id sid tid token lemma pos cord-023584-yaxawqhj 1 1 key key JJ cord-023584-yaxawqhj 1 2 : : : cord-023584-yaxawqhj 1 3 cord-023584-yaxawqhj cord-023584-yaxawqhj . cord-023584-yaxawqhj 2 1 authors author NNS cord-023584-yaxawqhj 2 2 : : : cord-023584-yaxawqhj 2 3 Bucknall Bucknall NNP cord-023584-yaxawqhj 2 4 , , , cord-023584-yaxawqhj 3 1 R.A. R.A. NNP cord-023584-yaxawqhj 3 2 title title NN cord-023584-yaxawqhj 3 3 : : : cord-023584-yaxawqhj 3 4 The the DT cord-023584-yaxawqhj 3 5 Continuing Continuing NNP cord-023584-yaxawqhj 3 6 Search Search NNP cord-023584-yaxawqhj 3 7 for for IN cord-023584-yaxawqhj 3 8 Antiviral antiviral JJ cord-023584-yaxawqhj 3 9 Drugs Drugs NNPS cord-023584-yaxawqhj 3 10 date date NN cord-023584-yaxawqhj 3 11 : : : cord-023584-yaxawqhj 3 12 2008 2008 CD cord-023584-yaxawqhj 3 13 - - HYPH cord-023584-yaxawqhj 3 14 04 04 CD cord-023584-yaxawqhj 3 15 - - SYM cord-023584-yaxawqhj 3 16 10 10 CD cord-023584-yaxawqhj 3 17 journal journal NN cord-023584-yaxawqhj 3 18 : : : cord-023584-yaxawqhj 4 1 Adv Adv NNP cord-023584-yaxawqhj 4 2 Pharmacol Pharmacol NNP cord-023584-yaxawqhj 4 3 DOI DOI NNP cord-023584-yaxawqhj 4 4 : : : cord-023584-yaxawqhj 4 5 10.1016 10.1016 CD cord-023584-yaxawqhj 4 6 / / SYM cord-023584-yaxawqhj 4 7 s1054 s1054 NNP cord-023584-yaxawqhj 4 8 - - HYPH cord-023584-yaxawqhj 4 9 3589(08)60460 3589(08)60460 NNP cord-023584-yaxawqhj 4 10 - - HYPH cord-023584-yaxawqhj 4 11 3 3 CD cord-023584-yaxawqhj 4 12 sha sha NNP cord-023584-yaxawqhj 4 13 : : : cord-023584-yaxawqhj 5 1 75bdc9bf614eeefbad41fd687001b7773c7a4b9b 75bdc9bf614eeefbad41fd687001b7773c7a4b9b CD cord-023584-yaxawqhj 5 2 doc_id doc_id CD cord-023584-yaxawqhj 5 3 : : : cord-023584-yaxawqhj 5 4 23584 23584 CD cord-023584-yaxawqhj 5 5 cord_uid cord_uid NNS cord-023584-yaxawqhj 5 6 : : : cord-023584-yaxawqhj 6 1 yaxawqhj yaxawqhj NNP cord-023584-yaxawqhj 7 1 This this DT cord-023584-yaxawqhj 7 2 chapter chapter NN cord-023584-yaxawqhj 7 3 discusses discuss VBZ cord-023584-yaxawqhj 7 4 the the DT cord-023584-yaxawqhj 7 5 continuing continue VBG cord-023584-yaxawqhj 7 6 search search NN cord-023584-yaxawqhj 7 7 for for IN cord-023584-yaxawqhj 7 8 antiviral antiviral JJ cord-023584-yaxawqhj 7 9 drugs drug NNS cord-023584-yaxawqhj 7 10 . . . cord-023584-yaxawqhj 8 1 Many many JJ cord-023584-yaxawqhj 8 2 virus virus NN cord-023584-yaxawqhj 8 3 diseases disease NNS cord-023584-yaxawqhj 8 4 , , , cord-023584-yaxawqhj 8 5 both both DT cord-023584-yaxawqhj 8 6 of of IN cord-023584-yaxawqhj 8 7 humans human NNS cord-023584-yaxawqhj 8 8 and and CC cord-023584-yaxawqhj 8 9 animals animal NNS cord-023584-yaxawqhj 8 10 , , , cord-023584-yaxawqhj 8 11 have have VBP cord-023584-yaxawqhj 8 12 been be VBN cord-023584-yaxawqhj 8 13 successfully successfully RB cord-023584-yaxawqhj 8 14 controlled control VBN cord-023584-yaxawqhj 8 15 by by IN cord-023584-yaxawqhj 8 16 vaccines vaccine NNS cord-023584-yaxawqhj 8 17 . . . cord-023584-yaxawqhj 9 1 These these DT cord-023584-yaxawqhj 9 2 successes success NNS cord-023584-yaxawqhj 9 3 have have VBP cord-023584-yaxawqhj 9 4 naturally naturally RB cord-023584-yaxawqhj 9 5 led lead VBN cord-023584-yaxawqhj 9 6 to to IN cord-023584-yaxawqhj 9 7 improvements improvement NNS cord-023584-yaxawqhj 9 8 in in IN cord-023584-yaxawqhj 9 9 the the DT cord-023584-yaxawqhj 9 10 spectrum spectrum NN cord-023584-yaxawqhj 9 11 and and CC cord-023584-yaxawqhj 9 12 duration duration NN cord-023584-yaxawqhj 9 13 of of IN cord-023584-yaxawqhj 9 14 protection protection NN cord-023584-yaxawqhj 9 15 offered offer VBN cord-023584-yaxawqhj 9 16 by by IN cord-023584-yaxawqhj 9 17 vaccines vaccine NNS cord-023584-yaxawqhj 9 18 until until IN cord-023584-yaxawqhj 9 19 , , , cord-023584-yaxawqhj 9 20 at at IN cord-023584-yaxawqhj 9 21 present present NN cord-023584-yaxawqhj 9 22 it -PRON- PRP cord-023584-yaxawqhj 9 23 is be VBZ cord-023584-yaxawqhj 9 24 difficult difficult JJ cord-023584-yaxawqhj 9 25 to to TO cord-023584-yaxawqhj 9 26 see see VB cord-023584-yaxawqhj 9 27 how how WRB cord-023584-yaxawqhj 9 28 antiviral antiviral JJ cord-023584-yaxawqhj 9 29 drugs drug NNS cord-023584-yaxawqhj 9 30 could could MD cord-023584-yaxawqhj 9 31 compete compete VB cord-023584-yaxawqhj 9 32 with with IN cord-023584-yaxawqhj 9 33 vaccines vaccine NNS cord-023584-yaxawqhj 9 34 in in IN cord-023584-yaxawqhj 9 35 the the DT cord-023584-yaxawqhj 9 36 control control NN cord-023584-yaxawqhj 9 37 of of IN cord-023584-yaxawqhj 9 38 many many JJ cord-023584-yaxawqhj 9 39 virus virus NN cord-023584-yaxawqhj 9 40 diseases disease NNS cord-023584-yaxawqhj 9 41 . . . cord-023584-yaxawqhj 10 1 One one CD cord-023584-yaxawqhj 10 2 may may MD cord-023584-yaxawqhj 10 3 cite cite VB cord-023584-yaxawqhj 10 4 smallpox smallpox NN cord-023584-yaxawqhj 10 5 , , , cord-023584-yaxawqhj 10 6 yellow yellow JJ cord-023584-yaxawqhj 10 7 fever fever NN cord-023584-yaxawqhj 10 8 , , , cord-023584-yaxawqhj 10 9 polio polio NN cord-023584-yaxawqhj 10 10 , , , cord-023584-yaxawqhj 10 11 and and CC cord-023584-yaxawqhj 10 12 recently recently RB cord-023584-yaxawqhj 10 13 measles measle NNS cord-023584-yaxawqhj 10 14 among among IN cord-023584-yaxawqhj 10 15 human human JJ cord-023584-yaxawqhj 10 16 diseases disease NNS cord-023584-yaxawqhj 10 17 , , , cord-023584-yaxawqhj 11 1 Newcastle Newcastle NNP cord-023584-yaxawqhj 11 2 disease disease NN cord-023584-yaxawqhj 11 3 , , , cord-023584-yaxawqhj 11 4 Marek Marek NNP cord-023584-yaxawqhj 11 5 's 's POS cord-023584-yaxawqhj 11 6 disease disease NN cord-023584-yaxawqhj 11 7 , , , cord-023584-yaxawqhj 11 8 and and CC cord-023584-yaxawqhj 11 9 infectious infectious JJ cord-023584-yaxawqhj 11 10 bronchitis bronchitis NN cord-023584-yaxawqhj 11 11 among among IN cord-023584-yaxawqhj 11 12 poultry poultry NN cord-023584-yaxawqhj 11 13 diseases disease NNS cord-023584-yaxawqhj 11 14 — — : cord-023584-yaxawqhj 11 15 an an DT cord-023584-yaxawqhj 11 16 area area NN cord-023584-yaxawqhj 11 17 of of IN cord-023584-yaxawqhj 11 18 veterinary veterinary JJ cord-023584-yaxawqhj 11 19 disease disease NN cord-023584-yaxawqhj 11 20 control control NN cord-023584-yaxawqhj 11 21 where where WRB cord-023584-yaxawqhj 11 22 vaccines vaccine NNS cord-023584-yaxawqhj 11 23 have have VBP cord-023584-yaxawqhj 11 24 been be VBN cord-023584-yaxawqhj 11 25 particularly particularly RB cord-023584-yaxawqhj 11 26 important important JJ cord-023584-yaxawqhj 11 27 . . . cord-023584-yaxawqhj 12 1 Research research NN cord-023584-yaxawqhj 12 2 into into IN cord-023584-yaxawqhj 12 3 the the DT cord-023584-yaxawqhj 12 4 treatment treatment NN cord-023584-yaxawqhj 12 5 of of IN cord-023584-yaxawqhj 12 6 virus virus NN cord-023584-yaxawqhj 12 7 diseases disease NNS cord-023584-yaxawqhj 12 8 by by IN cord-023584-yaxawqhj 12 9 drugs drug NNS cord-023584-yaxawqhj 12 10 is be VBZ cord-023584-yaxawqhj 12 11 at at IN cord-023584-yaxawqhj 12 12 present present JJ cord-023584-yaxawqhj 12 13 directed direct VBN cord-023584-yaxawqhj 12 14 toward toward IN cord-023584-yaxawqhj 12 15 three three CD cord-023584-yaxawqhj 12 16 general general JJ cord-023584-yaxawqhj 12 17 areas area NNS cord-023584-yaxawqhj 12 18 : : : cord-023584-yaxawqhj 12 19 ( ( -LRB- cord-023584-yaxawqhj 12 20 1 1 LS cord-023584-yaxawqhj 12 21 ) ) -RRB- cord-023584-yaxawqhj 12 22 attempts attempt VBZ cord-023584-yaxawqhj 12 23 to to TO cord-023584-yaxawqhj 12 24 stimulate stimulate VB cord-023584-yaxawqhj 12 25 the the DT cord-023584-yaxawqhj 12 26 defense defense NN cord-023584-yaxawqhj 12 27 mechanism mechanism NN cord-023584-yaxawqhj 12 28 of of IN cord-023584-yaxawqhj 12 29 the the DT cord-023584-yaxawqhj 12 30 host host NN cord-023584-yaxawqhj 12 31 animal animal NN cord-023584-yaxawqhj 12 32 , , , cord-023584-yaxawqhj 12 33 ( ( -LRB- cord-023584-yaxawqhj 12 34 2 2 LS cord-023584-yaxawqhj 12 35 ) ) -RRB- cord-023584-yaxawqhj 12 36 large large JJ cord-023584-yaxawqhj 12 37 screening screening NN cord-023584-yaxawqhj 12 38 programs program NNS cord-023584-yaxawqhj 12 39 to to TO cord-023584-yaxawqhj 12 40 find find VB cord-023584-yaxawqhj 12 41 drugs drug NNS cord-023584-yaxawqhj 12 42 which which WDT cord-023584-yaxawqhj 12 43 directly directly RB cord-023584-yaxawqhj 12 44 block block VBP cord-023584-yaxawqhj 12 45 some some DT cord-023584-yaxawqhj 12 46 virus virus NN cord-023584-yaxawqhj 12 47 - - HYPH cord-023584-yaxawqhj 12 48 specific specific JJ cord-023584-yaxawqhj 12 49 process process NN cord-023584-yaxawqhj 12 50 , , , cord-023584-yaxawqhj 12 51 and and CC cord-023584-yaxawqhj 12 52 ( ( -LRB- cord-023584-yaxawqhj 12 53 3 3 LS cord-023584-yaxawqhj 12 54 ) ) -RRB- cord-023584-yaxawqhj 12 55 alleviation alleviation NN cord-023584-yaxawqhj 12 56 of of IN cord-023584-yaxawqhj 12 57 the the DT cord-023584-yaxawqhj 12 58 symptoms symptom NNS cord-023584-yaxawqhj 12 59 of of IN cord-023584-yaxawqhj 12 60 the the DT cord-023584-yaxawqhj 12 61 disease disease NN cord-023584-yaxawqhj 12 62 . . . cord-023584-yaxawqhj 13 1 The the DT cord-023584-yaxawqhj 13 2 treatment treatment NN cord-023584-yaxawqhj 13 3 of of IN cord-023584-yaxawqhj 13 4 the the DT cord-023584-yaxawqhj 13 5 symptoms symptom NNS cord-023584-yaxawqhj 13 6 , , , cord-023584-yaxawqhj 13 7 rather rather RB cord-023584-yaxawqhj 13 8 than than IN cord-023584-yaxawqhj 13 9 the the DT cord-023584-yaxawqhj 13 10 cause cause NN cord-023584-yaxawqhj 13 11 of of IN cord-023584-yaxawqhj 13 12 a a DT cord-023584-yaxawqhj 13 13 disease disease NN cord-023584-yaxawqhj 13 14 , , , cord-023584-yaxawqhj 13 15 has have VBZ cord-023584-yaxawqhj 13 16 been be VBN cord-023584-yaxawqhj 13 17 the the DT cord-023584-yaxawqhj 13 18 mainstay mainstay NN cord-023584-yaxawqhj 13 19 of of IN cord-023584-yaxawqhj 13 20 medical medical JJ cord-023584-yaxawqhj 13 21 practice practice NN cord-023584-yaxawqhj 13 22 from from IN cord-023584-yaxawqhj 13 23 time time NN cord-023584-yaxawqhj 13 24 immemorial immemorial JJ cord-023584-yaxawqhj 13 25 , , , cord-023584-yaxawqhj 13 26 and and CC cord-023584-yaxawqhj 13 27 this this DT cord-023584-yaxawqhj 13 28 is be VBZ cord-023584-yaxawqhj 13 29 still still RB cord-023584-yaxawqhj 13 30 the the DT cord-023584-yaxawqhj 13 31 case case NN cord-023584-yaxawqhj 13 32 with with IN cord-023584-yaxawqhj 13 33 most most JJS cord-023584-yaxawqhj 13 34 virus virus NN cord-023584-yaxawqhj 13 35 disease disease NN cord-023584-yaxawqhj 13 36 . . . cord-023584-yaxawqhj 14 1 The the DT cord-023584-yaxawqhj 14 2 short short JJ cord-023584-yaxawqhj 14 3 incubation incubation NN cord-023584-yaxawqhj 14 4 period period NN cord-023584-yaxawqhj 14 5 of of IN cord-023584-yaxawqhj 14 6 many many JJ cord-023584-yaxawqhj 14 7 virus virus NN cord-023584-yaxawqhj 14 8 diseases disease NNS cord-023584-yaxawqhj 14 9 will will MD cord-023584-yaxawqhj 14 10 inevitably inevitably RB cord-023584-yaxawqhj 14 11 restrict restrict VB cord-023584-yaxawqhj 14 12 the the DT cord-023584-yaxawqhj 14 13 therapeutic therapeutic JJ cord-023584-yaxawqhj 14 14 use use NN cord-023584-yaxawqhj 14 15 of of IN cord-023584-yaxawqhj 14 16 antiviral antiviral JJ cord-023584-yaxawqhj 14 17 drugs drug NNS cord-023584-yaxawqhj 14 18 and and CC cord-023584-yaxawqhj 14 19 in in IN cord-023584-yaxawqhj 14 20 cases case NNS cord-023584-yaxawqhj 14 21 where where WRB cord-023584-yaxawqhj 14 22 symptoms symptom NNS cord-023584-yaxawqhj 14 23 have have VBP cord-023584-yaxawqhj 14 24 already already RB cord-023584-yaxawqhj 14 25 appeared appear VBN cord-023584-yaxawqhj 14 26 . . . cord-023584-yaxawqhj 15 1 Although although IN cord-023584-yaxawqhj 15 2 research research NN cord-023584-yaxawqhj 15 3 into into IN cord-023584-yaxawqhj 15 4 the the DT cord-023584-yaxawqhj 15 5 mechanisms mechanism NNS cord-023584-yaxawqhj 15 6 of of IN cord-023584-yaxawqhj 15 7 virus virus NN cord-023584-yaxawqhj 15 8 infection infection NN cord-023584-yaxawqhj 15 9 is be VBZ cord-023584-yaxawqhj 15 10 carried carry VBN cord-023584-yaxawqhj 15 11 out out RP cord-023584-yaxawqhj 15 12 by by IN cord-023584-yaxawqhj 15 13 many many JJ cord-023584-yaxawqhj 15 14 sections section NNS cord-023584-yaxawqhj 15 15 of of IN cord-023584-yaxawqhj 15 16 the the DT cord-023584-yaxawqhj 15 17 scientific scientific JJ cord-023584-yaxawqhj 15 18 community community NN cord-023584-yaxawqhj 15 19 , , , cord-023584-yaxawqhj 15 20 the the DT cord-023584-yaxawqhj 15 21 search search NN cord-023584-yaxawqhj 15 22 for for IN cord-023584-yaxawqhj 15 23 antiviral antiviral JJ cord-023584-yaxawqhj 15 24 drugs drug NNS cord-023584-yaxawqhj 15 25 is be VBZ cord-023584-yaxawqhj 15 26 almost almost RB cord-023584-yaxawqhj 15 27 exclusively exclusively RB cord-023584-yaxawqhj 15 28 the the DT cord-023584-yaxawqhj 15 29 province province NN cord-023584-yaxawqhj 15 30 of of IN cord-023584-yaxawqhj 15 31 pharmaceutical pharmaceutical JJ cord-023584-yaxawqhj 15 32 manufacturers manufacturer NNS cord-023584-yaxawqhj 15 33 . . . cord-023584-yaxawqhj 16 1 The the DT cord-023584-yaxawqhj 16 2 reasons reason NNS cord-023584-yaxawqhj 16 3 for for IN cord-023584-yaxawqhj 16 4 this this DT cord-023584-yaxawqhj 16 5 are be VBP cord-023584-yaxawqhj 16 6 partly partly RB cord-023584-yaxawqhj 16 7 historical historical JJ cord-023584-yaxawqhj 16 8 , , , cord-023584-yaxawqhj 16 9 but but CC cord-023584-yaxawqhj 16 10 chiefly chiefly RB cord-023584-yaxawqhj 16 11 it -PRON- PRP cord-023584-yaxawqhj 16 12 is be VBZ cord-023584-yaxawqhj 16 13 because because IN cord-023584-yaxawqhj 16 14 the the DT cord-023584-yaxawqhj 16 15 facilities facility NNS cord-023584-yaxawqhj 16 16 for for IN cord-023584-yaxawqhj 16 17 running run VBG cord-023584-yaxawqhj 16 18 large large JJ cord-023584-yaxawqhj 16 19 - - HYPH cord-023584-yaxawqhj 16 20 scale scale NN cord-023584-yaxawqhj 16 21 screening screening NN cord-023584-yaxawqhj 16 22 programs program NNS cord-023584-yaxawqhj 16 23 are be VBP cord-023584-yaxawqhj 16 24 expensive expensive JJ cord-023584-yaxawqhj 16 25 and and CC cord-023584-yaxawqhj 16 26 can can MD cord-023584-yaxawqhj 16 27 only only RB cord-023584-yaxawqhj 16 28 be be VB cord-023584-yaxawqhj 16 29 met meet VBN cord-023584-yaxawqhj 16 30 by by IN cord-023584-yaxawqhj 16 31 commercial commercial JJ cord-023584-yaxawqhj 16 32 and and CC cord-023584-yaxawqhj 16 33 , , , cord-023584-yaxawqhj 16 34 occasionally occasionally RB cord-023584-yaxawqhj 16 35 , , , cord-023584-yaxawqhj 16 36 governmental governmental JJ cord-023584-yaxawqhj 16 37 resources resource NNS cord-023584-yaxawqhj 16 38 . . . cord-023584-yaxawqhj 17 1 Because because IN cord-023584-yaxawqhj 17 2 of of IN cord-023584-yaxawqhj 17 3 the the DT cord-023584-yaxawqhj 17 4 need need NN cord-023584-yaxawqhj 17 5 to to TO cord-023584-yaxawqhj 17 6 protect protect VB cord-023584-yaxawqhj 17 7 their -PRON- PRP$ cord-023584-yaxawqhj 17 8 discoveries discovery NNS cord-023584-yaxawqhj 17 9 from from IN cord-023584-yaxawqhj 17 10 unauthorized unauthorized JJ cord-023584-yaxawqhj 17 11 exploitation exploitation NN cord-023584-yaxawqhj 17 12 , , , cord-023584-yaxawqhj 17 13 a a DT cord-023584-yaxawqhj 17 14 good good JJ cord-023584-yaxawqhj 17 15 deal deal NN cord-023584-yaxawqhj 17 16 of of IN cord-023584-yaxawqhj 17 17 secrecy secrecy NN cord-023584-yaxawqhj 17 18 inevitably inevitably RB cord-023584-yaxawqhj 17 19 surrounds surround VBZ cord-023584-yaxawqhj 17 20 the the DT cord-023584-yaxawqhj 17 21 work work NN cord-023584-yaxawqhj 17 22 being be VBG cord-023584-yaxawqhj 17 23 carried carry VBN cord-023584-yaxawqhj 17 24 out out RP cord-023584-yaxawqhj 17 25 in in IN cord-023584-yaxawqhj 17 26 commercial commercial JJ cord-023584-yaxawqhj 17 27 organizations organization NNS cord-023584-yaxawqhj 17 28 . . . cord-023584-yaxawqhj 18 1 This this DT cord-023584-yaxawqhj 18 2 secrecy secrecy NN cord-023584-yaxawqhj 18 3 is be VBZ cord-023584-yaxawqhj 18 4 regrettable regrettable JJ cord-023584-yaxawqhj 18 5 but but CC cord-023584-yaxawqhj 18 6 necessary necessary JJ cord-023584-yaxawqhj 18 7 , , , cord-023584-yaxawqhj 18 8 since since IN cord-023584-yaxawqhj 18 9 the the DT cord-023584-yaxawqhj 18 10 survival survival NN cord-023584-yaxawqhj 18 11 of of IN cord-023584-yaxawqhj 18 12 such such JJ cord-023584-yaxawqhj 18 13 organizations organization NNS cord-023584-yaxawqhj 18 14 depends depend VBZ cord-023584-yaxawqhj 18 15 largely largely RB cord-023584-yaxawqhj 18 16 then then RB cord-023584-yaxawqhj 18 17 on on IN cord-023584-yaxawqhj 18 18 getting get VBG cord-023584-yaxawqhj 18 19 a a DT cord-023584-yaxawqhj 18 20 fair fair JJ cord-023584-yaxawqhj 18 21 financial financial JJ cord-023584-yaxawqhj 18 22 return return NN cord-023584-yaxawqhj 18 23 on on IN cord-023584-yaxawqhj 18 24 the the DT cord-023584-yaxawqhj 18 25 money money NN cord-023584-yaxawqhj 18 26 invested invest VBN cord-023584-yaxawqhj 18 27 by by IN cord-023584-yaxawqhj 18 28 them -PRON- PRP cord-023584-yaxawqhj 18 29 in in IN cord-023584-yaxawqhj 18 30 research research NN cord-023584-yaxawqhj 18 31 . . . cord-023584-yaxawqhj 19 1 The the DT cord-023584-yaxawqhj 19 2 security security NN cord-023584-yaxawqhj 19 3 aspects aspect NNS cord-023584-yaxawqhj 19 4 of of IN cord-023584-yaxawqhj 19 5 commercial commercial JJ cord-023584-yaxawqhj 19 6 research research NN cord-023584-yaxawqhj 19 7 naturally naturally RB cord-023584-yaxawqhj 19 8 restrict restrict VBP cord-023584-yaxawqhj 19 9 frank frank JJ cord-023584-yaxawqhj 19 10 and and CC cord-023584-yaxawqhj 19 11 constructive constructive JJ cord-023584-yaxawqhj 19 12 discussions discussion NNS cord-023584-yaxawqhj 19 13 between between IN cord-023584-yaxawqhj 19 14 competitors competitor NNS cord-023584-yaxawqhj 19 15 as as RB cord-023584-yaxawqhj 19 16 well well RB cord-023584-yaxawqhj 19 17 as as IN cord-023584-yaxawqhj 19 18 third third JJ cord-023584-yaxawqhj 19 19 parties party NNS cord-023584-yaxawqhj 19 20 , , , cord-023584-yaxawqhj 19 21 and and CC cord-023584-yaxawqhj 19 22 this this DT cord-023584-yaxawqhj 19 23 has have VBZ cord-023584-yaxawqhj 19 24 been be VBN cord-023584-yaxawqhj 19 25 particularly particularly RB cord-023584-yaxawqhj 19 26 true true JJ cord-023584-yaxawqhj 19 27 in in IN cord-023584-yaxawqhj 19 28 antiviral antiviral JJ cord-023584-yaxawqhj 19 29 research research NN cord-023584-yaxawqhj 19 30 . . . cord-023584-yaxawqhj 20 1 Perhaps perhaps RB cord-023584-yaxawqhj 20 2 it -PRON- PRP cord-023584-yaxawqhj 20 3 was be VBD cord-023584-yaxawqhj 20 4 a a DT cord-023584-yaxawqhj 20 5 revolt revolt NN cord-023584-yaxawqhj 20 6 against against IN cord-023584-yaxawqhj 20 7 this this DT cord-023584-yaxawqhj 20 8 enforced enforce VBN cord-023584-yaxawqhj 20 9 isolationism isolationism NN cord-023584-yaxawqhj 20 10 which which WDT cord-023584-yaxawqhj 20 11 led lead VBD cord-023584-yaxawqhj 20 12 , , , cord-023584-yaxawqhj 20 13 at at IN cord-023584-yaxawqhj 20 14 least least JJS cord-023584-yaxawqhj 20 15 in in IN cord-023584-yaxawqhj 20 16 part part NN cord-023584-yaxawqhj 20 17 , , , cord-023584-yaxawqhj 20 18 to to IN cord-023584-yaxawqhj 20 19 the the DT cord-023584-yaxawqhj 20 20 first first JJ cord-023584-yaxawqhj 20 21 Conference Conference NNP cord-023584-yaxawqhj 20 22 on on IN cord-023584-yaxawqhj 20 23 Antiviral Antiviral NNP cord-023584-yaxawqhj 20 24 Substance Substance NNP cord-023584-yaxawqhj 20 25 's 's POS cord-023584-yaxawqhj 20 26 held hold VBN cord-023584-yaxawqhj 20 27 by by IN cord-023584-yaxawqhj 20 28 the the DT cord-023584-yaxawqhj 20 29 New New NNP cord-023584-yaxawqhj 20 30 York York NNP cord-023584-yaxawqhj 20 31 Academy Academy NNP cord-023584-yaxawqhj 20 32 of of IN cord-023584-yaxawqhj 20 33 Sciences Sciences NNPS cord-023584-yaxawqhj 20 34 in in IN cord-023584-yaxawqhj 20 35 1965 1965 CD cord-023584-yaxawqhj 20 36 , , , cord-023584-yaxawqhj 20 37 in in IN cord-023584-yaxawqhj 20 38 which which WDT cord-023584-yaxawqhj 20 39 manufacturers manufacturer NNS cord-023584-yaxawqhj 20 40 disclosed disclose VBD cord-023584-yaxawqhj 20 41 many many JJ cord-023584-yaxawqhj 20 42 of of IN cord-023584-yaxawqhj 20 43 the the DT cord-023584-yaxawqhj 20 44 details detail NNS cord-023584-yaxawqhj 20 45 of of IN cord-023584-yaxawqhj 20 46 their -PRON- PRP$ cord-023584-yaxawqhj 20 47 antiviral antiviral JJ cord-023584-yaxawqhj 20 48 research research NN cord-023584-yaxawqhj 20 49 and and CC cord-023584-yaxawqhj 20 50 had have VBD cord-023584-yaxawqhj 20 51 a a DT cord-023584-yaxawqhj 20 52 chance chance NN cord-023584-yaxawqhj 20 53 to to TO cord-023584-yaxawqhj 20 54 discuss discuss VB cord-023584-yaxawqhj 20 55 their -PRON- PRP$ cord-023584-yaxawqhj 20 56 failures failure NNS cord-023584-yaxawqhj 20 57 and and CC cord-023584-yaxawqhj 20 58 comparative comparative JJ cord-023584-yaxawqhj 20 59 successes success NNS cord-023584-yaxawqhj 20 60 ( ( -LRB- cord-023584-yaxawqhj 20 61 Whipple Whipple NNP cord-023584-yaxawqhj 20 62 , , , cord-023584-yaxawqhj 20 63 1965 1965 CD cord-023584-yaxawqhj 20 64 ) ) -RRB- cord-023584-yaxawqhj 20 65 . . . cord-023584-yaxawqhj 21 1 295 295 CD cord-023584-yaxawqhj 22 1 Since since IN cord-023584-yaxawqhj 22 2 then then RB cord-023584-yaxawqhj 22 3 there there EX cord-023584-yaxawqhj 22 4 have have VBP cord-023584-yaxawqhj 22 5 been be VBN cord-023584-yaxawqhj 22 6 a a DT cord-023584-yaxawqhj 22 7 number number NN cord-023584-yaxawqhj 22 8 of of IN cord-023584-yaxawqhj 22 9 reviews review NNS cord-023584-yaxawqhj 22 10 of of IN cord-023584-yaxawqhj 22 11 progress progress NN cord-023584-yaxawqhj 22 12 in in IN cord-023584-yaxawqhj 22 13 the the DT cord-023584-yaxawqhj 22 14 field field NN cord-023584-yaxawqhj 22 15 of of IN cord-023584-yaxawqhj 22 16 antiviral antiviral JJ cord-023584-yaxawqhj 22 17 chemothrrapy chemothrrapy NN cord-023584-yaxawqhj 22 18 , , , cord-023584-yaxawqhj 22 19 and and CC cord-023584-yaxawqhj 22 20 in in IN cord-023584-yaxawqhj 22 21 most most JJS cord-023584-yaxawqhj 22 22 of of IN cord-023584-yaxawqhj 22 23 these these DT cord-023584-yaxawqhj 22 24 there there EX cord-023584-yaxawqhj 22 25 have have VBP cord-023584-yaxawqhj 22 26 appeared appear VBN cord-023584-yaxawqhj 22 27 comments comment NNS cord-023584-yaxawqhj 22 28 and and CC cord-023584-yaxawqhj 22 29 recommendations recommendation NNS cord-023584-yaxawqhj 23 1 Ivhich Ivhich NNP cord-023584-yaxawqhj 23 2 indicate indicate VBP cord-023584-yaxawqhj 23 3 that that IN cord-023584-yaxawqhj 23 4 a a DT cord-023584-yaxawqhj 23 5 radical radical JJ cord-023584-yaxawqhj 23 6 rethinking rethinking NN cord-023584-yaxawqhj 23 7 is be VBZ cord-023584-yaxawqhj 23 8 taking take VBG cord-023584-yaxawqhj 23 9 place place NN cord-023584-yaxawqhj 23 10 of of IN cord-023584-yaxawqhj 23 11 the the DT cord-023584-yaxawqhj 23 12 prospects prospect NNS cord-023584-yaxawqhj 23 13 for for IN cord-023584-yaxawqhj 23 14 antiviral antiviral JJ cord-023584-yaxawqhj 23 15 drugs drug NNS cord-023584-yaxawqhj 23 16 ( ( -LRB- cord-023584-yaxawqhj 23 17 Osdene Osdene NNP cord-023584-yaxawqhj 23 18 , , , cord-023584-yaxawqhj 23 19 1967 1967 CD cord-023584-yaxawqhj 23 20 ; ; : cord-023584-yaxawqhj 23 21 McFadzean McFadzean NNP cord-023584-yaxawqhj 23 22 , , , cord-023584-yaxawqhj 23 23 1969 1969 CD cord-023584-yaxawqhj 23 24 ; ; : cord-023584-yaxawqhj 23 25 Goz Goz NNP cord-023584-yaxawqhj 23 26 and and CC cord-023584-yaxawqhj 23 27 Prusoff Prusoff NNP cord-023584-yaxawqhj 23 28 , , , cord-023584-yaxawqhj 23 29 1970 1970 CD cord-023584-yaxawqhj 23 30 ; ; : cord-023584-yaxawqhj 23 31 Swallow Swallow NNP cord-023584-yaxawqhj 23 32 , , , cord-023584-yaxawqhj 23 33 1971 1971 CD cord-023584-yaxawqhj 23 34 ) ) -RRB- cord-023584-yaxawqhj 23 35 . . . cord-023584-yaxawqhj 24 1 It -PRON- PRP cord-023584-yaxawqhj 24 2 was be VBD cord-023584-yaxawqhj 24 3 natural natural JJ cord-023584-yaxawqhj 24 4 in in IN cord-023584-yaxawqhj 24 5 the the DT cord-023584-yaxawqhj 24 6 early early JJ cord-023584-yaxawqhj 24 7 1950s 1950 NNS cord-023584-yaxawqhj 24 8 to to TO cord-023584-yaxawqhj 24 9 espect espect VB cord-023584-yaxawqhj 24 10 that that IN cord-023584-yaxawqhj 24 11 antiviral antiviral JJ cord-023584-yaxawqhj 24 12 drugs drug NNS cord-023584-yaxawqhj 24 13 would would MD cord-023584-yaxawqhj 24 14 be be VB cord-023584-yaxawqhj 24 15 discoverrd discoverrd NN cord-023584-yaxawqhj 24 16 which which WDT cord-023584-yaxawqhj 24 17 would would MD cord-023584-yaxawqhj 24 18 be be VB cord-023584-yaxawqhj 24 19 analogous analogous JJ cord-023584-yaxawqhj 24 20 to to IN cord-023584-yaxawqhj 24 21 the the DT cord-023584-yaxawqhj 24 22 antibacterial antibacterial JJ cord-023584-yaxawqhj 24 23 antibiotics antibiotic NNS cord-023584-yaxawqhj 24 24 , , , cord-023584-yaxawqhj 24 25 the the DT cord-023584-yaxawqhj 24 26 darlings darling NNS cord-023584-yaxawqhj 24 27 of of IN cord-023584-yaxawqhj 24 28 the the DT cord-023584-yaxawqhj 24 29 prrvious prrvious JJ cord-023584-yaxawqhj 24 30 decade decade NN cord-023584-yaxawqhj 24 31 . . . cord-023584-yaxawqhj 25 1 The the DT cord-023584-yaxawqhj 25 2 experience experience NN cord-023584-yaxawqhj 25 3 up up IN cord-023584-yaxawqhj 25 4 to to IN cord-023584-yaxawqhj 25 5 date date NN cord-023584-yaxawqhj 25 6 has have VBZ cord-023584-yaxawqhj 25 7 proved prove VBN cord-023584-yaxawqhj 25 8 that that IN cord-023584-yaxawqhj 25 9 this this DT cord-023584-yaxawqhj 25 10 was be VBD cord-023584-yaxawqhj 25 11 not not RB cord-023584-yaxawqhj 25 12 to to TO cord-023584-yaxawqhj 25 13 br br VB cord-023584-yaxawqhj 25 14 the the DT cord-023584-yaxawqhj 25 15 case case NN cord-023584-yaxawqhj 25 16 , , , cord-023584-yaxawqhj 25 17 and and CC cord-023584-yaxawqhj 25 18 despite despite IN cord-023584-yaxawqhj 25 19 prodigious prodigious JJ cord-023584-yaxawqhj 25 20 efforts effort NNS cord-023584-yaxawqhj 25 21 by by IN cord-023584-yaxawqhj 25 22 the the DT cord-023584-yaxawqhj 25 23 drug drug NN cord-023584-yaxawqhj 25 24 houses house NNS cord-023584-yaxawqhj 25 25 , , , cord-023584-yaxawqhj 25 26 only only RB cord-023584-yaxawqhj 25 27 three three CD cord-023584-yaxawqhj 25 28 clinically clinically RB cord-023584-yaxawqhj 25 29 useful useful JJ cord-023584-yaxawqhj 25 30 antiviral antiviral JJ cord-023584-yaxawqhj 25 31 agents agent NNS cord-023584-yaxawqhj 25 32 , , , cord-023584-yaxawqhj 25 33 which which WDT cord-023584-yaxawqhj 25 34 are be VBP cord-023584-yaxawqhj 25 35 far far RB cord-023584-yaxawqhj 25 36 from from IN cord-023584-yaxawqhj 25 37 perfect perfect JJ cord-023584-yaxawqhj 25 38 , , , cord-023584-yaxawqhj 25 39 have have VBP cord-023584-yaxawqhj 25 40 emerged emerge VBN cord-023584-yaxawqhj 25 41 . . . cord-023584-yaxawqhj 26 1 I -PRON- PRP cord-023584-yaxawqhj 26 2 believe believe VBP cord-023584-yaxawqhj 26 3 thcre thcre NNS cord-023584-yaxawqhj 26 4 are be VBP cord-023584-yaxawqhj 26 5 lessons lesson NNS cord-023584-yaxawqhj 26 6 to to TO cord-023584-yaxawqhj 26 7 be be VB cord-023584-yaxawqhj 26 8 learned learn VBN cord-023584-yaxawqhj 26 9 from from IN cord-023584-yaxawqhj 26 10 this this DT cord-023584-yaxawqhj 26 11 disappointing disappointing JJ cord-023584-yaxawqhj 26 12 record record NN cord-023584-yaxawqhj 26 13 , , , cord-023584-yaxawqhj 26 14 and and CC cord-023584-yaxawqhj 26 15 I -PRON- PRP cord-023584-yaxawqhj 26 16 hope hope VBP cord-023584-yaxawqhj 26 17 that that IN cord-023584-yaxawqhj 26 18 the the DT cord-023584-yaxawqhj 26 19 following follow VBG cord-023584-yaxawqhj 26 20 remarks remark NNS cord-023584-yaxawqhj 26 21 may may MD cord-023584-yaxawqhj 26 22 help help VB cord-023584-yaxawqhj 26 23 to to TO cord-023584-yaxawqhj 26 24 continue continue VB cord-023584-yaxawqhj 26 25 further further RB cord-023584-yaxawqhj 26 26 the the DT cord-023584-yaxawqhj 26 27 critical critical JJ cord-023584-yaxawqhj 26 28 reappraisal reappraisal NN cord-023584-yaxawqhj 26 29 of of IN cord-023584-yaxawqhj 26 30 this this DT cord-023584-yaxawqhj 26 31 field field NN cord-023584-yaxawqhj 26 32 , , , cord-023584-yaxawqhj 26 33 so so IN cord-023584-yaxawqhj 26 34 that that IN cord-023584-yaxawqhj 26 35 future future JJ cord-023584-yaxawqhj 26 36 progress progress NN cord-023584-yaxawqhj 26 37 may may MD cord-023584-yaxawqhj 26 38 be be VB cord-023584-yaxawqhj 26 39 faster fast JJR cord-023584-yaxawqhj 26 40 . . . cord-023584-yaxawqhj 27 1 Before before IN cord-023584-yaxawqhj 27 2 embarking embark VBG cord-023584-yaxawqhj 27 3 on on IN cord-023584-yaxawqhj 27 4 a a DT cord-023584-yaxawqhj 27 5 search search NN cord-023584-yaxawqhj 27 6 for for IN cord-023584-yaxawqhj 27 7 antiviral antiviral JJ cord-023584-yaxawqhj 27 8 drugs drug NNS cord-023584-yaxawqhj 27 9 , , , cord-023584-yaxawqhj 27 10 a a DT cord-023584-yaxawqhj 27 11 number number NN cord-023584-yaxawqhj 27 12 of of IN cord-023584-yaxawqhj 27 13 points point NNS cord-023584-yaxawqhj 27 14 must must MD cord-023584-yaxawqhj 27 15 be be VB cord-023584-yaxawqhj 27 16 considered consider VBN cord-023584-yaxawqhj 27 17 in in IN cord-023584-yaxawqhj 27 18 order order NN cord-023584-yaxawqhj 27 19 to to TO cord-023584-yaxawqhj 27 20 assess assess VB cord-023584-yaxawqhj 27 21 thr thr NNP cord-023584-yaxawqhj 27 22 technical technical JJ cord-023584-yaxawqhj 27 23 feasibility feasibility NN cord-023584-yaxawqhj 27 24 of of IN cord-023584-yaxawqhj 27 25 treating treat VBG cord-023584-yaxawqhj 27 26 or or CC cord-023584-yaxawqhj 27 27 preventing prevent VBG cord-023584-yaxawqhj 27 28 a a DT cord-023584-yaxawqhj 27 29 virus virus NN cord-023584-yaxawqhj 27 30 disrase disrase NN cord-023584-yaxawqhj 27 31 u u NNP cord-023584-yaxawqhj 27 32 - - HYPH cord-023584-yaxawqhj 27 33 ith ith NNP cord-023584-yaxawqhj 27 34 a a DT cord-023584-yaxawqhj 27 35 drug drug NN cord-023584-yaxawqhj 27 36 . . . cord-023584-yaxawqhj 28 1 Too too RB cord-023584-yaxawqhj 28 2 often often RB cord-023584-yaxawqhj 28 3 in in IN cord-023584-yaxawqhj 28 4 the the DT cord-023584-yaxawqhj 28 5 past past JJ cord-023584-yaxawqhj 28 6 massive massive JJ cord-023584-yaxawqhj 28 7 screens screen NNS cord-023584-yaxawqhj 28 8 have have VBP cord-023584-yaxawqhj 28 9 bccn bccn NNP cord-023584-yaxawqhj 28 10 set set VBN cord-023584-yaxawqhj 28 11 up up RP cord-023584-yaxawqhj 28 12 against against IN cord-023584-yaxawqhj 28 13 many many JJ cord-023584-yaxawqhj 28 14 viruses virus NNS cord-023584-yaxawqhj 28 15 in in IN cord-023584-yaxawqhj 28 16 the the DT cord-023584-yaxawqhj 28 17 hope hope NN cord-023584-yaxawqhj 28 18 that that IN cord-023584-yaxawqhj 28 19 a a DT cord-023584-yaxawqhj 28 20 drug drug NN cord-023584-yaxawqhj 28 21 would would MD cord-023584-yaxawqhj 28 22 turn turn VB cord-023584-yaxawqhj 28 23 up up RP cord-023584-yaxawqhj 28 24 , , , cord-023584-yaxawqhj 28 25 and and CC cord-023584-yaxawqhj 28 26 it -PRON- PRP cord-023584-yaxawqhj 28 27 would would MD cord-023584-yaxawqhj 28 28 then then RB cord-023584-yaxawqhj 28 29 find find VB cord-023584-yaxawqhj 28 30 a a DT cord-023584-yaxawqhj 28 31 natural natural JJ cord-023584-yaxawqhj 28 32 place place NN cord-023584-yaxawqhj 28 33 in in IN cord-023584-yaxawqhj 28 34 human human JJ cord-023584-yaxawqhj 28 35 or or CC cord-023584-yaxawqhj 28 36 veterinary veterinary JJ cord-023584-yaxawqhj 28 37 medicine medicine NN cord-023584-yaxawqhj 28 38 . . . cord-023584-yaxawqhj 29 1 Although although IN cord-023584-yaxawqhj 29 2 it -PRON- PRP cord-023584-yaxawqhj 29 3 is be VBZ cord-023584-yaxawqhj 29 4 true true JJ cord-023584-yaxawqhj 29 5 that that IN cord-023584-yaxawqhj 29 6 random random JJ cord-023584-yaxawqhj 29 7 screening screening NN cord-023584-yaxawqhj 29 8 still still RB cord-023584-yaxawqhj 29 9 offers offer VBZ cord-023584-yaxawqhj 29 10 the the DT cord-023584-yaxawqhj 29 11 best good JJS cord-023584-yaxawqhj 29 12 chance chance NN cord-023584-yaxawqhj 29 13 of of IN cord-023584-yaxawqhj 29 14 discovering discover VBG cord-023584-yaxawqhj 29 15 new new JJ cord-023584-yaxawqhj 29 16 drugs drug NNS cord-023584-yaxawqhj 29 17 , , , cord-023584-yaxawqhj 29 18 unless unless IN cord-023584-yaxawqhj 29 19 a a DT cord-023584-yaxawqhj 29 20 realistic realistic JJ cord-023584-yaxawqhj 29 21 appraisal appraisal NN cord-023584-yaxawqhj 29 22 of of IN cord-023584-yaxawqhj 29 23 the the DT cord-023584-yaxawqhj 29 24 whole whole JJ cord-023584-yaxawqhj 29 25 project project NN cord-023584-yaxawqhj 29 26 is be VBZ cord-023584-yaxawqhj 29 27 made make VBN cord-023584-yaxawqhj 29 28 a a DT cord-023584-yaxawqhj 29 29 t t NN cord-023584-yaxawqhj 29 30 the the DT cord-023584-yaxawqhj 29 31 outset outset NN cord-023584-yaxawqhj 29 32 , , , cord-023584-yaxawqhj 29 33 the the DT cord-023584-yaxawqhj 29 34 products product NNS cord-023584-yaxawqhj 29 35 of of IN cord-023584-yaxawqhj 29 36 random random JJ cord-023584-yaxawqhj 29 37 screens screen NNS cord-023584-yaxawqhj 29 38 could could MD cord-023584-yaxawqhj 29 39 well well RB cord-023584-yaxawqhj 29 40 be be VB cord-023584-yaxawqhj 29 41 useless useless JJ cord-023584-yaxawqhj 29 42 as as IN cord-023584-yaxawqhj 29 43 potential potential JJ cord-023584-yaxawqhj 29 44 medicines medicine NNS cord-023584-yaxawqhj 29 45 . . . cord-023584-yaxawqhj 30 1 Somr Somr NNP cord-023584-yaxawqhj 30 2 of of IN cord-023584-yaxawqhj 30 3 the the DT cord-023584-yaxawqhj 30 4 more more RBR cord-023584-yaxawqhj 30 5 important important JJ cord-023584-yaxawqhj 30 6 considcrations considcration NNS cord-023584-yaxawqhj 30 7 are be VBP cord-023584-yaxawqhj 30 8 listed list VBN cord-023584-yaxawqhj 30 9 below below RB cord-023584-yaxawqhj 30 10 . . . cord-023584-yaxawqhj 31 1 A. a. LS cord-023584-yaxawqhj 31 2 DISEASES disease NNS cord-023584-yaxawqhj 31 3 OF of IN cord-023584-yaxawqhj 31 4 ECONOMIC economic JJ cord-023584-yaxawqhj 31 5 IMPORTANCE importance NN cord-023584-yaxawqhj 32 1 I -PRON- PRP cord-023584-yaxawqhj 32 2 n n CC cord-023584-yaxawqhj 32 3 ordcr ordcr NNS cord-023584-yaxawqhj 32 4 to to IN cord-023584-yaxawqhj 32 5 he -PRON- PRP cord-023584-yaxawqhj 33 1 commercially commercially RB cord-023584-yaxawqhj 33 2 viable viable JJ cord-023584-yaxawqhj 33 3 a a DT cord-023584-yaxawqhj 33 4 drug drug NN cord-023584-yaxawqhj 33 5 must must MD cord-023584-yaxawqhj 33 6 sell sell VB cord-023584-yaxawqhj 33 7 in in IN cord-023584-yaxawqhj 33 8 sufficient sufficient JJ cord-023584-yaxawqhj 33 9 quantities quantity NNS cord-023584-yaxawqhj 33 10 to to TO cord-023584-yaxawqhj 33 11 pay pay VB cord-023584-yaxawqhj 33 12 for for IN cord-023584-yaxawqhj 33 13 its -PRON- PRP$ cord-023584-yaxawqhj 33 14 devclopmcnt devclopmcnt NN cord-023584-yaxawqhj 33 15 and and CC cord-023584-yaxawqhj 33 16 manufacture manufacture NN cord-023584-yaxawqhj 33 17 as as RB cord-023584-yaxawqhj 33 18 well well RB cord-023584-yaxawqhj 33 19 as as IN cord-023584-yaxawqhj 33 20 for for IN cord-023584-yaxawqhj 33 21 future future JJ cord-023584-yaxawqhj 33 22 research research NN cord-023584-yaxawqhj 33 23 . . . cord-023584-yaxawqhj 34 1 Because because IN cord-023584-yaxawqhj 34 2 of of IN cord-023584-yaxawqhj 34 3 this this DT cord-023584-yaxawqhj 34 4 , , , cord-023584-yaxawqhj 34 5 and and CC cord-023584-yaxawqhj 34 6 because because IN cord-023584-yaxawqhj 34 7 antiviral antiviral JJ cord-023584-yaxawqhj 34 8 chemicals chemical NNS cord-023584-yaxawqhj 34 9 tend tend VBP cord-023584-yaxawqhj 34 10 to to TO cord-023584-yaxawqhj 34 11 inhibit inhibit VB cord-023584-yaxawqhj 34 12 specific specific JJ cord-023584-yaxawqhj 34 13 viruses virus NNS cord-023584-yaxawqhj 34 14 . . . cord-023584-yaxawqhj 35 1 diseases disease NNS cord-023584-yaxawqhj 35 2 of of IN cord-023584-yaxawqhj 35 3 low low JJ cord-023584-yaxawqhj 35 4 incidence incidence NN cord-023584-yaxawqhj 35 5 or or CC cord-023584-yaxawqhj 35 6 loneconomic loneconomic JJ cord-023584-yaxawqhj 35 7 importance importance NN cord-023584-yaxawqhj 35 8 are be VBP cord-023584-yaxawqhj 35 9 ruled rule VBN cord-023584-yaxawqhj 35 10 out out RP cord-023584-yaxawqhj 35 11 as as IN cord-023584-yaxawqhj 35 12 primary primary JJ cord-023584-yaxawqhj 35 13 targets target NNS cord-023584-yaxawqhj 35 14 for for IN cord-023584-yaxawqhj 35 15 drug drug NN cord-023584-yaxawqhj 35 16 devclopment devclopment NN cord-023584-yaxawqhj 35 17 . . . cord-023584-yaxawqhj 36 1 This this DT cord-023584-yaxawqhj 36 2 may may MD cord-023584-yaxawqhj 36 3 seem seem VB cord-023584-yaxawqhj 36 4 inhumane inhumane JJ cord-023584-yaxawqhj 36 5 , , , cord-023584-yaxawqhj 36 6 particularly particularly RB cord-023584-yaxawqhj 36 7 in in IN cord-023584-yaxawqhj 36 8 the the DT cord-023584-yaxawqhj 36 9 field field NN cord-023584-yaxawqhj 36 10 of of IN cord-023584-yaxawqhj 36 11 human human JJ cord-023584-yaxawqhj 36 12 virus virus NN cord-023584-yaxawqhj 36 13 diseases disease NNS cord-023584-yaxawqhj 36 14 , , , cord-023584-yaxawqhj 36 15 but but CC cord-023584-yaxawqhj 36 16 the the DT cord-023584-yaxawqhj 36 17 fact fact NN cord-023584-yaxawqhj 36 18 remains remain VBZ cord-023584-yaxawqhj 36 19 that that IN cord-023584-yaxawqhj 36 20 it -PRON- PRP cord-023584-yaxawqhj 36 21 is be VBZ cord-023584-yaxawqhj 36 22 no no RB cord-023584-yaxawqhj 36 23 easier easy JJR cord-023584-yaxawqhj 36 24 to to TO cord-023584-yaxawqhj 36 25 find find VB cord-023584-yaxawqhj 36 26 a a DT cord-023584-yaxawqhj 36 27 drug drug NN cord-023584-yaxawqhj 36 28 against against IN cord-023584-yaxawqhj 36 29 rabies rabie NNS cord-023584-yaxawqhj 36 30 than than IN cord-023584-yaxawqhj 36 31 against against IN cord-023584-yaxawqhj 36 32 influenza influenza NN cord-023584-yaxawqhj 36 33 , , , cord-023584-yaxawqhj 36 34 and and CC cord-023584-yaxawqhj 36 35 the the DT cord-023584-yaxawqhj 36 36 sales sale NNS cord-023584-yaxawqhj 36 37 from from IN cord-023584-yaxawqhj 36 38 a a DT cord-023584-yaxawqhj 36 39 specific specific JJ cord-023584-yaxawqhj 36 40 antirabies antirabie NNS cord-023584-yaxawqhj 36 41 drug drug NN cord-023584-yaxawqhj 36 42 would would MD cord-023584-yaxawqhj 36 43 never never RB cord-023584-yaxawqhj 36 44 cover cover VB cord-023584-yaxawqhj 36 45 its -PRON- PRP$ cord-023584-yaxawqhj 36 46 own own JJ cord-023584-yaxawqhj 36 47 developmrnt developmrnt NNS cord-023584-yaxawqhj 36 48 costs cost NNS cord-023584-yaxawqhj 36 49 . . . cord-023584-yaxawqhj 37 1 Diseases disease NNS cord-023584-yaxawqhj 37 2 of of IN cord-023584-yaxawqhj 37 3 loiv loiv NNS cord-023584-yaxawqhj 37 4 incidence incidence NN cord-023584-yaxawqhj 37 5 or or CC cord-023584-yaxawqhj 37 6 low low JJ cord-023584-yaxawqhj 37 7 cconomic cconomic JJ cord-023584-yaxawqhj 37 8 importance importance NN cord-023584-yaxawqhj 37 9 , , , cord-023584-yaxawqhj 38 1 no no RB cord-023584-yaxawqhj 38 2 matter matter RB cord-023584-yaxawqhj 38 3 how how WRB cord-023584-yaxawqhj 38 4 serious serious JJ cord-023584-yaxawqhj 38 5 the the DT cord-023584-yaxawqhj 38 6 outcome outcome NN cord-023584-yaxawqhj 38 7 may may MD cord-023584-yaxawqhj 38 8 be be VB cord-023584-yaxawqhj 38 9 for for IN cord-023584-yaxawqhj 38 10 the the DT cord-023584-yaxawqhj 38 11 infected infected JJ cord-023584-yaxawqhj 38 12 individual individual NN cord-023584-yaxawqhj 38 13 , , , cord-023584-yaxawqhj 38 14 inevitably inevitably RB cord-023584-yaxawqhj 38 15 must must MD cord-023584-yaxawqhj 38 16 remain remain VB cord-023584-yaxawqhj 38 17 the the DT cord-023584-yaxawqhj 38 18 subjects subject NNS cord-023584-yaxawqhj 38 19 of of IN cord-023584-yaxawqhj 38 20 sponsored sponsor VBN cord-023584-yaxawqhj 38 21 research research NN cord-023584-yaxawqhj 38 22 . . . cord-023584-yaxawqhj 39 1 Nevertheless nevertheless RB cord-023584-yaxawqhj 39 2 , , , cord-023584-yaxawqhj 39 3 treatments treatment NNS cord-023584-yaxawqhj 39 4 for for IN cord-023584-yaxawqhj 39 5 some some DT cord-023584-yaxawqhj 39 6 of of IN cord-023584-yaxawqhj 39 7 these these DT cord-023584-yaxawqhj 39 8 diseases disease NNS cord-023584-yaxawqhj 39 9 may may MD cord-023584-yaxawqhj 39 10 emerge emerge VB cord-023584-yaxawqhj 39 11 as as IN cord-023584-yaxawqhj 39 12 drugs drug NNS cord-023584-yaxawqhj 39 13 are be VBP cord-023584-yaxawqhj 39 14 developed develop VBN cord-023584-yaxawqhj 39 15 against against IN cord-023584-yaxawqhj 39 16 major major JJ cord-023584-yaxawqhj 39 17 diseases disease NNS cord-023584-yaxawqhj 39 18 . . . cord-023584-yaxawqhj 40 1 B. B. NNP cord-023584-yaxawqhj 40 2 IMMUNOLOGICAL immunological JJ cord-023584-yaxawqhj 40 3 CONTROL control NN cord-023584-yaxawqhj 41 1 Many many JJ cord-023584-yaxawqhj 41 2 virus virus NN cord-023584-yaxawqhj 41 3 diseases disease NNS cord-023584-yaxawqhj 41 4 , , , cord-023584-yaxawqhj 41 5 both both DT cord-023584-yaxawqhj 41 6 of of IN cord-023584-yaxawqhj 41 7 humans human NNS cord-023584-yaxawqhj 41 8 and and CC cord-023584-yaxawqhj 41 9 animals animal NNS cord-023584-yaxawqhj 41 10 , , , cord-023584-yaxawqhj 41 11 have have VBP cord-023584-yaxawqhj 41 12 been be VBN cord-023584-yaxawqhj 41 13 successfully successfully RB cord-023584-yaxawqhj 41 14 controlled control VBN cord-023584-yaxawqhj 41 15 by by IN cord-023584-yaxawqhj 41 16 vaccines vaccine NNS cord-023584-yaxawqhj 41 17 . . . cord-023584-yaxawqhj 42 1 These these DT cord-023584-yaxawqhj 42 2 successes success NNS cord-023584-yaxawqhj 42 3 have have VBP cord-023584-yaxawqhj 42 4 naturally naturally RB cord-023584-yaxawqhj 42 5 led lead VBN cord-023584-yaxawqhj 42 6 to to IN cord-023584-yaxawqhj 42 7 improvements improvement NNS cord-023584-yaxawqhj 42 8 in in IN cord-023584-yaxawqhj 42 9 the the DT cord-023584-yaxawqhj 42 10 spectrum spectrum NN cord-023584-yaxawqhj 42 11 and and CC cord-023584-yaxawqhj 42 12 duration duration NN cord-023584-yaxawqhj 42 13 of of IN cord-023584-yaxawqhj 42 14 protection protection NN cord-023584-yaxawqhj 42 15 offered offer VBN cord-023584-yaxawqhj 42 16 by by IN cord-023584-yaxawqhj 42 17 vaccines vaccine NNS cord-023584-yaxawqhj 42 18 until until IN cord-023584-yaxawqhj 42 19 , , , cord-023584-yaxawqhj 42 20 today today NN cord-023584-yaxawqhj 42 21 , , , cord-023584-yaxawqhj 42 22 it -PRON- PRP cord-023584-yaxawqhj 42 23 is be VBZ cord-023584-yaxawqhj 42 24 difficult difficult JJ cord-023584-yaxawqhj 42 25 to to TO cord-023584-yaxawqhj 42 26 see see VB cord-023584-yaxawqhj 42 27 how how WRB cord-023584-yaxawqhj 42 28 antiviral antiviral JJ cord-023584-yaxawqhj 42 29 drugs drug NNS cord-023584-yaxawqhj 42 30 could could MD cord-023584-yaxawqhj 42 31 compete compete VB cord-023584-yaxawqhj 42 32 with with IN cord-023584-yaxawqhj 42 33 vaccines vaccine NNS cord-023584-yaxawqhj 42 34 in in IN cord-023584-yaxawqhj 42 35 the the DT cord-023584-yaxawqhj 42 36 control control NN cord-023584-yaxawqhj 42 37 of of IN cord-023584-yaxawqhj 42 38 many many JJ cord-023584-yaxawqhj 42 39 virus virus NN cord-023584-yaxawqhj 42 40 diseases disease NNS cord-023584-yaxawqhj 42 41 . . . cord-023584-yaxawqhj 43 1 As as IN cord-023584-yaxawqhj 43 2 examples example NNS cord-023584-yaxawqhj 43 3 one one PRP cord-023584-yaxawqhj 43 4 may may MD cord-023584-yaxawqhj 43 5 cite cite VB cord-023584-yaxawqhj 43 6 smallpox smallpox NN cord-023584-yaxawqhj 43 7 , , , cord-023584-yaxawqhj 43 8 yellow yellow JJ cord-023584-yaxawqhj 43 9 fever fever NN cord-023584-yaxawqhj 43 10 , , , cord-023584-yaxawqhj 43 11 polio polio NN cord-023584-yaxawqhj 43 12 , , , cord-023584-yaxawqhj 43 13 and and CC cord-023584-yaxawqhj 43 14 , , , cord-023584-yaxawqhj 43 15 more more RBR cord-023584-yaxawqhj 43 16 recently recently RB cord-023584-yaxawqhj 43 17 , , , cord-023584-yaxawqhj 43 18 measles measle NNS cord-023584-yaxawqhj 43 19 among among IN cord-023584-yaxawqhj 43 20 human human JJ cord-023584-yaxawqhj 43 21 diseases disease NNS cord-023584-yaxawqhj 43 22 , , , cord-023584-yaxawqhj 43 23 and and CC cord-023584-yaxawqhj 43 24 Newcastle Newcastle NNP cord-023584-yaxawqhj 43 25 disease disease NN cord-023584-yaxawqhj 43 26 , , , cord-023584-yaxawqhj 43 27 Marek Marek NNP cord-023584-yaxawqhj 43 28 's 's POS cord-023584-yaxawqhj 43 29 disease disease NN cord-023584-yaxawqhj 43 30 , , , cord-023584-yaxawqhj 43 31 and and CC cord-023584-yaxawqhj 43 32 infectious infectious JJ cord-023584-yaxawqhj 43 33 bronchitis bronchitis NN cord-023584-yaxawqhj 43 34 among among IN cord-023584-yaxawqhj 43 35 poultry poultry NN cord-023584-yaxawqhj 43 36 diseases disease NNS cord-023584-yaxawqhj 43 37 - - : cord-023584-yaxawqhj 43 38 an an DT cord-023584-yaxawqhj 43 39 area area NN cord-023584-yaxawqhj 43 40 of of IN cord-023584-yaxawqhj 43 41 veterinary veterinary JJ cord-023584-yaxawqhj 43 42 disease disease NN cord-023584-yaxawqhj 43 43 control control NN cord-023584-yaxawqhj 43 44 where where WRB cord-023584-yaxawqhj 43 45 vaccines vaccine NNS cord-023584-yaxawqhj 43 46 have have VBP cord-023584-yaxawqhj 43 47 been be VBN cord-023584-yaxawqhj 43 48 particularly particularly RB cord-023584-yaxawqhj 43 49 important important JJ cord-023584-yaxawqhj 43 50 . . . cord-023584-yaxawqhj 44 1 Despite despite IN cord-023584-yaxawqhj 44 2 these these DT cord-023584-yaxawqhj 44 3 triumphs triumph NNS cord-023584-yaxawqhj 44 4 , , , cord-023584-yaxawqhj 44 5 vaccines vaccine NNS cord-023584-yaxawqhj 44 6 are be VBP cord-023584-yaxawqhj 44 7 not not RB cord-023584-yaxawqhj 44 8 , , , cord-023584-yaxawqhj 44 9 and and CC cord-023584-yaxawqhj 44 10 probably probably RB cord-023584-yaxawqhj 44 11 never never RB cord-023584-yaxawqhj 44 12 will will MD cord-023584-yaxawqhj 44 13 be be VB cord-023584-yaxawqhj 44 14 , , , cord-023584-yaxawqhj 44 15 the the DT cord-023584-yaxawqhj 44 16 complete complete JJ cord-023584-yaxawqhj 44 17 answer answer NN cord-023584-yaxawqhj 44 18 to to IN cord-023584-yaxawqhj 44 19 the the DT cord-023584-yaxawqhj 44 20 control control NN cord-023584-yaxawqhj 44 21 of of IN cord-023584-yaxawqhj 44 22 certain certain JJ cord-023584-yaxawqhj 44 23 virus virus NN cord-023584-yaxawqhj 44 24 diseases disease NNS cord-023584-yaxawqhj 44 25 . . . cord-023584-yaxawqhj 45 1 It -PRON- PRP cord-023584-yaxawqhj 45 2 is be VBZ cord-023584-yaxawqhj 45 3 in in IN cord-023584-yaxawqhj 45 4 these these DT cord-023584-yaxawqhj 45 5 areas area NNS cord-023584-yaxawqhj 45 6 where where WRB cord-023584-yaxawqhj 45 7 drugs drug NNS cord-023584-yaxawqhj 45 8 would would MD cord-023584-yaxawqhj 45 9 be be VB cord-023584-yaxawqhj 45 10 useful useful JJ cord-023584-yaxawqhj 45 11 , , , cord-023584-yaxawqhj 45 12 and and CC cord-023584-yaxawqhj 45 13 it -PRON- PRP cord-023584-yaxawqhj 45 14 is be VBZ cord-023584-yaxawqhj 45 15 on on IN cord-023584-yaxawqhj 45 16 these these DT cord-023584-yaxawqhj 45 17 diseases disease NNS cord-023584-yaxawqhj 45 18 that that WDT cord-023584-yaxawqhj 45 19 efforts effort NNS cord-023584-yaxawqhj 45 20 should should MD cord-023584-yaxawqhj 45 21 be be VB cord-023584-yaxawqhj 45 22 concentrated concentrate VBN cord-023584-yaxawqhj 45 23 . . . cord-023584-yaxawqhj 46 1 The the DT cord-023584-yaxawqhj 46 2 two two CD cord-023584-yaxawqhj 46 3 most most RBS cord-023584-yaxawqhj 46 4 important important JJ cord-023584-yaxawqhj 46 5 human human JJ cord-023584-yaxawqhj 46 6 diseases disease NNS cord-023584-yaxawqhj 46 7 in in IN cord-023584-yaxawqhj 46 8 this this DT cord-023584-yaxawqhj 46 9 class class NN cord-023584-yaxawqhj 46 10 are be VBP cord-023584-yaxawqhj 46 11 influenza influenza JJ cord-023584-yaxawqhj 46 12 and and CC cord-023584-yaxawqhj 46 13 the the DT cord-023584-yaxawqhj 46 14 common common JJ cord-023584-yaxawqhj 46 15 cold cold NN cord-023584-yaxawqhj 46 16 . . . cord-023584-yaxawqhj 47 1 When when WRB cord-023584-yaxawqhj 47 2 a a DT cord-023584-yaxawqhj 47 3 novel novel JJ cord-023584-yaxawqhj 47 4 strain strain NN cord-023584-yaxawqhj 47 5 of of IN cord-023584-yaxawqhj 47 6 influenza influenza NN cord-023584-yaxawqhj 47 7 appears appear VBZ cord-023584-yaxawqhj 47 8 among among IN cord-023584-yaxawqhj 47 9 the the DT cord-023584-yaxawqhj 47 10 human human JJ cord-023584-yaxawqhj 47 11 population population NN cord-023584-yaxawqhj 47 12 , , , cord-023584-yaxawqhj 47 13 as as IN cord-023584-yaxawqhj 47 14 happened happen VBN cord-023584-yaxawqhj 47 15 in in IN cord-023584-yaxawqhj 47 16 1933 1933 CD cord-023584-yaxawqhj 47 17 , , , cord-023584-yaxawqhj 47 18 1947 1947 CD cord-023584-yaxawqhj 47 19 , , , cord-023584-yaxawqhj 47 20 and and CC cord-023584-yaxawqhj 47 21 1956 1956 CD cord-023584-yaxawqhj 47 22 , , , cord-023584-yaxawqhj 47 23 existing exist VBG cord-023584-yaxawqhj 47 24 immunity immunity NN cord-023584-yaxawqhj 47 25 to to IN cord-023584-yaxawqhj 47 26 the the DT cord-023584-yaxawqhj 47 27 previous previous JJ cord-023584-yaxawqhj 47 28 current current JJ cord-023584-yaxawqhj 47 29 influenza influenza NN cord-023584-yaxawqhj 47 30 strain strain NN cord-023584-yaxawqhj 47 31 is be VBZ cord-023584-yaxawqhj 47 32 not not RB cord-023584-yaxawqhj 47 33 effective effective JJ cord-023584-yaxawqhj 47 34 , , , cord-023584-yaxawqhj 47 35 and and CC cord-023584-yaxawqhj 47 36 widespread widespread JJ cord-023584-yaxawqhj 47 37 epidemics epidemic NNS cord-023584-yaxawqhj 47 38 of of IN cord-023584-yaxawqhj 47 39 disease disease NN cord-023584-yaxawqhj 47 40 occur occur VBP cord-023584-yaxawqhj 47 41 . . . cord-023584-yaxawqhj 48 1 The the DT cord-023584-yaxawqhj 48 2 disease disease NN cord-023584-yaxawqhj 48 3 spreads spread VBZ cord-023584-yaxawqhj 48 4 so so RB cord-023584-yaxawqhj 48 5 rapidly rapidly RB cord-023584-yaxawqhj 48 6 after after IN cord-023584-yaxawqhj 48 7 it -PRON- PRP cord-023584-yaxawqhj 48 8 first first RB cord-023584-yaxawqhj 48 9 appears appear VBZ cord-023584-yaxawqhj 48 10 that that IN cord-023584-yaxawqhj 48 11 it -PRON- PRP cord-023584-yaxawqhj 48 12 is be VBZ cord-023584-yaxawqhj 48 13 not not RB cord-023584-yaxawqhj 48 14 possible possible JJ cord-023584-yaxawqhj 48 15 to to TO cord-023584-yaxawqhj 48 16 develop develop VB cord-023584-yaxawqhj 48 17 , , , cord-023584-yaxawqhj 48 18 distribute distribute VB cord-023584-yaxawqhj 48 19 , , , cord-023584-yaxawqhj 48 20 and and CC cord-023584-yaxawqhj 48 21 administer administer VB cord-023584-yaxawqhj 48 22 a a DT cord-023584-yaxawqhj 48 23 vaccine vaccine NN cord-023584-yaxawqhj 48 24 based base VBN cord-023584-yaxawqhj 48 25 on on IN cord-023584-yaxawqhj 48 26 the the DT cord-023584-yaxawqhj 48 27 new new JJ cord-023584-yaxawqhj 48 28 strain strain NN cord-023584-yaxawqhj 48 29 soon soon RB cord-023584-yaxawqhj 48 30 enough enough RB cord-023584-yaxawqhj 48 31 to to TO cord-023584-yaxawqhj 48 32 protect protect VB cord-023584-yaxawqhj 48 33 useful useful JJ cord-023584-yaxawqhj 48 34 numbers number NNS cord-023584-yaxawqhj 48 35 of of IN cord-023584-yaxawqhj 48 36 the the DT cord-023584-yaxawqhj 48 37 population population NN cord-023584-yaxawqhj 48 38 . . . cord-023584-yaxawqhj 49 1 Even even RB cord-023584-yaxawqhj 49 2 after after IN cord-023584-yaxawqhj 49 3 the the DT cord-023584-yaxawqhj 49 4 initial initial JJ cord-023584-yaxawqhj 49 5 overwhelming overwhelming JJ cord-023584-yaxawqhj 49 6 pandemic pandemic NN cord-023584-yaxawqhj 49 7 , , , cord-023584-yaxawqhj 49 8 successive successive JJ cord-023584-yaxawqhj 49 9 epidemics epidemic NNS cord-023584-yaxawqhj 49 10 will will MD cord-023584-yaxawqhj 49 11 occur occur VB cord-023584-yaxawqhj 49 12 as as IN cord-023584-yaxawqhj 49 13 the the DT cord-023584-yaxawqhj 49 14 disease disease NN cord-023584-yaxawqhj 49 15 penetrates penetrate VBZ cord-023584-yaxawqhj 49 16 into into IN cord-023584-yaxawqhj 49 17 pockets pocket NNS cord-023584-yaxawqhj 49 18 of of IN cord-023584-yaxawqhj 49 19 the the DT cord-023584-yaxawqhj 49 20 community community NN cord-023584-yaxawqhj 49 21 that that WDT cord-023584-yaxawqhj 49 22 ' ' '' cord-023584-yaxawqhj 49 23 had have VBD cord-023584-yaxawqhj 49 24 escaped escape VBN cord-023584-yaxawqhj 49 25 infection infection NN cord-023584-yaxawqhj 49 26 . . . cord-023584-yaxawqhj 50 1 The the DT cord-023584-yaxawqhj 50 2 disease disease NN cord-023584-yaxawqhj 50 3 is be VBZ cord-023584-yaxawqhj 50 4 then then RB cord-023584-yaxawqhj 50 5 maintained maintain VBN cord-023584-yaxawqhj 50 6 partly partly RB cord-023584-yaxawqhj 50 7 by by IN cord-023584-yaxawqhj 50 8 the the DT cord-023584-yaxawqhj 50 9 continuing continue VBG cord-023584-yaxawqhj 50 10 appearance appearance NN cord-023584-yaxawqhj 50 11 of of IN cord-023584-yaxawqhj 50 12 susceptible susceptible JJ cord-023584-yaxawqhj 50 13 juveniles juvenile NNS cord-023584-yaxawqhj 50 14 , , , cord-023584-yaxawqhj 50 15 partly partly RB cord-023584-yaxawqhj 50 16 by by IN cord-023584-yaxawqhj 50 17 spontaneous spontaneous JJ cord-023584-yaxawqhj 50 18 antigenic antigenic JJ cord-023584-yaxawqhj 50 19 modifications modification NNS cord-023584-yaxawqhj 50 20 in in IN cord-023584-yaxawqhj 50 21 the the DT cord-023584-yaxawqhj 50 22 virus virus NN cord-023584-yaxawqhj 50 23 enabling enable VBG cord-023584-yaxawqhj 50 24 it -PRON- PRP cord-023584-yaxawqhj 50 25 to to TO cord-023584-yaxawqhj 50 26 overcome overcome VB cord-023584-yaxawqhj 50 27 previous previous JJ cord-023584-yaxawqhj 50 28 immunity immunity NN cord-023584-yaxawqhj 50 29 , , , cord-023584-yaxawqhj 50 30 and and CC cord-023584-yaxawqhj 50 31 partly partly RB cord-023584-yaxawqhj 50 32 by by IN cord-023584-yaxawqhj 50 33 the the DT cord-023584-yaxawqhj 50 34 general general JJ cord-023584-yaxawqhj 50 35 decline decline NN cord-023584-yaxawqhj 50 36 in in IN cord-023584-yaxawqhj 50 37 immunity immunity NN cord-023584-yaxawqhj 50 38 of of IN cord-023584-yaxawqhj 50 39 other other JJ cord-023584-yaxawqhj 50 40 individuals individual NNS cord-023584-yaxawqhj 50 41 with with IN cord-023584-yaxawqhj 50 42 the the DT cord-023584-yaxawqhj 50 43 passage passage NN cord-023584-yaxawqhj 50 44 of of IN cord-023584-yaxawqhj 50 45 time time NN cord-023584-yaxawqhj 50 46 . . . cord-023584-yaxawqhj 51 1 After after IN cord-023584-yaxawqhj 51 2 the the DT cord-023584-yaxawqhj 51 3 initial initial JJ cord-023584-yaxawqhj 51 4 pandemic pandemic NN cord-023584-yaxawqhj 51 5 , , , cord-023584-yaxawqhj 51 6 it -PRON- PRP cord-023584-yaxawqhj 51 7 is be VBZ cord-023584-yaxawqhj 51 8 theoretically theoretically RB cord-023584-yaxawqhj 51 9 possible possible JJ cord-023584-yaxawqhj 51 10 to to TO cord-023584-yaxawqhj 51 11 control control VB cord-023584-yaxawqhj 51 12 the the DT cord-023584-yaxawqhj 51 13 disease disease NN cord-023584-yaxawqhj 51 14 with with IN cord-023584-yaxawqhj 51 15 widespread widespread JJ cord-023584-yaxawqhj 51 16 vaccination vaccination NN cord-023584-yaxawqhj 51 17 , , , cord-023584-yaxawqhj 51 18 but but CC cord-023584-yaxawqhj 51 19 in in IN cord-023584-yaxawqhj 51 20 practice practice NN cord-023584-yaxawqhj 51 21 this this DT cord-023584-yaxawqhj 51 22 is be VBZ cord-023584-yaxawqhj 51 23 not not RB cord-023584-yaxawqhj 51 24 done do VBN cord-023584-yaxawqhj 51 25 . . . cord-023584-yaxawqhj 52 1 Consequently consequently RB cord-023584-yaxawqhj 52 2 the the DT cord-023584-yaxawqhj 52 3 disease disease NN cord-023584-yaxawqhj 52 4 smoulders smoulder VBZ cord-023584-yaxawqhj 52 5 on on RP cord-023584-yaxawqhj 52 6 in in IN cord-023584-yaxawqhj 52 7 the the DT cord-023584-yaxawqhj 52 8 community community NN cord-023584-yaxawqhj 52 9 , , , cord-023584-yaxawqhj 52 10 appearing appear VBG cord-023584-yaxawqhj 52 11 as as IN cord-023584-yaxawqhj 52 12 isolated isolate VBN cord-023584-yaxawqhj 52 13 cases case NNS cord-023584-yaxawqhj 52 14 and and CC cord-023584-yaxawqhj 52 15 occasional occasional JJ cord-023584-yaxawqhj 52 16 outbreaks outbreak NNS cord-023584-yaxawqhj 52 17 and and CC cord-023584-yaxawqhj 52 18 epidemics epidemic NNS cord-023584-yaxawqhj 52 19 . . . cord-023584-yaxawqhj 53 1 These these DT cord-023584-yaxawqhj 53 2 are be VBP cord-023584-yaxawqhj 53 3 the the DT cord-023584-yaxawqhj 53 4 conditions condition NNS cord-023584-yaxawqhj 53 5 under under IN cord-023584-yaxawqhj 53 6 which which WDT cord-023584-yaxawqhj 53 7 the the DT cord-023584-yaxawqhj 53 8 disease disease NN cord-023584-yaxawqhj 53 9 normally normally RB cord-023584-yaxawqhj 53 10 exists exist VBZ cord-023584-yaxawqhj 53 11 , , , cord-023584-yaxawqhj 53 12 and and CC cord-023584-yaxawqhj 53 13 it -PRON- PRP cord-023584-yaxawqhj 53 14 is be VBZ cord-023584-yaxawqhj 53 15 this this DT cord-023584-yaxawqhj 53 16 situation situation NN cord-023584-yaxawqhj 53 17 , , , cord-023584-yaxawqhj 53 18 rather rather RB cord-023584-yaxawqhj 53 19 than than IN cord-023584-yaxawqhj 53 20 the the DT cord-023584-yaxawqhj 53 21 much much JJ cord-023584-yaxawqhj 53 22 publicized publicize VBN cord-023584-yaxawqhj 53 23 pandemics pandemic NNS cord-023584-yaxawqhj 53 24 , , , cord-023584-yaxawqhj 53 25 which which WDT cord-023584-yaxawqhj 53 26 causes cause VBZ cord-023584-yaxawqhj 53 27 the the DT cord-023584-yaxawqhj 53 28 greatest great JJS cord-023584-yaxawqhj 53 29 economic economic JJ cord-023584-yaxawqhj 53 30 loss loss NN cord-023584-yaxawqhj 53 31 to to IN cord-023584-yaxawqhj 53 32 industrialized industrialize VBN cord-023584-yaxawqhj 53 33 countries country NNS cord-023584-yaxawqhj 53 34 . . . cord-023584-yaxawqhj 54 1 The the DT cord-023584-yaxawqhj 54 2 overall overall JJ cord-023584-yaxawqhj 54 3 loss loss NN cord-023584-yaxawqhj 54 4 in in IN cord-023584-yaxawqhj 54 5 1956 1956 CD cord-023584-yaxawqhj 54 6 - - SYM cord-023584-yaxawqhj 54 7 1957 1957 CD cord-023584-yaxawqhj 54 8 in in IN cord-023584-yaxawqhj 54 9 Great Great NNP cord-023584-yaxawqhj 54 10 Britain Britain NNP cord-023584-yaxawqhj 54 11 due due IN cord-023584-yaxawqhj 54 12 to to IN cord-023584-yaxawqhj 54 13 the the DT cord-023584-yaxawqhj 54 14 Asian asian JJ cord-023584-yaxawqhj 54 15 influenza influenza NN cord-023584-yaxawqhj 54 16 pandemic pandemic NN cord-023584-yaxawqhj 54 17 was be VBD cord-023584-yaxawqhj 54 18 estimated estimate VBN cord-023584-yaxawqhj 54 19 at at IN cord-023584-yaxawqhj 54 20 X100 x100 CD cord-023584-yaxawqhj 54 21 million million CD cord-023584-yaxawqhj 54 22 , , , cord-023584-yaxawqhj 54 23 but but CC cord-023584-yaxawqhj 54 24 the the DT cord-023584-yaxawqhj 54 25 continuing continue VBG cord-023584-yaxawqhj 54 26 loss loss NN cord-023584-yaxawqhj 54 27 , , , cord-023584-yaxawqhj 54 28 from from IN cord-023584-yaxawqhj 54 29 that that DT cord-023584-yaxawqhj 54 30 time time NN cord-023584-yaxawqhj 54 31 on on IN cord-023584-yaxawqhj 54 32 has have VBZ cord-023584-yaxawqhj 54 33 been be VBN cord-023584-yaxawqhj 54 34 at at IN cord-023584-yaxawqhj 54 35 least least JJS cord-023584-yaxawqhj 54 36 X30 x30 JJ cord-023584-yaxawqhj 54 37 million million CD cord-023584-yaxawqhj 54 38 each each DT cord-023584-yaxawqhj 54 39 year year NN cord-023584-yaxawqhj 54 40 . . . cord-023584-yaxawqhj 55 1 Losses loss NNS cord-023584-yaxawqhj 55 2 in in IN cord-023584-yaxawqhj 55 3 Europe Europe NNP cord-023584-yaxawqhj 55 4 , , , cord-023584-yaxawqhj 55 5 North North NNP cord-023584-yaxawqhj 55 6 America America NNP cord-023584-yaxawqhj 55 7 , , , cord-023584-yaxawqhj 55 8 Japan Japan NNP cord-023584-yaxawqhj 55 9 , , , cord-023584-yaxawqhj 55 10 and and CC cord-023584-yaxawqhj 55 11 similar similar JJ cord-023584-yaxawqhj 55 12 industrialized industrialize VBN cord-023584-yaxawqhj 55 13 communities community NNS cord-023584-yaxawqhj 55 14 must must MD cord-023584-yaxawqhj 55 15 be be VB cord-023584-yaxawqhj 55 16 romparablr romparablr NNS cord-023584-yaxawqhj 55 17 , , , cord-023584-yaxawqhj 55 18 and and CC cord-023584-yaxawqhj 55 19 if if IN cord-023584-yaxawqhj 55 20 only only RB cord-023584-yaxawqhj 55 21 a a DT cord-023584-yaxawqhj 55 22 fraction fraction NN cord-023584-yaxawqhj 55 23 of of IN cord-023584-yaxawqhj 55 24 the the DT cord-023584-yaxawqhj 55 25 disease disease NN cord-023584-yaxawqhj 55 26 could could MD cord-023584-yaxawqhj 55 27 be be VB cord-023584-yaxawqhj 55 28 prevented prevent VBN cord-023584-yaxawqhj 55 29 by by IN cord-023584-yaxawqhj 55 30 a a DT cord-023584-yaxawqhj 55 31 drug drug NN cord-023584-yaxawqhj 55 32 , , , cord-023584-yaxawqhj 55 33 the the DT cord-023584-yaxawqhj 55 34 economic economic JJ cord-023584-yaxawqhj 55 35 benefits benefit NNS cord-023584-yaxawqhj 55 36 would would MD cord-023584-yaxawqhj 55 37 be be VB cord-023584-yaxawqhj 55 38 enormous enormous JJ cord-023584-yaxawqhj 55 39 . . . cord-023584-yaxawqhj 56 1 Losses loss NNS cord-023584-yaxawqhj 56 2 due due JJ cord-023584-yaxawqhj 56 3 to to IN cord-023584-yaxawqhj 56 4 the the DT cord-023584-yaxawqhj 56 5 common common JJ cord-023584-yaxawqhj 56 6 cold cold NN cord-023584-yaxawqhj 56 7 are be VBP cord-023584-yaxawqhj 56 8 comparable comparable JJ cord-023584-yaxawqhj 56 9 . . . cord-023584-yaxawqhj 57 1 The the DT cord-023584-yaxawqhj 57 2 careful careful JJ cord-023584-yaxawqhj 57 3 study study NN cord-023584-yaxawqhj 57 4 of of IN cord-023584-yaxawqhj 57 5 Lidwell Lidwell NNP cord-023584-yaxawqhj 57 6 and and CC cord-023584-yaxawqhj 57 7 Williams Williams NNP cord-023584-yaxawqhj 57 8 ( ( -LRB- cord-023584-yaxawqhj 57 9 1961 1961 CD cord-023584-yaxawqhj 57 10 ) ) -RRB- cord-023584-yaxawqhj 57 11 showed show VBD cord-023584-yaxawqhj 57 12 that that IN cord-023584-yaxawqhj 57 13 approximately approximately RB cord-023584-yaxawqhj 57 14 11 11 CD cord-023584-yaxawqhj 57 15 X x NN cord-023584-yaxawqhj 57 16 lo6 lo6 NNS cord-023584-yaxawqhj 57 17 working working NN cord-023584-yaxawqhj 57 18 days day NNS cord-023584-yaxawqhj 57 19 arc arc NNP cord-023584-yaxawqhj 57 20 lost lose VBD cord-023584-yaxawqhj 57 21 cach cach NNP cord-023584-yaxawqhj 57 22 year year NN cord-023584-yaxawqhj 57 23 in in IN cord-023584-yaxawqhj 57 24 Great Great NNP cord-023584-yaxawqhj 57 25 Britain Britain NNP cord-023584-yaxawqhj 57 26 alone alone RB cord-023584-yaxawqhj 57 27 from from IN cord-023584-yaxawqhj 57 28 the the DT cord-023584-yaxawqhj 57 29 common common JJ cord-023584-yaxawqhj 57 30 cold cold NN cord-023584-yaxawqhj 57 31 . . . cord-023584-yaxawqhj 58 1 Scvertheless Scvertheless NNP cord-023584-yaxawqhj 58 2 , , , cord-023584-yaxawqhj 58 3 the the DT cord-023584-yaxawqhj 58 4 prospects prospect NNS cord-023584-yaxawqhj 58 5 for for IN cord-023584-yaxawqhj 58 6 a a DT cord-023584-yaxawqhj 58 7 common common JJ cord-023584-yaxawqhj 58 8 cold cold JJ cord-023584-yaxawqhj 58 9 vaccine vaccine NN cord-023584-yaxawqhj 58 10 are be VBP cord-023584-yaxawqhj 58 11 poor poor JJ cord-023584-yaxawqhj 58 12 because because IN cord-023584-yaxawqhj 58 13 of of IN cord-023584-yaxawqhj 58 14 the the DT cord-023584-yaxawqhj 58 15 large large JJ cord-023584-yaxawqhj 58 16 number number NN cord-023584-yaxawqhj 58 17 of of IN cord-023584-yaxawqhj 58 18 viruses virus NNS cord-023584-yaxawqhj 58 19 which which WDT cord-023584-yaxawqhj 58 20 are be VBP cord-023584-yaxawqhj 58 21 known know VBN cord-023584-yaxawqhj 58 22 to to TO cord-023584-yaxawqhj 58 23 cause cause VB cord-023584-yaxawqhj 58 24 the the DT cord-023584-yaxawqhj 58 25 disease disease NN cord-023584-yaxawqhj 58 26 . . . cord-023584-yaxawqhj 59 1 There there EX cord-023584-yaxawqhj 59 2 are be VBP cord-023584-yaxawqhj 59 3 89 89 CD cord-023584-yaxawqhj 59 4 known know VBN cord-023584-yaxawqhj 59 5 rhinoviruses rhinovirus NNS cord-023584-yaxawqhj 59 6 ( ( -LRB- cord-023584-yaxawqhj 59 7 Kapikian Kapikian NNP cord-023584-yaxawqhj 59 8 , , , cord-023584-yaxawqhj 59 9 1971 1971 CD cord-023584-yaxawqhj 59 10 ) ) -RRB- cord-023584-yaxawqhj 59 11 , , , cord-023584-yaxawqhj 59 12 probably probably RB cord-023584-yaxawqhj 59 13 a a DT cord-023584-yaxawqhj 59 14 comparable comparable JJ cord-023584-yaxawqhj 59 15 number number NN cord-023584-yaxawqhj 59 16 of of IN cord-023584-yaxawqhj 59 17 as as IN cord-023584-yaxawqhj 59 18 yct yct FW cord-023584-yaxawqhj 59 19 unclassified unclassified JJ cord-023584-yaxawqhj 59 20 rhinoviruses rhinoviruses NNPS cord-023584-yaxawqhj 59 21 , , , cord-023584-yaxawqhj 59 22 a a DT cord-023584-yaxawqhj 59 23 growing grow VBG cord-023584-yaxawqhj 59 24 catalog catalog NN cord-023584-yaxawqhj 59 25 of of IN cord-023584-yaxawqhj 59 26 coronaviruses coronaviruse NNS cord-023584-yaxawqhj 59 27 ( ( -LRB- cord-023584-yaxawqhj 59 28 Kapikian Kapikian NNP cord-023584-yaxawqhj 59 29 , , , cord-023584-yaxawqhj 59 30 1969 1969 CD cord-023584-yaxawqhj 59 31 ) ) -RRB- cord-023584-yaxawqhj 59 32 , , , cord-023584-yaxawqhj 59 33 and and CC cord-023584-yaxawqhj 59 34 a a DT cord-023584-yaxawqhj 59 35 selection selection NN cord-023584-yaxawqhj 59 36 of of IN cord-023584-yaxawqhj 59 37 other other JJ cord-023584-yaxawqhj 59 38 viruses virus NNS cord-023584-yaxawqhj 59 39 including include VBG cord-023584-yaxawqhj 59 40 myxoviruses myxovirus NNS cord-023584-yaxawqhj 59 41 , , , cord-023584-yaxawqhj 59 42 adenoviruses adenovirus NNS cord-023584-yaxawqhj 59 43 , , , cord-023584-yaxawqhj 59 44 and and CC cord-023584-yaxawqhj 59 45 herpcsviruses herpcsviruses NNP cord-023584-yaxawqhj 59 46 ( ( -LRB- cord-023584-yaxawqhj 59 47 Tyrrell Tyrrell NNP cord-023584-yaxawqhj 59 48 , , , cord-023584-yaxawqhj 59 49 1965 1965 CD cord-023584-yaxawqhj 59 50 ) ) -RRB- cord-023584-yaxawqhj 59 51 , , , cord-023584-yaxawqhj 59 52 all all DT cord-023584-yaxawqhj 59 53 of of IN cord-023584-yaxawqhj 59 54 which which WDT cord-023584-yaxawqhj 59 55 have have VBP cord-023584-yaxawqhj 59 56 been be VBN cord-023584-yaxawqhj 59 57 isolated isolate VBN cord-023584-yaxawqhj 59 58 from from IN cord-023584-yaxawqhj 59 59 clinical clinical JJ cord-023584-yaxawqhj 59 60 colds cold NNS cord-023584-yaxawqhj 59 61 . . . cord-023584-yaxawqhj 60 1 It -PRON- PRP cord-023584-yaxawqhj 60 2 is be VBZ cord-023584-yaxawqhj 60 3 the the DT cord-023584-yaxawqhj 60 4 serological serological JJ cord-023584-yaxawqhj 60 5 diversity diversity NN cord-023584-yaxawqhj 60 6 of of IN cord-023584-yaxawqhj 60 7 these these DT cord-023584-yaxawqhj 60 8 etiological etiological JJ cord-023584-yaxawqhj 60 9 agents agent NNS cord-023584-yaxawqhj 60 10 which which WDT cord-023584-yaxawqhj 60 11 makes make VBZ cord-023584-yaxawqhj 60 12 the the DT cord-023584-yaxawqhj 60 13 prospects prospect NNS cord-023584-yaxawqhj 60 14 for for IN cord-023584-yaxawqhj 60 15 a a DT cord-023584-yaxawqhj 60 16 vaccine vaccine NN cord-023584-yaxawqhj 60 17 so so RB cord-023584-yaxawqhj 60 18 poor poor JJ cord-023584-yaxawqhj 60 19 , , , cord-023584-yaxawqhj 60 20 and and CC cord-023584-yaxawqhj 60 21 the the DT cord-023584-yaxawqhj 60 22 common common JJ cord-023584-yaxawqhj 60 23 cold cold NN cord-023584-yaxawqhj 60 24 must must MD cord-023584-yaxawqhj 60 25 , , , cord-023584-yaxawqhj 60 26 therefore therefore RB cord-023584-yaxawqhj 60 27 , , , cord-023584-yaxawqhj 60 28 be be VB cord-023584-yaxawqhj 60 29 considered consider VBN cord-023584-yaxawqhj 60 30 as as IN cord-023584-yaxawqhj 60 31 a a DT cord-023584-yaxawqhj 60 32 target target NN cord-023584-yaxawqhj 60 33 , , , cord-023584-yaxawqhj 60 34 even even RB cord-023584-yaxawqhj 60 35 though though IN cord-023584-yaxawqhj 60 36 a a DT cord-023584-yaxawqhj 60 37 difficult difficult JJ cord-023584-yaxawqhj 60 38 target target NN cord-023584-yaxawqhj 60 39 , , , cord-023584-yaxawqhj 60 40 for for IN cord-023584-yaxawqhj 60 41 antiviral antiviral JJ cord-023584-yaxawqhj 60 42 drugs drug NNS cord-023584-yaxawqhj 60 43 . . . cord-023584-yaxawqhj 61 1 Besides besides IN cord-023584-yaxawqhj 61 2 the the DT cord-023584-yaxawqhj 61 3 problems problem NNS cord-023584-yaxawqhj 61 4 of of IN cord-023584-yaxawqhj 61 5 antigenic antigenic JJ cord-023584-yaxawqhj 61 6 variation variation NN cord-023584-yaxawqhj 61 7 , , , cord-023584-yaxawqhj 61 8 exemplified exemplify VBN cord-023584-yaxawqhj 61 9 by by IN cord-023584-yaxawqhj 61 10 influenza influenza NN cord-023584-yaxawqhj 61 11 , , , cord-023584-yaxawqhj 61 12 and and CC cord-023584-yaxawqhj 61 13 thc thc JJ cord-023584-yaxawqhj 61 14 multiplicity multiplicity NN cord-023584-yaxawqhj 61 15 of of IN cord-023584-yaxawqhj 61 16 serotypes serotype NNS cord-023584-yaxawqhj 61 17 , , , cord-023584-yaxawqhj 61 18 exemplified exemplify VBN cord-023584-yaxawqhj 61 19 by by IN cord-023584-yaxawqhj 61 20 the the DT cord-023584-yaxawqhj 61 21 common common JJ cord-023584-yaxawqhj 61 22 cold cold NN cord-023584-yaxawqhj 61 23 , , , cord-023584-yaxawqhj 61 24 there there EX cord-023584-yaxawqhj 61 25 are be VBP cord-023584-yaxawqhj 61 26 two two CD cord-023584-yaxawqhj 61 27 further further JJ cord-023584-yaxawqhj 61 28 problems problem NNS cord-023584-yaxawqhj 61 29 associated associate VBN cord-023584-yaxawqhj 61 30 with with IN cord-023584-yaxawqhj 61 31 the the DT cord-023584-yaxawqhj 61 32 control control NN cord-023584-yaxawqhj 61 33 of of IN cord-023584-yaxawqhj 61 34 respiratory respiratory JJ cord-023584-yaxawqhj 61 35 diseases disease NNS cord-023584-yaxawqhj 61 36 by by IN cord-023584-yaxawqhj 61 37 parmterally parmterally RB cord-023584-yaxawqhj 61 38 administered administer VBN cord-023584-yaxawqhj 61 39 vaccines vaccine NNS cord-023584-yaxawqhj 61 40 . . . cord-023584-yaxawqhj 62 1 The the DT cord-023584-yaxawqhj 62 2 first first JJ cord-023584-yaxawqhj 62 3 is be VBZ cord-023584-yaxawqhj 62 4 that that IN cord-023584-yaxawqhj 62 5 circulating circulate VBG cord-023584-yaxawqhj 62 6 antibodies antibody NNS cord-023584-yaxawqhj 62 7 appear appear VBP cord-023584-yaxawqhj 62 8 in in IN cord-023584-yaxawqhj 62 9 only only JJ cord-023584-yaxawqhj 62 10 small small JJ cord-023584-yaxawqhj 62 11 amounts amount NNS cord-023584-yaxawqhj 62 12 in in IN cord-023584-yaxawqhj 62 13 respiratory respiratory JJ cord-023584-yaxawqhj 62 14 mucus mucus NN cord-023584-yaxawqhj 62 15 , , , cord-023584-yaxawqhj 62 16 and and CC cord-023584-yaxawqhj 62 17 , , , cord-023584-yaxawqhj 62 18 consequently consequently RB cord-023584-yaxawqhj 62 19 , , , cord-023584-yaxawqhj 62 20 the the DT cord-023584-yaxawqhj 62 21 degree degree NN cord-023584-yaxawqhj 62 22 of of IN cord-023584-yaxawqhj 62 23 protection protection NN cord-023584-yaxawqhj 62 24 afforded afford VBN cord-023584-yaxawqhj 62 25 to to IN cord-023584-yaxawqhj 62 26 the the DT cord-023584-yaxawqhj 62 27 respiratory respiratory JJ cord-023584-yaxawqhj 62 28 tract tract NN cord-023584-yaxawqhj 62 29 is be VBZ cord-023584-yaxawqhj 62 30 less less JJR cord-023584-yaxawqhj 62 31 and and CC cord-023584-yaxawqhj 62 32 of of IN cord-023584-yaxawqhj 62 33 shorter short JJR cord-023584-yaxawqhj 62 34 duration duration NN cord-023584-yaxawqhj 62 35 than than IN cord-023584-yaxawqhj 62 36 might may MD cord-023584-yaxawqhj 62 37 be be VB cord-023584-yaxawqhj 62 38 expected expect VBN cord-023584-yaxawqhj 62 39 . . . cord-023584-yaxawqhj 63 1 The the DT cord-023584-yaxawqhj 63 2 second second JJ cord-023584-yaxawqhj 63 3 problem problem NN cord-023584-yaxawqhj 63 4 has have VBZ cord-023584-yaxawqhj 63 5 been be VBN cord-023584-yaxawqhj 63 6 brought bring VBN cord-023584-yaxawqhj 63 7 to to IN cord-023584-yaxawqhj 63 8 light light NN cord-023584-yaxawqhj 63 9 by by IN cord-023584-yaxawqhj 63 10 the the DT cord-023584-yaxawqhj 63 11 use use NN cord-023584-yaxawqhj 63 12 of of IN cord-023584-yaxawqhj 63 13 experimental experimental JJ cord-023584-yaxawqhj 63 14 vaccines vaccine NNS cord-023584-yaxawqhj 63 15 against against IN cord-023584-yaxawqhj 63 16 respiratory respiratory JJ cord-023584-yaxawqhj 63 17 syncytial syncytial JJ cord-023584-yaxawqhj 63 18 virus virus NN cord-023584-yaxawqhj 63 19 disease disease NN cord-023584-yaxawqhj 63 20 in in IN cord-023584-yaxawqhj 63 21 infants infant NNS cord-023584-yaxawqhj 63 22 . . . cord-023584-yaxawqhj 64 1 When when WRB cord-023584-yaxawqhj 64 2 infants infant NNS cord-023584-yaxawqhj 64 3 who who WP cord-023584-yaxawqhj 64 4 had have VBD cord-023584-yaxawqhj 64 5 been be VBN cord-023584-yaxawqhj 64 6 vaccinated vaccinate VBN cord-023584-yaxawqhj 64 7 parenterally parenterally NN cord-023584-yaxawqhj 64 8 against against IN cord-023584-yaxawqhj 64 9 this this DT cord-023584-yaxawqhj 64 10 disease disease NN cord-023584-yaxawqhj 64 11 contracted contract VBD cord-023584-yaxawqhj 64 12 the the DT cord-023584-yaxawqhj 64 13 natural natural JJ cord-023584-yaxawqhj 64 14 disease disease NN cord-023584-yaxawqhj 64 15 , , , cord-023584-yaxawqhj 64 16 they -PRON- PRP cord-023584-yaxawqhj 64 17 were be VBD cord-023584-yaxawqhj 64 18 more more RBR cord-023584-yaxawqhj 64 19 ill ill JJ cord-023584-yaxawqhj 64 20 than than IN cord-023584-yaxawqhj 64 21 infants infant NNS cord-023584-yaxawqhj 64 22 who who WP cord-023584-yaxawqhj 64 23 had have VBD cord-023584-yaxawqhj 64 24 not not RB cord-023584-yaxawqhj 64 25 received receive VBN cord-023584-yaxawqhj 64 26 the the DT cord-023584-yaxawqhj 64 27 vaccine vaccine NN cord-023584-yaxawqhj 64 28 . . . cord-023584-yaxawqhj 65 1 The the DT cord-023584-yaxawqhj 65 2 reason reason NN cord-023584-yaxawqhj 65 3 seems seem VBZ cord-023584-yaxawqhj 65 4 to to TO cord-023584-yaxawqhj 65 5 be be VB cord-023584-yaxawqhj 65 6 that that IN cord-023584-yaxawqhj 65 7 the the DT cord-023584-yaxawqhj 65 8 circulating circulate VBG cord-023584-yaxawqhj 65 9 antibodies antibody NNS cord-023584-yaxawqhj 65 10 resulting result VBG cord-023584-yaxawqhj 65 11 from from IN cord-023584-yaxawqhj 65 12 parenteral parenteral JJ cord-023584-yaxawqhj 65 13 vaccinations vaccination NNS cord-023584-yaxawqhj 65 14 not not RB cord-023584-yaxawqhj 65 15 only only RB cord-023584-yaxawqhj 65 16 offer offer VBP cord-023584-yaxawqhj 65 17 little little JJ cord-023584-yaxawqhj 65 18 protection protection NN cord-023584-yaxawqhj 65 19 to to IN cord-023584-yaxawqhj 65 20 the the DT cord-023584-yaxawqhj 65 21 respiratory respiratory JJ cord-023584-yaxawqhj 65 22 tract tract NN cord-023584-yaxawqhj 65 23 , , , cord-023584-yaxawqhj 65 24 but but CC cord-023584-yaxawqhj 65 25 when when WRB cord-023584-yaxawqhj 65 26 a a DT cord-023584-yaxawqhj 65 27 natural natural JJ cord-023584-yaxawqhj 65 28 infection infection NN cord-023584-yaxawqhj 65 29 occurs occur VBZ cord-023584-yaxawqhj 65 30 , , , cord-023584-yaxawqhj 65 31 these these DT cord-023584-yaxawqhj 65 32 antibodies antibody NNS cord-023584-yaxawqhj 65 33 combine combine VBP cord-023584-yaxawqhj 65 34 with with IN cord-023584-yaxawqhj 65 35 the the DT cord-023584-yaxawqhj 65 36 virus virus NN cord-023584-yaxawqhj 65 37 antigens antigen NNS cord-023584-yaxawqhj 65 38 at at IN cord-023584-yaxawqhj 65 39 the the DT cord-023584-yaxawqhj 65 40 surface surface NN cord-023584-yaxawqhj 65 41 of of IN cord-023584-yaxawqhj 65 42 the the DT cord-023584-yaxawqhj 65 43 respiratory respiratory JJ cord-023584-yaxawqhj 65 44 epithelial epithelial JJ cord-023584-yaxawqhj 65 45 cclls ccll NNS cord-023584-yaxawqhj 65 46 causing cause VBG cord-023584-yaxawqhj 65 47 an an DT cord-023584-yaxawqhj 65 48 inflammatory inflammatory JJ cord-023584-yaxawqhj 65 49 response response NN cord-023584-yaxawqhj 65 50 with with IN cord-023584-yaxawqhj 65 51 a a DT cord-023584-yaxawqhj 65 52 corresponding corresponding JJ cord-023584-yaxawqhj 65 53 increase increase NN cord-023584-yaxawqhj 65 54 in in IN cord-023584-yaxawqhj 65 55 the the DT cord-023584-yaxawqhj 65 56 severity severity NN cord-023584-yaxawqhj 65 57 of of IN cord-023584-yaxawqhj 65 58 clinical clinical JJ cord-023584-yaxawqhj 65 59 symptoms symptom NNS cord-023584-yaxawqhj 65 60 Kim Kim NNP cord-023584-yaxawqhj 65 61 et et NNP cord-023584-yaxawqhj 65 62 al al NNP cord-023584-yaxawqhj 65 63 . . NNP cord-023584-yaxawqhj 65 64 , , , cord-023584-yaxawqhj 65 65 1969 1969 CD cord-023584-yaxawqhj 65 66 ; ; : cord-023584-yaxawqhj 65 67 Kapikian Kapikian NNP cord-023584-yaxawqhj 65 68 et et NNP cord-023584-yaxawqhj 65 69 al al NNP cord-023584-yaxawqhj 65 70 . . NNP cord-023584-yaxawqhj 65 71 , , , cord-023584-yaxawqhj 65 72 1969 1969 CD cord-023584-yaxawqhj 65 73 ) ) -RRB- cord-023584-yaxawqhj 65 74 . . . cord-023584-yaxawqhj 66 1 Chanock Chanock NNP cord-023584-yaxawqhj 66 2 et et NN cord-023584-yaxawqhj 66 3 a2 a2 NN cord-023584-yaxawqhj 66 4 . . . cord-023584-yaxawqhj 67 1 ( ( -LRB- cord-023584-yaxawqhj 67 2 1970 1970 CD cord-023584-yaxawqhj 67 3 ) ) -RRB- cord-023584-yaxawqhj 67 4 have have VBP cord-023584-yaxawqhj 67 5 pointed point VBN cord-023584-yaxawqhj 67 6 out out RP cord-023584-yaxawqhj 67 7 that that IN cord-023584-yaxawqhj 67 8 if if IN cord-023584-yaxawqhj 67 9 an an DT cord-023584-yaxawqhj 67 10 immunopathological immunopathological JJ cord-023584-yaxawqhj 67 11 process process NN cord-023584-yaxawqhj 67 12 involving involve VBG cord-023584-yaxawqhj 67 13 serum serum NN cord-023584-yaxawqhj 67 14 antibodies antibody NNS cord-023584-yaxawqhj 67 15 occurs occur VBZ cord-023584-yaxawqhj 67 16 during during IN cord-023584-yaxawqhj 67 17 respiratory respiratory JJ cord-023584-yaxawqhj 67 18 syncytial syncytial JJ cord-023584-yaxawqhj 67 19 virus virus NN cord-023584-yaxawqhj 67 20 infection infection NN cord-023584-yaxawqhj 67 21 , , , cord-023584-yaxawqhj 67 22 then then RB cord-023584-yaxawqhj 67 23 stimulation stimulation NN cord-023584-yaxawqhj 67 24 of of IN cord-023584-yaxawqhj 67 25 local local JJ cord-023584-yaxawqhj 67 26 , , , cord-023584-yaxawqhj 67 27 respiratory respiratory JJ cord-023584-yaxawqhj 67 28 tract tract NN cord-023584-yaxawqhj 67 29 , , , cord-023584-yaxawqhj 67 30 secretory secretory JJ cord-023584-yaxawqhj 67 31 antibody antibody NN cord-023584-yaxawqhj 67 32 by by IN cord-023584-yaxawqhj 67 33 intranasal intranasal NN cord-023584-yaxawqhj 67 34 instillation instillation NN cord-023584-yaxawqhj 67 35 of of IN cord-023584-yaxawqhj 67 36 live live JJ cord-023584-yaxawqhj 67 37 or or CC cord-023584-yaxawqhj 67 38 inactivated inactivate VBN cord-023584-yaxawqhj 67 39 virus virus NN cord-023584-yaxawqhj 67 40 may may MD cord-023584-yaxawqhj 67 41 give give VB cord-023584-yaxawqhj 67 42 adequate adequate JJ cord-023584-yaxawqhj 67 43 protection protection NN cord-023584-yaxawqhj 67 44 without without IN cord-023584-yaxawqhj 67 45 unwanted unwanted JJ cord-023584-yaxawqhj 67 46 hyperreactivity hyperreactivity NN cord-023584-yaxawqhj 67 47 . . . cord-023584-yaxawqhj 68 1 A a DT cord-023584-yaxawqhj 68 2 similar similar JJ cord-023584-yaxawqhj 68 3 allergic allergic JJ cord-023584-yaxawqhj 68 4 reaction reaction NN cord-023584-yaxawqhj 68 5 between between IN cord-023584-yaxawqhj 68 6 virus virus NN cord-023584-yaxawqhj 68 7 antigen antigen NN cord-023584-yaxawqhj 68 8 and and CC cord-023584-yaxawqhj 68 9 preexisting preexisting JJ cord-023584-yaxawqhj 68 10 antibody antibody NN cord-023584-yaxawqhj 68 11 is be VBZ cord-023584-yaxawqhj 68 12 a a DT cord-023584-yaxawqhj 68 13 factor factor NN cord-023584-yaxawqhj 68 14 , , , cord-023584-yaxawqhj 68 15 possibly possibly RB cord-023584-yaxawqhj 68 16 a a DT cord-023584-yaxawqhj 68 17 major major JJ cord-023584-yaxawqhj 68 18 factor factor NN cord-023584-yaxawqhj 68 19 , , , cord-023584-yaxawqhj 68 20 in in IN cord-023584-yaxawqhj 68 21 the the DT cord-023584-yaxawqhj 68 22 pathological pathological JJ cord-023584-yaxawqhj 68 23 processes process NNS cord-023584-yaxawqhj 68 24 initiated initiate VBN cord-023584-yaxawqhj 68 25 by by IN cord-023584-yaxawqhj 68 26 herpesviruses herpesviruses NNP cord-023584-yaxawqhj 68 27 ( ( -LRB- cord-023584-yaxawqhj 68 28 Jones Jones NNP cord-023584-yaxawqhj 68 29 and and CC cord-023584-yaxawqhj 68 30 Patterson Patterson NNP cord-023584-yaxawqhj 68 31 , , , cord-023584-yaxawqhj 68 32 1967 1967 CD cord-023584-yaxawqhj 68 33 ) ) -RRB- cord-023584-yaxawqhj 68 34 and and CC cord-023584-yaxawqhj 68 35 marks mark VBZ cord-023584-yaxawqhj 68 36 the the DT cord-023584-yaxawqhj 68 37 herpes herpes NN cord-023584-yaxawqhj 68 38 diseases disease NNS cord-023584-yaxawqhj 68 39 as as IN cord-023584-yaxawqhj 68 40 possible possible JJ cord-023584-yaxawqhj 68 41 candidates candidate NNS cord-023584-yaxawqhj 68 42 for for IN cord-023584-yaxawqhj 68 43 antiviral antiviral JJ cord-023584-yaxawqhj 68 44 drug drug NN cord-023584-yaxawqhj 68 45 development development NN cord-023584-yaxawqhj 68 46 . . . cord-023584-yaxawqhj 69 1 One one CD cord-023584-yaxawqhj 69 2 factor factor NN cord-023584-yaxawqhj 69 3 that that WDT cord-023584-yaxawqhj 69 4 deserves deserve VBZ cord-023584-yaxawqhj 69 5 more more RBR cord-023584-yaxawqhj 69 6 careful careful JJ cord-023584-yaxawqhj 69 7 consideration consideration NN cord-023584-yaxawqhj 69 8 than than IN cord-023584-yaxawqhj 69 9 it -PRON- PRP cord-023584-yaxawqhj 69 10 usually usually RB cord-023584-yaxawqhj 69 11 receives receive VBZ cord-023584-yaxawqhj 69 12 is be VBZ cord-023584-yaxawqhj 69 13 the the DT cord-023584-yaxawqhj 69 14 way way NN cord-023584-yaxawqhj 69 15 in in IN cord-023584-yaxawqhj 69 16 which which WDT cord-023584-yaxawqhj 69 17 a a DT cord-023584-yaxawqhj 69 18 potential potential JJ cord-023584-yaxawqhj 69 19 antiviral antiviral JJ cord-023584-yaxawqhj 69 20 drug drug NN cord-023584-yaxawqhj 69 21 would would MD cord-023584-yaxawqhj 69 22 be be VB cord-023584-yaxawqhj 69 23 administered administer VBN cord-023584-yaxawqhj 69 24 to to IN cord-023584-yaxawqhj 69 25 the the DT cord-023584-yaxawqhj 69 26 animal animal NN cord-023584-yaxawqhj 69 27 or or CC cord-023584-yaxawqhj 69 28 patient patient JJ cord-023584-yaxawqhj 69 29 requiring require VBG cord-023584-yaxawqhj 69 30 protection protection NN cord-023584-yaxawqhj 69 31 . . . cord-023584-yaxawqhj 70 1 Clearly clearly RB cord-023584-yaxawqhj 70 2 a a DT cord-023584-yaxawqhj 70 3 common common JJ cord-023584-yaxawqhj 70 4 cold cold JJ cord-023584-yaxawqhj 70 5 treatment treatment NN cord-023584-yaxawqhj 70 6 would would MD cord-023584-yaxawqhj 70 7 be be VB cord-023584-yaxawqhj 70 8 unacceptable unacceptable JJ cord-023584-yaxawqhj 70 9 if if IN cord-023584-yaxawqhj 70 10 it -PRON- PRP cord-023584-yaxawqhj 70 11 had have VBD cord-023584-yaxawqhj 70 12 to to TO cord-023584-yaxawqhj 70 13 be be VB cord-023584-yaxawqhj 70 14 given give VBN cord-023584-yaxawqhj 70 15 intravenously intravenously RB cord-023584-yaxawqhj 70 16 3 3 CD cord-023584-yaxawqhj 70 17 times time NNS cord-023584-yaxawqhj 70 18 a a DT cord-023584-yaxawqhj 70 19 day day NN cord-023584-yaxawqhj 70 20 . . . cord-023584-yaxawqhj 71 1 But but CC cord-023584-yaxawqhj 71 2 there there EX cord-023584-yaxawqhj 71 3 are be VBP cord-023584-yaxawqhj 71 4 less less RBR cord-023584-yaxawqhj 71 5 obvious obvious JJ cord-023584-yaxawqhj 71 6 , , , cord-023584-yaxawqhj 71 7 but but CC cord-023584-yaxawqhj 71 8 no no DT cord-023584-yaxawqhj 71 9 less less RBR cord-023584-yaxawqhj 71 10 real real JJ cord-023584-yaxawqhj 71 11 , , , cord-023584-yaxawqhj 71 12 difficulties difficulty NNS cord-023584-yaxawqhj 71 13 in in IN cord-023584-yaxawqhj 71 14 dosing dose VBG cord-023584-yaxawqhj 71 15 large large JJ cord-023584-yaxawqhj 71 16 herds herd NNS cord-023584-yaxawqhj 71 17 of of IN cord-023584-yaxawqhj 71 18 cattle cattle NNS cord-023584-yaxawqhj 71 19 or or CC cord-023584-yaxawqhj 71 20 sheep sheep NN cord-023584-yaxawqhj 71 21 so so IN cord-023584-yaxawqhj 71 22 that that IN cord-023584-yaxawqhj 71 23 effective effective JJ cord-023584-yaxawqhj 71 24 protection protection NN cord-023584-yaxawqhj 71 25 is be VBZ cord-023584-yaxawqhj 71 26 maintained maintain VBN cord-023584-yaxawqhj 71 27 . . . cord-023584-yaxawqhj 72 1 With with IN cord-023584-yaxawqhj 72 2 freeranging freerange VBG cord-023584-yaxawqhj 72 3 animals animal NNS cord-023584-yaxawqhj 72 4 the the DT cord-023584-yaxawqhj 72 5 duration duration NN cord-023584-yaxawqhj 72 6 of of IN cord-023584-yaxawqhj 72 7 protection protection NN cord-023584-yaxawqhj 72 8 from from IN cord-023584-yaxawqhj 72 9 a a DT cord-023584-yaxawqhj 72 10 single single JJ cord-023584-yaxawqhj 72 11 dose dose NN cord-023584-yaxawqhj 72 12 would would MD cord-023584-yaxawqhj 72 13 need need VB cord-023584-yaxawqhj 72 14 to to TO cord-023584-yaxawqhj 72 15 be be VB cord-023584-yaxawqhj 72 16 prolonged prolong VBN cord-023584-yaxawqhj 72 17 to to TO cord-023584-yaxawqhj 72 18 offset offset VB cord-023584-yaxawqhj 72 19 the the DT cord-023584-yaxawqhj 72 20 labor labor NN cord-023584-yaxawqhj 72 21 of of IN cord-023584-yaxawqhj 72 22 administering administer VBG cord-023584-yaxawqhj 72 23 the the DT cord-023584-yaxawqhj 72 24 dose dose NN cord-023584-yaxawqhj 72 25 . . . cord-023584-yaxawqhj 73 1 Also also RB cord-023584-yaxawqhj 73 2 , , , cord-023584-yaxawqhj 73 3 it -PRON- PRP cord-023584-yaxawqhj 73 4 is be VBZ cord-023584-yaxawqhj 73 5 easier easy JJR cord-023584-yaxawqhj 73 6 to to TO cord-023584-yaxawqhj 73 7 dose dose VB cord-023584-yaxawqhj 73 8 herds herd NNS cord-023584-yaxawqhj 73 9 by by IN cord-023584-yaxawqhj 73 10 injection injection NN cord-023584-yaxawqhj 73 11 than than IN cord-023584-yaxawqhj 73 12 by by IN cord-023584-yaxawqhj 73 13 mouth mouth NN cord-023584-yaxawqhj 73 14 , , , cord-023584-yaxawqhj 73 15 so so IN cord-023584-yaxawqhj 73 16 that that IN cord-023584-yaxawqhj 73 17 certain certain JJ cord-023584-yaxawqhj 73 18 veterinary veterinary JJ cord-023584-yaxawqhj 73 19 antiviral antiviral JJ cord-023584-yaxawqhj 73 20 drugs drug NNS cord-023584-yaxawqhj 73 21 may may MD cord-023584-yaxawqhj 73 22 not not RB cord-023584-yaxawqhj 73 23 be be VB cord-023584-yaxawqhj 73 24 required require VBN cord-023584-yaxawqhj 73 25 in in IN cord-023584-yaxawqhj 73 26 an an DT cord-023584-yaxawqhj 73 27 orally orally RB cord-023584-yaxawqhj 73 28 active active JJ cord-023584-yaxawqhj 73 29 formulation formulation NN cord-023584-yaxawqhj 73 30 . . . cord-023584-yaxawqhj 74 1 Conversely conversely RB cord-023584-yaxawqhj 74 2 , , , cord-023584-yaxawqhj 74 3 oral oral JJ cord-023584-yaxawqhj 74 4 dosing dosing NN cord-023584-yaxawqhj 74 5 , , , cord-023584-yaxawqhj 74 6 preferably preferably RB cord-023584-yaxawqhj 74 7 by by IN cord-023584-yaxawqhj 74 8 an an DT cord-023584-yaxawqhj 74 9 addition addition NN cord-023584-yaxawqhj 74 10 to to IN cord-023584-yaxawqhj 74 11 food food NN cord-023584-yaxawqhj 74 12 or or CC cord-023584-yaxawqhj 74 13 drinking drinking NN cord-023584-yaxawqhj 74 14 water water NN cord-023584-yaxawqhj 74 15 , , , cord-023584-yaxawqhj 74 16 is be VBZ cord-023584-yaxawqhj 74 17 the the DT cord-023584-yaxawqhj 74 18 most most RBS cord-023584-yaxawqhj 74 19 convenient convenient JJ cord-023584-yaxawqhj 74 20 way way NN cord-023584-yaxawqhj 74 21 of of IN cord-023584-yaxawqhj 74 22 dosing dose VBG cord-023584-yaxawqhj 74 23 poultry poultry NN cord-023584-yaxawqhj 74 24 . . . cord-023584-yaxawqhj 75 1 The the DT cord-023584-yaxawqhj 75 2 onset onset NN cord-023584-yaxawqhj 75 3 of of IN cord-023584-yaxawqhj 75 4 symptoms symptom NNS cord-023584-yaxawqhj 75 5 in in IN cord-023584-yaxawqhj 75 6 most most JJS cord-023584-yaxawqhj 75 7 virus virus NN cord-023584-yaxawqhj 75 8 diseases disease NNS cord-023584-yaxawqhj 75 9 is be VBZ cord-023584-yaxawqhj 75 10 acute acute JJ cord-023584-yaxawqhj 75 11 and and CC cord-023584-yaxawqhj 75 12 may may MD cord-023584-yaxawqhj 75 13 be be VB cord-023584-yaxawqhj 75 14 the the DT cord-023584-yaxawqhj 75 15 first first JJ cord-023584-yaxawqhj 75 16 indication indication NN cord-023584-yaxawqhj 75 17 that that IN cord-023584-yaxawqhj 75 18 the the DT cord-023584-yaxawqhj 75 19 host host NN cord-023584-yaxawqhj 75 20 has have VBZ cord-023584-yaxawqhj 75 21 contracted contract VBN cord-023584-yaxawqhj 75 22 an an DT cord-023584-yaxawqhj 75 23 infection infection NN cord-023584-yaxawqhj 75 24 . . . cord-023584-yaxawqhj 76 1 Because because IN cord-023584-yaxawqhj 76 2 of of IN cord-023584-yaxawqhj 76 3 this this DT cord-023584-yaxawqhj 76 4 , , , cord-023584-yaxawqhj 76 5 it -PRON- PRP cord-023584-yaxawqhj 76 6 is be VBZ cord-023584-yaxawqhj 76 7 usually usually RB cord-023584-yaxawqhj 76 8 assumed assume VBN cord-023584-yaxawqhj 76 9 that that IN cord-023584-yaxawqhj 76 10 antiviral antiviral JJ cord-023584-yaxawqhj 76 11 drugs drug NNS cord-023584-yaxawqhj 76 12 will will MD cord-023584-yaxawqhj 76 13 only only RB cord-023584-yaxawqhj 76 14 be be VB cord-023584-yaxawqhj 76 15 of of IN cord-023584-yaxawqhj 76 16 value value NN cord-023584-yaxawqhj 76 17 in in IN cord-023584-yaxawqhj 76 18 preventing prevent VBG cord-023584-yaxawqhj 76 19 and and CC cord-023584-yaxawqhj 76 20 not not RB cord-023584-yaxawqhj 76 21 in in IN cord-023584-yaxawqhj 76 22 curing cure VBG cord-023584-yaxawqhj 76 23 virus virus NN cord-023584-yaxawqhj 76 24 diseases disease NNS cord-023584-yaxawqhj 76 25 . . . cord-023584-yaxawqhj 77 1 Nevertheless nevertheless RB cord-023584-yaxawqhj 77 2 , , , cord-023584-yaxawqhj 77 3 although although IN cord-023584-yaxawqhj 77 4 the the DT cord-023584-yaxawqhj 77 5 periods period NNS cord-023584-yaxawqhj 77 6 of of IN cord-023584-yaxawqhj 77 7 virus virus NN cord-023584-yaxawqhj 77 8 growth growth NN cord-023584-yaxawqhj 77 9 in in IN cord-023584-yaxawqhj 77 10 infected infected JJ cord-023584-yaxawqhj 77 11 individuals individual NNS cord-023584-yaxawqhj 77 12 may may MD cord-023584-yaxawqhj 77 13 be be VB cord-023584-yaxawqhj 77 14 short short JJ cord-023584-yaxawqhj 77 15 , , , cord-023584-yaxawqhj 77 16 they -PRON- PRP cord-023584-yaxawqhj 77 17 may may MD cord-023584-yaxawqhj 77 18 well well RB cord-023584-yaxawqhj 77 19 be be VB cord-023584-yaxawqhj 77 20 long long RB cord-023584-yaxawqhj 77 21 enough enough RB cord-023584-yaxawqhj 77 22 to to TO cord-023584-yaxawqhj 77 23 allow allow VB cord-023584-yaxawqhj 77 24 useful useful JJ cord-023584-yaxawqhj 77 25 therapy therapy NN cord-023584-yaxawqhj 77 26 . . . cord-023584-yaxawqhj 78 1 For for IN cord-023584-yaxawqhj 78 2 example example NN cord-023584-yaxawqhj 78 3 , , , cord-023584-yaxawqhj 78 4 Pate1 Pate1 NNP cord-023584-yaxawqhj 78 5 et et NNP cord-023584-yaxawqhj 78 6 al al NNP cord-023584-yaxawqhj 78 7 . . . cord-023584-yaxawqhj 79 1 ( ( -LRB- cord-023584-yaxawqhj 79 2 1964 1964 CD cord-023584-yaxawqhj 79 3 ) ) -RRB- cord-023584-yaxawqhj 79 4 have have VBP cord-023584-yaxawqhj 79 5 shown show VBN cord-023584-yaxawqhj 79 6 in in IN cord-023584-yaxawqhj 79 7 volunteers volunteer NNS cord-023584-yaxawqhj 79 8 infected infect VBN cord-023584-yaxawqhj 79 9 intranasally intranasally RB cord-023584-yaxawqhj 79 10 with with IN cord-023584-yaxawqhj 79 11 Coxsackie Coxsackie NNP cord-023584-yaxawqhj 79 12 A21 A21 NNP cord-023584-yaxawqhj 79 13 virus virus NN cord-023584-yaxawqhj 79 14 that that WDT cord-023584-yaxawqhj 79 15 maximum maximum JJ cord-023584-yaxawqhj 79 16 virus virus NN cord-023584-yaxawqhj 79 17 growth growth NN cord-023584-yaxawqhj 79 18 precedes precede VBZ cord-023584-yaxawqhj 79 19 the the DT cord-023584-yaxawqhj 79 20 onset onset NN cord-023584-yaxawqhj 79 21 of of IN cord-023584-yaxawqhj 79 22 symptoms symptom NNS cord-023584-yaxawqhj 79 23 by by IN cord-023584-yaxawqhj 79 24 24 24 CD cord-023584-yaxawqhj 79 25 hours hour NNS cord-023584-yaxawqhj 79 26 . . . cord-023584-yaxawqhj 80 1 But but CC cord-023584-yaxawqhj 80 2 from from IN cord-023584-yaxawqhj 80 3 their -PRON- PRP$ cord-023584-yaxawqhj 80 4 work work NN cord-023584-yaxawqhj 80 5 it -PRON- PRP cord-023584-yaxawqhj 80 6 may may MD cord-023584-yaxawqhj 80 7 be be VB cord-023584-yaxawqhj 80 8 seen see VBN cord-023584-yaxawqhj 80 9 that that IN cord-023584-yaxawqhj 80 10 a a DT cord-023584-yaxawqhj 80 11 considerable considerable JJ cord-023584-yaxawqhj 80 12 amount amount NN cord-023584-yaxawqhj 80 13 of of IN cord-023584-yaxawqhj 80 14 virus virus NN cord-023584-yaxawqhj 80 15 growth growth NN cord-023584-yaxawqhj 80 16 is be VBZ cord-023584-yaxawqhj 80 17 concurrent concurrent JJ cord-023584-yaxawqhj 80 18 with with IN cord-023584-yaxawqhj 80 19 the the DT cord-023584-yaxawqhj 80 20 period period NN cord-023584-yaxawqhj 80 21 of of IN cord-023584-yaxawqhj 80 22 overt overt JJ cord-023584-yaxawqhj 80 23 symptoms symptom NNS cord-023584-yaxawqhj 80 24 , , , cord-023584-yaxawqhj 80 25 and and CC cord-023584-yaxawqhj 80 26 application application NN cord-023584-yaxawqhj 80 27 of of IN cord-023584-yaxawqhj 80 28 antiviral antiviral JJ cord-023584-yaxawqhj 80 29 drugs drug NNS cord-023584-yaxawqhj 80 30 during during IN cord-023584-yaxawqhj 80 31 this this DT cord-023584-yaxawqhj 80 32 period period NN cord-023584-yaxawqhj 80 33 of of IN cord-023584-yaxawqhj 80 34 2 2 CD cord-023584-yaxawqhj 80 35 - - SYM cord-023584-yaxawqhj 80 36 3 3 CD cord-023584-yaxawqhj 80 37 days day NNS cord-023584-yaxawqhj 80 38 might may MD cord-023584-yaxawqhj 80 39 well well RB cord-023584-yaxawqhj 80 40 prevent prevent VB cord-023584-yaxawqhj 80 41 the the DT cord-023584-yaxawqhj 80 42 full full JJ cord-023584-yaxawqhj 80 43 development development NN cord-023584-yaxawqhj 80 44 of of IN cord-023584-yaxawqhj 80 45 the the DT cord-023584-yaxawqhj 80 46 disease disease NN cord-023584-yaxawqhj 80 47 . . . cord-023584-yaxawqhj 81 1 The the DT cord-023584-yaxawqhj 81 2 work work NN cord-023584-yaxawqhj 81 3 of of IN cord-023584-yaxawqhj 81 4 Douglas Douglas NNP cord-023584-yaxawqhj 81 5 et et NNP cord-023584-yaxawqhj 81 6 al al NNP cord-023584-yaxawqhj 81 7 . . . cord-023584-yaxawqhj 82 1 ( ( -LRB- cord-023584-yaxawqhj 82 2 1966 1966 CD cord-023584-yaxawqhj 82 3 ) ) -RRB- cord-023584-yaxawqhj 82 4 with with IN cord-023584-yaxawqhj 82 5 volunteers volunteer NNS cord-023584-yaxawqhj 82 6 shows show VBZ cord-023584-yaxawqhj 82 7 that that IN cord-023584-yaxawqhj 82 8 a a DT cord-023584-yaxawqhj 82 9 similar similar JJ cord-023584-yaxawqhj 82 10 period period NN cord-023584-yaxawqhj 82 11 exists exist VBZ cord-023584-yaxawqhj 82 12 in in IN cord-023584-yaxawqhj 82 13 acute acute JJ cord-023584-yaxawqhj 82 14 rhinovirus rhinovirus NN cord-023584-yaxawqhj 82 15 infections infection NNS cord-023584-yaxawqhj 82 16 , , , cord-023584-yaxawqhj 82 17 and and CC cord-023584-yaxawqhj 82 18 Dawkins Dawkins NNP cord-023584-yaxawqhj 82 19 et et NNP cord-023584-yaxawqhj 82 20 al al NNP cord-023584-yaxawqhj 82 21 . . . cord-023584-yaxawqhj 83 1 ( ( -LRB- cord-023584-yaxawqhj 83 2 1968 1968 CD cord-023584-yaxawqhj 83 3 ) ) -RRB- cord-023584-yaxawqhj 83 4 and and CC cord-023584-yaxawqhj 83 5 Wingfield Wingfield NNP cord-023584-yaxawqhj 83 6 et et NNP cord-023584-yaxawqhj 83 7 al al NNP cord-023584-yaxawqhj 83 8 . . . cord-023584-yaxawqhj 84 1 ( ( -LRB- cord-023584-yaxawqhj 84 2 1969 1969 CD cord-023584-yaxawqhj 84 3 ) ) -RRB- cord-023584-yaxawqhj 84 4 have have VBP cord-023584-yaxawqhj 84 5 shown show VBN cord-023584-yaxawqhj 84 6 that that IN cord-023584-yaxawqhj 84 7 the the DT cord-023584-yaxawqhj 84 8 course course NN cord-023584-yaxawqhj 84 9 of of IN cord-023584-yaxawqhj 84 10 influenza influenza NN cord-023584-yaxawqhj 84 11 in in IN cord-023584-yaxawqhj 84 12 humans human NNS cord-023584-yaxawqhj 84 13 can can MD cord-023584-yaxawqhj 84 14 be be VB cord-023584-yaxawqhj 84 15 modified modify VBN cord-023584-yaxawqhj 84 16 , , , cord-023584-yaxawqhj 84 17 even even RB cord-023584-yaxawqhj 84 18 after after IN cord-023584-yaxawqhj 84 19 the the DT cord-023584-yaxawqhj 84 20 onset onset NN cord-023584-yaxawqhj 84 21 of of IN cord-023584-yaxawqhj 84 22 symptoms symptom NNS cord-023584-yaxawqhj 84 23 , , , cord-023584-yaxawqhj 84 24 by by IN cord-023584-yaxawqhj 84 25 treatment treatment NN cord-023584-yaxawqhj 84 26 with with IN cord-023584-yaxawqhj 84 27 1-aminoadamantane 1-aminoadamantane CD cord-023584-yaxawqhj 84 28 . . . cord-023584-yaxawqhj 85 1 It -PRON- PRP cord-023584-yaxawqhj 85 2 hardly hardly RB cord-023584-yaxawqhj 85 3 seems seem VBZ cord-023584-yaxawqhj 85 4 necessary necessary JJ cord-023584-yaxawqhj 85 5 to to TO cord-023584-yaxawqhj 85 6 point point VB cord-023584-yaxawqhj 85 7 out out RP cord-023584-yaxawqhj 85 8 that that IN cord-023584-yaxawqhj 85 9 before before IN cord-023584-yaxawqhj 85 10 undertaking undertake VBG cord-023584-yaxawqhj 85 11 a a DT cord-023584-yaxawqhj 85 12 search search NN cord-023584-yaxawqhj 85 13 for for IN cord-023584-yaxawqhj 85 14 a a DT cord-023584-yaxawqhj 85 15 drug drug NN cord-023584-yaxawqhj 85 16 against against IN cord-023584-yaxawqhj 85 17 a a DT cord-023584-yaxawqhj 85 18 particular particular JJ cord-023584-yaxawqhj 85 19 disease disease NN cord-023584-yaxawqhj 85 20 , , , cord-023584-yaxawqhj 85 21 the the DT cord-023584-yaxawqhj 85 22 etiological etiological JJ cord-023584-yaxawqhj 85 23 agent agent NN cord-023584-yaxawqhj 85 24 of of IN cord-023584-yaxawqhj 85 25 the the DT cord-023584-yaxawqhj 85 26 disease disease NN cord-023584-yaxawqhj 85 27 should should MD cord-023584-yaxawqhj 85 28 be be VB cord-023584-yaxawqhj 85 29 unequivocally unequivocally RB cord-023584-yaxawqhj 85 30 identified identify VBN cord-023584-yaxawqhj 85 31 . . . cord-023584-yaxawqhj 86 1 There there EX cord-023584-yaxawqhj 86 2 are be VBP cord-023584-yaxawqhj 86 3 a a DT cord-023584-yaxawqhj 86 4 number number NN cord-023584-yaxawqhj 86 5 of of IN cord-023584-yaxawqhj 86 6 important important JJ cord-023584-yaxawqhj 86 7 virus virus NN cord-023584-yaxawqhj 86 8 diseases disease NNS cord-023584-yaxawqhj 86 9 for for IN cord-023584-yaxawqhj 86 10 which which WDT cord-023584-yaxawqhj 86 11 the the DT cord-023584-yaxawqhj 86 12 causative causative JJ cord-023584-yaxawqhj 86 13 agent agent NN cord-023584-yaxawqhj 86 14 is be VBZ cord-023584-yaxawqhj 86 15 either either CC cord-023584-yaxawqhj 86 16 unknown unknown JJ cord-023584-yaxawqhj 86 17 or or CC cord-023584-yaxawqhj 86 18 is be VBZ cord-023584-yaxawqhj 86 19 in in IN cord-023584-yaxawqhj 86 20 doubt doubt NN cord-023584-yaxawqhj 86 21 , , , cord-023584-yaxawqhj 86 22 for for IN cord-023584-yaxawqhj 86 23 example example NN cord-023584-yaxawqhj 86 24 , , , cord-023584-yaxawqhj 86 25 bovine bovine JJ cord-023584-yaxawqhj 86 26 pneumonia pneumonia NN cord-023584-yaxawqhj 86 27 and and CC cord-023584-yaxawqhj 86 28 human human JJ cord-023584-yaxawqhj 86 29 epidemic epidemic NN cord-023584-yaxawqhj 86 30 viral viral JJ cord-023584-yaxawqhj 86 31 gasteroenteritis gasteroenteritis NN cord-023584-yaxawqhj 86 32 . . . cord-023584-yaxawqhj 87 1 It -PRON- PRP cord-023584-yaxawqhj 87 2 would would MD cord-023584-yaxawqhj 87 3 be be VB cord-023584-yaxawqhj 87 4 a a DT cord-023584-yaxawqhj 87 5 mistake mistake NN cord-023584-yaxawqhj 87 6 to to TO cord-023584-yaxawqhj 87 7 set set VB cord-023584-yaxawqhj 87 8 up up RP cord-023584-yaxawqhj 87 9 screens screen NNS cord-023584-yaxawqhj 87 10 against against IN cord-023584-yaxawqhj 87 11 agents agent NNS cord-023584-yaxawqhj 87 12 that that WDT cord-023584-yaxawqhj 87 13 were be VBD cord-023584-yaxawqhj 87 14 only only RB cord-023584-yaxawqhj 87 15 suspected suspect VBN cord-023584-yaxawqhj 87 16 of of IN cord-023584-yaxawqhj 87 17 being be VBG cord-023584-yaxawqhj 87 18 implicated implicate VBN cord-023584-yaxawqhj 87 19 in in IN cord-023584-yaxawqhj 87 20 these these DT cord-023584-yaxawqhj 87 21 diseases disease NNS cord-023584-yaxawqhj 87 22 in in IN cord-023584-yaxawqhj 87 23 case case NN cord-023584-yaxawqhj 87 24 subsequent subsequent JJ cord-023584-yaxawqhj 87 25 work work NN cord-023584-yaxawqhj 87 26 should should MD cord-023584-yaxawqhj 87 27 demonstrate demonstrate VB cord-023584-yaxawqhj 87 28 that that IN cord-023584-yaxawqhj 87 29 these these DT cord-023584-yaxawqhj 87 30 were be VBD cord-023584-yaxawqhj 87 31 not not RB cord-023584-yaxawqhj 87 32 in in IN cord-023584-yaxawqhj 87 33 fact fact NN cord-023584-yaxawqhj 87 34 the the DT cord-023584-yaxawqhj 87 35 causative causative JJ cord-023584-yaxawqhj 87 36 agents agent NNS cord-023584-yaxawqhj 87 37 . . . cord-023584-yaxawqhj 88 1 Although although IN cord-023584-yaxawqhj 88 2 it -PRON- PRP cord-023584-yaxawqhj 88 3 is be VBZ cord-023584-yaxawqhj 88 4 difficult difficult JJ cord-023584-yaxawqhj 88 5 to to TO cord-023584-yaxawqhj 88 6 predict predict VB cord-023584-yaxawqhj 88 7 changes change NNS cord-023584-yaxawqhj 88 8 in in IN cord-023584-yaxawqhj 88 9 governmental governmental JJ cord-023584-yaxawqhj 88 10 legislation legislation NN cord-023584-yaxawqhj 88 11 toward toward IN cord-023584-yaxawqhj 88 12 public public JJ cord-023584-yaxawqhj 88 13 or or CC cord-023584-yaxawqhj 88 14 animal animal NN cord-023584-yaxawqhj 88 15 health health NN cord-023584-yaxawqhj 88 16 , , , cord-023584-yaxawqhj 88 17 nevertheless nevertheless RB cord-023584-yaxawqhj 88 18 , , , cord-023584-yaxawqhj 88 19 the the DT cord-023584-yaxawqhj 88 20 existing exist VBG cord-023584-yaxawqhj 88 21 and and CC cord-023584-yaxawqhj 88 22 prospective prospective JJ cord-023584-yaxawqhj 88 23 legal legal JJ cord-023584-yaxawqhj 88 24 position position NN cord-023584-yaxawqhj 88 25 in in IN cord-023584-yaxawqhj 88 26 various various JJ cord-023584-yaxawqhj 88 27 countries country NNS cord-023584-yaxawqhj 88 28 should should MD cord-023584-yaxawqhj 88 29 be be VB cord-023584-yaxawqhj 88 30 considered consider VBN cord-023584-yaxawqhj 88 31 since since IN cord-023584-yaxawqhj 88 32 these these DT cord-023584-yaxawqhj 88 33 may may MD cord-023584-yaxawqhj 88 34 affect affect VB cord-023584-yaxawqhj 88 35 the the DT cord-023584-yaxawqhj 88 36 prospects prospect NNS cord-023584-yaxawqhj 88 37 for for IN cord-023584-yaxawqhj 88 38 potential potential JJ cord-023584-yaxawqhj 88 39 drugs drug NNS cord-023584-yaxawqhj 88 40 . . . cord-023584-yaxawqhj 89 1 For for IN cord-023584-yaxawqhj 89 2 example example NN cord-023584-yaxawqhj 89 3 , , , cord-023584-yaxawqhj 89 4 in in IN cord-023584-yaxawqhj 89 5 Great Great NNP cord-023584-yaxawqhj 89 6 Britain Britain NNP cord-023584-yaxawqhj 89 7 , , , cord-023584-yaxawqhj 89 8 foot foot NN cord-023584-yaxawqhj 89 9 and and CC cord-023584-yaxawqhj 89 10 mouth mouth NN cord-023584-yaxawqhj 89 11 disease disease NN cord-023584-yaxawqhj 89 12 is be VBZ cord-023584-yaxawqhj 89 13 controlled control VBN cord-023584-yaxawqhj 89 14 by by IN cord-023584-yaxawqhj 89 15 the the DT cord-023584-yaxawqhj 89 16 policy policy NN cord-023584-yaxawqhj 89 17 of of IN cord-023584-yaxawqhj 89 18 slaughter slaughter NN cord-023584-yaxawqhj 89 19 and and CC cord-023584-yaxawqhj 89 20 compensation compensation NN cord-023584-yaxawqhj 89 21 , , , cord-023584-yaxawqhj 89 22 but but CC cord-023584-yaxawqhj 89 23 in in IN cord-023584-yaxawqhj 89 24 other other JJ cord-023584-yaxawqhj 89 25 countries country NNS cord-023584-yaxawqhj 89 26 the the DT cord-023584-yaxawqhj 89 27 disease disease NN cord-023584-yaxawqhj 89 28 is be VBZ cord-023584-yaxawqhj 89 29 controlled control VBN cord-023584-yaxawqhj 89 30 by by IN cord-023584-yaxawqhj 89 31 vaccination vaccination NN cord-023584-yaxawqhj 89 32 . . . cord-023584-yaxawqhj 90 1 In in IN cord-023584-yaxawqhj 90 2 the the DT cord-023584-yaxawqhj 90 3 lattrr lattrr NNP cord-023584-yaxawqhj 90 4 countries country NNS cord-023584-yaxawqhj 90 5 , , , cord-023584-yaxawqhj 90 6 a a DT cord-023584-yaxawqhj 90 7 drug drug NN cord-023584-yaxawqhj 90 8 may may MD cord-023584-yaxawqhj 90 9 find find VB cord-023584-yaxawqhj 90 10 a a DT cord-023584-yaxawqhj 90 11 ready ready JJ cord-023584-yaxawqhj 90 12 market market NN cord-023584-yaxawqhj 90 13 , , , cord-023584-yaxawqhj 90 14 but but CC cord-023584-yaxawqhj 90 15 if if IN cord-023584-yaxawqhj 90 16 legislation legislation NN cord-023584-yaxawqhj 90 17 should should MD cord-023584-yaxawqhj 90 18 change change VB cord-023584-yaxawqhj 90 19 , , , cord-023584-yaxawqhj 90 20 then then RB cord-023584-yaxawqhj 90 21 that that DT cord-023584-yaxawqhj 90 22 market market NN cord-023584-yaxawqhj 90 23 would would MD cord-023584-yaxawqhj 90 24 be be VB cord-023584-yaxawqhj 90 25 lost lose VBN cord-023584-yaxawqhj 90 26 . . . cord-023584-yaxawqhj 91 1 In in IN cord-023584-yaxawqhj 91 2 summary summary NN cord-023584-yaxawqhj 91 3 , , , cord-023584-yaxawqhj 91 4 we -PRON- PRP cord-023584-yaxawqhj 91 5 may may MD cord-023584-yaxawqhj 91 6 say say VB cord-023584-yaxawqhj 91 7 that that IN cord-023584-yaxawqhj 91 8 before before IN cord-023584-yaxawqhj 91 9 embarking embark VBG cord-023584-yaxawqhj 91 10 on on IN cord-023584-yaxawqhj 91 11 a a DT cord-023584-yaxawqhj 91 12 search search NN cord-023584-yaxawqhj 91 13 for for IN cord-023584-yaxawqhj 91 14 antiviral antiviral JJ cord-023584-yaxawqhj 91 15 drugs drug NNS cord-023584-yaxawqhj 91 16 , , , cord-023584-yaxawqhj 91 17 the the DT cord-023584-yaxawqhj 91 18 target target NN cord-023584-yaxawqhj 91 19 disease disease NN cord-023584-yaxawqhj 91 20 must must MD cord-023584-yaxawqhj 91 21 be be VB cord-023584-yaxawqhj 91 22 carefully carefully RB cord-023584-yaxawqhj 91 23 selected select VBN cord-023584-yaxawqhj 91 24 by by IN cord-023584-yaxawqhj 91 25 a a DT cord-023584-yaxawqhj 91 26 consideration consideration NN cord-023584-yaxawqhj 91 27 of of IN cord-023584-yaxawqhj 91 28 all all PDT cord-023584-yaxawqhj 91 29 the the DT cord-023584-yaxawqhj 91 30 relevant relevant JJ cord-023584-yaxawqhj 91 31 factors factor NNS cord-023584-yaxawqhj 91 32 . . . cord-023584-yaxawqhj 92 1 The the DT cord-023584-yaxawqhj 92 2 more more RBR cord-023584-yaxawqhj 92 3 important important JJ cord-023584-yaxawqhj 92 4 of of IN cord-023584-yaxawqhj 92 5 thesc thesc NNP cord-023584-yaxawqhj 92 6 a a DT cord-023584-yaxawqhj 92 7 r r NN cord-023584-yaxawqhj 92 8 t t NN cord-023584-yaxawqhj 92 9 : : : cord-023584-yaxawqhj 92 10 1 1 CD cord-023584-yaxawqhj 92 11 . . . cord-023584-yaxawqhj 93 1 There there EX cord-023584-yaxawqhj 93 2 must must MD cord-023584-yaxawqhj 93 3 be be VB cord-023584-yaxawqhj 93 4 an an DT cord-023584-yaxawqhj 93 5 adequate adequate JJ cord-023584-yaxawqhj 93 6 market market NN cord-023584-yaxawqhj 93 7 for for IN cord-023584-yaxawqhj 93 8 the the DT cord-023584-yaxawqhj 93 9 drug drug NN cord-023584-yaxawqhj 93 10 . . . cord-023584-yaxawqhj 94 1 2 2 LS cord-023584-yaxawqhj 94 2 . . . cord-023584-yaxawqhj 95 1 There there EX cord-023584-yaxawqhj 95 2 should should MD cord-023584-yaxawqhj 95 3 be be VB cord-023584-yaxawqhj 95 4 no no DT cord-023584-yaxawqhj 95 5 effective effective JJ cord-023584-yaxawqhj 95 6 immunological immunological JJ cord-023584-yaxawqhj 95 7 control control NN cord-023584-yaxawqhj 95 8 , , , cord-023584-yaxawqhj 95 9 and and CC cord-023584-yaxawqhj 95 10 no no DT cord-023584-yaxawqhj 95 11 prospects prospect NNS cord-023584-yaxawqhj 95 12 3 3 CD cord-023584-yaxawqhj 95 13 . . . cord-023584-yaxawqhj 96 1 Due due JJ cord-023584-yaxawqhj 96 2 regard regard NN cord-023584-yaxawqhj 96 3 should should MD cord-023584-yaxawqhj 96 4 be be VB cord-023584-yaxawqhj 96 5 given give VBN cord-023584-yaxawqhj 96 6 to to IN cord-023584-yaxawqhj 96 7 the the DT cord-023584-yaxawqhj 96 8 practicability practicability NN cord-023584-yaxawqhj 96 9 and and CC cord-023584-yaxawqhj 96 10 the the DT cord-023584-yaxawqhj 96 11 timing timing NN cord-023584-yaxawqhj 96 12 of of IN cord-023584-yaxawqhj 96 13 4 4 CD cord-023584-yaxawqhj 96 14 . . . cord-023584-yaxawqhj 97 1 The the DT cord-023584-yaxawqhj 97 2 etiology etiology NN cord-023584-yaxawqhj 97 3 of of IN cord-023584-yaxawqhj 97 4 the the DT cord-023584-yaxawqhj 97 5 disease disease NN cord-023584-yaxawqhj 97 6 should should MD cord-023584-yaxawqhj 97 7 be be VB cord-023584-yaxawqhj 97 8 clearly clearly RB cord-023584-yaxawqhj 97 9 established establish VBN cord-023584-yaxawqhj 97 10 . . . cord-023584-yaxawqhj 98 1 Other other JJ cord-023584-yaxawqhj 98 2 relevant relevant JJ cord-023584-yaxawqhj 98 3 factors factor NNS cord-023584-yaxawqhj 98 4 , , , cord-023584-yaxawqhj 98 5 e.g. e.g. RB cord-023584-yaxawqhj 98 6 , , , cord-023584-yaxawqhj 98 7 medical medical JJ cord-023584-yaxawqhj 98 8 or or CC cord-023584-yaxawqhj 98 9 veterinary veterinary JJ cord-023584-yaxawqhj 98 10 legislation legislation NN cord-023584-yaxawqhj 98 11 , , , cord-023584-yaxawqhj 98 12 should should MD cord-023584-yaxawqhj 98 13 be be VB cord-023584-yaxawqhj 98 14 takcn takcn VBN cord-023584-yaxawqhj 98 15 into into IN cord-023584-yaxawqhj 98 16 consideration consideration NN cord-023584-yaxawqhj 98 17 . . . cord-023584-yaxawqhj 99 1 In in IN cord-023584-yaxawqhj 99 2 Table Table NNP cord-023584-yaxawqhj 99 3 I -PRON- PRP cord-023584-yaxawqhj 99 4 , , , cord-023584-yaxawqhj 99 5 a a DT cord-023584-yaxawqhj 99 6 number number NN cord-023584-yaxawqhj 99 7 of of IN cord-023584-yaxawqhj 99 8 virus virus NN cord-023584-yaxawqhj 99 9 diseases disease NNS cord-023584-yaxawqhj 99 10 of of IN cord-023584-yaxawqhj 99 11 economic economic JJ cord-023584-yaxawqhj 99 12 importance importance NN cord-023584-yaxawqhj 99 13 are be VBP cord-023584-yaxawqhj 99 14 listed list VBN cord-023584-yaxawqhj 99 15 together together RB cord-023584-yaxawqhj 99 16 with with IN cord-023584-yaxawqhj 99 17 some some DT cord-023584-yaxawqhj 99 18 comments comment NNS cord-023584-yaxawqhj 99 19 to to TO cord-023584-yaxawqhj 99 20 illustrate illustrate VB cord-023584-yaxawqhj 99 21 how how WRB cord-023584-yaxawqhj 99 22 many many JJ cord-023584-yaxawqhj 99 23 seemingly seemingly RB cord-023584-yaxawqhj 99 24 attractive attractive JJ cord-023584-yaxawqhj 99 25 drug drug NN cord-023584-yaxawqhj 99 26 - - HYPH cord-023584-yaxawqhj 99 27 target target NN cord-023584-yaxawqhj 99 28 diseases disease NNS cord-023584-yaxawqhj 99 29 are be VBP cord-023584-yaxawqhj 99 30 in in IN cord-023584-yaxawqhj 99 31 fact fact NN cord-023584-yaxawqhj 99 32 precluded preclude VBN cord-023584-yaxawqhj 99 33 by by IN cord-023584-yaxawqhj 99 34 other other JJ cord-023584-yaxawqhj 99 35 factors factor NNS cord-023584-yaxawqhj 99 36 . . . cord-023584-yaxawqhj 100 1 for for IN cord-023584-yaxawqhj 100 2 such such JJ cord-023584-yaxawqhj 100 3 control control NN cord-023584-yaxawqhj 100 4 . . . cord-023584-yaxawqhj 101 1 dosing dose VBG cord-023584-yaxawqhj 101 2 the the DT cord-023584-yaxawqhj 101 3 patients patient NNS cord-023584-yaxawqhj 101 4 or or CC cord-023584-yaxawqhj 101 5 animals animal NNS cord-023584-yaxawqhj 101 6 at at IN cord-023584-yaxawqhj 101 7 risk risk NN cord-023584-yaxawqhj 101 8 . . . cord-023584-yaxawqhj 102 1 It -PRON- PRP cord-023584-yaxawqhj 102 2 is be VBZ cord-023584-yaxawqhj 102 3 easy easy JJ cord-023584-yaxawqhj 102 4 to to TO cord-023584-yaxawqhj 102 5 list list VB cord-023584-yaxawqhj 102 6 the the DT cord-023584-yaxawqhj 102 7 properties property NNS cord-023584-yaxawqhj 102 8 of of IN cord-023584-yaxawqhj 102 9 the the DT cord-023584-yaxawqhj 102 10 ideal ideal JJ cord-023584-yaxawqhj 102 11 antiviral antiviral JJ cord-023584-yaxawqhj 102 12 drug drug NN cord-023584-yaxawqhj 102 13 - - HYPH cord-023584-yaxawqhj 102 14 wide wide JJ cord-023584-yaxawqhj 102 15 spectrum spectrum NN cord-023584-yaxawqhj 102 16 of of IN cord-023584-yaxawqhj 102 17 activity activity NN cord-023584-yaxawqhj 102 18 , , , cord-023584-yaxawqhj 102 19 nontoxic nontoxic JJ cord-023584-yaxawqhj 102 20 , , , cord-023584-yaxawqhj 102 21 accessible accessible JJ cord-023584-yaxawqhj 102 22 to to IN cord-023584-yaxawqhj 102 23 the the DT cord-023584-yaxawqhj 102 24 target target NN cord-023584-yaxawqhj 102 25 organ organ NN cord-023584-yaxawqhj 102 26 , , , cord-023584-yaxawqhj 102 27 etc etc FW cord-023584-yaxawqhj 102 28 . . . cord-023584-yaxawqhj 103 1 What what WP cord-023584-yaxawqhj 103 2 is be VBZ cord-023584-yaxawqhj 103 3 not not RB cord-023584-yaxawqhj 103 4 so so RB cord-023584-yaxawqhj 103 5 easy easy JJ cord-023584-yaxawqhj 103 6 is be VBZ cord-023584-yaxawqhj 103 7 to to TO cord-023584-yaxawqhj 103 8 predict predict VB cord-023584-yaxawqhj 103 9 what what WP cord-023584-yaxawqhj 103 10 sort sort NN cord-023584-yaxawqhj 103 11 of of IN cord-023584-yaxawqhj 103 12 properties property NNS cord-023584-yaxawqhj 103 13 one one PRP cord-023584-yaxawqhj 103 14 might may MD cord-023584-yaxawqhj 103 15 expect expect VB cord-023584-yaxawqhj 103 16 from from IN cord-023584-yaxawqhj 103 17 antiviral antiviral JJ cord-023584-yaxawqhj 103 18 leads lead NNS cord-023584-yaxawqhj 103 19 detected detect VBN cord-023584-yaxawqhj 103 20 by by IN cord-023584-yaxawqhj 103 21 screening screen VBG cord-023584-yaxawqhj 103 22 programs program NNS cord-023584-yaxawqhj 103 23 . . . cord-023584-yaxawqhj 104 1 All all PDT cord-023584-yaxawqhj 104 2 the the DT cord-023584-yaxawqhj 104 3 same same JJ cord-023584-yaxawqhj 104 4 , , , cord-023584-yaxawqhj 104 5 it -PRON- PRP cord-023584-yaxawqhj 104 6 is be VBZ cord-023584-yaxawqhj 104 7 only only RB cord-023584-yaxawqhj 104 8 by by IN cord-023584-yaxawqhj 104 9 intelligent intelligent JJ cord-023584-yaxawqhj 104 10 attempts attempt NNS cord-023584-yaxawqhj 104 11 to to TO cord-023584-yaxawqhj 104 12 do do VB cord-023584-yaxawqhj 104 13 just just RB cord-023584-yaxawqhj 104 14 this this DT cord-023584-yaxawqhj 104 15 that that IN cord-023584-yaxawqhj 104 16 screens screen NNS cord-023584-yaxawqhj 104 17 may may MD cord-023584-yaxawqhj 104 18 be be VB cord-023584-yaxawqhj 104 19 designed design VBN cord-023584-yaxawqhj 104 20 to to TO cord-023584-yaxawqhj 104 21 detect detect VB cord-023584-yaxawqhj 104 22 compounds compound NNS cord-023584-yaxawqhj 104 23 that that WDT cord-023584-yaxawqhj 104 24 one one CD cord-023584-yaxawqhj 104 25 day day NN cord-023584-yaxawqhj 104 26 may may MD cord-023584-yaxawqhj 104 27 lead lead VB cord-023584-yaxawqhj 104 28 to to IN cord-023584-yaxawqhj 104 29 the the DT cord-023584-yaxawqhj 104 30 development development NN cord-023584-yaxawqhj 104 31 of of IN cord-023584-yaxawqhj 104 32 useful useful JJ cord-023584-yaxawqhj 104 33 medicines medicine NNS cord-023584-yaxawqhj 104 34 . . . cord-023584-yaxawqhj 105 1 The the DT cord-023584-yaxawqhj 105 2 scientific scientific JJ cord-023584-yaxawqhj 105 3 literature literature NN cord-023584-yaxawqhj 105 4 abounds abound VBZ cord-023584-yaxawqhj 105 5 with with IN cord-023584-yaxawqhj 105 6 reports report NNS cord-023584-yaxawqhj 105 7 of of IN cord-023584-yaxawqhj 105 8 antiviral antiviral JJ cord-023584-yaxawqhj 105 9 chemicals chemical NNS cord-023584-yaxawqhj 105 10 discovered discover VBN cord-023584-yaxawqhj 105 11 by by IN cord-023584-yaxawqhj 105 12 screening screen VBG cord-023584-yaxawqhj 105 13 random random JJ cord-023584-yaxawqhj 105 14 compounds compound NNS cord-023584-yaxawqhj 105 15 in in IN cord-023584-yaxawqhj 105 16 tissue tissue NN cord-023584-yaxawqhj 105 17 culture culture NN cord-023584-yaxawqhj 105 18 systems system NNS cord-023584-yaxawqhj 105 19 , , , cord-023584-yaxawqhj 105 20 but but CC cord-023584-yaxawqhj 105 21 all all DT cord-023584-yaxawqhj 105 22 too too RB cord-023584-yaxawqhj 105 23 frequently frequently RB cord-023584-yaxawqhj 105 24 these these DT cord-023584-yaxawqhj 105 25 compounds compound NNS cord-023584-yaxawqhj 105 26 turn turn VBP cord-023584-yaxawqhj 105 27 out out RP cord-023584-yaxawqhj 105 28 to to TO cord-023584-yaxawqhj 105 29 be be VB cord-023584-yaxawqhj 105 30 false false JJ cord-023584-yaxawqhj 105 31 positives positive NNS cord-023584-yaxawqhj 105 32 or or CC cord-023584-yaxawqhj 105 33 active active JJ cord-023584-yaxawqhj 105 34 only only RB cord-023584-yaxawqhj 105 35 against against IN cord-023584-yaxawqhj 105 36 some some DT cord-023584-yaxawqhj 105 37 relatively relatively RB cord-023584-yaxawqhj 105 38 unimportant unimportant JJ cord-023584-yaxawqhj 105 39 virus virus NN cord-023584-yaxawqhj 105 40 . . . cord-023584-yaxawqhj 106 1 For for IN cord-023584-yaxawqhj 106 2 the the DT cord-023584-yaxawqhj 106 3 products product NNS cord-023584-yaxawqhj 106 4 of of IN cord-023584-yaxawqhj 106 5 a a DT cord-023584-yaxawqhj 106 6 tissue tissue NN cord-023584-yaxawqhj 106 7 culture culture NN cord-023584-yaxawqhj 106 8 screen screen NN cord-023584-yaxawqhj 106 9 to to TO cord-023584-yaxawqhj 106 10 be be VB cord-023584-yaxawqhj 106 11 of of IN cord-023584-yaxawqhj 106 12 potential potential JJ cord-023584-yaxawqhj 106 13 value value NN cord-023584-yaxawqhj 106 14 , , , cord-023584-yaxawqhj 106 15 the the DT cord-023584-yaxawqhj 106 16 screen screen NN cord-023584-yaxawqhj 106 17 must must MD cord-023584-yaxawqhj 106 18 meet meet VB cord-023584-yaxawqhj 106 19 the the DT cord-023584-yaxawqhj 106 20 requirements requirement NNS cord-023584-yaxawqhj 106 21 outlined outline VBN cord-023584-yaxawqhj 106 22 below below RB cord-023584-yaxawqhj 106 23 . . . cord-023584-yaxawqhj 107 1 First first RB cord-023584-yaxawqhj 107 2 , , , cord-023584-yaxawqhj 107 3 the the DT cord-023584-yaxawqhj 107 4 screen screen NN cord-023584-yaxawqhj 107 5 should should MD cord-023584-yaxawqhj 107 6 be be VB cord-023584-yaxawqhj 107 7 able able JJ cord-023584-yaxawqhj 107 8 to to TO cord-023584-yaxawqhj 107 9 process process VB cord-023584-yaxawqhj 107 10 large large JJ cord-023584-yaxawqhj 107 11 numbers number NNS cord-023584-yaxawqhj 107 12 of of IN cord-023584-yaxawqhj 107 13 chemical chemical JJ cord-023584-yaxawqhj 107 14 compounds compound NNS cord-023584-yaxawqhj 107 15 , , , cord-023584-yaxawqhj 107 16 or or CC cord-023584-yaxawqhj 107 17 fermentation fermentation NN cord-023584-yaxawqhj 107 18 products product NNS cord-023584-yaxawqhj 107 19 , , , cord-023584-yaxawqhj 107 20 since since IN cord-023584-yaxawqhj 107 21 the the DT cord-023584-yaxawqhj 107 22 more more JJR cord-023584-yaxawqhj 107 23 that that WDT cord-023584-yaxawqhj 107 24 are be VBP cord-023584-yaxawqhj 107 25 tested test VBN cord-023584-yaxawqhj 107 26 , , , cord-023584-yaxawqhj 107 27 the the DT cord-023584-yaxawqhj 107 28 greater great JJR cord-023584-yaxawqhj 107 29 the the DT cord-023584-yaxawqhj 107 30 chance chance NN cord-023584-yaxawqhj 107 31 of of IN cord-023584-yaxawqhj 107 32 success success NN cord-023584-yaxawqhj 107 33 in in IN cord-023584-yaxawqhj 107 34 finding find VBG cord-023584-yaxawqhj 107 35 active active JJ cord-023584-yaxawqhj 107 36 leads lead NNS cord-023584-yaxawqhj 107 37 . . . cord-023584-yaxawqhj 108 1 Perhaps perhaps RB cord-023584-yaxawqhj 108 2 the the DT cord-023584-yaxawqhj 108 3 time time NN cord-023584-yaxawqhj 108 4 will will MD cord-023584-yaxawqhj 108 5 come come VB cord-023584-yaxawqhj 108 6 when when WRB cord-023584-yaxawqhj 108 7 new new JJ cord-023584-yaxawqhj 108 8 drugs drug NNS cord-023584-yaxawqhj 108 9 can can MD cord-023584-yaxawqhj 108 10 be be VB cord-023584-yaxawqhj 108 11 designed design VBN cord-023584-yaxawqhj 108 12 and and CC cord-023584-yaxawqhj 108 13 synthesized synthesize VBN cord-023584-yaxawqhj 108 14 on on IN cord-023584-yaxawqhj 108 15 entirely entirely RB cord-023584-yaxawqhj 108 16 rational rational JJ cord-023584-yaxawqhj 108 17 grounds ground NNS cord-023584-yaxawqhj 108 18 , , , cord-023584-yaxawqhj 108 19 but but CC cord-023584-yaxawqhj 108 20 at at IN cord-023584-yaxawqhj 108 21 present present JJ cord-023584-yaxawqhj 108 22 most most JJS cord-023584-yaxawqhj 108 23 active active JJ cord-023584-yaxawqhj 108 24 leads lead NNS cord-023584-yaxawqhj 108 25 are be VBP cord-023584-yaxawqhj 108 26 chance chance NN cord-023584-yaxawqhj 108 27 discoveries discovery NNS cord-023584-yaxawqhj 108 28 . . . cord-023584-yaxawqhj 109 1 Buthala Buthala NNP cord-023584-yaxawqhj 109 2 ( ( -LRB- cord-023584-yaxawqhj 109 3 1965 1965 CD cord-023584-yaxawqhj 109 4 ) ) -RRB- cord-023584-yaxawqhj 109 5 quotes quote VBZ cord-023584-yaxawqhj 109 6 6 6 CD cord-023584-yaxawqhj 109 7 % % NN cord-023584-yaxawqhj 109 8 of of IN cord-023584-yaxawqhj 109 9 all all DT cord-023584-yaxawqhj 109 10 compounds compound NNS cord-023584-yaxawqhj 109 11 tested test VBN cord-023584-yaxawqhj 109 12 in in IN cord-023584-yaxawqhj 109 13 a a DT cord-023584-yaxawqhj 109 14 tissue tissue NN cord-023584-yaxawqhj 109 15 screen screen NN cord-023584-yaxawqhj 109 16 as as IN cord-023584-yaxawqhj 109 17 showing show VBG cord-023584-yaxawqhj 109 18 some some DT cord-023584-yaxawqhj 109 19 antiviral antiviral JJ cord-023584-yaxawqhj 109 20 activity activity NN cord-023584-yaxawqhj 109 21 , , , cord-023584-yaxawqhj 109 22 but but CC cord-023584-yaxawqhj 109 23 in in IN cord-023584-yaxawqhj 109 24 my -PRON- PRP$ cord-023584-yaxawqhj 109 25 experience experience NN cord-023584-yaxawqhj 109 26 the the DT cord-023584-yaxawqhj 109 27 rate rate NN cord-023584-yaxawqhj 109 28 varies vary VBZ cord-023584-yaxawqhj 109 29 from from IN cord-023584-yaxawqhj 109 30 1 1 CD cord-023584-yaxawqhj 109 31 to to IN cord-023584-yaxawqhj 109 32 O.Ol$ O.Ol$ NNP cord-023584-yaxawqhj 109 33 ! ! . cord-023584-yaxawqhj 110 1 & & CC cord-023584-yaxawqhj 110 2 , , , cord-023584-yaxawqhj 110 3 the the DT cord-023584-yaxawqhj 110 4 higher high JJR cord-023584-yaxawqhj 110 5 rate rate NN cord-023584-yaxawqhj 110 6 referring refer VBG cord-023584-yaxawqhj 110 7 to to IN cord-023584-yaxawqhj 110 8 influenza influenza VB cord-023584-yaxawqhj 110 9 A a DT cord-023584-yaxawqhj 110 10 viruses virus NNS cord-023584-yaxawqhj 110 11 , , , cord-023584-yaxawqhj 110 12 and and CC cord-023584-yaxawqhj 110 13 the the DT cord-023584-yaxawqhj 110 14 lower low JJR cord-023584-yaxawqhj 110 15 rate rate NN cord-023584-yaxawqhj 110 16 to to IN cord-023584-yaxawqhj 110 17 picornaviruses picornavirus NNS cord-023584-yaxawqhj 110 18 . . . cord-023584-yaxawqhj 111 1 Bauer Bauer NNP cord-023584-yaxawqhj 111 2 ( ( -LRB- cord-023584-yaxawqhj 111 3 1967 1967 CD cord-023584-yaxawqhj 111 4 ) ) -RRB- cord-023584-yaxawqhj 111 5 has have VBZ cord-023584-yaxawqhj 111 6 suggested suggest VBN cord-023584-yaxawqhj 111 7 that that IN cord-023584-yaxawqhj 111 8 the the DT cord-023584-yaxawqhj 111 9 larger large JJR cord-023584-yaxawqhj 111 10 the the DT cord-023584-yaxawqhj 111 11 virus virus NN cord-023584-yaxawqhj 111 12 , , , cord-023584-yaxawqhj 111 13 the the DT cord-023584-yaxawqhj 111 14 more more RBR cord-023584-yaxawqhj 111 15 susceptible susceptible JJ cord-023584-yaxawqhj 111 16 it -PRON- PRP cord-023584-yaxawqhj 111 17 is be VBZ cord-023584-yaxawqhj 111 18 to to IN cord-023584-yaxawqhj 111 19 inhibition inhibition NN cord-023584-yaxawqhj 111 20 , , , cord-023584-yaxawqhj 111 21 since since IN cord-023584-yaxawqhj 111 22 , , , cord-023584-yaxawqhj 111 23 for for IN cord-023584-yaxawqhj 111 24 any any DT cord-023584-yaxawqhj 111 25 given give VBN cord-023584-yaxawqhj 111 26 intracellular intracellular JJ cord-023584-yaxawqhj 111 27 concentration concentration NN cord-023584-yaxawqhj 111 28 of of IN cord-023584-yaxawqhj 111 29 drug drug NN cord-023584-yaxawqhj 111 30 , , , cord-023584-yaxawqhj 111 31 a a DT cord-023584-yaxawqhj 111 32 large large JJ cord-023584-yaxawqhj 111 33 virus virus NN cord-023584-yaxawqhj 111 34 will will MD cord-023584-yaxawqhj 111 35 encompass encompass VB cord-023584-yaxawqhj 111 36 , , , cord-023584-yaxawqhj 111 37 both both CC cord-023584-yaxawqhj 111 38 physically physically RB cord-023584-yaxawqhj 111 39 and and CC cord-023584-yaxawqhj 111 40 in in IN cord-023584-yaxawqhj 111 41 terms term NNS cord-023584-yaxawqhj 111 42 of of IN cord-023584-yaxawqhj 111 43 synthetic synthetic JJ cord-023584-yaxawqhj 111 44 requirements requirement NNS cord-023584-yaxawqhj 111 45 , , , cord-023584-yaxawqhj 111 46 more more JJR cord-023584-yaxawqhj 111 47 drug drug NN cord-023584-yaxawqhj 111 48 molecules molecule NNS cord-023584-yaxawqhj 111 49 than than IN cord-023584-yaxawqhj 111 50 a a DT cord-023584-yaxawqhj 111 51 small small JJ cord-023584-yaxawqhj 111 52 one one CD cord-023584-yaxawqhj 111 53 . . . cord-023584-yaxawqhj 112 1 Undoubtedly undoubtedly RB cord-023584-yaxawqhj 112 2 , , , cord-023584-yaxawqhj 112 3 this this DT cord-023584-yaxawqhj 112 4 principle principle NN cord-023584-yaxawqhj 112 5 will will MD cord-023584-yaxawqhj 112 6 contribute contribute VB cord-023584-yaxawqhj 112 7 to to IN cord-023584-yaxawqhj 112 8 our -PRON- PRP$ cord-023584-yaxawqhj 112 9 observed observed JJ cord-023584-yaxawqhj 112 10 high high JJ cord-023584-yaxawqhj 112 11 rate rate NN cord-023584-yaxawqhj 112 12 of of IN cord-023584-yaxawqhj 112 13 inhibition inhibition NN cord-023584-yaxawqhj 112 14 of of IN cord-023584-yaxawqhj 112 15 influenza influenza NN cord-023584-yaxawqhj 112 16 virus virus NN cord-023584-yaxawqhj 112 17 , , , cord-023584-yaxawqhj 112 18 but but CC cord-023584-yaxawqhj 112 19 another another DT cord-023584-yaxawqhj 112 20 important important JJ cord-023584-yaxawqhj 112 21 factor factor NN cord-023584-yaxawqhj 112 22 seems seem VBZ cord-023584-yaxawqhj 112 23 to to TO cord-023584-yaxawqhj 112 24 be be VB cord-023584-yaxawqhj 112 25 that that IN cord-023584-yaxawqhj 112 26 the the DT cord-023584-yaxawqhj 112 27 adsorption adsorption NN cord-023584-yaxawqhj 112 28 of of IN cord-023584-yaxawqhj 112 29 influenza influenza NN cord-023584-yaxawqhj 112 30 viruses virus NNS cord-023584-yaxawqhj 112 31 to to IN cord-023584-yaxawqhj 112 32 cellular cellular JJ cord-023584-yaxawqhj 112 33 receptors receptor NNS cord-023584-yaxawqhj 112 34 is be VBZ cord-023584-yaxawqhj 112 35 particularly particularly RB cord-023584-yaxawqhj 112 36 vulnerable vulnerable JJ cord-023584-yaxawqhj 112 37 to to IN cord-023584-yaxawqhj 112 38 interference interference NN cord-023584-yaxawqhj 112 39 by by IN cord-023584-yaxawqhj 112 40 extraneous extraneous JJ cord-023584-yaxawqhj 112 41 substances substance NNS cord-023584-yaxawqhj 112 42 . . . cord-023584-yaxawqhj 113 1 Given give VBN cord-023584-yaxawqhj 113 2 that that IN cord-023584-yaxawqhj 113 3 only only RB cord-023584-yaxawqhj 113 4 a a DT cord-023584-yaxawqhj 113 5 fraction fraction NN cord-023584-yaxawqhj 113 6 of of IN cord-023584-yaxawqhj 113 7 a a DT cord-023584-yaxawqhj 113 8 percent percent NN cord-023584-yaxawqhj 113 9 of of IN cord-023584-yaxawqhj 113 10 all all DT cord-023584-yaxawqhj 113 11 compounds compound NNS cord-023584-yaxawqhj 113 12 tested test VBN cord-023584-yaxawqhj 113 13 in in IN cord-023584-yaxawqhj 113 14 tissue tissue NN cord-023584-yaxawqhj 113 15 culture culture NN cord-023584-yaxawqhj 113 16 will will MD cord-023584-yaxawqhj 113 17 show show VB cord-023584-yaxawqhj 113 18 activity activity NN cord-023584-yaxawqhj 113 19 and and CC cord-023584-yaxawqhj 113 20 that that DT cord-023584-yaxawqhj 113 21 of of IN cord-023584-yaxawqhj 113 22 these these DT cord-023584-yaxawqhj 113 23 only only RB cord-023584-yaxawqhj 113 24 a a DT cord-023584-yaxawqhj 113 25 small small JJ cord-023584-yaxawqhj 113 26 proportion proportion NN cord-023584-yaxawqhj 113 27 will will MD cord-023584-yaxawqhj 113 28 show show VB cord-023584-yaxawqhj 113 29 activity activity NN cord-023584-yaxawqhj 113 30 in in IN cord-023584-yaxawqhj 113 31 animal animal NN cord-023584-yaxawqhj 113 32 models model NNS cord-023584-yaxawqhj 113 33 , , , cord-023584-yaxawqhj 113 34 a a DT cord-023584-yaxawqhj 113 35 realistic realistic JJ cord-023584-yaxawqhj 113 36 screening screening NN cord-023584-yaxawqhj 113 37 rate rate NN cord-023584-yaxawqhj 113 38 would would MD cord-023584-yaxawqhj 113 39 be be VB cord-023584-yaxawqhj 113 40 not not RB cord-023584-yaxawqhj 113 41 less less JJR cord-023584-yaxawqhj 113 42 than than IN cord-023584-yaxawqhj 113 43 5000 5000 CD cord-023584-yaxawqhj 113 44 compounds compound NNS cord-023584-yaxawqhj 113 45 a a DT cord-023584-yaxawqhj 113 46 year year NN cord-023584-yaxawqhj 113 47 . . . cord-023584-yaxawqhj 114 1 At at IN cord-023584-yaxawqhj 114 2 rates rate NNS cord-023584-yaxawqhj 114 3 less less JJR cord-023584-yaxawqhj 114 4 than than IN cord-023584-yaxawqhj 114 5 this this DT cord-023584-yaxawqhj 114 6 , , , cord-023584-yaxawqhj 114 7 the the DT cord-023584-yaxawqhj 114 8 chances chance NNS cord-023584-yaxawqhj 114 9 of of IN cord-023584-yaxawqhj 114 10 finding find VBG cord-023584-yaxawqhj 114 11 useful useful JJ cord-023584-yaxawqhj 114 12 compounds compound NNS cord-023584-yaxawqhj 114 13 become become VBP cord-023584-yaxawqhj 114 14 so so RB cord-023584-yaxawqhj 114 15 small small JJ cord-023584-yaxawqhj 114 16 as as IN cord-023584-yaxawqhj 114 17 to to TO cord-023584-yaxawqhj 114 18 make make VB cord-023584-yaxawqhj 114 19 the the DT cord-023584-yaxawqhj 114 20 whole whole JJ cord-023584-yaxawqhj 114 21 project project NN cord-023584-yaxawqhj 114 22 not not RB cord-023584-yaxawqhj 114 23 worthwhile worthwhile JJ cord-023584-yaxawqhj 114 24 . . . cord-023584-yaxawqhj 115 1 In in IN cord-023584-yaxawqhj 115 2 many many JJ cord-023584-yaxawqhj 115 3 of of IN cord-023584-yaxawqhj 115 4 the the DT cord-023584-yaxawqhj 115 5 published publish VBN cord-023584-yaxawqhj 115 6 screening screening NN cord-023584-yaxawqhj 115 7 procedures procedure NNS cord-023584-yaxawqhj 115 8 , , , cord-023584-yaxawqhj 115 9 the the DT cord-023584-yaxawqhj 115 10 virus virus NN cord-023584-yaxawqhj 115 11 with with IN cord-023584-yaxawqhj 115 12 which which WDT cord-023584-yaxawqhj 115 13 the the DT cord-023584-yaxawqhj 115 14 screens screen NNS cord-023584-yaxawqhj 115 15 are be VBP cord-023584-yaxawqhj 115 16 run run VBN cord-023584-yaxawqhj 115 17 seem seem VBP cord-023584-yaxawqhj 115 18 to to TO cord-023584-yaxawqhj 115 19 have have VB cord-023584-yaxawqhj 115 20 been be VBN cord-023584-yaxawqhj 115 21 chosen choose VBN cord-023584-yaxawqhj 115 22 more more RBR cord-023584-yaxawqhj 115 23 for for IN cord-023584-yaxawqhj 115 24 the the DT cord-023584-yaxawqhj 115 25 ease ease NN cord-023584-yaxawqhj 115 26 with with IN cord-023584-yaxawqhj 115 27 which which WDT cord-023584-yaxawqhj 115 28 they -PRON- PRP cord-023584-yaxawqhj 115 29 can can MD cord-023584-yaxawqhj 115 30 be be VB cord-023584-yaxawqhj 115 31 handled handle VBN cord-023584-yaxawqhj 115 32 rather rather RB cord-023584-yaxawqhj 115 33 than than IN cord-023584-yaxawqhj 115 34 for for IN cord-023584-yaxawqhj 115 35 their -PRON- PRP$ cord-023584-yaxawqhj 115 36 relevance relevance NN cord-023584-yaxawqhj 115 37 to to IN cord-023584-yaxawqhj 115 38 any any DT cord-023584-yaxawqhj 115 39 virus virus NN cord-023584-yaxawqhj 115 40 disease disease NN cord-023584-yaxawqhj 115 41 target target NN cord-023584-yaxawqhj 115 42 . . . cord-023584-yaxawqhj 116 1 For for IN cord-023584-yaxawqhj 116 2 example example NN cord-023584-yaxawqhj 116 3 , , , cord-023584-yaxawqhj 116 4 Ehrlich Ehrlich NNP cord-023584-yaxawqhj 116 5 et et NNP cord-023584-yaxawqhj 116 6 al al NNP cord-023584-yaxawqhj 116 7 . . . cord-023584-yaxawqhj 117 1 ( ( -LRB- cord-023584-yaxawqhj 117 2 1965 1965 CD cord-023584-yaxawqhj 117 3 ) ) -RRB- cord-023584-yaxawqhj 117 4 describes describe VBZ cord-023584-yaxawqhj 117 5 a a DT cord-023584-yaxawqhj 117 6 screen screen NN cord-023584-yaxawqhj 117 7 where where WRB cord-023584-yaxawqhj 117 8 the the DT cord-023584-yaxawqhj 117 9 primary primary JJ cord-023584-yaxawqhj 117 10 test test NN cord-023584-yaxawqhj 117 11 viruses virus NNS cord-023584-yaxawqhj 117 12 include include VBP cord-023584-yaxawqhj 117 13 parainfluenza parainfluenza NNP cord-023584-yaxawqhj 117 14 type type NNP cord-023584-yaxawqhj 117 15 3 3 CD cord-023584-yaxawqhj 117 16 , , , cord-023584-yaxawqhj 117 17 measles measle NNS cord-023584-yaxawqhj 117 18 , , , cord-023584-yaxawqhj 117 19 and and CC cord-023584-yaxawqhj 117 20 poliovirus poliovirus NN cord-023584-yaxawqhj 117 21 , , , cord-023584-yaxawqhj 117 22 and and CC cord-023584-yaxawqhj 117 23 Johnson Johnson NNP cord-023584-yaxawqhj 117 24 ( ( -LRB- cord-023584-yaxawqhj 117 25 1965 1965 CD cord-023584-yaxawqhj 117 26 ) ) -RRB- cord-023584-yaxawqhj 117 27 describes describe VBZ cord-023584-yaxawqhj 117 28 a a DT cord-023584-yaxawqhj 117 29 screen screen NN cord-023584-yaxawqhj 117 30 that that WDT cord-023584-yaxawqhj 117 31 includes include VBZ cord-023584-yaxawqhj 117 32 pseudorabies pseudorabies NN cord-023584-yaxawqhj 117 33 , , , cord-023584-yaxawqhj 117 34 adenovirus adenovirus NN cord-023584-yaxawqhj 117 35 111 111 CD cord-023584-yaxawqhj 117 36 , , , cord-023584-yaxawqhj 117 37 and and CC cord-023584-yaxawqhj 117 38 mouse mouse NN cord-023584-yaxawqhj 117 39 hepatitis hepatitis NNP cord-023584-yaxawqhj 117 40 virus virus NN cord-023584-yaxawqhj 117 41 . . . cord-023584-yaxawqhj 118 1 Of of RB cord-023584-yaxawqhj 118 2 course course RB cord-023584-yaxawqhj 118 3 , , , cord-023584-yaxawqhj 118 4 if if IN cord-023584-yaxawqhj 118 5 wide wide JJ cord-023584-yaxawqhj 118 6 - - HYPH cord-023584-yaxawqhj 118 7 spectrum spectrum NN cord-023584-yaxawqhj 118 8 leads lead NNS cord-023584-yaxawqhj 118 9 appear appear VBP cord-023584-yaxawqhj 118 10 , , , cord-023584-yaxawqhj 118 11 the the DT cord-023584-yaxawqhj 118 12 choice choice NN cord-023584-yaxawqhj 118 13 of of IN cord-023584-yaxawqhj 118 14 test test NN cord-023584-yaxawqhj 118 15 virus virus NN cord-023584-yaxawqhj 118 16 may may MD cord-023584-yaxawqhj 118 17 be be VB cord-023584-yaxawqhj 118 18 irrelevant irrelevant JJ cord-023584-yaxawqhj 118 19 , , , cord-023584-yaxawqhj 118 20 but but CC cord-023584-yaxawqhj 118 21 the the DT cord-023584-yaxawqhj 118 22 antiviral antiviral JJ cord-023584-yaxawqhj 118 23 compounds compound NNS cord-023584-yaxawqhj 118 24 ( ( -LRB- cord-023584-yaxawqhj 118 25 as as IN cord-023584-yaxawqhj 118 26 distinct distinct JJ cord-023584-yaxawqhj 118 27 from from IN cord-023584-yaxawqhj 118 28 interferon interferon NN cord-023584-yaxawqhj 118 29 inducers inducer NNS cord-023584-yaxawqhj 118 30 ) ) -RRB- cord-023584-yaxawqhj 118 31 known know VBN cord-023584-yaxawqhj 118 32 at at IN cord-023584-yaxawqhj 118 33 present present JJ cord-023584-yaxawqhj 118 34 are be VBP cord-023584-yaxawqhj 118 35 characterized characterize VBN cord-023584-yaxawqhj 118 36 by by IN cord-023584-yaxawqhj 118 37 their -PRON- PRP$ cord-023584-yaxawqhj 118 38 relatively relatively RB cord-023584-yaxawqhj 118 39 limited limited JJ cord-023584-yaxawqhj 118 40 spectrum spectrum NN cord-023584-yaxawqhj 118 41 of of IN cord-023584-yaxawqhj 118 42 activity activity NN cord-023584-yaxawqhj 118 43 , , , cord-023584-yaxawqhj 118 44 e.g. e.g. RB cord-023584-yaxawqhj 118 45 , , , cord-023584-yaxawqhj 118 46 methisazone methisazone NNP cord-023584-yaxawqhj 118 47 is be VBZ cord-023584-yaxawqhj 118 48 active active JJ cord-023584-yaxawqhj 118 49 only only RB cord-023584-yaxawqhj 118 50 against against IN cord-023584-yaxawqhj 118 51 poxviruses poxvirus NNS cord-023584-yaxawqhj 118 52 ( ( -LRB- cord-023584-yaxawqhj 118 53 Bauer Bauer NNP cord-023584-yaxawqhj 118 54 and and CC cord-023584-yaxawqhj 118 55 Sadler Sadler NNP cord-023584-yaxawqhj 118 56 , , , cord-023584-yaxawqhj 118 57 1960 1960 CD cord-023584-yaxawqhj 118 58 ) ) -RRB- cord-023584-yaxawqhj 118 59 and and CC cord-023584-yaxawqhj 118 60 possibly possibly RB cord-023584-yaxawqhj 118 61 adenoviruses adenovirus NNS cord-023584-yaxawqhj 118 62 ( ( -LRB- cord-023584-yaxawqhj 118 63 Bauer Bauer NNP cord-023584-yaxawqhj 118 64 and and CC cord-023584-yaxawqhj 118 65 Apostolov Apostolov NNP cord-023584-yaxawqhj 118 66 , , , cord-023584-yaxawqhj 118 67 1966 1966 CD cord-023584-yaxawqhj 118 68 ) ) -RRB- cord-023584-yaxawqhj 118 69 ; ; : cord-023584-yaxawqhj 118 70 l l NN cord-023584-yaxawqhj 118 71 - - HYPH cord-023584-yaxawqhj 118 72 aminoadamantane aminoadamantane NNP cord-023584-yaxawqhj 118 73 is be VBZ cord-023584-yaxawqhj 118 74 active active JJ cord-023584-yaxawqhj 118 75 only only RB cord-023584-yaxawqhj 118 76 against against IN cord-023584-yaxawqhj 118 77 influenza influenza NN cord-023584-yaxawqhj 118 78 A1 A1 NNP cord-023584-yaxawqhj 118 79 and and CC cord-023584-yaxawqhj 118 80 As as IN cord-023584-yaxawqhj 118 81 and and CC cord-023584-yaxawqhj 118 82 not not RB cord-023584-yaxawqhj 118 83 against against IN cord-023584-yaxawqhj 118 84 other other JJ cord-023584-yaxawqhj 118 85 myxo myxo NN cord-023584-yaxawqhj 118 86 - - HYPH cord-023584-yaxawqhj 118 87 or or CC cord-023584-yaxawqhj 118 88 paramyxoviruses paramyxovirus NNS cord-023584-yaxawqhj 119 1 ( ( -LRB- cord-023584-yaxawqhj 119 2 Davies Davies NNP cord-023584-yaxawqhj 119 3 et et NNP cord-023584-yaxawqhj 119 4 al al NNP cord-023584-yaxawqhj 119 5 . . NNP cord-023584-yaxawqhj 119 6 , , , cord-023584-yaxawqhj 119 7 1964 1964 CD cord-023584-yaxawqhj 119 8 ) ) -RRB- cord-023584-yaxawqhj 119 9 ; ; : cord-023584-yaxawqhj 119 10 guanidine guanidine NNP cord-023584-yaxawqhj 119 11 and and CC cord-023584-yaxawqhj 119 12 a a DT cord-023584-yaxawqhj 119 13 - - HYPH cord-023584-yaxawqhj 119 14 hydroxybenzyl hydroxybenzyl NN cord-023584-yaxawqhj 119 15 benzimidazole benzimidazole NNS cord-023584-yaxawqhj 119 16 are be VBP cord-023584-yaxawqhj 119 17 active active JJ cord-023584-yaxawqhj 119 18 only only RB cord-023584-yaxawqhj 119 19 against against IN cord-023584-yaxawqhj 119 20 picornaviruses picornavirus NNS cord-023584-yaxawqhj 119 21 and and CC cord-023584-yaxawqhj 119 22 not not RB cord-023584-yaxawqhj 119 23 against against IN cord-023584-yaxawqhj 119 24 other other JJ cord-023584-yaxawqhj 119 25 small small JJ cord-023584-yaxawqhj 119 26 ribonucleic ribonucleic NN cord-023584-yaxawqhj 119 27 acid acid NN cord-023584-yaxawqhj 119 28 ( ( -LRB- cord-023584-yaxawqhj 119 29 RNA RNA NNP cord-023584-yaxawqhj 119 30 ) ) -RRB- cord-023584-yaxawqhj 119 31 viruses virus NNS cord-023584-yaxawqhj 119 32 ( ( -LRB- cord-023584-yaxawqhj 119 33 Eggers Eggers NNP cord-023584-yaxawqhj 119 34 and and CC cord-023584-yaxawqhj 119 35 Tamm Tamm NNP cord-023584-yaxawqhj 119 36 , , , cord-023584-yaxawqhj 119 37 1961 1961 CD cord-023584-yaxawqhj 119 38 ) ) -RRB- cord-023584-yaxawqhj 119 39 . . . cord-023584-yaxawqhj 120 1 Thus thus RB cord-023584-yaxawqhj 120 2 , , , cord-023584-yaxawqhj 120 3 whenever whenever WRB cord-023584-yaxawqhj 120 4 possible possible JJ cord-023584-yaxawqhj 120 5 , , , cord-023584-yaxawqhj 120 6 the the DT cord-023584-yaxawqhj 120 7 viruses virus NNS cord-023584-yaxawqhj 120 8 used use VBN cord-023584-yaxawqhj 120 9 in in IN cord-023584-yaxawqhj 120 10 routine routine JJ cord-023584-yaxawqhj 120 11 screens screen NNS cord-023584-yaxawqhj 120 12 should should MD cord-023584-yaxawqhj 120 13 be be VB cord-023584-yaxawqhj 120 14 those those DT cord-023584-yaxawqhj 120 15 that that WDT cord-023584-yaxawqhj 120 16 are be VBP cord-023584-yaxawqhj 120 17 responsible responsible JJ cord-023584-yaxawqhj 120 18 for for IN cord-023584-yaxawqhj 120 19 the the DT cord-023584-yaxawqhj 120 20 clinical clinical JJ cord-023584-yaxawqhj 120 21 Large large JJ cord-023584-yaxawqhj 120 22 - - HYPH cord-023584-yaxawqhj 120 23 scale scale NN cord-023584-yaxawqhj 120 24 screens screen NNS cord-023584-yaxawqhj 120 25 use use VBP cord-023584-yaxawqhj 120 26 large large JJ cord-023584-yaxawqhj 120 27 numbers number NNS cord-023584-yaxawqhj 120 28 of of IN cord-023584-yaxawqhj 120 29 tissue tissue NN cord-023584-yaxawqhj 120 30 culture culture NN cord-023584-yaxawqhj 120 31 cells cell NNS cord-023584-yaxawqhj 120 32 , , , cord-023584-yaxawqhj 120 33 and and CC cord-023584-yaxawqhj 120 34 there there EX cord-023584-yaxawqhj 120 35 has have VBZ cord-023584-yaxawqhj 120 36 been be VBN cord-023584-yaxawqhj 120 37 an an DT cord-023584-yaxawqhj 120 38 inevitable inevitable JJ cord-023584-yaxawqhj 120 39 trend trend NN cord-023584-yaxawqhj 120 40 toward toward IN cord-023584-yaxawqhj 120 41 the the DT cord-023584-yaxawqhj 120 42 use use NN cord-023584-yaxawqhj 120 43 of of IN cord-023584-yaxawqhj 120 44 continuous continuous JJ cord-023584-yaxawqhj 120 45 cell cell NN cord-023584-yaxawqhj 120 46 lines line NNS cord-023584-yaxawqhj 120 47 in in IN cord-023584-yaxawqhj 120 48 screening screening NN cord-023584-yaxawqhj 120 49 procedures procedure NNS cord-023584-yaxawqhj 120 50 . . . cord-023584-yaxawqhj 121 1 Such such JJ cord-023584-yaxawqhj 121 2 cells cell NNS cord-023584-yaxawqhj 121 3 have have VBP cord-023584-yaxawqhj 121 4 many many JJ cord-023584-yaxawqhj 121 5 attractive attractive JJ cord-023584-yaxawqhj 121 6 features feature NNS cord-023584-yaxawqhj 121 7 . . . cord-023584-yaxawqhj 122 1 They -PRON- PRP cord-023584-yaxawqhj 122 2 grow grow VBP cord-023584-yaxawqhj 122 3 rapidly rapidly RB cord-023584-yaxawqhj 122 4 , , , cord-023584-yaxawqhj 122 5 they -PRON- PRP cord-023584-yaxawqhj 122 6 can can MD cord-023584-yaxawqhj 122 7 easily easily RB cord-023584-yaxawqhj 122 8 be be VB cord-023584-yaxawqhj 122 9 obtained obtain VBN cord-023584-yaxawqhj 122 10 in in IN cord-023584-yaxawqhj 122 11 large large JJ cord-023584-yaxawqhj 122 12 quantities quantity NNS cord-023584-yaxawqhj 122 13 , , , cord-023584-yaxawqhj 122 14 they -PRON- PRP cord-023584-yaxawqhj 122 15 remain remain VBP cord-023584-yaxawqhj 122 16 " " `` cord-023584-yaxawqhj 122 17 the the DT cord-023584-yaxawqhj 122 18 same same JJ cord-023584-yaxawqhj 122 19 " " `` cord-023584-yaxawqhj 122 20 year year NN cord-023584-yaxawqhj 122 21 after after IN cord-023584-yaxawqhj 122 22 year year NN cord-023584-yaxawqhj 122 23 , , , cord-023584-yaxawqhj 122 24 they -PRON- PRP cord-023584-yaxawqhj 122 25 can can MD cord-023584-yaxawqhj 122 26 be be VB cord-023584-yaxawqhj 122 27 madr madr NNP cord-023584-yaxawqhj 122 28 to to TO cord-023584-yaxawqhj 122 29 prrform prrform VB cord-023584-yaxawqhj 122 30 useful useful JJ cord-023584-yaxawqhj 122 31 technical technical JJ cord-023584-yaxawqhj 122 32 tricks trick NNS cord-023584-yaxawqhj 122 33 such such JJ cord-023584-yaxawqhj 122 34 as as IN cord-023584-yaxawqhj 122 35 rapidly rapidly RB cord-023584-yaxawqhj 122 36 changing change VBG cord-023584-yaxawqhj 122 37 the the DT cord-023584-yaxawqhj 122 38 pH ph NN cord-023584-yaxawqhj 122 39 of of IN cord-023584-yaxawqhj 122 40 their -PRON- PRP$ cord-023584-yaxawqhj 122 41 medium medium NN cord-023584-yaxawqhj 122 42 and and CC cord-023584-yaxawqhj 122 43 surviving survive VBG cord-023584-yaxawqhj 122 44 for for IN cord-023584-yaxawqhj 122 45 long long JJ cord-023584-yaxawqhj 122 46 periods period NNS cord-023584-yaxawqhj 122 47 under under IN cord-023584-yaxawqhj 122 48 agar agar NN cord-023584-yaxawqhj 122 49 , , , cord-023584-yaxawqhj 122 50 and and CC cord-023584-yaxawqhj 122 51 , , , cord-023584-yaxawqhj 122 52 perhaps perhaps RB cord-023584-yaxawqhj 122 53 most most RBS cord-023584-yaxawqhj 122 54 important important JJ cord-023584-yaxawqhj 122 55 , , , cord-023584-yaxawqhj 122 56 they -PRON- PRP cord-023584-yaxawqhj 122 57 will will MD cord-023584-yaxawqhj 122 58 support support VB cord-023584-yaxawqhj 122 59 the the DT cord-023584-yaxawqhj 122 60 growth growth NN cord-023584-yaxawqhj 122 61 of of IN cord-023584-yaxawqhj 122 62 a a DT cord-023584-yaxawqhj 122 63 wide wide JJ cord-023584-yaxawqhj 122 64 range range NN cord-023584-yaxawqhj 122 65 of of IN cord-023584-yaxawqhj 122 66 viruses virus NNS cord-023584-yaxawqhj 122 67 . . . cord-023584-yaxawqhj 123 1 Continuous continuous JJ cord-023584-yaxawqhj 123 2 cell cell NN cord-023584-yaxawqhj 123 3 lines line NNS cord-023584-yaxawqhj 123 4 seem seem VBP cord-023584-yaxawqhj 123 5 to to TO cord-023584-yaxawqhj 123 6 be be VB cord-023584-yaxawqhj 123 7 the the DT cord-023584-yaxawqhj 123 8 natural natural JJ cord-023584-yaxawqhj 123 9 choice choice NN cord-023584-yaxawqhj 123 10 for for IN cord-023584-yaxawqhj 123 11 running run VBG cord-023584-yaxawqhj 123 12 routine routine JJ cord-023584-yaxawqhj 123 13 screens screen NNS cord-023584-yaxawqhj 123 14 . . . cord-023584-yaxawqhj 124 1 Xevertheless Xevertheless NNP cord-023584-yaxawqhj 124 2 , , , cord-023584-yaxawqhj 124 3 it -PRON- PRP cord-023584-yaxawqhj 124 4 is be VBZ cord-023584-yaxawqhj 124 5 worthwhile worthwhile JJ cord-023584-yaxawqhj 124 6 remembering remember VBG cord-023584-yaxawqhj 124 7 that that IN cord-023584-yaxawqhj 124 8 many many JJ cord-023584-yaxawqhj 124 9 of of IN cord-023584-yaxawqhj 124 10 the the DT cord-023584-yaxawqhj 124 11 desirable desirable JJ cord-023584-yaxawqhj 124 12 technical technical JJ cord-023584-yaxawqhj 124 13 properties property NNS cord-023584-yaxawqhj 124 14 exhibited exhibit VBN cord-023584-yaxawqhj 124 15 by by IN cord-023584-yaxawqhj 124 16 these these DT cord-023584-yaxawqhj 124 17 cells cell NNS cord-023584-yaxawqhj 124 18 may may MD cord-023584-yaxawqhj 124 19 be be VB cord-023584-yaxawqhj 124 20 a a DT cord-023584-yaxawqhj 124 21 direct direct JJ cord-023584-yaxawqhj 124 22 result result NN cord-023584-yaxawqhj 124 23 of of IN cord-023584-yaxawqhj 124 24 their -PRON- PRP$ cord-023584-yaxawqhj 124 25 neoplastic neoplastic JJ cord-023584-yaxawqhj 124 26 nature nature NN cord-023584-yaxawqhj 124 27 , , , cord-023584-yaxawqhj 124 28 and and CC cord-023584-yaxawqhj 124 29 to to TO cord-023584-yaxawqhj 124 30 use use VB cord-023584-yaxawqhj 124 31 a a DT cord-023584-yaxawqhj 124 32 continuous continuous JJ cord-023584-yaxawqhj 124 33 rather rather RB cord-023584-yaxawqhj 124 34 than than IN cord-023584-yaxawqhj 124 35 a a DT cord-023584-yaxawqhj 124 36 primary primary JJ cord-023584-yaxawqhj 124 37 or or CC cord-023584-yaxawqhj 124 38 diploid diploid JJ cord-023584-yaxawqhj 124 39 cell cell NN cord-023584-yaxawqhj 124 40 in in IN cord-023584-yaxawqhj 124 41 a a DT cord-023584-yaxawqhj 124 42 tissue tissue NN cord-023584-yaxawqhj 124 43 culture culture NN cord-023584-yaxawqhj 124 44 system system NN cord-023584-yaxawqhj 124 45 is be VBZ cord-023584-yaxawqhj 124 46 to to TO cord-023584-yaxawqhj 124 47 take take VB cord-023584-yaxawqhj 124 48 yet yet RB cord-023584-yaxawqhj 124 49 another another DT cord-023584-yaxawqhj 124 50 step step NN cord-023584-yaxawqhj 124 51 away away RB cord-023584-yaxawqhj 124 52 from from IN cord-023584-yaxawqhj 124 53 the the DT cord-023584-yaxawqhj 124 54 natural natural JJ cord-023584-yaxawqhj 124 55 disease disease NN cord-023584-yaxawqhj 124 56 . . . cord-023584-yaxawqhj 125 1 It -PRON- PRP cord-023584-yaxawqhj 125 2 is be VBZ cord-023584-yaxawqhj 125 3 truc truc NN cord-023584-yaxawqhj 125 4 that that IN cord-023584-yaxawqhj 125 5 antiviral antiviral JJ cord-023584-yaxawqhj 125 6 agents agent NNS cord-023584-yaxawqhj 125 7 , , , cord-023584-yaxawqhj 125 8 such such JJ cord-023584-yaxawqhj 125 9 as as IN cord-023584-yaxawqhj 125 10 l l NNP cord-023584-yaxawqhj 125 11 - - HYPH cord-023584-yaxawqhj 125 12 aminoadamantane aminoadamantane NNP cord-023584-yaxawqhj 125 13 and and CC cord-023584-yaxawqhj 125 14 methisazone methisazone NNP cord-023584-yaxawqhj 125 15 , , , cord-023584-yaxawqhj 125 16 which which WDT cord-023584-yaxawqhj 125 17 can can MD cord-023584-yaxawqhj 125 18 be be VB cord-023584-yaxawqhj 125 19 shown show VBN cord-023584-yaxawqhj 125 20 to to TO cord-023584-yaxawqhj 125 21 protect protect VB cord-023584-yaxawqhj 125 22 humans human NNS cord-023584-yaxawqhj 125 23 against against IN cord-023584-yaxawqhj 125 24 virus virus NN cord-023584-yaxawqhj 125 25 diseascs diseascs NNP cord-023584-yaxawqhj 125 26 , , , cord-023584-yaxawqhj 125 27 also also RB cord-023584-yaxawqhj 125 28 exert exert VB cord-023584-yaxawqhj 125 29 their -PRON- PRP$ cord-023584-yaxawqhj 125 30 antiviral antiviral JJ cord-023584-yaxawqhj 125 31 action action NN cord-023584-yaxawqhj 125 32 in in IN cord-023584-yaxawqhj 125 33 neoplastic neoplastic JJ cord-023584-yaxawqhj 125 34 cells cell NNS cord-023584-yaxawqhj 125 35 in in IN cord-023584-yaxawqhj 125 36 tissue tissue NN cord-023584-yaxawqhj 125 37 culture culture NN cord-023584-yaxawqhj 125 38 , , , cord-023584-yaxawqhj 125 39 for for IN cord-023584-yaxawqhj 125 40 example example NN cord-023584-yaxawqhj 125 41 HeLa HeLa NNP cord-023584-yaxawqhj 125 42 and and CC cord-023584-yaxawqhj 125 43 KB KB NNP cord-023584-yaxawqhj 125 44 cells cell NNS cord-023584-yaxawqhj 125 45 , , , cord-023584-yaxawqhj 125 46 but but CC cord-023584-yaxawqhj 125 47 we -PRON- PRP cord-023584-yaxawqhj 125 48 have have VBP cord-023584-yaxawqhj 125 49 striking strike VBG cord-023584-yaxawqhj 125 50 evidence evidence NN cord-023584-yaxawqhj 125 51 that that IN cord-023584-yaxawqhj 125 52 this this DT cord-023584-yaxawqhj 125 53 may may MD cord-023584-yaxawqhj 125 54 not not RB cord-023584-yaxawqhj 125 55 always always RB cord-023584-yaxawqhj 125 56 follow follow VB cord-023584-yaxawqhj 125 57 . . . cord-023584-yaxawqhj 126 1 We -PRON- PRP cord-023584-yaxawqhj 126 2 have have VBP cord-023584-yaxawqhj 126 3 recently recently RB cord-023584-yaxawqhj 126 4 discovered discover VBN cord-023584-yaxawqhj 126 5 a a DT cord-023584-yaxawqhj 126 6 family family NN cord-023584-yaxawqhj 126 7 of of IN cord-023584-yaxawqhj 126 8 chemical chemical JJ cord-023584-yaxawqhj 126 9 compounds compound NNS cord-023584-yaxawqhj 126 10 that that WDT cord-023584-yaxawqhj 126 11 have have VBP cord-023584-yaxawqhj 126 12 high high JJ cord-023584-yaxawqhj 126 13 activity activity NN cord-023584-yaxawqhj 126 14 against against IN cord-023584-yaxawqhj 126 15 rhinoviruses rhinovirus NNS cord-023584-yaxawqhj 126 16 when when WRB cord-023584-yaxawqhj 126 17 grown grow VBN cord-023584-yaxawqhj 126 18 in in IN cord-023584-yaxawqhj 126 19 human human JJ cord-023584-yaxawqhj 126 20 diploid diploid JJ cord-023584-yaxawqhj 126 21 lung lung NN cord-023584-yaxawqhj 126 22 cells cell NNS cord-023584-yaxawqhj 126 23 , , , cord-023584-yaxawqhj 126 24 but but CC cord-023584-yaxawqhj 126 25 virtually virtually RB cord-023584-yaxawqhj 126 26 no no DT cord-023584-yaxawqhj 126 27 activity activity NN cord-023584-yaxawqhj 126 28 against against IN cord-023584-yaxawqhj 126 29 the the DT cord-023584-yaxawqhj 126 30 same same JJ cord-023584-yaxawqhj 126 31 viruscs viruscs NN cord-023584-yaxawqhj 126 32 growing grow VBG cord-023584-yaxawqhj 126 33 in in IN cord-023584-yaxawqhj 126 34 monkey monkey NN cord-023584-yaxawqhj 126 35 kidney kidney NN cord-023584-yaxawqhj 126 36 cells cell NNS cord-023584-yaxawqhj 126 37 , , , cord-023584-yaxawqhj 126 38 HeLa HeLa NNP cord-023584-yaxawqhj 126 39 cells cell NNS cord-023584-yaxawqhj 126 40 , , , cord-023584-yaxawqhj 126 41 or or CC cord-023584-yaxawqhj 126 42 KB KB NNP cord-023584-yaxawqhj 126 43 cells cell NNS cord-023584-yaxawqhj 126 44 ( ( -LRB- cord-023584-yaxawqhj 126 45 Bucknall Bucknall NNP cord-023584-yaxawqhj 126 46 , , , cord-023584-yaxawqhj 126 47 unpublished unpublished JJ cord-023584-yaxawqhj 126 48 results result NNS cord-023584-yaxawqhj 126 49 ) ) -RRB- cord-023584-yaxawqhj 126 50 . . . cord-023584-yaxawqhj 127 1 These these DT cord-023584-yaxawqhj 127 2 compounds compound NNS cord-023584-yaxawqhj 127 3 and and CC cord-023584-yaxawqhj 127 4 any any DT cord-023584-yaxawqhj 127 5 others other NNS cord-023584-yaxawqhj 127 6 that that WDT cord-023584-yaxawqhj 127 7 may may MD cord-023584-yaxawqhj 127 8 exhibit exhibit VB cord-023584-yaxawqhj 127 9 this this DT cord-023584-yaxawqhj 127 10 property property NN cord-023584-yaxawqhj 127 11 would would MD cord-023584-yaxawqhj 127 12 have have VB cord-023584-yaxawqhj 127 13 been be VBN cord-023584-yaxawqhj 127 14 missed miss VBN cord-023584-yaxawqhj 127 15 in in IN cord-023584-yaxawqhj 127 16 tests test NNS cord-023584-yaxawqhj 127 17 carried carry VBN cord-023584-yaxawqhj 127 18 out out RP cord-023584-yaxawqhj 127 19 in in IN cord-023584-yaxawqhj 127 20 continuous continuous JJ cord-023584-yaxawqhj 127 21 cell cell NN cord-023584-yaxawqhj 127 22 lines line NNS cord-023584-yaxawqhj 127 23 . . . cord-023584-yaxawqhj 128 1 In in IN cord-023584-yaxawqhj 128 2 summary summary NN cord-023584-yaxawqhj 128 3 , , , cord-023584-yaxawqhj 128 4 a a DT cord-023584-yaxawqhj 128 5 tissue tissue NN cord-023584-yaxawqhj 128 6 culture culture NN cord-023584-yaxawqhj 128 7 screen screen NN cord-023584-yaxawqhj 128 8 should should MD cord-023584-yaxawqhj 128 9 be be VB cord-023584-yaxawqhj 128 10 able able JJ cord-023584-yaxawqhj 128 11 to to TO cord-023584-yaxawqhj 128 12 proccss proccss VB cord-023584-yaxawqhj 128 13 large large JJ cord-023584-yaxawqhj 128 14 numbers number NNS cord-023584-yaxawqhj 128 15 of of IN cord-023584-yaxawqhj 128 16 tcst tcst NNP cord-023584-yaxawqhj 128 17 compounds compound NNS cord-023584-yaxawqhj 128 18 , , , cord-023584-yaxawqhj 128 19 using use VBG cord-023584-yaxawqhj 128 20 viruses virus NNS cord-023584-yaxawqhj 128 21 as as RB cord-023584-yaxawqhj 128 22 relevant relevant JJ cord-023584-yaxawqhj 128 23 as as IN cord-023584-yaxawqhj 128 24 possible possible JJ cord-023584-yaxawqhj 128 25 to to IN cord-023584-yaxawqhj 128 26 the the DT cord-023584-yaxawqhj 128 27 diseases disease NNS cord-023584-yaxawqhj 128 28 for for IN cord-023584-yaxawqhj 128 29 which which WDT cord-023584-yaxawqhj 128 30 a a DT cord-023584-yaxawqhj 128 31 drug drug NN cord-023584-yaxawqhj 128 32 is be VBZ cord-023584-yaxawqhj 128 33 required require VBN cord-023584-yaxawqhj 128 34 , , , cord-023584-yaxawqhj 128 35 and and CC cord-023584-yaxawqhj 128 36 should should MD cord-023584-yaxawqhj 128 37 employ employ VB cord-023584-yaxawqhj 128 38 normal normal JJ cord-023584-yaxawqhj 128 39 rather rather RB cord-023584-yaxawqhj 128 40 than than IN cord-023584-yaxawqhj 128 41 neoplastic neoplastic JJ cord-023584-yaxawqhj 128 42 cells cell NNS cord-023584-yaxawqhj 128 43 . . . cord-023584-yaxawqhj 129 1 Unfortunately unfortunately RB cord-023584-yaxawqhj 129 2 , , , cord-023584-yaxawqhj 129 3 in in IN cord-023584-yaxawqhj 129 4 most most JJS cord-023584-yaxawqhj 129 5 of of IN cord-023584-yaxawqhj 129 6 the the DT cord-023584-yaxawqhj 129 7 published publish VBN cord-023584-yaxawqhj 129 8 screening screening NN cord-023584-yaxawqhj 129 9 procedures procedure NNS cord-023584-yaxawqhj 129 10 the the DT cord-023584-yaxawqhj 129 11 last last JJ cord-023584-yaxawqhj 129 12 two two CD cord-023584-yaxawqhj 129 13 requirements requirement NNS cord-023584-yaxawqhj 129 14 have have VBP cord-023584-yaxawqhj 129 15 been be VBN cord-023584-yaxawqhj 129 16 sacrificed sacrifice VBN cord-023584-yaxawqhj 129 17 to to IN cord-023584-yaxawqhj 129 18 technical technical JJ cord-023584-yaxawqhj 129 19 considerations consideration NNS cord-023584-yaxawqhj 129 20 designed design VBN cord-023584-yaxawqhj 129 21 to to TO cord-023584-yaxawqhj 129 22 increase increase VB cord-023584-yaxawqhj 129 23 the the DT cord-023584-yaxawqhj 129 24 number number NN cord-023584-yaxawqhj 129 25 of of IN cord-023584-yaxawqhj 129 26 compounds compound NNS cord-023584-yaxawqhj 129 27 tested test VBN cord-023584-yaxawqhj 129 28 , , , cord-023584-yaxawqhj 129 29 as as IN cord-023584-yaxawqhj 129 30 the the DT cord-023584-yaxawqhj 129 31 following follow VBG cord-023584-yaxawqhj 129 32 descriptions description NNS cord-023584-yaxawqhj 129 33 will will MD cord-023584-yaxawqhj 129 34 show show VB cord-023584-yaxawqhj 129 35 . . . cord-023584-yaxawqhj 130 1 In in IN cord-023584-yaxawqhj 130 2 its -PRON- PRP$ cord-023584-yaxawqhj 130 3 simplest simple JJS cord-023584-yaxawqhj 130 4 form form NN cord-023584-yaxawqhj 130 5 , , , cord-023584-yaxawqhj 130 6 a a DT cord-023584-yaxawqhj 130 7 test test NN cord-023584-yaxawqhj 130 8 for for IN cord-023584-yaxawqhj 130 9 antiviral antiviral JJ cord-023584-yaxawqhj 130 10 activity activity NN cord-023584-yaxawqhj 130 11 involves involve VBZ cord-023584-yaxawqhj 130 12 treating treat VBG cord-023584-yaxawqhj 130 13 cultures culture NNS cord-023584-yaxawqhj 130 14 of of IN cord-023584-yaxawqhj 130 15 cells cell NNS cord-023584-yaxawqhj 130 16 with with IN cord-023584-yaxawqhj 130 17 a a DT cord-023584-yaxawqhj 130 18 range range NN cord-023584-yaxawqhj 130 19 of of IN cord-023584-yaxawqhj 130 20 concentrations concentration NNS cord-023584-yaxawqhj 130 21 of of IN cord-023584-yaxawqhj 130 22 a a DT cord-023584-yaxawqhj 130 23 test test NN cord-023584-yaxawqhj 130 24 compound compound NN cord-023584-yaxawqhj 130 25 . . . cord-023584-yaxawqhj 131 1 First first RB cord-023584-yaxawqhj 131 2 the the DT cord-023584-yaxawqhj 131 3 maximum maximum JJ cord-023584-yaxawqhj 131 4 concentration concentration NN cord-023584-yaxawqhj 131 5 tolerated tolerate VBN cord-023584-yaxawqhj 131 6 by by IN cord-023584-yaxawqhj 131 7 the the DT cord-023584-yaxawqhj 131 8 cclls ccll NNS cord-023584-yaxawqhj 131 9 is be VBZ cord-023584-yaxawqhj 131 10 assessed assess VBN cord-023584-yaxawqhj 131 11 ; ; : cord-023584-yaxawqhj 131 12 then then RB cord-023584-yaxawqhj 131 13 , , , cord-023584-yaxawqhj 131 14 second second RB cord-023584-yaxawqhj 131 15 , , , cord-023584-yaxawqhj 131 16 the the DT cord-023584-yaxawqhj 131 17 growth growth NN cord-023584-yaxawqhj 131 18 of of IN cord-023584-yaxawqhj 131 19 virus virus NN cord-023584-yaxawqhj 131 20 at at IN cord-023584-yaxawqhj 131 21 lowcr lowcr NNP cord-023584-yaxawqhj 131 22 concentrations concentration NNS cord-023584-yaxawqhj 131 23 of of IN cord-023584-yaxawqhj 131 24 compound compound NN cord-023584-yaxawqhj 131 25 that that WDT cord-023584-yaxawqhj 131 26 are be VBP cord-023584-yaxawqhj 131 27 not not RB cord-023584-yaxawqhj 131 28 cytotoxic cytotoxic JJ cord-023584-yaxawqhj 131 29 is be VBZ cord-023584-yaxawqhj 131 30 measured measure VBN cord-023584-yaxawqhj 131 31 . . . cord-023584-yaxawqhj 132 1 Several several JJ cord-023584-yaxawqhj 132 2 ingenious ingenious JJ cord-023584-yaxawqhj 132 3 methods method NNS cord-023584-yaxawqhj 132 4 have have VBP cord-023584-yaxawqhj 132 5 been be VBN cord-023584-yaxawqhj 132 6 devised devise VBN cord-023584-yaxawqhj 132 7 for for IN cord-023584-yaxawqhj 132 8 measuring measure VBG cord-023584-yaxawqhj 132 9 these these DT cord-023584-yaxawqhj 132 10 two two CD cord-023584-yaxawqhj 132 11 responses response NNS cord-023584-yaxawqhj 132 12 - - : cord-023584-yaxawqhj 132 13 cytotoxicity cytotoxicity NN cord-023584-yaxawqhj 132 14 and and CC cord-023584-yaxawqhj 132 15 virus virus NN cord-023584-yaxawqhj 132 16 growth growth NN cord-023584-yaxawqhj 132 17 - - , cord-023584-yaxawqhj 132 18 all all DT cord-023584-yaxawqhj 132 19 designed design VBN cord-023584-yaxawqhj 132 20 to to TO cord-023584-yaxawqhj 132 21 facilitate facilitate VB cord-023584-yaxawqhj 132 22 the the DT cord-023584-yaxawqhj 132 23 screening screening NN cord-023584-yaxawqhj 132 24 of of IN cord-023584-yaxawqhj 132 25 large large JJ cord-023584-yaxawqhj 132 26 numbers number NNS cord-023584-yaxawqhj 132 27 of of IN cord-023584-yaxawqhj 132 28 compounds compound NNS cord-023584-yaxawqhj 132 29 . . . cord-023584-yaxawqhj 133 1 For for IN cord-023584-yaxawqhj 133 2 example example NN cord-023584-yaxawqhj 133 3 , , , cord-023584-yaxawqhj 133 4 Herrmann Herrmann NNP cord-023584-yaxawqhj 133 5 et et NNP cord-023584-yaxawqhj 133 6 al al NNP cord-023584-yaxawqhj 133 7 . . . cord-023584-yaxawqhj 134 1 ( ( -LRB- cord-023584-yaxawqhj 134 2 1960 1960 CD cord-023584-yaxawqhj 134 3 ) ) -RRB- cord-023584-yaxawqhj 134 4 devised devise VBD cord-023584-yaxawqhj 134 5 a a DT cord-023584-yaxawqhj 134 6 zone zone NN cord-023584-yaxawqhj 134 7 - - HYPH cord-023584-yaxawqhj 134 8 inhibition inhibition NN cord-023584-yaxawqhj 134 9 test test NN cord-023584-yaxawqhj 134 10 in in IN cord-023584-yaxawqhj 134 11 which which WDT cord-023584-yaxawqhj 134 12 large large JJ cord-023584-yaxawqhj 134 13 flat flat JJ cord-023584-yaxawqhj 134 14 dishes dish NNS cord-023584-yaxawqhj 134 15 of of IN cord-023584-yaxawqhj 134 16 chicken chicken NN cord-023584-yaxawqhj 134 17 cells cell NNS cord-023584-yaxawqhj 134 18 were be VBD cord-023584-yaxawqhj 134 19 infected infect VBN cord-023584-yaxawqhj 134 20 with with IN cord-023584-yaxawqhj 134 21 test test NN cord-023584-yaxawqhj 134 22 virus virus NN cord-023584-yaxawqhj 134 23 , , , cord-023584-yaxawqhj 134 24 overlaid overlay VBN cord-023584-yaxawqhj 134 25 with with IN cord-023584-yaxawqhj 134 26 agar agar NN cord-023584-yaxawqhj 134 27 containing contain VBG cord-023584-yaxawqhj 134 28 a a DT cord-023584-yaxawqhj 134 29 vital vital JJ cord-023584-yaxawqhj 134 30 stain stain NN cord-023584-yaxawqhj 134 31 , , , cord-023584-yaxawqhj 134 32 and and CC cord-023584-yaxawqhj 134 33 paper paper NN cord-023584-yaxawqhj 134 34 discs disc NNS cord-023584-yaxawqhj 134 35 impregnated impregnate VBN cord-023584-yaxawqhj 134 36 with with IN cord-023584-yaxawqhj 134 37 test test NN cord-023584-yaxawqhj 134 38 compounds compound NNS cord-023584-yaxawqhj 134 39 placed place VBN cord-023584-yaxawqhj 134 40 on on IN cord-023584-yaxawqhj 134 41 the the DT cord-023584-yaxawqhj 134 42 surface surface NN cord-023584-yaxawqhj 134 43 of of IN cord-023584-yaxawqhj 134 44 the the DT cord-023584-yaxawqhj 134 45 agar agar NN cord-023584-yaxawqhj 134 46 . . . cord-023584-yaxawqhj 135 1 Compounds compound NNS cord-023584-yaxawqhj 135 2 with with IN cord-023584-yaxawqhj 135 3 antiviral antiviral JJ cord-023584-yaxawqhj 135 4 activity activity NN cord-023584-yaxawqhj 135 5 showed show VBD cord-023584-yaxawqhj 135 6 two two CD cord-023584-yaxawqhj 135 7 concentric concentric JJ cord-023584-yaxawqhj 135 8 zones zone NNS cord-023584-yaxawqhj 135 9 around around IN cord-023584-yaxawqhj 135 10 the the DT cord-023584-yaxawqhj 135 11 paper paper NN cord-023584-yaxawqhj 135 12 disc disc NN cord-023584-yaxawqhj 135 13 , , , cord-023584-yaxawqhj 135 14 the the DT cord-023584-yaxawqhj 135 15 innermost innermost JJS cord-023584-yaxawqhj 135 16 being being NN cord-023584-yaxawqhj 135 17 pale pale JJ cord-023584-yaxawqhj 135 18 in in IN cord-023584-yaxawqhj 135 19 color color NN cord-023584-yaxawqhj 135 20 due due IN cord-023584-yaxawqhj 135 21 to to IN cord-023584-yaxawqhj 135 22 the the DT cord-023584-yaxawqhj 135 23 destruction destruction NN cord-023584-yaxawqhj 135 24 of of IN cord-023584-yaxawqhj 135 25 host host NN cord-023584-yaxawqhj 135 26 cells cell NNS cord-023584-yaxawqhj 135 27 by by IN cord-023584-yaxawqhj 135 28 cytotoxic cytotoxic JJ cord-023584-yaxawqhj 135 29 concentrations concentration NNS cord-023584-yaxawqhj 135 30 of of IN cord-023584-yaxawqhj 135 31 compound compound NN cord-023584-yaxawqhj 135 32 diffusing diffuse VBG cord-023584-yaxawqhj 135 33 from from IN cord-023584-yaxawqhj 135 34 the the DT cord-023584-yaxawqhj 135 35 disc disc NN cord-023584-yaxawqhj 135 36 . . . cord-023584-yaxawqhj 136 1 Outside outside RB cord-023584-yaxawqhj 136 2 this this DT cord-023584-yaxawqhj 136 3 was be VBD cord-023584-yaxawqhj 136 4 a a DT cord-023584-yaxawqhj 136 5 deeply deeply RB cord-023584-yaxawqhj 136 6 staining stain VBG cord-023584-yaxawqhj 136 7 zone zone NN cord-023584-yaxawqhj 136 8 where where WRB cord-023584-yaxawqhj 136 9 cells cell NNS cord-023584-yaxawqhj 136 10 were be VBD cord-023584-yaxawqhj 136 11 exposed expose VBN cord-023584-yaxawqhj 136 12 to to IN cord-023584-yaxawqhj 136 13 nontoxic nontoxic JJ cord-023584-yaxawqhj 136 14 concentrations concentration NNS cord-023584-yaxawqhj 136 15 of of IN cord-023584-yaxawqhj 136 16 compound compound NN cord-023584-yaxawqhj 136 17 which which WDT cord-023584-yaxawqhj 136 18 also also RB cord-023584-yaxawqhj 136 19 protected protect VBD cord-023584-yaxawqhj 136 20 them -PRON- PRP cord-023584-yaxawqhj 136 21 from from IN cord-023584-yaxawqhj 136 22 the the DT cord-023584-yaxawqhj 136 23 destructive destructive JJ cord-023584-yaxawqhj 136 24 effects effect NNS cord-023584-yaxawqhj 136 25 of of IN cord-023584-yaxawqhj 136 26 the the DT cord-023584-yaxawqhj 136 27 virus virus NN cord-023584-yaxawqhj 136 28 with with IN cord-023584-yaxawqhj 136 29 which which WDT cord-023584-yaxawqhj 136 30 they -PRON- PRP cord-023584-yaxawqhj 136 31 had have VBD cord-023584-yaxawqhj 136 32 been be VBN cord-023584-yaxawqhj 136 33 infected infect VBN cord-023584-yaxawqhj 136 34 . . . cord-023584-yaxawqhj 137 1 Beyond beyond IN cord-023584-yaxawqhj 137 2 this this DT cord-023584-yaxawqhj 137 3 , , , cord-023584-yaxawqhj 137 4 where where WRB cord-023584-yaxawqhj 137 5 the the DT cord-023584-yaxawqhj 137 6 concentration concentration NN cord-023584-yaxawqhj 137 7 of of IN cord-023584-yaxawqhj 137 8 compound compound NN cord-023584-yaxawqhj 137 9 was be VBD cord-023584-yaxawqhj 137 10 too too RB cord-023584-yaxawqhj 137 11 low low JJ cord-023584-yaxawqhj 137 12 to to TO cord-023584-yaxawqhj 137 13 protect protect VB cord-023584-yaxawqhj 137 14 the the DT cord-023584-yaxawqhj 137 15 cells cell NNS cord-023584-yaxawqhj 137 16 , , , cord-023584-yaxawqhj 137 17 the the DT cord-023584-yaxawqhj 137 18 cell cell NN cord-023584-yaxawqhj 137 19 sheet sheet NN cord-023584-yaxawqhj 137 20 was be VBD cord-023584-yaxawqhj 137 21 destroyed destroy VBN cord-023584-yaxawqhj 137 22 by by IN cord-023584-yaxawqhj 137 23 virus virus NN cord-023584-yaxawqhj 137 24 and and CC cord-023584-yaxawqhj 137 25 stained stain VBN cord-023584-yaxawqhj 137 26 poorly poorly RB cord-023584-yaxawqhj 137 27 . . . cord-023584-yaxawqhj 138 1 Thus thus RB cord-023584-yaxawqhj 138 2 , , , cord-023584-yaxawqhj 138 3 by by IN cord-023584-yaxawqhj 138 4 visual visual JJ cord-023584-yaxawqhj 138 5 inspection inspection NN cord-023584-yaxawqhj 138 6 of of IN cord-023584-yaxawqhj 138 7 the the DT cord-023584-yaxawqhj 138 8 dishes dish NNS cord-023584-yaxawqhj 138 9 after after IN cord-023584-yaxawqhj 138 10 3 3 CD cord-023584-yaxawqhj 138 11 to to IN cord-023584-yaxawqhj 138 12 4 4 CD cord-023584-yaxawqhj 138 13 days day NNS cord-023584-yaxawqhj 138 14 , , , cord-023584-yaxawqhj 138 15 active active JJ cord-023584-yaxawqhj 138 16 compounds compound NNS cord-023584-yaxawqhj 138 17 could could MD cord-023584-yaxawqhj 138 18 be be VB cord-023584-yaxawqhj 138 19 quickly quickly RB cord-023584-yaxawqhj 138 20 detected detect VBN cord-023584-yaxawqhj 138 21 . . . cord-023584-yaxawqhj 139 1 Rada Rada NNP cord-023584-yaxawqhj 139 2 et et NNP cord-023584-yaxawqhj 139 3 al al NNP cord-023584-yaxawqhj 139 4 . . . cord-023584-yaxawqhj 140 1 ( ( -LRB- cord-023584-yaxawqhj 140 2 1960 1960 CD cord-023584-yaxawqhj 140 3 ) ) -RRB- cord-023584-yaxawqhj 140 4 devised devise VBD cord-023584-yaxawqhj 140 5 a a DT cord-023584-yaxawqhj 140 6 similar similar JJ cord-023584-yaxawqhj 140 7 agar agar NN cord-023584-yaxawqhj 140 8 diffusion diffusion NN cord-023584-yaxawqhj 140 9 test test NN cord-023584-yaxawqhj 140 10 in in IN cord-023584-yaxawqhj 140 11 which which WDT cord-023584-yaxawqhj 140 12 test test NN cord-023584-yaxawqhj 140 13 compounds compound NNS cord-023584-yaxawqhj 140 14 were be VBD cord-023584-yaxawqhj 140 15 applied apply VBN cord-023584-yaxawqhj 140 16 to to IN cord-023584-yaxawqhj 140 17 the the DT cord-023584-yaxawqhj 140 18 virus virus NN cord-023584-yaxawqhj 140 19 - - HYPH cord-023584-yaxawqhj 140 20 infected infect VBN cord-023584-yaxawqhj 140 21 cell cell NN cord-023584-yaxawqhj 140 22 sheets sheet NNS cord-023584-yaxawqhj 140 23 in in IN cord-023584-yaxawqhj 140 24 circular circular JJ cord-023584-yaxawqhj 140 25 wells well NNS cord-023584-yaxawqhj 140 26 in in IN cord-023584-yaxawqhj 140 27 the the DT cord-023584-yaxawqhj 140 28 agar agar NNP cord-023584-yaxawqhj 140 29 overlay overlay NN cord-023584-yaxawqhj 140 30 . . . cord-023584-yaxawqhj 141 1 Although although IN cord-023584-yaxawqhj 141 2 agar agar JJ cord-023584-yaxawqhj 141 3 diffusion diffusion NN cord-023584-yaxawqhj 141 4 tests test NNS cord-023584-yaxawqhj 141 5 are be VBP cord-023584-yaxawqhj 141 6 capable capable JJ cord-023584-yaxawqhj 141 7 of of IN cord-023584-yaxawqhj 141 8 processing process VBG cord-023584-yaxawqhj 141 9 large large JJ cord-023584-yaxawqhj 141 10 numbers number NNS cord-023584-yaxawqhj 141 11 of of IN cord-023584-yaxawqhj 141 12 test test NN cord-023584-yaxawqhj 141 13 compounds compound NNS cord-023584-yaxawqhj 141 14 , , , cord-023584-yaxawqhj 141 15 they -PRON- PRP cord-023584-yaxawqhj 141 16 suffer suffer VBP cord-023584-yaxawqhj 141 17 from from IN cord-023584-yaxawqhj 141 18 two two CD cord-023584-yaxawqhj 141 19 drawbacks drawback NNS cord-023584-yaxawqhj 141 20 . . . cord-023584-yaxawqhj 142 1 First first RB cord-023584-yaxawqhj 142 2 , , , cord-023584-yaxawqhj 142 3 they -PRON- PRP cord-023584-yaxawqhj 142 4 are be VBP cord-023584-yaxawqhj 142 5 of of IN cord-023584-yaxawqhj 142 6 comparatively comparatively RB cord-023584-yaxawqhj 142 7 low low JJ cord-023584-yaxawqhj 142 8 .sensitivity .sensitivity NN cord-023584-yaxawqhj 142 9 in in IN cord-023584-yaxawqhj 142 10 detecting detect VBG cord-023584-yaxawqhj 142 11 both both CC cord-023584-yaxawqhj 142 12 the the DT cord-023584-yaxawqhj 142 13 cytotoxic cytotoxic JJ cord-023584-yaxawqhj 142 14 and and CC cord-023584-yaxawqhj 142 15 antiviral antiviral JJ cord-023584-yaxawqhj 142 16 levels level NNS cord-023584-yaxawqhj 142 17 of of IN cord-023584-yaxawqhj 142 18 compounds compound NNS cord-023584-yaxawqhj 142 19 , , , cord-023584-yaxawqhj 142 20 and and CC cord-023584-yaxawqhj 142 21 second second RB cord-023584-yaxawqhj 142 22 , , , cord-023584-yaxawqhj 142 23 they -PRON- PRP cord-023584-yaxawqhj 142 24 are be VBP cord-023584-yaxawqhj 142 25 limited limit VBN cord-023584-yaxawqhj 142 26 to to IN cord-023584-yaxawqhj 142 27 viruses virus NNS cord-023584-yaxawqhj 142 28 that that WDT cord-023584-yaxawqhj 142 29 produce produce VBP cord-023584-yaxawqhj 142 30 plaques plaque NNS cord-023584-yaxawqhj 142 31 under under IN cord-023584-yaxawqhj 142 32 agar agar NN cord-023584-yaxawqhj 142 33 . . . cord-023584-yaxawqhj 143 1 Rightsel Rightsel NNP cord-023584-yaxawqhj 143 2 et et NNP cord-023584-yaxawqhj 143 3 al al NNP cord-023584-yaxawqhj 143 4 . . . cord-023584-yaxawqhj 144 1 ( ( -LRB- cord-023584-yaxawqhj 144 2 1956 1956 CD cord-023584-yaxawqhj 144 3 ) ) -RRB- cord-023584-yaxawqhj 144 4 devised devise VBD cord-023584-yaxawqhj 144 5 a a DT cord-023584-yaxawqhj 144 6 system system NN cord-023584-yaxawqhj 144 7 based base VBN cord-023584-yaxawqhj 144 8 on on IN cord-023584-yaxawqhj 144 9 the the DT cord-023584-yaxawqhj 144 10 fact fact NN cord-023584-yaxawqhj 144 11 that that IN cord-023584-yaxawqhj 144 12 if if IN cord-023584-yaxawqhj 144 13 cells cell NNS cord-023584-yaxawqhj 144 14 were be VBD cord-023584-yaxawqhj 144 15 damaged damage VBN cord-023584-yaxawqhj 144 16 either either CC cord-023584-yaxawqhj 144 17 by by IN cord-023584-yaxawqhj 144 18 the the DT cord-023584-yaxawqhj 144 19 toxic toxic JJ cord-023584-yaxawqhj 144 20 effects effect NNS cord-023584-yaxawqhj 144 21 of of IN cord-023584-yaxawqhj 144 22 a a DT cord-023584-yaxawqhj 144 23 chemical chemical NN cord-023584-yaxawqhj 144 24 compound compound NN cord-023584-yaxawqhj 144 25 or or CC cord-023584-yaxawqhj 144 26 by by IN cord-023584-yaxawqhj 144 27 virus virus NN cord-023584-yaxawqhj 144 28 growth growth NN cord-023584-yaxawqhj 144 29 , , , cord-023584-yaxawqhj 144 30 they -PRON- PRP cord-023584-yaxawqhj 144 31 would would MD cord-023584-yaxawqhj 144 32 not not RB cord-023584-yaxawqhj 144 33 swing swing VB cord-023584-yaxawqhj 144 34 the the DT cord-023584-yaxawqhj 144 35 pH ph NN cord-023584-yaxawqhj 144 36 of of IN cord-023584-yaxawqhj 144 37 their -PRON- PRP$ cord-023584-yaxawqhj 144 38 medium medium NN cord-023584-yaxawqhj 144 39 . . . cord-023584-yaxawqhj 145 1 Thus thus RB cord-023584-yaxawqhj 145 2 , , , cord-023584-yaxawqhj 145 3 by by IN cord-023584-yaxawqhj 145 4 incubating incubate VBG cord-023584-yaxawqhj 145 5 virus virus NN cord-023584-yaxawqhj 145 6 - - HYPH cord-023584-yaxawqhj 145 7 infected infect VBN cord-023584-yaxawqhj 145 8 cells cell NNS cord-023584-yaxawqhj 145 9 in in IN cord-023584-yaxawqhj 145 10 a a DT cord-023584-yaxawqhj 145 11 series series NN cord-023584-yaxawqhj 145 12 of of IN cord-023584-yaxawqhj 145 13 concentrations concentration NNS cord-023584-yaxawqhj 145 14 of of IN cord-023584-yaxawqhj 145 15 a a DT cord-023584-yaxawqhj 145 16 compound compound NN cord-023584-yaxawqhj 145 17 and and CC cord-023584-yaxawqhj 145 18 then then RB cord-023584-yaxawqhj 145 19 looking look VBG cord-023584-yaxawqhj 145 20 for for IN cord-023584-yaxawqhj 145 21 the the DT cord-023584-yaxawqhj 145 22 cultures culture NNS cord-023584-yaxawqhj 145 23 that that WDT cord-023584-yaxawqhj 145 24 had have VBD cord-023584-yaxawqhj 145 25 changed change VBN cord-023584-yaxawqhj 145 26 the the DT cord-023584-yaxawqhj 145 27 color color NN cord-023584-yaxawqhj 145 28 of of IN cord-023584-yaxawqhj 145 29 the the DT cord-023584-yaxawqhj 145 30 phenol phenol NN cord-023584-yaxawqhj 145 31 red red JJ cord-023584-yaxawqhj 145 32 indicator indicator NN cord-023584-yaxawqhj 145 33 in in IN cord-023584-yaxawqhj 145 34 their -PRON- PRP$ cord-023584-yaxawqhj 145 35 medium medium NN cord-023584-yaxawqhj 145 36 from from IN cord-023584-yaxawqhj 145 37 pink pink JJ cord-023584-yaxawqhj 145 38 to to IN cord-023584-yaxawqhj 145 39 yellow yellow JJ cord-023584-yaxawqhj 145 40 , , , cord-023584-yaxawqhj 145 41 active active JJ cord-023584-yaxawqhj 145 42 compounds compound NNS cord-023584-yaxawqhj 145 43 could could MD cord-023584-yaxawqhj 145 44 be be VB cord-023584-yaxawqhj 145 45 detected detect VBN cord-023584-yaxawqhj 145 46 . . . cord-023584-yaxawqhj 146 1 This this DT cord-023584-yaxawqhj 146 2 technique technique NN cord-023584-yaxawqhj 146 3 has have VBZ cord-023584-yaxawqhj 146 4 also also RB cord-023584-yaxawqhj 146 5 been be VBN cord-023584-yaxawqhj 146 6 used use VBN cord-023584-yaxawqhj 146 7 to to TO cord-023584-yaxawqhj 146 8 assay assay VB cord-023584-yaxawqhj 146 9 neutralizing neutralize VBG cord-023584-yaxawqhj 146 10 antibody antibody NN cord-023584-yaxawqhj 146 11 and and CC cord-023584-yaxawqhj 146 12 interferon interferon NN cord-023584-yaxawqhj 146 13 action action NN cord-023584-yaxawqhj 146 14 ( ( -LRB- cord-023584-yaxawqhj 146 15 Pauker Pauker NNP cord-023584-yaxawqhj 146 16 , , , cord-023584-yaxawqhj 146 17 1965 1965 CD cord-023584-yaxawqhj 146 18 ) ) -RRB- cord-023584-yaxawqhj 146 19 . . . cord-023584-yaxawqhj 147 1 Finter Finter NNP cord-023584-yaxawqhj 147 2 ( ( -LRB- cord-023584-yaxawqhj 147 3 1970 1970 CD cord-023584-yaxawqhj 147 4 ) ) -RRB- cord-023584-yaxawqhj 147 5 described describe VBD cord-023584-yaxawqhj 147 6 a a DT cord-023584-yaxawqhj 147 7 system system NN cord-023584-yaxawqhj 147 8 whereby whereby WRB cord-023584-yaxawqhj 147 9 the the DT cord-023584-yaxawqhj 147 10 cytotoxic cytotoxic JJ cord-023584-yaxawqhj 147 11 effects effect NNS cord-023584-yaxawqhj 147 12 of of IN cord-023584-yaxawqhj 147 13 test test NN cord-023584-yaxawqhj 147 14 compounds compound NNS cord-023584-yaxawqhj 147 15 could could MD cord-023584-yaxawqhj 147 16 be be VB cord-023584-yaxawqhj 147 17 assayed assay VBN cord-023584-yaxawqhj 147 18 by by IN cord-023584-yaxawqhj 147 19 the the DT cord-023584-yaxawqhj 147 20 reduction reduction NN cord-023584-yaxawqhj 147 21 in in IN cord-023584-yaxawqhj 147 22 the the DT cord-023584-yaxawqhj 147 23 amount amount NN cord-023584-yaxawqhj 147 24 of of IN cord-023584-yaxawqhj 147 25 neutral neutral JJ cord-023584-yaxawqhj 147 26 red red NN cord-023584-yaxawqhj 147 27 taken take VBN cord-023584-yaxawqhj 147 28 up up RP cord-023584-yaxawqhj 147 29 by by IN cord-023584-yaxawqhj 147 30 treated treat VBN cord-023584-yaxawqhj 147 31 cells cell NNS cord-023584-yaxawqhj 147 32 , , , cord-023584-yaxawqhj 147 33 and and CC cord-023584-yaxawqhj 147 34 , , , cord-023584-yaxawqhj 147 35 similarly similarly RB cord-023584-yaxawqhj 147 36 , , , cord-023584-yaxawqhj 147 37 the the DT cord-023584-yaxawqhj 147 38 cytopathic cytopathic JJ cord-023584-yaxawqhj 147 39 effects effect NNS cord-023584-yaxawqhj 147 40 of of IN cord-023584-yaxawqhj 147 41 virus virus NN cord-023584-yaxawqhj 147 42 growth growth NN cord-023584-yaxawqhj 147 43 could could MD cord-023584-yaxawqhj 147 44 be be VB cord-023584-yaxawqhj 147 45 quantitated quantitate VBN cord-023584-yaxawqhj 147 46 by by IN cord-023584-yaxawqhj 147 47 measuring measure VBG cord-023584-yaxawqhj 147 48 the the DT cord-023584-yaxawqhj 147 49 reduction reduction NN cord-023584-yaxawqhj 147 50 in in IN cord-023584-yaxawqhj 147 51 the the DT cord-023584-yaxawqhj 147 52 uptake uptake NN cord-023584-yaxawqhj 147 53 of of IN cord-023584-yaxawqhj 147 54 neutral neutral JJ cord-023584-yaxawqhj 147 55 red red NN cord-023584-yaxawqhj 147 56 by by IN cord-023584-yaxawqhj 147 57 infected infected JJ cord-023584-yaxawqhj 147 58 cells cell NNS cord-023584-yaxawqhj 147 59 . . . cord-023584-yaxawqhj 148 1 The the DT cord-023584-yaxawqhj 148 2 system system NN cord-023584-yaxawqhj 148 3 can can MD cord-023584-yaxawqhj 148 4 readily readily RB cord-023584-yaxawqhj 148 5 be be VB cord-023584-yaxawqhj 148 6 adapted adapt VBN cord-023584-yaxawqhj 148 7 to to IN cord-023584-yaxawqhj 148 8 the the DT cord-023584-yaxawqhj 148 9 screening screening NN cord-023584-yaxawqhj 148 10 of of IN cord-023584-yaxawqhj 148 11 test test NN cord-023584-yaxawqhj 148 12 compounds compound NNS cord-023584-yaxawqhj 148 13 for for IN cord-023584-yaxawqhj 148 14 antiviral antiviral JJ cord-023584-yaxawqhj 148 15 activity activity NN cord-023584-yaxawqhj 148 16 . . . cord-023584-yaxawqhj 149 1 If if IN cord-023584-yaxawqhj 149 2 myxoviruses myxovirus NNS cord-023584-yaxawqhj 149 3 are be VBP cord-023584-yaxawqhj 149 4 used use VBN cord-023584-yaxawqhj 149 5 in in IN cord-023584-yaxawqhj 149 6 this this DT cord-023584-yaxawqhj 149 7 system system NN cord-023584-yaxawqhj 149 8 , , , cord-023584-yaxawqhj 149 9 because because IN cord-023584-yaxawqhj 149 10 their -PRON- PRP$ cord-023584-yaxawqhj 149 11 cytopathic cytopathic JJ cord-023584-yaxawqhj 149 12 effects effect NNS cord-023584-yaxawqhj 149 13 may may MD cord-023584-yaxawqhj 149 14 not not RB cord-023584-yaxawqhj 149 15 be be VB cord-023584-yaxawqhj 149 16 pronounced pronounce VBN cord-023584-yaxawqhj 149 17 , , , cord-023584-yaxawqhj 149 18 their -PRON- PRP$ cord-023584-yaxawqhj 149 19 growth growth NN cord-023584-yaxawqhj 149 20 is be VBZ cord-023584-yaxawqhj 149 21 best well RBS cord-023584-yaxawqhj 149 22 monitored monitor VBN cord-023584-yaxawqhj 149 23 , , , cord-023584-yaxawqhj 149 24 not not RB cord-023584-yaxawqhj 149 25 by by IN cord-023584-yaxawqhj 149 26 a a DT cord-023584-yaxawqhj 149 27 reduction reduction NN cord-023584-yaxawqhj 149 28 in in IN cord-023584-yaxawqhj 149 29 neutral neutral JJ cord-023584-yaxawqhj 149 30 red red JJ cord-023584-yaxawqhj 149 31 uptake uptake NN cord-023584-yaxawqhj 149 32 , , , cord-023584-yaxawqhj 149 33 but but CC cord-023584-yaxawqhj 149 34 by by IN cord-023584-yaxawqhj 149 35 a a DT cord-023584-yaxawqhj 149 36 quantitative quantitative JJ cord-023584-yaxawqhj 149 37 hemadsorption hemadsorption NN cord-023584-yaxawqhj 149 38 method method NN cord-023584-yaxawqhj 149 39 which which WDT cord-023584-yaxawqhj 149 40 matches match VBZ cord-023584-yaxawqhj 149 41 the the DT cord-023584-yaxawqhj 149 42 neutral neutral JJ cord-023584-yaxawqhj 149 43 red red JJ cord-023584-yaxawqhj 149 44 uptake uptake NN cord-023584-yaxawqhj 149 45 method method NN cord-023584-yaxawqhj 149 46 in in IN cord-023584-yaxawqhj 149 47 its -PRON- PRP$ cord-023584-yaxawqhj 149 48 accuracy accuracy NN cord-023584-yaxawqhj 149 49 and and CC cord-023584-yaxawqhj 149 50 sensitivity sensitivity NN cord-023584-yaxawqhj 149 51 ( ( -LRB- cord-023584-yaxawqhj 149 52 Finter Finter NNP cord-023584-yaxawqhj 149 53 , , , cord-023584-yaxawqhj 149 54 1964 1964 CD cord-023584-yaxawqhj 149 55 ) ) -RRB- cord-023584-yaxawqhj 149 56 . . . cord-023584-yaxawqhj 150 1 In in IN cord-023584-yaxawqhj 150 2 contrast contrast NN cord-023584-yaxawqhj 150 3 to to IN cord-023584-yaxawqhj 150 4 the the DT cord-023584-yaxawqhj 150 5 eone eone NN cord-023584-yaxawqhj 150 6 - - HYPH cord-023584-yaxawqhj 150 7 inhibition inhibition NN cord-023584-yaxawqhj 150 8 and and CC cord-023584-yaxawqhj 150 9 pH ph NN cord-023584-yaxawqhj 150 10 - - HYPH cord-023584-yaxawqhj 150 11 swing swing NN cord-023584-yaxawqhj 150 12 tests test NNS cord-023584-yaxawqhj 150 13 , , , cord-023584-yaxawqhj 150 14 the the DT cord-023584-yaxawqhj 150 15 neutral neutral JJ cord-023584-yaxawqhj 150 16 red red JJ cord-023584-yaxawqhj 150 17 uptake uptake NN cord-023584-yaxawqhj 150 18 test test NN cord-023584-yaxawqhj 150 19 is be VBZ cord-023584-yaxawqhj 150 20 precise precise JJ cord-023584-yaxawqhj 150 21 in in IN cord-023584-yaxawqhj 150 22 operation operation NN cord-023584-yaxawqhj 150 23 and and CC cord-023584-yaxawqhj 150 24 may may MD cord-023584-yaxawqhj 150 25 be be VB cord-023584-yaxawqhj 150 26 used use VBN cord-023584-yaxawqhj 150 27 to to TO cord-023584-yaxawqhj 150 28 demonstrate demonstrate VB cord-023584-yaxawqhj 150 29 fine fine JJ cord-023584-yaxawqhj 150 30 differences difference NNS cord-023584-yaxawqhj 150 31 in in IN cord-023584-yaxawqhj 150 32 the the DT cord-023584-yaxawqhj 150 33 relative relative JJ cord-023584-yaxawqhj 150 34 toxicity toxicity NN cord-023584-yaxawqhj 150 35 and and CC cord-023584-yaxawqhj 150 36 activity activity NN cord-023584-yaxawqhj 150 37 of of IN cord-023584-yaxawqhj 150 38 test test NN cord-023584-yaxawqhj 150 39 compounds compound NNS cord-023584-yaxawqhj 150 40 ; ; : cord-023584-yaxawqhj 150 41 it -PRON- PRP cord-023584-yaxawqhj 150 42 is be VBZ cord-023584-yaxawqhj 150 43 probably probably RB cord-023584-yaxawqhj 150 44 no no RB cord-023584-yaxawqhj 150 45 more more RBR cord-023584-yaxawqhj 150 46 timeconsuming timeconsuming JJ cord-023584-yaxawqhj 150 47 than than IN cord-023584-yaxawqhj 150 48 the the DT cord-023584-yaxawqhj 150 49 former former JJ cord-023584-yaxawqhj 150 50 tests test NNS cord-023584-yaxawqhj 150 51 . . . cord-023584-yaxawqhj 151 1 A a DT cord-023584-yaxawqhj 151 2 system system NN cord-023584-yaxawqhj 151 3 of of IN cord-023584-yaxawqhj 151 4 testing testing NN cord-023584-yaxawqhj 151 5 for for IN cord-023584-yaxawqhj 151 6 antiviral antiviral JJ cord-023584-yaxawqhj 151 7 agents agent NNS cord-023584-yaxawqhj 151 8 based base VBN cord-023584-yaxawqhj 151 9 on on IN cord-023584-yaxawqhj 151 10 the the DT cord-023584-yaxawqhj 151 11 inhibition inhibition NN cord-023584-yaxawqhj 151 12 of of IN cord-023584-yaxawqhj 151 13 nucleic nucleic JJ cord-023584-yaxawqhj 151 14 acid acid NN cord-023584-yaxawqhj 151 15 synthesis synthesis NN cord-023584-yaxawqhj 151 16 was be VBD cord-023584-yaxawqhj 151 17 dcscribcd dcscribcd NNP cord-023584-yaxawqhj 151 18 by by IN cord-023584-yaxawqhj 151 19 lliller lliller NNP cord-023584-yaxawqhj 151 20 et et NNP cord-023584-yaxawqhj 151 21 al al NNP cord-023584-yaxawqhj 151 22 . . . cord-023584-yaxawqhj 152 1 ( ( -LRB- cord-023584-yaxawqhj 152 2 1970 1970 CD cord-023584-yaxawqhj 152 3 ) ) -RRB- cord-023584-yaxawqhj 153 1 and and CC cord-023584-yaxawqhj 153 2 has have VBZ cord-023584-yaxawqhj 153 3 been be VBN cord-023584-yaxawqhj 153 4 used use VBN cord-023584-yaxawqhj 153 5 to to TO cord-023584-yaxawqhj 153 6 screen screen VB cord-023584-yaxawqhj 153 7 Compounds compound NNS cord-023584-yaxawqhj 153 8 and and CC cord-023584-yaxawqhj 153 9 mold mold NN cord-023584-yaxawqhj 153 10 metabolites metabolite NNS cord-023584-yaxawqhj 153 11 for for IN cord-023584-yaxawqhj 153 12 antiviral antiviral JJ cord-023584-yaxawqhj 153 13 activity activity NN cord-023584-yaxawqhj 154 1 ( ( -LRB- cord-023584-yaxawqhj 154 2 Miller Miller NNP cord-023584-yaxawqhj 154 3 et et NNP cord-023584-yaxawqhj 154 4 ul ul NN cord-023584-yaxawqhj 154 5 . . NNP cord-023584-yaxawqhj 154 6 , , , cord-023584-yaxawqhj 154 7 _SP cord-023584-yaxawqhj 154 8 1968 1968 CD cord-023584-yaxawqhj 154 9 ) ) -RRB- cord-023584-yaxawqhj 154 10 . . . cord-023584-yaxawqhj 155 1 For for IN cord-023584-yaxawqhj 155 2 the the DT cord-023584-yaxawqhj 155 3 test test NN cord-023584-yaxawqhj 155 4 , , , cord-023584-yaxawqhj 155 5 HeLa HeLa NNP cord-023584-yaxawqhj 155 6 cells cell NNS cord-023584-yaxawqhj 155 7 were be VBD cord-023584-yaxawqhj 155 8 suspended suspend VBN cord-023584-yaxawqhj 155 9 in in IN cord-023584-yaxawqhj 155 10 a a DT cord-023584-yaxawqhj 155 11 medium medium NN cord-023584-yaxawqhj 155 12 containing contain VBG cord-023584-yaxawqhj 155 13 uridine-3H. uridine-3H. NNP cord-023584-yaxawqhj 156 1 If if IN cord-023584-yaxawqhj 156 2 a a DT cord-023584-yaxawqhj 156 3 test test NN cord-023584-yaxawqhj 156 4 compound compound NN cord-023584-yaxawqhj 156 5 has have VBZ cord-023584-yaxawqhj 156 6 toxic toxic JJ cord-023584-yaxawqhj 156 7 effects effect NNS cord-023584-yaxawqhj 156 8 on on IN cord-023584-yaxawqhj 156 9 the the DT cord-023584-yaxawqhj 156 10 HeLa HeLa NNP cord-023584-yaxawqhj 156 11 cells cell NNS cord-023584-yaxawqhj 156 12 , , , cord-023584-yaxawqhj 156 13 then then RB cord-023584-yaxawqhj 156 14 the the DT cord-023584-yaxawqhj 156 15 cellular cellular JJ cord-023584-yaxawqhj 156 16 R r NN cord-023584-yaxawqhj 156 17 S S NNP cord-023584-yaxawqhj 156 18 A A NNP cord-023584-yaxawqhj 156 19 synthesis synthesis NN cord-023584-yaxawqhj 156 20 , , , cord-023584-yaxawqhj 156 21 as as IN cord-023584-yaxawqhj 156 22 measured measure VBN cord-023584-yaxawqhj 156 23 by by IN cord-023584-yaxawqhj 156 24 u u NNP cord-023584-yaxawqhj 156 25 r r NNP cord-023584-yaxawqhj 156 26 i i NN cord-023584-yaxawqhj 156 27 d d NN cord-023584-yaxawqhj 156 28 i i NNP cord-023584-yaxawqhj 156 29 n~-~H n~-~H NNP cord-023584-yaxawqhj 156 30 fixation fixation NN cord-023584-yaxawqhj 156 31 , , , cord-023584-yaxawqhj 156 32 will will MD cord-023584-yaxawqhj 156 33 be be VB cord-023584-yaxawqhj 156 34 reduced reduce VBN cord-023584-yaxawqhj 156 35 . . . cord-023584-yaxawqhj 157 1 Similarly similarly RB cord-023584-yaxawqhj 157 2 , , , cord-023584-yaxawqhj 157 3 if if IN cord-023584-yaxawqhj 157 4 cells cell NNS cord-023584-yaxawqhj 157 5 are be VBP cord-023584-yaxawqhj 157 6 infected infect VBN cord-023584-yaxawqhj 157 7 with with IN cord-023584-yaxawqhj 157 8 an an DT cord-023584-yaxawqhj 157 9 R r NN cord-023584-yaxawqhj 157 10 S S NNP cord-023584-yaxawqhj 157 11 A A NNP cord-023584-yaxawqhj 157 12 virus virus NN cord-023584-yaxawqhj 157 13 and and CC cord-023584-yaxawqhj 157 14 treated treat VBN cord-023584-yaxawqhj 157 15 with with IN cord-023584-yaxawqhj 157 16 sctinomycin sctinomycin NNP cord-023584-yaxawqhj 157 17 D. D. NNP cord-023584-yaxawqhj 157 18 then then RB cord-023584-yaxawqhj 158 1 R R NNP cord-023584-yaxawqhj 158 2 S S NNP cord-023584-yaxawqhj 158 3 A a DT cord-023584-yaxawqhj 158 4 synthesis synthesis NN cord-023584-yaxawqhj 158 5 will will MD cord-023584-yaxawqhj 158 6 be be VB cord-023584-yaxawqhj 158 7 due due JJ cord-023584-yaxawqhj 158 8 to to IN cord-023584-yaxawqhj 158 9 virus virus NN cord-023584-yaxawqhj 158 10 growth growth NN cord-023584-yaxawqhj 158 11 only only RB cord-023584-yaxawqhj 158 12 . . . cord-023584-yaxawqhj 159 1 Thus thus RB cord-023584-yaxawqhj 159 2 , , , cord-023584-yaxawqhj 159 3 if if IN cord-023584-yaxawqhj 159 4 test test NN cord-023584-yaxawqhj 159 5 compounds compound NNS cord-023584-yaxawqhj 159 6 reduce reduce VBP cord-023584-yaxawqhj 159 7 this this DT cord-023584-yaxawqhj 159 8 virus virus NN cord-023584-yaxawqhj 159 9 - - HYPH cord-023584-yaxawqhj 159 10 directed direct VBN cord-023584-yaxawqhj 159 11 RXA RXA NNP cord-023584-yaxawqhj 159 12 synthesis synthesis NN cord-023584-yaxawqhj 159 13 at at IN cord-023584-yaxawqhj 159 14 concentrations concentration NNS cord-023584-yaxawqhj 159 15 that that WDT cord-023584-yaxawqhj 159 16 do do VBP cord-023584-yaxawqhj 159 17 not not RB cord-023584-yaxawqhj 159 18 affect affect VB cord-023584-yaxawqhj 159 19 cellular cellular JJ cord-023584-yaxawqhj 159 20 R r NN cord-023584-yaxawqhj 159 21 S s NN cord-023584-yaxawqhj 159 22 A A NNP cord-023584-yaxawqhj 159 23 synthesis synthesis NN cord-023584-yaxawqhj 159 24 , , , cord-023584-yaxawqhj 159 25 then then RB cord-023584-yaxawqhj 159 26 the the DT cord-023584-yaxawqhj 159 27 compound compound NN cord-023584-yaxawqhj 159 28 is be VBZ cord-023584-yaxawqhj 159 29 exerting exert VBG cord-023584-yaxawqhj 159 30 a a DT cord-023584-yaxawqhj 159 31 specific specific JJ cord-023584-yaxawqhj 159 32 effect effect NN cord-023584-yaxawqhj 159 33 on on IN cord-023584-yaxawqhj 159 34 virus virus NN cord-023584-yaxawqhj 159 35 growth growth NN cord-023584-yaxawqhj 159 36 . . . cord-023584-yaxawqhj 160 1 The the DT cord-023584-yaxawqhj 160 2 test test NN cord-023584-yaxawqhj 160 3 can can MD cord-023584-yaxawqhj 160 4 also also RB cord-023584-yaxawqhj 160 5 be be VB cord-023584-yaxawqhj 160 6 used use VBN cord-023584-yaxawqhj 160 7 for for IN cord-023584-yaxawqhj 160 8 deoxyribonucleic deoxyribonucleic NN cord-023584-yaxawqhj 160 9 acid acid NN cord-023584-yaxawqhj 160 10 ( ( -LRB- cord-023584-yaxawqhj 160 11 DSA DSA NNP cord-023584-yaxawqhj 160 12 ) ) -RRB- cord-023584-yaxawqhj 160 13 viruses virus NNS cord-023584-yaxawqhj 160 14 , , , cord-023584-yaxawqhj 160 15 the the DT cord-023584-yaxawqhj 160 16 cellular cellular JJ cord-023584-yaxawqhj 160 17 and and CC cord-023584-yaxawqhj 160 18 virus virus NN cord-023584-yaxawqhj 160 19 DXA DXA NNP cord-023584-yaxawqhj 160 20 synthesis synthesis NN cord-023584-yaxawqhj 160 21 being be VBG cord-023584-yaxawqhj 160 22 monitored monitor VBN cord-023584-yaxawqhj 160 23 by by IN cord-023584-yaxawqhj 160 24 including include VBG cord-023584-yaxawqhj 160 25 th th XX cord-023584-yaxawqhj 160 26 ~ ~ CD cord-023584-yaxawqhj 160 27 midine-~H midine-~h NN cord-023584-yaxawqhj 161 1 in in IN cord-023584-yaxawqhj 161 2 the the DT cord-023584-yaxawqhj 161 3 medium medium NN cord-023584-yaxawqhj 161 4 . . . cord-023584-yaxawqhj 162 1 Virus virus NN cord-023584-yaxawqhj 162 2 DSA DSA NNP cord-023584-yaxawqhj 162 3 synthesis synthesis NN cord-023584-yaxawqhj 162 4 is be VBZ cord-023584-yaxawqhj 162 5 distinguished distinguish VBN cord-023584-yaxawqhj 162 6 from from IN cord-023584-yaxawqhj 162 7 cellular cellular JJ cord-023584-yaxawqhj 162 8 DSA DSA NNP cord-023584-yaxawqhj 162 9 synthesis synthesis NN cord-023584-yaxawqhj 162 10 by by IN cord-023584-yaxawqhj 162 11 disrupting disrupt VBG cord-023584-yaxawqhj 162 12 the the DT cord-023584-yaxawqhj 162 13 cells cell NNS cord-023584-yaxawqhj 162 14 at at IN cord-023584-yaxawqhj 162 15 the the DT cord-023584-yaxawqhj 162 16 end end NN cord-023584-yaxawqhj 162 17 of of IN cord-023584-yaxawqhj 162 18 the the DT cord-023584-yaxawqhj 162 19 test test NN cord-023584-yaxawqhj 162 20 and and CC cord-023584-yaxawqhj 162 21 treating treat VBG cord-023584-yaxawqhj 162 22 them -PRON- PRP cord-023584-yaxawqhj 162 23 with with IN cord-023584-yaxawqhj 162 24 dcoxyribonuclease dcoxyribonuclease NNP cord-023584-yaxawqhj 162 25 when when WRB cord-023584-yaxawqhj 162 26 encapsulated encapsulate VBN cord-023584-yaxawqhj 162 27 virus virus NN cord-023584-yaxawqhj 162 28 DSA DSA NNP cord-023584-yaxawqhj 162 29 is be VBZ cord-023584-yaxawqhj 162 30 resistant resistant JJ cord-023584-yaxawqhj 162 31 to to IN cord-023584-yaxawqhj 162 32 digestion digestion NN cord-023584-yaxawqhj 162 33 and and CC cord-023584-yaxawqhj 162 34 the the DT cord-023584-yaxawqhj 162 35 unprotected unprotected JJ cord-023584-yaxawqhj 162 36 host host NN cord-023584-yaxawqhj 162 37 cell cell NN cord-023584-yaxawqhj 162 38 DSA DSA NNP cord-023584-yaxawqhj 162 39 is be VBZ cord-023584-yaxawqhj 162 40 not not RB cord-023584-yaxawqhj 162 41 . . . cord-023584-yaxawqhj 163 1 Thus thus RB cord-023584-yaxawqhj 163 2 , , , cord-023584-yaxawqhj 163 3 the the DT cord-023584-yaxawqhj 163 4 selective selective JJ cord-023584-yaxawqhj 163 5 effect effect NN cord-023584-yaxawqhj 163 6 of of IN cord-023584-yaxawqhj 163 7 test test NN cord-023584-yaxawqhj 163 8 compounds compound NNS cord-023584-yaxawqhj 163 9 on on IN cord-023584-yaxawqhj 163 10 the the DT cord-023584-yaxawqhj 163 11 synthesis synthesis NN cord-023584-yaxawqhj 163 12 of of IN cord-023584-yaxawqhj 163 13 virus virus NN cord-023584-yaxawqhj 163 14 DSA DSA NNP cord-023584-yaxawqhj 163 15 can can MD cord-023584-yaxawqhj 163 16 be be VB cord-023584-yaxawqhj 163 17 measured measure VBN cord-023584-yaxawqhj 163 18 . . . cord-023584-yaxawqhj 164 1 The the DT cord-023584-yaxawqhj 164 2 authors author NNS cord-023584-yaxawqhj 164 3 claim claim VBP cord-023584-yaxawqhj 164 4 that that IN cord-023584-yaxawqhj 164 5 the the DT cord-023584-yaxawqhj 164 6 system system NN cord-023584-yaxawqhj 164 7 operates operate VBZ cord-023584-yaxawqhj 164 8 satisfactorily satisfactorily RB cord-023584-yaxawqhj 164 9 ivith ivith VB cord-023584-yaxawqhj 164 10 a a DT cord-023584-yaxawqhj 164 11 range range NN cord-023584-yaxawqhj 164 12 of of IN cord-023584-yaxawqhj 164 13 viruses virus NNS cord-023584-yaxawqhj 164 14 - - : cord-023584-yaxawqhj 164 15 some some DT cord-023584-yaxawqhj 164 16 of of IN cord-023584-yaxawqhj 164 17 them -PRON- PRP cord-023584-yaxawqhj 164 18 important important JJ cord-023584-yaxawqhj 164 19 disease disease NN cord-023584-yaxawqhj 164 20 organisms organism NNS cord-023584-yaxawqhj 164 21 - - : cord-023584-yaxawqhj 164 22 and and CC cord-023584-yaxawqhj 164 23 is be VBZ cord-023584-yaxawqhj 164 24 simple simple JJ cord-023584-yaxawqhj 164 25 , , , cord-023584-yaxawqhj 164 26 reliable reliable JJ cord-023584-yaxawqhj 164 27 , , , cord-023584-yaxawqhj 164 28 and and CC cord-023584-yaxawqhj 164 29 rapid rapid JJ cord-023584-yaxawqhj 164 30 . . . cord-023584-yaxawqhj 165 1 The the DT cord-023584-yaxawqhj 165 2 chief chief JJ cord-023584-yaxawqhj 165 3 criticism criticism NN cord-023584-yaxawqhj 165 4 of of IN cord-023584-yaxawqhj 165 5 this this DT cord-023584-yaxawqhj 165 6 method method NN cord-023584-yaxawqhj 165 7 is be VBZ cord-023584-yaxawqhj 165 8 that that IN cord-023584-yaxawqhj 165 9 , , , cord-023584-yaxawqhj 165 10 because because IN cord-023584-yaxawqhj 165 11 nucleic nucleic JJ cord-023584-yaxawqhj 165 12 acid acid NN cord-023584-yaxawqhj 165 13 synthesis synthesis NN cord-023584-yaxawqhj 165 14 is be VBZ cord-023584-yaxawqhj 165 15 used use VBN cord-023584-yaxawqhj 165 16 as as IN cord-023584-yaxawqhj 165 17 the the DT cord-023584-yaxawqhj 165 18 sole sole JJ cord-023584-yaxawqhj 165 19 measure measure NN cord-023584-yaxawqhj 165 20 of of IN cord-023584-yaxawqhj 165 21 virus virus NN cord-023584-yaxawqhj 165 22 growth growth NN cord-023584-yaxawqhj 165 23 , , , cord-023584-yaxawqhj 165 24 test test NN cord-023584-yaxawqhj 165 25 compounds compound NNS cord-023584-yaxawqhj 165 26 that that WDT cord-023584-yaxawqhj 165 27 might may MD cord-023584-yaxawqhj 165 28 act act VB cord-023584-yaxawqhj 165 29 on on IN cord-023584-yaxawqhj 165 30 subsequent subsequent JJ cord-023584-yaxawqhj 165 31 stages stage NNS cord-023584-yaxawqhj 165 32 in in IN cord-023584-yaxawqhj 165 33 the the DT cord-023584-yaxawqhj 165 34 virus virus NN cord-023584-yaxawqhj 165 35 replicative replicative JJ cord-023584-yaxawqhj 165 36 cycle cycle NN cord-023584-yaxawqhj 165 37 may may MD cord-023584-yaxawqhj 165 38 not not RB cord-023584-yaxawqhj 165 39 be be VB cord-023584-yaxawqhj 165 40 detected detect VBN cord-023584-yaxawqhj 165 41 . . . cord-023584-yaxawqhj 166 1 For for IN cord-023584-yaxawqhj 166 2 example example NN cord-023584-yaxawqhj 166 3 , , , cord-023584-yaxawqhj 166 4 any any DT cord-023584-yaxawqhj 166 5 disturbances disturbance NNS cord-023584-yaxawqhj 166 6 in in IN cord-023584-yaxawqhj 166 7 the the DT cord-023584-yaxawqhj 166 8 sequencing sequencing NN cord-023584-yaxawqhj 166 9 of of IN cord-023584-yaxawqhj 166 10 virus virus NN cord-023584-yaxawqhj 166 11 nucleic nucleic JJ cord-023584-yaxawqhj 166 12 acid acid NN cord-023584-yaxawqhj 166 13 , , , cord-023584-yaxawqhj 166 14 inhibition inhibition NN cord-023584-yaxawqhj 166 15 of of IN cord-023584-yaxawqhj 166 16 structural structural JJ cord-023584-yaxawqhj 166 17 protein protein NN cord-023584-yaxawqhj 166 18 synthesis synthesis NN cord-023584-yaxawqhj 166 19 , , , cord-023584-yaxawqhj 166 20 or or CC cord-023584-yaxawqhj 166 21 failure failure NN cord-023584-yaxawqhj 166 22 of of IN cord-023584-yaxawqhj 166 23 assembly assembly NN cord-023584-yaxawqhj 166 24 or or CC cord-023584-yaxawqhj 166 25 release release NN cord-023584-yaxawqhj 166 26 of of IN cord-023584-yaxawqhj 166 27 mature mature JJ cord-023584-yaxawqhj 166 28 virions virion NNS cord-023584-yaxawqhj 166 29 , , , cord-023584-yaxawqhj 166 30 would would MD cord-023584-yaxawqhj 166 31 provide provide VB cord-023584-yaxawqhj 166 32 a a DT cord-023584-yaxawqhj 166 33 sound sound JJ cord-023584-yaxawqhj 166 34 basis basis NN cord-023584-yaxawqhj 166 35 for for IN cord-023584-yaxawqhj 166 36 a a DT cord-023584-yaxawqhj 166 37 useful useful JJ cord-023584-yaxawqhj 166 38 drug drug NN cord-023584-yaxawqhj 166 39 , , , cord-023584-yaxawqhj 166 40 but but CC cord-023584-yaxawqhj 166 41 these these DT cord-023584-yaxawqhj 166 42 phenomena phenomenon NNS cord-023584-yaxawqhj 166 43 may may MD cord-023584-yaxawqhj 166 44 not not RB cord-023584-yaxawqhj 166 45 be be VB cord-023584-yaxawqhj 166 46 detected detect VBN cord-023584-yaxawqhj 166 47 in in IN cord-023584-yaxawqhj 166 48 this this DT cord-023584-yaxawqhj 166 49 type type NN cord-023584-yaxawqhj 166 50 of of IN cord-023584-yaxawqhj 166 51 test test NN cord-023584-yaxawqhj 166 52 . . . cord-023584-yaxawqhj 167 1 Also also RB cord-023584-yaxawqhj 167 2 , , , cord-023584-yaxawqhj 167 3 since since IN cord-023584-yaxawqhj 167 4 high high JJ cord-023584-yaxawqhj 167 5 infecting infect VBG cord-023584-yaxawqhj 167 6 doses dose NNS cord-023584-yaxawqhj 167 7 of of IN cord-023584-yaxawqhj 167 8 virus virus NN cord-023584-yaxawqhj 167 9 are be VBP cord-023584-yaxawqhj 167 10 used use VBN cord-023584-yaxawqhj 167 11 to to TO cord-023584-yaxawqhj 167 12 give give VB cord-023584-yaxawqhj 167 13 satisfactory satisfactory JJ cord-023584-yaxawqhj 167 14 operation operation NN cord-023584-yaxawqhj 167 15 of of IN cord-023584-yaxawqhj 167 16 this this DT cord-023584-yaxawqhj 167 17 test test NN cord-023584-yaxawqhj 167 18 ( ( -LRB- cord-023584-yaxawqhj 167 19 up up IN cord-023584-yaxawqhj 167 20 to to TO cord-023584-yaxawqhj 167 21 15 15 CD cord-023584-yaxawqhj 167 22 virus virus NN cord-023584-yaxawqhj 167 23 particles particle NNS cord-023584-yaxawqhj 167 24 per per IN cord-023584-yaxawqhj 167 25 cell cell NN cord-023584-yaxawqhj 167 26 ) ) -RRB- cord-023584-yaxawqhj 167 27 , , , cord-023584-yaxawqhj 167 28 the the DT cord-023584-yaxawqhj 167 29 test test NN cord-023584-yaxawqhj 167 30 may may MD cord-023584-yaxawqhj 167 31 be be VB cord-023584-yaxawqhj 167 32 rather rather RB cord-023584-yaxawqhj 167 33 insensitive insensitive JJ cord-023584-yaxawqhj 167 34 in in IN cord-023584-yaxawqhj 167 35 detecting detect VBG cord-023584-yaxawqhj 167 36 antiviral antiviral JJ cord-023584-yaxawqhj 167 37 activity activity NN cord-023584-yaxawqhj 167 38 . . . cord-023584-yaxawqhj 168 1 All all DT cord-023584-yaxawqhj 168 2 antiviral antiviral JJ cord-023584-yaxawqhj 168 3 activity activity NN cord-023584-yaxawqhj 168 4 is be VBZ cord-023584-yaxawqhj 168 5 , , , cord-023584-yaxawqhj 168 6 in in IN cord-023584-yaxawqhj 168 7 the the DT cord-023584-yaxawqhj 168 8 broadest broad JJS cord-023584-yaxawqhj 168 9 sense sense NN cord-023584-yaxawqhj 168 10 , , , cord-023584-yaxawqhj 168 11 competitive competitive JJ cord-023584-yaxawqhj 168 12 , , , cord-023584-yaxawqhj 168 13 either either CC cord-023584-yaxawqhj 168 14 a a DT cord-023584-yaxawqhj 168 15 t t NN cord-023584-yaxawqhj 168 16 the the DT cord-023584-yaxawqhj 168 17 level level NN cord-023584-yaxawqhj 168 18 of of IN cord-023584-yaxawqhj 168 19 cellular cellular JJ cord-023584-yaxawqhj 168 20 membrane membrane NN cord-023584-yaxawqhj 168 21 receptors receptor NNS cord-023584-yaxawqhj 168 22 or or CC cord-023584-yaxawqhj 168 23 at at IN cord-023584-yaxawqhj 168 24 an an DT cord-023584-yaxawqhj 168 25 cnzymic cnzymic JJ cord-023584-yaxawqhj 168 26 or or CC cord-023584-yaxawqhj 168 27 template template NN cord-023584-yaxawqhj 168 28 level level NN cord-023584-yaxawqhj 168 29 . . . cord-023584-yaxawqhj 169 1 Thus thus RB cord-023584-yaxawqhj 169 2 , , , cord-023584-yaxawqhj 169 3 the the DT cord-023584-yaxawqhj 169 4 more more JJR cord-023584-yaxawqhj 169 5 virus virus NN cord-023584-yaxawqhj 169 6 is be VBZ cord-023584-yaxawqhj 169 7 used use VBN cord-023584-yaxawqhj 169 8 to to TO cord-023584-yaxawqhj 169 9 initiate initiate VB cord-023584-yaxawqhj 169 10 infection infection NN cord-023584-yaxawqhj 169 11 , , , cord-023584-yaxawqhj 169 12 the the DT cord-023584-yaxawqhj 169 13 less less RBR cord-023584-yaxawqhj 169 14 effective effective JJ cord-023584-yaxawqhj 169 15 an an DT cord-023584-yaxawqhj 169 16 antiviral antiviral JJ cord-023584-yaxawqhj 169 17 compound compound NN cord-023584-yaxawqhj 169 18 is be VBZ cord-023584-yaxawqhj 169 19 likely likely JJ cord-023584-yaxawqhj 169 20 to to TO cord-023584-yaxawqhj 169 21 be be VB cord-023584-yaxawqhj 169 22 . . . cord-023584-yaxawqhj 170 1 Although although IN cord-023584-yaxawqhj 170 2 this this DT cord-023584-yaxawqhj 170 3 factor factor NN cord-023584-yaxawqhj 170 4 will will MD cord-023584-yaxawqhj 170 5 not not RB cord-023584-yaxawqhj 170 6 turn turn VB cord-023584-yaxawqhj 170 7 a a DT cord-023584-yaxawqhj 170 8 highly highly RB cord-023584-yaxawqhj 170 9 active active JJ cord-023584-yaxawqhj 170 10 compound compound NN cord-023584-yaxawqhj 170 11 into into IN cord-023584-yaxawqhj 170 12 an an DT cord-023584-yaxawqhj 170 13 inactive inactive JJ cord-023584-yaxawqhj 170 14 one one NN cord-023584-yaxawqhj 170 15 , , , cord-023584-yaxawqhj 170 16 it -PRON- PRP cord-023584-yaxawqhj 170 17 may may MD cord-023584-yaxawqhj 170 18 well well RB cord-023584-yaxawqhj 170 19 obscure obscure JJ cord-023584-yaxawqhj 170 20 low low JJ cord-023584-yaxawqhj 170 21 levels level NNS cord-023584-yaxawqhj 170 22 of of IN cord-023584-yaxawqhj 170 23 activity activity NN cord-023584-yaxawqhj 170 24 which which WDT cord-023584-yaxawqhj 170 25 might may MD cord-023584-yaxawqhj 170 26 be be VB cord-023584-yaxawqhj 170 27 useful useful JJ cord-023584-yaxawqhj 170 28 starting start VBG cord-023584-yaxawqhj 170 29 points point NNS cord-023584-yaxawqhj 170 30 for for IN cord-023584-yaxawqhj 170 31 chemical chemical NN cord-023584-yaxawqhj 170 32 exploitation exploitation NN cord-023584-yaxawqhj 170 33 . . . cord-023584-yaxawqhj 171 1 The the DT cord-023584-yaxawqhj 171 2 real real JJ cord-023584-yaxawqhj 171 3 value value NN cord-023584-yaxawqhj 171 4 of of IN cord-023584-yaxawqhj 171 5 Miller Miller NNP cord-023584-yaxawqhj 171 6 's 's POS cord-023584-yaxawqhj 171 7 test test NN cord-023584-yaxawqhj 171 8 is be VBZ cord-023584-yaxawqhj 171 9 the the DT cord-023584-yaxawqhj 171 10 use use NN cord-023584-yaxawqhj 171 11 of of IN cord-023584-yaxawqhj 171 12 the the DT cord-023584-yaxawqhj 171 13 important important JJ cord-023584-yaxawqhj 171 14 biochemical biochemical JJ cord-023584-yaxawqhj 171 15 system system NN cord-023584-yaxawqhj 171 16 of of IN cord-023584-yaxawqhj 171 17 nucleic nucleic JJ cord-023584-yaxawqhj 171 18 acid acid NN cord-023584-yaxawqhj 171 19 synthesis synthesis NN cord-023584-yaxawqhj 171 20 to to TO cord-023584-yaxawqhj 171 21 monitor monitor VB cord-023584-yaxawqhj 171 22 the the DT cord-023584-yaxawqhj 171 23 toxic toxic JJ cord-023584-yaxawqhj 171 24 manifestations manifestation NNS cord-023584-yaxawqhj 171 25 of of IN cord-023584-yaxawqhj 171 26 test test NN cord-023584-yaxawqhj 171 27 compounds compound NNS cord-023584-yaxawqhj 171 28 . . . cord-023584-yaxawqhj 172 1 This this DT cord-023584-yaxawqhj 172 2 subject subject NN cord-023584-yaxawqhj 172 3 is be VBZ cord-023584-yaxawqhj 172 4 discussed discuss VBN cord-023584-yaxawqhj 172 5 furthrr furthrr NN cord-023584-yaxawqhj 172 6 in in IN cord-023584-yaxawqhj 172 7 the the DT cord-023584-yaxawqhj 172 8 following following JJ cord-023584-yaxawqhj 172 9 section section NN cord-023584-yaxawqhj 172 10 . . . cord-023584-yaxawqhj 173 1 Reference reference NN cord-023584-yaxawqhj 173 2 has have VBZ cord-023584-yaxawqhj 173 3 already already RB cord-023584-yaxawqhj 173 4 been be VBN cord-023584-yaxawqhj 173 5 made make VBN cord-023584-yaxawqhj 173 6 to to IN cord-023584-yaxawqhj 173 7 four four CD cord-023584-yaxawqhj 173 8 methods method NNS cord-023584-yaxawqhj 173 9 for for IN cord-023584-yaxawqhj 173 10 measuring measure VBG cord-023584-yaxawqhj 173 11 the the DT cord-023584-yaxawqhj 173 12 toxicity toxicity NN cord-023584-yaxawqhj 173 13 of of IN cord-023584-yaxawqhj 173 14 chemical chemical JJ cord-023584-yaxawqhj 173 15 compounds compound NNS cord-023584-yaxawqhj 173 16 in in IN cord-023584-yaxawqhj 173 17 tissue tissue NN cord-023584-yaxawqhj 173 18 culture culture NN cord-023584-yaxawqhj 173 19 cells cell NNS cord-023584-yaxawqhj 173 20 : : : cord-023584-yaxawqhj 173 21 direct direct JJ cord-023584-yaxawqhj 173 22 cytopathic cytopathic JJ cord-023584-yaxawqhj 173 23 ef ef NNP cord-023584-yaxawqhj 173 24 - - HYPH cord-023584-yaxawqhj 173 25 fects fects NNP cord-023584-yaxawqhj 173 26 , , , cord-023584-yaxawqhj 173 27 vital vital JJ cord-023584-yaxawqhj 173 28 dye dye NN cord-023584-yaxawqhj 173 29 uptake uptake NN cord-023584-yaxawqhj 173 30 , , , cord-023584-yaxawqhj 173 31 metabolic metabolic JJ cord-023584-yaxawqhj 173 32 activity activity NN cord-023584-yaxawqhj 173 33 ( ( -LRB- cord-023584-yaxawqhj 173 34 pH ph JJ cord-023584-yaxawqhj 173 35 - - HYPH cord-023584-yaxawqhj 173 36 swing swing NN cord-023584-yaxawqhj 173 37 ) ) -RRB- cord-023584-yaxawqhj 173 38 , , , cord-023584-yaxawqhj 173 39 and and CC cord-023584-yaxawqhj 173 40 nucleic nucleic JJ cord-023584-yaxawqhj 173 41 acid acid NN cord-023584-yaxawqhj 173 42 inhibition inhibition NN cord-023584-yaxawqhj 173 43 , , , cord-023584-yaxawqhj 173 44 and and CC cord-023584-yaxawqhj 173 45 there there EX cord-023584-yaxawqhj 173 46 is be VBZ cord-023584-yaxawqhj 173 47 no no DT cord-023584-yaxawqhj 173 48 shortage shortage NN cord-023584-yaxawqhj 173 49 of of IN cord-023584-yaxawqhj 173 50 other other JJ cord-023584-yaxawqhj 173 51 methods method NNS cord-023584-yaxawqhj 173 52 . . . cord-023584-yaxawqhj 174 1 Nevertheless nevertheless RB cord-023584-yaxawqhj 174 2 , , , cord-023584-yaxawqhj 174 3 the the DT cord-023584-yaxawqhj 174 4 inadequate inadequate JJ cord-023584-yaxawqhj 174 5 assessment assessment NN cord-023584-yaxawqhj 174 6 of of IN cord-023584-yaxawqhj 174 7 compound compound NN cord-023584-yaxawqhj 174 8 toxicity toxicity NN cord-023584-yaxawqhj 174 9 in in IN cord-023584-yaxawqhj 174 10 antiviral antiviral JJ cord-023584-yaxawqhj 174 11 testing testing NN cord-023584-yaxawqhj 174 12 probably probably RB cord-023584-yaxawqhj 174 13 gives give VBZ cord-023584-yaxawqhj 174 14 rise rise NN cord-023584-yaxawqhj 174 15 to to IN cord-023584-yaxawqhj 174 16 more more RBR cord-023584-yaxawqhj 174 17 false false JJ cord-023584-yaxawqhj 174 18 leads lead NNS cord-023584-yaxawqhj 174 19 than than IN cord-023584-yaxawqhj 174 20 any any DT cord-023584-yaxawqhj 174 21 other other JJ cord-023584-yaxawqhj 174 22 single single JJ cord-023584-yaxawqhj 174 23 cause cause NN cord-023584-yaxawqhj 174 24 , , , cord-023584-yaxawqhj 174 25 Before before IN cord-023584-yaxawqhj 174 26 discussing discuss VBG cord-023584-yaxawqhj 174 27 how how WRB cord-023584-yaxawqhj 174 28 compound compound JJ cord-023584-yaxawqhj 174 29 toxicity toxicity NN cord-023584-yaxawqhj 174 30 might may MD cord-023584-yaxawqhj 174 31 be be VB cord-023584-yaxawqhj 174 32 measured measure VBN cord-023584-yaxawqhj 174 33 , , , cord-023584-yaxawqhj 174 34 it -PRON- PRP cord-023584-yaxawqhj 174 35 must must MD cord-023584-yaxawqhj 174 36 first first RB cord-023584-yaxawqhj 174 37 be be VB cord-023584-yaxawqhj 174 38 defined define VBN cord-023584-yaxawqhj 174 39 . . . cord-023584-yaxawqhj 175 1 Strictly strictly RB cord-023584-yaxawqhj 175 2 , , , cord-023584-yaxawqhj 175 3 any any DT cord-023584-yaxawqhj 175 4 interference interference NN cord-023584-yaxawqhj 175 5 with with IN cord-023584-yaxawqhj 175 6 cellular cellular JJ cord-023584-yaxawqhj 175 7 metabolism metabolism NN cord-023584-yaxawqhj 175 8 by by IN cord-023584-yaxawqhj 175 9 an an DT cord-023584-yaxawqhj 175 10 extraneous extraneous JJ cord-023584-yaxawqhj 175 11 compound compound NN cord-023584-yaxawqhj 175 12 is be VBZ cord-023584-yaxawqhj 175 13 a a DT cord-023584-yaxawqhj 175 14 toxic toxic JJ cord-023584-yaxawqhj 175 15 effect effect NN cord-023584-yaxawqhj 175 16 , , , cord-023584-yaxawqhj 175 17 and and CC cord-023584-yaxawqhj 175 18 the the DT cord-023584-yaxawqhj 175 19 most most RBS cord-023584-yaxawqhj 175 20 stringent stringent JJ cord-023584-yaxawqhj 175 21 tissue tissue NN cord-023584-yaxawqhj 175 22 culture culture NN cord-023584-yaxawqhj 175 23 test test NN cord-023584-yaxawqhj 175 24 of of IN cord-023584-yaxawqhj 175 25 lack lack NN cord-023584-yaxawqhj 175 26 of of IN cord-023584-yaxawqhj 175 27 toxicity toxicity NN cord-023584-yaxawqhj 175 28 is be VBZ cord-023584-yaxawqhj 175 29 the the DT cord-023584-yaxawqhj 175 30 continued continued JJ cord-023584-yaxawqhj 175 31 normal normal JJ cord-023584-yaxawqhj 175 32 division division NN cord-023584-yaxawqhj 175 33 and and CC cord-023584-yaxawqhj 175 34 growth growth NN cord-023584-yaxawqhj 175 35 of of IN cord-023584-yaxawqhj 175 36 cells cell NNS cord-023584-yaxawqhj 175 37 in in IN cord-023584-yaxawqhj 175 38 the the DT cord-023584-yaxawqhj 175 39 presence presence NN cord-023584-yaxawqhj 175 40 of of IN cord-023584-yaxawqhj 175 41 an an DT cord-023584-yaxawqhj 175 42 extraneous extraneous JJ cord-023584-yaxawqhj 175 43 compound compound NN cord-023584-yaxawqhj 175 44 . . . cord-023584-yaxawqhj 176 1 However however RB cord-023584-yaxawqhj 176 2 , , , cord-023584-yaxawqhj 176 3 this this DT cord-023584-yaxawqhj 176 4 test test NN cord-023584-yaxawqhj 176 5 is be VBZ cord-023584-yaxawqhj 176 6 too too RB cord-023584-yaxawqhj 176 7 cumbersome cumbersome JJ cord-023584-yaxawqhj 176 8 for for IN cord-023584-yaxawqhj 176 9 use use NN cord-023584-yaxawqhj 176 10 in in IN cord-023584-yaxawqhj 176 11 rapid rapid JJ cord-023584-yaxawqhj 176 12 screening screening NN cord-023584-yaxawqhj 176 13 procedures procedure NNS cord-023584-yaxawqhj 176 14 , , , cord-023584-yaxawqhj 176 15 and and CC cord-023584-yaxawqhj 176 16 simpler simple JJR cord-023584-yaxawqhj 176 17 , , , cord-023584-yaxawqhj 176 18 but but CC cord-023584-yaxawqhj 176 19 less less RBR cord-023584-yaxawqhj 176 20 critical critical JJ cord-023584-yaxawqhj 176 21 , , , cord-023584-yaxawqhj 176 22 tests test NNS cord-023584-yaxawqhj 176 23 are be VBP cord-023584-yaxawqhj 176 24 invariably invariably RB cord-023584-yaxawqhj 176 25 used use VBN cord-023584-yaxawqhj 176 26 in in IN cord-023584-yaxawqhj 176 27 primary primary JJ cord-023584-yaxawqhj 176 28 screens screen NNS cord-023584-yaxawqhj 176 29 . . . cord-023584-yaxawqhj 177 1 Undoubtedly undoubtedly RB cord-023584-yaxawqhj 177 2 , , , cord-023584-yaxawqhj 177 3 the the DT cord-023584-yaxawqhj 177 4 simplest simple JJS cord-023584-yaxawqhj 177 5 method method NN cord-023584-yaxawqhj 177 6 of of IN cord-023584-yaxawqhj 177 7 assessing assess VBG cord-023584-yaxawqhj 177 8 compound compound NN cord-023584-yaxawqhj 177 9 toxicity toxicity NN cord-023584-yaxawqhj 177 10 is be VBZ cord-023584-yaxawqhj 177 11 by by IN cord-023584-yaxawqhj 177 12 direct direct JJ cord-023584-yaxawqhj 177 13 microscopic microscopic JJ cord-023584-yaxawqhj 177 14 examination examination NN cord-023584-yaxawqhj 177 15 of of IN cord-023584-yaxawqhj 177 16 cells cell NNS cord-023584-yaxawqhj 177 17 for for IN cord-023584-yaxawqhj 177 18 cytopathic cytopathic JJ cord-023584-yaxawqhj 177 19 effects effect NNS cord-023584-yaxawqhj 177 20 or or CC cord-023584-yaxawqhj 177 21 more more RBR cord-023584-yaxawqhj 177 22 subtle subtle JJ cord-023584-yaxawqhj 177 23 morphological morphological JJ cord-023584-yaxawqhj 177 24 changes change NNS cord-023584-yaxawqhj 177 25 . . . cord-023584-yaxawqhj 178 1 It -PRON- PRP cord-023584-yaxawqhj 178 2 is be VBZ cord-023584-yaxawqhj 178 3 necessary necessary JJ cord-023584-yaxawqhj 178 4 for for IN cord-023584-yaxawqhj 178 5 the the DT cord-023584-yaxawqhj 178 6 observer observer NN cord-023584-yaxawqhj 178 7 to to TO cord-023584-yaxawqhj 178 8 be be VB cord-023584-yaxawqhj 178 9 trained train VBN cord-023584-yaxawqhj 178 10 to to TO cord-023584-yaxawqhj 178 11 detect detect VB cord-023584-yaxawqhj 178 12 such such JJ cord-023584-yaxawqhj 178 13 changes change NNS cord-023584-yaxawqhj 178 14 , , , cord-023584-yaxawqhj 178 15 and and CC cord-023584-yaxawqhj 178 16 an an DT cord-023584-yaxawqhj 178 17 arbitrary arbitrary JJ cord-023584-yaxawqhj 178 18 scale scale NN cord-023584-yaxawqhj 178 19 must must MD cord-023584-yaxawqhj 178 20 be be VB cord-023584-yaxawqhj 178 21 devised devise VBN cord-023584-yaxawqhj 178 22 to to TO cord-023584-yaxawqhj 178 23 record record VB cord-023584-yaxawqhj 178 24 the the DT cord-023584-yaxawqhj 178 25 observations observation NNS cord-023584-yaxawqhj 178 26 , , , cord-023584-yaxawqhj 178 27 but but CC cord-023584-yaxawqhj 178 28 if if IN cord-023584-yaxawqhj 178 29 these these DT cord-023584-yaxawqhj 178 30 simple simple JJ cord-023584-yaxawqhj 178 31 requirements requirement NNS cord-023584-yaxawqhj 178 32 are be VBP cord-023584-yaxawqhj 178 33 met meet VBN cord-023584-yaxawqhj 178 34 , , , cord-023584-yaxawqhj 178 35 the the DT cord-023584-yaxawqhj 178 36 method method NN cord-023584-yaxawqhj 178 37 is be VBZ cord-023584-yaxawqhj 178 38 generally generally RB cord-023584-yaxawqhj 178 39 successful successful JJ cord-023584-yaxawqhj 178 40 . . . cord-023584-yaxawqhj 179 1 It -PRON- PRP cord-023584-yaxawqhj 179 2 may may MD cord-023584-yaxawqhj 179 3 be be VB cord-023584-yaxawqhj 179 4 objected object VBN cord-023584-yaxawqhj 179 5 that that IN cord-023584-yaxawqhj 179 6 this this DT cord-023584-yaxawqhj 179 7 system system NN cord-023584-yaxawqhj 179 8 would would MD cord-023584-yaxawqhj 179 9 be be VB cord-023584-yaxawqhj 179 10 unworkable unworkable JJ cord-023584-yaxawqhj 179 11 where where WRB cord-023584-yaxawqhj 179 12 large large JJ cord-023584-yaxawqhj 179 13 numbers number NNS cord-023584-yaxawqhj 179 14 of of IN cord-023584-yaxawqhj 179 15 compounds compound NNS cord-023584-yaxawqhj 179 16 are be VBP cord-023584-yaxawqhj 179 17 being be VBG cord-023584-yaxawqhj 179 18 screened screen VBN cord-023584-yaxawqhj 179 19 because because IN cord-023584-yaxawqhj 179 20 of of IN cord-023584-yaxawqhj 179 21 the the DT cord-023584-yaxawqhj 179 22 correspondingly correspondingly RB cord-023584-yaxawqhj 179 23 large large JJ cord-023584-yaxawqhj 179 24 numbers number NNS cord-023584-yaxawqhj 179 25 of of IN cord-023584-yaxawqhj 179 26 microscopic microscopic JJ cord-023584-yaxawqhj 179 27 examinations examination NNS cord-023584-yaxawqhj 179 28 required require VBN cord-023584-yaxawqhj 179 29 ; ; : cord-023584-yaxawqhj 179 30 but but CC cord-023584-yaxawqhj 179 31 given give VBN cord-023584-yaxawqhj 179 32 a a DT cord-023584-yaxawqhj 179 33 good good JJ cord-023584-yaxawqhj 179 34 low low JJ cord-023584-yaxawqhj 179 35 - - HYPH cord-023584-yaxawqhj 179 36 power power NN cord-023584-yaxawqhj 179 37 microscope microscope NN cord-023584-yaxawqhj 179 38 , , , cord-023584-yaxawqhj 179 39 an an DT cord-023584-yaxawqhj 179 40 experienced experienced JJ cord-023584-yaxawqhj 179 41 reader reader NN cord-023584-yaxawqhj 179 42 , , , cord-023584-yaxawqhj 179 43 and and CC cord-023584-yaxawqhj 179 44 the the DT cord-023584-yaxawqhj 179 45 fact fact NN cord-023584-yaxawqhj 179 46 that that IN cord-023584-yaxawqhj 179 47 most most JJS cord-023584-yaxawqhj 179 48 random random JJ cord-023584-yaxawqhj 179 49 compounds compound NNS cord-023584-yaxawqhj 179 50 tested test VBN cord-023584-yaxawqhj 179 51 will will MD cord-023584-yaxawqhj 179 52 show show VB cord-023584-yaxawqhj 179 53 no no DT cord-023584-yaxawqhj 179 54 antiviral antiviral JJ cord-023584-yaxawqhj 179 55 activity activity NN cord-023584-yaxawqhj 179 56 and and CC cord-023584-yaxawqhj 179 57 will will MD cord-023584-yaxawqhj 179 58 , , , cord-023584-yaxawqhj 179 59 therefore therefore RB cord-023584-yaxawqhj 179 60 , , , cord-023584-yaxawqhj 179 61 not not RB cord-023584-yaxawqhj 179 62 require require VB cord-023584-yaxawqhj 179 63 more more JJR cord-023584-yaxawqhj 179 64 than than IN cord-023584-yaxawqhj 179 65 a a DT cord-023584-yaxawqhj 179 66 cursory cursory JJ cord-023584-yaxawqhj 179 67 examination examination NN cord-023584-yaxawqhj 179 68 , , , cord-023584-yaxawqhj 179 69 the the DT cord-023584-yaxawqhj 179 70 system system NN cord-023584-yaxawqhj 179 71 is be VBZ cord-023584-yaxawqhj 179 72 reliable reliable JJ cord-023584-yaxawqhj 179 73 , , , cord-023584-yaxawqhj 179 74 fast fast JJ cord-023584-yaxawqhj 179 75 , , , cord-023584-yaxawqhj 179 76 and and CC cord-023584-yaxawqhj 179 77 economical economical JJ cord-023584-yaxawqhj 179 78 . . . cord-023584-yaxawqhj 180 1 In in IN cord-023584-yaxawqhj 180 2 the the DT cord-023584-yaxawqhj 180 3 author author NN cord-023584-yaxawqhj 180 4 's 's POS cord-023584-yaxawqhj 180 5 laboratory laboratory NN cord-023584-yaxawqhj 180 6 a a DT cord-023584-yaxawqhj 180 7 system system NN cord-023584-yaxawqhj 180 8 of of IN cord-023584-yaxawqhj 180 9 this this DT cord-023584-yaxawqhj 180 10 kind kind NN cord-023584-yaxawqhj 180 11 has have VBZ cord-023584-yaxawqhj 180 12 been be VBN cord-023584-yaxawqhj 180 13 in in IN cord-023584-yaxawqhj 180 14 use use NN cord-023584-yaxawqhj 180 15 for for IN cord-023584-yaxawqhj 180 16 over over IN cord-023584-yaxawqhj 180 17 5 5 CD cord-023584-yaxawqhj 180 18 years year NNS cord-023584-yaxawqhj 180 19 , , , cord-023584-yaxawqhj 180 20 and and CC cord-023584-yaxawqhj 180 21 it -PRON- PRP cord-023584-yaxawqhj 180 22 is be VBZ cord-023584-yaxawqhj 180 23 possible possible JJ cord-023584-yaxawqhj 180 24 for for IN cord-023584-yaxawqhj 180 25 one one CD cord-023584-yaxawqhj 180 26 worker worker NN cord-023584-yaxawqhj 180 27 to to TO cord-023584-yaxawqhj 180 28 screen screen VB cord-023584-yaxawqhj 180 29 a a DT cord-023584-yaxawqhj 180 30 hundred hundred CD cord-023584-yaxawqhj 180 31 compounds compound NNS cord-023584-yaxawqhj 180 32 against against IN cord-023584-yaxawqhj 180 33 three three CD cord-023584-yaxawqhj 180 34 viruses virus NNS cord-023584-yaxawqhj 180 35 each each DT cord-023584-yaxawqhj 180 36 week week NN cord-023584-yaxawqhj 180 37 . . . cord-023584-yaxawqhj 181 1 We -PRON- PRP cord-023584-yaxawqhj 181 2 have have VBP cord-023584-yaxawqhj 181 3 found find VBN cord-023584-yaxawqhj 181 4 that that IN cord-023584-yaxawqhj 181 5 with with IN cord-023584-yaxawqhj 181 6 this this DT cord-023584-yaxawqhj 181 7 system system NN cord-023584-yaxawqhj 181 8 , , , cord-023584-yaxawqhj 181 9 compounds compound NNS cord-023584-yaxawqhj 181 10 appear appear VBP cord-023584-yaxawqhj 181 11 to to TO cord-023584-yaxawqhj 181 12 be be VB cord-023584-yaxawqhj 181 13 toxic toxic JJ cord-023584-yaxawqhj 181 14 a a DT cord-023584-yaxawqhj 181 15 t t NN cord-023584-yaxawqhj 181 16 lower low JJR cord-023584-yaxawqhj 181 17 concentrations concentration NNS cord-023584-yaxawqhj 181 18 than than IN cord-023584-yaxawqhj 181 19 with with IN cord-023584-yaxawqhj 181 20 either either CC cord-023584-yaxawqhj 181 21 the the DT cord-023584-yaxawqhj 181 22 zone zone NN cord-023584-yaxawqhj 181 23 diffusion diffusion NN cord-023584-yaxawqhj 181 24 or or CC cord-023584-yaxawqhj 181 25 the the DT cord-023584-yaxawqhj 181 26 dye dye NN cord-023584-yaxawqhj 181 27 uptake uptake NN cord-023584-yaxawqhj 181 28 method method NN cord-023584-yaxawqhj 181 29 . . . cord-023584-yaxawqhj 182 1 We -PRON- PRP cord-023584-yaxawqhj 182 2 conclude conclude VBP cord-023584-yaxawqhj 182 3 , , , cord-023584-yaxawqhj 182 4 therefore therefore RB cord-023584-yaxawqhj 182 5 , , , cord-023584-yaxawqhj 182 6 that that IN cord-023584-yaxawqhj 182 7 our -PRON- PRP$ cord-023584-yaxawqhj 182 8 method method NN cord-023584-yaxawqhj 182 9 is be VBZ cord-023584-yaxawqhj 182 10 more more RBR cord-023584-yaxawqhj 182 11 sensitive sensitive JJ cord-023584-yaxawqhj 182 12 than than IN cord-023584-yaxawqhj 182 13 the the DT cord-023584-yaxawqhj 182 14 others other NNS cord-023584-yaxawqhj 182 15 mentioned mention VBD cord-023584-yaxawqhj 182 16 in in IN cord-023584-yaxawqhj 182 17 detecting detect VBG cord-023584-yaxawqhj 182 18 the the DT cord-023584-yaxawqhj 182 19 toxic toxic JJ cord-023584-yaxawqhj 182 20 effects effect NNS cord-023584-yaxawqhj 182 21 of of IN cord-023584-yaxawqhj 182 22 compounds compound NNS cord-023584-yaxawqhj 182 23 . . . cord-023584-yaxawqhj 183 1 The the DT cord-023584-yaxawqhj 183 2 direct direct JJ cord-023584-yaxawqhj 183 3 microscopic microscopic JJ cord-023584-yaxawqhj 183 4 assessment assessment NN cord-023584-yaxawqhj 183 5 of of IN cord-023584-yaxawqhj 183 6 toxicity toxicity NN cord-023584-yaxawqhj 183 7 is be VBZ cord-023584-yaxawqhj 183 8 not not RB cord-023584-yaxawqhj 183 9 without without IN cord-023584-yaxawqhj 183 10 its -PRON- PRP$ cord-023584-yaxawqhj 183 11 deficiencies deficiency NNS cord-023584-yaxawqhj 183 12 , , , cord-023584-yaxawqhj 183 13 but but CC cord-023584-yaxawqhj 183 14 if if IN cord-023584-yaxawqhj 183 15 the the DT cord-023584-yaxawqhj 183 16 method method NN cord-023584-yaxawqhj 183 17 is be VBZ cord-023584-yaxawqhj 183 18 seen see VBN cord-023584-yaxawqhj 183 19 only only RB cord-023584-yaxawqhj 183 20 as as IN cord-023584-yaxawqhj 183 21 a a DT cord-023584-yaxawqhj 183 22 preliminary preliminary JJ cord-023584-yaxawqhj 183 23 determination determination NN cord-023584-yaxawqhj 183 24 of of IN cord-023584-yaxawqhj 183 25 toxicity toxicity NN cord-023584-yaxawqhj 183 26 , , , cord-023584-yaxawqhj 183 27 these these DT cord-023584-yaxawqhj 183 28 deficiencies deficiency NNS cord-023584-yaxawqhj 183 29 are be VBP cord-023584-yaxawqhj 183 30 not not RB cord-023584-yaxawqhj 183 31 serious serious JJ cord-023584-yaxawqhj 183 32 . . . cord-023584-yaxawqhj 184 1 Chief chief JJ cord-023584-yaxawqhj 184 2 among among IN cord-023584-yaxawqhj 184 3 these these DT cord-023584-yaxawqhj 184 4 ( ( -LRB- cord-023584-yaxawqhj 184 5 and and CC cord-023584-yaxawqhj 184 6 this this DT cord-023584-yaxawqhj 184 7 applies apply VBZ cord-023584-yaxawqhj 184 8 even even RB cord-023584-yaxawqhj 184 9 more more RBR cord-023584-yaxawqhj 184 10 to to IN cord-023584-yaxawqhj 184 11 indirect indirect JJ cord-023584-yaxawqhj 184 12 methods method NNS cord-023584-yaxawqhj 184 13 ) ) -RRB- cord-023584-yaxawqhj 184 14 is be VBZ cord-023584-yaxawqhj 184 15 the the DT cord-023584-yaxawqhj 184 16 occasional occasional JJ cord-023584-yaxawqhj 184 17 failure failure NN cord-023584-yaxawqhj 184 18 to to TO cord-023584-yaxawqhj 184 19 detect detect VB cord-023584-yaxawqhj 184 20 certain certain JJ cord-023584-yaxawqhj 184 21 types type NNS cord-023584-yaxawqhj 184 22 of of IN cord-023584-yaxawqhj 184 23 toxicity toxicity NN cord-023584-yaxawqhj 184 24 . . . cord-023584-yaxawqhj 185 1 For for IN cord-023584-yaxawqhj 185 2 example example NN cord-023584-yaxawqhj 185 3 , , , cord-023584-yaxawqhj 185 4 from from IN cord-023584-yaxawqhj 185 5 time time NN cord-023584-yaxawqhj 185 6 to to IN cord-023584-yaxawqhj 185 7 time time NN cord-023584-yaxawqhj 185 8 we -PRON- PRP cord-023584-yaxawqhj 185 9 have have VBP cord-023584-yaxawqhj 185 10 had have VBN cord-023584-yaxawqhj 185 11 compounds compound NNS cord-023584-yaxawqhj 185 12 which which WDT cord-023584-yaxawqhj 185 13 appeared appear VBD cord-023584-yaxawqhj 185 14 to to TO cord-023584-yaxawqhj 185 15 prevent prevent VB cord-023584-yaxawqhj 185 16 virus virus NN cord-023584-yaxawqhj 185 17 growth growth NN cord-023584-yaxawqhj 185 18 and and CC cord-023584-yaxawqhj 185 19 to to TO cord-023584-yaxawqhj 185 20 show show VB cord-023584-yaxawqhj 185 21 no no DT cord-023584-yaxawqhj 185 22 toxicity toxicity NN cord-023584-yaxawqhj 185 23 to to IN cord-023584-yaxawqhj 185 24 confluent confluent JJ cord-023584-yaxawqhj 185 25 sheets sheet NNS cord-023584-yaxawqhj 185 26 of of IN cord-023584-yaxawqhj 185 27 tissue tissue NN cord-023584-yaxawqhj 185 28 culture culture NN cord-023584-yaxawqhj 185 29 cells cell NNS cord-023584-yaxawqhj 185 30 , , , cord-023584-yaxawqhj 185 31 These these DT cord-023584-yaxawqhj 185 32 cultures culture NNS cord-023584-yaxawqhj 185 33 looked look VBD cord-023584-yaxawqhj 185 34 normal normal JJ cord-023584-yaxawqhj 185 35 for for IN cord-023584-yaxawqhj 185 36 several several JJ cord-023584-yaxawqhj 185 37 days day NNS cord-023584-yaxawqhj 185 38 in in IN cord-023584-yaxawqhj 185 39 the the DT cord-023584-yaxawqhj 185 40 presence presence NN cord-023584-yaxawqhj 185 41 of of IN cord-023584-yaxawqhj 185 42 the the DT cord-023584-yaxawqhj 185 43 compound compound NN cord-023584-yaxawqhj 185 44 , , , cord-023584-yaxawqhj 185 45 but but CC cord-023584-yaxawqhj 185 46 viruses virus NNS cord-023584-yaxawqhj 185 47 would would MD cord-023584-yaxawqhj 185 48 not not RB cord-023584-yaxawqhj 185 49 grow grow VB cord-023584-yaxawqhj 185 50 in in IN cord-023584-yaxawqhj 185 51 these these DT cord-023584-yaxawqhj 185 52 cells cell NNS cord-023584-yaxawqhj 185 53 . . . cord-023584-yaxawqhj 186 1 Nevertheless nevertheless RB cord-023584-yaxawqhj 186 2 , , , cord-023584-yaxawqhj 186 3 further further JJ cord-023584-yaxawqhj 186 4 studies study NNS cord-023584-yaxawqhj 186 5 ( ( -LRB- cord-023584-yaxawqhj 186 6 see see VB cord-023584-yaxawqhj 186 7 below below RB cord-023584-yaxawqhj 186 8 ) ) -RRB- cord-023584-yaxawqhj 186 9 have have VBP cord-023584-yaxawqhj 186 10 shown show VBN cord-023584-yaxawqhj 186 11 that that IN cord-023584-yaxawqhj 186 12 the the DT cord-023584-yaxawqhj 186 13 compounds compound NNS cord-023584-yaxawqhj 186 14 were be VBD cord-023584-yaxawqhj 186 15 exerting exert VBG cord-023584-yaxawqhj 186 16 an an DT cord-023584-yaxawqhj 186 17 inhibitory inhibitory JJ cord-023584-yaxawqhj 186 18 effect effect NN cord-023584-yaxawqhj 186 19 on on IN cord-023584-yaxawqhj 186 20 some some DT cord-023584-yaxawqhj 186 21 aspect aspect NN cord-023584-yaxawqhj 186 22 of of IN cord-023584-yaxawqhj 186 23 the the DT cord-023584-yaxawqhj 186 24 cellular cellular JJ cord-023584-yaxawqhj 186 25 metabolism metabolism NN cord-023584-yaxawqhj 186 26 and and CC cord-023584-yaxawqhj 186 27 it -PRON- PRP cord-023584-yaxawqhj 186 28 was be VBD cord-023584-yaxawqhj 186 29 this this DT cord-023584-yaxawqhj 186 30 which which WDT cord-023584-yaxawqhj 186 31 prevented prevent VBD cord-023584-yaxawqhj 186 32 virus virus NN cord-023584-yaxawqhj 186 33 growth growth NN cord-023584-yaxawqhj 186 34 . . . cord-023584-yaxawqhj 187 1 We -PRON- PRP cord-023584-yaxawqhj 187 2 have have VBP cord-023584-yaxawqhj 187 3 investigated investigate VBN cord-023584-yaxawqhj 187 4 this this DT cord-023584-yaxawqhj 187 5 effect effect NN cord-023584-yaxawqhj 187 6 with with IN cord-023584-yaxawqhj 187 7 ( ( -LRB- cord-023584-yaxawqhj 187 8 a a DT cord-023584-yaxawqhj 187 9 ) ) -RRB- cord-023584-yaxawqhj 187 10 inhibitors inhibitor NNS cord-023584-yaxawqhj 187 11 of of IN cord-023584-yaxawqhj 187 12 nucleic nucleic JJ cord-023584-yaxawqhj 187 13 acid acid NN cord-023584-yaxawqhj 187 14 synthe synthe NNP cord-023584-yaxawqhj 187 15 - - HYPH cord-023584-yaxawqhj 187 16 sis sis NNP cord-023584-yaxawqhj 187 17 and and CC cord-023584-yaxawqhj 187 18 ( ( -LRB- cord-023584-yaxawqhj 187 19 b b NN cord-023584-yaxawqhj 187 20 ) ) -RRB- cord-023584-yaxawqhj 187 21 uncouplers uncoupler NNS cord-023584-yaxawqhj 187 22 of of IN cord-023584-yaxawqhj 187 23 oxidative oxidative JJ cord-023584-yaxawqhj 187 24 phosphorylation phosphorylation NN cord-023584-yaxawqhj 187 25 , , , cord-023584-yaxawqhj 187 26 two two CD cord-023584-yaxawqhj 187 27 classes class NNS cord-023584-yaxawqhj 187 28 of of IN cord-023584-yaxawqhj 187 29 compound compound NN cord-023584-yaxawqhj 187 30 that that WDT cord-023584-yaxawqhj 187 31 are be VBP cord-023584-yaxawqhj 187 32 particularly particularly RB cord-023584-yaxawqhj 187 33 prone prone JJ cord-023584-yaxawqhj 187 34 to to IN cord-023584-yaxawqhj 187 35 giving give VBG cord-023584-yaxawqhj 187 36 misleading misleading JJ cord-023584-yaxawqhj 187 37 results result NNS cord-023584-yaxawqhj 187 38 . . . cord-023584-yaxawqhj 188 1 Nucleic nucleic JJ cord-023584-yaxawqhj 188 2 acid acid NN cord-023584-yaxawqhj 188 3 inhibitors inhibitor NNS cord-023584-yaxawqhj 188 4 are be VBP cord-023584-yaxawqhj 188 5 often often RB cord-023584-yaxawqhj 188 6 slow slow JJ cord-023584-yaxawqhj 188 7 to to TO cord-023584-yaxawqhj 188 8 produce produce VB cord-023584-yaxawqhj 188 9 cytopathic cytopathic JJ cord-023584-yaxawqhj 188 10 effects effect NNS cord-023584-yaxawqhj 188 11 in in IN cord-023584-yaxawqhj 188 12 confluent confluent JJ cord-023584-yaxawqhj 188 13 monolayers monolayer NNS cord-023584-yaxawqhj 188 14 of of IN cord-023584-yaxawqhj 188 15 cultured cultured JJ cord-023584-yaxawqhj 188 16 cells cell NNS cord-023584-yaxawqhj 188 17 . . . cord-023584-yaxawqhj 189 1 The the DT cord-023584-yaxawqhj 189 2 D d NN cord-023584-yaxawqhj 189 3 S s NN cord-023584-yaxawqhj 190 1 A a DT cord-023584-yaxawqhj 190 2 synthrsis synthrsis NN cord-023584-yaxawqhj 190 3 of of IN cord-023584-yaxawqhj 190 4 such such JJ cord-023584-yaxawqhj 190 5 cells cell NNS cord-023584-yaxawqhj 190 6 is be VBZ cord-023584-yaxawqhj 190 7 low low JJ cord-023584-yaxawqhj 190 8 , , , cord-023584-yaxawqhj 190 9 and and CC cord-023584-yaxawqhj 190 10 sufficient sufficient JJ cord-023584-yaxawqhj 190 11 R r NN cord-023584-yaxawqhj 190 12 S s NN cord-023584-yaxawqhj 190 13 A a DT cord-023584-yaxawqhj 190 14 synthesis synthesis NN cord-023584-yaxawqhj 190 15 is be VBZ cord-023584-yaxawqhj 190 16 often often RB cord-023584-yaxawqhj 190 17 maintained maintain VBN cord-023584-yaxawqhj 190 18 in in IN cord-023584-yaxawqhj 190 19 the the DT cord-023584-yaxawqhj 190 20 presence presence NN cord-023584-yaxawqhj 190 21 of of IN cord-023584-yaxawqhj 190 22 partially partially RB cord-023584-yaxawqhj 190 23 effective effective JJ cord-023584-yaxawqhj 190 24 concentrations concentration NNS cord-023584-yaxawqhj 190 25 of of IN cord-023584-yaxawqhj 190 26 an an DT cord-023584-yaxawqhj 190 27 inhibitor inhibitor NN cord-023584-yaxawqhj 190 28 , , , cord-023584-yaxawqhj 190 29 enabling enable VBG cord-023584-yaxawqhj 190 30 the the DT cord-023584-yaxawqhj 190 31 cellular cellular JJ cord-023584-yaxawqhj 190 32 structural structural JJ cord-023584-yaxawqhj 190 33 integrity integrity NN cord-023584-yaxawqhj 190 34 to to TO cord-023584-yaxawqhj 190 35 be be VB cord-023584-yaxawqhj 190 36 sustained sustain VBN cord-023584-yaxawqhj 190 37 . . . cord-023584-yaxawqhj 191 1 All all PDT cord-023584-yaxawqhj 191 2 the the DT cord-023584-yaxawqhj 191 3 same same JJ cord-023584-yaxawqhj 191 4 , , , cord-023584-yaxawqhj 191 5 an an DT cord-023584-yaxawqhj 191 6 invading invade VBG cord-023584-yaxawqhj 191 7 virus virus NN cord-023584-yaxawqhj 191 8 is be VBZ cord-023584-yaxawqhj 191 9 unable unable JJ cord-023584-yaxawqhj 191 10 to to TO cord-023584-yaxawqhj 191 11 replicate replicate VB cord-023584-yaxawqhj 191 12 in in IN cord-023584-yaxawqhj 191 13 a a DT cord-023584-yaxawqhj 191 14 cell cell NN cord-023584-yaxawqhj 191 15 under under IN cord-023584-yaxawqhj 191 16 these these DT cord-023584-yaxawqhj 191 17 reduced reduce VBN cord-023584-yaxawqhj 191 18 circumstances circumstance NNS cord-023584-yaxawqhj 191 19 , , , cord-023584-yaxawqhj 191 20 and and CC cord-023584-yaxawqhj 191 21 this this DT cord-023584-yaxawqhj 191 22 will will MD cord-023584-yaxawqhj 191 23 lead lead VB cord-023584-yaxawqhj 191 24 to to IN cord-023584-yaxawqhj 191 25 an an DT cord-023584-yaxawqhj 191 26 apparent apparent JJ cord-023584-yaxawqhj 191 27 antiviral antiviral JJ cord-023584-yaxawqhj 191 28 specificity specificity NN cord-023584-yaxawqhj 191 29 . . . cord-023584-yaxawqhj 192 1 This this DT cord-023584-yaxawqhj 192 2 is be VBZ cord-023584-yaxawqhj 192 3 the the DT cord-023584-yaxawqhj 192 4 mechanism mechanism NN cord-023584-yaxawqhj 192 5 by by IN cord-023584-yaxawqhj 192 6 which which WDT cord-023584-yaxawqhj 192 7 the the DT cord-023584-yaxawqhj 192 8 chlorinated chlorinated JJ cord-023584-yaxawqhj 192 9 ribofuranosylbenzimidazoles ribofuranosylbenzimidazole NNS cord-023584-yaxawqhj 192 10 exert exert VBP cord-023584-yaxawqhj 192 11 their -PRON- PRP$ cord-023584-yaxawqhj 192 12 antiviral antiviral JJ cord-023584-yaxawqhj 192 13 effects effect NNS cord-023584-yaxawqhj 192 14 ( ( -LRB- cord-023584-yaxawqhj 192 15 Bucknall Bucknall NNP cord-023584-yaxawqhj 192 16 , , , cord-023584-yaxawqhj 192 17 1967 1967 CD cord-023584-yaxawqhj 192 18 ) ) -RRB- cord-023584-yaxawqhj 192 19 . . . cord-023584-yaxawqhj 193 1 These these DT cord-023584-yaxawqhj 193 2 compounds compound NNS cord-023584-yaxawqhj 193 3 were be VBD cord-023584-yaxawqhj 193 4 extensively extensively RB cord-023584-yaxawqhj 193 5 studied study VBN cord-023584-yaxawqhj 193 6 as as IN cord-023584-yaxawqhj 193 7 antiviral antiviral JJ cord-023584-yaxawqhj 193 8 agents agent NNS cord-023584-yaxawqhj 193 9 before before IN cord-023584-yaxawqhj 193 10 their -PRON- PRP$ cord-023584-yaxawqhj 193 11 " " `` cord-023584-yaxawqhj 193 12 activity activity NN cord-023584-yaxawqhj 193 13 " " '' cord-023584-yaxawqhj 193 14 was be VBD cord-023584-yaxawqhj 193 15 found find VBN cord-023584-yaxawqhj 193 16 not not RB cord-023584-yaxawqhj 193 17 to to TO cord-023584-yaxawqhj 193 18 be be VB cord-023584-yaxawqhj 193 19 specific specific JJ cord-023584-yaxawqhj 193 20 for for IN cord-023584-yaxawqhj 193 21 the the DT cord-023584-yaxawqhj 193 22 virus virus NN cord-023584-yaxawqhj 194 1 ( ( -LRB- cord-023584-yaxawqhj 194 2 Tamm Tamm NNP cord-023584-yaxawqhj 194 3 et et NNP cord-023584-yaxawqhj 194 4 al al NNP cord-023584-yaxawqhj 194 5 . . NNP cord-023584-yaxawqhj 194 6 , , , cord-023584-yaxawqhj 194 7 1954 1954 CD cord-023584-yaxawqhj 194 8 ; ; . cord-023584-yaxawqhj 195 1 Tamm Tamm NNP cord-023584-yaxawqhj 195 2 and and CC cord-023584-yaxawqhj 195 3 Srmes Srmes NNP cord-023584-yaxawqhj 195 4 , , , cord-023584-yaxawqhj 195 5 1957 1957 CD cord-023584-yaxawqhj 195 6 ; ; : cord-023584-yaxawqhj 195 7 Tamm Tamm NNP cord-023584-yaxawqhj 195 8 and and CC cord-023584-yaxawqhj 195 9 Overman Overman NNP cord-023584-yaxawqhj 195 10 , , , cord-023584-yaxawqhj 195 11 1957 1957 CD cord-023584-yaxawqhj 195 12 ) ) -RRB- cord-023584-yaxawqhj 195 13 . . . cord-023584-yaxawqhj 196 1 Uncouplers uncoupler NNS cord-023584-yaxawqhj 196 2 of of IN cord-023584-yaxawqhj 196 3 oxidative oxidative JJ cord-023584-yaxawqhj 196 4 phosphorylation phosphorylation NN cord-023584-yaxawqhj 196 5 also also RB cord-023584-yaxawqhj 196 6 often often RB cord-023584-yaxawqhj 196 7 appear appear VBP cord-023584-yaxawqhj 196 8 to to TO cord-023584-yaxawqhj 196 9 be be VB cord-023584-yaxawqhj 196 10 antiviral antiviral JJ cord-023584-yaxawqhj 196 11 agents agent NNS cord-023584-yaxawqhj 196 12 becausc becausc NNP cord-023584-yaxawqhj 196 13 concentrations concentration NNS cord-023584-yaxawqhj 196 14 that that WDT cord-023584-yaxawqhj 196 15 greatly greatly RB cord-023584-yaxawqhj 196 16 reduce reduce VBP cord-023584-yaxawqhj 196 17 the the DT cord-023584-yaxawqhj 196 18 energy energy NN cord-023584-yaxawqhj 196 19 - - HYPH cord-023584-yaxawqhj 196 20 generating generate VBG cord-023584-yaxawqhj 196 21 systems system NNS cord-023584-yaxawqhj 196 22 of of IN cord-023584-yaxawqhj 196 23 cells cell NNS cord-023584-yaxawqhj 196 24 in in IN cord-023584-yaxawqhj 196 25 confluent confluent JJ cord-023584-yaxawqhj 196 26 monolayers monolayer NNS cord-023584-yaxawqhj 196 27 are be VBP cord-023584-yaxawqhj 196 28 often often RB cord-023584-yaxawqhj 196 29 slow slow JJ cord-023584-yaxawqhj 196 30 to to TO cord-023584-yaxawqhj 196 31 produce produce VB cord-023584-yaxawqhj 196 32 morphological morphological JJ cord-023584-yaxawqhj 196 33 changes change NNS cord-023584-yaxawqhj 196 34 . . . cord-023584-yaxawqhj 197 1 In in IN cord-023584-yaxawqhj 197 2 this this DT cord-023584-yaxawqhj 197 3 half half RB cord-023584-yaxawqhj 197 4 - - HYPH cord-023584-yaxawqhj 197 5 poisoned poison VBN cord-023584-yaxawqhj 197 6 state state NN cord-023584-yaxawqhj 197 7 , , , cord-023584-yaxawqhj 197 8 the the DT cord-023584-yaxawqhj 197 9 cultures culture NNS cord-023584-yaxawqhj 197 10 appear appear VBP cord-023584-yaxawqhj 197 11 normal normal JJ cord-023584-yaxawqhj 197 12 , , , cord-023584-yaxawqhj 197 13 but but CC cord-023584-yaxawqhj 197 14 do do VBP cord-023584-yaxawqhj 197 15 not not RB cord-023584-yaxawqhj 197 16 support support VB cord-023584-yaxawqhj 197 17 virus virus NN cord-023584-yaxawqhj 197 18 growth growth NN cord-023584-yaxawqhj 197 19 , , , cord-023584-yaxawqhj 197 20 and and CC cord-023584-yaxawqhj 197 21 thus thus RB cord-023584-yaxawqhj 197 22 another another DT cord-023584-yaxawqhj 197 23 false false JJ cord-023584-yaxawqhj 197 24 " " `` cord-023584-yaxawqhj 197 25 lead lead NN cord-023584-yaxawqhj 197 26 compound compound NN cord-023584-yaxawqhj 197 27 " " '' cord-023584-yaxawqhj 197 28 is be VBZ cord-023584-yaxawqhj 197 29 generated generate VBN cord-023584-yaxawqhj 197 30 . . . cord-023584-yaxawqhj 198 1 As as IN cord-023584-yaxawqhj 198 2 mentioned mention VBN cord-023584-yaxawqhj 198 3 earlier early RBR cord-023584-yaxawqhj 198 4 , , , cord-023584-yaxawqhj 198 5 these these DT cord-023584-yaxawqhj 198 6 remarks remark NNS cord-023584-yaxawqhj 198 7 apply apply VBP cord-023584-yaxawqhj 198 8 to to IN cord-023584-yaxawqhj 198 9 all all DT cord-023584-yaxawqhj 198 10 tissue tissue NN cord-023584-yaxawqhj 198 11 culture culture NN cord-023584-yaxawqhj 198 12 systems system NNS cord-023584-yaxawqhj 198 13 to to IN cord-023584-yaxawqhj 198 14 a a DT cord-023584-yaxawqhj 198 15 greater great JJR cord-023584-yaxawqhj 198 16 or or CC cord-023584-yaxawqhj 198 17 lesser less JJR cord-023584-yaxawqhj 198 18 extent extent NN cord-023584-yaxawqhj 198 19 , , , cord-023584-yaxawqhj 198 20 and and CC cord-023584-yaxawqhj 198 21 tissue tissue NN cord-023584-yaxawqhj 198 22 culture culture NN cord-023584-yaxawqhj 198 23 tests test NNS cord-023584-yaxawqhj 198 24 for for IN cord-023584-yaxawqhj 198 25 antiviral antiviral JJ cord-023584-yaxawqhj 198 26 activity activity NN cord-023584-yaxawqhj 198 27 must must MD cord-023584-yaxawqhj 198 28 always always RB cord-023584-yaxawqhj 198 29 be be VB cord-023584-yaxawqhj 198 30 regarded regard VBN cord-023584-yaxawqhj 198 31 as as RB cord-023584-yaxawqhj 198 32 strictly strictly RB cord-023584-yaxawqhj 198 33 preliminary preliminary JJ cord-023584-yaxawqhj 198 34 . . . cord-023584-yaxawqhj 199 1 Active active JJ cord-023584-yaxawqhj 199 2 leads lead VBZ cord-023584-yaxawqhj 199 3 from from IN cord-023584-yaxawqhj 199 4 such such JJ cord-023584-yaxawqhj 199 5 tests test NNS cord-023584-yaxawqhj 199 6 must must MD cord-023584-yaxawqhj 199 7 always always RB cord-023584-yaxawqhj 199 8 be be VB cord-023584-yaxawqhj 199 9 subjected subject VBN cord-023584-yaxawqhj 199 10 to to IN cord-023584-yaxawqhj 199 11 the the DT cord-023584-yaxawqhj 199 12 closest close JJS cord-023584-yaxawqhj 199 13 scrutiny scrutiny NN cord-023584-yaxawqhj 199 14 to to TO cord-023584-yaxawqhj 199 15 determine determine VB cord-023584-yaxawqhj 199 16 whether whether IN cord-023584-yaxawqhj 199 17 the the DT cord-023584-yaxawqhj 199 18 activity activity NN cord-023584-yaxawqhj 199 19 is be VBZ cord-023584-yaxawqhj 199 20 truly truly RB cord-023584-yaxawqhj 199 21 specific specific JJ cord-023584-yaxawqhj 199 22 for for IN cord-023584-yaxawqhj 199 23 a a DT cord-023584-yaxawqhj 199 24 virus virus NN cord-023584-yaxawqhj 199 25 - - HYPH cord-023584-yaxawqhj 199 26 coded code VBN cord-023584-yaxawqhj 199 27 process process NN cord-023584-yaxawqhj 199 28 or or CC cord-023584-yaxawqhj 199 29 simply simply RB cord-023584-yaxawqhj 199 30 results result VBZ cord-023584-yaxawqhj 199 31 from from IN cord-023584-yaxawqhj 199 32 a a DT cord-023584-yaxawqhj 199 33 subtle subtle JJ cord-023584-yaxawqhj 199 34 toxic toxic JJ cord-023584-yaxawqhj 199 35 effect effect NN cord-023584-yaxawqhj 199 36 on on IN cord-023584-yaxawqhj 199 37 the the DT cord-023584-yaxawqhj 199 38 host host NN cord-023584-yaxawqhj 199 39 cell cell NN cord-023584-yaxawqhj 199 40 . . . cord-023584-yaxawqhj 200 1 The the DT cord-023584-yaxawqhj 200 2 margin margin NN cord-023584-yaxawqhj 200 3 betwen betwen IN cord-023584-yaxawqhj 200 4 the the DT cord-023584-yaxawqhj 200 5 maximum maximum JJ cord-023584-yaxawqhj 200 6 nontoxic nontoxic JJ cord-023584-yaxawqhj 200 7 concentration concentration NN cord-023584-yaxawqhj 200 8 and and CC cord-023584-yaxawqhj 200 9 the the DT cord-023584-yaxawqhj 200 10 minimum minimum JJ cord-023584-yaxawqhj 200 11 antiviral antiviral JJ cord-023584-yaxawqhj 200 12 concentration concentration NN cord-023584-yaxawqhj 200 13 of of IN cord-023584-yaxawqhj 200 14 a a DT cord-023584-yaxawqhj 200 15 test test NN cord-023584-yaxawqhj 200 16 compound compound NN cord-023584-yaxawqhj 200 17 is be VBZ cord-023584-yaxawqhj 200 18 conveniently conveniently RB cord-023584-yaxawqhj 200 19 expressed express VBN cord-023584-yaxawqhj 200 20 as as IN cord-023584-yaxawqhj 200 21 thrrapcutie thrrapcutie NN cord-023584-yaxawqhj 200 22 ratio ratio NN cord-023584-yaxawqhj 200 23 = = SYM cord-023584-yaxawqhj 200 24 max max NN cord-023584-yaxawqhj 200 25 . . . cord-023584-yaxawqhj 201 1 nontoxic nontoxic JJ cord-023584-yaxawqhj 201 2 concentration concentration NN cord-023584-yaxawqhj 201 3 / / SYM cord-023584-yaxawqhj 201 4 min min NN cord-023584-yaxawqhj 201 5 . . . cord-023584-yaxawqhj 202 1 antiviral antiviral JJ cord-023584-yaxawqhj 202 2 concentration concentration NN cord-023584-yaxawqhj 202 3 and and CC cord-023584-yaxawqhj 202 4 will will MD cord-023584-yaxawqhj 202 5 vary vary VB cord-023584-yaxawqhj 202 6 according accord VBG cord-023584-yaxawqhj 202 7 to to IN cord-023584-yaxawqhj 202 8 how how WRB cord-023584-yaxawqhj 202 9 these these DT cord-023584-yaxawqhj 202 10 two two CD cord-023584-yaxawqhj 202 11 concentrations concentration NNS cord-023584-yaxawqhj 202 12 are be VBP cord-023584-yaxawqhj 202 13 determined determined JJ cord-023584-yaxawqhj 202 14 . . . cord-023584-yaxawqhj 203 1 The the DT cord-023584-yaxawqhj 203 2 simplest simple JJS cord-023584-yaxawqhj 203 3 and and CC cord-023584-yaxawqhj 203 4 most most RBS cord-023584-yaxawqhj 203 5 stringent stringent JJ cord-023584-yaxawqhj 203 6 test test NN cord-023584-yaxawqhj 203 7 of of IN cord-023584-yaxawqhj 203 8 the the DT cord-023584-yaxawqhj 203 9 maximum maximum JJ cord-023584-yaxawqhj 203 10 nontoxic nontoxic JJ cord-023584-yaxawqhj 203 11 concentration concentration NN cord-023584-yaxawqhj 203 12 of of IN cord-023584-yaxawqhj 203 13 a a DT cord-023584-yaxawqhj 203 14 compound compound NN cord-023584-yaxawqhj 203 15 in in IN cord-023584-yaxawqhj 203 16 zdtro zdtro NNP cord-023584-yaxawqhj 203 17 is be VBZ cord-023584-yaxawqhj 203 18 to to TO cord-023584-yaxawqhj 203 19 grow grow VB cord-023584-yaxawqhj 203 20 cells cell NNS cord-023584-yaxawqhj 203 21 in in IN cord-023584-yaxawqhj 203 22 the the DT cord-023584-yaxawqhj 203 23 presence presence NN cord-023584-yaxawqhj 203 24 of of IN cord-023584-yaxawqhj 203 25 the the DT cord-023584-yaxawqhj 203 26 compound compound NN cord-023584-yaxawqhj 203 27 and and CC cord-023584-yaxawqhj 203 28 determine determine VB cord-023584-yaxawqhj 203 29 the the DT cord-023584-yaxawqhj 203 30 maximum maximum JJ cord-023584-yaxawqhj 203 31 concentration concentration NN cord-023584-yaxawqhj 203 32 a a DT cord-023584-yaxawqhj 203 33 t t NN cord-023584-yaxawqhj 203 34 which which WDT cord-023584-yaxawqhj 203 35 division division NN cord-023584-yaxawqhj 203 36 and and CC cord-023584-yaxawqhj 203 37 growth growth NN cord-023584-yaxawqhj 203 38 will will MD cord-023584-yaxawqhj 203 39 proceed proceed VB cord-023584-yaxawqhj 203 40 normally normally RB cord-023584-yaxawqhj 203 41 . . . cord-023584-yaxawqhj 204 1 If if IN cord-023584-yaxawqhj 204 2 this this DT cord-023584-yaxawqhj 204 3 concentration concentration NN cord-023584-yaxawqhj 204 4 , , , cord-023584-yaxawqhj 204 5 and and CC cord-023584-yaxawqhj 204 6 lower low JJR cord-023584-yaxawqhj 204 7 ones one NNS cord-023584-yaxawqhj 204 8 , , , cord-023584-yaxawqhj 204 9 protect protect VB cord-023584-yaxawqhj 204 10 the the DT cord-023584-yaxawqhj 204 11 cells cell NNS cord-023584-yaxawqhj 204 12 from from IN cord-023584-yaxawqhj 204 13 virus virus NN cord-023584-yaxawqhj 204 14 attack attack NN cord-023584-yaxawqhj 204 15 , , , cord-023584-yaxawqhj 204 16 then then RB cord-023584-yaxawqhj 204 17 this this DT cord-023584-yaxawqhj 204 18 is be VBZ cord-023584-yaxawqhj 204 19 an an DT cord-023584-yaxawqhj 204 20 unequivocal unequivocal JJ cord-023584-yaxawqhj 204 21 demonstration demonstration NN cord-023584-yaxawqhj 204 22 that that WDT cord-023584-yaxawqhj 204 23 the the DT cord-023584-yaxawqhj 204 24 compound compound NN cord-023584-yaxawqhj 204 25 is be VBZ cord-023584-yaxawqhj 204 26 exerting exert VBG cord-023584-yaxawqhj 204 27 a a DT cord-023584-yaxawqhj 204 28 specific specific JJ cord-023584-yaxawqhj 204 29 effect effect NN cord-023584-yaxawqhj 204 30 on on IN cord-023584-yaxawqhj 204 31 some some DT cord-023584-yaxawqhj 204 32 aspect aspect NN cord-023584-yaxawqhj 204 33 of of IN cord-023584-yaxawqhj 204 34 virus virus NN cord-023584-yaxawqhj 204 35 replicat replicat NN cord-023584-yaxawqhj 204 36 ion ion NN cord-023584-yaxawqhj 204 37 . . . cord-023584-yaxawqhj 205 1 Like like IN cord-023584-yaxawqhj 205 2 Miller Miller NNP cord-023584-yaxawqhj 205 3 et et NNP cord-023584-yaxawqhj 205 4 al al NNP cord-023584-yaxawqhj 205 5 . . . cord-023584-yaxawqhj 206 1 ( ( -LRB- cord-023584-yaxawqhj 206 2 1970 1970 CD cord-023584-yaxawqhj 206 3 ) ) -RRB- cord-023584-yaxawqhj 206 4 , , , cord-023584-yaxawqhj 206 5 we -PRON- PRP cord-023584-yaxawqhj 206 6 have have VBP cord-023584-yaxawqhj 206 7 found find VBN cord-023584-yaxawqhj 206 8 the the DT cord-023584-yaxawqhj 206 9 inhibition inhibition NN cord-023584-yaxawqhj 206 10 of of IN cord-023584-yaxawqhj 206 11 cellular cellular JJ cord-023584-yaxawqhj 206 12 nucleic nucleic JJ cord-023584-yaxawqhj 206 13 acid acid NN cord-023584-yaxawqhj 206 14 synthesis synthesis NN cord-023584-yaxawqhj 206 15 , , , cord-023584-yaxawqhj 206 16 particularly particularly RB cord-023584-yaxawqhj 206 17 R R NNP cord-023584-yaxawqhj 206 18 S S NNP cord-023584-yaxawqhj 206 19 A a DT cord-023584-yaxawqhj 206 20 synthesis synthesis NN cord-023584-yaxawqhj 206 21 , , , cord-023584-yaxawqhj 206 22 to to TO cord-023584-yaxawqhj 206 23 be be VB cord-023584-yaxawqhj 206 24 a a DT cord-023584-yaxawqhj 206 25 useful useful JJ cord-023584-yaxawqhj 206 26 system system NN cord-023584-yaxawqhj 206 27 for for IN cord-023584-yaxawqhj 206 28 detecting detect VBG cord-023584-yaxawqhj 206 29 the the DT cord-023584-yaxawqhj 206 30 toxic toxic JJ cord-023584-yaxawqhj 206 31 effects effect NNS cord-023584-yaxawqhj 206 32 of of IN cord-023584-yaxawqhj 206 33 test test NN cord-023584-yaxawqhj 206 34 compounds compound NNS cord-023584-yaxawqhj 206 35 . . . cord-023584-yaxawqhj 207 1 Cells cell NNS cord-023584-yaxawqhj 207 2 are be VBP cord-023584-yaxawqhj 207 3 treated treat VBN cord-023584-yaxawqhj 207 4 with with IN cord-023584-yaxawqhj 207 5 a a DT cord-023584-yaxawqhj 207 6 range range NN cord-023584-yaxawqhj 207 7 of of IN cord-023584-yaxawqhj 207 8 concentrations concentration NNS cord-023584-yaxawqhj 207 9 of of IN cord-023584-yaxawqhj 207 10 a a DT cord-023584-yaxawqhj 207 11 compound compound NN cord-023584-yaxawqhj 207 12 , , , cord-023584-yaxawqhj 207 13 then then RB cord-023584-yaxawqhj 207 14 the the DT cord-023584-yaxawqhj 207 15 uptake uptake NN cord-023584-yaxawqhj 207 16 of of IN cord-023584-yaxawqhj 207 17 ~r ~r XX cord-023584-yaxawqhj 208 1 i i PRP cord-023584-yaxawqhj 208 2 d d NNP cord-023584-yaxawqhj 208 3 i i NNP cord-023584-yaxawqhj 208 4 n n NN cord-023584-yaxawqhj 208 5 e e NN cord-023584-yaxawqhj 209 1 -~H -~h IN cord-023584-yaxawqhj 209 2 into into IN cord-023584-yaxawqhj 209 3 acidinsoluble acidinsoluble JJ cord-023584-yaxawqhj 209 4 material material NN cord-023584-yaxawqhj 209 5 is be VBZ cord-023584-yaxawqhj 209 6 measured measure VBN cord-023584-yaxawqhj 209 7 and and CC cord-023584-yaxawqhj 209 8 compared compare VBN cord-023584-yaxawqhj 209 9 with with IN cord-023584-yaxawqhj 209 10 that that DT cord-023584-yaxawqhj 209 11 of of IN cord-023584-yaxawqhj 209 12 normal normal JJ cord-023584-yaxawqhj 209 13 cells cell NNS cord-023584-yaxawqhj 209 14 ( ( -LRB- cord-023584-yaxawqhj 209 15 Bucknall Bucknall NNP cord-023584-yaxawqhj 209 16 , , , cord-023584-yaxawqhj 209 17 1967 1967 CD cord-023584-yaxawqhj 209 18 ) ) -RRB- cord-023584-yaxawqhj 209 19 . . . cord-023584-yaxawqhj 210 1 The the DT cord-023584-yaxawqhj 210 2 test test NN cord-023584-yaxawqhj 210 3 is be VBZ cord-023584-yaxawqhj 210 4 simple simple JJ cord-023584-yaxawqhj 210 5 to to TO cord-023584-yaxawqhj 210 6 run run VB cord-023584-yaxawqhj 210 7 , , , cord-023584-yaxawqhj 210 8 and and CC cord-023584-yaxawqhj 210 9 since since IN cord-023584-yaxawqhj 210 10 the the DT cord-023584-yaxawqhj 210 11 nucleic nucleic JJ cord-023584-yaxawqhj 210 12 acid acid NN cord-023584-yaxawqhj 210 13 metabolism metabolism NN cord-023584-yaxawqhj 210 14 is be VBZ cord-023584-yaxawqhj 210 15 a a DT cord-023584-yaxawqhj 210 16 cardinal cardinal JJ cord-023584-yaxawqhj 210 17 area area NN cord-023584-yaxawqhj 210 18 in in IN cord-023584-yaxawqhj 210 19 the the DT cord-023584-yaxawqhj 210 20 cellular cellular JJ cord-023584-yaxawqhj 210 21 metabolism metabolism NN cord-023584-yaxawqhj 210 22 , , , cord-023584-yaxawqhj 210 23 even even RB cord-023584-yaxawqhj 210 24 if if IN cord-023584-yaxawqhj 210 25 a a DT cord-023584-yaxawqhj 210 26 compound compound NN cord-023584-yaxawqhj 210 27 has have VBZ cord-023584-yaxawqhj 210 28 no no DT cord-023584-yaxawqhj 210 29 direct direct JJ cord-023584-yaxawqhj 210 30 effect effect NN cord-023584-yaxawqhj 210 31 on on IN cord-023584-yaxawqhj 210 32 the the DT cord-023584-yaxawqhj 210 33 nucleic nucleic JJ cord-023584-yaxawqhj 210 34 acid acid NN cord-023584-yaxawqhj 210 35 synthesis synthesis NN cord-023584-yaxawqhj 210 36 , , , cord-023584-yaxawqhj 210 37 disturbances disturbance NNS cord-023584-yaxawqhj 210 38 of of IN cord-023584-yaxawqhj 210 39 other other JJ cord-023584-yaxawqhj 210 40 synthetic synthetic JJ cord-023584-yaxawqhj 210 41 or or CC cord-023584-yaxawqhj 210 42 homeostatic homeostatic JJ cord-023584-yaxawqhj 210 43 mechanisms mechanism NNS cord-023584-yaxawqhj 210 44 are be VBP cord-023584-yaxawqhj 210 45 quickly quickly RB cord-023584-yaxawqhj 210 46 reflected reflect VBN cord-023584-yaxawqhj 210 47 in in IN cord-023584-yaxawqhj 210 48 changes change NNS cord-023584-yaxawqhj 210 49 in in IN cord-023584-yaxawqhj 210 50 the the DT cord-023584-yaxawqhj 210 51 synthesis synthesis NN cord-023584-yaxawqhj 210 52 of of IN cord-023584-yaxawqhj 210 53 RNA RNA NNP cord-023584-yaxawqhj 210 54 or or CC cord-023584-yaxawqhj 210 55 DNA DNA NNP cord-023584-yaxawqhj 210 56 or or CC cord-023584-yaxawqhj 210 57 both both DT cord-023584-yaxawqhj 210 58 . . . cord-023584-yaxawqhj 211 1 In in IN cord-023584-yaxawqhj 211 2 Fig Fig NNP cord-023584-yaxawqhj 211 3 . . . cord-023584-yaxawqhj 212 1 1 1 LS cord-023584-yaxawqhj 212 2 , , , cord-023584-yaxawqhj 212 3 the the DT cord-023584-yaxawqhj 212 4 dose dose NN cord-023584-yaxawqhj 212 5 - - HYPH cord-023584-yaxawqhj 212 6 response response NN cord-023584-yaxawqhj 212 7 curves curve NNS cord-023584-yaxawqhj 212 8 of of IN cord-023584-yaxawqhj 212 9 one one CD cord-023584-yaxawqhj 212 10 experimental experimental JJ cord-023584-yaxawqhj 212 11 compound compound NN cord-023584-yaxawqhj 212 12 are be VBP cord-023584-yaxawqhj 212 13 determined determine VBN cord-023584-yaxawqhj 212 14 in in IN cord-023584-yaxawqhj 212 15 human human JJ cord-023584-yaxawqhj 212 16 diploid diploid JJ cord-023584-yaxawqhj 212 17 lung lung NN cord-023584-yaxawqhj 212 18 cells cell NNS cord-023584-yaxawqhj 212 19 by by IN cord-023584-yaxawqhj 212 20 the the DT cord-023584-yaxawqhj 212 21 three three CD cord-023584-yaxawqhj 212 22 methods method NNS cord-023584-yaxawqhj 212 23 outlined outline VBN cord-023584-yaxawqhj 212 24 above above RB cord-023584-yaxawqhj 212 25 - - HYPH cord-023584-yaxawqhj 212 26 direct direct JJ cord-023584-yaxawqhj 212 27 cytopathic cytopathic JJ cord-023584-yaxawqhj 212 28 effect effect NN cord-023584-yaxawqhj 212 29 in in IN cord-023584-yaxawqhj 212 30 confluent confluent JJ cord-023584-yaxawqhj 212 31 monolayers monolayer NNS cord-023584-yaxawqhj 212 32 , , , cord-023584-yaxawqhj 212 33 inhibition inhibition NN cord-023584-yaxawqhj 212 34 of of IN cord-023584-yaxawqhj 212 35 RNA RNA NNP cord-023584-yaxawqhj 212 36 synthesis synthesis NN cord-023584-yaxawqhj 212 37 , , , cord-023584-yaxawqhj 212 38 and and CC cord-023584-yaxawqhj 212 39 inhibition inhibition NN cord-023584-yaxawqhj 212 40 of of IN cord-023584-yaxawqhj 212 41 cell cell NN cord-023584-yaxawqhj 212 42 growth growth NN cord-023584-yaxawqhj 212 43 in in IN cord-023584-yaxawqhj 212 44 newly newly RB cord-023584-yaxawqhj 212 45 seeded seed VBN cord-023584-yaxawqhj 212 46 cultures culture NNS cord-023584-yaxawqhj 212 47 . . . cord-023584-yaxawqhj 213 1 Although although IN cord-023584-yaxawqhj 213 2 this this DT cord-023584-yaxawqhj 213 3 compound compound NN cord-023584-yaxawqhj 213 4 is be VBZ cord-023584-yaxawqhj 213 5 not not RB cord-023584-yaxawqhj 213 6 a a DT cord-023584-yaxawqhj 213 7 specific specific JJ cord-023584-yaxawqhj 213 8 inhibitor inhibitor NN cord-023584-yaxawqhj 213 9 of of IN cord-023584-yaxawqhj 213 10 RNA RNA NNP cord-023584-yaxawqhj 213 11 synthesis synthesis NN cord-023584-yaxawqhj 213 12 , , , cord-023584-yaxawqhj 213 13 the the DT cord-023584-yaxawqhj 213 14 inhibition inhibition NN cord-023584-yaxawqhj 213 15 of of IN cord-023584-yaxawqhj 213 16 RNA RNA NNP cord-023584-yaxawqhj 213 17 synthesis synthesis NN cord-023584-yaxawqhj 213 18 and and CC cord-023584-yaxawqhj 213 19 the the DT cord-023584-yaxawqhj 213 20 production production NN cord-023584-yaxawqhj 213 21 of of IN cord-023584-yaxawqhj 213 22 cytopathic cytopathic JJ cord-023584-yaxawqhj 213 23 effects effect NNS cord-023584-yaxawqhj 213 24 run run VBP cord-023584-yaxawqhj 213 25 close close RB cord-023584-yaxawqhj 213 26 together together RB cord-023584-yaxawqhj 213 27 . . . cord-023584-yaxawqhj 214 1 At at IN cord-023584-yaxawqhj 214 2 concentrations concentration NNS cord-023584-yaxawqhj 214 3 that that WDT cord-023584-yaxawqhj 214 4 indirectly indirectly RB cord-023584-yaxawqhj 214 5 affect affect VBP cord-023584-yaxawqhj 214 6 the the DT cord-023584-yaxawqhj 214 7 nucleic nucleic JJ cord-023584-yaxawqhj 214 8 acid acid NN cord-023584-yaxawqhj 214 9 synthesis synthesis NN cord-023584-yaxawqhj 214 10 , , , cord-023584-yaxawqhj 214 11 sufficient sufficient JJ cord-023584-yaxawqhj 214 12 disturbance disturbance NN cord-023584-yaxawqhj 214 13 is be VBZ cord-023584-yaxawqhj 214 14 caused cause VBN cord-023584-yaxawqhj 214 15 in in IN cord-023584-yaxawqhj 214 16 other other JJ cord-023584-yaxawqhj 214 17 areas area NNS cord-023584-yaxawqhj 214 18 of of IN cord-023584-yaxawqhj 214 19 the the DT cord-023584-yaxawqhj 214 20 cellular cellular JJ cord-023584-yaxawqhj 214 21 metabolism metabolism NN cord-023584-yaxawqhj 214 22 to to TO cord-023584-yaxawqhj 214 23 lead lead VB cord-023584-yaxawqhj 214 24 to to IN cord-023584-yaxawqhj 214 25 a a DT cord-023584-yaxawqhj 214 26 general general JJ cord-023584-yaxawqhj 214 27 cytopathic cytopathic JJ cord-023584-yaxawqhj 214 28 effect effect NN cord-023584-yaxawqhj 214 29 . . . cord-023584-yaxawqhj 215 1 Cell cell NN cord-023584-yaxawqhj 215 2 division division NN cord-023584-yaxawqhj 215 3 is be VBZ cord-023584-yaxawqhj 215 4 affected affect VBN cord-023584-yaxawqhj 215 5 a a DT cord-023584-yaxawqhj 215 6 t t NN cord-023584-yaxawqhj 215 7 lower low JJR cord-023584-yaxawqhj 215 8 concentrations concentration NNS cord-023584-yaxawqhj 215 9 and and CC cord-023584-yaxawqhj 215 10 in in IN cord-023584-yaxawqhj 215 11 this this DT cord-023584-yaxawqhj 215 12 particular particular JJ cord-023584-yaxawqhj 215 13 case case NN cord-023584-yaxawqhj 215 14 , , , cord-023584-yaxawqhj 215 15 inhibitory inhibitory JJ cord-023584-yaxawqhj 215 16 ( ( -LRB- cord-023584-yaxawqhj 215 17 and and CC cord-023584-yaxawqhj 215 18 therefore therefore RB cord-023584-yaxawqhj 215 19 toxic toxic JJ cord-023584-yaxawqhj 215 20 ) ) -RRB- cord-023584-yaxawqhj 215 21 effects effect NNS cord-023584-yaxawqhj 215 22 can can MD cord-023584-yaxawqhj 215 23 be be VB cord-023584-yaxawqhj 215 24 detected detect VBN cord-023584-yaxawqhj 215 25 with with IN cord-023584-yaxawqhj 215 26 concentrations concentration NNS cord-023584-yaxawqhj 215 27 10 10 CD cord-023584-yaxawqhj 215 28 times time NNS cord-023584-yaxawqhj 215 29 lower low JJR cord-023584-yaxawqhj 215 30 than than IN cord-023584-yaxawqhj 215 31 those those DT cord-023584-yaxawqhj 215 32 that that WDT cord-023584-yaxawqhj 215 33 cause cause VBP cord-023584-yaxawqhj 215 34 cell cell NN cord-023584-yaxawqhj 215 35 destruction destruction NN cord-023584-yaxawqhj 215 36 , , , cord-023584-yaxawqhj 215 37 Nevertheless nevertheless RB cord-023584-yaxawqhj 215 38 , , , cord-023584-yaxawqhj 215 39 even even RB cord-023584-yaxawqhj 215 40 with with IN cord-023584-yaxawqhj 215 41 cell cell NN cord-023584-yaxawqhj 215 42 growth growth NN cord-023584-yaxawqhj 215 43 as as IN cord-023584-yaxawqhj 215 44 a a DT cord-023584-yaxawqhj 215 45 measure measure NN cord-023584-yaxawqhj 215 46 of of IN cord-023584-yaxawqhj 215 47 toxicity toxicity NN cord-023584-yaxawqhj 215 48 , , , cord-023584-yaxawqhj 215 49 and and CC cord-023584-yaxawqhj 215 50 effects effect NNS cord-023584-yaxawqhj 215 51 on on IN cord-023584-yaxawqhj 215 52 the the DT cord-023584-yaxawqhj 215 53 cellular cellular JJ cord-023584-yaxawqhj 215 54 growth growth NN cord-023584-yaxawqhj 215 55 rate rate NN cord-023584-yaxawqhj 215 56 ( ( -LRB- cord-023584-yaxawqhj 215 57 & & CC cord-023584-yaxawqhj 215 58 -A -A NNS cord-023584-yaxawqhj 215 59 ) ) -RRB- cord-023584-yaxawqhj 215 60 are be VBP cord-023584-yaxawqhj 215 61 higher high JJR cord-023584-yaxawqhj 215 62 than than IN cord-023584-yaxawqhj 215 63 those those DT cord-023584-yaxawqhj 215 64 that that WDT cord-023584-yaxawqhj 215 65 suppress suppress VBP cord-023584-yaxawqhj 215 66 virus virus NN cord-023584-yaxawqhj 215 67 growth growth NN cord-023584-yaxawqhj 215 68 , , , cord-023584-yaxawqhj 215 69 indicating indicate VBG cord-023584-yaxawqhj 215 70 that that IN cord-023584-yaxawqhj 215 71 ICI ICI NNP cord-023584-yaxawqhj 215 72 65,709 65,709 CD cord-023584-yaxawqhj 215 73 is be VBZ cord-023584-yaxawqhj 215 74 exerting exert VBG cord-023584-yaxawqhj 215 75 a a DT cord-023584-yaxawqhj 215 76 specific specific JJ cord-023584-yaxawqhj 215 77 effect effect NN cord-023584-yaxawqhj 215 78 on on IN cord-023584-yaxawqhj 215 79 virus virus NN cord-023584-yaxawqhj 215 80 growth growth NN cord-023584-yaxawqhj 215 81 . . . cord-023584-yaxawqhj 216 1 ( ( -LRB- cord-023584-yaxawqhj 216 2 50 50 CD cord-023584-yaxawqhj 216 3 % % NN cord-023584-yaxawqhj 216 4 end end NN cord-023584-yaxawqhj 216 5 points point NNS cord-023584-yaxawqhj 216 6 : : : cord-023584-yaxawqhj 216 7 CPE CPE NNP cord-023584-yaxawqhj 216 8 , , , cord-023584-yaxawqhj 216 9 10 10 CD cord-023584-yaxawqhj 216 10 pg pg NN cord-023584-yaxawqhj 216 11 / / SYM cord-023584-yaxawqhj 216 12 ml ml NN cord-023584-yaxawqhj 216 13 ; ; : cord-023584-yaxawqhj 216 14 RNA RNA NNP cord-023584-yaxawqhj 216 15 synthesis synthesis NN cord-023584-yaxawqhj 216 16 , , , cord-023584-yaxawqhj 216 17 10 10 CD cord-023584-yaxawqhj 216 18 pglml pglml NNS cord-023584-yaxawqhj 216 19 ; ; : cord-023584-yaxawqhj 216 20 cell cell NN cord-023584-yaxawqhj 216 21 growth growth NN cord-023584-yaxawqhj 216 22 , , , cord-023584-yaxawqhj 216 23 1.5 1.5 CD cord-023584-yaxawqhj 216 24 pg pg NN cord-023584-yaxawqhj 216 25 / / SYM cord-023584-yaxawqhj 216 26 ml ml NN cord-023584-yaxawqhj 216 27 ; ; : cord-023584-yaxawqhj 216 28 virus virus NN cord-023584-yaxawqhj 216 29 growth growth NN cord-023584-yaxawqhj 216 30 , , , cord-023584-yaxawqhj 216 31 0.05 0.05 CD cord-023584-yaxawqhj 216 32 pg pg NN cord-023584-yaxawqhj 216 33 / / SYM cord-023584-yaxawqhj 216 34 ml ml NN cord-023584-yaxawqhj 216 35 . . . cord-023584-yaxawqhj 216 36 ) ) -RRB- cord-023584-yaxawqhj 217 1 there there EX cord-023584-yaxawqhj 217 2 is be VBZ cord-023584-yaxawqhj 217 3 a a DT cord-023584-yaxawqhj 217 4 clear clear JJ cord-023584-yaxawqhj 217 5 margin margin NN cord-023584-yaxawqhj 217 6 between between IN cord-023584-yaxawqhj 217 7 the the DT cord-023584-yaxawqhj 217 8 toxic toxic JJ cord-023584-yaxawqhj 217 9 and and CC cord-023584-yaxawqhj 217 10 antiviral antiviral JJ cord-023584-yaxawqhj 217 11 effects effect NNS cord-023584-yaxawqhj 217 12 , , , cord-023584-yaxawqhj 217 13 as as IN cord-023584-yaxawqhj 217 14 may may MD cord-023584-yaxawqhj 217 15 be be VB cord-023584-yaxawqhj 217 16 seen see VBN cord-023584-yaxawqhj 217 17 from from IN cord-023584-yaxawqhj 217 18 the the DT cord-023584-yaxawqhj 217 19 virus virus NN cord-023584-yaxawqhj 217 20 yield yield NN cord-023584-yaxawqhj 217 21 curve curve NN cord-023584-yaxawqhj 217 22 . . . cord-023584-yaxawqhj 218 1 Fusidic fusidic JJ cord-023584-yaxawqhj 218 2 acid acid NN cord-023584-yaxawqhj 218 3 , , , cord-023584-yaxawqhj 218 4 which which WDT cord-023584-yaxawqhj 218 5 has have VBZ cord-023584-yaxawqhj 218 6 been be VBN cord-023584-yaxawqhj 218 7 reported report VBN cord-023584-yaxawqhj 218 8 to to TO cord-023584-yaxawqhj 218 9 show show VB cord-023584-yaxawqhj 218 10 specific specific JJ cord-023584-yaxawqhj 218 11 antiviral antiviral JJ cord-023584-yaxawqhj 218 12 activity activity NN cord-023584-yaxawqhj 218 13 in in IN cord-023584-yaxawqhj 218 14 tissue tissue NN cord-023584-yaxawqhj 218 15 culture culture NN cord-023584-yaxawqhj 219 1 ( ( -LRB- cord-023584-yaxawqhj 219 2 Acornley Acornley NNP cord-023584-yaxawqhj 219 3 et et NNP cord-023584-yaxawqhj 219 4 al al NNP cord-023584-yaxawqhj 219 5 . . NNP cord-023584-yaxawqhj 219 6 , , , cord-023584-yaxawqhj 219 7 1967 1967 CD cord-023584-yaxawqhj 219 8 ) ) -RRB- cord-023584-yaxawqhj 219 9 , , , cord-023584-yaxawqhj 219 10 was be VBD cord-023584-yaxawqhj 219 11 also also RB cord-023584-yaxawqhj 219 12 tested test VBN cord-023584-yaxawqhj 219 13 in in IN cord-023584-yaxawqhj 219 14 the the DT cord-023584-yaxawqhj 219 15 same same JJ cord-023584-yaxawqhj 219 16 way way NN cord-023584-yaxawqhj 219 17 ( ( -LRB- cord-023584-yaxawqhj 219 18 Fig fig NN cord-023584-yaxawqhj 219 19 . . NNP cord-023584-yaxawqhj 219 20 2 2 CD cord-023584-yaxawqhj 219 21 ) ) -RRB- cord-023584-yaxawqhj 219 22 . . . cord-023584-yaxawqhj 220 1 In in IN cord-023584-yaxawqhj 220 2 this this DT cord-023584-yaxawqhj 220 3 case case NN cord-023584-yaxawqhj 220 4 , , , cord-023584-yaxawqhj 220 5 the the DT cord-023584-yaxawqhj 220 6 concentration concentration NN cord-023584-yaxawqhj 220 7 causing cause VBG cord-023584-yaxawqhj 220 8 50 50 CD cord-023584-yaxawqhj 220 9 % % NN cord-023584-yaxawqhj 220 10 cytopathic cytopathic JJ cord-023584-yaxawqhj 220 11 effect effect NN cord-023584-yaxawqhj 220 12 after after IN cord-023584-yaxawqhj 220 13 48 48 CD cord-023584-yaxawqhj 220 14 hours hour NNS cord-023584-yaxawqhj 220 15 was be VBD cord-023584-yaxawqhj 220 16 100 100 CD cord-023584-yaxawqhj 220 17 pg pg NN cord-023584-yaxawqhj 220 18 / / SYM cord-023584-yaxawqhj 220 19 ml ml NNS cord-023584-yaxawqhj 220 20 , , , cord-023584-yaxawqhj 220 21 whereas whereas IN cord-023584-yaxawqhj 220 22 virus virus NN cord-023584-yaxawqhj 220 23 yield yield NN cord-023584-yaxawqhj 220 24 was be VBD cord-023584-yaxawqhj 220 25 depressed depressed JJ cord-023584-yaxawqhj 220 26 to to IN cord-023584-yaxawqhj 220 27 50 50 CD cord-023584-yaxawqhj 220 28 % % NN cord-023584-yaxawqhj 220 29 by by IN cord-023584-yaxawqhj 220 30 only only RB cord-023584-yaxawqhj 220 31 3 3 CD cord-023584-yaxawqhj 220 32 pg pg NN cord-023584-yaxawqhj 220 33 / / SYM cord-023584-yaxawqhj 220 34 lml lml NNP cord-023584-yaxawqhj 220 35 , , , cord-023584-yaxawqhj 220 36 giving give VBG cord-023584-yaxawqhj 220 37 an an DT cord-023584-yaxawqhj 220 38 apparent apparent JJ cord-023584-yaxawqhj 220 39 therapeutic therapeutic JJ cord-023584-yaxawqhj 220 40 ratio ratio NN cord-023584-yaxawqhj 220 41 of of IN cord-023584-yaxawqhj 220 42 33 33 CD cord-023584-yaxawqhj 220 43 . . . cord-023584-yaxawqhj 221 1 But but CC cord-023584-yaxawqhj 221 2 when when WRB cord-023584-yaxawqhj 221 3 the the DT cord-023584-yaxawqhj 221 4 effects effect NNS cord-023584-yaxawqhj 221 5 of of IN cord-023584-yaxawqhj 221 6 fusidic fusidic JJ cord-023584-yaxawqhj 221 7 acid acid NN cord-023584-yaxawqhj 221 8 on on IN cord-023584-yaxawqhj 221 9 cellular cellular JJ cord-023584-yaxawqhj 221 10 synthesis synthesis NN cord-023584-yaxawqhj 221 11 were be VBD cord-023584-yaxawqhj 221 12 studied study VBN cord-023584-yaxawqhj 221 13 , , , cord-023584-yaxawqhj 221 14 it -PRON- PRP cord-023584-yaxawqhj 221 15 was be VBD cord-023584-yaxawqhj 221 16 clear clear JJ cord-023584-yaxawqhj 221 17 that that IN cord-023584-yaxawqhj 221 18 cellular cellular JJ cord-023584-yaxawqhj 221 19 RKA RKA NNP cord-023584-yaxawqhj 221 20 synthesis synthesis NN cord-023584-yaxawqhj 221 21 was be VBD cord-023584-yaxawqhj 221 22 drastically drastically RB cord-023584-yaxawqhj 221 23 reduced reduce VBN cord-023584-yaxawqhj 221 24 by by IN cord-023584-yaxawqhj 221 25 3 3 CD cord-023584-yaxawqhj 221 26 pg,!ml pg,!ml NNP cord-023584-yaxawqhj 221 27 . . . cord-023584-yaxawqhj 222 1 Thus thus RB cord-023584-yaxawqhj 222 2 , , , cord-023584-yaxawqhj 222 3 fusidic fusidic JJ cord-023584-yaxawqhj 222 4 acid acid NN cord-023584-yaxawqhj 222 5 probably probably RB cord-023584-yaxawqhj 222 6 reduces reduce VBZ cord-023584-yaxawqhj 222 7 virus virus NN cord-023584-yaxawqhj 222 8 growth growth NN cord-023584-yaxawqhj 222 9 by by IN cord-023584-yaxawqhj 222 10 inhibiting inhibit VBG cord-023584-yaxawqhj 222 11 cellular cellular NN cord-023584-yaxawqhj 222 12 , , , cord-023584-yaxawqhj 222 13 rather rather RB cord-023584-yaxawqhj 222 14 than than IN cord-023584-yaxawqhj 222 15 virus virus NN cord-023584-yaxawqhj 222 16 , , , cord-023584-yaxawqhj 222 17 synthetic synthetic JJ cord-023584-yaxawqhj 222 18 processes process NNS cord-023584-yaxawqhj 222 19 , , , cord-023584-yaxawqhj 222 20 and and CC cord-023584-yaxawqhj 222 21 probably probably RB cord-023584-yaxawqhj 222 22 accounts account VBZ cord-023584-yaxawqhj 222 23 for for IN cord-023584-yaxawqhj 222 24 the the DT cord-023584-yaxawqhj 222 25 fact fact NN cord-023584-yaxawqhj 222 26 that that IN cord-023584-yaxawqhj 222 27 this this DT cord-023584-yaxawqhj 222 28 compound compound NN cord-023584-yaxawqhj 222 29 showed show VBD cord-023584-yaxawqhj 222 30 no no DT cord-023584-yaxawqhj 222 31 clinically clinically RB cord-023584-yaxawqhj 222 32 useful useful JJ cord-023584-yaxawqhj 222 33 effects effect NNS cord-023584-yaxawqhj 222 34 in in IN cord-023584-yaxawqhj 222 35 virus virus NN cord-023584-yaxawqhj 222 36 - - HYPH cord-023584-yaxawqhj 222 37 infected infect VBN cord-023584-yaxawqhj 222 38 volunteers volunteer NNS cord-023584-yaxawqhj 222 39 , , , cord-023584-yaxawqhj 222 40 despite despite IN cord-023584-yaxawqhj 222 41 good good JJ cord-023584-yaxawqhj 222 42 levels level NNS cord-023584-yaxawqhj 222 43 of of IN cord-023584-yaxawqhj 222 44 drug drug NN cord-023584-yaxawqhj 222 45 in in IN cord-023584-yaxawqhj 222 46 blood blood NN cord-023584-yaxawqhj 222 47 and and CC cord-023584-yaxawqhj 222 48 nasal nasal NN cord-023584-yaxawqhj 222 49 secretions secretion NNS cord-023584-yaxawqhj 222 50 ( ( -LRB- cord-023584-yaxawqhj 222 51 Acornley Acornley NNP cord-023584-yaxawqhj 222 52 et et NNP cord-023584-yaxawqhj 222 53 al al NNP cord-023584-yaxawqhj 222 54 . . NNP cord-023584-yaxawqhj 222 55 , , , cord-023584-yaxawqhj 222 56 1967 1967 CD cord-023584-yaxawqhj 222 57 ) ) -RRB- cord-023584-yaxawqhj 222 58 . . . cord-023584-yaxawqhj 223 1 Since since IN cord-023584-yaxawqhj 223 2 the the DT cord-023584-yaxawqhj 223 3 toxic toxic JJ cord-023584-yaxawqhj 223 4 effects effect NNS cord-023584-yaxawqhj 223 5 of of IN cord-023584-yaxawqhj 223 6 compounds compound NNS cord-023584-yaxawqhj 223 7 in in IN cord-023584-yaxawqhj 223 8 vitro vitro FW cord-023584-yaxawqhj 223 9 usually usually RB cord-023584-yaxawqhj 223 10 increase increase VBP cord-023584-yaxawqhj 223 11 with with IN cord-023584-yaxawqhj 223 12 time time NN cord-023584-yaxawqhj 223 13 , , , cord-023584-yaxawqhj 223 14 it -PRON- PRP cord-023584-yaxawqhj 223 15 is be VBZ cord-023584-yaxawqhj 223 16 important important JJ cord-023584-yaxawqhj 223 17 when when WRB cord-023584-yaxawqhj 223 18 comparing compare VBG cord-023584-yaxawqhj 223 19 toxicity toxicity NN cord-023584-yaxawqhj 223 20 and and CC cord-023584-yaxawqhj 223 21 antiviral antiviral JJ cord-023584-yaxawqhj 223 22 activity activity NN cord-023584-yaxawqhj 223 23 , , , cord-023584-yaxawqhj 223 24 to to TO cord-023584-yaxawqhj 223 25 ensure ensure VB cord-023584-yaxawqhj 223 26 that that IN cord-023584-yaxawqhj 223 27 the the DT cord-023584-yaxawqhj 223 28 compound compound NN cord-023584-yaxawqhj 223 29 has have VBZ cord-023584-yaxawqhj 223 30 been be VBN cord-023584-yaxawqhj 223 31 in in IN cord-023584-yaxawqhj 223 32 contact contact NN cord-023584-yaxawqhj 223 33 xvith xvith NN cord-023584-yaxawqhj 223 34 cells cell NNS cord-023584-yaxawqhj 223 35 for for IN cord-023584-yaxawqhj 223 36 the the DT cord-023584-yaxawqhj 223 37 same same JJ cord-023584-yaxawqhj 223 38 length length NN cord-023584-yaxawqhj 223 39 of of IN cord-023584-yaxawqhj 223 40 time time NN cord-023584-yaxawqhj 223 41 in in IN cord-023584-yaxawqhj 223 42 each each DT cord-023584-yaxawqhj 223 43 case case NN cord-023584-yaxawqhj 223 44 . . . cord-023584-yaxawqhj 224 1 In in IN cord-023584-yaxawqhj 224 2 the the DT cord-023584-yaxawqhj 224 3 above above JJ cord-023584-yaxawqhj 224 4 experiment experiment NN cord-023584-yaxawqhj 224 5 , , , cord-023584-yaxawqhj 224 6 the the DT cord-023584-yaxawqhj 224 7 cytopathic cytopathic JJ cord-023584-yaxawqhj 224 8 effect effect NN cord-023584-yaxawqhj 224 9 , , , cord-023584-yaxawqhj 224 10 RNA RNA NNP cord-023584-yaxawqhj 224 11 synthesis synthesis NN cord-023584-yaxawqhj 224 12 , , , cord-023584-yaxawqhj 224 13 cell cell NN cord-023584-yaxawqhj 224 14 growth growth NN cord-023584-yaxawqhj 224 15 , , , cord-023584-yaxawqhj 224 16 and and CC cord-023584-yaxawqhj 224 17 virus virus NN cord-023584-yaxawqhj 224 18 inhibition inhibition NN cord-023584-yaxawqhj 224 19 were be VBD cord-023584-yaxawqhj 224 20 all all DT cord-023584-yaxawqhj 224 21 measured measure VBN cord-023584-yaxawqhj 224 22 in in IN cord-023584-yaxawqhj 224 23 cells cell NNS cord-023584-yaxawqhj 224 24 that that WDT cord-023584-yaxawqhj 224 25 had have VBD cord-023584-yaxawqhj 224 26 been be VBN cord-023584-yaxawqhj 224 27 exposed expose VBN cord-023584-yaxawqhj 224 28 to to IN cord-023584-yaxawqhj 224 29 the the DT cord-023584-yaxawqhj 224 30 compound compound NN cord-023584-yaxawqhj 224 31 for for IN cord-023584-yaxawqhj 224 32 48 48 CD cord-023584-yaxawqhj 224 33 hours hour NNS cord-023584-yaxawqhj 224 34 . . . cord-023584-yaxawqhj 224 35 _SP cord-023584-yaxawqhj 225 1 When when WRB cord-023584-yaxawqhj 225 2 a a DT cord-023584-yaxawqhj 225 3 virus virus NN cord-023584-yaxawqhj 225 4 disease disease NN cord-023584-yaxawqhj 225 5 is be VBZ cord-023584-yaxawqhj 225 6 limited limit VBN cord-023584-yaxawqhj 225 7 to to IN cord-023584-yaxawqhj 225 8 a a DT cord-023584-yaxawqhj 225 9 particular particular JJ cord-023584-yaxawqhj 225 10 target target NN cord-023584-yaxawqhj 225 11 organ organ NN cord-023584-yaxawqhj 225 12 , , , cord-023584-yaxawqhj 225 13 such such JJ cord-023584-yaxawqhj 225 14 as as IN cord-023584-yaxawqhj 225 15 the the DT cord-023584-yaxawqhj 225 16 respiratory respiratory JJ cord-023584-yaxawqhj 225 17 tract tract NN cord-023584-yaxawqhj 225 18 , , , cord-023584-yaxawqhj 225 19 it -PRON- PRP cord-023584-yaxawqhj 225 20 is be VBZ cord-023584-yaxawqhj 225 21 of of IN cord-023584-yaxawqhj 225 22 great great JJ cord-023584-yaxawqhj 225 23 value value NN cord-023584-yaxawqhj 225 24 to to TO cord-023584-yaxawqhj 225 25 be be VB cord-023584-yaxawqhj 225 26 able able JJ cord-023584-yaxawqhj 225 27 to to TO cord-023584-yaxawqhj 225 28 culture culture VB cord-023584-yaxawqhj 225 29 a a DT cord-023584-yaxawqhj 225 30 portion portion NN cord-023584-yaxawqhj 225 31 of of IN cord-023584-yaxawqhj 225 32 the the DT cord-023584-yaxawqhj 225 33 organ organ NN cord-023584-yaxawqhj 225 34 for for IN cord-023584-yaxawqhj 225 35 in in FW cord-023584-yaxawqhj 225 36 vitro vitro FW cord-023584-yaxawqhj 225 37 studies study NNS cord-023584-yaxawqhj 225 38 . . . cord-023584-yaxawqhj 226 1 The the DT cord-023584-yaxawqhj 226 2 culture culture NN cord-023584-yaxawqhj 226 3 of of IN cord-023584-yaxawqhj 226 4 portibns portibns NN cord-023584-yaxawqhj 226 5 of of IN cord-023584-yaxawqhj 226 6 trachea trachea NN cord-023584-yaxawqhj 226 7 has have VBZ cord-023584-yaxawqhj 226 8 been be VBN cord-023584-yaxawqhj 226 9 extensively extensively RB cord-023584-yaxawqhj 226 10 used use VBN cord-023584-yaxawqhj 226 11 to to TO cord-023584-yaxawqhj 226 12 study study VB cord-023584-yaxawqhj 226 13 the the DT cord-023584-yaxawqhj 226 14 growth growth NN cord-023584-yaxawqhj 226 15 of of IN cord-023584-yaxawqhj 226 16 respiratory respiratory JJ cord-023584-yaxawqhj 226 17 viruses virus NNS cord-023584-yaxawqhj 226 18 ( ( -LRB- cord-023584-yaxawqhj 226 19 Hoorn Hoorn NNP cord-023584-yaxawqhj 226 20 and and CC cord-023584-yaxawqhj 226 21 Tyrell Tyrell NNP cord-023584-yaxawqhj 226 22 , , , cord-023584-yaxawqhj 226 23 1965 1965 CD cord-023584-yaxawqhj 226 24 , , , cord-023584-yaxawqhj 226 25 1966 1966 CD cord-023584-yaxawqhj 226 26 ; ; : cord-023584-yaxawqhj 226 27 McIntosh McIntosh NNP cord-023584-yaxawqhj 226 28 et et NNP cord-023584-yaxawqhj 226 29 al al NNP cord-023584-yaxawqhj 226 30 . . NNP cord-023584-yaxawqhj 226 31 , , , cord-023584-yaxawqhj 226 32 1967 1967 CD cord-023584-yaxawqhj 226 33 ; ; : cord-023584-yaxawqhj 226 34 Craighead Craighead NNP cord-023584-yaxawqhj 226 35 and and CC cord-023584-yaxawqhj 226 36 Brennan Brennan NNP cord-023584-yaxawqhj 226 37 , , , cord-023584-yaxawqhj 226 38 1968 1968 CD cord-023584-yaxawqhj 226 39 ; ; : cord-023584-yaxawqhj 226 40 Herbst Herbst NNP cord-023584-yaxawqhj 226 41 - - HYPH cord-023584-yaxawqhj 226 42 Laier Laier NNP cord-023584-yaxawqhj 226 43 , , , cord-023584-yaxawqhj 226 44 1970 1970 CD cord-023584-yaxawqhj 226 45 ) ) -RRB- cord-023584-yaxawqhj 226 46 , , , cord-023584-yaxawqhj 226 47 and and CC cord-023584-yaxawqhj 226 48 recently recently RB cord-023584-yaxawqhj 226 49 organ organ NN cord-023584-yaxawqhj 226 50 cultures culture NNS cord-023584-yaxawqhj 226 51 of of IN cord-023584-yaxawqhj 226 52 human human JJ cord-023584-yaxawqhj 226 53 embryonic embryonic JJ cord-023584-yaxawqhj 226 54 gut gut NN cord-023584-yaxawqhj 226 55 have have VBP cord-023584-yaxawqhj 226 56 been be VBN cord-023584-yaxawqhj 226 57 used use VBN cord-023584-yaxawqhj 226 58 to to TO cord-023584-yaxawqhj 226 59 study study VB cord-023584-yaxawqhj 226 60 the the DT cord-023584-yaxawqhj 226 61 agents agent NNS cord-023584-yaxawqhj 226 62 of of IN cord-023584-yaxawqhj 226 63 human human JJ cord-023584-yaxawqhj 226 64 " " `` cord-023584-yaxawqhj 226 65 virus virus NN cord-023584-yaxawqhj 226 66 " " '' cord-023584-yaxawqhj 226 67 gastroenteritis gastroenteritis NN cord-023584-yaxawqhj 226 68 ( ( -LRB- cord-023584-yaxawqhj 226 69 D d NN cord-023584-yaxawqhj 226 70 o o NN cord-023584-yaxawqhj 226 71 h h NN cord-023584-yaxawqhj 226 72 et et FW cord-023584-yaxawqhj 226 73 al al NNP cord-023584-yaxawqhj 226 74 . . NNP cord-023584-yaxawqhj 226 75 , , , cord-023584-yaxawqhj 226 76 1970 1970 CD cord-023584-yaxawqhj 226 77 ) ) -RRB- cord-023584-yaxawqhj 226 78 . . . cord-023584-yaxawqhj 227 1 The the DT cord-023584-yaxawqhj 227 2 technique technique NN cord-023584-yaxawqhj 227 3 could could MD cord-023584-yaxawqhj 227 4 presumably presumably RB cord-023584-yaxawqhj 227 5 be be VB cord-023584-yaxawqhj 227 6 extended extend VBN cord-023584-yaxawqhj 227 7 to to IN cord-023584-yaxawqhj 227 8 the the DT cord-023584-yaxawqhj 227 9 study study NN cord-023584-yaxawqhj 227 10 of of IN cord-023584-yaxawqhj 227 11 viruses virus NNS cord-023584-yaxawqhj 227 12 , , , cord-023584-yaxawqhj 227 13 such such JJ cord-023584-yaxawqhj 227 14 as as IN cord-023584-yaxawqhj 227 15 polio polio NN cord-023584-yaxawqhj 227 16 , , , cord-023584-yaxawqhj 227 17 rabies rabie NNS cord-023584-yaxawqhj 227 18 , , , cord-023584-yaxawqhj 227 19 smallpox smallpox NN cord-023584-yaxawqhj 227 20 , , , cord-023584-yaxawqhj 227 21 and and CC cord-023584-yaxawqhj 227 22 herpes herpe NNS cord-023584-yaxawqhj 227 23 , , , cord-023584-yaxawqhj 227 24 which which WDT cord-023584-yaxawqhj 227 25 localize localize VBP cord-023584-yaxawqhj 227 26 in in IN cord-023584-yaxawqhj 227 27 specific specific JJ cord-023584-yaxawqhj 227 28 organs organ NNS cord-023584-yaxawqhj 227 29 of of IN cord-023584-yaxawqhj 227 30 infected infected JJ cord-023584-yaxawqhj 227 31 individuals individual NNS cord-023584-yaxawqhj 227 32 . . . cord-023584-yaxawqhj 228 1 We -PRON- PRP cord-023584-yaxawqhj 228 2 have have VBP cord-023584-yaxawqhj 228 3 found find VBN cord-023584-yaxawqhj 228 4 the the DT cord-023584-yaxawqhj 228 5 use use NN cord-023584-yaxawqhj 228 6 of of IN cord-023584-yaxawqhj 228 7 human human JJ cord-023584-yaxawqhj 228 8 embryo embryo NN cord-023584-yaxawqhj 228 9 and and CC cord-023584-yaxawqhj 228 10 animal animal NN cord-023584-yaxawqhj 228 11 tracheal tracheal NN cord-023584-yaxawqhj 228 12 pieces piece NNS cord-023584-yaxawqhj 228 13 of of IN cord-023584-yaxawqhj 228 14 value value NN cord-023584-yaxawqhj 228 15 in in IN cord-023584-yaxawqhj 228 16 studying study VBG cord-023584-yaxawqhj 228 17 the the DT cord-023584-yaxawqhj 228 18 toxicity toxicity NN cord-023584-yaxawqhj 228 19 and and CC cord-023584-yaxawqhj 228 20 the the DT cord-023584-yaxawqhj 228 21 antiviral antiviral JJ cord-023584-yaxawqhj 228 22 activity activity NN cord-023584-yaxawqhj 228 23 of of IN cord-023584-yaxawqhj 228 24 leads lead NNS cord-023584-yaxawqhj 228 25 produced produce VBN cord-023584-yaxawqhj 228 26 by by IN cord-023584-yaxawqhj 228 27 tissue tissue NN cord-023584-yaxawqhj 228 28 culture culture NN cord-023584-yaxawqhj 228 29 screening screening NN cord-023584-yaxawqhj 228 30 programs program NNS cord-023584-yaxawqhj 228 31 . . . cord-023584-yaxawqhj 229 1 Our -PRON- PRP$ cord-023584-yaxawqhj 229 2 technique technique NN cord-023584-yaxawqhj 229 3 is be VBZ cord-023584-yaxawqhj 229 4 to to TO cord-023584-yaxawqhj 229 5 excise excise VB cord-023584-yaxawqhj 229 6 a a DT cord-023584-yaxawqhj 229 7 trachea trachea NN cord-023584-yaxawqhj 229 8 and and CC cord-023584-yaxawqhj 229 9 cut cut VBD cord-023584-yaxawqhj 229 10 it -PRON- PRP cord-023584-yaxawqhj 229 11 transversely transversely RB cord-023584-yaxawqhj 229 12 into into IN cord-023584-yaxawqhj 229 13 rings ring NNS cord-023584-yaxawqhj 229 14 1 1 CD cord-023584-yaxawqhj 229 15 - - SYM cord-023584-yaxawqhj 229 16 2 2 CD cord-023584-yaxawqhj 229 17 mm mm NN cord-023584-yaxawqhj 229 18 thick thick JJ cord-023584-yaxawqhj 229 19 . . . cord-023584-yaxawqhj 230 1 These these DT cord-023584-yaxawqhj 230 2 are be VBP cord-023584-yaxawqhj 230 3 placed place VBN cord-023584-yaxawqhj 230 4 in in IN cord-023584-yaxawqhj 230 5 3 3 CD cord-023584-yaxawqhj 230 6 X x NN cord-023584-yaxawqhj 230 7 3 3 CD cord-023584-yaxawqhj 230 8 in in RP cord-023584-yaxawqhj 230 9 . . . cord-023584-yaxawqhj 231 1 tubes tube NNS cord-023584-yaxawqhj 231 2 with with IN cord-023584-yaxawqhj 231 3 1 1 CD cord-023584-yaxawqhj 231 4 ml ml NNS cord-023584-yaxawqhj 231 5 of of IN cord-023584-yaxawqhj 231 6 Eagle Eagle NNP cord-023584-yaxawqhj 231 7 's 's POS cord-023584-yaxawqhj 231 8 medium medium NN cord-023584-yaxawqhj 231 9 and and CC cord-023584-yaxawqhj 231 10 rolled roll VBD cord-023584-yaxawqhj 231 11 exactly exactly RB cord-023584-yaxawqhj 231 12 as as IN cord-023584-yaxawqhj 231 13 conventional conventional JJ cord-023584-yaxawqhj 231 14 tissue tissue NN cord-023584-yaxawqhj 231 15 cultures culture NNS cord-023584-yaxawqhj 231 16 . . . cord-023584-yaxawqhj 232 1 With with IN cord-023584-yaxawqhj 232 2 a a DT cord-023584-yaxawqhj 232 3 low low JJ cord-023584-yaxawqhj 232 4 - - HYPH cord-023584-yaxawqhj 232 5 power power NN cord-023584-yaxawqhj 232 6 microscope microscope NN cord-023584-yaxawqhj 232 7 the the DT cord-023584-yaxawqhj 232 8 ciliary ciliary NN cord-023584-yaxawqhj 232 9 activity activity NN cord-023584-yaxawqhj 232 10 of of IN cord-023584-yaxawqhj 232 11 the the DT cord-023584-yaxawqhj 232 12 respiratory respiratory JJ cord-023584-yaxawqhj 232 13 epithelium epithelium NN cord-023584-yaxawqhj 232 14 is be VBZ cord-023584-yaxawqhj 232 15 assessed assess VBN cord-023584-yaxawqhj 232 16 on on IN cord-023584-yaxawqhj 232 17 an an DT cord-023584-yaxawqhj 232 18 arbitrary arbitrary JJ cord-023584-yaxawqhj 232 19 scale scale NN cord-023584-yaxawqhj 232 20 of of IN cord-023584-yaxawqhj 232 21 0 0 CD cord-023584-yaxawqhj 232 22 to to IN cord-023584-yaxawqhj 232 23 4 4 CD cord-023584-yaxawqhj 232 24 . . . cord-023584-yaxawqhj 233 1 In in IN cord-023584-yaxawqhj 233 2 the the DT cord-023584-yaxawqhj 233 3 presence presence NN cord-023584-yaxawqhj 233 4 of of IN cord-023584-yaxawqhj 233 5 a a DT cord-023584-yaxawqhj 233 6 test test NN cord-023584-yaxawqhj 233 7 compound compound NN cord-023584-yaxawqhj 233 8 , , , cord-023584-yaxawqhj 233 9 the the DT cord-023584-yaxawqhj 233 10 reduction reduction NN cord-023584-yaxawqhj 233 11 of of IN cord-023584-yaxawqhj 233 12 ciliary ciliary NN cord-023584-yaxawqhj 233 13 action action NN cord-023584-yaxawqhj 233 14 is be VBZ cord-023584-yaxawqhj 233 15 a a DT cord-023584-yaxawqhj 233 16 highly highly RB cord-023584-yaxawqhj 233 17 sensitive sensitive JJ cord-023584-yaxawqhj 233 18 measure measure NN cord-023584-yaxawqhj 233 19 of of IN cord-023584-yaxawqhj 233 20 compound compound NN cord-023584-yaxawqhj 233 21 toxicity toxicity NN cord-023584-yaxawqhj 233 22 , , , cord-023584-yaxawqhj 233 23 and and CC cord-023584-yaxawqhj 233 24 it -PRON- PRP cord-023584-yaxawqhj 233 25 is be VBZ cord-023584-yaxawqhj 233 26 easy easy JJ cord-023584-yaxawqhj 233 27 to to TO cord-023584-yaxawqhj 233 28 determine determine VB cord-023584-yaxawqhj 233 29 the the DT cord-023584-yaxawqhj 233 30 concentration concentration NN cord-023584-yaxawqhj 233 31 at at IN cord-023584-yaxawqhj 233 32 which which WDT cord-023584-yaxawqhj 233 33 full full JJ cord-023584-yaxawqhj 233 34 ciliary ciliary NN cord-023584-yaxawqhj 233 35 activity activity NN cord-023584-yaxawqhj 233 36 can can MD cord-023584-yaxawqhj 233 37 be be VB cord-023584-yaxawqhj 233 38 maintained maintain VBN cord-023584-yaxawqhj 233 39 ( ( -LRB- cord-023584-yaxawqhj 233 40 Fig Fig NNP cord-023584-yaxawqhj 233 41 . . . cord-023584-yaxawqhj 233 42 3 3 CD cord-023584-yaxawqhj 233 43 ) ) -RRB- cord-023584-yaxawqhj 233 44 . . . cord-023584-yaxawqhj 234 1 At at IN cord-023584-yaxawqhj 234 2 lower low JJR cord-023584-yaxawqhj 234 3 concentrations concentration NNS cord-023584-yaxawqhj 234 4 the the DT cord-023584-yaxawqhj 234 5 effects effect NNS cord-023584-yaxawqhj 234 6 on on IN cord-023584-yaxawqhj 234 7 virus virus NN cord-023584-yaxawqhj 234 8 growth growth NN cord-023584-yaxawqhj 234 9 may may MD cord-023584-yaxawqhj 234 10 be be VB cord-023584-yaxawqhj 234 11 measured measure VBN cord-023584-yaxawqhj 234 12 by by IN cord-023584-yaxawqhj 234 13 harvesting harvest VBG cord-023584-yaxawqhj 234 14 the the DT cord-023584-yaxawqhj 234 15 culture culture NN cord-023584-yaxawqhj 234 16 fluid fluid NN cord-023584-yaxawqhj 234 17 at at IN cord-023584-yaxawqhj 234 18 intervals interval NNS cord-023584-yaxawqhj 234 19 and and CC cord-023584-yaxawqhj 234 20 titrating titrate VBG cord-023584-yaxawqhj 234 21 for for IN cord-023584-yaxawqhj 234 22 infectious infectious JJ cord-023584-yaxawqhj 234 23 virus virus NN cord-023584-yaxawqhj 234 24 . . . cord-023584-yaxawqhj 235 1 By by IN cord-023584-yaxawqhj 235 2 using use VBG cord-023584-yaxawqhj 235 3 this this DT cord-023584-yaxawqhj 235 4 technique technique NN cord-023584-yaxawqhj 235 5 , , , cord-023584-yaxawqhj 235 6 we -PRON- PRP cord-023584-yaxawqhj 235 7 have have VBP cord-023584-yaxawqhj 235 8 found find VBN cord-023584-yaxawqhj 235 9 that that IN cord-023584-yaxawqhj 235 10 almost almost RB cord-023584-yaxawqhj 235 11 70 70 CD cord-023584-yaxawqhj 235 12 % % NN cord-023584-yaxawqhj 235 13 of of IN cord-023584-yaxawqhj 235 14 the the DT cord-023584-yaxawqhj 235 15 so so RB cord-023584-yaxawqhj 235 16 - - HYPH cord-023584-yaxawqhj 235 17 called call VBN cord-023584-yaxawqhj 235 18 active active JJ cord-023584-yaxawqhj 235 19 compounds compound NNS cord-023584-yaxawqhj 235 20 produced produce VBN cord-023584-yaxawqhj 235 21 by by IN cord-023584-yaxawqhj 235 22 a a DT cord-023584-yaxawqhj 235 23 tissue tissue NN cord-023584-yaxawqhj 235 24 culture culture NN cord-023584-yaxawqhj 235 25 screen screen NN cord-023584-yaxawqhj 235 26 against against IN cord-023584-yaxawqhj 235 27 influenza influenza NN cord-023584-yaxawqhj 235 28 A A NNP cord-023584-yaxawqhj 235 29 appear appear VBP cord-023584-yaxawqhj 235 30 negative negative JJ cord-023584-yaxawqhj 235 31 when when WRB cord-023584-yaxawqhj 235 32 tested test VBN cord-023584-yaxawqhj 235 33 in in IN cord-023584-yaxawqhj 235 34 ferret ferret JJ cord-023584-yaxawqhj 235 35 tracheal tracheal NN cord-023584-yaxawqhj 235 36 cultures culture NNS cord-023584-yaxawqhj 235 37 . . . cord-023584-yaxawqhj 236 1 In in IN cord-023584-yaxawqhj 236 2 almost almost RB cord-023584-yaxawqhj 236 3 all all DT cord-023584-yaxawqhj 236 4 cases case NNS cord-023584-yaxawqhj 236 5 , , , cord-023584-yaxawqhj 236 6 compounds compound NNS cord-023584-yaxawqhj 236 7 were be VBD cord-023584-yaxawqhj 236 8 toxic toxic JJ cord-023584-yaxawqhj 236 9 at at IN cord-023584-yaxawqhj 236 10 lower low JJR cord-023584-yaxawqhj 236 11 concentrations concentration NNS cord-023584-yaxawqhj 236 12 in in IN cord-023584-yaxawqhj 236 13 tracheal tracheal JJ cord-023584-yaxawqhj 236 14 cultures culture NNS cord-023584-yaxawqhj 236 15 than than IN cord-023584-yaxawqhj 236 16 in in IN cord-023584-yaxawqhj 236 17 conventional conventional JJ cord-023584-yaxawqhj 236 18 tissue tissue NN cord-023584-yaxawqhj 236 19 culture culture NN cord-023584-yaxawqhj 236 20 monolayers monolayer NNS cord-023584-yaxawqhj 236 21 , , , cord-023584-yaxawqhj 236 22 as as IN cord-023584-yaxawqhj 236 23 judged judge VBN cord-023584-yaxawqhj 236 24 by by IN cord-023584-yaxawqhj 236 25 a a DT cord-023584-yaxawqhj 236 26 cessation cessation NN cord-023584-yaxawqhj 236 27 of of IN cord-023584-yaxawqhj 236 28 ciliary ciliary NN cord-023584-yaxawqhj 236 29 activity activity NN cord-023584-yaxawqhj 236 30 . . . cord-023584-yaxawqhj 237 1 In in IN cord-023584-yaxawqhj 237 2 a a DT cord-023584-yaxawqhj 237 3 proportion proportion NN cord-023584-yaxawqhj 237 4 of of IN cord-023584-yaxawqhj 237 5 these these DT cord-023584-yaxawqhj 237 6 compounds compound NNS cord-023584-yaxawqhj 237 7 , , , cord-023584-yaxawqhj 237 8 some some DT cord-023584-yaxawqhj 237 9 data datum NNS cord-023584-yaxawqhj 237 10 concerning concern VBG cord-023584-yaxawqhj 237 11 their -PRON- PRP$ cord-023584-yaxawqhj 237 12 biochemical biochemical JJ cord-023584-yaxawqhj 237 13 action action NN cord-023584-yaxawqhj 237 14 were be VBD cord-023584-yaxawqhj 237 15 available available JJ cord-023584-yaxawqhj 237 16 , , , cord-023584-yaxawqhj 237 17 and and CC cord-023584-yaxawqhj 237 18 in in IN cord-023584-yaxawqhj 237 19 most most JJS cord-023584-yaxawqhj 237 20 cases case NNS cord-023584-yaxawqhj 237 21 these these DT cord-023584-yaxawqhj 237 22 drugs drug NNS cord-023584-yaxawqhj 237 23 were be VBD cord-023584-yaxawqhj 237 24 uncouplers uncoupler NNS cord-023584-yaxawqhj 237 25 of of IN cord-023584-yaxawqhj 237 26 oxidative oxidative JJ cord-023584-yaxawqhj 237 27 phosphorylation phosphorylation NN cord-023584-yaxawqhj 237 28 , , , cord-023584-yaxawqhj 237 29 nucleic nucleic JJ cord-023584-yaxawqhj 237 30 acid acid NN cord-023584-yaxawqhj 237 31 inhibitors inhibitor NNS cord-023584-yaxawqhj 237 32 , , , cord-023584-yaxawqhj 237 33 or or CC cord-023584-yaxawqhj 237 34 general general JJ cord-023584-yaxawqhj 237 35 antimetabolites antimetabolite NNS cord-023584-yaxawqhj 237 36 . . . cord-023584-yaxawqhj 238 1 The the DT cord-023584-yaxawqhj 238 2 inhibition inhibition NN cord-023584-yaxawqhj 238 3 of of IN cord-023584-yaxawqhj 238 4 ciliary ciliary JJ cord-023584-yaxawqhj 238 5 action action NN cord-023584-yaxawqhj 238 6 in in IN cord-023584-yaxawqhj 238 7 tracheal tracheal JJ cord-023584-yaxawqhj 238 8 cultures culture NNS cord-023584-yaxawqhj 238 9 is be VBZ cord-023584-yaxawqhj 238 10 , , , cord-023584-yaxawqhj 238 11 therefore therefore RB cord-023584-yaxawqhj 238 12 ; ; : cord-023584-yaxawqhj 238 13 a a DT cord-023584-yaxawqhj 238 14 much much RB cord-023584-yaxawqhj 238 15 more more RBR cord-023584-yaxawqhj 238 16 sensitive sensitive JJ cord-023584-yaxawqhj 238 17 index index NN cord-023584-yaxawqhj 238 18 of of IN cord-023584-yaxawqhj 238 19 toxic toxic JJ cord-023584-yaxawqhj 238 20 effects effect NNS cord-023584-yaxawqhj 238 21 than than IN cord-023584-yaxawqhj 238 22 morphological morphological JJ cord-023584-yaxawqhj 238 23 changes change NNS cord-023584-yaxawqhj 238 24 in in IN cord-023584-yaxawqhj 238 25 monolayers monolayer NNS cord-023584-yaxawqhj 238 26 . . . cord-023584-yaxawqhj 239 1 In in IN cord-023584-yaxawqhj 239 2 Fig Fig NNP cord-023584-yaxawqhj 239 3 . . . cord-023584-yaxawqhj 240 1 3 3 LS cord-023584-yaxawqhj 240 2 , , , cord-023584-yaxawqhj 240 3 the the DT cord-023584-yaxawqhj 240 4 50 50 CD cord-023584-yaxawqhj 240 5 % % NN cord-023584-yaxawqhj 240 6 cilia cilia NN cord-023584-yaxawqhj 240 7 - - HYPH cord-023584-yaxawqhj 240 8 inhibitory inhibitory JJ cord-023584-yaxawqhj 240 9 concentration concentration NN cord-023584-yaxawqhj 240 10 of of IN cord-023584-yaxawqhj 240 11 ICI ICI NNP cord-023584-yaxawqhj 240 12 65,709 65,709 CD cord-023584-yaxawqhj 240 13 is be VBZ cord-023584-yaxawqhj 240 14 2.0 2.0 CD cord-023584-yaxawqhj 240 15 pg/ pg/ NN cord-023584-yaxawqhj 240 16 ml ml NN cord-023584-yaxawqhj 240 17 . . . cord-023584-yaxawqhj 241 1 This this DT cord-023584-yaxawqhj 241 2 effect effect NN cord-023584-yaxawqhj 241 3 is be VBZ cord-023584-yaxawqhj 241 4 detected detect VBN cord-023584-yaxawqhj 241 5 at at IN cord-023584-yaxawqhj 241 6 a a DT cord-023584-yaxawqhj 241 7 concentration concentration NN cord-023584-yaxawqhj 241 8 5 5 CD cord-023584-yaxawqhj 241 9 times time NNS cord-023584-yaxawqhj 241 10 lower low JJR cord-023584-yaxawqhj 241 11 than than IN cord-023584-yaxawqhj 241 12 is be VBZ cord-023584-yaxawqhj 241 13 necessary necessary JJ cord-023584-yaxawqhj 241 14 to to TO cord-023584-yaxawqhj 241 15 cause cause VB cord-023584-yaxawqhj 241 16 morphological morphological JJ cord-023584-yaxawqhj 241 17 changes change NNS cord-023584-yaxawqhj 241 18 in in IN cord-023584-yaxawqhj 241 19 conventional conventional JJ cord-023584-yaxawqhj 241 20 tissue tissue NN cord-023584-yaxawqhj 241 21 culture culture NN cord-023584-yaxawqhj 241 22 cells cell NNS cord-023584-yaxawqhj 241 23 ( ( -LRB- cord-023584-yaxawqhj 241 24 Fig Fig NNP cord-023584-yaxawqhj 241 25 . . . cord-023584-yaxawqhj 241 26 l l NNP cord-023584-yaxawqhj 241 27 ) ) -RRB- cord-023584-yaxawqhj 241 28 , , , cord-023584-yaxawqhj 241 29 presumably presumably RB cord-023584-yaxawqhj 241 30 because because IN cord-023584-yaxawqhj 241 31 the the DT cord-023584-yaxawqhj 241 32 metabolic metabolic JJ cord-023584-yaxawqhj 241 33 patterns pattern NNS cord-023584-yaxawqhj 241 34 of of IN cord-023584-yaxawqhj 241 35 the the DT cord-023584-yaxawqhj 241 36 ciliated ciliated JJ cord-023584-yaxawqhj 241 37 cells cell NNS cord-023584-yaxawqhj 241 38 are be VBP cord-023584-yaxawqhj 241 39 more more RBR cord-023584-yaxawqhj 241 40 complex complex JJ cord-023584-yaxawqhj 241 41 than than IN cord-023584-yaxawqhj 241 42 those those DT cord-023584-yaxawqhj 241 43 of of IN cord-023584-yaxawqhj 241 44 static static JJ cord-023584-yaxawqhj 241 45 cells cell NNS cord-023584-yaxawqhj 241 46 in in IN cord-023584-yaxawqhj 241 47 culture culture NN cord-023584-yaxawqhj 241 48 and and CC cord-023584-yaxawqhj 241 49 are be VBP cord-023584-yaxawqhj 241 50 , , , cord-023584-yaxawqhj 241 51 therefore therefore RB cord-023584-yaxawqhj 241 52 , , , cord-023584-yaxawqhj 241 53 more more RBR cord-023584-yaxawqhj 241 54 readily readily RB cord-023584-yaxawqhj 241 55 disturbed disturb VBN cord-023584-yaxawqhj 241 56 . . . cord-023584-yaxawqhj 242 1 In in IN cord-023584-yaxawqhj 242 2 general general JJ cord-023584-yaxawqhj 242 3 , , , cord-023584-yaxawqhj 242 4 the the DT cord-023584-yaxawqhj 242 5 concentrations concentration NNS cord-023584-yaxawqhj 242 6 of of IN cord-023584-yaxawqhj 242 7 compounds compound NNS cord-023584-yaxawqhj 242 8 that that WDT cord-023584-yaxawqhj 242 9 suppress suppress VBP cord-023584-yaxawqhj 242 10 ciliary ciliary NN cord-023584-yaxawqhj 242 11 activity activity NN cord-023584-yaxawqhj 242 12 arc arc NN cord-023584-yaxawqhj 242 13 comparable comparable JJ cord-023584-yaxawqhj 242 14 to to IN cord-023584-yaxawqhj 242 15 those those DT cord-023584-yaxawqhj 242 16 that that WDT cord-023584-yaxawqhj 242 17 prevent prevent VBP cord-023584-yaxawqhj 242 18 cell cell NN cord-023584-yaxawqhj 242 19 growth growth NN cord-023584-yaxawqhj 242 20 , , , cord-023584-yaxawqhj 242 21 except except IN cord-023584-yaxawqhj 242 22 in in IN cord-023584-yaxawqhj 242 23 the the DT cord-023584-yaxawqhj 242 24 case case NN cord-023584-yaxawqhj 242 25 of of IN cord-023584-yaxawqhj 242 26 specific specific JJ cord-023584-yaxawqhj 242 27 inhibitors inhibitor NNS cord-023584-yaxawqhj 242 28 of of IN cord-023584-yaxawqhj 242 29 DSA DSA NNP cord-023584-yaxawqhj 242 30 synthesis synthesis NN cord-023584-yaxawqhj 242 31 for for IN cord-023584-yaxawqhj 242 32 which which WDT cord-023584-yaxawqhj 242 33 cell cell NN cord-023584-yaxawqhj 242 34 division division NN cord-023584-yaxawqhj 242 35 and and CC cord-023584-yaxawqhj 242 36 growth growth NN cord-023584-yaxawqhj 242 37 are be VBP cord-023584-yaxawqhj 242 38 usually usually RB cord-023584-yaxawqhj 242 39 more more RBR cord-023584-yaxawqhj 242 40 sensitive sensitive JJ cord-023584-yaxawqhj 242 41 than than IN cord-023584-yaxawqhj 242 42 ciliary ciliary JJ cord-023584-yaxawqhj 242 43 activity activity NN cord-023584-yaxawqhj 242 44 . . . cord-023584-yaxawqhj 243 1 Any any DT cord-023584-yaxawqhj 243 2 conventional conventional JJ cord-023584-yaxawqhj 243 3 technique technique NN cord-023584-yaxawqhj 243 4 may may MD cord-023584-yaxawqhj 243 5 be be VB cord-023584-yaxawqhj 243 6 used use VBN cord-023584-yaxawqhj 243 7 to to TO cord-023584-yaxawqhj 243 8 measure measure VB cord-023584-yaxawqhj 243 9 virus virus NN cord-023584-yaxawqhj 243 10 growth growth NN cord-023584-yaxawqhj 243 11 in in IN cord-023584-yaxawqhj 243 12 antiviral antiviral JJ cord-023584-yaxawqhj 243 13 tests test NNS cord-023584-yaxawqhj 243 14 - - , cord-023584-yaxawqhj 243 15 cytopathic cytopathic JJ cord-023584-yaxawqhj 243 16 effect effect NN cord-023584-yaxawqhj 243 17 , , , cord-023584-yaxawqhj 243 18 plaque plaque NN cord-023584-yaxawqhj 243 19 reduction reduction NN cord-023584-yaxawqhj 243 20 , , , cord-023584-yaxawqhj 243 21 yield yield NN cord-023584-yaxawqhj 243 22 of of IN cord-023584-yaxawqhj 243 23 infectious infectious JJ cord-023584-yaxawqhj 243 24 virus virus NN cord-023584-yaxawqhj 243 25 , , , cord-023584-yaxawqhj 243 26 and and CC cord-023584-yaxawqhj 243 27 ht.madsorption ht.madsorption NNP cord-023584-yaxawqhj 243 28 , , , cord-023584-yaxawqhj 243 29 bring bring VB cord-023584-yaxawqhj 243 30 thc thc NN cord-023584-yaxawqhj 243 31 most most RBS cord-023584-yaxawqhj 243 32 common common JJ cord-023584-yaxawqhj 243 33 . . . cord-023584-yaxawqhj 244 1 Because because IN cord-023584-yaxawqhj 244 2 of of IN cord-023584-yaxawqhj 244 3 thcir thcir NN cord-023584-yaxawqhj 244 4 simplicity simplicity NN cord-023584-yaxawqhj 244 5 , , , cord-023584-yaxawqhj 244 6 cytopathic cytopathic JJ cord-023584-yaxawqhj 244 7 effect effect NN cord-023584-yaxawqhj 244 8 and and CC cord-023584-yaxawqhj 244 9 hcmadsorption hcmadsorption NN cord-023584-yaxawqhj 244 10 are be VBP cord-023584-yaxawqhj 244 11 widdy widdy NNP cord-023584-yaxawqhj 244 12 used use VBN cord-023584-yaxawqhj 244 13 , , , cord-023584-yaxawqhj 244 14 hut hut VB cord-023584-yaxawqhj 244 15 these these DT cord-023584-yaxawqhj 244 16 techniques technique NNS cord-023584-yaxawqhj 244 17 must must MD cord-023584-yaxawqhj 244 18 be be VB cord-023584-yaxawqhj 244 19 used use VBN cord-023584-yaxawqhj 244 20 with with IN cord-023584-yaxawqhj 244 21 some some DT cord-023584-yaxawqhj 244 22 precautions precaution NNS cord-023584-yaxawqhj 244 23 if if IN cord-023584-yaxawqhj 244 24 certain certain JJ cord-023584-yaxawqhj 244 25 types type NNS cord-023584-yaxawqhj 244 26 of of IN cord-023584-yaxawqhj 244 27 antiviral antiviral JJ cord-023584-yaxawqhj 244 28 activity activity NN cord-023584-yaxawqhj 244 29 are be VBP cord-023584-yaxawqhj 244 30 not not RB cord-023584-yaxawqhj 244 31 to to TO cord-023584-yaxawqhj 244 32 be be VB cord-023584-yaxawqhj 244 33 missed miss VBN cord-023584-yaxawqhj 244 34 . . . cord-023584-yaxawqhj 245 1 In in IN cord-023584-yaxawqhj 245 2 order order NN cord-023584-yaxawqhj 245 3 to to TO cord-023584-yaxawqhj 245 4 speed speed VB cord-023584-yaxawqhj 245 5 up up RP cord-023584-yaxawqhj 245 6 the the DT cord-023584-yaxawqhj 245 7 rate rate NN cord-023584-yaxawqhj 245 8 of of IN cord-023584-yaxawqhj 245 9 antiviral antiviral JJ cord-023584-yaxawqhj 245 10 testing testing NN cord-023584-yaxawqhj 245 11 , , , cord-023584-yaxawqhj 245 12 the the DT cord-023584-yaxawqhj 245 13 quantity quantity NN cord-023584-yaxawqhj 245 14 of of IN cord-023584-yaxawqhj 245 15 challenge challenge NN cord-023584-yaxawqhj 245 16 virus virus NN cord-023584-yaxawqhj 245 17 is be VBZ cord-023584-yaxawqhj 245 18 often often RB cord-023584-yaxawqhj 245 19 increased increase VBN cord-023584-yaxawqhj 245 20 to to IN cord-023584-yaxawqhj 245 21 a a DT cord-023584-yaxawqhj 245 22 theoretical theoretical JJ cord-023584-yaxawqhj 245 23 maximum maximum NN cord-023584-yaxawqhj 245 24 of of IN cord-023584-yaxawqhj 245 25 1 1 CD cord-023584-yaxawqhj 245 26 virus virus NN cord-023584-yaxawqhj 245 27 particle particle NN cord-023584-yaxawqhj 245 28 per per IN cord-023584-yaxawqhj 245 29 cell cell NN cord-023584-yaxawqhj 245 30 . . . cord-023584-yaxawqhj 246 1 The the DT cord-023584-yaxawqhj 246 2 whole whole JJ cord-023584-yaxawqhj 246 3 cell cell NN cord-023584-yaxawqhj 246 4 culture culture NN cord-023584-yaxawqhj 246 5 then then RB cord-023584-yaxawqhj 246 6 behaves behave VBZ cord-023584-yaxawqhj 246 7 synchronously synchronously RB cord-023584-yaxawqhj 246 8 , , , cord-023584-yaxawqhj 246 9 and and CC cord-023584-yaxawqhj 246 10 results result NNS cord-023584-yaxawqhj 246 11 are be VBP cord-023584-yaxawqhj 246 12 obtained obtain VBN cord-023584-yaxawqhj 246 13 in in IN cord-023584-yaxawqhj 246 14 whatever whatever WDT cord-023584-yaxawqhj 246 15 time time NN cord-023584-yaxawqhj 246 16 the the DT cord-023584-yaxawqhj 246 17 virus virus NN cord-023584-yaxawqhj 246 18 takes take VBZ cord-023584-yaxawqhj 246 19 to to TO cord-023584-yaxawqhj 246 20 complete complete VB cord-023584-yaxawqhj 246 21 its -PRON- PRP$ cord-023584-yaxawqhj 246 22 replicative replicative JJ cord-023584-yaxawqhj 246 23 cycle cycle NN cord-023584-yaxawqhj 246 24 - - : cord-023584-yaxawqhj 246 25 usually usually RB cord-023584-yaxawqhj 246 26 between between IN cord-023584-yaxawqhj 246 27 10 10 CD cord-023584-yaxawqhj 246 28 and and CC cord-023584-yaxawqhj 246 29 20 20 CD cord-023584-yaxawqhj 246 30 hours hour NNS cord-023584-yaxawqhj 246 31 . . . cord-023584-yaxawqhj 247 1 With with IN cord-023584-yaxawqhj 247 2 this this DT cord-023584-yaxawqhj 247 3 procedure procedure NN cord-023584-yaxawqhj 247 4 , , , cord-023584-yaxawqhj 247 5 however however RB cord-023584-yaxawqhj 247 6 . . . cord-023584-yaxawqhj 248 1 a a DT cord-023584-yaxawqhj 248 2 test test NN cord-023584-yaxawqhj 248 3 compound compound NN cord-023584-yaxawqhj 248 4 that that WDT cord-023584-yaxawqhj 248 5 prevented prevent VBD cord-023584-yaxawqhj 248 6 the the DT cord-023584-yaxawqhj 248 7 formation formation NN cord-023584-yaxawqhj 248 8 of of IN cord-023584-yaxawqhj 248 9 infectious infectious JJ cord-023584-yaxawqhj 248 10 virus virus NN cord-023584-yaxawqhj 248 11 but but CC cord-023584-yaxawqhj 248 12 was be VBD cord-023584-yaxawqhj 248 13 unable unable JJ cord-023584-yaxawqhj 248 14 to to TO cord-023584-yaxawqhj 248 15 protect protect VB cord-023584-yaxawqhj 248 16 the the DT cord-023584-yaxawqhj 248 17 infected infected JJ cord-023584-yaxawqhj 248 18 cell cell NN cord-023584-yaxawqhj 248 19 from from IN cord-023584-yaxawqhj 248 20 destruction destruction NN cord-023584-yaxawqhj 248 21 would would MD cord-023584-yaxawqhj 248 22 not not RB cord-023584-yaxawqhj 248 23 be be VB cord-023584-yaxawqhj 248 24 detected detect VBN cord-023584-yaxawqhj 248 25 . . . cord-023584-yaxawqhj 249 1 For for IN cord-023584-yaxawqhj 249 2 example example NN cord-023584-yaxawqhj 249 3 , , , cord-023584-yaxawqhj 249 4 in in IN cord-023584-yaxawqhj 249 5 a a DT cord-023584-yaxawqhj 249 6 relatively relatively RB cord-023584-yaxawqhj 249 7 complex complex JJ cord-023584-yaxawqhj 249 8 virus virus NN cord-023584-yaxawqhj 249 9 , , , cord-023584-yaxawqhj 249 10 such such JJ cord-023584-yaxawqhj 249 11 as as IN cord-023584-yaxawqhj 249 12 influenza influenza NN cord-023584-yaxawqhj 249 13 , , , cord-023584-yaxawqhj 249 14 it -PRON- PRP cord-023584-yaxawqhj 249 15 is be VBZ cord-023584-yaxawqhj 249 16 not not RB cord-023584-yaxawqhj 249 17 difficult difficult JJ cord-023584-yaxawqhj 249 18 to to TO cord-023584-yaxawqhj 249 19 imagine imagine VB cord-023584-yaxawqhj 249 20 that that IN cord-023584-yaxawqhj 249 21 RNA RNA NNP cord-023584-yaxawqhj 249 22 synthesis synthesis NN cord-023584-yaxawqhj 249 23 could could MD cord-023584-yaxawqhj 249 24 be be VB cord-023584-yaxawqhj 249 25 interrupted interrupt VBN cord-023584-yaxawqhj 249 26 while while IN cord-023584-yaxawqhj 249 27 hemagglutinin hemagglutinin NN cord-023584-yaxawqhj 249 28 production production NN cord-023584-yaxawqhj 249 29 continued continue VBD cord-023584-yaxawqhj 249 30 , , , cord-023584-yaxawqhj 249 31 much much RB cord-023584-yaxawqhj 249 32 as as IN cord-023584-yaxawqhj 249 33 it -PRON- PRP cord-023584-yaxawqhj 249 34 does do VBZ cord-023584-yaxawqhj 249 35 in in IN cord-023584-yaxawqhj 249 36 the the DT cord-023584-yaxawqhj 249 37 Van Van NNP cord-023584-yaxawqhj 249 38 Magnus Magnus NNP cord-023584-yaxawqhj 249 39 effect effect NN cord-023584-yaxawqhj 249 40 . . . cord-023584-yaxawqhj 250 1 The the DT cord-023584-yaxawqhj 250 2 result result NN cord-023584-yaxawqhj 250 3 would would MD cord-023584-yaxawqhj 250 4 be be VB cord-023584-yaxawqhj 250 5 a a DT cord-023584-yaxawqhj 250 6 monolayer monolayer NN cord-023584-yaxawqhj 250 7 showing show VBG cord-023584-yaxawqhj 250 8 full full JJ cord-023584-yaxawqhj 250 9 hemadsorption hemadsorption NN cord-023584-yaxawqhj 250 10 and and CC cord-023584-yaxawqhj 250 11 yet yet RB cord-023584-yaxawqhj 250 12 no no DT cord-023584-yaxawqhj 250 13 transmissible transmissible JJ cord-023584-yaxawqhj 250 14 virus virus NN cord-023584-yaxawqhj 250 15 would would MD cord-023584-yaxawqhj 250 16 have have VB cord-023584-yaxawqhj 250 17 been be VBN cord-023584-yaxawqhj 250 18 formed form VBN cord-023584-yaxawqhj 250 19 . . . cord-023584-yaxawqhj 251 1 Test test NN cord-023584-yaxawqhj 251 2 compounds compound NNS cord-023584-yaxawqhj 251 3 that that WDT cord-023584-yaxawqhj 251 4 produce produce VBP cord-023584-yaxawqhj 251 5 this this DT cord-023584-yaxawqhj 251 6 effect effect NN cord-023584-yaxawqhj 251 7 would would MD cord-023584-yaxawqhj 251 8 be be VB cord-023584-yaxawqhj 251 9 of of IN cord-023584-yaxawqhj 251 10 great great JJ cord-023584-yaxawqhj 251 11 interest interest NN cord-023584-yaxawqhj 251 12 as as IN cord-023584-yaxawqhj 251 13 potential potential JJ cord-023584-yaxawqhj 251 14 drugs drug NNS cord-023584-yaxawqhj 251 15 but but CC cord-023584-yaxawqhj 251 16 could could MD cord-023584-yaxawqhj 251 17 be be VB cord-023584-yaxawqhj 251 18 missed miss VBN cord-023584-yaxawqhj 251 19 in in IN cord-023584-yaxawqhj 251 20 tests test NNS cord-023584-yaxawqhj 251 21 where where WRB cord-023584-yaxawqhj 251 22 the the DT cord-023584-yaxawqhj 251 23 dose dose NN cord-023584-yaxawqhj 251 24 of of IN cord-023584-yaxawqhj 251 25 challenge challenge NN cord-023584-yaxawqhj 251 26 virus virus NN cord-023584-yaxawqhj 251 27 is be VBZ cord-023584-yaxawqhj 251 28 too too RB cord-023584-yaxawqhj 251 29 high high JJ cord-023584-yaxawqhj 251 30 . . . cord-023584-yaxawqhj 252 1 Wherever wherever WRB cord-023584-yaxawqhj 252 2 possible possible JJ cord-023584-yaxawqhj 252 3 , , , cord-023584-yaxawqhj 252 4 tests test NNS cord-023584-yaxawqhj 252 5 should should MD cord-023584-yaxawqhj 252 6 permit permit VB cord-023584-yaxawqhj 252 7 several several JJ cord-023584-yaxawqhj 252 8 cycles cycle NNS cord-023584-yaxawqhj 252 9 of of IN cord-023584-yaxawqhj 252 10 virus virus NN cord-023584-yaxawqhj 252 11 growth growth NN cord-023584-yaxawqhj 252 12 to to TO cord-023584-yaxawqhj 252 13 occur occur VB cord-023584-yaxawqhj 252 14 so so IN cord-023584-yaxawqhj 252 15 that that IN cord-023584-yaxawqhj 252 16 compounds compound NNS cord-023584-yaxawqhj 252 17 that that WDT cord-023584-yaxawqhj 252 18 interrupt interrupt VBP cord-023584-yaxawqhj 252 19 any any DT cord-023584-yaxawqhj 252 20 part part NN cord-023584-yaxawqhj 252 21 of of IN cord-023584-yaxawqhj 252 22 the the DT cord-023584-yaxawqhj 252 23 cycle cycle NN cord-023584-yaxawqhj 252 24 may may MD cord-023584-yaxawqhj 252 25 be be VB cord-023584-yaxawqhj 252 26 detected detect VBN cord-023584-yaxawqhj 252 27 . . . cord-023584-yaxawqhj 253 1 There there EX cord-023584-yaxawqhj 253 2 is be VBZ cord-023584-yaxawqhj 253 3 a a DT cord-023584-yaxawqhj 253 4 school school NN cord-023584-yaxawqhj 253 5 of of IN cord-023584-yaxawqhj 253 6 thought thought NN cord-023584-yaxawqhj 253 7 that that IN cord-023584-yaxawqhj 253 8 tissue tissue NN cord-023584-yaxawqhj 253 9 culture culture NN cord-023584-yaxawqhj 253 10 testing testing NN cord-023584-yaxawqhj 253 11 is be VBZ cord-023584-yaxawqhj 253 12 so so RB cord-023584-yaxawqhj 253 13 artificial artificial JJ cord-023584-yaxawqhj 253 14 as as IN cord-023584-yaxawqhj 253 15 to to TO cord-023584-yaxawqhj 253 16 be be VB cord-023584-yaxawqhj 253 17 of of IN cord-023584-yaxawqhj 253 18 little little JJ cord-023584-yaxawqhj 253 19 value value NN cord-023584-yaxawqhj 253 20 in in IN cord-023584-yaxawqhj 253 21 detecting detect VBG cord-023584-yaxawqhj 253 22 useful useful JJ cord-023584-yaxawqhj 253 23 antiviral antiviral JJ cord-023584-yaxawqhj 253 24 substances substance NNS cord-023584-yaxawqhj 253 25 . . . cord-023584-yaxawqhj 254 1 It -PRON- PRP cord-023584-yaxawqhj 254 2 is be VBZ cord-023584-yaxawqhj 254 3 argued argue VBN cord-023584-yaxawqhj 254 4 that that IN cord-023584-yaxawqhj 254 5 by by IN cord-023584-yaxawqhj 254 6 testing test VBG cord-023584-yaxawqhj 254 7 for for IN cord-023584-yaxawqhj 254 8 antiviral antiviral JJ cord-023584-yaxawqhj 254 9 effects effect NNS cord-023584-yaxawqhj 254 10 directly directly RB cord-023584-yaxawqhj 254 11 in in IN cord-023584-yaxawqhj 254 12 animals animal NNS cord-023584-yaxawqhj 254 13 , , , cord-023584-yaxawqhj 254 14 the the DT cord-023584-yaxawqhj 254 15 activity activity NN cord-023584-yaxawqhj 254 16 that that WDT cord-023584-yaxawqhj 254 17 is be VBZ cord-023584-yaxawqhj 254 18 detected detect VBN cord-023584-yaxawqhj 254 19 is be VBZ cord-023584-yaxawqhj 254 20 likely likely JJ cord-023584-yaxawqhj 254 21 to to TO cord-023584-yaxawqhj 254 22 be be VB cord-023584-yaxawqhj 254 23 more more RBR cord-023584-yaxawqhj 254 24 valid valid JJ cord-023584-yaxawqhj 254 25 and and CC cord-023584-yaxawqhj 254 26 more more RBR cord-023584-yaxawqhj 254 27 useful useful JJ cord-023584-yaxawqhj 254 28 than than IN cord-023584-yaxawqhj 254 29 that that DT cord-023584-yaxawqhj 254 30 detected detect VBN cord-023584-yaxawqhj 254 31 in in IN cord-023584-yaxawqhj 254 32 tissue tissue NN cord-023584-yaxawqhj 254 33 culture culture NN cord-023584-yaxawqhj 254 34 . . . cord-023584-yaxawqhj 255 1 It -PRON- PRP cord-023584-yaxawqhj 255 2 is be VBZ cord-023584-yaxawqhj 255 3 true true JJ cord-023584-yaxawqhj 255 4 that that IN cord-023584-yaxawqhj 255 5 the the DT cord-023584-yaxawqhj 255 6 majority majority NN cord-023584-yaxawqhj 255 7 of of IN cord-023584-yaxawqhj 255 8 active active JJ cord-023584-yaxawqhj 255 9 compounds compound NNS cord-023584-yaxawqhj 255 10 detected detect VBN cord-023584-yaxawqhj 255 11 in in IN cord-023584-yaxawqhj 255 12 tissue tissue NN cord-023584-yaxawqhj 255 13 culture culture NN cord-023584-yaxawqhj 255 14 screens screen NNS cord-023584-yaxawqhj 255 15 are be VBP cord-023584-yaxawqhj 255 16 not not RB cord-023584-yaxawqhj 255 17 active active JJ cord-023584-yaxawqhj 255 18 in in IN cord-023584-yaxawqhj 255 19 animals animal NNS cord-023584-yaxawqhj 255 20 , , , cord-023584-yaxawqhj 255 21 even even RB cord-023584-yaxawqhj 255 22 after after IN cord-023584-yaxawqhj 255 23 full full JJ cord-023584-yaxawqhj 255 24 authentication authentication NN cord-023584-yaxawqhj 255 25 of of IN cord-023584-yaxawqhj 255 26 the the DT cord-023584-yaxawqhj 255 27 antiviral antiviral JJ cord-023584-yaxawqhj 255 28 activity activity NN cord-023584-yaxawqhj 255 29 by by IN cord-023584-yaxawqhj 255 30 tests test NNS cord-023584-yaxawqhj 255 31 such such JJ cord-023584-yaxawqhj 255 32 as as IN cord-023584-yaxawqhj 255 33 those those DT cord-023584-yaxawqhj 255 34 discussed discuss VBN cord-023584-yaxawqhj 255 35 above above RB cord-023584-yaxawqhj 255 36 . . . cord-023584-yaxawqhj 256 1 The the DT cord-023584-yaxawqhj 256 2 reason reason NN cord-023584-yaxawqhj 256 3 for for IN cord-023584-yaxawqhj 256 4 this this DT cord-023584-yaxawqhj 256 5 is be VBZ cord-023584-yaxawqhj 256 6 usually usually RB cord-023584-yaxawqhj 256 7 that that IN cord-023584-yaxawqhj 256 8 the the DT cord-023584-yaxawqhj 256 9 compounds compound NNS cord-023584-yaxawqhj 256 10 do do VBP cord-023584-yaxawqhj 256 11 not not RB cord-023584-yaxawqhj 256 12 reach reach VB cord-023584-yaxawqhj 256 13 the the DT cord-023584-yaxawqhj 256 14 target target NN cord-023584-yaxawqhj 256 15 organs organ NNS cord-023584-yaxawqhj 256 16 in in IN cord-023584-yaxawqhj 256 17 sufficient sufficient JJ cord-023584-yaxawqhj 256 18 amounts amount NNS cord-023584-yaxawqhj 256 19 to to TO cord-023584-yaxawqhj 256 20 show show VB cord-023584-yaxawqhj 256 21 activity activity NN cord-023584-yaxawqhj 256 22 rather rather RB cord-023584-yaxawqhj 256 23 than than IN cord-023584-yaxawqhj 256 24 because because IN cord-023584-yaxawqhj 256 25 of of IN cord-023584-yaxawqhj 256 26 some some DT cord-023584-yaxawqhj 256 27 intrinsic intrinsic JJ cord-023584-yaxawqhj 256 28 defects defect NNS cord-023584-yaxawqhj 256 29 in in IN cord-023584-yaxawqhj 256 30 the the DT cord-023584-yaxawqhj 256 31 antiviral antiviral JJ cord-023584-yaxawqhj 256 32 activity activity NN cord-023584-yaxawqhj 256 33 of of IN cord-023584-yaxawqhj 256 34 the the DT cord-023584-yaxawqhj 256 35 compounds compound NNS cord-023584-yaxawqhj 256 36 . . . cord-023584-yaxawqhj 257 1 Also also RB cord-023584-yaxawqhj 257 2 , , , cord-023584-yaxawqhj 257 3 apart apart RB cord-023584-yaxawqhj 257 4 from from IN cord-023584-yaxawqhj 257 5 interferon interferon NN cord-023584-yaxawqhj 257 6 inducers inducer NNS cord-023584-yaxawqhj 257 7 , , , cord-023584-yaxawqhj 257 8 unless unless IN cord-023584-yaxawqhj 257 9 a a DT cord-023584-yaxawqhj 257 10 compound compound NN cord-023584-yaxawqhj 257 11 manifests manifest VBZ cord-023584-yaxawqhj 257 12 some some DT cord-023584-yaxawqhj 257 13 activity activity NN cord-023584-yaxawqhj 257 14 in in IN cord-023584-yaxawqhj 257 15 vitro vitro FW cord-023584-yaxawqhj 257 16 , , , cord-023584-yaxawqhj 257 17 it -PRON- PRP cord-023584-yaxawqhj 257 18 is be VBZ cord-023584-yaxawqhj 257 19 highly highly RB cord-023584-yaxawqhj 257 20 unlikely unlikely JJ cord-023584-yaxawqhj 257 21 to to TO cord-023584-yaxawqhj 257 22 do do VB cord-023584-yaxawqhj 257 23 so so RB cord-023584-yaxawqhj 257 24 in in IN cord-023584-yaxawqhj 257 25 vivo vivo NNP cord-023584-yaxawqhj 257 26 . . . cord-023584-yaxawqhj 258 1 On on IN cord-023584-yaxawqhj 258 2 the the DT cord-023584-yaxawqhj 258 3 one one CD cord-023584-yaxawqhj 258 4 hand hand NN cord-023584-yaxawqhj 258 5 , , , cord-023584-yaxawqhj 258 6 it -PRON- PRP cord-023584-yaxawqhj 258 7 is be VBZ cord-023584-yaxawqhj 258 8 argued argue VBN cord-023584-yaxawqhj 258 9 that that IN cord-023584-yaxawqhj 258 10 a a DT cord-023584-yaxawqhj 258 11 virus virus NN cord-023584-yaxawqhj 258 12 growing grow VBG cord-023584-yaxawqhj 258 13 in in IN cord-023584-yaxawqhj 258 14 a a DT cord-023584-yaxawqhj 258 15 tissue tissue NN cord-023584-yaxawqhj 258 16 culture culture NN cord-023584-yaxawqhj 258 17 cell cell NN cord-023584-yaxawqhj 258 18 is be VBZ cord-023584-yaxawqhj 258 19 of of IN cord-023584-yaxawqhj 258 20 little little JJ cord-023584-yaxawqhj 258 21 relevance relevance NN cord-023584-yaxawqhj 258 22 to to IN cord-023584-yaxawqhj 258 23 the the DT cord-023584-yaxawqhj 258 24 processes process NNS cord-023584-yaxawqhj 258 25 by by IN cord-023584-yaxawqhj 258 26 which which WDT cord-023584-yaxawqhj 258 27 that that IN cord-023584-yaxawqhj 258 28 virus virus NN cord-023584-yaxawqhj 258 29 causes cause VBZ cord-023584-yaxawqhj 258 30 disease disease NN cord-023584-yaxawqhj 258 31 in in IN cord-023584-yaxawqhj 258 32 the the DT cord-023584-yaxawqhj 258 33 whole whole JJ cord-023584-yaxawqhj 258 34 animal animal NN cord-023584-yaxawqhj 258 35 . . . cord-023584-yaxawqhj 259 1 On on IN cord-023584-yaxawqhj 259 2 the the DT cord-023584-yaxawqhj 259 3 other other JJ cord-023584-yaxawqhj 259 4 hand hand NN cord-023584-yaxawqhj 259 5 , , , cord-023584-yaxawqhj 259 6 it -PRON- PRP cord-023584-yaxawqhj 259 7 can can MD cord-023584-yaxawqhj 259 8 be be VB cord-023584-yaxawqhj 259 9 said say VBN cord-023584-yaxawqhj 259 10 that that IN cord-023584-yaxawqhj 259 11 , , , cord-023584-yaxawqhj 259 12 since since IN cord-023584-yaxawqhj 259 13 virus virus NN cord-023584-yaxawqhj 259 14 growth growth NN cord-023584-yaxawqhj 259 15 is be VBZ cord-023584-yaxawqhj 259 16 the the DT cord-023584-yaxawqhj 259 17 basis basis NN cord-023584-yaxawqhj 259 18 of of IN cord-023584-yaxawqhj 259 19 the the DT cord-023584-yaxawqhj 259 20 pathological pathological JJ cord-023584-yaxawqhj 259 21 processes process NNS cord-023584-yaxawqhj 259 22 , , , cord-023584-yaxawqhj 259 23 if if IN cord-023584-yaxawqhj 259 24 virus virus NN cord-023584-yaxawqhj 259 25 growth growth NN cord-023584-yaxawqhj 259 26 can can MD cord-023584-yaxawqhj 259 27 be be VB cord-023584-yaxawqhj 259 28 halted halt VBN cord-023584-yaxawqhj 259 29 , , , cord-023584-yaxawqhj 259 30 then then RB cord-023584-yaxawqhj 259 31 the the DT cord-023584-yaxawqhj 259 32 disease disease NN cord-023584-yaxawqhj 259 33 can can MD cord-023584-yaxawqhj 259 34 be be VB cord-023584-yaxawqhj 259 35 stopped stop VBN cord-023584-yaxawqhj 259 36 . . . cord-023584-yaxawqhj 260 1 Furthermore furthermore RB cord-023584-yaxawqhj 260 2 , , , cord-023584-yaxawqhj 260 3 the the DT cord-023584-yaxawqhj 260 4 literature literature NN cord-023584-yaxawqhj 260 5 discloses disclose VBZ cord-023584-yaxawqhj 260 6 that that IN cord-023584-yaxawqhj 260 7 some some DT cord-023584-yaxawqhj 260 8 highly highly RB cord-023584-yaxawqhj 260 9 irrelevant irrelevant JJ cord-023584-yaxawqhj 260 10 viruses virus NNS cord-023584-yaxawqhj 260 11 are be VBP cord-023584-yaxawqhj 260 12 being be VBG cord-023584-yaxawqhj 260 13 used use VBN cord-023584-yaxawqhj 260 14 in in IN cord-023584-yaxawqhj 260 15 animal animal NN cord-023584-yaxawqhj 260 16 test test NN cord-023584-yaxawqhj 260 17 systems system NNS cord-023584-yaxawqhj 260 18 and and CC cord-023584-yaxawqhj 260 19 that that IN cord-023584-yaxawqhj 260 20 , , , cord-023584-yaxawqhj 260 21 even even RB cord-023584-yaxawqhj 260 22 when when WRB cord-023584-yaxawqhj 260 23 human human JJ cord-023584-yaxawqhj 260 24 pathogens pathogen NNS cord-023584-yaxawqhj 260 25 are be VBP cord-023584-yaxawqhj 260 26 used use VBN cord-023584-yaxawqhj 260 27 , , , cord-023584-yaxawqhj 260 28 e.g. e.g. RB cord-023584-yaxawqhj 260 29 , , , cord-023584-yaxawqhj 260 30 influenza influenza NN cord-023584-yaxawqhj 260 31 , , , cord-023584-yaxawqhj 260 32 they -PRON- PRP cord-023584-yaxawqhj 260 33 require require VBP cord-023584-yaxawqhj 260 34 extensive extensive JJ cord-023584-yaxawqhj 260 35 adaption adaption NN cord-023584-yaxawqhj 260 36 to to IN cord-023584-yaxawqhj 260 37 their -PRON- PRP$ cord-023584-yaxawqhj 260 38 animal animal NN cord-023584-yaxawqhj 260 39 host host NN cord-023584-yaxawqhj 260 40 and and CC cord-023584-yaxawqhj 260 41 the the DT cord-023584-yaxawqhj 260 42 course course NN cord-023584-yaxawqhj 260 43 of of IN cord-023584-yaxawqhj 260 44 the the DT cord-023584-yaxawqhj 260 45 disease disease NN cord-023584-yaxawqhj 260 46 is be VBZ cord-023584-yaxawqhj 260 47 usually usually RB cord-023584-yaxawqhj 260 48 very very RB cord-023584-yaxawqhj 260 49 different different JJ cord-023584-yaxawqhj 260 50 from from IN cord-023584-yaxawqhj 260 51 that that DT cord-023584-yaxawqhj 260 52 in in IN cord-023584-yaxawqhj 260 53 humans human NNS cord-023584-yaxawqhj 260 54 . . . cord-023584-yaxawqhj 261 1 Finally finally RB cord-023584-yaxawqhj 261 2 , , , cord-023584-yaxawqhj 261 3 there there EX cord-023584-yaxawqhj 261 4 are be VBP cord-023584-yaxawqhj 261 5 no no DT cord-023584-yaxawqhj 261 6 convenient convenient JJ cord-023584-yaxawqhj 261 7 animal animal NN cord-023584-yaxawqhj 261 8 models model NNS cord-023584-yaxawqhj 261 9 for for IN cord-023584-yaxawqhj 261 10 studying study VBG cord-023584-yaxawqhj 261 11 the the DT cord-023584-yaxawqhj 261 12 growth growth NN cord-023584-yaxawqhj 261 13 of of IN cord-023584-yaxawqhj 261 14 human human JJ cord-023584-yaxawqhj 261 15 rhino rhino NN cord-023584-yaxawqhj 261 16 - - HYPH cord-023584-yaxawqhj 261 17 and and CC cord-023584-yaxawqhj 261 18 coronaviruses coronaviruse NNS cord-023584-yaxawqhj 261 19 and and CC cord-023584-yaxawqhj 261 20 , , , cord-023584-yaxawqhj 261 21 unless unless IN cord-023584-yaxawqhj 261 22 tissue tissue NN cord-023584-yaxawqhj 261 23 culture culture NN cord-023584-yaxawqhj 261 24 tests test NNS cord-023584-yaxawqhj 261 25 are be VBP cord-023584-yaxawqhj 261 26 used use VBN cord-023584-yaxawqhj 261 27 , , , cord-023584-yaxawqhj 261 28 there there EX cord-023584-yaxawqhj 261 29 could could MD cord-023584-yaxawqhj 261 30 be be VB cord-023584-yaxawqhj 261 31 no no DT cord-023584-yaxawqhj 261 32 screening screening NN cord-023584-yaxawqhj 261 33 for for IN cord-023584-yaxawqhj 261 34 antiviral antiviral JJ cord-023584-yaxawqhj 261 35 compounds compound NNS cord-023584-yaxawqhj 261 36 against against IN cord-023584-yaxawqhj 261 37 these these DT cord-023584-yaxawqhj 261 38 important important JJ cord-023584-yaxawqhj 261 39 pathogens pathogen NNS cord-023584-yaxawqhj 261 40 . . . cord-023584-yaxawqhj 262 1 There there EX cord-023584-yaxawqhj 262 2 is be VBZ cord-023584-yaxawqhj 262 3 , , , cord-023584-yaxawqhj 262 4 therefore therefore RB cord-023584-yaxawqhj 262 5 , , , cord-023584-yaxawqhj 262 6 no no DT cord-023584-yaxawqhj 262 7 convincing convincing JJ cord-023584-yaxawqhj 262 8 theoretical theoretical JJ cord-023584-yaxawqhj 262 9 advantage advantage NN cord-023584-yaxawqhj 262 10 in in IN cord-023584-yaxawqhj 262 11 using use VBG cord-023584-yaxawqhj 262 12 animals animal NNS cord-023584-yaxawqhj 262 13 for for IN cord-023584-yaxawqhj 262 14 routine routine JJ cord-023584-yaxawqhj 262 15 antiviral antiviral JJ cord-023584-yaxawqhj 262 16 screens screen NNS cord-023584-yaxawqhj 262 17 . . . cord-023584-yaxawqhj 263 1 This this DT cord-023584-yaxawqhj 263 2 , , , cord-023584-yaxawqhj 263 3 together together RB cord-023584-yaxawqhj 263 4 with with IN cord-023584-yaxawqhj 263 5 the the DT cord-023584-yaxawqhj 263 6 cumbersome cumbersome JJ cord-023584-yaxawqhj 263 7 nature nature NN cord-023584-yaxawqhj 263 8 of of IN cord-023584-yaxawqhj 263 9 animal animal NN cord-023584-yaxawqhj 263 10 tests test NNS cord-023584-yaxawqhj 263 11 and and CC cord-023584-yaxawqhj 263 12 the the DT cord-023584-yaxawqhj 263 13 difficulties difficulty NNS cord-023584-yaxawqhj 263 14 of of IN cord-023584-yaxawqhj 263 15 " " `` cord-023584-yaxawqhj 263 16 scaling scale VBG cord-023584-yaxawqhj 263 17 - - HYPH cord-023584-yaxawqhj 263 18 up up RP cord-023584-yaxawqhj 263 19 " " '' cord-023584-yaxawqhj 263 20 to to TO cord-023584-yaxawqhj 263 21 test test VB cord-023584-yaxawqhj 263 22 large large JJ cord-023584-yaxawqhj 263 23 numbers number NNS cord-023584-yaxawqhj 263 24 of of IN cord-023584-yaxawqhj 263 25 compounds compound NNS cord-023584-yaxawqhj 263 26 makes make VBZ cord-023584-yaxawqhj 263 27 tissue tissue NN cord-023584-yaxawqhj 263 28 culture culture NN cord-023584-yaxawqhj 263 29 testing test VBG cord-023584-yaxawqhj 263 30 a a DT cord-023584-yaxawqhj 263 31 more more RBR cord-023584-yaxawqhj 263 32 attractive attractive JJ cord-023584-yaxawqhj 263 33 proposition proposition NN cord-023584-yaxawqhj 263 34 for for IN cord-023584-yaxawqhj 263 35 the the DT cord-023584-yaxawqhj 263 36 initial initial JJ cord-023584-yaxawqhj 263 37 screening screening NN cord-023584-yaxawqhj 263 38 program program NN cord-023584-yaxawqhj 263 39 . . . cord-023584-yaxawqhj 264 1 The the DT cord-023584-yaxawqhj 264 2 foregoing forego VBG cord-023584-yaxawqhj 264 3 remarks remark NNS cord-023584-yaxawqhj 264 4 apply apply VBP cord-023584-yaxawqhj 264 5 , , , cord-023584-yaxawqhj 264 6 of of IN cord-023584-yaxawqhj 264 7 course course NN cord-023584-yaxawqhj 264 8 , , , cord-023584-yaxawqhj 264 9 only only RB cord-023584-yaxawqhj 264 10 to to IN cord-023584-yaxawqhj 264 11 the the DT cord-023584-yaxawqhj 264 12 detection detection NN cord-023584-yaxawqhj 264 13 of of IN cord-023584-yaxawqhj 264 14 compounds compound NNS cord-023584-yaxawqhj 264 15 that that WDT cord-023584-yaxawqhj 264 16 have have VBP cord-023584-yaxawqhj 264 17 a a DT cord-023584-yaxawqhj 264 18 direct direct JJ cord-023584-yaxawqhj 264 19 effect effect NN cord-023584-yaxawqhj 264 20 on on IN cord-023584-yaxawqhj 264 21 specific specific JJ cord-023584-yaxawqhj 264 22 virus virus NN cord-023584-yaxawqhj 264 23 processes process NNS cord-023584-yaxawqhj 264 24 , , , cord-023584-yaxawqhj 264 25 e.g. e.g. RB cord-023584-yaxawqhj 264 26 , , , cord-023584-yaxawqhj 264 27 absorption absorption NN cord-023584-yaxawqhj 264 28 , , , cord-023584-yaxawqhj 264 29 penetration penetration NN cord-023584-yaxawqhj 264 30 , , , cord-023584-yaxawqhj 264 31 and and CC cord-023584-yaxawqhj 264 32 replication replication NN cord-023584-yaxawqhj 264 33 . . . cord-023584-yaxawqhj 265 1 In in IN cord-023584-yaxawqhj 265 2 the the DT cord-023584-yaxawqhj 265 3 field field NN cord-023584-yaxawqhj 265 4 of of IN cord-023584-yaxawqhj 265 5 interferon interferon NN cord-023584-yaxawqhj 265 6 inducers inducer NNS cord-023584-yaxawqhj 265 7 , , , cord-023584-yaxawqhj 265 8 immune immune JJ cord-023584-yaxawqhj 265 9 enhancers enhancer NNS cord-023584-yaxawqhj 265 10 , , , cord-023584-yaxawqhj 265 11 and and CC cord-023584-yaxawqhj 265 12 other other JJ cord-023584-yaxawqhj 265 13 stimulators stimulator NNS cord-023584-yaxawqhj 265 14 of of IN cord-023584-yaxawqhj 265 15 thr thr NNP cord-023584-yaxawqhj 265 16 host host NN cord-023584-yaxawqhj 265 17 defense defense NN cord-023584-yaxawqhj 265 18 mechanisms mechanism NNS cord-023584-yaxawqhj 265 19 , , , cord-023584-yaxawqhj 265 20 obviously obviously RB cord-023584-yaxawqhj 265 21 one one PRP cord-023584-yaxawqhj 265 22 has have VBZ cord-023584-yaxawqhj 265 23 no no DT cord-023584-yaxawqhj 265 24 choice choice NN cord-023584-yaxawqhj 265 25 but but IN cord-023584-yaxawqhj 265 26 to to TO cord-023584-yaxawqhj 265 27 use use VB cord-023584-yaxawqhj 265 28 test test NN cord-023584-yaxawqhj 265 29 animals animal NNS cord-023584-yaxawqhj 265 30 ; ; : cord-023584-yaxawqhj 265 31 but but CC cord-023584-yaxawqhj 265 32 here here RB cord-023584-yaxawqhj 265 33 one one CD cord-023584-yaxawqhj 265 34 is be VBZ cord-023584-yaxawqhj 265 35 concerned concerned JJ cord-023584-yaxawqhj 265 36 to to TO cord-023584-yaxawqhj 265 37 detect detect VB cord-023584-yaxawqhj 265 38 any any DT cord-023584-yaxawqhj 265 39 overall overall JJ cord-023584-yaxawqhj 265 40 rffcct rffcct NN cord-023584-yaxawqhj 265 41 on on IN cord-023584-yaxawqhj 265 42 the the DT cord-023584-yaxawqhj 265 43 course course NN cord-023584-yaxawqhj 265 44 of of IN cord-023584-yaxawqhj 265 45 a a DT cord-023584-yaxawqhj 265 46 disease disease NN cord-023584-yaxawqhj 265 47 rathrr rathrr NN cord-023584-yaxawqhj 265 48 than than IN cord-023584-yaxawqhj 265 49 accurately accurately RB cord-023584-yaxawqhj 265 50 t t NNP cord-023584-yaxawqhj 265 51 o o NN cord-023584-yaxawqhj 265 52 model model NN cord-023584-yaxawqhj 265 53 a a DT cord-023584-yaxawqhj 265 54 particular particular JJ cord-023584-yaxawqhj 265 55 human human JJ cord-023584-yaxawqhj 265 56 or or CC cord-023584-yaxawqhj 265 57 veterinary veterinary JJ cord-023584-yaxawqhj 265 58 infection infection NN cord-023584-yaxawqhj 265 59 . . . cord-023584-yaxawqhj 266 1 Accordingly accordingly RB cord-023584-yaxawqhj 266 2 , , , cord-023584-yaxawqhj 266 3 the the DT cord-023584-yaxawqhj 266 4 choice choice NN cord-023584-yaxawqhj 266 5 of of IN cord-023584-yaxawqhj 266 6 test test NN cord-023584-yaxawqhj 266 7 system system NN cord-023584-yaxawqhj 266 8 is be VBZ cord-023584-yaxawqhj 266 9 less less RBR cord-023584-yaxawqhj 266 10 critical critical JJ cord-023584-yaxawqhj 266 11 provided provide VBN cord-023584-yaxawqhj 266 12 it -PRON- PRP cord-023584-yaxawqhj 266 13 fulfills fulfill VBZ cord-023584-yaxawqhj 266 14 certain certain JJ cord-023584-yaxawqhj 266 15 requirements requirement NNS cord-023584-yaxawqhj 266 16 . . . cord-023584-yaxawqhj 267 1 For for IN cord-023584-yaxawqhj 267 2 instancc instancc NNP cord-023584-yaxawqhj 267 3 , , , cord-023584-yaxawqhj 267 4 ( ( -LRB- cord-023584-yaxawqhj 267 5 a a LS cord-023584-yaxawqhj 267 6 ) ) -RRB- cord-023584-yaxawqhj 267 7 thr thr NNP cord-023584-yaxawqhj 267 8 virus virus NN cord-023584-yaxawqhj 267 9 and and CC cord-023584-yaxawqhj 267 10 test test NN cord-023584-yaxawqhj 267 11 compound compound NN cord-023584-yaxawqhj 267 12 should should MD cord-023584-yaxawqhj 267 13 be be VB cord-023584-yaxawqhj 267 14 administered administer VBN cord-023584-yaxawqhj 267 15 a a DT cord-023584-yaxawqhj 267 16 t t NN cord-023584-yaxawqhj 267 17 separate separate JJ cord-023584-yaxawqhj 267 18 sites site NNS cord-023584-yaxawqhj 267 19 to to TO cord-023584-yaxawqhj 267 20 avoid avoid VB cord-023584-yaxawqhj 267 21 any any DT cord-023584-yaxawqhj 267 22 possible possible JJ cord-023584-yaxawqhj 267 23 local local JJ cord-023584-yaxawqhj 267 24 destruction destruction NN cord-023584-yaxawqhj 267 25 of of IN cord-023584-yaxawqhj 267 26 the the DT cord-023584-yaxawqhj 267 27 challenge challenge NN cord-023584-yaxawqhj 267 28 virus virus NN cord-023584-yaxawqhj 267 29 by by IN cord-023584-yaxawqhj 267 30 test test NN cord-023584-yaxawqhj 267 31 compound compound NN cord-023584-yaxawqhj 267 32 ; ; : cord-023584-yaxawqhj 267 33 ( ( -LRB- cord-023584-yaxawqhj 267 34 6 6 LS cord-023584-yaxawqhj 267 35 ) ) -RRB- cord-023584-yaxawqhj 267 36 the the DT cord-023584-yaxawqhj 267 37 test test NN cord-023584-yaxawqhj 267 38 compound compound NN cord-023584-yaxawqhj 267 39 should should MD cord-023584-yaxawqhj 267 40 be be VB cord-023584-yaxawqhj 267 41 given give VBN cord-023584-yaxawqhj 267 42 parenterally parenterally NN cord-023584-yaxawqhj 267 43 to to TO cord-023584-yaxawqhj 267 44 give give VB cord-023584-yaxawqhj 267 45 the the DT cord-023584-yaxawqhj 267 46 best good JJS cord-023584-yaxawqhj 267 47 chance chance NN cord-023584-yaxawqhj 267 48 of of IN cord-023584-yaxawqhj 267 49 absorption absorption NN cord-023584-yaxawqhj 267 50 , , , cord-023584-yaxawqhj 267 51 and and CC cord-023584-yaxawqhj 267 52 ( ( -LRB- cord-023584-yaxawqhj 267 53 c c NN cord-023584-yaxawqhj 267 54 ) ) -RRB- cord-023584-yaxawqhj 267 55 the the DT cord-023584-yaxawqhj 267 56 dose dose NN cord-023584-yaxawqhj 267 57 of of IN cord-023584-yaxawqhj 267 58 challenge challenge NN cord-023584-yaxawqhj 267 59 virus virus NN cord-023584-yaxawqhj 267 60 should should MD cord-023584-yaxawqhj 267 61 be be VB cord-023584-yaxawqhj 267 62 sufficiently sufficiently RB cord-023584-yaxawqhj 267 63 small small JJ cord-023584-yaxawqhj 267 64 to to TO cord-023584-yaxawqhj 267 65 allow allow VB cord-023584-yaxawqhj 267 66 a a DT cord-023584-yaxawqhj 267 67 useful useful JJ cord-023584-yaxawqhj 267 68 incubation incubation NN cord-023584-yaxawqhj 267 69 period period NN cord-023584-yaxawqhj 267 70 before before IN cord-023584-yaxawqhj 267 71 symptoms symptom NNS cord-023584-yaxawqhj 267 72 develop develop VBP cord-023584-yaxawqhj 267 73 . . . cord-023584-yaxawqhj 268 1 The the DT cord-023584-yaxawqhj 268 2 following follow VBG cord-023584-yaxawqhj 268 3 system system NN cord-023584-yaxawqhj 268 4 has have VBZ cord-023584-yaxawqhj 268 5 been be VBN cord-023584-yaxawqhj 268 6 used use VBN cord-023584-yaxawqhj 268 7 successfully successfully RB cord-023584-yaxawqhj 268 8 by by IN cord-023584-yaxawqhj 268 9 us -PRON- PRP cord-023584-yaxawqhj 268 10 . . . cord-023584-yaxawqhj 269 1 Groups group NNS cord-023584-yaxawqhj 269 2 of of IN cord-023584-yaxawqhj 269 3 5 5 CD cord-023584-yaxawqhj 269 4 mice mouse NNS cord-023584-yaxawqhj 269 5 are be VBP cord-023584-yaxawqhj 269 6 dosed dose VBN cord-023584-yaxawqhj 269 7 intraperitoneally intraperitoneally RB cord-023584-yaxawqhj 269 8 with with IN cord-023584-yaxawqhj 269 9 test test NN cord-023584-yaxawqhj 269 10 compounds compound NNS cord-023584-yaxawqhj 269 11 a a DT cord-023584-yaxawqhj 269 12 t t NN cord-023584-yaxawqhj 269 13 50 50 CD cord-023584-yaxawqhj 269 14 , , , cord-023584-yaxawqhj 269 15 12.5 12.5 CD cord-023584-yaxawqhj 269 16 , , , cord-023584-yaxawqhj 269 17 and and CC cord-023584-yaxawqhj 269 18 3.1 3.1 CD cord-023584-yaxawqhj 269 19 mg/ mg/ NN cord-023584-yaxawqhj 269 20 kg kg NN cord-023584-yaxawqhj 269 21 on on IN cord-023584-yaxawqhj 269 22 four four CD cord-023584-yaxawqhj 269 23 successive successive JJ cord-023584-yaxawqhj 269 24 days day NNS cord-023584-yaxawqhj 269 25 . . . cord-023584-yaxawqhj 270 1 Twenty twenty CD cord-023584-yaxawqhj 270 2 - - HYPH cord-023584-yaxawqhj 270 3 four four CD cord-023584-yaxawqhj 270 4 hours hour NNS cord-023584-yaxawqhj 270 5 after after IN cord-023584-yaxawqhj 270 6 the the DT cord-023584-yaxawqhj 270 7 first first JJ cord-023584-yaxawqhj 270 8 dose dose NN cord-023584-yaxawqhj 270 9 , , , cord-023584-yaxawqhj 270 10 they -PRON- PRP cord-023584-yaxawqhj 270 11 are be VBP cord-023584-yaxawqhj 270 12 challenged challenge VBN cord-023584-yaxawqhj 270 13 intramuscularly intramuscularly RB cord-023584-yaxawqhj 270 14 with with IN cord-023584-yaxawqhj 270 15 100 100 CD cord-023584-yaxawqhj 270 16 JILD JILD NNS cord-023584-yaxawqhj 270 17 , , , cord-023584-yaxawqhj 270 18 , , , cord-023584-yaxawqhj 270 19 of of IN cord-023584-yaxawqhj 270 20 Semliki Semliki NNP cord-023584-yaxawqhj 270 21 Forest Forest NNP cord-023584-yaxawqhj 270 22 virus virus NN cord-023584-yaxawqhj 270 23 , , , cord-023584-yaxawqhj 270 24 and and CC cord-023584-yaxawqhj 270 25 after after IN cord-023584-yaxawqhj 270 26 the the DT cord-023584-yaxawqhj 270 27 last last JJ cord-023584-yaxawqhj 270 28 dose dose NN cord-023584-yaxawqhj 270 29 they -PRON- PRP cord-023584-yaxawqhj 270 30 are be VBP cord-023584-yaxawqhj 270 31 observed observe VBN cord-023584-yaxawqhj 270 32 for for IN cord-023584-yaxawqhj 270 33 symptoms symptom NNS cord-023584-yaxawqhj 270 34 twice twice RB cord-023584-yaxawqhj 270 35 daily daily RB cord-023584-yaxawqhj 270 36 . . . cord-023584-yaxawqhj 271 1 The the DT cord-023584-yaxawqhj 271 2 mcan mcan NNP cord-023584-yaxawqhj 271 3 rcciprocal rcciprocal NNP cord-023584-yaxawqhj 271 4 day day NN cord-023584-yaxawqhj 271 5 of of IN cord-023584-yaxawqhj 271 6 death death NN cord-023584-yaxawqhj 271 7 ( ( -LRB- cord-023584-yaxawqhj 271 8 MRDD MRDD NNP cord-023584-yaxawqhj 271 9 ) ) -RRB- cord-023584-yaxawqhj 271 10 for for IN cord-023584-yaxawqhj 271 11 each each DT cord-023584-yaxawqhj 271 12 test test NN cord-023584-yaxawqhj 271 13 group group NN cord-023584-yaxawqhj 271 14 is be VBZ cord-023584-yaxawqhj 271 15 calculated calculate VBN cord-023584-yaxawqhj 271 16 after after IN cord-023584-yaxawqhj 271 17 14 14 CD cord-023584-yaxawqhj 271 18 days day NNS cord-023584-yaxawqhj 271 19 and and CC cord-023584-yaxawqhj 271 20 comparcd comparcd NNS cord-023584-yaxawqhj 271 21 with with IN cord-023584-yaxawqhj 271 22 that that DT cord-023584-yaxawqhj 271 23 of of IN cord-023584-yaxawqhj 271 24 a a DT cord-023584-yaxawqhj 271 25 similar similar JJ cord-023584-yaxawqhj 271 26 undosed undosed JJ cord-023584-yaxawqhj 271 27 group group NN cord-023584-yaxawqhj 271 28 as as IN cord-023584-yaxawqhj 271 29 w w NNP cord-023584-yaxawqhj 271 30 l l NNP cord-023584-yaxawqhj 271 31 l l NNP cord-023584-yaxawqhj 271 32 as as IN cord-023584-yaxawqhj 271 33 with with IN cord-023584-yaxawqhj 271 34 that that DT cord-023584-yaxawqhj 271 35 of of IN cord-023584-yaxawqhj 271 36 a a DT cord-023584-yaxawqhj 271 37 group group NN cord-023584-yaxawqhj 271 38 givcn givcn NNP cord-023584-yaxawqhj 271 39 four four CD cord-023584-yaxawqhj 271 40 daily daily JJ cord-023584-yaxawqhj 271 41 injections injection NNS cord-023584-yaxawqhj 271 42 of of IN cord-023584-yaxawqhj 271 43 a a DT cord-023584-yaxawqhj 271 44 protective protective JJ cord-023584-yaxawqhj 271 45 agent agent NN cord-023584-yaxawqhj 271 46 such such JJ cord-023584-yaxawqhj 271 47 as as IN cord-023584-yaxawqhj 271 48 polyinsinie polyinsinie NNP cord-023584-yaxawqhj 271 49 - - HYPH cord-023584-yaxawqhj 271 50 polyrytidilir polyrytidilir NNP cord-023584-yaxawqhj 271 51 acid acid NN cord-023584-yaxawqhj 271 52 ( ( -LRB- cord-023584-yaxawqhj 271 53 poly poly JJ cord-023584-yaxawqhj 271 54 IC IC NNP cord-023584-yaxawqhj 271 55 ) ) -RRB- cord-023584-yaxawqhj 271 56 . . . cord-023584-yaxawqhj 272 1 Figure figure NN cord-023584-yaxawqhj 272 2 4 4 CD cord-023584-yaxawqhj 272 3 shows show VBZ cord-023584-yaxawqhj 272 4 the the DT cord-023584-yaxawqhj 272 5 typical typical JJ cord-023584-yaxawqhj 272 6 response response NN cord-023584-yaxawqhj 272 7 of of IN cord-023584-yaxawqhj 272 8 mice mouse NNS cord-023584-yaxawqhj 272 9 treated treat VBD cord-023584-yaxawqhj 272 10 nith nith NNP cord-023584-yaxawqhj 272 11 poly poly NNP cord-023584-yaxawqhj 272 12 IC IC NNP cord-023584-yaxawqhj 272 13 and and CC cord-023584-yaxawqhj 272 14 untreated untreated JJ cord-023584-yaxawqhj 272 15 controls control NNS cord-023584-yaxawqhj 272 16 . . . cord-023584-yaxawqhj 273 1 Under under IN cord-023584-yaxawqhj 273 2 these these DT cord-023584-yaxawqhj 273 3 particular particular JJ cord-023584-yaxawqhj 273 4 conditions condition NNS cord-023584-yaxawqhj 273 5 , , , cord-023584-yaxawqhj 273 6 the the DT cord-023584-yaxawqhj 273 7 t~7 t~7 CD cord-023584-yaxawqhj 273 8 0 0 CD cord-023584-yaxawqhj 273 9 response response NN cord-023584-yaxawqhj 273 10 curves curve NNS cord-023584-yaxawqhj 273 11 overlap overlap VBP cord-023584-yaxawqhj 273 12 . . . cord-023584-yaxawqhj 274 1 By by IN cord-023584-yaxawqhj 274 2 selecting select VBG cord-023584-yaxawqhj 274 3 an an DT cord-023584-yaxawqhj 274 4 MRDD mrdd NN cord-023584-yaxawqhj 274 5 of of IN cord-023584-yaxawqhj 274 6 0.133 0.133 CD cord-023584-yaxawqhj 274 7 as as IN cord-023584-yaxawqhj 274 8 the the DT cord-023584-yaxawqhj 274 9 criterion criterion NN cord-023584-yaxawqhj 274 10 of of IN cord-023584-yaxawqhj 274 11 " " `` cord-023584-yaxawqhj 274 12 active active JJ cord-023584-yaxawqhj 274 13 " " '' cord-023584-yaxawqhj 274 14 or or CC cord-023584-yaxawqhj 274 15 ' ' `` cord-023584-yaxawqhj 274 16 5nactive 5nactive CD cord-023584-yaxawqhj 274 17 , , , cord-023584-yaxawqhj 274 18 " " '' cord-023584-yaxawqhj 274 19 then then RB cord-023584-yaxawqhj 274 20 theoretically theoretically RB cord-023584-yaxawqhj 274 21 10 10 CD cord-023584-yaxawqhj 274 22 % % NN cord-023584-yaxawqhj 274 23 of of IN cord-023584-yaxawqhj 274 24 all all DT cord-023584-yaxawqhj 274 25 inactive inactive JJ cord-023584-yaxawqhj 274 26 compounds compound NNS cord-023584-yaxawqhj 274 27 tested test VBN cord-023584-yaxawqhj 274 28 will will MD cord-023584-yaxawqhj 274 29 appear appear VB cord-023584-yaxawqhj 274 30 as as RB cord-023584-yaxawqhj 274 31 spurious spurious JJ cord-023584-yaxawqhj 274 32 actives active NNS cord-023584-yaxawqhj 274 33 and and CC cord-023584-yaxawqhj 274 34 would would MD cord-023584-yaxawqhj 274 35 require require VB cord-023584-yaxawqhj 274 36 to to TO cord-023584-yaxawqhj 274 37 be be VB cord-023584-yaxawqhj 274 38 retested reteste VBN cord-023584-yaxawqhj 274 39 to to TO cord-023584-yaxawqhj 274 40 establish establish VB cord-023584-yaxawqhj 274 41 their -PRON- PRP$ cord-023584-yaxawqhj 274 42 true true JJ cord-023584-yaxawqhj 274 43 status status NN cord-023584-yaxawqhj 274 44 . . . cord-023584-yaxawqhj 275 1 Some some DT cord-023584-yaxawqhj 275 2 caution caution NN cord-023584-yaxawqhj 275 3 is be VBZ cord-023584-yaxawqhj 275 4 needed need VBN cord-023584-yaxawqhj 275 5 in in IN cord-023584-yaxawqhj 275 6 interpreting interpret VBG cord-023584-yaxawqhj 275 7 the the DT cord-023584-yaxawqhj 275 8 converse converse NN cord-023584-yaxawqhj 275 9 overlap overlap NN cord-023584-yaxawqhj 275 10 . . . cord-023584-yaxawqhj 276 1 Given give VBN cord-023584-yaxawqhj 276 2 100 100 CD cord-023584-yaxawqhj 276 3 known know VBN cord-023584-yaxawqhj 276 4 active active JJ cord-023584-yaxawqhj 276 5 compounds compound NNS cord-023584-yaxawqhj 276 6 , , , cord-023584-yaxawqhj 276 7 or or CC cord-023584-yaxawqhj 276 8 a a DT cord-023584-yaxawqhj 276 9 single single JJ cord-023584-yaxawqhj 276 10 active active JJ cord-023584-yaxawqhj 276 11 compound compound NN cord-023584-yaxawqhj 276 12 tested test VBN cord-023584-yaxawqhj 276 13 100 100 CD cord-023584-yaxawqhj 276 14 times time NNS cord-023584-yaxawqhj 276 15 , , , cord-023584-yaxawqhj 276 16 then then RB cord-023584-yaxawqhj 276 17 6 6 CD cord-023584-yaxawqhj 276 18 tests test NNS cord-023584-yaxawqhj 276 19 in in IN cord-023584-yaxawqhj 276 20 every every DT cord-023584-yaxawqhj 276 21 100 100 CD cord-023584-yaxawqhj 276 22 would would MD cord-023584-yaxawqhj 276 23 miss miss VB cord-023584-yaxawqhj 276 24 such such PDT cord-023584-yaxawqhj 276 25 a a DT cord-023584-yaxawqhj 276 26 compound compound NN cord-023584-yaxawqhj 276 27 . . . cord-023584-yaxawqhj 277 1 But but CC cord-023584-yaxawqhj 277 2 in in IN cord-023584-yaxawqhj 277 3 practice practice NN cord-023584-yaxawqhj 277 4 , , , cord-023584-yaxawqhj 277 5 the the DT cord-023584-yaxawqhj 277 6 vast vast JJ cord-023584-yaxawqhj 277 7 majority majority NN cord-023584-yaxawqhj 277 8 of of IN cord-023584-yaxawqhj 277 9 compounds compound NNS cord-023584-yaxawqhj 277 10 passing pass VBG cord-023584-yaxawqhj 277 11 through through IN cord-023584-yaxawqhj 277 12 the the DT cord-023584-yaxawqhj 277 13 test test NN cord-023584-yaxawqhj 277 14 will will MD cord-023584-yaxawqhj 277 15 be be VB cord-023584-yaxawqhj 277 16 inactive inactive JJ cord-023584-yaxawqhj 277 17 , , , cord-023584-yaxawqhj 277 18 and and CC cord-023584-yaxawqhj 277 19 the the DT cord-023584-yaxawqhj 277 20 chance chance NN cord-023584-yaxawqhj 277 21 that that IN cord-023584-yaxawqhj 277 22 the the DT cord-023584-yaxawqhj 277 23 occasional occasional JJ cord-023584-yaxawqhj 277 24 true true JJ cord-023584-yaxawqhj 277 25 active active JJ cord-023584-yaxawqhj 277 26 compound compound NN cord-023584-yaxawqhj 277 27 will will MD cord-023584-yaxawqhj 277 28 by by IN cord-023584-yaxawqhj 277 29 chance chance NN cord-023584-yaxawqhj 277 30 fall fall VB cord-023584-yaxawqhj 277 31 into into IN cord-023584-yaxawqhj 277 32 the the DT cord-023584-yaxawqhj 277 33 " " `` cord-023584-yaxawqhj 277 34 6 6 CD cord-023584-yaxawqhj 277 35 % % NN cord-023584-yaxawqhj 277 36 missed miss VBN cord-023584-yaxawqhj 277 37 " " '' cord-023584-yaxawqhj 277 38 category category NN cord-023584-yaxawqhj 277 39 is be VBZ cord-023584-yaxawqhj 277 40 correspondingly correspondingly RB cord-023584-yaxawqhj 277 41 reduced reduce VBN cord-023584-yaxawqhj 277 42 . . . cord-023584-yaxawqhj 278 1 Even even RB cord-023584-yaxawqhj 278 2 with with IN cord-023584-yaxawqhj 278 3 an an DT cord-023584-yaxawqhj 278 4 in in IN cord-023584-yaxawqhj 278 5 vivo vivo NN cord-023584-yaxawqhj 278 6 test test NN cord-023584-yaxawqhj 278 7 reduced reduce VBN cord-023584-yaxawqhj 278 8 to to IN cord-023584-yaxawqhj 278 9 such such PDT cord-023584-yaxawqhj 278 10 a a DT cord-023584-yaxawqhj 278 11 minimum minimum NN cord-023584-yaxawqhj 278 12 as as IN cord-023584-yaxawqhj 278 13 this this DT cord-023584-yaxawqhj 278 14 , , , cord-023584-yaxawqhj 278 15 it -PRON- PRP cord-023584-yaxawqhj 278 16 still still RB cord-023584-yaxawqhj 278 17 requires require VBZ cord-023584-yaxawqhj 278 18 a a DT cord-023584-yaxawqhj 278 19 large large JJ cord-023584-yaxawqhj 278 20 effort effort NN cord-023584-yaxawqhj 278 21 in in IN cord-023584-yaxawqhj 278 22 terms term NNS cord-023584-yaxawqhj 278 23 of of IN cord-023584-yaxawqhj 278 24 manpower manpower NN cord-023584-yaxawqhj 278 25 and and CC cord-023584-yaxawqhj 278 26 facilities facility NNS cord-023584-yaxawqhj 278 27 to to TO cord-023584-yaxawqhj 278 28 test test VB cord-023584-yaxawqhj 278 29 realistic realistic JJ cord-023584-yaxawqhj 278 30 numbers number NNS cord-023584-yaxawqhj 278 31 of of IN cord-023584-yaxawqhj 278 32 compounds compound NNS cord-023584-yaxawqhj 278 33 . . . cord-023584-yaxawqhj 279 1 Although although IN cord-023584-yaxawqhj 279 2 many many JJ cord-023584-yaxawqhj 279 3 human human JJ cord-023584-yaxawqhj 279 4 viruses virus NNS cord-023584-yaxawqhj 279 5 will will MD cord-023584-yaxawqhj 279 6 grow grow VB cord-023584-yaxawqhj 279 7 in in IN cord-023584-yaxawqhj 279 8 animal animal NN cord-023584-yaxawqhj 279 9 hosts host NNS cord-023584-yaxawqhj 279 10 it -PRON- PRP cord-023584-yaxawqhj 279 11 is be VBZ cord-023584-yaxawqhj 279 12 often often RB cord-023584-yaxawqhj 279 13 difficult difficult JJ cord-023584-yaxawqhj 279 14 to to TO cord-023584-yaxawqhj 279 15 assess assess VB cord-023584-yaxawqhj 279 16 the the DT cord-023584-yaxawqhj 279 17 potential potential JJ cord-023584-yaxawqhj 279 18 value value NN cord-023584-yaxawqhj 279 19 of of IN cord-023584-yaxawqhj 279 20 an an DT cord-023584-yaxawqhj 279 21 antiviral antiviral JJ cord-023584-yaxawqhj 279 22 compound compound NN cord-023584-yaxawqhj 279 23 for for IN cord-023584-yaxawqhj 279 24 human human JJ cord-023584-yaxawqhj 279 25 use use NN cord-023584-yaxawqhj 279 26 by by IN cord-023584-yaxawqhj 279 27 using use VBG cord-023584-yaxawqhj 279 28 animal animal NN cord-023584-yaxawqhj 279 29 models model NNS cord-023584-yaxawqhj 279 30 . . . cord-023584-yaxawqhj 280 1 There there EX cord-023584-yaxawqhj 280 2 are be VBP cord-023584-yaxawqhj 280 3 five five CD cord-023584-yaxawqhj 280 4 main main JJ cord-023584-yaxawqhj 280 5 reasons reason NNS cord-023584-yaxawqhj 280 6 for for IN cord-023584-yaxawqhj 280 7 this this DT cord-023584-yaxawqhj 280 8 . . . cord-023584-yaxawqhj 281 1 First first RB cord-023584-yaxawqhj 281 2 , , , cord-023584-yaxawqhj 281 3 a a DT cord-023584-yaxawqhj 281 4 relatively relatively RB cord-023584-yaxawqhj 281 5 benign benign JJ cord-023584-yaxawqhj 281 6 human human JJ cord-023584-yaxawqhj 281 7 virus virus NN cord-023584-yaxawqhj 281 8 infection infection NN cord-023584-yaxawqhj 281 9 will will MD cord-023584-yaxawqhj 281 10 often often RB cord-023584-yaxawqhj 281 11 follow follow VB cord-023584-yaxawqhj 281 12 a a DT cord-023584-yaxawqhj 281 13 very very RB cord-023584-yaxawqhj 281 14 different different JJ cord-023584-yaxawqhj 281 15 , , , cord-023584-yaxawqhj 281 16 and and CC cord-023584-yaxawqhj 281 17 often often RB cord-023584-yaxawqhj 281 18 severe severe JJ cord-023584-yaxawqhj 281 19 course course NN cord-023584-yaxawqhj 281 20 in in IN cord-023584-yaxawqhj 281 21 an an DT cord-023584-yaxawqhj 281 22 animal animal NN cord-023584-yaxawqhj 281 23 . . . cord-023584-yaxawqhj 282 1 For for IN cord-023584-yaxawqhj 282 2 example example NN cord-023584-yaxawqhj 282 3 , , , cord-023584-yaxawqhj 282 4 influenza influenza NN cord-023584-yaxawqhj 282 5 virus virus NN cord-023584-yaxawqhj 282 6 , , , cord-023584-yaxawqhj 282 7 herpes herpes NN cord-023584-yaxawqhj 282 8 simplex simplex NN cord-023584-yaxawqhj 282 9 , , , cord-023584-yaxawqhj 282 10 and and CC cord-023584-yaxawqhj 282 11 coxsackie coxsackie NN cord-023584-yaxawqhj 282 12 viruses virus NNS cord-023584-yaxawqhj 282 13 may may MD cord-023584-yaxawqhj 282 14 cause cause VB cord-023584-yaxawqhj 282 15 much much RB cord-023584-yaxawqhj 282 16 more more RBR cord-023584-yaxawqhj 282 17 serious serious JJ cord-023584-yaxawqhj 282 18 diseases disease NNS cord-023584-yaxawqhj 282 19 in in IN cord-023584-yaxawqhj 282 20 laboratory laboratory NN cord-023584-yaxawqhj 282 21 animals animal NNS cord-023584-yaxawqhj 282 22 than than IN cord-023584-yaxawqhj 282 23 they -PRON- PRP cord-023584-yaxawqhj 282 24 do do VBP cord-023584-yaxawqhj 282 25 in in IN cord-023584-yaxawqhj 282 26 man man NN cord-023584-yaxawqhj 282 27 . . . cord-023584-yaxawqhj 283 1 Second second JJ cord-023584-yaxawqhj 283 2 , , , cord-023584-yaxawqhj 283 3 human human JJ cord-023584-yaxawqhj 283 4 viruses virus NNS cord-023584-yaxawqhj 283 5 often often RB cord-023584-yaxawqhj 283 6 must must MD cord-023584-yaxawqhj 283 7 be be VB cord-023584-yaxawqhj 283 8 adapted adapt VBN cord-023584-yaxawqhj 283 9 by by IN cord-023584-yaxawqhj 283 10 multiple multiple JJ cord-023584-yaxawqhj 283 11 passaging passaging NN cord-023584-yaxawqhj 283 12 before before IN cord-023584-yaxawqhj 283 13 they -PRON- PRP cord-023584-yaxawqhj 283 14 will will MD cord-023584-yaxawqhj 283 15 grow grow VB cord-023584-yaxawqhj 283 16 satisfactorily satisfactorily RB cord-023584-yaxawqhj 283 17 in in IN cord-023584-yaxawqhj 283 18 animal animal NN cord-023584-yaxawqhj 283 19 hosts host NNS cord-023584-yaxawqhj 283 20 , , , cord-023584-yaxawqhj 283 21 and and CC cord-023584-yaxawqhj 283 22 , , , cord-023584-yaxawqhj 283 23 therefore therefore RB cord-023584-yaxawqhj 283 24 , , , cord-023584-yaxawqhj 283 25 the the DT cord-023584-yaxawqhj 283 26 challenge challenge NN cord-023584-yaxawqhj 283 27 virus virus NN cord-023584-yaxawqhj 283 28 in in IN cord-023584-yaxawqhj 283 29 the the DT cord-023584-yaxawqhj 283 30 animal animal NN cord-023584-yaxawqhj 283 31 model model NN cord-023584-yaxawqhj 283 32 may may MD cord-023584-yaxawqhj 283 33 be be VB cord-023584-yaxawqhj 283 34 a a DT cord-023584-yaxawqhj 283 35 very very RB cord-023584-yaxawqhj 283 36 different different JJ cord-023584-yaxawqhj 283 37 creature creature NN cord-023584-yaxawqhj 283 38 from from IN cord-023584-yaxawqhj 283 39 the the DT cord-023584-yaxawqhj 283 40 original original JJ cord-023584-yaxawqhj 283 41 human human JJ cord-023584-yaxawqhj 283 42 pathogen pathogen NN cord-023584-yaxawqhj 283 43 . . . cord-023584-yaxawqhj 284 1 Third third RB cord-023584-yaxawqhj 284 2 , , , cord-023584-yaxawqhj 284 3 the the DT cord-023584-yaxawqhj 284 4 quantity quantity NN cord-023584-yaxawqhj 284 5 of of IN cord-023584-yaxawqhj 284 6 virus virus NN cord-023584-yaxawqhj 284 7 administered administer VBN cord-023584-yaxawqhj 284 8 to to IN cord-023584-yaxawqhj 284 9 an an DT cord-023584-yaxawqhj 284 10 animal animal NN cord-023584-yaxawqhj 284 11 in in IN cord-023584-yaxawqhj 284 12 order order NN cord-023584-yaxawqhj 284 13 to to TO cord-023584-yaxawqhj 284 14 produce produce VB cord-023584-yaxawqhj 284 15 some some DT cord-023584-yaxawqhj 284 16 measurable measurable JJ cord-023584-yaxawqhj 284 17 effect effect NN cord-023584-yaxawqhj 284 18 , , , cord-023584-yaxawqhj 284 19 e.g. e.g. RB cord-023584-yaxawqhj 284 20 , , , cord-023584-yaxawqhj 284 21 symptoms symptom NNS cord-023584-yaxawqhj 284 22 , , , cord-023584-yaxawqhj 284 23 virus virus NN cord-023584-yaxawqhj 284 24 isolation isolation NN cord-023584-yaxawqhj 284 25 , , , cord-023584-yaxawqhj 284 26 and and CC cord-023584-yaxawqhj 284 27 seroconversion seroconversion NN cord-023584-yaxawqhj 284 28 , , , cord-023584-yaxawqhj 284 29 is be VBZ cord-023584-yaxawqhj 284 30 usually usually RB cord-023584-yaxawqhj 284 31 vastly vastly RB cord-023584-yaxawqhj 284 32 greater great JJR cord-023584-yaxawqhj 284 33 than than IN cord-023584-yaxawqhj 284 34 would would MD cord-023584-yaxawqhj 284 35 ordinarily ordinarily RB cord-023584-yaxawqhj 284 36 be be VB cord-023584-yaxawqhj 284 37 encountered encounter VBN cord-023584-yaxawqhj 284 38 by by IN cord-023584-yaxawqhj 284 39 the the DT cord-023584-yaxawqhj 284 40 natural natural JJ cord-023584-yaxawqhj 284 41 host host NN cord-023584-yaxawqhj 284 42 , , , cord-023584-yaxawqhj 284 43 and and CC cord-023584-yaxawqhj 284 44 this this DT cord-023584-yaxawqhj 284 45 can can MD cord-023584-yaxawqhj 284 46 have have VB cord-023584-yaxawqhj 284 47 a a DT cord-023584-yaxawqhj 284 48 profound profound JJ cord-023584-yaxawqhj 284 49 bearing bearing NN cord-023584-yaxawqhj 284 50 on on IN cord-023584-yaxawqhj 284 51 the the DT cord-023584-yaxawqhj 284 52 efficacy efficacy NN cord-023584-yaxawqhj 284 53 of of IN cord-023584-yaxawqhj 284 54 any any DT cord-023584-yaxawqhj 284 55 curative curative JJ cord-023584-yaxawqhj 284 56 agent agent NN cord-023584-yaxawqhj 284 57 . . . cord-023584-yaxawqhj 285 1 For for IN cord-023584-yaxawqhj 285 2 example example NN cord-023584-yaxawqhj 285 3 , , , cord-023584-yaxawqhj 285 4 Finter Finter NNP cord-023584-yaxawqhj 285 5 ( ( -LRB- cord-023584-yaxawqhj 285 6 1967 1967 CD cord-023584-yaxawqhj 285 7 ) ) -RRB- cord-023584-yaxawqhj 285 8 has have VBZ cord-023584-yaxawqhj 285 9 shown show VBN cord-023584-yaxawqhj 285 10 that that IN cord-023584-yaxawqhj 285 11 the the DT cord-023584-yaxawqhj 285 12 protection protection NN cord-023584-yaxawqhj 285 13 offered offer VBN cord-023584-yaxawqhj 285 14 to to IN cord-023584-yaxawqhj 285 15 mice mouse NNS cord-023584-yaxawqhj 285 16 by by IN cord-023584-yaxawqhj 285 17 doses dose NNS cord-023584-yaxawqhj 285 18 of of IN cord-023584-yaxawqhj 285 19 interferon interferon NN cord-023584-yaxawqhj 285 20 is be VBZ cord-023584-yaxawqhj 285 21 greatly greatly RB cord-023584-yaxawqhj 285 22 increased increase VBN cord-023584-yaxawqhj 285 23 as as IN cord-023584-yaxawqhj 285 24 the the DT cord-023584-yaxawqhj 285 25 quantity quantity NN cord-023584-yaxawqhj 285 26 of of IN cord-023584-yaxawqhj 285 27 challenge challenge NN cord-023584-yaxawqhj 285 28 virus virus NN cord-023584-yaxawqhj 285 29 is be VBZ cord-023584-yaxawqhj 285 30 reduced reduce VBN cord-023584-yaxawqhj 285 31 . . . cord-023584-yaxawqhj 286 1 Fourth fourth RB cord-023584-yaxawqhj 286 2 , , , cord-023584-yaxawqhj 286 3 the the DT cord-023584-yaxawqhj 286 4 fate fate NN cord-023584-yaxawqhj 286 5 of of IN cord-023584-yaxawqhj 286 6 a a DT cord-023584-yaxawqhj 286 7 drug drug NN cord-023584-yaxawqhj 286 8 when when WRB cord-023584-yaxawqhj 286 9 administered administer VBN cord-023584-yaxawqhj 286 10 t t NNP cord-023584-yaxawqhj 286 11 o o NN cord-023584-yaxawqhj 286 12 an an DT cord-023584-yaxawqhj 286 13 animal animal NN cord-023584-yaxawqhj 286 14 may may MD cord-023584-yaxawqhj 286 15 be be VB cord-023584-yaxawqhj 286 16 very very RB cord-023584-yaxawqhj 286 17 different different JJ cord-023584-yaxawqhj 286 18 from from IN cord-023584-yaxawqhj 286 19 that that DT cord-023584-yaxawqhj 286 20 seen see VBN cord-023584-yaxawqhj 286 21 in in IN cord-023584-yaxawqhj 286 22 man man NN cord-023584-yaxawqhj 286 23 . . . cord-023584-yaxawqhj 287 1 And and CC cord-023584-yaxawqhj 287 2 last last JJ cord-023584-yaxawqhj 287 3 , , , cord-023584-yaxawqhj 287 4 a a DT cord-023584-yaxawqhj 287 5 compound compound NN cord-023584-yaxawqhj 287 6 may may MD cord-023584-yaxawqhj 287 7 show show VB cord-023584-yaxawqhj 287 8 toxio toxio JJ cord-023584-yaxawqhj 287 9 effects effect NNS cord-023584-yaxawqhj 287 10 in in IN cord-023584-yaxawqhj 287 11 man man NN cord-023584-yaxawqhj 287 12 which which WDT cord-023584-yaxawqhj 287 13 it -PRON- PRP cord-023584-yaxawqhj 287 14 did do VBD cord-023584-yaxawqhj 287 15 not not RB cord-023584-yaxawqhj 287 16 show show VB cord-023584-yaxawqhj 287 17 in in IN cord-023584-yaxawqhj 287 18 animals animal NNS cord-023584-yaxawqhj 287 19 . . . cord-023584-yaxawqhj 288 1 The the DT cord-023584-yaxawqhj 288 2 last last JJ cord-023584-yaxawqhj 288 3 two two CD cord-023584-yaxawqhj 288 4 points point NNS cord-023584-yaxawqhj 288 5 are be VBP cord-023584-yaxawqhj 288 6 probably probably RB cord-023584-yaxawqhj 288 7 the the DT cord-023584-yaxawqhj 288 8 most most RBS cord-023584-yaxawqhj 288 9 important important JJ cord-023584-yaxawqhj 288 10 in in IN cord-023584-yaxawqhj 288 11 determining determine VBG cord-023584-yaxawqhj 288 12 how how WRB cord-023584-yaxawqhj 288 13 far far RB cord-023584-yaxawqhj 288 14 the the DT cord-023584-yaxawqhj 288 15 results result NNS cord-023584-yaxawqhj 288 16 obtained obtain VBN cord-023584-yaxawqhj 288 17 with with IN cord-023584-yaxawqhj 288 18 animal animal NN cord-023584-yaxawqhj 288 19 models model NNS cord-023584-yaxawqhj 288 20 are be VBP cord-023584-yaxawqhj 288 21 relevant relevant JJ cord-023584-yaxawqhj 288 22 to to IN cord-023584-yaxawqhj 288 23 man man NN cord-023584-yaxawqhj 288 24 . . . cord-023584-yaxawqhj 289 1 In in IN cord-023584-yaxawqhj 289 2 theory theory NN cord-023584-yaxawqhj 289 3 the the DT cord-023584-yaxawqhj 289 4 above above JJ cord-023584-yaxawqhj 289 5 considerations consideration NNS cord-023584-yaxawqhj 289 6 should should MD cord-023584-yaxawqhj 289 7 operate operate VB cord-023584-yaxawqhj 289 8 in in IN cord-023584-yaxawqhj 289 9 both both DT cord-023584-yaxawqhj 289 10 directions direction NNS cord-023584-yaxawqhj 289 11 ; ; : cord-023584-yaxawqhj 289 12 that that RB cord-023584-yaxawqhj 289 13 is is RB cord-023584-yaxawqhj 289 14 , , , cord-023584-yaxawqhj 289 15 a a DT cord-023584-yaxawqhj 289 16 compound compound NN cord-023584-yaxawqhj 289 17 that that WDT cord-023584-yaxawqhj 289 18 shows show VBZ cord-023584-yaxawqhj 289 19 a a DT cord-023584-yaxawqhj 289 20 positive positive JJ cord-023584-yaxawqhj 289 21 result result NN cord-023584-yaxawqhj 289 22 in in IN cord-023584-yaxawqhj 289 23 an an DT cord-023584-yaxawqhj 289 24 animal animal NN cord-023584-yaxawqhj 289 25 model model NN cord-023584-yaxawqhj 289 26 may may MD cord-023584-yaxawqhj 289 27 be be VB cord-023584-yaxawqhj 289 28 positive positive JJ cord-023584-yaxawqhj 289 29 or or CC cord-023584-yaxawqhj 289 30 negative negative JJ cord-023584-yaxawqhj 289 31 in in IN cord-023584-yaxawqhj 289 32 man man NN cord-023584-yaxawqhj 289 33 , , , cord-023584-yaxawqhj 289 34 and and CC cord-023584-yaxawqhj 289 35 a a DT cord-023584-yaxawqhj 289 36 compound compound NN cord-023584-yaxawqhj 289 37 that that WDT cord-023584-yaxawqhj 289 38 is be VBZ cord-023584-yaxawqhj 289 39 negative negative JJ cord-023584-yaxawqhj 289 40 in in IN cord-023584-yaxawqhj 289 41 an an DT cord-023584-yaxawqhj 289 42 animal animal NN cord-023584-yaxawqhj 289 43 may may MD cord-023584-yaxawqhj 289 44 be be VB cord-023584-yaxawqhj 289 45 negative negative JJ cord-023584-yaxawqhj 289 46 or or CC cord-023584-yaxawqhj 289 47 positive positive JJ cord-023584-yaxawqhj 289 48 in in IN cord-023584-yaxawqhj 289 49 man man NN cord-023584-yaxawqhj 289 50 . . . cord-023584-yaxawqhj 290 1 But but CC cord-023584-yaxawqhj 290 2 , , , cord-023584-yaxawqhj 290 3 since since IN cord-023584-yaxawqhj 290 4 many many JJ cord-023584-yaxawqhj 290 5 animal animal NN cord-023584-yaxawqhj 290 6 models model NNS cord-023584-yaxawqhj 290 7 offer offer VBP cord-023584-yaxawqhj 290 8 a a DT cord-023584-yaxawqhj 290 9 greater great JJR cord-023584-yaxawqhj 290 10 challenge challenge NN cord-023584-yaxawqhj 290 11 to to IN cord-023584-yaxawqhj 290 12 the the DT cord-023584-yaxawqhj 290 13 therapeutic therapeutic JJ cord-023584-yaxawqhj 290 14 potential potential NN cord-023584-yaxawqhj 290 15 of of IN cord-023584-yaxawqhj 290 16 a a DT cord-023584-yaxawqhj 290 17 drug drug NN cord-023584-yaxawqhj 290 18 than than IN cord-023584-yaxawqhj 290 19 the the DT cord-023584-yaxawqhj 290 20 natural natural JJ cord-023584-yaxawqhj 290 21 disease disease NN cord-023584-yaxawqhj 290 22 in in IN cord-023584-yaxawqhj 290 23 man man NN cord-023584-yaxawqhj 290 24 , , , cord-023584-yaxawqhj 290 25 a a DT cord-023584-yaxawqhj 290 26 positive positive JJ cord-023584-yaxawqhj 290 27 result result NN cord-023584-yaxawqhj 290 28 in in IN cord-023584-yaxawqhj 290 29 an an DT cord-023584-yaxawqhj 290 30 animal animal NN cord-023584-yaxawqhj 290 31 model model NN cord-023584-yaxawqhj 290 32 always always RB cord-023584-yaxawqhj 290 33 gives give VBZ cord-023584-yaxawqhj 290 34 great great JJ cord-023584-yaxawqhj 290 35 hopes hope NNS cord-023584-yaxawqhj 290 36 that that IN cord-023584-yaxawqhj 290 37 a a DT cord-023584-yaxawqhj 290 38 positive positive JJ cord-023584-yaxawqhj 290 39 result result NN cord-023584-yaxawqhj 290 40 might may MD cord-023584-yaxawqhj 290 41 be be VB cord-023584-yaxawqhj 290 42 achieved achieve VBN cord-023584-yaxawqhj 290 43 in in IN cord-023584-yaxawqhj 290 44 man man NN cord-023584-yaxawqhj 290 45 . . . cord-023584-yaxawqhj 291 1 This this DT cord-023584-yaxawqhj 291 2 consideration consideration NN cord-023584-yaxawqhj 291 3 often often RB cord-023584-yaxawqhj 291 4 encourages encourage VBZ cord-023584-yaxawqhj 291 5 the the DT cord-023584-yaxawqhj 291 6 evaluation evaluation NN cord-023584-yaxawqhj 291 7 of of IN cord-023584-yaxawqhj 291 8 potential potential JJ cord-023584-yaxawqhj 291 9 antiviral antiviral JJ cord-023584-yaxawqhj 291 10 drugs drug NNS cord-023584-yaxawqhj 291 11 in in IN cord-023584-yaxawqhj 291 12 man man NN cord-023584-yaxawqhj 291 13 on on IN cord-023584-yaxawqhj 291 14 the the DT cord-023584-yaxawqhj 291 15 very very RB cord-023584-yaxawqhj 291 16 slimmest slim JJS cord-023584-yaxawqhj 291 17 of of IN cord-023584-yaxawqhj 291 18 grounds ground NNS cord-023584-yaxawqhj 291 19 . . . cord-023584-yaxawqhj 292 1 An an DT cord-023584-yaxawqhj 292 2 example example NN cord-023584-yaxawqhj 292 3 of of IN cord-023584-yaxawqhj 292 4 the the DT cord-023584-yaxawqhj 292 5 dilemma dilemma NN cord-023584-yaxawqhj 292 6 that that IN cord-023584-yaxawqhj 292 7 an an DT cord-023584-yaxawqhj 292 8 animal animal NN cord-023584-yaxawqhj 292 9 model model NN cord-023584-yaxawqhj 292 10 may may MD cord-023584-yaxawqhj 292 11 pose pose VB cord-023584-yaxawqhj 292 12 is be VBZ cord-023584-yaxawqhj 292 13 afforded afford VBN cord-023584-yaxawqhj 292 14 by by IN cord-023584-yaxawqhj 292 15 the the DT cord-023584-yaxawqhj 292 16 _SP cord-023584-yaxawqhj 292 17 ork ork NNP cord-023584-yaxawqhj 292 18 of of IN cord-023584-yaxawqhj 292 19 Boyle Boyle NNP cord-023584-yaxawqhj 292 20 and and CC cord-023584-yaxawqhj 292 21 his -PRON- PRP$ cord-023584-yaxawqhj 292 22 colleagues colleague NNS cord-023584-yaxawqhj 292 23 ( ( -LRB- cord-023584-yaxawqhj 292 24 1970 1970 CD cord-023584-yaxawqhj 292 25 ) ) -RRB- cord-023584-yaxawqhj 292 26 on on IN cord-023584-yaxawqhj 292 27 the the DT cord-023584-yaxawqhj 292 28 compound compound NN cord-023584-yaxawqhj 292 29 SKF SKF NNP cord-023584-yaxawqhj 292 30 30097 30097 CD cord-023584-yaxawqhj 292 31 . . . cord-023584-yaxawqhj 293 1 This this DT cord-023584-yaxawqhj 293 2 compound compound NN cord-023584-yaxawqhj 293 3 was be VBD cord-023584-yaxawqhj 293 4 shown show VBN cord-023584-yaxawqhj 293 5 to to TO cord-023584-yaxawqhj 293 6 be be VB cord-023584-yaxawqhj 293 7 active active JJ cord-023584-yaxawqhj 293 8 against against IN cord-023584-yaxawqhj 293 9 a a DT cord-023584-yaxawqhj 293 10 number number NN cord-023584-yaxawqhj 293 11 of of IN cord-023584-yaxawqhj 293 12 viruses virus NNS cord-023584-yaxawqhj 293 13 , , , cord-023584-yaxawqhj 293 14 including include VBG cord-023584-yaxawqhj 293 15 a a DT cord-023584-yaxawqhj 293 16 wide wide JJ cord-023584-yaxawqhj 293 17 range range NN cord-023584-yaxawqhj 293 18 of of IN cord-023584-yaxawqhj 293 19 human human JJ cord-023584-yaxawqhj 293 20 rhinoviruses rhinovirus NNS cord-023584-yaxawqhj 293 21 , , , cord-023584-yaxawqhj 293 22 in in IN cord-023584-yaxawqhj 293 23 tissue tissue NN cord-023584-yaxawqhj 293 24 culture culture NN cord-023584-yaxawqhj 293 25 . . . cord-023584-yaxawqhj 294 1 The the DT cord-023584-yaxawqhj 294 2 problem problem NN cord-023584-yaxawqhj 294 3 arose arise VBD cord-023584-yaxawqhj 294 4 of of IN cord-023584-yaxawqhj 294 5 how how WRB cord-023584-yaxawqhj 294 6 to to TO cord-023584-yaxawqhj 294 7 evaluate evaluate VB cord-023584-yaxawqhj 294 8 this this DT cord-023584-yaxawqhj 294 9 compound compound NN cord-023584-yaxawqhj 294 10 in in IN cord-023584-yaxawqhj 294 11 vivo vivo NN cord-023584-yaxawqhj 294 12 . . . cord-023584-yaxawqhj 295 1 There there EX cord-023584-yaxawqhj 295 2 are be VBP cord-023584-yaxawqhj 295 3 no no DT cord-023584-yaxawqhj 295 4 smallanimal smallanimal NNP cord-023584-yaxawqhj 295 5 modrls modrls NNP cord-023584-yaxawqhj 295 6 of of IN cord-023584-yaxawqhj 295 7 human human JJ cord-023584-yaxawqhj 295 8 rhinovirus rhinovirus NN cord-023584-yaxawqhj 295 9 infections infection NNS cord-023584-yaxawqhj 295 10 , , , cord-023584-yaxawqhj 295 11 and and CC cord-023584-yaxawqhj 295 12 the the DT cord-023584-yaxawqhj 295 13 authors author NNS cord-023584-yaxawqhj 295 14 , , , cord-023584-yaxawqhj 295 15 therefore therefore RB cord-023584-yaxawqhj 295 16 , , , cord-023584-yaxawqhj 295 17 decided decide VBD cord-023584-yaxawqhj 295 18 to to TO cord-023584-yaxawqhj 295 19 test test VB cord-023584-yaxawqhj 295 20 the the DT cord-023584-yaxawqhj 295 21 compound compound NN cord-023584-yaxawqhj 295 22 in in IN cord-023584-yaxawqhj 295 23 chimpanzees chimpanzee NNS cord-023584-yaxawqhj 295 24 , , , cord-023584-yaxawqhj 295 25 which which WDT cord-023584-yaxawqhj 295 26 are be VBP cord-023584-yaxawqhj 295 27 one one CD cord-023584-yaxawqhj 295 28 of of IN cord-023584-yaxawqhj 295 29 the the DT cord-023584-yaxawqhj 295 30 few few JJ cord-023584-yaxawqhj 295 31 primates primate NNS cord-023584-yaxawqhj 295 32 susceptible susceptible JJ cord-023584-yaxawqhj 295 33 to to IN cord-023584-yaxawqhj 295 34 human human JJ cord-023584-yaxawqhj 295 35 rhinoviruses rhinovirus NNS cord-023584-yaxawqhj 295 36 . . . cord-023584-yaxawqhj 296 1 Because because IN cord-023584-yaxawqhj 296 2 of of IN cord-023584-yaxawqhj 296 3 lack lack NN cord-023584-yaxawqhj 296 4 of of IN cord-023584-yaxawqhj 296 5 knowledge knowledge NN cord-023584-yaxawqhj 296 6 on on IN cord-023584-yaxawqhj 296 7 infectivity infectivity NN cord-023584-yaxawqhj 296 8 of of IN cord-023584-yaxawqhj 296 9 human human JJ cord-023584-yaxawqhj 296 10 rhinoviruses rhinovirus NNS cord-023584-yaxawqhj 296 11 for for IN cord-023584-yaxawqhj 296 12 chimpanzees chimpanzee NNS cord-023584-yaxawqhj 296 13 , , , cord-023584-yaxawqhj 296 14 the the DT cord-023584-yaxawqhj 296 15 authors author NNS cord-023584-yaxawqhj 296 16 gave give VBD cord-023584-yaxawqhj 296 17 up up RP cord-023584-yaxawqhj 296 18 to to TO cord-023584-yaxawqhj 296 19 10 10 CD cord-023584-yaxawqhj 296 20 , , , cord-023584-yaxawqhj 296 21 OOO OOO NNP cord-023584-yaxawqhj 296 22 TCD TCD NNP cord-023584-yaxawqhj 296 23 , , , cord-023584-yaxawqhj 296 24 , , , cord-023584-yaxawqhj 296 25 of of IN cord-023584-yaxawqhj 296 26 challenge challenge NN cord-023584-yaxawqhj 296 27 virus virus NN cord-023584-yaxawqhj 296 28 to to IN cord-023584-yaxawqhj 296 29 each each DT cord-023584-yaxawqhj 296 30 animal animal NN cord-023584-yaxawqhj 296 31 to to IN cord-023584-yaxawqhj 296 32 ensurc ensurc NNP cord-023584-yaxawqhj 296 33 infcction infcction NN cord-023584-yaxawqhj 296 34 . . . cord-023584-yaxawqhj 297 1 The the DT cord-023584-yaxawqhj 297 2 animals animal NNS cord-023584-yaxawqhj 297 3 were be VBD cord-023584-yaxawqhj 297 4 given give VBN cord-023584-yaxawqhj 297 5 the the DT cord-023584-yaxawqhj 297 6 drug drug NN cord-023584-yaxawqhj 297 7 orally orally RB cord-023584-yaxawqhj 297 8 3 3 CD cord-023584-yaxawqhj 297 9 times time NNS cord-023584-yaxawqhj 297 10 a a DT cord-023584-yaxawqhj 297 11 day day NN cord-023584-yaxawqhj 297 12 , , , cord-023584-yaxawqhj 297 13 and and CC cord-023584-yaxawqhj 297 14 the the DT cord-023584-yaxawqhj 297 15 course course NN cord-023584-yaxawqhj 297 16 of of IN cord-023584-yaxawqhj 297 17 the the DT cord-023584-yaxawqhj 297 18 disease disease NN cord-023584-yaxawqhj 297 19 was be VBD cord-023584-yaxawqhj 297 20 monitored monitor VBN cord-023584-yaxawqhj 297 21 by by IN cord-023584-yaxawqhj 297 22 virus virus NN cord-023584-yaxawqhj 297 23 shedding shed VBG cord-023584-yaxawqhj 297 24 from from IN cord-023584-yaxawqhj 297 25 the the DT cord-023584-yaxawqhj 297 26 nose nose NN cord-023584-yaxawqhj 297 27 . . . cord-023584-yaxawqhj 298 1 The the DT cord-023584-yaxawqhj 298 2 rate rate NN cord-023584-yaxawqhj 298 3 of of IN cord-023584-yaxawqhj 298 4 antibody antibody NN cord-023584-yaxawqhj 298 5 rise rise NN cord-023584-yaxawqhj 298 6 was be VBD cord-023584-yaxawqhj 298 7 also also RB cord-023584-yaxawqhj 298 8 measured measure VBN cord-023584-yaxawqhj 298 9 . . . cord-023584-yaxawqhj 299 1 The the DT cord-023584-yaxawqhj 299 2 numbers number NNS cord-023584-yaxawqhj 299 3 of of IN cord-023584-yaxawqhj 299 4 animals animal NNS cord-023584-yaxawqhj 299 5 in in IN cord-023584-yaxawqhj 299 6 each each DT cord-023584-yaxawqhj 299 7 experiment experiment NN cord-023584-yaxawqhj 299 8 were be VBD cord-023584-yaxawqhj 299 9 necessarily necessarily RB cord-023584-yaxawqhj 299 10 small small JJ cord-023584-yaxawqhj 299 11 - - : cord-023584-yaxawqhj 299 12 usually usually RB cord-023584-yaxawqhj 299 13 2 2 CD cord-023584-yaxawqhj 299 14 or or CC cord-023584-yaxawqhj 299 15 3 3 CD cord-023584-yaxawqhj 299 16 treated treat VBN cord-023584-yaxawqhj 299 17 with with IN cord-023584-yaxawqhj 299 18 drug drug NN cord-023584-yaxawqhj 299 19 and and CC cord-023584-yaxawqhj 299 20 2 2 CD cord-023584-yaxawqhj 299 21 or or CC cord-023584-yaxawqhj 299 22 3 3 CD cord-023584-yaxawqhj 299 23 controls control NNS cord-023584-yaxawqhj 299 24 . . . cord-023584-yaxawqhj 300 1 The the DT cord-023584-yaxawqhj 300 2 final final JJ cord-023584-yaxawqhj 300 3 results result NNS cord-023584-yaxawqhj 300 4 were be VBD cord-023584-yaxawqhj 300 5 tantalizingly tantalizingly RB cord-023584-yaxawqhj 300 6 inconclusive inconclusive JJ cord-023584-yaxawqhj 300 7 : : : cord-023584-yaxawqhj 300 8 not not RB cord-023584-yaxawqhj 300 9 clearly clearly RB cord-023584-yaxawqhj 300 10 negative negative JJ cord-023584-yaxawqhj 300 11 , , , cord-023584-yaxawqhj 300 12 nor nor CC cord-023584-yaxawqhj 300 13 convincingly convincingly RB cord-023584-yaxawqhj 300 14 positive positive JJ cord-023584-yaxawqhj 300 15 that that IN cord-023584-yaxawqhj 300 16 the the DT cord-023584-yaxawqhj 300 17 drug drug NN cord-023584-yaxawqhj 300 18 had have VBD cord-023584-yaxawqhj 300 19 produced produce VBN cord-023584-yaxawqhj 300 20 a a DT cord-023584-yaxawqhj 300 21 curative curative JJ cord-023584-yaxawqhj 300 22 effect effect NN cord-023584-yaxawqhj 300 23 . . . cord-023584-yaxawqhj 301 1 The the DT cord-023584-yaxawqhj 301 2 investigators investigator NNS cord-023584-yaxawqhj 301 3 admit admit VBP cord-023584-yaxawqhj 301 4 that that IN cord-023584-yaxawqhj 301 5 this this DT cord-023584-yaxawqhj 301 6 system system NN cord-023584-yaxawqhj 301 7 is be VBZ cord-023584-yaxawqhj 301 8 far far RB cord-023584-yaxawqhj 301 9 from from IN cord-023584-yaxawqhj 301 10 satisfactory satisfactory JJ cord-023584-yaxawqhj 301 11 but but CC cord-023584-yaxawqhj 301 12 conclude conclude VB cord-023584-yaxawqhj 301 13 from from IN cord-023584-yaxawqhj 301 14 their -PRON- PRP$ cord-023584-yaxawqhj 301 15 results result NNS cord-023584-yaxawqhj 301 16 that that IN cord-023584-yaxawqhj 301 17 the the DT cord-023584-yaxawqhj 301 18 compound compound NN cord-023584-yaxawqhj 301 19 is be VBZ cord-023584-yaxawqhj 301 20 n n JJ cord-023584-yaxawqhj 301 21 - - HYPH cord-023584-yaxawqhj 301 22 orthwhile orthwhile NN cord-023584-yaxawqhj 301 23 studying study VBG cord-023584-yaxawqhj 301 24 further far RBR cord-023584-yaxawqhj 301 25 in in IN cord-023584-yaxawqhj 301 26 human human JJ cord-023584-yaxawqhj 301 27 subjects subject NNS cord-023584-yaxawqhj 301 28 . . . cord-023584-yaxawqhj 302 1 The the DT cord-023584-yaxawqhj 302 2 same same JJ cord-023584-yaxawqhj 302 3 conclusion conclusion NN cord-023584-yaxawqhj 302 4 , , , cord-023584-yaxawqhj 302 5 however however RB cord-023584-yaxawqhj 302 6 , , , cord-023584-yaxawqhj 302 7 would would MD cord-023584-yaxawqhj 302 8 probably probably RB cord-023584-yaxawqhj 302 9 have have VB cord-023584-yaxawqhj 302 10 been be VBN cord-023584-yaxawqhj 302 11 reached reach VBN cord-023584-yaxawqhj 302 12 if if IN cord-023584-yaxawqhj 302 13 the the DT cord-023584-yaxawqhj 302 14 compound compound NN cord-023584-yaxawqhj 302 15 had have VBD cord-023584-yaxawqhj 302 16 been be VBN cord-023584-yaxawqhj 302 17 clearly clearly RB cord-023584-yaxawqhj 302 18 inactive inactive JJ cord-023584-yaxawqhj 302 19 in in IN cord-023584-yaxawqhj 302 20 the the DT cord-023584-yaxawqhj 302 21 chimpanzees chimpanzee NNS cord-023584-yaxawqhj 302 22 , , , cord-023584-yaxawqhj 302 23 on on IN cord-023584-yaxawqhj 302 24 the the DT cord-023584-yaxawqhj 302 25 grounds ground NNS cord-023584-yaxawqhj 302 26 that that IN cord-023584-yaxawqhj 302 27 the the DT cord-023584-yaxawqhj 302 28 excessive excessive JJ cord-023584-yaxawqhj 302 29 doses dose NNS cord-023584-yaxawqhj 302 30 of of IN cord-023584-yaxawqhj 302 31 challenge challenge NN cord-023584-yaxawqhj 302 32 virus virus NN cord-023584-yaxawqhj 302 33 and and CC cord-023584-yaxawqhj 302 34 unknown unknown JJ cord-023584-yaxawqhj 302 35 factors factor NNS cord-023584-yaxawqhj 302 36 in in IN cord-023584-yaxawqhj 302 37 the the DT cord-023584-yaxawqhj 302 38 chimpanzee chimpanzee NN cord-023584-yaxawqhj 302 39 metabolism metabolism NN cord-023584-yaxawqhj 302 40 could could MD cord-023584-yaxawqhj 302 41 have have VB cord-023584-yaxawqhj 302 42 led lead VBN cord-023584-yaxawqhj 302 43 to to IN cord-023584-yaxawqhj 302 44 this this DT cord-023584-yaxawqhj 302 45 result result NN cord-023584-yaxawqhj 302 46 . . . cord-023584-yaxawqhj 303 1 Animal animal NN cord-023584-yaxawqhj 303 2 models model NNS cord-023584-yaxawqhj 303 3 of of IN cord-023584-yaxawqhj 303 4 human human JJ cord-023584-yaxawqhj 303 5 virus virus NN cord-023584-yaxawqhj 303 6 disease disease NN cord-023584-yaxawqhj 303 7 must must MD cord-023584-yaxawqhj 303 8 at at IN cord-023584-yaxawqhj 303 9 best well RBS cord-023584-yaxawqhj 303 10 be be VB cord-023584-yaxawqhj 303 11 regarded regard VBN cord-023584-yaxawqhj 303 12 as as IN cord-023584-yaxawqhj 303 13 poor poor JJ cord-023584-yaxawqhj 303 14 imitations imitation NNS cord-023584-yaxawqhj 303 15 of of IN cord-023584-yaxawqhj 303 16 the the DT cord-023584-yaxawqhj 303 17 natural natural JJ cord-023584-yaxawqhj 303 18 condition condition NN cord-023584-yaxawqhj 303 19 , , , cord-023584-yaxawqhj 303 20 and and CC cord-023584-yaxawqhj 303 21 results result NNS cord-023584-yaxawqhj 303 22 obtained obtain VBN cord-023584-yaxawqhj 303 23 with with IN cord-023584-yaxawqhj 303 24 animal animal NN cord-023584-yaxawqhj 303 25 models model NNS cord-023584-yaxawqhj 303 26 , , , cord-023584-yaxawqhj 303 27 whether whether IN cord-023584-yaxawqhj 303 28 they -PRON- PRP cord-023584-yaxawqhj 303 29 are be VBP cord-023584-yaxawqhj 303 30 positive positive JJ cord-023584-yaxawqhj 303 31 or or CC cord-023584-yaxawqhj 303 32 negative negative JJ cord-023584-yaxawqhj 303 33 , , , cord-023584-yaxawqhj 303 34 encouraging encouraging JJ cord-023584-yaxawqhj 303 35 or or CC cord-023584-yaxawqhj 303 36 discouraging discouraging JJ cord-023584-yaxawqhj 303 37 , , , cord-023584-yaxawqhj 303 38 should should MD cord-023584-yaxawqhj 303 39 be be VB cord-023584-yaxawqhj 303 40 interprcted interprcte VBN cord-023584-yaxawqhj 303 41 cautiously cautiously RB cord-023584-yaxawqhj 303 42 and and CC cord-023584-yaxawqhj 303 43 never never RB cord-023584-yaxawqhj 303 44 be be VB cord-023584-yaxawqhj 303 45 used use VBN cord-023584-yaxawqhj 303 46 as as IN cord-023584-yaxawqhj 303 47 the the DT cord-023584-yaxawqhj 303 48 sole sole JJ cord-023584-yaxawqhj 303 49 basis basis NN cord-023584-yaxawqhj 303 50 for for IN cord-023584-yaxawqhj 303 51 predicting predict VBG cord-023584-yaxawqhj 303 52 the the DT cord-023584-yaxawqhj 303 53 outcome outcome NN cord-023584-yaxawqhj 303 54 in in IN cord-023584-yaxawqhj 303 55 man man NN cord-023584-yaxawqhj 303 56 . . . cord-023584-yaxawqhj 304 1 Research research NN cord-023584-yaxawqhj 304 2 into into IN cord-023584-yaxawqhj 304 3 the the DT cord-023584-yaxawqhj 304 4 treatment treatment NN cord-023584-yaxawqhj 304 5 of of IN cord-023584-yaxawqhj 304 6 virus virus NN cord-023584-yaxawqhj 304 7 diseases disease NNS cord-023584-yaxawqhj 304 8 by by IN cord-023584-yaxawqhj 304 9 drugs drug NNS cord-023584-yaxawqhj 304 10 is be VBZ cord-023584-yaxawqhj 304 11 a a DT cord-023584-yaxawqhj 304 12 t t NN cord-023584-yaxawqhj 304 13 present present NN cord-023584-yaxawqhj 304 14 directed direct VBN cord-023584-yaxawqhj 304 15 toward toward IN cord-023584-yaxawqhj 304 16 three three CD cord-023584-yaxawqhj 304 17 general general JJ cord-023584-yaxawqhj 304 18 areas area NNS cord-023584-yaxawqhj 304 19 : : : cord-023584-yaxawqhj 304 20 ( ( -LRB- cord-023584-yaxawqhj 304 21 1 1 LS cord-023584-yaxawqhj 304 22 ) ) -RRB- cord-023584-yaxawqhj 304 23 attempts attempt VBZ cord-023584-yaxawqhj 304 24 to to TO cord-023584-yaxawqhj 304 25 stimulate stimulate VB cord-023584-yaxawqhj 304 26 the the DT cord-023584-yaxawqhj 304 27 defense defense NN cord-023584-yaxawqhj 304 28 mechanism mechanism NN cord-023584-yaxawqhj 304 29 of of IN cord-023584-yaxawqhj 304 30 the the DT cord-023584-yaxawqhj 304 31 host host NN cord-023584-yaxawqhj 304 32 animal animal NN cord-023584-yaxawqhj 304 33 ; ; : cord-023584-yaxawqhj 304 34 ( ( -LRB- cord-023584-yaxawqhj 304 35 2 2 LS cord-023584-yaxawqhj 304 36 ) ) -RRB- cord-023584-yaxawqhj 304 37 large large JJ cord-023584-yaxawqhj 304 38 screening screening NN cord-023584-yaxawqhj 304 39 programs program NNS cord-023584-yaxawqhj 304 40 to to TO cord-023584-yaxawqhj 304 41 find find VB cord-023584-yaxawqhj 304 42 drugs drug NNS cord-023584-yaxawqhj 304 43 that that WDT cord-023584-yaxawqhj 304 44 directly directly RB cord-023584-yaxawqhj 304 45 block block VBP cord-023584-yaxawqhj 304 46 some some DT cord-023584-yaxawqhj 304 47 virus virus NN cord-023584-yaxawqhj 304 48 - - HYPH cord-023584-yaxawqhj 304 49 specific specific JJ cord-023584-yaxawqhj 304 50 process process NN cord-023584-yaxawqhj 304 51 ; ; : cord-023584-yaxawqhj 304 52 and and CC cord-023584-yaxawqhj 304 53 ( ( -LRB- cord-023584-yaxawqhj 304 54 3 3 LS cord-023584-yaxawqhj 304 55 ) ) -RRB- cord-023584-yaxawqhj 304 56 alleviation alleviation NN cord-023584-yaxawqhj 304 57 of of IN cord-023584-yaxawqhj 304 58 the the DT cord-023584-yaxawqhj 304 59 symptoms symptom NNS cord-023584-yaxawqhj 304 60 of of IN cord-023584-yaxawqhj 304 61 the the DT cord-023584-yaxawqhj 304 62 disease disease NN cord-023584-yaxawqhj 304 63 . . . cord-023584-yaxawqhj 305 1 The the DT cord-023584-yaxawqhj 305 2 first first JJ cord-023584-yaxawqhj 305 3 approach approach NN cord-023584-yaxawqhj 305 4 is be VBZ cord-023584-yaxawqhj 305 5 exemplified exemplify VBN cord-023584-yaxawqhj 305 6 by by IN cord-023584-yaxawqhj 305 7 the the DT cord-023584-yaxawqhj 305 8 variety variety NN cord-023584-yaxawqhj 305 9 of of IN cord-023584-yaxawqhj 305 10 interferon interferon NN cord-023584-yaxawqhj 305 11 inducers inducer NNS cord-023584-yaxawqhj 305 12 which which WDT cord-023584-yaxawqhj 305 13 are be VBP cord-023584-yaxawqhj 305 14 a a DT cord-023584-yaxawqhj 305 15 t t NN cord-023584-yaxawqhj 305 16 present present JJ cord-023584-yaxawqhj 305 17 under under IN cord-023584-yaxawqhj 305 18 intensive intensive JJ cord-023584-yaxawqhj 305 19 study study NN cord-023584-yaxawqhj 305 20 . . . cord-023584-yaxawqhj 306 1 A a DT cord-023584-yaxawqhj 306 2 disappointing disappointing JJ cord-023584-yaxawqhj 306 3 feature feature NN cord-023584-yaxawqhj 306 4 of of IN cord-023584-yaxawqhj 306 5 these these DT cord-023584-yaxawqhj 306 6 is be VBZ cord-023584-yaxawqhj 306 7 their -PRON- PRP$ cord-023584-yaxawqhj 306 8 uniformly uniformly RB cord-023584-yaxawqhj 306 9 low low JJ cord-023584-yaxawqhj 306 10 activity activity NN cord-023584-yaxawqhj 306 11 in in IN cord-023584-yaxawqhj 306 12 man man NN cord-023584-yaxawqhj 306 13 , , , cord-023584-yaxawqhj 306 14 despite despite IN cord-023584-yaxawqhj 306 15 highly highly RB cord-023584-yaxawqhj 306 16 promising promising JJ cord-023584-yaxawqhj 306 17 results result NNS cord-023584-yaxawqhj 306 18 in in IN cord-023584-yaxawqhj 306 19 laboratory laboratory NN cord-023584-yaxawqhj 306 20 animals animal NNS cord-023584-yaxawqhj 306 21 , , , cord-023584-yaxawqhj 306 22 such such JJ cord-023584-yaxawqhj 306 23 as as IN cord-023584-yaxawqhj 306 24 mice mouse NNS cord-023584-yaxawqhj 306 25 , , , cord-023584-yaxawqhj 306 26 rats rat NNS cord-023584-yaxawqhj 306 27 , , , cord-023584-yaxawqhj 306 28 and and CC cord-023584-yaxawqhj 306 29 rabbits rabbit NNS cord-023584-yaxawqhj 306 30 . . . cord-023584-yaxawqhj 307 1 Perhaps perhaps RB cord-023584-yaxawqhj 307 2 the the DT cord-023584-yaxawqhj 307 3 interferon interferon NN cord-023584-yaxawqhj 307 4 response response NN cord-023584-yaxawqhj 307 5 in in IN cord-023584-yaxawqhj 307 6 man man NN cord-023584-yaxawqhj 307 7 and and CC cord-023584-yaxawqhj 307 8 primates primate NNS cord-023584-yaxawqhj 307 9 is be VBZ cord-023584-yaxawqhj 307 10 less less RBR cord-023584-yaxawqhj 307 11 important important JJ cord-023584-yaxawqhj 307 12 in in IN cord-023584-yaxawqhj 307 13 defense defense NN cord-023584-yaxawqhj 307 14 against against IN cord-023584-yaxawqhj 307 15 virus virus NN cord-023584-yaxawqhj 307 16 disease disease NN cord-023584-yaxawqhj 307 17 than than IN cord-023584-yaxawqhj 307 18 it -PRON- PRP cord-023584-yaxawqhj 307 19 is be VBZ cord-023584-yaxawqhj 307 20 in in IN cord-023584-yaxawqhj 307 21 other other JJ cord-023584-yaxawqhj 307 22 taxonomic taxonomic JJ cord-023584-yaxawqhj 307 23 groups group NNS cord-023584-yaxawqhj 307 24 . . . cord-023584-yaxawqhj 308 1 Searches search NNS cord-023584-yaxawqhj 308 2 are be VBP cord-023584-yaxawqhj 308 3 being be VBG cord-023584-yaxawqhj 308 4 made make VBN cord-023584-yaxawqhj 308 5 for for IN cord-023584-yaxawqhj 308 6 more more JJR cord-023584-yaxawqhj 308 7 general general JJ cord-023584-yaxawqhj 308 8 stimulants stimulant NNS cord-023584-yaxawqhj 308 9 of of IN cord-023584-yaxawqhj 308 10 host host NN cord-023584-yaxawqhj 308 11 defense defense NN cord-023584-yaxawqhj 308 12 mechanisms mechanism NNS cord-023584-yaxawqhj 308 13 , , , cord-023584-yaxawqhj 308 14 for for IN cord-023584-yaxawqhj 308 15 example example NN cord-023584-yaxawqhj 308 16 , , , cord-023584-yaxawqhj 308 17 stimulators stimulator NNS cord-023584-yaxawqhj 308 18 of of IN cord-023584-yaxawqhj 308 19 phagocytosis phagocytosis NN cord-023584-yaxawqhj 308 20 and and CC cord-023584-yaxawqhj 308 21 the the DT cord-023584-yaxawqhj 308 22 immune immune JJ cord-023584-yaxawqhj 308 23 response response NN cord-023584-yaxawqhj 308 24 , , , cord-023584-yaxawqhj 308 25 but but CC cord-023584-yaxawqhj 308 26 very very RB cord-023584-yaxawqhj 308 27 little little JJ cord-023584-yaxawqhj 308 28 progress progress NN cord-023584-yaxawqhj 308 29 has have VBZ cord-023584-yaxawqhj 308 30 been be VBN cord-023584-yaxawqhj 308 31 reported report VBN cord-023584-yaxawqhj 308 32 so so RB cord-023584-yaxawqhj 308 33 far far RB cord-023584-yaxawqhj 308 34 . . . cord-023584-yaxawqhj 309 1 The the DT cord-023584-yaxawqhj 309 2 search search NN cord-023584-yaxawqhj 309 3 for for IN cord-023584-yaxawqhj 309 4 drugs drug NNS cord-023584-yaxawqhj 309 5 that that WDT cord-023584-yaxawqhj 309 6 will will MD cord-023584-yaxawqhj 309 7 directly directly RB cord-023584-yaxawqhj 309 8 inhibit inhibit VB cord-023584-yaxawqhj 309 9 virus virus NN cord-023584-yaxawqhj 309 10 replication replication NN cord-023584-yaxawqhj 309 11 , , , cord-023584-yaxawqhj 309 12 by by IN cord-023584-yaxawqhj 309 13 stopping stop VBG cord-023584-yaxawqhj 309 14 a a DT cord-023584-yaxawqhj 309 15 virus virus NN cord-023584-yaxawqhj 309 16 - - HYPH cord-023584-yaxawqhj 309 17 coded code VBN cord-023584-yaxawqhj 309 18 synthetic synthetic JJ cord-023584-yaxawqhj 309 19 process process NN cord-023584-yaxawqhj 309 20 , , , cord-023584-yaxawqhj 309 21 or or CC cord-023584-yaxawqhj 309 22 the the DT cord-023584-yaxawqhj 309 23 absorption absorption NN cord-023584-yaxawqhj 309 24 , , , cord-023584-yaxawqhj 309 25 penetration penetration NN cord-023584-yaxawqhj 309 26 , , , cord-023584-yaxawqhj 309 27 uncoating uncoating NN cord-023584-yaxawqhj 309 28 , , , cord-023584-yaxawqhj 309 29 assembly assembly NN cord-023584-yaxawqhj 309 30 , , , cord-023584-yaxawqhj 309 31 or or CC cord-023584-yaxawqhj 309 32 release release NN cord-023584-yaxawqhj 309 33 of of IN cord-023584-yaxawqhj 309 34 virions virion NNS cord-023584-yaxawqhj 309 35 , , , cord-023584-yaxawqhj 309 36 has have VBZ cord-023584-yaxawqhj 309 37 been be VBN cord-023584-yaxawqhj 309 38 intensive intensive JJ cord-023584-yaxawqhj 309 39 and and CC cord-023584-yaxawqhj 309 40 is be VBZ cord-023584-yaxawqhj 309 41 still still RB cord-023584-yaxawqhj 309 42 continuing continue VBG cord-023584-yaxawqhj 309 43 . . . cord-023584-yaxawqhj 310 1 Nevertheless nevertheless RB cord-023584-yaxawqhj 310 2 , , , cord-023584-yaxawqhj 310 3 the the DT cord-023584-yaxawqhj 310 4 products product NNS cord-023584-yaxawqhj 310 5 of of IN cord-023584-yaxawqhj 310 6 this this DT cord-023584-yaxawqhj 310 7 effort effort NN cord-023584-yaxawqhj 310 8 will will MD cord-023584-yaxawqhj 310 9 find find VB cord-023584-yaxawqhj 310 10 application application NN cord-023584-yaxawqhj 310 11 only only RB cord-023584-yaxawqhj 310 12 in in IN cord-023584-yaxawqhj 310 13 a a DT cord-023584-yaxawqhj 310 14 relatively relatively RB cord-023584-yaxawqhj 310 15 small small JJ cord-023584-yaxawqhj 310 16 number number NN cord-023584-yaxawqhj 310 17 of of IN cord-023584-yaxawqhj 310 18 virus virus NN cord-023584-yaxawqhj 310 19 diseases disease NNS cord-023584-yaxawqhj 310 20 for for IN cord-023584-yaxawqhj 310 21 the the DT cord-023584-yaxawqhj 310 22 reasons reason NNS cord-023584-yaxawqhj 310 23 outlined outline VBN cord-023584-yaxawqhj 310 24 above above RB cord-023584-yaxawqhj 310 25 . . . cord-023584-yaxawqhj 311 1 Only only RB cord-023584-yaxawqhj 311 2 for for IN cord-023584-yaxawqhj 311 3 those those DT cord-023584-yaxawqhj 311 4 diseases disease NNS cord-023584-yaxawqhj 311 5 of of IN cord-023584-yaxawqhj 311 6 high high JJ cord-023584-yaxawqhj 311 7 economic economic JJ cord-023584-yaxawqhj 311 8 importance importance NN cord-023584-yaxawqhj 311 9 , , , cord-023584-yaxawqhj 311 10 and and CC cord-023584-yaxawqhj 311 11 for for IN cord-023584-yaxawqhj 311 12 which which WDT cord-023584-yaxawqhj 311 13 no no DT cord-023584-yaxawqhj 311 14 effective effective JJ cord-023584-yaxawqhj 311 15 vaccines vaccine NNS cord-023584-yaxawqhj 311 16 are be VBP cord-023584-yaxawqhj 311 17 available available JJ cord-023584-yaxawqhj 311 18 , , , cord-023584-yaxawqhj 311 19 will will MD cord-023584-yaxawqhj 311 20 specific specific VB cord-023584-yaxawqhj 311 21 antiviral antiviral JJ cord-023584-yaxawqhj 311 22 drugs drug NNS cord-023584-yaxawqhj 311 23 ever ever RB cord-023584-yaxawqhj 311 24 be be VB cord-023584-yaxawqhj 311 25 a a DT cord-023584-yaxawqhj 311 26 commercial commercial JJ cord-023584-yaxawqhj 311 27 reality reality NN cord-023584-yaxawqhj 311 28 . . . cord-023584-yaxawqhj 312 1 The the DT cord-023584-yaxawqhj 312 2 present present JJ cord-023584-yaxawqhj 312 3 paucity paucity NN cord-023584-yaxawqhj 312 4 of of IN cord-023584-yaxawqhj 312 5 such such JJ cord-023584-yaxawqhj 312 6 drugs drug NNS cord-023584-yaxawqhj 312 7 is be VBZ cord-023584-yaxawqhj 312 8 undoubtedly undoubtedly RB cord-023584-yaxawqhj 312 9 due due JJ cord-023584-yaxawqhj 312 10 largely largely RB cord-023584-yaxawqhj 312 11 to to IN cord-023584-yaxawqhj 312 12 the the DT cord-023584-yaxawqhj 312 13 intimate intimate JJ cord-023584-yaxawqhj 312 14 association association NN cord-023584-yaxawqhj 312 15 of of IN cord-023584-yaxawqhj 312 16 viruses virus NNS cord-023584-yaxawqhj 312 17 at at IN cord-023584-yaxawqhj 312 18 the the DT cord-023584-yaxawqhj 312 19 molecular molecular JJ cord-023584-yaxawqhj 312 20 level level NN cord-023584-yaxawqhj 312 21 with with IN cord-023584-yaxawqhj 312 22 their -PRON- PRP$ cord-023584-yaxawqhj 312 23 host host NN cord-023584-yaxawqhj 312 24 cells cell NNS cord-023584-yaxawqhj 312 25 . . . cord-023584-yaxawqhj 313 1 For for IN cord-023584-yaxawqhj 313 2 this this DT cord-023584-yaxawqhj 313 3 reason reason NN cord-023584-yaxawqhj 313 4 , , , cord-023584-yaxawqhj 313 5 disease disease NN cord-023584-yaxawqhj 313 6 targets target NNS cord-023584-yaxawqhj 313 7 must must MD cord-023584-yaxawqhj 313 8 be be VB cord-023584-yaxawqhj 313 9 carefully carefully RB cord-023584-yaxawqhj 313 10 defined define VBN cord-023584-yaxawqhj 313 11 , , , cord-023584-yaxawqhj 313 12 screening screening NN cord-023584-yaxawqhj 313 13 procedures procedure NNS cord-023584-yaxawqhj 313 14 made make VBN cord-023584-yaxawqhj 313 15 as as RB cord-023584-yaxawqhj 313 16 meaningful meaningful JJ cord-023584-yaxawqhj 313 17 as as IN cord-023584-yaxawqhj 313 18 possible possible JJ cord-023584-yaxawqhj 313 19 , , , cord-023584-yaxawqhj 313 20 and and CC cord-023584-yaxawqhj 313 21 the the DT cord-023584-yaxawqhj 313 22 limitations limitation NNS cord-023584-yaxawqhj 313 23 of of IN cord-023584-yaxawqhj 313 24 animal animal NN cord-023584-yaxawqhj 313 25 models model NNS cord-023584-yaxawqhj 313 26 be be VB cord-023584-yaxawqhj 313 27 clearly clearly RB cord-023584-yaxawqhj 313 28 recognized recognize VBN cord-023584-yaxawqhj 313 29 . . . cord-023584-yaxawqhj 314 1 Only only RB cord-023584-yaxawqhj 314 2 by by IN cord-023584-yaxawqhj 314 3 attention attention NN cord-023584-yaxawqhj 314 4 to to IN cord-023584-yaxawqhj 314 5 these these DT cord-023584-yaxawqhj 314 6 details detail NNS cord-023584-yaxawqhj 314 7 can can MD cord-023584-yaxawqhj 314 8 the the DT cord-023584-yaxawqhj 314 9 maximum maximum JJ cord-023584-yaxawqhj 314 10 effort effort NN cord-023584-yaxawqhj 314 11 be be VB cord-023584-yaxawqhj 314 12 brought bring VBN cord-023584-yaxawqhj 314 13 to to IN cord-023584-yaxawqhj 314 14 this this DT cord-023584-yaxawqhj 314 15 difficult difficult JJ cord-023584-yaxawqhj 314 16 problem problem NN cord-023584-yaxawqhj 314 17 . . . cord-023584-yaxawqhj 315 1 Again again RB cord-023584-yaxawqhj 315 2 , , , cord-023584-yaxawqhj 315 3 the the DT cord-023584-yaxawqhj 315 4 lack lack NN cord-023584-yaxawqhj 315 5 of of IN cord-023584-yaxawqhj 315 6 clinically clinically RB cord-023584-yaxawqhj 315 7 useful useful JJ cord-023584-yaxawqhj 315 8 drugs drug NNS cord-023584-yaxawqhj 315 9 allows allow VBZ cord-023584-yaxawqhj 315 10 no no DT cord-023584-yaxawqhj 315 11 more more JJR cord-023584-yaxawqhj 315 12 than than IN cord-023584-yaxawqhj 315 13 speculation speculation NN cord-023584-yaxawqhj 315 14 on on IN cord-023584-yaxawqhj 315 15 the the DT cord-023584-yaxawqhj 315 16 possibilities possibility NNS cord-023584-yaxawqhj 315 17 of of IN cord-023584-yaxawqhj 315 18 drug drug NN cord-023584-yaxawqhj 315 19 - - HYPH cord-023584-yaxawqhj 315 20 resistant resistant JJ cord-023584-yaxawqhj 315 21 viruses virus NNS cord-023584-yaxawqhj 315 22 emerging emerge VBG cord-023584-yaxawqhj 315 23 when when WRB cord-023584-yaxawqhj 315 24 antiviral antiviral JJ cord-023584-yaxawqhj 315 25 drugs drug NNS cord-023584-yaxawqhj 315 26 are be VBP cord-023584-yaxawqhj 315 27 eventually eventually RB cord-023584-yaxawqhj 315 28 in in IN cord-023584-yaxawqhj 315 29 widespread widespread JJ cord-023584-yaxawqhj 315 30 use use NN cord-023584-yaxawqhj 315 31 . . . cord-023584-yaxawqhj 316 1 The the DT cord-023584-yaxawqhj 316 2 phenomenon phenomenon NN cord-023584-yaxawqhj 316 3 of of IN cord-023584-yaxawqhj 316 4 drug drug NN cord-023584-yaxawqhj 316 5 resistance resistance NN cord-023584-yaxawqhj 316 6 in in IN cord-023584-yaxawqhj 316 7 viruses virus NNS cord-023584-yaxawqhj 316 8 is be VBZ cord-023584-yaxawqhj 316 9 well well RB cord-023584-yaxawqhj 316 10 established establish VBN cord-023584-yaxawqhj 316 11 in in IN cord-023584-yaxawqhj 316 12 the the DT cord-023584-yaxawqhj 316 13 laboratory laboratory NN cord-023584-yaxawqhj 316 14 ( ( -LRB- cord-023584-yaxawqhj 316 15 Melnick Melnick NNP cord-023584-yaxawqhj 316 16 et et NNP cord-023584-yaxawqhj 316 17 al al NNP cord-023584-yaxawqhj 316 18 . . NNP cord-023584-yaxawqhj 316 19 , , , cord-023584-yaxawqhj 316 20 1961 1961 CD cord-023584-yaxawqhj 316 21 ; ; . cord-023584-yaxawqhj 317 1 Tamm Tamm NNP cord-023584-yaxawqhj 317 2 and and CC cord-023584-yaxawqhj 317 3 Eggers Eggers NNP cord-023584-yaxawqhj 317 4 , , , cord-023584-yaxawqhj 317 5 1962 1962 CD cord-023584-yaxawqhj 317 6 ; ; : cord-023584-yaxawqhj 317 7 Renis Renis NNP cord-023584-yaxawqhj 317 8 and and CC cord-023584-yaxawqhj 317 9 Buthala Buthala NNP cord-023584-yaxawqhj 317 10 , , , cord-023584-yaxawqhj 317 11 1965 1965 CD cord-023584-yaxawqhj 317 12 ) ) -RRB- cord-023584-yaxawqhj 317 13 , , , cord-023584-yaxawqhj 317 14 and and CC cord-023584-yaxawqhj 317 15 , , , cord-023584-yaxawqhj 317 16 unless unless IN cord-023584-yaxawqhj 317 17 potential potential JJ cord-023584-yaxawqhj 317 18 antiviral antiviral JJ cord-023584-yaxawqhj 317 19 drugs drug NNS cord-023584-yaxawqhj 317 20 are be VBP cord-023584-yaxawqhj 317 21 free free JJ cord-023584-yaxawqhj 317 22 of of IN cord-023584-yaxawqhj 317 23 this this DT cord-023584-yaxawqhj 317 24 serious serious JJ cord-023584-yaxawqhj 317 25 defect defect NN cord-023584-yaxawqhj 317 26 , , , cord-023584-yaxawqhj 317 27 their -PRON- PRP$ cord-023584-yaxawqhj 317 28 commercial commercial JJ cord-023584-yaxawqhj 317 29 life life NN cord-023584-yaxawqhj 317 30 will will MD cord-023584-yaxawqhj 317 31 be be VB cord-023584-yaxawqhj 317 32 embarrassingly embarrassingly RB cord-023584-yaxawqhj 317 33 short short JJ cord-023584-yaxawqhj 317 34 . . . cord-023584-yaxawqhj 318 1 The the DT cord-023584-yaxawqhj 318 2 treatment treatment NN cord-023584-yaxawqhj 318 3 of of IN cord-023584-yaxawqhj 318 4 the the DT cord-023584-yaxawqhj 318 5 symptoms symptom NNS cord-023584-yaxawqhj 318 6 , , , cord-023584-yaxawqhj 318 7 rather rather RB cord-023584-yaxawqhj 318 8 than than IN cord-023584-yaxawqhj 318 9 the the DT cord-023584-yaxawqhj 318 10 cause cause NN cord-023584-yaxawqhj 318 11 of of IN cord-023584-yaxawqhj 318 12 a a DT cord-023584-yaxawqhj 318 13 disease disease NN cord-023584-yaxawqhj 318 14 , , , cord-023584-yaxawqhj 318 15 has have VBZ cord-023584-yaxawqhj 318 16 been be VBN cord-023584-yaxawqhj 318 17 the the DT cord-023584-yaxawqhj 318 18 mainstay mainstay NN cord-023584-yaxawqhj 318 19 of of IN cord-023584-yaxawqhj 318 20 medical medical JJ cord-023584-yaxawqhj 318 21 practice practice NN cord-023584-yaxawqhj 318 22 from from IN cord-023584-yaxawqhj 318 23 time time NN cord-023584-yaxawqhj 318 24 immemorial immemorial JJ cord-023584-yaxawqhj 318 25 , , , cord-023584-yaxawqhj 318 26 and and CC cord-023584-yaxawqhj 318 27 this this DT cord-023584-yaxawqhj 318 28 is be VBZ cord-023584-yaxawqhj 318 29 still still RB cord-023584-yaxawqhj 318 30 the the DT cord-023584-yaxawqhj 318 31 case case NN cord-023584-yaxawqhj 318 32 with with IN cord-023584-yaxawqhj 318 33 most most JJS cord-023584-yaxawqhj 318 34 virus virus NN cord-023584-yaxawqhj 318 35 disease disease NN cord-023584-yaxawqhj 318 36 . . . cord-023584-yaxawqhj 319 1 The the DT cord-023584-yaxawqhj 319 2 short short JJ cord-023584-yaxawqhj 319 3 incubation incubation NN cord-023584-yaxawqhj 319 4 period period NN cord-023584-yaxawqhj 319 5 of of IN cord-023584-yaxawqhj 319 6 many many JJ cord-023584-yaxawqhj 319 7 virus virus NN cord-023584-yaxawqhj 319 8 diseases disease NNS cord-023584-yaxawqhj 319 9 will will MD cord-023584-yaxawqhj 319 10 inevitably inevitably RB cord-023584-yaxawqhj 319 11 restrict restrict VB cord-023584-yaxawqhj 319 12 the the DT cord-023584-yaxawqhj 319 13 therapeutic therapeutic JJ cord-023584-yaxawqhj 319 14 use use NN cord-023584-yaxawqhj 319 15 of of IN cord-023584-yaxawqhj 319 16 antiviral antiviral JJ cord-023584-yaxawqhj 319 17 drugs drug NNS cord-023584-yaxawqhj 319 18 , , , cord-023584-yaxawqhj 319 19 and and CC cord-023584-yaxawqhj 319 20 in in IN cord-023584-yaxawqhj 319 21 cases case NNS cord-023584-yaxawqhj 319 22 where where WRB cord-023584-yaxawqhj 319 23 symptoms symptom NNS cord-023584-yaxawqhj 319 24 have have VBP cord-023584-yaxawqhj 319 25 already already RB cord-023584-yaxawqhj 319 26 appeared appear VBN cord-023584-yaxawqhj 319 27 , , , cord-023584-yaxawqhj 319 28 the the DT cord-023584-yaxawqhj 319 29 physician physician NN cord-023584-yaxawqhj 319 30 and and CC cord-023584-yaxawqhj 319 31 layman layman NN cord-023584-yaxawqhj 319 32 alike alike RB cord-023584-yaxawqhj 319 33 will will MD cord-023584-yaxawqhj 319 34 have have VB cord-023584-yaxawqhj 319 35 recourse recourse NN cord-023584-yaxawqhj 319 36 to to IN cord-023584-yaxawqhj 319 37 the the DT cord-023584-yaxawqhj 319 38 extensive extensive JJ cord-023584-yaxawqhj 319 39 armamentanurn armamentanurn NN cord-023584-yaxawqhj 319 40 of of IN cord-023584-yaxawqhj 319 41 palliatives palliative NNS cord-023584-yaxawqhj 319 42 available available JJ cord-023584-yaxawqhj 319 43 for for IN cord-023584-yaxawqhj 319 44 alleviating alleviate VBG cord-023584-yaxawqhj 319 45 the the DT cord-023584-yaxawqhj 319 46 symptoms symptom NNS cord-023584-yaxawqhj 319 47 of of IN cord-023584-yaxawqhj 319 48 virus virus NN cord-023584-yaxawqhj 319 49 disease disease NN cord-023584-yaxawqhj 319 50 . . . cord-023584-yaxawqhj 320 1 All all PDT cord-023584-yaxawqhj 320 2 the the DT cord-023584-yaxawqhj 320 3 same same JJ cord-023584-yaxawqhj 320 4 , , , cord-023584-yaxawqhj 320 5 this this DT cord-023584-yaxawqhj 320 6 is be VBZ cord-023584-yaxawqhj 320 7 clearly clearly RB cord-023584-yaxawqhj 320 8 an an DT cord-023584-yaxawqhj 320 9 unsatisfactory unsatisfactory JJ cord-023584-yaxawqhj 320 10 state state NN cord-023584-yaxawqhj 320 11 of of IN cord-023584-yaxawqhj 320 12 affairs affair NNS cord-023584-yaxawqhj 320 13 , , , cord-023584-yaxawqhj 320 14 and and CC cord-023584-yaxawqhj 320 15 the the DT cord-023584-yaxawqhj 320 16 ultimate ultimate JJ cord-023584-yaxawqhj 320 17 goal goal NN cord-023584-yaxawqhj 320 18 of of IN cord-023584-yaxawqhj 320 19 antiviral antiviral JJ cord-023584-yaxawqhj 320 20 research research NN cord-023584-yaxawqhj 320 21 is be VBZ cord-023584-yaxawqhj 320 22 the the DT cord-023584-yaxawqhj 320 23 prevention prevention NN cord-023584-yaxawqhj 320 24 of of IN cord-023584-yaxawqhj 320 25 virus virus NN cord-023584-yaxawqhj 320 26 disease disease NN cord-023584-yaxawqhj 320 27 . . . cord-023584-yaxawqhj 321 1 As as IN cord-023584-yaxawqhj 321 2 the the DT cord-023584-yaxawqhj 321 3 understanding understanding NN cord-023584-yaxawqhj 321 4 of of IN cord-023584-yaxawqhj 321 5 viruses virus NNS cord-023584-yaxawqhj 321 6 increases increase NNS cord-023584-yaxawqhj 321 7 , , , cord-023584-yaxawqhj 321 8 so so IN cord-023584-yaxawqhj 321 9 a a DT cord-023584-yaxawqhj 321 10 more more RBR cord-023584-yaxawqhj 321 11 rational rational JJ cord-023584-yaxawqhj 321 12 approach approach NN cord-023584-yaxawqhj 321 13 to to IN cord-023584-yaxawqhj 321 14 the the DT cord-023584-yaxawqhj 321 15 chemotherapy chemotherapy NN cord-023584-yaxawqhj 321 16 of of IN cord-023584-yaxawqhj 321 17 virus virus NN cord-023584-yaxawqhj 321 18 diseases disease NNS cord-023584-yaxawqhj 321 19 will will MD cord-023584-yaxawqhj 321 20 become become VB cord-023584-yaxawqhj 321 21 feasible feasible JJ cord-023584-yaxawqhj 321 22 . . . cord-023584-yaxawqhj 322 1 Also also RB cord-023584-yaxawqhj 322 2 , , , cord-023584-yaxawqhj 322 3 random random JJ cord-023584-yaxawqhj 322 4 discoveries discovery NNS cord-023584-yaxawqhj 322 5 of of IN cord-023584-yaxawqhj 322 6 antiviral antiviral JJ cord-023584-yaxawqhj 322 7 activity activity NN cord-023584-yaxawqhj 322 8 in in IN cord-023584-yaxawqhj 322 9 novel novel JJ cord-023584-yaxawqhj 322 10 chemical chemical NN cord-023584-yaxawqhj 322 11 compounds compound NNS cord-023584-yaxawqhj 322 12 will will MD cord-023584-yaxawqhj 322 13 shed shed VB cord-023584-yaxawqhj 322 14 further further JJ cord-023584-yaxawqhj 322 15 light light NN cord-023584-yaxawqhj 322 16 on on IN cord-023584-yaxawqhj 322 17 those those DT cord-023584-yaxawqhj 322 18 areas area NNS cord-023584-yaxawqhj 322 19 of of IN cord-023584-yaxawqhj 322 20 virus virus NN cord-023584-yaxawqhj 322 21 metabolism metabolism NN cord-023584-yaxawqhj 322 22 that that WDT cord-023584-yaxawqhj 322 23 are be VBP cord-023584-yaxawqhj 322 24 susceptible susceptible JJ cord-023584-yaxawqhj 322 25 to to IN cord-023584-yaxawqhj 322 26 chemical chemical JJ cord-023584-yaxawqhj 322 27 attack attack NN cord-023584-yaxawqhj 322 28 . . . cord-023584-yaxawqhj 323 1 With with IN cord-023584-yaxawqhj 323 2 increasing increase VBG cord-023584-yaxawqhj 323 3 con con NN cord-023584-yaxawqhj 323 4 - - HYPH cord-023584-yaxawqhj 323 5 tributions tribution NNS cord-023584-yaxawqhj 323 6 from from IN cord-023584-yaxawqhj 323 7 both both PDT cord-023584-yaxawqhj 323 8 these these DT cord-023584-yaxawqhj 323 9 approaches approach NNS cord-023584-yaxawqhj 323 10 , , , cord-023584-yaxawqhj 323 11 virus virus NN cord-023584-yaxawqhj 323 12 chemotherapy chemotherapy NN cord-023584-yaxawqhj 323 13 should should MD cord-023584-yaxawqhj 323 14 soon soon RB cord-023584-yaxawqhj 323 15 emerge emerge VB cord-023584-yaxawqhj 323 16 from from IN cord-023584-yaxawqhj 323 17 a a DT cord-023584-yaxawqhj 323 18 theoretical theoretical JJ cord-023584-yaxawqhj 323 19 possibility possibility NN cord-023584-yaxawqhj 323 20 to to IN cord-023584-yaxawqhj 323 21 a a DT cord-023584-yaxawqhj 323 22 practical practical JJ cord-023584-yaxawqhj 323 23 reality reality NN cord-023584-yaxawqhj 323 24 , , , cord-023584-yaxawqhj 323 25 and and CC cord-023584-yaxawqhj 323 26 antiviral antiviral JJ cord-023584-yaxawqhj 323 27 drugs drug NNS cord-023584-yaxawqhj 323 28 ivill ivill NNS cord-023584-yaxawqhj 323 29 make make VBP cord-023584-yaxawqhj 323 30 their -PRON- PRP$ cord-023584-yaxawqhj 323 31 long long JJ cord-023584-yaxawqhj 323 32 awaited await VBN cord-023584-yaxawqhj 323 33 contributions contribution NNS cord-023584-yaxawqhj 323 34 to to IN cord-023584-yaxawqhj 323 35 clinical clinical JJ cord-023584-yaxawqhj 323 36 medicine medicine NN cord-023584-yaxawqhj 323 37 . . . cord-023584-yaxawqhj 324 1 Modern modern JJ cord-023584-yaxawqhj 324 2 Trends Trends NNPS cord-023584-yaxawqhj 324 3 in in IN cord-023584-yaxawqhj 324 4 Medical Medical NNP cord-023584-yaxawqhj 324 5 Virology Virology NNP cord-023584-yaxawqhj 324 6 Zn Zn NNP cord-023584-yaxawqhj 324 7 " " '' cord-023584-yaxawqhj 324 8 Virus virus NN cord-023584-yaxawqhj 324 9 - - HYPH cord-023584-yaxawqhj 324 10 Induced induce VBN cord-023584-yaxawqhj 324 11 Immunopathology Immunopathology NNP cord-023584-yaxawqhj 324 12 Arch Arch NNP cord-023584-yaxawqhj 324 13 . . . cord-023584-yaxawqhj 325 1 GesanLfe GesanLfe NNP cord-023584-yaxawqhj 325 2 Virusforsch Virusforsch NNP cord-023584-yaxawqhj 325 3 . . . cord-023584-yaxawqhj 326 1 30 30 CD cord-023584-yaxawqhj 326 2 Zn Zn NNP cord-023584-yaxawqhj 326 3 " " `` cord-023584-yaxawqhj 326 4 Diagnostic Diagnostic NNP cord-023584-yaxawqhj 326 5 Procedures procedure NNS cord-023584-yaxawqhj 326 6 for for IN cord-023584-yaxawqhj 326 7 Virus Virus NNP cord-023584-yaxawqhj 326 8 and and CC cord-023584-yaxawqhj 326 9 Rickettsia1 Rickettsia1 NNP cord-023584-yaxawqhj 326 10 Infections infection NNS cord-023584-yaxawqhj 327 1 Amer Amer NNP cord-023584-yaxawqhj 327 2 Zn Zn NNP cord-023584-yaxawqhj 328 1 " " `` cord-023584-yaxawqhj 328 2 Topics topic NNS cord-023584-yaxawqhj 328 3 in in IN cord-023584-yaxawqhj 328 4 Medicinal Medicinal NNP cord-023584-yaxawqhj 328 5 Chemistry Chemistry NNP cord-023584-yaxawqhj 328 6 Ezperientia Ezperientia NNP cord-023584-yaxawqhj 328 7 16 16 CD cord-023584-yaxawqhj 328 8 , , , cord-023584-yaxawqhj 328 9 487 487 CD cord-023584-yaxawqhj 328 10 Virology Virology NNP cord-023584-yaxawqhj 328 11 4 4 CD cord-023584-yaxawqhj 328 12 , , , cord-023584-yaxawqhj 328 13 483 483 CD cord-023584-yaxawqhj 328 14 . . . cord-023584-yaxawqhj 329 1 Tamm Tamm NNP cord-023584-yaxawqhj 329 2 , , , cord-023584-yaxawqhj 329 3 J. J. NNP cord-023584-yaxawqhj 329 4 , , , cord-023584-yaxawqhj 329 5 and and CC cord-023584-yaxawqhj 329 6 Overman Overman NNP cord-023584-yaxawqhj 329 7 Antiviral Antiviral NNP cord-023584-yaxawqhj 329 8 Substances Substances NNPS