einbent 43 24 in in IN cord-352796-6einbent 43 25 talking talk VBG cord-352796-6einbent 43 26 ; ; : cord-352796-6einbent 43 27 shaded shaded JJ cord-352796-6einbent 43 28 area area NN cord-352796-6einbent 43 29 represents represent VBZ cord-352796-6einbent 43 30 proportion proportion NN cord-352796-6einbent 43 31 of of IN cord-352796-6einbent 43 32 time time NN cord-352796-6einbent 43 33 not not RB cord-352796-6einbent 43 34 exposed expose VBN cord-352796-6einbent 43 35 , , , cord-352796-6einbent 43 36 due due IN cord-352796-6einbent 43 37 to to IN cord-352796-6einbent 43 38 closure closure NN cord-352796-6einbent 43 39 ; ; : cord-352796-6einbent 43 40 ( ( -LRB- cord-352796-6einbent 43 41 c c NN cord-352796-6einbent 43 42 ) ) -RRB- cord-352796-6einbent 43 43 , , , cord-352796-6einbent 43 44 average average JJ cord-352796-6einbent 43 45 total total JJ cord-352796-6einbent 43 46 area area NN cord-352796-6einbent 43 47 of of IN cord-352796-6einbent 43 48 crosssection crosssection NN cord-352796-6einbent 43 49 of of IN cord-352796-6einbent 43 50 nares nares NNP cord-352796-6einbent 43 51 exposed expose VBN cord-352796-6einbent 43 52 ; ; : cord-352796-6einbent 43 53 shaded shaded JJ cord-352796-6einbent 43 54 area area NN cord-352796-6einbent 43 55 represents represent VBZ cord-352796-6einbent 43 56 proportion proportion NN cord-352796-6einbent 43 57 of of IN cord-352796-6einbent 43 58 time time NN cord-352796-6einbent 43 59 not not RB cord-352796-6einbent 43 60 exposed expose VBN cord-352796-6einbent 43 61 , , , cord-352796-6einbent 43 62 owing owe VBG cord-352796-6einbent 43 63 to to IN cord-352796-6einbent 43 64 protected protect VBN cord-352796-6einbent 43 65 position position NN cord-352796-6einbent 43 66 and and CC cord-352796-6einbent 43 67 expiration expiration NN cord-352796-6einbent 43 68 ( ( -LRB- cord-352796-6einbent 43 69 5 5 CD cord-352796-6einbent 43 70 ) ) -RRB- cord-352796-6einbent 43 71 . . . cord-352796-6einbent 44 1 That that DT cord-352796-6einbent 44 2 slit slit NN cord-352796-6einbent 44 3 lamps lamp NNS cord-352796-6einbent 44 4 and and CC cord-352796-6einbent 44 5 their -PRON- PRP$ cord-352796-6einbent 44 6 accessory accessory NN cord-352796-6einbent 44 7 lenses lense NNS cord-352796-6einbent 44 8 are be VBP cord-352796-6einbent 44 9 a a DT cord-352796-6einbent 44 10 source source NN cord-352796-6einbent 44 11 of of IN cord-352796-6einbent 44 12 infection infection NN cord-352796-6einbent 44 13 transmission transmission NN cord-352796-6einbent 44 14 has have VBZ cord-352796-6einbent 44 15 long long RB cord-352796-6einbent 44 16 been be VBN cord-352796-6einbent 44 17 known know VBN cord-352796-6einbent 44 18 ( ( -LRB- cord-352796-6einbent 44 19 15 15 CD cord-352796-6einbent 44 20 ) ) -RRB- cord-352796-6einbent 44 21 . . . cord-352796-6einbent 45 1 In in IN cord-352796-6einbent 45 2 epidemic epidemic JJ cord-352796-6einbent 45 3 adenoviral adenoviral NNP cord-352796-6einbent 45 4 keratoconjunctivitis keratoconjunctivitis NNP cord-352796-6einbent 45 5 ( ( -LRB- cord-352796-6einbent 45 6 ( ( -LRB- cord-352796-6einbent 45 7 AKC AKC NNP cord-352796-6einbent 45 8 ) ) -RRB- cord-352796-6einbent 45 9 , , , cord-352796-6einbent 45 10 shipyard shipyard NN cord-352796-6einbent 45 11 / / SYM cord-352796-6einbent 45 12 eye eye NN cord-352796-6einbent 45 13 hospital hospital NN cord-352796-6einbent 45 14 eye eye NN cord-352796-6einbent 45 15 ) ) -RRB- cord-352796-6einbent 45 16 ( ( -LRB- cord-352796-6einbent 45 17 10 10 CD cord-352796-6einbent 45 18 , , , cord-352796-6einbent 45 19 16 16 CD cord-352796-6einbent 45 20 ) ) -RRB- cord-352796-6einbent 45 21 , , , cord-352796-6einbent 45 22 ophthalmologists ophthalmologist NNS cord-352796-6einbent 45 23 are be VBP cord-352796-6einbent 45 24 not not RB cord-352796-6einbent 45 25 infrequently infrequently RB cord-352796-6einbent 45 26 infected infect VBN cord-352796-6einbent 45 27 although although IN cord-352796-6einbent 45 28 this this DT cord-352796-6einbent 45 29 is be VBZ cord-352796-6einbent 45 30 not not RB cord-352796-6einbent 45 31 well well RB cord-352796-6einbent 45 32 documented document VBN cord-352796-6einbent 45 33 ( ( -LRB- cord-352796-6einbent 45 34 17 17 CD cord-352796-6einbent 45 35 , , , cord-352796-6einbent 45 36 18 18 CD cord-352796-6einbent 45 37 ) ) -RRB- cord-352796-6einbent 45 38 . . . cord-352796-6einbent 46 1 While while IN cord-352796-6einbent 46 2 AKC AKC NNP cord-352796-6einbent 46 3 can can MD cord-352796-6einbent 46 4 cause cause VB cord-352796-6einbent 46 5 considerable considerable JJ cord-352796-6einbent 46 6 incapacity incapacity NN cord-352796-6einbent 46 7 and and CC cord-352796-6einbent 46 8 has have VBZ cord-352796-6einbent 46 9 resulted result VBN cord-352796-6einbent 46 10 in in IN cord-352796-6einbent 46 11 some some DT cord-352796-6einbent 46 12 riskminimization riskminimization NN cord-352796-6einbent 46 13 measures measure NNS cord-352796-6einbent 46 14 , , , cord-352796-6einbent 46 15 unlike unlike IN cord-352796-6einbent 46 16 coronavirus coronavirus NN cord-352796-6einbent 46 17 it -PRON- PRP cord-352796-6einbent 46 18 does do VBZ cord-352796-6einbent 46 19 not not RB cord-352796-6einbent 46 20 usually usually RB cord-352796-6einbent 46 21 result result VB cord-352796-6einbent 46 22 in in IN cord-352796-6einbent 46 23 death death NN cord-352796-6einbent 46 24 . . . cord-352796-6einbent 47 1 The the DT cord-352796-6einbent 47 2 earlier early RBR cord-352796-6einbent 47 3 severe severe JJ cord-352796-6einbent 47 4 acute acute JJ cord-352796-6einbent 47 5 respiratory respiratory JJ cord-352796-6einbent 47 6 syndrome syndrome NN cord-352796-6einbent 47 7 ( ( -LRB- cord-352796-6einbent 47 8 SARS SARS NNP cord-352796-6einbent 47 9 ) ) -RRB- cord-352796-6einbent 47 10 epidemic epidemic NN cord-352796-6einbent 47 11 resulted result VBD cord-352796-6einbent 47 12 in in IN cord-352796-6einbent 47 13 recommendations recommendation NNS cord-352796-6einbent 47 14 for for IN cord-352796-6einbent 47 15 how how WRB cord-352796-6einbent 47 16 to to TO cord-352796-6einbent 47 17 manage manage VB cord-352796-6einbent 47 18 eye eye NN cord-352796-6einbent 47 19 facilities facility NNS cord-352796-6einbent 47 20 and and CC cord-352796-6einbent 47 21 include include VBP cord-352796-6einbent 47 22 advice advice NN cord-352796-6einbent 47 23 in in IN cord-352796-6einbent 47 24 relation relation NN cord-352796-6einbent 47 25 to to IN cord-352796-6einbent 47 26 slit slit JJ cord-352796-6einbent 47 27 lamp lamp NN cord-352796-6einbent 47 28 cleaning cleaning NN cord-352796-6einbent 47 29 and and CC cord-352796-6einbent 47 30 eye eye NN cord-352796-6einbent 47 31 protection protection NN cord-352796-6einbent 47 32 for for IN cord-352796-6einbent 47 33 staff staff NN cord-352796-6einbent 47 34 ( ( -LRB- cord-352796-6einbent 47 35 19 19 CD cord-352796-6einbent 47 36 , , , cord-352796-6einbent 47 37 20 20 CD cord-352796-6einbent 47 38 ) ) -RRB- cord-352796-6einbent 47 39 . . . cord-352796-6einbent 48 1 Slit slit JJ cord-352796-6einbent 48 2 lamp lamp NN cord-352796-6einbent 48 3 biomicroscopy biomicroscopy NN cord-352796-6einbent 48 4 is be VBZ cord-352796-6einbent 48 5 an an DT cord-352796-6einbent 48 6 almost almost RB cord-352796-6einbent 48 7 optimal optimal JJ cord-352796-6einbent 48 8 method method NN cord-352796-6einbent 48 9 of of IN cord-352796-6einbent 48 10 transferring transfer VBG cord-352796-6einbent 48 11 material material NN cord-352796-6einbent 48 12 in in IN cord-352796-6einbent 48 13 breaths breath NNS cord-352796-6einbent 48 14 between between IN cord-352796-6einbent 48 15 two two CD cord-352796-6einbent 48 16 individuals individual NNS cord-352796-6einbent 48 17 , , , cord-352796-6einbent 48 18 short short JJ cord-352796-6einbent 48 19 of of IN cord-352796-6einbent 48 20 actual actual JJ cord-352796-6einbent 48 21 facial facial JJ cord-352796-6einbent 48 22 contact contact NN cord-352796-6einbent 48 23 . . . cord-352796-6einbent 49 1 A a DT cord-352796-6einbent 49 2 very very RB cord-352796-6einbent 49 3 recent recent JJ cord-352796-6einbent 49 4 study study NN cord-352796-6einbent 49 5 provides provide VBZ cord-352796-6einbent 49 6 evidence evidence NN cord-352796-6einbent 49 7 for for IN cord-352796-6einbent 49 8 human human NN cord-352796-6einbent 49 9 - - HYPH cord-352796-6einbent 49 10 to to IN cord-352796-6einbent 49 11 - - HYPH cord-352796-6einbent 49 12 human human JJ cord-352796-6einbent 49 13 transmission transmission NN cord-352796-6einbent 49 14 ( ( -LRB- cord-352796-6einbent 49 15 21 21 CD cord-352796-6einbent 49 16 ) ) -RRB- cord-352796-6einbent 49 17 . . . cord-352796-6einbent 50 1 Pathways pathway NNS cord-352796-6einbent 50 2 include include VBP cord-352796-6einbent 50 3 direct direct JJ cord-352796-6einbent 50 4 transmission transmission NN cord-352796-6einbent 50 5 , , , cord-352796-6einbent 50 6 such such JJ cord-352796-6einbent 50 7 as as IN cord-352796-6einbent 50 8 cough cough NN cord-352796-6einbent 50 9 , , , cord-352796-6einbent 50 10 sneeze sneeze VB cord-352796-6einbent 50 11 , , , cord-352796-6einbent 50 12 droplet droplet NN cord-352796-6einbent 50 13 inhalation inhalation NN cord-352796-6einbent 50 14 transmission transmission NN cord-352796-6einbent 50 15 as as RB cord-352796-6einbent 50 16 well well RB cord-352796-6einbent 50 17 as as IN cord-352796-6einbent 50 18 contact contact NN cord-352796-6einbent 50 19 transmission transmission NN cord-352796-6einbent 50 20 including include VBG cord-352796-6einbent 50 21 contact contact NN cord-352796-6einbent 50 22 with with IN cord-352796-6einbent 50 23 oral oral JJ cord-352796-6einbent 50 24 , , , cord-352796-6einbent 50 25 nasal nasal NN cord-352796-6einbent 50 26 , , , cord-352796-6einbent 50 27 and and CC cord-352796-6einbent 50 28 eye eye NN cord-352796-6einbent 50 29 mucous mucous JJ cord-352796-6einbent 50 30 membranes membrane NNS cord-352796-6einbent 50 31 ( ( -LRB- cord-352796-6einbent 50 32 22 22 CD cord-352796-6einbent 50 33 ) ) -RRB- cord-352796-6einbent 50 34 . . . cord-352796-6einbent 51 1 SARS SARS NNP cord-352796-6einbent 51 2 - - HYPH cord-352796-6einbent 51 3 CoV-2 CoV-2 NNP cord-352796-6einbent 51 4 aerosol aerosol NN cord-352796-6einbent 51 5 and and CC cord-352796-6einbent 51 6 fomite fomite NN cord-352796-6einbent 51 7 transmission transmission NN cord-352796-6einbent 51 8 is be VBZ cord-352796-6einbent 51 9 highly highly RB cord-352796-6einbent 51 10 likely likely JJ cord-352796-6einbent 51 11 , , , cord-352796-6einbent 51 12 since since IN cord-352796-6einbent 51 13 the the DT cord-352796-6einbent 51 14 virus virus NN cord-352796-6einbent 51 15 can can MD cord-352796-6einbent 51 16 remain remain VB cord-352796-6einbent 51 17 viable viable JJ cord-352796-6einbent 51 18 and and CC cord-352796-6einbent 51 19 infectious infectious JJ cord-352796-6einbent 51 20 in in IN cord-352796-6einbent 51 21 aerosols aerosol NNS cord-352796-6einbent 51 22 for for IN cord-352796-6einbent 51 23 hours hour NNS cord-352796-6einbent 51 24 and and CC cord-352796-6einbent 51 25 on on IN cord-352796-6einbent 51 26 different different JJ cord-352796-6einbent 51 27 surfaces surface NNS cord-352796-6einbent 51 28 up up RP cord-352796-6einbent 51 29 to to IN cord-352796-6einbent 51 30 days day NNS cord-352796-6einbent 51 31 ( ( -LRB- cord-352796-6einbent 51 32 23 23 CD cord-352796-6einbent 51 33 ) ) -RRB- cord-352796-6einbent 51 34 . . . cord-352796-6einbent 52 1 While while IN cord-352796-6einbent 52 2 transmission transmission NN cord-352796-6einbent 52 3 of of IN cord-352796-6einbent 52 4 coronaviruses coronaviruse NNS cord-352796-6einbent 52 5 occurs occur VBZ cord-352796-6einbent 52 6 via via IN cord-352796-6einbent 52 7 an an DT cord-352796-6einbent 52 8 airborne airborne JJ cord-352796-6einbent 52 9 route route NN cord-352796-6einbent 52 10 ( ( -LRB- cord-352796-6einbent 52 11 24 24 CD cord-352796-6einbent 52 12 ) ) -RRB- cord-352796-6einbent 52 13 , , , cord-352796-6einbent 52 14 because because IN cord-352796-6einbent 52 15 infected infected JJ cord-352796-6einbent 52 16 , , , cord-352796-6einbent 52 17 symptomatic symptomatic JJ cord-352796-6einbent 52 18 patients patient NNS cord-352796-6einbent 52 19 tend tend VBP cord-352796-6einbent 52 20 to to TO cord-352796-6einbent 52 21 develop develop VB cord-352796-6einbent 52 22 severe severe JJ cord-352796-6einbent 52 23 lower low JJR cord-352796-6einbent 52 24 , , , cord-352796-6einbent 52 25 as as IN cord-352796-6einbent 52 26 opposed oppose VBN cord-352796-6einbent 52 27 to to IN cord-352796-6einbent 52 28 upper upper JJ cord-352796-6einbent 52 29 respiratory respiratory JJ cord-352796-6einbent 52 30 tract tract NN cord-352796-6einbent 52 31 infections infection NNS cord-352796-6einbent 52 32 , , , cord-352796-6einbent 52 33 it -PRON- PRP cord-352796-6einbent 52 34 has have VBZ cord-352796-6einbent 52 35 been be VBN cord-352796-6einbent 52 36 supposed suppose VBN cord-352796-6einbent 52 37 that that IN cord-352796-6einbent 52 38 airborne airborne JJ cord-352796-6einbent 52 39 agent agent NN cord-352796-6einbent 52 40 virus virus NN cord-352796-6einbent 52 41 has have VBZ cord-352796-6einbent 52 42 to to TO cord-352796-6einbent 52 43 be be VB cord-352796-6einbent 52 44 small small JJ cord-352796-6einbent 52 45 enough enough RB cord-352796-6einbent 52 46 to to TO cord-352796-6einbent 52 47 penetrate penetrate VB cord-352796-6einbent 52 48 directly directly RB cord-352796-6einbent 52 49 into into IN cord-352796-6einbent 52 50 the the DT cord-352796-6einbent 52 51 lower low JJR cord-352796-6einbent 52 52 respiratory respiratory JJ cord-352796-6einbent 52 53 tract tract NN cord-352796-6einbent 52 54 to to TO cord-352796-6einbent 52 55 preferentially preferentially RB cord-352796-6einbent 52 56 replicate replicate VB cord-352796-6einbent 52 57 there there RB cord-352796-6einbent 52 58 before before IN cord-352796-6einbent 52 59 causing cause VBG cord-352796-6einbent 52 60 disease disease NN cord-352796-6einbent 52 61 . . . cord-352796-6einbent 53 1 That that DT cord-352796-6einbent 53 2 transmission transmission NN cord-352796-6einbent 53 3 could could MD cord-352796-6einbent 53 4 occur occur VB cord-352796-6einbent 53 5 via via IN cord-352796-6einbent 53 6 the the DT cord-352796-6einbent 53 7 ocular ocular JJ cord-352796-6einbent 53 8 - - HYPH cord-352796-6einbent 53 9 nasolacrimal nasolacrimal JJ cord-352796-6einbent 53 10 pathway pathway NN cord-352796-6einbent 53 11 was be VBD cord-352796-6einbent 53 12 not not RB cord-352796-6einbent 53 13 considered consider VBN cord-352796-6einbent 53 14 . . . cord-352796-6einbent 54 1 Human human JJ cord-352796-6einbent 54 2 eyes eye NNS cord-352796-6einbent 54 3 are be VBP cord-352796-6einbent 54 4 located locate VBN cord-352796-6einbent 54 5 at at IN cord-352796-6einbent 54 6 a a DT cord-352796-6einbent 54 7 coign coign NN cord-352796-6einbent 54 8 of of IN cord-352796-6einbent 54 9 vantage vantage NN cord-352796-6einbent 54 10 in in IN cord-352796-6einbent 54 11 the the DT cord-352796-6einbent 54 12 body body NN cord-352796-6einbent 54 13 , , , cord-352796-6einbent 54 14 simultaneously simultaneously RB cord-352796-6einbent 54 15 providing provide VBG cord-352796-6einbent 54 16 information information NN cord-352796-6einbent 54 17 from from IN cord-352796-6einbent 54 18 our -PRON- PRP$ cord-352796-6einbent 54 19 highest high JJS cord-352796-6einbent 54 20 band band NN cord-352796-6einbent 54 21 width width NN cord-352796-6einbent 54 22 sense sense NN cord-352796-6einbent 54 23 but but CC cord-352796-6einbent 54 24 also also RB cord-352796-6einbent 54 25 being be VBG cord-352796-6einbent 54 26 exposed expose VBN cord-352796-6einbent 54 27 to to IN cord-352796-6einbent 54 28 risk risk NN cord-352796-6einbent 54 29 of of IN cord-352796-6einbent 54 30 exposure exposure NN cord-352796-6einbent 54 31 including include VBG cord-352796-6einbent 54 32 to to IN cord-352796-6einbent 54 33 airborne airborne JJ cord-352796-6einbent 54 34 virus virus NN cord-352796-6einbent 54 35 . . . cord-352796-6einbent 55 1 The the DT cord-352796-6einbent 55 2 surface surface NN cord-352796-6einbent 55 3 area area NN cord-352796-6einbent 55 4 of of IN cord-352796-6einbent 55 5 the the DT cord-352796-6einbent 55 6 eye(s eye(s NN cord-352796-6einbent 55 7 ) ) -RRB- cord-352796-6einbent 55 8 is be VBZ cord-352796-6einbent 55 9 large large JJ cord-352796-6einbent 55 10 compared compare VBN cord-352796-6einbent 55 11 to to IN cord-352796-6einbent 55 12 that that DT cord-352796-6einbent 55 13 of of IN cord-352796-6einbent 55 14 the the DT cord-352796-6einbent 55 15 mouth mouth NN cord-352796-6einbent 55 16 and and CC cord-352796-6einbent 55 17 nares naris NNS cord-352796-6einbent 55 18 - - , cord-352796-6einbent 55 19 ( ( -LRB- cord-352796-6einbent 55 20 Figure Figure NNP cord-352796-6einbent 55 21 2D 2d NN cord-352796-6einbent 55 22 ) ) -RRB- cord-352796-6einbent 55 23 and and CC cord-352796-6einbent 55 24 was be VBD cord-352796-6einbent 55 25 recognized recognize VBN cord-352796-6einbent 55 26 early early RB cord-352796-6einbent 55 27 as as IN cord-352796-6einbent 55 28 a a DT cord-352796-6einbent 55 29 target target NN cord-352796-6einbent 55 30 for for IN cord-352796-6einbent 55 31 " " `` cord-352796-6einbent 55 32 promiscuous promiscuous JJ cord-352796-6einbent 55 33 spraying spraying NN cord-352796-6einbent 55 34 " " '' cord-352796-6einbent 56 1 whereby whereby WRB cord-352796-6einbent 56 2 coughing cough VBG cord-352796-6einbent 56 3 could could MD cord-352796-6einbent 56 4 project project VB cord-352796-6einbent 56 5 material material NN cord-352796-6einbent 56 6 at at IN cord-352796-6einbent 56 7 least least JJS cord-352796-6einbent 56 8 10 10 CD cord-352796-6einbent 56 9 feet foot NNS cord-352796-6einbent 56 10 away away RB cord-352796-6einbent 56 11 ( ( -LRB- cord-352796-6einbent 56 12 5 5 CD cord-352796-6einbent 56 13 ) ) -RRB- cord-352796-6einbent 56 14 . . . cord-352796-6einbent 57 1 Since since IN cord-352796-6einbent 57 2 this this DT cord-352796-6einbent 57 3 1919 1919 CD cord-352796-6einbent 57 4 study study NN cord-352796-6einbent 57 5 ( ( -LRB- cord-352796-6einbent 57 6 5 5 CD cord-352796-6einbent 57 7 ) ) -RRB- cord-352796-6einbent 57 8 , , , cord-352796-6einbent 57 9 a a DT cord-352796-6einbent 57 10 number number NN cord-352796-6einbent 57 11 of of IN cord-352796-6einbent 57 12 other other JJ cord-352796-6einbent 57 13 studies study NNS cord-352796-6einbent 57 14 have have VBP cord-352796-6einbent 57 15 investigated investigate VBN cord-352796-6einbent 57 16 ocular ocular JJ cord-352796-6einbent 57 17 surface surface NN cord-352796-6einbent 57 18 area area NN cord-352796-6einbent 57 19 and and CC cord-352796-6einbent 57 20 reported report VBD cord-352796-6einbent 57 21 as as IN cord-352796-6einbent 57 22 a a DT cord-352796-6einbent 57 23 total total NN cord-352796-6einbent 57 24 ( ( -LRB- cord-352796-6einbent 57 25 for for IN cord-352796-6einbent 57 26 two two CD cord-352796-6einbent 57 27 eyes eye NNS cord-352796-6einbent 57 28 ) ) -RRB- cord-352796-6einbent 57 29 as as IN cord-352796-6einbent 57 30 226 226 CD cord-352796-6einbent 57 31 - - SYM cord-352796-6einbent 57 32 426 426 CD cord-352796-6einbent 57 33 ( ( -LRB- cord-352796-6einbent 57 34 25 25 CD cord-352796-6einbent 57 35 ) ) -RRB- cord-352796-6einbent 57 36 and and CC cord-352796-6einbent 57 37 300 300 CD cord-352796-6einbent 57 38 - - SYM cord-352796-6einbent 57 39 640 640 CD cord-352796-6einbent 57 40 mm mm CD cord-352796-6einbent 57 41 2 2 CD cord-352796-6einbent 57 42 ( ( -LRB- cord-352796-6einbent 57 43 26 26 CD cord-352796-6einbent 57 44 ) ) -RRB- cord-352796-6einbent 57 45 , , , cord-352796-6einbent 57 46 indicating indicate VBG cord-352796-6einbent 57 47 that that IN cord-352796-6einbent 57 48 the the DT cord-352796-6einbent 57 49 figure figure NN cord-352796-6einbent 57 50 from from IN cord-352796-6einbent 57 51 Maxcy Maxcy NNP cord-352796-6einbent 57 52 's 's POS cord-352796-6einbent 57 53 early early JJ cord-352796-6einbent 57 54 study study NN cord-352796-6einbent 57 55 ( ( -LRB- cord-352796-6einbent 57 56 5 5 LS cord-352796-6einbent 57 57 ) ) -RRB- cord-352796-6einbent 57 58 was be VBD cord-352796-6einbent 57 59 a a DT cord-352796-6einbent 57 60 good good JJ cord-352796-6einbent 57 61 estimate estimate NN cord-352796-6einbent 57 62 ( ( -LRB- cord-352796-6einbent 57 63 Table table NN cord-352796-6einbent 57 64 1 1 CD cord-352796-6einbent 57 65 ) ) -RRB- cord-352796-6einbent 57 66 of of IN cord-352796-6einbent 57 67 the the DT cord-352796-6einbent 57 68 " " `` cord-352796-6einbent 57 69 visible visible JJ cord-352796-6einbent 57 70 " " '' cord-352796-6einbent 57 71 ocular ocular JJ cord-352796-6einbent 57 72 surface surface NN cord-352796-6einbent 57 73 . . . cord-352796-6einbent 58 1 The the DT cord-352796-6einbent 58 2 later later JJ cord-352796-6einbent 58 3 study study NN cord-352796-6einbent 58 4 ( ( -LRB- cord-352796-6einbent 58 5 26 26 CD cord-352796-6einbent 58 6 ) ) -RRB- cord-352796-6einbent 58 7 also also RB cord-352796-6einbent 58 8 explains explain VBZ cord-352796-6einbent 58 9 variability variability NN cord-352796-6einbent 58 10 in in IN cord-352796-6einbent 58 11 measurements measurement NNS cord-352796-6einbent 58 12 , , , cord-352796-6einbent 58 13 since since IN cord-352796-6einbent 58 14 palpebral palpebral JJ cord-352796-6einbent 58 15 aperture aperture NN cord-352796-6einbent 58 16 is be VBZ cord-352796-6einbent 58 17 dependent dependent JJ cord-352796-6einbent 58 18 on on IN cord-352796-6einbent 58 19 eye eye NN cord-352796-6einbent 58 20 gaze gaze NN cord-352796-6einbent 58 21 direction direction NN cord-352796-6einbent 58 22 . . . cord-352796-6einbent 59 1 However however RB cord-352796-6einbent 59 2 , , , cord-352796-6einbent 59 3 the the DT cord-352796-6einbent 59 4 total total JJ cord-352796-6einbent 59 5 ocular ocular JJ cord-352796-6einbent 59 6 surface surface NN cord-352796-6einbent 59 7 area area NN cord-352796-6einbent 59 8 has have VBZ cord-352796-6einbent 59 9 been be VBN cord-352796-6einbent 59 10 estimated estimate VBN cord-352796-6einbent 59 11 at at IN cord-352796-6einbent 59 12 ~ ~ CD cord-352796-6einbent 59 13 1600 1600 CD cord-352796-6einbent 60 1 -1869 -1869 NNP cord-352796-6einbent 60 2 sq sq NNP cord-352796-6einbent 60 3 . . . cord-352796-6einbent 61 1 mm mm NNP cord-352796-6einbent 61 2 / / SYM cord-352796-6einbent 61 3 eye eye NN cord-352796-6einbent 61 4 ( ( -LRB- cord-352796-6einbent 61 5 27 27 CD cord-352796-6einbent 61 6 , , , cord-352796-6einbent 61 7 28 28 CD cord-352796-6einbent 61 8 ) ) -RRB- cord-352796-6einbent 61 9 , , , cord-352796-6einbent 61 10 including include VBG cord-352796-6einbent 61 11 the the DT cord-352796-6einbent 61 12 cornea cornea NN cord-352796-6einbent 61 13 , , , cord-352796-6einbent 61 14 this this DT cord-352796-6einbent 61 15 representing represent VBG cord-352796-6einbent 61 16 a a DT cord-352796-6einbent 61 17 maximal maximal JJ cord-352796-6einbent 61 18 absorptive absorptive JJ cord-352796-6einbent 61 19 area area NN cord-352796-6einbent 61 20 of of IN cord-352796-6einbent 61 21 ~ ~ CD cord-352796-6einbent 61 22 3738 3738 CD cord-352796-6einbent 61 23 sq.mm sq.mm CD cord-352796-6einbent 61 24 , , , cord-352796-6einbent 61 25 accounting account VBG cord-352796-6einbent 61 26 for for IN cord-352796-6einbent 61 27 the the DT cord-352796-6einbent 61 28 tarsal tarsal NN cord-352796-6einbent 61 29 conjunctiva conjunctiva NN cord-352796-6einbent 61 30 and and CC cord-352796-6einbent 61 31 including include VBG cord-352796-6einbent 61 32 the the DT cord-352796-6einbent 61 33 palpebral palpebral JJ cord-352796-6einbent 61 34 fornices fornix NNS cord-352796-6einbent 61 35 . . . cord-352796-6einbent 62 1 Even even RB cord-352796-6einbent 62 2 this this DT cord-352796-6einbent 62 3 consideration consideration NN cord-352796-6einbent 62 4 underestimates underestimate VBZ cord-352796-6einbent 62 5 the the DT cord-352796-6einbent 62 6 potential potential JJ cord-352796-6einbent 62 7 ocular ocular JJ cord-352796-6einbent 62 8 / / SYM cord-352796-6einbent 62 9 periocular periocular NN cord-352796-6einbent 62 10 landing landing NN cord-352796-6einbent 62 11 zone zone NN cord-352796-6einbent 62 12 for for IN cord-352796-6einbent 62 13 a a DT cord-352796-6einbent 62 14 viral viral JJ cord-352796-6einbent 62 15 particle particle NN cord-352796-6einbent 62 16 . . . cord-352796-6einbent 63 1 It -PRON- PRP cord-352796-6einbent 63 2 is be VBZ cord-352796-6einbent 63 3 not not RB cord-352796-6einbent 63 4 an an DT cord-352796-6einbent 63 5 uncommon uncommon JJ cord-352796-6einbent 63 6 observation observation NN cord-352796-6einbent 63 7 that that IN cord-352796-6einbent 63 8 makeup makeup NN cord-352796-6einbent 63 9 , , , cord-352796-6einbent 63 10 applied apply VBD cord-352796-6einbent 63 11 around around IN cord-352796-6einbent 63 12 the the DT cord-352796-6einbent 63 13 eye eye NN cord-352796-6einbent 63 14 , , , cord-352796-6einbent 63 15 can can MD cord-352796-6einbent 63 16 " " `` cord-352796-6einbent 63 17 migrate migrate VB cord-352796-6einbent 63 18 " " '' cord-352796-6einbent 63 19 onto onto IN cord-352796-6einbent 63 20 the the DT cord-352796-6einbent 63 21 ocular ocular JJ cord-352796-6einbent 63 22 surface surface NN cord-352796-6einbent 63 23 ( ( -LRB- cord-352796-6einbent 63 24 29 29 CD cord-352796-6einbent 63 25 ) ) -RRB- cord-352796-6einbent 63 26 , , , cord-352796-6einbent 63 27 similar similar JJ cord-352796-6einbent 63 28 to to IN cord-352796-6einbent 63 29 the the DT cord-352796-6einbent 63 30 phenomenon phenomenon NN cord-352796-6einbent 63 31 by by IN cord-352796-6einbent 63 32 which which WDT cord-352796-6einbent 63 33 noxious noxious JJ cord-352796-6einbent 63 34 agents agent NNS cord-352796-6einbent 63 35 in in IN cord-352796-6einbent 63 36 minute minute NN cord-352796-6einbent 63 37 quantities quantity NNS cord-352796-6einbent 63 38 are be VBP cord-352796-6einbent 63 39 easily easily RB cord-352796-6einbent 63 40 transferred transfer VBN cord-352796-6einbent 63 41 from from IN cord-352796-6einbent 63 42 fingertip fingertip NN cord-352796-6einbent 63 43 to to IN cord-352796-6einbent 63 44 periocular periocular NN cord-352796-6einbent 63 45 skin skin NN cord-352796-6einbent 63 46 and and CC cord-352796-6einbent 63 47 then then RB cord-352796-6einbent 63 48 the the DT cord-352796-6einbent 63 49 eye eye NN cord-352796-6einbent 63 50 . . . cord-352796-6einbent 64 1 This this DT cord-352796-6einbent 64 2 may may MD cord-352796-6einbent 64 3 be be VB cord-352796-6einbent 64 4 due due JJ cord-352796-6einbent 64 5 to to IN cord-352796-6einbent 64 6 subtle subtle JJ cord-352796-6einbent 64 7 actions action NNS cord-352796-6einbent 64 8 of of IN cord-352796-6einbent 64 9 Riolan Riolan NNP cord-352796-6einbent 64 10 's 's POS cord-352796-6einbent 64 11 muscle muscle NN cord-352796-6einbent 64 12 ( ( -LRB- cord-352796-6einbent 64 13 30 30 CD cord-352796-6einbent 64 14 ) ) -RRB- cord-352796-6einbent 64 15 . . . cord-352796-6einbent 65 1 In in IN cord-352796-6einbent 65 2 fact fact NN cord-352796-6einbent 65 3 , , , cord-352796-6einbent 65 4 this this DT cord-352796-6einbent 65 5 mechanism mechanism NN cord-352796-6einbent 65 6 of of IN cord-352796-6einbent 65 7 transport transport NN cord-352796-6einbent 65 8 of of IN cord-352796-6einbent 65 9 agents agent NNS cord-352796-6einbent 65 10 from from IN cord-352796-6einbent 65 11 the the DT cord-352796-6einbent 65 12 periocular periocular NNP cord-352796-6einbent 65 13 eye eye NN cord-352796-6einbent 65 14 lid lid NN cord-352796-6einbent 65 15 skin skin NN cord-352796-6einbent 65 16 to to IN cord-352796-6einbent 65 17 the the DT cord-352796-6einbent 65 18 eye eye NN cord-352796-6einbent 65 19 ( ( -LRB- cord-352796-6einbent 65 20 obviating obviate VBG cord-352796-6einbent 65 21 the the DT cord-352796-6einbent 65 22 need need NN cord-352796-6einbent 65 23 for for IN cord-352796-6einbent 65 24 eyedrops eyedrop NNS cord-352796-6einbent 65 25 ) ) -RRB- cord-352796-6einbent 65 26 has have VBZ cord-352796-6einbent 65 27 been be VBN cord-352796-6einbent 65 28 termed term VBN cord-352796-6einbent 65 29 supracutaneous supracutaneous JJ cord-352796-6einbent 65 30 and and CC cord-352796-6einbent 65 31 has have VBZ cord-352796-6einbent 65 32 been be VBN cord-352796-6einbent 65 33 developed develop VBN cord-352796-6einbent 65 34 as as IN cord-352796-6einbent 65 35 an an DT cord-352796-6einbent 65 36 efficient efficient JJ cord-352796-6einbent 65 37 delivery delivery NN cord-352796-6einbent 65 38 system system NN cord-352796-6einbent 65 39 for for IN cord-352796-6einbent 65 40 management management NN cord-352796-6einbent 65 41 of of IN cord-352796-6einbent 65 42 dry dry JJ cord-352796-6einbent 65 43 eye eye NN cord-352796-6einbent 65 44 syndrome syndrome NN cord-352796-6einbent 65 45 ( ( -LRB- cord-352796-6einbent 65 46 31 31 CD cord-352796-6einbent 65 47 ) ) -RRB- cord-352796-6einbent 65 48 . . . cord-352796-6einbent 66 1 This this DT cord-352796-6einbent 66 2 supracutaneous supracutaneous JJ cord-352796-6einbent 66 3 mechanism mechanism NN cord-352796-6einbent 66 4 , , , cord-352796-6einbent 66 5 might may MD cord-352796-6einbent 66 6 provide provide VB cord-352796-6einbent 66 7 a a DT cord-352796-6einbent 66 8 substantial substantial JJ cord-352796-6einbent 66 9 periocular periocular NN cord-352796-6einbent 66 10 area area NN cord-352796-6einbent 66 11 in in IN cord-352796-6einbent 66 12 which which WDT cord-352796-6einbent 66 13 viral viral JJ cord-352796-6einbent 66 14 particles particle NNS cord-352796-6einbent 66 15 could could MD cord-352796-6einbent 66 16 land land VB cord-352796-6einbent 66 17 and and CC cord-352796-6einbent 66 18 be be VB cord-352796-6einbent 66 19 " " `` cord-352796-6einbent 66 20 funnelled funnel VBN cord-352796-6einbent 66 21 " " '' cord-352796-6einbent 66 22 onto onto IN cord-352796-6einbent 66 23 the the DT cord-352796-6einbent 66 24 ocular ocular JJ cord-352796-6einbent 66 25 surface surface NN cord-352796-6einbent 66 26 and and CC cord-352796-6einbent 66 27 beyond beyond IN cord-352796-6einbent 66 28 . . . cord-352796-6einbent 67 1 Table table NN cord-352796-6einbent 67 2 1 1 CD cord-352796-6einbent 67 3 provides provide VBZ cord-352796-6einbent 67 4 available available JJ cord-352796-6einbent 67 5 information information NN cord-352796-6einbent 67 6 on on IN cord-352796-6einbent 67 7 the the DT cord-352796-6einbent 67 8 size size NN cord-352796-6einbent 67 9 of of IN cord-352796-6einbent 67 10 the the DT cord-352796-6einbent 67 11 orbital orbital JJ cord-352796-6einbent 67 12 opening opening NN cord-352796-6einbent 67 13 ( ( -LRB- cord-352796-6einbent 67 14 32 32 CD cord-352796-6einbent 67 15 and and CC cord-352796-6einbent 67 16 reviewed review VBN cord-352796-6einbent 67 17 in in IN cord-352796-6einbent 67 18 33 33 CD cord-352796-6einbent 67 19 ) ) -RRB- cord-352796-6einbent 67 20 , , , cord-352796-6einbent 67 21 which which WDT cord-352796-6einbent 67 22 likely likely RB cord-352796-6einbent 67 23 underestimates underestimate VBZ cord-352796-6einbent 67 24 the the DT cord-352796-6einbent 67 25 area area NN cord-352796-6einbent 67 26 of of IN cord-352796-6einbent 67 27 eyelid eyelid NN cord-352796-6einbent 67 28 skin skin NN cord-352796-6einbent 67 29 . . . cord-352796-6einbent 68 1 We -PRON- PRP cord-352796-6einbent 68 2 have have VBP cord-352796-6einbent 68 3 estimated estimate VBN cord-352796-6einbent 68 4 eyelid eyelid NN cord-352796-6einbent 68 5 skin skin NN cord-352796-6einbent 68 6 to to TO cord-352796-6einbent 68 7 be be VB cord-352796-6einbent 68 8 ~ ~ NFP cord-352796-6einbent 68 9 4000 4000 CD cord-352796-6einbent 68 10 mm mm CD cord-352796-6einbent 68 11 2 2 CD cord-352796-6einbent 68 12 and and CC cord-352796-6einbent 68 13 that that DT cord-352796-6einbent 68 14 of of IN cord-352796-6einbent 68 15 the the DT cord-352796-6einbent 68 16 brow brow NN cord-352796-6einbent 68 17 to to TO cord-352796-6einbent 68 18 be be VB cord-352796-6einbent 68 19 ~ ~ NFP cord-352796-6einbent 68 20 3000 3000 CD cord-352796-6einbent 68 21 mm mm NN cord-352796-6einbent 68 22 2 2 CD cord-352796-6einbent 68 23 , , , cord-352796-6einbent 68 24 so so IN cord-352796-6einbent 68 25 that that IN cord-352796-6einbent 68 26 in in IN cord-352796-6einbent 68 27 total total NN cord-352796-6einbent 68 28 with with IN cord-352796-6einbent 68 29 the the DT cord-352796-6einbent 68 30 ocular ocular JJ cord-352796-6einbent 68 31 surface surface NN cord-352796-6einbent 68 32 area area NN cord-352796-6einbent 68 33 , , , cord-352796-6einbent 68 34 a a DT cord-352796-6einbent 68 35 landing landing NN cord-352796-6einbent 68 36 site site NN cord-352796-6einbent 68 37 of of IN cord-352796-6einbent 68 38 ~ ~ CD cord-352796-6einbent 68 39 10,000 10,000 CD cord-352796-6einbent 68 40 mm mm CD cord-352796-6einbent 68 41 2 2 CD cord-352796-6einbent 68 42 would would MD cord-352796-6einbent 68 43 be be VB cord-352796-6einbent 68 44 available available JJ cord-352796-6einbent 68 45 , , , cord-352796-6einbent 68 46 -2 -2 NN cord-352796-6einbent 68 47 orders order NNS cord-352796-6einbent 68 48 of of IN cord-352796-6einbent 68 49 magnitude magnitude NN cord-352796-6einbent 68 50 greater great JJR cord-352796-6einbent 68 51 than than IN cord-352796-6einbent 68 52 for for IN cord-352796-6einbent 68 53 the the DT cord-352796-6einbent 68 54 nares naris NNS cord-352796-6einbent 68 55 and and CC cord-352796-6einbent 68 56 mouth mouth NN cord-352796-6einbent 68 57 . . . cord-352796-6einbent 69 1 This this DT cord-352796-6einbent 69 2 does do VBZ cord-352796-6einbent 69 3 not not RB cord-352796-6einbent 69 4 take take VB cord-352796-6einbent 69 5 into into IN cord-352796-6einbent 69 6 account account NN cord-352796-6einbent 69 7 the the DT cord-352796-6einbent 69 8 surface surface NN cord-352796-6einbent 69 9 area area NN cord-352796-6einbent 69 10 that that WDT cord-352796-6einbent 69 11 could could MD cord-352796-6einbent 69 12 be be VB cord-352796-6einbent 69 13 attributed attribute VBN cord-352796-6einbent 69 14 to to IN cord-352796-6einbent 69 15 the the DT cord-352796-6einbent 69 16 hair hair NN cord-352796-6einbent 69 17 of of IN cord-352796-6einbent 69 18 the the DT cord-352796-6einbent 69 19 eyebrows eyebrow NNS cord-352796-6einbent 69 20 or or CC cord-352796-6einbent 69 21 the the DT cord-352796-6einbent 69 22 eyelashes eyelash NNS cord-352796-6einbent 69 23 , , , cord-352796-6einbent 69 24 for for IN cord-352796-6einbent 69 25 which which WDT cord-352796-6einbent 69 26 estimates estimate NNS cord-352796-6einbent 69 27 have have VBP cord-352796-6einbent 69 28 not not RB cord-352796-6einbent 69 29 been be VBN cord-352796-6einbent 69 30 made make VBN cord-352796-6einbent 69 31 . . . cord-352796-6einbent 70 1 Eyelash eyelash NN cord-352796-6einbent 70 2 aerodynamics aerodynamic NNS cord-352796-6einbent 70 3 may may MD cord-352796-6einbent 70 4 also also RB cord-352796-6einbent 70 5 play play VB cord-352796-6einbent 70 6 a a DT cord-352796-6einbent 70 7 role role NN cord-352796-6einbent 70 8 ( ( -LRB- cord-352796-6einbent 70 9 34 34 CD cord-352796-6einbent 70 10 ) ) -RRB- cord-352796-6einbent 70 11 . . . cord-352796-6einbent 71 1 Eyelashes eyelash NNS cord-352796-6einbent 71 2 have have VBP cord-352796-6einbent 71 3 been be VBN cord-352796-6einbent 71 4 shown show VBN cord-352796-6einbent 71 5 to to TO cord-352796-6einbent 71 6 divert divert VB cord-352796-6einbent 71 7 airflows airflow NNS cord-352796-6einbent 71 8 , , , cord-352796-6einbent 71 9 acting act VBG cord-352796-6einbent 71 10 as as IN cord-352796-6einbent 71 11 a a DT cord-352796-6einbent 71 12 passive passive JJ cord-352796-6einbent 71 13 ocular ocular JJ cord-352796-6einbent 71 14 dust dust NN cord-352796-6einbent 71 15 controlling control VBG cord-352796-6einbent 71 16 system system NN cord-352796-6einbent 71 17 . . . cord-352796-6einbent 72 1 They -PRON- PRP cord-352796-6einbent 72 2 reduce reduce VBP cord-352796-6einbent 72 3 evaporation evaporation NN cord-352796-6einbent 72 4 and and CC cord-352796-6einbent 72 5 particle particle NN cord-352796-6einbent 72 6 deposition deposition NN cord-352796-6einbent 72 7 up up IN cord-352796-6einbent 72 8 to to TO cord-352796-6einbent 72 9 50 50 CD cord-352796-6einbent 72 10 % % NN cord-352796-6einbent 72 11 . . . cord-352796-6einbent 73 1 In in IN cord-352796-6einbent 73 2 a a DT cord-352796-6einbent 73 3 comparative comparative JJ cord-352796-6einbent 73 4 study study NN cord-352796-6einbent 73 5 ( ( -LRB- cord-352796-6einbent 73 6 35 35 CD cord-352796-6einbent 73 7 ) ) -RRB- cord-352796-6einbent 73 8 , , , cord-352796-6einbent 73 9 Asian asian JJ cord-352796-6einbent 73 10 eyelashes eyelash NNS cord-352796-6einbent 73 11 had have VBD cord-352796-6einbent 73 12 lower low JJR cord-352796-6einbent 73 13 lift lift NN cord-352796-6einbent 73 14 - - HYPH cord-352796-6einbent 73 15 up up NN cord-352796-6einbent 73 16 and and CC cord-352796-6einbent 73 17 curl curl VB cord-352796-6einbent 73 18 - - HYPH cord-352796-6einbent 73 19 up up RP cord-352796-6einbent 73 20 angles angle NNS cord-352796-6einbent 73 21 , , , cord-352796-6einbent 73 22 fewer few JJR cord-352796-6einbent 73 23 numbers number NNS cord-352796-6einbent 73 24 and and CC cord-352796-6einbent 73 25 a a DT cord-352796-6einbent 73 26 thicker thick JJR cord-352796-6einbent 73 27 transverse transverse JJ cord-352796-6einbent 73 28 diameter diameter NN cord-352796-6einbent 73 29 as as IN cord-352796-6einbent 73 30 compared compare VBN cord-352796-6einbent 73 31 to to IN cord-352796-6einbent 73 32 Caucasian caucasian JJ cord-352796-6einbent 73 33 eyelashes eyelash NNS cord-352796-6einbent 73 34 . . . cord-352796-6einbent 74 1 Whether whether IN cord-352796-6einbent 74 2 these these DT cord-352796-6einbent 74 3 differences difference NNS cord-352796-6einbent 74 4 play play VBP cord-352796-6einbent 74 5 any any DT cord-352796-6einbent 74 6 role role NN cord-352796-6einbent 74 7 in in IN cord-352796-6einbent 74 8 influencing influence VBG cord-352796-6einbent 74 9 the the DT cord-352796-6einbent 74 10 rate rate NN cord-352796-6einbent 74 11 at at IN cord-352796-6einbent 74 12 which which WDT cord-352796-6einbent 74 13 particles particle VBZ cord-352796-6einbent 74 14 land land NN cord-352796-6einbent 74 15 on on IN cord-352796-6einbent 74 16 the the DT cord-352796-6einbent 74 17 ocular ocular JJ cord-352796-6einbent 74 18 surface surface NN cord-352796-6einbent 74 19 is be VBZ cord-352796-6einbent 74 20 unknown unknown JJ cord-352796-6einbent 74 21 . . . cord-352796-6einbent 75 1 However however RB cord-352796-6einbent 75 2 , , , cord-352796-6einbent 75 3 it -PRON- PRP cord-352796-6einbent 75 4 is be VBZ cord-352796-6einbent 75 5 possible possible JJ cord-352796-6einbent 75 6 that that IN cord-352796-6einbent 75 7 a a DT cord-352796-6einbent 75 8 deficiency deficiency NN cord-352796-6einbent 75 9 in in IN cord-352796-6einbent 75 10 this this DT cord-352796-6einbent 75 11 mechanism mechanism NN cord-352796-6einbent 75 12 could could MD cord-352796-6einbent 75 13 increase increase VB cord-352796-6einbent 75 14 the the DT cord-352796-6einbent 75 15 risk risk NN cord-352796-6einbent 75 16 of of IN cord-352796-6einbent 75 17 infection infection NN cord-352796-6einbent 75 18 . . . cord-352796-6einbent 76 1 In in IN cord-352796-6einbent 76 2 the the DT cord-352796-6einbent 76 3 1919 1919 CD cord-352796-6einbent 76 4 study study NN cord-352796-6einbent 76 5 ( ( -LRB- cord-352796-6einbent 76 6 5 5 CD cord-352796-6einbent 76 7 ) ) -RRB- cord-352796-6einbent 76 8 , , , cord-352796-6einbent 76 9 Bacillus Bacillus NNP cord-352796-6einbent 76 10 prodigiosus prodigiosus NNP cord-352796-6einbent 76 11 ( ( -LRB- cord-352796-6einbent 76 12 Serratia Serratia NNP cord-352796-6einbent 76 13 marcescens marcescen NNS cord-352796-6einbent 76 14 ) ) -RRB- cord-352796-6einbent 76 15 was be VBD cord-352796-6einbent 76 16 instilled instill VBN cord-352796-6einbent 76 17 into into IN cord-352796-6einbent 76 18 the the DT cord-352796-6einbent 76 19 lacrimal lacrimal JJ cord-352796-6einbent 76 20 sac sac NN cord-352796-6einbent 76 21 of of IN cord-352796-6einbent 76 22 5 5 CD cord-352796-6einbent 76 23 volunteers volunteer NNS cord-352796-6einbent 76 24 and and CC cord-352796-6einbent 76 25 subsequently subsequently RB cord-352796-6einbent 76 26 was be VBD cord-352796-6einbent 76 27 recoverable recoverable JJ cord-352796-6einbent 76 28 from from IN cord-352796-6einbent 76 29 the the DT cord-352796-6einbent 76 30 nose nose NN cord-352796-6einbent 76 31 , , , cord-352796-6einbent 76 32 throat throat NN cord-352796-6einbent 76 33 and and CC cord-352796-6einbent 76 34 stool stool NN cord-352796-6einbent 76 35 after after IN cord-352796-6einbent 76 36 5 5 CD cord-352796-6einbent 76 37 mins min NNS cord-352796-6einbent 76 38 , , , cord-352796-6einbent 76 39 15 15 CD cord-352796-6einbent 76 40 mins min NNS cord-352796-6einbent 76 41 and and CC cord-352796-6einbent 76 42 24 24 CD cord-352796-6einbent 76 43 hours hour NNS cord-352796-6einbent 76 44 respectively respectively RB cord-352796-6einbent 76 45 . . . cord-352796-6einbent 77 1 It -PRON- PRP cord-352796-6einbent 77 2 was be VBD cord-352796-6einbent 77 3 concluded conclude VBN cord-352796-6einbent 77 4 that that IN cord-352796-6einbent 77 5 via via IN cord-352796-6einbent 77 6 this this DT cord-352796-6einbent 77 7 ocular ocular JJ cord-352796-6einbent 77 8 lacrimatory lacrimatory NN cord-352796-6einbent 77 9 - - HYPH cord-352796-6einbent 77 10 nasal nasal NN cord-352796-6einbent 77 11 mechanism mechanism NN cord-352796-6einbent 77 12 ( ( -LRB- cord-352796-6einbent 77 13 Figures figure NNS cord-352796-6einbent 77 14 1 1 CD cord-352796-6einbent 77 15 and and CC cord-352796-6einbent 77 16 2 2 CD cord-352796-6einbent 77 17 ) ) -RRB- cord-352796-6einbent 77 18 , , , cord-352796-6einbent 77 19 the the DT cord-352796-6einbent 77 20 upper upper JJ cord-352796-6einbent 77 21 respiratory respiratory JJ cord-352796-6einbent 77 22 tract tract NN cord-352796-6einbent 77 23 of of IN cord-352796-6einbent 77 24 a a DT cord-352796-6einbent 77 25 person person NN cord-352796-6einbent 77 26 wearing wear VBG cord-352796-6einbent 77 27 a a DT cord-352796-6einbent 77 28 properly properly RB cord-352796-6einbent 77 29 constructed construct VBN cord-352796-6einbent 77 30 mask mask NN cord-352796-6einbent 77 31 may may MD cord-352796-6einbent 77 32 be be VB cord-352796-6einbent 77 33 infected infect VBN cord-352796-6einbent 77 34 by by IN cord-352796-6einbent 77 35 exposing expose VBG cord-352796-6einbent 77 36 the the DT cord-352796-6einbent 77 37 eye eye NN cord-352796-6einbent 77 38 briefly briefly NN cord-352796-6einbent 77 39 to to IN cord-352796-6einbent 77 40 direct direct JJ cord-352796-6einbent 77 41 droplet droplet NN cord-352796-6einbent 77 42 spray spray NN cord-352796-6einbent 77 43 . . . cord-352796-6einbent 78 1 Identification identification NN cord-352796-6einbent 78 2 of of IN cord-352796-6einbent 78 3 ocular ocular JJ cord-352796-6einbent 78 4 surface surface NN cord-352796-6einbent 78 5 cellular cellular JJ cord-352796-6einbent 78 6 receptors receptor NNS cord-352796-6einbent 78 7 utilized utilize VBN cord-352796-6einbent 78 8 by by IN cord-352796-6einbent 78 9 respiratory respiratory JJ cord-352796-6einbent 78 10 viruses virus NNS cord-352796-6einbent 78 11 has have VBZ cord-352796-6einbent 78 12 provided provide VBN cord-352796-6einbent 78 13 information information NN cord-352796-6einbent 78 14 as as IN cord-352796-6einbent 78 15 to to IN cord-352796-6einbent 78 16 the the DT cord-352796-6einbent 78 17 permissiveness permissiveness NN cord-352796-6einbent 78 18 of of IN cord-352796-6einbent 78 19 ocular ocular JJ cord-352796-6einbent 78 20 tissue tissue NN cord-352796-6einbent 78 21 to to IN cord-352796-6einbent 78 22 infection infection NN cord-352796-6einbent 78 23 with with IN cord-352796-6einbent 78 24 these these DT cord-352796-6einbent 78 25 agents agent NNS cord-352796-6einbent 78 26 ( ( -LRB- cord-352796-6einbent 78 27 6 6 CD cord-352796-6einbent 78 28 , , , cord-352796-6einbent 78 29 36 36 CD cord-352796-6einbent 78 30 ) ) -RRB- cord-352796-6einbent 78 31 . . . cord-352796-6einbent 79 1 Central central JJ cord-352796-6einbent 79 2 to to IN cord-352796-6einbent 79 3 COVID-19 covid-19 JJ cord-352796-6einbent 79 4 pathogenicity pathogenicity NN cord-352796-6einbent 79 5 is be VBZ cord-352796-6einbent 79 6 that that DT cord-352796-6einbent 79 7 cellular cellular JJ cord-352796-6einbent 79 8 entry entry NN cord-352796-6einbent 79 9 is be VBZ cord-352796-6einbent 79 10 via via IN cord-352796-6einbent 79 11 the the DT cord-352796-6einbent 79 12 cell cell NN cord-352796-6einbent 79 13 surface surface NN cord-352796-6einbent 79 14 angiotensin angiotensin NN cord-352796-6einbent 79 15 converting convert VBG cord-352796-6einbent 79 16 enzyme enzyme NN cord-352796-6einbent 79 17 2 2 CD cord-352796-6einbent 79 18 ( ( -LRB- cord-352796-6einbent 79 19 ACE2 ACE2 NNP cord-352796-6einbent 79 20 ) ) -RRB- cord-352796-6einbent 79 21 receptor receptor NN cord-352796-6einbent 79 22 ( ( -LRB- cord-352796-6einbent 79 23 37 37 CD cord-352796-6einbent 79 24 , , , cord-352796-6einbent 79 25 38 38 CD cord-352796-6einbent 79 26 ) ) -RRB- cord-352796-6einbent 79 27 . . . cord-352796-6einbent 80 1 It -PRON- PRP cord-352796-6einbent 80 2 is be VBZ cord-352796-6einbent 80 3 the the DT cord-352796-6einbent 80 4 only only JJ cord-352796-6einbent 80 5 mammalian mammalian JJ cord-352796-6einbent 80 6 group group NN cord-352796-6einbent 80 7 I -PRON- PRP cord-352796-6einbent 80 8 coronavirus coronavirus VBP cord-352796-6einbent 80 9 known know VBN cord-352796-6einbent 80 10 to to TO cord-352796-6einbent 80 11 use use VB cord-352796-6einbent 80 12 ACE2 ACE2 NNP cord-352796-6einbent 80 13 as as IN cord-352796-6einbent 80 14 its -PRON- PRP$ cord-352796-6einbent 80 15 receptor receptor NN cord-352796-6einbent 80 16 ( ( -LRB- cord-352796-6einbent 80 17 39 39 CD cord-352796-6einbent 80 18 ) ) -RRB- cord-352796-6einbent 80 19 . . . cord-352796-6einbent 81 1 ACE2 ACE2 NNP cord-352796-6einbent 81 2 was be VBD cord-352796-6einbent 81 3 previously previously RB cord-352796-6einbent 81 4 identified identify VBN cord-352796-6einbent 81 5 as as IN cord-352796-6einbent 81 6 the the DT cord-352796-6einbent 81 7 receptor receptor NN cord-352796-6einbent 81 8 for for IN cord-352796-6einbent 81 9 SARS SARS NNP cord-352796-6einbent 81 10 - - HYPH cord-352796-6einbent 81 11 Cov Cov NNP cord-352796-6einbent 81 12 and and CC cord-352796-6einbent 81 13 NL63 NL63 NNP cord-352796-6einbent 81 14 ( ( -LRB- cord-352796-6einbent 81 15 40 40 CD cord-352796-6einbent 81 16 ) ) -RRB- cord-352796-6einbent 81 17 . . . cord-352796-6einbent 82 1 Virus virus NN cord-352796-6einbent 82 2 infectivity infectivity NN cord-352796-6einbent 82 3 studies study NNS cord-352796-6einbent 82 4 have have VBP cord-352796-6einbent 82 5 shown show VBN cord-352796-6einbent 82 6 that that IN cord-352796-6einbent 82 7 ACE2 ACE2 NNP cord-352796-6einbent 82 8 is be VBZ cord-352796-6einbent 82 9 essential essential JJ cord-352796-6einbent 82 10 for for IN cord-352796-6einbent 82 11 SARS SARS NNP cord-352796-6einbent 82 12 - - HYPH cord-352796-6einbent 82 13 CoV-2 CoV-2 NNP cord-352796-6einbent 82 14 to to TO cord-352796-6einbent 82 15 enter enter VB cord-352796-6einbent 82 16 HeLa HeLa NNP cord-352796-6einbent 82 17 cells cell NNS cord-352796-6einbent 82 18 ( ( -LRB- cord-352796-6einbent 82 19 41 41 CD cord-352796-6einbent 82 20 ) ) -RRB- cord-352796-6einbent 82 21 . . . cord-352796-6einbent 83 1 While while IN cord-352796-6einbent 83 2 ACE2 ACE2 NNP cord-352796-6einbent 83 3 mRNA mRNA NNP cord-352796-6einbent 83 4 is be VBZ cord-352796-6einbent 83 5 known know VBN cord-352796-6einbent 83 6 to to TO cord-352796-6einbent 83 7 be be VB cord-352796-6einbent 83 8 present present JJ cord-352796-6einbent 83 9 in in IN cord-352796-6einbent 83 10 virtually virtually RB cord-352796-6einbent 83 11 all all DT cord-352796-6einbent 83 12 organs organ NNS cord-352796-6einbent 83 13 , , , cord-352796-6einbent 83 14 surface surface NN cord-352796-6einbent 83 15 expression expression NN cord-352796-6einbent 83 16 of of IN cord-352796-6einbent 83 17 ACE2 ACE2 NNP cord-352796-6einbent 83 18 protein protein NN cord-352796-6einbent 83 19 was be VBD cord-352796-6einbent 83 20 described describe VBN cord-352796-6einbent 83 21 in in IN cord-352796-6einbent 83 22 lung lung NN cord-352796-6einbent 83 23 alveolar alveolar NN cord-352796-6einbent 83 24 epithelial epithelial JJ cord-352796-6einbent 83 25 cells cell NNS cord-352796-6einbent 83 26 and and CC cord-352796-6einbent 83 27 small small JJ cord-352796-6einbent 83 28 intestinal intestinal JJ cord-352796-6einbent 83 29 enterocytes enterocyte NNS cord-352796-6einbent 83 30 ( ( -LRB- cord-352796-6einbent 83 31 42 42 CD cord-352796-6einbent 83 32 ) ) -RRB- cord-352796-6einbent 83 33 and and CC cord-352796-6einbent 83 34 it -PRON- PRP cord-352796-6einbent 83 35 was be VBD cord-352796-6einbent 83 36 postulated postulate VBN cord-352796-6einbent 83 37 that that IN cord-352796-6einbent 83 38 ACE2 ACE2 NNP cord-352796-6einbent 83 39 might may MD cord-352796-6einbent 83 40 provide provide VB cord-352796-6einbent 83 41 the the DT cord-352796-6einbent 83 42 coronavirus coronavirus NN cord-352796-6einbent 83 43 entry entry NN cord-352796-6einbent 83 44 route route NN cord-352796-6einbent 83 45 . . . cord-352796-6einbent 84 1 The the DT cord-352796-6einbent 84 2 eye eye NN cord-352796-6einbent 84 3 and and CC cord-352796-6einbent 84 4 its -PRON- PRP$ cord-352796-6einbent 84 5 adnexae adnexae NN cord-352796-6einbent 84 6 were be VBD cord-352796-6einbent 84 7 not not RB cord-352796-6einbent 84 8 investigated investigate VBN cord-352796-6einbent 84 9 in in IN cord-352796-6einbent 84 10 this this DT cord-352796-6einbent 84 11 study study NN cord-352796-6einbent 84 12 . . . cord-352796-6einbent 85 1 It -PRON- PRP cord-352796-6einbent 85 2 was be VBD cord-352796-6einbent 85 3 subsequently subsequently RB cord-352796-6einbent 85 4 shown show VBN cord-352796-6einbent 85 5 that that IN cord-352796-6einbent 85 6 ACE2 ACE2 NNP cord-352796-6einbent 85 7 protein protein NN cord-352796-6einbent 85 8 is be VBZ cord-352796-6einbent 85 9 more more RBR cord-352796-6einbent 85 10 abundantly abundantly RB cord-352796-6einbent 85 11 expressed express VBN cord-352796-6einbent 85 12 on on IN cord-352796-6einbent 85 13 the the DT cord-352796-6einbent 85 14 apical apical JJ cord-352796-6einbent 85 15 than than IN cord-352796-6einbent 85 16 the the DT cord-352796-6einbent 85 17 basolateral basolateral JJ cord-352796-6einbent 85 18 surface surface NN cord-352796-6einbent 85 19 of of IN cord-352796-6einbent 85 20 polarized polarized JJ cord-352796-6einbent 85 21 airway airway NN cord-352796-6einbent 85 22 epithelia epithelium NNS cord-352796-6einbent 85 23 ( ( -LRB- cord-352796-6einbent 85 24 43 43 CD cord-352796-6einbent 85 25 ) ) -RRB- cord-352796-6einbent 85 26 and and CC cord-352796-6einbent 85 27 thus thus RB cord-352796-6einbent 85 28 accessible accessible JJ cord-352796-6einbent 85 29 by by IN cord-352796-6einbent 85 30 topical topical JJ cord-352796-6einbent 85 31 agents agent NNS cord-352796-6einbent 85 32 . . . cord-352796-6einbent 86 1 An an DT cord-352796-6einbent 86 2 immunohistochemical immunohistochemical JJ cord-352796-6einbent 86 3 study study NN cord-352796-6einbent 86 4 revealed reveal VBD cord-352796-6einbent 86 5 both both DT cord-352796-6einbent 86 6 extra extra JJ cord-352796-6einbent 86 7 - - HYPH cord-352796-6einbent 86 8 and and CC cord-352796-6einbent 86 9 intraocular intraocular JJ cord-352796-6einbent 86 10 localisation localisation NN cord-352796-6einbent 86 11 of of IN cord-352796-6einbent 86 12 ACE ACE NNP cord-352796-6einbent 86 13 in in IN cord-352796-6einbent 86 14 human human JJ cord-352796-6einbent 86 15 eyes eye NNS cord-352796-6einbent 86 16 ( ( -LRB- cord-352796-6einbent 86 17 44 44 CD cord-352796-6einbent 86 18 ) ) -RRB- cord-352796-6einbent 86 19 . . . cord-352796-6einbent 87 1 Of of IN cord-352796-6einbent 87 2 particular particular JJ cord-352796-6einbent 87 3 interest interest NN cord-352796-6einbent 87 4 was be VBD cord-352796-6einbent 87 5 the the DT cord-352796-6einbent 87 6 localisation localisation NN cord-352796-6einbent 87 7 of of IN cord-352796-6einbent 87 8 ACE ACE NNP cord-352796-6einbent 87 9 to to IN cord-352796-6einbent 87 10 the the DT cord-352796-6einbent 87 11 epithelial epithelial JJ cord-352796-6einbent 87 12 cells cell NNS cord-352796-6einbent 87 13 of of IN cord-352796-6einbent 87 14 both both CC cord-352796-6einbent 87 15 the the DT cord-352796-6einbent 87 16 cornea cornea NN cord-352796-6einbent 87 17 and and CC cord-352796-6einbent 87 18 conjunctiva conjunctiva NN cord-352796-6einbent 87 19 . . . cord-352796-6einbent 88 1 Apical Apical NNP cord-352796-6einbent 88 2 epithelia epithelia NN cord-352796-6einbent 88 3 location location NN cord-352796-6einbent 88 4 and and CC cord-352796-6einbent 88 5 whether whether IN cord-352796-6einbent 88 6 receptors receptor NNS cord-352796-6einbent 88 7 are be VBP cord-352796-6einbent 88 8 ACE2 ACE2 NNP cord-352796-6einbent 88 9 remains remain VBZ cord-352796-6einbent 88 10 to to TO cord-352796-6einbent 88 11 be be VB cord-352796-6einbent 88 12 confirmed confirm VBN cord-352796-6einbent 88 13 . . . cord-352796-6einbent 89 1 Recently recently RB cord-352796-6einbent 89 2 , , , cord-352796-6einbent 89 3 more more RBR cord-352796-6einbent 89 4 widespread widespread JJ cord-352796-6einbent 89 5 distribution distribution NN cord-352796-6einbent 89 6 of of IN cord-352796-6einbent 89 7 SARS SARS NNP cord-352796-6einbent 89 8 - - HYPH cord-352796-6einbent 89 9 CoV-2 CoV-2 NNP cord-352796-6einbent 89 10 entry entry NN cord-352796-6einbent 89 11 factors factor NNS cord-352796-6einbent 89 12 , , , cord-352796-6einbent 89 13 ACE2 ACE2 NNP cord-352796-6einbent 89 14 as as RB cord-352796-6einbent 89 15 well well RB cord-352796-6einbent 89 16 as as IN cord-352796-6einbent 89 17 TMPRSS2 TMPRSS2 NNP cord-352796-6einbent 89 18 protease protease NN cord-352796-6einbent 89 19 and and CC cord-352796-6einbent 89 20 cathepsin cathepsin NN cord-352796-6einbent 89 21 B B NNP cord-352796-6einbent 89 22 / / SYM cord-352796-6einbent 89 23 L l NN cord-352796-6einbent 89 24 activity activity NN cord-352796-6einbent 89 25 ( ( -LRB- cord-352796-6einbent 89 26 for for IN cord-352796-6einbent 89 27 post post JJ cord-352796-6einbent 89 28 - - JJ cord-352796-6einbent 89 29 binding binding JJ cord-352796-6einbent 89 30 spike spike NN cord-352796-6einbent 89 31 protein protein NN cord-352796-6einbent 89 32 priming priming NN cord-352796-6einbent 89 33 ) ) -RRB- cord-352796-6einbent 89 34 have have VBP cord-352796-6einbent 89 35 been be VBN cord-352796-6einbent 89 36 documented document VBN cord-352796-6einbent 89 37 using use VBG cord-352796-6einbent 89 38 single single JJ cord-352796-6einbent 89 39 - - HYPH cord-352796-6einbent 89 40 cell cell NN cord-352796-6einbent 89 41 RNA rna NN cord-352796-6einbent 89 42 - - HYPH cord-352796-6einbent 89 43 sequencing sequence VBG cord-352796-6einbent 89 44 data datum NNS cord-352796-6einbent 89 45 ( ( -LRB- cord-352796-6einbent 89 46 45 45 CD cord-352796-6einbent 89 47 ) ) -RRB- cord-352796-6einbent 89 48 . . . cord-352796-6einbent 90 1 While while IN cord-352796-6einbent 90 2 it -PRON- PRP cord-352796-6einbent 90 3 was be VBD cord-352796-6einbent 90 4 recognized recognize VBN cord-352796-6einbent 90 5 that that IN cord-352796-6einbent 90 6 binding bind VBG cord-352796-6einbent 90 7 affinity affinity NN cord-352796-6einbent 90 8 of of IN cord-352796-6einbent 90 9 the the DT cord-352796-6einbent 90 10 spike spike NN cord-352796-6einbent 90 11 protein protein NN cord-352796-6einbent 90 12 and and CC cord-352796-6einbent 90 13 ACE2 ACE2 NNP cord-352796-6einbent 90 14 is be VBZ cord-352796-6einbent 90 15 the the DT cord-352796-6einbent 90 16 major major JJ cord-352796-6einbent 90 17 determinant determinant NN cord-352796-6einbent 90 18 of of IN cord-352796-6einbent 90 19 SARS SARS NNP cord-352796-6einbent 90 20 - - HYPH cord-352796-6einbent 90 21 CoV cov NN cord-352796-6einbent 90 22 replication replication NN cord-352796-6einbent 90 23 rate rate NN cord-352796-6einbent 90 24 and and CC cord-352796-6einbent 90 25 disease disease NN cord-352796-6einbent 90 26 severity severity NN cord-352796-6einbent 90 27 and and CC cord-352796-6einbent 90 28 that that IN cord-352796-6einbent 90 29 viral viral JJ cord-352796-6einbent 90 30 entry entry NN cord-352796-6einbent 90 31 also also RB cord-352796-6einbent 90 32 depends depend VBZ cord-352796-6einbent 90 33 on on IN cord-352796-6einbent 90 34 protease protease NN cord-352796-6einbent 90 35 activity activity NN cord-352796-6einbent 90 36 , , , cord-352796-6einbent 90 37 ACE2 ACE2 NNP cord-352796-6einbent 90 38 , , , cord-352796-6einbent 90 39 rather rather RB cord-352796-6einbent 90 40 than than IN cord-352796-6einbent 90 41 protease protease NN cord-352796-6einbent 90 42 activity activity NN cord-352796-6einbent 90 43 , , , cord-352796-6einbent 90 44 may may MD cord-352796-6einbent 90 45 be be VB cord-352796-6einbent 90 46 a a DT cord-352796-6einbent 90 47 limiting limit VBG cord-352796-6einbent 90 48 factor factor NN cord-352796-6einbent 90 49 for for IN cord-352796-6einbent 90 50 initial initial JJ cord-352796-6einbent 90 51 viral viral JJ cord-352796-6einbent 90 52 entry entry NN cord-352796-6einbent 90 53 . . . cord-352796-6einbent 91 1 This this DT cord-352796-6einbent 91 2 study study NN cord-352796-6einbent 91 3 confirmed confirm VBD cord-352796-6einbent 91 4 evidence evidence NN cord-352796-6einbent 91 5 of of IN cord-352796-6einbent 91 6 ACE2 ACE2 NNP cord-352796-6einbent 91 7 in in IN cord-352796-6einbent 91 8 the the DT cord-352796-6einbent 91 9 limbus limbus NN cord-352796-6einbent 91 10 , , , cord-352796-6einbent 91 11 corneal corneal JJ cord-352796-6einbent 91 12 epithelium epithelium NN cord-352796-6einbent 91 13 ( ( -LRB- cord-352796-6einbent 91 14 basal basal NN cord-352796-6einbent 91 15 / / SYM cord-352796-6einbent 91 16 suprabasal suprabasal NN cord-352796-6einbent 91 17 , , , cord-352796-6einbent 91 18 superficial superficial JJ cord-352796-6einbent 91 19 and and CC cord-352796-6einbent 91 20 wing wing NN cord-352796-6einbent 91 21 cells cell NNS cord-352796-6einbent 91 22 ) ) -RRB- cord-352796-6einbent 91 23 and and CC cord-352796-6einbent 91 24 conjunctiva conjunctiva NN cord-352796-6einbent 91 25 ( ( -LRB- cord-352796-6einbent 91 26 basal basal JJ cord-352796-6einbent 91 27 and and CC cord-352796-6einbent 91 28 superficial superficial JJ cord-352796-6einbent 91 29 cells cell NNS cord-352796-6einbent 91 30 ) ) -RRB- cord-352796-6einbent 91 31 and and CC cord-352796-6einbent 91 32 co co NN cord-352796-6einbent 91 33 - - NN cord-352796-6einbent 91 34 location location NN cord-352796-6einbent 91 35 with with IN cord-352796-6einbent 91 36 TMPRSS2 TMPRSS2 NNP cord-352796-6einbent 91 37 in in IN cord-352796-6einbent 91 38 superficial superficial JJ cord-352796-6einbent 91 39 conjunctival conjunctival NN cord-352796-6einbent 91 40 cells cell NNS cord-352796-6einbent 91 41 . . . cord-352796-6einbent 92 1 Of of IN cord-352796-6einbent 92 2 interest interest NN cord-352796-6einbent 92 3 is be VBZ cord-352796-6einbent 92 4 that that IN cord-352796-6einbent 92 5 this this DT cord-352796-6einbent 92 6 study study NN cord-352796-6einbent 92 7 demonstrated demonstrate VBD cord-352796-6einbent 92 8 evidence evidence NN cord-352796-6einbent 92 9 of of IN cord-352796-6einbent 92 10 ACE2 ACE2 NNP cord-352796-6einbent 92 11 in in IN cord-352796-6einbent 92 12 nasal nasal JJ cord-352796-6einbent 92 13 goblet goblet NN cord-352796-6einbent 92 14 cells cell NNS cord-352796-6einbent 92 15 which which WDT cord-352796-6einbent 92 16 also also RB cord-352796-6einbent 92 17 express express VBP cord-352796-6einbent 92 18 genes gene NNS cord-352796-6einbent 92 19 associated associate VBN cord-352796-6einbent 92 20 with with IN cord-352796-6einbent 92 21 immune immune JJ cord-352796-6einbent 92 22 functions function NNS cord-352796-6einbent 92 23 including include VBG cord-352796-6einbent 92 24 innate innate JJ cord-352796-6einbent 92 25 and and CC cord-352796-6einbent 92 26 antiviral antiviral JJ cord-352796-6einbent 92 27 immune immune JJ cord-352796-6einbent 92 28 functions function NNS cord-352796-6einbent 92 29 . . . cord-352796-6einbent 93 1 There there EX cord-352796-6einbent 93 2 should should MD cord-352796-6einbent 93 3 be be VB cord-352796-6einbent 93 4 some some DT cord-352796-6einbent 93 5 priority priority NN cord-352796-6einbent 93 6 for for IN cord-352796-6einbent 93 7 re re NN cord-352796-6einbent 93 8 - - NN cord-352796-6einbent 93 9 evaluation evaluation NN cord-352796-6einbent 93 10 of of IN cord-352796-6einbent 93 11 these these DT cord-352796-6einbent 93 12 elements element NNS cord-352796-6einbent 93 13 in in IN cord-352796-6einbent 93 14 the the DT cord-352796-6einbent 93 15 ocular ocular JJ cord-352796-6einbent 93 16 surface surface NN cord-352796-6einbent 93 17 ( ( -LRB- cord-352796-6einbent 93 18 46 46 CD cord-352796-6einbent 93 19 ) ) -RRB- cord-352796-6einbent 93 20 . . . cord-352796-6einbent 94 1 The the DT cord-352796-6einbent 94 2 density density NN cord-352796-6einbent 94 3 of of IN cord-352796-6einbent 94 4 SARS SARS NNP cord-352796-6einbent 94 5 - - HYPH cord-352796-6einbent 94 6 CoV-2 CoV-2 NNP cord-352796-6einbent 94 7 entry entry NN cord-352796-6einbent 94 8 factors factor NNS cord-352796-6einbent 94 9 and and CC cord-352796-6einbent 94 10 their -PRON- PRP$ cord-352796-6einbent 94 11 presence presence NN cord-352796-6einbent 94 12 or or CC cord-352796-6einbent 94 13 absence absence NN cord-352796-6einbent 94 14 in in IN cord-352796-6einbent 94 15 the the DT cord-352796-6einbent 94 16 lacrimal lacrimal JJ cord-352796-6einbent 94 17 drainage drainage NN cord-352796-6einbent 94 18 system system NN cord-352796-6einbent 94 19 would would MD cord-352796-6einbent 94 20 be be VB cord-352796-6einbent 94 21 of of IN cord-352796-6einbent 94 22 interest interest NN cord-352796-6einbent 94 23 , , , cord-352796-6einbent 94 24 since since IN cord-352796-6einbent 94 25 viral viral JJ cord-352796-6einbent 94 26 particles particle NNS cord-352796-6einbent 94 27 that that WDT cord-352796-6einbent 94 28 land land VBP cord-352796-6einbent 94 29 in in IN cord-352796-6einbent 94 30 the the DT cord-352796-6einbent 94 31 tear tear JJ cord-352796-6einbent 94 32 film film NN cord-352796-6einbent 94 33 need need VBP cord-352796-6einbent 94 34 not not RB cord-352796-6einbent 94 35 necessarily necessarily RB cord-352796-6einbent 94 36 bind bind VB cord-352796-6einbent 94 37 to to IN cord-352796-6einbent 94 38 an an DT cord-352796-6einbent 94 39 epithelial epithelial JJ cord-352796-6einbent 94 40 cell cell NN cord-352796-6einbent 94 41 immediately immediately RB cord-352796-6einbent 94 42 but but CC cord-352796-6einbent 94 43 could could MD cord-352796-6einbent 94 44 be be VB cord-352796-6einbent 94 45 presented present VBN cord-352796-6einbent 94 46 with with IN cord-352796-6einbent 94 47 a a DT cord-352796-6einbent 94 48 second second JJ cord-352796-6einbent 94 49 opportunity opportunity NN cord-352796-6einbent 94 50 ( ( -LRB- cord-352796-6einbent 94 51 a a DT cord-352796-6einbent 94 52 " " `` cord-352796-6einbent 94 53 wash wash VB cord-352796-6einbent 94 54 through through IN cord-352796-6einbent 94 55 " " `` cord-352796-6einbent 94 56 effect effect NN cord-352796-6einbent 94 57 ) ) -RRB- cord-352796-6einbent 94 58 in in IN cord-352796-6einbent 94 59 the the DT cord-352796-6einbent 94 60 lacrimal lacrimal JJ cord-352796-6einbent 94 61 drainage drainage NN cord-352796-6einbent 94 62 system system NN cord-352796-6einbent 94 63 . . . cord-352796-6einbent 95 1 Tear tear JJ cord-352796-6einbent 95 2 film film NN cord-352796-6einbent 95 3 resilience resilience NN cord-352796-6einbent 95 4 may may MD cord-352796-6einbent 95 5 well well RB cord-352796-6einbent 95 6 protect protect VB cord-352796-6einbent 95 7 the the DT cord-352796-6einbent 95 8 underlying underlie VBG cord-352796-6einbent 95 9 corneal corneal NN cord-352796-6einbent 95 10 and and CC cord-352796-6einbent 95 11 conjunctival conjunctival JJ cord-352796-6einbent 95 12 epithelium epithelium NN cord-352796-6einbent 95 13 so so IN cord-352796-6einbent 95 14 that that IN cord-352796-6einbent 95 15 viral viral JJ cord-352796-6einbent 95 16 adherence adherence NN cord-352796-6einbent 95 17 to to IN cord-352796-6einbent 95 18 the the DT cord-352796-6einbent 95 19 tear tear JJ cord-352796-6einbent 95 20 film film NN cord-352796-6einbent 95 21 could could MD cord-352796-6einbent 95 22 prevent prevent VB cord-352796-6einbent 95 23 access access NN cord-352796-6einbent 95 24 to to IN cord-352796-6einbent 95 25 the the DT cord-352796-6einbent 95 26 apical apical JJ cord-352796-6einbent 95 27 epithelial epithelial JJ cord-352796-6einbent 95 28 surface surface NN cord-352796-6einbent 95 29 , , , cord-352796-6einbent 95 30 which which WDT cord-352796-6einbent 95 31 may may MD cord-352796-6einbent 95 32 account account VB cord-352796-6einbent 95 33 for for IN cord-352796-6einbent 95 34 the the DT cord-352796-6einbent 95 35 relatively relatively RB cord-352796-6einbent 95 36 low low JJ cord-352796-6einbent 95 37 incidence incidence NN cord-352796-6einbent 95 38 of of IN cord-352796-6einbent 95 39 keratitis keratitis NN cord-352796-6einbent 95 40 / / SYM cord-352796-6einbent 95 41 conjunctivitis conjunctivitis NN cord-352796-6einbent 95 42 reported report VBD cord-352796-6einbent 95 43 to to IN cord-352796-6einbent 95 44 date date NN cord-352796-6einbent 95 45 ( ( -LRB- cord-352796-6einbent 95 46 7 7 CD cord-352796-6einbent 95 47 , , , cord-352796-6einbent 95 48 486 486 CD cord-352796-6einbent 95 49 ) ) -RRB- cord-352796-6einbent 95 50 . . . cord-352796-6einbent 96 1 The the DT cord-352796-6einbent 96 2 tear tear JJ cord-352796-6einbent 96 3 film film NN cord-352796-6einbent 96 4 lipid lipid NN cord-352796-6einbent 96 5 layer layer NN cord-352796-6einbent 96 6 plays play VBZ cord-352796-6einbent 96 7 an an DT cord-352796-6einbent 96 8 important important JJ cord-352796-6einbent 96 9 role role NN cord-352796-6einbent 96 10 in in IN cord-352796-6einbent 96 11 retarding retard VBG cord-352796-6einbent 96 12 tear tear JJ cord-352796-6einbent 96 13 film film NN cord-352796-6einbent 96 14 evaporation evaporation NN cord-352796-6einbent 96 15 and and CC cord-352796-6einbent 96 16 tear tear NN cord-352796-6einbent 96 17 spillage spillage NN cord-352796-6einbent 96 18 ( ( -LRB- cord-352796-6einbent 96 19 49 49 CD cord-352796-6einbent 96 20 ) ) -RRB- cord-352796-6einbent 96 21 . . . cord-352796-6einbent 97 1 However however RB cord-352796-6einbent 97 2 , , , cord-352796-6einbent 97 3 this this DT cord-352796-6einbent 97 4 lipophilicity lipophilicity NN cord-352796-6einbent 97 5 and and CC cord-352796-6einbent 97 6 that that DT cord-352796-6einbent 97 7 of of IN cord-352796-6einbent 97 8 the the DT cord-352796-6einbent 97 9 periocular periocular NN cord-352796-6einbent 97 10 skin skin NN cord-352796-6einbent 97 11 ( ( -LRB- cord-352796-6einbent 97 12 50 50 CD cord-352796-6einbent 97 13 ) ) -RRB- cord-352796-6einbent 97 14 ( ( -LRB- cord-352796-6einbent 97 15 57 57 CD cord-352796-6einbent 97 16 ) ) -RRB- cord-352796-6einbent 97 17 ( ( -LRB- cord-352796-6einbent 97 18 58 58 CD cord-352796-6einbent 97 19 ) ) -RRB- cord-352796-6einbent 97 20 ( ( -LRB- cord-352796-6einbent 97 21 59 59 CD cord-352796-6einbent 97 22 ) ) -RRB- cord-352796-6einbent 97 23 . . . cord-352796-6einbent 98 1 While while IN cord-352796-6einbent 98 2 it -PRON- PRP cord-352796-6einbent 98 3 was be VBD cord-352796-6einbent 98 4 found find VBN cord-352796-6einbent 98 5 that that IN cord-352796-6einbent 98 6 no no DT cord-352796-6einbent 98 7 viral viral JJ cord-352796-6einbent 98 8 RNA RNA NNP cord-352796-6einbent 98 9 was be VBD cord-352796-6einbent 98 10 detected detect VBN cord-352796-6einbent 98 11 in in IN cord-352796-6einbent 98 12 the the DT cord-352796-6einbent 98 13 tear tear JJ cord-352796-6einbent 98 14 fluid fluid NN cord-352796-6einbent 98 15 and and CC cord-352796-6einbent 98 16 conjunctival conjunctival JJ cord-352796-6einbent 98 17 secretions secretion NNS cord-352796-6einbent 98 18 of of IN cord-352796-6einbent 98 19 infected infected JJ cord-352796-6einbent 98 20 patients patient NNS cord-352796-6einbent 98 21 without without IN cord-352796-6einbent 98 22 conjunctivitis conjunctivitis NN cord-352796-6einbent 98 23 in in IN cord-352796-6einbent 98 24 one one CD cord-352796-6einbent 98 25 study study NN cord-352796-6einbent 98 26 , , , cord-352796-6einbent 98 27 it -PRON- PRP cord-352796-6einbent 98 28 was be VBD cord-352796-6einbent 98 29 felt feel VBN cord-352796-6einbent 98 30 that that IN cord-352796-6einbent 98 31 this this DT cord-352796-6einbent 98 32 did do VBD cord-352796-6einbent 98 33 not not RB cord-352796-6einbent 98 34 eliminate eliminate VB cord-352796-6einbent 98 35 the the DT cord-352796-6einbent 98 36 risk risk NN cord-352796-6einbent 98 37 of of IN cord-352796-6einbent 98 38 transmission transmission NN cord-352796-6einbent 98 39 via via IN cord-352796-6einbent 98 40 this this DT cord-352796-6einbent 98 41 pathway pathway NN cord-352796-6einbent 98 42 ( ( -LRB- cord-352796-6einbent 98 43 57 57 CD cord-352796-6einbent 98 44 ) ) -RRB- cord-352796-6einbent 98 45 . . . cord-352796-6einbent 99 1 The the DT cord-352796-6einbent 99 2 finding finding NN cord-352796-6einbent 99 3 that that IN cord-352796-6einbent 99 4 human human JJ cord-352796-6einbent 99 5 conjunctival conjunctival NN cord-352796-6einbent 99 6 explant explant NN cord-352796-6einbent 99 7 cultures culture NNS cord-352796-6einbent 99 8 were be VBD cord-352796-6einbent 99 9 more more RBR cord-352796-6einbent 99 10 extensively extensively RB cord-352796-6einbent 99 11 infected infect VBN cord-352796-6einbent 99 12 by by IN cord-352796-6einbent 99 13 SARS SARS NNP cord-352796-6einbent 99 14 - - HYPH cord-352796-6einbent 99 15 CoV-2 CoV-2 NNP cord-352796-6einbent 99 16 than than IN cord-352796-6einbent 99 17 by by IN cord-352796-6einbent 99 18 SARS SARS NNP cord-352796-6einbent 99 19 - - HYPH cord-352796-6einbent 99 20 CoV CoV NNP cord-352796-6einbent 99 21 is be VBZ cord-352796-6einbent 99 22 also also RB cord-352796-6einbent 99 23 significant significant JJ cord-352796-6einbent 99 24 ( ( -LRB- cord-352796-6einbent 99 25 46 46 CD cord-352796-6einbent 99 26 ) ) -RRB- cord-352796-6einbent 99 27 . . . cord-352796-6einbent 100 1 Taken take VBN cord-352796-6einbent 100 2 together together RB cord-352796-6einbent 100 3 , , , cord-352796-6einbent 100 4 these these DT cord-352796-6einbent 100 5 findings finding NNS cord-352796-6einbent 100 6 are be VBP cord-352796-6einbent 100 7 also also RB cord-352796-6einbent 100 8 consistent consistent JJ cord-352796-6einbent 100 9 with with IN cord-352796-6einbent 100 10 the the DT cord-352796-6einbent 100 11 concept concept NN cord-352796-6einbent 100 12 that that IN cord-352796-6einbent 100 13 the the DT cord-352796-6einbent 100 14 tear tear JJ cord-352796-6einbent 100 15 film film NN cord-352796-6einbent 100 16 may may MD cord-352796-6einbent 100 17 protect protect VB cord-352796-6einbent 100 18 the the DT cord-352796-6einbent 100 19 ocular ocular JJ cord-352796-6einbent 100 20 surface surface NN cord-352796-6einbent 100 21 from from IN cord-352796-6einbent 100 22 epithelial epithelial JJ cord-352796-6einbent 100 23 infection infection NN cord-352796-6einbent 100 24 and and CC cord-352796-6einbent 100 25 convey convey VB cord-352796-6einbent 100 26 virus virus NN cord-352796-6einbent 100 27 downstream downstream RB cord-352796-6einbent 100 28 . . . cord-352796-6einbent 101 1 The the DT cord-352796-6einbent 101 2 nasolacrimal nasolacrimal NN cord-352796-6einbent 101 3 system system NN cord-352796-6einbent 101 4 , , , cord-352796-6einbent 101 5 via via IN cord-352796-6einbent 101 6 the the DT cord-352796-6einbent 101 7 nasopharynx nasopharynx NN cord-352796-6einbent 101 8 ( ( -LRB- cord-352796-6einbent 101 9 considered consider VBN cord-352796-6einbent 101 10 crucial crucial JJ cord-352796-6einbent 101 11 for for IN cord-352796-6einbent 101 12 viral viral JJ cord-352796-6einbent 101 13 replication replication NN cord-352796-6einbent 101 14 ( ( -LRB- cord-352796-6einbent 101 15 46 46 CD cord-352796-6einbent 101 16 ) ) -RRB- cord-352796-6einbent 101 17 ) ) -RRB- cord-352796-6einbent 101 18 thus thus RB cord-352796-6einbent 101 19 provides provide VBZ cord-352796-6einbent 101 20 a a DT cord-352796-6einbent 101 21 bridge bridge NN cord-352796-6einbent 101 22 between between IN cord-352796-6einbent 101 23 ocular ocular JJ cord-352796-6einbent 101 24 and and CC cord-352796-6einbent 101 25 respiratory respiratory JJ cord-352796-6einbent 101 26 tissues tissue NNS cord-352796-6einbent 101 27 , , , cord-352796-6einbent 101 28 serving serve VBG cord-352796-6einbent 101 29 as as IN cord-352796-6einbent 101 30 a a DT cord-352796-6einbent 101 31 conduit conduit NN cord-352796-6einbent 101 32 for for IN cord-352796-6einbent 101 33 viruscontaining viruscontaine VBG cord-352796-6einbent 101 34 fluid fluid JJ cord-352796-6einbent 101 35 exchange exchange NN cord-352796-6einbent 101 36 between between IN cord-352796-6einbent 101 37 these these DT cord-352796-6einbent 101 38 sites site NNS cord-352796-6einbent 101 39 ( ( -LRB- cord-352796-6einbent 101 40 60 60 CD cord-352796-6einbent 101 41 ) ) -RRB- cord-352796-6einbent 101 42 . . . cord-352796-6einbent 102 1 Furthermore furthermore RB cord-352796-6einbent 102 2 , , , cord-352796-6einbent 102 3 beyond beyond IN cord-352796-6einbent 102 4 the the DT cord-352796-6einbent 102 5 anatomical anatomical JJ cord-352796-6einbent 102 6 linkage linkage NN cord-352796-6einbent 102 7 , , , cord-352796-6einbent 102 8 it -PRON- PRP cord-352796-6einbent 102 9 was be VBD cord-352796-6einbent 102 10 recognized recognize VBN cord-352796-6einbent 102 11 that that IN cord-352796-6einbent 102 12 the the DT cord-352796-6einbent 102 13 structure structure NN cord-352796-6einbent 102 14 and and CC cord-352796-6einbent 102 15 distribution distribution NN cord-352796-6einbent 102 16 of of IN cord-352796-6einbent 102 17 cellular cellular JJ cord-352796-6einbent 102 18 receptors receptor NNS cord-352796-6einbent 102 19 in in IN cord-352796-6einbent 102 20 these these DT cord-352796-6einbent 102 21 systems system NNS cord-352796-6einbent 102 22 is be VBZ cord-352796-6einbent 102 23 likely likely RB cord-352796-6einbent 102 24 contributing contribute VBG cord-352796-6einbent 102 25 to to IN cord-352796-6einbent 102 26 the the DT cord-352796-6einbent 102 27 tissue tissue NN cord-352796-6einbent 102 28 tropism tropism NN cord-352796-6einbent 102 29 of of IN cord-352796-6einbent 102 30 respiratory respiratory JJ cord-352796-6einbent 102 31 viruses virus NNS cord-352796-6einbent 102 32 ( ( -LRB- cord-352796-6einbent 102 33 60 60 CD cord-352796-6einbent 102 34 ) ) -RRB- cord-352796-6einbent 102 35 . . . cord-352796-6einbent 103 1 Furthermore furthermore RB cord-352796-6einbent 103 2 , , , cord-352796-6einbent 103 3 there there EX cord-352796-6einbent 103 4 is be VBZ cord-352796-6einbent 103 5 respiratory respiratory JJ cord-352796-6einbent 103 6 - - HYPH cord-352796-6einbent 103 7 ocular ocular JJ cord-352796-6einbent 103 8 mucosal mucosal JJ cord-352796-6einbent 103 9 immune immune JJ cord-352796-6einbent 103 10 interdependence interdependence NN cord-352796-6einbent 103 11 with with IN cord-352796-6einbent 103 12 linkage linkage NN cord-352796-6einbent 103 13 via via IN cord-352796-6einbent 103 14 the the DT cord-352796-6einbent 103 15 nasolacrimal nasolacrimal JJ cord-352796-6einbent 103 16 lymphoid lymphoid JJ cord-352796-6einbent 103 17 tissue tissue NN cord-352796-6einbent 103 18 ( ( -LRB- cord-352796-6einbent 103 19 6 6 CD cord-352796-6einbent 103 20 , , , cord-352796-6einbent 103 21 61 61 CD cord-352796-6einbent 103 22 ) ) -RRB- cord-352796-6einbent 103 23 . . . cord-352796-6einbent 104 1 Despite despite IN cord-352796-6einbent 104 2 early early JJ cord-352796-6einbent 104 3 suggestions suggestion NNS cord-352796-6einbent 104 4 of of IN cord-352796-6einbent 104 5 ocular ocular JJ cord-352796-6einbent 104 6 involvement involvement NN cord-352796-6einbent 104 7 ( ( -LRB- cord-352796-6einbent 104 8 62 62 CD cord-352796-6einbent 104 9 ) ) -RRB- cord-352796-6einbent 104 10 in in IN cord-352796-6einbent 104 11 this this DT cord-352796-6einbent 104 12 process process NN cord-352796-6einbent 104 13 , , , cord-352796-6einbent 104 14 it -PRON- PRP cord-352796-6einbent 104 15 appears appear VBZ cord-352796-6einbent 104 16 that that IN cord-352796-6einbent 104 17 this this DT cord-352796-6einbent 104 18 was be VBD cord-352796-6einbent 104 19 not not RB cord-352796-6einbent 104 20 taken take VBN cord-352796-6einbent 104 21 into into IN cord-352796-6einbent 104 22 consideration consideration NN cord-352796-6einbent 104 23 in in IN cord-352796-6einbent 104 24 framing frame VBG cord-352796-6einbent 104 25 early early JJ cord-352796-6einbent 104 26 guidelines guideline NNS cord-352796-6einbent 104 27 for for IN cord-352796-6einbent 104 28 protection protection NN cord-352796-6einbent 104 29 against against IN cord-352796-6einbent 104 30 infection infection NN cord-352796-6einbent 104 31 . . . cord-352796-6einbent 105 1 More more RBR cord-352796-6einbent 105 2 recently recently RB cord-352796-6einbent 105 3 , , , cord-352796-6einbent 105 4 American American NNP cord-352796-6einbent 105 5 Academy Academy NNP cord-352796-6einbent 105 6 of of IN cord-352796-6einbent 105 7 Ophthalmology Ophthalmology NNP cord-352796-6einbent 105 8 recommendations recommendation NNS cord-352796-6einbent 105 9 include include VBP cord-352796-6einbent 105 10 protection protection NN cord-352796-6einbent 105 11 for for IN cord-352796-6einbent 105 12 the the DT cord-352796-6einbent 105 13 mouth mouth NN cord-352796-6einbent 105 14 , , , cord-352796-6einbent 105 15 nose nose NN cord-352796-6einbent 105 16 and and CC cord-352796-6einbent 105 17 eyes eye NNS cord-352796-6einbent 105 18 when when WRB cord-352796-6einbent 105 19 caring care VBG cord-352796-6einbent 105 20 for for IN cord-352796-6einbent 105 21 patients patient NNS cord-352796-6einbent 105 22 potentially potentially RB cord-352796-6einbent 105 23 infected infect VBN cord-352796-6einbent 105 24 with with IN cord-352796-6einbent 105 25 this this DT cord-352796-6einbent 105 26 virus virus NN cord-352796-6einbent 105 27 ( ( -LRB- cord-352796-6einbent 105 28 63 63 CD cord-352796-6einbent 105 29 ) ) -RRB- cord-352796-6einbent 105 30 . . . cord-352796-6einbent 106 1 Thus thus RB cord-352796-6einbent 106 2 , , , cord-352796-6einbent 106 3 the the DT cord-352796-6einbent 106 4 pathophysiology pathophysiology NN cord-352796-6einbent 106 5 of of IN cord-352796-6einbent 106 6 ocular ocular JJ cord-352796-6einbent 106 7 surface surface NN cord-352796-6einbent 106 8 - - HYPH cord-352796-6einbent 106 9 SARS SARS NNP cord-352796-6einbent 106 10 - - HYPH cord-352796-6einbent 106 11 CoV-2 CoV-2 NNP cord-352796-6einbent 106 12 interactions interaction NNS cord-352796-6einbent 106 13 requires require VBZ cord-352796-6einbent 106 14 reevaluation reevaluation NN cord-352796-6einbent 106 15 , , , cord-352796-6einbent 106 16 not not RB cord-352796-6einbent 106 17 only only RB cord-352796-6einbent 106 18 to to TO cord-352796-6einbent 106 19 determine determine VB cord-352796-6einbent 106 20 the the DT cord-352796-6einbent 106 21 dynamics dynamic NNS cord-352796-6einbent 106 22 of of IN cord-352796-6einbent 106 23 ocular ocular JJ cord-352796-6einbent 106 24 surface surface NN cord-352796-6einbent 106 25 viral viral JJ cord-352796-6einbent 106 26 exposure exposure NN cord-352796-6einbent 106 27 and and CC cord-352796-6einbent 106 28 binding binding NN cord-352796-6einbent 106 29 but but CC cord-352796-6einbent 106 30 also also RB cord-352796-6einbent 106 31 transmission transmission NN cord-352796-6einbent 106 32 via via IN cord-352796-6einbent 106 33 the the DT cord-352796-6einbent 106 34 lacrimal lacrimal JJ cord-352796-6einbent 106 35 drainage drainage NN cord-352796-6einbent 106 36 system system NN cord-352796-6einbent 106 37 . . . cord-352796-6einbent 107 1 Less less RBR cord-352796-6einbent 107 2 pathogenic pathogenic JJ cord-352796-6einbent 107 3 coronaviruses coronaviruse NNS cord-352796-6einbent 107 4 as as RB cord-352796-6einbent 107 5 well well RB cord-352796-6einbent 107 6 as as IN cord-352796-6einbent 107 7 other other JJ cord-352796-6einbent 107 8 respiratory respiratory JJ cord-352796-6einbent 107 9 viruses virus NNS cord-352796-6einbent 107 10 could could MD cord-352796-6einbent 107 11 be be VB cord-352796-6einbent 107 12 used use VBN cord-352796-6einbent 107 13 in in IN cord-352796-6einbent 107 14 animal animal NN cord-352796-6einbent 107 15 models model NNS cord-352796-6einbent 107 16 to to TO cord-352796-6einbent 107 17 better better RB cord-352796-6einbent 107 18 elucidate elucidate VB cord-352796-6einbent 107 19 this this DT cord-352796-6einbent 107 20 relatively relatively RB cord-352796-6einbent 107 21 unexplored unexplored JJ cord-352796-6einbent 107 22 pathway pathway NN cord-352796-6einbent 107 23 . . . cord-352796-6einbent 108 1 Thus thus RB cord-352796-6einbent 108 2 , , , cord-352796-6einbent 108 3 the the DT cord-352796-6einbent 108 4 ocular ocular JJ cord-352796-6einbent 108 5 surface surface NN cord-352796-6einbent 108 6 , , , cord-352796-6einbent 108 7 representing represent VBG cord-352796-6einbent 108 8 a a DT cord-352796-6einbent 108 9 large large JJ cord-352796-6einbent 108 10 surface surface NN cord-352796-6einbent 108 11 area area NN cord-352796-6einbent 108 12 , , , cord-352796-6einbent 108 13 exposed expose VBN cord-352796-6einbent 108 14 to to IN cord-352796-6einbent 108 15 and and CC cord-352796-6einbent 108 16 likely likely RB cord-352796-6einbent 108 17 receptive receptive JJ cord-352796-6einbent 108 18 to to IN cord-352796-6einbent 108 19 coronavirus coronavirus NN cord-352796-6einbent 108 20 , , , cord-352796-6einbent 108 21 bearing bear VBG cord-352796-6einbent 108 22 the the DT cord-352796-6einbent 108 23 appropriate appropriate JJ cord-352796-6einbent 108 24 SARS SARS NNP cord-352796-6einbent 108 25 - - HYPH cord-352796-6einbent 108 26 CoV-2 CoV-2 NNP cord-352796-6einbent 108 27 entry entry NN cord-352796-6einbent 108 28 factors factor NNS cord-352796-6einbent 108 29 , , , cord-352796-6einbent 108 30 may may MD cord-352796-6einbent 108 31 be be VB cord-352796-6einbent 108 32 an an DT cord-352796-6einbent 108 33 ideal ideal JJ cord-352796-6einbent 108 34 point point NN cord-352796-6einbent 108 35 of of IN cord-352796-6einbent 108 36 intervention intervention NN cord-352796-6einbent 108 37 . . . cord-352796-6einbent 109 1 Efforts effort NNS cord-352796-6einbent 109 2 in in IN cord-352796-6einbent 109 3 directly directly RB cord-352796-6einbent 109 4 targeting target VBG cord-352796-6einbent 109 5 the the DT cord-352796-6einbent 109 6 ACE2 ACE2 NNP cord-352796-6einbent 109 7 receptor receptor NN cord-352796-6einbent 109 8 in in IN cord-352796-6einbent 109 9 this this DT cord-352796-6einbent 109 10 way way NN cord-352796-6einbent 109 11 are be VBP cord-352796-6einbent 109 12 limited limit VBN cord-352796-6einbent 109 13 ( ( -LRB- cord-352796-6einbent 109 14 64 64 CD cord-352796-6einbent 109 15 ) ) -RRB- cord-352796-6einbent 109 16 . . . cord-352796-6einbent 110 1 Potentially potentially RB cord-352796-6einbent 110 2 , , , cord-352796-6einbent 110 3 blocking block VBG cord-352796-6einbent 110 4 the the DT cord-352796-6einbent 110 5 ACE2 ACE2 NNP cord-352796-6einbent 110 6 receptor receptor NN cord-352796-6einbent 110 7 would would MD cord-352796-6einbent 110 8 deprive deprive VB cord-352796-6einbent 110 9 coronaviruses coronaviruse NNS cord-352796-6einbent 110 10 from from IN cord-352796-6einbent 110 11 their -PRON- PRP$ cord-352796-6einbent 110 12 main main JJ cord-352796-6einbent 110 13 point point NN cord-352796-6einbent 110 14 of of IN cord-352796-6einbent 110 15 tissue tissue NN cord-352796-6einbent 110 16 binding binding NN cord-352796-6einbent 110 17 . . . cord-352796-6einbent 111 1 P4 p4 NN cord-352796-6einbent 111 2 and and CC cord-352796-6einbent 111 3 P5 p5 NN cord-352796-6einbent 111 4 peptides peptide NNS cord-352796-6einbent 111 5 and and CC cord-352796-6einbent 111 6 NAAE NAAE NNP cord-352796-6einbent 112 1 , , , cord-352796-6einbent 112 2 a a DT cord-352796-6einbent 112 3 small small JJ cord-352796-6einbent 112 4 molecule molecule NN cord-352796-6einbent 112 5 targeting target VBG cord-352796-6einbent 112 6 ACE2 ACE2 NNP cord-352796-6einbent 112 7 have have VBP cord-352796-6einbent 112 8 been be VBN cord-352796-6einbent 112 9 developed develop VBN cord-352796-6einbent 112 10 but but CC cord-352796-6einbent 112 11 there there EX cord-352796-6einbent 112 12 have have VBP cord-352796-6einbent 112 13 been be VBN cord-352796-6einbent 112 14 concerns concern NNS cord-352796-6einbent 112 15 about about IN cord-352796-6einbent 112 16 a a DT cord-352796-6einbent 112 17 narrow narrow JJ cord-352796-6einbent 112 18 spectrum spectrum NN cord-352796-6einbent 112 19 of of IN cord-352796-6einbent 112 20 activity activity NN cord-352796-6einbent 112 21 and and CC cord-352796-6einbent 112 22 effects effect NNS cord-352796-6einbent 112 23 on on IN cord-352796-6einbent 112 24 blood blood NN cord-352796-6einbent 112 25 pressure pressure NN cord-352796-6einbent 112 26 regulation regulation NN cord-352796-6einbent 112 27 ( ( -LRB- cord-352796-6einbent 112 28 65 65 CD cord-352796-6einbent 112 29 ) ) -RRB- cord-352796-6einbent 112 30 . . . cord-352796-6einbent 113 1 This this DT cord-352796-6einbent 113 2 strategy strategy NN cord-352796-6einbent 113 3 has have VBZ cord-352796-6einbent 113 4 previously previously RB cord-352796-6einbent 113 5 been be VBN cord-352796-6einbent 113 6 employed employ VBN cord-352796-6einbent 113 7 , , , cord-352796-6einbent 113 8 using use VBG cord-352796-6einbent 113 9 antibodies antibody NNS cord-352796-6einbent 113 10 ( ( -LRB- cord-352796-6einbent 113 11 66 66 CD cord-352796-6einbent 113 12 ) ) -RRB- cord-352796-6einbent 113 13 -anti -anti NNS cord-352796-6einbent 113 14 - - : cord-352796-6einbent 113 15 ACE2 ACE2 NNP cord-352796-6einbent 113 16 but but CC cord-352796-6einbent 113 17 not not RB cord-352796-6einbent 113 18 anti anti JJ cord-352796-6einbent 113 19 - - JJ cord-352796-6einbent 113 20 ACE1 ace1 JJ cord-352796-6einbent 113 21 antibody antibody NN cord-352796-6einbent 113 22 blocked block VBD cord-352796-6einbent 113 23 viral viral JJ cord-352796-6einbent 113 24 replication replication NN cord-352796-6einbent 113 25 in in IN cord-352796-6einbent 113 26 a a DT cord-352796-6einbent 113 27 model model NN cord-352796-6einbent 113 28 system system NN cord-352796-6einbent 113 29 . . . cord-352796-6einbent 114 1 Blocking block VBG cord-352796-6einbent 114 2 of of IN cord-352796-6einbent 114 3 TMPRSS2 TMPRSS2 NNP cord-352796-6einbent 114 4 protease protease NN cord-352796-6einbent 114 5 and and CC cord-352796-6einbent 114 6 cathepsin cathepsin NN cord-352796-6einbent 114 7 B B NNP cord-352796-6einbent 114 8 / / SYM cord-352796-6einbent 114 9 L l NN cord-352796-6einbent 114 10 activity activity NN cord-352796-6einbent 114 11 could could MD cord-352796-6einbent 114 12 also also RB cord-352796-6einbent 114 13 be be VB cord-352796-6einbent 114 14 considered consider VBN cord-352796-6einbent 114 15 , , , cord-352796-6einbent 114 16 however however RB cord-352796-6einbent 114 17 it -PRON- PRP cord-352796-6einbent 114 18 appears appear VBZ cord-352796-6einbent 114 19 that that IN cord-352796-6einbent 114 20 ACE2 ACE2 NNP cord-352796-6einbent 114 21 , , , cord-352796-6einbent 114 22 rather rather RB cord-352796-6einbent 114 23 than than IN cord-352796-6einbent 114 24 protease protease NN cord-352796-6einbent 114 25 activity activity NN cord-352796-6einbent 114 26 , , , cord-352796-6einbent 114 27 may may MD cord-352796-6einbent 114 28 be be VB cord-352796-6einbent 114 29 the the DT cord-352796-6einbent 114 30 viral viral JJ cord-352796-6einbent 114 31 entry entry NN cord-352796-6einbent 114 32 rate rate NN cord-352796-6einbent 114 33 limiting limit VBG cord-352796-6einbent 114 34 factor factor NN cord-352796-6einbent 114 35 ( ( -LRB- cord-352796-6einbent 114 36 45 45 CD cord-352796-6einbent 114 37 ) ) -RRB- cord-352796-6einbent 114 38 . . . cord-352796-6einbent 115 1 A a DT cord-352796-6einbent 115 2 search search NN cord-352796-6einbent 115 3 of of IN cord-352796-6einbent 115 4 FDA FDA NNP cord-352796-6einbent 115 5 - - HYPH cord-352796-6einbent 115 6 approved approve VBN cord-352796-6einbent 115 7 drug drug NN cord-352796-6einbent 115 8 libraries library NNS cord-352796-6einbent 115 9 identified identify VBD cord-352796-6einbent 115 10 a a DT cord-352796-6einbent 115 11 number number NN cord-352796-6einbent 115 12 of of IN cord-352796-6einbent 115 13 drugs drug NNS cord-352796-6einbent 115 14 including include VBG cord-352796-6einbent 115 15 chloroquine chloroquine NN cord-352796-6einbent 115 16 as as IN cord-352796-6einbent 115 17 potentially potentially RB cord-352796-6einbent 115 18 having have VBG cord-352796-6einbent 115 19 anti anti JJ cord-352796-6einbent 115 20 - - JJ cord-352796-6einbent 115 21 coronavirus coronavirus JJ cord-352796-6einbent 115 22 actions action NNS cord-352796-6einbent 115 23 ( ( -LRB- cord-352796-6einbent 115 24 71 71 CD cord-352796-6einbent 115 25 ) ) -RRB- cord-352796-6einbent 115 26 and and CC cord-352796-6einbent 115 27 therefore therefore RB cord-352796-6einbent 115 28 potentially potentially RB cord-352796-6einbent 115 29 able able JJ cord-352796-6einbent 115 30 to to TO cord-352796-6einbent 115 31 be be VB cord-352796-6einbent 115 32 repurposed repurpose VBN cord-352796-6einbent 115 33 . . . cord-352796-6einbent 116 1 Table table NN cord-352796-6einbent 116 2 2 2 CD cord-352796-6einbent 116 3 summarises summarise VBZ cord-352796-6einbent 116 4 the the DT cord-352796-6einbent 116 5 drugs drug NNS cord-352796-6einbent 116 6 that that WDT cord-352796-6einbent 116 7 have have VBP cord-352796-6einbent 116 8 been be VBN cord-352796-6einbent 116 9 identified identify VBN cord-352796-6einbent 116 10 as as IN cord-352796-6einbent 116 11 potential potential JJ cord-352796-6einbent 116 12 treatments treatment NNS cord-352796-6einbent 116 13 for for IN cord-352796-6einbent 116 14 coronavirus coronavirus NN cord-352796-6einbent 116 15 infection infection NN cord-352796-6einbent 116 16 , , , cord-352796-6einbent 116 17 their -PRON- PRP$ cord-352796-6einbent 116 18 efficacy efficacy NN cord-352796-6einbent 116 19 ( ( -LRB- cord-352796-6einbent 116 20 in in IN cord-352796-6einbent 116 21 vitro vitro FW cord-352796-6einbent 116 22 and and CC cord-352796-6einbent 116 23 in in IN cord-352796-6einbent 116 24 vivo vivo NNP cord-352796-6einbent 116 25 ) ) -RRB- cord-352796-6einbent 116 26 and and CC cord-352796-6einbent 116 27 for for IN cord-352796-6einbent 116 28 which which WDT cord-352796-6einbent 116 29 there there EX cord-352796-6einbent 116 30 is be VBZ cord-352796-6einbent 116 31 data datum NNS cord-352796-6einbent 116 32 ( ( -LRB- cord-352796-6einbent 116 33 for for IN cord-352796-6einbent 116 34 that that DT cord-352796-6einbent 116 35 agent agent NN cord-352796-6einbent 116 36 or or CC cord-352796-6einbent 116 37 a a DT cord-352796-6einbent 116 38 related related JJ cord-352796-6einbent 116 39 compound compound NN cord-352796-6einbent 116 40 ) ) -RRB- cord-352796-6einbent 116 41 for for IN cord-352796-6einbent 116 42 previous previous JJ cord-352796-6einbent 116 43 topical topical JJ cord-352796-6einbent 116 44 ocular ocular JJ cord-352796-6einbent 116 45 surface surface NN cord-352796-6einbent 116 46 usage usage NN cord-352796-6einbent 116 47 . . . cord-352796-6einbent 117 1 It -PRON- PRP cord-352796-6einbent 117 2 is be VBZ cord-352796-6einbent 117 3 apparent apparent JJ cord-352796-6einbent 117 4 that that IN cord-352796-6einbent 117 5 while while IN cord-352796-6einbent 117 6 for for IN cord-352796-6einbent 117 7 each each DT cord-352796-6einbent 117 8 of of IN cord-352796-6einbent 117 9 these these DT cord-352796-6einbent 117 10 agents agent NNS cord-352796-6einbent 117 11 , , , cord-352796-6einbent 117 12 there there EX cord-352796-6einbent 117 13 is be VBZ cord-352796-6einbent 117 14 evidence evidence NN cord-352796-6einbent 117 15 of of IN cord-352796-6einbent 117 16 in in FW cord-352796-6einbent 117 17 vitro vitro FW cord-352796-6einbent 117 18 anti anti JJ cord-352796-6einbent 117 19 - - JJ cord-352796-6einbent 117 20 coronavirus coronavirus JJ cord-352796-6einbent 117 21 activity activity NN cord-352796-6einbent 117 22 , , , cord-352796-6einbent 117 23 there there EX cord-352796-6einbent 117 24 is be VBZ cord-352796-6einbent 117 25 a a DT cord-352796-6einbent 117 26 paucity paucity NN cord-352796-6einbent 117 27 of of IN cord-352796-6einbent 117 28 in in IN cord-352796-6einbent 117 29 vivo vivo NN cord-352796-6einbent 117 30 studies study NNS cord-352796-6einbent 117 31 . . . cord-352796-6einbent 118 1 This this DT cord-352796-6einbent 118 2 has have VBZ cord-352796-6einbent 118 3 been be VBN cord-352796-6einbent 118 4 raised raise VBN cord-352796-6einbent 118 5 as as IN cord-352796-6einbent 118 6 a a DT cord-352796-6einbent 118 7 matter matter NN cord-352796-6einbent 118 8 for for IN cord-352796-6einbent 118 9 concern concern NN cord-352796-6einbent 118 10 in in IN cord-352796-6einbent 118 11 that that IN cord-352796-6einbent 118 12 there there EX cord-352796-6einbent 118 13 are be VBP cord-352796-6einbent 118 14 precedents precedent NNS cord-352796-6einbent 118 15 for for IN cord-352796-6einbent 118 16 paradoxical paradoxical JJ cord-352796-6einbent 118 17 untoward untoward JJ cord-352796-6einbent 118 18 drug drug NN cord-352796-6einbent 118 19 systemic systemic JJ cord-352796-6einbent 118 20 effects effect NNS cord-352796-6einbent 118 21 that that WDT cord-352796-6einbent 118 22 result result VBP cord-352796-6einbent 118 23 in in IN cord-352796-6einbent 118 24 increased increase VBN cord-352796-6einbent 118 25 disease disease NN cord-352796-6einbent 118 26 severity severity NN cord-352796-6einbent 118 27 when when WRB cord-352796-6einbent 118 28 in in FW cord-352796-6einbent 118 29 vitro vitro FW cord-352796-6einbent 118 30 testing testing NN cord-352796-6einbent 118 31 alone alone RB cord-352796-6einbent 118 32 might may MD cord-352796-6einbent 118 33 suggest suggest VB cord-352796-6einbent 118 34 efficacy efficacy NN cord-352796-6einbent 118 35 ( ( -LRB- cord-352796-6einbent 118 36 85 85 CD cord-352796-6einbent 118 37 ) ) -RRB- cord-352796-6einbent 118 38 . . . cord-352796-6einbent 119 1 Chloroquine Chloroquine NNP cord-352796-6einbent 119 2 has have VBZ cord-352796-6einbent 119 3 long long RB cord-352796-6einbent 119 4 been be VBN cord-352796-6einbent 119 5 used use VBN cord-352796-6einbent 119 6 in in IN cord-352796-6einbent 119 7 the the DT cord-352796-6einbent 119 8 treatment treatment NN cord-352796-6einbent 119 9 of of IN cord-352796-6einbent 119 10 malaria malaria NN cord-352796-6einbent 119 11 and and CC cord-352796-6einbent 119 12 subsequently subsequently RB cord-352796-6einbent 119 13 , , , cord-352796-6einbent 119 14 autoimmune autoimmune JJ cord-352796-6einbent 119 15 disorders disorder NNS cord-352796-6einbent 119 16 ( ( -LRB- cord-352796-6einbent 119 17 such such JJ cord-352796-6einbent 119 18 as as IN cord-352796-6einbent 119 19 rheumatoid rheumatoid JJ cord-352796-6einbent 119 20 arthritis arthritis NN cord-352796-6einbent 119 21 ) ) -RRB- cord-352796-6einbent 119 22 as as RB cord-352796-6einbent 119 23 well well RB cord-352796-6einbent 119 24 as as IN cord-352796-6einbent 119 25 in in IN cord-352796-6einbent 119 26 oncology oncology NN cord-352796-6einbent 119 27 and and CC cord-352796-6einbent 119 28 for for IN cord-352796-6einbent 119 29 pediatric pediatric JJ cord-352796-6einbent 119 30 inflammatory inflammatory JJ cord-352796-6einbent 119 31 disease disease NN cord-352796-6einbent 119 32 . . . cord-352796-6einbent 120 1 However however RB cord-352796-6einbent 120 2 , , , cord-352796-6einbent 120 3 chloroquine chloroquine NN cord-352796-6einbent 120 4 has have VBZ cord-352796-6einbent 120 5 direct direct JJ cord-352796-6einbent 120 6 antiviral antiviral JJ cord-352796-6einbent 120 7 effects effect NNS cord-352796-6einbent 120 8 , , , cord-352796-6einbent 120 9 inhibiting inhibit VBG cord-352796-6einbent 120 10 pH ph NN cord-352796-6einbent 120 11 - - HYPH cord-352796-6einbent 120 12 dependent dependent JJ cord-352796-6einbent 120 13 steps step NNS cord-352796-6einbent 120 14 of of IN cord-352796-6einbent 120 15 the the DT cord-352796-6einbent 120 16 replication replication NN cord-352796-6einbent 120 17 of of IN cord-352796-6einbent 120 18 flaviviruses flavivirus NNS cord-352796-6einbent 120 19 , , , cord-352796-6einbent 120 20 retroviruses retrovirus NNS cord-352796-6einbent 120 21 , , , cord-352796-6einbent 120 22 and and CC cord-352796-6einbent 120 23 coronaviruses coronaviruse NNS cord-352796-6einbent 120 24 ( ( -LRB- cord-352796-6einbent 120 25 86 86 CD cord-352796-6einbent 120 26 ) ) -RRB- cord-352796-6einbent 120 27 , , , cord-352796-6einbent 120 28 exhibiting exhibit VBG cord-352796-6einbent 120 29 strong strong JJ cord-352796-6einbent 120 30 antiviral antiviral JJ cord-352796-6einbent 120 31 effects effect NNS cord-352796-6einbent 120 32 on on IN cord-352796-6einbent 120 33 coronavirus coronavirus NN cord-352796-6einbent 120 34 infection infection NN cord-352796-6einbent 120 35 of of IN cord-352796-6einbent 120 36 primate primate JJ cord-352796-6einbent 120 37 cells cell NNS cord-352796-6einbent 120 38 ( ( -LRB- cord-352796-6einbent 120 39 72 72 CD cord-352796-6einbent 120 40 , , , cord-352796-6einbent 120 41 87 87 CD cord-352796-6einbent 120 42 ) ) -RRB- cord-352796-6einbent 120 43 . . . cord-352796-6einbent 121 1 The the DT cord-352796-6einbent 121 2 drug drug NN cord-352796-6einbent 121 3 can can MD cord-352796-6einbent 121 4 be be VB cord-352796-6einbent 121 5 effective effective JJ cord-352796-6einbent 121 6 either either CC cord-352796-6einbent 121 7 before before IN cord-352796-6einbent 121 8 or or CC cord-352796-6einbent 121 9 after after IN cord-352796-6einbent 121 10 exposure exposure NN cord-352796-6einbent 121 11 to to IN cord-352796-6einbent 121 12 the the DT cord-352796-6einbent 121 13 virus virus NN cord-352796-6einbent 121 14 , , , cord-352796-6einbent 121 15 so so RB cord-352796-6einbent 121 16 could could MD cord-352796-6einbent 121 17 act act VB cord-352796-6einbent 121 18 both both DT cord-352796-6einbent 121 19 therapeutically therapeutically RB cord-352796-6einbent 121 20 and and CC cord-352796-6einbent 121 21 prophylactically prophylactically RB cord-352796-6einbent 121 22 . . . cord-352796-6einbent 122 1 Several several JJ cord-352796-6einbent 122 2 mechanisms mechanism NNS cord-352796-6einbent 122 3 have have VBP cord-352796-6einbent 122 4 been be VBN cord-352796-6einbent 122 5 proposed propose VBN cord-352796-6einbent 123 1 but but CC cord-352796-6einbent 123 2 of of IN cord-352796-6einbent 123 3 particular particular JJ cord-352796-6einbent 123 4 interest interest NN cord-352796-6einbent 123 5 is be VBZ cord-352796-6einbent 123 6 that that IN cord-352796-6einbent 123 7 the the DT cord-352796-6einbent 123 8 drug drug NN cord-352796-6einbent 123 9 appears appear VBZ cord-352796-6einbent 123 10 to to TO cord-352796-6einbent 123 11 interfere interfere VB cord-352796-6einbent 123 12 with with IN cord-352796-6einbent 123 13 terminal terminal JJ cord-352796-6einbent 123 14 glycosylation glycosylation NN cord-352796-6einbent 123 15 of of IN cord-352796-6einbent 123 16 ACE2 ACE2 NNP cord-352796-6einbent 123 17 ( ( -LRB- cord-352796-6einbent 123 18 87 87 CD cord-352796-6einbent 123 19 ) ) -RRB- cord-352796-6einbent 123 20 ( ( -LRB- cord-352796-6einbent 123 21 88 88 CD cord-352796-6einbent 123 22 ) ) -RRB- cord-352796-6einbent 123 23 ( ( -LRB- cord-352796-6einbent 123 24 89 89 CD cord-352796-6einbent 123 25 ) ) -RRB- cord-352796-6einbent 123 26 . . . cord-352796-6einbent 124 1 Chloroquine Chloroquine NNP cord-352796-6einbent 124 2 also also RB cord-352796-6einbent 124 3 has have VBZ cord-352796-6einbent 124 4 immunomodulatory immunomodulatory JJ cord-352796-6einbent 124 5 effects effect NNS cord-352796-6einbent 124 6 , , , cord-352796-6einbent 124 7 ( ( -LRB- cord-352796-6einbent 124 8 86 86 CD cord-352796-6einbent 124 9 , , , cord-352796-6einbent 124 10 90 90 CD cord-352796-6einbent 124 11 ) ) -RRB- cord-352796-6einbent 124 12 suppressing suppress VBG cord-352796-6einbent 124 13 the the DT cord-352796-6einbent 124 14 production production NN cord-352796-6einbent 124 15 / / SYM cord-352796-6einbent 124 16 release release NN cord-352796-6einbent 124 17 of of IN cord-352796-6einbent 124 18 tumour tumour NN cord-352796-6einbent 124 19 necrosis necrosis NN cord-352796-6einbent 124 20 factor factor NN cord-352796-6einbent 124 21 and and CC cord-352796-6einbent 124 22 interleukin interleukin NN cord-352796-6einbent 124 23 6 6 CD cord-352796-6einbent 124 24 , , , cord-352796-6einbent 124 25 which which WDT cord-352796-6einbent 124 26 may may MD cord-352796-6einbent 124 27 mitigate mitigate VB cord-352796-6einbent 124 28 the the DT cord-352796-6einbent 124 29 severe severe JJ cord-352796-6einbent 124 30 inflammatory inflammatory JJ cord-352796-6einbent 124 31 cascade cascade NN cord-352796-6einbent 124 32 associated associate VBN cord-352796-6einbent 124 33 with with IN cord-352796-6einbent 124 34 severe severe JJ cord-352796-6einbent 124 35 COVID-19 covid-19 JJ cord-352796-6einbent 124 36 disease disease NN cord-352796-6einbent 124 37 ( ( -LRB- cord-352796-6einbent 124 38 86 86 CD cord-352796-6einbent 124 39 ) ) -RRB- cord-352796-6einbent 124 40 . . . cord-352796-6einbent 125 1 Recently recently RB cord-352796-6einbent 125 2 , , , cord-352796-6einbent 125 3 hydroxychloroquine hydroxychloroquine NNP cord-352796-6einbent 125 4 was be VBD cord-352796-6einbent 125 5 found find VBN cord-352796-6einbent 125 6 to to TO cord-352796-6einbent 125 7 be be VB cord-352796-6einbent 125 8 more more RBR cord-352796-6einbent 125 9 potent potent JJ cord-352796-6einbent 125 10 than than IN cord-352796-6einbent 125 11 chloroquine chloroquine NN cord-352796-6einbent 125 12 at at IN cord-352796-6einbent 125 13 inhibiting inhibit VBG cord-352796-6einbent 125 14 SARS SARS NNP cord-352796-6einbent 125 15 - - HYPH cord-352796-6einbent 125 16 CoV-2 CoV-2 NNP cord-352796-6einbent 125 17 in in IN cord-352796-6einbent 125 18 vitro vitro FW cord-352796-6einbent 125 19 ( ( -LRB- cord-352796-6einbent 125 20 91 91 CD cord-352796-6einbent 125 21 ) ) -RRB- cord-352796-6einbent 125 22 , , , cord-352796-6einbent 125 23 fortuitous fortuitous JJ cord-352796-6einbent 125 24 , , , cord-352796-6einbent 125 25 since since IN cord-352796-6einbent 125 26 it -PRON- PRP cord-352796-6einbent 125 27 appears appear VBZ cord-352796-6einbent 125 28 that that IN cord-352796-6einbent 125 29 lower low JJR cord-352796-6einbent 125 30 toxicity toxicity NN cord-352796-6einbent 125 31 has have VBZ cord-352796-6einbent 125 32 been be VBN cord-352796-6einbent 125 33 attributed attribute VBN cord-352796-6einbent 125 34 to to IN cord-352796-6einbent 125 35 this this DT cord-352796-6einbent 125 36 derivative derivative NN cord-352796-6einbent 125 37 ( ( -LRB- cord-352796-6einbent 125 38 92 92 CD cord-352796-6einbent 125 39 ) ) -RRB- cord-352796-6einbent 125 40 . . . cord-352796-6einbent 126 1 A a DT cord-352796-6einbent 126 2 recent recent JJ cord-352796-6einbent 126 3 systematic systematic JJ cord-352796-6einbent 126 4 review review NN cord-352796-6einbent 126 5 of of IN cord-352796-6einbent 126 6 clinical clinical JJ cord-352796-6einbent 126 7 trials trial NNS cord-352796-6einbent 126 8 utilising utilise VBG cord-352796-6einbent 126 9 chloroquine chloroquine NN cord-352796-6einbent 126 10 or or CC cord-352796-6einbent 126 11 hydroxychloroquine hydroxychloroquine NN cord-352796-6einbent 126 12 ( ( -LRB- cord-352796-6einbent 126 13 74 74 CD cord-352796-6einbent 126 14 ) ) -RRB- cord-352796-6einbent 126 15 concluded conclude VBD cord-352796-6einbent 126 16 that that IN cord-352796-6einbent 126 17 5/7 5/7 CD cord-352796-6einbent 126 18 trials trial NNS cord-352796-6einbent 126 19 had have VBD cord-352796-6einbent 126 20 shown show VBN cord-352796-6einbent 126 21 favorable favorable JJ cord-352796-6einbent 126 22 outcomes outcome NNS cord-352796-6einbent 126 23 for for IN cord-352796-6einbent 126 24 patients patient NNS cord-352796-6einbent 126 25 using use VBG cord-352796-6einbent 126 26 these these DT cord-352796-6einbent 126 27 drugs drug NNS cord-352796-6einbent 126 28 and and CC cord-352796-6einbent 126 29 2/7 2/7 CD cord-352796-6einbent 126 30 demonstrated demonstrate VBD cord-352796-6einbent 126 31 no no DT cord-352796-6einbent 126 32 significant significant JJ cord-352796-6einbent 126 33 change change NN cord-352796-6einbent 126 34 compared compare VBN cord-352796-6einbent 126 35 to to IN cord-352796-6einbent 126 36 control control NN cord-352796-6einbent 126 37 . . . cord-352796-6einbent 127 1 It -PRON- PRP cord-352796-6einbent 127 2 was be VBD cord-352796-6einbent 127 3 noted note VBN cord-352796-6einbent 127 4 that that IN cord-352796-6einbent 127 5 all all DT cord-352796-6einbent 127 6 7 7 CD cord-352796-6einbent 127 7 trials trial NNS cord-352796-6einbent 127 8 carried carry VBD cord-352796-6einbent 127 9 varying vary VBG cord-352796-6einbent 127 10 degrees degree NNS cord-352796-6einbent 127 11 of of IN cord-352796-6einbent 127 12 poor poor JJ cord-352796-6einbent 127 13 study study NN cord-352796-6einbent 127 14 design design NN cord-352796-6einbent 127 15 and and CC cord-352796-6einbent 127 16 bias bias NN cord-352796-6einbent 127 17 . . . cord-352796-6einbent 128 1 One one CD cord-352796-6einbent 128 2 such such JJ cord-352796-6einbent 128 3 study study NN cord-352796-6einbent 128 4 , , , cord-352796-6einbent 128 5 a a DT cord-352796-6einbent 128 6 pilot pilot NN cord-352796-6einbent 128 7 observational observational JJ cord-352796-6einbent 128 8 study study NN cord-352796-6einbent 128 9 ( ( -LRB- cord-352796-6einbent 128 10 93 93 CD cord-352796-6einbent 128 11 ) ) -RRB- cord-352796-6einbent 128 12 showed show VBD cord-352796-6einbent 128 13 that that IN cord-352796-6einbent 128 14 use use NN cord-352796-6einbent 128 15 of of IN cord-352796-6einbent 128 16 hydroxychloroquine hydroxychloroquine NN cord-352796-6einbent 128 17 and and CC cord-352796-6einbent 128 18 azithromycin azithromycin NNP cord-352796-6einbent 128 19 demonstrated demonstrate VBD cord-352796-6einbent 128 20 apparent apparent JJ cord-352796-6einbent 128 21 improved improved JJ cord-352796-6einbent 128 22 clinical clinical JJ cord-352796-6einbent 128 23 outcomes outcome NNS cord-352796-6einbent 128 24 in in IN cord-352796-6einbent 128 25 65/80 65/80 CD cord-352796-6einbent 128 26 patients patient NNS cord-352796-6einbent 128 27 , , , cord-352796-6einbent 128 28 expanding expand VBG cord-352796-6einbent 128 29 earlier early JJR cord-352796-6einbent 128 30 work work NN cord-352796-6einbent 128 31 suggesting suggest VBG cord-352796-6einbent 128 32 that that IN cord-352796-6einbent 128 33 combined combine VBN cord-352796-6einbent 128 34 therapy therapy NN cord-352796-6einbent 128 35 resulted result VBD cord-352796-6einbent 128 36 in in IN cord-352796-6einbent 128 37 rapid rapid JJ cord-352796-6einbent 128 38 reduction reduction NN cord-352796-6einbent 128 39 in in IN cord-352796-6einbent 128 40 viral viral JJ cord-352796-6einbent 128 41 load load NN cord-352796-6einbent 128 42 . . . cord-352796-6einbent 129 1 Clearly clearly RB cord-352796-6einbent 129 2 , , , cord-352796-6einbent 129 3 more more RBR cord-352796-6einbent 129 4 robust robust JJ cord-352796-6einbent 129 5 clinical clinical JJ cord-352796-6einbent 129 6 studies study NNS cord-352796-6einbent 129 7 are be VBP cord-352796-6einbent 129 8 needed need VBN cord-352796-6einbent 129 9 and and CC cord-352796-6einbent 129 10 have have VBP cord-352796-6einbent 129 11 been be VBN cord-352796-6einbent 129 12 called call VBN cord-352796-6einbent 129 13 for for IN cord-352796-6einbent 129 14 ( ( -LRB- cord-352796-6einbent 129 15 74 74 CD cord-352796-6einbent 129 16 ) ) -RRB- cord-352796-6einbent 129 17 . . . cord-352796-6einbent 130 1 While while IN cord-352796-6einbent 130 2 systemic systemic JJ cord-352796-6einbent 130 3 chloroquine chloroquine NN cord-352796-6einbent 130 4 and and CC cord-352796-6einbent 130 5 its -PRON- PRP$ cord-352796-6einbent 130 6 derivatives derivative NNS cord-352796-6einbent 130 7 appear appear VBP cord-352796-6einbent 130 8 to to TO cord-352796-6einbent 130 9 be be VB cord-352796-6einbent 130 10 associated associate VBN cord-352796-6einbent 130 11 with with IN cord-352796-6einbent 130 12 relatively relatively RB cord-352796-6einbent 130 13 minor minor JJ cord-352796-6einbent 130 14 side side NN cord-352796-6einbent 130 15 effects effect NNS cord-352796-6einbent 130 16 in in IN cord-352796-6einbent 130 17 the the DT cord-352796-6einbent 130 18 shorter short JJR cord-352796-6einbent 130 19 term term NN cord-352796-6einbent 130 20 , , , cord-352796-6einbent 130 21 electrocardiogram electrocardiogram VB cord-352796-6einbent 130 22 QT qt NN cord-352796-6einbent 130 23 interval interval NN cord-352796-6einbent 130 24 prolongation prolongation NN cord-352796-6einbent 130 25 has have VBZ cord-352796-6einbent 130 26 been be VBN cord-352796-6einbent 130 27 reported report VBN cord-352796-6einbent 130 28 ( ( -LRB- cord-352796-6einbent 130 29 94 94 CD cord-352796-6einbent 130 30 ) ) -RRB- cord-352796-6einbent 130 31 and and CC cord-352796-6einbent 130 32 this this DT cord-352796-6einbent 130 33 may may MD cord-352796-6einbent 130 34 be be VB cord-352796-6einbent 130 35 exacerbated exacerbate VBN cord-352796-6einbent 130 36 by by IN cord-352796-6einbent 130 37 combination combination NN cord-352796-6einbent 130 38 treatemtn treatemtn NNP cord-352796-6einbent 130 39 with with IN cord-352796-6einbent 130 40 azithromycin azithromycin NNP cord-352796-6einbent 130 41 ( ( -LRB- cord-352796-6einbent 130 42 74 74 CD cord-352796-6einbent 130 43 ) ) -RRB- cord-352796-6einbent 130 44 . . . cord-352796-6einbent 131 1 The the DT cord-352796-6einbent 131 2 well well RB cord-352796-6einbent 131 3 - - HYPH cord-352796-6einbent 131 4 known know VBN cord-352796-6einbent 131 5 association association NN cord-352796-6einbent 131 6 with with IN cord-352796-6einbent 131 7 irreversible irreversible JJ cord-352796-6einbent 131 8 visual visual JJ cord-352796-6einbent 131 9 loss loss NN cord-352796-6einbent 131 10 due due IN cord-352796-6einbent 131 11 to to IN cord-352796-6einbent 131 12 retinal retinal JJ cord-352796-6einbent 131 13 toxicity toxicity NN cord-352796-6einbent 131 14 is be VBZ cord-352796-6einbent 131 15 considered consider VBN cord-352796-6einbent 131 16 a a DT cord-352796-6einbent 131 17 late late JJ cord-352796-6einbent 131 18 manifestation manifestation NN cord-352796-6einbent 131 19 ( ( -LRB- cord-352796-6einbent 131 20 95 95 CD cord-352796-6einbent 131 21 ) ) -RRB- cord-352796-6einbent 131 22 , , . cord-352796-6einbent 132 1 however however RB cord-352796-6einbent 132 2 early early JJ cord-352796-6einbent 132 3 - - HYPH cord-352796-6einbent 132 4 onset onset NN cord-352796-6einbent 132 5 ( ( -LRB- cord-352796-6einbent 132 6 ~ ~ NFP cord-352796-6einbent 132 7 2 2 CD cord-352796-6einbent 132 8 months month NNS cord-352796-6einbent 132 9 ) ) -RRB- cord-352796-6einbent 132 10 has have VBZ cord-352796-6einbent 132 11 been be VBN cord-352796-6einbent 132 12 reported report VBN cord-352796-6einbent 132 13 in in IN cord-352796-6einbent 132 14 a a DT cord-352796-6einbent 132 15 case case NN cord-352796-6einbent 132 16 where where WRB cord-352796-6einbent 132 17 the the DT cord-352796-6einbent 132 18 ideal ideal JJ cord-352796-6einbent 132 19 dosage dosage NN cord-352796-6einbent 132 20 was be VBD cord-352796-6einbent 132 21 exceeded exceed VBN cord-352796-6einbent 132 22 for for IN cord-352796-6einbent 132 23 one one CD cord-352796-6einbent 132 24 month month NN cord-352796-6einbent 132 25 ( ( -LRB- cord-352796-6einbent 132 26 96 96 CD cord-352796-6einbent 132 27 ) ) -RRB- cord-352796-6einbent 132 28 . . . cord-352796-6einbent 133 1 A a DT cord-352796-6einbent 133 2 number number NN cord-352796-6einbent 133 3 of of IN cord-352796-6einbent 133 4 predisposing predispose VBG cord-352796-6einbent 133 5 factors factor NNS cord-352796-6einbent 133 6 to to IN cord-352796-6einbent 133 7 retinal retinal JJ cord-352796-6einbent 133 8 toxicity toxicity NN cord-352796-6einbent 133 9 include include VBP cord-352796-6einbent 133 10 genetic genetic JJ cord-352796-6einbent 133 11 ( ( -LRB- cord-352796-6einbent 133 12 97 97 CD cord-352796-6einbent 133 13 ) ) -RRB- cord-352796-6einbent 134 1 -polymorphisms -polymorphism NNS cord-352796-6einbent 134 2 in in IN cord-352796-6einbent 134 3 the the DT cord-352796-6einbent 134 4 cytochrome cytochrome NN cord-352796-6einbent 134 5 P450 p450 JJ cord-352796-6einbent 134 6 gene gene NN cord-352796-6einbent 134 7 , , , cord-352796-6einbent 134 8 drug drug NN cord-352796-6einbent 134 9 interactions interaction NNS cord-352796-6einbent 134 10 ( ( -LRB- cord-352796-6einbent 134 11 98 98 CD cord-352796-6einbent 134 12 ) ) -RRB- cord-352796-6einbent 135 1 and and CC cord-352796-6einbent 135 2 racial racial JJ cord-352796-6einbent 135 3 factors factor NNS cord-352796-6einbent 135 4 ( ( -LRB- cord-352796-6einbent 135 5 99 99 CD cord-352796-6einbent 135 6 ) ) -RRB- cord-352796-6einbent 135 7 ) ) -RRB- cord-352796-6einbent 135 8 , , , cord-352796-6einbent 135 9 may may MD cord-352796-6einbent 135 10 play play VB cord-352796-6einbent 135 11 a a DT cord-352796-6einbent 135 12 role role NN cord-352796-6einbent 135 13 . . . cord-352796-6einbent 136 1 Chloroquine Chloroquine NNP cord-352796-6einbent 136 2 's 's POS cord-352796-6einbent 136 3 anticancer anticancer JJ cord-352796-6einbent 136 4 activity activity NN cord-352796-6einbent 136 5 in in IN cord-352796-6einbent 136 6 concert concert NN cord-352796-6einbent 136 7 with with IN cord-352796-6einbent 136 8 zinc zinc NN cord-352796-6einbent 136 9 have have VBP cord-352796-6einbent 136 10 been be VBN cord-352796-6einbent 136 11 explained explain VBN cord-352796-6einbent 136 12 by by IN cord-352796-6einbent 136 13 the the DT cord-352796-6einbent 136 14 fact fact NN cord-352796-6einbent 136 15 that that IN cord-352796-6einbent 136 16 chloroquine chloroquine NN cord-352796-6einbent 136 17 acts act VBZ cord-352796-6einbent 136 18 as as IN cord-352796-6einbent 136 19 a a DT cord-352796-6einbent 136 20 zinc zinc NN cord-352796-6einbent 136 21 ionophore ionophore NN cord-352796-6einbent 136 22 ( ( -LRB- cord-352796-6einbent 136 23 100 100 CD cord-352796-6einbent 136 24 ) ) -RRB- cord-352796-6einbent 136 25 , , , cord-352796-6einbent 136 26 significantly significantly RB cord-352796-6einbent 136 27 , , , cord-352796-6einbent 136 28 inhibiting inhibit VBG cord-352796-6einbent 136 29 cellular cellular JJ cord-352796-6einbent 136 30 autophagy autophagy NN cord-352796-6einbent 136 31 and and CC cord-352796-6einbent 136 32 enhancing enhance VBG cord-352796-6einbent 136 33 apoptotic apoptotic JJ cord-352796-6einbent 136 34 cell cell NN cord-352796-6einbent 136 35 death death NN cord-352796-6einbent 136 36 via via IN cord-352796-6einbent 136 37 inhibition inhibition NN cord-352796-6einbent 136 38 of of IN cord-352796-6einbent 136 39 lysosome lysosome NN cord-352796-6einbent 136 40 function function NN cord-352796-6einbent 136 41 . . . cord-352796-6einbent 137 1 It -PRON- PRP cord-352796-6einbent 137 2 transpires transpire VBZ cord-352796-6einbent 137 3 that that IN cord-352796-6einbent 137 4 zinc zinc NN cord-352796-6einbent 137 5 inhibits inhibit VBZ cord-352796-6einbent 137 6 coronavirus coronavirus NN cord-352796-6einbent 137 7 polymerase polymerase NN cord-352796-6einbent 137 8 activity activity NN cord-352796-6einbent 137 9 ( ( -LRB- cord-352796-6einbent 137 10 101 101 CD cord-352796-6einbent 137 11 ) ) -RRB- cord-352796-6einbent 137 12 , , , cord-352796-6einbent 137 13 blocking block VBG cord-352796-6einbent 137 14 viral viral JJ cord-352796-6einbent 137 15 replication replication NN cord-352796-6einbent 137 16 . . . cord-352796-6einbent 138 1 For for IN cord-352796-6einbent 138 2 this this DT cord-352796-6einbent 138 3 reason reason NN cord-352796-6einbent 138 4 , , , cord-352796-6einbent 138 5 combination combination NN cord-352796-6einbent 138 6 treatment treatment NN cord-352796-6einbent 138 7 for for IN cord-352796-6einbent 138 8 Covid-19 Covid-19 NNP cord-352796-6einbent 138 9 with with IN cord-352796-6einbent 138 10 chloroquine chloroquine NN cord-352796-6einbent 138 11 and and CC cord-352796-6einbent 138 12 zinc zinc NN cord-352796-6einbent 138 13 has have VBZ cord-352796-6einbent 138 14 been be VBN cord-352796-6einbent 138 15 suggested suggest VBN cord-352796-6einbent 138 16 ( ( -LRB- cord-352796-6einbent 138 17 102 102 CD cord-352796-6einbent 138 18 ) ) -RRB- cord-352796-6einbent 138 19 , , , cord-352796-6einbent 138 20 although although IN cord-352796-6einbent 138 21 this this DT cord-352796-6einbent 138 22 intervention intervention NN cord-352796-6einbent 138 23 has have VBZ cord-352796-6einbent 138 24 yet yet RB cord-352796-6einbent 138 25 to to TO cord-352796-6einbent 138 26 be be VB cord-352796-6einbent 138 27 formally formally RB cord-352796-6einbent 138 28 reported report VBN cord-352796-6einbent 138 29 . . . cord-352796-6einbent 139 1 It -PRON- PRP cord-352796-6einbent 139 2 is be VBZ cord-352796-6einbent 139 3 perhaps perhaps RB cord-352796-6einbent 139 4 unsurprising unsurprising JJ cord-352796-6einbent 139 5 , , , cord-352796-6einbent 139 6 given give VBN cord-352796-6einbent 139 7 the the DT cord-352796-6einbent 139 8 passage passage NN cord-352796-6einbent 139 9 of of IN cord-352796-6einbent 139 10 time time NN cord-352796-6einbent 139 11 , , , cord-352796-6einbent 139 12 that that IN cord-352796-6einbent 139 13 an an DT cord-352796-6einbent 139 14 understanding understanding NN cord-352796-6einbent 139 15 of of IN cord-352796-6einbent 139 16 viral viral JJ cord-352796-6einbent 139 17 oculotropism oculotropism NN cord-352796-6einbent 139 18 from from IN cord-352796-6einbent 139 19 the the DT cord-352796-6einbent 139 20 1918 1918 CD cord-352796-6einbent 139 21 influenza influenza NN cord-352796-6einbent 139 22 epidemic epidemic NN cord-352796-6einbent 139 23 has have VBZ cord-352796-6einbent 139 24 faded fade VBN cord-352796-6einbent 139 25 . . . cord-352796-6einbent 140 1 Yet yet CC cord-352796-6einbent 140 2 if if IN cord-352796-6einbent 140 3 SARS SARS NNP cord-352796-6einbent 140 4 - - HYPH cord-352796-6einbent 140 5 CoV-2 CoV-2 NNP cord-352796-6einbent 140 6 oculotropism oculotropism NN cord-352796-6einbent 140 7 is be VBZ cord-352796-6einbent 140 8 confirmed confirm VBN cord-352796-6einbent 140 9 , , , cord-352796-6einbent 140 10 this this DT cord-352796-6einbent 140 11 invasion invasion NN cord-352796-6einbent 140 12 entry entry NN cord-352796-6einbent 140 13 point point NN cord-352796-6einbent 140 14 also also RB cord-352796-6einbent 140 15 represents represent VBZ cord-352796-6einbent 140 16 an an DT cord-352796-6einbent 140 17 opportunity opportunity NN cord-352796-6einbent 140 18 for for IN cord-352796-6einbent 140 19 intervention intervention NN cord-352796-6einbent 140 20 . . . cord-352796-6einbent 141 1 Given give VBN cord-352796-6einbent 141 2 the the DT cord-352796-6einbent 141 3 potential potential JJ cord-352796-6einbent 141 4 toxicity toxicity NN cord-352796-6einbent 141 5 of of IN cord-352796-6einbent 141 6 apparently apparently RB cord-352796-6einbent 141 7 efficacious efficacious JJ cord-352796-6einbent 141 8 drugs drug NNS cord-352796-6einbent 141 9 and and CC cord-352796-6einbent 141 10 issues issue NNS cord-352796-6einbent 141 11 relating relate VBG cord-352796-6einbent 141 12 to to IN cord-352796-6einbent 141 13 drug drug NN cord-352796-6einbent 141 14 bioavailability bioavailability NN cord-352796-6einbent 141 15 , , , cord-352796-6einbent 141 16 initially initially RB cord-352796-6einbent 141 17 in in IN cord-352796-6einbent 141 18 the the DT cord-352796-6einbent 141 19 upper upper JJ cord-352796-6einbent 141 20 airways airway NNS cord-352796-6einbent 141 21 and and CC cord-352796-6einbent 141 22 respiratory respiratory JJ cord-352796-6einbent 141 23 system system NN cord-352796-6einbent 141 24 , , , cord-352796-6einbent 141 25 local local JJ cord-352796-6einbent 141 26 , , , cord-352796-6einbent 141 27 topical topical JJ cord-352796-6einbent 141 28 therapy therapy NN cord-352796-6einbent 141 29 offers offer VBZ cord-352796-6einbent 141 30 potential potential JJ cord-352796-6einbent 141 31 significant significant JJ cord-352796-6einbent 141 32 advantages advantage NNS cord-352796-6einbent 141 33 . . . cord-352796-6einbent 142 1 Many many JJ cord-352796-6einbent 142 2 of of IN cord-352796-6einbent 142 3 the the DT cord-352796-6einbent 142 4 proposed propose VBN cord-352796-6einbent 142 5 systemic systemic JJ cord-352796-6einbent 142 6 therapies therapy NNS cord-352796-6einbent 142 7 such such JJ cord-352796-6einbent 142 8 as as IN cord-352796-6einbent 142 9 chloroquine chloroquine NN cord-352796-6einbent 142 10 , , , cord-352796-6einbent 142 11 zinc zinc NN cord-352796-6einbent 142 12 and and CC cord-352796-6einbent 142 13 ACE ace NN cord-352796-6einbent 142 14 inhibitors inhibitor NNS cord-352796-6einbent 142 15 have have VBP cord-352796-6einbent 142 16 all all DT cord-352796-6einbent 142 17 been be VBN cord-352796-6einbent 142 18 used use VBN cord-352796-6einbent 142 19 topically topically RB cord-352796-6einbent 142 20 in in IN cord-352796-6einbent 142 21 the the DT cord-352796-6einbent 142 22 eye eye NN cord-352796-6einbent 142 23 ( ( -LRB- cord-352796-6einbent 142 24 Table Table NNP cord-352796-6einbent 142 25 2 2 CD cord-352796-6einbent 142 26 ) ) -RRB- cord-352796-6einbent 142 27 . . . cord-352796-6einbent 143 1 Chloroquine Chloroquine NNP cord-352796-6einbent 143 2 as as IN cord-352796-6einbent 143 3 0.03 0.03 CD cord-352796-6einbent 143 4 % % NN cord-352796-6einbent 143 5 chloroquine chloroquine NN cord-352796-6einbent 143 6 phosphate phosphate NN cord-352796-6einbent 143 7 eye eye NN cord-352796-6einbent 143 8 drops drop NNS cord-352796-6einbent 143 9 have have VBP cord-352796-6einbent 143 10 apparently apparently RB cord-352796-6einbent 143 11 been be VBN cord-352796-6einbent 143 12 efficacious efficacious JJ cord-352796-6einbent 143 13 in in IN cord-352796-6einbent 143 14 the the DT cord-352796-6einbent 143 15 management management NN cord-352796-6einbent 143 16 of of IN cord-352796-6einbent 143 17 dry dry JJ cord-352796-6einbent 143 18 eye eye NN cord-352796-6einbent 143 19 syndrome syndrome NN cord-352796-6einbent 143 20 in in IN cord-352796-6einbent 143 21 humans human NNS cord-352796-6einbent 143 22 ( ( -LRB- cord-352796-6einbent 143 23 75 75 CD cord-352796-6einbent 143 24 , , , cord-352796-6einbent 143 25 76 76 CD cord-352796-6einbent 143 26 ) ) -RRB- cord-352796-6einbent 143 27 . . . cord-352796-6einbent 144 1 Significant significant JJ cord-352796-6einbent 144 2 side side NN cord-352796-6einbent 144 3 effects effect NNS cord-352796-6einbent 144 4 were be VBD cord-352796-6einbent 144 5 not not RB cord-352796-6einbent 144 6 reported report VBN cord-352796-6einbent 144 7 , , , cord-352796-6einbent 144 8 however however WRB cord-352796-6einbent 144 9 there there EX cord-352796-6einbent 144 10 is be VBZ cord-352796-6einbent 144 11 a a DT cord-352796-6einbent 144 12 report report NN cord-352796-6einbent 144 13 of of IN cord-352796-6einbent 144 14 chloroquine chloroquine NNP cord-352796-6einbent 144 15 keratopathy keratopathy NNP cord-352796-6einbent 144 16 in in IN cord-352796-6einbent 144 17 workers worker NNS cord-352796-6einbent 144 18 chronically chronically RB cord-352796-6einbent 144 19 exposed expose VBN cord-352796-6einbent 144 20 to to IN cord-352796-6einbent 144 21 chloroquine chloroquine NN cord-352796-6einbent 144 22 dust dust NN cord-352796-6einbent 144 23 ( ( -LRB- cord-352796-6einbent 144 24 103 103 CD cord-352796-6einbent 144 25 ) ) -RRB- cord-352796-6einbent 144 26 . . . cord-352796-6einbent 145 1 Chronic chronic JJ cord-352796-6einbent 145 2 usage usage NN cord-352796-6einbent 145 3 is be VBZ cord-352796-6einbent 145 4 unlikely unlikely JJ cord-352796-6einbent 145 5 in in IN cord-352796-6einbent 145 6 the the DT cord-352796-6einbent 145 7 setting setting NN cord-352796-6einbent 145 8 here here RB cord-352796-6einbent 145 9 proposed propose VBD cord-352796-6einbent 145 10 . . . cord-352796-6einbent 146 1 ACE ACE NNP cord-352796-6einbent 146 2 inhibitors inhibitor NNS cord-352796-6einbent 146 3 have have VBP cord-352796-6einbent 146 4 been be VBN cord-352796-6einbent 146 5 used use VBN cord-352796-6einbent 146 6 topically topically RB cord-352796-6einbent 146 7 in in IN cord-352796-6einbent 146 8 animal animal NN cord-352796-6einbent 146 9 models model NNS cord-352796-6einbent 146 10 of of IN cord-352796-6einbent 146 11 glaucoma glaucoma NN cord-352796-6einbent 146 12 ( ( -LRB- cord-352796-6einbent 146 13 104 104 CD cord-352796-6einbent 146 14 ) ) -RRB- cord-352796-6einbent 146 15 . . . cord-352796-6einbent 147 1 In in IN cord-352796-6einbent 147 2 this this DT cord-352796-6einbent 147 3 class class NN cord-352796-6einbent 147 4 of of IN cord-352796-6einbent 147 5 drugs drug NNS cord-352796-6einbent 147 6 , , , cord-352796-6einbent 147 7 agents agent NNS cord-352796-6einbent 147 8 such such JJ cord-352796-6einbent 147 9 as as IN cord-352796-6einbent 147 10 telmisartan telmisartan NNP cord-352796-6einbent 147 11 are be VBP cord-352796-6einbent 147 12 long long RB cord-352796-6einbent 147 13 acting act VBG cord-352796-6einbent 147 14 , , , cord-352796-6einbent 147 15 with with IN cord-352796-6einbent 147 16 a a DT cord-352796-6einbent 147 17 mean mean JJ cord-352796-6einbent 147 18 half half JJ cord-352796-6einbent 147 19 - - HYPH cord-352796-6einbent 147 20 life life NN cord-352796-6einbent 147 21 of of IN cord-352796-6einbent 147 22 24 24 CD cord-352796-6einbent 147 23 hours hour NNS cord-352796-6einbent 147 24 ( ( -LRB- cord-352796-6einbent 147 25 105 105 CD cord-352796-6einbent 147 26 ) ) -RRB- cord-352796-6einbent 147 27 . . . cord-352796-6einbent 148 1 Zinc zinc NN cord-352796-6einbent 148 2 has have VBZ cord-352796-6einbent 148 3 traditionally traditionally RB cord-352796-6einbent 148 4 been be VBN cord-352796-6einbent 148 5 used use VBN cord-352796-6einbent 148 6 in in IN cord-352796-6einbent 148 7 astringent astringent JJ cord-352796-6einbent 148 8 eye eye NN cord-352796-6einbent 148 9 drops drop NNS cord-352796-6einbent 148 10 or or CC cord-352796-6einbent 148 11 as as IN cord-352796-6einbent 148 12 an an DT cord-352796-6einbent 148 13 excipient excipient NN cord-352796-6einbent 148 14 , , , cord-352796-6einbent 148 15 zinc zinc NN cord-352796-6einbent 148 16 sulphate sulphate NN cord-352796-6einbent 148 17 ( ( -LRB- cord-352796-6einbent 148 18 0.25 0.25 CD cord-352796-6einbent 148 19 % % NN cord-352796-6einbent 148 20 ) ) -RRB- cord-352796-6einbent 148 21 ( ( -LRB- cord-352796-6einbent 148 22 83 83 CD cord-352796-6einbent 148 23 ) ) -RRB- cord-352796-6einbent 148 24 . . . cord-352796-6einbent 149 1 Since since IN cord-352796-6einbent 149 2 chloroquine chloroquine NN cord-352796-6einbent 149 3 and and CC cord-352796-6einbent 149 4 ACE2 ACE2 NNP cord-352796-6einbent 149 5 inhibitors inhibitor NNS cord-352796-6einbent 149 6 seem seem VBP cord-352796-6einbent 149 7 to to TO cord-352796-6einbent 149 8 act act VB cord-352796-6einbent 149 9 at at IN cord-352796-6einbent 149 10 different different JJ cord-352796-6einbent 149 11 parts part NNS cord-352796-6einbent 149 12 of of IN cord-352796-6einbent 149 13 the the DT cord-352796-6einbent 149 14 receptor receptor NN cord-352796-6einbent 149 15 , , , cord-352796-6einbent 149 16 in in IN cord-352796-6einbent 149 17 combination combination NN cord-352796-6einbent 149 18 , , , cord-352796-6einbent 149 19 synergy synergy NN cord-352796-6einbent 149 20 is be VBZ cord-352796-6einbent 149 21 possible possible JJ cord-352796-6einbent 149 22 or or CC cord-352796-6einbent 149 23 at at IN cord-352796-6einbent 149 24 the the DT cord-352796-6einbent 149 25 very very RB cord-352796-6einbent 149 26 least least JJS cord-352796-6einbent 149 27 an an DT cord-352796-6einbent 149 28 additive additive NN cord-352796-6einbent 149 29 effect effect NN cord-352796-6einbent 149 30 , , , cord-352796-6einbent 149 31 permitting permit VBG cord-352796-6einbent 149 32 a a DT cord-352796-6einbent 149 33 reduction reduction NN cord-352796-6einbent 149 34 in in IN cord-352796-6einbent 149 35 dosage dosage NN cord-352796-6einbent 149 36 and and CC cord-352796-6einbent 149 37 risk risk NN cord-352796-6einbent 149 38 of of IN cord-352796-6einbent 149 39 potential potential JJ cord-352796-6einbent 149 40 side side NN cord-352796-6einbent 149 41 effects effect NNS cord-352796-6einbent 149 42 . . . cord-352796-6einbent 150 1 However however RB cord-352796-6einbent 150 2 , , , cord-352796-6einbent 150 3 another another DT cord-352796-6einbent 150 4 issue issue NN cord-352796-6einbent 150 5 is be VBZ cord-352796-6einbent 150 6 that that IN cord-352796-6einbent 150 7 ACE2 ACE2 NNP cord-352796-6einbent 150 8 inhibitors inhibitor NNS cord-352796-6einbent 150 9 may may MD cord-352796-6einbent 150 10 upregulate upregulate VB cord-352796-6einbent 150 11 this this DT cord-352796-6einbent 150 12 receptor receptor NN cord-352796-6einbent 150 13 ( ( -LRB- cord-352796-6einbent 150 14 106 106 CD cord-352796-6einbent 150 15 ) ) -RRB- cord-352796-6einbent 150 16 , , , cord-352796-6einbent 150 17 perhaps perhaps RB cord-352796-6einbent 150 18 increasing increase VBG cord-352796-6einbent 150 19 the the DT cord-352796-6einbent 150 20 risk risk NN cord-352796-6einbent 150 21 of of IN cord-352796-6einbent 150 22 coronavirus coronavirus NN cord-352796-6einbent 150 23 infection infection NN cord-352796-6einbent 150 24 . . . cord-352796-6einbent 151 1 Early early JJ cord-352796-6einbent 151 2 reports report NNS cord-352796-6einbent 151 3 have have VBP cord-352796-6einbent 151 4 suggested suggest VBN cord-352796-6einbent 151 5 that that IN cord-352796-6einbent 151 6 hypertension hypertension NN cord-352796-6einbent 151 7 may may MD cord-352796-6einbent 151 8 be be VB cord-352796-6einbent 151 9 a a DT cord-352796-6einbent 151 10 risk risk NN cord-352796-6einbent 151 11 factor factor NN cord-352796-6einbent 151 12 for for IN cord-352796-6einbent 151 13 infection infection NN cord-352796-6einbent 151 14 but but CC cord-352796-6einbent 151 15 these these DT cord-352796-6einbent 151 16 are be VBP cord-352796-6einbent 151 17 unconfirmed unconfirmed JJ cord-352796-6einbent 151 18 ( ( -LRB- cord-352796-6einbent 151 19 107 107 CD cord-352796-6einbent 151 20 ) ) -RRB- cord-352796-6einbent 151 21 . . . cord-352796-6einbent 152 1 Azithromycin Azithromycin NNP cord-352796-6einbent 152 2 has have VBZ cord-352796-6einbent 152 3 also also RB cord-352796-6einbent 152 4 previously previously RB cord-352796-6einbent 152 5 been be VBN cord-352796-6einbent 152 6 safely safely RB cord-352796-6einbent 152 7 used use VBN cord-352796-6einbent 152 8 topically topically RB cord-352796-6einbent 152 9 in in IN cord-352796-6einbent 152 10 the the DT cord-352796-6einbent 152 11 human human JJ cord-352796-6einbent 152 12 eye eye NN cord-352796-6einbent 152 13 as as IN cord-352796-6einbent 152 14 a a DT cord-352796-6einbent 152 15 1 1 CD cord-352796-6einbent 152 16 - - SYM cord-352796-6einbent 152 17 1.5 1.5 CD cord-352796-6einbent 152 18 % % NN cord-352796-6einbent 152 19 solution solution NN cord-352796-6einbent 152 20 to to TO cord-352796-6einbent 152 21 treat treat VB cord-352796-6einbent 152 22 ocular ocular JJ cord-352796-6einbent 152 23 infections infection NNS cord-352796-6einbent 152 24 ( ( -LRB- cord-352796-6einbent 152 25 78 78 CD cord-352796-6einbent 152 26 , , , cord-352796-6einbent 152 27 79 79 CD cord-352796-6einbent 152 28 ) ) -RRB- cord-352796-6einbent 152 29 . . . cord-352796-6einbent 153 1 In in IN cord-352796-6einbent 153 2 the the DT cord-352796-6einbent 153 3 case case NN cord-352796-6einbent 153 4 of of IN cord-352796-6einbent 153 5 hydroxychloroquine hydroxychloroquine NNP cord-352796-6einbent 153 6 , , , cord-352796-6einbent 153 7 preliminary preliminary JJ cord-352796-6einbent 153 8 calculations calculation NNS cord-352796-6einbent 153 9 suggest suggest VBP cord-352796-6einbent 153 10 that that IN cord-352796-6einbent 153 11 with with IN cord-352796-6einbent 153 12 topical topical JJ cord-352796-6einbent 153 13 application application NN cord-352796-6einbent 153 14 , , , cord-352796-6einbent 153 15 a a DT cord-352796-6einbent 153 16 dosage dosage NN cord-352796-6einbent 153 17 one one CD cord-352796-6einbent 153 18 to to IN cord-352796-6einbent 153 19 two two CD cord-352796-6einbent 153 20 orders order NNS cord-352796-6einbent 153 21 of of IN cord-352796-6einbent 153 22 magnitude magnitude NN cord-352796-6einbent 153 23 higher high JJR cord-352796-6einbent 153 24 than than IN cord-352796-6einbent 153 25 plasma plasma NN cord-352796-6einbent 153 26 levels level NNS cord-352796-6einbent 153 27 ( ( -LRB- cord-352796-6einbent 153 28 reached reach VBN cord-352796-6einbent 153 29 with with IN cord-352796-6einbent 153 30 systemic systemic JJ cord-352796-6einbent 153 31 treatment treatment NN cord-352796-6einbent 153 32 ( ( -LRB- cord-352796-6einbent 153 33 108 108 CD cord-352796-6einbent 153 34 ) ) -RRB- cord-352796-6einbent 153 35 ) ) -RRB- cord-352796-6einbent 153 36 could could MD cord-352796-6einbent 153 37 be be VB cord-352796-6einbent 153 38 achieved achieve VBN cord-352796-6einbent 153 39 . . . cord-352796-6einbent 154 1 At at IN cord-352796-6einbent 154 2 this this DT cord-352796-6einbent 154 3 point point NN cord-352796-6einbent 154 4 , , , cord-352796-6einbent 154 5 clinical clinical JJ cord-352796-6einbent 154 6 studies study NNS cord-352796-6einbent 154 7 are be VBP cord-352796-6einbent 154 8 needed need VBN cord-352796-6einbent 154 9 expeditiously expeditiously RB cord-352796-6einbent 154 10 to to TO cord-352796-6einbent 154 11 investigate investigate VB cord-352796-6einbent 154 12 the the DT cord-352796-6einbent 154 13 safety safety NN cord-352796-6einbent 154 14 and and CC cord-352796-6einbent 154 15 efficacy efficacy NN cord-352796-6einbent 154 16 of of IN cord-352796-6einbent 154 17 local local JJ cord-352796-6einbent 154 18 prophylactic prophylactic JJ cord-352796-6einbent 154 19 regimens regimen NNS cord-352796-6einbent 154 20 following follow VBG cord-352796-6einbent 154 21 exposure exposure NN cord-352796-6einbent 154 22 to to IN cord-352796-6einbent 154 23 SARS SARS NNP cord-352796-6einbent 154 24 - - HYPH cord-352796-6einbent 154 25 CoV-2 CoV-2 NNP cord-352796-6einbent 154 26 . . . cord-352796-6einbent 155 1 For for IN cord-352796-6einbent 155 2 instance instance NN cord-352796-6einbent 155 3 , , , cord-352796-6einbent 155 4 investigations investigation NNS cord-352796-6einbent 155 5 can can MD cord-352796-6einbent 155 6 include include VB cord-352796-6einbent 155 7 initial initial JJ cord-352796-6einbent 155 8 local local JJ cord-352796-6einbent 155 9 delivery delivery NN cord-352796-6einbent 155 10 of of IN cord-352796-6einbent 155 11 a a DT cord-352796-6einbent 155 12 combination combination NN cord-352796-6einbent 155 13 of of IN cord-352796-6einbent 155 14 chloroquine chloroquine NN cord-352796-6einbent 155 15 , , , cord-352796-6einbent 155 16 zinc zinc NN cord-352796-6einbent 155 17 and and CC cord-352796-6einbent 155 18 azithromycin azithromycin NN cord-352796-6einbent 155 19 to to IN cord-352796-6einbent 155 20 the the DT cord-352796-6einbent 155 21 eyelids eyelid NNS cord-352796-6einbent 155 22 and and CC cord-352796-6einbent 155 23 ocular ocular JJ cord-352796-6einbent 155 24 surface surface NN cord-352796-6einbent 155 25 with with IN cord-352796-6einbent 155 26 eye eye NN cord-352796-6einbent 155 27 drops drop NNS cord-352796-6einbent 155 28 or or CC cord-352796-6einbent 155 29 a a DT cord-352796-6einbent 155 30 spray spray NN cord-352796-6einbent 155 31 / / SYM cord-352796-6einbent 155 32 aerosol aerosol NN cord-352796-6einbent 155 33 . . . cord-352796-6einbent 156 1 This this DT cord-352796-6einbent 156 2 would would MD cord-352796-6einbent 156 3 potentially potentially RB cord-352796-6einbent 156 4 inhibit inhibit VB cord-352796-6einbent 156 5 binding bind VBG cord-352796-6einbent 156 6 of of IN cord-352796-6einbent 156 7 SARS SARS NNP cord-352796-6einbent 156 8 - - HYPH cord-352796-6einbent 156 9 CoV-2 CoV-2 NNP cord-352796-6einbent 156 10 to to IN cord-352796-6einbent 156 11 the the DT cord-352796-6einbent 156 12 likely likely JJ cord-352796-6einbent 156 13 major major JJ cord-352796-6einbent 156 14 entry entry NN cord-352796-6einbent 156 15 point point NN cord-352796-6einbent 156 16 into into IN cord-352796-6einbent 156 17 the the DT cord-352796-6einbent 156 18 human human JJ cord-352796-6einbent 156 19 body body NN cord-352796-6einbent 156 20 , , , cord-352796-6einbent 156 21 would would MD cord-352796-6einbent 156 22 reduce reduce VB cord-352796-6einbent 156 23 the the DT cord-352796-6einbent 156 24 risk risk NN cord-352796-6einbent 156 25 of of IN cord-352796-6einbent 156 26 systemic systemic JJ cord-352796-6einbent 156 27 side side NN cord-352796-6einbent 156 28 effects effect NNS cord-352796-6einbent 156 29 and and CC cord-352796-6einbent 156 30 conserve conserve VB cord-352796-6einbent 156 31 drugs drug NNS cord-352796-6einbent 156 32 that that WDT cord-352796-6einbent 156 33 may may MD cord-352796-6einbent 156 34 become become VB cord-352796-6einbent 156 35 scarce scarce JJ cord-352796-6einbent 156 36 , , , cord-352796-6einbent 156 37 since since IN cord-352796-6einbent 156 38 the the DT cord-352796-6einbent 156 39 dosage dosage NN cord-352796-6einbent 156 40 required require VBN cord-352796-6einbent 156 41 would would MD cord-352796-6einbent 156 42 be be VB cord-352796-6einbent 156 43 much much RB cord-352796-6einbent 156 44 less less JJR cord-352796-6einbent 156 45 than than IN cord-352796-6einbent 156 46 for for IN cord-352796-6einbent 156 47 systemic systemic JJ cord-352796-6einbent 156 48 treatment treatment NN cord-352796-6einbent 156 49 . . . cord-352796-6einbent 157 1 A a DT cord-352796-6einbent 157 2 spray spray NN cord-352796-6einbent 157 3 or or CC cord-352796-6einbent 157 4 aerosol aerosol NN cord-352796-6einbent 157 5 preparation preparation NN cord-352796-6einbent 157 6 would would MD cord-352796-6einbent 157 7 also also RB cord-352796-6einbent 157 8 allow allow VB cord-352796-6einbent 157 9 treatment treatment NN cord-352796-6einbent 157 10 of of IN cord-352796-6einbent 157 11 the the DT cord-352796-6einbent 157 12 nasal nasal NN cord-352796-6einbent 157 13 passages passage NNS cord-352796-6einbent 157 14 ( ( -LRB- cord-352796-6einbent 157 15 45 45 CD cord-352796-6einbent 157 16 ) ) -RRB- cord-352796-6einbent 157 17 and and CC cord-352796-6einbent 157 18 mouth mouth NN cord-352796-6einbent 157 19 ( ( -LRB- cord-352796-6einbent 157 20 109 109 CD cord-352796-6einbent 157 21 ) ) -RRB- cord-352796-6einbent 157 22 , , , cord-352796-6einbent 157 23 given give VBN cord-352796-6einbent 157 24 high high JJ cord-352796-6einbent 157 25 ACE2 ACE2 NNP cord-352796-6einbent 157 26 receptor receptor NN cord-352796-6einbent 157 27 populations population NNS cord-352796-6einbent 157 28 in in IN cord-352796-6einbent 157 29 these these DT cord-352796-6einbent 157 30 locations location NNS cord-352796-6einbent 157 31 . . . cord-352796-6einbent 158 1 However however RB cord-352796-6einbent 158 2 , , , cord-352796-6einbent 158 3 if if IN cord-352796-6einbent 158 4 the the DT cord-352796-6einbent 158 5 virus virus NN cord-352796-6einbent 158 6 is be VBZ cord-352796-6einbent 158 7 truly truly RB cord-352796-6einbent 158 8 oculotropic oculotropic JJ cord-352796-6einbent 158 9 , , , cord-352796-6einbent 158 10 this this DT cord-352796-6einbent 158 11 may may MD cord-352796-6einbent 158 12 be be VB cord-352796-6einbent 158 13 superfluous superfluous JJ cord-352796-6einbent 158 14 . . . cord-352796-6einbent 159 1 If if IN cord-352796-6einbent 159 2 a a DT cord-352796-6einbent 159 3 patient patient NN cord-352796-6einbent 159 4 has have VBZ cord-352796-6einbent 159 5 active active JJ cord-352796-6einbent 159 6 infection infection NN cord-352796-6einbent 159 7 of of IN cord-352796-6einbent 159 8 the the DT cord-352796-6einbent 159 9 respiratory respiratory JJ cord-352796-6einbent 159 10 tree tree NN cord-352796-6einbent 159 11 , , , cord-352796-6einbent 159 12 then then RB cord-352796-6einbent 159 13 this this DT cord-352796-6einbent 159 14 combined combine VBN cord-352796-6einbent 159 15 medication medication NN cord-352796-6einbent 159 16 could could MD cord-352796-6einbent 159 17 also also RB cord-352796-6einbent 159 18 be be VB cord-352796-6einbent 159 19 given give VBN cord-352796-6einbent 159 20 in in IN cord-352796-6einbent 159 21 an an DT cord-352796-6einbent 159 22 inhaled inhale VBN cord-352796-6einbent 159 23 form form NN cord-352796-6einbent 159 24 . . . cord-352796-6einbent 160 1 The the DT cord-352796-6einbent 160 2 advantage advantage NN cord-352796-6einbent 160 3 of of IN cord-352796-6einbent 160 4 this this DT cord-352796-6einbent 160 5 ACE2 ACE2 NNP cord-352796-6einbent 160 6 targeting targeting NN cord-352796-6einbent 160 7 approach approach NN cord-352796-6einbent 160 8 is be VBZ cord-352796-6einbent 160 9 that that IN cord-352796-6einbent 160 10 ACE2 ACE2 NNP cord-352796-6einbent 160 11 receptors receptor NNS cord-352796-6einbent 160 12 from from IN cord-352796-6einbent 160 13 the the DT cord-352796-6einbent 160 14 outer outer JJ cord-352796-6einbent 160 15 cornea cornea NN cord-352796-6einbent 160 16 , , , cord-352796-6einbent 160 17 through through IN cord-352796-6einbent 160 18 the the DT cord-352796-6einbent 160 19 lacrimal lacrimal JJ cord-352796-6einbent 160 20 drainage drainage NN cord-352796-6einbent 160 21 system system NN cord-352796-6einbent 160 22 to to IN cord-352796-6einbent 160 23 the the DT cord-352796-6einbent 160 24 respiratory respiratory JJ cord-352796-6einbent 160 25 and and CC cord-352796-6einbent 160 26 gastrointestinal gastrointestinal JJ cord-352796-6einbent 160 27 systems system NNS cord-352796-6einbent 160 28 as as RB cord-352796-6einbent 160 29 well well RB cord-352796-6einbent 160 30 as as IN cord-352796-6einbent 160 31 both both DT cord-352796-6einbent 160 32 nasal nasal JJ cord-352796-6einbent 160 33 and and CC cord-352796-6einbent 160 34 oral oral JJ cord-352796-6einbent 160 35 cavities cavity NNS cord-352796-6einbent 160 36 , , , cord-352796-6einbent 160 37 are be VBP cord-352796-6einbent 160 38 directly directly RB cord-352796-6einbent 160 39 accessible accessible JJ cord-352796-6einbent 160 40 to to IN cord-352796-6einbent 160 41 a a DT cord-352796-6einbent 160 42 high high JJ cord-352796-6einbent 160 43 topical topical JJ cord-352796-6einbent 160 44 drug drug NN cord-352796-6einbent 160 45 dose dose NN cord-352796-6einbent 160 46 . . . cord-352796-6einbent 161 1 Thus thus RB cord-352796-6einbent 161 2 , , , cord-352796-6einbent 161 3 the the DT cord-352796-6einbent 161 4 portals portal NNS cord-352796-6einbent 161 5 that that WDT cord-352796-6einbent 161 6 make make VBP cord-352796-6einbent 161 7 us -PRON- PRP cord-352796-6einbent 161 8 susceptible susceptible JJ cord-352796-6einbent 161 9 to to IN cord-352796-6einbent 161 10 coronavirus coronavirus NN cord-352796-6einbent 161 11 attack attack NN cord-352796-6einbent 161 12 and and CC cord-352796-6einbent 161 13 invasion invasion NN cord-352796-6einbent 161 14 can can MD cord-352796-6einbent 161 15 be be VB cord-352796-6einbent 161 16 used use VBN cord-352796-6einbent 161 17 to to TO cord-352796-6einbent 161 18 provide provide VB cord-352796-6einbent 161 19 protection protection NN cord-352796-6einbent 161 20 that that WDT cord-352796-6einbent 161 21 is be VBZ cord-352796-6einbent 161 22 likely likely JJ cord-352796-6einbent 161 23 to to TO cord-352796-6einbent 161 24 be be VB cord-352796-6einbent 161 25 safe safe JJ cord-352796-6einbent 161 26 , , , cord-352796-6einbent 161 27 extensive extensive JJ cord-352796-6einbent 161 28 , , , cord-352796-6einbent 161 29 convenient convenient JJ cord-352796-6einbent 161 30 and and CC cord-352796-6einbent 161 31 at at IN cord-352796-6einbent 161 32 low low JJ cord-352796-6einbent 161 33 cost cost NN cord-352796-6einbent 161 34 . . . cord-352796-6einbent 162 1 The the DT cord-352796-6einbent 162 2 ocular ocular JJ cord-352796-6einbent 162 3 surface surface NN cord-352796-6einbent 162 4 , , , cord-352796-6einbent 162 5 offering offer VBG cord-352796-6einbent 162 6 all all DT cord-352796-6einbent 162 7 of of IN cord-352796-6einbent 162 8 the the DT cord-352796-6einbent 162 9 benefits benefit NNS cord-352796-6einbent 162 10 of of IN cord-352796-6einbent 162 11 local local JJ cord-352796-6einbent 162 12 treatment treatment NN cord-352796-6einbent 162 13 familiar familiar JJ cord-352796-6einbent 162 14 to to IN cord-352796-6einbent 162 15 ophthalmologists ophthalmologist NNS cord-352796-6einbent 162 16 , , , cord-352796-6einbent 162 17 may may MD cord-352796-6einbent 162 18 thus thus RB cord-352796-6einbent 162 19 provide provide VB cord-352796-6einbent 162 20 a a DT cord-352796-6einbent 162 21 convenient convenient JJ cord-352796-6einbent 162 22 testing testing NN cord-352796-6einbent 162 23 ground ground NN cord-352796-6einbent 162 24 for for IN cord-352796-6einbent 162 25 rapid rapid JJ cord-352796-6einbent 162 26 , , , cord-352796-6einbent 162 27 safe safe JJ cord-352796-6einbent 162 28 and and CC cord-352796-6einbent 162 29 likely likely JJ cord-352796-6einbent 162 30 cost cost NN cord-352796-6einbent 162 31 - - HYPH cord-352796-6einbent 162 32 effective effective JJ cord-352796-6einbent 162 33 trials trial NNS cord-352796-6einbent 162 34 of of IN cord-352796-6einbent 162 35 newer new JJR cord-352796-6einbent 162 36 drugs drug NNS cord-352796-6einbent 162 37 that that WDT cord-352796-6einbent 162 38 may may MD cord-352796-6einbent 162 39 be be VB cord-352796-6einbent 162 40 developed develop VBN cord-352796-6einbent 162 41 to to TO cord-352796-6einbent 162 42 combat combat VB cord-352796-6einbent 162 43 this this DT cord-352796-6einbent 162 44 modern modern JJ cord-352796-6einbent 162 45 plague plague NN cord-352796-6einbent 162 46 . . . cord-352796-6einbent 163 1 Table table NN cord-352796-6einbent 163 2 2 2 CD cord-352796-6einbent 163 3 . . . cord-352796-6einbent 163 4 _SP cord-352796-6einbent 164 1 Another another DT cord-352796-6einbent 164 2 Decade decade NN cord-352796-6einbent 164 3 , , , cord-352796-6einbent 164 4 Another another DT cord-352796-6einbent 164 5 Coronavirus Coronavirus NNP cord-352796-6einbent 164 6 Jia Jia NNP cord-352796-6einbent 164 7 Zhi Zhi NNP cord-352796-6einbent 164 8 - - HYPH cord-352796-6einbent 164 9 fang fang NNP cord-352796-6einbent 164 10 . . . cord-352796-6einbent 165 1 2019-nCoV 2019-ncov CD cord-352796-6einbent 165 2 transmission transmission NN cord-352796-6einbent 165 3 through through IN cord-352796-6einbent 165 4 the the DT cord-352796-6einbent 165 5 ocular ocular JJ cord-352796-6einbent 165 6 surface surface NN cord-352796-6einbent 165 7 must must MD cord-352796-6einbent 165 8 not not RB cord-352796-6einbent 165 9 be be VB cord-352796-6einbent 165 10 ignored ignore VBN cord-352796-6einbent 165 11 . . . cord-352796-6einbent 166 1 The the DT cord-352796-6einbent 166 2 Lancet Lancet NNP cord-352796-6einbent 167 1 The the DT cord-352796-6einbent 167 2 transmission transmission NN cord-352796-6einbent 167 3 of of IN cord-352796-6einbent 167 4 infection infection NN cord-352796-6einbent 167 5 through through IN cord-352796-6einbent 167 6 the the DT cord-352796-6einbent 167 7 eye eye NN cord-352796-6einbent 167 8 Ocular ocular JJ cord-352796-6einbent 167 9 tropism tropism NN cord-352796-6einbent 167 10 of of IN cord-352796-6einbent 167 11 respiratory respiratory JJ cord-352796-6einbent 167 12 viruses virus NNS cord-352796-6einbent 168 1 The the DT cord-352796-6einbent 168 2 eyes eye NNS cord-352796-6einbent 168 3 have have VBP cord-352796-6einbent 168 4 it -PRON- PRP cord-352796-6einbent 168 5 : : : cord-352796-6einbent 168 6 influenza influenza NN cord-352796-6einbent 168 7 virus virus NN cord-352796-6einbent 168 8 infection infection NN cord-352796-6einbent 168 9 beyond beyond IN cord-352796-6einbent 168 10 the the DT cord-352796-6einbent 168 11 respiratory respiratory JJ cord-352796-6einbent 168 12 tract tract NN cord-352796-6einbent 168 13 Pathogenesis pathogenesis NN cord-352796-6einbent 168 14 , , , cord-352796-6einbent 168 15 transmissibility transmissibility NN cord-352796-6einbent 168 16 , , , cord-352796-6einbent 168 17 and and CC cord-352796-6einbent 168 18 ocular ocular JJ cord-352796-6einbent 168 19 tropism tropism NN cord-352796-6einbent 168 20 of of IN cord-352796-6einbent 168 21 a a DT cord-352796-6einbent 168 22 highly highly RB cord-352796-6einbent 168 23 pathogenic pathogenic JJ cord-352796-6einbent 168 24 avian avian JJ cord-352796-6einbent 168 25 influenza influenza NN cord-352796-6einbent 168 26 A a NN cord-352796-6einbent 168 27 ( ( -LRB- cord-352796-6einbent 168 28 H7N3 H7N3 NNP cord-352796-6einbent 168 29 ) ) -RRB- cord-352796-6einbent 168 30 virus virus NN cord-352796-6einbent 168 31 associated associate VBN cord-352796-6einbent 168 32 with with IN cord-352796-6einbent 168 33 human human JJ cord-352796-6einbent 168 34 conjunctivitis conjunctivitis NN cord-352796-6einbent 168 35 Sialic Sialic NNP cord-352796-6einbent 168 36 Acid Acid NNP cord-352796-6einbent 168 37 - - HYPH cord-352796-6einbent 168 38 Containing contain VBG cord-352796-6einbent 168 39 Glycans Glycans NNPS cord-352796-6einbent 168 40 as as IN cord-352796-6einbent 168 41 Cellular Cellular NNP cord-352796-6einbent 168 42 Receptors Receptors NNPS cord-352796-6einbent 168 43 for for IN cord-352796-6einbent 168 44 Ocular Ocular NNP cord-352796-6einbent 168 45 Human Human NNP cord-352796-6einbent 168 46 Adenoviruses Adenoviruses NNPS cord-352796-6einbent 168 47 : : : cord-352796-6einbent 168 48 Implications implication NNS cord-352796-6einbent 168 49 for for IN cord-352796-6einbent 168 50 Tropism tropism NN cord-352796-6einbent 168 51 and and CC cord-352796-6einbent 168 52 Treatment Treatment NNP cord-352796-6einbent 168 53 Eye Eye NNP cord-352796-6einbent 168 54 hospital hospital NN cord-352796-6einbent 168 55 eye eye NN cord-352796-6einbent 168 56 Initial initial JJ cord-352796-6einbent 168 57 viral viral JJ cord-352796-6einbent 168 58 load load NN cord-352796-6einbent 168 59 and and CC cord-352796-6einbent 168 60 the the DT cord-352796-6einbent 168 61 outcomes outcome NNS cord-352796-6einbent 168 62 of of IN cord-352796-6einbent 168 63 SARS SARS NNP cord-352796-6einbent 169 1 The the DT cord-352796-6einbent 169 2 history history NN cord-352796-6einbent 169 3 of of IN cord-352796-6einbent 169 4 optical optical JJ cord-352796-6einbent 169 5 instruments instrument NNS cord-352796-6einbent 169 6 for for IN cord-352796-6einbent 169 7 the the DT cord-352796-6einbent 169 8 examination examination NN cord-352796-6einbent 169 9 of of IN cord-352796-6einbent 169 10 the the DT cord-352796-6einbent 169 11 eye eye NN cord-352796-6einbent 169 12 Dispersal Dispersal NNP cord-352796-6einbent 169 13 of of IN cord-352796-6einbent 169 14 exhaled exhale VBN cord-352796-6einbent 169 15 air air NN cord-352796-6einbent 169 16 and and CC cord-352796-6einbent 169 17 personal personal JJ cord-352796-6einbent 169 18 exposure exposure NN cord-352796-6einbent 169 19 in in IN cord-352796-6einbent 169 20 displacement displacement NN cord-352796-6einbent 169 21 ventilated ventilate VBN cord-352796-6einbent 169 22 rooms room NNS cord-352796-6einbent 169 23 Slit slit JJ cord-352796-6einbent 169 24 lamps lamp NNS cord-352796-6einbent 169 25 and and CC cord-352796-6einbent 169 26 lenses lense NNS cord-352796-6einbent 169 27 : : : cord-352796-6einbent 169 28 a a DT cord-352796-6einbent 169 29 potential potential JJ cord-352796-6einbent 169 30 source source NN cord-352796-6einbent 169 31 of of IN cord-352796-6einbent 169 32 nosocomial nosocomial JJ cord-352796-6einbent 169 33 infections infection NNS cord-352796-6einbent 169 34 ? ? . cord-352796-6einbent 170 1 Eye eye JJ cord-352796-6einbent 170 2 Outbreak outbreak NN cord-352796-6einbent 170 3 of of IN cord-352796-6einbent 170 4 Epidemic Epidemic NNP cord-352796-6einbent 170 5 Keratoconjunctivitis Keratoconjunctivitis NNP cord-352796-6einbent 170 6 Caused cause VBN cord-352796-6einbent 170 7 by by IN cord-352796-6einbent 170 8 Human Human NNP cord-352796-6einbent 170 9 Adenovirus Adenovirus NNP cord-352796-6einbent 170 10 Type Type NNP cord-352796-6einbent 170 11 D53 D53 NNP cord-352796-6einbent 170 12 in in IN cord-352796-6einbent 170 13 an an DT cord-352796-6einbent 170 14 Eye Eye NNP cord-352796-6einbent 170 15 Care Care NNP cord-352796-6einbent 170 16 Clinic Clinic NNP cord-352796-6einbent 170 17 -Los -los XX cord-352796-6einbent 170 18 Angeles Angeles NNP cord-352796-6einbent 170 19 County County NNP cord-352796-6einbent 170 20 Frequency Frequency NNP cord-352796-6einbent 170 21 and and CC cord-352796-6einbent 170 22 assortment assortment NN cord-352796-6einbent 170 23 of of IN cord-352796-6einbent 170 24 self self NN cord-352796-6einbent 170 25 - - HYPH cord-352796-6einbent 170 26 report report NN cord-352796-6einbent 170 27 occupational occupational JJ cord-352796-6einbent 170 28 complaints complaint NNS cord-352796-6einbent 170 29 among among IN cord-352796-6einbent 170 30 Iranian iranian JJ cord-352796-6einbent 170 31 ophthalmologists ophthalmologist NNS cord-352796-6einbent 170 32 : : : cord-352796-6einbent 170 33 a a DT cord-352796-6einbent 170 34 preliminary preliminary JJ cord-352796-6einbent 170 35 survey survey NN cord-352796-6einbent 171 1 The the DT cord-352796-6einbent 171 2 prevalence prevalence NN cord-352796-6einbent 171 3 of of IN cord-352796-6einbent 171 4 adenoviral adenoviral JJ cord-352796-6einbent 171 5 conjunctivitis conjunctivitis NN cord-352796-6einbent 171 6 in in IN cord-352796-6einbent 171 7 Tikrit Tikrit NNP cord-352796-6einbent 171 8 district district NN cord-352796-6einbent 171 9 and and CC cord-352796-6einbent 171 10 the the DT cord-352796-6einbent 171 11 role role NN cord-352796-6einbent 171 12 of of IN cord-352796-6einbent 171 13 traditional traditional JJ cord-352796-6einbent 171 14 medicine medicine NN cord-352796-6einbent 171 15 " " '' cord-352796-6einbent 171 16 OM OM NNP cord-352796-6einbent 171 17 AL AL NNP cord-352796-6einbent 171 18 KAASH KAASH NNP cord-352796-6einbent 171 19 " " '' cord-352796-6einbent 171 20 in in IN cord-352796-6einbent 171 21 transmission transmission NN cord-352796-6einbent 171 22 of of IN cord-352796-6einbent 171 23 the the DT cord-352796-6einbent 171 24 disease disease NN cord-352796-6einbent 171 25 and and CC cord-352796-6einbent 171 26 in in IN cord-352796-6einbent 171 27 the the DT cord-352796-6einbent 171 28 severity severity NN cord-352796-6einbent 171 29 of of IN cord-352796-6einbent 171 30 complications complication NNS cord-352796-6einbent 171 31 Precautions precaution NNS cord-352796-6einbent 171 32 in in IN cord-352796-6einbent 171 33 ophthalmic ophthalmic JJ cord-352796-6einbent 171 34 practice practice NN cord-352796-6einbent 171 35 in in IN cord-352796-6einbent 171 36 a a DT cord-352796-6einbent 171 37 hospital hospital NN cord-352796-6einbent 171 38 with with IN cord-352796-6einbent 171 39 a a DT cord-352796-6einbent 171 40 major major JJ cord-352796-6einbent 171 41 acute acute JJ cord-352796-6einbent 171 42 SARS SARS NNP cord-352796-6einbent 171 43 outbreak outbreak NN cord-352796-6einbent 171 44 : : : cord-352796-6einbent 171 45 an an DT cord-352796-6einbent 171 46 experience experience NN cord-352796-6einbent 171 47 from from IN cord-352796-6einbent 171 48 Hong Hong NNP cord-352796-6einbent 171 49 Kong Kong NNP cord-352796-6einbent 171 50 Novel Novel NNP cord-352796-6einbent 171 51 Coronavirus Coronavirus NNP cord-352796-6einbent 171 52 disease disease NN cord-352796-6einbent 171 53 2019 2019 CD cord-352796-6einbent 171 54 ( ( -LRB- cord-352796-6einbent 171 55 COVID-19 COVID-19 NNP cord-352796-6einbent 171 56 ) ) -RRB- cord-352796-6einbent 171 57 : : : cord-352796-6einbent 171 58 The the DT cord-352796-6einbent 171 59 importance importance NN cord-352796-6einbent 171 60 of of IN cord-352796-6einbent 171 61 recognising recognise VBG cord-352796-6einbent 171 62 possible possible JJ cord-352796-6einbent 171 63 early early JJ cord-352796-6einbent 171 64 ocular ocular JJ cord-352796-6einbent 171 65 manifestation manifestation NN cord-352796-6einbent 171 66 and and CC cord-352796-6einbent 171 67 using use VBG cord-352796-6einbent 171 68 protective protective JJ cord-352796-6einbent 171 69 eyewear eyewear NN cord-352796-6einbent 171 70 Early Early NNP cord-352796-6einbent 171 71 Transmission Transmission NNP cord-352796-6einbent 171 72 Dynamics Dynamics NNPS cord-352796-6einbent 171 73 in in IN cord-352796-6einbent 171 74 Wuhan Wuhan NNP cord-352796-6einbent 171 75 , , , cord-352796-6einbent 171 76 China China NNP cord-352796-6einbent 171 77 , , , cord-352796-6einbent 171 78 of of IN cord-352796-6einbent 171 79 Novel Novel NNP cord-352796-6einbent 171 80 Coronavirus Coronavirus NNP cord-352796-6einbent 171 81 - - HYPH cord-352796-6einbent 171 82 Infected Infected NNP cord-352796-6einbent 171 83 Pneumonia Pneumonia NNP cord-352796-6einbent 171 84 Transmission Transmission NNP cord-352796-6einbent 171 85 routes route NNS cord-352796-6einbent 171 86 of of IN cord-352796-6einbent 171 87 2019-nCoV 2019-ncov CD cord-352796-6einbent 171 88 and and CC cord-352796-6einbent 171 89 controls control NNS cord-352796-6einbent 171 90 in in IN cord-352796-6einbent 171 91 dental dental JJ cord-352796-6einbent 171 92 practice practice NN cord-352796-6einbent 171 93 WHO who WP cord-352796-6einbent 171 94 | | VBZ cord-352796-6einbent 171 95 Update update NN cord-352796-6einbent 171 96 27 27 CD cord-352796-6einbent 171 97 -One -one NN cord-352796-6einbent 171 98 month month NN cord-352796-6einbent 171 99 into into IN cord-352796-6einbent 171 100 the the DT cord-352796-6einbent 171 101 global global JJ cord-352796-6einbent 171 102 SARS SARS NNP cord-352796-6einbent 171 103 outbreak outbreak NN cord-352796-6einbent 171 104 : : : cord-352796-6einbent 171 105 Status status NN cord-352796-6einbent 171 106 of of IN cord-352796-6einbent 171 107 the the DT cord-352796-6einbent 171 108 outbreak outbreak NN cord-352796-6einbent 171 109 and and CC cord-352796-6einbent 171 110 lessons lesson NNS cord-352796-6einbent 171 111 for for IN cord-352796-6einbent 171 112 the the DT cord-352796-6einbent 171 113 immediate immediate JJ cord-352796-6einbent 171 114 future future NN cord-352796-6einbent 171 115 Accessed Accessed NNP cord-352796-6einbent 171 116 Recognition Recognition NNP cord-352796-6einbent 171 117 of of IN cord-352796-6einbent 171 118 aerosol aerosol NN cord-352796-6einbent 171 119 transmission transmission NN cord-352796-6einbent 171 120 of of IN cord-352796-6einbent 171 121 infectious infectious JJ cord-352796-6einbent 171 122 agents agent NNS cord-352796-6einbent 171 123 : : : cord-352796-6einbent 171 124 a a DT cord-352796-6einbent 171 125 commentary commentary NN cord-352796-6einbent 171 126 The the DT cord-352796-6einbent 171 127 exposed expose VBN cord-352796-6einbent 171 128 ocular ocular JJ cord-352796-6einbent 171 129 surface surface NN cord-352796-6einbent 171 130 and and CC cord-352796-6einbent 171 131 its -PRON- PRP$ cord-352796-6einbent 171 132 relationship relationship NN cord-352796-6einbent 171 133 to to IN cord-352796-6einbent 171 134 spontaneous spontaneous JJ cord-352796-6einbent 171 135 eyeblink eyeblink NN cord-352796-6einbent 171 136 rate rate NN cord-352796-6einbent 171 137 in in IN cord-352796-6einbent 171 138 elderly elderly JJ cord-352796-6einbent 171 139 caucasians caucasian NNS cord-352796-6einbent 171 140 Ocular ocular JJ cord-352796-6einbent 171 141 surface surface NN cord-352796-6einbent 171 142 area area NN cord-352796-6einbent 171 143 as as IN cord-352796-6einbent 171 144 an an DT cord-352796-6einbent 171 145 informative informative JJ cord-352796-6einbent 171 146 index index NN cord-352796-6einbent 171 147 of of IN cord-352796-6einbent 171 148 visual visual JJ cord-352796-6einbent 171 149 ergonomics ergonomic NNS cord-352796-6einbent 171 150 On on IN cord-352796-6einbent 171 151 the the DT cord-352796-6einbent 171 152 size size NN cord-352796-6einbent 171 153 of of IN cord-352796-6einbent 171 154 the the DT cord-352796-6einbent 171 155 conjunctival conjunctival NN cord-352796-6einbent 171 156 sac sac NN cord-352796-6einbent 171 157 Comparison comparison NN cord-352796-6einbent 171 158 of of IN cord-352796-6einbent 171 159 conjunctival conjunctival NN cord-352796-6einbent 171 160 and and CC cord-352796-6einbent 171 161 corneal corneal JJ cord-352796-6einbent 171 162 surface surface NN cord-352796-6einbent 171 163 areas area NNS cord-352796-6einbent 171 164 in in IN cord-352796-6einbent 171 165 rabbit rabbit NN cord-352796-6einbent 171 166 and and CC cord-352796-6einbent 171 167 human human JJ cord-352796-6einbent 171 168 Migration migration NN cord-352796-6einbent 171 169 of of IN cord-352796-6einbent 171 170 Cosmetic cosmetic JJ cord-352796-6einbent 171 171 Products product NNS cord-352796-6einbent 171 172 into into IN cord-352796-6einbent 171 173 the the DT cord-352796-6einbent 171 174 Tear Tear NNP cord-352796-6einbent 171 175 Film Film NNP cord-352796-6einbent 171 176 Supracutaneous Supracutaneous NNP cord-352796-6einbent 171 177 treatment treatment NN cord-352796-6einbent 171 178 of of IN cord-352796-6einbent 171 179 dry dry JJ cord-352796-6einbent 171 180 eye eye NN cord-352796-6einbent 171 181 patients patient NNS cord-352796-6einbent 171 182 with with IN cord-352796-6einbent 171 183 calcium calcium NN cord-352796-6einbent 171 184 carbonate carbonate NN cord-352796-6einbent 171 185 New new JJ cord-352796-6einbent 171 186 treatment treatment NN cord-352796-6einbent 171 187 of of IN cord-352796-6einbent 171 188 dry dry JJ cord-352796-6einbent 171 189 eye eye NN cord-352796-6einbent 171 190 : : : cord-352796-6einbent 171 191 the the DT cord-352796-6einbent 171 192 effect effect NN cord-352796-6einbent 171 193 of of IN cord-352796-6einbent 171 194 calcium calcium NN cord-352796-6einbent 171 195 ointment ointment NN cord-352796-6einbent 171 196 through through IN cord-352796-6einbent 171 197 eyelid eyelid NN cord-352796-6einbent 171 198 skin skin NN cord-352796-6einbent 171 199 delivery delivery NN cord-352796-6einbent 171 200 Evaluation Evaluation NNP cord-352796-6einbent 171 201 of of IN cord-352796-6einbent 171 202 Eyeball Eyeball NNP cord-352796-6einbent 171 203 and and CC cord-352796-6einbent 171 204 Orbit Orbit NNP cord-352796-6einbent 171 205 in in IN cord-352796-6einbent 171 206 Relation Relation NNP cord-352796-6einbent 171 207 to to IN cord-352796-6einbent 171 208 Gender Gender NNP cord-352796-6einbent 171 209 and and CC cord-352796-6einbent 171 210 Age Age NNP cord-352796-6einbent 171 211 Morphometric Morphometric NNP cord-352796-6einbent 171 212 Analysis Analysis NNP cord-352796-6einbent 171 213 of of IN cord-352796-6einbent 171 214 the the DT cord-352796-6einbent 171 215 Orbital orbital JJ cord-352796-6einbent 171 216 Aperture Aperture NNP cord-352796-6einbent 171 217 in in IN cord-352796-6einbent 171 218 North North NNP cord-352796-6einbent 171 219 Indian Indian NNP cord-352796-6einbent 171 220 Population Population NNP cord-352796-6einbent 171 221 : : : cord-352796-6einbent 172 1 A a DT cord-352796-6einbent 172 2 Retrospective Retrospective NNP cord-352796-6einbent 172 3 Digital Digital NNP cord-352796-6einbent 172 4 Forensic Forensic NNP cord-352796-6einbent 172 5 Study Study NNP cord-352796-6einbent 172 6 Eyelashes eyelash NNS cord-352796-6einbent 172 7 divert divert VBP cord-352796-6einbent 172 8 airflow airflow NN cord-352796-6einbent 172 9 to to TO cord-352796-6einbent 172 10 protect protect VB cord-352796-6einbent 172 11 the the DT cord-352796-6einbent 172 12 eye eye NN cord-352796-6einbent 172 13 Ethnic ethnic JJ cord-352796-6einbent 172 14 characteristics characteristic NNS cord-352796-6einbent 172 15 of of IN cord-352796-6einbent 172 16 eyelashes eyelash NNS cord-352796-6einbent 172 17 : : : cord-352796-6einbent 172 18 a a DT cord-352796-6einbent 172 19 comparative comparative JJ cord-352796-6einbent 172 20 analysis analysis NN cord-352796-6einbent 172 21 in in IN cord-352796-6einbent 172 22 Asian asian JJ cord-352796-6einbent 172 23 and and CC cord-352796-6einbent 172 24 Caucasian caucasian JJ cord-352796-6einbent 172 25 females female NNS cord-352796-6einbent 172 26 Identification Identification NNP cord-352796-6einbent 172 27 of of IN cord-352796-6einbent 172 28 nucleolin nucleolin NNP cord-352796-6einbent 172 29 as as IN cord-352796-6einbent 172 30 a a DT cord-352796-6einbent 172 31 cellular cellular JJ cord-352796-6einbent 172 32 receptor receptor NN cord-352796-6einbent 172 33 for for IN cord-352796-6einbent 172 34 human human JJ cord-352796-6einbent 172 35 respiratory respiratory JJ cord-352796-6einbent 172 36 syncytial syncytial JJ cord-352796-6einbent 172 37 virus virus NN cord-352796-6einbent 172 38 Evolution evolution NN cord-352796-6einbent 172 39 of of IN cord-352796-6einbent 172 40 the the DT cord-352796-6einbent 172 41 novel novel JJ cord-352796-6einbent 172 42 coronavirus coronavirus NN cord-352796-6einbent 172 43 from from IN cord-352796-6einbent 172 44 the the DT cord-352796-6einbent 172 45 ongoing ongoing JJ cord-352796-6einbent 172 46 Wuhan Wuhan NNP cord-352796-6einbent 172 47 outbreak outbreak NN cord-352796-6einbent 172 48 and and CC cord-352796-6einbent 172 49 modeling modeling NN cord-352796-6einbent 172 50 of of IN cord-352796-6einbent 172 51 its -PRON- PRP$ cord-352796-6einbent 172 52 spike spike NN cord-352796-6einbent 172 53 protein protein NN cord-352796-6einbent 172 54 for for IN cord-352796-6einbent 172 55 risk risk NN cord-352796-6einbent 172 56 of of IN cord-352796-6einbent 172 57 human human JJ cord-352796-6einbent 172 58 transmission transmission NN cord-352796-6einbent 172 59 Single single JJ cord-352796-6einbent 172 60 - - HYPH cord-352796-6einbent 172 61 cell cell NN cord-352796-6einbent 172 62 RNA rna NN cord-352796-6einbent 172 63 expression expression NN cord-352796-6einbent 172 64 profiling profiling NN cord-352796-6einbent 172 65 of of IN cord-352796-6einbent 172 66 ACE2 ACE2 NNP cord-352796-6einbent 172 67 , , , cord-352796-6einbent 172 68 the the DT cord-352796-6einbent 172 69 putative putative JJ cord-352796-6einbent 172 70 receptor receptor NN cord-352796-6einbent 172 71 of of IN cord-352796-6einbent 172 72 Wuhan Wuhan NNP cord-352796-6einbent 172 73 Crystal Crystal NNP cord-352796-6einbent 172 74 structure structure NN cord-352796-6einbent 172 75 of of IN cord-352796-6einbent 172 76 NL63 NL63 NNP cord-352796-6einbent 172 77 respiratory respiratory JJ cord-352796-6einbent 172 78 coronavirus coronavirus NN cord-352796-6einbent 172 79 receptor receptor NN cord-352796-6einbent 172 80 - - HYPH cord-352796-6einbent 172 81 binding bind VBG cord-352796-6einbent 172 82 domain domain NN cord-352796-6einbent 172 83 complexed complexe VBN cord-352796-6einbent 172 84 with with IN cord-352796-6einbent 172 85 its -PRON- PRP$ cord-352796-6einbent 172 86 human human JJ cord-352796-6einbent 172 87 receptor receptor NN cord-352796-6einbent 173 1 The the DT cord-352796-6einbent 173 2 S S NNP cord-352796-6einbent 173 3 proteins protein NNS cord-352796-6einbent 173 4 of of IN cord-352796-6einbent 173 5 human human JJ cord-352796-6einbent 173 6 coronavirus coronavirus NN cord-352796-6einbent 173 7 NL63 NL63 NNP cord-352796-6einbent 173 8 and and CC cord-352796-6einbent 173 9 severe severe JJ cord-352796-6einbent 173 10 acute acute JJ cord-352796-6einbent 173 11 respiratory respiratory JJ cord-352796-6einbent 173 12 syndrome syndrome NN cord-352796-6einbent 173 13 coronavirus coronavirus NN cord-352796-6einbent 173 14 bind bind VBP cord-352796-6einbent 173 15 overlapping overlap VBG cord-352796-6einbent 173 16 regions region NNS cord-352796-6einbent 173 17 of of IN cord-352796-6einbent 174 1 ACE2 ACE2 NNP cord-352796-6einbent 174 2 A a DT cord-352796-6einbent 174 3 pneumonia pneumonia NN cord-352796-6einbent 174 4 outbreak outbreak NN cord-352796-6einbent 174 5 associated associate VBN cord-352796-6einbent 174 6 with with IN cord-352796-6einbent 174 7 a a DT cord-352796-6einbent 174 8 new new JJ cord-352796-6einbent 174 9 coronavirus coronavirus NN cord-352796-6einbent 174 10 of of IN cord-352796-6einbent 174 11 probable probable JJ cord-352796-6einbent 174 12 bat bat NN cord-352796-6einbent 174 13 origin origin NN cord-352796-6einbent 174 14 Tissue tissue NN cord-352796-6einbent 174 15 distribution distribution NN cord-352796-6einbent 174 16 of of IN cord-352796-6einbent 174 17 ACE2 ACE2 NNP cord-352796-6einbent 174 18 protein protein NN cord-352796-6einbent 174 19 , , , cord-352796-6einbent 174 20 the the DT cord-352796-6einbent 174 21 functional functional JJ cord-352796-6einbent 174 22 receptor receptor NN cord-352796-6einbent 174 23 for for IN cord-352796-6einbent 174 24 SARS SARS NNP cord-352796-6einbent 174 25 coronavirus coronavirus NN cord-352796-6einbent 174 26 . . . cord-352796-6einbent 175 1 A a DT cord-352796-6einbent 175 2 first first JJ cord-352796-6einbent 175 3 step step NN cord-352796-6einbent 175 4 in in IN cord-352796-6einbent 175 5 understanding understand VBG cord-352796-6einbent 175 6 SARS SARS NNP cord-352796-6einbent 175 7 pathogenesis pathogenesis NN cord-352796-6einbent 175 8 ACE2 ACE2 NNP cord-352796-6einbent 175 9 receptor receptor NN cord-352796-6einbent 175 10 expression expression NN cord-352796-6einbent 175 11 and and CC cord-352796-6einbent 175 12 severe severe JJ cord-352796-6einbent 175 13 acute acute JJ cord-352796-6einbent 175 14 respiratory respiratory JJ cord-352796-6einbent 175 15 syndrome syndrome NN cord-352796-6einbent 175 16 coronavirus coronavirus NN cord-352796-6einbent 175 17 infection infection NN cord-352796-6einbent 175 18 depend depend VBP cord-352796-6einbent 175 19 on on IN cord-352796-6einbent 175 20 differentiation differentiation NN cord-352796-6einbent 175 21 of of IN cord-352796-6einbent 175 22 human human JJ cord-352796-6einbent 175 23 airway airway NN cord-352796-6einbent 175 24 epithelia epithelium NNS cord-352796-6einbent 175 25 Immunohistochemical Immunohistochemical NNP cord-352796-6einbent 175 26 localization localization NN cord-352796-6einbent 175 27 of of IN cord-352796-6einbent 175 28 angiotensin angiotensin NN cord-352796-6einbent 175 29 - - HYPH cord-352796-6einbent 175 30 converting convert VBG cord-352796-6einbent 175 31 enzyme enzyme NN cord-352796-6einbent 175 32 , , , cord-352796-6einbent 175 33 angiotensin angiotensin NN cord-352796-6einbent 175 34 II II NNP cord-352796-6einbent 175 35 and and CC cord-352796-6einbent 175 36 AT1 AT1 NNP cord-352796-6einbent 175 37 receptor receptor NN cord-352796-6einbent 175 38 in in IN cord-352796-6einbent 175 39 human human JJ cord-352796-6einbent 175 40 ocular ocular JJ cord-352796-6einbent 175 41 tissues tissue NNS cord-352796-6einbent 176 1 SARS SARS NNP cord-352796-6einbent 176 2 - - HYPH cord-352796-6einbent 176 3 CoV-2 CoV-2 NNP cord-352796-6einbent 176 4 entry entry NN cord-352796-6einbent 176 5 factors factor NNS cord-352796-6einbent 176 6 are be VBP cord-352796-6einbent 176 7 highly highly RB cord-352796-6einbent 176 8 expressed express VBN cord-352796-6einbent 176 9 in in IN cord-352796-6einbent 176 10 nasal nasal JJ cord-352796-6einbent 176 11 epithelial epithelial JJ cord-352796-6einbent 176 12 cells cell NNS cord-352796-6einbent 176 13 together together RB cord-352796-6einbent 176 14 with with IN cord-352796-6einbent 176 15 innate innate JJ cord-352796-6einbent 176 16 immune immune JJ cord-352796-6einbent 176 17 genes gene NNS cord-352796-6einbent 176 18 Tropism tropism NN cord-352796-6einbent 176 19 , , , cord-352796-6einbent 176 20 replication replication NN cord-352796-6einbent 176 21 competence competence NN cord-352796-6einbent 176 22 , , , cord-352796-6einbent 176 23 and and CC cord-352796-6einbent 176 24 innate innate JJ cord-352796-6einbent 176 25 immune immune JJ cord-352796-6einbent 176 26 responses response NNS cord-352796-6einbent 176 27 of of IN cord-352796-6einbent 176 28 the the DT cord-352796-6einbent 176 29 coronavirus coronavirus NN cord-352796-6einbent 176 30 SARS SARS NNP cord-352796-6einbent 176 31 - - HYPH cord-352796-6einbent 176 32 CoV-2 CoV-2 NNP cord-352796-6einbent 176 33 in in IN cord-352796-6einbent 176 34 human human JJ cord-352796-6einbent 176 35 respiratory respiratory JJ cord-352796-6einbent 176 36 tract tract NN cord-352796-6einbent 176 37 and and CC cord-352796-6einbent 176 38 conjunctiva conjunctiva NN cord-352796-6einbent 176 39 : : : cord-352796-6einbent 176 40 an an DT cord-352796-6einbent 176 41 analysis analysis NN cord-352796-6einbent 176 42 in in IN cord-352796-6einbent 176 43 ex ex JJ cord-352796-6einbent 176 44 - - NN cord-352796-6einbent 176 45 vivo vivo JJ cord-352796-6einbent 176 46 and and CC cord-352796-6einbent 176 47 in in IN cord-352796-6einbent 176 48 - - HYPH cord-352796-6einbent 176 49 vitro vitro FW cord-352796-6einbent 176 50 cultures culture NNS cord-352796-6einbent 176 51 Identification identification NN cord-352796-6einbent 176 52 of of IN cord-352796-6einbent 176 53 a a DT cord-352796-6einbent 176 54 new new JJ cord-352796-6einbent 176 55 human human JJ cord-352796-6einbent 176 56 coronavirus coronavirus NN cord-352796-6einbent 176 57 Human human JJ cord-352796-6einbent 176 58 coronavirus coronavirus NN cord-352796-6einbent 177 1 NL63 NL63 NNP cord-352796-6einbent 177 2 , , , cord-352796-6einbent 177 3 France France NNP cord-352796-6einbent 177 4 Dry Dry NNP cord-352796-6einbent 177 5 Eye Eye NNP cord-352796-6einbent 177 6 Epidermal epidermal JJ cord-352796-6einbent 177 7 surface surface NN cord-352796-6einbent 177 8 lipids lipid NNS cord-352796-6einbent 177 9 Lipids lipid NNS cord-352796-6einbent 177 10 , , , cord-352796-6einbent 177 11 proteins protein NNS cord-352796-6einbent 177 12 and and CC cord-352796-6einbent 177 13 corneocyte corneocyte NNP cord-352796-6einbent 177 14 adhesion adhesion NN cord-352796-6einbent 177 15 Tear Tear NNP cord-352796-6einbent 177 16 film film NN cord-352796-6einbent 177 17 lipids lipid NNS cord-352796-6einbent 178 1 Common common JJ cord-352796-6einbent 178 2 Features feature NNS cord-352796-6einbent 178 3 of of IN cord-352796-6einbent 178 4 Enveloped Enveloped NNP cord-352796-6einbent 178 5 Viruses Viruses NNPS cord-352796-6einbent 178 6 and and CC cord-352796-6einbent 178 7 Implications implication NNS cord-352796-6einbent 178 8 for for IN cord-352796-6einbent 178 9 Immunogen Immunogen NNP cord-352796-6einbent 178 10 Design Design NNP cord-352796-6einbent 178 11 for for IN cord-352796-6einbent 178 12 Next Next NNP cord-352796-6einbent 178 13 - - HYPH cord-352796-6einbent 178 14 Generation generation NN cord-352796-6einbent 178 15 Vaccines Vaccines NNPS cord-352796-6einbent 178 16 Murine Murine NNP cord-352796-6einbent 178 17 coronavirus coronavirus NN cord-352796-6einbent 178 18 requires require VBZ cord-352796-6einbent 178 19 lipid lipid NN cord-352796-6einbent 178 20 rafts raft NNS cord-352796-6einbent 178 21 for for IN cord-352796-6einbent 178 22 virus virus NN cord-352796-6einbent 178 23 entry entry NN cord-352796-6einbent 178 24 and and CC cord-352796-6einbent 178 25 cell cell NN cord-352796-6einbent 178 26 - - HYPH cord-352796-6einbent 178 27 cell cell NN cord-352796-6einbent 178 28 fusion fusion NN cord-352796-6einbent 178 29 but but CC cord-352796-6einbent 178 30 not not RB cord-352796-6einbent 178 31 for for IN cord-352796-6einbent 178 32 virus virus NN cord-352796-6einbent 178 33 release release NN cord-352796-6einbent 178 34 Importance importance NN cord-352796-6einbent 178 35 of of IN cord-352796-6einbent 178 36 cholesterol cholesterol NN cord-352796-6einbent 178 37 - - HYPH cord-352796-6einbent 178 38 rich rich JJ cord-352796-6einbent 178 39 membrane membrane NN cord-352796-6einbent 178 40 microdomains microdomain NNS cord-352796-6einbent 178 41 in in IN cord-352796-6einbent 178 42 the the DT cord-352796-6einbent 178 43 interaction interaction NN cord-352796-6einbent 178 44 of of IN cord-352796-6einbent 178 45 the the DT cord-352796-6einbent 178 46 S S NNP cord-352796-6einbent 178 47 protein protein NN cord-352796-6einbent 178 48 of of IN cord-352796-6einbent 178 49 SARS SARS NNP cord-352796-6einbent 178 50 - - HYPH cord-352796-6einbent 178 51 coronavirus coronavirus NN cord-352796-6einbent 178 52 with with IN cord-352796-6einbent 178 53 the the DT cord-352796-6einbent 178 54 cellular cellular JJ cord-352796-6einbent 178 55 receptor receptor NN cord-352796-6einbent 178 56 angiotensin angiotensin NN cord-352796-6einbent 178 57 - - HYPH cord-352796-6einbent 178 58 converting convert VBG cord-352796-6einbent 178 59 enzyme enzyme NN cord-352796-6einbent 178 60 2 2 CD cord-352796-6einbent 178 61 Complexity complexity NN cord-352796-6einbent 178 62 of of IN cord-352796-6einbent 178 63 the the DT cord-352796-6einbent 178 64 tear tear JJ cord-352796-6einbent 178 65 film film NN cord-352796-6einbent 178 66 : : : cord-352796-6einbent 178 67 importance importance NN cord-352796-6einbent 178 68 in in IN cord-352796-6einbent 178 69 homeostasis homeostasis NN cord-352796-6einbent 178 70 and and CC cord-352796-6einbent 178 71 dysfunction dysfunction NN cord-352796-6einbent 178 72 during during IN cord-352796-6einbent 178 73 disease disease NNP cord-352796-6einbent 178 74 Evaluation Evaluation NNP cord-352796-6einbent 178 75 of of IN cord-352796-6einbent 178 76 coronavirus coronavirus NN cord-352796-6einbent 178 77 in in IN cord-352796-6einbent 178 78 tears tear NNS cord-352796-6einbent 178 79 and and CC cord-352796-6einbent 178 80 conjunctival conjunctival JJ cord-352796-6einbent 178 81 secretions secretion NNS cord-352796-6einbent 178 82 of of IN cord-352796-6einbent 178 83 patients patient NNS cord-352796-6einbent 178 84 with with IN cord-352796-6einbent 178 85 SARS SARS NNP cord-352796-6einbent 178 86 - - HYPH cord-352796-6einbent 178 87 CoV-2 CoV-2 NNP cord-352796-6einbent 178 88 infection infection NN cord-352796-6einbent 178 89 SARS SARS NNP cord-352796-6einbent 178 90 - - HYPH cord-352796-6einbent 178 91 CoV-2 CoV-2 NNP cord-352796-6einbent 178 92 Isolation isolation NN cord-352796-6einbent 178 93 From from IN cord-352796-6einbent 178 94 Ocular ocular JJ cord-352796-6einbent 178 95 Secretions secretion NNS cord-352796-6einbent 178 96 of of IN cord-352796-6einbent 178 97 a a DT cord-352796-6einbent 178 98 Patient Patient NNP cord-352796-6einbent 178 99 With with IN cord-352796-6einbent 178 100 COVID-19 COVID-19 NNP cord-352796-6einbent 178 101 in in IN cord-352796-6einbent 178 102 Italy Italy NNP cord-352796-6einbent 178 103 With with IN cord-352796-6einbent 178 104 Prolonged prolonged JJ cord-352796-6einbent 178 105 Viral Viral NNP cord-352796-6einbent 178 106 RNA RNA NNP cord-352796-6einbent 178 107 Detection Detection NNP cord-352796-6einbent 178 108 Ocular ocular JJ cord-352796-6einbent 178 109 manifestations manifestation NNS cord-352796-6einbent 178 110 of of IN cord-352796-6einbent 178 111 a a DT cord-352796-6einbent 178 112 hospitalised hospitalise VBN cord-352796-6einbent 178 113 patient patient NN cord-352796-6einbent 178 114 with with IN cord-352796-6einbent 178 115 confirmed confirm VBN cord-352796-6einbent 178 116 2019 2019 CD cord-352796-6einbent 178 117 novel novel NN cord-352796-6einbent 178 118 coronavirus coronavirus NN cord-352796-6einbent 178 119 disease disease NN cord-352796-6einbent 178 120 Functional functional JJ cord-352796-6einbent 178 121 anatomy anatomy NN cord-352796-6einbent 178 122 and and CC cord-352796-6einbent 178 123 immunological immunological JJ cord-352796-6einbent 178 124 interactions interaction NNS cord-352796-6einbent 178 125 of of IN cord-352796-6einbent 178 126 ocular ocular JJ cord-352796-6einbent 178 127 surface surface NN cord-352796-6einbent 178 128 and and CC cord-352796-6einbent 179 1 adnexa adnexa NNP cord-352796-6einbent 179 2 Nasolacrimal Nasolacrimal NNP cord-352796-6einbent 179 3 duct duct NN cord-352796-6einbent 179 4 closure closure NN cord-352796-6einbent 179 5 modulates modulate VBZ cord-352796-6einbent 179 6 ocular ocular JJ cord-352796-6einbent 179 7 mucosal mucosal JJ cord-352796-6einbent 179 8 and and CC cord-352796-6einbent 179 9 systemic systemic JJ cord-352796-6einbent 179 10 CD4(+ CD4(+ NNS cord-352796-6einbent 179 11 ) ) -RRB- cord-352796-6einbent 180 1 T t NN cord-352796-6einbent 180 2 - - HYPH cord-352796-6einbent 180 3 cell cell NN cord-352796-6einbent 180 4 responses response NNS cord-352796-6einbent 180 5 induced induce VBN cord-352796-6einbent 180 6 following follow VBG cord-352796-6einbent 180 7 topical topical JJ cord-352796-6einbent 180 8 ocular ocular JJ cord-352796-6einbent 180 9 or or CC cord-352796-6einbent 180 10 intranasal intranasal JJ cord-352796-6einbent 180 11 immunization immunization NN cord-352796-6einbent 180 12 Tears tear NNS cord-352796-6einbent 180 13 and and CC cord-352796-6einbent 180 14 conjunctival conjunctival NN cord-352796-6einbent 180 15 scrapings scraping NNS cord-352796-6einbent 180 16 for for IN cord-352796-6einbent 180 17 coronavirus coronavirus NN cord-352796-6einbent 180 18 in in IN cord-352796-6einbent 180 19 patients patient NNS cord-352796-6einbent 180 20 with with IN cord-352796-6einbent 180 21 SARS SARS NNP cord-352796-6einbent 180 22 Angiotensin Angiotensin NNP cord-352796-6einbent 180 23 receptor receptor NN cord-352796-6einbent 180 24 blockers blocker NNS cord-352796-6einbent 180 25 as as IN cord-352796-6einbent 180 26 tentative tentative JJ cord-352796-6einbent 180 27 SARS SARS NNP cord-352796-6einbent 180 28 - - HYPH cord-352796-6einbent 180 29 CoV-2 CoV-2 NNP cord-352796-6einbent 180 30 therapeutics therapeutic NNS cord-352796-6einbent 180 31 Coronaviruses Coronaviruses NNP cord-352796-6einbent 180 32 -drug -drug NNP cord-352796-6einbent 180 33 discovery discovery NN cord-352796-6einbent 180 34 and and CC cord-352796-6einbent 180 35 therapeutic therapeutic JJ cord-352796-6einbent 180 36 options option NNS cord-352796-6einbent 181 1 Angiotensin angiotensin NN cord-352796-6einbent 181 2 - - HYPH cord-352796-6einbent 181 3 converting convert VBG cord-352796-6einbent 181 4 enzyme enzyme NN cord-352796-6einbent 181 5 2 2 CD cord-352796-6einbent 181 6 is be VBZ cord-352796-6einbent 181 7 a a DT cord-352796-6einbent 181 8 functional functional JJ cord-352796-6einbent 181 9 receptor receptor NN cord-352796-6einbent 181 10 for for IN cord-352796-6einbent 181 11 the the DT cord-352796-6einbent 181 12 SARS SARS NNP cord-352796-6einbent 181 13 coronavirus coronavirus NN cord-352796-6einbent 182 1 The the DT cord-352796-6einbent 182 2 comparative comparative JJ cord-352796-6einbent 182 3 efficacy efficacy NN cord-352796-6einbent 182 4 and and CC cord-352796-6einbent 182 5 safety safety NN cord-352796-6einbent 182 6 of of IN cord-352796-6einbent 182 7 the the DT cord-352796-6einbent 182 8 angiotensin angiotensin NN cord-352796-6einbent 182 9 receptor receptor NN cord-352796-6einbent 182 10 blockers blocker NNS cord-352796-6einbent 182 11 in in IN cord-352796-6einbent 182 12 the the DT cord-352796-6einbent 182 13 management management NN cord-352796-6einbent 182 14 of of IN cord-352796-6einbent 182 15 hypertension hypertension NN cord-352796-6einbent 182 16 and and CC cord-352796-6einbent 182 17 other other JJ cord-352796-6einbent 182 18 cardiovascular cardiovascular JJ cord-352796-6einbent 182 19 diseases disease NNS cord-352796-6einbent 182 20 Crystal Crystal NNP cord-352796-6einbent 182 21 structure structure NN cord-352796-6einbent 182 22 of of IN cord-352796-6einbent 182 23 the the DT cord-352796-6einbent 182 24 human human JJ cord-352796-6einbent 182 25 angiotensin angiotensin NN cord-352796-6einbent 182 26 - - HYPH cord-352796-6einbent 182 27 converting convert VBG cord-352796-6einbent 182 28 enzyme enzyme NN cord-352796-6einbent 182 29 - - HYPH cord-352796-6einbent 182 30 lisinopril lisinopril NN cord-352796-6einbent 182 31 complex complex NN cord-352796-6einbent 182 32 A a DT cord-352796-6einbent 182 33 virus virus NN cord-352796-6einbent 182 34 - - HYPH cord-352796-6einbent 182 35 binding bind VBG cord-352796-6einbent 182 36 hot hot JJ cord-352796-6einbent 182 37 spot spot NN cord-352796-6einbent 182 38 on on IN cord-352796-6einbent 182 39 human human JJ cord-352796-6einbent 182 40 angiotensin angiotensin NN cord-352796-6einbent 182 41 - - HYPH cord-352796-6einbent 182 42 converting convert VBG cord-352796-6einbent 182 43 enzyme enzyme NN cord-352796-6einbent 182 44 2 2 CD cord-352796-6einbent 182 45 is be VBZ cord-352796-6einbent 182 46 critical critical JJ cord-352796-6einbent 182 47 for for IN cord-352796-6einbent 182 48 binding bind VBG cord-352796-6einbent 182 49 of of IN cord-352796-6einbent 182 50 two two CD cord-352796-6einbent 182 51 different different JJ cord-352796-6einbent 182 52 coronaviruses coronaviruse NNS cord-352796-6einbent 182 53 ACE2 ACE2 NNP cord-352796-6einbent 182 54 X x NN cord-352796-6einbent 182 55 - - NN cord-352796-6einbent 182 56 ray ray NN cord-352796-6einbent 182 57 structures structure NNS cord-352796-6einbent 182 58 reveal reveal VBP cord-352796-6einbent 182 59 a a DT cord-352796-6einbent 182 60 large large JJ cord-352796-6einbent 182 61 hingebending hingebending NN cord-352796-6einbent 182 62 motion motion NN cord-352796-6einbent 182 63 important important JJ cord-352796-6einbent 182 64 for for IN cord-352796-6einbent 182 65 inhibitor inhibitor NN cord-352796-6einbent 182 66 binding binding NN cord-352796-6einbent 182 67 and and CC cord-352796-6einbent 182 68 catalysis catalysis NN cord-352796-6einbent 182 69 Screening screening NN cord-352796-6einbent 182 70 of of IN cord-352796-6einbent 182 71 an an DT cord-352796-6einbent 182 72 FDA FDA NNP cord-352796-6einbent 182 73 - - HYPH cord-352796-6einbent 182 74 approved approve VBN cord-352796-6einbent 182 75 compound compound NN cord-352796-6einbent 182 76 library library NN cord-352796-6einbent 182 77 identifies identify VBZ cord-352796-6einbent 182 78 four four CD cord-352796-6einbent 182 79 small small JJ cord-352796-6einbent 182 80 - - HYPH cord-352796-6einbent 182 81 molecule molecule NN cord-352796-6einbent 182 82 inhibitors inhibitor NNS cord-352796-6einbent 182 83 of of IN cord-352796-6einbent 182 84 Middle Middle NNP cord-352796-6einbent 182 85 East East NNP cord-352796-6einbent 182 86 respiratory respiratory JJ cord-352796-6einbent 182 87 syndrome syndrome NN cord-352796-6einbent 182 88 coronavirus coronavirus NN cord-352796-6einbent 182 89 replication replication NN cord-352796-6einbent 182 90 in in IN cord-352796-6einbent 182 91 cell cell NN cord-352796-6einbent 182 92 culture culture NN cord-352796-6einbent 182 93 Remdesivir Remdesivir NNP cord-352796-6einbent 182 94 and and CC cord-352796-6einbent 182 95 chloroquine chloroquine NNP cord-352796-6einbent 183 1 effectively effectively RB cord-352796-6einbent 183 2 inhibit inhibit VB cord-352796-6einbent 183 3 the the DT cord-352796-6einbent 183 4 recently recently RB cord-352796-6einbent 183 5 emerged emerge VBN cord-352796-6einbent 183 6 novel novel JJ cord-352796-6einbent 183 7 coronavirus coronavirus NN cord-352796-6einbent 183 8 ( ( -LRB- cord-352796-6einbent 183 9 2019-nCoV 2019-ncov CD cord-352796-6einbent 183 10 ) ) -RRB- cord-352796-6einbent 183 11 in in IN cord-352796-6einbent 183 12 vitro vitro FW cord-352796-6einbent 183 13 Evaluation Evaluation NNP cord-352796-6einbent 183 14 of of IN cord-352796-6einbent 183 15 immunomodulators immunomodulator NNS cord-352796-6einbent 183 16 , , , cord-352796-6einbent 183 17 interferons interferon NNS cord-352796-6einbent 183 18 and and CC cord-352796-6einbent 183 19 known know VBN cord-352796-6einbent 183 20 in in IN cord-352796-6einbent 183 21 vitro vitro FW cord-352796-6einbent 183 22 SARS SARS NNP cord-352796-6einbent 183 23 - - HYPH cord-352796-6einbent 183 24 coV coV NNP cord-352796-6einbent 183 25 inhibitors inhibitor NNS cord-352796-6einbent 183 26 for for IN cord-352796-6einbent 183 27 inhibition inhibition NN cord-352796-6einbent 183 28 of of IN cord-352796-6einbent 183 29 SARS SARS NNP cord-352796-6einbent 183 30 - - HYPH cord-352796-6einbent 183 31 coV coV VBG cord-352796-6einbent 183 32 replication replication NN cord-352796-6einbent 183 33 in in IN cord-352796-6einbent 183 34 BALB BALB NNP cord-352796-6einbent 183 35 / / SYM cord-352796-6einbent 183 36 c c NN cord-352796-6einbent 183 37 mice mouse NNS cord-352796-6einbent 184 1 A a DT cord-352796-6einbent 184 2 Rapid Rapid NNP cord-352796-6einbent 184 3 Systematic Systematic NNP cord-352796-6einbent 184 4 Review Review NNP cord-352796-6einbent 184 5 of of IN cord-352796-6einbent 184 6 Clinical Clinical NNP cord-352796-6einbent 184 7 Trials trial NNS cord-352796-6einbent 184 8 Utilizing utilize VBG cord-352796-6einbent 184 9 Chloroquine Chloroquine NNP cord-352796-6einbent 184 10 and and CC cord-352796-6einbent 184 11 Hydroxychloroquine Hydroxychloroquine NNP cord-352796-6einbent 184 12 as as IN cord-352796-6einbent 184 13 a a DT cord-352796-6einbent 184 14 Treatment Treatment NNP cord-352796-6einbent 184 15 for for IN cord-352796-6einbent 184 16 COVID-19 COVID-19 NNP cord-352796-6einbent 184 17 Evaluation Evaluation NNP cord-352796-6einbent 184 18 of of IN cord-352796-6einbent 184 19 the the DT cord-352796-6einbent 184 20 effects effect NNS cord-352796-6einbent 184 21 of of IN cord-352796-6einbent 184 22 chloroquine chloroquine NN cord-352796-6einbent 184 23 phosphate phosphate NN cord-352796-6einbent 184 24 eye eye NN cord-352796-6einbent 184 25 drops drop NNS cord-352796-6einbent 184 26 in in IN cord-352796-6einbent 184 27 patients patient NNS cord-352796-6einbent 184 28 with with IN cord-352796-6einbent 184 29 dry dry JJ cord-352796-6einbent 184 30 eye eye NN cord-352796-6einbent 184 31 syndrome syndrome NN cord-352796-6einbent 184 32 Efficacy Efficacy NNP cord-352796-6einbent 184 33 and and CC cord-352796-6einbent 184 34 Safety Safety NNP cord-352796-6einbent 184 35 of of IN cord-352796-6einbent 184 36 Topical Topical NNP cord-352796-6einbent 184 37 Chloroquine Chloroquine NNP cord-352796-6einbent 184 38 in in IN cord-352796-6einbent 184 39 Mild mild JJ cord-352796-6einbent 184 40 to to IN cord-352796-6einbent 184 41 Moderate Moderate NNP cord-352796-6einbent 184 42 Dry Dry NNP cord-352796-6einbent 184 43 Eye Eye NNP cord-352796-6einbent 184 44 Disease Disease NNP cord-352796-6einbent 184 45 Clinical Clinical NNP cord-352796-6einbent 184 46 Pharmacology Pharmacology NNP cord-352796-6einbent 184 47 Perspectives Perspectives NNPS cord-352796-6einbent 184 48 on on IN cord-352796-6einbent 184 49 the the DT cord-352796-6einbent 184 50 Antiviral Antiviral NNP cord-352796-6einbent 184 51 Activity Activity NNP cord-352796-6einbent 184 52 of of IN cord-352796-6einbent 184 53 Azithromycin Azithromycin NNP cord-352796-6einbent 184 54 and and CC cord-352796-6einbent 184 55 Use Use NNP cord-352796-6einbent 184 56 in in IN cord-352796-6einbent 184 57 COVID-19 COVID-19 NNP cord-352796-6einbent 184 58 Review Review NNP cord-352796-6einbent 184 59 of of IN cord-352796-6einbent 184 60 Azithromycin Azithromycin NNP cord-352796-6einbent 184 61 Ophthalmic Ophthalmic NNP cord-352796-6einbent 184 62 1 1 CD cord-352796-6einbent 184 63 % % NN cord-352796-6einbent 184 64 Solution solution NN cord-352796-6einbent 184 65 ( ( -LRB- cord-352796-6einbent 184 66 AzaSite AzaSite NNP cord-352796-6einbent 184 67 ( ( -LRB- cord-352796-6einbent 184 68 ® ® NN cord-352796-6einbent 184 69 ) ) -RRB- cord-352796-6einbent 184 70 ) ) -RRB- cord-352796-6einbent 184 71 for for IN cord-352796-6einbent 184 72 the the DT cord-352796-6einbent 184 73 Treatment Treatment NNP cord-352796-6einbent 184 74 of of IN cord-352796-6einbent 184 75 Ocular Ocular NNP cord-352796-6einbent 184 76 Infections Infections NNPS cord-352796-6einbent 184 77 Elimination Elimination NNP cord-352796-6einbent 184 78 of of IN cord-352796-6einbent 184 79 active active JJ cord-352796-6einbent 184 80 trachoma trachoma NN cord-352796-6einbent 184 81 after after IN cord-352796-6einbent 184 82 two two CD cord-352796-6einbent 184 83 topical topical JJ cord-352796-6einbent 184 84 mass mass NN cord-352796-6einbent 184 85 treatments treatment NNS cord-352796-6einbent 184 86 with with IN cord-352796-6einbent 184 87 azithromycin azithromycin NNP cord-352796-6einbent 184 88 1.5 1.5 CD cord-352796-6einbent 184 89 % % NN cord-352796-6einbent 184 90 eye eye NN cord-352796-6einbent 184 91 drops drop VBZ cord-352796-6einbent 184 92 Corneal corneal JJ cord-352796-6einbent 184 93 pharmacokinetics pharmacokinetic NNS cord-352796-6einbent 184 94 of of IN cord-352796-6einbent 184 95 topically topically RB cord-352796-6einbent 184 96 applied apply VBN cord-352796-6einbent 184 97 azithromycin azithromycin NNP cord-352796-6einbent 184 98 and and CC cord-352796-6einbent 184 99 clarithromycin clarithromycin NNS cord-352796-6einbent 184 100 Effects effect NNS cord-352796-6einbent 184 101 of of IN cord-352796-6einbent 184 102 dehydration dehydration NN cord-352796-6einbent 184 103 on on IN cord-352796-6einbent 184 104 corneal corneal JJ cord-352796-6einbent 184 105 tissue tissue NN cord-352796-6einbent 184 106 absorption absorption NN cord-352796-6einbent 184 107 of of IN cord-352796-6einbent 184 108 topical topical JJ cord-352796-6einbent 184 109 azithromycin azithromycin NNS cord-352796-6einbent 184 110 in in IN cord-352796-6einbent 184 111 rabbits rabbit NNS cord-352796-6einbent 184 112 Zn(2 Zn(2 NNP cord-352796-6einbent 184 113 + + SYM cord-352796-6einbent 184 114 ) ) -RRB- cord-352796-6einbent 184 115 inhibits inhibit VBZ cord-352796-6einbent 184 116 coronavirus coronavirus NN cord-352796-6einbent 184 117 and and CC cord-352796-6einbent 184 118 arterivirus arterivirus NNP cord-352796-6einbent 184 119 RNA RNA NNP cord-352796-6einbent 184 120 polymerase polymerase NN cord-352796-6einbent 184 121 activity activity NN cord-352796-6einbent 184 122 in in IN cord-352796-6einbent 184 123 vitro vitro FW cord-352796-6einbent 184 124 and and CC cord-352796-6einbent 184 125 zinc zinc NN cord-352796-6einbent 184 126 ionophores ionophores NNP cord-352796-6einbent 184 127 block block VBP cord-352796-6einbent 184 128 the the DT cord-352796-6einbent 184 129 replication replication NN cord-352796-6einbent 184 130 of of IN cord-352796-6einbent 184 131 these these DT cord-352796-6einbent 184 132 viruses virus NNS cord-352796-6einbent 184 133 in in IN cord-352796-6einbent 184 134 cell cell NN cord-352796-6einbent 184 135 culture culture NN cord-352796-6einbent 184 136 Influence influence NN cord-352796-6einbent 184 137 of of IN cord-352796-6einbent 184 138 topical topical JJ cord-352796-6einbent 184 139 and and CC cord-352796-6einbent 184 140 oral oral JJ cord-352796-6einbent 184 141 zinc zinc NN cord-352796-6einbent 184 142 upon upon IN cord-352796-6einbent 184 143 corneal corneal JJ cord-352796-6einbent 184 144 wound wound NN cord-352796-6einbent 184 145 healing heal VBG cord-352796-6einbent 184 146 Influence influence NN cord-352796-6einbent 184 147 of of IN cord-352796-6einbent 184 148 local local JJ cord-352796-6einbent 184 149 antiseptics antiseptic NNS cord-352796-6einbent 184 150 on on IN cord-352796-6einbent 184 151 regeneration regeneration NN cord-352796-6einbent 184 152 of of IN cord-352796-6einbent 184 153 corneal corneal JJ cord-352796-6einbent 184 154 epithelium epithelium NN cord-352796-6einbent 184 155 of of IN cord-352796-6einbent 184 156 rabbits rabbit NNS cord-352796-6einbent 185 1 Chloroquine chloroquine NN cord-352796-6einbent 185 2 paradox paradox NN cord-352796-6einbent 185 3 may may MD cord-352796-6einbent 185 4 cause cause VB cord-352796-6einbent 185 5 more more JJR cord-352796-6einbent 185 6 damage damage NN cord-352796-6einbent 185 7 than than IN cord-352796-6einbent 185 8 help help NN cord-352796-6einbent 185 9 fight fight VB cord-352796-6einbent 185 10 COVID-19 COVID-19 NNP cord-352796-6einbent 185 11 Effects effect NNS cord-352796-6einbent 185 12 of of IN cord-352796-6einbent 185 13 chloroquine chloroquine NN cord-352796-6einbent 185 14 on on IN cord-352796-6einbent 185 15 viral viral JJ cord-352796-6einbent 185 16 infections infection NNS cord-352796-6einbent 185 17 : : : cord-352796-6einbent 185 18 an an DT cord-352796-6einbent 185 19 old old JJ cord-352796-6einbent 185 20 drug drug NN cord-352796-6einbent 185 21 against against IN cord-352796-6einbent 185 22 today today NN cord-352796-6einbent 185 23 's 's POS cord-352796-6einbent 185 24 diseases disease NNS cord-352796-6einbent 185 25 ? ? . cord-352796-6einbent 186 1 Chloroquine Chloroquine NNP cord-352796-6einbent 186 2 is be VBZ cord-352796-6einbent 186 3 a a DT cord-352796-6einbent 186 4 potent potent JJ cord-352796-6einbent 186 5 inhibitor inhibitor NN cord-352796-6einbent 186 6 of of IN cord-352796-6einbent 186 7 SARS SARS NNP cord-352796-6einbent 186 8 coronavirus coronavirus NN cord-352796-6einbent 186 9 infection infection NN cord-352796-6einbent 186 10 and and CC cord-352796-6einbent 186 11 spread spread VBN cord-352796-6einbent 186 12 In in FW cord-352796-6einbent 186 13 vitro vitro FW cord-352796-6einbent 186 14 inhibition inhibition NN cord-352796-6einbent 186 15 of of IN cord-352796-6einbent 186 16 severe severe JJ cord-352796-6einbent 186 17 acute acute JJ cord-352796-6einbent 186 18 respiratory respiratory JJ cord-352796-6einbent 186 19 syndrome syndrome NN cord-352796-6einbent 186 20 coronavirus coronavirus NN cord-352796-6einbent 186 21 by by IN cord-352796-6einbent 186 22 chloroquine chloroquine JJ cord-352796-6einbent 186 23 New new JJ cord-352796-6einbent 186 24 insights insight NNS cord-352796-6einbent 186 25 into into IN cord-352796-6einbent 186 26 the the DT cord-352796-6einbent 186 27 antiviral antiviral JJ cord-352796-6einbent 186 28 effects effect NNS cord-352796-6einbent 186 29 of of IN cord-352796-6einbent 186 30 chloroquine chloroquine NN cord-352796-6einbent 186 31 The the DT cord-352796-6einbent 186 32 anti anti JJ cord-352796-6einbent 186 33 - - JJ cord-352796-6einbent 186 34 viral viral JJ cord-352796-6einbent 186 35 facet facet NN cord-352796-6einbent 186 36 of of IN cord-352796-6einbent 186 37 anti anti JJ cord-352796-6einbent 186 38 - - JJ cord-352796-6einbent 186 39 rheumatic rheumatic JJ cord-352796-6einbent 186 40 drugs drug NNS cord-352796-6einbent 186 41 : : : cord-352796-6einbent 186 42 Lessons lesson NNS cord-352796-6einbent 186 43 from from IN cord-352796-6einbent 186 44 COVID-19 COVID-19 NNP cord-352796-6einbent 186 45 In in IN cord-352796-6einbent 186 46 Vitro Vitro NNP cord-352796-6einbent 186 47 Antiviral Antiviral NNP cord-352796-6einbent 186 48 Activity Activity NNP cord-352796-6einbent 186 49 and and CC cord-352796-6einbent 186 50 Projection Projection NNP cord-352796-6einbent 186 51 of of IN cord-352796-6einbent 186 52 Optimized Optimized NNP cord-352796-6einbent 186 53 Dosing Dosing NNP cord-352796-6einbent 186 54 Design Design NNP cord-352796-6einbent 186 55 of of IN cord-352796-6einbent 186 56 Hydroxychloroquine Hydroxychloroquine NNP cord-352796-6einbent 186 57 for for IN cord-352796-6einbent 186 58 the the DT cord-352796-6einbent 186 59 Treatment Treatment NNP cord-352796-6einbent 186 60 of of IN cord-352796-6einbent 186 61 Severe severe JJ cord-352796-6einbent 186 62 Acute acute JJ cord-352796-6einbent 186 63 Respiratory Respiratory NNP cord-352796-6einbent 186 64 Syndrome Syndrome NNP cord-352796-6einbent 186 65 Coronavirus Coronavirus NNP cord-352796-6einbent 186 66 2 2 CD cord-352796-6einbent 187 1 ( ( -LRB- cord-352796-6einbent 187 2 SARS SARS NNP cord-352796-6einbent 187 3 - - HYPH cord-352796-6einbent 187 4 CoV-2 CoV-2 NNP cord-352796-6einbent 187 5 ) ) -RRB- cord-352796-6einbent 187 6 Hydroxychloroquine Hydroxychloroquine NNP cord-352796-6einbent 187 7 , , , cord-352796-6einbent 187 8 a a DT cord-352796-6einbent 187 9 less less RBR cord-352796-6einbent 187 10 toxic toxic JJ cord-352796-6einbent 187 11 derivative derivative NN cord-352796-6einbent 187 12 of of IN cord-352796-6einbent 187 13 chloroquine chloroquine NN cord-352796-6einbent 187 14 , , , cord-352796-6einbent 187 15 is be VBZ cord-352796-6einbent 187 16 effective effective JJ cord-352796-6einbent 187 17 in in IN cord-352796-6einbent 187 18 inhibiting inhibit VBG cord-352796-6einbent 187 19 SARS SARS NNP cord-352796-6einbent 187 20 - - HYPH cord-352796-6einbent 187 21 CoV-2 CoV-2 NNP cord-352796-6einbent 187 22 infection infection NN cord-352796-6einbent 187 23 in in IN cord-352796-6einbent 187 24 vitro vitro FW cord-352796-6einbent 187 25 Clinical clinical JJ cord-352796-6einbent 187 26 and and CC cord-352796-6einbent 187 27 microbiological microbiological JJ cord-352796-6einbent 187 28 effect effect NN cord-352796-6einbent 187 29 of of IN cord-352796-6einbent 187 30 a a DT cord-352796-6einbent 187 31 combination combination NN cord-352796-6einbent 187 32 of of IN cord-352796-6einbent 187 33 hydroxychloroquine hydroxychloroquine NN cord-352796-6einbent 187 34 and and CC cord-352796-6einbent 187 35 azithromycin azithromycin NNP cord-352796-6einbent 187 36 in in IN cord-352796-6einbent 187 37 80 80 CD cord-352796-6einbent 188 1 COVID-19 covid-19 JJ cord-352796-6einbent 188 2 patients patient NNS cord-352796-6einbent 188 3 with with IN cord-352796-6einbent 188 4 at at RB cord-352796-6einbent 188 5 least least JJS cord-352796-6einbent 188 6 a a DT cord-352796-6einbent 188 7 six six CD cord-352796-6einbent 188 8 - - HYPH cord-352796-6einbent 188 9 day day NN cord-352796-6einbent 188 10 follow follow VB cord-352796-6einbent 188 11 up up RP cord-352796-6einbent 188 12 : : : cord-352796-6einbent 188 13 A a DT cord-352796-6einbent 188 14 pilot pilot NN cord-352796-6einbent 188 15 observational observational JJ cord-352796-6einbent 188 16 study study NN cord-352796-6einbent 189 1 The the DT cord-352796-6einbent 189 2 Effect Effect NNP cord-352796-6einbent 189 3 of of IN cord-352796-6einbent 189 4 Chloroquine Chloroquine NNP cord-352796-6einbent 189 5 Hydroxychloroquine Hydroxychloroquine NNP cord-352796-6einbent 189 6 retinopathy retinopathy NN cord-352796-6einbent 189 7 Macular Macular NNP cord-352796-6einbent 189 8 toxicity toxicity NN cord-352796-6einbent 189 9 after after IN cord-352796-6einbent 189 10 short short JJ cord-352796-6einbent 189 11 - - HYPH cord-352796-6einbent 189 12 term term NN cord-352796-6einbent 189 13 hydroxychloroquine hydroxychloroquine NN cord-352796-6einbent 189 14 therapy therapy NNP cord-352796-6einbent 189 15 Analysis Analysis NNP cord-352796-6einbent 189 16 of of IN cord-352796-6einbent 189 17 the the DT cord-352796-6einbent 189 18 ABCR ABCR NNP cord-352796-6einbent 189 19 ( ( -LRB- cord-352796-6einbent 189 20 ABCA4 ABCA4 NNS cord-352796-6einbent 189 21 ) ) -RRB- cord-352796-6einbent 189 22 gene gene NN cord-352796-6einbent 189 23 in in IN cord-352796-6einbent 189 24 4-aminoquinoline 4-aminoquinoline CD cord-352796-6einbent 189 25 retinopathy retinopathy NN cord-352796-6einbent 189 26 : : : cord-352796-6einbent 189 27 Is be VBZ cord-352796-6einbent 189 28 retinal retinal JJ cord-352796-6einbent 189 29 toxicity toxicity NN cord-352796-6einbent 189 30 by by IN cord-352796-6einbent 189 31 chloroquine chloroquine NN cord-352796-6einbent 189 32 and and CC cord-352796-6einbent 189 33 hydroxychloroquine hydroxychloroquine NN cord-352796-6einbent 189 34 related relate VBN cord-352796-6einbent 189 35 to to IN cord-352796-6einbent 189 36 Stargardt Stargardt NNP cord-352796-6einbent 189 37 disease disease NN cord-352796-6einbent 189 38 ? ? . cord-352796-6einbent 190 1 Therapeutic therapeutic JJ cord-352796-6einbent 190 2 use use NN cord-352796-6einbent 190 3 and and CC cord-352796-6einbent 190 4 safety safety NN cord-352796-6einbent 190 5 profile profile NN cord-352796-6einbent 190 6 in in IN cord-352796-6einbent 190 7 the the DT cord-352796-6einbent 190 8 management management NN cord-352796-6einbent 190 9 of of IN cord-352796-6einbent 190 10 osteoarthritis osteoarthritis NN cord-352796-6einbent 190 11 and and CC cord-352796-6einbent 190 12 rheumatoid rheumatoid NN cord-352796-6einbent 190 13 arthritis arthritis NN cord-352796-6einbent 191 1 Audo Audo NNP cord-352796-6einbent 191 2 I -PRON- PRP cord-352796-6einbent 191 3 ; ; : cord-352796-6einbent 191 4 DHU DHU NNP cord-352796-6einbent 191 5 Vision Vision NNP cord-352796-6einbent 191 6 Handicaps Handicaps NNP cord-352796-6einbent 191 7 task task NN cord-352796-6einbent 191 8 force force NN cord-352796-6einbent 191 9 rétine rétine NN cord-352796-6einbent 191 10 . . . cord-352796-6einbent 192 1 Différences Différences NNP cord-352796-6einbent 192 2 ethniques ethniques NNP cord-352796-6einbent 192 3 parmi parmi NNP cord-352796-6einbent 193 1 les les NNP cord-352796-6einbent 193 2 patients patient NNS cord-352796-6einbent 193 3 souffrant souffrant NNP cord-352796-6einbent 193 4 de de NNP cord-352796-6einbent 193 5 toxicité toxicité NNP cord-352796-6einbent 193 6 maculaire maculaire NNP cord-352796-6einbent 193 7 aux aux NNP cord-352796-6einbent 193 8 antipaludéens antipaludéens NNP cord-352796-6einbent 193 9 de de NNP cord-352796-6einbent 193 10 synthèse synthèse NNP cord-352796-6einbent 193 11 Chloroquine Chloroquine NNP cord-352796-6einbent 194 1 is be VBZ cord-352796-6einbent 194 2 a a DT cord-352796-6einbent 194 3 zinc zinc NN cord-352796-6einbent 194 4 ionophore ionophore IN cord-352796-6einbent 194 5 Zinc Zinc NNP cord-352796-6einbent 194 6 Salts salt NNS cord-352796-6einbent 195 1 Block Block NNP cord-352796-6einbent 195 2 Hepatitis Hepatitis NNP cord-352796-6einbent 195 3 E e NN cord-352796-6einbent 195 4 Virus virus NN cord-352796-6einbent 195 5 Replication replication NN cord-352796-6einbent 195 6 by by IN cord-352796-6einbent 195 7 Inhibiting inhibit VBG cord-352796-6einbent 195 8 the the DT cord-352796-6einbent 195 9 Activity Activity NNP cord-352796-6einbent 195 10 of of IN cord-352796-6einbent 195 11 Viral Viral NNP cord-352796-6einbent 195 12 RNA RNA NNP cord-352796-6einbent 195 13 - - HYPH cord-352796-6einbent 195 14 Dependent Dependent NNP cord-352796-6einbent 195 15 RNA RNA NNP cord-352796-6einbent 195 16 Polymerase Polymerase NNP cord-352796-6einbent 195 17 Improving improve VBG cord-352796-6einbent 195 18 the the DT cord-352796-6einbent 195 19 efficacy efficacy NN cord-352796-6einbent 195 20 of of IN cord-352796-6einbent 195 21 Chloroquine Chloroquine NNP cord-352796-6einbent 195 22 and and CC cord-352796-6einbent 195 23 Hydroxychloroquine Hydroxychloroquine NNP cord-352796-6einbent 195 24 against against IN cord-352796-6einbent 195 25 SARS SARS NNP cord-352796-6einbent 195 26 - - HYPH cord-352796-6einbent 195 27 CoV-2 CoV-2 NNP cord-352796-6einbent 195 28 may may MD cord-352796-6einbent 195 29 require require VB cord-352796-6einbent 195 30 Zinc Zinc NNP cord-352796-6einbent 195 31 additives additive NNS cord-352796-6einbent 196 1 -A -A . cord-352796-6einbent 197 1 better well JJR cord-352796-6einbent 197 2 synergy synergy NN cord-352796-6einbent 197 3 for for IN cord-352796-6einbent 197 4 future future NN cord-352796-6einbent 198 1 COVID-19 covid-19 VB cord-352796-6einbent 198 2 clinical clinical JJ cord-352796-6einbent 198 3 trials trial NNS cord-352796-6einbent 199 1 Chloroquine Chloroquine NNP cord-352796-6einbent 199 2 keratopathy keratopathy NNP cord-352796-6einbent 199 3 in in IN cord-352796-6einbent 199 4 chloroquine chloroquine NN cord-352796-6einbent 199 5 workers worker NNS cord-352796-6einbent 199 6 after after IN cord-352796-6einbent 199 7 topical topical JJ cord-352796-6einbent 199 8 dust dust NN cord-352796-6einbent 199 9 exponation exponation NN cord-352796-6einbent 199 10 . . . cord-352796-6einbent 200 1 A a DT cord-352796-6einbent 200 2 case case NN cord-352796-6einbent 200 3 report report NN cord-352796-6einbent 200 4 Topical topical JJ cord-352796-6einbent 200 5 ocular ocular JJ cord-352796-6einbent 200 6 hypotensive hypotensive JJ cord-352796-6einbent 200 7 effects effect NNS cord-352796-6einbent 200 8 of of IN cord-352796-6einbent 200 9 the the DT cord-352796-6einbent 200 10 novel novel JJ cord-352796-6einbent 200 11 angiotensin angiotensin NN cord-352796-6einbent 200 12 converting convert VBG cord-352796-6einbent 200 13 enzyme enzyme NN cord-352796-6einbent 200 14 inhibitor inhibitor NN cord-352796-6einbent 200 15 SCH SCH NNP cord-352796-6einbent 200 16 33861 33861 CD cord-352796-6einbent 200 17 in in IN cord-352796-6einbent 200 18 conscious conscious JJ cord-352796-6einbent 200 19 rabbits rabbit NNS cord-352796-6einbent 201 1 The the DT cord-352796-6einbent 201 2 comparative comparative JJ cord-352796-6einbent 201 3 pharmacology pharmacology NN cord-352796-6einbent 201 4 of of IN cord-352796-6einbent 201 5 angiotensin angiotensin NN cord-352796-6einbent 201 6 II II NNP cord-352796-6einbent 201 7 receptor receptor NN cord-352796-6einbent 201 8 antagonists antagonist NNS cord-352796-6einbent 201 9 Upregulation Upregulation NNP cord-352796-6einbent 201 10 of of IN cord-352796-6einbent 201 11 angiotensin angiotensin NN cord-352796-6einbent 201 12 - - HYPH cord-352796-6einbent 201 13 converting convert VBG cord-352796-6einbent 201 14 enzyme enzyme NN cord-352796-6einbent 201 15 2 2 CD cord-352796-6einbent 201 16 after after IN cord-352796-6einbent 201 17 myocardial myocardial JJ cord-352796-6einbent 201 18 infarction infarction NN cord-352796-6einbent 201 19 by by IN cord-352796-6einbent 201 20 blockade blockade NN cord-352796-6einbent 201 21 of of IN cord-352796-6einbent 201 22 angiotensin angiotensin NN cord-352796-6einbent 201 23 II II NNP cord-352796-6einbent 201 24 receptors receptor NNS cord-352796-6einbent 201 25 Clinical clinical JJ cord-352796-6einbent 201 26 features feature NNS cord-352796-6einbent 201 27 of of IN cord-352796-6einbent 201 28 deaths death NNS cord-352796-6einbent 201 29 in in IN cord-352796-6einbent 201 30 the the DT cord-352796-6einbent 201 31 novel novel JJ cord-352796-6einbent 201 32 coronavirus coronavirus NN cord-352796-6einbent 201 33 epidemic epidemic NN cord-352796-6einbent 201 34 in in IN cord-352796-6einbent 201 35 Epub Epub NNP cord-352796-6einbent 201 36 ahead ahead RB cord-352796-6einbent 201 37 of of IN cord-352796-6einbent 201 38 print print NN cord-352796-6einbent 201 39 Bioavailability Bioavailability NNP cord-352796-6einbent 201 40 of of IN cord-352796-6einbent 201 41 hydroxychloroquine hydroxychloroquine NN cord-352796-6einbent 201 42 tablets tablet NNS cord-352796-6einbent 201 43 in in IN cord-352796-6einbent 201 44 healthy healthy JJ cord-352796-6einbent 201 45 volunteers volunteer NNS cord-352796-6einbent 201 46 High high JJ cord-352796-6einbent 201 47 expression expression NN cord-352796-6einbent 201 48 of of IN cord-352796-6einbent 201 49 ACE2 ACE2 NNP cord-352796-6einbent 201 50 receptor receptor NN cord-352796-6einbent 201 51 of of IN cord-352796-6einbent 201 52 2019-nCoV 2019-ncov CD cord-352796-6einbent 201 53 on on IN cord-352796-6einbent 201 54 the the DT cord-352796-6einbent 201 55 epithelial epithelial JJ cord-352796-6einbent 201 56 cells cell NNS cord-352796-6einbent 201 57 of of IN cord-352796-6einbent 201 58 oral oral JJ cord-352796-6einbent 201 59 mucosa mucosa NN