id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-030504-442pnl5s	Sun, Haiyan	Molecular characteristics of the VP1 region of enterovirus 71 strains in China	2020-08-14		.txt	text/plain	3534	178	54	BACKGROUND: Enterovirus 71 (EV71) is the most commonly implicated causative agent of severe outbreaks of paediatric hand, foot, and mouth disease (HFMD).VP1 protein, a capsid protein of EV71, is responsible for the genotype of the virus and is essential for vaccine development and effectiveness. These results suggest that the genetic characteristics of the EV71-VP1 region should be continuously monitored, which is critical for epidemic control and vaccine design to prevent EV71 infection in children. In this study, the VP1 sequences of all EV71 viruses registered in Gen-Bank in China from 1996 to 2019 were collected, and the molecular characteristics of genes were analysed using bioinformatics software to provide a scientific basis for the prevention and control of HFMD epidemics. In this study, the amino acid at position 145 in most strains was found to be E, with an E145G/Q mutation rate of 6.63%, suggesting that the emergence of this mutation may result in a virus that is more likely to infect human lymphocytes.	./cache/cord-030504-442pnl5s.txt	./txt/cord-030504-442pnl5s.txt