id	sid	tid	token	lemma	pos
cord-030504-442pnl5s	1	1	key	key	NN
cord-030504-442pnl5s	1	2	:	:	:
cord-030504-442pnl5s	2	1	cord-030504	cord-030504	NNP
cord-030504-442pnl5s	2	2	-	-	HYPH
cord-030504-442pnl5s	2	3	442pnl5s	442pnl5s	CD
cord-030504-442pnl5s	2	4	authors	author	NNS
cord-030504-442pnl5s	2	5	:	:	:
cord-030504-442pnl5s	2	6	Sun	Sun	NNP
cord-030504-442pnl5s	2	7	,	,	,
cord-030504-442pnl5s	2	8	Haiyan	Haiyan	NNP
cord-030504-442pnl5s	2	9	;	;	:
cord-030504-442pnl5s	2	10	Gao	Gao	NNP
cord-030504-442pnl5s	2	11	,	,	,
cord-030504-442pnl5s	2	12	Min	Min	NNP
cord-030504-442pnl5s	2	13	;	;	:
cord-030504-442pnl5s	2	14	Cui	Cui	NNP
cord-030504-442pnl5s	2	15	,	,	,
cord-030504-442pnl5s	2	16	Dawei	Dawei	NNP
cord-030504-442pnl5s	2	17	title	title	NN
cord-030504-442pnl5s	2	18	:	:	:
cord-030504-442pnl5s	3	1	Molecular	molecular	JJ
cord-030504-442pnl5s	3	2	characteristics	characteristic	NNS
cord-030504-442pnl5s	3	3	of	of	IN
cord-030504-442pnl5s	3	4	the	the	DT
cord-030504-442pnl5s	3	5	VP1	VP1	NNP
cord-030504-442pnl5s	3	6	region	region	NN
cord-030504-442pnl5s	3	7	of	of	IN
cord-030504-442pnl5s	3	8	enterovirus	enterovirus	NN
cord-030504-442pnl5s	3	9	71	71	CD
cord-030504-442pnl5s	3	10	strains	strain	NNS
cord-030504-442pnl5s	3	11	in	in	IN
cord-030504-442pnl5s	3	12	China	China	NNP
cord-030504-442pnl5s	3	13	date	date	NN
cord-030504-442pnl5s	3	14	:	:	:
cord-030504-442pnl5s	3	15	2020	2020	CD
cord-030504-442pnl5s	3	16	-	-	HYPH
cord-030504-442pnl5s	3	17	08	08	CD
cord-030504-442pnl5s	3	18	-	-	SYM
cord-030504-442pnl5s	3	19	14	14	CD
cord-030504-442pnl5s	3	20	journal	journal	NN
cord-030504-442pnl5s	3	21	:	:	:
cord-030504-442pnl5s	4	1	Gut	gut	VB
cord-030504-442pnl5s	4	2	Pathog	Pathog	NNP
cord-030504-442pnl5s	4	3	DOI	doi	NN
cord-030504-442pnl5s	4	4	:	:	:
cord-030504-442pnl5s	5	1	10.1186	10.1186	CD
cord-030504-442pnl5s	5	2	/	/	SYM
cord-030504-442pnl5s	5	3	s13099	s13099	NN
cord-030504-442pnl5s	5	4	-	-	HYPH
cord-030504-442pnl5s	5	5	020	020	CD
cord-030504-442pnl5s	5	6	-	-	HYPH
cord-030504-442pnl5s	5	7	00377	00377	CD
cord-030504-442pnl5s	5	8	-	-	SYM
cord-030504-442pnl5s	5	9	2	2	CD
cord-030504-442pnl5s	5	10	sha	sha	NN
cord-030504-442pnl5s	5	11	:	:	:
cord-030504-442pnl5s	5	12	e8d8af0fb94e7bb34eb2bbf7ab238ec39d779b04	e8d8af0fb94e7bb34eb2bbf7ab238ec39d779b04	NNP
cord-030504-442pnl5s	5	13	doc_id	doc_id	NNP
cord-030504-442pnl5s	5	14	:	:	:
cord-030504-442pnl5s	5	15	30504	30504	CD
cord-030504-442pnl5s	5	16	cord_uid	cord_uid	NN
cord-030504-442pnl5s	5	17	:	:	:
cord-030504-442pnl5s	5	18	442pnl5s	442pnl5s	CD
cord-030504-442pnl5s	6	1	BACKGROUND	background	NN
cord-030504-442pnl5s	6	2	:	:	:
cord-030504-442pnl5s	7	1	Enterovirus	enterovirus	NN
cord-030504-442pnl5s	7	2	71	71	CD
cord-030504-442pnl5s	8	1	(	(	-LRB-
cord-030504-442pnl5s	8	2	EV71	EV71	NNP
cord-030504-442pnl5s	8	3	)	)	-RRB-
cord-030504-442pnl5s	8	4	is	be	VBZ
cord-030504-442pnl5s	8	5	the	the	DT
cord-030504-442pnl5s	8	6	most	most	RBS
cord-030504-442pnl5s	8	7	commonly	commonly	RB
cord-030504-442pnl5s	8	8	implicated	implicate	VBN
cord-030504-442pnl5s	8	9	causative	causative	JJ
cord-030504-442pnl5s	8	10	agent	agent	NN
cord-030504-442pnl5s	8	11	of	of	IN
cord-030504-442pnl5s	8	12	severe	severe	JJ
cord-030504-442pnl5s	8	13	outbreaks	outbreak	NNS
cord-030504-442pnl5s	8	14	of	of	IN
cord-030504-442pnl5s	8	15	paediatric	paediatric	JJ
cord-030504-442pnl5s	8	16	hand	hand	NN
cord-030504-442pnl5s	8	17	,	,	,
cord-030504-442pnl5s	8	18	foot	foot	NN
cord-030504-442pnl5s	8	19	,	,	,
cord-030504-442pnl5s	8	20	and	and	CC
cord-030504-442pnl5s	8	21	mouth	mouth	NN
cord-030504-442pnl5s	8	22	disease	disease	NN
cord-030504-442pnl5s	8	23	(	(	-LRB-
cord-030504-442pnl5s	8	24	HFMD).VP1	hfmd).vp1	CD
cord-030504-442pnl5s	8	25	protein	protein	NN
cord-030504-442pnl5s	8	26	,	,	,
cord-030504-442pnl5s	8	27	a	a	DT
cord-030504-442pnl5s	8	28	capsid	capsid	JJ
cord-030504-442pnl5s	8	29	protein	protein	NN
cord-030504-442pnl5s	8	30	of	of	IN
cord-030504-442pnl5s	8	31	EV71	EV71	NNP
cord-030504-442pnl5s	8	32	,	,	,
cord-030504-442pnl5s	8	33	is	be	VBZ
cord-030504-442pnl5s	8	34	responsible	responsible	JJ
cord-030504-442pnl5s	8	35	for	for	IN
cord-030504-442pnl5s	8	36	the	the	DT
cord-030504-442pnl5s	8	37	genotype	genotype	NN
cord-030504-442pnl5s	8	38	of	of	IN
cord-030504-442pnl5s	8	39	the	the	DT
cord-030504-442pnl5s	8	40	virus	virus	NN
cord-030504-442pnl5s	8	41	and	and	CC
cord-030504-442pnl5s	8	42	is	be	VBZ
cord-030504-442pnl5s	8	43	essential	essential	JJ
cord-030504-442pnl5s	8	44	for	for	IN
cord-030504-442pnl5s	8	45	vaccine	vaccine	NN
cord-030504-442pnl5s	8	46	development	development	NN
cord-030504-442pnl5s	8	47	and	and	CC
cord-030504-442pnl5s	8	48	effectiveness	effectiveness	NN
cord-030504-442pnl5s	8	49	.	.	.
cord-030504-442pnl5s	9	1	However	however	RB
cord-030504-442pnl5s	9	2	,	,	,
cord-030504-442pnl5s	9	3	the	the	DT
cord-030504-442pnl5s	9	4	genotypes	genotype	NNS
cord-030504-442pnl5s	9	5	of	of	IN
cord-030504-442pnl5s	9	6	EV71	EV71	NNP
cord-030504-442pnl5s	9	7	isolates	isolate	NNS
cord-030504-442pnl5s	9	8	in	in	IN
cord-030504-442pnl5s	9	9	China	China	NNP
cord-030504-442pnl5s	9	10	are	be	VBP
cord-030504-442pnl5s	9	11	still	still	RB
cord-030504-442pnl5s	9	12	not	not	RB
cord-030504-442pnl5s	9	13	completely	completely	RB
cord-030504-442pnl5s	9	14	clear	clear	JJ
cord-030504-442pnl5s	9	15	.	.	.
cord-030504-442pnl5s	10	1	METHODS	methods	NN
cord-030504-442pnl5s	10	2	:	:	:
cord-030504-442pnl5s	11	1	The	the	DT
cord-030504-442pnl5s	11	2	VP1	vp1	NN
cord-030504-442pnl5s	11	3	gene	gene	NN
cord-030504-442pnl5s	11	4	sequences	sequence	NNS
cord-030504-442pnl5s	11	5	of	of	IN
cord-030504-442pnl5s	11	6	3712	3712	CD
cord-030504-442pnl5s	11	7	EV71	EV71	NNP
cord-030504-442pnl5s	11	8	virus	virus	NN
cord-030504-442pnl5s	11	9	strains	strain	VBZ
cord-030504-442pnl5s	11	10	from	from	IN
cord-030504-442pnl5s	11	11	China	China	NNP
cord-030504-442pnl5s	11	12	,	,	,
cord-030504-442pnl5s	11	13	excluding	exclude	VBG
cord-030504-442pnl5s	11	14	repetitive	repetitive	JJ
cord-030504-442pnl5s	11	15	sequences	sequence	NNS
cord-030504-442pnl5s	11	16	and	and	CC
cord-030504-442pnl5s	11	17	30	30	CD
cord-030504-442pnl5s	11	18	known	know	VBN
cord-030504-442pnl5s	11	19	EV71	EV71	NNP
cord-030504-442pnl5s	11	20	genotypes	genotype	NNS
cord-030504-442pnl5s	11	21	as	as	IN
cord-030504-442pnl5s	11	22	reference	reference	NN
cord-030504-442pnl5s	11	23	strains	strain	NNS
cord-030504-442pnl5s	11	24	,	,	,
cord-030504-442pnl5s	11	25	between	between	IN
cord-030504-442pnl5s	11	26	1986	1986	CD
cord-030504-442pnl5s	11	27	and	and	CC
cord-030504-442pnl5s	11	28	2019	2019	CD
cord-030504-442pnl5s	11	29	were	be	VBD
cord-030504-442pnl5s	11	30	obtained	obtain	VBN
cord-030504-442pnl5s	11	31	from	from	IN
cord-030504-442pnl5s	11	32	GenBank	GenBank	NNP
cord-030504-442pnl5s	11	33	.	.	.
cord-030504-442pnl5s	12	1	Phylogenetic	phylogenetic	JJ
cord-030504-442pnl5s	12	2	tree	tree	NN
cord-030504-442pnl5s	12	3	,	,	,
cord-030504-442pnl5s	12	4	amino	amino	NN
cord-030504-442pnl5s	12	5	acid	acid	NN
cord-030504-442pnl5s	12	6	homology	homology	NN
cord-030504-442pnl5s	12	7	,	,	,
cord-030504-442pnl5s	12	8	genetic	genetic	JJ
cord-030504-442pnl5s	12	9	variation	variation	NN
cord-030504-442pnl5s	12	10	and	and	CC
cord-030504-442pnl5s	12	11	genotype	genotype	NN
cord-030504-442pnl5s	12	12	analyses	analysis	NNS
cord-030504-442pnl5s	12	13	of	of	IN
cord-030504-442pnl5s	12	14	the	the	DT
cord-030504-442pnl5s	12	15	EV71VP1	EV71VP1	NNS
cord-030504-442pnl5s	12	16	protein	protein	NN
cord-030504-442pnl5s	12	17	were	be	VBD
cord-030504-442pnl5s	12	18	performed	perform	VBN
cord-030504-442pnl5s	12	19	with	with	IN
cord-030504-442pnl5s	12	20	MEGA	MEGA	NNP
cord-030504-442pnl5s	12	21	6.0	6.0	CD
cord-030504-442pnl5s	12	22	software	software	NN
cord-030504-442pnl5s	12	23	.	.	.
cord-030504-442pnl5s	13	1	RESULTS	result	NNS
cord-030504-442pnl5s	13	2	:	:	:
cord-030504-442pnl5s	14	1	The	the	DT
cord-030504-442pnl5s	14	2	amino	amino	NN
cord-030504-442pnl5s	14	3	acid	acid	NN
cord-030504-442pnl5s	14	4	identity	identity	NN
cord-030504-442pnl5s	14	5	was	be	VBD
cord-030504-442pnl5s	14	6	found	find	VBN
cord-030504-442pnl5s	14	7	to	to	TO
cord-030504-442pnl5s	14	8	be	be	VB
cord-030504-442pnl5s	14	9	88.33%–100	88.33%–100	CD
cord-030504-442pnl5s	14	10	%	%	NN
cord-030504-442pnl5s	14	11	among	among	IN
cord-030504-442pnl5s	14	12	the	the	DT
cord-030504-442pnl5s	14	13	3712	3712	CD
cord-030504-442pnl5s	14	14	EV71	EV71	NNP
cord-030504-442pnl5s	14	15	strains	strain	NNS
cord-030504-442pnl5s	14	16	,	,	,
cord-030504-442pnl5s	14	17	93.47%–100	93.47%–100	CD
cord-030504-442pnl5s	14	18	%	%	NN
cord-030504-442pnl5s	14	19	compared	compare	VBN
cord-030504-442pnl5s	14	20	with	with	IN
cord-030504-442pnl5s	14	21	vaccine	vaccine	NN
cord-030504-442pnl5s	14	22	strain	strain	NN
cord-030504-442pnl5s	14	23	H07	H07	NNP
cord-030504-442pnl5s	14	24	,	,	,
cord-030504-442pnl5s	14	25	and	and	CC
cord-030504-442pnl5s	14	26	93.04%–100	93.04%–100	CD
cord-030504-442pnl5s	14	27	%	%	NN
cord-030504-442pnl5s	14	28	compared	compare	VBN
cord-030504-442pnl5s	14	29	with	with	IN
cord-030504-442pnl5s	14	30	vaccine	vaccine	NN
cord-030504-442pnl5s	14	31	strains	strain	VBZ
cord-030504-442pnl5s	14	32	FY7VP5	FY7VP5	NNS
cord-030504-442pnl5s	14	33	or	or	CC
cord-030504-442pnl5s	14	34	FY-23	FY-23	NNP
cord-030504-442pnl5s	14	35	K	K	NNP
cord-030504-442pnl5s	14	36	-	-	HYPH
cord-030504-442pnl5s	14	37	B.	B.	NNP
cord-030504-442pnl5s	14	38	Since	since	IN
cord-030504-442pnl5s	14	39	2000	2000	CD
cord-030504-442pnl5s	15	1	,	,	,
cord-030504-442pnl5s	15	2	the	the	DT
cord-030504-442pnl5s	15	3	prevalent	prevalent	JJ
cord-030504-442pnl5s	15	4	strains	strain	NNS
cord-030504-442pnl5s	15	5	of	of	IN
cord-030504-442pnl5s	15	6	EV71	EV71	NNP
cord-030504-442pnl5s	15	7	were	be	VBD
cord-030504-442pnl5s	15	8	mainly	mainly	RB
cord-030504-442pnl5s	15	9	of	of	IN
cord-030504-442pnl5s	15	10	the	the	DT
cord-030504-442pnl5s	15	11	C4	C4	NNP
cord-030504-442pnl5s	15	12	genotype	genotype	NN
cord-030504-442pnl5s	15	13	.	.	.
cord-030504-442pnl5s	16	1	Among	among	IN
cord-030504-442pnl5s	16	2	these	these	DT
cord-030504-442pnl5s	16	3	,	,	,
cord-030504-442pnl5s	16	4	the	the	DT
cord-030504-442pnl5s	16	5	C4a	C4a	NNP
cord-030504-442pnl5s	16	6	subgenotype	subgenotype	NN
cord-030504-442pnl5s	16	7	was	be	VBD
cord-030504-442pnl5s	16	8	predominant	predominant	JJ
cord-030504-442pnl5s	16	9	,	,	,
cord-030504-442pnl5s	16	10	followed	follow	VBN
cord-030504-442pnl5s	16	11	by	by	IN
cord-030504-442pnl5s	16	12	the	the	DT
cord-030504-442pnl5s	16	13	C4b	c4b	NN
cord-030504-442pnl5s	16	14	subgenotype	subgenotype	NN
cord-030504-442pnl5s	16	15	;	;	:
cord-030504-442pnl5s	16	16	other	other	JJ
cord-030504-442pnl5s	16	17	subgenotypes	subgenotype	NNS
cord-030504-442pnl5s	16	18	appeared	appear	VBD
cord-030504-442pnl5s	16	19	sporadically	sporadically	RB
cord-030504-442pnl5s	16	20	between	between	IN
cord-030504-442pnl5s	16	21	2005	2005	CD
cord-030504-442pnl5s	16	22	and	and	CC
cord-030504-442pnl5s	16	23	2018	2018	CD
cord-030504-442pnl5s	16	24	in	in	IN
cord-030504-442pnl5s	16	25	mainland	mainland	NN
cord-030504-442pnl5s	16	26	China	China	NNP
cord-030504-442pnl5s	16	27	.	.	.
cord-030504-442pnl5s	17	1	The	the	DT
cord-030504-442pnl5s	17	2	B4	B4	NNP
cord-030504-442pnl5s	17	3	genotype	genotype	NN
cord-030504-442pnl5s	17	4	was	be	VBD
cord-030504-442pnl5s	17	5	the	the	DT
cord-030504-442pnl5s	17	6	main	main	JJ
cord-030504-442pnl5s	17	7	genotype	genotype	NN
cord-030504-442pnl5s	17	8	in	in	IN
cord-030504-442pnl5s	17	9	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	17	10	,	,	,
cord-030504-442pnl5s	17	11	and	and	CC
cord-030504-442pnl5s	17	12	the	the	DT
cord-030504-442pnl5s	17	13	epidemic	epidemic	NN
cord-030504-442pnl5s	17	14	strains	strain	NNS
cord-030504-442pnl5s	17	15	were	be	VBD
cord-030504-442pnl5s	17	16	constantly	constantly	RB
cord-030504-442pnl5s	17	17	changing	change	VBG
cord-030504-442pnl5s	17	18	.	.	.
cord-030504-442pnl5s	18	1	Some	some	DT
cord-030504-442pnl5s	18	2	amino	amino	NN
cord-030504-442pnl5s	18	3	acid	acid	NN
cord-030504-442pnl5s	18	4	variations	variation	NNS
cord-030504-442pnl5s	18	5	in	in	IN
cord-030504-442pnl5s	18	6	VP1	vp1	NN
cord-030504-442pnl5s	18	7	of	of	IN
cord-030504-442pnl5s	18	8	EV71	EV71	NNP
cord-030504-442pnl5s	18	9	occurred	occur	VBD
cord-030504-442pnl5s	18	10	with	with	IN
cord-030504-442pnl5s	18	11	high	high	JJ
cord-030504-442pnl5s	18	12	frequencies	frequency	NNS
cord-030504-442pnl5s	18	13	,	,	,
cord-030504-442pnl5s	18	14	including	include	VBG
cord-030504-442pnl5s	18	15	A289	A289	NNP
cord-030504-442pnl5s	18	16	T	T	NNP
cord-030504-442pnl5s	18	17	(	(	-LRB-
cord-030504-442pnl5s	18	18	20.99	20.99	CD
cord-030504-442pnl5s	18	19	%	%	NN
cord-030504-442pnl5s	18	20	)	)	-RRB-
cord-030504-442pnl5s	18	21	,	,	,
cord-030504-442pnl5s	18	22	H22Q	H22Q	NNP
cord-030504-442pnl5s	18	23	(	(	-LRB-
cord-030504-442pnl5s	18	24	16.49	16.49	CD
cord-030504-442pnl5s	18	25	%	%	NN
cord-030504-442pnl5s	18	26	)	)	-RRB-
cord-030504-442pnl5s	18	27	,	,	,
cord-030504-442pnl5s	18	28	A293S	A293S	NNP
cord-030504-442pnl5s	18	29	(	(	-LRB-
cord-030504-442pnl5s	18	30	15.95	15.95	CD
cord-030504-442pnl5s	18	31	%	%	NN
cord-030504-442pnl5s	18	32	)	)	-RRB-
cord-030504-442pnl5s	18	33	,	,	,
cord-030504-442pnl5s	18	34	S283	S283	NNP
cord-030504-442pnl5s	18	35	T	T	NNP
cord-030504-442pnl5s	18	36	(	(	-LRB-
cord-030504-442pnl5s	18	37	15.11	15.11	CD
cord-030504-442pnl5s	18	38	%	%	NN
cord-030504-442pnl5s	18	39	)	)	-RRB-
cord-030504-442pnl5s	18	40	,	,	,
cord-030504-442pnl5s	18	41	V249I	v249i	NN
cord-030504-442pnl5s	18	42	(	(	-LRB-
cord-030504-442pnl5s	18	43	7.76	7.76	CD
cord-030504-442pnl5s	18	44	%	%	NN
cord-030504-442pnl5s	18	45	)	)	-RRB-
cord-030504-442pnl5s	18	46	,	,	,
cord-030504-442pnl5s	18	47	N31D	n31d	NN
cord-030504-442pnl5s	18	48	(	(	-LRB-
cord-030504-442pnl5s	18	49	7.25	7.25	CD
cord-030504-442pnl5s	18	50	%	%	NN
cord-030504-442pnl5s	18	51	)	)	-RRB-
cord-030504-442pnl5s	18	52	,	,	,
cord-030504-442pnl5s	18	53	and	and	CC
cord-030504-442pnl5s	18	54	E98	E98	NNP
cord-030504-442pnl5s	18	55	K	K	NNP
cord-030504-442pnl5s	18	56	(	(	-LRB-
cord-030504-442pnl5s	18	57	6.65	6.65	CD
cord-030504-442pnl5s	18	58	%	%	NN
cord-030504-442pnl5s	18	59	)	)	-RRB-
cord-030504-442pnl5s	18	60	.	.	.
cord-030504-442pnl5s	19	1	CONCLUSION	conclusion	NN
cord-030504-442pnl5s	19	2	:	:	:
cord-030504-442pnl5s	20	1	The	the	DT
cord-030504-442pnl5s	20	2	C4	c4	NN
cord-030504-442pnl5s	20	3	genotype	genotype	NN
cord-030504-442pnl5s	20	4	of	of	IN
cord-030504-442pnl5s	20	5	EV71	EV71	NNP
cord-030504-442pnl5s	20	6	in	in	IN
cord-030504-442pnl5s	20	7	China	China	NNP
cord-030504-442pnl5s	20	8	matches	match	VBZ
cord-030504-442pnl5s	20	9	the	the	DT
cord-030504-442pnl5s	20	10	vaccine	vaccine	NN
cord-030504-442pnl5s	20	11	and	and	CC
cord-030504-442pnl5s	20	12	should	should	MD
cord-030504-442pnl5s	20	13	effectively	effectively	RB
cord-030504-442pnl5s	20	14	control	control	VB
cord-030504-442pnl5s	20	15	EV71	EV71	NNP
cord-030504-442pnl5s	20	16	.	.	.
cord-030504-442pnl5s	21	1	However	however	RB
cord-030504-442pnl5s	21	2	,	,	,
cord-030504-442pnl5s	21	3	the	the	DT
cord-030504-442pnl5s	21	4	efficacy	efficacy	NN
cord-030504-442pnl5s	21	5	of	of	IN
cord-030504-442pnl5s	21	6	the	the	DT
cord-030504-442pnl5s	21	7	vaccine	vaccine	NN
cord-030504-442pnl5s	21	8	is	be	VBZ
cord-030504-442pnl5s	21	9	partially	partially	RB
cord-030504-442pnl5s	21	10	affected	affect	VBN
cord-030504-442pnl5s	21	11	by	by	IN
cord-030504-442pnl5s	21	12	the	the	DT
cord-030504-442pnl5s	21	13	continuous	continuous	JJ
cord-030504-442pnl5s	21	14	change	change	NN
cord-030504-442pnl5s	21	15	in	in	IN
cord-030504-442pnl5s	21	16	epidemic	epidemic	NN
cord-030504-442pnl5s	21	17	strains	strain	NNS
cord-030504-442pnl5s	21	18	in	in	IN
cord-030504-442pnl5s	21	19	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	21	20	.	.	.
cord-030504-442pnl5s	22	1	These	these	DT
cord-030504-442pnl5s	22	2	results	result	NNS
cord-030504-442pnl5s	22	3	suggest	suggest	VBP
cord-030504-442pnl5s	22	4	that	that	IN
cord-030504-442pnl5s	22	5	the	the	DT
cord-030504-442pnl5s	22	6	genetic	genetic	JJ
cord-030504-442pnl5s	22	7	characteristics	characteristic	NNS
cord-030504-442pnl5s	22	8	of	of	IN
cord-030504-442pnl5s	22	9	the	the	DT
cord-030504-442pnl5s	22	10	EV71-VP1	ev71-vp1	NN
cord-030504-442pnl5s	22	11	region	region	NN
cord-030504-442pnl5s	22	12	should	should	MD
cord-030504-442pnl5s	22	13	be	be	VB
cord-030504-442pnl5s	22	14	continuously	continuously	RB
cord-030504-442pnl5s	22	15	monitored	monitor	VBN
cord-030504-442pnl5s	22	16	,	,	,
cord-030504-442pnl5s	22	17	which	which	WDT
cord-030504-442pnl5s	22	18	is	be	VBZ
cord-030504-442pnl5s	22	19	critical	critical	JJ
cord-030504-442pnl5s	22	20	for	for	IN
cord-030504-442pnl5s	22	21	epidemic	epidemic	NN
cord-030504-442pnl5s	22	22	control	control	NN
cord-030504-442pnl5s	22	23	and	and	CC
cord-030504-442pnl5s	22	24	vaccine	vaccine	NN
cord-030504-442pnl5s	22	25	design	design	NN
cord-030504-442pnl5s	22	26	to	to	TO
cord-030504-442pnl5s	22	27	prevent	prevent	VB
cord-030504-442pnl5s	22	28	EV71	EV71	NNP
cord-030504-442pnl5s	22	29	infection	infection	NN
cord-030504-442pnl5s	22	30	in	in	IN
cord-030504-442pnl5s	22	31	children	child	NNS
cord-030504-442pnl5s	22	32	.	.	.
cord-030504-442pnl5s	23	1	caused	cause	VBN
cord-030504-442pnl5s	23	2	by	by	IN
cord-030504-442pnl5s	23	3	EV71	EV71	NNP
cord-030504-442pnl5s	23	4	infection	infection	NN
cord-030504-442pnl5s	23	5	have	have	VBP
cord-030504-442pnl5s	23	6	been	be	VBN
cord-030504-442pnl5s	23	7	widely	widely	RB
cord-030504-442pnl5s	23	8	prevalent	prevalent	JJ
cord-030504-442pnl5s	23	9	in	in	IN
cord-030504-442pnl5s	23	10	China	China	NNP
cord-030504-442pnl5s	23	11	since	since	IN
cord-030504-442pnl5s	23	12	2007	2007	CD
cord-030504-442pnl5s	23	13	[	[	-LRB-
cord-030504-442pnl5s	23	14	13	13	CD
cord-030504-442pnl5s	23	15	]	]	-RRB-
cord-030504-442pnl5s	23	16	.	.	.
cord-030504-442pnl5s	24	1	For	for	IN
cord-030504-442pnl5s	24	2	example	example	NN
cord-030504-442pnl5s	24	3	,	,	,
cord-030504-442pnl5s	24	4	HFMD	HFMD	NNP
cord-030504-442pnl5s	24	5	pandemics	pandemic	NNS
cord-030504-442pnl5s	24	6	in	in	IN
cord-030504-442pnl5s	24	7	Linyi	Linyi	NNP
cord-030504-442pnl5s	24	8	city	city	NN
cord-030504-442pnl5s	24	9	,	,	,
cord-030504-442pnl5s	24	10	Shandong	Shandong	NNP
cord-030504-442pnl5s	24	11	Province	Province	NNP
cord-030504-442pnl5s	24	12	,	,	,
cord-030504-442pnl5s	24	13	and	and	CC
cord-030504-442pnl5s	24	14	Guangdong	Guangdong	NNP
cord-030504-442pnl5s	24	15	,	,	,
cord-030504-442pnl5s	24	16	Anhui	Anhui	NNP
cord-030504-442pnl5s	24	17	Province	Province	NNP
cord-030504-442pnl5s	24	18	,	,	,
cord-030504-442pnl5s	24	19	in	in	IN
cord-030504-442pnl5s	24	20	2008	2008	CD
cord-030504-442pnl5s	24	21	resulted	result	VBD
cord-030504-442pnl5s	24	22	in	in	IN
cord-030504-442pnl5s	24	23	tens	ten	NNS
cord-030504-442pnl5s	24	24	of	of	IN
cord-030504-442pnl5s	24	25	thousands	thousand	NNS
cord-030504-442pnl5s	24	26	of	of	IN
cord-030504-442pnl5s	24	27	childhood	childhood	NN
cord-030504-442pnl5s	24	28	infections	infection	NNS
cord-030504-442pnl5s	24	29	and	and	CC
cord-030504-442pnl5s	24	30	death	death	NN
cord-030504-442pnl5s	24	31	among	among	IN
cord-030504-442pnl5s	24	32	dozens	dozen	NNS
cord-030504-442pnl5s	24	33	of	of	IN
cord-030504-442pnl5s	24	34	children	child	NNS
cord-030504-442pnl5s	24	35	[	[	-LRB-
cord-030504-442pnl5s	24	36	14	14	CD
cord-030504-442pnl5s	24	37	,	,	,
cord-030504-442pnl5s	24	38	15	15	CD
cord-030504-442pnl5s	24	39	]	]	-RRB-
cord-030504-442pnl5s	24	40	.	.	.
cord-030504-442pnl5s	25	1	EV71	EV71	NNP
cord-030504-442pnl5s	25	2	belongs	belong	VBZ
cord-030504-442pnl5s	25	3	to	to	IN
cord-030504-442pnl5s	25	4	the	the	DT
cord-030504-442pnl5s	25	5	Enterovirus	Enterovirus	NNP
cord-030504-442pnl5s	25	6	genus	genus	NN
cord-030504-442pnl5s	25	7	of	of	IN
cord-030504-442pnl5s	25	8	the	the	DT
cord-030504-442pnl5s	25	9	RNA	RNA	NNP
cord-030504-442pnl5s	25	10	virus	virus	NN
cord-030504-442pnl5s	25	11	family	family	NN
cord-030504-442pnl5s	25	12	.	.	.
cord-030504-442pnl5s	26	1	EV71	EV71	NNP
cord-030504-442pnl5s	26	2	can	can	MD
cord-030504-442pnl5s	26	3	be	be	VB
cord-030504-442pnl5s	26	4	clustered	cluster	VBN
cord-030504-442pnl5s	26	5	into	into	IN
cord-030504-442pnl5s	26	6	three	three	CD
cord-030504-442pnl5s	26	7	genotypes	genotype	NNS
cord-030504-442pnl5s	26	8	according	accord	VBG
cord-030504-442pnl5s	26	9	to	to	IN
cord-030504-442pnl5s	26	10	nucleotide	nucleotide	JJ
cord-030504-442pnl5s	26	11	differences	difference	NNS
cord-030504-442pnl5s	26	12	in	in	IN
cord-030504-442pnl5s	26	13	the	the	DT
cord-030504-442pnl5s	26	14	VP1	VP1	NNP
cord-030504-442pnl5s	26	15	region	region	NN
cord-030504-442pnl5s	26	16	,	,	,
cord-030504-442pnl5s	26	17	including	include	VBG
cord-030504-442pnl5s	26	18	genotype	genotype	NN
cord-030504-442pnl5s	26	19	A	a	NN
cord-030504-442pnl5s	26	20	(	(	-LRB-
cord-030504-442pnl5s	26	21	BrCr	BrCr	NNP
cord-030504-442pnl5s	26	22	)	)	-RRB-
cord-030504-442pnl5s	26	23	with	with	IN
cord-030504-442pnl5s	26	24	only	only	RB
cord-030504-442pnl5s	26	25	one	one	CD
cord-030504-442pnl5s	26	26	member	member	NN
cord-030504-442pnl5s	26	27	,	,	,
cord-030504-442pnl5s	26	28	B	B	NNP
cord-030504-442pnl5s	26	29	and	and	CC
cord-030504-442pnl5s	26	30	C.	C.	NNP
cord-030504-442pnl5s	27	1	In	in	IN
cord-030504-442pnl5s	27	2	contrast	contrast	NN
cord-030504-442pnl5s	27	3	,	,	,
cord-030504-442pnl5s	27	4	genotypes	genotype	NNS
cord-030504-442pnl5s	27	5	B	b	NN
cord-030504-442pnl5s	27	6	and	and	CC
cord-030504-442pnl5s	27	7	C	C	NNP
cord-030504-442pnl5s	27	8	are	be	VBP
cord-030504-442pnl5s	27	9	divided	divide	VBN
cord-030504-442pnl5s	27	10	into	into	IN
cord-030504-442pnl5s	27	11	five	five	CD
cord-030504-442pnl5s	27	12	subgenotypes	subgenotype	NNS
cord-030504-442pnl5s	27	13	,	,	,
cord-030504-442pnl5s	27	14	B1-B5	B1-B5	NNP
cord-030504-442pnl5s	27	15	and	and	CC
cord-030504-442pnl5s	27	16	C1-C5	C1-C5	NNP
cord-030504-442pnl5s	27	17	,	,	,
cord-030504-442pnl5s	27	18	respectively	respectively	RB
cord-030504-442pnl5s	27	19	,	,	,
cord-030504-442pnl5s	27	20	and	and	CC
cord-030504-442pnl5s	27	21	genotype	genotype	NN
cord-030504-442pnl5s	27	22	C4	C4	NNP
cord-030504-442pnl5s	27	23	is	be	VBZ
cord-030504-442pnl5s	27	24	further	far	RBR
cord-030504-442pnl5s	27	25	subdivided	subdivide	VBN
cord-030504-442pnl5s	27	26	into	into	IN
cord-030504-442pnl5s	27	27	C4a	c4a	NN
cord-030504-442pnl5s	27	28	and	and	CC
cord-030504-442pnl5s	27	29	C4b	c4b	NN
cord-030504-442pnl5s	27	30	[	[	-LRB-
cord-030504-442pnl5s	27	31	16	16	CD
cord-030504-442pnl5s	27	32	]	]	-RRB-
cord-030504-442pnl5s	27	33	[	[	-LRB-
cord-030504-442pnl5s	27	34	17	17	CD
cord-030504-442pnl5s	27	35	]	]	-RRB-
cord-030504-442pnl5s	27	36	[	[	-LRB-
cord-030504-442pnl5s	27	37	18	18	CD
cord-030504-442pnl5s	27	38	]	]	-RRB-
cord-030504-442pnl5s	27	39	.	.	.
cord-030504-442pnl5s	28	1	In	in	IN
cord-030504-442pnl5s	28	2	China	China	NNP
cord-030504-442pnl5s	28	3	,	,	,
cord-030504-442pnl5s	28	4	genotypeC4	genotypeC4	NNP
cord-030504-442pnl5s	28	5	is	be	VBZ
cord-030504-442pnl5s	28	6	the	the	DT
cord-030504-442pnl5s	28	7	main	main	JJ
cord-030504-442pnl5s	28	8	epidemic	epidemic	NN
cord-030504-442pnl5s	28	9	strain	strain	NN
cord-030504-442pnl5s	28	10	;	;	:
cord-030504-442pnl5s	28	11	C4b	c4b	NN
cord-030504-442pnl5s	28	12	was	be	VBD
cord-030504-442pnl5s	28	13	the	the	DT
cord-030504-442pnl5s	28	14	predominant	predominant	JJ
cord-030504-442pnl5s	28	15	epidemic	epidemic	NN
cord-030504-442pnl5s	28	16	genotype	genotype	NN
cord-030504-442pnl5s	28	17	from	from	IN
cord-030504-442pnl5s	28	18	1998	1998	CD
cord-030504-442pnl5s	28	19	to	to	IN
cord-030504-442pnl5s	28	20	2004	2004	CD
cord-030504-442pnl5s	28	21	and	and	CC
cord-030504-442pnl5s	28	22	the	the	DT
cord-030504-442pnl5s	28	23	C4a	C4a	NNP
cord-030504-442pnl5s	28	24	subgenotype	subgenotype	NN
cord-030504-442pnl5s	28	25	after	after	IN
cord-030504-442pnl5s	28	26	2004	2004	CD
cord-030504-442pnl5s	28	27	in	in	IN
cord-030504-442pnl5s	28	28	mainland	mainland	NN
cord-030504-442pnl5s	28	29	China	China	NNP
cord-030504-442pnl5s	28	30	,	,	,
cord-030504-442pnl5s	28	31	though	though	IN
cord-030504-442pnl5s	28	32	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	28	33	strains	strain	NNS
cord-030504-442pnl5s	28	34	continue	continue	VBP
cord-030504-442pnl5s	28	35	to	to	TO
cord-030504-442pnl5s	28	36	circulate	circulate	VB
cord-030504-442pnl5s	28	37	,	,	,
cord-030504-442pnl5s	28	38	including	include	VBG
cord-030504-442pnl5s	28	39	C2	C2	NNP
cord-030504-442pnl5s	28	40	,	,	,
cord-030504-442pnl5s	28	41	B4	B4	NNP
cord-030504-442pnl5s	28	42	and	and	CC
cord-030504-442pnl5s	28	43	B5	b5	NN
cord-030504-442pnl5s	28	44	genotypes	genotype	NNS
cord-030504-442pnl5s	28	45	[	[	-LRB-
cord-030504-442pnl5s	28	46	19	19	CD
cord-030504-442pnl5s	28	47	]	]	-RRB-
cord-030504-442pnl5s	29	1	[	[	-LRB-
cord-030504-442pnl5s	29	2	20	20	CD
cord-030504-442pnl5s	29	3	]	]	-RRB-
cord-030504-442pnl5s	29	4	[	[	-LRB-
cord-030504-442pnl5s	29	5	21	21	CD
cord-030504-442pnl5s	29	6	]	]	-RRB-
cord-030504-442pnl5s	30	1	[	[	-LRB-
cord-030504-442pnl5s	30	2	22	22	CD
cord-030504-442pnl5s	30	3	]	]	-RRB-
cord-030504-442pnl5s	30	4	[	[	-LRB-
cord-030504-442pnl5s	30	5	23	23	CD
cord-030504-442pnl5s	30	6	]	]	-RRB-
cord-030504-442pnl5s	31	1	[	[	-LRB-
cord-030504-442pnl5s	31	2	24	24	CD
cord-030504-442pnl5s	31	3	]	]	-RRB-
cord-030504-442pnl5s	31	4	[	[	-LRB-
cord-030504-442pnl5s	31	5	25	25	CD
cord-030504-442pnl5s	31	6	]	]	-RRB-
cord-030504-442pnl5s	31	7	.	.	.
cord-030504-442pnl5s	32	1	Phase	phase	NN
cord-030504-442pnl5s	32	2	III	iii	CD
cord-030504-442pnl5s	32	3	clinical	clinical	JJ
cord-030504-442pnl5s	32	4	trials	trial	NNS
cord-030504-442pnl5s	32	5	of	of	IN
cord-030504-442pnl5s	32	6	vaccines	vaccine	NNS
cord-030504-442pnl5s	32	7	from	from	IN
cord-030504-442pnl5s	32	8	three	three	CD
cord-030504-442pnl5s	32	9	companies	company	NNS
cord-030504-442pnl5s	32	10	in	in	IN
cord-030504-442pnl5s	32	11	China	China	NNP
cord-030504-442pnl5s	32	12	have	have	VBP
cord-030504-442pnl5s	32	13	been	be	VBN
cord-030504-442pnl5s	32	14	completed	complete	VBN
cord-030504-442pnl5s	32	15	,	,	,
cord-030504-442pnl5s	32	16	and	and	CC
cord-030504-442pnl5s	32	17	the	the	DT
cord-030504-442pnl5s	32	18	genotypes	genotype	NNS
cord-030504-442pnl5s	32	19	of	of	IN
cord-030504-442pnl5s	32	20	their	-PRON-	PRP$
cord-030504-442pnl5s	32	21	vaccine	vaccine	NN
cord-030504-442pnl5s	32	22	strains	strain	NNS
cord-030504-442pnl5s	32	23	are	be	VBP
cord-030504-442pnl5s	32	24	all	all	DT
cord-030504-442pnl5s	32	25	C4a	c4a	NN
cord-030504-442pnl5s	32	26	subgenotypes	subgenotypes	NNPS
cord-030504-442pnl5s	32	27	[	[	-LRB-
cord-030504-442pnl5s	32	28	26	26	CD
cord-030504-442pnl5s	32	29	]	]	-RRB-
cord-030504-442pnl5s	32	30	.	.	.
cord-030504-442pnl5s	33	1	The	the	DT
cord-030504-442pnl5s	33	2	Vaccine	Vaccine	NNP
cord-030504-442pnl5s	33	3	Research	Research	NNP
cord-030504-442pnl5s	33	4	and	and	CC
cord-030504-442pnl5s	33	5	Development	Development	NNP
cord-030504-442pnl5s	33	6	Center	Center	NNP
cord-030504-442pnl5s	33	7	of	of	IN
cord-030504-442pnl5s	33	8	National	National	NNP
cord-030504-442pnl5s	33	9	Institutes	Institutes	NNPS
cord-030504-442pnl5s	33	10	of	of	IN
cord-030504-442pnl5s	33	11	Health	Health	NNP
cord-030504-442pnl5s	33	12	in	in	IN
cord-030504-442pnl5s	33	13	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	33	14	has	have	VBZ
cord-030504-442pnl5s	33	15	also	also	RB
cord-030504-442pnl5s	33	16	developed	develop	VBN
cord-030504-442pnl5s	33	17	an	an	DT
cord-030504-442pnl5s	33	18	FI	FI	NNP
cord-030504-442pnl5s	33	19	-	-	HYPH
cord-030504-442pnl5s	33	20	EV71	EV71	NNP
cord-030504-442pnl5s	33	21	vaccine	vaccine	NN
cord-030504-442pnl5s	33	22	based	base	VBN
cord-030504-442pnl5s	33	23	on	on	IN
cord-030504-442pnl5s	33	24	the	the	DT
cord-030504-442pnl5s	33	25	B4	B4	NNP
cord-030504-442pnl5s	33	26	subtype	subtype	NN
cord-030504-442pnl5s	33	27	(	(	-LRB-
cord-030504-442pnl5s	33	28	EV71vac	EV71vac	NNP
cord-030504-442pnl5s	33	29	)	)	-RRB-
cord-030504-442pnl5s	33	30	,	,	,
cord-030504-442pnl5s	33	31	which	which	WDT
cord-030504-442pnl5s	33	32	can	can	MD
cord-030504-442pnl5s	33	33	cause	cause	VB
cord-030504-442pnl5s	33	34	a	a	DT
cord-030504-442pnl5s	33	35	robust	robust	JJ
cord-030504-442pnl5s	33	36	cross	cross	NN
cord-030504-442pnl5s	33	37	-	-	JJ
cord-030504-442pnl5s	33	38	neutralizing	neutralize	VBG
cord-030504-442pnl5s	33	39	antibody	antibody	NN
cord-030504-442pnl5s	33	40	reaction	reaction	NN
cord-030504-442pnl5s	33	41	against	against	IN
cord-030504-442pnl5s	33	42	different	different	JJ
cord-030504-442pnl5s	33	43	EV71	EV71	NNP
cord-030504-442pnl5s	33	44	gene	gene	NN
cord-030504-442pnl5s	33	45	subtypes	subtype	NNS
cord-030504-442pnl5s	33	46	,	,	,
cord-030504-442pnl5s	33	47	such	such	JJ
cord-030504-442pnl5s	33	48	as	as	IN
cord-030504-442pnl5s	33	49	B4	B4	NNP
cord-030504-442pnl5s	33	50	,	,	,
cord-030504-442pnl5s	33	51	B1	b1	NN
cord-030504-442pnl5s	33	52	,	,	,
cord-030504-442pnl5s	33	53	B5	B5	NNP
cord-030504-442pnl5s	33	54	and	and	CC
cord-030504-442pnl5s	33	55	C4a	C4a	NNP
cord-030504-442pnl5s	33	56	[	[	-LRB-
cord-030504-442pnl5s	33	57	26	26	CD
cord-030504-442pnl5s	33	58	,	,	,
cord-030504-442pnl5s	33	59	27	27	CD
cord-030504-442pnl5s	33	60	]	]	-RRB-
cord-030504-442pnl5s	33	61	.	.	.
cord-030504-442pnl5s	34	1	Nonetheless	nonetheless	RB
cord-030504-442pnl5s	34	2	,	,	,
cord-030504-442pnl5s	34	3	there	there	EX
cord-030504-442pnl5s	34	4	are	be	VBP
cord-030504-442pnl5s	34	5	many	many	JJ
cord-030504-442pnl5s	34	6	reports	report	NNS
cord-030504-442pnl5s	34	7	on	on	IN
cord-030504-442pnl5s	34	8	recombination	recombination	NN
cord-030504-442pnl5s	34	9	between	between	IN
cord-030504-442pnl5s	34	10	different	different	JJ
cord-030504-442pnl5s	34	11	genotypes	genotype	NNS
cord-030504-442pnl5s	34	12	of	of	IN
cord-030504-442pnl5s	34	13	EV71	EV71	NNP
cord-030504-442pnl5s	34	14	[	[	-LRB-
cord-030504-442pnl5s	34	15	28	28	CD
cord-030504-442pnl5s	34	16	]	]	-RRB-
cord-030504-442pnl5s	34	17	[	[	-LRB-
cord-030504-442pnl5s	34	18	29	29	CD
cord-030504-442pnl5s	34	19	]	]	-RRB-
cord-030504-442pnl5s	34	20	[	[	-LRB-
cord-030504-442pnl5s	34	21	30	30	CD
cord-030504-442pnl5s	34	22	]	]	-RRB-
cord-030504-442pnl5s	34	23	[	[	-LRB-
cord-030504-442pnl5s	34	24	31	31	CD
cord-030504-442pnl5s	34	25	]	]	-RRB-
cord-030504-442pnl5s	34	26	,	,	,
cord-030504-442pnl5s	34	27	suggesting	suggest	VBG
cord-030504-442pnl5s	34	28	that	that	IN
cord-030504-442pnl5s	34	29	EV71	EV71	NNP
cord-030504-442pnl5s	34	30	has	have	VBZ
cord-030504-442pnl5s	34	31	high	high	JJ
cord-030504-442pnl5s	34	32	variability	variability	NN
cord-030504-442pnl5s	34	33	and	and	CC
cord-030504-442pnl5s	34	34	recombination	recombination	NN
cord-030504-442pnl5s	34	35	ability	ability	NN
cord-030504-442pnl5s	34	36	,	,	,
cord-030504-442pnl5s	34	37	which	which	WDT
cord-030504-442pnl5s	34	38	may	may	MD
cord-030504-442pnl5s	34	39	lead	lead	VB
cord-030504-442pnl5s	34	40	to	to	IN
cord-030504-442pnl5s	34	41	the	the	DT
cord-030504-442pnl5s	34	42	production	production	NN
cord-030504-442pnl5s	34	43	of	of	IN
cord-030504-442pnl5s	34	44	new	new	JJ
cord-030504-442pnl5s	34	45	pathogenic	pathogenic	JJ
cord-030504-442pnl5s	34	46	strains	strain	NNS
cord-030504-442pnl5s	34	47	.	.	.
cord-030504-442pnl5s	35	1	Therefore	therefore	RB
cord-030504-442pnl5s	35	2	,	,	,
cord-030504-442pnl5s	35	3	genome	genome	NN
cord-030504-442pnl5s	35	4	monitoring	monitoring	NN
cord-030504-442pnl5s	35	5	of	of	IN
cord-030504-442pnl5s	35	6	EV71	EV71	NNP
cord-030504-442pnl5s	35	7	epidemic	epidemic	NN
cord-030504-442pnl5s	35	8	strains	strain	NNS
cord-030504-442pnl5s	35	9	is	be	VBZ
cord-030504-442pnl5s	35	10	of	of	IN
cord-030504-442pnl5s	35	11	great	great	JJ
cord-030504-442pnl5s	35	12	significance	significance	NN
cord-030504-442pnl5s	35	13	for	for	IN
cord-030504-442pnl5s	35	14	the	the	DT
cord-030504-442pnl5s	35	15	prevention	prevention	NN
cord-030504-442pnl5s	35	16	and	and	CC
cord-030504-442pnl5s	35	17	control	control	NN
cord-030504-442pnl5s	35	18	of	of	IN
cord-030504-442pnl5s	35	19	EV71	EV71	NNP
cord-030504-442pnl5s	35	20	epidemics	epidemic	NNS
cord-030504-442pnl5s	35	21	and	and	CC
cord-030504-442pnl5s	35	22	can	can	MD
cord-030504-442pnl5s	35	23	guide	guide	VB
cord-030504-442pnl5s	35	24	the	the	DT
cord-030504-442pnl5s	35	25	application	application	NN
cord-030504-442pnl5s	35	26	of	of	IN
cord-030504-442pnl5s	35	27	the	the	DT
cord-030504-442pnl5s	35	28	EV71	EV71	NNP
cord-030504-442pnl5s	35	29	vaccine	vaccine	NN
cord-030504-442pnl5s	35	30	to	to	IN
cord-030504-442pnl5s	35	31	a	a	DT
cord-030504-442pnl5s	35	32	certain	certain	JJ
cord-030504-442pnl5s	35	33	extent	extent	NN
cord-030504-442pnl5s	35	34	.	.	.
cord-030504-442pnl5s	36	1	In	in	IN
cord-030504-442pnl5s	36	2	this	this	DT
cord-030504-442pnl5s	36	3	study	study	NN
cord-030504-442pnl5s	36	4	,	,	,
cord-030504-442pnl5s	36	5	the	the	DT
cord-030504-442pnl5s	36	6	VP1	vp1	NN
cord-030504-442pnl5s	36	7	sequences	sequence	NNS
cord-030504-442pnl5s	36	8	of	of	IN
cord-030504-442pnl5s	36	9	all	all	DT
cord-030504-442pnl5s	36	10	EV71	EV71	NNP
cord-030504-442pnl5s	36	11	viruses	virus	NNS
cord-030504-442pnl5s	36	12	registered	register	VBN
cord-030504-442pnl5s	36	13	in	in	IN
cord-030504-442pnl5s	36	14	Gen	Gen	NNP
cord-030504-442pnl5s	36	15	-	-	HYPH
cord-030504-442pnl5s	36	16	Bank	Bank	NNP
cord-030504-442pnl5s	36	17	in	in	IN
cord-030504-442pnl5s	36	18	China	China	NNP
cord-030504-442pnl5s	36	19	from	from	IN
cord-030504-442pnl5s	36	20	1996	1996	CD
cord-030504-442pnl5s	36	21	to	to	IN
cord-030504-442pnl5s	36	22	2019	2019	CD
cord-030504-442pnl5s	36	23	were	be	VBD
cord-030504-442pnl5s	36	24	collected	collect	VBN
cord-030504-442pnl5s	36	25	,	,	,
cord-030504-442pnl5s	36	26	and	and	CC
cord-030504-442pnl5s	36	27	the	the	DT
cord-030504-442pnl5s	36	28	molecular	molecular	JJ
cord-030504-442pnl5s	36	29	characteristics	characteristic	NNS
cord-030504-442pnl5s	36	30	of	of	IN
cord-030504-442pnl5s	36	31	genes	gene	NNS
cord-030504-442pnl5s	36	32	were	be	VBD
cord-030504-442pnl5s	36	33	analysed	analyse	VBN
cord-030504-442pnl5s	36	34	using	use	VBG
cord-030504-442pnl5s	36	35	bioinformatics	bioinformatics	NN
cord-030504-442pnl5s	36	36	software	software	NN
cord-030504-442pnl5s	36	37	to	to	TO
cord-030504-442pnl5s	36	38	provide	provide	VB
cord-030504-442pnl5s	36	39	a	a	DT
cord-030504-442pnl5s	36	40	scientific	scientific	JJ
cord-030504-442pnl5s	36	41	basis	basis	NN
cord-030504-442pnl5s	36	42	for	for	IN
cord-030504-442pnl5s	36	43	the	the	DT
cord-030504-442pnl5s	36	44	prevention	prevention	NN
cord-030504-442pnl5s	36	45	and	and	CC
cord-030504-442pnl5s	36	46	control	control	NN
cord-030504-442pnl5s	36	47	of	of	IN
cord-030504-442pnl5s	36	48	HFMD	HFMD	NNP
cord-030504-442pnl5s	36	49	epidemics	epidemic	NNS
cord-030504-442pnl5s	36	50	.	.	.
cord-030504-442pnl5s	37	1	(	(	-LRB-
cord-030504-442pnl5s	37	2	H07	H07	NNP
cord-030504-442pnl5s	37	3	,	,	,
cord-030504-442pnl5s	37	4	FY7VP5	FY7VP5	NNP
cord-030504-442pnl5s	37	5	,	,	,
cord-030504-442pnl5s	37	6	and	and	CC
cord-030504-442pnl5s	37	7	FY-23	FY-23	NNP
cord-030504-442pnl5s	37	8	K	K	NNP
cord-030504-442pnl5s	37	9	-	-	HYPH
cord-030504-442pnl5s	37	10	B	B	NNP
cord-030504-442pnl5s	37	11	)	)	-RRB-
cord-030504-442pnl5s	37	12	and	and	CC
cord-030504-442pnl5s	37	13	27	27	CD
cord-030504-442pnl5s	37	14	known	know	VBN
cord-030504-442pnl5s	37	15	genotypes	genotype	NNS
cord-030504-442pnl5s	37	16	of	of	IN
cord-030504-442pnl5s	37	17	EV71	EV71	NNP
cord-030504-442pnl5s	37	18	strains	strain	NNS
cord-030504-442pnl5s	37	19	were	be	VBD
cord-030504-442pnl5s	37	20	considered	consider	VBN
cord-030504-442pnl5s	37	21	reference	reference	NN
cord-030504-442pnl5s	37	22	sequences	sequence	NNS
cord-030504-442pnl5s	37	23	,	,	,
cord-030504-442pnl5s	37	24	as	as	IN
cord-030504-442pnl5s	37	25	presented	present	VBN
cord-030504-442pnl5s	37	26	in	in	IN
cord-030504-442pnl5s	37	27	Table	Table	NNP
cord-030504-442pnl5s	37	28	1	1	CD
cord-030504-442pnl5s	37	29	.	.	.
cord-030504-442pnl5s	38	1	The	the	DT
cord-030504-442pnl5s	38	2	complete	complete	JJ
cord-030504-442pnl5s	38	3	VP1	vp1	NN
cord-030504-442pnl5s	38	4	sequence	sequence	NN
cord-030504-442pnl5s	38	5	of	of	IN
cord-030504-442pnl5s	38	6	EV71	EV71	NNP
cord-030504-442pnl5s	38	7	strains	strain	NNS
cord-030504-442pnl5s	38	8	was	be	VBD
cord-030504-442pnl5s	38	9	compared	compare	VBN
cord-030504-442pnl5s	38	10	by	by	IN
cord-030504-442pnl5s	38	11	Molecular	Molecular	NNP
cord-030504-442pnl5s	38	12	Evolutionary	Evolutionary	NNP
cord-030504-442pnl5s	38	13	Genetics	Genetics	NNP
cord-030504-442pnl5s	38	14	Analysis	Analysis	NNP
cord-030504-442pnl5s	38	15	(	(	-LRB-
cord-030504-442pnl5s	38	16	MEGA	MEGA	NNP
cord-030504-442pnl5s	38	17	)	)	-RRB-
cord-030504-442pnl5s	38	18	version	version	NN
cord-030504-442pnl5s	38	19	6.0	6.0	CD
cord-030504-442pnl5s	38	20	[	[	-LRB-
cord-030504-442pnl5s	38	21	32	32	CD
cord-030504-442pnl5s	38	22	]	]	-RRB-
cord-030504-442pnl5s	38	23	.	.	.
cord-030504-442pnl5s	39	1	In	in	IN
cord-030504-442pnl5s	39	2	brief	brief	NN
cord-030504-442pnl5s	39	3	,	,	,
cord-030504-442pnl5s	39	4	a	a	DT
cord-030504-442pnl5s	39	5	phylogenetic	phylogenetic	JJ
cord-030504-442pnl5s	39	6	tree	tree	NN
cord-030504-442pnl5s	39	7	of	of	IN
cord-030504-442pnl5s	39	8	the	the	DT
cord-030504-442pnl5s	39	9	EV71VP1	ev71vp1	NN
cord-030504-442pnl5s	39	10	gene	gene	NN
cord-030504-442pnl5s	39	11	was	be	VBD
cord-030504-442pnl5s	39	12	constructed	construct	VBN
cord-030504-442pnl5s	39	13	by	by	IN
cord-030504-442pnl5s	39	14	the	the	DT
cord-030504-442pnl5s	39	15	adjacency	adjacency	NN
cord-030504-442pnl5s	39	16	method	method	NN
cord-030504-442pnl5s	39	17	(	(	-LRB-
cord-030504-442pnl5s	39	18	neighbour	neighbour	NN
cord-030504-442pnl5s	39	19	-	-	HYPH
cord-030504-442pnl5s	39	20	joining	joining	NN
cord-030504-442pnl5s	39	21	,	,	,
cord-030504-442pnl5s	39	22	N	N	NNP
cord-030504-442pnl5s	39	23	-	-	HYPH
cord-030504-442pnl5s	39	24	J	J	NNP
cord-030504-442pnl5s	39	25	)	)	-RRB-
cord-030504-442pnl5s	39	26	with	with	IN
cord-030504-442pnl5s	39	27	1000	1000	CD
cord-030504-442pnl5s	39	28	bootstrap	bootstrap	NN
cord-030504-442pnl5s	39	29	replications	replication	NNS
cord-030504-442pnl5s	39	30	.	.	.
cord-030504-442pnl5s	40	1	Homology	homology	NN
cord-030504-442pnl5s	40	2	and	and	CC
cord-030504-442pnl5s	40	3	variation	variation	NN
cord-030504-442pnl5s	40	4	of	of	IN
cord-030504-442pnl5s	40	5	EV71	EV71	NNP
cord-030504-442pnl5s	40	6	strain	strain	NN
cord-030504-442pnl5s	40	7	VP1	vp1	NN
cord-030504-442pnl5s	40	8	gene	gene	NN
cord-030504-442pnl5s	40	9	sequences	sequence	NNS
cord-030504-442pnl5s	40	10	were	be	VBD
cord-030504-442pnl5s	40	11	analysed	analyse	VBN
cord-030504-442pnl5s	40	12	by	by	IN
cord-030504-442pnl5s	40	13	MEGA	MEGA	NNP
cord-030504-442pnl5s	40	14	6.0	6.0	CD
cord-030504-442pnl5s	40	15	.	.	.
cord-030504-442pnl5s	41	1	A	a	DT
cord-030504-442pnl5s	41	2	phylogenetic	phylogenetic	JJ
cord-030504-442pnl5s	41	3	tree	tree	NN
cord-030504-442pnl5s	41	4	of	of	IN
cord-030504-442pnl5s	41	5	the	the	DT
cord-030504-442pnl5s	41	6	VP1	VP1	NNP
cord-030504-442pnl5s	41	7	amino	amino	NN
cord-030504-442pnl5s	41	8	acid	acid	NN
cord-030504-442pnl5s	41	9	sequence	sequence	NN
cord-030504-442pnl5s	41	10	was	be	VBD
cord-030504-442pnl5s	41	11	constructed	construct	VBN
cord-030504-442pnl5s	41	12	with	with	IN
cord-030504-442pnl5s	41	13	3712	3712	CD
cord-030504-442pnl5s	41	14	EV71	EV71	NNP
cord-030504-442pnl5s	41	15	isolates	isolate	NNS
cord-030504-442pnl5s	41	16	from	from	IN
cord-030504-442pnl5s	41	17	China	China	NNP
cord-030504-442pnl5s	41	18	and	and	CC
cord-030504-442pnl5s	41	19	30	30	CD
cord-030504-442pnl5s	41	20	reference	reference	NN
cord-030504-442pnl5s	41	21	strains	strain	NNS
cord-030504-442pnl5s	41	22	(	(	-LRB-
cord-030504-442pnl5s	41	23	Fig	Fig	NNP
cord-030504-442pnl5s	41	24	.	.	.
cord-030504-442pnl5s	41	25	3	3	CD
cord-030504-442pnl5s	41	26	)	)	-RRB-
cord-030504-442pnl5s	41	27	.	.	.
cord-030504-442pnl5s	42	1	Amino	amino	NN
cord-030504-442pnl5s	42	2	acid	acid	NN
cord-030504-442pnl5s	42	3	identity	identity	NN
cord-030504-442pnl5s	42	4	among	among	IN
cord-030504-442pnl5s	42	5	the	the	DT
cord-030504-442pnl5s	42	6	3712	3712	CD
cord-030504-442pnl5s	42	7	EV71	EV71	NNP
cord-030504-442pnl5s	42	8	strains	strain	NNS
cord-030504-442pnl5s	42	9	is	be	VBZ
cord-030504-442pnl5s	42	10	88.33%-100	88.33%-100	CD
cord-030504-442pnl5s	42	11	%	%	NN
cord-030504-442pnl5s	42	12	,	,	,
cord-030504-442pnl5s	42	13	93.47%-100	93.47%-100	CD
cord-030504-442pnl5s	42	14	%	%	NN
cord-030504-442pnl5s	42	15	compared	compare	VBN
cord-030504-442pnl5s	42	16	with	with	IN
cord-030504-442pnl5s	42	17	vaccine	vaccine	NN
cord-030504-442pnl5s	42	18	strain	strain	NN
cord-030504-442pnl5s	42	19	H07	H07	NNP
cord-030504-442pnl5s	42	20	and	and	CC
cord-030504-442pnl5s	42	21	93.04%-100	93.04%-100	CD
cord-030504-442pnl5s	42	22	%	%	NN
cord-030504-442pnl5s	42	23	compared	compare	VBN
cord-030504-442pnl5s	42	24	with	with	IN
cord-030504-442pnl5s	42	25	vaccine	vaccine	NN
cord-030504-442pnl5s	42	26	strains	strain	VBZ
cord-030504-442pnl5s	42	27	FY7VP5	FY7VP5	NNS
cord-030504-442pnl5s	42	28	or	or	CC
cord-030504-442pnl5s	42	29	FY-23	FY-23	NNP
cord-030504-442pnl5s	42	30	K	K	NNP
cord-030504-442pnl5s	42	31	-	-	HYPH
cord-030504-442pnl5s	42	32	B.	B.	NNP
cord-030504-442pnl5s	42	33	Among	among	IN
cord-030504-442pnl5s	42	34	the	the	DT
cord-030504-442pnl5s	42	35	EV71	EV71	NNP
cord-030504-442pnl5s	42	36	strains	strain	NNS
cord-030504-442pnl5s	42	37	,	,	,
cord-030504-442pnl5s	42	38	the	the	DT
cord-030504-442pnl5s	42	39	C4	C4	NNP
cord-030504-442pnl5s	42	40	genotype	genotype	NN
cord-030504-442pnl5s	42	41	accounted	account	VBD
cord-030504-442pnl5s	42	42	for	for	IN
cord-030504-442pnl5s	42	43	most	most	JJS
cord-030504-442pnl5s	42	44	of	of	IN
cord-030504-442pnl5s	42	45	the	the	DT
cord-030504-442pnl5s	42	46	EV71	EV71	NNP
cord-030504-442pnl5s	42	47	strains	strain	NNS
cord-030504-442pnl5s	42	48	,	,	,
cord-030504-442pnl5s	42	49	and	and	CC
cord-030504-442pnl5s	42	50	the	the	DT
cord-030504-442pnl5s	42	51	C4a	C4a	NNP
cord-030504-442pnl5s	42	52	subgenotype	subgenotype	NN
cord-030504-442pnl5s	42	53	was	be	VBD
cord-030504-442pnl5s	42	54	the	the	DT
cord-030504-442pnl5s	42	55	most	most	RBS
cord-030504-442pnl5s	42	56	common	common	JJ
cord-030504-442pnl5s	42	57	.	.	.
cord-030504-442pnl5s	43	1	Moreover	moreover	RB
cord-030504-442pnl5s	43	2	,	,	,
cord-030504-442pnl5s	43	3	B4	B4	NNP
cord-030504-442pnl5s	43	4	,	,	,
cord-030504-442pnl5s	43	5	C4b	C4b	NNP
cord-030504-442pnl5s	43	6	and	and	CC
cord-030504-442pnl5s	43	7	C2	C2	NNP
cord-030504-442pnl5s	43	8	were	be	VBD
cord-030504-442pnl5s	43	9	found	find	VBN
cord-030504-442pnl5s	43	10	to	to	TO
cord-030504-442pnl5s	43	11	be	be	VB
cord-030504-442pnl5s	43	12	important	important	JJ
cord-030504-442pnl5s	43	13	genotypes	genotype	NNS
cord-030504-442pnl5s	43	14	of	of	IN
cord-030504-442pnl5s	43	15	EV71	EV71	NNP
cord-030504-442pnl5s	43	16	;	;	:
cord-030504-442pnl5s	43	17	other	other	JJ
cord-030504-442pnl5s	43	18	subgenotypes	subgenotype	NNS
cord-030504-442pnl5s	43	19	appeared	appear	VBD
cord-030504-442pnl5s	43	20	sporadically	sporadically	RB
cord-030504-442pnl5s	43	21	.	.	.
cord-030504-442pnl5s	44	1	Among	among	IN
cord-030504-442pnl5s	44	2	the	the	DT
cord-030504-442pnl5s	44	3	3712	3712	CD
cord-030504-442pnl5s	44	4	strains	strain	NNS
cord-030504-442pnl5s	44	5	,	,	,
cord-030504-442pnl5s	44	6	the	the	DT
cord-030504-442pnl5s	44	7	first	first	JJ
cord-030504-442pnl5s	44	8	6	6	CD
cord-030504-442pnl5s	44	9	strains	strain	NNS
cord-030504-442pnl5s	44	10	isolated	isolate	VBN
cord-030504-442pnl5s	44	11	from	from	IN
cord-030504-442pnl5s	44	12	China	China	NNP
cord-030504-442pnl5s	44	13	in	in	IN
cord-030504-442pnl5s	44	14	1986were	1986were	CD
cord-030504-442pnl5s	44	15	all	all	DT
cord-030504-442pnl5s	44	16	of	of	IN
cord-030504-442pnl5s	44	17	the	the	DT
cord-030504-442pnl5s	44	18	B3	b3	NN
cord-030504-442pnl5s	44	19	genotype	genotype	NN
cord-030504-442pnl5s	44	20	,	,	,
cord-030504-442pnl5s	44	21	after	after	IN
cord-030504-442pnl5s	44	22	which	which	WDT
cord-030504-442pnl5s	44	23	different	different	JJ
cord-030504-442pnl5s	44	24	genotypes	genotype	NNS
cord-030504-442pnl5s	44	25	/	/	SYM
cord-030504-442pnl5s	44	26	subgenotypes	subgenotype	NNS
cord-030504-442pnl5s	44	27	were	be	VBD
cord-030504-442pnl5s	44	28	detected	detect	VBN
cord-030504-442pnl5s	44	29	in	in	IN
cord-030504-442pnl5s	44	30	China	China	NNP
cord-030504-442pnl5s	44	31	.	.	.
cord-030504-442pnl5s	45	1	From	from	IN
cord-030504-442pnl5s	45	2	1986	1986	CD
cord-030504-442pnl5s	45	3	to	to	IN
cord-030504-442pnl5s	45	4	2007	2007	CD
cord-030504-442pnl5s	45	5	,	,	,
cord-030504-442pnl5s	45	6	there	there	EX
cord-030504-442pnl5s	45	7	was	be	VBD
cord-030504-442pnl5s	45	8	a	a	DT
cord-030504-442pnl5s	45	9	small	small	JJ
cord-030504-442pnl5s	45	10	epidemic	epidemic	NN
cord-030504-442pnl5s	45	11	peak	peak	NN
cord-030504-442pnl5s	45	12	of	of	IN
cord-030504-442pnl5s	45	13	C2-genotype	C2-genotype	NNP
cord-030504-442pnl5s	45	14	EV71	EV71	NNP
cord-030504-442pnl5s	45	15	in	in	IN
cord-030504-442pnl5s	45	16	1998	1998	CD
cord-030504-442pnl5s	45	17	.	.	.
cord-030504-442pnl5s	46	1	Between	between	IN
cord-030504-442pnl5s	46	2	1999	1999	CD
cord-030504-442pnl5s	46	3	and	and	CC
cord-030504-442pnl5s	46	4	2003	2003	CD
cord-030504-442pnl5s	46	5	,	,	,
cord-030504-442pnl5s	46	6	the	the	DT
cord-030504-442pnl5s	46	7	B4	B4	NNP
cord-030504-442pnl5s	46	8	genotype	genotype	NN
cord-030504-442pnl5s	46	9	was	be	VBD
cord-030504-442pnl5s	46	10	the	the	DT
cord-030504-442pnl5s	46	11	predominant	predominant	JJ
cord-030504-442pnl5s	46	12	strain	strain	NN
cord-030504-442pnl5s	46	13	of	of	IN
cord-030504-442pnl5s	46	14	EV71	EV71	NNP
cord-030504-442pnl5s	46	15	.	.	.
cord-030504-442pnl5s	47	1	Most	Most	JJS
cord-030504-442pnl5s	47	2	EV71	EV71	NNP
cord-030504-442pnl5s	47	3	strains	strain	NNS
cord-030504-442pnl5s	47	4	between	between	IN
cord-030504-442pnl5s	47	5	2004	2004	CD
cord-030504-442pnl5s	47	6	and	and	CC
cord-030504-442pnl5s	47	7	2005	2005	CD
cord-030504-442pnl5s	47	8	were	be	VBD
cord-030504-442pnl5s	47	9	of	of	IN
cord-030504-442pnl5s	47	10	the	the	DT
cord-030504-442pnl5s	47	11	C3	C3	NNP
cord-030504-442pnl5s	47	12	genotype	genotype	NN
cord-030504-442pnl5s	47	13	,	,	,
cord-030504-442pnl5s	47	14	and	and	CC
cord-030504-442pnl5s	47	15	from	from	IN
cord-030504-442pnl5s	47	16	2006	2006	CD
cord-030504-442pnl5s	47	17	to	to	IN
cord-030504-442pnl5s	47	18	2018	2018	CD
cord-030504-442pnl5s	47	19	,	,	,
cord-030504-442pnl5s	47	20	the	the	DT
cord-030504-442pnl5s	47	21	C4a	C4a	NNP
cord-030504-442pnl5s	47	22	subgenotype	subgenotype	NN
cord-030504-442pnl5s	47	23	was	be	VBD
cord-030504-442pnl5s	47	24	the	the	DT
cord-030504-442pnl5s	47	25	most	most	RBS
cord-030504-442pnl5s	47	26	common	common	JJ
cord-030504-442pnl5s	47	27	epidemic	epidemic	NN
cord-030504-442pnl5s	47	28	strain	strain	NN
cord-030504-442pnl5s	47	29	.	.	.
cord-030504-442pnl5s	48	1	B4	B4	NNP
cord-030504-442pnl5s	48	2	and	and	CC
cord-030504-442pnl5s	48	3	C4b	c4b	NN
cord-030504-442pnl5s	48	4	genotypes	genotype	NNS
cord-030504-442pnl5s	48	5	also	also	RB
cord-030504-442pnl5s	48	6	accounted	account	VBD
cord-030504-442pnl5s	48	7	for	for	IN
cord-030504-442pnl5s	48	8	a	a	DT
cord-030504-442pnl5s	48	9	certain	certain	JJ
cord-030504-442pnl5s	48	10	proportion	proportion	NN
cord-030504-442pnl5s	48	11	(	(	-LRB-
cord-030504-442pnl5s	48	12	Table	table	NN
cord-030504-442pnl5s	48	13	2	2	CD
cord-030504-442pnl5s	48	14	and	and	CC
cord-030504-442pnl5s	48	15	Fig	Fig	NNP
cord-030504-442pnl5s	48	16	.	.	NNP
cord-030504-442pnl5s	48	17	4	4	CD
cord-030504-442pnl5s	48	18	)	)	-RRB-
cord-030504-442pnl5s	48	19	.	.	.
cord-030504-442pnl5s	49	1	Next	next	RB
cord-030504-442pnl5s	49	2	,	,	,
cord-030504-442pnl5s	49	3	the	the	DT
cord-030504-442pnl5s	49	4	EV71	EV71	NNP
cord-030504-442pnl5s	49	5	strains	strain	NNS
cord-030504-442pnl5s	49	6	isolated	isolate	VBN
cord-030504-442pnl5s	49	7	from	from	IN
cord-030504-442pnl5s	49	8	China	China	NNP
cord-030504-442pnl5s	49	9	,	,	,
cord-030504-442pnl5s	49	10	including	include	VBG
cord-030504-442pnl5s	49	11	mainland	mainland	NN
cord-030504-442pnl5s	49	12	China	China	NNP
cord-030504-442pnl5s	49	13	,	,	,
cord-030504-442pnl5s	49	14	Hong	Hong	NNP
cord-030504-442pnl5s	49	15	Kong	Kong	NNP
cord-030504-442pnl5s	49	16	,	,	,
cord-030504-442pnl5s	49	17	and	and	CC
cord-030504-442pnl5s	49	18	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	49	19	,	,	,
cord-030504-442pnl5s	49	20	were	be	VBD
cord-030504-442pnl5s	49	21	further	further	RB
cord-030504-442pnl5s	49	22	analysed	analyse	VBN
cord-030504-442pnl5s	49	23	to	to	TO
cord-030504-442pnl5s	49	24	explore	explore	VB
cord-030504-442pnl5s	49	25	their	-PRON-	PRP$
cord-030504-442pnl5s	49	26	genotypic	genotypic	JJ
cord-030504-442pnl5s	49	27	distribution	distribution	NN
cord-030504-442pnl5s	49	28	in	in	IN
cord-030504-442pnl5s	49	29	different	different	JJ
cord-030504-442pnl5s	49	30	years	year	NNS
cord-030504-442pnl5s	49	31	.	.	.
cord-030504-442pnl5s	50	1	The	the	DT
cord-030504-442pnl5s	50	2	results	result	NNS
cord-030504-442pnl5s	50	3	indicated	indicate	VBD
cord-030504-442pnl5s	50	4	that	that	IN
cord-030504-442pnl5s	50	5	from	from	IN
cord-030504-442pnl5s	50	6	2005	2005	CD
cord-030504-442pnl5s	50	7	to	to	IN
cord-030504-442pnl5s	50	8	2018	2018	CD
cord-030504-442pnl5s	50	9	,	,	,
cord-030504-442pnl5s	50	10	the	the	DT
cord-030504-442pnl5s	50	11	C4a	C4a	NNP
cord-030504-442pnl5s	50	12	subgenotype	subgenotype	NN
cord-030504-442pnl5s	50	13	was	be	VBD
cord-030504-442pnl5s	50	14	absolutely	absolutely	RB
cord-030504-442pnl5s	50	15	the	the	DT
cord-030504-442pnl5s	50	16	predominant	predominant	JJ
cord-030504-442pnl5s	50	17	strain	strain	NN
cord-030504-442pnl5s	50	18	of	of	IN
cord-030504-442pnl5s	50	19	EV71	EV71	NNP
cord-030504-442pnl5s	50	20	,	,	,
cord-030504-442pnl5s	50	21	followed	follow	VBN
cord-030504-442pnl5s	50	22	by	by	IN
cord-030504-442pnl5s	50	23	the	the	DT
cord-030504-442pnl5s	50	24	C4b	c4b	NN
cord-030504-442pnl5s	50	25	subgenotype	subgenotype	NN
cord-030504-442pnl5s	50	26	;	;	:
cord-030504-442pnl5s	50	27	other	other	JJ
cord-030504-442pnl5s	50	28	subgenotypes	subgenotype	NNS
cord-030504-442pnl5s	50	29	appeared	appear	VBD
cord-030504-442pnl5s	50	30	sporadically	sporadically	RB
cord-030504-442pnl5s	50	31	in	in	IN
cord-030504-442pnl5s	50	32	mainland	mainland	NN
cord-030504-442pnl5s	50	33	China	China	NNP
cord-030504-442pnl5s	50	34	.	.	.
cord-030504-442pnl5s	51	1	Moreover	moreover	RB
cord-030504-442pnl5s	51	2	,	,	,
cord-030504-442pnl5s	51	3	among	among	IN
cord-030504-442pnl5s	51	4	the	the	DT
cord-030504-442pnl5s	51	5	24	24	CD
cord-030504-442pnl5s	51	6	strains	strain	NNS
cord-030504-442pnl5s	51	7	isolated	isolate	VBN
cord-030504-442pnl5s	51	8	from	from	IN
cord-030504-442pnl5s	51	9	Hong	Hong	NNP
cord-030504-442pnl5s	51	10	Kong	Kong	NNP
cord-030504-442pnl5s	51	11	,	,	,
cord-030504-442pnl5s	51	12	there	there	EX
cord-030504-442pnl5s	51	13	were	be	VBD
cord-030504-442pnl5s	51	14	10	10	CD
cord-030504-442pnl5s	51	15	C4a	c4a	NN
cord-030504-442pnl5s	51	16	-	-	HYPH
cord-030504-442pnl5s	51	17	subgenotype	subgenotype	NN
cord-030504-442pnl5s	51	18	strains	strain	NNS
cord-030504-442pnl5s	51	19	Table	Table	NNP
cord-030504-442pnl5s	51	20	3	3	CD
cord-030504-442pnl5s	51	21	and	and	CC
cord-030504-442pnl5s	51	22	Fig	Fig	NNP
cord-030504-442pnl5s	51	23	.	.	.
cord-030504-442pnl5s	52	1	5	5	LS
cord-030504-442pnl5s	52	2	.	.	.
cord-030504-442pnl5s	53	1	However	however	RB
cord-030504-442pnl5s	53	2	,	,	,
cord-030504-442pnl5s	53	3	the	the	DT
cord-030504-442pnl5s	53	4	epidemic	epidemic	NN
cord-030504-442pnl5s	53	5	strains	strain	NNS
cord-030504-442pnl5s	53	6	of	of	IN
cord-030504-442pnl5s	53	7	EV71	EV71	NNP
cord-030504-442pnl5s	53	8	in	in	IN
cord-030504-442pnl5s	53	9	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	53	10	from	from	IN
cord-030504-442pnl5s	53	11	1986	1986	CD
cord-030504-442pnl5s	53	12	to	to	IN
cord-030504-442pnl5s	53	13	2018	2018	CD
cord-030504-442pnl5s	53	14	are	be	VBP
cord-030504-442pnl5s	53	15	quite	quite	RB
cord-030504-442pnl5s	53	16	different	different	JJ
cord-030504-442pnl5s	53	17	from	from	IN
cord-030504-442pnl5s	53	18	those	those	DT
cord-030504-442pnl5s	53	19	in	in	IN
cord-030504-442pnl5s	53	20	mainland	mainland	NN
cord-030504-442pnl5s	53	21	China	China	NNP
cord-030504-442pnl5s	53	22	.	.	.
cord-030504-442pnl5s	54	1	Overall	overall	RB
cord-030504-442pnl5s	54	2	,	,	,
cord-030504-442pnl5s	54	3	epidemic	epidemic	NN
cord-030504-442pnl5s	54	4	strains	strain	NNS
cord-030504-442pnl5s	54	5	are	be	VBP
cord-030504-442pnl5s	54	6	not	not	RB
cord-030504-442pnl5s	54	7	predominantly	predominantly	RB
cord-030504-442pnl5s	54	8	represented	represent	VBN
cord-030504-442pnl5s	54	9	by	by	IN
cord-030504-442pnl5s	54	10	a	a	DT
cord-030504-442pnl5s	54	11	single	single	JJ
cord-030504-442pnl5s	54	12	subgenotype	subgenotype	NN
cord-030504-442pnl5s	54	13	but	but	CC
cord-030504-442pnl5s	54	14	are	be	VBP
cord-030504-442pnl5s	54	15	constantly	constantly	RB
cord-030504-442pnl5s	54	16	changing	change	VBG
cord-030504-442pnl5s	54	17	.	.	.
cord-030504-442pnl5s	55	1	The	the	DT
cord-030504-442pnl5s	55	2	first	first	JJ
cord-030504-442pnl5s	55	3	6	6	CD
cord-030504-442pnl5s	55	4	strains	strain	NNS
cord-030504-442pnl5s	55	5	isolated	isolate	VBN
cord-030504-442pnl5s	55	6	in	in	IN
cord-030504-442pnl5s	55	7	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	55	8	in	in	IN
cord-030504-442pnl5s	55	9	1986	1986	CD
cord-030504-442pnl5s	55	10	were	be	VBD
cord-030504-442pnl5s	55	11	all	all	DT
cord-030504-442pnl5s	55	12	of	of	IN
cord-030504-442pnl5s	55	13	the	the	DT
cord-030504-442pnl5s	55	14	B3	B3	NNP
cord-030504-442pnl5s	55	15	genotype	genotype	NN
cord-030504-442pnl5s	55	16	.	.	.
cord-030504-442pnl5s	56	1	In	in	IN
cord-030504-442pnl5s	56	2	1998	1998	CD
cord-030504-442pnl5s	56	3	,	,	,
cord-030504-442pnl5s	56	4	C2	C2	NNP
cord-030504-442pnl5s	56	5	was	be	VBD
cord-030504-442pnl5s	56	6	the	the	DT
cord-030504-442pnl5s	56	7	predominant	predominant	JJ
cord-030504-442pnl5s	56	8	EV71	EV71	NNP
cord-030504-442pnl5s	56	9	genotype	genotype	NN
cord-030504-442pnl5s	56	10	in	in	IN
cord-030504-442pnl5s	56	11	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	56	12	.	.	.
cord-030504-442pnl5s	57	1	From	from	IN
cord-030504-442pnl5s	57	2	1999	1999	CD
cord-030504-442pnl5s	57	3	to	to	IN
cord-030504-442pnl5s	57	4	2003	2003	CD
cord-030504-442pnl5s	57	5	,	,	,
cord-030504-442pnl5s	57	6	2008	2008	CD
cord-030504-442pnl5s	57	7	to	to	IN
cord-030504-442pnl5s	57	8	2009	2009	CD
cord-030504-442pnl5s	57	9	,	,	,
cord-030504-442pnl5s	57	10	and	and	CC
cord-030504-442pnl5s	57	11	2011	2011	CD
cord-030504-442pnl5s	57	12	to	to	IN
cord-030504-442pnl5s	57	13	2012	2012	CD
cord-030504-442pnl5s	57	14	,	,	,
cord-030504-442pnl5s	57	15	the	the	DT
cord-030504-442pnl5s	57	16	epidemic	epidemic	NN
cord-030504-442pnl5s	57	17	strains	strain	NNS
cord-030504-442pnl5s	57	18	in	in	IN
cord-030504-442pnl5s	57	19	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	57	20	evolved	evolve	VBD
cord-030504-442pnl5s	57	21	mainly	mainly	RB
cord-030504-442pnl5s	57	22	into	into	IN
cord-030504-442pnl5s	57	23	B4-genotype	B4-genotype	NNP
cord-030504-442pnl5s	57	24	EV71	EV71	NNP
cord-030504-442pnl5s	57	25	strains	strain	NNS
cord-030504-442pnl5s	57	26	.	.	.
cord-030504-442pnl5s	58	1	Additionally	additionally	RB
cord-030504-442pnl5s	58	2	,	,	,
cord-030504-442pnl5s	58	3	C4a	C4a	NNP
cord-030504-442pnl5s	58	4	was	be	VBD
cord-030504-442pnl5s	58	5	an	an	DT
cord-030504-442pnl5s	58	6	important	important	JJ
cord-030504-442pnl5s	58	7	genotype	genotype	NN
cord-030504-442pnl5s	58	8	between	between	IN
cord-030504-442pnl5s	58	9	2010	2010	CD
cord-030504-442pnl5s	58	10	and	and	CC
cord-030504-442pnl5s	58	11	2011	2011	CD
cord-030504-442pnl5s	58	12	(	(	-LRB-
cord-030504-442pnl5s	58	13	Table	table	NN
cord-030504-442pnl5s	58	14	4	4	CD
cord-030504-442pnl5s	58	15	and	and	CC
cord-030504-442pnl5s	58	16	Fig	Fig	NNP
cord-030504-442pnl5s	58	17	.	.	NNP
cord-030504-442pnl5s	58	18	6	6	CD
cord-030504-442pnl5s	58	19	)	)	-RRB-
cord-030504-442pnl5s	58	20	.	.	.
cord-030504-442pnl5s	58	21	 	 	_SP
cord-030504-442pnl5s	59	1	Analysis	analysis	NN
cord-030504-442pnl5s	59	2	of	of	IN
cord-030504-442pnl5s	59	3	common	common	JJ
cord-030504-442pnl5s	59	4	amino	amino	NN
cord-030504-442pnl5s	59	5	acid	acid	NN
cord-030504-442pnl5s	59	6	variation	variation	NN
cord-030504-442pnl5s	59	7	sites	site	NNS
cord-030504-442pnl5s	59	8	in	in	IN
cord-030504-442pnl5s	59	9	the	the	DT
cord-030504-442pnl5s	59	10	EV71VP1	ev71vp1	NN
cord-030504-442pnl5s	59	11	region	region	NN
cord-030504-442pnl5s	59	12	showed	show	VBD
cord-030504-442pnl5s	59	13	that	that	IN
cord-030504-442pnl5s	59	14	of	of	IN
cord-030504-442pnl5s	59	15	the	the	DT
cord-030504-442pnl5s	59	16	3712	3712	CD
cord-030504-442pnl5s	59	17	strains	strain	NNS
cord-030504-442pnl5s	59	18	,	,	,
cord-030504-442pnl5s	59	19	residue	residue	NN
cord-030504-442pnl5s	59	20	289	289	CD
cord-030504-442pnl5s	59	21	was	be	VBD
cord-030504-442pnl5s	59	22	the	the	DT
cord-030504-442pnl5s	59	23	major	major	JJ
cord-030504-442pnl5s	59	24	common	common	JJ
cord-030504-442pnl5s	59	25	site	site	NN
cord-030504-442pnl5s	59	26	,	,	,
cord-030504-442pnl5s	59	27	with	with	IN
cord-030504-442pnl5s	59	28	a	a	DT
cord-030504-442pnl5s	59	29	total	total	JJ
cord-030504-442pnl5s	59	30	variation	variation	NN
cord-030504-442pnl5s	59	31	rate	rate	NN
cord-030504-442pnl5s	59	32	of	of	IN
cord-030504-442pnl5s	59	33	23.55	23.55	CD
cord-030504-442pnl5s	59	34	%	%	NN
cord-030504-442pnl5s	59	35	;	;	:
cord-030504-442pnl5s	59	36	A289	A289	NNP
cord-030504-442pnl5s	59	37	T	T	NNP
cord-030504-442pnl5s	59	38	was	be	VBD
cord-030504-442pnl5s	59	39	the	the	DT
cord-030504-442pnl5s	59	40	most	most	RBS
cord-030504-442pnl5s	59	41	common	common	JJ
cord-030504-442pnl5s	59	42	variant	variant	NN
cord-030504-442pnl5s	59	43	,	,	,
cord-030504-442pnl5s	59	44	accounting	account	VBG
cord-030504-442pnl5s	59	45	for	for	IN
cord-030504-442pnl5s	59	46	20.99	20.99	CD
cord-030504-442pnl5s	59	47	%	%	NN
cord-030504-442pnl5s	59	48	.	.	.
cord-030504-442pnl5s	60	1	Moreover	moreover	RB
cord-030504-442pnl5s	60	2	,	,	,
cord-030504-442pnl5s	60	3	10.24	10.24	CD
cord-030504-442pnl5s	60	4	%	%	NN
cord-030504-442pnl5s	60	5	of	of	IN
cord-030504-442pnl5s	60	6	strains	strain	NNS
cord-030504-442pnl5s	60	7	from	from	IN
cord-030504-442pnl5s	60	8	mainland	mainland	NN
cord-030504-442pnl5s	60	9	China	China	NNP
cord-030504-442pnl5s	60	10	,	,	,
cord-030504-442pnl5s	60	11	including	include	VBG
cord-030504-442pnl5s	60	12	Hong	Hong	NNP
cord-030504-442pnl5s	60	13	Kong	Kong	NNP
cord-030504-442pnl5s	60	14	,	,	,
cord-030504-442pnl5s	60	15	exhibited	exhibit	VBD
cord-030504-442pnl5s	60	16	this	this	DT
cord-030504-442pnl5s	60	17	variation	variation	NN
cord-030504-442pnl5s	60	18	;	;	:
cord-030504-442pnl5s	60	19	10.75	10.75	CD
cord-030504-442pnl5s	60	20	%	%	NN
cord-030504-442pnl5s	60	21	of	of	IN
cord-030504-442pnl5s	60	22	strains	strain	NNS
cord-030504-442pnl5s	60	23	from	from	IN
cord-030504-442pnl5s	60	24	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	60	25	also	also	RB
cord-030504-442pnl5s	60	26	exhibited	exhibit	VBD
cord-030504-442pnl5s	60	27	this	this	DT
cord-030504-442pnl5s	60	28	variation	variation	NN
cord-030504-442pnl5s	60	29	.	.	.
cord-030504-442pnl5s	61	1	There	there	EX
cord-030504-442pnl5s	61	2	was	be	VBD
cord-030504-442pnl5s	61	3	a	a	DT
cord-030504-442pnl5s	61	4	total	total	JJ
cord-030504-442pnl5s	61	5	mutation	mutation	NN
cord-030504-442pnl5s	61	6	rate	rate	NN
cord-030504-442pnl5s	61	7	of	of	IN
cord-030504-442pnl5s	61	8	21.85	21.85	CD
cord-030504-442pnl5s	61	9	%	%	NN
cord-030504-442pnl5s	61	10	at	at	IN
cord-030504-442pnl5s	61	11	amino	amino	NN
cord-030504-442pnl5s	61	12	acid	acid	NN
cord-030504-442pnl5s	61	13	position	position	NN
cord-030504-442pnl5s	61	14	22	22	CD
cord-030504-442pnl5s	61	15	in	in	IN
cord-030504-442pnl5s	61	16	the	the	DT
cord-030504-442pnl5s	61	17	VP1	VP1	NNP
cord-030504-442pnl5s	61	18	region	region	NN
cord-030504-442pnl5s	61	19	.	.	.
cord-030504-442pnl5s	62	1	The	the	DT
cord-030504-442pnl5s	62	2	frequency	frequency	NN
cord-030504-442pnl5s	62	3	of	of	IN
cord-030504-442pnl5s	62	4	the	the	DT
cord-030504-442pnl5s	62	5	H22Q	H22Q	NNP
cord-030504-442pnl5s	62	6	variation	variation	NN
cord-030504-442pnl5s	62	7	was	be	VBD
cord-030504-442pnl5s	62	8	detected	detect	VBN
cord-030504-442pnl5s	62	9	to	to	TO
cord-030504-442pnl5s	62	10	be	be	VB
cord-030504-442pnl5s	62	11	16.49	16.49	CD
cord-030504-442pnl5s	62	12	%	%	NN
cord-030504-442pnl5s	62	13	,	,	,
cord-030504-442pnl5s	62	14	of	of	IN
cord-030504-442pnl5s	62	15	which	which	WDT
cord-030504-442pnl5s	62	16	mainland	mainland	NN
cord-030504-442pnl5s	62	17	China	China	NNP
cord-030504-442pnl5s	62	18	,	,	,
cord-030504-442pnl5s	62	19	including	include	VBG
cord-030504-442pnl5s	62	20	Hong	Hong	NNP
cord-030504-442pnl5s	62	21	Kong	Kong	NNP
cord-030504-442pnl5s	62	22	,	,	,
cord-030504-442pnl5s	62	23	exhibited	exhibit	VBD
cord-030504-442pnl5s	62	24	5.50	5.50	CD
cord-030504-442pnl5s	62	25	%	%	NN
cord-030504-442pnl5s	62	26	;	;	:
cord-030504-442pnl5s	62	27	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	62	28	exhibited	exhibit	VBD
cord-030504-442pnl5s	62	29	10.99	10.99	CD
cord-030504-442pnl5s	62	30	%	%	NN
cord-030504-442pnl5s	62	31	.	.	.
cord-030504-442pnl5s	63	1	Furthermore	furthermore	RB
cord-030504-442pnl5s	63	2	,	,	,
cord-030504-442pnl5s	63	3	23	23	CD
cord-030504-442pnl5s	63	4	%	%	NN
cord-030504-442pnl5s	63	5	of	of	IN
cord-030504-442pnl5s	63	6	the	the	DT
cord-030504-442pnl5s	63	7	EV71	EV71	NNP
cord-030504-442pnl5s	63	8	strains	strain	NNS
cord-030504-442pnl5s	63	9	harboured	harbour	VBD
cord-030504-442pnl5s	63	10	an	an	DT
cord-030504-442pnl5s	63	11	H22R	H22R	NNP
cord-030504-442pnl5s	63	12	mutation	mutation	NN
cord-030504-442pnl5s	63	13	.	.	.
cord-030504-442pnl5s	64	1	The	the	DT
cord-030504-442pnl5s	64	2	mutation	mutation	NN
cord-030504-442pnl5s	64	3	rates	rate	NNS
cord-030504-442pnl5s	64	4	of	of	IN
cord-030504-442pnl5s	64	5	A293S	A293S	NNP
cord-030504-442pnl5s	64	6	,	,	,
cord-030504-442pnl5s	64	7	S283	S283	NNP
cord-030504-442pnl5s	64	8	T	T	NNP
cord-030504-442pnl5s	64	9	,	,	,
cord-030504-442pnl5s	64	10	V249I	v249i	NN
cord-030504-442pnl5s	64	11	,	,	,
cord-030504-442pnl5s	64	12	N31D	n31d	NN
cord-030504-442pnl5s	64	13	and	and	CC
cord-030504-442pnl5s	64	14	E98	E98	NNP
cord-030504-442pnl5s	64	15	K	K	NNP
cord-030504-442pnl5s	64	16	were	be	VBD
cord-030504-442pnl5s	64	17	15.95	15.95	CD
cord-030504-442pnl5s	64	18	%	%	NN
cord-030504-442pnl5s	64	19	,	,	,
cord-030504-442pnl5s	64	20	15.11	15.11	CD
cord-030504-442pnl5s	64	21	%	%	NN
cord-030504-442pnl5s	64	22	,	,	,
cord-030504-442pnl5s	64	23	7.76	7.76	CD
cord-030504-442pnl5s	64	24	%	%	NN
cord-030504-442pnl5s	64	25	,	,	,
cord-030504-442pnl5s	64	26	7.76	7.76	CD
cord-030504-442pnl5s	64	27	%	%	NN
cord-030504-442pnl5s	64	28	and	and	CC
cord-030504-442pnl5s	64	29	6.65	6.65	CD
cord-030504-442pnl5s	64	30	%	%	NN
cord-030504-442pnl5s	64	31	,	,	,
cord-030504-442pnl5s	64	32	respectively	respectively	RB
cord-030504-442pnl5s	64	33	.	.	.
cord-030504-442pnl5s	65	1	Among	among	IN
cord-030504-442pnl5s	65	2	the	the	DT
cord-030504-442pnl5s	65	3	common	common	JJ
cord-030504-442pnl5s	65	4	sites	site	NNS
cord-030504-442pnl5s	65	5	of	of	IN
cord-030504-442pnl5s	65	6	amino	amino	NN
cord-030504-442pnl5s	65	7	acid	acid	NN
cord-030504-442pnl5s	65	8	variation	variation	NN
cord-030504-442pnl5s	65	9	in	in	IN
cord-030504-442pnl5s	65	10	the	the	DT
cord-030504-442pnl5s	65	11	EV71VP1	ev71vp1	NN
cord-030504-442pnl5s	65	12	region	region	NN
cord-030504-442pnl5s	65	13	,	,	,
cord-030504-442pnl5s	65	14	the	the	DT
cord-030504-442pnl5s	65	15	most	most	RBS
cord-030504-442pnl5s	65	16	common	common	JJ
cord-030504-442pnl5s	65	17	was	be	VBD
cord-030504-442pnl5s	65	18	residue	residue	NN
cord-030504-442pnl5s	65	19	293	293	CD
cord-030504-442pnl5s	65	20	,	,	,
cord-030504-442pnl5s	65	21	with	with	IN
cord-030504-442pnl5s	65	22	five	five	CD
cord-030504-442pnl5s	65	23	types	type	NNS
cord-030504-442pnl5s	65	24	of	of	IN
cord-030504-442pnl5s	65	25	amino	amino	NN
cord-030504-442pnl5s	65	26	acid	acid	NN
cord-030504-442pnl5s	65	27	variation	variation	NN
cord-030504-442pnl5s	65	28	,	,	,
cord-030504-442pnl5s	65	29	among	among	IN
cord-030504-442pnl5s	65	30	which	which	WDT
cord-030504-442pnl5s	65	31	the	the	DT
cord-030504-442pnl5s	65	32	A293S	A293S	NNP
cord-030504-442pnl5s	65	33	mutation	mutation	NN
cord-030504-442pnl5s	65	34	was	be	VBD
cord-030504-442pnl5s	65	35	the	the	DT
cord-030504-442pnl5s	65	36	most	most	RBS
cord-030504-442pnl5s	65	37	common	common	JJ
cord-030504-442pnl5s	65	38	(	(	-LRB-
cord-030504-442pnl5s	65	39	Table	table	NN
cord-030504-442pnl5s	65	40	5	5	CD
cord-030504-442pnl5s	65	41	)	)	-RRB-
cord-030504-442pnl5s	65	42	.	.	.
cord-030504-442pnl5s	66	1	It	-PRON-	PRP
cord-030504-442pnl5s	66	2	has	have	VBZ
cord-030504-442pnl5s	66	3	been	be	VBN
cord-030504-442pnl5s	66	4	reported	report	VBN
cord-030504-442pnl5s	66	5	that	that	IN
cord-030504-442pnl5s	66	6	since	since	IN
cord-030504-442pnl5s	66	7	2004	2004	CD
cord-030504-442pnl5s	66	8	,	,	,
cord-030504-442pnl5s	66	9	the	the	DT
cord-030504-442pnl5s	66	10	major	major	JJ
cord-030504-442pnl5s	66	11	EV71	EV71	NNP
cord-030504-442pnl5s	66	12	strains	strain	NNS
cord-030504-442pnl5s	66	13	in	in	IN
cord-030504-442pnl5s	66	14	mainland	mainland	NN
cord-030504-442pnl5s	66	15	China	China	NNP
cord-030504-442pnl5s	66	16	basically	basically	RB
cord-030504-442pnl5s	66	17	belong	belong	VBP
cord-030504-442pnl5s	66	18	to	to	IN
cord-030504-442pnl5s	66	19	the	the	DT
cord-030504-442pnl5s	66	20	C4	C4	NNP
cord-030504-442pnl5s	66	21	genotype	genotype	NN
cord-030504-442pnl5s	66	22	[	[	-LRB-
cord-030504-442pnl5s	66	23	18	18	CD
cord-030504-442pnl5s	66	24	,	,	,
cord-030504-442pnl5s	66	25	33	33	CD
cord-030504-442pnl5s	66	26	]	]	-RRB-
cord-030504-442pnl5s	66	27	.	.	.
cord-030504-442pnl5s	67	1	The	the	DT
cord-030504-442pnl5s	67	2	immune	immune	JJ
cord-030504-442pnl5s	67	3	effectiveness	effectiveness	NN
cord-030504-442pnl5s	67	4	of	of	IN
cord-030504-442pnl5s	67	5	inactivated	inactivate	VBN
cord-030504-442pnl5s	67	6	vaccines	vaccine	NNS
cord-030504-442pnl5s	67	7	mostly	mostly	RB
cord-030504-442pnl5s	67	8	depends	depend	VBZ
cord-030504-442pnl5s	67	9	on	on	IN
cord-030504-442pnl5s	67	10	the	the	DT
cord-030504-442pnl5s	67	11	antigenic	antigenic	JJ
cord-030504-442pnl5s	67	12	correlation	correlation	NN
cord-030504-442pnl5s	67	13	between	between	IN
cord-030504-442pnl5s	67	14	epidemic	epidemic	NN
cord-030504-442pnl5s	67	15	strains	strain	NNS
cord-030504-442pnl5s	67	16	and	and	CC
cord-030504-442pnl5s	67	17	vaccine	vaccine	NN
cord-030504-442pnl5s	67	18	strains	strain	NNS
cord-030504-442pnl5s	67	19	,	,	,
cord-030504-442pnl5s	67	20	which	which	WDT
cord-030504-442pnl5s	67	21	are	be	VBP
cord-030504-442pnl5s	67	22	often	often	RB
cord-030504-442pnl5s	67	23	best	well	RBS
cord-030504-442pnl5s	67	24	for	for	IN
cord-030504-442pnl5s	67	25	preventing	prevent	VBG
cord-030504-442pnl5s	67	26	infection	infection	NN
cord-030504-442pnl5s	67	27	of	of	IN
cord-030504-442pnl5s	67	28	the	the	DT
cord-030504-442pnl5s	67	29	same	same	JJ
cord-030504-442pnl5s	67	30	subtype	subtype	NN
cord-030504-442pnl5s	67	31	virus	virus	NN
cord-030504-442pnl5s	67	32	but	but	CC
cord-030504-442pnl5s	67	33	are	be	VBP
cord-030504-442pnl5s	67	34	inferior	inferior	JJ
cord-030504-442pnl5s	67	35	against	against	IN
cord-030504-442pnl5s	67	36	different	different	JJ
cord-030504-442pnl5s	67	37	subtypes	subtype	NNS
cord-030504-442pnl5s	67	38	[	[	-LRB-
cord-030504-442pnl5s	67	39	30	30	CD
cord-030504-442pnl5s	67	40	]	]	-RRB-
cord-030504-442pnl5s	67	41	.	.	.
cord-030504-442pnl5s	68	1	Recent	recent	JJ
cord-030504-442pnl5s	68	2	studies	study	NNS
cord-030504-442pnl5s	68	3	have	have	VBP
cord-030504-442pnl5s	68	4	also	also	RB
cord-030504-442pnl5s	68	5	shown	show	VBN
cord-030504-442pnl5s	68	6	that	that	IN
cord-030504-442pnl5s	68	7	the	the	DT
cord-030504-442pnl5s	68	8	EV71	EV71	NNP
cord-030504-442pnl5s	68	9	vaccine	vaccine	NN
cord-030504-442pnl5s	68	10	(	(	-LRB-
cord-030504-442pnl5s	68	11	especially	especially	RB
cord-030504-442pnl5s	68	12	in	in	IN
cord-030504-442pnl5s	68	13	children	child	NNS
cord-030504-442pnl5s	68	14	who	who	WP
cord-030504-442pnl5s	68	15	receive	receive	VBP
cord-030504-442pnl5s	68	16	2	2	CD
cord-030504-442pnl5s	68	17	doses	dose	NNS
cord-030504-442pnl5s	68	18	)	)	-RRB-
cord-030504-442pnl5s	68	19	can	can	MD
cord-030504-442pnl5s	68	20	effectively	effectively	RB
cord-030504-442pnl5s	68	21	prevent	prevent	VB
cord-030504-442pnl5s	68	22	and	and	CC
cord-030504-442pnl5s	68	23	control	control	VB
cord-030504-442pnl5s	68	24	childhood	childhood	NN
cord-030504-442pnl5s	68	25	EV71-associated	EV71-associated	NNP
cord-030504-442pnl5s	68	26	HFMD	HFMD	NNP
cord-030504-442pnl5s	68	27	but	but	CC
cord-030504-442pnl5s	68	28	has	have	VBZ
cord-030504-442pnl5s	68	29	no	no	DT
cord-030504-442pnl5s	68	30	protective	protective	JJ
cord-030504-442pnl5s	68	31	effect	effect	NN
cord-030504-442pnl5s	68	32	against	against	IN
cord-030504-442pnl5s	68	33	coxsackievirus	coxsackievirus	NNP
cord-030504-442pnl5s	68	34	(	(	-LRB-
cord-030504-442pnl5s	68	35	CV	CV	NNP
cord-030504-442pnl5s	68	36	)	)	-RRB-
cord-030504-442pnl5s	68	37	A6	A6	NNP
cord-030504-442pnl5s	68	38	(	(	-LRB-
cord-030504-442pnl5s	68	39	CVA-6	CVA-6	NNP
cord-030504-442pnl5s	68	40	)	)	-RRB-
cord-030504-442pnl5s	68	41	or	or	CC
cord-030504-442pnl5s	68	42	CVA16	CVA16	NNP
cord-030504-442pnl5s	68	43	,	,	,
cord-030504-442pnl5s	68	44	and	and	CC
cord-030504-442pnl5s	68	45	there	there	EX
cord-030504-442pnl5s	68	46	is	be	VBZ
cord-030504-442pnl5s	68	47	no	no	DT
cord-030504-442pnl5s	68	48	explanation	explanation	NN
cord-030504-442pnl5s	68	49	for	for	IN
cord-030504-442pnl5s	68	50	the	the	DT
cord-030504-442pnl5s	68	51	effectiveness	effectiveness	NN
cord-030504-442pnl5s	68	52	of	of	IN
cord-030504-442pnl5s	68	53	other	other	JJ
cord-030504-442pnl5s	68	54	subtypes	subtype	NNS
cord-030504-442pnl5s	68	55	of	of	IN
cord-030504-442pnl5s	68	56	EV71	EV71	NNP
cord-030504-442pnl5s	68	57	(	(	-LRB-
cord-030504-442pnl5s	68	58	excluding	exclude	VBG
cord-030504-442pnl5s	68	59	C4a	c4a	CD
cord-030504-442pnl5s	68	60	subtypes	subtype	NNS
cord-030504-442pnl5s	68	61	)	)	-RRB-
cord-030504-442pnl5s	68	62	[	[	-LRB-
cord-030504-442pnl5s	68	63	34	34	CD
cord-030504-442pnl5s	68	64	]	]	-RRB-
cord-030504-442pnl5s	68	65	.	.	.
cord-030504-442pnl5s	69	1	These	these	DT
cord-030504-442pnl5s	69	2	studies	study	NNS
cord-030504-442pnl5s	69	3	show	show	VBP
cord-030504-442pnl5s	69	4	that	that	IN
cord-030504-442pnl5s	69	5	vaccine	vaccine	NN
cord-030504-442pnl5s	69	6	research	research	NN
cord-030504-442pnl5s	69	7	and	and	CC
cord-030504-442pnl5s	69	8	development	development	NN
cord-030504-442pnl5s	69	9	for	for	IN
cord-030504-442pnl5s	69	10	EV71	EV71	NNP
cord-030504-442pnl5s	69	11	combined	combine	VBN
cord-030504-442pnl5s	69	12	with	with	IN
cord-030504-442pnl5s	69	13	CVA6	CVA6	NNP
cord-030504-442pnl5s	69	14	and	and	CC
cord-030504-442pnl5s	69	15	CVA16	CVA16	NNP
cord-030504-442pnl5s	69	16	and	and	CC
cord-030504-442pnl5s	69	17	other	other	JJ
cord-030504-442pnl5s	69	18	multivalent	multivalent	JJ
cord-030504-442pnl5s	69	19	vaccines	vaccine	NNS
cord-030504-442pnl5s	69	20	might	may	MD
cord-030504-442pnl5s	69	21	better	better	RB
cord-030504-442pnl5s	69	22	prevent	prevent	VB
cord-030504-442pnl5s	69	23	EV71	EV71	NNP
cord-030504-442pnl5s	69	24	infection	infection	NN
cord-030504-442pnl5s	69	25	.	.	.
cord-030504-442pnl5s	70	1	Interestingly	interestingly	RB
cord-030504-442pnl5s	70	2	,	,	,
cord-030504-442pnl5s	70	3	this	this	DT
cord-030504-442pnl5s	70	4	study	study	NN
cord-030504-442pnl5s	70	5	found	find	VBD
cord-030504-442pnl5s	70	6	that	that	IN
cord-030504-442pnl5s	70	7	the	the	DT
cord-030504-442pnl5s	70	8	EV71	EV71	NNP
cord-030504-442pnl5s	70	9	epidemic	epidemic	NN
cord-030504-442pnl5s	70	10	strains	strain	NNS
cord-030504-442pnl5s	70	11	in	in	IN
cord-030504-442pnl5s	70	12	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	70	13	were	be	VBD
cord-030504-442pnl5s	70	14	mainly	mainly	RB
cord-030504-442pnl5s	70	15	of	of	IN
cord-030504-442pnl5s	70	16	the	the	DT
cord-030504-442pnl5s	70	17	B4	B4	NNP
cord-030504-442pnl5s	70	18	genotype	genotype	NN
cord-030504-442pnl5s	70	19	,	,	,
cord-030504-442pnl5s	70	20	which	which	WDT
cord-030504-442pnl5s	70	21	was	be	VBD
cord-030504-442pnl5s	70	22	different	different	JJ
cord-030504-442pnl5s	70	23	from	from	IN
cord-030504-442pnl5s	70	24	those	those	DT
cord-030504-442pnl5s	70	25	in	in	IN
cord-030504-442pnl5s	70	26	mainland	mainland	NN
cord-030504-442pnl5s	70	27	China	China	NNP
cord-030504-442pnl5s	70	28	;	;	:
cord-030504-442pnl5s	70	29	EV71	EV71	NNP
cord-030504-442pnl5s	70	30	epidemic	epidemic	NN
cord-030504-442pnl5s	70	31	strains	strain	NNS
cord-030504-442pnl5s	70	32	are	be	VBP
cord-030504-442pnl5s	70	33	also	also	RB
cord-030504-442pnl5s	70	34	constantly	constantly	RB
cord-030504-442pnl5s	70	35	changing	change	VBG
cord-030504-442pnl5s	70	36	,	,	,
cord-030504-442pnl5s	70	37	which	which	WDT
cord-030504-442pnl5s	70	38	is	be	VBZ
cord-030504-442pnl5s	70	39	consistent	consistent	JJ
cord-030504-442pnl5s	70	40	with	with	IN
cord-030504-442pnl5s	70	41	a	a	DT
cord-030504-442pnl5s	70	42	previous	previous	JJ
cord-030504-442pnl5s	70	43	report	report	NN
cord-030504-442pnl5s	70	44	[	[	-LRB-
cord-030504-442pnl5s	70	45	26	26	CD
cord-030504-442pnl5s	70	46	]	]	-RRB-
cord-030504-442pnl5s	70	47	.	.	.
cord-030504-442pnl5s	71	1	According	accord	VBG
cord-030504-442pnl5s	71	2	to	to	IN
cord-030504-442pnl5s	71	3	a	a	DT
cord-030504-442pnl5s	71	4	human	human	JJ
cord-030504-442pnl5s	71	5	phase	phase	NN
cord-030504-442pnl5s	71	6	1	1	CD
cord-030504-442pnl5s	71	7	clinical	clinical	JJ
cord-030504-442pnl5s	71	8	trial	trial	NN
cord-030504-442pnl5s	71	9	on	on	IN
cord-030504-442pnl5s	71	10	adults	adult	NNS
cord-030504-442pnl5s	71	11	in	in	IN
cord-030504-442pnl5s	71	12	2010	2010	CD
cord-030504-442pnl5s	71	13	,	,	,
cord-030504-442pnl5s	71	14	the	the	DT
cord-030504-442pnl5s	71	15	FI	FI	NNP
cord-030504-442pnl5s	71	16	-	-	HYPH
cord-030504-442pnl5s	71	17	EV71	EV71	NNP
cord-030504-442pnl5s	71	18	vaccine	vaccine	NN
cord-030504-442pnl5s	71	19	(	(	-LRB-
cord-030504-442pnl5s	71	20	EV71vac	EV71vac	NNP
cord-030504-442pnl5s	71	21	)	)	-RRB-
cord-030504-442pnl5s	71	22	based	base	VBN
cord-030504-442pnl5s	71	23	on	on	IN
cord-030504-442pnl5s	71	24	the	the	DT
cord-030504-442pnl5s	71	25	B4	B4	NNP
cord-030504-442pnl5s	71	26	genotype	genotype	NN
cord-030504-442pnl5s	71	27	from	from	IN
cord-030504-442pnl5s	71	28	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	71	29	is	be	VBZ
cord-030504-442pnl5s	71	30	safe	safe	JJ
cord-030504-442pnl5s	71	31	and	and	CC
cord-030504-442pnl5s	71	32	induces	induce	VBZ
cord-030504-442pnl5s	71	33	a	a	DT
cord-030504-442pnl5s	71	34	high	high	JJ
cord-030504-442pnl5s	71	35	titre	titre	NN
cord-030504-442pnl5s	71	36	of	of	IN
cord-030504-442pnl5s	71	37	neutralizing	neutralize	VBG
cord-030504-442pnl5s	71	38	antibodies	antibody	NNS
cord-030504-442pnl5s	71	39	against	against	IN
cord-030504-442pnl5s	71	40	EV71	EV71	NNP
cord-030504-442pnl5s	71	41	;	;	:
cord-030504-442pnl5s	71	42	it	-PRON-	PRP
cord-030504-442pnl5s	71	43	was	be	VBD
cord-030504-442pnl5s	71	44	also	also	RB
cord-030504-442pnl5s	71	45	highly	highly	RB
cord-030504-442pnl5s	71	46	effective	effective	JJ
cord-030504-442pnl5s	71	47	against	against	IN
cord-030504-442pnl5s	71	48	B1	b1	NN
cord-030504-442pnl5s	71	49	,	,	,
cord-030504-442pnl5s	71	50	B5	B5	NNP
cord-030504-442pnl5s	71	51	,	,	,
cord-030504-442pnl5s	71	52	and	and	CC
cord-030504-442pnl5s	71	53	C4a	c4a	NN
cord-030504-442pnl5s	71	54	strains	strain	NNS
cord-030504-442pnl5s	71	55	.	.	.
cord-030504-442pnl5s	72	1	However	however	RB
cord-030504-442pnl5s	72	2	,	,	,
cord-030504-442pnl5s	72	3	the	the	DT
cord-030504-442pnl5s	72	4	titres	titre	NNS
cord-030504-442pnl5s	72	5	of	of	IN
cord-030504-442pnl5s	72	6	neutralizing	neutralize	VBG
cord-030504-442pnl5s	72	7	antibodies	antibody	NNS
cord-030504-442pnl5s	72	8	against	against	IN
cord-030504-442pnl5s	72	9	C4b	c4b	NN
cord-030504-442pnl5s	72	10	and	and	CC
cord-030504-442pnl5s	72	11	CVA16	CVA16	NNP
cord-030504-442pnl5s	72	12	were	be	VBD
cord-030504-442pnl5s	72	13	low	low	JJ
cord-030504-442pnl5s	72	14	in	in	IN
cord-030504-442pnl5s	72	15	20	20	CD
cord-030504-442pnl5s	72	16	%	%	NN
cord-030504-442pnl5s	72	17	of	of	IN
cord-030504-442pnl5s	72	18	volunteers	volunteer	NNS
cord-030504-442pnl5s	72	19	,	,	,
cord-030504-442pnl5s	72	20	and	and	CC
cord-030504-442pnl5s	72	21	virus	virus	NN
cord-030504-442pnl5s	72	22	-	-	HYPH
cord-030504-442pnl5s	72	23	neutralizing	neutralize	VBG
cord-030504-442pnl5s	72	24	antibodies	antibody	NNS
cord-030504-442pnl5s	72	25	against	against	IN
cord-030504-442pnl5s	72	26	the	the	DT
cord-030504-442pnl5s	72	27	C2	C2	NNP
cord-030504-442pnl5s	72	28	genotype	genotype	NN
cord-030504-442pnl5s	72	29	were	be	VBD
cord-030504-442pnl5s	72	30	not	not	RB
cord-030504-442pnl5s	72	31	detected	detect	VBN
cord-030504-442pnl5s	72	32	in	in	IN
cord-030504-442pnl5s	72	33	90	90	CD
cord-030504-442pnl5s	72	34	%	%	NN
cord-030504-442pnl5s	72	35	of	of	IN
cord-030504-442pnl5s	72	36	vaccine	vaccine	NN
cord-030504-442pnl5s	72	37	recipients	recipient	NNS
cord-030504-442pnl5s	72	38	[	[	-LRB-
cord-030504-442pnl5s	72	39	26	26	CD
cord-030504-442pnl5s	72	40	,	,	,
cord-030504-442pnl5s	72	41	27	27	CD
cord-030504-442pnl5s	72	42	]	]	-RRB-
cord-030504-442pnl5s	72	43	.	.	.
cord-030504-442pnl5s	73	1	These	these	DT
cord-030504-442pnl5s	73	2	studies	study	NNS
cord-030504-442pnl5s	73	3	indicate	indicate	VBP
cord-030504-442pnl5s	73	4	that	that	IN
cord-030504-442pnl5s	73	5	it	-PRON-	PRP
cord-030504-442pnl5s	73	6	is	be	VBZ
cord-030504-442pnl5s	73	7	necessary	necessary	JJ
cord-030504-442pnl5s	73	8	to	to	IN
cord-030504-442pnl5s	73	9	H	h	NN
cord-030504-442pnl5s	73	10	,	,	,
cord-030504-442pnl5s	73	11	histidine	histidine	NN
cord-030504-442pnl5s	73	12	;	;	:
cord-030504-442pnl5s	73	13	Q	q	NN
cord-030504-442pnl5s	73	14	,	,	,
cord-030504-442pnl5s	73	15	glutamine	glutamine	NN
cord-030504-442pnl5s	73	16	;	;	:
cord-030504-442pnl5s	73	17	R	r	NN
cord-030504-442pnl5s	73	18	,	,	,
cord-030504-442pnl5s	73	19	arginine	arginine	NN
cord-030504-442pnl5s	73	20	;	;	:
cord-030504-442pnl5s	73	21	N	n	CD
cord-030504-442pnl5s	73	22	,	,	,
cord-030504-442pnl5s	73	23	asparagine	asparagine	NN
cord-030504-442pnl5s	73	24	;	;	:
cord-030504-442pnl5s	73	25	D	d	JJ
cord-030504-442pnl5s	73	26	,	,	,
cord-030504-442pnl5s	73	27	aspartic	aspartic	JJ
cord-030504-442pnl5s	73	28	acid	acid	NN
cord-030504-442pnl5s	73	29	;	;	:
cord-030504-442pnl5s	73	30	S	s	NN
cord-030504-442pnl5s	73	31	,	,	,
cord-030504-442pnl5s	73	32	serine	serine	NN
cord-030504-442pnl5s	73	33	;	;	:
cord-030504-442pnl5s	73	34	G	g	NN
cord-030504-442pnl5s	73	35	,	,	,
cord-030504-442pnl5s	73	36	glycine	glycine	NN
cord-030504-442pnl5s	73	37	;	;	:
cord-030504-442pnl5s	73	38	E	e	NN
cord-030504-442pnl5s	73	39	,	,	,
cord-030504-442pnl5s	73	40	glutamic	glutamic	JJ
cord-030504-442pnl5s	73	41	acid	acid	NN
cord-030504-442pnl5s	73	42	;	;	:
cord-030504-442pnl5s	73	43	K	k	NN
cord-030504-442pnl5s	73	44	,	,	,
cord-030504-442pnl5s	73	45	lysine	lysine	NN
cord-030504-442pnl5s	73	46	;	;	:
cord-030504-442pnl5s	73	47	A	a	DT
cord-030504-442pnl5s	73	48	,	,	,
cord-030504-442pnl5s	73	49	alanine	alanine	NN
cord-030504-442pnl5s	73	50	;	;	:
cord-030504-442pnl5s	73	51	L	l	NN
cord-030504-442pnl5s	73	52	,	,	,
cord-030504-442pnl5s	73	53	leucine	leucine	NN
cord-030504-442pnl5s	73	54	;	;	:
cord-030504-442pnl5s	73	55	V	v	NN
cord-030504-442pnl5s	73	56	,	,	,
cord-030504-442pnl5s	73	57	valine	valine	NN
cord-030504-442pnl5s	73	58	;	;	:
cord-030504-442pnl5s	73	59	I	-PRON-	PRP
cord-030504-442pnl5s	73	60	,	,	,
cord-030504-442pnl5s	73	61	isoleucine	isoleucine	NNP
cord-030504-442pnl5s	73	62	;	;	:
cord-030504-442pnl5s	73	63	F	F	NNP
cord-030504-442pnl5s	73	64	,	,	,
cord-030504-442pnl5s	73	65	phenylalanine	phenylalanine	NN
cord-030504-442pnl5s	73	66	;	;	:
cord-030504-442pnl5s	73	67	T	t	NN
cord-030504-442pnl5s	73	68	,	,	,
cord-030504-442pnl5s	73	69	threonine	threonine	NN
cord-030504-442pnl5s	73	70	;	;	:
cord-030504-442pnl5s	73	71	P	p	NN
cord-030504-442pnl5s	73	72	,	,	,
cord-030504-442pnl5s	74	1	proline	proline	NNP
cord-030504-442pnl5s	74	2	strengthen	strengthen	VB
cord-030504-442pnl5s	74	3	the	the	DT
cord-030504-442pnl5s	74	4	monitoring	monitoring	NN
cord-030504-442pnl5s	74	5	of	of	IN
cord-030504-442pnl5s	74	6	EV71	EV71	NNP
cord-030504-442pnl5s	74	7	genotypes	genotype	NNS
cord-030504-442pnl5s	74	8	;	;	:
cord-030504-442pnl5s	74	9	new	new	JJ
cord-030504-442pnl5s	74	10	multivalent	multivalent	JJ
cord-030504-442pnl5s	74	11	and	and	CC
cord-030504-442pnl5s	74	12	effective	effective	JJ
cord-030504-442pnl5s	74	13	vaccines	vaccine	NNS
cord-030504-442pnl5s	74	14	that	that	WDT
cord-030504-442pnl5s	74	15	can	can	MD
cord-030504-442pnl5s	74	16	cover	cover	VB
cord-030504-442pnl5s	74	17	local	local	JJ
cord-030504-442pnl5s	74	18	strains	strain	NNS
cord-030504-442pnl5s	74	19	should	should	MD
cord-030504-442pnl5s	74	20	be	be	VB
cord-030504-442pnl5s	74	21	designed	design	VBN
cord-030504-442pnl5s	74	22	and	and	CC
cord-030504-442pnl5s	74	23	applied	apply	VBN
cord-030504-442pnl5s	74	24	according	accord	VBG
cord-030504-442pnl5s	74	25	to	to	IN
cord-030504-442pnl5s	74	26	the	the	DT
cord-030504-442pnl5s	74	27	genotypes	genotype	NNS
cord-030504-442pnl5s	74	28	of	of	IN
cord-030504-442pnl5s	74	29	the	the	DT
cord-030504-442pnl5s	74	30	local	local	JJ
cord-030504-442pnl5s	74	31	predominant	predominant	JJ
cord-030504-442pnl5s	74	32	EV71	EV71	NNP
cord-030504-442pnl5s	74	33	epidemic	epidemic	NN
cord-030504-442pnl5s	74	34	strains	strain	NNS
cord-030504-442pnl5s	74	35	to	to	TO
cord-030504-442pnl5s	74	36	ensure	ensure	VB
cord-030504-442pnl5s	74	37	that	that	IN
cord-030504-442pnl5s	74	38	the	the	DT
cord-030504-442pnl5s	74	39	vaccine	vaccine	NN
cord-030504-442pnl5s	74	40	is	be	VBZ
cord-030504-442pnl5s	74	41	more	more	RBR
cord-030504-442pnl5s	74	42	accurate	accurate	JJ
cord-030504-442pnl5s	74	43	in	in	IN
cord-030504-442pnl5s	74	44	controlling	control	VBG
cord-030504-442pnl5s	74	45	HFMD	HFMD	NNP
cord-030504-442pnl5s	74	46	epidemics	epidemic	NNS
cord-030504-442pnl5s	74	47	.	.	.
cord-030504-442pnl5s	75	1	Some	some	DT
cord-030504-442pnl5s	75	2	studies	study	NNS
cord-030504-442pnl5s	75	3	have	have	VBP
cord-030504-442pnl5s	75	4	shown	show	VBN
cord-030504-442pnl5s	75	5	that	that	IN
cord-030504-442pnl5s	75	6	the	the	DT
cord-030504-442pnl5s	75	7	H22Q	H22Q	NNP
cord-030504-442pnl5s	75	8	mutation	mutation	NN
cord-030504-442pnl5s	75	9	in	in	IN
cord-030504-442pnl5s	75	10	the	the	DT
cord-030504-442pnl5s	75	11	VP1	VP1	NNP
cord-030504-442pnl5s	75	12	protein	protein	NN
cord-030504-442pnl5s	75	13	of	of	IN
cord-030504-442pnl5s	75	14	EV71	EV71	NNP
cord-030504-442pnl5s	75	15	can	can	MD
cord-030504-442pnl5s	75	16	lead	lead	VB
cord-030504-442pnl5s	75	17	to	to	IN
cord-030504-442pnl5s	75	18	a	a	DT
cord-030504-442pnl5s	75	19	decrease	decrease	NN
cord-030504-442pnl5s	75	20	in	in	IN
cord-030504-442pnl5s	75	21	the	the	DT
cord-030504-442pnl5s	75	22	adsorption	adsorption	NN
cord-030504-442pnl5s	75	23	capacity	capacity	NN
cord-030504-442pnl5s	75	24	of	of	IN
cord-030504-442pnl5s	75	25	the	the	DT
cord-030504-442pnl5s	75	26	C4	C4	NNP
cord-030504-442pnl5s	75	27	genotype	genotype	NN
cord-030504-442pnl5s	75	28	to	to	TO
cord-030504-442pnl5s	75	29	host	host	NN
cord-030504-442pnl5s	75	30	cells	cell	NNS
cord-030504-442pnl5s	75	31	[	[	-LRB-
cord-030504-442pnl5s	75	32	35	35	CD
cord-030504-442pnl5s	75	33	]	]	-RRB-
cord-030504-442pnl5s	75	34	[	[	-LRB-
cord-030504-442pnl5s	75	35	36	36	CD
cord-030504-442pnl5s	75	36	]	]	-RRB-
cord-030504-442pnl5s	75	37	[	[	-LRB-
cord-030504-442pnl5s	75	38	37	37	CD
cord-030504-442pnl5s	75	39	]	]	-RRB-
cord-030504-442pnl5s	75	40	.	.	.
cord-030504-442pnl5s	76	1	The	the	DT
cord-030504-442pnl5s	76	2	amino	amino	NN
cord-030504-442pnl5s	76	3	acid	acid	NN
cord-030504-442pnl5s	76	4	at	at	IN
cord-030504-442pnl5s	76	5	position	position	NN
cord-030504-442pnl5s	76	6	22	22	CD
cord-030504-442pnl5s	76	7	of	of	IN
cord-030504-442pnl5s	76	8	78.15	78.15	CD
cord-030504-442pnl5s	76	9	%	%	NN
cord-030504-442pnl5s	76	10	of	of	IN
cord-030504-442pnl5s	76	11	the	the	DT
cord-030504-442pnl5s	76	12	3712	3712	CD
cord-030504-442pnl5s	76	13	strains	strain	NNS
cord-030504-442pnl5s	76	14	isolated	isolate	VBN
cord-030504-442pnl5s	76	15	in	in	IN
cord-030504-442pnl5s	76	16	China	China	NNP
cord-030504-442pnl5s	76	17	is	be	VBZ
cord-030504-442pnl5s	76	18	H	h	NN
cord-030504-442pnl5s	76	19	(	(	-LRB-
cord-030504-442pnl5s	76	20	histidine	histidine	NNP
cord-030504-442pnl5s	76	21	)	)	-RRB-
cord-030504-442pnl5s	76	22	,	,	,
cord-030504-442pnl5s	76	23	which	which	WDT
cord-030504-442pnl5s	76	24	suggests	suggest	VBZ
cord-030504-442pnl5s	76	25	that	that	IN
cord-030504-442pnl5s	76	26	most	most	JJS
cord-030504-442pnl5s	76	27	of	of	IN
cord-030504-442pnl5s	76	28	the	the	DT
cord-030504-442pnl5s	76	29	viruses	virus	NNS
cord-030504-442pnl5s	76	30	have	have	VBP
cord-030504-442pnl5s	76	31	strong	strong	JJ
cord-030504-442pnl5s	76	32	adsorption	adsorption	NN
cord-030504-442pnl5s	76	33	capacity	capacity	NN
cord-030504-442pnl5s	76	34	to	to	TO
cord-030504-442pnl5s	76	35	host	host	VB
cord-030504-442pnl5s	76	36	cells	cell	NNS
cord-030504-442pnl5s	76	37	.	.	.
cord-030504-442pnl5s	77	1	Furthermore	furthermore	RB
cord-030504-442pnl5s	77	2	,	,	,
cord-030504-442pnl5s	77	3	H22Q	H22Q	NNP
cord-030504-442pnl5s	77	4	was	be	VBD
cord-030504-442pnl5s	77	5	detected	detect	VBN
cord-030504-442pnl5s	77	6	in	in	IN
cord-030504-442pnl5s	77	7	10.99	10.99	CD
cord-030504-442pnl5s	77	8	%	%	NN
cord-030504-442pnl5s	77	9	of	of	IN
cord-030504-442pnl5s	77	10	all	all	DT
cord-030504-442pnl5s	77	11	EV71	EV71	NNP
cord-030504-442pnl5s	77	12	strains	strain	NNS
cord-030504-442pnl5s	77	13	in	in	IN
cord-030504-442pnl5s	77	14	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	77	15	,	,	,
cord-030504-442pnl5s	77	16	significantly	significantly	RB
cord-030504-442pnl5s	77	17	more	more	RBR
cord-030504-442pnl5s	77	18	prevalent	prevalent	JJ
cord-030504-442pnl5s	77	19	than	than	IN
cord-030504-442pnl5s	77	20	that	that	DT
cord-030504-442pnl5s	77	21	in	in	IN
cord-030504-442pnl5s	77	22	mainland	mainland	NN
cord-030504-442pnl5s	77	23	China	China	NNP
cord-030504-442pnl5s	77	24	and	and	CC
cord-030504-442pnl5s	77	25	Hong	Hong	NNP
cord-030504-442pnl5s	77	26	Kong	Kong	NNP
cord-030504-442pnl5s	77	27	(	(	-LRB-
cord-030504-442pnl5s	77	28	5.50	5.50	CD
cord-030504-442pnl5s	77	29	%	%	NN
cord-030504-442pnl5s	77	30	)	)	-RRB-
cord-030504-442pnl5s	77	31	,	,	,
cord-030504-442pnl5s	77	32	suggesting	suggest	VBG
cord-030504-442pnl5s	77	33	that	that	IN
cord-030504-442pnl5s	77	34	the	the	DT
cord-030504-442pnl5s	77	35	adsorption	adsorption	NN
cord-030504-442pnl5s	77	36	capacity	capacity	NN
cord-030504-442pnl5s	77	37	of	of	IN
cord-030504-442pnl5s	77	38	some	some	DT
cord-030504-442pnl5s	77	39	strains	strain	NNS
cord-030504-442pnl5s	77	40	in	in	IN
cord-030504-442pnl5s	77	41	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	77	42	to	to	TO
cord-030504-442pnl5s	77	43	host	host	VB
cord-030504-442pnl5s	77	44	cells	cell	NNS
cord-030504-442pnl5s	77	45	is	be	VBZ
cord-030504-442pnl5s	77	46	weak	weak	JJ
cord-030504-442pnl5s	77	47	in	in	IN
cord-030504-442pnl5s	77	48	comparison	comparison	NN
cord-030504-442pnl5s	77	49	with	with	IN
cord-030504-442pnl5s	77	50	that	that	DT
cord-030504-442pnl5s	77	51	of	of	IN
cord-030504-442pnl5s	77	52	strains	strain	NNS
cord-030504-442pnl5s	77	53	in	in	IN
cord-030504-442pnl5s	77	54	mainland	mainland	NN
cord-030504-442pnl5s	77	55	China	China	NNP
cord-030504-442pnl5s	77	56	.	.	.
cord-030504-442pnl5s	78	1	Studies	study	NNS
cord-030504-442pnl5s	78	2	have	have	VBP
cord-030504-442pnl5s	78	3	shown	show	VBN
cord-030504-442pnl5s	78	4	that	that	IN
cord-030504-442pnl5s	78	5	the	the	DT
cord-030504-442pnl5s	78	6	A289	A289	NNP
cord-030504-442pnl5s	78	7	T	t	NN
cord-030504-442pnl5s	78	8	EV71VP1	ev71vp1	NN
cord-030504-442pnl5s	78	9	variant	variant	NN
cord-030504-442pnl5s	78	10	is	be	VBZ
cord-030504-442pnl5s	78	11	closely	closely	RB
cord-030504-442pnl5s	78	12	related	related	JJ
cord-030504-442pnl5s	78	13	to	to	IN
cord-030504-442pnl5s	78	14	the	the	DT
cord-030504-442pnl5s	78	15	occurrence	occurrence	NN
cord-030504-442pnl5s	78	16	of	of	IN
cord-030504-442pnl5s	78	17	severe	severe	JJ
cord-030504-442pnl5s	78	18	HFMD	HFMD	NNP
cord-030504-442pnl5s	78	19	and	and	CC
cord-030504-442pnl5s	78	20	that	that	IN
cord-030504-442pnl5s	78	21	the	the	DT
cord-030504-442pnl5s	78	22	neurological	neurological	JJ
cord-030504-442pnl5s	78	23	symptoms	symptom	NNS
cord-030504-442pnl5s	78	24	caused	cause	VBN
cord-030504-442pnl5s	78	25	by	by	IN
cord-030504-442pnl5s	78	26	EV71	EV71	NNP
cord-030504-442pnl5s	78	27	infection	infection	NN
cord-030504-442pnl5s	78	28	are	be	VBP
cord-030504-442pnl5s	78	29	significantly	significantly	RB
cord-030504-442pnl5s	78	30	increased	increase	VBN
cord-030504-442pnl5s	78	31	when	when	WRB
cord-030504-442pnl5s	78	32	the	the	DT
cord-030504-442pnl5s	78	33	amino	amino	NN
cord-030504-442pnl5s	78	34	acid	acid	NN
cord-030504-442pnl5s	78	35	at	at	IN
cord-030504-442pnl5s	78	36	position	position	NN
cord-030504-442pnl5s	78	37	289	289	CD
cord-030504-442pnl5s	78	38	of	of	IN
cord-030504-442pnl5s	78	39	VP1	vp1	NN
cord-030504-442pnl5s	78	40	is	be	VBZ
cord-030504-442pnl5s	78	41	A	a	DT
cord-030504-442pnl5s	78	42	(	(	-LRB-
cord-030504-442pnl5s	78	43	alanine	alanine	NN
cord-030504-442pnl5s	78	44	)	)	-RRB-
cord-030504-442pnl5s	78	45	;	;	:
cord-030504-442pnl5s	78	46	in	in	IN
cord-030504-442pnl5s	78	47	contrast	contrast	NN
cord-030504-442pnl5s	78	48	,	,	,
cord-030504-442pnl5s	78	49	there	there	EX
cord-030504-442pnl5s	78	50	is	be	VBZ
cord-030504-442pnl5s	78	51	low	low	JJ
cord-030504-442pnl5s	78	52	neurotoxicity	neurotoxicity	NN
cord-030504-442pnl5s	78	53	when	when	WRB
cord-030504-442pnl5s	78	54	the	the	DT
cord-030504-442pnl5s	78	55	amino	amino	NN
cord-030504-442pnl5s	78	56	acid	acid	NN
cord-030504-442pnl5s	78	57	is	be	VBZ
cord-030504-442pnl5s	78	58	T	T	NNP
cord-030504-442pnl5s	78	59	(	(	-LRB-
cord-030504-442pnl5s	78	60	threonine	threonine	NN
cord-030504-442pnl5s	78	61	)	)	-RRB-
cord-030504-442pnl5s	79	1	[	[	-LRB-
cord-030504-442pnl5s	79	2	36	36	CD
cord-030504-442pnl5s	79	3	,	,	,
cord-030504-442pnl5s	79	4	38	38	CD
cord-030504-442pnl5s	79	5	]	]	-RRB-
cord-030504-442pnl5s	79	6	.	.	.
cord-030504-442pnl5s	80	1	In	in	IN
cord-030504-442pnl5s	80	2	this	this	DT
cord-030504-442pnl5s	80	3	study	study	NN
cord-030504-442pnl5s	80	4	,	,	,
cord-030504-442pnl5s	80	5	76.45	76.45	CD
cord-030504-442pnl5s	80	6	%	%	NN
cord-030504-442pnl5s	80	7	(	(	-LRB-
cord-030504-442pnl5s	80	8	2838	2838	CD
cord-030504-442pnl5s	80	9	strains	strain	NNS
cord-030504-442pnl5s	80	10	)	)	-RRB-
cord-030504-442pnl5s	80	11	of	of	IN
cord-030504-442pnl5s	80	12	the	the	DT
cord-030504-442pnl5s	80	13	virus	virus	NN
cord-030504-442pnl5s	80	14	strains	strain	NNS
cord-030504-442pnl5s	80	15	were	be	VBD
cord-030504-442pnl5s	80	16	found	find	VBN
cord-030504-442pnl5s	80	17	to	to	TO
cord-030504-442pnl5s	80	18	contain	contain	VB
cord-030504-442pnl5s	80	19	an	an	DT
cord-030504-442pnl5s	80	20	A	a	NN
cord-030504-442pnl5s	80	21	(	(	-LRB-
cord-030504-442pnl5s	80	22	alanine	alanine	NN
cord-030504-442pnl5s	80	23	)	)	-RRB-
cord-030504-442pnl5s	80	24	,	,	,
cord-030504-442pnl5s	80	25	suggesting	suggest	VBG
cord-030504-442pnl5s	80	26	that	that	IN
cord-030504-442pnl5s	80	27	most	most	JJS
cord-030504-442pnl5s	80	28	of	of	IN
cord-030504-442pnl5s	80	29	these	these	DT
cord-030504-442pnl5s	80	30	EV71	EV71	NNP
cord-030504-442pnl5s	80	31	viruses	virus	NNS
cord-030504-442pnl5s	80	32	have	have	VBP
cord-030504-442pnl5s	80	33	high	high	JJ
cord-030504-442pnl5s	80	34	neurotoxicity	neurotoxicity	NN
cord-030504-442pnl5s	80	35	.	.	.
cord-030504-442pnl5s	81	1	Moreover	moreover	RB
cord-030504-442pnl5s	81	2	,	,	,
cord-030504-442pnl5s	81	3	10.24	10.24	CD
cord-030504-442pnl5s	81	4	%	%	NN
cord-030504-442pnl5s	81	5	(	(	-LRB-
cord-030504-442pnl5s	81	6	380	380	CD
cord-030504-442pnl5s	81	7	strains	strain	NNS
cord-030504-442pnl5s	81	8	)	)	-RRB-
cord-030504-442pnl5s	81	9	of	of	IN
cord-030504-442pnl5s	81	10	the	the	DT
cord-030504-442pnl5s	81	11	strains	strain	NNS
cord-030504-442pnl5s	81	12	in	in	IN
cord-030504-442pnl5s	81	13	mainland	mainland	NN
cord-030504-442pnl5s	81	14	China	China	NNP
cord-030504-442pnl5s	81	15	(	(	-LRB-
cord-030504-442pnl5s	81	16	including	include	VBG
cord-030504-442pnl5s	81	17	Hong	Hong	NNP
cord-030504-442pnl5s	81	18	Kong	Kong	NNP
cord-030504-442pnl5s	81	19	)	)	-RRB-
cord-030504-442pnl5s	81	20	and	and	CC
cord-030504-442pnl5s	81	21	10.75	10.75	CD
cord-030504-442pnl5s	81	22	%	%	NN
cord-030504-442pnl5s	81	23	(	(	-LRB-
cord-030504-442pnl5s	81	24	399	399	CD
cord-030504-442pnl5s	81	25	strains	strain	NNS
cord-030504-442pnl5s	81	26	)	)	-RRB-
cord-030504-442pnl5s	81	27	of	of	IN
cord-030504-442pnl5s	81	28	those	those	DT
cord-030504-442pnl5s	81	29	in	in	IN
cord-030504-442pnl5s	81	30	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	81	31	contain	contain	VBP
cord-030504-442pnl5s	81	32	a	a	DT
cord-030504-442pnl5s	81	33	T	t	NN
cord-030504-442pnl5s	81	34	(	(	-LRB-
cord-030504-442pnl5s	81	35	threonine	threonine	NN
cord-030504-442pnl5s	81	36	)	)	-RRB-
cord-030504-442pnl5s	81	37	,	,	,
cord-030504-442pnl5s	81	38	suggesting	suggest	VBG
cord-030504-442pnl5s	81	39	low	low	JJ
cord-030504-442pnl5s	81	40	neurotoxicity	neurotoxicity	NN
cord-030504-442pnl5s	81	41	.	.	.
cord-030504-442pnl5s	82	1	It	-PRON-	PRP
cord-030504-442pnl5s	82	2	remains	remain	VBZ
cord-030504-442pnl5s	82	3	to	to	TO
cord-030504-442pnl5s	82	4	be	be	VB
cord-030504-442pnl5s	82	5	further	further	RB
cord-030504-442pnl5s	82	6	studied	study	VBN
cord-030504-442pnl5s	82	7	whether	whether	IN
cord-030504-442pnl5s	82	8	new	new	JJ
cord-030504-442pnl5s	82	9	mutations	mutation	NNS
cord-030504-442pnl5s	82	10	such	such	JJ
cord-030504-442pnl5s	82	11	as	as	IN
cord-030504-442pnl5s	82	12	A289V	A289V	NNP
cord-030504-442pnl5s	82	13	(	(	-LRB-
cord-030504-442pnl5s	82	14	valine)/D	valine)/D	NFP
cord-030504-442pnl5s	82	15	(	(	-LRB-
cord-030504-442pnl5s	82	16	aspartic	aspartic	JJ
cord-030504-442pnl5s	82	17	acid)/I	acid)/i	CD
cord-030504-442pnl5s	83	1	(	(	-LRB-
cord-030504-442pnl5s	83	2	isoleucine	isoleucine	NNP
cord-030504-442pnl5s	83	3	)	)	-RRB-
cord-030504-442pnl5s	84	1	mutations	mutation	NNS
cord-030504-442pnl5s	84	2	will	will	MD
cord-030504-442pnl5s	84	3	cause	cause	VB
cord-030504-442pnl5s	84	4	the	the	DT
cord-030504-442pnl5s	84	5	emergence	emergence	NN
cord-030504-442pnl5s	84	6	of	of	IN
cord-030504-442pnl5s	84	7	severe	severe	JJ
cord-030504-442pnl5s	84	8	HFMD	HFMD	NNP
cord-030504-442pnl5s	84	9	.	.	.
cord-030504-442pnl5s	85	1	EV71	EV71	NNP
cord-030504-442pnl5s	85	2	can	can	MD
cord-030504-442pnl5s	85	3	infect	infect	VB
cord-030504-442pnl5s	85	4	human	human	JJ
cord-030504-442pnl5s	85	5	lymphocytes	lymphocyte	NNS
cord-030504-442pnl5s	85	6	by	by	IN
cord-030504-442pnl5s	85	7	binding	bind	VBG
cord-030504-442pnl5s	85	8	to	to	IN
cord-030504-442pnl5s	85	9	its	-PRON-	PRP$
cord-030504-442pnl5s	85	10	receptor	receptor	NN
cord-030504-442pnl5s	85	11	molecule	molecule	NN
cord-030504-442pnl5s	85	12	P	p	NN
cord-030504-442pnl5s	85	13	-	-	HYPH
cord-030504-442pnl5s	85	14	selectin	selectin	NN
cord-030504-442pnl5s	85	15	glycoprotein	glycoprotein	NN
cord-030504-442pnl5s	85	16	ligand-1	ligand-1	NNP
cord-030504-442pnl5s	85	17	(	(	-LRB-
cord-030504-442pnl5s	85	18	PSGL-1	psgl-1	NN
cord-030504-442pnl5s	85	19	)	)	-RRB-
cord-030504-442pnl5s	85	20	.	.	.
cord-030504-442pnl5s	86	1	When	when	WRB
cord-030504-442pnl5s	86	2	E	e	NN
cord-030504-442pnl5s	86	3	(	(	-LRB-
cord-030504-442pnl5s	86	4	glutamic	glutamic	JJ
cord-030504-442pnl5s	86	5	acid	acid	NN
cord-030504-442pnl5s	86	6	)	)	-RRB-
cord-030504-442pnl5s	86	7	at	at	IN
cord-030504-442pnl5s	86	8	position	position	NN
cord-030504-442pnl5s	86	9	145	145	CD
cord-030504-442pnl5s	86	10	in	in	IN
cord-030504-442pnl5s	86	11	VP1	VP1	NNP
cord-030504-442pnl5s	86	12	is	be	VBZ
cord-030504-442pnl5s	86	13	mutated	mutate	VBN
cord-030504-442pnl5s	86	14	to	to	IN
cord-030504-442pnl5s	86	15	G	g	NN
cord-030504-442pnl5s	86	16	(	(	-LRB-
cord-030504-442pnl5s	86	17	glycine	glycine	NN
cord-030504-442pnl5s	86	18	)	)	-RRB-
cord-030504-442pnl5s	86	19	or	or	CC
cord-030504-442pnl5s	86	20	Q	Q	NNP
cord-030504-442pnl5s	86	21	(	(	-LRB-
cord-030504-442pnl5s	86	22	glutamine	glutamine	NN
cord-030504-442pnl5s	86	23	)	)	-RRB-
cord-030504-442pnl5s	86	24	,	,	,
cord-030504-442pnl5s	86	25	the	the	DT
cord-030504-442pnl5s	86	26	virus	virus	NN
cord-030504-442pnl5s	86	27	binds	bind	VBZ
cord-030504-442pnl5s	86	28	PSGL-1	psgl-1	PRP
cord-030504-442pnl5s	86	29	more	more	RBR
cord-030504-442pnl5s	86	30	readily	readily	RB
cord-030504-442pnl5s	86	31	,	,	,
cord-030504-442pnl5s	86	32	whereas	whereas	IN
cord-030504-442pnl5s	86	33	its	-PRON-	PRP$
cord-030504-442pnl5s	86	34	PSGL-1-binding	psgl-1-binding	NN
cord-030504-442pnl5s	86	35	ability	ability	NN
cord-030504-442pnl5s	86	36	is	be	VBZ
cord-030504-442pnl5s	86	37	weakened	weaken	VBN
cord-030504-442pnl5s	86	38	or	or	CC
cord-030504-442pnl5s	86	39	lost	lose	VBN
cord-030504-442pnl5s	86	40	when	when	WRB
cord-030504-442pnl5s	86	41	E	E	NNP
cord-030504-442pnl5s	86	42	is	be	VBZ
cord-030504-442pnl5s	86	43	present	present	JJ
cord-030504-442pnl5s	86	44	[	[	-LRB-
cord-030504-442pnl5s	86	45	39	39	CD
cord-030504-442pnl5s	86	46	]	]	-RRB-
cord-030504-442pnl5s	86	47	.	.	.
cord-030504-442pnl5s	87	1	In	in	IN
cord-030504-442pnl5s	87	2	this	this	DT
cord-030504-442pnl5s	87	3	study	study	NN
cord-030504-442pnl5s	87	4	,	,	,
cord-030504-442pnl5s	87	5	the	the	DT
cord-030504-442pnl5s	87	6	amino	amino	NN
cord-030504-442pnl5s	87	7	acid	acid	NN
cord-030504-442pnl5s	87	8	at	at	IN
cord-030504-442pnl5s	87	9	position	position	NN
cord-030504-442pnl5s	87	10	145	145	CD
cord-030504-442pnl5s	87	11	in	in	IN
cord-030504-442pnl5s	87	12	most	most	JJS
cord-030504-442pnl5s	87	13	strains	strain	NNS
cord-030504-442pnl5s	87	14	was	be	VBD
cord-030504-442pnl5s	87	15	found	find	VBN
cord-030504-442pnl5s	87	16	to	to	TO
cord-030504-442pnl5s	87	17	be	be	VB
cord-030504-442pnl5s	87	18	E	E	NNP
cord-030504-442pnl5s	87	19	,	,	,
cord-030504-442pnl5s	87	20	with	with	IN
cord-030504-442pnl5s	87	21	an	an	DT
cord-030504-442pnl5s	87	22	E145G	E145G	NNP
cord-030504-442pnl5s	87	23	/	/	SYM
cord-030504-442pnl5s	87	24	Q	q	NN
cord-030504-442pnl5s	87	25	mutation	mutation	NN
cord-030504-442pnl5s	87	26	rate	rate	NN
cord-030504-442pnl5s	87	27	of	of	IN
cord-030504-442pnl5s	87	28	6.63	6.63	CD
cord-030504-442pnl5s	87	29	%	%	NN
cord-030504-442pnl5s	87	30	,	,	,
cord-030504-442pnl5s	87	31	suggesting	suggest	VBG
cord-030504-442pnl5s	87	32	that	that	IN
cord-030504-442pnl5s	87	33	the	the	DT
cord-030504-442pnl5s	87	34	emergence	emergence	NN
cord-030504-442pnl5s	87	35	of	of	IN
cord-030504-442pnl5s	87	36	this	this	DT
cord-030504-442pnl5s	87	37	mutation	mutation	NN
cord-030504-442pnl5s	87	38	may	may	MD
cord-030504-442pnl5s	87	39	result	result	VB
cord-030504-442pnl5s	87	40	in	in	IN
cord-030504-442pnl5s	87	41	a	a	DT
cord-030504-442pnl5s	87	42	virus	virus	NN
cord-030504-442pnl5s	87	43	that	that	WDT
cord-030504-442pnl5s	87	44	is	be	VBZ
cord-030504-442pnl5s	87	45	more	more	RBR
cord-030504-442pnl5s	87	46	likely	likely	JJ
cord-030504-442pnl5s	87	47	to	to	TO
cord-030504-442pnl5s	87	48	infect	infect	VB
cord-030504-442pnl5s	87	49	human	human	JJ
cord-030504-442pnl5s	87	50	lymphocytes	lymphocyte	NNS
cord-030504-442pnl5s	87	51	.	.	.
cord-030504-442pnl5s	88	1	It	-PRON-	PRP
cord-030504-442pnl5s	88	2	has	have	VBZ
cord-030504-442pnl5s	88	3	been	be	VBN
cord-030504-442pnl5s	88	4	reported	report	VBN
cord-030504-442pnl5s	88	5	that	that	IN
cord-030504-442pnl5s	88	6	the	the	DT
cord-030504-442pnl5s	88	7	E98	E98	NNP
cord-030504-442pnl5s	88	8	K	K	NNP
cord-030504-442pnl5s	88	9	mutation	mutation	NN
cord-030504-442pnl5s	88	10	may	may	MD
cord-030504-442pnl5s	88	11	increase	increase	VB
cord-030504-442pnl5s	88	12	the	the	DT
cord-030504-442pnl5s	88	13	hydrophobicity	hydrophobicity	NN
cord-030504-442pnl5s	88	14	of	of	IN
cord-030504-442pnl5s	88	15	VP1	VP1	NNP
cord-030504-442pnl5s	88	16	,	,	,
cord-030504-442pnl5s	88	17	making	make	VBG
cord-030504-442pnl5s	88	18	it	-PRON-	PRP
cord-030504-442pnl5s	88	19	easy	easy	JJ
cord-030504-442pnl5s	88	20	for	for	IN
cord-030504-442pnl5s	88	21	large	large	JJ
cord-030504-442pnl5s	88	22	compounds	compound	NNS
cord-030504-442pnl5s	88	23	to	to	TO
cord-030504-442pnl5s	88	24	enter	enter	VB
cord-030504-442pnl5s	88	25	and	and	CC
cord-030504-442pnl5s	88	26	interfere	interfere	VB
cord-030504-442pnl5s	88	27	with	with	IN
cord-030504-442pnl5s	88	28	receptor	receptor	NN
cord-030504-442pnl5s	88	29	binding	binding	NN
cord-030504-442pnl5s	88	30	,	,	,
cord-030504-442pnl5s	88	31	suggesting	suggest	VBG
cord-030504-442pnl5s	88	32	that	that	IN
cord-030504-442pnl5s	88	33	E98	E98	NNP
cord-030504-442pnl5s	88	34	K	K	NNP
cord-030504-442pnl5s	88	35	mutant	mutant	NN
cord-030504-442pnl5s	88	36	viruses	virus	NNS
cord-030504-442pnl5s	88	37	are	be	VBP
cord-030504-442pnl5s	88	38	sensitive	sensitive	JJ
cord-030504-442pnl5s	88	39	to	to	IN
cord-030504-442pnl5s	88	40	larger	large	JJR
cord-030504-442pnl5s	88	41	compounds	compound	NNS
cord-030504-442pnl5s	88	42	[	[	-LRB-
cord-030504-442pnl5s	88	43	40	40	CD
cord-030504-442pnl5s	88	44	]	]	-RRB-
cord-030504-442pnl5s	88	45	.	.	.
cord-030504-442pnl5s	89	1	Other	other	JJ
cord-030504-442pnl5s	89	2	studies	study	NNS
cord-030504-442pnl5s	89	3	have	have	VBP
cord-030504-442pnl5s	89	4	shown	show	VBN
cord-030504-442pnl5s	89	5	that	that	IN
cord-030504-442pnl5s	89	6	E145	E145	``
cord-030504-442pnl5s	89	7	G	g	NN
cord-030504-442pnl5s	89	8	and	and	CC
cord-030504-442pnl5s	89	9	N31D	n31d	NN
cord-030504-442pnl5s	89	10	mutations	mutation	NNS
cord-030504-442pnl5s	89	11	are	be	VBP
cord-030504-442pnl5s	89	12	associated	associate	VBN
cord-030504-442pnl5s	89	13	with	with	IN
cord-030504-442pnl5s	89	14	increased	increase	VBN
cord-030504-442pnl5s	89	15	virulence	virulence	NN
cord-030504-442pnl5s	89	16	of	of	IN
cord-030504-442pnl5s	89	17	EV71	EV71	NNP
cord-030504-442pnl5s	89	18	and	and	CC
cord-030504-442pnl5s	89	19	may	may	MD
cord-030504-442pnl5s	89	20	increase	increase	VB
cord-030504-442pnl5s	89	21	the	the	DT
cord-030504-442pnl5s	89	22	risk	risk	NN
cord-030504-442pnl5s	89	23	of	of	IN
cord-030504-442pnl5s	89	24	neurological	neurological	JJ
cord-030504-442pnl5s	89	25	complications	complication	NNS
cord-030504-442pnl5s	89	26	but	but	CC
cord-030504-442pnl5s	89	27	that	that	IN
cord-030504-442pnl5s	89	28	I262V	I262V	NNP
cord-030504-442pnl5s	89	29	mutations	mutation	NNS
cord-030504-442pnl5s	89	30	reduce	reduce	VBP
cord-030504-442pnl5s	89	31	the	the	DT
cord-030504-442pnl5s	89	32	risk	risk	NN
cord-030504-442pnl5s	89	33	of	of	IN
cord-030504-442pnl5s	89	34	neurological	neurological	JJ
cord-030504-442pnl5s	89	35	complications	complication	NNS
cord-030504-442pnl5s	89	36	[	[	-LRB-
cord-030504-442pnl5s	89	37	41	41	CD
cord-030504-442pnl5s	89	38	]	]	-RRB-
cord-030504-442pnl5s	89	39	[	[	-LRB-
cord-030504-442pnl5s	89	40	42	42	CD
cord-030504-442pnl5s	89	41	]	]	-RRB-
cord-030504-442pnl5s	89	42	[	[	-LRB-
cord-030504-442pnl5s	89	43	43	43	CD
cord-030504-442pnl5s	89	44	]	]	-RRB-
cord-030504-442pnl5s	89	45	.	.	.
cord-030504-442pnl5s	90	1	In	in	IN
cord-030504-442pnl5s	90	2	this	this	DT
cord-030504-442pnl5s	90	3	study	study	NN
cord-030504-442pnl5s	90	4	,	,	,
cord-030504-442pnl5s	90	5	the	the	DT
cord-030504-442pnl5s	90	6	E98	E98	NNP
cord-030504-442pnl5s	90	7	K	K	NNP
cord-030504-442pnl5s	90	8	,	,	,
cord-030504-442pnl5s	90	9	E145	E145	''
cord-030504-442pnl5s	90	10	G	g	NN
cord-030504-442pnl5s	90	11	,	,	,
cord-030504-442pnl5s	90	12	N31D	n31d	NN
cord-030504-442pnl5s	90	13	and	and	CC
cord-030504-442pnl5s	90	14	I262V	I262V	NNP
cord-030504-442pnl5s	90	15	mutation	mutation	NN
cord-030504-442pnl5s	90	16	rates	rate	NNS
cord-030504-442pnl5s	90	17	were	be	VBD
cord-030504-442pnl5s	90	18	6.65	6.65	CD
cord-030504-442pnl5s	90	19	%	%	NN
cord-030504-442pnl5s	90	20	,	,	,
cord-030504-442pnl5s	90	21	3.13	3.13	CD
cord-030504-442pnl5s	90	22	%	%	NN
cord-030504-442pnl5s	90	23	,	,	,
cord-030504-442pnl5s	90	24	7.25	7.25	CD
cord-030504-442pnl5s	90	25	%	%	NN
cord-030504-442pnl5s	90	26	and	and	CC
cord-030504-442pnl5s	90	27	2.77	2.77	CD
cord-030504-442pnl5s	90	28	%	%	NN
cord-030504-442pnl5s	90	29	,	,	,
cord-030504-442pnl5s	90	30	respectively	respectively	RB
cord-030504-442pnl5s	90	31	.	.	.
cord-030504-442pnl5s	91	1	These	these	DT
cord-030504-442pnl5s	91	2	findings	finding	NNS
cord-030504-442pnl5s	91	3	indicate	indicate	VBP
cord-030504-442pnl5s	91	4	that	that	IN
cord-030504-442pnl5s	91	5	these	these	DT
cord-030504-442pnl5s	91	6	mutations	mutation	NNS
cord-030504-442pnl5s	91	7	may	may	MD
cord-030504-442pnl5s	91	8	play	play	VB
cord-030504-442pnl5s	91	9	an	an	DT
cord-030504-442pnl5s	91	10	important	important	JJ
cord-030504-442pnl5s	91	11	role	role	NN
cord-030504-442pnl5s	91	12	in	in	IN
cord-030504-442pnl5s	91	13	the	the	DT
cord-030504-442pnl5s	91	14	pathogenicity	pathogenicity	NN
cord-030504-442pnl5s	91	15	of	of	IN
cord-030504-442pnl5s	91	16	mild	mild	JJ
cord-030504-442pnl5s	91	17	and	and	CC
cord-030504-442pnl5s	91	18	severe	severe	JJ
cord-030504-442pnl5s	91	19	EV71-associated	EV71-associated	NNP
cord-030504-442pnl5s	91	20	HFMD	HFMD	NNP
cord-030504-442pnl5s	91	21	.	.	.
cord-030504-442pnl5s	92	1	Humans	human	NNS
cord-030504-442pnl5s	92	2	are	be	VBP
cord-030504-442pnl5s	92	3	the	the	DT
cord-030504-442pnl5s	92	4	only	only	JJ
cord-030504-442pnl5s	92	5	natural	natural	JJ
cord-030504-442pnl5s	92	6	host	host	NN
cord-030504-442pnl5s	92	7	and	and	CC
cord-030504-442pnl5s	92	8	source	source	NN
cord-030504-442pnl5s	92	9	of	of	IN
cord-030504-442pnl5s	92	10	EV71	EV71	NNP
cord-030504-442pnl5s	92	11	.	.	.
cord-030504-442pnl5s	93	1	Indeed	indeed	RB
cord-030504-442pnl5s	93	2	,	,	,
cord-030504-442pnl5s	93	3	EV71	EV71	NNP
cord-030504-442pnl5s	93	4	can	can	MD
cord-030504-442pnl5s	93	5	not	not	RB
cord-030504-442pnl5s	93	6	infect	infect	VB
cord-030504-442pnl5s	93	7	rodents	rodent	NNS
cord-030504-442pnl5s	93	8	,	,	,
cord-030504-442pnl5s	93	9	which	which	WDT
cord-030504-442pnl5s	93	10	is	be	VBZ
cord-030504-442pnl5s	93	11	due	due	JJ
cord-030504-442pnl5s	93	12	mainly	mainly	RB
cord-030504-442pnl5s	93	13	to	to	IN
cord-030504-442pnl5s	93	14	the	the	DT
cord-030504-442pnl5s	93	15	incompatibility	incompatibility	NN
cord-030504-442pnl5s	93	16	between	between	IN
cord-030504-442pnl5s	93	17	the	the	DT
cord-030504-442pnl5s	93	18	virus	virus	NN
cord-030504-442pnl5s	93	19	and	and	CC
cord-030504-442pnl5s	93	20	rodent	rodent	NN
cord-030504-442pnl5s	93	21	cells	cell	NNS
cord-030504-442pnl5s	93	22	,	,	,
cord-030504-442pnl5s	93	23	and	and	CC
cord-030504-442pnl5s	93	24	the	the	DT
cord-030504-442pnl5s	93	25	different	different	JJ
cord-030504-442pnl5s	93	26	expression	expression	NN
cord-030504-442pnl5s	93	27	of	of	IN
cord-030504-442pnl5s	93	28	its	-PRON-	PRP$
cord-030504-442pnl5s	93	29	scavenger	scavenger	NN
cord-030504-442pnl5s	93	30	receptor	receptor	NN
cord-030504-442pnl5s	93	31	in	in	IN
cord-030504-442pnl5s	93	32	humans	human	NNS
cord-030504-442pnl5s	93	33	and	and	CC
cord-030504-442pnl5s	93	34	rodents	rodent	NNS
cord-030504-442pnl5s	93	35	[	[	-LRB-
cord-030504-442pnl5s	93	36	44	44	CD
cord-030504-442pnl5s	93	37	]	]	-RRB-
cord-030504-442pnl5s	93	38	[	[	-LRB-
cord-030504-442pnl5s	93	39	45	45	CD
cord-030504-442pnl5s	93	40	]	]	-RRB-
cord-030504-442pnl5s	93	41	[	[	-LRB-
cord-030504-442pnl5s	93	42	46	46	CD
cord-030504-442pnl5s	93	43	]	]	-RRB-
cord-030504-442pnl5s	93	44	.	.	.
cord-030504-442pnl5s	94	1	However	however	RB
cord-030504-442pnl5s	94	2	,	,	,
cord-030504-442pnl5s	94	3	some	some	DT
cord-030504-442pnl5s	94	4	studies	study	NNS
cord-030504-442pnl5s	94	5	have	have	VBP
cord-030504-442pnl5s	94	6	found	find	VBN
cord-030504-442pnl5s	94	7	that	that	IN
cord-030504-442pnl5s	94	8	simultaneous	simultaneous	JJ
cord-030504-442pnl5s	94	9	substitution	substitution	NN
cord-030504-442pnl5s	94	10	of	of	IN
cord-030504-442pnl5s	94	11	K98E	K98E	NNP
cord-030504-442pnl5s	94	12	,	,	,
cord-030504-442pnl5s	94	13	E145A	E145A	NNP
cord-030504-442pnl5s	94	14	and	and	CC
cord-030504-442pnl5s	94	15	L169F	L169F	NNP
cord-030504-442pnl5s	94	16	in	in	IN
cord-030504-442pnl5s	94	17	VP1	vp1	NN
cord-030504-442pnl5s	94	18	of	of	IN
cord-030504-442pnl5s	94	19	EV71	EV71	NNP
cord-030504-442pnl5s	94	20	can	can	MD
cord-030504-442pnl5s	94	21	result	result	VB
cord-030504-442pnl5s	94	22	in	in	IN
cord-030504-442pnl5s	94	23	infection	infection	NN
cord-030504-442pnl5s	94	24	in	in	IN
cord-030504-442pnl5s	94	25	mice	mouse	NNS
cord-030504-442pnl5s	94	26	[	[	-LRB-
cord-030504-442pnl5s	94	27	44	44	CD
cord-030504-442pnl5s	94	28	]	]	-RRB-
cord-030504-442pnl5s	94	29	.	.	.
cord-030504-442pnl5s	95	1	Our	-PRON-	PRP$
cord-030504-442pnl5s	95	2	study	study	NN
cord-030504-442pnl5s	95	3	showed	show	VBD
cord-030504-442pnl5s	95	4	that	that	IN
cord-030504-442pnl5s	95	5	among	among	IN
cord-030504-442pnl5s	95	6	3712	3712	CD
cord-030504-442pnl5s	95	7	strains	strain	NNS
cord-030504-442pnl5s	95	8	,	,	,
cord-030504-442pnl5s	95	9	the	the	DT
cord-030504-442pnl5s	95	10	mutation	mutation	NN
cord-030504-442pnl5s	95	11	frequencies	frequency	NNS
cord-030504-442pnl5s	95	12	of	of	IN
cord-030504-442pnl5s	95	13	K98E	K98E	NNP
cord-030504-442pnl5s	95	14	,	,	,
cord-030504-442pnl5s	95	15	E145A	E145A	NNP
cord-030504-442pnl5s	95	16	and	and	CC
cord-030504-442pnl5s	95	17	L169F	L169F	NNP
cord-030504-442pnl5s	95	18	were	be	VBD
cord-030504-442pnl5s	95	19	93.24	93.24	CD
cord-030504-442pnl5s	95	20	%	%	NN
cord-030504-442pnl5s	95	21	,	,	,
cord-030504-442pnl5s	95	22	0.30	0.30	CD
cord-030504-442pnl5s	95	23	%	%	NN
cord-030504-442pnl5s	95	24	and	and	CC
cord-030504-442pnl5s	95	25	0.03	0.03	CD
cord-030504-442pnl5s	95	26	%	%	NN
cord-030504-442pnl5s	95	27	,	,	,
cord-030504-442pnl5s	95	28	respectively	respectively	RB
cord-030504-442pnl5s	95	29	;	;	:
cord-030504-442pnl5s	95	30	however	however	RB
cord-030504-442pnl5s	95	31	,	,	,
cord-030504-442pnl5s	95	32	no	no	DT
cord-030504-442pnl5s	95	33	strain	strain	NN
cord-030504-442pnl5s	95	34	with	with	IN
cord-030504-442pnl5s	95	35	all	all	DT
cord-030504-442pnl5s	95	36	three	three	CD
cord-030504-442pnl5s	95	37	mutations	mutation	NNS
cord-030504-442pnl5s	95	38	was	be	VBD
cord-030504-442pnl5s	95	39	found	find	VBN
cord-030504-442pnl5s	95	40	.	.	.
cord-030504-442pnl5s	96	1	These	these	DT
cord-030504-442pnl5s	96	2	findings	finding	NNS
cord-030504-442pnl5s	96	3	indicate	indicate	VBP
cord-030504-442pnl5s	96	4	that	that	IN
cord-030504-442pnl5s	96	5	humans	human	NNS
cord-030504-442pnl5s	96	6	are	be	VBP
cord-030504-442pnl5s	96	7	still	still	RB
cord-030504-442pnl5s	96	8	the	the	DT
cord-030504-442pnl5s	96	9	only	only	JJ
cord-030504-442pnl5s	96	10	host	host	NN
cord-030504-442pnl5s	96	11	of	of	IN
cord-030504-442pnl5s	96	12	EV71	EV71	NNP
cord-030504-442pnl5s	96	13	in	in	IN
cord-030504-442pnl5s	96	14	China	China	NNP
cord-030504-442pnl5s	96	15	;	;	:
cord-030504-442pnl5s	96	16	nevertheless	nevertheless	RB
cord-030504-442pnl5s	96	17	,	,	,
cord-030504-442pnl5s	96	18	the	the	DT
cord-030504-442pnl5s	96	19	existence	existence	NN
cord-030504-442pnl5s	96	20	of	of	IN
cord-030504-442pnl5s	96	21	individual	individual	JJ
cord-030504-442pnl5s	96	22	mutations	mutation	NNS
cord-030504-442pnl5s	96	23	does	do	VBZ
cord-030504-442pnl5s	96	24	not	not	RB
cord-030504-442pnl5s	96	25	rule	rule	VB
cord-030504-442pnl5s	96	26	out	out	RP
cord-030504-442pnl5s	96	27	the	the	DT
cord-030504-442pnl5s	96	28	emergence	emergence	NN
cord-030504-442pnl5s	96	29	over	over	IN
cord-030504-442pnl5s	96	30	time	time	NN
cord-030504-442pnl5s	96	31	of	of	IN
cord-030504-442pnl5s	96	32	strains	strain	NNS
cord-030504-442pnl5s	96	33	that	that	WDT
cord-030504-442pnl5s	96	34	can	can	MD
cord-030504-442pnl5s	96	35	infect	infect	VB
cord-030504-442pnl5s	96	36	other	other	JJ
cord-030504-442pnl5s	96	37	mammals	mammal	NNS
cord-030504-442pnl5s	96	38	.	.	.
cord-030504-442pnl5s	97	1	Therefore	therefore	RB
cord-030504-442pnl5s	97	2	,	,	,
cord-030504-442pnl5s	97	3	it	-PRON-	PRP
cord-030504-442pnl5s	97	4	is	be	VBZ
cord-030504-442pnl5s	97	5	important	important	JJ
cord-030504-442pnl5s	97	6	to	to	TO
cord-030504-442pnl5s	97	7	closely	closely	RB
cord-030504-442pnl5s	97	8	monitor	monitor	VB
cord-030504-442pnl5s	97	9	mutation	mutation	NN
cord-030504-442pnl5s	97	10	of	of	IN
cord-030504-442pnl5s	97	11	the	the	DT
cord-030504-442pnl5s	97	12	key	key	JJ
cord-030504-442pnl5s	97	13	sites	site	NNS
cord-030504-442pnl5s	97	14	of	of	IN
cord-030504-442pnl5s	97	15	the	the	DT
cord-030504-442pnl5s	97	16	EV71VP1	ev71vp1	NN
cord-030504-442pnl5s	97	17	protein	protein	NN
cord-030504-442pnl5s	97	18	.	.	.
cord-030504-442pnl5s	98	1	EV71	EV71	NNP
cord-030504-442pnl5s	98	2	is	be	VBZ
cord-030504-442pnl5s	98	3	the	the	DT
cord-030504-442pnl5s	98	4	most	most	RBS
cord-030504-442pnl5s	98	5	important	important	JJ
cord-030504-442pnl5s	98	6	pathogen	pathogen	NN
cord-030504-442pnl5s	98	7	causing	cause	VBG
cord-030504-442pnl5s	98	8	severe	severe	JJ
cord-030504-442pnl5s	98	9	HFMD	hfmd	NN
cord-030504-442pnl5s	98	10	in	in	IN
cord-030504-442pnl5s	98	11	children	child	NNS
cord-030504-442pnl5s	98	12	,	,	,
cord-030504-442pnl5s	98	13	which	which	WDT
cord-030504-442pnl5s	98	14	can	can	MD
cord-030504-442pnl5s	98	15	lead	lead	VB
cord-030504-442pnl5s	98	16	to	to	IN
cord-030504-442pnl5s	98	17	irreversible	irreversible	JJ
cord-030504-442pnl5s	98	18	sequelae	sequela	NNS
cord-030504-442pnl5s	98	19	or	or	CC
cord-030504-442pnl5s	98	20	death	death	NN
cord-030504-442pnl5s	98	21	,	,	,
cord-030504-442pnl5s	98	22	and	and	CC
cord-030504-442pnl5s	98	23	it	-PRON-	PRP
cord-030504-442pnl5s	98	24	is	be	VBZ
cord-030504-442pnl5s	98	25	a	a	DT
cord-030504-442pnl5s	98	26	serious	serious	JJ
cord-030504-442pnl5s	98	27	threat	threat	NN
cord-030504-442pnl5s	98	28	to	to	IN
cord-030504-442pnl5s	98	29	their	-PRON-	PRP$
cord-030504-442pnl5s	98	30	health	health	NN
cord-030504-442pnl5s	98	31	[	[	-LRB-
cord-030504-442pnl5s	98	32	4	4	CD
cord-030504-442pnl5s	98	33	,	,	,
cord-030504-442pnl5s	98	34	7	7	CD
cord-030504-442pnl5s	98	35	]	]	-RRB-
cord-030504-442pnl5s	98	36	.	.	.
cord-030504-442pnl5s	99	1	At	at	IN
cord-030504-442pnl5s	99	2	present	present	JJ
cord-030504-442pnl5s	99	3	,	,	,
cord-030504-442pnl5s	99	4	there	there	EX
cord-030504-442pnl5s	99	5	is	be	VBZ
cord-030504-442pnl5s	99	6	no	no	DT
cord-030504-442pnl5s	99	7	specific	specific	JJ
cord-030504-442pnl5s	99	8	treatment	treatment	NN
cord-030504-442pnl5s	99	9	for	for	IN
cord-030504-442pnl5s	99	10	EV71	EV71	NNP
cord-030504-442pnl5s	99	11	infection	infection	NN
cord-030504-442pnl5s	99	12	.	.	.
cord-030504-442pnl5s	100	1	The	the	DT
cord-030504-442pnl5s	100	2	development	development	NN
cord-030504-442pnl5s	100	3	and	and	CC
cord-030504-442pnl5s	100	4	marketing	marketing	NN
cord-030504-442pnl5s	100	5	of	of	IN
cord-030504-442pnl5s	100	6	an	an	DT
cord-030504-442pnl5s	100	7	inactivated	inactivated	JJ
cord-030504-442pnl5s	100	8	EV71	EV71	NNP
cord-030504-442pnl5s	100	9	vaccine	vaccine	NN
cord-030504-442pnl5s	100	10	in	in	IN
cord-030504-442pnl5s	100	11	China	China	NNP
cord-030504-442pnl5s	100	12	is	be	VBZ
cord-030504-442pnl5s	100	13	crucial	crucial	JJ
cord-030504-442pnl5s	100	14	for	for	IN
cord-030504-442pnl5s	100	15	the	the	DT
cord-030504-442pnl5s	100	16	prevention	prevention	NN
cord-030504-442pnl5s	100	17	of	of	IN
cord-030504-442pnl5s	100	18	HFMD	HFMD	NNP
cord-030504-442pnl5s	100	19	caused	cause	VBN
cord-030504-442pnl5s	100	20	by	by	IN
cord-030504-442pnl5s	100	21	EV71	EV71	NNP
cord-030504-442pnl5s	100	22	infection	infection	NN
cord-030504-442pnl5s	100	23	[	[	-LRB-
cord-030504-442pnl5s	100	24	26	26	CD
cord-030504-442pnl5s	100	25	,	,	,
cord-030504-442pnl5s	100	26	[	[	-LRB-
cord-030504-442pnl5s	100	27	47	47	CD
cord-030504-442pnl5s	100	28	]	]	-RRB-
cord-030504-442pnl5s	100	29	[	[	-LRB-
cord-030504-442pnl5s	100	30	48	48	CD
cord-030504-442pnl5s	100	31	]	]	-RRB-
cord-030504-442pnl5s	100	32	[	[	-LRB-
cord-030504-442pnl5s	100	33	49	49	CD
cord-030504-442pnl5s	100	34	]	]	-RRB-
cord-030504-442pnl5s	100	35	.	.	.
cord-030504-442pnl5s	101	1	Phase	phase	NN
cord-030504-442pnl5s	101	2	III	iii	CD
cord-030504-442pnl5s	101	3	clinical	clinical	JJ
cord-030504-442pnl5s	101	4	trials	trial	NNS
cord-030504-442pnl5s	101	5	of	of	IN
cord-030504-442pnl5s	101	6	the	the	DT
cord-030504-442pnl5s	101	7	EV71	EV71	NNP
cord-030504-442pnl5s	101	8	inactivated	inactivate	VBN
cord-030504-442pnl5s	101	9	vaccine	vaccine	NN
cord-030504-442pnl5s	101	10	approved	approve	VBN
cord-030504-442pnl5s	101	11	in	in	IN
cord-030504-442pnl5s	101	12	China	China	NNP
cord-030504-442pnl5s	101	13	in	in	IN
cord-030504-442pnl5s	101	14	2015	2015	CD
cord-030504-442pnl5s	101	15	have	have	VBP
cord-030504-442pnl5s	101	16	shown	show	VBN
cord-030504-442pnl5s	101	17	protective	protective	JJ
cord-030504-442pnl5s	101	18	effectiveness	effectiveness	NN
cord-030504-442pnl5s	101	19	against	against	IN
cord-030504-442pnl5s	101	20	EV71-associated	EV71-associated	NNP
cord-030504-442pnl5s	101	21	HFMD	HFMD	NNP
cord-030504-442pnl5s	101	22	of	of	IN
cord-030504-442pnl5s	101	23	more	more	JJR
cord-030504-442pnl5s	101	24	than	than	IN
cord-030504-442pnl5s	101	25	90	90	CD
cord-030504-442pnl5s	101	26	%	%	NN
cord-030504-442pnl5s	101	27	[	[	-LRB-
cord-030504-442pnl5s	101	28	47	47	CD
cord-030504-442pnl5s	101	29	,	,	,
cord-030504-442pnl5s	101	30	[	[	-LRB-
cord-030504-442pnl5s	101	31	50	50	CD
cord-030504-442pnl5s	101	32	]	]	-RRB-
cord-030504-442pnl5s	101	33	[	[	-LRB-
cord-030504-442pnl5s	101	34	51	51	CD
cord-030504-442pnl5s	101	35	]	]	-RRB-
cord-030504-442pnl5s	101	36	[	[	-LRB-
cord-030504-442pnl5s	101	37	52	52	CD
cord-030504-442pnl5s	101	38	]	]	-RRB-
cord-030504-442pnl5s	101	39	.	.	.
cord-030504-442pnl5s	102	1	However	however	RB
cord-030504-442pnl5s	102	2	,	,	,
cord-030504-442pnl5s	102	3	according	accord	VBG
cord-030504-442pnl5s	102	4	to	to	IN
cord-030504-442pnl5s	102	5	molecular	molecular	JJ
cord-030504-442pnl5s	102	6	epidemiological	epidemiological	JJ
cord-030504-442pnl5s	102	7	studies	study	NNS
cord-030504-442pnl5s	102	8	of	of	IN
cord-030504-442pnl5s	102	9	EV71	EV71	NNP
cord-030504-442pnl5s	102	10	,	,	,
cord-030504-442pnl5s	102	11	EV71	EV71	NNP
cord-030504-442pnl5s	102	12	gene	gene	NN
cord-030504-442pnl5s	102	13	mutations	mutation	NNS
cord-030504-442pnl5s	102	14	occur	occur	VBP
cord-030504-442pnl5s	102	15	frequently	frequently	RB
cord-030504-442pnl5s	102	16	,	,	,
cord-030504-442pnl5s	102	17	leading	lead	VBG
cord-030504-442pnl5s	102	18	to	to	IN
cord-030504-442pnl5s	102	19	genetic	genetic	JJ
cord-030504-442pnl5s	102	20	diversity	diversity	NN
cord-030504-442pnl5s	102	21	[	[	-LRB-
cord-030504-442pnl5s	102	22	28	28	CD
cord-030504-442pnl5s	102	23	]	]	-RRB-
cord-030504-442pnl5s	103	1	[	[	-LRB-
cord-030504-442pnl5s	103	2	29	29	CD
cord-030504-442pnl5s	103	3	]	]	-RRB-
cord-030504-442pnl5s	104	1	[	[	-LRB-
cord-030504-442pnl5s	104	2	30	30	CD
cord-030504-442pnl5s	104	3	]	]	-RRB-
cord-030504-442pnl5s	104	4	[	[	-LRB-
cord-030504-442pnl5s	104	5	31	31	CD
cord-030504-442pnl5s	104	6	]	]	-RRB-
cord-030504-442pnl5s	104	7	53	53	CD
cord-030504-442pnl5s	104	8	]	]	-RRB-
cord-030504-442pnl5s	104	9	.	.	.
cord-030504-442pnl5s	105	1	These	these	DT
cord-030504-442pnl5s	105	2	studies	study	NNS
cord-030504-442pnl5s	105	3	suggest	suggest	VBP
cord-030504-442pnl5s	105	4	that	that	IN
cord-030504-442pnl5s	105	5	there	there	EX
cord-030504-442pnl5s	105	6	is	be	VBZ
cord-030504-442pnl5s	105	7	still	still	RB
cord-030504-442pnl5s	105	8	a	a	DT
cord-030504-442pnl5s	105	9	need	need	NN
cord-030504-442pnl5s	105	10	for	for	IN
cord-030504-442pnl5s	105	11	strengthening	strengthen	VBG
cord-030504-442pnl5s	105	12	surveillance	surveillance	NN
cord-030504-442pnl5s	105	13	of	of	IN
cord-030504-442pnl5s	105	14	EV71	EV71	NNP
cord-030504-442pnl5s	105	15	genotypes	genotype	NNS
cord-030504-442pnl5s	105	16	and	and	CC
cord-030504-442pnl5s	105	17	the	the	DT
cord-030504-442pnl5s	105	18	development	development	NN
cord-030504-442pnl5s	105	19	of	of	IN
cord-030504-442pnl5s	105	20	new	new	JJ
cord-030504-442pnl5s	105	21	EV71	EV71	NNP
cord-030504-442pnl5s	105	22	vaccines	vaccine	NNS
cord-030504-442pnl5s	105	23	.	.	.
cord-030504-442pnl5s	106	1	This	this	DT
cord-030504-442pnl5s	106	2	study	study	NN
cord-030504-442pnl5s	106	3	had	have	VBD
cord-030504-442pnl5s	106	4	a	a	DT
cord-030504-442pnl5s	106	5	retrospective	retrospective	JJ
cord-030504-442pnl5s	106	6	design	design	NN
cord-030504-442pnl5s	106	7	,	,	,
cord-030504-442pnl5s	106	8	and	and	CC
cord-030504-442pnl5s	106	9	there	there	EX
cord-030504-442pnl5s	106	10	are	be	VBP
cord-030504-442pnl5s	106	11	some	some	DT
cord-030504-442pnl5s	106	12	limitations	limitation	NNS
cord-030504-442pnl5s	106	13	.	.	.
cord-030504-442pnl5s	107	1	First	first	RB
cord-030504-442pnl5s	107	2	,	,	,
cord-030504-442pnl5s	107	3	the	the	DT
cord-030504-442pnl5s	107	4	EV71VP1	ev71vp1	NN
cord-030504-442pnl5s	107	5	gene	gene	NN
cord-030504-442pnl5s	107	6	sequences	sequence	NNS
cord-030504-442pnl5s	107	7	from	from	IN
cord-030504-442pnl5s	107	8	China	China	NNP
cord-030504-442pnl5s	107	9	analysed	analyse	VBD
cord-030504-442pnl5s	107	10	in	in	IN
cord-030504-442pnl5s	107	11	this	this	DT
cord-030504-442pnl5s	107	12	study	study	NN
cord-030504-442pnl5s	107	13	were	be	VBD
cord-030504-442pnl5s	107	14	downloaded	download	VBN
cord-030504-442pnl5s	107	15	from	from	IN
cord-030504-442pnl5s	107	16	the	the	DT
cord-030504-442pnl5s	107	17	GenBank	GenBank	NNP
cord-030504-442pnl5s	107	18	database	database	NN
cord-030504-442pnl5s	107	19	but	but	CC
cord-030504-442pnl5s	107	20	were	be	VBD
cord-030504-442pnl5s	107	21	not	not	RB
cord-030504-442pnl5s	107	22	tested	test	VBN
cord-030504-442pnl5s	107	23	by	by	IN
cord-030504-442pnl5s	107	24	us	-PRON-	PRP
cord-030504-442pnl5s	107	25	.	.	.
cord-030504-442pnl5s	108	1	Due	due	IN
cord-030504-442pnl5s	108	2	to	to	IN
cord-030504-442pnl5s	108	3	time	time	NN
cord-030504-442pnl5s	108	4	constraints	constraint	NNS
cord-030504-442pnl5s	108	5	,	,	,
cord-030504-442pnl5s	108	6	only	only	RB
cord-030504-442pnl5s	108	7	the	the	DT
cord-030504-442pnl5s	108	8	VP1	VP1	NNP
cord-030504-442pnl5s	108	9	region	region	NN
cord-030504-442pnl5s	108	10	was	be	VBD
cord-030504-442pnl5s	108	11	analysed	analyse	VBN
cord-030504-442pnl5s	108	12	and	and	CC
cord-030504-442pnl5s	108	13	studied	study	VBN
cord-030504-442pnl5s	108	14	.	.	.
cord-030504-442pnl5s	109	1	In	in	IN
cord-030504-442pnl5s	109	2	future	future	JJ
cord-030504-442pnl5s	109	3	studies	study	NNS
cord-030504-442pnl5s	109	4	,	,	,
cord-030504-442pnl5s	109	5	we	-PRON-	PRP
cord-030504-442pnl5s	109	6	will	will	MD
cord-030504-442pnl5s	109	7	conduct	conduct	VB
cord-030504-442pnl5s	109	8	research	research	NN
cord-030504-442pnl5s	109	9	on	on	IN
cord-030504-442pnl5s	109	10	the	the	DT
cord-030504-442pnl5s	109	11	complete	complete	JJ
cord-030504-442pnl5s	109	12	genome	genome	NN
cord-030504-442pnl5s	109	13	sequence	sequence	NN
cord-030504-442pnl5s	109	14	of	of	IN
cord-030504-442pnl5s	109	15	EV71	EV71	NNP
cord-030504-442pnl5s	109	16	in	in	IN
cord-030504-442pnl5s	109	17	China	China	NNP
cord-030504-442pnl5s	109	18	.	.	.
cord-030504-442pnl5s	110	1	Second	second	RB
cord-030504-442pnl5s	110	2	,	,	,
cord-030504-442pnl5s	110	3	the	the	DT
cord-030504-442pnl5s	110	4	Chinese	chinese	JJ
cord-030504-442pnl5s	110	5	EV71VP1	EV71VP1	HYPH
cord-030504-442pnl5s	110	6	strains	strain	NNS
cord-030504-442pnl5s	110	7	registered	register	VBN
cord-030504-442pnl5s	110	8	in	in	IN
cord-030504-442pnl5s	110	9	GenBank	GenBank	NNP
cord-030504-442pnl5s	110	10	do	do	VBP
cord-030504-442pnl5s	110	11	not	not	RB
cord-030504-442pnl5s	110	12	cover	cover	VB
cord-030504-442pnl5s	110	13	all	all	DT
cord-030504-442pnl5s	110	14	provinces	province	NNS
cord-030504-442pnl5s	110	15	in	in	IN
cord-030504-442pnl5s	110	16	the	the	DT
cord-030504-442pnl5s	110	17	country	country	NN
cord-030504-442pnl5s	110	18	,	,	,
cord-030504-442pnl5s	110	19	and	and	CC
cord-030504-442pnl5s	110	20	the	the	DT
cord-030504-442pnl5s	110	21	data	datum	NNS
cord-030504-442pnl5s	110	22	for	for	IN
cord-030504-442pnl5s	110	23	some	some	DT
cord-030504-442pnl5s	110	24	years	year	NNS
cord-030504-442pnl5s	110	25	are	be	VBP
cord-030504-442pnl5s	110	26	missing	miss	VBG
cord-030504-442pnl5s	110	27	;	;	:
cord-030504-442pnl5s	110	28	thus	thus	RB
cord-030504-442pnl5s	110	29	,	,	,
cord-030504-442pnl5s	110	30	some	some	DT
cord-030504-442pnl5s	110	31	isolates	isolate	NNS
cord-030504-442pnl5s	110	32	of	of	IN
cord-030504-442pnl5s	110	33	other	other	JJ
cord-030504-442pnl5s	110	34	genotypes	genotype	NNS
cord-030504-442pnl5s	110	35	may	may	MD
cord-030504-442pnl5s	110	36	have	have	VB
cord-030504-442pnl5s	110	37	been	be	VBN
cord-030504-442pnl5s	110	38	unavailable	unavailable	JJ
cord-030504-442pnl5s	110	39	.	.	.
cord-030504-442pnl5s	111	1	Third	third	RB
cord-030504-442pnl5s	111	2	,	,	,
cord-030504-442pnl5s	111	3	it	-PRON-	PRP
cord-030504-442pnl5s	111	4	is	be	VBZ
cord-030504-442pnl5s	111	5	not	not	RB
cord-030504-442pnl5s	111	6	clear	clear	JJ
cord-030504-442pnl5s	111	7	whether	whether	IN
cord-030504-442pnl5s	111	8	some	some	DT
cord-030504-442pnl5s	111	9	variations	variation	NNS
cord-030504-442pnl5s	111	10	in	in	IN
cord-030504-442pnl5s	111	11	the	the	DT
cord-030504-442pnl5s	111	12	amino	amino	NN
cord-030504-442pnl5s	111	13	acid	acid	NN
cord-030504-442pnl5s	111	14	residues	residue	NNS
cord-030504-442pnl5s	111	15	found	find	VBN
cord-030504-442pnl5s	111	16	in	in	IN
cord-030504-442pnl5s	111	17	the	the	DT
cord-030504-442pnl5s	111	18	study	study	NN
cord-030504-442pnl5s	111	19	are	be	VBP
cord-030504-442pnl5s	111	20	related	relate	VBN
cord-030504-442pnl5s	111	21	to	to	IN
cord-030504-442pnl5s	111	22	the	the	DT
cord-030504-442pnl5s	111	23	severity	severity	NN
cord-030504-442pnl5s	111	24	of	of	IN
cord-030504-442pnl5s	111	25	disease	disease	NN
cord-030504-442pnl5s	111	26	or	or	CC
cord-030504-442pnl5s	111	27	the	the	DT
cord-030504-442pnl5s	111	28	route	route	NN
cord-030504-442pnl5s	111	29	of	of	IN
cord-030504-442pnl5s	111	30	transmission	transmission	NN
cord-030504-442pnl5s	111	31	.	.	.
cord-030504-442pnl5s	112	1	In	in	IN
cord-030504-442pnl5s	112	2	summary	summary	NN
cord-030504-442pnl5s	112	3	,	,	,
cord-030504-442pnl5s	112	4	the	the	DT
cord-030504-442pnl5s	112	5	prevalent	prevalent	JJ
cord-030504-442pnl5s	112	6	strains	strain	NNS
cord-030504-442pnl5s	112	7	of	of	IN
cord-030504-442pnl5s	112	8	EV71	EV71	NNP
cord-030504-442pnl5s	112	9	belong	belong	VBP
cord-030504-442pnl5s	112	10	mainly	mainly	RB
cord-030504-442pnl5s	112	11	to	to	IN
cord-030504-442pnl5s	112	12	the	the	DT
cord-030504-442pnl5s	112	13	C4	C4	NNP
cord-030504-442pnl5s	112	14	genotype	genotype	NN
cord-030504-442pnl5s	112	15	.	.	.
cord-030504-442pnl5s	113	1	The	the	DT
cord-030504-442pnl5s	113	2	C4a	c4a	CD
cord-030504-442pnl5s	113	3	subgenotype	subgenotype	NN
cord-030504-442pnl5s	113	4	was	be	VBD
cord-030504-442pnl5s	113	5	predominant	predominant	JJ
cord-030504-442pnl5s	113	6	,	,	,
cord-030504-442pnl5s	113	7	the	the	DT
cord-030504-442pnl5s	113	8	C4b	c4b	NN
cord-030504-442pnl5s	113	9	subgenotype	subgenotype	NN
cord-030504-442pnl5s	113	10	was	be	VBD
cord-030504-442pnl5s	113	11	the	the	DT
cord-030504-442pnl5s	113	12	second	second	JJ
cord-030504-442pnl5s	113	13	most	most	RBS
cord-030504-442pnl5s	113	14	prevalent	prevalent	JJ
cord-030504-442pnl5s	113	15	,	,	,
cord-030504-442pnl5s	113	16	whereas	whereas	IN
cord-030504-442pnl5s	113	17	other	other	JJ
cord-030504-442pnl5s	113	18	subgenotypes	subgenotype	NNS
cord-030504-442pnl5s	113	19	appeared	appear	VBD
cord-030504-442pnl5s	113	20	sporadically	sporadically	RB
cord-030504-442pnl5s	113	21	in	in	IN
cord-030504-442pnl5s	113	22	mainland	mainland	NN
cord-030504-442pnl5s	113	23	China	China	NNP
cord-030504-442pnl5s	113	24	.	.	.
cord-030504-442pnl5s	114	1	The	the	DT
cord-030504-442pnl5s	114	2	B4	B4	NNP
cord-030504-442pnl5s	114	3	genotype	genotype	NN
cord-030504-442pnl5s	114	4	was	be	VBD
cord-030504-442pnl5s	114	5	the	the	DT
cord-030504-442pnl5s	114	6	dominant	dominant	JJ
cord-030504-442pnl5s	114	7	genotype	genotype	NN
cord-030504-442pnl5s	114	8	in	in	IN
cord-030504-442pnl5s	114	9	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	114	10	,	,	,
cord-030504-442pnl5s	114	11	and	and	CC
cord-030504-442pnl5s	114	12	the	the	DT
cord-030504-442pnl5s	114	13	epidemic	epidemic	NN
cord-030504-442pnl5s	114	14	strain	strain	NN
cord-030504-442pnl5s	114	15	is	be	VBZ
cord-030504-442pnl5s	114	16	continuously	continuously	RB
cord-030504-442pnl5s	114	17	changing	change	VBG
cord-030504-442pnl5s	114	18	.	.	.
cord-030504-442pnl5s	115	1	Moreover	moreover	RB
cord-030504-442pnl5s	115	2	,	,	,
cord-030504-442pnl5s	115	3	variation	variation	NN
cord-030504-442pnl5s	115	4	in	in	IN
cord-030504-442pnl5s	115	5	key	key	JJ
cord-030504-442pnl5s	115	6	positions	position	NNS
cord-030504-442pnl5s	115	7	of	of	IN
cord-030504-442pnl5s	115	8	the	the	DT
cord-030504-442pnl5s	115	9	EV71VP1	ev71vp1	NN
cord-030504-442pnl5s	115	10	region	region	NN
cord-030504-442pnl5s	115	11	is	be	VBZ
cord-030504-442pnl5s	115	12	very	very	RB
cord-030504-442pnl5s	115	13	important	important	JJ
cord-030504-442pnl5s	115	14	for	for	IN
cord-030504-442pnl5s	115	15	the	the	DT
cord-030504-442pnl5s	115	16	development	development	NN
cord-030504-442pnl5s	115	17	of	of	IN
cord-030504-442pnl5s	115	18	severe	severe	JJ
cord-030504-442pnl5s	115	19	HFMD	HFMD	NNP
cord-030504-442pnl5s	115	20	.	.	.
cord-030504-442pnl5s	116	1	Taken	take	VBN
cord-030504-442pnl5s	116	2	together	together	RB
cord-030504-442pnl5s	116	3	,	,	,
cord-030504-442pnl5s	116	4	the	the	DT
cord-030504-442pnl5s	116	5	findings	finding	NNS
cord-030504-442pnl5s	116	6	indicate	indicate	VBP
cord-030504-442pnl5s	116	7	that	that	IN
cord-030504-442pnl5s	116	8	the	the	DT
cord-030504-442pnl5s	116	9	genetic	genetic	JJ
cord-030504-442pnl5s	116	10	characteristics	characteristic	NNS
cord-030504-442pnl5s	116	11	of	of	IN
cord-030504-442pnl5s	116	12	the	the	DT
cord-030504-442pnl5s	116	13	EV71VP1	ev71vp1	NN
cord-030504-442pnl5s	116	14	region	region	NN
cord-030504-442pnl5s	116	15	should	should	MD
cord-030504-442pnl5s	116	16	be	be	VB
cord-030504-442pnl5s	116	17	continuously	continuously	RB
cord-030504-442pnl5s	116	18	monitored	monitor	VBN
cord-030504-442pnl5s	116	19	,	,	,
cord-030504-442pnl5s	116	20	which	which	WDT
cord-030504-442pnl5s	116	21	is	be	VBZ
cord-030504-442pnl5s	116	22	essential	essential	JJ
cord-030504-442pnl5s	116	23	for	for	IN
cord-030504-442pnl5s	116	24	the	the	DT
cord-030504-442pnl5s	116	25	prevention	prevention	NN
cord-030504-442pnl5s	116	26	and	and	CC
cord-030504-442pnl5s	116	27	control	control	NN
cord-030504-442pnl5s	116	28	of	of	IN
cord-030504-442pnl5s	116	29	EV71-associated	EV71-associated	NNP
cord-030504-442pnl5s	116	30	HFMD	HFMD	NNP
cord-030504-442pnl5s	116	31	in	in	IN
cord-030504-442pnl5s	116	32	children	child	NNS
cord-030504-442pnl5s	116	33	and	and	CC
cord-030504-442pnl5s	116	34	EV71	EV71	NNP
cord-030504-442pnl5s	116	35	vaccine	vaccine	NN
cord-030504-442pnl5s	116	36	design	design	NN
cord-030504-442pnl5s	116	37	.	.	.
cord-030504-442pnl5s	117	1	Enterovirus	enterovirus	NN
cord-030504-442pnl5s	117	2	71	71	CD
cord-030504-442pnl5s	117	3	outbreak	outbreak	NN
cord-030504-442pnl5s	117	4	in	in	IN
cord-030504-442pnl5s	117	5	the	the	DT
cord-030504-442pnl5s	117	6	People	People	NNPS
cord-030504-442pnl5s	117	7	's	's	POS
cord-030504-442pnl5s	117	8	Republic	Republic	NNP
cord-030504-442pnl5s	117	9	of	of	IN
cord-030504-442pnl5s	117	10	China	China	NNP
cord-030504-442pnl5s	117	11	in	in	IN
cord-030504-442pnl5s	117	12	2008	2008	CD
cord-030504-442pnl5s	117	13	Hand	Hand	NNP
cord-030504-442pnl5s	117	14	,	,	,
cord-030504-442pnl5s	117	15	foot	foot	NN
cord-030504-442pnl5s	117	16	,	,	,
cord-030504-442pnl5s	117	17	and	and	CC
cord-030504-442pnl5s	117	18	mouth	mouth	NN
cord-030504-442pnl5s	117	19	disease	disease	NN
cord-030504-442pnl5s	117	20	in	in	IN
cord-030504-442pnl5s	117	21	China	China	NNP
cord-030504-442pnl5s	117	22	:	:	:
cord-030504-442pnl5s	118	1	patterns	pattern	NNS
cord-030504-442pnl5s	118	2	of	of	IN
cord-030504-442pnl5s	118	3	spread	spread	NN
cord-030504-442pnl5s	118	4	and	and	CC
cord-030504-442pnl5s	118	5	transmissibility	transmissibility	NN
cord-030504-442pnl5s	118	6	Hand	hand	NN
cord-030504-442pnl5s	118	7	,	,	,
cord-030504-442pnl5s	118	8	foot	foot	NN
cord-030504-442pnl5s	118	9	,	,	,
cord-030504-442pnl5s	118	10	and	and	CC
cord-030504-442pnl5s	118	11	mouth	mouth	NN
cord-030504-442pnl5s	118	12	disease	disease	NN
cord-030504-442pnl5s	118	13	in	in	IN
cord-030504-442pnl5s	118	14	China	China	NNP
cord-030504-442pnl5s	118	15	,	,	,
cord-030504-442pnl5s	118	16	2008	2008	CD
cord-030504-442pnl5s	118	17	-	-	SYM
cord-030504-442pnl5s	118	18	12	12	CD
cord-030504-442pnl5s	118	19	:	:	:
cord-030504-442pnl5s	118	20	an	an	DT
cord-030504-442pnl5s	118	21	epidemiological	epidemiological	JJ
cord-030504-442pnl5s	118	22	study	study	NN
cord-030504-442pnl5s	118	23	Virology	Virology	NNP
cord-030504-442pnl5s	118	24	,	,	,
cord-030504-442pnl5s	118	25	epidemiology	epidemiology	NN
cord-030504-442pnl5s	118	26	,	,	,
cord-030504-442pnl5s	118	27	pathogenesis	pathogenesis	NN
cord-030504-442pnl5s	118	28	,	,	,
cord-030504-442pnl5s	118	29	and	and	CC
cord-030504-442pnl5s	118	30	control	control	NN
cord-030504-442pnl5s	118	31	of	of	IN
cord-030504-442pnl5s	118	32	enterovirus	enterovirus	NN
cord-030504-442pnl5s	118	33	71	71	CD
cord-030504-442pnl5s	118	34	EV71	EV71	NNP
cord-030504-442pnl5s	118	35	infection	infection	NN
cord-030504-442pnl5s	118	36	induces	induce	VBZ
cord-030504-442pnl5s	118	37	neurodegeneration	neurodegeneration	NN
cord-030504-442pnl5s	118	38	via	via	IN
cord-030504-442pnl5s	118	39	activating	activate	VBG
cord-030504-442pnl5s	118	40	TLR7	TLR7	NNP
cord-030504-442pnl5s	118	41	signaling	signal	VBG
cord-030504-442pnl5s	118	42	and	and	CC
cord-030504-442pnl5s	118	43	IL-6	IL-6	NNP
cord-030504-442pnl5s	118	44	production	production	NN
cord-030504-442pnl5s	118	45	Severe	severe	JJ
cord-030504-442pnl5s	118	46	paediatric	paediatric	JJ
cord-030504-442pnl5s	118	47	conditions	condition	NNS
cord-030504-442pnl5s	118	48	linked	link	VBN
cord-030504-442pnl5s	118	49	with	with	IN
cord-030504-442pnl5s	118	50	EV	EV	NNP
cord-030504-442pnl5s	118	51	-	-	HYPH
cord-030504-442pnl5s	118	52	A71	A71	NNP
cord-030504-442pnl5s	118	53	and	and	CC
cord-030504-442pnl5s	118	54	EV	EV	NNP
cord-030504-442pnl5s	118	55	-	-	HYPH
cord-030504-442pnl5s	118	56	D68	D68	NNP
cord-030504-442pnl5s	119	1	,	,	,
cord-030504-442pnl5s	119	2	France	France	NNP
cord-030504-442pnl5s	119	3	Clinical	Clinical	NNP
cord-030504-442pnl5s	119	4	features	feature	NNS
cord-030504-442pnl5s	119	5	,	,	,
cord-030504-442pnl5s	119	6	diagnosis	diagnosis	NN
cord-030504-442pnl5s	119	7	,	,	,
cord-030504-442pnl5s	119	8	and	and	CC
cord-030504-442pnl5s	119	9	management	management	NN
cord-030504-442pnl5s	119	10	of	of	IN
cord-030504-442pnl5s	119	11	enterovirus	enterovirus	NN
cord-030504-442pnl5s	119	12	71	71	CD
cord-030504-442pnl5s	119	13	Therapeutic	therapeutic	JJ
cord-030504-442pnl5s	119	14	and	and	CC
cord-030504-442pnl5s	119	15	prevention	prevention	NN
cord-030504-442pnl5s	119	16	strategies	strategy	NNS
cord-030504-442pnl5s	119	17	against	against	IN
cord-030504-442pnl5s	119	18	human	human	JJ
cord-030504-442pnl5s	119	19	enterovirus	enterovirus	NN
cord-030504-442pnl5s	119	20	71	71	CD
cord-030504-442pnl5s	119	21	infection	infection	NN
cord-030504-442pnl5s	120	1	An	an	DT
cord-030504-442pnl5s	120	2	epidemic	epidemic	NN
cord-030504-442pnl5s	120	3	of	of	IN
cord-030504-442pnl5s	120	4	enterovirus	enterovirus	NN
cord-030504-442pnl5s	120	5	71	71	CD
cord-030504-442pnl5s	120	6	infection	infection	NN
cord-030504-442pnl5s	120	7	in	in	IN
cord-030504-442pnl5s	120	8	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	120	9	.	.	.
cord-030504-442pnl5s	121	1	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	121	2	Enterovirus	Enterovirus	NNP
cord-030504-442pnl5s	121	3	Epidemic	Epidemic	NNP
cord-030504-442pnl5s	121	4	Working	Working	NNP
cord-030504-442pnl5s	121	5	Group	Group	NNP
cord-030504-442pnl5s	121	6	Genetic	Genetic	NNP
cord-030504-442pnl5s	121	7	analysis	analysis	NN
cord-030504-442pnl5s	121	8	of	of	IN
cord-030504-442pnl5s	121	9	enterovirus	enterovirus	NN
cord-030504-442pnl5s	121	10	71	71	CD
cord-030504-442pnl5s	121	11	isolated	isolate	VBN
cord-030504-442pnl5s	121	12	from	from	IN
cord-030504-442pnl5s	121	13	fatal	fatal	JJ
cord-030504-442pnl5s	121	14	and	and	CC
cord-030504-442pnl5s	121	15	non	non	JJ
cord-030504-442pnl5s	121	16	-	-	JJ
cord-030504-442pnl5s	121	17	fatal	fatal	JJ
cord-030504-442pnl5s	121	18	cases	case	NNS
cord-030504-442pnl5s	121	19	of	of	IN
cord-030504-442pnl5s	121	20	hand	hand	NN
cord-030504-442pnl5s	121	21	,	,	,
cord-030504-442pnl5s	121	22	foot	foot	NN
cord-030504-442pnl5s	121	23	and	and	CC
cord-030504-442pnl5s	121	24	mouth	mouth	NN
cord-030504-442pnl5s	121	25	disease	disease	NN
cord-030504-442pnl5s	121	26	during	during	IN
cord-030504-442pnl5s	121	27	an	an	DT
cord-030504-442pnl5s	121	28	epidemic	epidemic	NN
cord-030504-442pnl5s	121	29	in	in	IN
cord-030504-442pnl5s	121	30	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	121	31	Epidemic	Epidemic	NNP
cord-030504-442pnl5s	121	32	hand	hand	NN
cord-030504-442pnl5s	121	33	,	,	,
cord-030504-442pnl5s	121	34	foot	foot	NN
cord-030504-442pnl5s	121	35	and	and	CC
cord-030504-442pnl5s	121	36	mouth	mouth	NN
cord-030504-442pnl5s	121	37	disease	disease	NN
cord-030504-442pnl5s	121	38	caused	cause	VBN
cord-030504-442pnl5s	121	39	by	by	IN
cord-030504-442pnl5s	121	40	human	human	JJ
cord-030504-442pnl5s	121	41	enterovirus	enterovirus	NN
cord-030504-442pnl5s	121	42	71	71	CD
cord-030504-442pnl5s	121	43	Molecular	molecular	JJ
cord-030504-442pnl5s	121	44	epidemiology	epidemiology	NN
cord-030504-442pnl5s	121	45	of	of	IN
cord-030504-442pnl5s	121	46	enterovirus	enterovirus	NN
cord-030504-442pnl5s	121	47	71	71	CD
cord-030504-442pnl5s	121	48	in	in	IN
cord-030504-442pnl5s	121	49	peninsular	peninsular	JJ
cord-030504-442pnl5s	121	50	Malaysia	Malaysia	NNP
cord-030504-442pnl5s	121	51	Population	Population	NNP
cord-030504-442pnl5s	121	52	dynamics	dynamic	NNS
cord-030504-442pnl5s	121	53	and	and	CC
cord-030504-442pnl5s	121	54	genetic	genetic	JJ
cord-030504-442pnl5s	121	55	diversity	diversity	NN
cord-030504-442pnl5s	121	56	of	of	IN
cord-030504-442pnl5s	121	57	C4	c4	NN
cord-030504-442pnl5s	121	58	strains	strain	NNS
cord-030504-442pnl5s	121	59	of	of	IN
cord-030504-442pnl5s	121	60	human	human	JJ
cord-030504-442pnl5s	121	61	enterovirus	enterovirus	NN
cord-030504-442pnl5s	121	62	71	71	CD
cord-030504-442pnl5s	121	63	in	in	IN
cord-030504-442pnl5s	121	64	Mainland	Mainland	NNP
cord-030504-442pnl5s	121	65	China	China	NNP
cord-030504-442pnl5s	121	66	Retrospective	Retrospective	NNP
cord-030504-442pnl5s	121	67	seroepidemiology	seroepidemiology	NN
cord-030504-442pnl5s	121	68	indicated	indicate	VBD
cord-030504-442pnl5s	121	69	that	that	IN
cord-030504-442pnl5s	121	70	human	human	JJ
cord-030504-442pnl5s	121	71	enterovirus	enterovirus	NN
cord-030504-442pnl5s	121	72	71	71	CD
cord-030504-442pnl5s	121	73	and	and	CC
cord-030504-442pnl5s	121	74	coxsackievirus	coxsackievirus	NNP
cord-030504-442pnl5s	121	75	A16	A16	NNP
cord-030504-442pnl5s	121	76	circulated	circulate	VBD
cord-030504-442pnl5s	121	77	wildly	wildly	RB
cord-030504-442pnl5s	121	78	in	in	IN
cord-030504-442pnl5s	121	79	central	central	JJ
cord-030504-442pnl5s	121	80	and	and	CC
cord-030504-442pnl5s	121	81	southern	southern	JJ
cord-030504-442pnl5s	121	82	China	China	NNP
cord-030504-442pnl5s	121	83	before	before	IN
cord-030504-442pnl5s	121	84	large	large	JJ
cord-030504-442pnl5s	121	85	-	-	HYPH
cord-030504-442pnl5s	121	86	scale	scale	NN
cord-030504-442pnl5s	121	87	outbreaks	outbreak	NNS
cord-030504-442pnl5s	121	88	from	from	IN
cord-030504-442pnl5s	121	89	Change	change	NN
cord-030504-442pnl5s	121	90	of	of	IN
cord-030504-442pnl5s	121	91	major	major	JJ
cord-030504-442pnl5s	121	92	genotype	genotype	NN
cord-030504-442pnl5s	121	93	of	of	IN
cord-030504-442pnl5s	121	94	enterovirus	enterovirus	NN
cord-030504-442pnl5s	121	95	71	71	CD
cord-030504-442pnl5s	121	96	in	in	IN
cord-030504-442pnl5s	121	97	outbreaks	outbreak	NNS
cord-030504-442pnl5s	121	98	of	of	IN
cord-030504-442pnl5s	121	99	hand	hand	NN
cord-030504-442pnl5s	121	100	-	-	HYPH
cord-030504-442pnl5s	121	101	foot	foot	NN
cord-030504-442pnl5s	121	102	-	-	HYPH
cord-030504-442pnl5s	121	103	and	and	CC
cord-030504-442pnl5s	121	104	-	-	HYPH
cord-030504-442pnl5s	121	105	mouth	mouth	NN
cord-030504-442pnl5s	121	106	disease	disease	NN
cord-030504-442pnl5s	121	107	in	in	IN
cord-030504-442pnl5s	121	108	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	121	109	between	between	IN
cord-030504-442pnl5s	121	110	1998	1998	CD
cord-030504-442pnl5s	121	111	and	and	CC
cord-030504-442pnl5s	121	112	Genetic	genetic	JJ
cord-030504-442pnl5s	121	113	analysis	analysis	NN
cord-030504-442pnl5s	121	114	of	of	IN
cord-030504-442pnl5s	121	115	the	the	DT
cord-030504-442pnl5s	121	116	VP1	VP1	NNP
cord-030504-442pnl5s	121	117	region	region	NN
cord-030504-442pnl5s	121	118	of	of	IN
cord-030504-442pnl5s	121	119	enterovirus	enterovirus	NN
cord-030504-442pnl5s	121	120	71	71	CD
cord-030504-442pnl5s	121	121	reveals	reveal	VBZ
cord-030504-442pnl5s	121	122	the	the	DT
cord-030504-442pnl5s	121	123	emergence	emergence	NN
cord-030504-442pnl5s	121	124	of	of	IN
cord-030504-442pnl5s	121	125	genotype	genotype	NN
cord-030504-442pnl5s	121	126	A	a	NN
cord-030504-442pnl5s	121	127	in	in	IN
cord-030504-442pnl5s	121	128	central	central	JJ
cord-030504-442pnl5s	121	129	China	China	NNP
cord-030504-442pnl5s	121	130	Evolutionary	Evolutionary	NNP
cord-030504-442pnl5s	121	131	trajectory	trajectory	NN
cord-030504-442pnl5s	121	132	of	of	IN
cord-030504-442pnl5s	121	133	the	the	DT
cord-030504-442pnl5s	121	134	VP1	VP1	NNP
cord-030504-442pnl5s	121	135	gene	gene	NN
cord-030504-442pnl5s	121	136	of	of	IN
cord-030504-442pnl5s	121	137	human	human	JJ
cord-030504-442pnl5s	121	138	enterovirus	enterovirus	NN
cord-030504-442pnl5s	121	139	71	71	CD
cord-030504-442pnl5s	121	140	genogroup	genogroup	NN
cord-030504-442pnl5s	121	141	B	B	NNP
cord-030504-442pnl5s	121	142	and	and	CC
cord-030504-442pnl5s	121	143	C	c	NN
cord-030504-442pnl5s	121	144	viruses	virus	NNS
cord-030504-442pnl5s	122	1	An	an	DT
cord-030504-442pnl5s	122	2	emerging	emerge	VBG
cord-030504-442pnl5s	122	3	recombinant	recombinant	JJ
cord-030504-442pnl5s	122	4	human	human	JJ
cord-030504-442pnl5s	122	5	enterovirus	enterovirus	NN
cord-030504-442pnl5s	122	6	71	71	CD
cord-030504-442pnl5s	122	7	responsible	responsible	JJ
cord-030504-442pnl5s	122	8	for	for	IN
cord-030504-442pnl5s	122	9	the	the	DT
cord-030504-442pnl5s	122	10	2008	2008	CD
cord-030504-442pnl5s	122	11	outbreak	outbreak	NN
cord-030504-442pnl5s	122	12	of	of	IN
cord-030504-442pnl5s	122	13	hand	hand	NN
cord-030504-442pnl5s	122	14	foot	foot	NN
cord-030504-442pnl5s	122	15	and	and	CC
cord-030504-442pnl5s	122	16	mouth	mouth	NN
cord-030504-442pnl5s	122	17	disease	disease	NN
cord-030504-442pnl5s	122	18	in	in	IN
cord-030504-442pnl5s	122	19	Fuyang	Fuyang	NNP
cord-030504-442pnl5s	122	20	city	city	NN
cord-030504-442pnl5s	122	21	of	of	IN
cord-030504-442pnl5s	122	22	China	China	NNP
cord-030504-442pnl5s	122	23	Enterovirus	Enterovirus	NNP
cord-030504-442pnl5s	122	24	71	71	CD
cord-030504-442pnl5s	122	25	infection	infection	NN
cord-030504-442pnl5s	122	26	and	and	CC
cord-030504-442pnl5s	122	27	neurological	neurological	JJ
cord-030504-442pnl5s	122	28	complications	complication	NNS
cord-030504-442pnl5s	123	1	The	the	DT
cord-030504-442pnl5s	123	2	persistent	persistent	JJ
cord-030504-442pnl5s	123	3	circulation	circulation	NN
cord-030504-442pnl5s	123	4	of	of	IN
cord-030504-442pnl5s	123	5	enterovirus	enterovirus	NN
cord-030504-442pnl5s	123	6	71	71	CD
cord-030504-442pnl5s	123	7	in	in	IN
cord-030504-442pnl5s	123	8	People	People	NNPS
cord-030504-442pnl5s	123	9	's	's	POS
cord-030504-442pnl5s	123	10	Republic	Republic	NNP
cord-030504-442pnl5s	123	11	of	of	IN
cord-030504-442pnl5s	123	12	China	China	NNP
cord-030504-442pnl5s	123	13	:	:	:
cord-030504-442pnl5s	123	14	causing	cause	VBG
cord-030504-442pnl5s	123	15	emerging	emerge	VBG
cord-030504-442pnl5s	123	16	nationwide	nationwide	JJ
cord-030504-442pnl5s	123	17	epidemics	epidemic	NNS
cord-030504-442pnl5s	123	18	since	since	IN
cord-030504-442pnl5s	123	19	Identification	identification	NN
cord-030504-442pnl5s	123	20	of	of	IN
cord-030504-442pnl5s	123	21	a	a	DT
cord-030504-442pnl5s	123	22	C2	C2	NNP
cord-030504-442pnl5s	123	23	subgenogroup	subgenogroup	NN
cord-030504-442pnl5s	123	24	strain	strain	NN
cord-030504-442pnl5s	123	25	of	of	IN
cord-030504-442pnl5s	123	26	enterovirus	enterovirus	NN
cord-030504-442pnl5s	123	27	71	71	CD
cord-030504-442pnl5s	123	28	in	in	IN
cord-030504-442pnl5s	123	29	a	a	DT
cord-030504-442pnl5s	123	30	retrospective	retrospective	JJ
cord-030504-442pnl5s	123	31	study	study	NN
cord-030504-442pnl5s	123	32	in	in	IN
cord-030504-442pnl5s	123	33	Shandong	Shandong	NNP
cord-030504-442pnl5s	123	34	Province	Province	NNP
cord-030504-442pnl5s	123	35	,	,	,
cord-030504-442pnl5s	123	36	China	China	NNP
cord-030504-442pnl5s	123	37	,	,	,
cord-030504-442pnl5s	123	38	from	from	IN
cord-030504-442pnl5s	123	39	1990	1990	CD
cord-030504-442pnl5s	123	40	to	to	IN
cord-030504-442pnl5s	123	41	2010	2010	CD
cord-030504-442pnl5s	123	42	Molecular	molecular	JJ
cord-030504-442pnl5s	123	43	epidemiology	epidemiology	NN
cord-030504-442pnl5s	123	44	of	of	IN
cord-030504-442pnl5s	123	45	human	human	JJ
cord-030504-442pnl5s	123	46	enterovirus	enterovirus	NN
cord-030504-442pnl5s	123	47	associated	associate	VBN
cord-030504-442pnl5s	123	48	with	with	IN
cord-030504-442pnl5s	123	49	aseptic	aseptic	JJ
cord-030504-442pnl5s	123	50	meningitis	meningitis	NN
cord-030504-442pnl5s	123	51	in	in	IN
cord-030504-442pnl5s	123	52	Human	human	JJ
cord-030504-442pnl5s	123	53	enterovirus	enterovirus	NN
cord-030504-442pnl5s	123	54	71	71	CD
cord-030504-442pnl5s	123	55	epidemics	epidemic	NNS
cord-030504-442pnl5s	124	1	:	:	:
cord-030504-442pnl5s	124	2	what	what	WP
cord-030504-442pnl5s	124	3	's	be	VBZ
cord-030504-442pnl5s	124	4	next	next	JJ
cord-030504-442pnl5s	124	5	?	?	.
cord-030504-442pnl5s	125	1	Epidemiology	epidemiology	NN
cord-030504-442pnl5s	125	2	of	of	IN
cord-030504-442pnl5s	125	3	enterovirus	enterovirus	NN
cord-030504-442pnl5s	125	4	71	71	CD
cord-030504-442pnl5s	125	5	infections	infection	NNS
cord-030504-442pnl5s	125	6	in	in	IN
cord-030504-442pnl5s	125	7	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	125	8	Mutations	Mutations	NNPS
cord-030504-442pnl5s	125	9	in	in	IN
cord-030504-442pnl5s	125	10	the	the	DT
cord-030504-442pnl5s	125	11	non	non	JJ
cord-030504-442pnl5s	125	12	-	-	JJ
cord-030504-442pnl5s	125	13	structural	structural	JJ
cord-030504-442pnl5s	125	14	protein	protein	NN
cord-030504-442pnl5s	125	15	region	region	NN
cord-030504-442pnl5s	125	16	contribute	contribute	VBP
cord-030504-442pnl5s	125	17	to	to	IN
cord-030504-442pnl5s	125	18	intra	intra	JJ
cord-030504-442pnl5s	125	19	-	-	JJ
cord-030504-442pnl5s	125	20	genotypic	genotypic	JJ
cord-030504-442pnl5s	125	21	evolution	evolution	NN
cord-030504-442pnl5s	125	22	of	of	IN
cord-030504-442pnl5s	125	23	enterovirus	enterovirus	NN
cord-030504-442pnl5s	125	24	71	71	CD
cord-030504-442pnl5s	125	25	Review	Review	NNP
cord-030504-442pnl5s	125	26	of	of	IN
cord-030504-442pnl5s	125	27	enterovirus	enterovirus	NN
cord-030504-442pnl5s	125	28	71	71	CD
cord-030504-442pnl5s	125	29	vaccines	vaccine	NNS
cord-030504-442pnl5s	125	30	):	):	XX
cord-030504-442pnl5s	126	1	e79783	e79783	NNP
cord-030504-442pnl5s	126	2	.	.	.
cord-030504-442pnl5s	127	1	•	•	NNP
cord-030504-442pnl5s	127	2	fast	fast	RB
cord-030504-442pnl5s	127	3	,	,	,
cord-030504-442pnl5s	127	4	convenient	convenient	JJ
cord-030504-442pnl5s	127	5	online	online	JJ
cord-030504-442pnl5s	127	6	submission	submission	NN
cord-030504-442pnl5s	127	7	•	•	NN
cord-030504-442pnl5s	128	1	thorough	thorough	JJ
cord-030504-442pnl5s	128	2	peer	peer	NN
cord-030504-442pnl5s	128	3	review	review	NN
cord-030504-442pnl5s	128	4	by	by	IN
cord-030504-442pnl5s	128	5	experienced	experienced	JJ
cord-030504-442pnl5s	128	6	researchers	researcher	NNS
cord-030504-442pnl5s	128	7	in	in	IN
cord-030504-442pnl5s	128	8	your	-PRON-	PRP$
cord-030504-442pnl5s	128	9	field	field	NN
cord-030504-442pnl5s	129	1	•	•	NNP
cord-030504-442pnl5s	129	2	rapid	rapid	JJ
cord-030504-442pnl5s	129	3	publication	publication	NN
cord-030504-442pnl5s	129	4	on	on	IN
cord-030504-442pnl5s	129	5	acceptance	acceptance	NN
cord-030504-442pnl5s	130	1	•	•	NNP
cord-030504-442pnl5s	130	2	support	support	NN
cord-030504-442pnl5s	130	3	for	for	IN
cord-030504-442pnl5s	130	4	research	research	NN
cord-030504-442pnl5s	130	5	data	datum	NNS
cord-030504-442pnl5s	130	6	,	,	,
cord-030504-442pnl5s	130	7	including	include	VBG
cord-030504-442pnl5s	131	1	large	large	JJ
cord-030504-442pnl5s	131	2	and	and	CC
cord-030504-442pnl5s	131	3	complex	complex	JJ
cord-030504-442pnl5s	131	4	data	data	NN
cord-030504-442pnl5s	131	5	types	type	NNS
cord-030504-442pnl5s	131	6	•	•	NNP
cord-030504-442pnl5s	132	1	gold	gold	NNP
cord-030504-442pnl5s	132	2	Open	Open	NNP
cord-030504-442pnl5s	132	3	Access	Access	NNP
cord-030504-442pnl5s	132	4	which	which	WDT
cord-030504-442pnl5s	132	5	fosters	foster	VBZ
cord-030504-442pnl5s	132	6	wider	wide	JJR
cord-030504-442pnl5s	132	7	collaboration	collaboration	NN
cord-030504-442pnl5s	132	8	and	and	CC
cord-030504-442pnl5s	132	9	increased	increase	VBN
cord-030504-442pnl5s	132	10	citations	citation	NNS
cord-030504-442pnl5s	132	11	maximum	maximum	JJ
cord-030504-442pnl5s	132	12	visibility	visibility	NN
cord-030504-442pnl5s	132	13	for	for	IN
cord-030504-442pnl5s	132	14	your	-PRON-	PRP$
cord-030504-442pnl5s	132	15	research	research	NN
cord-030504-442pnl5s	132	16	:	:	:
cord-030504-442pnl5s	132	17	over	over	IN
cord-030504-442pnl5s	132	18	100	100	CD
cord-030504-442pnl5s	132	19	M	M	NNP
cord-030504-442pnl5s	132	20	website	website	NN
cord-030504-442pnl5s	132	21	views	view	NNS
cord-030504-442pnl5s	132	22	per	per	IN
cord-030504-442pnl5s	132	23	year	year	NN
cord-030504-442pnl5s	133	1	•	•	NNP
cord-030504-442pnl5s	134	1	At	at	IN
cord-030504-442pnl5s	134	2	BMC	BMC	NNP
cord-030504-442pnl5s	134	3	Molecular	Molecular	NNP
cord-030504-442pnl5s	134	4	epidemiology	epidemiology	NN
cord-030504-442pnl5s	134	5	of	of	IN
cord-030504-442pnl5s	134	6	human	human	JJ
cord-030504-442pnl5s	134	7	enterovirus	enterovirus	NN
cord-030504-442pnl5s	134	8	71	71	CD
cord-030504-442pnl5s	134	9	in	in	IN
cord-030504-442pnl5s	134	10	the	the	DT
cord-030504-442pnl5s	134	11	United	United	NNP
cord-030504-442pnl5s	134	12	Kingdom	Kingdom	NNP
cord-030504-442pnl5s	134	13	from	from	IN
cord-030504-442pnl5s	134	14	1998	1998	CD
cord-030504-442pnl5s	134	15	to	to	IN
cord-030504-442pnl5s	134	16	Appearance	Appearance	NNP
cord-030504-442pnl5s	134	17	of	of	IN
cord-030504-442pnl5s	134	18	intratypic	intratypic	JJ
cord-030504-442pnl5s	134	19	recombination	recombination	NN
cord-030504-442pnl5s	134	20	of	of	IN
cord-030504-442pnl5s	134	21	enterovirus	enterovirus	NN
cord-030504-442pnl5s	134	22	71	71	CD
cord-030504-442pnl5s	134	23	in	in	IN
cord-030504-442pnl5s	134	24	Taiwan	Taiwan	NNP
cord-030504-442pnl5s	134	25	from	from	IN
cord-030504-442pnl5s	134	26	Detection	detection	NN
cord-030504-442pnl5s	134	27	of	of	IN
cord-030504-442pnl5s	134	28	recombination	recombination	NN
cord-030504-442pnl5s	134	29	breakpoints	breakpoint	NNS
cord-030504-442pnl5s	134	30	in	in	IN
cord-030504-442pnl5s	134	31	the	the	DT
cord-030504-442pnl5s	134	32	genomes	genome	NNS
cord-030504-442pnl5s	134	33	of	of	IN
cord-030504-442pnl5s	134	34	human	human	JJ
cord-030504-442pnl5s	134	35	enterovirus	enterovirus	NN
cord-030504-442pnl5s	134	36	71	71	CD
cord-030504-442pnl5s	134	37	strains	strain	NNS
cord-030504-442pnl5s	134	38	isolated	isolate	VBN
cord-030504-442pnl5s	134	39	in	in	IN
cord-030504-442pnl5s	134	40	the	the	DT
cord-030504-442pnl5s	134	41	Netherlands	Netherlands	NNP
cord-030504-442pnl5s	134	42	in	in	IN
cord-030504-442pnl5s	134	43	epidemic	epidemic	NN
cord-030504-442pnl5s	134	44	and	and	CC
cord-030504-442pnl5s	134	45	non	non	JJ
cord-030504-442pnl5s	134	46	-	-	JJ
cord-030504-442pnl5s	134	47	epidemic	epidemic	JJ
cord-030504-442pnl5s	134	48	years	year	NNS
cord-030504-442pnl5s	135	1	The	the	DT
cord-030504-442pnl5s	135	2	association	association	NN
cord-030504-442pnl5s	135	3	of	of	IN
cord-030504-442pnl5s	135	4	recombination	recombination	NN
cord-030504-442pnl5s	135	5	events	event	NNS
cord-030504-442pnl5s	135	6	in	in	IN
cord-030504-442pnl5s	135	7	the	the	DT
cord-030504-442pnl5s	135	8	founding	founding	NN
cord-030504-442pnl5s	135	9	and	and	CC
cord-030504-442pnl5s	135	10	emergence	emergence	NN
cord-030504-442pnl5s	135	11	of	of	IN
cord-030504-442pnl5s	135	12	subgenogroup	subgenogroup	NN
cord-030504-442pnl5s	135	13	evolutionary	evolutionary	JJ
cord-030504-442pnl5s	135	14	lineages	lineage	NNS
cord-030504-442pnl5s	135	15	of	of	IN
cord-030504-442pnl5s	135	16	human	human	JJ
cord-030504-442pnl5s	135	17	enterovirus	enterovirus	NN
cord-030504-442pnl5s	135	18	71	71	CD
cord-030504-442pnl5s	135	19	Complete	complete	JJ
cord-030504-442pnl5s	135	20	genome	genome	NN
cord-030504-442pnl5s	135	21	characterization	characterization	NN
cord-030504-442pnl5s	135	22	of	of	IN
cord-030504-442pnl5s	135	23	the	the	DT
cord-030504-442pnl5s	135	24	2017	2017	CD
cord-030504-442pnl5s	135	25	dengue	dengue	NN
cord-030504-442pnl5s	135	26	outbreak	outbreak	NN
cord-030504-442pnl5s	135	27	in	in	IN
cord-030504-442pnl5s	135	28	Xishuangbanna	Xishuangbanna	NNP
cord-030504-442pnl5s	135	29	,	,	,
cord-030504-442pnl5s	135	30	a	a	DT
cord-030504-442pnl5s	135	31	Border	Border	NNP
cord-030504-442pnl5s	135	32	City	City	NNP
cord-030504-442pnl5s	135	33	of	of	IN
cord-030504-442pnl5s	135	34	China	China	NNP
cord-030504-442pnl5s	135	35	Complete	Complete	NNP
cord-030504-442pnl5s	135	36	genome	genome	NN
cord-030504-442pnl5s	135	37	analysis	analysis	NN
cord-030504-442pnl5s	135	38	of	of	IN
cord-030504-442pnl5s	135	39	the	the	DT
cord-030504-442pnl5s	135	40	C4	c4	NN
cord-030504-442pnl5s	135	41	subgenotype	subgenotype	NN
cord-030504-442pnl5s	135	42	strains	strain	NNS
cord-030504-442pnl5s	135	43	of	of	IN
cord-030504-442pnl5s	135	44	enterovirus	enterovirus	NN
cord-030504-442pnl5s	135	45	71	71	CD
cord-030504-442pnl5s	135	46	:	:	:
cord-030504-442pnl5s	135	47	predominant	predominant	JJ
cord-030504-442pnl5s	135	48	recombination	recombination	NN
cord-030504-442pnl5s	135	49	C4	c4	NN
cord-030504-442pnl5s	135	50	viruses	virus	NNS
cord-030504-442pnl5s	135	51	persistently	persistently	RB
cord-030504-442pnl5s	135	52	circulating	circulate	VBG
cord-030504-442pnl5s	135	53	in	in	IN
cord-030504-442pnl5s	135	54	China	China	NNP
cord-030504-442pnl5s	135	55	for	for	IN
cord-030504-442pnl5s	135	56	14	14	CD
cord-030504-442pnl5s	135	57	years	year	NNS
cord-030504-442pnl5s	135	58	Effectiveness	Effectiveness	NNP
cord-030504-442pnl5s	135	59	of	of	IN
cord-030504-442pnl5s	135	60	EV	EV	NNP
cord-030504-442pnl5s	135	61	-	-	HYPH
cord-030504-442pnl5s	135	62	A71	A71	NNP
cord-030504-442pnl5s	135	63	vaccination	vaccination	NN
cord-030504-442pnl5s	135	64	in	in	IN
cord-030504-442pnl5s	135	65	prevention	prevention	NN
cord-030504-442pnl5s	135	66	of	of	IN
cord-030504-442pnl5s	135	67	paediatric	paediatric	JJ
cord-030504-442pnl5s	135	68	hand	hand	NN
cord-030504-442pnl5s	135	69	,	,	,
cord-030504-442pnl5s	135	70	foot	foot	NN
cord-030504-442pnl5s	135	71	,	,	,
cord-030504-442pnl5s	135	72	and	and	CC
cord-030504-442pnl5s	135	73	mouth	mouth	NN
cord-030504-442pnl5s	135	74	disease	disease	NN
cord-030504-442pnl5s	135	75	associated	associate	VBN
cord-030504-442pnl5s	135	76	with	with	IN
cord-030504-442pnl5s	135	77	EV	EV	NNP
cord-030504-442pnl5s	135	78	-	-	HYPH
cord-030504-442pnl5s	135	79	A71	A71	NNP
cord-030504-442pnl5s	135	80	virus	virus	NN
cord-030504-442pnl5s	135	81	infection	infection	NN
cord-030504-442pnl5s	135	82	requiring	require	VBG
cord-030504-442pnl5s	135	83	hospitalisation	hospitalisation	NN
cord-030504-442pnl5s	135	84	in	in	IN
cord-030504-442pnl5s	135	85	Henan	Henan	NNP
cord-030504-442pnl5s	135	86	,	,	,
cord-030504-442pnl5s	135	87	China	China	NNP
cord-030504-442pnl5s	135	88	,	,	,
cord-030504-442pnl5s	135	89	2017	2017	CD
cord-030504-442pnl5s	135	90	-	-	SYM
cord-030504-442pnl5s	135	91	18	18	CD
cord-030504-442pnl5s	135	92	:	:	:
cord-030504-442pnl5s	135	93	a	a	DT
cord-030504-442pnl5s	135	94	test	test	NN
cord-030504-442pnl5s	135	95	-	-	HYPH
cord-030504-442pnl5s	135	96	negative	negative	JJ
cord-030504-442pnl5s	135	97	case	case	NN
cord-030504-442pnl5s	135	98	-	-	HYPH
cord-030504-442pnl5s	135	99	control	control	NN
cord-030504-442pnl5s	135	100	study	study	NN
cord-030504-442pnl5s	135	101	Epidemiology	epidemiology	NN
cord-030504-442pnl5s	135	102	and	and	CC
cord-030504-442pnl5s	135	103	etiology	etiology	NN
cord-030504-442pnl5s	135	104	of	of	IN
cord-030504-442pnl5s	135	105	hand	hand	NN
cord-030504-442pnl5s	135	106	,	,	,
cord-030504-442pnl5s	135	107	foot	foot	NN
cord-030504-442pnl5s	135	108	,	,	,
cord-030504-442pnl5s	135	109	and	and	CC
cord-030504-442pnl5s	135	110	mouth	mouth	NN
cord-030504-442pnl5s	135	111	disease	disease	NN
cord-030504-442pnl5s	135	112	in	in	IN
cord-030504-442pnl5s	135	113	Fujian	Fujian	NNP
cord-030504-442pnl5s	135	114	province	province	NN
cord-030504-442pnl5s	136	1	A	a	DT
cord-030504-442pnl5s	136	2	novel	novel	JJ
cord-030504-442pnl5s	136	3	finding	finding	NN
cord-030504-442pnl5s	136	4	for	for	IN
cord-030504-442pnl5s	136	5	enterovirus	enterovirus	NN
cord-030504-442pnl5s	136	6	virulence	virulence	NN
cord-030504-442pnl5s	136	7	from	from	IN
cord-030504-442pnl5s	136	8	the	the	DT
cord-030504-442pnl5s	136	9	capsid	capsid	JJ
cord-030504-442pnl5s	136	10	protein	protein	NN
cord-030504-442pnl5s	136	11	VP1	vp1	NN
cord-030504-442pnl5s	136	12	of	of	IN
cord-030504-442pnl5s	136	13	EV71	EV71	NNP
cord-030504-442pnl5s	136	14	circulating	circulate	VBG
cord-030504-442pnl5s	136	15	in	in	IN
cord-030504-442pnl5s	136	16	mainland	mainland	NN
cord-030504-442pnl5s	136	17	China	China	NNP
cord-030504-442pnl5s	136	18	Patterns	pattern	NNS
cord-030504-442pnl5s	136	19	of	of	IN
cord-030504-442pnl5s	136	20	polymorphism	polymorphism	NN
cord-030504-442pnl5s	136	21	and	and	CC
cord-030504-442pnl5s	136	22	divergence	divergence	NN
cord-030504-442pnl5s	136	23	in	in	IN
cord-030504-442pnl5s	136	24	the	the	DT
cord-030504-442pnl5s	136	25	VP1	VP1	NNP
cord-030504-442pnl5s	136	26	gene	gene	NN
cord-030504-442pnl5s	136	27	of	of	IN
cord-030504-442pnl5s	136	28	enterovirus	enterovirus	NN
cord-030504-442pnl5s	136	29	71	71	CD
cord-030504-442pnl5s	136	30	circulating	circulate	VBG
cord-030504-442pnl5s	136	31	in	in	IN
cord-030504-442pnl5s	136	32	the	the	DT
cord-030504-442pnl5s	136	33	Asia	Asia	NNP
cord-030504-442pnl5s	136	34	-	-	HYPH
cord-030504-442pnl5s	136	35	Pacific	Pacific	NNP
cord-030504-442pnl5s	136	36	region	region	NN
cord-030504-442pnl5s	136	37	between	between	IN
cord-030504-442pnl5s	136	38	1994	1994	CD
cord-030504-442pnl5s	136	39	and	and	CC
cord-030504-442pnl5s	136	40	2013	2013	CD
cord-030504-442pnl5s	136	41	Enterovirus	Enterovirus	NNP
cord-030504-442pnl5s	136	42	A71	A71	NNP
cord-030504-442pnl5s	136	43	VP1	vp1	NN
cord-030504-442pnl5s	136	44	variation	variation	NN
cord-030504-442pnl5s	136	45	A289	A289	NNP
cord-030504-442pnl5s	136	46	T	t	NN
cord-030504-442pnl5s	137	1	decreases	decrease	VBZ
cord-030504-442pnl5s	137	2	the	the	DT
cord-030504-442pnl5s	137	3	central	central	JJ
cord-030504-442pnl5s	137	4	nervous	nervous	JJ
cord-030504-442pnl5s	137	5	system	system	NN
cord-030504-442pnl5s	137	6	infectivity	infectivity	NN
cord-030504-442pnl5s	137	7	via	via	IN
cord-030504-442pnl5s	137	8	attenuation	attenuation	NN
cord-030504-442pnl5s	137	9	of	of	IN
cord-030504-442pnl5s	137	10	interactions	interaction	NNS
cord-030504-442pnl5s	137	11	between	between	IN
cord-030504-442pnl5s	137	12	VP1	VP1	NNP
cord-030504-442pnl5s	137	13	and	and	CC
cord-030504-442pnl5s	137	14	vimentin	vimentin	NNP
cord-030504-442pnl5s	137	15	in	in	IN
cord-030504-442pnl5s	137	16	vitro	vitro	FW
cord-030504-442pnl5s	137	17	and	and	CC
cord-030504-442pnl5s	137	18	in	in	IN
cord-030504-442pnl5s	137	19	vivo	vivo	NNP
cord-030504-442pnl5s	137	20	Enterovirus	Enterovirus	NNP
cord-030504-442pnl5s	137	21	71	71	CD
cord-030504-442pnl5s	137	22	binding	binding	NN
cord-030504-442pnl5s	137	23	to	to	IN
cord-030504-442pnl5s	137	24	PSGL-1	PSGL-1	NNP
cord-030504-442pnl5s	137	25	on	on	IN
cord-030504-442pnl5s	137	26	leukocytes	leukocyte	NNS
cord-030504-442pnl5s	137	27	:	:	:
cord-030504-442pnl5s	138	1	VP1	VP1	NNP
cord-030504-442pnl5s	138	2	-	-	HYPH
cord-030504-442pnl5s	138	3	145	145	CD
cord-030504-442pnl5s	138	4	acts	act	NNS
cord-030504-442pnl5s	138	5	as	as	IN
cord-030504-442pnl5s	138	6	a	a	DT
cord-030504-442pnl5s	138	7	molecular	molecular	JJ
cord-030504-442pnl5s	138	8	switch	switch	NN
cord-030504-442pnl5s	138	9	to	to	TO
cord-030504-442pnl5s	138	10	control	control	VB
cord-030504-442pnl5s	138	11	receptor	receptor	NN
cord-030504-442pnl5s	138	12	interaction	interaction	NN
cord-030504-442pnl5s	138	13	Antiviral	antiviral	JJ
cord-030504-442pnl5s	138	14	activity	activity	NN
cord-030504-442pnl5s	138	15	of	of	IN
cord-030504-442pnl5s	138	16	pyridyl	pyridyl	NNP
cord-030504-442pnl5s	138	17	imidazolidinones	imidazolidinones	NNP
cord-030504-442pnl5s	138	18	against	against	IN
cord-030504-442pnl5s	138	19	enterovirus	enterovirus	NN
cord-030504-442pnl5s	138	20	71	71	CD
cord-030504-442pnl5s	138	21	variants	variant	NNS
cord-030504-442pnl5s	138	22	Molecular	molecular	JJ
cord-030504-442pnl5s	138	23	epidemiology	epidemiology	NN
cord-030504-442pnl5s	138	24	analysis	analysis	NN
cord-030504-442pnl5s	138	25	of	of	IN
cord-030504-442pnl5s	138	26	enterovirus	enterovirus	NN
cord-030504-442pnl5s	138	27	71	71	CD
cord-030504-442pnl5s	138	28	strains	strain	NNS
cord-030504-442pnl5s	139	1	The	the	DT
cord-030504-442pnl5s	139	2	variations	variation	NNS
cord-030504-442pnl5s	139	3	of	of	IN
cord-030504-442pnl5s	139	4	VP1	vp1	NN
cord-030504-442pnl5s	139	5	protein	protein	NN
cord-030504-442pnl5s	139	6	might	may	MD
cord-030504-442pnl5s	139	7	be	be	VB
cord-030504-442pnl5s	139	8	associated	associate	VBN
cord-030504-442pnl5s	139	9	with	with	IN
cord-030504-442pnl5s	139	10	nervous	nervous	JJ
cord-030504-442pnl5s	139	11	system	system	NN
cord-030504-442pnl5s	139	12	symptoms	symptom	NNS
cord-030504-442pnl5s	139	13	caused	cause	VBN
cord-030504-442pnl5s	139	14	by	by	IN
cord-030504-442pnl5s	139	15	enterovirus	enterovirus	NN
cord-030504-442pnl5s	139	16	71	71	CD
cord-030504-442pnl5s	139	17	infection	infection	NN
cord-030504-442pnl5s	139	18	Amino	amino	NN
cord-030504-442pnl5s	139	19	acid	acid	NN
cord-030504-442pnl5s	139	20	variation	variation	NN
cord-030504-442pnl5s	139	21	at	at	IN
cord-030504-442pnl5s	139	22	VP1	VP1	NNP
cord-030504-442pnl5s	139	23	-	-	HYPH
cord-030504-442pnl5s	139	24	145	145	CD
cord-030504-442pnl5s	139	25	of	of	IN
cord-030504-442pnl5s	139	26	Enterovirus	Enterovirus	NNP
cord-030504-442pnl5s	139	27	71	71	CD
cord-030504-442pnl5s	139	28	determines	determine	VBZ
cord-030504-442pnl5s	139	29	attachment	attachment	NN
cord-030504-442pnl5s	139	30	receptor	receptor	NN
cord-030504-442pnl5s	139	31	usage	usage	NN
cord-030504-442pnl5s	139	32	and	and	CC
cord-030504-442pnl5s	139	33	neurovirulence	neurovirulence	NN
cord-030504-442pnl5s	139	34	in	in	IN
cord-030504-442pnl5s	139	35	human	human	JJ
cord-030504-442pnl5s	139	36	scavenger	scavenger	NN
cord-030504-442pnl5s	139	37	receptor	receptor	NN
cord-030504-442pnl5s	139	38	B2	b2	NN
cord-030504-442pnl5s	139	39	transgenic	transgenic	JJ
cord-030504-442pnl5s	139	40	mice	mouse	NNS
cord-030504-442pnl5s	139	41	Cooperative	cooperative	JJ
cord-030504-442pnl5s	139	42	effect	effect	NN
cord-030504-442pnl5s	139	43	of	of	IN
cord-030504-442pnl5s	139	44	the	the	DT
cord-030504-442pnl5s	139	45	VP1	VP1	NNP
cord-030504-442pnl5s	139	46	amino	amino	NN
cord-030504-442pnl5s	139	47	acids	acid	NNS
cord-030504-442pnl5s	139	48	98E	98e	CD
cord-030504-442pnl5s	139	49	,	,	,
cord-030504-442pnl5s	139	50	145A	145a	CD
cord-030504-442pnl5s	139	51	and	and	CC
cord-030504-442pnl5s	139	52	169F	169f	CD
cord-030504-442pnl5s	139	53	in	in	IN
cord-030504-442pnl5s	139	54	the	the	DT
cord-030504-442pnl5s	139	55	productive	productive	JJ
cord-030504-442pnl5s	139	56	infection	infection	NN
cord-030504-442pnl5s	139	57	of	of	IN
cord-030504-442pnl5s	139	58	mouse	mouse	NN
cord-030504-442pnl5s	139	59	cell	cell	NN
cord-030504-442pnl5s	139	60	lines	line	NNS
cord-030504-442pnl5s	139	61	by	by	IN
cord-030504-442pnl5s	139	62	enterovirus	enterovirus	NN
cord-030504-442pnl5s	139	63	71	71	CD
cord-030504-442pnl5s	140	1	(	(	-LRB-
cord-030504-442pnl5s	140	2	BS	BS	NNP
cord-030504-442pnl5s	140	3	strain	strain	NN
cord-030504-442pnl5s	140	4	)	)	-RRB-
cord-030504-442pnl5s	141	1	A	a	DT
cord-030504-442pnl5s	141	2	novel	novel	JJ
cord-030504-442pnl5s	141	3	murine	murine	NN
cord-030504-442pnl5s	141	4	model	model	NN
cord-030504-442pnl5s	141	5	expressing	express	VBG
cord-030504-442pnl5s	141	6	a	a	DT
cord-030504-442pnl5s	141	7	chimeric	chimeric	JJ
cord-030504-442pnl5s	141	8	mSCARB2	mSCARB2	NNS
cord-030504-442pnl5s	141	9	/	/	SYM
cord-030504-442pnl5s	141	10	hSCARB2	hSCARB2	NNS
cord-030504-442pnl5s	141	11	receptor	receptor	NN
cord-030504-442pnl5s	141	12	is	be	VBZ
cord-030504-442pnl5s	141	13	highly	highly	RB
cord-030504-442pnl5s	141	14	susceptible	susceptible	JJ
cord-030504-442pnl5s	141	15	to	to	IN
cord-030504-442pnl5s	141	16	oral	oral	JJ
cord-030504-442pnl5s	141	17	infection	infection	NN
cord-030504-442pnl5s	141	18	with	with	IN
cord-030504-442pnl5s	141	19	clinical	clinical	JJ
cord-030504-442pnl5s	141	20	isolates	isolate	NNS
cord-030504-442pnl5s	141	21	of	of	IN
cord-030504-442pnl5s	141	22	Enterovirus	Enterovirus	NNP
cord-030504-442pnl5s	141	23	71	71	CD
cord-030504-442pnl5s	141	24	An	an	DT
cord-030504-442pnl5s	141	25	infectious	infectious	JJ
cord-030504-442pnl5s	141	26	clone	clone	NN
cord-030504-442pnl5s	141	27	of	of	IN
cord-030504-442pnl5s	141	28	enterovirus	enterovirus	NN
cord-030504-442pnl5s	141	29	71(EV71	71(ev71	CD
cord-030504-442pnl5s	141	30	)	)	-RRB-
cord-030504-442pnl5s	141	31	that	that	WDT
cord-030504-442pnl5s	141	32	is	be	VBZ
cord-030504-442pnl5s	141	33	capable	capable	JJ
cord-030504-442pnl5s	141	34	of	of	IN
cord-030504-442pnl5s	141	35	infecting	infect	VBG
cord-030504-442pnl5s	141	36	neonatal	neonatal	JJ
cord-030504-442pnl5s	141	37	immune	immune	JJ
cord-030504-442pnl5s	141	38	competent	competent	JJ
cord-030504-442pnl5s	141	39	mice	mouse	NNS
cord-030504-442pnl5s	141	40	without	without	IN
cord-030504-442pnl5s	141	41	adaptive	adaptive	JJ
cord-030504-442pnl5s	141	42	mutations	mutation	NNS
cord-030504-442pnl5s	141	43	Efficacy	Efficacy	NNP
cord-030504-442pnl5s	141	44	,	,	,
cord-030504-442pnl5s	141	45	safety	safety	NN
cord-030504-442pnl5s	141	46	,	,	,
cord-030504-442pnl5s	141	47	and	and	CC
cord-030504-442pnl5s	141	48	immunology	immunology	NN
cord-030504-442pnl5s	141	49	of	of	IN
cord-030504-442pnl5s	141	50	an	an	DT
cord-030504-442pnl5s	141	51	inactivated	inactivate	VBN
cord-030504-442pnl5s	141	52	alum	alum	NN
cord-030504-442pnl5s	141	53	-	-	HYPH
cord-030504-442pnl5s	141	54	adjuvant	adjuvant	JJ
cord-030504-442pnl5s	141	55	enterovirus	enterovirus	NN
cord-030504-442pnl5s	141	56	71	71	CD
cord-030504-442pnl5s	141	57	vaccine	vaccine	NN
cord-030504-442pnl5s	141	58	in	in	IN
cord-030504-442pnl5s	141	59	children	child	NNS
cord-030504-442pnl5s	141	60	in	in	IN
cord-030504-442pnl5s	141	61	China	China	NNP
cord-030504-442pnl5s	141	62	:	:	:
cord-030504-442pnl5s	141	63	a	a	DT
cord-030504-442pnl5s	141	64	multicentre	multicentre	NNP
cord-030504-442pnl5s	141	65	,	,	,
cord-030504-442pnl5s	141	66	randomised	randomised	JJ
cord-030504-442pnl5s	141	67	,	,	,
cord-030504-442pnl5s	141	68	double	double	JJ
cord-030504-442pnl5s	141	69	-	-	HYPH
cord-030504-442pnl5s	141	70	blind	blind	JJ
cord-030504-442pnl5s	141	71	,	,	,
cord-030504-442pnl5s	141	72	placebo	placebo	NN
cord-030504-442pnl5s	141	73	-	-	HYPH
cord-030504-442pnl5s	141	74	controlled	control	VBN
cord-030504-442pnl5s	141	75	,	,	,
cord-030504-442pnl5s	141	76	phase	phase	NN
cord-030504-442pnl5s	141	77	3	3	CD
cord-030504-442pnl5s	141	78	trial	trial	NN
cord-030504-442pnl5s	141	79	EV71	EV71	NNP
cord-030504-442pnl5s	141	80	vaccine	vaccine	NN
cord-030504-442pnl5s	141	81	,	,	,
cord-030504-442pnl5s	141	82	a	a	DT
cord-030504-442pnl5s	141	83	new	new	JJ
cord-030504-442pnl5s	141	84	tool	tool	NN
cord-030504-442pnl5s	141	85	to	to	TO
cord-030504-442pnl5s	141	86	control	control	VB
cord-030504-442pnl5s	141	87	outbreaks	outbreak	NNS
cord-030504-442pnl5s	141	88	of	of	IN
cord-030504-442pnl5s	141	89	hand	hand	NN
cord-030504-442pnl5s	141	90	,	,	,
cord-030504-442pnl5s	141	91	foot	foot	NN
cord-030504-442pnl5s	141	92	and	and	CC
cord-030504-442pnl5s	141	93	mouth	mouth	NN
cord-030504-442pnl5s	141	94	disease	disease	NN
cord-030504-442pnl5s	141	95	(	(	-LRB-
cord-030504-442pnl5s	141	96	HFMD	HFMD	NNP
cord-030504-442pnl5s	141	97	)	)	-RRB-
cord-030504-442pnl5s	141	98	Epidemiology	Epidemiology	NNP
cord-030504-442pnl5s	141	99	of	of	IN
cord-030504-442pnl5s	141	100	hand	hand	NN
cord-030504-442pnl5s	141	101	,	,	,
cord-030504-442pnl5s	141	102	foot	foot	NN
cord-030504-442pnl5s	141	103	and	and	CC
cord-030504-442pnl5s	141	104	mouth	mouth	NN
cord-030504-442pnl5s	141	105	disease	disease	NN
cord-030504-442pnl5s	141	106	in	in	IN
cord-030504-442pnl5s	141	107	China	China	NNP
cord-030504-442pnl5s	142	1	An	an	DT
cord-030504-442pnl5s	142	2	inactivated	inactivate	VBN
cord-030504-442pnl5s	142	3	enterovirus	enterovirus	NN
cord-030504-442pnl5s	142	4	71	71	CD
cord-030504-442pnl5s	142	5	vaccine	vaccine	NN
cord-030504-442pnl5s	142	6	in	in	IN
cord-030504-442pnl5s	142	7	healthy	healthy	JJ
cord-030504-442pnl5s	142	8	children	child	NNS
cord-030504-442pnl5s	142	9	Efficacy	Efficacy	NNP
cord-030504-442pnl5s	142	10	,	,	,
cord-030504-442pnl5s	142	11	safety	safety	NN
cord-030504-442pnl5s	142	12	,	,	,
cord-030504-442pnl5s	142	13	and	and	CC
cord-030504-442pnl5s	142	14	immunogenicity	immunogenicity	NN
cord-030504-442pnl5s	142	15	of	of	IN
cord-030504-442pnl5s	142	16	an	an	DT
cord-030504-442pnl5s	142	17	enterovirus	enterovirus	NN
cord-030504-442pnl5s	142	18	71	71	CD
cord-030504-442pnl5s	142	19	vaccine	vaccine	NN
cord-030504-442pnl5s	142	20	in	in	IN
cord-030504-442pnl5s	142	21	China	China	NNP
cord-030504-442pnl5s	142	22	Immunogenicity	Immunogenicity	NNP
cord-030504-442pnl5s	142	23	,	,	,
cord-030504-442pnl5s	142	24	safety	safety	NN
cord-030504-442pnl5s	142	25	,	,	,
cord-030504-442pnl5s	142	26	and	and	CC
cord-030504-442pnl5s	142	27	lot	lot	NN
cord-030504-442pnl5s	142	28	consistency	consistency	NN
cord-030504-442pnl5s	142	29	of	of	IN
cord-030504-442pnl5s	142	30	a	a	DT
cord-030504-442pnl5s	142	31	novel	novel	NN
cord-030504-442pnl5s	142	32	inactivated	inactivate	VBN
cord-030504-442pnl5s	142	33	enterovirus	enterovirus	NN
cord-030504-442pnl5s	142	34	71	71	CD
cord-030504-442pnl5s	142	35	vaccine	vaccine	NN
cord-030504-442pnl5s	142	36	in	in	IN
cord-030504-442pnl5s	142	37	Chinese	chinese	JJ
cord-030504-442pnl5s	142	38	children	child	NNS
cord-030504-442pnl5s	142	39	aged	age	VBN
cord-030504-442pnl5s	142	40	6	6	CD
cord-030504-442pnl5s	142	41	to	to	TO
cord-030504-442pnl5s	142	42	59	59	CD
cord-030504-442pnl5s	142	43	months	month	NNS
cord-030504-442pnl5s	143	1	Molecular	molecular	JJ
cord-030504-442pnl5s	143	2	comparison	comparison	NN
cord-030504-442pnl5s	143	3	and	and	CC
cord-030504-442pnl5s	143	4	evolutionary	evolutionary	JJ
cord-030504-442pnl5s	143	5	analyses	analysis	NNS
cord-030504-442pnl5s	143	6	of	of	IN
cord-030504-442pnl5s	143	7	VP1	vp1	NN
cord-030504-442pnl5s	143	8	nucleotide	nucleotide	JJ
cord-030504-442pnl5s	143	9	sequences	sequence	NNS
cord-030504-442pnl5s	143	10	of	of	IN
cord-030504-442pnl5s	143	11	new	new	JJ
cord-030504-442pnl5s	143	12	African	african	JJ
cord-030504-442pnl5s	143	13	human	human	JJ
cord-030504-442pnl5s	143	14	enterovirus	enterovirus	NN
cord-030504-442pnl5s	143	15	71	71	CD
cord-030504-442pnl5s	143	16	isolates	isolate	NNS
cord-030504-442pnl5s	143	17	reveal	reveal	VBP
cord-030504-442pnl5s	143	18	a	a	DT
cord-030504-442pnl5s	143	19	wide	wide	JJ
cord-030504-442pnl5s	143	20	genetic	genetic	JJ
cord-030504-442pnl5s	143	21	diversity	diversity	NN
cord-030504-442pnl5s	144	1	The	the	DT
cord-030504-442pnl5s	144	2	authors	author	NNS
cord-030504-442pnl5s	144	3	acknowledge	acknowledge	VBP
cord-030504-442pnl5s	144	4	all	all	DT
cord-030504-442pnl5s	144	5	of	of	IN
cord-030504-442pnl5s	144	6	the	the	DT
cord-030504-442pnl5s	144	7	clinical	clinical	JJ
cord-030504-442pnl5s	144	8	staff	staff	NN
cord-030504-442pnl5s	144	9	throughout	throughout	IN
cord-030504-442pnl5s	144	10	China	China	NNP
cord-030504-442pnl5s	144	11	who	who	WP
cord-030504-442pnl5s	144	12	provided	provide	VBD
cord-030504-442pnl5s	144	13	the	the	DT
cord-030504-442pnl5s	144	14	VP1	VP1	NNP
cord-030504-442pnl5s	144	15	protein	protein	NN
cord-030504-442pnl5s	144	16	-	-	HYPH
cord-030504-442pnl5s	144	17	encoding	encode	VBG
cord-030504-442pnl5s	144	18	region	region	NN
cord-030504-442pnl5s	144	19	gene	gene	NN
cord-030504-442pnl5s	144	20	sequences	sequence	NNS
cord-030504-442pnl5s	144	21	and	and	CC
cord-030504-442pnl5s	144	22	information	information	NN
cord-030504-442pnl5s	144	23	concerning	concern	VBG
cord-030504-442pnl5s	144	24	the	the	DT
cord-030504-442pnl5s	144	25	EV71	EV71	NNP
cord-030504-442pnl5s	144	26	strains	strain	NNS
cord-030504-442pnl5s	144	27	used	use	VBN
cord-030504-442pnl5s	144	28	in	in	IN
cord-030504-442pnl5s	144	29	this	this	DT
cord-030504-442pnl5s	144	30	study	study	NN
cord-030504-442pnl5s	144	31	.	.	.
cord-030504-442pnl5s	145	1	We	-PRON-	PRP
cord-030504-442pnl5s	145	2	gratefully	gratefully	RB
cord-030504-442pnl5s	145	3	acknowledge	acknowledge	VBP
cord-030504-442pnl5s	145	4	American	American	NNP
cord-030504-442pnl5s	145	5	Journal	Journal	NNP
cord-030504-442pnl5s	145	6	Experts	Experts	NNPS
cord-030504-442pnl5s	145	7	(	(	-LRB-
cord-030504-442pnl5s	145	8	AJE	AJE	NNP
cord-030504-442pnl5s	145	9	)	)	-RRB-
cord-030504-442pnl5s	146	1	(	(	-LRB-
cord-030504-442pnl5s	146	2	Verification	verification	NN
cord-030504-442pnl5s	146	3	code	code	NN
cord-030504-442pnl5s	146	4	:	:	:
cord-030504-442pnl5s	146	5	053B-2FE3-F3E3	053b-2fe3-f3e3	CD
cord-030504-442pnl5s	146	6	-	-	HYPH
cord-030504-442pnl5s	146	7	887C-4651	887c-4651	CD
cord-030504-442pnl5s	146	8	)	)	-RRB-
cord-030504-442pnl5s	146	9	and	and	CC
cord-030504-442pnl5s	147	1	(	(	-LRB-
cord-030504-442pnl5s	147	2	Verification	Verification	NNP
cord-030504-442pnl5s	147	3	code	code	NN
cord-030504-442pnl5s	147	4	:	:	:
cord-030504-442pnl5s	147	5	0CA5	0ca5	CD
cord-030504-442pnl5s	147	6	-	-	HYPH
cord-030504-442pnl5s	147	7	4784-DED2-FED4	4784-ded2-fed4	CD
cord-030504-442pnl5s	147	8	-	-	SYM
cord-030504-442pnl5s	147	9	0F6A	0f6a	CD
cord-030504-442pnl5s	147	10	)	)	-RRB-
cord-030504-442pnl5s	147	11	for	for	IN
cord-030504-442pnl5s	147	12	providing	provide	VBG
cord-030504-442pnl5s	147	13	English	english	JJ
cord-030504-442pnl5s	147	14	language	language	NN
cord-030504-442pnl5s	147	15	editing	editing	NN
cord-030504-442pnl5s	147	16	services	service	NNS
cord-030504-442pnl5s	147	17	for	for	IN
cord-030504-442pnl5s	147	18	our	-PRON-	PRP$
cord-030504-442pnl5s	147	19	manuscript	manuscript	NN
cord-030504-442pnl5s	147	20	twice	twice	RB
cord-030504-442pnl5s	147	21	.	.	.
cord-030504-442pnl5s	148	1	Authors	author	NNS
cord-030504-442pnl5s	148	2	'	'	POS
cord-030504-442pnl5s	148	3	contributions	contribution	NNS
cord-030504-442pnl5s	148	4	DC	DC	NNP
cord-030504-442pnl5s	148	5	participated	participate	VBD
cord-030504-442pnl5s	148	6	in	in	IN
cord-030504-442pnl5s	148	7	the	the	DT
cord-030504-442pnl5s	148	8	design	design	NN
cord-030504-442pnl5s	148	9	of	of	IN
cord-030504-442pnl5s	148	10	the	the	DT
cord-030504-442pnl5s	148	11	study	study	NN
cord-030504-442pnl5s	148	12	.	.	.
cord-030504-442pnl5s	149	1	DC	DC	NNP
cord-030504-442pnl5s	149	2	,	,	,
cord-030504-442pnl5s	149	3	HS	HS	NNP
cord-030504-442pnl5s	149	4	and	and	CC
cord-030504-442pnl5s	149	5	MG	MG	NNP
cord-030504-442pnl5s	149	6	performed	perform	VBD
cord-030504-442pnl5s	149	7	the	the	DT
cord-030504-442pnl5s	149	8	data	datum	NNS
cord-030504-442pnl5s	149	9	collection	collection	NN
cord-030504-442pnl5s	149	10	and	and	CC
cord-030504-442pnl5s	149	11	statistical	statistical	JJ
cord-030504-442pnl5s	149	12	analysis	analysis	NN
cord-030504-442pnl5s	149	13	,	,	,
cord-030504-442pnl5s	149	14	and	and	CC
cord-030504-442pnl5s	149	15	DC	DC	NNP
cord-030504-442pnl5s	149	16	and	and	CC
cord-030504-442pnl5s	149	17	HS	HS	NNP
cord-030504-442pnl5s	149	18	drafted	draft	VBD
cord-030504-442pnl5s	149	19	the	the	DT
cord-030504-442pnl5s	149	20	manuscript	manuscript	NN
cord-030504-442pnl5s	149	21	.	.	.
cord-030504-442pnl5s	150	1	All	all	DT
cord-030504-442pnl5s	150	2	authors	author	NNS
cord-030504-442pnl5s	150	3	read	read	VBP
cord-030504-442pnl5s	150	4	and	and	CC
cord-030504-442pnl5s	150	5	approved	approve	VBD
cord-030504-442pnl5s	150	6	the	the	DT
cord-030504-442pnl5s	150	7	final	final	JJ
cord-030504-442pnl5s	150	8	manuscript	manuscript	NN
cord-030504-442pnl5s	150	9	.	.	.
cord-030504-442pnl5s	150	10	 	 	_SP